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<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPL5</accession>
    <name>A3FPL5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">High affinity sulfate transporter-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_90</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
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        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
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    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388361.1">
        <property type="nucleotide sequence ID" value="XM_001388324.1"/>
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    <dbReference type="AlphaFoldDB" id="A3FPL5"/>
    <dbReference type="STRING" id="353152.A3FPL5"/>
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    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_90"/>
    <dbReference type="InParanoid" id="A3FPL5"/>
    <dbReference type="OMA" id="FDAYHRY"/>
    <dbReference type="OrthoDB" id="288203at2759"/>
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        <property type="component" value="Chromosome 7"/>
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    <dbReference type="GO" id="GO:0016020">
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    <dbReference type="CDD" id="cd07042">
        <property type="entry name" value="STAS_SulP_like_sulfate_transporter"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="SLC26A/SulP_dom"/>
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    <dbReference type="PANTHER" id="PTHR11814">
        <property type="entry name" value="SULFATE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01740">
        <property type="entry name" value="STAS"/>
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    <dbReference type="Pfam" id="PF00916">
        <property type="entry name" value="Sulfate_transp"/>
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        <property type="entry name" value="SpoIIaa-like"/>
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        <property type="entry name" value="STAS"/>
        <property type="match status" value="1"/>
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    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="176"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="255"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="580"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="627"/>
            <end position="644"/>
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    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="682"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="domain" description="STAS" evidence="7">
        <location>
            <begin position="736"/>
            <end position="900"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="912" mass="102600" checksum="3E7D8D6FE7923064" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPM5</accession>
    <name>A3FPM5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RNA exonuclease 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd7_1030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the REXO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388371.1">
        <property type="nucleotide sequence ID" value="XM_001388334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPM5"/>
    <dbReference type="STRING" id="353152.A3FPM5"/>
    <dbReference type="GeneID" id="3371870"/>
    <dbReference type="KEGG" id="cpv:cgd7_1030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1030"/>
    <dbReference type="InParanoid" id="A3FPM5"/>
    <dbReference type="OMA" id="NWPCALP"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008408">
        <property type="term" value="F:3'-5' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06144">
        <property type="entry name" value="REX4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037431">
        <property type="entry name" value="REX4_DEDDh_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047021">
        <property type="entry name" value="REXO1/3/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801:SF45">
        <property type="entry name" value="RNA EXONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12801">
        <property type="entry name" value="RNA EXONUCLEASE REXO1 / RECO3 FAMILY MEMBER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exonuclease" evidence="11">
        <location>
            <begin position="8"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="226"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="227"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016937"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="250" mass="28791" checksum="E0854645B0A76A36" modified="2007-04-03" version="1">MSKKTLPRAISIDCEMVGCGENGHISVLGRIAVVDDKLKLLMDAFVKPSMRVTNFRTKWSGLTWDKLKYGESFESIQKKFLQIVEHYRKESTSGLVFVGHDISNDFQVLKWTPPESEIRDTCTYFPLRKLLIKSLLEKGEITHHQKEGFLRQKPSLRSLSKHVLNLNIQQGSHCPWEDAKSTMMLYLMVRDRWEALVYNRNSITNSPTTIALNNEQNEDLGEAVIPHNKKKKNKKKKDIKKGKHVTINGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPT8</accession>
    <name>A3FPT8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388317.1">
        <property type="nucleotide sequence ID" value="XM_001388280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPT8"/>
    <dbReference type="GeneID" id="3375942"/>
    <dbReference type="KEGG" id="cpv:cgd6_1890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1890"/>
    <dbReference type="InParanoid" id="A3FPT8"/>
    <dbReference type="OrthoDB" id="343075at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013885">
        <property type="entry name" value="DUF1764_euk"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08576">
        <property type="entry name" value="DUF1764"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="102" mass="11626" checksum="FE4241E5A9DDF05E" modified="2007-04-03" version="1">MDSKGKKNLRSSNGDRKKNAVARATGEMNKIFETILNKKATLKANSRAQKEKNKLAKRTKKDSVIRDNTNKSLDINYGYIKPIRYLNDGLPVYRLEDINLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPU3</accession>
    <name>A3FPU3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U1 snrnp, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_2150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388322.1">
        <property type="nucleotide sequence ID" value="XM_001388285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPU3"/>
    <dbReference type="FunCoup" id="A3FPU3">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPU3"/>
    <dbReference type="GeneID" id="3375948"/>
    <dbReference type="KEGG" id="cpv:cgd6_2150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2150"/>
    <dbReference type="InParanoid" id="A3FPU3"/>
    <dbReference type="OMA" id="KWDASAF"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="26"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="267" mass="30750" checksum="3DCA3D28428CF5B6" modified="2007-04-03" version="1">MNNSLMDRKNGIKVLKNSLSDDDENKTIYINNLNDSISIPKQKLSLEEIFAKYGKIESIKMFNSYFRKGQAWITFSNAVSAVNAVNNEIGTQIFGKHVNVSFAAKESERRNIQVRNSSSNIRMVPKSINARIELYKQYLAQWLKNAENNGLFQTLDDPEKNQIKLVNNQVLYDNNYVNLMRSNKNKKLNVHPFINNELTQNSLGRPEMQIDGTTSFLHRLPNNASPLEVSNTVFVQMEMGICREEELYTLFSHINGFKELRFIPVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPV5</accession>
    <name>A3FPV5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Polyadenylate-binding protein</fullName>
            <shortName evidence="10">PABP</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd6_3010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Binds the poly(A) tail of mRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the polyadenylate-binding protein type-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388334.1">
        <property type="nucleotide sequence ID" value="XM_001388297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPV5"/>
    <dbReference type="FunCoup" id="A3FPV5">
        <property type="interactions" value="210"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPV5"/>
    <dbReference type="GeneID" id="3375959"/>
    <dbReference type="KEGG" id="cpv:cgd6_3010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3010"/>
    <dbReference type="InParanoid" id="A3FPV5"/>
    <dbReference type="OMA" id="QQPGFMP"/>
    <dbReference type="OrthoDB" id="19742at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12378">
        <property type="entry name" value="RRM1_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12379">
        <property type="entry name" value="RRM2_I_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000651">
        <property type="entry name" value="Poly(A) binding protein cytoplasmic 1 like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000003">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000648">
        <property type="entry name" value="Polyadenylate-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1900.10">
        <property type="entry name" value="c-terminal domain of poly(a) binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036053">
        <property type="entry name" value="PABP-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006515">
        <property type="entry name" value="PABP_1234"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002004">
        <property type="entry name" value="PABP_HYD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034364">
        <property type="entry name" value="PABP_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045305">
        <property type="entry name" value="RRM2_I_PABPs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01628">
        <property type="entry name" value="PABP-1234"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00658">
        <property type="entry name" value="MLLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00517">
        <property type="entry name" value="PolyA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63570">
        <property type="entry name" value="PABC (PABP) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51309">
        <property type="entry name" value="PABC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 9 10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="12"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="100"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="190"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="12">
        <location>
            <begin position="363"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="domain" description="PABC" evidence="13">
        <location>
            <begin position="665"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="264"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="576"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="285"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="576"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAZ51528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="746" mass="81074" checksum="7E02E0FEF1B13C71" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ07</accession>
    <name>A3FQ07_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_4900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388448.1">
        <property type="nucleotide sequence ID" value="XM_001388411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ07"/>
    <dbReference type="FunCoup" id="A3FQ07">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ07"/>
    <dbReference type="GeneID" id="3374362"/>
    <dbReference type="KEGG" id="cpv:cgd8_4900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4900"/>
    <dbReference type="InParanoid" id="A3FQ07"/>
    <dbReference type="OMA" id="GHVVETN"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000010">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="1"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="158" mass="18750" checksum="94391B7FDFA54CD9" modified="2007-04-03" version="1">MLKFLLLVNKQGQIRLSQYYTHVSKEERFILEGQLIRKCLLKGENQCPFIEFNNYKIVFRRYASLYFIMGLENSNTNELSYYELIHFIVETLDKYFENVCELDIMFNLDKAHIIIEEIIMCGRIAETNKSNIMQYMSLLEKASQSNDDINSMIMSVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ36</accession>
    <name>A3FQ36_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative topoisomerase VIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_2720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388116.1">
        <property type="nucleotide sequence ID" value="XM_001388079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ36"/>
    <dbReference type="STRING" id="353152.A3FQ36"/>
    <dbReference type="GeneID" id="3374071"/>
    <dbReference type="KEGG" id="cpv:cgd3_2720"/>
    <dbReference type="InParanoid" id="A3FQ36"/>
    <dbReference type="OMA" id="ICKSGIT"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013048">
        <property type="entry name" value="Meiotic_Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01551">
        <property type="entry name" value="SPO11HOMOLOG"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="3">
        <location>
            <begin position="63"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="235" mass="26797" checksum="F0D83F7F7B28D970" modified="2007-04-03" version="1" fragment="single">DFSEILQIPRISFGLFPSPKGMIGGRIKLIYKDVEELGVSGATITDIFDPNDSKYIIKTNVKYLLVIEKASIFQYLMEREIYNRIPCLVITGKGFPDISTRKLVSDIICKSGITALYLGDFDPHGINIYLTYVRGSSNFESQLAACPSIYYLGIHFEDTELIPSDTRVILSEKDRSTLKSLIEDPAIKVSTNIKYKCKLMYEHNYKCELEAFQSISSDYLVNTYLPSKILRRTWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ75</accession>
    <name>A3FQ75_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_1880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388211.1">
        <property type="nucleotide sequence ID" value="XM_001388174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ75"/>
    <dbReference type="STRING" id="353152.A3FQ75"/>
    <dbReference type="GeneID" id="3373444"/>
    <dbReference type="KEGG" id="cpv:cgd2_1880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1880"/>
    <dbReference type="InParanoid" id="A3FQ75"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="115" mass="12890" checksum="F874FFB568E364A8" modified="2007-04-03" version="1" fragment="single">MEAVKGERGIVQIKGCFYSLTPGGIIMQNIVMPLMTKSLGVFIRENRALRKQNSSHRISPELVKNLSFQIVNGLAALHSSGYTHRDFKPDNILLMDTDDSERKFPTINICDLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ98</accession>
    <name>A3FQ98_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Dynamin-related protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_3400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001388197.1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ98"/>
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    <dbReference type="OrthoDB" id="5061070at2759"/>
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        <property type="component" value="Chromosome 2"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="2"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
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    </dbReference>
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        <property type="entry name" value="Dynamin"/>
    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Dynamin_N"/>
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    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF21">
        <property type="entry name" value="DYNAMIN RELATED PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="4">
        <location>
            <begin position="32"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="3">
        <location>
            <begin position="692"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="784" mass="88390" checksum="89E46641110E125B" modified="2007-04-03" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQD2</accession>
    <name>A3FQD2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA repair and meiosis protein Mre11 (Emb/CAB50793.1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_1420</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388154.1">
        <property type="nucleotide sequence ID" value="XM_001388117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQD2"/>
    <dbReference type="STRING" id="353152.A3FQD2"/>
    <dbReference type="GeneID" id="3371488"/>
    <dbReference type="KEGG" id="cpv:cgd1_1420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1420"/>
    <dbReference type="InParanoid" id="A3FQD2"/>
    <dbReference type="OMA" id="ECIDREN"/>
    <dbReference type="OrthoDB" id="30417at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006303">
        <property type="term" value="P:double-strand break repair via nonhomologous end joining"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097552">
        <property type="term" value="P:mitochondrial double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007095">
        <property type="term" value="P:mitotic G2 DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00840">
        <property type="entry name" value="MPP_Mre11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.110">
        <property type="entry name" value="Mre11, capping domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038487">
        <property type="entry name" value="Mre11_capping_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007281">
        <property type="entry name" value="Mre11_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041796">
        <property type="entry name" value="Mre11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10139:SF1">
        <property type="entry name" value="DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04152">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01347">
        <property type="entry name" value="Mre11_DNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mre11 DNA-binding" evidence="3">
        <location>
            <begin position="226"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="467"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="476"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="513" mass="58800" checksum="CAFD93DA84416144" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQQ4</accession>
    <name>A3FQQ4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Coatomer epsilon subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd4_4100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COPE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAZ51216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388083.1">
        <property type="nucleotide sequence ID" value="XM_001388046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQQ4"/>
    <dbReference type="FunCoup" id="A3FQQ4">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQQ4"/>
    <dbReference type="GeneID" id="3372413"/>
    <dbReference type="KEGG" id="cpv:cgd4_4100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4100"/>
    <dbReference type="InParanoid" id="A3FQQ4"/>
    <dbReference type="OMA" id="YIYQIYM"/>
    <dbReference type="OrthoDB" id="310217at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006822">
        <property type="entry name" value="Coatomer_esu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10805:SF0">
        <property type="entry name" value="COATOMER SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04733">
        <property type="entry name" value="Coatomer_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="312" mass="36286" checksum="240F451255B4F87C" modified="2007-04-03" version="1">MNSGYYEKVLMLIKEAEHIRSQDFDVDVLLELIQFRCKIHLNQIEKDSIGSYYSESISNQKFGIAAVCLFTIFNLPETTDERRYELINEMMQLYVHNNNKIVMIDVILLLMNLYMNDFKSALSITECAPPSLKIIQVFVFCIMNRYDLAQSLFDDLIENYDTYTCELENYHSLSNFKESSLVRTALAWLQCLKGEYNSSFITYANMQTDFGENSSFRLPSKARDSQSIIILNGISVIHMQRQHWNDAYELLLNAYKIDPKCQVTLSNLITCSYFLNLKDEPEKYLNELSSVNCNHYKIACVEAIDKSFNAFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQQ7</accession>
    <name>A3FQQ7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_4230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAZ51219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388086.1">
        <property type="nucleotide sequence ID" value="XM_001388049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQQ7"/>
    <dbReference type="STRING" id="353152.A3FQQ7"/>
    <dbReference type="GeneID" id="3372410"/>
    <dbReference type="KEGG" id="cpv:cgd4_4230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4230"/>
    <dbReference type="InParanoid" id="A3FQQ7"/>
    <dbReference type="OMA" id="EFRLNIC"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="17"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="217"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="542"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="800" mass="91437" checksum="8B82F67E56B70003" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPG1</accession>
    <name>Q5CPG1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Domain KOG1666, V-SNARE (Intracellular trafficking, secretion, and vesicular transport)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625332.1">
        <property type="nucleotide sequence ID" value="XM_625332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPG1"/>
    <dbReference type="FunCoup" id="Q5CPG1">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="GeneID" id="3372333"/>
    <dbReference type="KEGG" id="cpv:cgd3_180"/>
    <dbReference type="InParanoid" id="Q5CPG1"/>
    <dbReference type="OMA" id="QETHKVG"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="170" mass="20240" checksum="99224AE0E543141D" modified="2005-04-12" version="1">MTLSKNSIEYQSYQRYQRVYEDIYRKFDTYREESMASSYYSNKELDMSTNISGNDGQNYLKPSTKEYNMGVSTEDLMKRNEDNLRISANLAQETQHIGLYSLNTLTVQRDNLTRSKYGLNNIDYNIMESRKLASTLYKQKVIERLMLYFIIFVLLLANIYVFFRRILGRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPK2</accession>
    <name>Q5CPK2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">CAAX prenyl protease</fullName>
            <ecNumber evidence="14">3.4.24.84</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">cgd6_70</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Proteolytically removes the C-terminal three residues of farnesylated proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11 14">
            <text>Hydrolyzes the peptide bond -P2-(S-farnesyl or geranylgeranyl)C-P1'-P2'-P3'-COOH where P1' and P2' are amino acids with aliphatic side chains and P3' is any C-terminal residue.</text>
            <dbReference type="EC" id="3.4.24.84"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13 14">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="13 14">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the peptidase M48A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.24.84" evidence="14"/>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625347.1">
        <property type="nucleotide sequence ID" value="XM_625347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPK2"/>
    <dbReference type="STRING" id="353152.Q5CPK2"/>
    <dbReference type="GeneID" id="3375666"/>
    <dbReference type="KEGG" id="cpv:cgd6_70"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_70"/>
    <dbReference type="InParanoid" id="Q5CPK2"/>
    <dbReference type="OMA" id="FVIEEKF"/>
    <dbReference type="OrthoDB" id="360839at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071586">
        <property type="term" value="P:CAAX-box protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07343">
        <property type="entry name" value="M48A_Zmpste24p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.10:FF:000002">
        <property type="entry name" value="CAAX prenyl protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.10">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027057">
        <property type="entry name" value="CAXX_Prtase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001915">
        <property type="entry name" value="Peptidase_M48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032456">
        <property type="entry name" value="Peptidase_M48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10120">
        <property type="entry name" value="CAAX PRENYL PROTEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01435">
        <property type="entry name" value="Peptidase_M48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16491">
        <property type="entry name" value="Peptidase_M48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 13 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2 14" id="KW-0645">Protease</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7 13 14" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="112"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="184"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="299"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="340"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 1 N-terminal" evidence="16">
        <location>
            <begin position="52"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M48" evidence="15">
        <location>
            <begin position="218"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="active site" evidence="12">
        <location>
            <position position="287"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="12">
        <location>
            <position position="374"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="290"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="370"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR627057-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF01435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAK87335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="432" mass="49977" checksum="8ADEED00CE2B9035" modified="2007-04-03" version="1">MQTIIGNKLVQGIFLINLIKYLLYLYVDLRQKKCYDIKEIPKYILDAYKDCGEVSNEEFKKSQSYSNSKMVFGLISRAVTFVINWLFVFYVIYPLMWEIIYTRISSNEYVSSLLFCGAMMLLDYPISLAFDLYYTFVLEEKYGFNNSTLKIFIMDQIKSGLLVTVFGTILLSVMIYIANNTGKYFYVYIALVQFGFIFIFSIIYPIIIVPIFNKLTPVENQELAEKISKLCKDVNFPLKNLYQMDASLRSNHGNAFFSGAFKSKSIILYDTILDFPQDEIVAIIGHEIGHWKNWDNYKLLFFSFIQTFVTLFIFHLTFSWNGLYLSFGFSLDPKLGGRNLVLSLLVFSYVLGPFSSIVGILHSIMSQHAEYKADEFSFNLGFGDFLANSLFRLSKKSSSCMIFDPIYSFIHLSHPTVCDRIVSLKKLKDKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPK9</accession>
    <name>Q5CPK9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide, serine proline rich, possible low mw mucin glycoprotein locus of 6 genes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625412.1">
        <property type="nucleotide sequence ID" value="XM_625412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPK9"/>
    <dbReference type="STRING" id="353152.Q5CPK9"/>
    <dbReference type="GeneID" id="3372376"/>
    <dbReference type="KEGG" id="cpv:cgd2_450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_450"/>
    <dbReference type="InParanoid" id="Q5CPK9"/>
    <dbReference type="OrthoDB" id="344336at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254787" evidence="2">
        <location>
            <begin position="24"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="141"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="182" mass="19346" checksum="F20050088E41F194" modified="2005-04-12" version="1">MNTVKLNFIPLVLCLAFLSNFLGIHDQILSLNTHVDHSLIKLSSPRRFLRRLCCCCSSSCSSDDSCCSSSSNRGSIEIGNPTQPKHVWSVTGYYGGFGEEMPTEPPRTQEGDGGNEQSEESEKKSSCCSSSSCKSKKLKLNNGDSNGDSNNDGNSGGNGGRGGPPNPYAGYTGSSNPTFTTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPP2</accession>
    <name>Q5CPP2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter with 9x transmembrande domains and 2xAAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd2_90</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625379.1">
        <property type="nucleotide sequence ID" value="XM_625379.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CPP2">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPP2"/>
    <dbReference type="GeneID" id="3372372"/>
    <dbReference type="KEGG" id="cpv:cgd2_90"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_90"/>
    <dbReference type="InParanoid" id="Q5CPP2"/>
    <dbReference type="OMA" id="RTYIDPY"/>
    <dbReference type="OrthoDB" id="4865934at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="86"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="345"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="945"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="994"/>
            <end position="1013"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1069"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1093"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="91"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="596"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="993"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1307"/>
            <end position="1600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK87388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1616" mass="182461" checksum="261AA657544D260A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPR7</accession>
    <name>Q5CPR7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Origin recognition complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_4320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">ORC is composed of six subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC6/cdc18 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the ORC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625447.1">
        <property type="nucleotide sequence ID" value="XM_625447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPR7"/>
    <dbReference type="STRING" id="353152.Q5CPR7"/>
    <dbReference type="GeneID" id="3372387"/>
    <dbReference type="KEGG" id="cpv:cgd4_4320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4320"/>
    <dbReference type="InParanoid" id="Q5CPR7"/>
    <dbReference type="OMA" id="CINIFTI"/>
    <dbReference type="OrthoDB" id="340077at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049945">
        <property type="entry name" value="AAA_22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041083">
        <property type="entry name" value="AAA_lid_10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF23">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13401">
        <property type="entry name" value="AAA_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17872">
        <property type="entry name" value="AAA_lid_10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="405"/>
            <end position="573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="868" mass="99828" checksum="7C316EA436B7E242" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPV4</accession>
    <name>Q5CPV4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625525.1">
        <property type="nucleotide sequence ID" value="XM_625525.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPV4"/>
    <dbReference type="GeneID" id="3372465"/>
    <dbReference type="KEGG" id="cpv:cgd8_660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_660"/>
    <dbReference type="InParanoid" id="Q5CPV4"/>
    <dbReference type="OMA" id="FITQTHE"/>
    <dbReference type="OrthoDB" id="6129702at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16306">
        <property type="entry name" value="TRANSLIN-ASSOCIATED FACTOR X-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16306:SF0">
        <property type="entry name" value="TRANSLIN-ASSOCIATED FACTOR X-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1441"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="507"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="528"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="543"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1350"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1456"/>
            <end position="1530"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1667" mass="181267" checksum="F99189DD6A58F527" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPV9</accession>
    <name>Q5CPV9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Replication factor C subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd8_610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="10">Iowa type II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625520.1">
        <property type="nucleotide sequence ID" value="XM_625520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPV9"/>
    <dbReference type="FunCoup" id="Q5CPV9">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPV9"/>
    <dbReference type="GeneID" id="3372477"/>
    <dbReference type="KEGG" id="cpv:cgd8_610"/>
    <dbReference type="InParanoid" id="Q5CPV9"/>
    <dbReference type="OMA" id="LICNERN"/>
    <dbReference type="OrthoDB" id="446168at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17748">
        <property type="entry name" value="BRCT_DNA_ligase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000395">
        <property type="entry name" value="Replication factor C subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013725">
        <property type="entry name" value="DNA_replication_fac_RFC1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012178">
        <property type="entry name" value="RFC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF6">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25361">
        <property type="entry name" value="AAA_lid_RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08519">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036578">
        <property type="entry name" value="RFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="9">
        <location>
            <begin position="144"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="36"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="792"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="799"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="814"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="874" mass="97200" checksum="6F1B272E080F8EA7" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPX5</accession>
    <name>Q5CPX5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L7a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the ribosome.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625504.1">
        <property type="nucleotide sequence ID" value="XM_625504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPX5"/>
    <dbReference type="FunCoup" id="Q5CPX5">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPX5"/>
    <dbReference type="GeneID" id="3372471"/>
    <dbReference type="KEGG" id="cpv:cgd8_430"/>
    <dbReference type="InParanoid" id="Q5CPX5"/>
    <dbReference type="OMA" id="RMVKWPA"/>
    <dbReference type="OrthoDB" id="29563at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000003">
        <property type="entry name" value="60S ribosomal protein L7a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001921">
        <property type="entry name" value="Ribosomal_eL8_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00882">
        <property type="entry name" value="RIBOSOMALL7A"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="6">
        <location>
            <begin position="122"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="8"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="263" mass="29818" checksum="2CECD45CEC1E583B" modified="2005-04-12" version="1" fragment="single">ELVKMVASNKSGQNKKNTSTQKVRHPLIEKTSRNFRLGGDIRPKTDLTRYVRYPRYILLQRQKSTLMRRLKVPPTLNQFTCTLDKNQSSQLLRLMGKYKPETRAEKKARLQEEAKKAAAGETTESKKPLFLKYGVNHVTDLVEMKKAKLVVIASDVDPIEIVCFLPALCRRKDVAFCIIGGKARLGKLIGKKTAAVVAIEGVRKEDQAEFDLLCNNFRAQYNDNVELRRKWGGGIMGVKAQHVIKRREKILAMEQAKKVGLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ18</accession>
    <name>Q5CQ18_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CpTSP7 extracellular membrane associated protein with a signal peptide followed by 2 TSP1 repeats, an EGF domain and a transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_4470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625608.1">
        <property type="nucleotide sequence ID" value="XM_625608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ18"/>
    <dbReference type="GeneID" id="3372551"/>
    <dbReference type="KEGG" id="cpv:cgd5_4470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4470"/>
    <dbReference type="InParanoid" id="Q5CQ18"/>
    <dbReference type="OMA" id="FFMAGTI"/>
    <dbReference type="OrthoDB" id="372508at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000019">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF30">
        <property type="entry name" value="SPONDIN-LIKE TSP1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="564"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="522"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="548"/>
            <end position="557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="656" mass="73669" checksum="714776364F661E93" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ91</accession>
    <name>Q5CQ91_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein with 8 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd5_3690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625535.1">
        <property type="nucleotide sequence ID" value="XM_625535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ91"/>
    <dbReference type="STRING" id="353152.Q5CQ91"/>
    <dbReference type="GeneID" id="3372543"/>
    <dbReference type="KEGG" id="cpv:cgd5_3690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3690"/>
    <dbReference type="InParanoid" id="Q5CQ91"/>
    <dbReference type="OMA" id="FRPWRRY"/>
    <dbReference type="OrthoDB" id="10266980at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006634">
        <property type="entry name" value="TLC-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050846">
        <property type="entry name" value="TLCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439">
        <property type="entry name" value="CT120 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13439:SF0">
        <property type="entry name" value="TOPOISOMERASE I DAMAGE AFFECTED PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03798">
        <property type="entry name" value="TRAM_LAG1_CLN8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00724">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50922">
        <property type="entry name" value="TLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="142"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="202"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="TLC" evidence="8">
        <location>
            <begin position="68"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="324" mass="38065" checksum="428170F86E672D65" modified="2005-04-12" version="1">MDAEAIRLINEREGYNFSRCYVFILTIFFGFFFLYLERIKTERVLYLFIPSRVKKLISEGIKSEKKEIKKWNLRIRGISLIHALLSTIFSIIVLFSREIRQDPYSGKPNFWLITSSYSMGYFLWDVSIIIREWNQNKDSVVWFFHGFVSLISLSTSYFISEQPLIEILSLGIITEFSTVILSIRYCYHIIGDTTSLSCKLVSYLFLVAFFFTRNIILPYAFHTQMFNAFKFGPTFKSKARVCIFFPIGELFNIMNIYWLYKVVKNVFNPNDVPDNSGKKECNKPQLDDIDELQIPESQNNILLDSRQNTSEVDTEFDSSKEKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQC7</accession>
    <name>Q5CQC7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625721.1">
        <property type="nucleotide sequence ID" value="XM_625721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQC7"/>
    <dbReference type="GeneID" id="3372648"/>
    <dbReference type="KEGG" id="cpv:cgd4_1240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1240"/>
    <dbReference type="InParanoid" id="Q5CQC7"/>
    <dbReference type="OMA" id="QININAI"/>
    <dbReference type="OrthoDB" id="341516at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="922" mass="106533" checksum="E0E679AF616AEC99" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQI7</accession>
    <name>Q5CQI7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625661.1">
        <property type="nucleotide sequence ID" value="XM_625661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQI7"/>
    <dbReference type="GeneID" id="3372756"/>
    <dbReference type="KEGG" id="cpv:cgd4_560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_560"/>
    <dbReference type="InParanoid" id="Q5CQI7"/>
    <dbReference type="OMA" id="KHEHSNE"/>
    <dbReference type="OrthoDB" id="340920at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="305" mass="35520" checksum="B0AE0D1D06F51805" modified="2005-04-12" version="1">MNTPTKKNTQDKVNDESLLGSYYRLKSYKKLTSNKKSTINGEVSNQNIDENAIYTTPIRSSRRISSRKNYAKEEPNLLDYSPDSKNGKILVTPNPYIGDDIVEELLNDMLLKYKDKIQIINFNKQPQILDEINKDEIEDLYTKFDSKLQINDSNTRTIHSIEKETFESQEEINCEDKNEEKNQEIEDKKLKPILPKLAGKKEYFVCRNKPRKFIGGGTVTNSILVNNTCKYEIIAENEYWMVVEFPKNSSLYRKHNCPRVLTQKRIFGSPVNFPAVQSIDEYKTLHSELKQLLELSNYCYSPDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQK7</accession>
    <name>Q5CQK7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein with possible conserved beta tubulin folding factor domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625641.1">
        <property type="nucleotide sequence ID" value="XM_625641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQK7"/>
    <dbReference type="SMR" id="Q5CQK7"/>
    <dbReference type="GeneID" id="3372740"/>
    <dbReference type="KEGG" id="cpv:cgd4_340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_340"/>
    <dbReference type="InParanoid" id="Q5CQK7"/>
    <dbReference type="OMA" id="IDSTECY"/>
    <dbReference type="OrthoDB" id="337973at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="2">
        <location>
            <begin position="381"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="607" mass="71070" checksum="7055B420B93DFBA1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQL0</accession>
    <name>Q5CQL0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Lipase/esterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625638.1">
        <property type="nucleotide sequence ID" value="XM_625638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQL0"/>
    <dbReference type="STRING" id="353152.Q5CQL0"/>
    <dbReference type="ESTHER" id="crypv-q5cql0">
        <property type="family name" value="Hormone-sensitive_lipase_like"/>
    </dbReference>
    <dbReference type="GeneID" id="3372741"/>
    <dbReference type="KEGG" id="cpv:cgd4_300"/>
    <dbReference type="InParanoid" id="Q5CQL0"/>
    <dbReference type="OMA" id="MGLCSQF"/>
    <dbReference type="OrthoDB" id="408631at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013094">
        <property type="entry name" value="AB_hydrolase_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050300">
        <property type="entry name" value="GDXG_lipolytic_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081">
        <property type="entry name" value="AB HYDROLASE SUPERFAMILY PROTEIN C4A8.06C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48081:SF8">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-3 DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07859">
        <property type="entry name" value="Abhydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha/beta hydrolase fold-3" evidence="2">
        <location>
            <begin position="99"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="342" mass="39915" checksum="E7FD6CB8D7335758" modified="2005-04-12" version="1">MGNRHWIEFDEFGELTDGISMDMDRQINKDDLVVNFIVSKELLERNYKLKQNLTRPIKCSTKKFCSDLYFNESKVKIIYENDNISTHNIDSKTESPGIVIFVHGGGFVFGDFDTYERTLQRHAIELGKLNKPSVIAYIEYRKSPKWRYPIPLEDVIASISWIHCNAEKFGLDPNKLVILGDSAGGNLATSSIASCLSIKDQNKRRNNSLTKKYHNYCKWVDHVKFLGLIYPALCQKCITNSKLKNFRFGFLNLNSLLWFEKQYQSKYIENYFDWRSQPLLAPANILRKFPKTSIVLMKSDILYDEGRLMYEILLKLKVNVKLKIFTGEFINFLNQQKITHFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQR0</accession>
    <name>Q5CQR0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625942.1">
        <property type="nucleotide sequence ID" value="XM_625942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQR0"/>
    <dbReference type="GeneID" id="3372805"/>
    <dbReference type="KEGG" id="cpv:cgd4_3660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3660"/>
    <dbReference type="InParanoid" id="Q5CQR0"/>
    <dbReference type="OrthoDB" id="10412145at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="150" mass="17891" checksum="3B39C67806364F6A" modified="2005-04-12" version="1">MNLKWACFNNVSILHLKANYLNLEGGSEFEDTESQEPLSSSEEYLRLSKIQLDHSEEEEEKEEEEEEEEKKTERMSCRSINILFAHMEEAKSEFSYRVYCYDNLKLGQNCENFLDELVAMCKQIKYLRFPLCGRIIKSHKYVKRMKKKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR54</accession>
    <name>Q5CR54_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SMART RPR domain at NH2 terminus, SMART AZnF_C2H2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625798.1">
        <property type="nucleotide sequence ID" value="XM_625798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR54"/>
    <dbReference type="SMR" id="Q5CR54"/>
    <dbReference type="GeneID" id="3372759"/>
    <dbReference type="KEGG" id="cpv:cgd4_2040"/>
    <dbReference type="InParanoid" id="Q5CR54"/>
    <dbReference type="OMA" id="EDQRQYA"/>
    <dbReference type="OrthoDB" id="343582at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006369">
        <property type="term" value="P:termination of RNA polymerase II transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16982">
        <property type="entry name" value="CID_Pcf11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045154">
        <property type="entry name" value="PCF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047415">
        <property type="entry name" value="Pcf11_CID"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921:SF3">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX 2 PROTEIN PCF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15921">
        <property type="entry name" value="PRE-MRNA CLEAVAGE COMPLEX II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="2">
        <location>
            <begin position="9"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="972" mass="109122" checksum="2B7FDF153F597343" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRJ8</accession>
    <name>Q5CRJ8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Cyclin-dependent kinase 2 homolog</fullName>
            <ecNumber evidence="5">2.7.11.22</ecNumber>
            <ecNumber evidence="4">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="19">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="20">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">cgd5_2510</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="29" key="2">
        <citation type="submission" date="2007-07" db="PDB data bank">
            <title>Cryptosporidium parvum cyclin-dependent kinase cgd5_2510 with indirubin 3'-monoxime bound.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Dong A."/>
                <person name="Lew J."/>
                <person name="Lin Y.H."/>
                <person name="Hassanali A."/>
                <person name="Arrowsmith C.H."/>
                <person name="Edwards A.M."/>
                <person name="Weigelt J."/>
                <person name="Sundstrom M."/>
                <person name="Bochkarev A."/>
                <person name="Hui R."/>
                <person name="Artz J.D."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS)</scope>
    </reference>
    <reference evidence="30" key="3">
        <citation type="submission" date="2010-06" db="PDB data bank">
            <title>Cryptosporidium parvum cyclin-dependent kinase cgd5_2510 with ADP bound.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Dong A."/>
                <person name="Lew J."/>
                <person name="Lin Y.H."/>
                <person name="Hassanali A."/>
                <person name="Arrowsmith C.H."/>
                <person name="Edwards A.M."/>
                <person name="Weigelt J."/>
                <person name="Bountra C."/>
                <person name="Bochkarev A."/>
                <person name="Hui R."/>
                <person name="Artz J.D."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 1-293 IN COMPLEX WITH ADP AND MG(2+)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="22">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="21">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>[DNA-directed RNA polymerase] + ATP = phospho-[DNA-directed RNA polymerase] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10216"/>
            <dbReference type="Rhea" id="RHEA-COMP:11321"/>
            <dbReference type="Rhea" id="RHEA-COMP:11322"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43176"/>
            <dbReference type="ChEBI" id="CHEBI:68546"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="17">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="5"/>
    <dbReference type="EC" id="2.7.11.23" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626188.1">
        <property type="nucleotide sequence ID" value="XM_626188.1"/>
    </dbReference>
    <dbReference type="PDB" id="2QKR">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.60 A"/>
        <property type="chains" value="A=1-295"/>
    </dbReference>
    <dbReference type="PDB" id="3NIZ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="A=1-293"/>
    </dbReference>
    <dbReference type="PDBsum" id="2QKR"/>
    <dbReference type="PDBsum" id="3NIZ"/>
    <dbReference type="AlphaFoldDB" id="Q5CRJ8"/>
    <dbReference type="SMR" id="Q5CRJ8"/>
    <dbReference type="FunCoup" id="Q5CRJ8">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRJ8"/>
    <dbReference type="GeneID" id="3373206"/>
    <dbReference type="KEGG" id="cpv:cgd5_2510"/>
    <dbReference type="InParanoid" id="Q5CRJ8"/>
    <dbReference type="OMA" id="YLYQITR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CRJ8"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000184">
        <property type="entry name" value="cyclin-dependent kinase 5 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000027">
        <property type="entry name" value="Putative Cyclin-dependent kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF46">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="29 30" id="KW-0002">3D-structure</keyword>
    <keyword evidence="14 24 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-0132">Cell division</keyword>
    <keyword evidence="13 27" id="KW-0418">Kinase</keyword>
    <keyword evidence="15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 30" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0498">Mitosis</keyword>
    <keyword evidence="11 24 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 25" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="5"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="15"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="24">
        <location>
            <position position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="81"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="86"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="27">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00049280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EAK88218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="29">
        <source>
            <dbReference type="PDB" id="2QKR"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="30">
        <source>
            <dbReference type="PDB" id="3NIZ"/>
        </source>
    </evidence>
    <sequence length="295" mass="33845" checksum="C164EBBC1E2136A2" modified="2005-04-12" version="1" fragment="single">LMEKYQKLEKVGEGTYGVVYKAKDSQGRIVALKRIRLDAEDEGIPSTAIREISLLKELHHPNIVSLIDVIHSERCLTLVFEFMEKDLKKVLDENKTGLQDSQIKIYLYQLLRGVAHCHQHRILHRDLKPQNLLINSDGALKLADFGLARAFGIPVRSYTHEVVTLWYRAPDVLMGSKKYSTSVDIWSIGCIFAEMITGKPLFPGVTDDDQLPKIFSILGTPNPREWPQVQELPLWKQRTFQVFEKKPWSSIIPGFCQEGIDLLSNMLCFDPNKRISARDAMNHPYFKDLDPQIMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRR4</accession>
    <name>Q5CRR4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MJ1625/yease Yp1009cp-like HhH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_1780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NEMF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626122.1">
        <property type="nucleotide sequence ID" value="XM_626122.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRR4"/>
    <dbReference type="GeneID" id="3373087"/>
    <dbReference type="KEGG" id="cpv:cgd5_1780"/>
    <dbReference type="InParanoid" id="Q5CRR4"/>
    <dbReference type="OMA" id="DICAMVH"/>
    <dbReference type="OrthoDB" id="207084at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.310.10">
        <property type="entry name" value="ibrinogen binding protein from staphylococcus aureus domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021846">
        <property type="entry name" value="NFACT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008532">
        <property type="entry name" value="NFACT_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051608">
        <property type="entry name" value="RQC_Subunit_NEMF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239">
        <property type="entry name" value="NUCLEAR EXPORT MEDIATOR FACTOR NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15239:SF6">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT NEMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11923">
        <property type="entry name" value="NFACT-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05670">
        <property type="entry name" value="NFACT-R_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05833">
        <property type="entry name" value="NFACT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NFACT RNA-binding" evidence="6">
        <location>
            <begin position="586"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="domain" description="NFACT protein C-terminal" evidence="7">
        <location>
            <begin position="1270"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="734"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="900"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="946"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1121"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="734"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="767"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="946"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="963"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1121"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1154"/>
            <end position="1169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1181"/>
            <end position="1196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1204"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1223"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1236"/>
            <end position="1247"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008318"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1378" mass="157916" checksum="5870AA61C55A859D" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS05</accession>
    <name>Q5CS05_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626031.1">
        <property type="nucleotide sequence ID" value="XM_626031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS05"/>
    <dbReference type="FunCoup" id="Q5CS05">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="GeneID" id="3373141"/>
    <dbReference type="KEGG" id="cpv:cgd5_770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_770"/>
    <dbReference type="InParanoid" id="Q5CS05"/>
    <dbReference type="OrthoDB" id="340143at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="212" mass="24328" checksum="17E379897F045A07" modified="2005-04-12" version="1">MKLFLKCKKHLILYFNLIIFSIKSGKSLSNNNNFTPTRDFGTLFNYKNFQELNKNIPNSGELNLFAENIQANRIYEKNDFEKKFKTKEKNTVNRTRGSSTNELHKFSKYWLKKLGIPKEVPPSAWCSEDGVIVGIPITKNVSKILNEKIKSINGREVPVITEDFLDNFFEQNYNGQLYSKGLNIACSGKAVISNSFYEISGKFEGKNNNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS16</accession>
    <name>Q5CS16_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Articulin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626020.1">
        <property type="nucleotide sequence ID" value="XM_626020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS16"/>
    <dbReference type="STRING" id="353152.Q5CS16"/>
    <dbReference type="GeneID" id="3373307"/>
    <dbReference type="KEGG" id="cpv:cgd5_640"/>
    <dbReference type="InParanoid" id="Q5CS16"/>
    <dbReference type="OMA" id="IIQRHVP"/>
    <dbReference type="OrthoDB" id="371494at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022086">
        <property type="entry name" value="IMCp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12314">
        <property type="entry name" value="IMCp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="351" mass="40873" checksum="882A5CBBC82418F9" modified="2005-04-12" version="1" fragment="single">ERVVEKPKVINEEEIVEIETIEYREKLVEVPEIIYKENIIKVPKIEIQERIIEVPKINEEEKIVYVPEVRYVEKFVEKKERVLKEKTVFVPRVEVQERIVEVPKIVIEEKIVEVPQIQYKEVIMEKILEIPQIQEEIVWKDVVVPNIQPRYIETEKIVEIPVVQTIEKLVHASVPQYKMIKQDINVPIVDIKTVPKDCVLEKLKYVPVPVDRYQEVQVPKYVLKTVEVPVPVPIEKIVEEEVPVPISVEKVVHVPKIIQRHVPRTFNVPIPVYSDALIESRVGLMPYNTFLSINHESAEESSQQLTPPNNISHIQQNIQARSSYGTGVEVSSSISLFKSPEREAEDRDYLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS58</accession>
    <name>Q5CS58_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ferlin like type II membrane associated protein with 5 C2 domains and a transmembrane domain or GPI anchor sequence at the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd5_130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625978.1">
        <property type="nucleotide sequence ID" value="XM_625978.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS58"/>
    <dbReference type="GeneID" id="3373202"/>
    <dbReference type="KEGG" id="cpv:cgd5_130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_130"/>
    <dbReference type="InParanoid" id="Q5CS58"/>
    <dbReference type="OMA" id="RICFTIC"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF33">
        <property type="entry name" value="SPERM VESICLE FUSION PROTEIN FER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1899"/>
            <end position="1920"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="167"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="558"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="1677"/>
            <end position="1815"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1301"/>
            <end position="1339"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1315"/>
            <end position="1325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1921" mass="217839" checksum="A9A46A2B4360BDB1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS80</accession>
    <name>Q5CS80_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628187.1">
        <property type="nucleotide sequence ID" value="XM_628187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS80"/>
    <dbReference type="STRING" id="353152.Q5CS80"/>
    <dbReference type="GeneID" id="3371511"/>
    <dbReference type="KEGG" id="cpv:cgd1_3760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3760"/>
    <dbReference type="InParanoid" id="Q5CS80"/>
    <dbReference type="OMA" id="PHELNIN"/>
    <dbReference type="OrthoDB" id="342758at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="675"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="748"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="675"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="690"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="754"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1159" mass="134706" checksum="D8F44CCF089F73AD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSC3</accession>
    <name>Q5CSC3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ring domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_3300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Iowa type II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628144.1">
        <property type="nucleotide sequence ID" value="XM_628144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSC3"/>
    <dbReference type="FunCoup" id="Q5CSC3">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSC3"/>
    <dbReference type="GeneID" id="3371455"/>
    <dbReference type="KEGG" id="cpv:cgd1_3300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3300"/>
    <dbReference type="InParanoid" id="Q5CSC3"/>
    <dbReference type="OMA" id="NYDCPVC"/>
    <dbReference type="OrthoDB" id="5963at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015877">
        <property type="entry name" value="MAT1_centre"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12683:SF13">
        <property type="entry name" value="CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06391">
        <property type="entry name" value="MAT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="15"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="296" mass="34584" checksum="8F0061A207AE181C" modified="2005-04-12" version="1">MNEDIWKDGQKQYSCPLCMTSTYYKNDIKMYYGDPCGHKFCSECSTKANNNKKSTSILRGSNQICPVCHGFVKYIADFEYGETDFLKFESQARKQVYTILNETRKDFKDTPCYDNYLEKREDLIYKLIYGNDTEKKSTQDFLNQYSKENQVAILDRKTREETLLRNDILEIVQKEGTFYEQLNQLSQNTTIDHLQIVHPLQNEYPEFFQNFNKNSNNQNNSNNQNIALGSNIPNPIDKNITCKEYLHQNAKKSNVSTYSSIESKQRAGGFTENIVWSLCKNELFFGFYACHHDSNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSE1</accession>
    <name>Q5CSE1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_3100</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628126.1">
        <property type="nucleotide sequence ID" value="XM_628126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSE1"/>
    <dbReference type="GeneID" id="3371471"/>
    <dbReference type="KEGG" id="cpv:cgd1_3100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3100"/>
    <dbReference type="InParanoid" id="Q5CSE1"/>
    <dbReference type="OMA" id="CEKHERD"/>
    <dbReference type="OrthoDB" id="4703at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052416">
        <property type="entry name" value="GTF3C_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15052">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="610" mass="69702" checksum="330EBD6EF579A728" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSE8</accession>
    <name>Q5CSE8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_3030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628119.1">
        <property type="nucleotide sequence ID" value="XM_628119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSE8"/>
    <dbReference type="STRING" id="353152.Q5CSE8"/>
    <dbReference type="GeneID" id="3371711"/>
    <dbReference type="KEGG" id="cpv:cgd1_3030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3030"/>
    <dbReference type="InParanoid" id="Q5CSE8"/>
    <dbReference type="OMA" id="DSEWITR"/>
    <dbReference type="OrthoDB" id="286790at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061700">
        <property type="term" value="C:GATOR2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16693">
        <property type="entry name" value="mRING-H2-C3H3C2_WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037590">
        <property type="entry name" value="WDR24"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46200:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="820" mass="92731" checksum="F064DB0E80B80C0B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSG0</accession>
    <name>Q5CSG0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">13 kDa membrane protein subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_2880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628107.1">
        <property type="nucleotide sequence ID" value="XM_628107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSG0"/>
    <dbReference type="STRING" id="353152.Q5CSG0"/>
    <dbReference type="GeneID" id="3371346"/>
    <dbReference type="KEGG" id="cpv:cgd1_2880"/>
    <dbReference type="InParanoid" id="Q5CSG0"/>
    <dbReference type="OMA" id="MHKHDLA"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="77" mass="8835" checksum="52BE2A45E1D0D261" modified="2005-04-12" version="1" fragment="single">RMAATFGAHNMHKHDLATKPHLMKQIRSGFDIRTQSKFLIIKHRQLSTHPSNYVENTAIRTSIIISHNLEQICATID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSG9</accession>
    <name>Q5CSG9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AAA superfamily ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628098.1">
        <property type="nucleotide sequence ID" value="XM_628098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSG9"/>
    <dbReference type="STRING" id="353152.Q5CSG9"/>
    <dbReference type="GeneID" id="3371723"/>
    <dbReference type="KEGG" id="cpv:cgd1_2750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2750"/>
    <dbReference type="InParanoid" id="Q5CSG9"/>
    <dbReference type="OMA" id="FIERWNI"/>
    <dbReference type="OrthoDB" id="10251412at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="1">
        <location>
            <begin position="380"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="631" mass="71907" checksum="86B31C4176E4EE6B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSL4</accession>
    <name>Q5CSL4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">K+/H+ antiporter of possible bacterial origin, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd1_2190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628053.1">
        <property type="nucleotide sequence ID" value="XM_628053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSL4"/>
    <dbReference type="STRING" id="353152.Q5CSL4"/>
    <dbReference type="GeneID" id="3371677"/>
    <dbReference type="KEGG" id="cpv:cgd1_2190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2190"/>
    <dbReference type="InParanoid" id="Q5CSL4"/>
    <dbReference type="OMA" id="WFNESIC"/>
    <dbReference type="OrthoDB" id="1654420at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00102">
        <property type="entry name" value="IPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002909">
        <property type="entry name" value="IPT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045158">
        <property type="entry name" value="KEA4/5/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038770">
        <property type="entry name" value="Na+/solute_symporter_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16254">
        <property type="entry name" value="POTASSIUM/PROTON ANTIPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16254:SF14">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01833">
        <property type="entry name" value="TIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0050">Antiport</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="401"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="484"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="513"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="541"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="612"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="643"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="703"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="729"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="763"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="790"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="IPT/TIG" evidence="11">
        <location>
            <begin position="167"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="10">
        <location>
            <begin position="414"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="977" mass="109117" checksum="851F5A9F0BC7D83C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSM2</accession>
    <name>Q5CSM2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein kinase with WD40 repeat at C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_2110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628045.1">
        <property type="nucleotide sequence ID" value="XM_628045.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSM2"/>
    <dbReference type="GeneID" id="3371647"/>
    <dbReference type="KEGG" id="cpv:cgd1_2110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2110"/>
    <dbReference type="InParanoid" id="Q5CSM2"/>
    <dbReference type="OMA" id="INHEHIN"/>
    <dbReference type="OrthoDB" id="242910at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071561">
        <property type="term" value="C:nucleus-vacuole junction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045162">
        <property type="entry name" value="Vps15-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17583:SF0">
        <property type="entry name" value="PHOSPHOINOSITIDE 3-KINASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="26"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="2">
        <location>
            <begin position="1522"/>
            <end position="1557"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1557" mass="183685" checksum="F8B866A3617A1721" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSM6</accession>
    <name>Q5CSM6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_2050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628041.1">
        <property type="nucleotide sequence ID" value="XM_628041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSM6"/>
    <dbReference type="STRING" id="353152.Q5CSM6"/>
    <dbReference type="GeneID" id="3371356"/>
    <dbReference type="KEGG" id="cpv:cgd1_2050"/>
    <dbReference type="InParanoid" id="Q5CSM6"/>
    <dbReference type="OMA" id="ICIQIER"/>
    <dbReference type="OrthoDB" id="339900at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036265">
        <property type="term" value="P:RNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028884">
        <property type="entry name" value="Trm82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288:SF0">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT WDR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16288">
        <property type="entry name" value="WD40 REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="266" mass="29933" checksum="70F3B7BBF7455987" modified="2005-04-12" version="1" fragment="single">YKPKYICIQIERIMRNIDLISGNNSLFYYNDQLIWFQKNKLFSLSLVDYQQSEIALGNEEDTLVSVNISMDGTATACSSNKVIYIIKICNFSFQLIGRFIHSKRLNISIFKPDTNEVIIGDKFGDLYLLNASSIHSAIKNGRNLPSFDNHSDSEELLNNDMADCIIPKMGHLSTVTCSIVSHDSKLLFTGNKCGKIWVSNIKHLENTLSILCGHGGAISSLCEVKIAEESSKLIISSSLDKRIKLWDYLYGTEIDSINLEVSNIQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSS1</accession>
    <name>Q5CSS1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Domain KOG2577, transcription factor E2F/dimerization partner (TDP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_1560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627996.1">
        <property type="nucleotide sequence ID" value="XM_627996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSS1"/>
    <dbReference type="STRING" id="353152.Q5CSS1"/>
    <dbReference type="GeneID" id="3371610"/>
    <dbReference type="KEGG" id="cpv:cgd1_1560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1560"/>
    <dbReference type="InParanoid" id="Q5CSS1"/>
    <dbReference type="OMA" id="ACASNVQ"/>
    <dbReference type="OrthoDB" id="340676at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="158"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="78"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="92"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="115"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="381"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="395" mass="44328" checksum="DAD773C938434D5A" modified="2005-04-12" version="1">MQHSQQGELGTLQDGSYIQQYDYSPINSPNFEENILLYNDNPVNNAGMLYRSDSIFSESSCVSGYTMMKSSSLTNIPSRNLISDIPPIQSGPARASRNSSNIRRSSTSPPPHMNYPYSPNSYHQSSPYYSNSPSSSPRSLSPSLTSRQSPQLGSEQSRAESGLLLLTEKVIEYAKQSPKYEIDLQSVENKLGVPRRRLYDITNVLEAVGLFTKPRHNIYKLNMDMSSGLLQDEENDENIIFYTKSQLELEQAISKIKDSIQELIQVGQEQGLLYADRETLSKLCPVNTNTIVSISMPIDSSITLNPNQHSYQLLNSILRTKNSHTESGMISVQSQILDSHWSILLKHQSSQLNVDVINGHANILEEIRQTMSPMKQPMQPPNINNPTSIVDNFLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSU6</accession>
    <name>Q5CSU6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_1270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627971.1">
        <property type="nucleotide sequence ID" value="XM_627971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSU6"/>
    <dbReference type="SMR" id="Q5CSU6"/>
    <dbReference type="STRING" id="353152.Q5CSU6"/>
    <dbReference type="MEROPS" id="C97.A01"/>
    <dbReference type="GeneID" id="3371364"/>
    <dbReference type="KEGG" id="cpv:cgd1_1270"/>
    <dbReference type="InParanoid" id="Q5CSU6"/>
    <dbReference type="OMA" id="NEVMRTP"/>
    <dbReference type="OrthoDB" id="21221at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070646">
        <property type="term" value="P:protein modification by small protein removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF7">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="6">
        <location>
            <begin position="17"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="354"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="404" mass="45218" checksum="5C3A53C071F75021" modified="2005-04-12" version="1" fragment="single">DNILNFTVELQMSDIGEKVELHIYDLSNGMASQLSPMLLGRTIEAIYHTGVFVYGYEYFYGGGIVCVRPEEITRLYGLKPIRTLTLGTTKKSQKELNSHLESISNEFNSDNYDLLNHNCNHFSDNIVKFLIGEGIPSYILDLPNEVMRTPFGSMILPMLQKAQKSQAIRSVANVWNTNGINPSNVINKTAEEFSYLSSGSSSTGSSRTSHHSRSSGSSDSISEFSKKLSTVSNKYGWQCQRVLETLETILFNIISNPGDLRYRSIKSTSNTLKSVLMSIDEGLELLFLVGFREKQAEDQLRYEIQLSQPLSREEREQLETQINLVRRTLSSLGMASEQETQESACPESKASNGSKSESTIDYVKLLAEVKGMGFEDNKKILQALHKTNGDISRTVSILLDEQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSW0</accession>
    <name>Q5CSW0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Epsin like ENTH domain (Alpha-alpha superhelix)involved in vesicular transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_1120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627957.1">
        <property type="nucleotide sequence ID" value="XM_627957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSW0"/>
    <dbReference type="STRING" id="353152.Q5CSW0"/>
    <dbReference type="GeneID" id="3371366"/>
    <dbReference type="KEGG" id="cpv:cgd1_1120"/>
    <dbReference type="InParanoid" id="Q5CSW0"/>
    <dbReference type="OMA" id="KDNETHS"/>
    <dbReference type="OrthoDB" id="118154at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032588">
        <property type="term" value="C:trans-Golgi network membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03572">
        <property type="entry name" value="ENTH_like_Tepsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035802">
        <property type="entry name" value="ENTH/VHS_tepsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039273">
        <property type="entry name" value="TEPSIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21514">
        <property type="entry name" value="AP-4 COMPLEX ACCESSORY SUBUNIT TEPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21514:SF0">
        <property type="entry name" value="AP-4 COMPLEX ACCESSORY SUBUNIT TEPSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="6">
        <location>
            <begin position="25"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="584" mass="65723" checksum="0075AC29B178AF0A" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSX3</accession>
    <name>Q5CSX3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="2">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd1_990</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627944.1">
        <property type="nucleotide sequence ID" value="XM_627944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSX3"/>
    <dbReference type="STRING" id="353152.Q5CSX3"/>
    <dbReference type="GeneID" id="3371558"/>
    <dbReference type="KEGG" id="cpv:cgd1_990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_990"/>
    <dbReference type="InParanoid" id="Q5CSX3"/>
    <dbReference type="OMA" id="RESSKCC"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253806" description="proton-translocating NAD(P)(+) transhydrogenase" evidence="15">
        <location>
            <begin position="29"/>
            <end position="1147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="242"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="294"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1036"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1061"/>
            <end position="1079"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1115"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="17">
        <location>
            <begin position="604"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="16">
        <location>
            <begin position="746"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="543"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAK88482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1147" mass="125879" checksum="FB1003F97C3DF3FE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT85</accession>
    <name>Q5CT85_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_4020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626584.1">
        <property type="nucleotide sequence ID" value="XM_626584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT85"/>
    <dbReference type="GeneID" id="3373392"/>
    <dbReference type="KEGG" id="cpv:cgd2_4020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4020"/>
    <dbReference type="InParanoid" id="Q5CT85"/>
    <dbReference type="OrthoDB" id="342411at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="242" mass="28630" checksum="B92404EFAC49A268" modified="2005-04-12" version="1">MKFKQRILFIFVYLFVILQIYIKFEFAGANSVGKLGYYDYNDSNTSDKKLQGKFRKDSSQIRLNFMKYFLNVNKEIELTKKQNNTSINTPFMDFLHAPLSLRTIPKSEEVCSSIQLMSFWKLYNDVFDLVESEFNSILDLDLVQKKASEELYENSLILTQSDEIKQDISEELKNIKNETSSTNINKHRNLIEDHVKPQKNATKTNKKPNKSKNSYINKKKQTKKHKKIKTFEFGFHRYFNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTA5</accession>
    <name>Q5CTA5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical small protein with 2 EF-hand domains, possible</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_3790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626564.1">
        <property type="nucleotide sequence ID" value="XM_626564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTA5"/>
    <dbReference type="GeneID" id="3373403"/>
    <dbReference type="KEGG" id="cpv:cgd2_3790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3790"/>
    <dbReference type="InParanoid" id="Q5CTA5"/>
    <dbReference type="OMA" id="NEYMIFI"/>
    <dbReference type="OrthoDB" id="10263155at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254498" evidence="2">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="26"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="69"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="104" mass="12126" checksum="B35A5D4ACDD180C7" modified="2005-04-12" version="1">MTKGFLTYLFFAILLVINQVIDGVKSELSQTEKEFSEFDLNRDGYIDAQEIRIIRTSVTLQELHQFFWEIDVDNSGTISFHEYSNFVTNNSHAHHNNESNNQHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTC7</accession>
    <name>Q5CTC7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Hypothetical low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd2_3550</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin NSP1/NUP62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626542.1">
        <property type="nucleotide sequence ID" value="XM_626542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTC7"/>
    <dbReference type="STRING" id="353152.Q5CTC7"/>
    <dbReference type="GeneID" id="3373751"/>
    <dbReference type="KEGG" id="cpv:cgd2_3550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3550"/>
    <dbReference type="InParanoid" id="Q5CTC7"/>
    <dbReference type="OMA" id="EMMSKQV"/>
    <dbReference type="OrthoDB" id="344345at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044613">
        <property type="term" value="C:nuclear pore central transport channel"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026010">
        <property type="entry name" value="NSP1/NUP62"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007758">
        <property type="entry name" value="Nucleoporin_NSP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084:SF0">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12084">
        <property type="entry name" value="NUCLEAR PORE GLYCOPROTEIN P62-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05064">
        <property type="entry name" value="Nsp1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nucleoporin NSP1-like C-terminal" evidence="11">
        <location>
            <begin position="626"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="233"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="506"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="725"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="789"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="726"/>
            <end position="761"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="860" mass="85261" checksum="9DD5F39D9FE498D4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTJ5</accession>
    <name>Q5CTJ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Po1 beta superfamily nucleotidyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_2730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626474.1">
        <property type="nucleotide sequence ID" value="XM_626474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTJ5"/>
    <dbReference type="STRING" id="353152.Q5CTJ5"/>
    <dbReference type="GeneID" id="3373475"/>
    <dbReference type="KEGG" id="cpv:cgd2_2730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2730"/>
    <dbReference type="InParanoid" id="Q5CTJ5"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271">
        <property type="entry name" value="POLY A POLYMERASE CID PAP -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12271:SF40">
        <property type="entry name" value="POLY(A) RNA POLYMERASE GLD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="331"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="692"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1162" mass="127043" checksum="6A04766E94CA7421" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTJ9</accession>
    <name>Q5CTJ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Possible MgtA, cation transport ATpase, signal peptide, 12 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_2680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626470.1">
        <property type="nucleotide sequence ID" value="XM_626470.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTJ9"/>
    <dbReference type="TCDB" id="3.A.3.10.18">
        <property type="family name" value="the p-type atpase (p-atpase) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="3373632"/>
    <dbReference type="KEGG" id="cpv:cgd2_2680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2680"/>
    <dbReference type="InParanoid" id="Q5CTJ9"/>
    <dbReference type="OMA" id="LARIEVC"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="15"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="106"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="275"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="523"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1084"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1116"/>
            <end position="1140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1219"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1312"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1380"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="12">
        <location>
            <begin position="363"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1415"/>
            <end position="1434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1416"/>
            <end position="1434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1434" mass="164932" checksum="135834501D6B717B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTK9</accession>
    <name>Q5CTK9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626460.1">
        <property type="nucleotide sequence ID" value="XM_626460.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373642"/>
    <dbReference type="KEGG" id="cpv:cgd2_2580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2580"/>
    <dbReference type="InParanoid" id="Q5CTK9"/>
    <dbReference type="OMA" id="CILATIE"/>
    <dbReference type="OrthoDB" id="339091at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2319" mass="269076" checksum="8E6F0A5C54846779" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTL5</accession>
    <name>Q5CTL5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626454.1">
        <property type="nucleotide sequence ID" value="XM_626454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTL5"/>
    <dbReference type="GeneID" id="3373646"/>
    <dbReference type="KEGG" id="cpv:cgd2_2520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2520"/>
    <dbReference type="InParanoid" id="Q5CTL5"/>
    <dbReference type="OrthoDB" id="344314at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="191" mass="22358" checksum="B2917462631205AC" modified="2005-04-12" version="1">MNIMHRSNVLLYNIECVLEEDKFLEYAFGTNCSEMLVTFDKSIINIIAYKKILHSLESVKLQISGNKELQDDYLGRIEILKLKLEDKLNLELLGDENQPQNIKNLYSHLKPNKNIYEYLESNSTKFAEHSLELPPTSKNNLKPENIDNRLDIKVINERFKDELVELAEEMKCSAFRFQELLRSEKKVSFSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="132" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTT7</accession>
    <name>Q5CTT7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM3</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd2_1600</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626382.1">
        <property type="nucleotide sequence ID" value="XM_626382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTT7"/>
    <dbReference type="FunCoup" id="Q5CTT7">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTT7"/>
    <dbReference type="GeneID" id="3373713"/>
    <dbReference type="KEGG" id="cpv:cgd2_1600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1600"/>
    <dbReference type="InParanoid" id="Q5CTT7"/>
    <dbReference type="OMA" id="NVYPQED"/>
    <dbReference type="OrthoDB" id="1882346at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008046">
        <property type="entry name" value="Mcm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF46">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01659">
        <property type="entry name" value="MCMPROTEIN3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="311"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="700"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="704"/>
            <end position="716"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK88811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="862" mass="96699" checksum="82D66328F0AA23B3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTV2</accession>
    <name>Q5CTV2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_1440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 4">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626367.1">
        <property type="nucleotide sequence ID" value="XM_626367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTV2"/>
    <dbReference type="FunCoup" id="Q5CTV2">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTV2"/>
    <dbReference type="MEROPS" id="T01.974"/>
    <dbReference type="GeneID" id="3373680"/>
    <dbReference type="KEGG" id="cpv:cgd2_1440"/>
    <dbReference type="InParanoid" id="Q5CTV2"/>
    <dbReference type="OMA" id="ICMLDHH"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03755">
        <property type="entry name" value="proteasome_alpha_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000004">
        <property type="entry name" value="Proteasome subunit alpha type-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 3 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="5">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="256" mass="28362" checksum="0273E4E967CF9E2C" modified="2005-04-12" version="1" fragment="single">IILLKRIDNFKIMSLYDRAITVFSPDGHLLQVEYAMEAVRKGYGAIGVRGAECVVLAVERKAVAKLQDPRSAKKLLLVDDNTCLAFAGLHADARVLVNKIRLECQNFRLNIEDAPPVDYIARFTAQQQQKYTHRGGVRPFGVSTLIAGVHNDGSPGLYQTDPSGIALEWKAQAVGQNSKTVQEFLEKNYKHDMAKEETINLAISALLEVVESGSRNMEIVVVDKKGCNFLSDEETDMLVSAIESKIAAENENKTRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTX5</accession>
    <name>Q5CTX5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Trimethylguanosine synthase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Cap-specific guanine-N(2) methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_1190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78479"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="Rhea" id="RHEA-COMP:19089"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:78480"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(2),N(7)-trimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78507"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="Rhea" id="RHEA-COMP:19090"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167623"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:78508"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78471"/>
            <dbReference type="Rhea" id="RHEA-COMP:19085"/>
            <dbReference type="Rhea" id="RHEA-COMP:19087"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:78472"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-methionine = a 5'-end (N(2),N(7)-dimethyl 5'-triphosphoguanosine)-ribonucleoside in snoRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:78475"/>
            <dbReference type="Rhea" id="RHEA-COMP:19086"/>
            <dbReference type="Rhea" id="RHEA-COMP:19088"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:172880"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:78476"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626344.1">
        <property type="nucleotide sequence ID" value="XM_626344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTX5"/>
    <dbReference type="STRING" id="353152.Q5CTX5"/>
    <dbReference type="GeneID" id="3373585"/>
    <dbReference type="KEGG" id="cpv:cgd2_1190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1190"/>
    <dbReference type="InParanoid" id="Q5CTX5"/>
    <dbReference type="OMA" id="ENIMDTR"/>
    <dbReference type="OrthoDB" id="194443at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071164">
        <property type="term" value="F:RNA cap trimethylguanosine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019012">
        <property type="entry name" value="RNA_cap_Gua-N2-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741">
        <property type="entry name" value="S-ADENOSYLMETHIONINE-DEPENDENT METHYLTRANSFERASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14741:SF32">
        <property type="entry name" value="TRIMETHYLGUANOSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09445">
        <property type="entry name" value="Methyltransf_15"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00025783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="620" mass="71370" checksum="710A318D5C95497B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTZ6</accession>
    <name>Q5CTZ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase'insulinase-like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626323.1">
        <property type="nucleotide sequence ID" value="XM_626323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTZ6"/>
    <dbReference type="SMR" id="Q5CTZ6"/>
    <dbReference type="STRING" id="353152.Q5CTZ6"/>
    <dbReference type="GeneID" id="3373649"/>
    <dbReference type="KEGG" id="cpv:cgd2_920"/>
    <dbReference type="InParanoid" id="Q5CTZ6"/>
    <dbReference type="OMA" id="LQSDCWR"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000012">
        <property type="entry name" value="Protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="203"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="11">
        <location>
            <begin position="390"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="12">
        <location>
            <begin position="835"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1028" mass="118706" checksum="A2FA3CF66FCE254E" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="122" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU23</accession>
    <name>Q5CU23_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">T-complex protein 1 subunit alpha</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd2_600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626296.1">
        <property type="nucleotide sequence ID" value="XM_626296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU23"/>
    <dbReference type="FunCoup" id="Q5CU23">
        <property type="interactions" value="528"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU23"/>
    <dbReference type="GeneID" id="3373385"/>
    <dbReference type="KEGG" id="cpv:cgd2_600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_600"/>
    <dbReference type="InParanoid" id="Q5CU23"/>
    <dbReference type="OMA" id="RGPNDYQ"/>
    <dbReference type="OrthoDB" id="496at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03335">
        <property type="entry name" value="TCP1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012715">
        <property type="entry name" value="Chap_CCT_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00014424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00030049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="567" mass="61547" checksum="162C000CCEC2A2D8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU48</accession>
    <name>Q5CU48_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_4230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626966.1">
        <property type="nucleotide sequence ID" value="XM_626966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU48"/>
    <dbReference type="STRING" id="353152.Q5CU48"/>
    <dbReference type="GeneID" id="3374058"/>
    <dbReference type="KEGG" id="cpv:cgd3_4230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4230"/>
    <dbReference type="InParanoid" id="Q5CU48"/>
    <dbReference type="OrthoDB" id="340869at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="558" mass="66451" checksum="07FBEBD832029AFA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU76</accession>
    <name>Q5CU76_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L27A or L27a</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_3930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626938.1">
        <property type="nucleotide sequence ID" value="XM_626938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU76"/>
    <dbReference type="FunCoup" id="Q5CU76">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU76"/>
    <dbReference type="GeneID" id="3373924"/>
    <dbReference type="KEGG" id="cpv:cgd3_3930"/>
    <dbReference type="InParanoid" id="Q5CU76"/>
    <dbReference type="OMA" id="WGRVGQH"/>
    <dbReference type="OrthoDB" id="61900at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L27a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01341">
        <property type="entry name" value="Ribosomal_uL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030878">
        <property type="entry name" value="Ribosomal_uL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001196">
        <property type="entry name" value="Ribosomal_uL15_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11721:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00828">
        <property type="entry name" value="Ribosomal_L27A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00475">
        <property type="entry name" value="RIBOSOMAL_L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="6">
        <location>
            <begin position="80"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="157" mass="17857" checksum="9D5828B06BC24AE8" modified="2005-04-12" version="1" fragment="single">TFLTNIYLYNSRFKKNRKKRGHVSAGHGRVGKHRKHPGGRGACGGLTHKRNWFDKYHPGYFGKVGMRYFHKRLNKMYCPTVNVEKLWTLVSKNTLEHYKYNNKTDKAPIIDCTKSGIFKVLGGGNLPNLPVVVRARHFSKKAEKKIKEAGGICVLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU92</accession>
    <name>Q5CU92_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Multiprotein bridging factor type 1 like transcriptional co-activator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_3750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626922.1">
        <property type="nucleotide sequence ID" value="XM_626922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU92"/>
    <dbReference type="FunCoup" id="Q5CU92">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU92"/>
    <dbReference type="GeneID" id="3373933"/>
    <dbReference type="KEGG" id="cpv:cgd3_3750"/>
    <dbReference type="InParanoid" id="Q5CU92"/>
    <dbReference type="OMA" id="GKNKSCK"/>
    <dbReference type="OrthoDB" id="10253401at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00093">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.40">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001387">
        <property type="entry name" value="Cro/C1-type_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010982">
        <property type="entry name" value="Lambda_DNA-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013729">
        <property type="entry name" value="MBF1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245:SF15">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10245">
        <property type="entry name" value="ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01381">
        <property type="entry name" value="HTH_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08523">
        <property type="entry name" value="MBF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00530">
        <property type="entry name" value="HTH_XRE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47413">
        <property type="entry name" value="lambda repressor-like DNA-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50943">
        <property type="entry name" value="HTH_CROC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH cro/C1-type" evidence="5">
        <location>
            <begin position="92"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="22"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="158" mass="17724" checksum="9666A698D38B0D3A" modified="2005-04-12" version="1" fragment="single">QKITLLNHISKMSQDWNQVVWKKGGSRPKGISKEQDLNQARRKGEEIITEKKFLGGRNASTKQNIPQNAAKLDEDTGDYRIFRVSGEFSRALQQARVAKKLTQAQLAQMINEKASVVNDYESGKAIPNPILVQKMSRCLGVNLPKPAPKKKPDNNNND</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUI9</accession>
    <name>Q5CUI9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_2650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626825.1">
        <property type="nucleotide sequence ID" value="XM_626825.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373971"/>
    <dbReference type="KEGG" id="cpv:cgd3_2650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2650"/>
    <dbReference type="InParanoid" id="Q5CUI9"/>
    <dbReference type="OMA" id="FRSIWMS"/>
    <dbReference type="OrthoDB" id="341415at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1787" mass="210260" checksum="DA7C8F5DEB415B12" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUN8</accession>
    <name>Q5CUN8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626776.1">
        <property type="nucleotide sequence ID" value="XM_626776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUN8"/>
    <dbReference type="GeneID" id="3374044"/>
    <dbReference type="KEGG" id="cpv:cgd3_2070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2070"/>
    <dbReference type="InParanoid" id="Q5CUN8"/>
    <dbReference type="OrthoDB" id="341180at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="159" mass="18475" checksum="68E569EF538470CD" modified="2005-04-12" version="1">MNFEDKVDAKKVEHIKVLPEGESQNSVQSSNGFENVDPKSEPLSEIEAKNEEGGIKRRFQPNKFLKFSNLVLVPGKPRKWKRVQRRFGRSEGAWLYRWEYIPESIDNLFMENLELMARGVVGPRRTGRTTRAVSFHMRENPVGPNHPNLYELEGNYEQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUY6</accession>
    <name>Q5CUY6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CG6144-like AlkB</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626678.1">
        <property type="nucleotide sequence ID" value="XM_626678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUY6"/>
    <dbReference type="STRING" id="353152.Q5CUY6"/>
    <dbReference type="GeneID" id="3373843"/>
    <dbReference type="KEGG" id="cpv:cgd3_990"/>
    <dbReference type="InParanoid" id="Q5CUY6"/>
    <dbReference type="OMA" id="KSPKTKW"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051213">
        <property type="term" value="F:dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032862">
        <property type="entry name" value="ALKBH6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46030:SF1">
        <property type="entry name" value="ALPHA-KETOGLUTARATE-DEPENDENT DIOXYGENASE ALKB HOMOLOG 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="180" mass="21032" checksum="C901302E434D0AB2" modified="2005-04-12" version="1" fragment="single">VNLPIYPIFLLFRVHKLIIYLYYFECLDWITPEQEKTLLENISRSSFLNVKLNGRQTQVWGGTVSESGIVNQKDLPEWLESISQSLVDYNIFSKEETPNHVLINQYEQYKGILPHKDGPLYYPRVAIISLESDTLFDFWNPSLDTQENKFPLFSLIVPKLSLLVFQDLCYTQLLHGISSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUY7</accession>
    <name>Q5CUY7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626677.1">
        <property type="nucleotide sequence ID" value="XM_626677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUY7"/>
    <dbReference type="GeneID" id="3374178"/>
    <dbReference type="KEGG" id="cpv:cgd3_970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_970"/>
    <dbReference type="InParanoid" id="Q5CUY7"/>
    <dbReference type="OMA" id="DFAITMA"/>
    <dbReference type="OrthoDB" id="342944at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="157" mass="17884" checksum="38291C6EFDB471E9" modified="2005-04-12" version="1">MSSTYSTFVSSIGAIETGVMGTLAGGPSYFIPFAIFGYYKTRADVNAATNRMMEIADSSRNPRKNFTRSIKMRNTQEFSGQQNSYFWILTIVAVALGVIAISLLSCLVGITPDDDYRESKKRRRKLMENPKITPEEFAVTMANYTPNEYRYREWNRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV04</accession>
    <name>Q5CV04_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ULP1 like protease with a chlamydin like cysteine protease domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626660.1">
        <property type="nucleotide sequence ID" value="XM_626660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV04"/>
    <dbReference type="STRING" id="353152.Q5CV04"/>
    <dbReference type="GeneID" id="3374134"/>
    <dbReference type="KEGG" id="cpv:cgd3_770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_770"/>
    <dbReference type="InParanoid" id="Q5CV04"/>
    <dbReference type="OrthoDB" id="442460at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46915:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46915">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="1"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="372" mass="43285" checksum="388C564F86E044F8" modified="2005-04-12" version="1">MSVISTNSYLLGQKTINFNGISLGLDKAKKQLMNNSYLDDLILDFFMEFAKELCVGIKENCSKGKYCVFSSLFYTILSMCGDYQDYLRLRKWVKRVSTPLLLNDAIVIPMHCNQTSHWWLIVICHPRKIFNLMNSSSPRNNSTTKIENSNRGWIICMDSLGGKNIGQNEKKKAIINILKFLDIERQNNDSYFNLLEAGNIPTMVYDSVNTKAHNTNTSATHDKLSETFRSLSNWEIIYNPRNLPFQENNFDCGIYIIEYAHLLFHYGTTIFNSMINTSSSSDISYTTHLDQNKFSRNWFQNRRTVYTKVLEFMSNNESWNEDNFLRNKLVEIFDDSIKASNHNEKPSQENISSLQSRRRFVMSSLNKSYFNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV74</accession>
    <name>Q5CV74_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized apicomplexan-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_5160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627395.1">
        <property type="nucleotide sequence ID" value="XM_627395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV74"/>
    <dbReference type="FunCoup" id="Q5CV74">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="3374235"/>
    <dbReference type="KEGG" id="cpv:cgd8_5160"/>
    <dbReference type="InParanoid" id="Q5CV74"/>
    <dbReference type="OMA" id="NECKNFM"/>
    <dbReference type="OrthoDB" id="360590at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="170" mass="18893" checksum="C11E6F70FADA7B52" modified="2005-04-12" version="1">MTVNPAFIPKELTDVYAPGNYDSNCSILACNFPTGTSVEECSNFMSWIGPVVFVEEGPSLQREANFIVVYSKPEFAVKATQEELVFNEGCRVHCRFVDAKPTVWGNITNFFQGIDQQYGASDQISNFINDTAGMFSLFENAYLGLVLVLVLELVFKLKLGVVSLNIKCLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVF8</accession>
    <name>Q5CVF8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627311.1">
        <property type="nucleotide sequence ID" value="XM_627311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVF8"/>
    <dbReference type="GeneID" id="3374545"/>
    <dbReference type="KEGG" id="cpv:cgd8_4210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4210"/>
    <dbReference type="InParanoid" id="Q5CVF8"/>
    <dbReference type="OrthoDB" id="342932at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="85"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="299" mass="35649" checksum="89F9D38F0F04472C" modified="2005-04-12" version="1">MKELIAQSSHTIEYSGTSPRTVSVSLNSLDFGLDSDNCVEEEEERVDEVDKYRSNFSNEYNQLKRIVENIYLALEDHEIGCSFEEVSIRENLEKLFGELENLKEANGKLVEKKEKEISNTMKSIWNEERSLHIKLYDIKKTLNYLALQLMFGKEHQISNKGRNLEINHYTEFRNTMQKFGLSYEEYLEYYTLKRNCDKQEIIMHDYERRINELREIYKIRESYELAQNSCNYYTQNQEYDNDNSNWEVKLKGKNTMEFLSEKNTRLLSENENIIKFLKIKNEFQNKIISNICTIIGITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVH2</accession>
    <name>Q5CVH2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S proteasomal subunit S3 PINT domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_4060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627297.1">
        <property type="nucleotide sequence ID" value="XM_627297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVH2"/>
    <dbReference type="FunCoup" id="Q5CVH2">
        <property type="interactions" value="547"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVH2"/>
    <dbReference type="GeneID" id="3374624"/>
    <dbReference type="KEGG" id="cpv:cgd8_4060"/>
    <dbReference type="InParanoid" id="Q5CVH2"/>
    <dbReference type="OMA" id="AKVYFYF"/>
    <dbReference type="OrthoDB" id="1713558at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050756">
        <property type="entry name" value="CSN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013586">
        <property type="entry name" value="PSMD3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057985">
        <property type="entry name" value="TPR_PSMD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10758">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 3/COP9 SIGNALOSOME COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08375">
        <property type="entry name" value="Rpn3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25573">
        <property type="entry name" value="TPR_PSMD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="PCI" evidence="4">
        <location>
            <begin position="295"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="551" mass="63489" checksum="17A8F216CC653EF2" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVQ3</accession>
    <name>Q5CVQ3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd8_3200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627216.1">
        <property type="nucleotide sequence ID" value="XM_627216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVQ3"/>
    <dbReference type="FunCoup" id="Q5CVQ3">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVQ3"/>
    <dbReference type="MEROPS" id="C12.010"/>
    <dbReference type="GeneID" id="3374243"/>
    <dbReference type="KEGG" id="cpv:cgd8_3200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3200"/>
    <dbReference type="InParanoid" id="Q5CVQ3"/>
    <dbReference type="OMA" id="IDLHYVC"/>
    <dbReference type="OrthoDB" id="427186at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF17">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="7"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="87"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="227" mass="25909" checksum="7ECF78393CF2E1A3" modified="2005-04-12" version="1">MNKKNKIWKPLISDPKLLEEYSVGLGVKSKISFIDIYTTEETEFYFCGINPISLIALVPINDEKICKKRNKLGCEMNISQSVWFMKQYITNSCSAVALLHSILNNDKIELEEESIAKMLLNLKGDPNDLPEERGFYLINDKNIEYLHEELSSRDLTKDCDQSEFHYVSFVNNHGHIIELDGRLPCPISHGVCKSDEFLKNTLKIIKENFILPIGINGKIAIVALCIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVR1</accession>
    <name>Q5CVR1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">12x WD40 repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627208.1">
        <property type="nucleotide sequence ID" value="XM_627208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVR1"/>
    <dbReference type="STRING" id="353152.Q5CVR1"/>
    <dbReference type="GeneID" id="3374335"/>
    <dbReference type="KEGG" id="cpv:cgd8_3110"/>
    <dbReference type="InParanoid" id="Q5CVR1"/>
    <dbReference type="OMA" id="MNTIENT"/>
    <dbReference type="OrthoDB" id="8883818at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046351">
        <property type="entry name" value="UTP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44163:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="950" mass="107463" checksum="87709DFA20C5CDBA" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVT9</accession>
    <name>Q5CVT9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Extracellular protein with a signal peptide, a mucin-like stretch of threonine residues and 6 notch domains possible mucin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_2800</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627180.1">
        <property type="nucleotide sequence ID" value="XM_627180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVT9"/>
    <dbReference type="STRING" id="353152.Q5CVT9"/>
    <dbReference type="GeneID" id="3374342"/>
    <dbReference type="KEGG" id="cpv:cgd8_2800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2800"/>
    <dbReference type="InParanoid" id="Q5CVT9"/>
    <dbReference type="OMA" id="KCHRTER"/>
    <dbReference type="OrthoDB" id="343807at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.320">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035993">
        <property type="entry name" value="Notch-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000800">
        <property type="entry name" value="Notch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047141">
        <property type="entry name" value="Stealth"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24045:SF0">
        <property type="entry name" value="N-ACETYLGLUCOSAMINE-1-PHOSPHOTRANSFERASE SUBUNITS ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00066">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00004">
        <property type="entry name" value="NL"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90193">
        <property type="entry name" value="Notch domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50258">
        <property type="entry name" value="LNR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254563" evidence="9">
        <location>
            <begin position="24"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="10">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="10">
        <location>
            <begin position="200"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="10">
        <location>
            <begin position="275"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="576" mass="65316" checksum="30EBE301E1911BC9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVZ6</accession>
    <name>Q5CVZ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">BRG1/brm-associated factor 53A like actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_2200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627123.1">
        <property type="nucleotide sequence ID" value="XM_627123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVZ6"/>
    <dbReference type="SMR" id="Q5CVZ6"/>
    <dbReference type="STRING" id="353152.Q5CVZ6"/>
    <dbReference type="GeneID" id="3374481"/>
    <dbReference type="KEGG" id="cpv:cgd8_2200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2200"/>
    <dbReference type="InParanoid" id="Q5CVZ6"/>
    <dbReference type="OMA" id="IAYRRCH"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13395">
        <property type="entry name" value="ASKHA_NBD_Arp4_ACTL6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="423" mass="46261" checksum="4B42971279DC92A4" modified="2005-04-12" version="1">MSGKETFIGGDDVGAIIVDVGSCMTKIGYGGEDCPRQVWPSVVGVKENGDKRFPLNFLSYLEDVSVEPCLKYEDGGLILNGDVFEEIIRTTSGKIGLSTDLREHPILLTEPSKHNRQIREKEVEIMFEKFDVPAVYTAKKAILSAFSVGRSSGLVVDIGATATSIVPILDGYTLQKPLCEYPIGGDFLDDQIARHLLKEKNLSISPNFSFKKIIHKDKPLSYESVNLEKVTSSYIEYGKREVLRNIKESICRCAEHEEVAKTSSALATSTYELPDGTLIDSEPIGIRVPECLLNPEMIINDSEFPPVNTNGFPGLCSAISNTIIACDIDIRKDLIGAVILTGGTSIIPGLADRVSKSLAEDDKLSGGGPKLKIISPNSTVERRFSSWIGGSILASLGSFQQMWFSKEEYTEHGAKLVERKCSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW00</accession>
    <name>Q5CW00_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">poly(ADP-ribose) glycohydrolase</fullName>
            <ecNumber evidence="2">3.2.1.143</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_2160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the poly(ADP-ribose) glycohydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.2.1.143" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627119.1">
        <property type="nucleotide sequence ID" value="XM_627119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW00"/>
    <dbReference type="STRING" id="353152.Q5CW00"/>
    <dbReference type="GeneID" id="3374558"/>
    <dbReference type="KEGG" id="cpv:cgd8_2160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2160"/>
    <dbReference type="InParanoid" id="Q5CW00"/>
    <dbReference type="OMA" id="RICRCMP"/>
    <dbReference type="OrthoDB" id="1937899at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004649">
        <property type="term" value="F:poly(ADP-ribose) glycohydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990966">
        <property type="term" value="P:ATP generation from poly-ADP-D-ribose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009225">
        <property type="term" value="P:nucleotide-sugar metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006282">
        <property type="term" value="P:regulation of DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046372">
        <property type="entry name" value="PARG_cat_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048362">
        <property type="entry name" value="PARG_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007724">
        <property type="entry name" value="Poly_GlycHdrlase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837">
        <property type="entry name" value="POLY ADP-RIBOSE GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12837:SF0">
        <property type="entry name" value="POLY(ADP-RIBOSE) GLYCOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05028">
        <property type="entry name" value="PARG_cat_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20811">
        <property type="entry name" value="PARG_cat_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="domain" description="PARG helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="domain" description="PARG catalytic Macro" evidence="5">
        <location>
            <begin position="215"/>
            <end position="393"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF20811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="441" mass="49842" checksum="A5486DDDBB8458C5" modified="2005-04-12" version="1">MSTIRYLFNEAGTWNKITNFISSNHRSVNSQSTLRNFVKNLGAASSNSQIRSSTEHISSRIESSFSSADRTQSSKFFSGTFSVLSECLVKITDNLADNELPANILTQKTNSIQMFTRKMIVLFLFAGFLGLFPGSFFHNRTPGLDFTGFFSNRRASSNQLSSFLSYFNTMGSKISQKDPMVNEYVIIQRHHRTPIKENMLISSTLGLKQTQIISGFMESHNPGGHVVEAIFANKVYGSATLQNCMNQEEIVMTVVPETLIGRFFLDDLHDEDSVTIRGVMRYSNYKGFGTDKFTFQSIKESEMYMSIPRVYAVVDALSGGSRFREFTLDYALREINKLISALCDDFYGESEERDRNQFVTGYWGGGVFGGDNQYKFILQLIAACVCNRQLVYSDGLNRLDVNQIRQIESKYTTCGQLSDAFFKKHRTNSFSKGNALKVMLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW77</accession>
    <name>Q5CW77_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase (ATP-hydrolyzing)</fullName>
            <ecNumber evidence="4">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd8_1350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the TOP6A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627042.1">
        <property type="nucleotide sequence ID" value="XM_627042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW77"/>
    <dbReference type="STRING" id="353152.Q5CW77"/>
    <dbReference type="GeneID" id="3374512"/>
    <dbReference type="KEGG" id="cpv:cgd8_1350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1350"/>
    <dbReference type="InParanoid" id="Q5CW77"/>
    <dbReference type="OMA" id="GMNILCT"/>
    <dbReference type="OrthoDB" id="5377392at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000228">
        <property type="term" value="C:nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042138">
        <property type="term" value="P:meiotic DNA double-strand break formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000706">
        <property type="term" value="P:meiotic DNA double-strand break processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00223">
        <property type="entry name" value="TOPRIM_TopoIIB_SPO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1360.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002815">
        <property type="entry name" value="Spo11/TopoVI_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013049">
        <property type="entry name" value="Spo11/TopoVI_A_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036078">
        <property type="entry name" value="Spo11/TopoVI_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034136">
        <property type="entry name" value="TOPRIM_Topo6A/Spo11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10848:SF0">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN SPO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21180">
        <property type="entry name" value="TOP6A-Spo11_Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04406">
        <property type="entry name" value="TP6A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01550">
        <property type="entry name" value="TOP6AFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56726">
        <property type="entry name" value="DNA topoisomerase IV, alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52041">
        <property type="entry name" value="TOPO_IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Spo11/DNA topoisomerase VI subunit A N-terminal" evidence="11">
        <location>
            <begin position="56"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="domain" description="Topoisomerase 6 subunit A/Spo11 TOPRIM" evidence="12">
        <location>
            <begin position="178"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="10">
        <location>
            <position position="82"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF21180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK89350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="360" mass="41742" checksum="4F70B2C072A3D5A6" modified="2005-04-12" version="1">MVQEERNLIERGKSKDKLLVLEGEDKRITSRLESSVCSIIRELINGGSRSQIYNSTCLVSVMNILHRNVKEGFHSTLRDIYYNNPSLYTKQSISDKYIAQVTHLVQTPRELLNVVSTARGRIRGPLIIQGYEIGFCERRREVRLDCMSIFESMGHSISPYLFKGMNGLKFSYYSKIKFVLVVEKDTIFQRLLEFGFHKEFDNSCILITARGFSDLPTRTLLYRLSQDLPEDTKFWILCDYDCFGLSIAATYIMGGKSGTWYDSSFSIPKLLPIKVPPVSKLIENELIATYNVFDITQDEISRIINTRNRLMSSNEISQESKSEWNTFCMQMQQDQKRFEIDCIVDIEKWLIKVIRSKLSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW96</accession>
    <name>Q5CW96_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal peptide plus His and thr repeats, signal peptide plus transmembrane domain or GPI anchor, predicted mucin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_1160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627023.1">
        <property type="nucleotide sequence ID" value="XM_627023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW96"/>
    <dbReference type="STRING" id="353152.Q5CW96"/>
    <dbReference type="GeneID" id="3374569"/>
    <dbReference type="KEGG" id="cpv:cgd8_1160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1160"/>
    <dbReference type="InParanoid" id="Q5CW96"/>
    <dbReference type="OMA" id="DTNTHID"/>
    <dbReference type="OrthoDB" id="344164at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254572" evidence="3">
        <location>
            <begin position="24"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="501"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="108"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="158"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="520" mass="56853" checksum="338130BB6A18791A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWD2</accession>
    <name>Q5CWD2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626987.1">
        <property type="nucleotide sequence ID" value="XM_626987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWD2"/>
    <dbReference type="GeneID" id="3374523"/>
    <dbReference type="KEGG" id="cpv:cgd8_770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_770"/>
    <dbReference type="InParanoid" id="Q5CWD2"/>
    <dbReference type="OMA" id="MESNINY"/>
    <dbReference type="OrthoDB" id="341648at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="198"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="283"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="412"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="969"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1195" mass="138401" checksum="3C0146999D11CAFA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWD3</accession>
    <name>Q5CWD3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted secreted protein, 1 or more transmembrane domain, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626986.1">
        <property type="nucleotide sequence ID" value="XM_626986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWD3"/>
    <dbReference type="GeneID" id="3374521"/>
    <dbReference type="KEGG" id="cpv:cgd8_760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_760"/>
    <dbReference type="InParanoid" id="Q5CWD3"/>
    <dbReference type="OMA" id="ANDDIEY"/>
    <dbReference type="OrthoDB" id="339820at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="425" mass="49506" checksum="C702757A96CFCCD9" modified="2005-04-12" version="1">MILSFLTSIKELLVPKGSFGKGPNSKLTEIVALIIISSLLLLGLYWAFIFFFIFLKTGQLTNISTTIAVYSRLEVPSMTICSLPHVSQKDSILDAYLNDRLKVILIYKHANKNYFSFHPKIRKCYWEKQSISNHEQCLCIDMWNQKFFSRRSHAILNPPFFLFQRPTLDGFDVDSISIGIKYLKPVNSTNPHKDSSSEHGFMIKNNTQITNNTRESYSISEILKIGIYDQPMIIANQHAESVEPSWFYSNIGNYAQVSLKLLKNYVFDVEKFYFYIIKGYVSRQENEYEIVVSQKNFNSRMSKVRPERCRMPYWIRIMNNKFYHNSSIRRCIEKSSSSTQEYEVASFTKFQISFRDFSVTEVFRLSGASVIASFLTLTVVCLSAFNKQLIYELLFPYYEDINAKYTVTTIATFFSFGYLKKYSED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWH3</accession>
    <name>Q5CWH3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">CCT-beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_5080</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627831.1">
        <property type="nucleotide sequence ID" value="XM_627831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWH3"/>
    <dbReference type="FunCoup" id="Q5CWH3">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWH3"/>
    <dbReference type="GeneID" id="3375921"/>
    <dbReference type="KEGG" id="cpv:cgd6_5080"/>
    <dbReference type="InParanoid" id="Q5CWH3"/>
    <dbReference type="OMA" id="CAEMVMS"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03336">
        <property type="entry name" value="TCP1_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000002">
        <property type="entry name" value="T-complex protein 1 subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012716">
        <property type="entry name" value="Chap_CCT_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02341">
        <property type="entry name" value="chap_CCT_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00033237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK90176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="536" mass="58718" checksum="797484625A537C9C" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWN2</accession>
    <name>Q5CWN2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="20">DNA polymerase</fullName>
            <ecNumber evidence="20">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">cgd6_4410</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="19 20">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 20">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 20">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 20">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="20"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627772.1">
        <property type="nucleotide sequence ID" value="XM_627772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWN2"/>
    <dbReference type="FunCoup" id="Q5CWN2">
        <property type="interactions" value="427"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWN2"/>
    <dbReference type="GeneID" id="3375782"/>
    <dbReference type="KEGG" id="cpv:cgd6_4410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4410"/>
    <dbReference type="InParanoid" id="Q5CWN2"/>
    <dbReference type="OMA" id="CNNCRPR"/>
    <dbReference type="OrthoDB" id="2414538at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05777">
        <property type="entry name" value="DNA_polB_delta_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05533">
        <property type="entry name" value="POLBc_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000004">
        <property type="entry name" value="DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050240">
        <property type="entry name" value="DNA_pol_type-B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025687">
        <property type="entry name" value="Znf-C4pol"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322">
        <property type="entry name" value="DNA POLYMERASE CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10322:SF23">
        <property type="entry name" value="DNA POLYMERASE DELTA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14260">
        <property type="entry name" value="zf-C4pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 20" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7 20" id="KW-0235">DNA replication</keyword>
    <keyword evidence="17 20" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="14 20" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="13" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="15 20" id="KW-0408">Iron</keyword>
    <keyword evidence="16 20" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="9 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6 20" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="18 20" id="KW-0539">Nucleus</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="12 20" id="KW-0862">Zinc</keyword>
    <keyword evidence="10 20" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="22">
        <location>
            <begin position="210"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="21">
        <location>
            <begin position="528"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="domain" description="C4-type zinc-finger of DNA polymerase delta" evidence="23">
        <location>
            <begin position="991"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00049244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF14260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EAK90037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1084" mass="122667" checksum="826D145F4F25C639" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWN7</accession>
    <name>Q5CWN7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627767.1">
        <property type="nucleotide sequence ID" value="XM_627767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWN7"/>
    <dbReference type="GeneID" id="3375778"/>
    <dbReference type="KEGG" id="cpv:cgd6_4360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4360"/>
    <dbReference type="InParanoid" id="Q5CWN7"/>
    <dbReference type="OMA" id="SAICACC"/>
    <dbReference type="OrthoDB" id="341948at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="235" mass="26316" checksum="A47DA67F3B53E6F6" modified="2007-04-03" version="1">MAKKKGKFDLNIAALSASVGSMVLLMMSIFLSSWLYNAAGKGFYPYPRYWGLLTVIGRRTQSHNEVWEIACITAGKLALGLTCSSPLCIWYSHKCDAYRIVKNISYATAIVLAITCGMLTGAMICSLRSNISSLRLSTAFSFAAFLICSLTLCLYAFLMNEAFGIINSVGYYPVPQPSVSFAIALGGIFLLLVAFIAYAQRYRKLRAEKDFEEDTWYEYQNLKNEYYGYNAMNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWX5</accession>
    <name>Q5CWX5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L32</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_3340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627679.1">
        <property type="nucleotide sequence ID" value="XM_627679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWX5"/>
    <dbReference type="FunCoup" id="Q5CWX5">
        <property type="interactions" value="433"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWX5"/>
    <dbReference type="GeneID" id="3375704"/>
    <dbReference type="KEGG" id="cpv:cgd6_3340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3340"/>
    <dbReference type="InParanoid" id="Q5CWX5"/>
    <dbReference type="OMA" id="HPSGYEE"/>
    <dbReference type="OrthoDB" id="268693at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00513">
        <property type="entry name" value="Ribosomal_L32_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001515">
        <property type="entry name" value="Ribosomal_eL32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018263">
        <property type="entry name" value="Ribosomal_eL32_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036351">
        <property type="entry name" value="Ribosomal_eL32_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23413:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01655">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01393">
        <property type="entry name" value="Ribosomal_L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52042">
        <property type="entry name" value="Ribosomal protein L32e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00580">
        <property type="entry name" value="RIBOSOMAL_L32E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008431"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="137" mass="16140" checksum="B8923BD61B0F95BE" modified="2007-04-03" version="1">MSIVSFKNKPKKAIIKKRTKKFTRFQSDRFLRVKPNWRKPKGIDCRVRRKFKGNYLMPKIGYGSDAKTRKMLPNGLYKFTVSNPQEVHMLLMHNKTFCVEIASGVSSRKRREILERAEQLNLKVLNKNARLAIEEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWY5</accession>
    <name>Q5CWY5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Gpi16p/PIG-T/SPBC1604.15 family glycosyl phosphatidyl inositol 16 signal peptide and transmembrane domain or GPI anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_3240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627669.1">
        <property type="nucleotide sequence ID" value="XM_627669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWY5"/>
    <dbReference type="STRING" id="353152.Q5CWY5"/>
    <dbReference type="GeneID" id="3375695"/>
    <dbReference type="KEGG" id="cpv:cgd6_3240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3240"/>
    <dbReference type="InParanoid" id="Q5CWY5"/>
    <dbReference type="OMA" id="PWFETIN"/>
    <dbReference type="OrthoDB" id="331263at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007245">
        <property type="entry name" value="PIG-T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959:SF11">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12959">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-T-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04113">
        <property type="entry name" value="Gpi16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254327" evidence="2">
        <location>
            <begin position="28"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="552"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="585" mass="67718" checksum="B1A9A9A2315BEB26" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWZ5</accession>
    <name>Q5CWZ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_3130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627659.1">
        <property type="nucleotide sequence ID" value="XM_627659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWZ5"/>
    <dbReference type="GeneID" id="3375892"/>
    <dbReference type="KEGG" id="cpv:cgd6_3130"/>
    <dbReference type="InParanoid" id="Q5CWZ5"/>
    <dbReference type="OMA" id="WSENRIE"/>
    <dbReference type="OrthoDB" id="343729at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="585" mass="66416" checksum="DBC6ACD29314F092" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX00</accession>
    <name>Q5CX00_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627654.1">
        <property type="nucleotide sequence ID" value="XM_627654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX00"/>
    <dbReference type="GeneID" id="3375683"/>
    <dbReference type="KEGG" id="cpv:cgd6_3080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3080"/>
    <dbReference type="InParanoid" id="Q5CX00"/>
    <dbReference type="OMA" id="FSNCASK"/>
    <dbReference type="OrthoDB" id="340003at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="122"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="61"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="650" mass="72484" checksum="46EC1D252B0981D6" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX72</accession>
    <name>Q5CX72_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein with N-terminal apicomplexan-specific globular domain plus PHD domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_2240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627582.1">
        <property type="nucleotide sequence ID" value="XM_627582.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3376174"/>
    <dbReference type="KEGG" id="cpv:cgd6_2240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2240"/>
    <dbReference type="InParanoid" id="Q5CX72"/>
    <dbReference type="OMA" id="KWINERI"/>
    <dbReference type="OrthoDB" id="332390at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20401">
        <property type="entry name" value="Tudor_AtPTM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047365">
        <property type="entry name" value="Tudor_AtPTM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21743">
        <property type="entry name" value="PTM_DIR17_Tudor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="406"/>
            <end position="480"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1476" mass="170294" checksum="BDD325A039F7146B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXA1</accession>
    <name>Q5CXA1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteinase inhibitor I42 chagasin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_1910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627553.1">
        <property type="nucleotide sequence ID" value="XM_627553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXA1"/>
    <dbReference type="MEROPS" id="I42.005"/>
    <dbReference type="GeneID" id="3376066"/>
    <dbReference type="KEGG" id="cpv:cgd6_1910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1910"/>
    <dbReference type="InParanoid" id="Q5CXA1"/>
    <dbReference type="OMA" id="QDHTTEY"/>
    <dbReference type="OrthoDB" id="340510at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004869">
        <property type="term" value="F:cysteine-type endopeptidase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036331">
        <property type="entry name" value="Chagasin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018990">
        <property type="entry name" value="Prot_inh_I42_chagasin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09394">
        <property type="entry name" value="Inhibitor_I42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141066">
        <property type="entry name" value="ICP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0789">Thiol protease inhibitor</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254595" description="Proteinase inhibitor I42 chagasin domain-containing protein" evidence="3">
        <location>
            <begin position="24"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="domain" description="Proteinase inhibitor I42 chagasin" evidence="4">
        <location>
            <begin position="72"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="178" mass="19785" checksum="D64D14846A0F4A00" modified="2007-04-03" version="1">MNKTIFRLLFFFAIYIMIGISNASDMTSSGSLKASNNLEKVKLVNLDLCNSKEAIINVQDISSSDSIIYFITVKPGTEITVNIKGNPTTGYSQQMIIKPNDSIVKVIDAEPSYVPDPHPEGMVGYGGKYTFRFSAVGSGSTVSTIEYARYFERPPKCIFKTEIQFKVIDLPCEEIIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXC3</accession>
    <name>Q5CXC3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_1640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627531.1">
        <property type="nucleotide sequence ID" value="XM_627531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXC3"/>
    <dbReference type="GeneID" id="3376113"/>
    <dbReference type="KEGG" id="cpv:cgd6_1640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1640"/>
    <dbReference type="InParanoid" id="Q5CXC3"/>
    <dbReference type="OMA" id="ETDICRI"/>
    <dbReference type="OrthoDB" id="343092at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="367" mass="42009" checksum="D64E0AD33DDE2333" modified="2007-04-03" version="1">MDWETDKLYIKLSESSNKYGIGPHIIKSFHEYGITRSEENNPTNYLIEGYSQETFYNNLIPHCNLYPKFEYESHLDKIRRIKTSKNLGISLSNKKPSVIIFFVSIDVYDKITSLNKLDIKDYFGHIVIDLLFFQAKKFASIVGTRCVVVWIGIRDCLSQESLFSKEIIELQSDIGAEDNNNRQKQKFIDSSCLDKCITNLLVDYSIDSFEAKNEFEASQYLLSIISGLHEVQKRPISSKYKPKNTSGTNSNPWITQIMQIPGLSDDSARGIENAFKTPKELIRFITDNIARQGLISSKPSLFFESLYGHSSTLDIENSSWFSELANISYFCSKGFCIRKIGKARARKLVILYGNLSFPSKMIGEQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXE7</accession>
    <name>Q5CXE7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627507.1">
        <property type="nucleotide sequence ID" value="XM_627507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXE7"/>
    <dbReference type="GeneID" id="3376009"/>
    <dbReference type="KEGG" id="cpv:cgd6_1360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1360"/>
    <dbReference type="InParanoid" id="Q5CXE7"/>
    <dbReference type="OMA" id="VFTQFIF"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="207" mass="24386" checksum="349A146AF4F805C3" modified="2005-04-12" version="1">MLVFLFESFLINFEDVLSFFEAIFKFVLVVNFATGDFFGLTLFEVGFEVVFFSIFFITLTAEGIELTFDLERAVVFFAGVFLICVFFVSFFVTDCFTLSFAFVIFFIVFLFFIGFSEFIFFIISFFITLFMPEPIIFDLPSTFFAVFFVFKQLFTSELILSVFLLPIFVEHLDLQTILIVLCWTLVKIDKIVYYYTNYLCYNFDCDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXQ6</accession>
    <name>Q5CXQ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_5310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628674.1">
        <property type="nucleotide sequence ID" value="XM_628672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXQ6"/>
    <dbReference type="FunCoup" id="Q5CXQ6">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXQ6"/>
    <dbReference type="GeneID" id="3371756"/>
    <dbReference type="KEGG" id="cpv:cgd7_5310"/>
    <dbReference type="InParanoid" id="Q5CXQ6"/>
    <dbReference type="OMA" id="TCYFCSG"/>
    <dbReference type="OrthoDB" id="10262490at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000001">
        <property type="entry name" value="probable ribosome biogenesis protein RLP24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023442">
        <property type="entry name" value="Ribosomal_eL24_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011017">
        <property type="entry name" value="TRASH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF8">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN RLP24-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00746">
        <property type="entry name" value="TRASH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01073">
        <property type="entry name" value="RIBOSOMAL_L24E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="TRASH" evidence="5">
        <location>
            <begin position="11"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="202" mass="24313" checksum="3D5C32C60AE4B7DC" modified="2005-04-12" version="1" fragment="single">KSTENMRIEKCWYCSSNIYPGHGVTFVRNDAKIFRFCRSKCHRHFKMKHNPRKSKWTKAYRKTRGKEMIMDTTFEFEKKRNCPIRYDRELYIKTIKAMKLVEKIKESRKERFYKTRLMKQQQTQRTLVDKETERNATLLKGPEIPLAQTTTMSDISRQKALKKSEKKMNKIVEKRKSFIDKFSGNTDVSMMDMEDDQEEIVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXV8</accession>
    <name>Q5CXV8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab GDP dissociation inhibitor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628622.1">
        <property type="nucleotide sequence ID" value="XM_628620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXV8"/>
    <dbReference type="STRING" id="353152.Q5CXV8"/>
    <dbReference type="GeneID" id="3372197"/>
    <dbReference type="KEGG" id="cpv:cgd7_4740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4740"/>
    <dbReference type="InParanoid" id="Q5CXV8"/>
    <dbReference type="OrthoDB" id="1923006at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF4">
        <property type="entry name" value="CHM, RAB ESCORT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="587" mass="66982" checksum="9B50BA361D6669FB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY14</accession>
    <name>Q5CY14_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ssm4 ring finger fused to a forkhead associated (FHA) domain (Apicomplexan specific architecture)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_4100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628566.1">
        <property type="nucleotide sequence ID" value="XM_628564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY14"/>
    <dbReference type="STRING" id="353152.Q5CY14"/>
    <dbReference type="GeneID" id="3372069"/>
    <dbReference type="KEGG" id="cpv:cgd7_4100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4100"/>
    <dbReference type="InParanoid" id="Q5CY14"/>
    <dbReference type="OMA" id="WIPNGES"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46210">
        <property type="entry name" value="FHA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46210:SF1">
        <property type="entry name" value="FHA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="348"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="545"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="140"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="726" mass="81693" checksum="F1E424B06C2355C5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY85</accession>
    <name>Q5CY85_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ubiquitin-related modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_3310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">tRNA modification; 5-methoxycarbonylmethyl-2-thiouridine-tRNA biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the URM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628495.1">
        <property type="nucleotide sequence ID" value="XM_628493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY85"/>
    <dbReference type="FunCoup" id="Q5CY85">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY85"/>
    <dbReference type="GeneID" id="3371980"/>
    <dbReference type="KEGG" id="cpv:cgd7_3310"/>
    <dbReference type="InParanoid" id="Q5CY85"/>
    <dbReference type="OMA" id="DYELQPN"/>
    <dbReference type="OrthoDB" id="10248987at2759"/>
    <dbReference type="UniPathway" id="UPA00988"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034227">
        <property type="term" value="P:tRNA thio-modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01764">
        <property type="entry name" value="Ubl_Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03048">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016155">
        <property type="entry name" value="Mopterin_synth/thiamin_S_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015221">
        <property type="entry name" value="Urm1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14986">
        <property type="entry name" value="RURM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09138">
        <property type="entry name" value="Urm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037379">
        <property type="entry name" value="Ubiquitin-related_modifier_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54285">
        <property type="entry name" value="MoaD/ThiS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="98" mass="10872" checksum="754542187B11108E" modified="2005-04-12" version="1" fragment="single">KMSIKVEFSGGLEVLAGDRQNVEVNLNNLKSSSMKSLILYVEENIIQYRKDHFIETGSKIKPGIIVLVNNCDWEILGGENYALSDGDLVTFIMTLHGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYH6</accession>
    <name>Q5CYH6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ORC/CDC6 like AAA ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_2310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628404.1">
        <property type="nucleotide sequence ID" value="XM_628402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYH6"/>
    <dbReference type="STRING" id="353152.Q5CYH6"/>
    <dbReference type="GeneID" id="3372205"/>
    <dbReference type="KEGG" id="cpv:cgd7_2310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2310"/>
    <dbReference type="InParanoid" id="Q5CYH6"/>
    <dbReference type="OMA" id="NIECGIN"/>
    <dbReference type="OrthoDB" id="1926878at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050311">
        <property type="entry name" value="ORC1/CDC6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763:SF26">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10763">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="2">
        <location>
            <begin position="79"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="327"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="551" mass="62436" checksum="A5A0FCA0B7F1B670" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYS0</accession>
    <name>Q5CYS0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_1250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628310.1">
        <property type="nucleotide sequence ID" value="XM_628308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYS0"/>
    <dbReference type="GeneID" id="3371855"/>
    <dbReference type="KEGG" id="cpv:cgd7_1250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1250"/>
    <dbReference type="InParanoid" id="Q5CYS0"/>
    <dbReference type="OrthoDB" id="343752at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="101" mass="11577" checksum="0ED6ECAA612B66E6" modified="2005-04-12" version="1">MIIKCQEKQGNYKYVVTYSSNISRSIKEEDCEENHDSWLMYKSGGSLFTVSKEGSGDWQMRTETGKFESLTETGELKKEPCFSSWWTTYGGVTSKQYVPST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYS8</accession>
    <name>Q5CYS8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein containing ringfinger+4xC2H2+littlefinger domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_1170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628302.1">
        <property type="nucleotide sequence ID" value="XM_628300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYS8"/>
    <dbReference type="STRING" id="353152.Q5CYS8"/>
    <dbReference type="GeneID" id="3371846"/>
    <dbReference type="KEGG" id="cpv:cgd7_1170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1170"/>
    <dbReference type="InParanoid" id="Q5CYS8"/>
    <dbReference type="OMA" id="WTIERIM"/>
    <dbReference type="OrthoDB" id="3838338at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044288">
        <property type="entry name" value="ZNF598/HEL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ZNF598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22938">
        <property type="entry name" value="ZINC FINGER PROTEIN 598"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="55"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="RanBP2-type" evidence="7">
        <location>
            <begin position="1045"/>
            <end position="1074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="307"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="957"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="326"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="338"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="966"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="990"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1006"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1074" mass="122705" checksum="FBFF2933EB0FA7FD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYT1</accession>
    <name>Q5CYT1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein with 2 bromo domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_1130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
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            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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            <end position="294"/>
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        <location>
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            <begin position="74"/>
            <end position="94"/>
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            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
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            <begin position="186"/>
            <end position="196"/>
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        <location>
            <begin position="344"/>
            <end position="367"/>
        </location>
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        <location>
            <begin position="387"/>
            <end position="404"/>
        </location>
    </feature>
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        <location>
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            <end position="859"/>
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        <location>
            <begin position="1182"/>
            <end position="1195"/>
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    </feature>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        </source>
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        </source>
    </evidence>
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        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1352" mass="145351" checksum="D2262260118F1D44" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYU1</accession>
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        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
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                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
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        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
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    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    </dbReference>
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    </dbReference>
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            <end position="5011"/>
        </location>
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        <source>
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        </source>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAK90576.1"/>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYW2</accession>
    <name>Q5CYW2_CRYPI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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            <taxon>Coccidia</taxon>
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            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_628266.1"/>
    </dbReference>
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    <dbReference type="OrthoDB" id="344302at2759"/>
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        <property type="component" value="Chromosome 7"/>
    </dbReference>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="12"/>
            <end position="119"/>
        </location>
    </feature>
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        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="119" mass="13808" checksum="3A2F9D644A36AE02" modified="2005-04-12" version="1" fragment="single">VIFFIKLEMAGDKRKRVQETEVDSEGNEEETSLKKNSVEVDVEEDDFDGLPSEEEELDDIDDEEDDDEEEDDDDDDDDDDDEEGDEQEPTQGGDEDVEDDDDEEEDDEEEEEEDDDDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ00</accession>
    <name>Q5CZ00_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_380</name>
    </gene>
    <organism evidence="1 2">
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        <lineage>
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            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
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            <taxon>Cryptosporidiidae</taxon>
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        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628230.1">
        <property type="nucleotide sequence ID" value="XM_628228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ00"/>
    <dbReference type="GeneID" id="3371906"/>
    <dbReference type="KEGG" id="cpv:cgd7_380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_380"/>
    <dbReference type="InParanoid" id="Q5CZ00"/>
    <dbReference type="OMA" id="CEPSIMI"/>
    <dbReference type="OrthoDB" id="340638at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="579" mass="67378" checksum="5AA3AE75AFBF3882" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPP5</accession>
    <name>A3FPP5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-conjugating enzyme UBC9</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Ubiquitin carrier protein 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_2840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388391.1">
        <property type="nucleotide sequence ID" value="XM_001388354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPP5"/>
    <dbReference type="FunCoup" id="A3FPP5">
        <property type="interactions" value="555"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPP5"/>
    <dbReference type="GeneID" id="3371833"/>
    <dbReference type="KEGG" id="cpv:cgd7_2840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2840"/>
    <dbReference type="InParanoid" id="A3FPP5"/>
    <dbReference type="OMA" id="TWECGIP"/>
    <dbReference type="OrthoDB" id="6600758at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019787">
        <property type="term" value="F:ubiquitin-like protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23798">
        <property type="entry name" value="UBCc_UBE2I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000035">
        <property type="entry name" value="SUMO-conjugating enzyme ubc9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 11" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="12">
        <location>
            <begin position="3"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="10">
        <location>
            <position position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAZ51584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="159" mass="18306" checksum="7E5EA5419C13CADB" modified="2007-04-03" version="1" fragment="single">MSFSRKRIAQERAEWRKDHPVGFSAKYAPSEDGEGQDMMKWICKIPGKSGTLWENGEYTLNVTFPEDYPAKPPKCIFQPPLFHPNIYPSGTVCLSILNEDEDWKPSITMKQILLGIQDLLDNPNIKSPAQAESYQLYSNNRAEYNRRIKQQALQNRPSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPP9</accession>
    <name>A3FPP9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd7_3510</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388395.1">
        <property type="nucleotide sequence ID" value="XM_001388358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPP9"/>
    <dbReference type="STRING" id="353152.A3FPP9"/>
    <dbReference type="GeneID" id="3371837"/>
    <dbReference type="KEGG" id="cpv:cgd7_3510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3510"/>
    <dbReference type="InParanoid" id="A3FPP9"/>
    <dbReference type="OMA" id="QTHQFRD"/>
    <dbReference type="OrthoDB" id="19182at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034085">
        <property type="term" value="P:establishment of sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006139">
        <property type="term" value="P:nucleobase-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF41">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE DDX11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="3"/>
            <end position="340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAZ51588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="775" mass="89639" checksum="C57B57FFD40F109A" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ71</accession>
    <name>A3FQ71_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd2_1820</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388207.1">
        <property type="nucleotide sequence ID" value="XM_001388170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ71"/>
    <dbReference type="STRING" id="353152.A3FQ71"/>
    <dbReference type="GeneID" id="3373449"/>
    <dbReference type="KEGG" id="cpv:cgd2_1820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1820"/>
    <dbReference type="InParanoid" id="A3FQ71"/>
    <dbReference type="OMA" id="YKWLQVF"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045103">
        <property type="entry name" value="RNF5/RNF185-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12313">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="13">
        <location>
            <begin position="42"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="95"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="23"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAZ51380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="200" mass="22625" checksum="68BFCA603BC0B750" modified="2007-04-03" version="1" fragment="single">MGEVNNISNSEIDAKGSGLNGEQSDHHHRSEEKSKNYTSFECNICFENAYEPIVTRCGHLYCWSCICSWLDRGYEDCPVCKAGVNSENVIPLYGRGNENVDPRKKTKPRPKAERPEARQRNQNIGGHNGYFHNADFGFGINNTPLITVFANPLGALLSLGYTHRYFIPEFANSRQSDNSKFSLKYIIIITLLQMKNLEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQJ1</accession>
    <name>A3FQJ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_2710</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388275.1">
        <property type="nucleotide sequence ID" value="XM_001388238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQJ1"/>
    <dbReference type="GeneID" id="3373321"/>
    <dbReference type="KEGG" id="cpv:cgd5_2710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2710"/>
    <dbReference type="InParanoid" id="A3FQJ1"/>
    <dbReference type="OMA" id="ENIEDYT"/>
    <dbReference type="OrthoDB" id="343683at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAZ51297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="240" mass="28071" checksum="CF81A58F7D8A369F" modified="2007-04-03" version="1">MVKKELTENIQNYLACRLCEFDVVVVKKKDAKFHLEEAHSLSINNNIKDEEEIILESMNSQVLERCYSEETLRQLKDDLSDEKQKDFYNESGKDLSIFEATETLKVAILLFLTEFKRKIVALNYPKVYVKNLENEQLNKFLLANQGAYYYYSLIDLANIQDITVQMLLARSWDWSIEDQDLRREIVNIRDGIIANTSHCSHSEALECINTGKLLLLTMHESVKHLLLLCYLTKKVIKRQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQM6</accession>
    <name>A3FQM6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_30</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAZ51232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388044.1">
        <property type="nucleotide sequence ID" value="XM_001388007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQM6"/>
    <dbReference type="GeneID" id="3372634"/>
    <dbReference type="KEGG" id="cpv:cgd4_30"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_30"/>
    <dbReference type="InParanoid" id="A3FQM6"/>
    <dbReference type="OMA" id="NINNIPC"/>
    <dbReference type="OrthoDB" id="342713at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="446" mass="49540" checksum="E660323A10E2AF9B" modified="2007-04-03" version="1">MGGGGSSPEPTTTTTTTTTTTTTTTTTTTTRKTTQSTSTSTETTTSTALVTTTTKAPQSVTGSRFEVPKNKGDDYENGRLSFIFPIHSLKETDLTIEFLNENNITITTFNFKRCCAKIMNSVTGYFDTFEYPSNWESITSMNLTIAWTTAMIYLIISSTLVPLAGIVGYENPSPNSILFKDKNKNEISTAWYFNPDFENILSNSCVITSPGNKCKSGSVKLTMDEPFTPEKQYLRYAFAAPPEYLYPVTITIYSSASFLASIKFSKAMVEISSEKKLNTITIPSPIETGQWIAGDIFLLTSSGYDFLKNNSNNFQCLFITTASCFATQSTQKWRNYDKNLDLLRYAYIKGTEYRTKSSEYIMNSSTDNNFSENTSESEIVYLYVSYNNVIIGGVPIPYSSEITELRITGTKNLVPIAYWRLSQGMTPSITVSTDILKGLIPQIKSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPF8</accession>
    <name>Q5CPF8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625335.1">
        <property type="nucleotide sequence ID" value="XM_625335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPF8"/>
    <dbReference type="GeneID" id="3372336"/>
    <dbReference type="KEGG" id="cpv:cgd3_220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_220"/>
    <dbReference type="InParanoid" id="Q5CPF8"/>
    <dbReference type="OMA" id="AVQSHIH"/>
    <dbReference type="OrthoDB" id="341906at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="165" mass="17182" checksum="C7EAC1920EE9FEC2" modified="2005-04-12" version="1">MSNLSTSTVTQGAQTYNQGTGTQTQTSPNTQTTTSKKTMYPKPQLQQSSISGYEQVSSGVSSPYNGSVGSIPVVLQPPSTSVSPSNYYAVPPAQYILDTSIYSSATPYVAVPATVLSPTVMTSSPQMSAAYASYGFVPSQNLGYTTVGVSPTNTSRPSKYSPGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPF9</accession>
    <name>Q5CPF9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625334.1">
        <property type="nucleotide sequence ID" value="XM_625334.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372337"/>
    <dbReference type="KEGG" id="cpv:cgd3_210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_210"/>
    <dbReference type="InParanoid" id="Q5CPF9"/>
    <dbReference type="OMA" id="HECILEI"/>
    <dbReference type="OrthoDB" id="341165at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1108"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1109"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1192"/>
            <end position="1211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1233"/>
            <end position="1244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1287"/>
            <end position="1306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1937" mass="219295" checksum="F27D1010728D84D5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPG6</accession>
    <name>Q5CPG6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DRG like OBG family GTpase fused to an RNA binding domain TGS domain, Fun11p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625327.1">
        <property type="nucleotide sequence ID" value="XM_625327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPG6"/>
    <dbReference type="FunCoup" id="Q5CPG6">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPG6"/>
    <dbReference type="GeneID" id="3372339"/>
    <dbReference type="KEGG" id="cpv:cgd3_130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_130"/>
    <dbReference type="InParanoid" id="Q5CPG6"/>
    <dbReference type="OMA" id="DVCDQVH"/>
    <dbReference type="OrthoDB" id="1708588at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001436">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="3">
        <location>
            <begin position="63"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="4">
        <location>
            <begin position="288"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="368" mass="41034" checksum="91945245A140964B" modified="2005-04-12" version="1">MGILERIADIEAEMARTQKNKKTEYHLGRLKAQLAKLKTELIEAGSGGKGKGEGFDVAKQGDARVILIGFPSVGKSTLMHELTGTETAVAAYEFTTLTCVPGIMKYNEAKIQLLDLPGIIEGAATGRGRGRQVIAVAHSADLVLMVIDSTKDDSQRRKLEYELEAIGIRLNKKPPQIVVKPKKIGGVTFNSTVPLTHLDNKMVVSILNEYKIYNADVLIKEDCTVDEFIDCIEGNRRYVPCLYVHNKIDNLKLSEIDELARQPNSVVISSQKRWNLDTLVEQIWGKLGLVRLYTKKKGEFPDFSDPLIMTPQRGVINVETAVKLIHKDLINEFKHALVWGTSVKHNPQCVGLSHKLQDEDVIQLVKTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPL4</accession>
    <name>Q5CPL4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide, serine stretches, possible low mw mucin glycoprotein locus of 6 genes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625407.1">
        <property type="nucleotide sequence ID" value="XM_625407.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPL4"/>
    <dbReference type="GeneID" id="3372375"/>
    <dbReference type="KEGG" id="cpv:cgd2_400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_400"/>
    <dbReference type="InParanoid" id="Q5CPL4"/>
    <dbReference type="OrthoDB" id="10403852at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="108"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="194" mass="20990" checksum="06C3E547EC0D8DBF" modified="2005-04-12" version="1">MTFITNYFYAILLILIINSAFFTINEVHPSEYKFSILQIKAPRCPKLRSLLCCCSASSENEDDELQNQNEGAGSGVPVLLAYNPISNTDESNSGGTNGNDEEDPKCCSSSSSSSSSSSSSSKRKKVDVSKSHPSHPGLYTELLTFQPEVGAXSGFTNTATRFPPSDPDPPEFIPNVRTTTTTTTRKTETTSNDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPU8</accession>
    <name>Q5CPU8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RPN2/26s proteasome regulatory subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_3950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the proteasome subunit S1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625416.1">
        <property type="nucleotide sequence ID" value="XM_625416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPU8"/>
    <dbReference type="FunCoup" id="Q5CPU8">
        <property type="interactions" value="542"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPU8"/>
    <dbReference type="GeneID" id="3372421"/>
    <dbReference type="KEGG" id="cpv:cgd4_3950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3950"/>
    <dbReference type="InParanoid" id="Q5CPU8"/>
    <dbReference type="OMA" id="IMFGRQE"/>
    <dbReference type="OrthoDB" id="261572at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016642">
        <property type="entry name" value="26S_Psome_Rpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048570">
        <property type="entry name" value="PSMD1_RPN2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040623">
        <property type="entry name" value="RPN2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF2">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18004">
        <property type="entry name" value="RPN2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21505">
        <property type="entry name" value="RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015947">
        <property type="entry name" value="26S_Psome_Rpn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit 1/RPN2 N-terminal" evidence="7">
        <location>
            <begin position="19"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome regulatory subunit RPN2 C-terminal" evidence="6">
        <location>
            <begin position="823"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="880"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1017"/>
            <end position="1075"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="884"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="949"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1018"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1031"/>
            <end position="1064"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR015947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF21505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1075" mass="120360" checksum="433ED0ECDDA75601" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPV2</accession>
    <name>Q5CPV2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large low complexity protein with repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625527.1">
        <property type="nucleotide sequence ID" value="XM_625527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPV2"/>
    <dbReference type="STRING" id="353152.Q5CPV2"/>
    <dbReference type="GeneID" id="3372466"/>
    <dbReference type="KEGG" id="cpv:cgd8_680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_680"/>
    <dbReference type="InParanoid" id="Q5CPV2"/>
    <dbReference type="OMA" id="MTIRIPN"/>
    <dbReference type="OrthoDB" id="10656665at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125">
        <property type="entry name" value="LP07818P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48125:SF10">
        <property type="entry name" value="OS12G0136300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="725"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="818"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="102"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="557"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="818"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="920"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="1008"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1146" mass="120638" checksum="88D1E41886BFF2A0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPX4</accession>
    <name>Q5CPX4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">60S ribosomal protein L5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_440</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the universal ribosomal protein uL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625505.1">
        <property type="nucleotide sequence ID" value="XM_625505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPX4"/>
    <dbReference type="FunCoup" id="Q5CPX4">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPX4"/>
    <dbReference type="GeneID" id="3372472"/>
    <dbReference type="KEGG" id="cpv:cgd8_440"/>
    <dbReference type="InParanoid" id="Q5CPX4"/>
    <dbReference type="OMA" id="CQIASAH"/>
    <dbReference type="OrthoDB" id="1618453at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008097">
        <property type="term" value="F:5S rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00432">
        <property type="entry name" value="Ribosomal_L18_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.100:FF:000002">
        <property type="entry name" value="60S ribosomal protein L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01337_A">
        <property type="entry name" value="Ribosomal_uL18_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005485">
        <property type="entry name" value="Rbsml_uL18_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057268">
        <property type="entry name" value="Ribosomal_L18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025607">
        <property type="entry name" value="Ribosomal_uL18_C_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410:SF12">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23410">
        <property type="entry name" value="RIBOSOMAL PROTEIN L5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14204">
        <property type="entry name" value="Ribosomal_L18_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17144">
        <property type="entry name" value="Ribosomal_L5e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00058">
        <property type="entry name" value="RIBOSOMALL5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL18 C-terminal eukaryotes" evidence="10">
        <location>
            <begin position="250"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="321" mass="36526" checksum="FB7E81C20643D773" modified="2005-04-12" version="1" fragment="single">AFLLVSYIKNMAFVKVLKNKAYFSRYQVKPRRRREGKTDYQARRAMISQDKTKYNSPKYRFVVRLTNTKVICQIIYATIEGDRVICSADSTELPRYGVPVGLANFSAAYCTGLLCARRVLKQLNMDKIFTGVGEITGDDYHVEEEAEDRRPFKCILDVGLTRTTSGNRVFAAMKGATDGGIYIPHSPNRFPGFTKGENGAEDSFDAEVLKDRILGKHISNYMSEMQEDDPEKYKAHFSQYIKAGITADKLADMYKNAVKAIHADPSRQKKPARKVTKTRVGNTIKTEKSQYVRHVKLTNQQRKERVQKKIELVAQLAAQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPZ5</accession>
    <name>Q5CPZ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625484.1">
        <property type="nucleotide sequence ID" value="XM_625484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPZ5"/>
    <dbReference type="GeneID" id="3372503"/>
    <dbReference type="KEGG" id="cpv:cgd8_200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_200"/>
    <dbReference type="InParanoid" id="Q5CPZ5"/>
    <dbReference type="OMA" id="SHEIMNA"/>
    <dbReference type="OrthoDB" id="339503at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="273"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1130" mass="126614" checksum="7D071368172B78DE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPZ8</accession>
    <name>Q5CPZ8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="16">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="24" type="ORF">cgd8_170</name>
    </gene>
    <organism evidence="24 25">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="24 25" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="25">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 16">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26 16">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Apicoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="24">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="16"/>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625481.1">
        <property type="nucleotide sequence ID" value="XM_625481.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CPZ8">
        <property type="interactions" value="448"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPZ8"/>
    <dbReference type="GeneID" id="3372499"/>
    <dbReference type="KEGG" id="cpv:cgd8_170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_170"/>
    <dbReference type="InParanoid" id="Q5CPZ8"/>
    <dbReference type="OMA" id="LAYCSWC"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020011">
        <property type="term" value="C:apicoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1100.10:FF:000014">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0933">Apicoplast</keyword>
    <keyword evidence="5 16 24" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0934">Plastid</keyword>
    <keyword evidence="25" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="20">
        <location>
            <begin position="122"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="19">
        <location>
            <begin position="271"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="21">
        <location>
            <begin position="568"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="22">
        <location>
            <begin position="690"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="772"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
        <location>
            <begin position="820"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="1199"/>
            <end position="1283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="24">
        <source>
            <dbReference type="EMBL" id="EAK87469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="25">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1287" mass="145127" checksum="77396D1C83C08094" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ57</accession>
    <name>Q5CQ57_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_4050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625569.1">
        <property type="nucleotide sequence ID" value="XM_625569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ57"/>
    <dbReference type="GeneID" id="3372521"/>
    <dbReference type="KEGG" id="cpv:cgd5_4050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4050"/>
    <dbReference type="InParanoid" id="Q5CQ57"/>
    <dbReference type="OMA" id="CIFTNIM"/>
    <dbReference type="OrthoDB" id="339720at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="238" mass="27983" checksum="46146C739621936B" modified="2005-04-12" version="1">MTNELLDSDEINKVWNQSHEDKTTFSVIFSLAQGMFCIVNMIFGYFILFNHFNQLLENRYILKILLFTMFGEIFTSIISAFCMILVRFIFGIRSSTYFLSVISLLSTLLQSVFYYSCFVASVIILHLWYFQINTNPGNFLYNFMINKNTTLDLKHHLLIYFFIEAFISLIEVLTSIPILVSIINYGLTKEIEKIKGKPIVEFYNVNRPITYTNYQNYEKAFENLNNQSSRPEAHYVQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ90</accession>
    <name>Q5CQ90_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">U6 snRNA-associated Sm-like protein LSm1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="primary">LSM1</name>
        <name evidence="7" type="ORF">cgd5_3710</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Probably involved with other LSm subunits in the general process of degradation of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">LSm subunits form a heteromer with a donut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
            <location evidence="4">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625536.1">
        <property type="nucleotide sequence ID" value="XM_625536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ90"/>
    <dbReference type="FunCoup" id="Q5CQ90">
        <property type="interactions" value="53"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ90"/>
    <dbReference type="GeneID" id="3372544"/>
    <dbReference type="KEGG" id="cpv:cgd5_3710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3710"/>
    <dbReference type="InParanoid" id="Q5CQ90"/>
    <dbReference type="OMA" id="EQSMPLW"/>
    <dbReference type="OrthoDB" id="422364at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01728">
        <property type="entry name" value="LSm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034104">
        <property type="entry name" value="Lsm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF8">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="6">
        <location>
            <begin position="44"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="23"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU365047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="160" mass="18527" checksum="74726F9C110F5B82" modified="2005-04-12" version="1">MRDLNYDRTHNEDSSPNQNDEINSNNSNNNNNNNNQTSLSSWMLCLEEDLDKEIYVVLRDGRQFTGIFRSFDQYGSLCLERSFEVFSNNDCYNEIYQGCMIFRGDNLMLCGLIDQNIKSYNAKKIPLADILKIKQEEKNLKSINSNTSPNVFGWIPDDSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQH9</accession>
    <name>Q5CQH9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription initiation factor IID</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="submission" date="2018-09" db="PDB data bank">
            <title>Crystal structure of CGD4-650 with compound BI2536.</title>
            <authorList>
                <consortium name="Structural Genomics Consortium (SGC)"/>
                <person name="Dong A."/>
                <person name="Lin Y.L."/>
                <person name="Hou D."/>
                <person name="Bountra C."/>
                <person name="Arrowsmith C.H."/>
                <person name="Edwards A.M."/>
                <person name="Vedadi M."/>
                <person name="Hui R."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.04 ANGSTROMS) OF 1800-1965</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625669.1">
        <property type="nucleotide sequence ID" value="XM_625669.1"/>
    </dbReference>
    <dbReference type="PDB" id="6MF9">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.04 A"/>
        <property type="chains" value="A/B=1800-1965"/>
    </dbReference>
    <dbReference type="PDBsum" id="6MF9"/>
    <dbReference type="SMR" id="Q5CQH9"/>
    <dbReference type="STRING" id="353152.Q5CQH9"/>
    <dbReference type="GeneID" id="3372750"/>
    <dbReference type="KEGG" id="cpv:cgd4_650"/>
    <dbReference type="InParanoid" id="Q5CQH9"/>
    <dbReference type="OMA" id="YHERRIM"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040240">
        <property type="entry name" value="TAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022591">
        <property type="entry name" value="TAF1_HAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13900:SF0">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12157">
        <property type="entry name" value="DUF3591"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="10" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="7">
        <location>
            <begin position="1864"/>
            <end position="1934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="826"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1272"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1316"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1710"/>
            <end position="1772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="354"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="828"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1274"/>
            <end position="1290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1323"/>
            <end position="1332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1333"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1343"/>
            <end position="1357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1366"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1389"/>
            <end position="1405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1412"/>
            <end position="1425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1441"/>
            <end position="1451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1455"/>
            <end position="1469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1492"/>
            <end position="1501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1530"/>
            <end position="1542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1722"/>
            <end position="1748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1755"/>
            <end position="1772"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="10">
        <source>
            <dbReference type="PDB" id="6MF9"/>
        </source>
    </evidence>
    <sequence length="1965" mass="217607" checksum="BA3FE5F6813D2F7C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQL4</accession>
    <name>Q5CQL4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd4_260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625634.1">
        <property type="nucleotide sequence ID" value="XM_625634.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CQL4"/>
    <dbReference type="FunCoup" id="Q5CQL4">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQL4"/>
    <dbReference type="GeneID" id="3372713"/>
    <dbReference type="KEGG" id="cpv:cgd4_260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_260"/>
    <dbReference type="InParanoid" id="Q5CQL4"/>
    <dbReference type="OMA" id="WLERPCG"/>
    <dbReference type="OrthoDB" id="341484at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007029">
        <property type="term" value="P:endoplasmic reticulum organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040251">
        <property type="entry name" value="SEC31-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923">
        <property type="entry name" value="SEC31-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13923:SF11">
        <property type="entry name" value="SECRETORY 31, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="261"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="545"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="961"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1195"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="961"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1006"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1076"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="1195"/>
            <end position="1208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="10">
        <location>
            <begin position="1214"/>
            <end position="1225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1359" mass="148684" checksum="1F7033DF8EB7D7B1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQM8</accession>
    <name>Q5CQM8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase III subunit RPC3</fullName>
            <shortName evidence="1">RNA polymerase III subunit C3</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625620.1">
        <property type="nucleotide sequence ID" value="XM_625620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQM8"/>
    <dbReference type="STRING" id="353152.Q5CQM8"/>
    <dbReference type="GeneID" id="3372721"/>
    <dbReference type="KEGG" id="cpv:cgd4_110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_110"/>
    <dbReference type="InParanoid" id="Q5CQM8"/>
    <dbReference type="OMA" id="THQVSEN"/>
    <dbReference type="OrthoDB" id="272392at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039748">
        <property type="entry name" value="RPC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12949">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="618" mass="70921" checksum="F5533612EFE4485E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQS1</accession>
    <name>Q5CQS1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Secreted protein with signal peptide and 12 KAZAL repeats and a mucin-like stretch of threonines</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_3550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625931.1">
        <property type="nucleotide sequence ID" value="XM_625931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQS1"/>
    <dbReference type="STRING" id="353152.Q5CQS1"/>
    <dbReference type="GeneID" id="3372855"/>
    <dbReference type="KEGG" id="cpv:cgd4_3550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3550"/>
    <dbReference type="InParanoid" id="Q5CQS1"/>
    <dbReference type="OMA" id="CNGEGNA"/>
    <dbReference type="OrthoDB" id="126772at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF45">
        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254128" evidence="5">
        <location>
            <begin position="26"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="78"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="197"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="267"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="341"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="407"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="486"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="555"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="641"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="790"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="869"/>
            <end position="921"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="6">
        <location>
            <begin position="944"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1012"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1210"/>
            <end position="1229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1012"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1042"/>
            <end position="1055"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1229" mass="136698" checksum="2607BE4C2C0931D0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQW5</accession>
    <name>Q5CQW5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_3030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625887.1">
        <property type="nucleotide sequence ID" value="XM_625887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQW5"/>
    <dbReference type="SMR" id="Q5CQW5"/>
    <dbReference type="ESTHER" id="crypv-q5cqw5">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="3372795"/>
    <dbReference type="KEGG" id="cpv:cgd4_3030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3030"/>
    <dbReference type="InParanoid" id="Q5CQW5"/>
    <dbReference type="OMA" id="WENLINT"/>
    <dbReference type="OrthoDB" id="338904at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254135" description="Phospholipase/carboxylesterase/thioesterase domain-containing protein" evidence="1">
        <location>
            <begin position="21"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="146"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="330" mass="37264" checksum="D747087025429729" modified="2005-04-12" version="1">MGIAVSFLIIFLQLFMSICGRLNLPDDTVEVVGSDYRYLRKISDLRPLRLGTFGHLSRSETPKYTVIFMHGFVVDSSTLYRLTSKFFVRMVRHLDHYDQDYSNNVQLIAPNWHKEFLPFTEEIPNETITTFKAGRPSAEQYILQVLSLIAFINSLVRQGIIPSLENTGIQGNCLGGIIGIAAALGMKSNIGAVATCNSALLHPDLIRRKILRKSAISTSFLLVQGDEDKIIYHKFASVTESILRDWGAKNVLLHKTKGGHFSVMAKHLYTGFRFIASVLLKRQEIFRLEDSYNTKLIAKTKRRVENISEIVPIVPKVTPNDDIQSFNSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQZ1</accession>
    <name>Q5CQZ1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitotic-spindle organizing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd4_2760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MOZART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625861.1">
        <property type="nucleotide sequence ID" value="XM_625861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQZ1"/>
    <dbReference type="SMR" id="Q5CQZ1"/>
    <dbReference type="STRING" id="353152.Q5CQZ1"/>
    <dbReference type="GeneID" id="3372835"/>
    <dbReference type="KEGG" id="cpv:cgd4_2760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2760"/>
    <dbReference type="InParanoid" id="Q5CQZ1"/>
    <dbReference type="OrthoDB" id="48571at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000931">
        <property type="term" value="C:gamma-tubulin ring complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031021">
        <property type="term" value="C:interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033566">
        <property type="term" value="P:gamma-tubulin complex localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051415">
        <property type="term" value="P:microtubule nucleation by interphase microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022214">
        <property type="entry name" value="MZT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28520:SF2">
        <property type="entry name" value="MITOTIC-SPINDLE ORGANIZING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12554">
        <property type="entry name" value="MOZART1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="111" mass="12882" checksum="4EF44B1A3564F15C" modified="2005-04-12" version="1">MIFFSQCAVFLSTMWGNRGIFRITCARIIQFKYFFEINTKIFIIKMRVLSGNAINQEVLETLADISSLLNTGLDKETILILIKLLELGVQPETLSELVIEIRREIESYQIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR19</accession>
    <name>Q5CR19_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C-CAP/cofactor C-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_2450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBCC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625833.1">
        <property type="nucleotide sequence ID" value="XM_625833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR19"/>
    <dbReference type="SMR" id="Q5CR19"/>
    <dbReference type="STRING" id="353152.Q5CR19"/>
    <dbReference type="GeneID" id="3372880"/>
    <dbReference type="KEGG" id="cpv:cgd4_2450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2450"/>
    <dbReference type="InParanoid" id="Q5CR19"/>
    <dbReference type="OMA" id="MEDSEHI"/>
    <dbReference type="OrthoDB" id="194775at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027684">
        <property type="entry name" value="TBCC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012945">
        <property type="entry name" value="Tubulin-bd_cofactor_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139">
        <property type="entry name" value="TUBULIN FOLDING COFACTOR C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15139:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07986">
        <property type="entry name" value="TBCC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="3">
        <location>
            <begin position="16"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="187" mass="21823" checksum="106D6CB19EA2DCE3" modified="2005-04-12" version="1">MELKGNFAVSYFFFLFVKMLIDCIKYIKNKDINYSDKQISRELKLESIYNSKLKLLLGLYKLEISNIEDSSIYFGPVSTSVSIKNCKNCLIAVACRQIRIHDSDGLKIRLSCCTQPLIENCYNITFDIRTKNNVNFYVIFENHLQEMGIHKSEFLTKDNFKVSDLSWLKIQDSPNWKFGNVDLEITE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR44</accession>
    <name>Q5CR44_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_2170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625808.1">
        <property type="nucleotide sequence ID" value="XM_625808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR44"/>
    <dbReference type="GeneID" id="3372954"/>
    <dbReference type="KEGG" id="cpv:cgd4_2170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2170"/>
    <dbReference type="InParanoid" id="Q5CR44"/>
    <dbReference type="OMA" id="TECTISK"/>
    <dbReference type="OrthoDB" id="338232at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="776" mass="90508" checksum="7223E35B83DC5AB8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR61</accession>
    <name>Q5CR61_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein with central transmembrane domain followed by gly-met-pro repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625791.1">
        <property type="nucleotide sequence ID" value="XM_625791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR61"/>
    <dbReference type="GeneID" id="3372967"/>
    <dbReference type="KEGG" id="cpv:cgd4_1970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1970"/>
    <dbReference type="InParanoid" id="Q5CR61"/>
    <dbReference type="OMA" id="LYIFRTY"/>
    <dbReference type="OrthoDB" id="344340at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="224" mass="23082" checksum="E1752AC4CE2BBFCB" modified="2005-04-12" version="1">MRSIGNSKLESFSVTYSGNLHKLSAHSSLFSNSQFESCNTMCDDFDPTCDCNTASTTETEITIDQVESWIEIIKKNAEAAANPILKNDSTSNTTETTDSSNQYVWIGIGVGAIVLIGLIIFFITKSRSNNSQGQDPNANYNMQGGAPGMMPGGMPGMPGMPGMPGGMPGGMPGMPGGMPGMPGMPGMPGMPGMPGMPGMPGGMPGMPGGMPGGMPGMPGGMPMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRA2</accession>
    <name>Q5CRA2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Srp40 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_1540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625750.1">
        <property type="nucleotide sequence ID" value="XM_625750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRA2"/>
    <dbReference type="STRING" id="353152.Q5CRA2"/>
    <dbReference type="GeneID" id="3372932"/>
    <dbReference type="KEGG" id="cpv:cgd4_1540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1540"/>
    <dbReference type="InParanoid" id="Q5CRA2"/>
    <dbReference type="OrthoDB" id="5599646at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039191">
        <property type="entry name" value="Nopp140-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007718">
        <property type="entry name" value="Srp40_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23216:SF1">
        <property type="entry name" value="NUCLEOLAR AND COILED-BODY PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05022">
        <property type="entry name" value="SRP40_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Srp40 C-terminal" evidence="2">
        <location>
            <begin position="164"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="220"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="247" mass="28682" checksum="C3C69C5F95DC8407" modified="2005-04-12" version="1">MTENINKTQVLWLIKNYLCGLEANKAVKYIEKHFPEINELDKKNIKKLKKLPDLHEILKQFYRFNEKKTNLKKSDLDDFSQSNKSIEKITIESQAKDNSNITNKNVTQINTNKKSKKRKSTEILEESNIVDETNPNVNNQIENDENLTSTFNQNSSNCASIQNRFKRIDENKYKEKLSDERLNDNSYWNMKKYSNNSDDFASKAAFELGQVRGKGFRQEKAKKKRCSWKGNGTISTGVSSIQFSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRD9</accession>
    <name>Q5CRD9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SAM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_3190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626247.1">
        <property type="nucleotide sequence ID" value="XM_626247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRD9"/>
    <dbReference type="GeneID" id="3373258"/>
    <dbReference type="KEGG" id="cpv:cgd5_3190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3190"/>
    <dbReference type="InParanoid" id="Q5CRD9"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="34487" checksum="A0C8CB3D1CAEFA59" modified="2005-04-12" version="1">MLLIYSNGDICIETELNSKEKKFELKDHQSYYNILEEVGIVYFREKDQSKFVGKVSKVGRKGKGIMVALDGSMYESEYKAGEFSRGYFLGRYEIPKIDENLFKTKTIINIDRKFNEKRKILGNSRIEKYYDINPELEYFKNNQLHDQEKFDNLLKDLLKNWELDDYFELIHKKLTLDDLLLSSNLLSANGIARALGVNKVGHRIKLSNCIKQFRLVFGPLFLPRQFIKYPTESEITKKSFLPPLFISRPLNLYSYSGINIPFEQLIFVQKLERTDFPCKCSKGGKFFQFKYYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRE0</accession>
    <name>Q5CRE0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser/Thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626246.1">
        <property type="nucleotide sequence ID" value="XM_626246.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373257"/>
    <dbReference type="KEGG" id="cpv:cgd5_3180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3180"/>
    <dbReference type="InParanoid" id="Q5CRE0"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF140">
        <property type="entry name" value="INACTIVE PROTEIN TYROSINE KINASE PTKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="343" mass="38678" checksum="C3B9C4ACE2335A30" modified="2005-04-12" version="1">MYNCVWKDSDSKSIKMNFPPYYYNLKDTINNNSEKVSHDEIKMNPEFTYYIPNLNFNPNFETDFEMNTGSELNNISDLSMSSLNLILSPNSRSQNPSFWPEIPEYNLSFGIHTQSAIKIAKGIATGCLYLKQRGIFHLNLKPTNILIEEDLSVKLADFGHCLLEASFYPNDSIYLDILGNKKVTTNTDSNSSLDFPNLNCSSIENEFSFLNQVSSSPRLSDDRILNYLPPEVLKTNSPLLEPARLYLENKFERCQSIDSYSIGAILWEMINGQPPFGGLGNLQVQAYVGYSGATLDLNPVKDSLLFSNISLIQGLVSRCCGFSKLSHILHFKEIIGLXXXXXX</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRE4</accession>
    <name>Q5CRE4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626242.1">
        <property type="nucleotide sequence ID" value="XM_626242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRE4"/>
    <dbReference type="GeneID" id="3373254"/>
    <dbReference type="KEGG" id="cpv:cgd5_3120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3120"/>
    <dbReference type="InParanoid" id="Q5CRE4"/>
    <dbReference type="OMA" id="CNCKSSE"/>
    <dbReference type="OrthoDB" id="339019at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="394" mass="46151" checksum="66F17D8723A5DE55" modified="2005-04-12" version="1">MYKDEEKESKNSYHGNGESLNSDSYILKSDEIETIRSLIKGKRKELILEENDKNNNQIRPSKMKRKETHKNDLKNGSIEEITKPKIRDYFTCMLFITLKFQDIFTKKNSEIIIGELNFNELFIKFSLNILTEVYKKYYYKAEISSEKPKIYPTFDFQEIKKNPNGQKIYNNICSNSNFDLIVNDTNYQVNQRVGLHLSLTRNHHISKKLSIKFLENIIKKFNNCLDINNEIPEKAFISQRIEIQTKLKSFCILLDYDSVIILKNTYLYSKNTNINGGIFVAIQIHHSSKINYLNPIIEIIDQACIDLGIQPLYSERVFHISLFYIKKSDLYLGNAGHNSKSVIETYNFKEYLSSKLISSSINDFSTLTTKNNIVWINKLVFRVGIYEYYLLLDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRK5</accession>
    <name>Q5CRK5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-dihydrouridine(47) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="2">1.3.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_2440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>5,6-dihydrouridine(47) in tRNA + NAD(+) = uridine(47) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53364"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="3">
            <dbReference type="Rhea" id="RHEA:53366"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>5,6-dihydrouridine(47) in tRNA + NADP(+) = uridine(47) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53360"/>
            <dbReference type="Rhea" id="RHEA-COMP:13539"/>
            <dbReference type="Rhea" id="RHEA-COMP:13540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.89"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="6">
            <dbReference type="Rhea" id="RHEA:53362"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5,6-dihydrouridine in mRNA + NAD(+) = a uridine in mRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69851"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="4">
            <dbReference type="Rhea" id="RHEA:69853"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>a 5,6-dihydrouridine in mRNA + NADP(+) = a uridine in mRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:69855"/>
            <dbReference type="Rhea" id="RHEA-COMP:14658"/>
            <dbReference type="Rhea" id="RHEA-COMP:17789"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="5">
            <dbReference type="Rhea" id="RHEA:69857"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Dus family. Dus3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.89" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626181.1">
        <property type="nucleotide sequence ID" value="XM_626181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRK5"/>
    <dbReference type="STRING" id="353152.Q5CRK5"/>
    <dbReference type="GeneID" id="3373149"/>
    <dbReference type="KEGG" id="cpv:cgd5_2440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2440"/>
    <dbReference type="InParanoid" id="Q5CRK5"/>
    <dbReference type="OMA" id="WSYIAEC"/>
    <dbReference type="OrthoDB" id="259935at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102265">
        <property type="term" value="F:tRNA-dihydrouridine47 synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45846:SF1">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(47) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="7">
        <location>
            <begin position="319"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="7">
        <location>
            <begin position="481"/>
            <end position="619"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="707" mass="80777" checksum="476FA3317BF4CB24" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRU9</accession>
    <name>Q5CRU9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626087.1">
        <property type="nucleotide sequence ID" value="XM_626087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRU9"/>
    <dbReference type="GeneID" id="3373287"/>
    <dbReference type="KEGG" id="cpv:cgd5_1400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1400"/>
    <dbReference type="InParanoid" id="Q5CRU9"/>
    <dbReference type="OrthoDB" id="344062at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="9"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="232" mass="26377" checksum="2AF651CB9EDF3A8D" modified="2005-04-12" version="1">MMKRKFPHNFQTGQIDNIVKNSGTTKARSNYSNVNGNSSPYQYLPKIDRNKSTHCYLNSSSTLPNNLNSKNTKKVENTTKKFSSSLYQKIQNENQSKRPIDSKKEKNESGCSTKINPQQCQEYLNKKEINSSTGQLDERKKIVSSKKSHAEVGKNVSSVEESITVGIKMQLIYSLLCKSEFQSLTQLIFQLLSEKSVGLVNKTDKSKCILFLDYLILRTKKLSYIIDSLIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRZ0</accession>
    <name>Q5CRZ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Csn12p/Rpn3p family protein component of the COP9 signalsome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626046.1">
        <property type="nucleotide sequence ID" value="XM_626046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRZ0"/>
    <dbReference type="FunCoup" id="Q5CRZ0">
        <property type="interactions" value="300"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRZ0"/>
    <dbReference type="GeneID" id="3373130"/>
    <dbReference type="KEGG" id="cpv:cgd5_950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_950"/>
    <dbReference type="InParanoid" id="Q5CRZ0"/>
    <dbReference type="OMA" id="INRMFTL"/>
    <dbReference type="OrthoDB" id="10252687at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045114">
        <property type="entry name" value="Csn12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732:SF0">
        <property type="entry name" value="PCI DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12732">
        <property type="entry name" value="UNCHARACTERIZED PROTEASOME COMPONENT REGION PCI-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="425" mass="49513" checksum="2EF751567F907F55" modified="2005-04-12" version="1">MVSSNEYKNILEWIASVHLSVSNRDGRNLSNLFNLRNFRNTIKGNLCSFYTQDIKLLTQKSFQNKKNLFSGSLSVIIENFLELYKELMKKNCQWANILINGTVILNSWIEIYRDQEAFPCHWVVPVLSSTCILISKIGIMADTMLNSGDLDDDENEDYQNKYQISVLNSIRQQIGKFRGDDDRQAGYVILMTESIKCCMQLRNMQMASTFLKHIESSNINRNRVPKGPMVLFCYFLGKLYMQQDRFVLAEEQLIWAFGNSGKNNKLKRNILECLIPVKFRLGFIPNISLLKKYNLEHYFEISKAILQGNIKRFDAAIEKYSSLFINHGTILCIEKVKFILYRNLMRRIRNWCRKNLKGDPNKLTFSVFDAGFKWQSDELFDQQEMACICANLIKLGYIKGYISWEHQVIVFSVNDPFPKLSNVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS34</accession>
    <name>Q5CS34_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Protein with 4 PHD domains plus a SET domain and associated cysteine cluster at the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd5_400</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626002.1">
        <property type="nucleotide sequence ID" value="XM_626002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS34"/>
    <dbReference type="STRING" id="353152.Q5CS34"/>
    <dbReference type="GeneID" id="3373179"/>
    <dbReference type="KEGG" id="cpv:cgd5_400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_400"/>
    <dbReference type="InParanoid" id="Q5CS34"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059153">
        <property type="entry name" value="NSD_PHD-1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23011">
        <property type="entry name" value="PHD-1st_NSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="8 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="AWS" evidence="17">
        <location>
            <begin position="480"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="15">
        <location>
            <begin position="538"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="16">
        <location>
            <begin position="696"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="14">
        <location>
            <begin position="905"/>
            <end position="965"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAK88172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1004" mass="118494" checksum="DB8BB109B07514FE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS71</accession>
    <name>Q5CS71_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal peptide, possible 4-5x transmembrane domain, SKSR family paralog, telomeric protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_3850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628196.1">
        <property type="nucleotide sequence ID" value="XM_628196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS71"/>
    <dbReference type="STRING" id="353152.Q5CS71"/>
    <dbReference type="GeneID" id="3371506"/>
    <dbReference type="KEGG" id="cpv:cgd1_3850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3850"/>
    <dbReference type="InParanoid" id="Q5CS71"/>
    <dbReference type="OrthoDB" id="344260at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043484">
        <property type="term" value="P:regulation of RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032922">
        <property type="entry name" value="SON"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528:SF1">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254189" evidence="3">
        <location>
            <begin position="29"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="530"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="594"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="711"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="467"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="536"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="602"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="739"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="752"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="924" mass="107462" checksum="6D53211984501E7A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS81</accession>
    <name>Q5CS81_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_3750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628186.1">
        <property type="nucleotide sequence ID" value="XM_628186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS81"/>
    <dbReference type="STRING" id="353152.Q5CS81"/>
    <dbReference type="ESTHER" id="crypv-q5cs81">
        <property type="family name" value="LYsophospholipase_carboxylesterase"/>
    </dbReference>
    <dbReference type="GeneID" id="3371512"/>
    <dbReference type="KEGG" id="cpv:cgd1_3750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3750"/>
    <dbReference type="InParanoid" id="Q5CS81"/>
    <dbReference type="OMA" id="LMFRTYN"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="3">
        <location>
            <begin position="21"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="244" mass="27885" checksum="5D3B824ED8D80013" modified="2005-04-12" version="1">MIQEGDGNNGQGFYYEPKDYDSVLIWLHGKGDNANSYLDFIHIAQNYPELKKTKIILPTADIITFKRFGFSDNAWFDMEDLRPYALEDLDDINNSVSRITRLISLEIEKGIDPKKISLGGFSQGSAIVFLISMASRKYTLGSCIVVGGWLPLTERGFKEGKESKIATEELTFDVRESVKEHVDFIVLHGEADPVVLYQWSLMNKDFVLEFIKPKKFIYKSYPGVVHTITSQMMVDIFNFLSKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSC0</accession>
    <name>Q5CSC0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_3330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628147.1">
        <property type="nucleotide sequence ID" value="XM_628147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSC0"/>
    <dbReference type="GeneID" id="3371452"/>
    <dbReference type="KEGG" id="cpv:cgd1_3330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3330"/>
    <dbReference type="InParanoid" id="Q5CSC0"/>
    <dbReference type="OMA" id="LVECIMI"/>
    <dbReference type="OrthoDB" id="339110at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="188" mass="21510" checksum="881A82EF7CBFEAEC" modified="2005-04-12" version="1">MSNFEESEQIFPTSETKIEAERQQHIILDKKRLITFTLTDICLLLEKVMEQQGDESVITCRSTDWNLIASQLDKDPFEIEYFWKVFNPDIHFKPTLGYAVVPVELNLNQETLLLYENVDHQTNAIYNYKLQSSVNSKMDSLRNQTTLKPILDFAKVRIQLLNSAFEAKKKFNNLACTPASGAGGESGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSE4</accession>
    <name>Q5CSE4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multidomain protein with a conserved eukaryotic domain also present in the human DRIM protein at N-terminus and an archaeal-bacterial domain at C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_3070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628123.1">
        <property type="nucleotide sequence ID" value="XM_628123.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSE4"/>
    <dbReference type="GeneID" id="3371707"/>
    <dbReference type="KEGG" id="cpv:cgd1_3070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3070"/>
    <dbReference type="InParanoid" id="Q5CSE4"/>
    <dbReference type="OMA" id="NIFNMIK"/>
    <dbReference type="OrthoDB" id="360653at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052575">
        <property type="entry name" value="SSU_processome_comp_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046523">
        <property type="entry name" value="UTP20_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17695:SF11">
        <property type="entry name" value="SMALL SUBUNIT PROCESSOME COMPONENT 20 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20416">
        <property type="entry name" value="UTP20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 20" evidence="2">
        <location>
            <begin position="2491"/>
            <end position="2733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2380"/>
            <end position="2431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3469"/>
            <end position="3495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="18"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2387"/>
            <end position="2403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2404"/>
            <end position="2427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="3478"/>
            <end position="3489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF20416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="3779" mass="436129" checksum="FB9BBF5176C4B21B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSF4</accession>
    <name>Q5CSF4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNAJ like chaperone, 4 or more transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_2970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628113.1">
        <property type="nucleotide sequence ID" value="XM_628113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSF4"/>
    <dbReference type="STRING" id="353152.Q5CSF4"/>
    <dbReference type="GeneID" id="3371714"/>
    <dbReference type="KEGG" id="cpv:cgd1_2970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2970"/>
    <dbReference type="InParanoid" id="Q5CSF4"/>
    <dbReference type="OMA" id="TLIYLMR"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="361"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="59"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="271"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="388" mass="44213" checksum="577473E94570D18E" modified="2005-04-12" version="1">MMESILIQGLVGSIIVYMVFSRGKNNLLLFPRLNKFRYIISILLCSSIIAYTIVSKPQTYYDIIQVDRWAPRTELVQAIRIAKKKYHPDKNKLDEKSNYTELFYEIQKIETVFSSETKRNNYNKYGDFRADGNIEDRNIILCLILGAAFHVYSCLFGLFLSFPSIFRKSRGLFPVYSIAVFCAELHMRLSDDPNPLSFLPVIGGLLPFEKIRVLRSLFTCVLIISFVYASNYYRDYDEILNGMLKGNLITNKRIIDLTQSLIVQLQTHGIGSTSTSSGQNKNKKKSNSTSSSNATPLPPKIKVDSDNEQEDPQLEVIQQLSEPLKELASTMNESQKKQLQTVLNIAFTAKGKENKKEGGGFLSRIFGSSFFWIILVGYVFQIIKNYLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSG3</accession>
    <name>Q5CSG3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Syntaxin 5A ortholog, possible transmembrane domain or GPI at C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_2830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628104.1">
        <property type="nucleotide sequence ID" value="XM_628104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSG3"/>
    <dbReference type="FunCoup" id="Q5CSG3">
        <property type="interactions" value="431"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSG3"/>
    <dbReference type="GeneID" id="3371348"/>
    <dbReference type="KEGG" id="cpv:cgd1_2830"/>
    <dbReference type="InParanoid" id="Q5CSG3"/>
    <dbReference type="OMA" id="EHNHNVV"/>
    <dbReference type="OrthoDB" id="421009at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15844">
        <property type="entry name" value="SNARE_syntaxin5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF3">
        <property type="entry name" value="SYNTAXIN-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="309"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="237"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="329" mass="37824" checksum="D9A69388CE6577A4" modified="2005-04-12" version="1" fragment="single">WWKVKMLNSDRTADFFNFVEKHDSTRSEGRIGNSGQSNRYSNSIQGSQFNLLASEISQEMNSTSLKIEELNRIVKQKGLFRDRTNQIHQLTEDIKTSVTELNSRLEVLQQHAQQGFPSSGGYYQSSQHYMTMVETLKARMLDITRDFKDTLQKRTEVIQQQDWRRNLYSYSSNSNNLSGFGSSIGDSKTSFSSGTKYSKMSRVPFDIESGEHGMDQGGTEFEFGAAQSMMQHQNQSFSYARSRAEAVENVQRMIGELAQIFQKVAGMVTQQEEMIQRIDEDISNTFSNVEHGHAELIKYYNYVKSNRGLIIKLFLLLIAFIIFYVIFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSJ4</accession>
    <name>Q5CSJ4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">GDP-fucose protein O-fucosyltransferase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_2440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the glycosyltransferase 68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628073.1">
        <property type="nucleotide sequence ID" value="XM_628073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSJ4"/>
    <dbReference type="FunCoup" id="Q5CSJ4">
        <property type="interactions" value="29"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSJ4"/>
    <dbReference type="GeneID" id="3371703"/>
    <dbReference type="KEGG" id="cpv:cgd1_2440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2440"/>
    <dbReference type="InParanoid" id="Q5CSJ4"/>
    <dbReference type="OMA" id="RNAVWPI"/>
    <dbReference type="OrthoDB" id="422368at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046922">
        <property type="term" value="F:peptide-O-fucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006004">
        <property type="term" value="P:fucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11340">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019378">
        <property type="entry name" value="GDP-Fuc_O-FucTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045130">
        <property type="entry name" value="OFUT2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13398:SF0">
        <property type="entry name" value="GDP-FUCOSE PROTEIN O-FUCOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10250">
        <property type="entry name" value="O-FucT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0294">Fucose metabolism</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254329" description="GDP-fucose protein O-fucosyltransferase 2" evidence="9">
        <location>
            <begin position="29"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026232"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="461" mass="54197" checksum="9A75D3F41961BE80" modified="2005-04-12" version="1">MTNFLYPILLSCILNIRLLFFIFTVANAANNSDQCINILNRWDLRQGMENKCPNWVVDVRWIIYDVKDGEGFNLQRNVFDRMALVVSSLNEIMYKKNEDKFAVLILPPFCNIAHWTYNSKRRLPWSTFFSIKQNGLPTLEYDIYKRLTGIVNIGAEVVGLNFDWNNKSFQSSTSIEYYNSFEISESRHLNSKCFFNNYVRNGNVVYGGRCELVKIRSLICLSFFKLMRFKEVSEEIYKILESNRKEGKLHNYLIKHTEGILVPWPWELSKYRVLDVISYNNNIRRYANLYMSANTFFDEKKPFISVHLRRNDFVFLRNDDIPTFDQVIDRLLQLSNDLKTKRVVISTDSNEYEKNELLDIFLKHNLDLHIINIKDHLDDGIISAVSQVILLNGEYFIGTKESRFSFSVIWDCILSVMNDFKDDISRNFNKCNEVFCGKANEKSSICREHPDRLPKFNIDAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSL3</accession>
    <name>Q5CSL3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_2200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628054.1">
        <property type="nucleotide sequence ID" value="XM_628054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSL3"/>
    <dbReference type="GeneID" id="3371676"/>
    <dbReference type="KEGG" id="cpv:cgd1_2200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2200"/>
    <dbReference type="InParanoid" id="Q5CSL3"/>
    <dbReference type="OMA" id="IDLEWIS"/>
    <dbReference type="OrthoDB" id="340300at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="457" mass="53551" checksum="21F4384014E652E2" modified="2005-04-12" version="1">MDDLKTIVLRQNEILKKLETALSNAIIRIESIERYCNKDNNSVADNLSLILPKETEYGLIKNNSCKSKDLNKEIGNFDFNAVNSAFKLIPIDFLKMDFNNHPINLINNSNVKSSHFIKNLNSNKFVVNSNFYHSAINTDFDHQRLEDLSENMFDNTSTNITSKLPELKTNIKPENQELEIFWEDKENNSNASNNNFKLQTCICENESKSDDKEFFPKETLNFIANKLDMFNMFYNGNKNHILSNCIGKNALNIKSSNKLYIFDEEDNSSMRLDDPLDLEIAENEFYYLKGHIKRSSTRDRPRSSSLDNCHLFNCLYPKTREIKNSCDNIDNLEVYSSNQLTPVDNSYLIREIKYHKPYEKIVGYVQIPYNAFLSRSFESSGHDKIKNKTPLKEVNYLDSRNVHKKIRSPYEERNIFSSNIYQYNRQIAHIKVNCPIFYQFFCFQRYPILILRPLFSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSN2</accession>
    <name>Q5CSN2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">Protein farnesyltransferase subunit beta</fullName>
            <shortName evidence="9">FTase-beta</shortName>
            <ecNumber evidence="2 9">2.5.1.58</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd1_1980</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-cysteinyl-[protein] + (2E,6E)-farnesyl diphosphate = S-(2E,6E)-farnesyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13345"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11535"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:86019"/>
            <dbReference type="ChEBI" id="CHEBI:175763"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="9">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="2 9"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628035.1">
        <property type="nucleotide sequence ID" value="XM_628035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSN2"/>
    <dbReference type="FunCoup" id="Q5CSN2">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSN2"/>
    <dbReference type="GeneID" id="3371655"/>
    <dbReference type="KEGG" id="cpv:cgd1_1980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1980"/>
    <dbReference type="InParanoid" id="Q5CSN2"/>
    <dbReference type="OMA" id="WCIYWIL"/>
    <dbReference type="OrthoDB" id="10261146at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02893">
        <property type="entry name" value="FTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026872">
        <property type="entry name" value="FTB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF6">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 9" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 9 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="10">
        <location>
            <begin position="70"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="497" mass="56781" checksum="8E6516F91502CB5C" modified="2005-04-12" version="1">MNSFDLFLTDFGVYPWYELGMNEYRGGRTFEDWIKSKENSQNCFKNFIESTFHNNFSDYDESANIQDKLLKRNEHLKFVRRMRKTEYPESSIEGESTRILMIYWSIHSEELLTNDSSRLLLDSEDATNNEAFNSKAEEIQLFEDSFDIIATILKFQDESGGFGGNFSHMPNLVSTYLAVSSIIITGDTEALLKIDRFKMYQFFKKLRDFETGGFKIQLDGEVDVRAFYCVSAVASMLQIVTEELFYGIEDYILNCSGFDGGYSGDFGGESHGGYTYCVVSGLCILGKSSIIDIDSLLYWIVQRQSGIEGGFQGRTNKLVDSCYSFWFTGLLFCIEEILRIRTSTTESYIQSCLCDFQALASYILICCQLSEGGLIDKPKKPRDLYHTCYALSGLSLAQRMNSIYRISNKQSPPPFFECQVFDDKYVDKCTSYTPFYSISISEENSINTTDPFLNIRTDKIRKSRLILNRHPLVLTINGCIGTEGIGYKEYIENANAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSP2</accession>
    <name>Q5CSP2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">GCN3p like EIF2B,translation initiation factor eIF-2B alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_1860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628025.1">
        <property type="nucleotide sequence ID" value="XM_628025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSP2"/>
    <dbReference type="FunCoup" id="Q5CSP2">
        <property type="interactions" value="425"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSP2"/>
    <dbReference type="GeneID" id="3371661"/>
    <dbReference type="KEGG" id="cpv:cgd1_1860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1860"/>
    <dbReference type="InParanoid" id="Q5CSP2"/>
    <dbReference type="OMA" id="GDWESCK"/>
    <dbReference type="OrthoDB" id="10249309at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051501">
        <property type="entry name" value="eIF2B_alpha/beta/delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45860:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="376" mass="42394" checksum="C8D69CC549F471EF" modified="2005-04-12" version="1">MELDSIKANDQHCYSNEKNKTGIPILTGRNNVDKVVEYFWEHLKRNLSFEANSRVYKPLISALFSLSRVASESLATNSPELITEITAAKEILMLSLSDEKALYKLVSEFGTTNISIAPICKIFESKILSLVLEGCDSSESQVTFLKNIIIEKTDSFVKNFIFGIQKMVDLSLSIFVKDRMTILTFGYSENVEMVLENAWENFNKHYNLFVVMPSEAKQTNIESEVRKGLYSYQQRKVSEWENGLTKRGINISILSMDTIYNAMNIVDFVLLNIECILENGSAIGICGTAAISCIAKKVFNKPVYIVTHSTKFTNLLPFNMNINNILSDITYQNHQLNSSPVTSIVDISESSYISMIFTDIGAMTPQNVSLETKQYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSP8</accession>
    <name>Q5CSP8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">cgd1_1790</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628019.1">
        <property type="nucleotide sequence ID" value="XM_628019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSP8"/>
    <dbReference type="GeneID" id="3371629"/>
    <dbReference type="KEGG" id="cpv:cgd1_1790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1790"/>
    <dbReference type="InParanoid" id="Q5CSP8"/>
    <dbReference type="OMA" id="ARYILWI"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021319">
        <property type="entry name" value="DUF2921"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF162">
        <property type="entry name" value="TRANSMEMBRANE E3 UBIQUITIN-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11145">
        <property type="entry name" value="DUF2921"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="39"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="296"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="329"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="372"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="408"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="491"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="16">
        <location>
            <begin position="604"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAK88417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="660" mass="75939" checksum="CDF0CA0F0145D687" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CST7</accession>
    <name>Q5CST7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_1380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627980.1">
        <property type="nucleotide sequence ID" value="XM_627980.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CST7"/>
    <dbReference type="FunCoup" id="Q5CST7">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CST7"/>
    <dbReference type="GeneID" id="3371625"/>
    <dbReference type="KEGG" id="cpv:cgd1_1380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1380"/>
    <dbReference type="InParanoid" id="Q5CST7"/>
    <dbReference type="OMA" id="RRFCKWC"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="168"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="206"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="119"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="289"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="306"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="337"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="346" mass="39408" checksum="15053A3FBE8FD3D5" modified="2005-04-12" version="1">MTKSTNMAGTDDILLDHSNGYDKFRRKVLTALPVIFVVVIIMCLYLIYTFYHIIPLIKENSEAGISQVVIFNIFVLMTLVCFVLSILTKPGEIPDTPEWSIKTTGGLQSDLKSKELKSNGERRYCKWCAKYKPDRTHHCRVCRTCVLKMDHHCPWISNCVGWGNHKHLLLLILYSAISCAFITITLGPTLNKSLNMTTIQFGDIVALLLAEILSAFLVVVLFSFFFFHLWLVFNSMTTIEFCEKSRSTSYTNMWFKGYMHSFKQVFGSNPFLWIFPVGNQIGDGINFEHSQKPDRGIQNNEHTNRSNNVSNTNTDVVVDCQPKTTEESSLLLSSKQESGKIRDDSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT05</accession>
    <name>Q5CT05_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted secreted protein, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627912.1">
        <property type="nucleotide sequence ID" value="XM_627912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT05"/>
    <dbReference type="GeneID" id="3371543"/>
    <dbReference type="KEGG" id="cpv:cgd1_570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_570"/>
    <dbReference type="InParanoid" id="Q5CT05"/>
    <dbReference type="OMA" id="ECLEPQW"/>
    <dbReference type="OrthoDB" id="343411at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018624">
        <property type="entry name" value="Sec66"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09802">
        <property type="entry name" value="Sec66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="218"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="234" mass="27509" checksum="1C211F1E0BC87858" modified="2005-04-12" version="1">MWLQILFFIVSCFLLGIIVYYSFKDVEILNSQDEALCDAFISSGRLTFPKKDLKHYFQLRDEVAPQNVGLEEFRLRLRASSPELVSEMKKALLRAAMAVQDNYSRISSEYVGNMQLYKKLLLSEKQWLYVENSMEELKDTVEYIRDEANLIQDSWGDYIFLDARKLNAIRKQQEEMRLQKERLAKEKELEEKKAKEKEKTESNLANKIAQELLEQEESLSNNDSKNNSGNKKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT26</accession>
    <name>Q5CT26_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">AP endonuclease of the TIM barrel fold, possible bacterial horizontal transfer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd1_310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in mitochondrial DNA base excision repair (BER) pathway induced by oxidative stress. Has apurinic/apyrimidinic (AP) endonuclease activity towards double-stranded DNA (dsDNA) with a preference for C as opposite base. Has 3'-phosphatase activity; removes 3'-phosphate from blunt-end, recessed, and gapped DNA templates and thus, removes 3'-blocks for DNA polymerase activity during BER. Lacks 3'-5' exonuclease activity and does not cleave damaged bases by nucleotide incision repair (NIR).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the AP endonuclease 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627891.1">
        <property type="nucleotide sequence ID" value="XM_627891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT26"/>
    <dbReference type="FunCoup" id="Q5CT26">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT26"/>
    <dbReference type="GeneID" id="3371380"/>
    <dbReference type="KEGG" id="cpv:cgd1_310"/>
    <dbReference type="InParanoid" id="Q5CT26"/>
    <dbReference type="OMA" id="HPGSHLR"/>
    <dbReference type="OrthoDB" id="7663182at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00019">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.150:FF:000001">
        <property type="entry name" value="Probable endonuclease 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00152">
        <property type="entry name" value="Nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001719">
        <property type="entry name" value="AP_endonuc_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018246">
        <property type="entry name" value="AP_endonuc_F2_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036237">
        <property type="entry name" value="Xyl_isomerase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013022">
        <property type="entry name" value="Xyl_isomerase-like_TIM-brl"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00587">
        <property type="entry name" value="nfo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002199">
        <property type="entry name" value="PRK01060.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445:SF0">
        <property type="entry name" value="APURINIC-APYRIMIDINIC ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21445">
        <property type="entry name" value="ENDONUCLEASE IV ENDODEOXYRIBONUCLEASE IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01261">
        <property type="entry name" value="AP_endonuc_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00518">
        <property type="entry name" value="AP2Ec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51658">
        <property type="entry name" value="Xylose isomerase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00729">
        <property type="entry name" value="AP_NUCLEASE_F2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00730">
        <property type="entry name" value="AP_NUCLEASE_F2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00731">
        <property type="entry name" value="AP_NUCLEASE_F2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51432">
        <property type="entry name" value="AP_NUCLEASE_F2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Xylose isomerase-like TIM barrel" evidence="12">
        <location>
            <begin position="105"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00054483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="364" mass="41533" checksum="4787C6961B30961A" modified="2005-04-12" version="1" fragment="single">YYPKIYSIECNNWDKMPNSPKKSLKKVIKEEKGEKNQSRNLKQAKLEVFSSNIKTELKVRDDVCHTYEGHKELAEKYRKFVGAHVSASGGVDKSVNNSMNIAGMAFSMFLKPSRGWNAPPLKQQTIDLFKKNCETNKIEYCKFCIPHGSYLINLGNPDEEKRSKMYGAFEDELKRCDALGIKLYNFHPGSTVGQCSKEESIQFISDCINKAHEQTKSVITVLENCAESKCVGYRFKELSEIIERVKDKSRIGVCLDTCHLFAAGYDVRTAESFNKVMVEFEAVIGLKYLKAMHLNDSKGQFNSGLDRHENLGKGNIGMECFKFIMNDSRFNDIPLILETPDPNNDDKVYKKEIAILYDMLVENK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT61</accession>
    <name>Q5CT61_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_4290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626608.1">
        <property type="nucleotide sequence ID" value="XM_626608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT61"/>
    <dbReference type="GeneID" id="3373711"/>
    <dbReference type="KEGG" id="cpv:cgd2_4290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4290"/>
    <dbReference type="InParanoid" id="Q5CT61"/>
    <dbReference type="OrthoDB" id="341887at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="274" mass="31054" checksum="008006554B223354" modified="2005-04-12" version="1">MSSLKDSVVSFQKKDGKMEELESFAKQKSQDVSKVIETKDSNSPQAGAIIRFKSKETIYCSCEFLDLESFYETERDQVESSKITKEVKLISNSNSHLDEYLDTCSKSLISRNSSLSSIESITFMDNNEYKSQINQINTVRNENNVKVCSENEIFNDKLVREFSESSEFTEYHTRSGFLSSLSRRLWDLEETLSFSNLDSISGIKTFLLGKIGHGNIGSKLNTSDHVFLGPKLDDGHAFFANSRGGYESQRSESDTSEESVRYPSFCLDVNEKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT65</accession>
    <name>Q5CT65_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPAC1486.03c-like tuftelin-interacting protein, G-patch domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_4250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFP11/STIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626604.1">
        <property type="nucleotide sequence ID" value="XM_626604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT65"/>
    <dbReference type="STRING" id="353152.Q5CT65"/>
    <dbReference type="GeneID" id="3373479"/>
    <dbReference type="KEGG" id="cpv:cgd2_4250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4250"/>
    <dbReference type="InParanoid" id="Q5CT65"/>
    <dbReference type="OMA" id="WFENEIL"/>
    <dbReference type="OrthoDB" id="4822at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071008">
        <property type="term" value="C:U2-type post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022783">
        <property type="entry name" value="GCFC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045211">
        <property type="entry name" value="TFP11/STIP/Ntr1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329:SF1">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23329">
        <property type="entry name" value="TUFTELIN-INTERACTING PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07842">
        <property type="entry name" value="GCFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="13"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="753" mass="88453" checksum="E93D3F3E498E0CC7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT72</accession>
    <name>Q5CT72_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_4180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626597.1">
        <property type="nucleotide sequence ID" value="XM_626597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT72"/>
    <dbReference type="GeneID" id="3373478"/>
    <dbReference type="KEGG" id="cpv:cgd2_4180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4180"/>
    <dbReference type="InParanoid" id="Q5CT72"/>
    <dbReference type="OMA" id="TPHTIND"/>
    <dbReference type="OrthoDB" id="337532at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="155" mass="16268" checksum="10970192D2304B2F" modified="2005-04-12" version="1">MSDQNIPMPQYASMVAPPSVVLPQSDAAAPSTSILNCCSAPQSTDNGADPALSVNSTPQIGKVRFASTGTTIVTRNGVISFEEFLKKGAPVDQMLIPPFPQVSGIPMFEDGTPDIATIHSTCNVVNLSQTNQTNTIPHSDIGTETSLPQPEDSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT83</accession>
    <name>Q5CT83_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DEXDc+HELICc'DEXDc+HELICc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_4040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626586.1">
        <property type="nucleotide sequence ID" value="XM_626586.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT83"/>
    <dbReference type="GeneID" id="3373490"/>
    <dbReference type="KEGG" id="cpv:cgd2_4040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4040"/>
    <dbReference type="InParanoid" id="Q5CT83"/>
    <dbReference type="OMA" id="INISDLM"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF14">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE (EUROFUNG)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="442"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="6">
        <location>
            <begin position="1219"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1401"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1412"/>
            <end position="1421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1476" mass="172081" checksum="EDF3D5ED456B097A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTB1</accession>
    <name>Q5CTB1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Glutathione S-transferase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_3730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626558.1">
        <property type="nucleotide sequence ID" value="XM_626558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTB1"/>
    <dbReference type="STRING" id="353152.Q5CTB1"/>
    <dbReference type="GeneID" id="3373617"/>
    <dbReference type="KEGG" id="cpv:cgd2_3730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3730"/>
    <dbReference type="InParanoid" id="Q5CTB1"/>
    <dbReference type="OMA" id="NDGPFIG"/>
    <dbReference type="OrthoDB" id="338685at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254500" description="Glutathione S-transferase C-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="domain" description="Glutathione S-transferase C-terminal" evidence="2">
        <location>
            <begin position="150"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="268" mass="29863" checksum="4069EB6B59F920EA" modified="2005-04-12" version="1">MKSISLLASVFAFLALFSTSVESVKAKASIVPITLYSTKELDSNHLVRTVLVYSGLAFTETRFKKDSESQAKLFKEIIKSGFLQPSIPMISDTAKNVQYLSTDEAVLSYIILSYNKELFSKNLLLHTISIQLSSIARSYIKKTTKILDSSKTLTCSKLLTNENIYQTLKVLNDTFASTEHKFLMGNKVSFNDLIAYNLILFIENVSSGCVISNFKGLRELAFNVSSIPQIFKFESSSYFMSLLVPGTHAFAKRINFAHSSAMFLSLAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTG3</accession>
    <name>Q5CTG3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible transmembrane domain near N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626506.1">
        <property type="nucleotide sequence ID" value="XM_626506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTG3"/>
    <dbReference type="GeneID" id="3373561"/>
    <dbReference type="KEGG" id="cpv:cgd2_3120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3120"/>
    <dbReference type="InParanoid" id="Q5CTG3"/>
    <dbReference type="OMA" id="ICTANKK"/>
    <dbReference type="OrthoDB" id="338405at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="592" mass="69473" checksum="9E8CAD4006F6A92B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTG5</accession>
    <name>Q5CTG5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626504.1">
        <property type="nucleotide sequence ID" value="XM_626504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTG5"/>
    <dbReference type="GeneID" id="3373565"/>
    <dbReference type="KEGG" id="cpv:cgd2_3100"/>
    <dbReference type="InParanoid" id="Q5CTG5"/>
    <dbReference type="OMA" id="EHERSNC"/>
    <dbReference type="OrthoDB" id="339729at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="357" mass="41169" checksum="6C97D1FFB654FFE8" modified="2005-04-12" version="1">MIFAISIMNWPYTIYLNRVAKERALTKFKVSLKKENESEKIVNFFKENKTLSMSFLFIATMMFSLHILLSFSVKGILVPVILCYISLPLFVKFVAKANLNEKSDSKITSFLAYLPLYLSSAYIGLKLDDSVNNTFSSNYNSNNILLYGMRLAGDERALRLCISLLFYNFYYLSGFLDTLFQVDTEIERNIYLNNLAPLKVIILIALNALSFPGNKSLVSYIWAYPYYTGGVTTCIFIIGTWVWLELFRITGTQLFKNVKISENLHRHFSRSGIVIYITHSVWLEFVTRYFLIYYISPDSSYSLYDGKSISLFGFVFPGFGMMSSWILLNISGIILSVITYMFIINFRIPRLFFGISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTH0</accession>
    <name>Q5CTH0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_3050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626499.1">
        <property type="nucleotide sequence ID" value="XM_626499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTH0"/>
    <dbReference type="GeneID" id="3373569"/>
    <dbReference type="KEGG" id="cpv:cgd2_3050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3050"/>
    <dbReference type="InParanoid" id="Q5CTH0"/>
    <dbReference type="OrthoDB" id="342526at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="142" mass="15745" checksum="B814277E681DD682" modified="2005-04-12" version="1">MRYNELTTRSTNSTLQELDGIKLKDSESIVDNQRALQITGWMNSFGLPAISSTTMLSQSRFTEGSFMHSSGGQNCSPLLTLIFVRVCNSICNANNDSSSGRASIPIFCLRDCQPFAKFACLRGCRTFGCHVDIYTCMELMCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUB0</accession>
    <name>Q5CUB0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_3540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626904.1">
        <property type="nucleotide sequence ID" value="XM_626904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUB0"/>
    <dbReference type="GeneID" id="3374110"/>
    <dbReference type="KEGG" id="cpv:cgd3_3540"/>
    <dbReference type="InParanoid" id="Q5CUB0"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="101" mass="11816" checksum="3456B05A787AE587" modified="2005-04-12" version="1">MINIDIENKQITMDEGYNTRNALHYAKLLEEFEHRREKKTDISTGKTETNVENVLSMLGQRLRFEEESKIEGSFKLPNKDTIINEFLPLSVNDPVWSDQDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUJ0</accession>
    <name>Q5CUJ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_2640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626824.1">
        <property type="nucleotide sequence ID" value="XM_626824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUJ0"/>
    <dbReference type="STRING" id="353152.Q5CUJ0"/>
    <dbReference type="GeneID" id="3373970"/>
    <dbReference type="KEGG" id="cpv:cgd3_2640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2640"/>
    <dbReference type="InParanoid" id="Q5CUJ0"/>
    <dbReference type="OMA" id="GNCIERI"/>
    <dbReference type="OrthoDB" id="18388at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037379">
        <property type="entry name" value="WDR74/Nsa1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038">
        <property type="entry name" value="NOP SEVEN ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16038:SF4">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 74"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="436" mass="50187" checksum="5B6D3AB372946920" modified="2005-04-12" version="1">MKYLYSSDNFGTIKEYKTTKFLNSDCSFIDSIVEYSNESMKKITYIYAEKKLNSNEESQPKDDMFIGYSDGTINVISIPLKSQSDIPKITFLVNGKVIFIKDITFNYPNESEKGNKVIIVVTESRKLYLFRLPQINKENPYFQSTINFNVCNENACLTNPDLIIETFDLPCNDLKCVAYNKTKNSIAFGGYESDIKMMNLESMKLTWSSKNIQLKMLKNRMPIDVTKLAFLQENPEILLCGTGYGEVRLYAPQLQRRPIINYEIWEEKSSITELEIIKNWAKLKSNRNSYGSVVAIGNNKGSVLLLKITDTQVDIYKRSSFRSESRDSALNKKKILPLIREYVSFKISTDKFKKNKLNNIKSNHKIEISALGNFKGIMGGITTMNSFKLSDKEHKESIFLAIGGPGRYIYIFEVKKRRLVRKIFTSQKIAFIKILE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUM6</accession>
    <name>Q5CUM6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_2200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626788.1">
        <property type="nucleotide sequence ID" value="XM_626788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUM6"/>
    <dbReference type="FunCoup" id="Q5CUM6">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUM6"/>
    <dbReference type="GeneID" id="3374036"/>
    <dbReference type="KEGG" id="cpv:cgd3_2200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2200"/>
    <dbReference type="InParanoid" id="Q5CUM6"/>
    <dbReference type="OMA" id="RVSMYMH"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03751">
        <property type="entry name" value="proteasome_alpha_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000007">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="251" mass="27669" checksum="E40EF365A5EDF7D9" modified="2005-04-12" version="1">MTSVGSGYDSSVSTFSPDGRVFQVEYANKAVDNSGTTIAMIYNSGIVFAVDKYVASKMMVAGTNRRVFAIDNQIGCCVAGFVTDSNKIVSIARSESLNYQKIYGNPIPIRVLAERIAMYMHNFTLYGSVRPFGCSILLGGLDQDRGVELYCIHPSGSCYKYCAMAVGKGRQFARTDLEKLMEKNLSEEDALYEAARVIIQSREEGASKNLELEMAFIGPGSDFQFSIVPEKQINLLNERVEKYIDDLASAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUQ2</accession>
    <name>Q5CUQ2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Snurportin-1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd3_1910</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the snurportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626762.1">
        <property type="nucleotide sequence ID" value="XM_626762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUQ2"/>
    <dbReference type="STRING" id="353152.Q5CUQ2"/>
    <dbReference type="GeneID" id="3374149"/>
    <dbReference type="KEGG" id="cpv:cgd3_1910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1910"/>
    <dbReference type="InParanoid" id="Q5CUQ2"/>
    <dbReference type="OMA" id="IRCILIY"/>
    <dbReference type="OrthoDB" id="10003593at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061015">
        <property type="term" value="P:snRNA import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09232">
        <property type="entry name" value="Snurportin-1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017336">
        <property type="entry name" value="Snurportin-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047857">
        <property type="entry name" value="Snurportin1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403:SF6">
        <property type="entry name" value="SNURPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13403">
        <property type="entry name" value="SNURPORTIN1 RNUT1 PROTEIN RNA, U TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21974">
        <property type="entry name" value="SPN1_m3Gcap_bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Snurportin-1 m3G cap-binding" evidence="10">
        <location>
            <begin position="102"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00016034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="457" mass="53423" checksum="088378351BA300DE" modified="2005-04-12" version="1">MNSSYNSYYKLNHGFIKEKHSDMSSIDKKLRGMLEKLRTERRQKFLKFQRTEDKEYFKPKGKSEKVHSKFIKDWKLSKVWSKELIEYTWLSKLSEGYKSIQENPQDWLLLPICTGSRSMLIQGNGYCELRNQDGWRIFTVKNVPFAHTGLTIIDGIYNQDQNTFYCNDLIVWNNLNICISTTECRLHFLSSRIEESGVTNRTAESMDVSMVLDSNLKLIPNIRIQLGKYFPLSKDSLLHIYGVNDRMHGPLSDFDCLVFVRKDSVYDVEQDYEDAYPECKEYCTASQKNWFIWRDKQNKSFKDCRDKEMDDNTTFKLNINEKNELYTKDKVLIGKVRCSGTLTENLSLDNDQKILLNEFGIVFVKVKFETENILNLLNIISSRCLNSICGNNYSKSENIFELSNVSIQDKFSCKLDSSDYIFFKCIEFITETKYSSCMIPNESNLNLNVESLLNSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUR5</accession>
    <name>Q5CUR5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal peptide containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626749.1">
        <property type="nucleotide sequence ID" value="XM_626749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUR5"/>
    <dbReference type="GeneID" id="3374160"/>
    <dbReference type="KEGG" id="cpv:cgd3_1770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1770"/>
    <dbReference type="InParanoid" id="Q5CUR5"/>
    <dbReference type="OrthoDB" id="344154at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254530" description="Signal peptide containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="186"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="531" mass="59903" checksum="B65B8EA2B36194CB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUS3</accession>
    <name>Q5CUS3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626741.1">
        <property type="nucleotide sequence ID" value="XM_626741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUS3"/>
    <dbReference type="STRING" id="353152.Q5CUS3"/>
    <dbReference type="GeneID" id="3374016"/>
    <dbReference type="KEGG" id="cpv:cgd3_1690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1690"/>
    <dbReference type="InParanoid" id="Q5CUS3"/>
    <dbReference type="OrthoDB" id="343058at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254422" evidence="1">
        <location>
            <begin position="19"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="329" mass="37104" checksum="A6A1F6A940E401BD" modified="2005-04-12" version="1">MCSFLYFILLSVFFVWDASNYSEEYGFSSEIISFIKIKEEHEKEFLVTPLGANSAIIVDAGSGSNDNAVLTVFGDAFSTQFDEIGLSDEEKNEMSRIFSNDCNADVMSYLISVLSTLFVSLKQYECELKLLEKSYRACRGYGGLMRRIKRCNEVEEKYRQNRRGGRETLSQIKKFGEKTIQCATAISRGLWLAGKHTNVENVDSTVECTEQQLLNEQCSLTTYKVFYSVLLSALISVSVSSSKCKEKRKCRKVSRKCKCIFSTADQIEELINELEKKITDKNAFIRSCTKHLINTSGSVNTNQVRAPSEEIDGGLKEITQVSQLLTGTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUU8</accession>
    <name>Q5CUU8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_1410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626716.1">
        <property type="nucleotide sequence ID" value="XM_626716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUU8"/>
    <dbReference type="GeneID" id="3373978"/>
    <dbReference type="KEGG" id="cpv:cgd3_1410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1410"/>
    <dbReference type="InParanoid" id="Q5CUU8"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="110" mass="12304" checksum="C2F5E54BC8D4B63B" modified="2005-04-12" version="1">MCAIIYFTKNLVRDESRESLRCQEVTQLLLSLHRTTANPFPCSVSSLRRYGFHYLTSHLGLHQGNSRDCSLVMGSHRAMLLPGCSDTVSHPKPLTTPLGYSWALSQPVTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUV8</accession>
    <name>Q5CUV8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626706.1">
        <property type="nucleotide sequence ID" value="XM_626706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUV8"/>
    <dbReference type="STRING" id="353152.Q5CUV8"/>
    <dbReference type="GeneID" id="3373987"/>
    <dbReference type="KEGG" id="cpv:cgd3_1310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1310"/>
    <dbReference type="InParanoid" id="Q5CUV8"/>
    <dbReference type="OMA" id="HINEPIS"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14273">
        <property type="entry name" value="UBA_TAP-C_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01767">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF93">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBX" evidence="2">
        <location>
            <begin position="212"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="176"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="306" mass="35729" checksum="D8C91210CEF8A39D" modified="2005-04-12" version="1">MTEISEGQTELLQAFCEITTCDITTGRTILESTNWDLENAISLYYEQQNANVYEGNNFNITEQVNTNNITVNQYENLNEQQETNIDQTNEGKHLNTLKLKKCFKMFLSVCGTSLSAIFGFFKTLFCVPNLNNRAQDNVSIRNFNRSVISQIEQVQIEEARRIREEQDLEYMRSLNLDSMKQEKALEKKRTKDLIRERREKLQAEFQQDRDIEQESLSRVCVKNSAGKKFQRNFHKDDSVYEIFKWIDSLALDKNNLISDKFSLRLPHSKSVEIDDSYADKEITISEIGFYPNTLLLINNFDEDSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUY1</accession>
    <name>Q5CUY1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CNH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_1050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626683.1">
        <property type="nucleotide sequence ID" value="XM_626683.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUY1"/>
    <dbReference type="GeneID" id="3374173"/>
    <dbReference type="KEGG" id="cpv:cgd3_1050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1050"/>
    <dbReference type="InParanoid" id="Q5CUY1"/>
    <dbReference type="OMA" id="PDGTCVH"/>
    <dbReference type="OrthoDB" id="5325112at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034058">
        <property type="term" value="P:endosomal vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001180">
        <property type="entry name" value="CNH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032914">
        <property type="entry name" value="Vam6/VPS39/TRAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019453">
        <property type="entry name" value="VPS39/TGFA1_Znf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894">
        <property type="entry name" value="CNH DOMAIN CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12894:SF27">
        <property type="entry name" value="TRANSFORMING GROWTH FACTOR-BETA RECEPTOR-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10367">
        <property type="entry name" value="zf-Vps39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50219">
        <property type="entry name" value="CNH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="CNH" evidence="6">
        <location>
            <begin position="18"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="247"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="425"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="247"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="426"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1376" mass="157717" checksum="85466C98B8A8F57D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV49</accession>
    <name>Q5CV49_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_5420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627420.1">
        <property type="nucleotide sequence ID" value="XM_627420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV49"/>
    <dbReference type="STRING" id="353152.Q5CV49"/>
    <dbReference type="GeneID" id="3374425"/>
    <dbReference type="KEGG" id="cpv:cgd8_5420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5420"/>
    <dbReference type="InParanoid" id="Q5CV49"/>
    <dbReference type="OrthoDB" id="10505951at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="92"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="287" mass="31131" checksum="9568E53872113BF9" modified="2005-04-12" version="1">MCMLKMLHSNKKMGNNKGLISWLFLSTVTFTVLVLSISYIGNQLSMMARAGGGGGGELVQLNQLADASLLKLRSSSRGSGGAGGRGRNGLSSEDEDEDEDEDEDERRRRIRWEREGLGENCGYFFGKNKDGGKDGKPRGGTPSAPDLSDPPNSGARPKVRSGGSTSPQSSLRRGTGGDPPQSFPHIGGYNADLKTLRQSIQTLRENARKRRGESDGADATPSTSSGFDEDKLGVIFLELLGDPEVTGLYQLFLETAPKEEQKSLEEMITESGLQKEKLLQKLTRYVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV51</accession>
    <name>Q5CV51_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_5400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627418.1">
        <property type="nucleotide sequence ID" value="XM_627418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV51"/>
    <dbReference type="GeneID" id="3374423"/>
    <dbReference type="KEGG" id="cpv:cgd8_5400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5400"/>
    <dbReference type="InParanoid" id="Q5CV51"/>
    <dbReference type="OrthoDB" id="340091at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253886" evidence="1">
        <location>
            <begin position="23"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="276" mass="32164" checksum="DEED77004811B8B4" modified="2005-04-12" version="1">MFFINNKIFISIFSILFTLFSGDDLNSKLGKISMISLRESAHKARGPSVVAENVISEKVPKLFNSISPLELELSENQVDPAILQNSNTSRALNCYQSLPQYILIKGILSEYSYFLNIFYKLKCEHKHEYHDGTKCGDTLFLIDLLENKVEILREKYLNRKNECFIFESNAVSVQSRYFNSDGFIGRSEHTLKDFELLMLERSFLRRVISQFESTLTNKTIEYEISCMKNENSKNNPVDCHLLRTECWLLESELLSLSEEHFKRVSMFKRMDDILDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV79</accession>
    <name>Q5CV79_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_5100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627390.1">
        <property type="nucleotide sequence ID" value="XM_627390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV79"/>
    <dbReference type="GeneID" id="3374230"/>
    <dbReference type="KEGG" id="cpv:cgd8_5100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5100"/>
    <dbReference type="InParanoid" id="Q5CV79"/>
    <dbReference type="OrthoDB" id="341394at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="174" mass="20336" checksum="B039D9B919902924" modified="2005-04-12" version="1">MKCFYVLPLNNSDVFSDLGIRIFESIYERKSWVPKQISLSNIYETDLDSEDFRQNVLNSIIRQISMFNPIRYEGICHFQDTLYRRFSSLWRISEQLGVIFIMVINKETFSLRGKSTLDFVVDWSEKFIQSGKELVANDILIVLHILAPAGQLQLLNDDILSKIELMVNKAIRSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV91</accession>
    <name>Q5CV91_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_4960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627378.1">
        <property type="nucleotide sequence ID" value="XM_627378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV91"/>
    <dbReference type="GeneID" id="3374427"/>
    <dbReference type="KEGG" id="cpv:cgd8_4960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4960"/>
    <dbReference type="InParanoid" id="Q5CV91"/>
    <dbReference type="OrthoDB" id="344242at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254546" evidence="2">
        <location>
            <begin position="17"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="237"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="295"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="309" mass="34765" checksum="8DF987D953920058" modified="2005-04-12" version="1">MNSIISLLILSVVALANISICPTLNTDIQSLNYYVFSYAQINSAAGSTSGSGQSPPNERKRKLSSDEHDSSSSGHRPSRRLRLEDCETSCFSTLDFLKFSLEDISAFHKPEHLTEAQLMELVLTEFENNGVSREDVSSEQILAFVSSQAKICYKKWKTVKQSLKSLEASLIDLEEKQRNSPGTDEDEVRAFSDAYSDIISRQELLTELEASLASVYNNYLLIKEKHTKARRSARIASSRQHSSSHPFSPQTPSTSSSLQSEFSQSQTRLPSAHTTSRSHFRTHQSGRGVTSTRGRSTRMRHRRRRRTLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVB5</accession>
    <name>Q5CVB5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627354.1">
        <property type="nucleotide sequence ID" value="XM_627354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVB5"/>
    <dbReference type="GeneID" id="3374190"/>
    <dbReference type="KEGG" id="cpv:cgd8_4690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4690"/>
    <dbReference type="InParanoid" id="Q5CVB5"/>
    <dbReference type="OMA" id="HANDYEM"/>
    <dbReference type="OrthoDB" id="344019at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1024" mass="121868" checksum="B3705534CC07543C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVC0</accession>
    <name>Q5CVC0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40 repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_4640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627349.1">
        <property type="nucleotide sequence ID" value="XM_627349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVC0"/>
    <dbReference type="STRING" id="353152.Q5CVC0"/>
    <dbReference type="GeneID" id="3374448"/>
    <dbReference type="KEGG" id="cpv:cgd8_4640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4640"/>
    <dbReference type="InParanoid" id="Q5CVC0"/>
    <dbReference type="OMA" id="YSIDIRY"/>
    <dbReference type="OrthoDB" id="340259at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040132">
        <property type="entry name" value="Tex1/THOC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22839">
        <property type="entry name" value="THO COMPLEX SUBUNIT 3 THO3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="413" mass="46313" checksum="2D38CC79F2E099D6" modified="2005-04-12" version="1">MISKVLERRTTAPENVLPTFNQDYSILENCLGHQSVVKITRLHDTKKKSKVCGINWTCDGNKLVYSARDSIQLMNPQLFIAETSIPGQWFKAIPSSLNPFQMICIALNKPCIEFYDLRSGLSHFEITIPNDSFLNVAWSKDDKTVVTGDRADNLYAIDLRFPNSKQLPIPIMKLKNDEENKMNIDSNIVNERQKRRELPYNIQSHKRSSEEINDITFSSDSKHLIMARNDGKLEIIFLENSNDILNQNKSELIQTHLYSSVIVREFSNMIASFGQDQTISLLDLRSKSIISTLGGIDGAATSIEFNNTGEIISTAISSEKKKPGEDSNDTLMLNNTQLKILSRFDVPGRITSSSWHPYRQILAIACNSLESNNANNTSSSNIGTNTSSIHYNKIISSGLNGPNTPFVGFLTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVL7</accession>
    <name>Q5CVL7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627252.1">
        <property type="nucleotide sequence ID" value="XM_627252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVL7"/>
    <dbReference type="GeneID" id="3374305"/>
    <dbReference type="KEGG" id="cpv:cgd8_3590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3590"/>
    <dbReference type="InParanoid" id="Q5CVL7"/>
    <dbReference type="OMA" id="MIASCIN"/>
    <dbReference type="OrthoDB" id="339914at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254463" evidence="2">
        <location>
            <begin position="19"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="501"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="538" mass="60932" checksum="EA4C2DBEB3B66EBD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVX3</accession>
    <name>Q5CVX3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formin homology 2 domain (FH2) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_2450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627146.1">
        <property type="nucleotide sequence ID" value="XM_627146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVX3"/>
    <dbReference type="GeneID" id="3374271"/>
    <dbReference type="KEGG" id="cpv:cgd8_2450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2450"/>
    <dbReference type="InParanoid" id="Q5CVX3"/>
    <dbReference type="OMA" id="DFHIANT"/>
    <dbReference type="OrthoDB" id="1668162at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="498"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="364"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="936"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="377"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="433"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="566"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="940"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1036"/>
            <end position="1054"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1054" mass="116758" checksum="F0CA03C1B75B96F0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW28</accession>
    <name>Q5CW28_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RING finger containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_1870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627091.1">
        <property type="nucleotide sequence ID" value="XM_627091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW28"/>
    <dbReference type="STRING" id="353152.Q5CW28"/>
    <dbReference type="GeneID" id="3374508"/>
    <dbReference type="KEGG" id="cpv:cgd8_1870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1870"/>
    <dbReference type="InParanoid" id="Q5CW28"/>
    <dbReference type="OrthoDB" id="337575at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16531">
        <property type="entry name" value="RING-HC_RING1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044592">
        <property type="entry name" value="RING1A/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46537:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RING1B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46537">
        <property type="entry name" value="OS11G0578200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13923">
        <property type="entry name" value="zf-C3HC4_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="79"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="302" mass="35337" checksum="D8001B4364B5B9FF" modified="2005-04-12" version="1">MDPNPNLGNEDFYEKYPTYHSLVSSIEIPKGLKAFEVVCPKRKLTREGETALNKYELSESILSSVTTLGENDLYSDFNCLICFRILQRTMVVKDCLHRFCGECIEKCVRIGLRECPQCRLHIASRRSLRNDSIMDTLTLRLFPEASEFERRHQEILISNNIKQFKNIMDYQKEPDSKVKDQEPVFEAENTKDFEIIGVLLKPIEGNIEQFRLKSNLFTFNLRLPIHVKITYLRQFILGKLRKERPSSKLEVQFQSVENCQNQKKILELFNKDVSIGELAKDEQGKQEYKDIISILFKIIRTD</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW91</accession>
    <name>ADT_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ADP/ATP translocase</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">ADP,ATP carrier protein</fullName>
            <shortName evidence="9">CpAAC</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_1210</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="10" key="2">
        <citation type="journal article" date="2020" name="Int. J. Mol. Sci." volume="21" first="0" last="0">
            <title>A Single Cysteine Residue in the Translocation Pathway of the Mitosomal ADP/ATP Carrier from Cryptosporidium parvum Confers a Broad Nucleotide Specificity.</title>
            <authorList>
                <person name="King M.S."/>
                <person name="Tavoulari S."/>
                <person name="Mavridou V."/>
                <person name="King A.C."/>
                <person name="Mifsud J."/>
                <person name="Kunji E.R.S."/>
            </authorList>
            <dbReference type="PubMed" id="33255957"/>
            <dbReference type="DOI" id="10.3390/ijms21238971"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TRANSPORTER ACTIVITY</scope>
        <scope>ACTIVITY REGULATION</scope>
    </reference>
    <comment type="function">
        <text evidence="1 8">ADP:ATP antiporter that mediates import of ADP into the mitosome for ATP synthesis, and export of ATP out to fuel the cell (PubMed:33255957). Has broad nucleotide specificity and can also transport TDP, TTP, UDP and UTP (PubMed:33255957). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ADP(in) + ATP(out) = ADP(out) + ATP(in)</text>
            <dbReference type="Rhea" id="RHEA:34999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:35000"/>
        </physiologicalReaction>
    </comment>
    <comment type="activity regulation">
        <text evidence="8">Inhibited by carboxyatractyloside acid (CATR) and bongkrekic acid (BKA).</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitosome inner membrane</location>
            <topology evidence="4">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="sequence caution" evidence="10">
        <conflict type="erroneous initiation">
            <sequence resource="EMBL-CDS" id="EAK89674" version="1"/>
        </conflict>
        <text>Extended N-terminus.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89674.1"/>
        <property type="status" value="ALT_INIT"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627028.1">
        <property type="nucleotide sequence ID" value="XM_627028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW91"/>
    <dbReference type="SMR" id="Q5CW91"/>
    <dbReference type="FunCoup" id="Q5CW91">
        <property type="interactions" value="97"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW91"/>
    <dbReference type="EnsemblProtists" id="EAK89674">
        <property type="protein sequence ID" value="EAK89674"/>
        <property type="gene ID" value="cgd8_1210"/>
    </dbReference>
    <dbReference type="GeneID" id="3374639"/>
    <dbReference type="KEGG" id="cpv:cgd8_1210"/>
    <dbReference type="InParanoid" id="Q5CW91"/>
    <dbReference type="OMA" id="CWATIYK"/>
    <dbReference type="OrthoDB" id="270584at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005471">
        <property type="term" value="F:ATP:ADP antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140021">
        <property type="term" value="P:mitochondrial ADP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990544">
        <property type="term" value="P:mitochondrial ATP transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000061">
        <property type="entry name" value="ADP/ATP transporter on adenylate translocase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002113">
        <property type="entry name" value="ADT_euk_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635">
        <property type="entry name" value="ADP,ATP CARRIER PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45635:SF14">
        <property type="entry name" value="ADP_ATP TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00927">
        <property type="entry name" value="ADPTRNSLCASE"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0050">Antiport</keyword>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-1025">Mitosome</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0677">Repeat</keyword>
    <keyword id="KW-0812">Transmembrane</keyword>
    <keyword id="KW-1133">Transmembrane helix</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000463080" description="ADP/ATP translocase">
        <location>
            <begin position="1"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=1" evidence="1">
        <location>
            <begin position="16"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=2" evidence="1">
        <location>
            <begin position="84"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=3" evidence="1">
        <location>
            <begin position="119"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=4" evidence="1">
        <location>
            <begin position="185"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=5" evidence="1">
        <location>
            <begin position="217"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical; Name=6" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="15"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="121"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="5">
        <location>
            <begin position="218"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Important for transport activity" evidence="3">
        <location>
            <begin position="245"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Nucleotide carrier signature motif" evidence="2">
        <location>
            <begin position="245"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for conferring broad nucleotide specificity" evidence="8">
        <location>
            <position position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="G2QNH0"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="2">
        <source>
            <dbReference type="UniProtKB" id="P02722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000250" key="3">
        <source>
            <dbReference type="UniProtKB" id="P12235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="4"/>
    <evidence type="ECO:0000255" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="7">
        <source>
            <dbReference type="RuleBase" id="RU368008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="8">
        <source>
            <dbReference type="PubMed" id="33255957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="9">
        <source>
            <dbReference type="PubMed" id="33255957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="10"/>
    <evidence type="ECO:0000312" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000312" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK89674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="310" mass="35088" checksum="C2EAE96B598508D4" modified="2026-01-28" version="2">MENKKEEKQNKKKKNNFLTDFIVGGISATISKTAVAPIERVKLLLQTQDTNPDIIKGLIPRYAGIFDCLRRVSKEQGILSLWRGNTTNVIRYFPTQAFGFAFKDMIRDMMPRYNKESDFWKFFGVNMLSGGLAGAASSGIVYPLDFARTRLATDIGKNGSKEFKGMFDCIMKISKQSGIRSLYQGFFVSIQGIFVYRAAYFGLYDTTKEMFFKNQKQENMLYKWIIAQTVTTSAGIICYPFDTIRRRMMMMAGKKGKDVLYTGAYDCLKKIIRKEGVGALFKGSLSNVLRGTGGALVLILYDEIKKALEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWE9</accession>
    <name>Q5CWE9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_5370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627855.1">
        <property type="nucleotide sequence ID" value="XM_627855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWE9"/>
    <dbReference type="GeneID" id="3375850"/>
    <dbReference type="KEGG" id="cpv:cgd6_5370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5370"/>
    <dbReference type="InParanoid" id="Q5CWE9"/>
    <dbReference type="OrthoDB" id="341058at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="345" mass="40216" checksum="D3A29C4C37F9DAF7" modified="2005-04-12" version="1">MYGTNFNDLQGVYSMVSPLQSFRTPRLENQNHNNFFPENKNYLQINTERLIHSSKNFIDDSKILTYRSGSFIQANSQGYKPNETLQSTNYSDNTTVSESQLSSNQFFESENDSFISQNVKPSKNLVNNATNTLDNKSENELKQLIDDPKDLSSTKIENKTDNRIELDLKIPKNISLEEICETEQFDYFPQLINEVNEKIDMEEIEYNTEDINHNFDKESIISSSDTQGCMEICITPPLSSELITSNNFYFPEDNKEESQNGSILRTNKDFCEEFTDIETHKNDILENQNILRENGKRKFRFSSLCPKLLNCLFPWIRSEQYFEDHDQPIFYITSNNEESQKLTNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWH2</accession>
    <name>Q5CWH2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_5090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627832.1">
        <property type="nucleotide sequence ID" value="XM_627832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWH2"/>
    <dbReference type="STRING" id="353152.Q5CWH2"/>
    <dbReference type="GeneID" id="3375828"/>
    <dbReference type="KEGG" id="cpv:cgd6_5090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5090"/>
    <dbReference type="InParanoid" id="Q5CWH2"/>
    <dbReference type="OMA" id="ILIWANP"/>
    <dbReference type="OrthoDB" id="27237at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010770">
        <property type="entry name" value="Ecd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060:SF0">
        <property type="entry name" value="PROTEIN ECDYSONELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13060">
        <property type="entry name" value="SGT1 PROTEIN HSGT1 SUPPRESSOR OF GCR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07093">
        <property type="entry name" value="SGT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="573" mass="67295" checksum="94B83C06ACB2A90D" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWN4</accession>
    <name>Q5CWN4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627770.1">
        <property type="nucleotide sequence ID" value="XM_627770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWN4"/>
    <dbReference type="GeneID" id="3375781"/>
    <dbReference type="KEGG" id="cpv:cgd6_4390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4390"/>
    <dbReference type="InParanoid" id="Q5CWN4"/>
    <dbReference type="OMA" id="YTHNATS"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="577"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="577" mass="65397" checksum="0BE29A5F979869CA" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWN5</accession>
    <name>Q5CWN5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphatase subunit protein g4-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_4380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627769.1">
        <property type="nucleotide sequence ID" value="XM_627769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWN5"/>
    <dbReference type="STRING" id="353152.Q5CWN5"/>
    <dbReference type="GeneID" id="3375780"/>
    <dbReference type="KEGG" id="cpv:cgd6_4380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4380"/>
    <dbReference type="InParanoid" id="Q5CWN5"/>
    <dbReference type="OMA" id="HKFWAYE"/>
    <dbReference type="OrthoDB" id="10265007at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030865">
        <property type="term" value="P:cortical cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039865">
        <property type="entry name" value="PPP2R3C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12085:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B'' SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="466"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="476"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="496" mass="58315" checksum="AD858E7A9C6CBA3C" modified="2007-04-03" version="1">MNHVTAFLERMDDLSRKNYIERNGKGKLFDLLRKTATQISLKNQLFYTEYKTGKTLTFFEELNRSFPIICLLLFERRVRSKSDGIVVRYKEFRRCRDHCPEIFSQFLTPSMYAKMFKDCYGFISPTKFINTCLKILYTFQIRSELGYINPMEEVITYYDFLYWIKNSIRENSETKLGLVRQFSINHPNFENFYANYVIERIIFFSGSKNSIIRIQDLISSDQFARFLELRLADTSESENPFNPQLIFQIFEWFEYRTKSINTEQNGQFTNEDSEDQNQNLSVGNFEDKLFLPEMLQQLLMDFEYIIPIFVIYRIFEVHSENCKSITDSNGQTRTAIGIKTVFKVLFSLEFRESPQSINWFWNILDLNETGYIDQSVISCFWKSMVASIEQIYSIESLPLFEHISDEIFDMICPGELNGKIYKKAFKDSPMASTVISYLCDPKAFIAIEMREEIIAQNASRNLEDNQTSLDLEKPSYNDSESNSDTIDCSQESISVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWQ5</accession>
    <name>Q5CWQ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">EF-hands domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627749.1">
        <property type="nucleotide sequence ID" value="XM_627749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWQ5"/>
    <dbReference type="STRING" id="353152.Q5CWQ5"/>
    <dbReference type="GeneID" id="3375764"/>
    <dbReference type="KEGG" id="cpv:cgd6_4160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4160"/>
    <dbReference type="InParanoid" id="Q5CWQ5"/>
    <dbReference type="OMA" id="SAETWIT"/>
    <dbReference type="OrthoDB" id="435273at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049007">
        <property type="entry name" value="MTIP_EFh"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21550">
        <property type="entry name" value="MTIP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="147"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="362" mass="40384" checksum="AE867FACB3B9E713" modified="2007-04-03" version="1">MISLLNGTGCVSCTSGCKVVIDDYKTTGRIEYGVFVGYYSESEESDYDESDVVTLDKKPSNIQDSSSAEAVSIEDELEEGEADIIREMFDNASSGGECSLDQTCHLAHRMGLAPSKSDLEQLNEETGGKVTYEDFERWIMSITHPEDHIDYMVSYFRKYDLRGNGKISRQQFIWLTSIGGDILTREEAEAILDKLSIGGDVYYEDLLRKIMDVEASDKPMVNIGNKKSTPTKMPTTKVLVTQVSTTIRDLADNEAFLPTIDLLMALKATYGNELTEAAAKEATDCCENQDEAAKCLQEFYSEWAQNKGMVSRKIVRSLLMVWKAKLDQVSAEAWITSLCGTDENIDIQSVLNKVECKTNEIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWV1</accession>
    <name>Q5CWV1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sf-assemblin Low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_3620</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF-assemblin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627703.1">
        <property type="nucleotide sequence ID" value="XM_627703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWV1"/>
    <dbReference type="STRING" id="353152.Q5CWV1"/>
    <dbReference type="GeneID" id="3375724"/>
    <dbReference type="KEGG" id="cpv:cgd6_3620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3620"/>
    <dbReference type="InParanoid" id="Q5CWV1"/>
    <dbReference type="OMA" id="QNYCDEQ"/>
    <dbReference type="OrthoDB" id="436841at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008374">
        <property type="entry name" value="SF_assemblin/giardin_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40412">
        <property type="entry name" value="SF-ASSEMBLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR40412:SF1">
        <property type="entry name" value="SF-ASSEMBLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06705">
        <property type="entry name" value="SF-assemblin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01799">
        <property type="entry name" value="SFASSEMBLIN"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="164"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="396" mass="44575" checksum="34B2E0E2729DD402" modified="2007-04-03" version="1">MLKEEIMDLINKSSLTISTGGIVAPVNEIKTNLDITTNLDEVVVGNENLNLSGFNSQTGGTSQSPKHLQLSLSSRNIKQNQTNLKNSLGRKNGSLSALFSQQLGGTISNLNSTNNTSIATTSLSPITVAETSTSGLIHSPTSLIGNSSLPLSTKQKLGQIQGQLLGLEKQLRNDTRQKREYEENRLQVLKENTMKLKKAIEAENQQRNEIQSNMKRNFEEQMSSIQQRLEDVFSGKLDQLSIACKSLDERLSVIEKEMVSEKSQIIEEFEHKHQSLVNEIMNAKSIAEREYNIAEEKEEQMKLFLKELENHVEEEIGREVNNKEMVLSSINDSFNQLKDKIEKTQDKFQNFVLEEIAHIKNDIAKESQNREAADDDIVQALNQYTKALQDVLKIIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX73</accession>
    <name>Q5CX73_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">2-(3-amino-3-carboxypropyl)histidine synthase subunit 1</fullName>
            <ecNumber evidence="3 11">2.5.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_2230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36783"/>
            <dbReference type="Rhea" id="RHEA-COMP:9748"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:29979"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="EC" id="2.5.1.108"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="11">Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the DPH1/DPH2 family. DPH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.108" evidence="3 11"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627581.1">
        <property type="nucleotide sequence ID" value="XM_627581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX73"/>
    <dbReference type="FunCoup" id="Q5CX73">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX73"/>
    <dbReference type="GeneID" id="3376173"/>
    <dbReference type="KEGG" id="cpv:cgd6_2230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2230"/>
    <dbReference type="InParanoid" id="Q5CX73"/>
    <dbReference type="OMA" id="PGQVLGC"/>
    <dbReference type="OrthoDB" id="1649088at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11850">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11860">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042264">
        <property type="entry name" value="DPH1/DPH2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042265">
        <property type="entry name" value="DPH1/DPH2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035435">
        <property type="entry name" value="DPH1/DPH2_euk_archaea"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF1">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004967">
        <property type="entry name" value="DPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00021915"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR004967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="497" mass="56630" checksum="976B5BD58E692FFC" modified="2007-04-03" version="1">MDSTIANPNISLSNDINYKRFDPGYSDIENIELLKEAIRVGLPSHYDFEIIKTIKKINEIKSISDERENFTVYLQMPEGLLVFSQSISLILQHFARTSVVILGDITYGGCCIEDQLMSILESSHSKSSNQSLLVHYAHSCLIPFEELAMSKDINIANILYIFVEINLLSDHFIQTIKHNFKKEDKIALLSTIQYHSTIVGSQKCLNDYFLNPVKIPVCDPLAWGETLGCTSAIIDGDVEKCIFLSDGRFHLESAMIQNPSKVFYLYEPFSKKITRETYSHQLLHEIRKSSIVNSFKIVQAGGSNLINDSVVIGIFFSTLGRQGSFAIVERLEKLINKYNTNTNNKTKIVACTIFASDLSAECINDNILEGVDYSIQLACPRLSTDWGAYYKKPILNSYEAFVLLGNLSNNNFQFFCDMENNLDLSNSEFSYLQTYPMNYWASNGNIWCNYYSDESRNGSFGASKDQIDEIKYNIRQNKLKNLTKRKINLQYERNELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXG6</accession>
    <name>Q5CXG6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627488.1">
        <property type="nucleotide sequence ID" value="XM_627488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXG6"/>
    <dbReference type="GeneID" id="3376032"/>
    <dbReference type="KEGG" id="cpv:cgd6_1160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1160"/>
    <dbReference type="InParanoid" id="Q5CXG6"/>
    <dbReference type="OMA" id="CANMINS"/>
    <dbReference type="OrthoDB" id="340685at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="681"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="682"/>
            <end position="695"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="708" mass="78460" checksum="BDE58E1B39AC5967" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXI1</accession>
    <name>Q5CXI1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PP2C like protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_1010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627473.1">
        <property type="nucleotide sequence ID" value="XM_627473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXI1"/>
    <dbReference type="GeneID" id="3376096"/>
    <dbReference type="KEGG" id="cpv:cgd6_1010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1010"/>
    <dbReference type="InParanoid" id="Q5CXI1"/>
    <dbReference type="OMA" id="WITHTIG"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="107"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="287"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="715" mass="79261" checksum="3D07E3A92DD94E57" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXJ5</accession>
    <name>Q5CXJ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Thioredoxin protein disulfide isomerase A6, signal peptide, possible transmembrane domain in C-terminal region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Probable disulfide isomerase, which participates in the folding of proteins containing disulfide bonds. May act as a dithiol oxidase. Acts as a regulator of endoplasmic reticulum-mitochondria contact sites via its ability to regulate redox signals.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627459.1">
        <property type="nucleotide sequence ID" value="XM_627459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXJ5"/>
    <dbReference type="SMR" id="Q5CXJ5"/>
    <dbReference type="STRING" id="353152.Q5CXJ5"/>
    <dbReference type="GeneID" id="3375864"/>
    <dbReference type="KEGG" id="cpv:cgd6_850"/>
    <dbReference type="InParanoid" id="Q5CXJ5"/>
    <dbReference type="OMA" id="WIHAIAV"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052250">
        <property type="entry name" value="PDI_TMX3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46426:SF1">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE TMX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2 7 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254608" evidence="8">
        <location>
            <begin position="29"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="13"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="482"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="483"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00045246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="524" mass="60945" checksum="C5B5D3F9142C6FAA" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXQ1</accession>
    <name>Q5CXQ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_5360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628679.1">
        <property type="nucleotide sequence ID" value="XM_628677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXQ1"/>
    <dbReference type="GeneID" id="3372145"/>
    <dbReference type="KEGG" id="cpv:cgd7_5360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5360"/>
    <dbReference type="InParanoid" id="Q5CXQ1"/>
    <dbReference type="OMA" id="KHIINEM"/>
    <dbReference type="OrthoDB" id="361918at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="598"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="619"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="657" mass="74693" checksum="B9427437E6E63FDD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXX4</accession>
    <name>Q5CXX4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DID domain proteins (DID4/DID2 family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628606.1">
        <property type="nucleotide sequence ID" value="XM_628604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXX4"/>
    <dbReference type="FunCoup" id="Q5CXX4">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXX4"/>
    <dbReference type="GeneID" id="3372184"/>
    <dbReference type="KEGG" id="cpv:cgd7_4570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4570"/>
    <dbReference type="InParanoid" id="Q5CXX4"/>
    <dbReference type="OMA" id="KMAKMNQ"/>
    <dbReference type="OrthoDB" id="2329734at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10476">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="191"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="226" mass="25415" checksum="7EE54169E5463C50" modified="2005-04-12" version="1">MGIWGSKVDIKDEVNKNKRAVSKAIREVDREIQKLEQEEAKLMRELRIAVEKGYTESAKIFSRDILKLRKQMERLSLARSQLMGAELRLTSVKSQLQVNSAISDLNSIMGRVNDSTEISRIQGILKNFARESDKMDVKGEIINDSIDVAMGNESQPEEEEALVNKIYMEVCESVRQGKEKELAKANAKGPNINNLLSYSSSNKDNPGDEGSGISIEERIKKLGEDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY61</accession>
    <name>Q5CY61_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_3560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628519.1">
        <property type="nucleotide sequence ID" value="XM_628517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY61"/>
    <dbReference type="FunCoup" id="Q5CY61">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="GeneID" id="3372107"/>
    <dbReference type="KEGG" id="cpv:cgd7_3560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3560"/>
    <dbReference type="InParanoid" id="Q5CY61"/>
    <dbReference type="OMA" id="MFISARW"/>
    <dbReference type="OrthoDB" id="344103at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254368" evidence="2">
        <location>
            <begin position="21"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="127"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="198" mass="22962" checksum="67C67FBF19732287" modified="2005-04-12" version="1">MKISFRWILLSLIVAMDIYCQSVLIGCQIENNVSNYNNSNYLLGASGNIKDCIPNHPYMRSFFQINIIKNSLDLESFGRSLYVSFESSNEISYFLMVSAGMFAVAERILLTFFILRIIIRLFVTPIIKTLSTVLIIIVILRVMFAIYNLSESYRLYETTVILWNSLQSLFFLIDNKIYNYGDYLLQYFGMSTNQTLAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYA2</accession>
    <name>Q5CYA2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ER vesicle protein Erv41p, transmembrane region near C terminus and possible N region transmembrane</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_3130</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628478.1">
        <property type="nucleotide sequence ID" value="XM_628476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYA2"/>
    <dbReference type="STRING" id="353152.Q5CYA2"/>
    <dbReference type="GeneID" id="3372293"/>
    <dbReference type="KEGG" id="cpv:cgd7_3130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3130"/>
    <dbReference type="InParanoid" id="Q5CYA2"/>
    <dbReference type="OMA" id="QRHEGCR"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="353"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="34"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="160"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="397" mass="45786" checksum="5D5F27825D231DD4" modified="2005-04-12" version="1">MEATYGESSTLRQRKRDIVLGNIVKTNEALQTKVKKIDIYGKIHEDYCVKSTSRSIISLLVYIIVFFLTLNEIFKYFKGEMIDNIGVDNTINNKLDIMLDITFPRLRCEEISVDSVDYVGENQVDSKEYMVKIPIDLNGQEVRNIKYNQQNDLKIECMSCYGAETNEFLCCNDCDSLKTAYRSKGWSYLDIVSKAPQCIEKVGCRINGRMQVNKVSGNIHVALGTATIKNGKHVHEFNMNDVSRGFNTSHIIHELRFGSDKIPFLFSPLENIQKFVHKGTKMFHYYVKLIPTQYFSGNGEVNLYGNQYAFTERERDVHVQNGELSGLPGIFIVYDFQPFLLQKIYKRVPISHLITSFCAIVGGIYSIMSLLDTFVAWLFKNNINRYINYIYKMNYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYA7</accession>
    <name>Q5CYA7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_3060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628473.1">
        <property type="nucleotide sequence ID" value="XM_628471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYA7"/>
    <dbReference type="FunCoup" id="Q5CYA7">
        <property type="interactions" value="199"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYA7"/>
    <dbReference type="GeneID" id="3372288"/>
    <dbReference type="KEGG" id="cpv:cgd7_3060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3060"/>
    <dbReference type="InParanoid" id="Q5CYA7"/>
    <dbReference type="OMA" id="GCSFANC"/>
    <dbReference type="OrthoDB" id="2192946at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF13">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="663"/>
            <end position="953"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="983" mass="115144" checksum="B3BE4964C341873B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYC6</accession>
    <name>Q5CYC6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_2870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628454.1">
        <property type="nucleotide sequence ID" value="XM_628452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYC6"/>
    <dbReference type="STRING" id="353152.Q5CYC6"/>
    <dbReference type="GeneID" id="3372272"/>
    <dbReference type="KEGG" id="cpv:cgd7_2870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2870"/>
    <dbReference type="InParanoid" id="Q5CYC6"/>
    <dbReference type="OMA" id="NQFASAN"/>
    <dbReference type="OrthoDB" id="342630at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="940"/>
            <end position="1275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="760"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="814"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="860"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="995"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1022"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1076"/>
            <end position="1090"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1103"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1130"/>
            <end position="1144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1184"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1211"/>
            <end position="1225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1238"/>
            <end position="1252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1275" mass="145669" checksum="97D011A9330525D7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYD6</accession>
    <name>Q5CYD6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_2750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628444.1">
        <property type="nucleotide sequence ID" value="XM_628442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYD6"/>
    <dbReference type="GeneID" id="3372262"/>
    <dbReference type="KEGG" id="cpv:cgd7_2750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2750"/>
    <dbReference type="InParanoid" id="Q5CYD6"/>
    <dbReference type="OrthoDB" id="342936at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="846" mass="99301" checksum="F990D9314BA3062A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYH7</accession>
    <name>Q5CYH7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Eukaryotic translation initiation factor 5A</fullName>
            <shortName evidence="8">eIF-5A</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_2300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="PTM">
        <text evidence="8">eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the eIF-5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628403.1">
        <property type="nucleotide sequence ID" value="XM_628401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYH7"/>
    <dbReference type="FunCoup" id="Q5CYH7">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYH7"/>
    <dbReference type="GeneID" id="3371967"/>
    <dbReference type="KEGG" id="cpv:cgd7_2300"/>
    <dbReference type="InParanoid" id="Q5CYH7"/>
    <dbReference type="OMA" id="KDDVRMP"/>
    <dbReference type="OrthoDB" id="9975114at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045901">
        <property type="term" value="P:positive regulation of translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045905">
        <property type="term" value="P:positive regulation of translational termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04468">
        <property type="entry name" value="S1_eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000007">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000034">
        <property type="entry name" value="Eukaryotic translation initiation factor 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001884">
        <property type="entry name" value="IF5A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048670">
        <property type="entry name" value="IF5A-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020189">
        <property type="entry name" value="IF5A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019769">
        <property type="entry name" value="Trans_elong_IF5A_hypusine_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00037">
        <property type="entry name" value="eIF_5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11673">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 5A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01287">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21485">
        <property type="entry name" value="IF5A-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003025">
        <property type="entry name" value="eIF5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01376">
        <property type="entry name" value="eIF-5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00302">
        <property type="entry name" value="IF5A_HYPUSINE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0385">Hypusine</keyword>
    <keyword evidence="10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6 8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor 5A C-terminal" evidence="9">
        <location>
            <begin position="90"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU362005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="166" mass="17917" checksum="B7ABE9A8D3F3985E" modified="2005-04-12" version="1" fragment="single">LLLSLNMSEDEQQFDSVDAGASHCYPMAAGSIKKNGYCMLKGKPCKVVDMSTSKTGKHGHAKAHIVGLDIFTNKKYEDVCPTSHNMAVPFVKRSEYQLIDIHDNFTSLLTENGSTKDDLALPTDAEGNPDEVAIQIQQMYADGKAILVGVLAACGIEKIVSAKELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYL6</accession>
    <name>Q5CYL6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_1870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628364.1">
        <property type="nucleotide sequence ID" value="XM_628362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYL6"/>
    <dbReference type="GeneID" id="3371747"/>
    <dbReference type="KEGG" id="cpv:cgd7_1870"/>
    <dbReference type="InParanoid" id="Q5CYL6"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254391" evidence="1">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="103" mass="12433" checksum="89D9498C32BE6EC0" modified="2005-04-12" version="1">MVFSTTHIKLLILYFFFPLRYPQNETRSQKNKNVRRPSTFIQRQHIWTNSVRGNFSRRSKLKNQGSKVLNFSNYNKKFLIHIIRENGKFYEVRSFPFNGSDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYL7</accession>
    <name>Q5CYL7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P24 like gold domain protein, possible transmembrane region near C-terminus, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_1860</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628363.1">
        <property type="nucleotide sequence ID" value="XM_628361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYL7"/>
    <dbReference type="FunCoup" id="Q5CYL7">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYL7"/>
    <dbReference type="GeneID" id="3371746"/>
    <dbReference type="KEGG" id="cpv:cgd7_1860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1860"/>
    <dbReference type="InParanoid" id="Q5CYL7"/>
    <dbReference type="OMA" id="QEKMMET"/>
    <dbReference type="OrthoDB" id="62956at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="33"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="203" mass="23556" checksum="B4FAB22810980EC8" modified="2005-04-12" version="1">MKIEPIYFVVIVFIALFPFNTDALYFILNPGYTECIHFHAKKADHIVGSFEIDSAYEGVRVSLFENKESSKILDKIENSGDFSINAPKDTEYQLCFKNLMNSVQQTVNFSIKNMAYNSNINNVMSNIESKKLIESMEKLYERITVASEKQRYALTRKRFQMEAIESSRKKAAIWSILELLLSFGLVAIQVYYIKSYFQVKYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYS6</accession>
    <name>Q5CYS6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ser/Thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_1190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628304.1">
        <property type="nucleotide sequence ID" value="XM_628302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYS6"/>
    <dbReference type="STRING" id="353152.Q5CYS6"/>
    <dbReference type="GeneID" id="3371849"/>
    <dbReference type="KEGG" id="cpv:cgd7_1190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1190"/>
    <dbReference type="InParanoid" id="Q5CYS6"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345:SF91">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PLK4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="203"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="754"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="762"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="780"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="827" mass="94418" checksum="2DB0F728A1CE92EA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYT4</accession>
    <name>Q5CYT4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_1100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628296.1">
        <property type="nucleotide sequence ID" value="XM_628294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYT4"/>
    <dbReference type="GeneID" id="3371842"/>
    <dbReference type="KEGG" id="cpv:cgd7_1100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1100"/>
    <dbReference type="InParanoid" id="Q5CYT4"/>
    <dbReference type="OrthoDB" id="340324at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="637"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="670" mass="76179" checksum="59E704E91BFBFE9E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYT6</accession>
    <name>Q5CYT6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">eIF3-p47 with JAB/PAD domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_1080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628294.1">
        <property type="nucleotide sequence ID" value="XM_628292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYT6"/>
    <dbReference type="FunCoup" id="Q5CYT6">
        <property type="interactions" value="559"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYT6"/>
    <dbReference type="GeneID" id="3372002"/>
    <dbReference type="KEGG" id="cpv:cgd7_1080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1080"/>
    <dbReference type="InParanoid" id="Q5CYT6"/>
    <dbReference type="OMA" id="EYFVHFH"/>
    <dbReference type="OrthoDB" id="25498at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF6">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="1">
        <location>
            <begin position="40"/>
            <end position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="349" mass="38973" checksum="10C3927CF9EBAEB2" modified="2005-04-12" version="1">MSIYCAQNNIISESDGFLISHLSDTNLTFDSLSKPSIISCRVNPLVILSILDSHLRRQSGHQYVIGTLLGYINEGGNVIVTDSFVDRHSFTDDGMLSIMIDTHETMFELKQKTNSRLQVIGWYSTCSGINSVSCAVNNWFKTDIGSSKFQQTPLLSEPIHIVVDPSFSNGKLSINGYIQIQSTWTNSIVSIFRPIPLDIVASPCERLHISRILRPLLEKHHLNAVGIPPKSLPRTILGPEDEICTVLPLNNSNYSLQSGDVSQLLTKLILLVQRCQNYVKKVLSGEVSMDPMIGRQIDYAIHSIYDFEYNIYNIIKSNSTQDALIIGCLTELTRVQLSLSEKLQSLIIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYY9</accession>
    <name>Q5CYY9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase II subunit RPB9-like zinc ribbon domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_505</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628241.1">
        <property type="nucleotide sequence ID" value="XM_628239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYY9"/>
    <dbReference type="FunCoup" id="Q5CYY9">
        <property type="interactions" value="270"/>
    </dbReference>
    <dbReference type="GeneID" id="3371858"/>
    <dbReference type="KEGG" id="cpv:cgd7_505"/>
    <dbReference type="InParanoid" id="Q5CYY9"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase II subunit RPB9-like zinc ribbon" evidence="1">
        <location>
            <begin position="3"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="108" mass="12768" checksum="92C4BEDCD9127F1B" modified="2005-04-12" version="1">MVQFCIHCHNILLLKEHEERMAFYCPTCPYVFKIVSQISKVTDFVPKKMEEPSIDMNEIASSKTMGKLRLYSGSTIICRRDLYLLLYYTNKLYLYIQSIIYQLIKKGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYZ2</accession>
    <name>Q5CYZ2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-lactate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_480</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2006-01" db="PDB data bank">
            <title>Structure of cryptosporidium parvum lactate dehydrogenase in complex with substrates and cofactors.</title>
            <authorList>
                <person name="Senkovich O.A."/>
                <person name="Chattopadhyay D."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 17-337 IN COMPLEX WITH (R)-LACTATE AND NAD(+)</scope>
    </reference>
    <reference evidence="13 14 15" key="3">
        <citation type="journal article" date="2015" name="Int. J. Biol. Macromol." volume="74" first="608" last="619">
            <title>Biochemical and structural characterization of Cryptosporidium parvum Lactate dehydrogenase.</title>
            <authorList>
                <person name="Cook W.J."/>
                <person name="Senkovich O."/>
                <person name="Hernandez A."/>
                <person name="Speed H."/>
                <person name="Chattopadhyay D."/>
            </authorList>
            <dbReference type="PubMed" id="25542170"/>
            <dbReference type="DOI" id="10.1016/j.ijbiomac.2014.12.019"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 17-337 IN COMPLEX WITH (S)-LACTATE; NAD(+) AND PYRUVATE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628238.1">
        <property type="nucleotide sequence ID" value="XM_628236.1"/>
    </dbReference>
    <dbReference type="PDB" id="2FN7">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A/B=17-337"/>
    </dbReference>
    <dbReference type="PDB" id="4ND1">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="A/B=17-337"/>
    </dbReference>
    <dbReference type="PDB" id="4ND2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B=17-337"/>
    </dbReference>
    <dbReference type="PDB" id="4ND3">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.05 A"/>
        <property type="chains" value="A/B=17-337"/>
    </dbReference>
    <dbReference type="PDB" id="4ND4">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A/B=17-337"/>
    </dbReference>
    <dbReference type="PDB" id="4ND5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="A/B/C/D=17-337"/>
    </dbReference>
    <dbReference type="PDBsum" id="2FN7"/>
    <dbReference type="PDBsum" id="4ND1"/>
    <dbReference type="PDBsum" id="4ND2"/>
    <dbReference type="PDBsum" id="4ND3"/>
    <dbReference type="PDBsum" id="4ND4"/>
    <dbReference type="PDBsum" id="4ND5"/>
    <dbReference type="AlphaFoldDB" id="Q5CYZ2"/>
    <dbReference type="SMR" id="Q5CYZ2"/>
    <dbReference type="FunCoup" id="Q5CYZ2">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYZ2"/>
    <dbReference type="GeneID" id="3371768"/>
    <dbReference type="KEGG" id="cpv:cgd7_480"/>
    <dbReference type="InParanoid" id="Q5CYZ2"/>
    <dbReference type="OMA" id="ASCAEYI"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CYZ2"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01339">
        <property type="entry name" value="LDH-like_MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000018">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029752">
        <property type="entry name" value="D-isomer_DH_CS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011275">
        <property type="entry name" value="Malate_DH_type3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004863">
        <property type="entry name" value="PRK06223.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00065">
        <property type="entry name" value="D_2_HYDROXYACID_DH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12 13 14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 6" id="KW-0520">NAD</keyword>
    <keyword evidence="12 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="2 7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="9">
        <location>
            <begin position="165"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="193"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="27"/>
            <end position="32"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13 15">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13 15">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6 12 13">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13 15">
        <location>
            <position position="97"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>(R)-lactate</name>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>(S)-lactate</name>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="136"/>
            <end position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13 15">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>(R)-lactate</name>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>(S)-lactate</name>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13 15">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12 13 15">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
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        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>(R)-lactate</name>
            <dbReference type="ChEBI" id="CHEBI:16004"/>
        </ligand>
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        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>(S)-lactate</name>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>(S)-lactate</name>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 15 16">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 16">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="2FN7"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="4ND1"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="4ND2"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="4ND3"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="4ND4"/>
        </source>
    </evidence>
    <sequence length="337" mass="35876" checksum="9DC3F863740814EB" modified="2005-04-12" version="1" fragment="single">SEFLFSKHLFIFFILKMIERRKIAVIGSGQIGGNIAYIVGKDNLADVVLFDIAEGIPQGKALDITHSMVMFGSTSKVIGTNDYADISGSDVVIITASIPGRPKDDRSELLFGNARILDSVAEGVKKYCPNAFVICITNPLDVMVSHFQKVSGLPHNKVCGMAGVLDSSRFRTFIAQHFGVNASDVSANVIGGHGDGMVPVTSSVSVGGVPLSSFIKQGLITQEQIDEIVCHTRIAWKEVADNLKTGTAYFAPAAAAVKMAEAYLKDKKAVVPCSAFCSNHYGVKGIYMGVPTIIGKNGVEDILELDLTPLEQKLLGESINEVNTISKVLDNAPAAGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ05</accession>
    <name>Q5CZ05_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Transmembrane 9 superfamily member</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628225.1">
        <property type="nucleotide sequence ID" value="XM_628223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ05"/>
    <dbReference type="FunCoup" id="Q5CZ05">
        <property type="interactions" value="443"/>
    </dbReference>
    <dbReference type="GeneID" id="3371765"/>
    <dbReference type="KEGG" id="cpv:cgd7_330"/>
    <dbReference type="InParanoid" id="Q5CZ05"/>
    <dbReference type="OMA" id="LEVHWLS"/>
    <dbReference type="OrthoDB" id="1666796at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072657">
        <property type="term" value="P:protein localization to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004240">
        <property type="entry name" value="EMP70"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766:SF177">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10766">
        <property type="entry name" value="TRANSMEMBRANE 9 SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02990">
        <property type="entry name" value="EMP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="307"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="504"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="581"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="613" mass="71949" checksum="FCD847D8B4406435" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPR9</accession>
    <name>A3FPR9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_5050</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388415.1">
        <property type="nucleotide sequence ID" value="XM_001388378.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPR9"/>
    <dbReference type="GeneID" id="3371817"/>
    <dbReference type="KEGG" id="cpv:cgd7_5050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5050"/>
    <dbReference type="InParanoid" id="A3FPR9"/>
    <dbReference type="OMA" id="IRISSKW"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1395" mass="160874" checksum="8D590FCBF47B307A" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPX3</accession>
    <name>A3FPX3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388352.1">
        <property type="nucleotide sequence ID" value="XM_001388315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPX3"/>
    <dbReference type="STRING" id="353152.A3FPX3"/>
    <dbReference type="GeneID" id="3375977"/>
    <dbReference type="KEGG" id="cpv:cgd6_4720"/>
    <dbReference type="InParanoid" id="A3FPX3"/>
    <dbReference type="OrthoDB" id="341965at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="165" mass="18570" checksum="67AB7918B6E0E41B" modified="2007-04-03" version="1" fragment="single">MERWIRNLMCKKAVRCLRQQQTAGRIRCKNGGLASTGSSTGTGCPLSSQRPCEACSSLKGVVLYPLTENVGIEEIKMDDDIKEMWKSLISKKGMNLEDIIRTTKGEMAVRKLLGLDKTSNSSESTSKRRQNKTSSSNNMELKRRRIKIRNSHIFNNSDELFAPNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ72</accession>
    <name>A3FQ72_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd2_1830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388208.1">
        <property type="nucleotide sequence ID" value="XM_001388171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ72"/>
    <dbReference type="STRING" id="353152.A3FQ72"/>
    <dbReference type="GeneID" id="3373447"/>
    <dbReference type="KEGG" id="cpv:cgd2_1830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1830"/>
    <dbReference type="InParanoid" id="A3FQ72"/>
    <dbReference type="OMA" id="MLVHHAL"/>
    <dbReference type="OrthoDB" id="3638488at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000086">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF418">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE WARTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="1"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="11">
        <location>
            <begin position="302"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="381" mass="44410" checksum="366254CB824AB56E" modified="2007-04-03" version="1" fragment="single">MRKSIIRTKNQLERIYNERALLAQNASDFVVKLFYTFQDDKHLYQVMEYLPGGDLMSYLIKYDKFSEEDTRFYMAQLVHAVDLVHQLGFVHRDVKPDNIVLDSKGHLKLLDFGLCKFSPLIEGDENREYQTENHLRCVNLNAKSHKDSNKASEISFNENNENKRINKELYRGSNLLEEKNCQNEDLNTSLKHLDRKTIHSTVGTPQYMAPEIFLRQGYTHLVDWWSVGILMYECLYGGVPFNDDTHNPIKVAIKVMQWEKLLLLPHPCRKISPEALDLLKNLLCHPSKRFDGEQIKKHPFFNEIDWDKLRQCPAPFNKQINENIYKSNVTAAELIDESPNNTRYGVQGSSLVDINFLDYTYRNKDRNNDPISIGEAIKMCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQA9</accession>
    <name>A3FQA9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_4330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Part of the multisubunit transport protein particle (TRAPP) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Golgi apparatus</location>
            <location evidence="7">cis-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAPP small subunits family. TRAPPC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388245.1">
        <property type="nucleotide sequence ID" value="XM_001388208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQA9"/>
    <dbReference type="FunCoup" id="A3FQA9">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQA9"/>
    <dbReference type="GeneID" id="3373662"/>
    <dbReference type="KEGG" id="cpv:cgd2_4330"/>
    <dbReference type="InParanoid" id="A3FQA9"/>
    <dbReference type="OMA" id="MPIRTEG"/>
    <dbReference type="OrthoDB" id="246406at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14856">
        <property type="entry name" value="TRAPPC4_synbindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007233">
        <property type="entry name" value="TRAPPC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23249:SF15">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04099">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01399">
        <property type="entry name" value="Sybindin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="5 7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="137" mass="15888" checksum="6CFF2017CBF8C698" modified="2007-04-03" version="1" fragment="single">YSLYINNKNGSLIYQRDFSDIPLTANDRIRLASTFHGLCTIARQISPIKTKRLDDYIQTSNGISSISTELFRLECFETLTGLRFFLIASKDAQGLNELLHKVYQGYTDYVLKNPFHDLDMPIRSILFDKEIDRIFLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQM8</accession>
    <name>A3FQM8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_32</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAZ51234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388046.1">
        <property type="nucleotide sequence ID" value="XM_001388009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQM8"/>
    <dbReference type="GeneID" id="4910866"/>
    <dbReference type="KEGG" id="cpv:cgd4_32"/>
    <dbReference type="InParanoid" id="A3FQM8"/>
    <dbReference type="OMA" id="NDSCYST"/>
    <dbReference type="OrthoDB" id="342849at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="497" mass="55912" checksum="7D1C4ADF887D521B" modified="2007-04-03" version="1" fragment="single">NRDLQNPLLAFPLPTNQLAVATQFYDENFQEKWVLRSGFSGKSYVYFKIDFIKTIIIGYVPNLGLVLDSTILHPENIKTPYDQLNKNDANDKETVVSDANDKETDVSDTNEEQASNEYLIPVEQNKIENGGTLSFNITIGNFKNDLFLIISDKDKKQMINLELSKCCGKLIDSINENYDRFSYPEELMASNAIDLNLTWQSSIYALKTKSSDTPLAIIPIENKSIPYQAVLLNSSTREELKTNWSYTTGVKNLSSVSCTINALEGRCKSSSVTVTKMVNPNIEFLRFGFLFSKDTLAPFEMTISQNSNNLATLQISSNVIKVQSSDSEEITLKKEFTTGEWVSGDIFIISDDIHNVIEEDSSISCKNYNDSCYSTQNSQDWMGIVSEKSILRYAYLKKQAVENKVKTDTNTEADSSSSSSKTQYYLYISFKNCIIAKLNINSNSFNKVSVSNRQGSSNLVYWRLKGGVSTSINIPDSYLDNLKTDIPKEIEANTNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQP3</accession>
    <name>A3FQP3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Beta-catenin-like protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_3800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAZ51228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388290.1">
        <property type="nucleotide sequence ID" value="XM_001388253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQP3"/>
    <dbReference type="FunCoup" id="A3FQP3">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQP3"/>
    <dbReference type="GeneID" id="3372562"/>
    <dbReference type="KEGG" id="cpv:cgd5_3800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3800"/>
    <dbReference type="InParanoid" id="A3FQP3"/>
    <dbReference type="OrthoDB" id="1898821at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039678">
        <property type="entry name" value="CTNNBL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013180">
        <property type="entry name" value="CTNNBL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978:SF0">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14978">
        <property type="entry name" value="BETA-CATENIN-LIKE PROTEIN 1 NUCLEAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08216">
        <property type="entry name" value="CTNNBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Beta-catenin-like protein 1 N-terminal" evidence="7">
        <location>
            <begin position="192"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08216"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="367" mass="43225" checksum="33C2AAFC3EE5D6C8" modified="2007-04-03" version="1">MTQDKRTRISAEIEDSEGESSNHKKINIENEQEISEIVQLLKKHIRNFEMEKVYYIFEKINQREIFFKDIEDYLNVNFSKVINECLLGLNIILLPDHDQVIINGLKIKILKLILNILLDISEFQDESSQIGENSNINSIKLKLLLENDLRLSLLKSIKSIEHIYLQTLKADNISKKEDQNFEELISHESELLQESVLETYFQLLESTIEIDPENVSKEFTEFEELFDWLIQILDDEESSIVDEITSLKMEILSIIFQYIKLSQESTIWKKTNKKQFMDKFLVKLANLALRDTEIGGIKEKEFLHNIIDIICNLLFEEEMRKEFCDLQGLELMIKLMKEKTSMRHLSIKVVSFAMLDKGEMNNKFIQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQQ6</accession>
    <name>A3FQQ6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">XTP/dITP diphosphatase</fullName>
            <ecNumber evidence="10">3.6.1.66</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd4_4150</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ITP + H2O = IMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29399"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="ChEBI" id="CHEBI:61402"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29400"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-hydroxy-dATP + H2O = N(6)-hydroxy-dAMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:83971"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:233529"/>
            <dbReference type="ChEBI" id="CHEBI:233530"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:83972"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>dITP + H2O = dIMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:28342"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61194"/>
            <dbReference type="ChEBI" id="CHEBI:61382"/>
            <dbReference type="EC" id="3.6.1.66"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:28343"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAM1 NTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.66" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAZ51218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388085.1">
        <property type="nucleotide sequence ID" value="XM_001388048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQQ6"/>
    <dbReference type="FunCoup" id="A3FQQ6">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQQ6"/>
    <dbReference type="GeneID" id="3372412"/>
    <dbReference type="KEGG" id="cpv:cgd4_4150"/>
    <dbReference type="InParanoid" id="A3FQQ6"/>
    <dbReference type="OMA" id="YDPIFQP"/>
    <dbReference type="OrthoDB" id="6288734at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036220">
        <property type="term" value="F:ITP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009143">
        <property type="term" value="P:nucleoside triphosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009117">
        <property type="term" value="P:nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00515">
        <property type="entry name" value="HAM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.950.10:FF:000003">
        <property type="entry name" value="Inosine triphosphate pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.950.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002637">
        <property type="entry name" value="RdgB/HAM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067:SF9">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11067">
        <property type="entry name" value="INOSINE TRIPHOSPHATE PYROPHOSPHATASE/HAM1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01725">
        <property type="entry name" value="Ham1p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00054940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00066468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00093218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00093255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAZ51218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="205" mass="23872" checksum="5278EDC678FF4F0E" modified="2007-04-03" version="1" fragment="single">YLYIGNKKKAEEFLKILDGKLDIELVDIDLPEFQGSPEEITLHKCKSAYEKIKKPVFVEDTSLCFNAYNGLPGPYVKWFLKSVGAQGLYNMLEAYQDKSAYAMTLIGYYDETKMSDPIIFKGKIDGEIVKPRGEKGFSWDPIFKPNGHSLAFSEMDMDVKNQISHRYLCLLKVLVSFFIILYTLYIITFHFYYIYIYLFLLHNIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPG0</accession>
    <name>Q5CPG0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zfwd1 protein, CCCH like RNA binding domain fused to WD repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625333.1">
        <property type="nucleotide sequence ID" value="XM_625333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPG0"/>
    <dbReference type="FunCoup" id="Q5CPG0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPG0"/>
    <dbReference type="GeneID" id="3372340"/>
    <dbReference type="KEGG" id="cpv:cgd3_200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_200"/>
    <dbReference type="InParanoid" id="Q5CPG0"/>
    <dbReference type="OMA" id="FNPYGYL"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="402" mass="44041" checksum="37DB8891C4B447DA" modified="2005-04-12" version="1">MRGRWKGGKGGHGGSSSGGSNTKVSEICRHFVQQGNCKFGQNCNYSHILRQVAQIQKAHFGGIRCAISSPLPTGELELFTGGCDGQLKRWIIRPADKDVMTTEPERGSNHRRRNYQNKFQNDVSGATQLSVKMDSAINCSAEVCSCLIYGDVLFCGLINGTIRAFHKPTGNFTDLVGHNQEIHQLLIIDNILVSACWGGKIVFWKFDQASGTFIISAQIQAKEHIKCLKYFPYKGNSAGAMGQPQCQIQDASPHLWVCGGGIVQIVDLITLQVVREIIFDGGPIMSVLEYENHLVLCSLQGVIRVISPTGEETFRKSLGSPALCMDGTVTADAKHILMMGQNNGHLRCITLPLFDSVLEFHTPDTRSEIRLVSNLGGSPGIILTAQWDGALNFYQWCLPKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPL5</accession>
    <name>Q5CPL5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625406.1">
        <property type="nucleotide sequence ID" value="XM_625406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPL5"/>
    <dbReference type="SMR" id="Q5CPL5"/>
    <dbReference type="STRING" id="353152.Q5CPL5"/>
    <dbReference type="GeneID" id="3372381"/>
    <dbReference type="KEGG" id="cpv:cgd2_390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_390"/>
    <dbReference type="InParanoid" id="Q5CPL5"/>
    <dbReference type="OrthoDB" id="10520140at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254352" evidence="2">
        <location>
            <begin position="26"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="155" mass="17438" checksum="17908C38CF1AED06" modified="2005-04-12" version="1">MSIKKFRSLLTTLVLILFLFNYEHNEQETTNRVVLDHSFLNLRRPSIRKLMRCFGCCRGKCKKKPSKKKGFTLPPPPARSCLKKTGQNSQSQEGNQGVSPKRVTFDLGNKPRSGIKSTVGGLPSSSSPPLRVMLGLERPDTTKNEDNSEEIETKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPT3</accession>
    <name>Q5CPT3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_4140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625431.1">
        <property type="nucleotide sequence ID" value="XM_625431.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPT3"/>
    <dbReference type="GeneID" id="3372404"/>
    <dbReference type="KEGG" id="cpv:cgd4_4140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4140"/>
    <dbReference type="InParanoid" id="Q5CPT3"/>
    <dbReference type="OMA" id="CIVATEF"/>
    <dbReference type="OrthoDB" id="272077at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1415"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="64"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1151"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="64"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="103"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="131"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1154"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1192"/>
            <end position="1208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1445" mass="167083" checksum="B5A856F89D69677D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPV7</accession>
    <name>Q5CPV7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">26S proteasome regulatory complex, subunit PSMD5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625522.1">
        <property type="nucleotide sequence ID" value="XM_625522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPV7"/>
    <dbReference type="STRING" id="353152.Q5CPV7"/>
    <dbReference type="GeneID" id="3372463"/>
    <dbReference type="KEGG" id="cpv:cgd8_630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_630"/>
    <dbReference type="InParanoid" id="Q5CPV7"/>
    <dbReference type="OMA" id="CCAIAAW"/>
    <dbReference type="OrthoDB" id="10250600at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019538">
        <property type="entry name" value="PSMD5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554:SF10">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13554">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10508">
        <property type="entry name" value="Proteasom_PSMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0647">Proteasome</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="505" mass="57478" checksum="CD43A7EEA2B9E235" modified="2005-04-12" version="1">MGSNLDNDLKKKLQVFLASPLCKESYNELSNVISIIGLLELLLNSNTMDDITLITEVLKRLTILGVLDDAIFDIPNSIEMLEKGSRSQTECIRLLVAFILNSLSMDELKCKKACEKGFFSVLGLLLRDIDISIGESASKTLKSISKSNPEFVYDQNLINKLLENFKSLKDETRLRIIDTYISIGSVSEDLFNKCQEKGEFYSLALKEYFTEDILLKLVSMKLLEDLGEYNWGVKFIINNSTPELLIDDLNNPMFDDEIKISIVYLLSKMVNNNPELSQKILTMSGNSFVQTFKEFMGSYNSISCSEDYLKSVCAINCWGLFASNLISFQNLMNVWEDSFHLMLKLVSNSKSEISLSSLNSWVTFFESKDINQILNQTKTTFGLKQSIETQLLPIIISDLISKPFPENRTLIYKILTLMIPYFSNITSNLISNSKIRDILLNPNSDSNKDILYIKYDLVKQMVKYDQNTINNIPDPNFSSSLQEYVKVGPFYKSSSAEMQIQDITM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPX7</accession>
    <name>Q5CPX7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein with long stretch of threonines, putative mucin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625502.1">
        <property type="nucleotide sequence ID" value="XM_625502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPX7"/>
    <dbReference type="GeneID" id="3372451"/>
    <dbReference type="KEGG" id="cpv:cgd8_410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_410"/>
    <dbReference type="InParanoid" id="Q5CPX7"/>
    <dbReference type="OrthoDB" id="343139at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="813"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="845"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="860"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="873"/>
            <end position="885"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="905" mass="103899" checksum="9832A530C4D57903" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ30</accession>
    <name>Q5CQ30_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_4340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625596.1">
        <property type="nucleotide sequence ID" value="XM_625596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ30"/>
    <dbReference type="GeneID" id="3372580"/>
    <dbReference type="KEGG" id="cpv:cgd5_4340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4340"/>
    <dbReference type="InParanoid" id="Q5CQ30"/>
    <dbReference type="OMA" id="CSCNNIY"/>
    <dbReference type="OrthoDB" id="342761at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="117" mass="14129" checksum="8CD2FE42687D098D" modified="2005-04-12" version="1">MSRKIELVRELCDEIKYLRRLCRENNIEYKREITSHLEDEESIINSFEFDSMTETLLLLNNVSKYNSIFLDENSERKELNNEKLRQIKSIIDIKGEIKVSYNNNIKILLKCIYKFNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ62</accession>
    <name>Q5CQ62_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_4000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625564.1">
        <property type="nucleotide sequence ID" value="XM_625564.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372516"/>
    <dbReference type="KEGG" id="cpv:cgd5_4000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4000"/>
    <dbReference type="InParanoid" id="Q5CQ62"/>
    <dbReference type="OrthoDB" id="342086at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="103"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="677" mass="79125" checksum="02F5B2510C9765DD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ89</accession>
    <name>Q5CQ89_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_3720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625537.1">
        <property type="nucleotide sequence ID" value="XM_625537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ89"/>
    <dbReference type="FunCoup" id="Q5CQ89">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ89"/>
    <dbReference type="GeneID" id="3372585"/>
    <dbReference type="KEGG" id="cpv:cgd5_3720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3720"/>
    <dbReference type="InParanoid" id="Q5CQ89"/>
    <dbReference type="OMA" id="MKRIQQG"/>
    <dbReference type="OrthoDB" id="1727351at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.60.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.60.20">
        <property type="entry name" value="Ribosomal protein S17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00511">
        <property type="entry name" value="Ribosomal_eS17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001210">
        <property type="entry name" value="Ribosomal_eS17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018273">
        <property type="entry name" value="Ribosomal_eS17_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036401">
        <property type="entry name" value="Ribosomal_eS17_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002242">
        <property type="entry name" value="PRK01151.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10732:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00833">
        <property type="entry name" value="Ribosomal_S17e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116820">
        <property type="entry name" value="Rps17e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00712">
        <property type="entry name" value="RIBOSOMAL_S17E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="131" mass="14976" checksum="CCE6A931F4D357C0" modified="2005-04-12" version="1">MGRVRTKTVKRAARLIVEKYVSKLTLDFQTNKKIAEEVASIPTKRLRNKIAGFVTHLMRRIQKGPVRGISLKLQEEERERRMEKLPDKSEVDLDVILVDQDTKDMLVGLGLDIPVEVVSPTRVFQGKSGRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQA3</accession>
    <name>Q5CQA3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA primase</fullName>
            <ecNumber evidence="9">2.7.7.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_1490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic-type primase small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.-" evidence="9"/>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625745.1">
        <property type="nucleotide sequence ID" value="XM_625745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQA3"/>
    <dbReference type="FunCoup" id="Q5CQA3">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQA3"/>
    <dbReference type="GeneID" id="3372610"/>
    <dbReference type="KEGG" id="cpv:cgd4_1490"/>
    <dbReference type="InParanoid" id="Q5CQA3"/>
    <dbReference type="OMA" id="NVTRGFN"/>
    <dbReference type="OrthoDB" id="19606at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04860">
        <property type="entry name" value="AE_Prim_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.920.10">
        <property type="entry name" value="DNA primase, PRIM domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002755">
        <property type="entry name" value="DNA_primase_S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014052">
        <property type="entry name" value="DNA_primase_ssu_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00335">
        <property type="entry name" value="primase_sml"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10536">
        <property type="entry name" value="DNA PRIMASE SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01896">
        <property type="entry name" value="DNA_primase_S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56747">
        <property type="entry name" value="Prim-pol domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 9" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="3 9" id="KW-0639">Primosome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="402" mass="47309" checksum="EDCAE797D1C57626" modified="2005-04-12" version="1" fragment="single">LNFISYIIIQLDNSRQNNLIQNREFSMTIKSEIDQDEIYLRWQHFKTIDQLKQEIVARTPHKFDIGAIYNIPISEKEISPLGFKPVQRELVFDIDMNDYDDIRTCCQEKTICEKCWLYVTVAIRLIDTSLRQDFGFKHILWLYSGRRGVHCWVCDTKARLLPSEARTAIIDYLTLVTGNENRKKKVNLKTSNNQNGIKSHPFIDRCFNICMQYFDQILENQQIFDHNSIHIEKVLNHLSEDTKVYQTVQNWIQKTSDFTCLEFWDFLSNTLQKSSDKSHLTLLKEIVFAYSYPRLDINVSKDLGHLLKAPFCIHHSTGRLCIPIDTSQNFNFNPKTVPTLTSIRNDYDNNVCQKDIKSNTTTYTIPSSISKYIQFMDNFVDNLIQDTKKEQEEYNIMLQLIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQA4</accession>
    <name>Q5CQA4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">BMS1 like GTpase involved in ribosome biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd4_1480</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. BMS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625744.1">
        <property type="nucleotide sequence ID" value="XM_625744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQA4"/>
    <dbReference type="FunCoup" id="Q5CQA4">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQA4"/>
    <dbReference type="GeneID" id="3372612"/>
    <dbReference type="KEGG" id="cpv:cgd4_1480"/>
    <dbReference type="InParanoid" id="Q5CQA4"/>
    <dbReference type="OMA" id="KLHVPMV"/>
    <dbReference type="OrthoDB" id="10260897at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01882">
        <property type="entry name" value="BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000105">
        <property type="entry name" value="BMS1 ribosome biogenesis factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037875">
        <property type="entry name" value="Bms1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030387">
        <property type="entry name" value="G_Bms1/Tsr1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF2">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BMS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51714">
        <property type="entry name" value="G_BMS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Bms1-type G" evidence="12">
        <location>
            <begin position="41"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="346"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="608"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="398"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="640"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00061391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK87712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1051" mass="121562" checksum="E295420C0049BBF3" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQE2</accession>
    <name>Q5CQE2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pre-mRNA-splicing factor CWC26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625706.1">
        <property type="nucleotide sequence ID" value="XM_625706.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQE2"/>
    <dbReference type="STRING" id="353152.Q5CQE2"/>
    <dbReference type="GeneID" id="3372675"/>
    <dbReference type="KEGG" id="cpv:cgd4_1090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1090"/>
    <dbReference type="InParanoid" id="Q5CQE2"/>
    <dbReference type="OMA" id="MISPNNA"/>
    <dbReference type="OrthoDB" id="6022at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070274">
        <property type="term" value="C:RES complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018609">
        <property type="entry name" value="Bud13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051112">
        <property type="entry name" value="CWC26_splicing_factor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31809:SF0">
        <property type="entry name" value="BUD13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09736">
        <property type="entry name" value="Bud13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="177" mass="20939" checksum="2C2563E2846F7F48" modified="2005-04-12" version="1">MKGSVVYRDEEGRIIDKELWYEKKINEKRKSKKRSIKNENKFTKDPEFVKYSGGIIQYEEAKKKYAGENNPVIQDEIIDGGRYYLSKSYDDELKKKDIWDDPIKLINAQDNNINNSGLRSDFVDLEAKRLKCKFITPQNRFSIESGYRWDGVIRGNGFEENYLIKKNEKNNTIYNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQF9</accession>
    <name>Q5CQF9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_870</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625689.1">
        <property type="nucleotide sequence ID" value="XM_625689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQF9"/>
    <dbReference type="GeneID" id="3372695"/>
    <dbReference type="KEGG" id="cpv:cgd4_870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_870"/>
    <dbReference type="InParanoid" id="Q5CQF9"/>
    <dbReference type="OMA" id="YEMEENS"/>
    <dbReference type="OrthoDB" id="342362at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="221"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="516"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="684"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="526"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="547"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="692"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1024" mass="118396" checksum="A12F4C4BA676F684" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQJ1</accession>
    <name>Q5CQJ1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625657.1">
        <property type="nucleotide sequence ID" value="XM_625657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQJ1"/>
    <dbReference type="GeneID" id="3372726"/>
    <dbReference type="KEGG" id="cpv:cgd4_520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_520"/>
    <dbReference type="InParanoid" id="Q5CQJ1"/>
    <dbReference type="OrthoDB" id="342097at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="385" mass="44136" checksum="B6FC4D401902C729" modified="2005-04-12" version="1">MMRSKRLSYIPTFEDENDFKSNDLKKEMNDQAMEIDNDCGCDYEDLVTRDNTENEREDGEIEMIDENDENEQEEGLYKDIDGDDEDDYEESEEGSDTIFPLISEPLKTFVTVNPATLEDEELWPLSSLKSLCEYVGISVKGNRRCILNRLQAWNGAPLSGAGHPDSYDTRSARFHTVPMAFLEKNKVDQRNKTRSCLENKMEKNRSSLGMKDSLNENGNIVGEHREFDESEGKSNNLKSFHSPCIIKRMESLTSTPVTSSKREIKSCLNTTSTPRKKLTQTSKSAGRICFSPYNHVRVFVSNPGERELNMDPDSILRLIDDYDYEFEEDDNRLLGESCNTNTNNLVNEFQNKETFLITNKDYVDEENSNKSNFWSNSASVFASNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQS9</accession>
    <name>Q5CQS9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_3470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625923.1">
        <property type="nucleotide sequence ID" value="XM_625923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQS9"/>
    <dbReference type="GeneID" id="3372864"/>
    <dbReference type="KEGG" id="cpv:cgd4_3470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3470"/>
    <dbReference type="InParanoid" id="Q5CQS9"/>
    <dbReference type="OrthoDB" id="343525at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254272" description="Transmembrane protein" evidence="3">
        <location>
            <begin position="18"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="58"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="441" mass="49618" checksum="19E9763434BA67A2" modified="2005-04-12" version="1">MRLYSYFLLVIFYFVCCNLHKLDTVDCIKLHKGANDNVQTKDESKEGSKDMSEEEQSTQETSSDSSNNDNDNDISSGTEEKSDSETEKGEDNKSGTSGAIDEKNDENANTDSKEEQNNATNGQDGSLLKGDKMEDESIGNQIKDAAKEEDEKNELKKLEEFKKSETLDKEPEIEKEPSENHVENEKKYEIESEIISKTSTSISEVRMTDENEFTIDHPTVNQVINKVIQPSTEEKQLQIELKDDFEPESGIDESKQTKSVILTFDLSSEDLFSKISLISDSKLTLTRYIGMNPQKVKITLVDPTIRFGSQQTRLSELAKYESMQFELNQKVPGKADVISLSEISNQIPIILQQHNTTTLRFLLEAVDSQTQFGILSNMDGVGPTIVLELKPTVESNSTWMYTITGVAVIVVIIGVSIALYFQNKNKESQRIENMPLLNNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQV0</accession>
    <name>Q5CQV0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_3210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625902.1">
        <property type="nucleotide sequence ID" value="XM_625902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQV0"/>
    <dbReference type="GeneID" id="3372786"/>
    <dbReference type="KEGG" id="cpv:cgd4_3210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3210"/>
    <dbReference type="InParanoid" id="Q5CQV0"/>
    <dbReference type="OMA" id="NDYFWIL"/>
    <dbReference type="OrthoDB" id="342824at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="225" mass="25733" checksum="8D184AEC7D29B3E6" modified="2005-04-12" version="1">MNRLVNQITATSIPETIECDLSKKKDGKFFILESKNDISSAKELYKGFRNGLRSNCNIQNHLHFENRLKDLVLRISSDQDFTLNDDQDLDDDVTCLSVQSKEDIMQILEKSRKLNKENIQVIDGVEILLSGQGGRPFAKLDKDFNTQKVETREFEPEQRAQILRELDSLLISTLKCTAEVDRLSQINANSNINHCPNSSVSRNINEMRSLITELYLNSFKGTHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR24</accession>
    <name>Q5CR24_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_2400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625828.1">
        <property type="nucleotide sequence ID" value="XM_625828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR24"/>
    <dbReference type="FunCoup" id="Q5CR24">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR24"/>
    <dbReference type="GeneID" id="3372947"/>
    <dbReference type="KEGG" id="cpv:cgd4_2400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2400"/>
    <dbReference type="InParanoid" id="Q5CR24"/>
    <dbReference type="OMA" id="EVWKQGI"/>
    <dbReference type="OrthoDB" id="9739313at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00463">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.440.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000054">
        <property type="entry name" value="Ribosomal_eL31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023621">
        <property type="entry name" value="Ribosomal_eL31_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10956:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01198">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01380">
        <property type="entry name" value="Ribosomal_L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54575">
        <property type="entry name" value="Ribosomal protein L31e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="115" mass="13093" checksum="8740AD2520D4A20F" modified="2005-04-12" version="1">MAQGNKGSMAPCTRDYTINLSKMVHKISFKKRAPRAIKGIREFAGKVMKTEDVRIDAKLNKFIFSKGVRNLPTRVRVRISRKRSESEDSKDSLYTLVQYIPVATFAGLQTEKVQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR74</accession>
    <name>Q5CR74_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="6">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd4_1840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="6">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625778.1">
        <property type="nucleotide sequence ID" value="XM_625778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR74"/>
    <dbReference type="FunCoup" id="Q5CR74">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR74"/>
    <dbReference type="GeneID" id="3372764"/>
    <dbReference type="KEGG" id="cpv:cgd4_1840"/>
    <dbReference type="InParanoid" id="Q5CR74"/>
    <dbReference type="OMA" id="AVHIKAD"/>
    <dbReference type="OrthoDB" id="422663at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17949">
        <property type="entry name" value="DEADc_DDX31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="70"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="486"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="838" mass="95912" checksum="F64049D24EC5F2E5" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR90</accession>
    <name>Q5CR90_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625762.1">
        <property type="nucleotide sequence ID" value="XM_625762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR90"/>
    <dbReference type="GeneID" id="3372924"/>
    <dbReference type="KEGG" id="cpv:cgd4_1670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1670"/>
    <dbReference type="InParanoid" id="Q5CR90"/>
    <dbReference type="OrthoDB" id="344307at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="199" mass="19213" checksum="34860C8E63A079FC" modified="2005-04-12" version="1">MPFLNRSLKKPYNSVFLLITLCLLIITRNSECVRYKERLKEGGLGNFLLGLAGSAVSTGIQSATGSPLVANPAMTTPGIANPLAGASPAGAAANPMAAASPGAAIAAAPGAVPGATPGAAAGATPGAVAGATPGAPAAVGGMAAQGVGMVPGQGGIPGAMGGAATPSALSFTTIAFGVIVTMMICMVMLMCRRCTKDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR92</accession>
    <name>Q5CR92_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_1640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625760.1">
        <property type="nucleotide sequence ID" value="XM_625760.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372927"/>
    <dbReference type="KEGG" id="cpv:cgd4_1640"/>
    <dbReference type="InParanoid" id="Q5CR92"/>
    <dbReference type="OrthoDB" id="341972at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="unsure residue" description="D or N" evidence="1">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="620" mass="71950" checksum="1E53E6B6C6757C97" modified="2013-05-29" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRD7</accession>
    <name>Q5CRD7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626249.1">
        <property type="nucleotide sequence ID" value="XM_626249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRD7"/>
    <dbReference type="SMR" id="Q5CRD7"/>
    <dbReference type="STRING" id="353152.Q5CRD7"/>
    <dbReference type="GeneID" id="3373042"/>
    <dbReference type="KEGG" id="cpv:cgd5_3210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3210"/>
    <dbReference type="InParanoid" id="Q5CRD7"/>
    <dbReference type="OMA" id="YQRVKEM"/>
    <dbReference type="OrthoDB" id="340283at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254291" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1258" mass="148948" checksum="F302D6FC3249DA6F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRF2</accession>
    <name>Q5CRF2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_3020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626234.1">
        <property type="nucleotide sequence ID" value="XM_626234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRF2"/>
    <dbReference type="GeneID" id="3373247"/>
    <dbReference type="KEGG" id="cpv:cgd5_3020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3020"/>
    <dbReference type="InParanoid" id="Q5CRF2"/>
    <dbReference type="OMA" id="DSENDHY"/>
    <dbReference type="OrthoDB" id="339709at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="838" mass="98383" checksum="F8C3DF952607FAC6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRF5</accession>
    <name>Q5CRF5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">U5snrp Brr2 SFII RNA helicase (sec63 and the second part of the RNA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd5_2960</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626231.1">
        <property type="nucleotide sequence ID" value="XM_626231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRF5"/>
    <dbReference type="FunCoup" id="Q5CRF5">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRF5"/>
    <dbReference type="GeneID" id="3373245"/>
    <dbReference type="KEGG" id="cpv:cgd5_2960"/>
    <dbReference type="InParanoid" id="Q5CRF5"/>
    <dbReference type="OMA" id="MANETCV"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000012">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041094">
        <property type="entry name" value="Brr2_helicase_PWI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18149">
        <property type="entry name" value="Helicase_PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="537"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="752"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="181"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1204" mass="138410" checksum="8245B9DD338EC60D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRH6</accession>
    <name>Q5CRH6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626210.1">
        <property type="nucleotide sequence ID" value="XM_626210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRH6"/>
    <dbReference type="GeneID" id="3373226"/>
    <dbReference type="KEGG" id="cpv:cgd5_2740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2740"/>
    <dbReference type="InParanoid" id="Q5CRH6"/>
    <dbReference type="OMA" id="HTESICN"/>
    <dbReference type="OrthoDB" id="338682at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="476"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="512" mass="59827" checksum="15D226AA1AF80D8B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRU8</accession>
    <name>Q5CRU8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626088.1">
        <property type="nucleotide sequence ID" value="XM_626088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRU8"/>
    <dbReference type="STRING" id="353152.Q5CRU8"/>
    <dbReference type="GeneID" id="3373286"/>
    <dbReference type="KEGG" id="cpv:cgd5_1410"/>
    <dbReference type="InParanoid" id="Q5CRU8"/>
    <dbReference type="OMA" id="NINFNCY"/>
    <dbReference type="OrthoDB" id="205993at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006994">
        <property type="entry name" value="TCF25/Rqc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684">
        <property type="entry name" value="NULP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22684:SF0">
        <property type="entry name" value="RIBOSOME QUALITY CONTROL COMPLEX SUBUNIT TCF25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04910">
        <property type="entry name" value="Tcf25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="658" mass="77078" checksum="4C06429FD7BE420F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRW1</accession>
    <name>Q5CRW1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd5_1260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626075.1">
        <property type="nucleotide sequence ID" value="XM_626075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRW1"/>
    <dbReference type="STRING" id="353152.Q5CRW1"/>
    <dbReference type="GeneID" id="3373095"/>
    <dbReference type="KEGG" id="cpv:cgd5_1260"/>
    <dbReference type="InParanoid" id="Q5CRW1"/>
    <dbReference type="OMA" id="VCVVMTW"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="99"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="305" mass="35943" checksum="C619E2A8261B3E46" modified="2005-04-12" version="1" fragment="single">YLYRINQMLVKSILKQSPSLFIFITLVLINCYTIFNFIACLKVYQSSLLYYLWSGILTWYTILTLLTIYSFAILIIKDPGSLESLKCDNNPPREFKSTIRYCNKCSGRKWKPPRAHHCTTCNICIFKMDHHCMLINNCIGYSNQKIYILFLFYLACSSSLTIVSSFFLLTKLIIFSLENGIKEMRQALIINLIIHIIIFLTTVIFLFDQIDYISSNSTLVESMTNKRGKKIKLFNNFKMIFGESKYLWFLPLRNIIRPNFNEELYEIIEYPNYTHFSEIRFADNNEQLKSFCELSKINKKISKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSB5</accession>
    <name>Q5CSB5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Phosphatidylinositol-glycan-class c, pigC, 8x transmembrane domains</fullName>
            <ecNumber evidence="9">3.5.1.89</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd1_3380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="9"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628152.1">
        <property type="nucleotide sequence ID" value="XM_628152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSB5"/>
    <dbReference type="FunCoup" id="Q5CSB5">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSB5"/>
    <dbReference type="GeneID" id="3371587"/>
    <dbReference type="KEGG" id="cpv:cgd1_3380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3380"/>
    <dbReference type="InParanoid" id="Q5CSB5"/>
    <dbReference type="OMA" id="QIFVLWL"/>
    <dbReference type="OrthoDB" id="417678at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009450">
        <property type="entry name" value="Plno_GlcNAc_GPI2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN, CLASS C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12982:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06432">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016104">
        <property type="entry name" value="GPI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="47"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="213"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="274" mass="31866" checksum="DB8702B5C6472A4D" modified="2005-04-12" version="1">MVHKVLYREFQEGSPNDISIDDNDNYEEYLKYNVTHITSIQHNYYDILIRLIGVLQVLGLLIQTILIWYNLYIGFLSFEFLALLDLSLLSIMYIFISPNVNLLVIFGFLWLVSPILITLTASFSDDTIIALCTIAFLLYLLSHDYTIIYKDLKEIEHQNTDVVALNLSMLGSILLASRLENNIQVYFFLCFSIHILYFSRMVRHNLWNNLPKVYLYVLTPITSITPIWFLYYPLNIVYTIICAVIISGTILYVYCGSNYKNVIFGPWDVATINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSC1</accession>
    <name>Q5CSC1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ring domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_3320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628146.1">
        <property type="nucleotide sequence ID" value="XM_628146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSC1"/>
    <dbReference type="STRING" id="353152.Q5CSC1"/>
    <dbReference type="GeneID" id="3371453"/>
    <dbReference type="KEGG" id="cpv:cgd1_3320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3320"/>
    <dbReference type="InParanoid" id="Q5CSC1"/>
    <dbReference type="OMA" id="EHITCEI"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000033">
        <property type="entry name" value="Polycomb group RING finger protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051507">
        <property type="entry name" value="PcG_RING_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45893">
        <property type="entry name" value="POLYCOMB GROUP RING FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="47"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="284" mass="32893" checksum="F723062337588E2E" modified="2005-04-12" version="1">MNFSRNRKGVKDDSKYIYEPGDLETKVTENGLDVSFKRKVVSDLLICPICEGFFRGATTIRECLHTFCKACIIEHIESKGAECPKCGQNIGIYPLQGLVFDRTIQNITDKIFPEFKDKERKLYTEFLEKYGDEADIHDEKDLMSLTKPITSQLLNKIKLKPIDSTANFYNEILLPELEKNKTVDSNNQTTTVLENLSMKIKLESINSEFFQLEKPYLIVPPQITIFHLQNYIMHKSNEKFEKIPSIFLKGGQILPRNHSLEFVCRSRRIPLDNLLILEFGIQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSG4</accession>
    <name>Q5CSG4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA:m(4)X modification enzyme TRM13</fullName>
            <ecNumber evidence="1">2.1.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_2810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>adenosine(4) in tRNA(His) + S-adenosyl-L-methionine = 2'-O-methyladenosine(4) in tRNA(His) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43196"/>
            <dbReference type="Rhea" id="RHEA-COMP:10401"/>
            <dbReference type="Rhea" id="RHEA-COMP:10402"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74477"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Gly)(GCC) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43192"/>
            <dbReference type="Rhea" id="RHEA-COMP:10399"/>
            <dbReference type="Rhea" id="RHEA-COMP:10400"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>cytidine(4) in tRNA(Pro) + S-adenosyl-L-methionine = 2'-O-methylcytidine(4) in tRNA(Pro) + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32767"/>
            <dbReference type="Rhea" id="RHEA-COMP:10397"/>
            <dbReference type="Rhea" id="RHEA-COMP:10398"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.225"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase TRM13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.225" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628103.1">
        <property type="nucleotide sequence ID" value="XM_628103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSG4"/>
    <dbReference type="STRING" id="353152.Q5CSG4"/>
    <dbReference type="GeneID" id="3371482"/>
    <dbReference type="KEGG" id="cpv:cgd1_2810"/>
    <dbReference type="InParanoid" id="Q5CSG4"/>
    <dbReference type="OMA" id="FISSWAT"/>
    <dbReference type="OrthoDB" id="258806at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106050">
        <property type="term" value="F:tRNA 2'-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007871">
        <property type="entry name" value="Methyltransferase_TRM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039044">
        <property type="entry name" value="Trm13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021721">
        <property type="entry name" value="Znf_CCCH-type_TRM13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12998:SF0">
        <property type="entry name" value="TRNA:M(4)X MODIFICATION ENZYME TRM13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05206">
        <property type="entry name" value="TRM13"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11722">
        <property type="entry name" value="zf-TRM13_CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger CCCH-type TRM13" evidence="3">
        <location>
            <begin position="7"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase TRM13" evidence="2">
        <location>
            <begin position="196"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="domain" description="Methyltransferase TRM13" evidence="2">
        <location>
            <begin position="370"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="485" mass="55806" checksum="149D56E0993183FE" modified="2005-04-12" version="1">MEIQVQTCTFFIKSKSRNCKFPRYGDSNFCNLHKGIQDQVCDENHEKLVNKIIPCFIDGRHFVSINKIRSHIRKCSRVRDIAYELNQPFCMHNNGPPHNLLNIREKLQVTETSHIEEINRKANKNNHSDSKKKLIVSKERLEFVDKLHDFCVREFGKNPHFESRQVDIDNLNLNRHELQAISISKEFTKRLINSENSISCNNSNNNLLFDAENSLIIEYGAGNAILSYWFIKECGKPQNKIKPSKFRSVIIDRESRRKQMEKLDESISSIRLRLDIEQFDINSLILVCNNEDISKESIRAHMYSSLGNGNVPWIISTLLEQKIWMHDSSGKQIQTIEEVEQLSKEELKYILTTLSNGGGPDISRLEETIINNFAKKKILKIFVISKHLCGNGFDLGLKSSQSAIKEMKSGSMLIIIMSPCCHHRCLISQHLGAEMLNQIATQEGLFDNTEECFNFLASISSWSTGTSDYRSNYGFKAKYILDSCR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSH9</accession>
    <name>Q5CSH9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Calcium antiporter, Na/Ca exchange associated membrane protein with 11 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd1_2620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628088.1">
        <property type="nucleotide sequence ID" value="XM_628088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSH9"/>
    <dbReference type="FunCoup" id="Q5CSH9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSH9"/>
    <dbReference type="GeneID" id="3371689"/>
    <dbReference type="KEGG" id="cpv:cgd1_2620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2620"/>
    <dbReference type="InParanoid" id="Q5CSH9"/>
    <dbReference type="OMA" id="AVMITCN"/>
    <dbReference type="OrthoDB" id="1699231at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015369">
        <property type="term" value="F:calcium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004713">
        <property type="entry name" value="CaH_exchang"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31503:SF22">
        <property type="entry name" value="VACUOLAR CALCIUM ION TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="231"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="323"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="392"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="427"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="453"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="100"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="328"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="473" mass="52747" checksum="D41A9F71A9707BE2" modified="2005-04-12" version="1">MVLQRMRATSYLRRTMSDPFSRRRTTLPYIVGIFSQKNDLCKNLMNTGISKNSFKETKIPNYTWKSDAIAVLDIFFTKLNILFLFVPFGVLSYYLEWGALATFWFNFIALIPLANLLGIFTEELALHTGEVVGGLLNATFGNAVEAILTVQGIRAGLITVVQGTLLGSILSNLLLVLGMSFFAGGIFHHVQKFNEKGASFSTSLLMLSCMAISIPTIVAQFDLPQHNILMISRLTAILLSFTYVLFLFFQLYTHINLFRDESVASNDKSYPSYMIDNISSVKYPNALPNIEIYNNNIYKNYPIISQNFNNYQLYDVCLELPTISWQIGTVLILLCTILISIISECLVDSINGFISEWRFSENFIGVILLPLVGNAAEHITAVSVAIKNKTDLTIGVAIGSSTQIALFVVPFSVIVGWLLGKPMTLSFTPVSAIILLLTNLIVIGIVQDGESNWFEGILLIISYCIVAVVYWYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSW6</accession>
    <name>Q5CSW6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_1060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627951.1">
        <property type="nucleotide sequence ID" value="XM_627951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSW6"/>
    <dbReference type="GeneID" id="3371552"/>
    <dbReference type="KEGG" id="cpv:cgd1_1060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1060"/>
    <dbReference type="InParanoid" id="Q5CSW6"/>
    <dbReference type="OMA" id="CHTIVAS"/>
    <dbReference type="OrthoDB" id="338575at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="662"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="921"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="633"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="929"/>
            <end position="943"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1055" mass="122041" checksum="F1D1C703F4C7F42F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSX8</accession>
    <name>Q5CSX8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">U2 snrnp-specific A' protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the ANP32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627939.1">
        <property type="nucleotide sequence ID" value="XM_627939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSX8"/>
    <dbReference type="FunCoup" id="Q5CSX8">
        <property type="interactions" value="145"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSX8"/>
    <dbReference type="GeneID" id="3371562"/>
    <dbReference type="KEGG" id="cpv:cgd1_930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_930"/>
    <dbReference type="InParanoid" id="Q5CSX8"/>
    <dbReference type="OMA" id="VTNENAY"/>
    <dbReference type="OrthoDB" id="2160613at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045081">
        <property type="entry name" value="AN32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11375:SF0">
        <property type="entry name" value="ACIDIC LEUCINE-RICH NUCLEAR PHOSPHOPROTEIN 32 FAMILY MEMBER A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="193"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="238"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="299" mass="34372" checksum="10AAFFF0C939BFAE" modified="2005-04-12" version="1">MEASIRNRLRKQDLVLPDEEVPNSQDSNINSIDYSEVKELVLDGVKLRELTQQDSEFLGRFSELQYLSLNATGLQRLDNFPLLENLKVLEIQDNHISGGLDILQNYKNLRCLLLGGNKIKDFSELIVLKELPKLETLSLLLNPIAEKNSESYRSIVFETLPNLQILDEMNKEGKEVEDYGYDDEEVEIIDDDTEGGDEEETSVHADSHGLPDDDDDDDFDDDDDEDAGQVDLKQFYENDLEDDDDEDEFEPGDVDIDEAEDFEEEEEEDDEEDEEDEIQASSSKKQRIEQDDDDDDEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSY6</accession>
    <name>Q5CSY6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Palmitoyltransferase</fullName>
            <ecNumber evidence="8">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_820</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="8">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627931.1">
        <property type="nucleotide sequence ID" value="XM_627931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSY6"/>
    <dbReference type="SMR" id="Q5CSY6"/>
    <dbReference type="STRING" id="353152.Q5CSY6"/>
    <dbReference type="GeneID" id="3371566"/>
    <dbReference type="KEGG" id="cpv:cgd1_820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_820"/>
    <dbReference type="InParanoid" id="Q5CSY6"/>
    <dbReference type="OMA" id="YYYVFLY"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24161:SF124">
        <property type="entry name" value="TRANSIENT RECEPTOR POTENTIAL CHANNEL PYREXIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="271"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="508"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="586"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="7">
        <location>
            <begin position="156"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="9">
        <location>
            <begin position="464"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="764" mass="89174" checksum="BAE34EEC886B74BE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT40</accession>
    <name>Q5CT40_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted secreted protein, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627877.1">
        <property type="nucleotide sequence ID" value="XM_627877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT40"/>
    <dbReference type="STRING" id="353152.Q5CT40"/>
    <dbReference type="GeneID" id="3371422"/>
    <dbReference type="KEGG" id="cpv:cgd1_150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_150"/>
    <dbReference type="InParanoid" id="Q5CT40"/>
    <dbReference type="OMA" id="NDSENCT"/>
    <dbReference type="OrthoDB" id="343946at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253814" evidence="3">
        <location>
            <begin position="25"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="689"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="757"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="480"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="622"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="636"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="832"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="995" mass="115445" checksum="1BB41F84C1DB4ED5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT43</accession>
    <name>Q5CT43_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide, predicted secreted protein with a cysteine cluster at the C-terminus, paralogs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627874.1">
        <property type="nucleotide sequence ID" value="XM_627874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT43"/>
    <dbReference type="STRING" id="353152.Q5CT43"/>
    <dbReference type="GeneID" id="3371436"/>
    <dbReference type="KEGG" id="cpv:cgd1_120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_120"/>
    <dbReference type="InParanoid" id="Q5CT43"/>
    <dbReference type="OrthoDB" id="344287at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254940" evidence="2">
        <location>
            <begin position="23"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="431" mass="48274" checksum="FB28CFA92AB5FD7E" modified="2005-04-12" version="1">MLKLSFCLAILIICFCINYSFGASNQSKSGEERFKNSALYQATALKNFWALLKLMVNLTECSNHYNIDRMLFCSPSIGYYLEMTQKSLIEKSKQLSEKEKEIIAGASCSPDLKDQFEKLNEIINECLKRRLKTEAAVTLKDELLELIKTIYCQMAYFGFSSLIPNHTDEDALHLFQEFSSASGFTVTKLVLANTSKTSNENNTVKVNHRKSKRNNQYSAPKQLSQHELLEATKAADLSAHLMLGCCTDGTCGALEGKAKSKAKSKKKSGGRKKLKEIALDVPNIEEKSNEIDHENSDEDLVQSIEIVNQIICSLGLIAEIEEKLISRENSFETIMKKIFDIDSAILDKGLKERVAKLPVNMKIQSSSIKNLLALKSGYKENIKKMAKTSIDGNGENLTINLLCNQKPNGKCVHCSHCNSKLSEDDEIYFVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT46</accession>
    <name>Q5CT46_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Predicted transcription factor subunit TAF6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_90</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627871.1">
        <property type="nucleotide sequence ID" value="XM_627871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT46"/>
    <dbReference type="GeneID" id="3371432"/>
    <dbReference type="KEGG" id="cpv:cgd1_90"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_90"/>
    <dbReference type="InParanoid" id="Q5CT46"/>
    <dbReference type="OMA" id="IMEIVEF"/>
    <dbReference type="OrthoDB" id="341636at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046695">
        <property type="term" value="C:SLIK (SAGA-like) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22931">
        <property type="entry name" value="HFD_TAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.770">
        <property type="entry name" value="TAF6, C-terminal HEAT repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037796">
        <property type="entry name" value="TAF6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011442">
        <property type="entry name" value="TAF6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046344">
        <property type="entry name" value="TAF6_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10221:SF9">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07571">
        <property type="entry name" value="TAF6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAF6 C-terminal HEAT repeat" evidence="6">
        <location>
            <begin position="405"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF07571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="757" mass="87908" checksum="7DB417A98457A0E2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT67</accession>
    <name>Q5CT67_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_4230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626602.1">
        <property type="nucleotide sequence ID" value="XM_626602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT67"/>
    <dbReference type="GeneID" id="3373482"/>
    <dbReference type="KEGG" id="cpv:cgd2_4230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4230"/>
    <dbReference type="InParanoid" id="Q5CT67"/>
    <dbReference type="OrthoDB" id="342284at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="148" mass="17426" checksum="450FD2BC92AB7903" modified="2005-04-12" version="1">MEKLKLVVPIRRQENSAFKHIHNYDPEKVEKIKVKDDINRLSCVKELANIGNDLNDLVKKIKIRRYIGLMYQITILKIHLSRLLGKVRNKKKVKVLNFHMVQRHSHKKTDIHFGSAQNQNSPPKSPNRMDLKMLPRKLNNQYFHEGGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTL3</accession>
    <name>Q5CTL3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutaredoxin related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_2540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626456.1">
        <property type="nucleotide sequence ID" value="XM_626456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTL3"/>
    <dbReference type="FunCoup" id="Q5CTL3">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTL3"/>
    <dbReference type="GeneID" id="3373669"/>
    <dbReference type="KEGG" id="cpv:cgd2_2540"/>
    <dbReference type="InParanoid" id="Q5CTL3"/>
    <dbReference type="OMA" id="YCHKARA"/>
    <dbReference type="OrthoDB" id="44061at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015038">
        <property type="term" value="F:glutathione disulfide oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03419">
        <property type="entry name" value="GRX_GRXh_1_2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014025">
        <property type="entry name" value="Glutaredoxin_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694">
        <property type="entry name" value="GLUTAREDOXIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45694:SF18">
        <property type="entry name" value="GLUTAREDOXIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00160">
        <property type="entry name" value="GLUTAREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="1">
        <location>
            <begin position="26"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="108" mass="11779" checksum="CA5BBE3A8542DD87" modified="2005-04-12" version="1" fragment="single">LKNIDTAMNSIKLLVESFISSGDICVISKSYCPYCIKAINSLKSAGYSPLVMQIDGRVDTKEIQDYCRELTGSGTVPRVFVKGRFIGGCDDTLKLLEDGSLSSFVETI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTL9</accession>
    <name>Q5CTL9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Methionine aminopeptidase 2</fullName>
            <shortName evidence="8">MAP 2</shortName>
            <shortName evidence="8">MetAP 2</shortName>
            <ecNumber evidence="8">3.4.11.18</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Peptidase M</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd2_2480</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 8 9">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626450.1">
        <property type="nucleotide sequence ID" value="XM_626450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTL9"/>
    <dbReference type="FunCoup" id="Q5CTL9">
        <property type="interactions" value="536"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTL9"/>
    <dbReference type="MEROPS" id="M24.002"/>
    <dbReference type="GeneID" id="3373496"/>
    <dbReference type="KEGG" id="cpv:cgd2_2480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2480"/>
    <dbReference type="InParanoid" id="Q5CTL9"/>
    <dbReference type="OMA" id="PFAKRWL"/>
    <dbReference type="OrthoDB" id="7848262at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01088">
        <property type="entry name" value="MetAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03175">
        <property type="entry name" value="MetAP_2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050247">
        <property type="entry name" value="Met_Aminopeptidase_Type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002468">
        <property type="entry name" value="Pept_M24A_MAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018349">
        <property type="entry name" value="Pept_M24A_MAP2_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00501">
        <property type="entry name" value="met_pdase_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45777:SF2">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01202">
        <property type="entry name" value="MAP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="11">
        <location>
            <begin position="159"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="53"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="242"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="253"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="322"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="453"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="472" mass="53706" checksum="7D4A94ECCB570F1C" modified="2005-04-12" version="1">MSENEYNEKDNQNNGKELGTKTEQKTQLLLEESGVLNLDKPLNEIESIDNKQNNKKKKKKKKKKGKENLYEDKDDTYDPDLPTYSIPIQDNTHLRKVCNWPAIEFSKQTSPPTVPINKIYSRHEFPEGEIIEYNGPNSYRISSEELKDKEKLHILDYASLRRAAEVHRQVRKYMQSIIRPEMKLIDMCNILESKVKELVAAEGLKCGWGFPTGCSLNHCAAHYTPNPHDFTKLTQDDICKLDFGVQVNGMIIDCAFTVAFNDVFDPLIQSTLDATNTGLKVAGIDVMFSEIGSAIEEVIKSYEFEYKSKVYNIKPIKNLNGHSILPYHIHGGKSVPIIATNDDTRMEENEIYAIETFATTGRGYVTEGLDCSHYMKYYDNPFLNENSTRLNSAKILLGGINTHFGTLAFCRRWLDQLGFNKHALALKSLVDSEIIRPYPPLNDIPGSFSSQMEHTILLRPSCKEVVSRGDDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTN1</accession>
    <name>Q5CTN1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">R1 like alpha-glucan water dikinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_2340</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PEP-utilizing enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626438.1">
        <property type="nucleotide sequence ID" value="XM_626438.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTN1"/>
    <dbReference type="GeneID" id="3373510"/>
    <dbReference type="KEGG" id="cpv:cgd2_2340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2340"/>
    <dbReference type="InParanoid" id="Q5CTN1"/>
    <dbReference type="OMA" id="HRYNLMR"/>
    <dbReference type="OrthoDB" id="6123450at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054481">
        <property type="entry name" value="GWD1_pHisD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002192">
        <property type="entry name" value="PPDK_AMP/ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46999:SF1">
        <property type="entry name" value="ALPHA-GLUCAN WATER DIKINASE 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46999">
        <property type="entry name" value="ALPHA-GLUCAN WATER DIKINASE 1, CHLOROPLASTIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22973">
        <property type="entry name" value="GWD1_pHisD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01326">
        <property type="entry name" value="PPDK_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Alpha-glucan water dikinase phosphohistidine-like" evidence="12">
        <location>
            <begin position="1129"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate phosphate dikinase AMP/ATP-binding" evidence="11">
        <location>
            <begin position="1410"/>
            <end position="1651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1652" mass="192829" checksum="B9A2B243C0F995E8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU14</accession>
    <name>Q5CU14_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PMS1'MutL family ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_700</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626305.1">
        <property type="nucleotide sequence ID" value="XM_626305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU14"/>
    <dbReference type="FunCoup" id="Q5CU14">
        <property type="interactions" value="405"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU14"/>
    <dbReference type="GeneID" id="3373654"/>
    <dbReference type="KEGG" id="cpv:cgd2_700"/>
    <dbReference type="InParanoid" id="Q5CU14"/>
    <dbReference type="OMA" id="MRPRRMP"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1540.20">
        <property type="entry name" value="MutL, C-terminal domain, dimerisation subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.100">
        <property type="entry name" value="MutL, C-terminal domain, regulatory subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014790">
        <property type="entry name" value="MutL_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042120">
        <property type="entry name" value="MutL_C_dimsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042121">
        <property type="entry name" value="MutL_C_regsub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037198">
        <property type="entry name" value="MutL_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF52">
        <property type="entry name" value="MISMATCH REPAIR ENDONUCLEASE PMS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08676">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00853">
        <property type="entry name" value="MutL_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118116">
        <property type="entry name" value="DNA mismatch repair protein MutL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="5">
        <location>
            <begin position="268"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="MutL C-terminal dimerisation" evidence="4">
        <location>
            <begin position="736"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="435"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="475"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="574"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="913"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="435"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="447"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="583"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="918"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="937"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="971" mass="111808" checksum="CFA9871F0A4C9E16" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU63</accession>
    <name>Q5CU63_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexose transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd3_4070</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-fructose(out) = D-fructose(in)</text>
            <dbReference type="Rhea" id="RHEA:60372"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:60373"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-galactose(in) = D-galactose(out)</text>
            <dbReference type="Rhea" id="RHEA:34915"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:34917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucosamine(out) = D-glucosamine(in)</text>
            <dbReference type="Rhea" id="RHEA:78423"/>
            <dbReference type="ChEBI" id="CHEBI:58723"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:78424"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:60377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-mannose(out) = D-mannose(in)</text>
            <dbReference type="Rhea" id="RHEA:78391"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:78392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-xylose(out) = D-xylose(in)</text>
            <dbReference type="Rhea" id="RHEA:78427"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:78428"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626951.1">
        <property type="nucleotide sequence ID" value="XM_626951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU63"/>
    <dbReference type="STRING" id="353152.Q5CU63"/>
    <dbReference type="GeneID" id="3374010"/>
    <dbReference type="KEGG" id="cpv:cgd3_4070"/>
    <dbReference type="InParanoid" id="Q5CU63"/>
    <dbReference type="OMA" id="FMQTFAP"/>
    <dbReference type="OrthoDB" id="6612291at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005351">
        <property type="term" value="F:carbohydrate:proton symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050360">
        <property type="entry name" value="MFS_Sugar_Transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48022:SF2">
        <property type="entry name" value="PLASTIDIC GLUCOSE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 14 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="16" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="96"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="120"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="154"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="190"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="281"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="385"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="421"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="15">
        <location>
            <begin position="17"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK89236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="488" mass="53902" checksum="0D3309A8D6E9A39D" modified="2005-04-12" version="1" fragment="single">YIGSIYTAEMANYSLNCCLIALSVSLLFGINLSILNFTGPYVLLDYELCGKEGTLLERSNCENGSYAMYKMTLAFFTASLLSCFAVKYVVGRSRTFGLKVALIPFAVGGILSSFAPNFKIFCIGRFISGASLGLSAASVTYISEISPKHRRGLYTTLFGLFIPAGQTISYILGVFLPIIKYLDESDLEFYILYCRFLFLIPTIISLIMIIAVRFYCKDETPCFLLSKGRFSEAEELLYKIYQDTSVVSSEMESLLTSNRRSIEEDKISQNVSYSMLFSRKYILPTFVTLVITVGVSGSGIGIFAQKMNSLIESASGLPQEKVIYIVIFTSAFETVSCFFGGHLIEKFGRRNVAIIGSATNSLSLLLLGLFTIFKNYISSVVIPVVSIIVFSTFLASFQLALSPVLWAYVPEALPTEIRSTGMGLSSILNWLVSLIYIPLSYIISDLSVYALSSICCGILSIICFFFMKETKGCSVSPYEEDSVKNPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUA3</accession>
    <name>Q5CUA3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_3620</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626911.1">
        <property type="nucleotide sequence ID" value="XM_626911.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CUA3">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="GeneID" id="3373937"/>
    <dbReference type="KEGG" id="cpv:cgd3_3620"/>
    <dbReference type="InParanoid" id="Q5CUA3"/>
    <dbReference type="OMA" id="RDYKMKN"/>
    <dbReference type="OrthoDB" id="343843at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090324">
        <property type="term" value="P:negative regulation of oxidative phosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022904">
        <property type="term" value="P:respiratory electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052000">
        <property type="entry name" value="ETFRF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024:SF0">
        <property type="entry name" value="ELECTRON TRANSFER FLAVOPROTEIN REGULATORY FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21024">
        <property type="entry name" value="GROWTH HORMONE-INDUCIBLE SOLUBLE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1032"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1177"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1210"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="173"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="852"/>
            <end position="916"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1091"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="863"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1581" mass="186475" checksum="A5E76A586FA7ABA4" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUE6</accession>
    <name>Q5CUE6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Rab5 like small GTpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_3150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626868.1">
        <property type="nucleotide sequence ID" value="XM_626868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUE6"/>
    <dbReference type="FunCoup" id="Q5CUE6">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUE6"/>
    <dbReference type="GeneID" id="3373880"/>
    <dbReference type="KEGG" id="cpv:cgd3_3150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3150"/>
    <dbReference type="InParanoid" id="Q5CUE6"/>
    <dbReference type="OMA" id="DEEGLMW"/>
    <dbReference type="OrthoDB" id="63533at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01860">
        <property type="entry name" value="Rab5_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000823">
        <property type="entry name" value="Small GTPase RAB, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47978">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="179"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="183"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="218" mass="24206" checksum="ABE5D4ED4AF33963" modified="2005-04-12" version="1">MSQTAIKTPKTLHLKLVLLGDASVGKSCLVVRFSKDEFHEYQEPTIGAAFMTQSVNVDDDYTVKFEIWDTAGQERYRSLAPMYYRGAAAAIVVYDITNVETFQGAKSWISELQNINNNDIVVALVGNKYDLESSRTVDSETARNYAKEKGILSFETSAKTGYNVQELFEEIARKLPNTKKLDSNSMSTENNGKTGGFQLFRSDRRGGGNCFSNGCSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUN9</accession>
    <name>Q5CUN9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd3_2060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626775.1">
        <property type="nucleotide sequence ID" value="XM_626775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUN9"/>
    <dbReference type="STRING" id="353152.Q5CUN9"/>
    <dbReference type="GeneID" id="3373787"/>
    <dbReference type="KEGG" id="cpv:cgd3_2060"/>
    <dbReference type="InParanoid" id="Q5CUN9"/>
    <dbReference type="OMA" id="TICENQS"/>
    <dbReference type="OrthoDB" id="421575at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039525">
        <property type="entry name" value="RNF126-like_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PRAJA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15710:SF217">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RDUF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14369">
        <property type="entry name" value="Zn_ribbon_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="251"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="376"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="493" mass="54064" checksum="55201B0820F5AA82" modified="2005-04-12" version="1" fragment="single">TKIHNIESNGALGHVSGSNSNSNRYFCHACQNNVTICENQSDNTDLTCPQCGNNGFVELISFGSQQSQGVSLLGITEPINPQEASTNLPRSSWIDISSFPQSGTEIGPENILSRLISEVSNSLRNSSNNPTSFDPLLPNYNTRIHQEQHNSHHAHAVSFSSELPTGNPGATTFMVGLSGEFREFPLGDVLTGSTLSNLVESMENALAVALSTEDPNNRFGSPPASTQVVEQLPRETVTEDNIVRIKMCGPCVVCQDEYSIGDEVMGLSRDEEVCHHIFHANCLLPWLNQHNSCPVCRFELPTDDEFYESRRRSSAQNISSTLESTNQAGTQVEARNGIQDHLDSATVSNNNIQSTNSESQEPLIEAELGSSQINSQERDQDHARNEGNSNNAASSNFRTINFSNPIGEVTTLTSQLPVITSTISTTETFHTTSNQDPISTDDIINDFHNSTHRRIHQLHHSGIDLTSRDLDPDSISDFTPIDTIRHSNSCRMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUR2</accession>
    <name>Q5CUR2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626752.1">
        <property type="nucleotide sequence ID" value="XM_626752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUR2"/>
    <dbReference type="GeneID" id="3374157"/>
    <dbReference type="KEGG" id="cpv:cgd3_1800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1800"/>
    <dbReference type="InParanoid" id="Q5CUR2"/>
    <dbReference type="OMA" id="VEEYKSH"/>
    <dbReference type="OrthoDB" id="342527at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="22"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="186"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="445"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="533"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="561" mass="64644" checksum="A5C077DFA57FE0FC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUT7</accession>
    <name>Q5CUT7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SDE2-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626727.1">
        <property type="nucleotide sequence ID" value="XM_626727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUT7"/>
    <dbReference type="GeneID" id="3374027"/>
    <dbReference type="KEGG" id="cpv:cgd3_1530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1530"/>
    <dbReference type="InParanoid" id="Q5CUT7"/>
    <dbReference type="OMA" id="FEYEEFD"/>
    <dbReference type="OrthoDB" id="547031at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053822">
        <property type="entry name" value="SDE2-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22782">
        <property type="entry name" value="SDE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SDE2-like" evidence="2">
        <location>
            <begin position="83"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="137"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="204" mass="22757" checksum="43A5BF844D833CC1" modified="2005-04-12" version="1">MKLNFDFQGVFKSINLKENLNFNNCVSAYNNIKSYAANAFKSCEDDISLFLEGKPFVLSNINYNELSNKLIKVRKNIENGLKGGKGGFGATIKSQKRKVNVRELSVDLCRDLKTGKRIKDLNKSGNNVESKVEGSSRTKSSSSTNSGSISRNSKVLENSCSIVNSENELLTQYQSHVLNLENKWKNISKSVDFGMNNLNQKVNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUU4</accession>
    <name>Q5CUU4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Replication factor C like AAA+ ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_1450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626720.1">
        <property type="nucleotide sequence ID" value="XM_626720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUU4"/>
    <dbReference type="FunCoup" id="Q5CUU4">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUU4"/>
    <dbReference type="GeneID" id="3373833"/>
    <dbReference type="KEGG" id="cpv:cgd3_1450"/>
    <dbReference type="InParanoid" id="Q5CUU4"/>
    <dbReference type="OMA" id="SCNYSSQ"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000952">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000012">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001679">
        <property type="entry name" value="PRK00440.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF5">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="48"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="339" mass="38217" checksum="EFE7C3B43FDCB3A6" modified="2005-04-12" version="1" fragment="single">GNKLVKSKQILEMSTQIWIEKYRPKILDEMVGNEEVLTRLKVLAKHGNMPNLLLSGPPGTGKTTSIHCLASEMLGSKYGRAVLELNASDDRGIDVVRDKIKSFAREKIDLPEGRHKIVILDEVDSMTDSAQQALRRLMEVYSESTRFALACNQSTKIIEPIQSRCAIIRYSKLTDAQIRKRLFEIIKMENIPYVDSGIDTLVFTADGDMRIVINNLQATYHGFSMVSRDNVLKVSDIPSPEKIKSILDSCVKCNWRLAHSIVEELFIGGYSPLDIVITMRNVLKRYQLPERAILEYLKEVGRCHFVMLDGCATPLQLDKLLGQLCMISARCGLNSNKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUX0</accession>
    <name>Q5CUX0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626694.1">
        <property type="nucleotide sequence ID" value="XM_626694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUX0"/>
    <dbReference type="GeneID" id="3373991"/>
    <dbReference type="KEGG" id="cpv:cgd3_1160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1160"/>
    <dbReference type="InParanoid" id="Q5CUX0"/>
    <dbReference type="OrthoDB" id="10492742at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="126"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="495" mass="56315" checksum="F320E655EA44B9CE" modified="2005-04-12" version="1">MKRSKFSLLYIILKFFILFIFFVYLKTRHDLIKYDHTLTQNNFKRSHSSKLNQFYQILSISFINNGPTNANGEGAKDISDNESGTSSTSGNPSPNNEFDSDNGKQDKTHSMKICRSSSCPNLGPISSSRSNSSSNHNSNSEIKSRSKSEPWLRSKTKSRSKTRSRSKTRSGSKTRSRSESRSRSGSRSRPITVMKKRSKSDSSVNPKPTTSKPAPLNLEDRIGSSGPLSSKEELGIYCLELSVEEVLKILQSKDTSRLSDVSSFSLSMALDELIFMNSSLYSKLVDLEKAIQREKSKLNPEDRNYERRLSTLKDFTKTESSGIIKQSEQLFKLVQILFEILYSRKIQAFESTTDAIISQNSDPKVITSRRIVFSSELISNLTVLYNMLHCNQSFLSSLLFCRFLQDYIENNRRVNSALTKYMMSLEESNGVIESSSKVNRGRKSKRKTRMKKKASRSKSLLKDPECENQEKKIRKLDSKFRKLFTSSNIGLESIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV00</accession>
    <name>Q5CV00_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626664.1">
        <property type="nucleotide sequence ID" value="XM_626664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV00"/>
    <dbReference type="GeneID" id="3374130"/>
    <dbReference type="KEGG" id="cpv:cgd3_820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_820"/>
    <dbReference type="InParanoid" id="Q5CV00"/>
    <dbReference type="OrthoDB" id="344206at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253879" evidence="2">
        <location>
            <begin position="22"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="142" mass="15459" checksum="58602883CB05132B" modified="2005-04-12" version="1">MKRSFFLSLLVLFISYYQVNSQDAYHPFRSTALELADSKDQSSCNENCIQEKNDRALQEAGSSSNSGTNQGSSNSIGDIVQDNMNNLYKELADHAQEQAKNTWDSLSSGAKAGIIIAIVVVAIIIIAGIIHCLCICKLCCCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV92</accession>
    <name>Q5CV92_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_4950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627377.1">
        <property type="nucleotide sequence ID" value="XM_627377.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV92"/>
    <dbReference type="GeneID" id="3374379"/>
    <dbReference type="KEGG" id="cpv:cgd8_4950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4950"/>
    <dbReference type="InParanoid" id="Q5CV92"/>
    <dbReference type="OMA" id="DQNQNYD"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF108">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="472"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="743"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="224"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1421" mass="165963" checksum="6B5F86A2811182C0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVB0</accession>
    <name>Q5CVB0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_4750</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627359.1">
        <property type="nucleotide sequence ID" value="XM_627359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVB0"/>
    <dbReference type="SMR" id="Q5CVB0"/>
    <dbReference type="FunCoup" id="Q5CVB0">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVB0"/>
    <dbReference type="GeneID" id="3374347"/>
    <dbReference type="KEGG" id="cpv:cgd8_4750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4750"/>
    <dbReference type="InParanoid" id="Q5CVB0"/>
    <dbReference type="OMA" id="IAAETRW"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17963">
        <property type="entry name" value="DEADc_DDX19_DDX25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="144"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="340"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="112"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="518" mass="58633" checksum="0AC1B4631AF9E16F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVD2</accession>
    <name>Q5CVD2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627337.1">
        <property type="nucleotide sequence ID" value="XM_627337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVD2"/>
    <dbReference type="STRING" id="353152.Q5CVD2"/>
    <dbReference type="GeneID" id="3374542"/>
    <dbReference type="KEGG" id="cpv:cgd8_4510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4510"/>
    <dbReference type="InParanoid" id="Q5CVD2"/>
    <dbReference type="OMA" id="VMANTQS"/>
    <dbReference type="OrthoDB" id="365880at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="388"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="840"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="903"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="246"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="352"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="392"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="923"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="969"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1078"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1078" mass="112086" checksum="D5EC49AE7B82EE51" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVF7</accession>
    <name>Q5CVF7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">HMG box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_4220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627312.1">
        <property type="nucleotide sequence ID" value="XM_627312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVF7"/>
    <dbReference type="STRING" id="353152.Q5CVF7"/>
    <dbReference type="GeneID" id="3374547"/>
    <dbReference type="KEGG" id="cpv:cgd8_4220"/>
    <dbReference type="InParanoid" id="Q5CVF7"/>
    <dbReference type="OMA" id="DIICEIA"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00084">
        <property type="entry name" value="HMG-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="129"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="129"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="25"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="194"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="195"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="230" mass="25668" checksum="7349256F9BF80552" modified="2005-04-12" version="1">MSVLPPQLGSALQLGAVMQANANNASPGLVTHRTPSHSVPGGQSPTVSQTHNISQQSSSSILVPQAHFESNSSSNLLVDILCEVADFSVDLALRLSQRTGTQWRPKILNHNKHLKRPITRQPLEDPNKPKRPHNAYTLWCEHIRQKVREKDPTRSLHIKDLAEMWKNLPELERSPWERKAQDVKQKYLVDMAAYRTTSGSPGHPQASSGTPPPNSMQQLSGIPNQREFYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVI7</accession>
    <name>Q5CVI7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd8_3900</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DECD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627282.1">
        <property type="nucleotide sequence ID" value="XM_627282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVI7"/>
    <dbReference type="FunCoup" id="Q5CVI7">
        <property type="interactions" value="524"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVI7"/>
    <dbReference type="GeneID" id="3374611"/>
    <dbReference type="KEGG" id="cpv:cgd8_3900"/>
    <dbReference type="InParanoid" id="Q5CVI7"/>
    <dbReference type="OMA" id="YAHVEPK"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17950">
        <property type="entry name" value="DEADc_DDX39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000809">
        <property type="entry name" value="ATP-dependent RNA helicase SUB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000111">
        <property type="entry name" value="DEAD-box ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="78"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="281"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="10">
        <location>
            <begin position="47"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK89721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="430" mass="48957" checksum="E04FA9A62819034D" modified="2005-04-12" version="1" fragment="single">VVRMSVQNTEELVDYEEEETTTRIEEESRADEGSKVGRGNYVAIHASGFRDFFLKPELIRAIGDAGFEHPSEVQHETIPHAITGVDILCQAKSGMGKTAVFVLSILQQLNPDEESKNVECICIGHTRELAFQVKNEFDRFSKYLKNVKPQVVYGGIPIQKDIDMLSNSTPNILIGTPGRIIALIRQKKLVTEGIAHFVLDECDKCLESLDMRKDVQEIFMSTPRKKQVMMFSATMTKEIRDVCRKFMQNPVEIFVDDETKLTLHGLLQYYVKLGESEKNRKLNDLLDQLEFNQVIIFVKSVSRAQALHKLLTECSFPSICIHAALSQQERISRYQQFKNFEKRIMVATDLFGRGIDIERVNIVINYDMPENTDSYLHRVGRAGRFGTKGLAITMVSSQTDSQVLNDVQSRFEVNIAEMPNQIDTSSYINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVM7</accession>
    <name>Q5CVM7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627242.1">
        <property type="nucleotide sequence ID" value="XM_627242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVM7"/>
    <dbReference type="GeneID" id="3374287"/>
    <dbReference type="KEGG" id="cpv:cgd8_3490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3490"/>
    <dbReference type="InParanoid" id="Q5CVM7"/>
    <dbReference type="OMA" id="SISIKIC"/>
    <dbReference type="OrthoDB" id="342647at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="272"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="319" mass="37455" checksum="F741ADEFD70C5C54" modified="2005-04-12" version="1">MQGYSGLSFGINDVKKVPISQANPVQLSNILLNLRYKAFSELSSKVYSYQSDYQYQYKYYLAKLSRYEALEHSITLKLCSMLPEVRRRIDLGSSLILQNYSDEEIYYSHYPVPHNIFMDEVPIFKEFTFFLSLRRSLLELRKKIWRLYSIIETKSSVIKLWEIEYQEAIQEKAENEYIYNLTSNDFGRNIKDYAEKLKQKRFAEFRRAKEMIVLNNLDNGNNEELEKKYSDDEKDRIRKDDGCLILPISKRRVSLHCSIKSESPNMAYRQRIDNKNPSKKGNLKGGDAKYNKMNSVIPDSNVIKKELNKLPPKPEGTGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVP6</accession>
    <name>Q5CVP6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNAJ'DNAJ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627223.1">
        <property type="nucleotide sequence ID" value="XM_627223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVP6"/>
    <dbReference type="FunCoup" id="Q5CVP6">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVP6"/>
    <dbReference type="GeneID" id="3374249"/>
    <dbReference type="KEGG" id="cpv:cgd8_3270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3270"/>
    <dbReference type="InParanoid" id="Q5CVP6"/>
    <dbReference type="OMA" id="TRKPKHA"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026894">
        <property type="entry name" value="DnaJ_X"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052423">
        <property type="entry name" value="EMIR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44094:SF8">
        <property type="entry name" value="DNAJ HEAT SHOCK N-TERMINAL DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14308">
        <property type="entry name" value="DnaJ-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="245"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="496"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="621" mass="69328" checksum="92CCFEE18BB29320" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVT8</accession>
    <name>Q5CVT8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Uridine kinase</fullName>
            <ecNumber evidence="12">2.7.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd8_2810</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>cytidine + ATP = CMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24674"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17562"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>uridine + ATP = UMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16825"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16704"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.48"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 12">Pyrimidine metabolism; CTP biosynthesis via salvage pathway; CTP from cytidine: step 1/3.</text>
    </comment>
    <comment type="pathway">
        <text evidence="4">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 12">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uridine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the uridine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.48" evidence="12"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627181.1">
        <property type="nucleotide sequence ID" value="XM_627181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVT8"/>
    <dbReference type="STRING" id="353152.Q5CVT8"/>
    <dbReference type="GeneID" id="3374330"/>
    <dbReference type="KEGG" id="cpv:cgd8_2810"/>
    <dbReference type="InParanoid" id="Q5CVT8"/>
    <dbReference type="OMA" id="EPQLHCE"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="UniPathway" id="UPA00574">
        <property type="reaction ID" value="UER00637"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00579">
        <property type="reaction ID" value="UER00640"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043771">
        <property type="term" value="F:cytidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004849">
        <property type="term" value="F:uridine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044211">
        <property type="term" value="P:CTP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044206">
        <property type="term" value="P:UMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02023">
        <property type="entry name" value="UMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000339">
        <property type="entry name" value="Uridine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006083">
        <property type="entry name" value="PRK/URK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000764">
        <property type="entry name" value="Uridine_kinase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004018">
        <property type="entry name" value="PRK05480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00235">
        <property type="entry name" value="udk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10285">
        <property type="entry name" value="URIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00485">
        <property type="entry name" value="PRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00988">
        <property type="entry name" value="URIDINKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 12 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribulokinase/uridine kinase" evidence="13">
        <location>
            <begin position="35"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="14">
        <location>
            <begin position="248"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK89700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="461" mass="52481" checksum="DF9482AE483E5943" modified="2005-04-12" version="1" fragment="single">FEYIMSNISLEKLISKDIYYGDQALTPSSNSNVFVIAVAGGSASGKTSVCTRIFSELGDKRVTVIETDSFYKTPVLEEGQTMADYNFDHPNSVDFELLYNVLLSLKNGEGVHIPNYCFKQHKRLETGRKVSPASIIIVEGIFILFHPKIRHLINMSIFVDTDDDIRLVRRIRRDTIERGRQIDDILNQYEKTVKPSYDEFIYPTRRYADIVIPHYPNEVAVDLVVQHLRYKLKMDDLRKIYSNLHIIPSNCQIRHMHSIIRNKDTSVVDFVFWSDRLIRLVVENALSHLSFTGQTIETPIGELYDGVQFNYKDKLCAVSIVRGGESMEIGLSAVCKDIPIGKILLEFQNPKTELDAQFDKPKIIYCKLPDDIASRNVFILDPILGNGFGVFSAIKYLLSKGVLQRKIIVLSLIVAHNAIHRICKEFPEVTLITTEIDRDVNSDGFVIPGLGCFADRYFGTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW09</accession>
    <name>Q5CW09_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane associated protein with a signal peptide and a transmembrane domain near the carboxy-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627110.1">
        <property type="nucleotide sequence ID" value="XM_627110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW09"/>
    <dbReference type="GeneID" id="3374497"/>
    <dbReference type="KEGG" id="cpv:cgd8_2060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2060"/>
    <dbReference type="InParanoid" id="Q5CW09"/>
    <dbReference type="OMA" id="NIETCIA"/>
    <dbReference type="OrthoDB" id="341379at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="660"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="713" mass="84719" checksum="00EF256B8FEE2986" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW23</accession>
    <name>Q5CW23_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">mannose-6-phosphate isomerase</fullName>
            <ecNumber evidence="5">5.3.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_1920</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-mannose 6-phosphate = D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:12356"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="5.3.1.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 1/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the mannose-6-phosphate isomerase type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.8" evidence="5"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627096.1">
        <property type="nucleotide sequence ID" value="XM_627096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW23"/>
    <dbReference type="STRING" id="353152.Q5CW23"/>
    <dbReference type="GeneID" id="3374467"/>
    <dbReference type="KEGG" id="cpv:cgd8_1920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1920"/>
    <dbReference type="InParanoid" id="Q5CW23"/>
    <dbReference type="OMA" id="EFAACIS"/>
    <dbReference type="OrthoDB" id="6605218at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00423"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004476">
        <property type="term" value="F:mannose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07011">
        <property type="entry name" value="cupin_PMI_type_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.441.10">
        <property type="entry name" value="Phosphomannose Isomerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001250">
        <property type="entry name" value="Man6P_Isoase-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016305">
        <property type="entry name" value="Mannose-6-P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018050">
        <property type="entry name" value="Pmannose_isomerase-type1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046457">
        <property type="entry name" value="PMI_typeI_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046458">
        <property type="entry name" value="PMI_typeI_hel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00218">
        <property type="entry name" value="manA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10309:SF0">
        <property type="entry name" value="MANNOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20511">
        <property type="entry name" value="PMI_typeI_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20512">
        <property type="entry name" value="PMI_typeI_hel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00965">
        <property type="entry name" value="PMI_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Phosphomannose isomerase type I catalytic" evidence="9">
        <location>
            <begin position="108"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphomannose isomerase type I helical insertion" evidence="10">
        <location>
            <begin position="275"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF20511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF20512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="576" mass="66077" checksum="F5CEE607881545FF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWB2</accession>
    <name>Q5CWB2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627007.1">
        <property type="nucleotide sequence ID" value="XM_627007.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3374432"/>
    <dbReference type="KEGG" id="cpv:cgd8_990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_990"/>
    <dbReference type="InParanoid" id="Q5CWB2"/>
    <dbReference type="OMA" id="LWASESH"/>
    <dbReference type="OrthoDB" id="343112at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1303" mass="152220" checksum="3AE77AD73D91DE08" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWB3</accession>
    <name>Q5CWB3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627006.1">
        <property type="nucleotide sequence ID" value="XM_627006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWB3"/>
    <dbReference type="STRING" id="353152.Q5CWB3"/>
    <dbReference type="GeneID" id="3374634"/>
    <dbReference type="KEGG" id="cpv:cgd8_980"/>
    <dbReference type="InParanoid" id="Q5CWB3"/>
    <dbReference type="OMA" id="KHILCNI"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="76" mass="8612" checksum="1A6784E0AB8A5841" modified="2005-04-12" version="1" fragment="single">IKKFLLLAMLGLGSKEVDFQTYLDLVSHKVMLKADKEELRTAFNVLDRYGNGKVLVSDLKHILCNIGEKLTVSYIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWD4</accession>
    <name>Q5CWD4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="22">cGMP-dependent protein kinase</fullName>
            <ecNumber evidence="6">2.7.11.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="28" type="ORF">cgd8_750</name>
    </gene>
    <organism evidence="28 29">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="28 29" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="29">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="24">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="23">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.12"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cell membrane</location>
            <topology evidence="2">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="28">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.12" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626985.1">
        <property type="nucleotide sequence ID" value="XM_626985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWD4"/>
    <dbReference type="SMR" id="Q5CWD4"/>
    <dbReference type="FunCoup" id="Q5CWD4">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWD4"/>
    <dbReference type="GeneID" id="3374520"/>
    <dbReference type="KEGG" id="cpv:cgd8_750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_750"/>
    <dbReference type="InParanoid" id="Q5CWD4"/>
    <dbReference type="OMA" id="ESCLADC"/>
    <dbReference type="OrthoDB" id="100546at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030553">
        <property type="term" value="F:cGMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004692">
        <property type="term" value="F:cGMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd05572">
        <property type="entry name" value="STKc_cGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000068">
        <property type="entry name" value="cGMP-dependent protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035014">
        <property type="entry name" value="STKc_cGK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16 25" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="10" id="KW-0140">cGMP</keyword>
    <keyword evidence="18" id="KW-0142">cGMP-binding</keyword>
    <keyword evidence="8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="15 28" id="KW-0418">Kinase</keyword>
    <keyword evidence="21" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="17" id="KW-0460">Magnesium</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0519">Myristate</keyword>
    <keyword evidence="14 25" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-0564">Palmitate</keyword>
    <keyword evidence="29" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="27">
        <location>
            <begin position="109"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="27">
        <location>
            <begin position="227"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="27">
        <location>
            <begin position="499"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="26">
        <location>
            <begin position="622"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="binding site" evidence="25">
        <location>
            <position position="651"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012428"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00024113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00047298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00047462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="EMBL" id="EAK89306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="965" mass="109031" checksum="D995BFFD9C70C50C" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWF2</accession>
    <name>Q5CWF2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_5330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627852.1">
        <property type="nucleotide sequence ID" value="XM_627852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWF2"/>
    <dbReference type="GeneID" id="3375847"/>
    <dbReference type="KEGG" id="cpv:cgd6_5330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5330"/>
    <dbReference type="InParanoid" id="Q5CWF2"/>
    <dbReference type="OMA" id="DACHITY"/>
    <dbReference type="OrthoDB" id="336593at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="906" mass="104524" checksum="5544BA5E09144B3E" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWF5</accession>
    <name>Q5CWF5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_5300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627849.1">
        <property type="nucleotide sequence ID" value="XM_627849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWF5"/>
    <dbReference type="STRING" id="353152.Q5CWF5"/>
    <dbReference type="GeneID" id="3375845"/>
    <dbReference type="KEGG" id="cpv:cgd6_5300"/>
    <dbReference type="InParanoid" id="Q5CWF5"/>
    <dbReference type="OrthoDB" id="341624at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="427" mass="47704" checksum="10C48307634EF881" modified="2005-04-12" version="1">MAPKYILSFLCLQYPTGQVQTNKKTDSDGSLEIFITSKENSMVVDVPDSEYVQEGAVLLGIWNDNTIFLRFEATKEIHKVKTAYPKPQMIGQRFQRGSSLVILEISAPLTPQNTILENHTSYFSHVEPQRDNSVSTPEQSEKDDSNREASASGFEVDQSIQQLDTSPAKLDESVENEHFESQDPLPTYTQTDKDELQEVSNSHIISIHEKQPIETALDNSAITYAIMMRNQIKKSKLHNLNKNFDLVNQKAKWIVRAPCSGTITSKKLTRNVKKVLQGTLYATIQCNSKKGRGKGAFENKGKEIALIMPFSIKINKIKADLQETEQPGLYSAQVSKNQSIITGKLIKESKDIPPHLIYGKFQLVTAPCSGILRNTVEIGKSVRKKDTIFSVDCVEAGKDSIMYGVTTKPGLVTKMFKENQANVKVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWK0</accession>
    <name>Q5CWK0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Pre-mRNA-splicing factor CWC2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd6_4770</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRM CWC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627804.1">
        <property type="nucleotide sequence ID" value="XM_627804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWK0"/>
    <dbReference type="STRING" id="353152.Q5CWK0"/>
    <dbReference type="GeneID" id="3375806"/>
    <dbReference type="KEGG" id="cpv:cgd6_4770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4770"/>
    <dbReference type="InParanoid" id="Q5CWK0"/>
    <dbReference type="OMA" id="LENVEQC"/>
    <dbReference type="OrthoDB" id="10251848at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032297">
        <property type="entry name" value="Torus"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16131">
        <property type="entry name" value="Torus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 12" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7 13" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="146"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="13">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK90061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="342" mass="39478" checksum="30995C1217EF4E6D" modified="2007-04-03" version="1">MDKVPVEFKRKPTVEELKRPARAQSDGSLQSNLAYKEGGELYNIWYGKYQFDYDKRGKVASKTKCIPDKDSGWTKADQDPNTKSYFCLYFAKGACVNGSKCKYFHRIPTEEDDRLVSPMYDVFGRERHAQHKDDMTGTGSFNKECRTIFVGDLYINRSKSNYLEGVNKVIKKEFSVWGPVDYIRVIPSKNIAFVRYFLRSSAEFAKAAMENQIIFKGQTDPITVRWAYDDPNPTSMENSKKRNAEEVEEFVSNLDIEKKSRSDLQVNNETEGFFSHIDSTSHNVPSEEVLKIQKDYYRVEKILESIKSCQTKNLCKSTNIEKGNSEDDESEKQENSIYDVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWN0</accession>
    <name>Q5CWN0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_4430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627774.1">
        <property type="nucleotide sequence ID" value="XM_627774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWN0"/>
    <dbReference type="GeneID" id="3375784"/>
    <dbReference type="KEGG" id="cpv:cgd6_4430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4430"/>
    <dbReference type="InParanoid" id="Q5CWN0"/>
    <dbReference type="OrthoDB" id="342041at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="334" mass="38827" checksum="9BEA8D0494751B48" modified="2007-04-03" version="1">MEISDKIAFDGYKHNNLVLQKLKNNKERKVTESSQKCSERIENKLGNIFREISLRNESNAYKITMSSEIQRITNMNKLDAYYKFLVLSYSKMFLAFISLKNDCELEDVHFHTLELRKLNYIFKNCTHFRISCKLFEGKSDSNLVKKTNNILKEISISKKEKPSQKDKLDLLNKIDSLNSSANNLKTKIKHYFSNNIQEEINVCKYTQVNEEPILLISSESNTDLCTSDSSCLEVSNDENSSNSEEETNLVNKNKDRIELETKDKYNFRHRRSIETISFRGKKLENYPLVEFSPAPKYHSRSKTQNTSFLEHGQSVNKLCVSFNGILLNKQPIDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWR0</accession>
    <name>Q5CWR0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627744.1">
        <property type="nucleotide sequence ID" value="XM_627744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWR0"/>
    <dbReference type="GeneID" id="3375758"/>
    <dbReference type="KEGG" id="cpv:cgd6_4100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4100"/>
    <dbReference type="InParanoid" id="Q5CWR0"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="101" mass="11823" checksum="5C8087C52EA75AC4" modified="2007-04-03" version="1">MGLIQPVHYLELSILANYFIKKKILSNKAKLLTGPLIYISVHPLTFLPQKLSHTTIKQKKSRRNFTWRFSFITILIHQIIWHFTKSIHLSSAIPSLEWLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWT9</accession>
    <name>Q5CWT9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627715.1">
        <property type="nucleotide sequence ID" value="XM_627715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWT9"/>
    <dbReference type="GeneID" id="3375732"/>
    <dbReference type="KEGG" id="cpv:cgd6_3760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3760"/>
    <dbReference type="InParanoid" id="Q5CWT9"/>
    <dbReference type="OMA" id="SESKHAW"/>
    <dbReference type="OrthoDB" id="342408at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="805" mass="92130" checksum="1BA8AC78110FCC33" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWU9</accession>
    <name>Q5CWU9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein disulfide isomerase secreted protein with thioredoxin, signal peptide plus ER retention motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_3640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627705.1">
        <property type="nucleotide sequence ID" value="XM_627705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWU9"/>
    <dbReference type="GeneID" id="3375726"/>
    <dbReference type="KEGG" id="cpv:cgd6_3640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3640"/>
    <dbReference type="InParanoid" id="Q5CWU9"/>
    <dbReference type="OMA" id="NEGFEIM"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255038" evidence="2">
        <location>
            <begin position="25"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="439"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="575" mass="65820" checksum="F64EFDC5AF29A9C8" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWW4</accession>
    <name>Q5CWW4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627690.1">
        <property type="nucleotide sequence ID" value="XM_627690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWW4"/>
    <dbReference type="GeneID" id="3375713"/>
    <dbReference type="KEGG" id="cpv:cgd6_3470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3470"/>
    <dbReference type="InParanoid" id="Q5CWW4"/>
    <dbReference type="OMA" id="FMEINTD"/>
    <dbReference type="OrthoDB" id="339159at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="109"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="243" mass="27460" checksum="2FD8F7588BF972F3" modified="2007-04-03" version="1">MGGKQSVPQTYEAFSGRMGKFPSLSEDILTKQELEEGVVILDSLNSMRKMNSSTFMDIESDNTRFMMARAEADRIAEAEALRLATEQSIRVNDEGSIVYQSSYISLPSRKDSTISKQPTRSGTVLSKQSTKNSLVALDENLEEEILDNERNLEYIPSKSNIDSEENRREIFEMITNRCGVVFSECKSYPVEEARKLRNDLRNCDSEYAIDKTAETCGCLGPKHDRLNCPICRGMHLEDAPLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX07</accession>
    <name>Q5CX07_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_2990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627647.1">
        <property type="nucleotide sequence ID" value="XM_627647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX07"/>
    <dbReference type="GeneID" id="3375675"/>
    <dbReference type="KEGG" id="cpv:cgd6_2990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2990"/>
    <dbReference type="InParanoid" id="Q5CX07"/>
    <dbReference type="OMA" id="IRELIIM"/>
    <dbReference type="OrthoDB" id="340230at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="260" mass="29520" checksum="4061A8E350B49714" modified="2007-04-03" version="1">MKDIKKVAETIKLLVAYREKSVRIFGDGLDLRAPIQPLFPTKAENISGTENSISRSSLESRTITTDAADLLNELAAMHYEWALDNYAKVRTRDHQEQQKKCSAIQKEEIAAPSPYLSYLSSQYDGIDSPIVGEILENKHGYIVMECILLLLNQNNSIEYGTEHFKKYASLMLLLSDILRCMKRQKSLHCDTMDFHVLVDILFREMVIMRDSGFALFEYVSCLNIVIKCIASTKEKYRWGEATSLLSVTESLIEGFGVSSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX10</accession>
    <name>Q5CX10_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Bax inhibitor-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_2960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627644.1">
        <property type="nucleotide sequence ID" value="XM_627644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX10"/>
    <dbReference type="FunCoup" id="Q5CX10">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX10"/>
    <dbReference type="GeneID" id="3375673"/>
    <dbReference type="KEGG" id="cpv:cgd6_2960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2960"/>
    <dbReference type="InParanoid" id="Q5CX10"/>
    <dbReference type="OMA" id="SRDFIMH"/>
    <dbReference type="OrthoDB" id="1277691at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF32">
        <property type="entry name" value="BAX INHIBITOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="60"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="174"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="246" mass="27757" checksum="D02723DD5EE24EC7" modified="2007-04-03" version="1">MESFFATNSRKSQFSGNFFNSSDLTSIQQTHLLKMYSSIIAGSFMTVFGVTAFINGMLRINSFVGLLAGIGVTFYLTASSSNKSSISIKRLAAYLLLCFVIGNGLGPLILFSNFVNPVIIPTALATTCIIFISLSFGVLFTKKRLSLYTTSFIFTTIAYLGLVSFFNIFTRSKFVDSLLSYAFVMVYSFYIYYDTQKTLEAIAYGERDFLLHSIQLYLDAVNLFTKIVVILIRKQQEEEEKRRKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX16</accession>
    <name>Q5CX16_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Exostosin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627638.1">
        <property type="nucleotide sequence ID" value="XM_627638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX16"/>
    <dbReference type="GeneID" id="3376163"/>
    <dbReference type="KEGG" id="cpv:cgd6_2900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2900"/>
    <dbReference type="InParanoid" id="Q5CX16"/>
    <dbReference type="OrthoDB" id="1924787at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040911">
        <property type="entry name" value="Exostosin_GT47"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03016">
        <property type="entry name" value="Exostosin_GT47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exostosin GT47" evidence="1">
        <location>
            <begin position="86"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="220" mass="25857" checksum="EEE8A7A4FC6CEB5C" modified="2005-04-12" version="1">MSMSNLIVFNAGGATTGFKQVPIPLIKGELQYEGLKAKKDIWVSSTIVKKHFPVRKKLFETFSYYNVTDEMLDKITPFKVLENVTNQFIHYQGDQFKQVIQRSTFHLCPRGFGRTSFRLYESVQLGTIPIYIWDDVNWIPYGNLMERLGIVIHISQIEDLFDILNSLSEDELKFKFEQIKKFKHWFTYLGITNYILKVIKRLPPDIILKQNIESKYLALY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXC9</accession>
    <name>Q5CXC9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Exonuclease 1</fullName>
            <ecNumber evidence="12">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd6_1580</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">5'-&gt;3' double-stranded DNA exonuclease which may also possess a cryptic 3'-&gt;5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="12"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627525.1">
        <property type="nucleotide sequence ID" value="XM_627525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXC9"/>
    <dbReference type="STRING" id="353152.Q5CXC9"/>
    <dbReference type="GeneID" id="3376109"/>
    <dbReference type="KEGG" id="cpv:cgd6_1580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1580"/>
    <dbReference type="InParanoid" id="Q5CXC9"/>
    <dbReference type="OMA" id="FPSSECH"/>
    <dbReference type="OrthoDB" id="26491at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035312">
        <property type="term" value="F:5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09857">
        <property type="entry name" value="PIN_EXO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000111">
        <property type="entry name" value="Exonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044752">
        <property type="entry name" value="PIN-like_EXO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF8">
        <property type="entry name" value="EXONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0227">DNA damage</keyword>
    <keyword evidence="12" id="KW-0228">DNA excision</keyword>
    <keyword evidence="10 12" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0267">Excision nuclease</keyword>
    <keyword evidence="7 12 16" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 12" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="15">
        <location>
            <begin position="1"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="14">
        <location>
            <begin position="142"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="387"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU910737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK89830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="482" mass="54748" checksum="0904F9445F09BBF7" modified="2007-04-03" version="1">MGIQGLLPNVDNISIKSKIDFFKGKRVAIDTYGWLHRSAANCAESIVLGKPTRVHINYCIEKIRTLQGKGLIPVCVFDGATLPMKRVTEEERSKRRSDAKREIIRLKSEKKSYSSYNMRSLCQKALDITPNIAHQVLEVLRDEYKIECIVAPYEADAQLSYLSRIKYIDAVITEDSDMLVFGSICTIYKYDDKTGNCRVIYWKDLYKSGVISQLMFSYETFVLGCILTGCDYVKSPQGVGIKTAMKLVQECNADLERIILQLKDLGKDIPQSYAIDVQNAMITFFHQTVYDPIEGNMVPLSNSDRPKSEIETNVTLDNVPIFIEFNNQMKQGNLIECNEMKNFIGPIIQGKVAKDICLGFIHPETHLAFDDPINSHSEFQLNLGHDCNNRDNQIKPSRDSRASLEKENLDDNTGKSECDIEELIKQSIRSPVNRKKSNISLFSHKESHVGLKKKRRAIWLGSEVENNAIKEIKLLDNLAYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXE2</accession>
    <name>Q5CXE2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627512.1">
        <property type="nucleotide sequence ID" value="XM_627512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXE2"/>
    <dbReference type="GeneID" id="3375871"/>
    <dbReference type="KEGG" id="cpv:cgd6_1440"/>
    <dbReference type="InParanoid" id="Q5CXE2"/>
    <dbReference type="OMA" id="NTHDTVN"/>
    <dbReference type="OrthoDB" id="343258at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="347"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="642"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="711" mass="82151" checksum="087467AD652B827C" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXF7</accession>
    <name>Q5CXF7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_1260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627497.1">
        <property type="nucleotide sequence ID" value="XM_627497.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3376039"/>
    <dbReference type="KEGG" id="cpv:cgd6_1260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1260"/>
    <dbReference type="InParanoid" id="Q5CXF7"/>
    <dbReference type="OMA" id="SHITIFL"/>
    <dbReference type="OrthoDB" id="341993at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1486" mass="174661" checksum="B026D136EA12C3EA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXG3</accession>
    <name>Q5CXG3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">diphthine methyl ester synthase</fullName>
            <ecNumber evidence="4">2.1.1.314</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_1200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 4 S-adenosyl-L-methionine = diphthine methyl ester-[translation elongation factor 2] + 4 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42652"/>
            <dbReference type="Rhea" id="RHEA-COMP:9749"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73995"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="EC" id="2.1.1.314"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the diphthine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.314" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627491.1">
        <property type="nucleotide sequence ID" value="XM_627491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXG3"/>
    <dbReference type="FunCoup" id="Q5CXG3">
        <property type="interactions" value="432"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXG3"/>
    <dbReference type="GeneID" id="3375866"/>
    <dbReference type="KEGG" id="cpv:cgd6_1200"/>
    <dbReference type="InParanoid" id="Q5CXG3"/>
    <dbReference type="OMA" id="HNASIMS"/>
    <dbReference type="OrthoDB" id="2516at2759"/>
    <dbReference type="UniPathway" id="UPA00559"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141133">
        <property type="term" value="F:diphthine methyl ester synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11647">
        <property type="entry name" value="DHP5_DphB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.950.10:FF:000004">
        <property type="entry name" value="Diphthine synthase putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1010.10">
        <property type="entry name" value="Cobalt-precorrin-4 Transmethylase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.950.10">
        <property type="entry name" value="Methyltransferase, Cobalt-precorrin-4 Transmethylase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01084">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000878">
        <property type="entry name" value="4pyrrol_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035996">
        <property type="entry name" value="4pyrrol_Methylase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014777">
        <property type="entry name" value="4pyrrole_Mease_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014776">
        <property type="entry name" value="4pyrrole_Mease_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004551">
        <property type="entry name" value="Dphthn_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00522">
        <property type="entry name" value="dph5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882:SF0">
        <property type="entry name" value="DIPHTHINE METHYL ESTER SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10882">
        <property type="entry name" value="DIPHTHINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00590">
        <property type="entry name" value="TP_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036432">
        <property type="entry name" value="Diphthine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53790">
        <property type="entry name" value="Tetrapyrrole methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Tetrapyrrole methylase" evidence="10">
        <location>
            <begin position="7"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="14"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="117"/>
            <end position="118"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="251"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR036432-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00590"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK90121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="274" mass="31000" checksum="F5FDBA2E18CB311D" modified="2005-04-12" version="1" fragment="single">KFTTMVLYLIGTGLNDERDMTLGGIELMKVADKIYLESYTSILSQRADLMKYTDGKPLIEADRKMVEENCDEIIEEAKDKSIVLLVVGDPFCATTHSDLVLRAHEKDVKVEVRHNASIISAIGCTGLQVYRFGETVSIPFFDGSWQPSSFYDKIKANIERGLHTLCLLDIKVKEQTIENMMRNRPIFEPPRFMTVNQAISQLFILEDKLKQNVISPNSLAIGVARIGSSDQKIVSGTLSELSDTDFGNPLHSLVICHPDLHLIEQRFFEIYRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXI8</accession>
    <name>Q5CXI8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">rRNA adenine N(6)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_930</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6 7">Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627466.1">
        <property type="nucleotide sequence ID" value="XM_627466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXI8"/>
    <dbReference type="FunCoup" id="Q5CXI8">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXI8"/>
    <dbReference type="GeneID" id="3376090"/>
    <dbReference type="KEGG" id="cpv:cgd6_930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_930"/>
    <dbReference type="InParanoid" id="Q5CXI8"/>
    <dbReference type="OMA" id="GMFQKEV"/>
    <dbReference type="OrthoDB" id="74991at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000179">
        <property type="term" value="F:rRNA (adenine-N6,N6-)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000081">
        <property type="entry name" value="rRNA adenine N(6)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.480">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001737">
        <property type="entry name" value="KsgA/Erm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020598">
        <property type="entry name" value="rRNA_Ade_methylase_Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011530">
        <property type="entry name" value="rRNA_adenine_dimethylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00755">
        <property type="entry name" value="ksgA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11727:SF7">
        <property type="entry name" value="DIMETHYLADENOSINE TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00398">
        <property type="entry name" value="RrnaAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00650">
        <property type="entry name" value="rADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51689">
        <property type="entry name" value="SAM_RNA_A_N6_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4 6 7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA adenine methylase transferase N-terminal" evidence="9">
        <location>
            <begin position="72"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="366"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="67"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="155"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="385" mass="43463" checksum="477CBEB7D390CC51" modified="2007-04-03" version="1">MVVIRKEYLTKNRPNKLNINELSGKVIKNGSGIQKQTSNSQNSSHNKGGGSSFVNVILDKKKGQHLLKNTGILDKIILAADIKPTDTVLEIGPGTGNLTMRLLPLARKVVAFDIDPRMVAEVKKRSVNSGFNNLEVREGDALRSSFGDFDVCTANLPYQISSPFVFKLLSLQNKYRCAVLMFQEEFALRLLAEPGEKHYCRLSVNTKLFSKVTRVCKVAPGSFNPPPKVNSMVVKFEPKKIPVSVNFREWDGLMRICFSRKKKTIRANFNNSSVLNILENNYKVWSSINQKDPCGNMPFKTFIFKILEDSGLSSKRGFNVDINEYFRLLFEFNKNGVHFVNIIQGNTSNDNSDHFEFLFSNAESDLDENMEGNNNSSDDEFNMTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXI9</accession>
    <name>Q5CXI9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Sec20 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the SEC20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627465.1">
        <property type="nucleotide sequence ID" value="XM_627465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXI9"/>
    <dbReference type="STRING" id="353152.Q5CXI9"/>
    <dbReference type="GeneID" id="3376088"/>
    <dbReference type="KEGG" id="cpv:cgd6_910"/>
    <dbReference type="InParanoid" id="Q5CXI9"/>
    <dbReference type="OMA" id="MNHKEDE"/>
    <dbReference type="OrthoDB" id="365988at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005606">
        <property type="entry name" value="Sec20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056173">
        <property type="entry name" value="Sec20_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825">
        <property type="entry name" value="BNIP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12825:SF0">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SEC20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03908">
        <property type="entry name" value="Sec20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="75"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="Sec20 C-terminal" evidence="11">
        <location>
            <begin position="7"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="134" mass="16073" checksum="5B50598E609380C5" modified="2007-04-03" version="1">MSEDQESTELQNQLFETKNKMKQEVDRFHKSEQILTEDKNSLLNANDTYKQYGDKLASNFQKFKTIKKKSEQETLFLWYSFYFLIIVSLYIIFRRLGIIYILIQKPIILIFKAIKYIIKFFIINNYDGSAKSEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXL4</accession>
    <name>Q5CXL4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor 100 kDa subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627440.1">
        <property type="nucleotide sequence ID" value="XM_627440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXL4"/>
    <dbReference type="STRING" id="353152.Q5CXL4"/>
    <dbReference type="GeneID" id="3376050"/>
    <dbReference type="KEGG" id="cpv:cgd6_580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_580"/>
    <dbReference type="InParanoid" id="Q5CXL4"/>
    <dbReference type="OMA" id="YVENDIM"/>
    <dbReference type="OrthoDB" id="64353at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027075">
        <property type="entry name" value="CPSF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45922:SF1">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Beta-Casp" evidence="3">
        <location>
            <begin position="297"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="645"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="645"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="676"/>
            <end position="687"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1196" mass="135127" checksum="89ADCAF218A4B475" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXL6</accession>
    <name>Q5CXL6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alanine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd6_560</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>tRNA(Ala) + L-alanine + ATP = L-alanyl-tRNA(Ala) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:12540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:9923"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57972"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78497"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.7" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627438.1">
        <property type="nucleotide sequence ID" value="XM_627438.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXL6"/>
    <dbReference type="FunCoup" id="Q5CXL6">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXL6"/>
    <dbReference type="GeneID" id="3375859"/>
    <dbReference type="KEGG" id="cpv:cgd6_560"/>
    <dbReference type="InParanoid" id="Q5CXL6"/>
    <dbReference type="OMA" id="QYNKDEK"/>
    <dbReference type="OrthoDB" id="2423964at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004813">
        <property type="term" value="F:alanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006419">
        <property type="term" value="P:alanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00673">
        <property type="entry name" value="AlaRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000011">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000004">
        <property type="entry name" value="Alanine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00036_B">
        <property type="entry name" value="Ala_tRNA_synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002318">
        <property type="entry name" value="Ala-tRNA-lgiase_IIc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018162">
        <property type="entry name" value="Ala-tRNA-ligase_IIc_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018165">
        <property type="entry name" value="Ala-tRNA-synth_IIc_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018164">
        <property type="entry name" value="Ala-tRNA-synth_IIc_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050058">
        <property type="entry name" value="Ala-tRNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023033">
        <property type="entry name" value="Ala_tRNA_ligase_euk/bac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00344">
        <property type="entry name" value="alaS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777:SF9">
        <property type="entry name" value="ALANINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11777">
        <property type="entry name" value="ALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01411">
        <property type="entry name" value="tRNA-synt_2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00980">
        <property type="entry name" value="TRNASYNTHALA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101353">
        <property type="entry name" value="Putative anticodon-binding domain of alanyl-tRNA synthetase (AlaRS)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50860">
        <property type="entry name" value="AA_TRNA_LIGASE_II_ALA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0820">tRNA-binding</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Alanyl-transfer RNA synthetases family profile" evidence="15">
        <location>
            <begin position="21"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="795"/>
            <end position="822"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017959"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK90114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1003" mass="114037" checksum="826F32A94EB5DCE8" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXQ9</accession>
    <name>Q5CXQ9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">FACT complex subunit SSRP1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd7_5280</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the SSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628671.1">
        <property type="nucleotide sequence ID" value="XM_628669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXQ9"/>
    <dbReference type="FunCoup" id="Q5CXQ9">
        <property type="interactions" value="553"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXQ9"/>
    <dbReference type="GeneID" id="3372099"/>
    <dbReference type="KEGG" id="cpv:cgd7_5280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5280"/>
    <dbReference type="InParanoid" id="Q5CXQ9"/>
    <dbReference type="OMA" id="QVVTKIF"/>
    <dbReference type="OrthoDB" id="498543at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13230">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13231">
        <property type="entry name" value="PH2_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.150:FF:000001">
        <property type="entry name" value="Fact complex subunit ssrp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.220">
        <property type="entry name" value="Structure-specific recognition protein (SSRP1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050454">
        <property type="entry name" value="RTT106/SSRP1_HistChap/FACT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048993">
        <property type="entry name" value="SSRP1-like_PH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000969">
        <property type="entry name" value="SSRP1/POB3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035417">
        <property type="entry name" value="SSRP1/POB3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024954">
        <property type="entry name" value="SSRP1_DD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038167">
        <property type="entry name" value="SSRP1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45849:SF1">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SSRP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21103">
        <property type="entry name" value="PH1_SSRP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17292">
        <property type="entry name" value="POB3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03531">
        <property type="entry name" value="SSrecog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00887">
        <property type="entry name" value="SSRCOGNITION"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7 9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 9" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 9" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="11">
        <location>
            <begin position="352"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="444"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="457"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="478"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="503"/>
            <end position="523"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU364013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="523" mass="59376" checksum="4F5770B2F78BFBC3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXR6</accession>
    <name>Q5CXR6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bromodomain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_5210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628664.1">
        <property type="nucleotide sequence ID" value="XM_628662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXR6"/>
    <dbReference type="STRING" id="353152.Q5CXR6"/>
    <dbReference type="GeneID" id="3372095"/>
    <dbReference type="KEGG" id="cpv:cgd7_5210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5210"/>
    <dbReference type="InParanoid" id="Q5CXR6"/>
    <dbReference type="OMA" id="RWILLQI"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052442">
        <property type="entry name" value="Env_Response_Regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46136:SF1">
        <property type="entry name" value="TRANSCRIPTION FACTOR GTE11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46136">
        <property type="entry name" value="TRANSCRIPTION FACTOR GTE8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="4">
        <location>
            <begin position="176"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="47"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="384"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="487"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="61"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="86"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="120"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="407"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="423"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="513" mass="57874" checksum="6458D6150122F931" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXV9</accession>
    <name>Q5CXV9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UV excision repair protein RAD23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_4730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the RAD23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628621.1">
        <property type="nucleotide sequence ID" value="XM_628619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXV9"/>
    <dbReference type="FunCoup" id="Q5CXV9">
        <property type="interactions" value="379"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXV9"/>
    <dbReference type="GeneID" id="3371951"/>
    <dbReference type="KEGG" id="cpv:cgd7_4730"/>
    <dbReference type="InParanoid" id="Q5CXV9"/>
    <dbReference type="OMA" id="PHMLEPI"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14280">
        <property type="entry name" value="UBA1_Rad23_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ubl_Rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000002">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.10:FF:000003">
        <property type="entry name" value="UV excision repair protein RAD23 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.540">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004806">
        <property type="entry name" value="Rad23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015360">
        <property type="entry name" value="XPC-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036353">
        <property type="entry name" value="XPC-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00601">
        <property type="entry name" value="rad23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10621:SF0">
        <property type="entry name" value="UV EXCISION REPAIR PROTEIN RAD23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09280">
        <property type="entry name" value="XPC-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01839">
        <property type="entry name" value="RAD23PROTEIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101238">
        <property type="entry name" value="XPC-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3 5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="8">
        <location>
            <begin position="22"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="153"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="312"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="100"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="198"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="103"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="204"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="362" mass="40043" checksum="92A149C6944EE883" modified="2005-04-12" version="1" fragment="single">VKQKKTIKGRKKSIQKNLRNAMKIKIRTVQNTEMEVEVEADYSIEKVKQAIQELNPVMEASRLKLIFAGRILNDSQTVQDVGIKEGERLVVLLSKGASQKAAESQQNKQNNTSNESNTNTDPAASATTSNIQAQSGNSDPSIDSRASALLTGTELEKTITNIVNMGFEREQVTRAMRAAFNNPDRAVEYLTSGLPIPENPVAPNHTNITPVNSNASLNAGLTSSEDLSSEQLPGNLESLRTNPLFQQLRSVVQQDPRILPELLVRIGQSNPEILQLITENQEEFIRMMERTDSDEVGETSQFPMQTTIQLTPQEAESVERLQALGFPRNAVIEAYLICEKNEELAANYLLENSADFFTDGAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY31</accession>
    <name>Q5CY31_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628549.1">
        <property type="nucleotide sequence ID" value="XM_628547.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372134"/>
    <dbReference type="KEGG" id="cpv:cgd7_3870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3870"/>
    <dbReference type="InParanoid" id="Q5CY31"/>
    <dbReference type="OMA" id="FFDIRIC"/>
    <dbReference type="OrthoDB" id="340207at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1059"/>
            <end position="1093"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1347"/>
            <end position="1377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1459"/>
            <end position="1493"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1589"/>
            <end position="1656"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1665" mass="195129" checksum="5D4A78D1080AA8EE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY32</accession>
    <name>Q5CY32_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628548.1">
        <property type="nucleotide sequence ID" value="XM_628546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY32"/>
    <dbReference type="GeneID" id="3372135"/>
    <dbReference type="KEGG" id="cpv:cgd7_3860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3860"/>
    <dbReference type="InParanoid" id="Q5CY32"/>
    <dbReference type="OMA" id="IGISCKE"/>
    <dbReference type="OrthoDB" id="338710at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253964" evidence="1">
        <location>
            <begin position="24"/>
            <end position="1259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1259" mass="145879" checksum="21A6F88D32B90548" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY81</accession>
    <name>Q5CY81_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA topoisomerase 1</fullName>
            <ecNumber evidence="3">5.6.2.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">DNA topoisomerase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd7_3350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the type IB topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628499.1">
        <property type="nucleotide sequence ID" value="XM_628497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY81"/>
    <dbReference type="FunCoup" id="Q5CY81">
        <property type="interactions" value="250"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY81"/>
    <dbReference type="GeneID" id="3371981"/>
    <dbReference type="KEGG" id="cpv:cgd7_3350"/>
    <dbReference type="InParanoid" id="Q5CY81"/>
    <dbReference type="OMA" id="HRWKEVK"/>
    <dbReference type="OrthoDB" id="47179at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03490">
        <property type="entry name" value="Topoisomer_IB_N_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.170.11.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.11.10">
        <property type="entry name" value="DNA Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.15.10">
        <property type="entry name" value="Topoisomerase I, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.41">
        <property type="entry name" value="Yeast DNA topoisomerase - domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011010">
        <property type="entry name" value="DNA_brk_join_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013034">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013030">
        <property type="entry name" value="DNA_topo_DNA_db_N_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001631">
        <property type="entry name" value="TopoI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025834">
        <property type="entry name" value="TopoI_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014711">
        <property type="entry name" value="TopoI_cat_a-hlx-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014727">
        <property type="entry name" value="TopoI_cat_a/b-sub_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013500">
        <property type="entry name" value="TopoI_cat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008336">
        <property type="entry name" value="TopoI_DNA-bd_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036202">
        <property type="entry name" value="TopoI_DNA-bd_euk_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013499">
        <property type="entry name" value="TopoI_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051062">
        <property type="entry name" value="Topoisomerase_IB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290:SF3">
        <property type="entry name" value="DNA TOPOISOMERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10290">
        <property type="entry name" value="DNA TOPOISOMERASE I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14370">
        <property type="entry name" value="Topo_C_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01028">
        <property type="entry name" value="Topoisom_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02919">
        <property type="entry name" value="Topoisom_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00416">
        <property type="entry name" value="EUTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00435">
        <property type="entry name" value="TOPEUc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56349">
        <property type="entry name" value="DNA breaking-rejoining enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56741">
        <property type="entry name" value="Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52038">
        <property type="entry name" value="TOPO_IB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 9 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="DNA topoisomerase I eukaryotic-type" evidence="10">
        <location>
            <begin position="199"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="active site" description="O-(3'-phospho-DNA)-tyrosine intermediate" evidence="9">
        <location>
            <position position="612"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00019632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033297"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00435"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK90633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="653" mass="76177" checksum="09D0F750F8154ACF" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY83</accession>
    <name>Q5CY83_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ced12 family of proteins that are conserved throughout eukaryotes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628497.1">
        <property type="nucleotide sequence ID" value="XM_628495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY83"/>
    <dbReference type="GeneID" id="3372049"/>
    <dbReference type="KEGG" id="cpv:cgd7_3330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3330"/>
    <dbReference type="InParanoid" id="Q5CY83"/>
    <dbReference type="OMA" id="TEEMCKS"/>
    <dbReference type="OrthoDB" id="67155at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF56">
        <property type="entry name" value="CED-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="97"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="383" mass="44650" checksum="AD9C4D856746F920" modified="2005-04-12" version="1">MPHPDTVKGKIPSVFHDITTKNSFIPDITINSYEIHVDGSFQDIIKEKLRREKSGKTIYNKIQISIINRFWKLSKERKLLHYIRNKCLISLNCADPNHEQLFQDYWALAYPDYPEINRISSNWRLLGFQNDDPRFDFKCAELLTLENLVYFAENYRNIFKVILKESQRFSSSEKIKYSHQHSIQRSIINSHKINGMMSPFETPHNFQPSSSNLSIITTPINMKDSKKEFGSNFEPLLPKVTELRSTISEISNSSQIDQMNFSYPLSTALINVSIMICLYLNFIPSIYKIPGVPNVSASRKAMKNFMRLTNEFSFNTISELFSVCAIRFHAEWLDIVKFLGHKVAISEFDKVLKNVQVVMAETIENLPKDIIEFRQICNLEKYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYD0</accession>
    <name>Q5CYD0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical large low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_2820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628450.1">
        <property type="nucleotide sequence ID" value="XM_628448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYD0"/>
    <dbReference type="GeneID" id="3372268"/>
    <dbReference type="KEGG" id="cpv:cgd7_2820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2820"/>
    <dbReference type="InParanoid" id="Q5CYD0"/>
    <dbReference type="OMA" id="EWGETEG"/>
    <dbReference type="OrthoDB" id="343842at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="883" mass="105660" checksum="6143056038A00C28" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYH0</accession>
    <name>Q5CYH0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">EB1 like microtubule binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd7_2370</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAPRE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628410.1">
        <property type="nucleotide sequence ID" value="XM_628408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYH0"/>
    <dbReference type="SMR" id="Q5CYH0"/>
    <dbReference type="STRING" id="353152.Q5CYH0"/>
    <dbReference type="GeneID" id="3372209"/>
    <dbReference type="KEGG" id="cpv:cgd7_2370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2370"/>
    <dbReference type="InParanoid" id="Q5CYH0"/>
    <dbReference type="OMA" id="HTHWIKH"/>
    <dbReference type="OrthoDB" id="2119228at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.418.10:FF:000028">
        <property type="entry name" value="RP/EB family microtubule-associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004953">
        <property type="entry name" value="EB1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036133">
        <property type="entry name" value="EB1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027328">
        <property type="entry name" value="MAPRE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10623">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN RP/EB FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00307">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03271">
        <property type="entry name" value="EB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140612">
        <property type="entry name" value="EB1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51230">
        <property type="entry name" value="EB1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="10">
        <location>
            <begin position="19"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="EB1 C-terminal" evidence="11">
        <location>
            <begin position="186"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="285" mass="32596" checksum="AC0113257CC07119" modified="2005-04-12" version="1">MTSTYDSIGGMGMMDKCYFTGKSDLLNWLNSYFNLNVSRIEDCASGAIYCQIADAVYYYQVPMKNVNWGVKHDFQYLHNYKLLQQVFGKVNQPKYIDINKLIKGKYQDNLEFLQWMKGLFDESGAIDRDYDAIGRRSLGKGPFPQYSGQVIPIASIQNTSADSSLNTAINNSNLAPNSKNSNTKNMLPSKNTEIEKLKKSLRKEIEEKEIVDKERMFYFNKLRAIEILYEELNEKKIPFMSLKDISEILYDSNDIDLESFSRKIIDSATINSNGLTSTTSGVEEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYN8</accession>
    <name>Q5CYN8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nop15p/nopp34 nucleolar protein with 1 RRM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_1620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628342.1">
        <property type="nucleotide sequence ID" value="XM_628340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYN8"/>
    <dbReference type="STRING" id="353152.Q5CYN8"/>
    <dbReference type="GeneID" id="3371786"/>
    <dbReference type="KEGG" id="cpv:cgd7_1620"/>
    <dbReference type="InParanoid" id="Q5CYN8"/>
    <dbReference type="OMA" id="PYIFIRS"/>
    <dbReference type="OrthoDB" id="21467at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12307">
        <property type="entry name" value="RRM_NIFK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46754">
        <property type="entry name" value="MKI67 FHA DOMAIN-INTERACTING NUCLEOLAR PHOSPHOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="16"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="156" mass="18176" checksum="411AEDC096C71D68" modified="2005-04-12" version="1" fragment="single">VLYIFIYMSKAKRERAIVYVGHIPFGLFEPQLKEYFSQFGKILRIKLSRSKKNGHSRGYAFIEFESMEVAQIAASTMNNYIIFKRSLKCHVLPKESIHPYIFIRSKKKNSSESNNALTEDEKQAKIDKSVLSKKKKLLKINKILENNNINYKLPSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYQ2</accession>
    <name>Q5CYQ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein with 5 TPR domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_1440</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628328.1">
        <property type="nucleotide sequence ID" value="XM_628326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYQ2"/>
    <dbReference type="STRING" id="353152.Q5CYQ2"/>
    <dbReference type="GeneID" id="3372246"/>
    <dbReference type="KEGG" id="cpv:cgd7_1440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1440"/>
    <dbReference type="InParanoid" id="Q5CYQ2"/>
    <dbReference type="OMA" id="ERCLYHS"/>
    <dbReference type="OrthoDB" id="659at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007192">
        <property type="entry name" value="APC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF10">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04049">
        <property type="entry name" value="ANAPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Cdc23" evidence="8">
        <location>
            <begin position="57"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="446"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="480"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="649" mass="74399" checksum="899778E178904D37" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYU6</accession>
    <name>Q5CYU6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628284.1">
        <property type="nucleotide sequence ID" value="XM_628282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYU6"/>
    <dbReference type="GeneID" id="3371993"/>
    <dbReference type="KEGG" id="cpv:cgd7_960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_960"/>
    <dbReference type="InParanoid" id="Q5CYU6"/>
    <dbReference type="OMA" id="QICNEYI"/>
    <dbReference type="OrthoDB" id="341765at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="152"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="534" mass="61717" checksum="D0629AF93645886A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPQ1</accession>
    <name>A3FPQ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Calcium-dependent protein kinase 7 (CDPK)(CPK7)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_3890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388397.1">
        <property type="nucleotide sequence ID" value="XM_001388360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPQ1"/>
    <dbReference type="SMR" id="A3FPQ1"/>
    <dbReference type="STRING" id="353152.A3FPQ1"/>
    <dbReference type="GeneID" id="3371839"/>
    <dbReference type="KEGG" id="cpv:cgd7_3890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3890"/>
    <dbReference type="InParanoid" id="A3FPQ1"/>
    <dbReference type="OMA" id="IDWFESK"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 4 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="35"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="357" mass="40790" checksum="5989D2E008F9CB0D" modified="2007-04-03" version="1">MGNNTSAIENVIQQSFGVCLNVKQYINNNNFNERYRIGGIIGTGQFAEVFYCHEKTTNHPYAMKVIYSTDEVSIDRIIEEVEIMKLLKDHQNIVSIIDSNIEHIDEDKYEVKMVLELCKGGDLYQYVLANGAMEEKIVQKIMINLLDALKFIHKNGIIHRDLKPENILIDEFFCCKIADFGLAKRCISSDSSNKVARSKSLCGSDFYLAPELVRQQEYGPEIDIWSIGVLCYVCLCGGLPFHDNRAFDLYHKIVERGVNSYLFAQPAWKNVSSAAQHFVQWLLESDPKKRPTAENALNHRWLRTSFAKQGIQTSTNPFNRAGHKNSLSIGVDSSPVTTQSYENRNHISNHVYDIYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ23</accession>
    <name>A3FQ23_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Casein kinase I</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd3_1810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="9">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388103.1">
        <property type="nucleotide sequence ID" value="XM_001388066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ23"/>
    <dbReference type="STRING" id="353152.A3FQ23"/>
    <dbReference type="GeneID" id="3374084"/>
    <dbReference type="KEGG" id="cpv:cgd3_1810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1810"/>
    <dbReference type="InParanoid" id="A3FQ23"/>
    <dbReference type="OMA" id="IFDWTFL"/>
    <dbReference type="OrthoDB" id="5800476at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14125">
        <property type="entry name" value="STKc_CK1_delta_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000538">
        <property type="entry name" value="Putative Casein kinase I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:001033">
        <property type="entry name" value="Uncharacterized protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="9"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="431" mass="47549" checksum="638859E4E969E8A7" modified="2007-04-03" version="1">MEVRVGGKYRLGRKIGSGSFGDIYLGTNVTNSEEVAIKLESVKSRHPQLLYESKLYKILAGGIGVPTVHWYGIEGDYNVMILDLLGPSLEDLFTICNRKFSLKTVLMLADQMLNRIEFVHSKNFIHRDIKPDNFLIGRGKKLNVVYIIDFGLAKKYRDPKSQAHIPYREGKNLTGTARYASINTHLGIEQSRRDDLEALGYVLMYFNRGTLPWQGLKATSKKDKYDKIMERKIATPIETLCKHHPFEFITFLNYCRALRFEDRPDYAYLRRLFKDLFFREGYQYDFIFDWSFLQPEKDRRRTGNSVGVGVGVPVGAAVANAGANGPIPTNGMGVGVTQGNIPAGQSTNVVAAGIGTATGAILPHNASLPNQAGPSQCMMPGGPSSPAGIPVAGGATQVTYTQTNANCVAGEGGQNVYHESQQDEQWGGVVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ55</accession>
    <name>A3FQ55_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dynein light chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Cytoplasm</location>
            <location evidence="1 8">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the dynein light chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388191.1">
        <property type="nucleotide sequence ID" value="XM_001388154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ55"/>
    <dbReference type="SMR" id="A3FQ55"/>
    <dbReference type="FunCoup" id="A3FQ55">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ55"/>
    <dbReference type="GeneID" id="3373428"/>
    <dbReference type="KEGG" id="cpv:cgd2_740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_740"/>
    <dbReference type="InParanoid" id="A3FQ55"/>
    <dbReference type="OMA" id="THEKGHF"/>
    <dbReference type="OrthoDB" id="10033309at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21452">
        <property type="entry name" value="DLC-like_DYNLL1_DYNLL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.740.10:FF:000001">
        <property type="entry name" value="Dynein light chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.740.10">
        <property type="entry name" value="Protein Inhibitor Of Neuronal Nitric Oxide Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037177">
        <property type="entry name" value="DLC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019763">
        <property type="entry name" value="Dynein_light_1/2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001372">
        <property type="entry name" value="Dynein_light_chain_typ-1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11886:SF35">
        <property type="entry name" value="DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01221">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01375">
        <property type="entry name" value="Dynein_light"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54648">
        <property type="entry name" value="DLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01239">
        <property type="entry name" value="DYNEIN_LIGHT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5 8" id="KW-0243">Dynein</keyword>
    <keyword evidence="4 8" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="89" mass="10265" checksum="F811E8D63AD3DC42" modified="2007-04-03" version="1">MSEKKAVIKNADMSDEMQQDAISCAAAAIERHNVEKDIAAYIKKEFDRKYNPTWHCVVGRNFGSYVTHETRHFIYFYMGQIAVLLFKSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ63</accession>
    <name>A3FQ63_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_1150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388199.1">
        <property type="nucleotide sequence ID" value="XM_001388162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ63"/>
    <dbReference type="STRING" id="353152.A3FQ63"/>
    <dbReference type="GeneID" id="3373455"/>
    <dbReference type="KEGG" id="cpv:cgd2_1150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1150"/>
    <dbReference type="InParanoid" id="A3FQ63"/>
    <dbReference type="OMA" id="HYNAVHD"/>
    <dbReference type="OrthoDB" id="8630045at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.60:FF:000264">
        <property type="entry name" value="Zinc finger protein 236"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379:SF121">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24379">
        <property type="entry name" value="KRAB AND ZINC FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00096">
        <property type="entry name" value="zf-C2H2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13894">
        <property type="entry name" value="zf-C2H2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13912">
        <property type="entry name" value="zf-C2H2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="44"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="76"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="237"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="268"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="335" mass="38299" checksum="50C53894F1F3C318" modified="2007-04-03" version="1">MSSEAVDVKSPRLFACGYPGCHASFKRRSHLERHAQTHTGIKLFKCHECSKAFGRSDHLRRHMMLVHSSIEEKASYPCSSCNSVFMSPTSLRRHIKRSHDTPYICEVCGNLFPSATSLQRHTLRQHLTAEIPFPNRTEDSNSKQCWYVCRADPMLCSAAFLSYPGLVRHIKSKHWSSSNEPQPLILNQNQCIINNENSQNQCLYALPNEANVGHNENDPLLNNTIGENKDSDIDCSYRCPYPDCGRFYSSKSNVRKHIQVSHCNSKPYECHLCPKKYGYRTPYIRHMKNSHPEFQDENIINDHCSGITTMDESHSDLTIPGTPHYPPLYVDAIPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ68</accession>
    <name>A3FQ68_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_1660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2007-04" db="PDB data bank">
            <title>Crystal structure of Cryptosporidium parvum cyclophilin type peptidyl-prolyl cis-trans isomerase cgd2_1660.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Lew J."/>
                <person name="Hills T."/>
                <person name="Hassanali A."/>
                <person name="Lin L."/>
                <person name="Wasney G."/>
                <person name="Zhao Y."/>
                <person name="Kozieradzki I."/>
                <person name="Vedadi M."/>
                <person name="Schapira M."/>
                <person name="Bochkarev A."/>
                <person name="Edwards A.M."/>
                <person name="Arrowsmith C.H."/>
                <person name="Weigelt J."/>
                <person name="Sundstrom M."/>
                <person name="Hui R."/>
                <person name="Artz J.D."/>
                <person name="Amani M."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 3-169</scope>
    </reference>
    <reference evidence="9" key="3">
        <citation type="submission" date="2007-06" db="PDB data bank">
            <title>Crystal structure of Cryptosporidium parvum cyclophilin type peptidyl-prolyl cis-trans isomerase cgd2_1660 in the presence of dipeptide ala-pro.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Lew J."/>
                <person name="Hills T."/>
                <person name="Hassanali A."/>
                <person name="Lin L."/>
                <person name="Wasney G."/>
                <person name="Zhao Y."/>
                <person name="Kozieradzki I."/>
                <person name="Vedadi M."/>
                <person name="Schapira M."/>
                <person name="Bochkarev A."/>
                <person name="Edwards A.M."/>
                <person name="Arrowsmith C.H."/>
                <person name="Weigelt J."/>
                <person name="Sundstrom M."/>
                <person name="Hui R."/>
                <person name="Artz J.D."/>
                <person name="Amani M."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.17 ANGSTROMS) OF 3-169</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 4">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388204.1">
        <property type="nucleotide sequence ID" value="XM_001388167.1"/>
    </dbReference>
    <dbReference type="PDB" id="2POE">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.01 A"/>
        <property type="chains" value="A=3-169"/>
    </dbReference>
    <dbReference type="PDB" id="2QER">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.17 A"/>
        <property type="chains" value="A=3-169"/>
    </dbReference>
    <dbReference type="PDBsum" id="2POE"/>
    <dbReference type="PDBsum" id="2QER"/>
    <dbReference type="AlphaFoldDB" id="A3FQ68"/>
    <dbReference type="SMR" id="A3FQ68"/>
    <dbReference type="FunCoup" id="A3FQ68">
        <property type="interactions" value="403"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ68"/>
    <dbReference type="GeneID" id="3373451"/>
    <dbReference type="KEGG" id="cpv:cgd2_1660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1660"/>
    <dbReference type="InParanoid" id="A3FQ68"/>
    <dbReference type="OMA" id="VPFHRVM"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="EvolutionaryTrace" id="A3FQ68"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01928">
        <property type="entry name" value="Cyclophilin_PPIL3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF2">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="2POE"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="2QER"/>
        </source>
    </evidence>
    <sequence length="169" mass="18864" checksum="35A347CE670622B1" modified="2007-04-03" version="1">MSVRIITNYGDLKFELFCSQCPKACKNFLALSASGYYKNTIFHKNIKGFIIQGGDPTGTGKGGESIYGRYFDDEIYPELKYDRRGILSMASKGASKKPNTNGSQFFITYSSLPQLNGEYVIFGKLIDGFETLNTLENCPSDKSHKPIDEIIIKDIVIHSNPIADQEILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQC5</accession>
    <name>A3FQC5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388147.1">
        <property type="nucleotide sequence ID" value="XM_001388110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQC5"/>
    <dbReference type="FunCoup" id="A3FQC5">
        <property type="interactions" value="156"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQC5"/>
    <dbReference type="GeneID" id="3371495"/>
    <dbReference type="KEGG" id="cpv:cgd1_860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_860"/>
    <dbReference type="InParanoid" id="A3FQC5"/>
    <dbReference type="OMA" id="GMSLEMQ"/>
    <dbReference type="OrthoDB" id="3881at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01791">
        <property type="entry name" value="Ubl_UBL5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000054">
        <property type="entry name" value="Ubiquitin-like protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039732">
        <property type="entry name" value="Hub1/Ubl5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13042">
        <property type="entry name" value="UBIQUITIN-LIKE PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="2"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="73" mass="8675" checksum="D9E40E385CCA5A2D" modified="2007-04-03" version="1" fragment="single">MIEVVLNDRLGKKIRVKCNPDDTIGDLKKLVAEVTGTRWDKIRIQKWYNVYKDHITLEDYEIKDGMGLELYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQD0</accession>
    <name>A3FQD0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Developmental protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_1320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388152.1">
        <property type="nucleotide sequence ID" value="XM_001388115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQD0"/>
    <dbReference type="FunCoup" id="A3FQD0">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQD0"/>
    <dbReference type="GeneID" id="3371490"/>
    <dbReference type="KEGG" id="cpv:cgd1_1320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1320"/>
    <dbReference type="InParanoid" id="A3FQD0"/>
    <dbReference type="OMA" id="QQITMVM"/>
    <dbReference type="OrthoDB" id="10266568at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAZ51329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="188" mass="21545" checksum="50BB51A48B6BE091" modified="2007-04-03" version="1">MGNRISIDDSIFELKLQKKELERQYNKRDRDSKSERKKAKDAIISGKADLSKIYAENSLRMQEECKELLIMISKLDRLCARLEKASSKEKISTQLLDIMPKLKKQLSEEGVMGYSNMGKIKEIGQLLNTIEDSQPETVGENVGKEKCMHAEDSVERLLDELLNEHAMEIDLAISSKTEINELLEEKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQD9</accession>
    <name>A3FQD9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd1_2100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388161.1">
        <property type="nucleotide sequence ID" value="XM_001388124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQD9"/>
    <dbReference type="STRING" id="353152.A3FQD9"/>
    <dbReference type="GeneID" id="3371408"/>
    <dbReference type="KEGG" id="cpv:cgd1_2100"/>
    <dbReference type="InParanoid" id="A3FQD9"/>
    <dbReference type="OMA" id="NENARGH"/>
    <dbReference type="OrthoDB" id="1689333at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042283">
        <property type="term" value="F:dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF2">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE GLC1MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="149"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="205"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="252"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="282"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="349" mass="40984" checksum="7B022005DF17E833" modified="2007-04-03" version="1">MGILLLSIYLTANYPIYSAIIFTCLVFTKHFFIVLAPIWFIFLLNSCIQRSEGKFFILIISSFKVLFSVLSVSAFAITPIIFYGQLNQFISRLFPISRSFIHFIPASNLYTLYSIADKVFAKFNLNFCKIHHLDAEGHYIKSMKCIPPVKPIFCMLICILFIIPVLVRLWHSLSNIKESTKSILITSSISLLIAFQFGFHIHEKQILYAIIPLGIYTILFCENDQQLLAHYTYLSNWSNLSVMVLLETYPENIIKYVIIMTYYVLELLLLNINLRKYSVHNILFIFGLTTIFFLEFFVQRLVFDKLQLVFIYHALSSLICIFPILYYTFYFYYFWVFDSIKNSNRQESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQF2</accession>
    <name>A3FQF2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_2850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388174.1">
        <property type="nucleotide sequence ID" value="XM_001388137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQF2"/>
    <dbReference type="STRING" id="353152.A3FQF2"/>
    <dbReference type="GeneID" id="3371395"/>
    <dbReference type="KEGG" id="cpv:cgd1_2850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2850"/>
    <dbReference type="InParanoid" id="A3FQF2"/>
    <dbReference type="OMA" id="NTILEHN"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="836"/>
            <end position="1121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="674"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="815"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="815"/>
            <end position="830"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1155" mass="127210" checksum="19F474C4235EAD9D" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQL2</accession>
    <name>A3FQL2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glycerophosphodiester phosphodiesterase</fullName>
            <ecNumber evidence="2">3.1.4.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd4_2590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a sn-glycero-3-phosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12969"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:83408"/>
            <dbReference type="EC" id="3.1.4.46"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.46" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388067.1">
        <property type="nucleotide sequence ID" value="XM_001388030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQL2"/>
    <dbReference type="STRING" id="353152.A3FQL2"/>
    <dbReference type="GeneID" id="3372823"/>
    <dbReference type="KEGG" id="cpv:cgd4_2590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2590"/>
    <dbReference type="InParanoid" id="A3FQL2"/>
    <dbReference type="OMA" id="ARHEPNI"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008889">
        <property type="term" value="F:glycerophosphodiester phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620:SF7">
        <property type="entry name" value="GLYCEROPHOSPHODIESTER PHOSPHODIESTERASE GDPD5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43620">
        <property type="entry name" value="GLYCEROPHOSPHORYL DIESTER PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002652587" description="glycerophosphodiester phosphodiesterase" evidence="7">
        <location>
            <begin position="18"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="8">
        <location>
            <begin position="19"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="348" mass="40054" checksum="157BE49A19C0A7DC" modified="2007-04-03" version="1">MPGIYLIIFYMMVRAKASLHLVAHRGASYFVPEESLAAYSLAAKHGVNFIECDVVSTKDGVLILRHSPNLSESTNIDDLIEFSHLRRTEILYDNNSNDAITGIFSWDLTYEEIKRIKCTHEKKYNNRNPSLNGIYDILTLDEFLKFSVSGFDGNFPGLYIEIKYPTLHERKGIDNITDKLLDALDRFGINKKTDAVYIQSFEPSNLEYIRARSEVNLVQLLTRDSENNFVYAIEDVENGGQMKYVTCDIEYISKFANVVSPYKEDLIDRTSTSNNTLPSSSHFVSKAHELGLIVVPYTFRPESILSYFKDIYEEYDYFIKTLKADGLFTDDSESIMQYVNNTYTRLYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQP8</accession>
    <name>A3FQP8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosomal RNA-processing protein 42</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAZ51222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388417.1">
        <property type="nucleotide sequence ID" value="XM_001388380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQP8"/>
    <dbReference type="FunCoup" id="A3FQP8">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQP8"/>
    <dbReference type="GeneID" id="3372480"/>
    <dbReference type="KEGG" id="cpv:cgd8_340"/>
    <dbReference type="InParanoid" id="A3FQP8"/>
    <dbReference type="OrthoDB" id="272245at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0271">Exosome</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="72"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="8">
        <location>
            <begin position="45"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00042523"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="295" mass="33121" checksum="2D84EF683498AD5B" modified="2007-04-03" version="1">MNSFRLGIYCDFLKSMTKSISDSEKLFLEDGVDQGIRNDGRDLTDFRPIVIALDVISTANGSSRIRNDELDIIVAVKVSFLNNLFFFIIALILFSSNIMDKISNVAPSFTEEDYSFYITNIVKDMCFKNFDLSKLTILENKLYWNIYIDATILSFGGNMVDWVTIAIHTALRTTRIPKIHVSPSISTKENNKDVSYTVSPSVCSGTPFPFQDIPFIISAGCIRGKVIWDMNMQEQICSKTIIALSINSKGECVAMNKVYSNTLDLNLIPTIINKAAEISSEISKSLDEFFSNKQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPD9</accession>
    <name>Q5CPD9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Asparagine synthetase A (AsnA) like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_4540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000018">
        <property type="protein sequence ID" value="EAK87293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625302.1">
        <property type="nucleotide sequence ID" value="XM_625302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPD9"/>
    <dbReference type="SMR" id="Q5CPD9"/>
    <dbReference type="STRING" id="353152.Q5CPD9"/>
    <dbReference type="GeneID" id="3372306"/>
    <dbReference type="KEGG" id="cpv:cgd5_4540"/>
    <dbReference type="InParanoid" id="Q5CPD9"/>
    <dbReference type="OMA" id="QSRICMF"/>
    <dbReference type="OrthoDB" id="396916at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004071">
        <property type="term" value="F:aspartate-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004618">
        <property type="entry name" value="AsnA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30073">
        <property type="entry name" value="ASPARTATE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30073:SF5">
        <property type="entry name" value="ASPARTATE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03590">
        <property type="entry name" value="AsnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001555">
        <property type="entry name" value="Asp_ammon_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="7">
        <location>
            <begin position="26"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="343" mass="40448" checksum="970403708ACD18F2" modified="2005-04-12" version="1" fragment="single">NNIIIIKMEVKKQSQFKTVLADIEFIKITFQQLLKESLDLIRISAPLFLEKESGLNDDLSGYEEKVSFTFNNKVLEIVQSLAKWKRYALKKYELNGLYADMNAIRKSEELDNLHSIYVDQWDWEMVIDTNKGKTKDEILVDIARIIHNNIYNLERLYWNMKKEKQDIVNIPNENEMIKKELYIISSEELLNMYPNLSSNDREREICKKYGSVFIKQIGKKLSNNTVHDLRAPDYDDWEYNGDLIYWSNILNGPIELSSMGVRVNKESLIKQLEICNSTERLKLPYCKMLLNNELPETIGGGIGQSRLCMLILRKEHISQVQCSYWDEKGDYRRYFIIFLKKIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPE7</accession>
    <name>Q5CPE7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Telomeric insulinase-like protease with signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_5510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Iowa type II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000016">
        <property type="protein sequence ID" value="EAK87303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625315.1">
        <property type="nucleotide sequence ID" value="XM_625315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPE7"/>
    <dbReference type="STRING" id="353152.Q5CPE7"/>
    <dbReference type="GeneID" id="3375632"/>
    <dbReference type="KEGG" id="cpv:cgd6_5510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5510"/>
    <dbReference type="InParanoid" id="Q5CPE7"/>
    <dbReference type="OrthoDB" id="10375435at2759"/>
    <dbReference type="BRENDA" id="3.4.24.56">
        <property type="organism ID" value="1728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="490" mass="58390" checksum="D50A9565667AA81A" modified="2005-04-12" version="1">MMTFIFFSLKKSQFIYLYTKIIQILIKKQYNLVKSNDISRFTIDLNFFSIDTWAPLSLTIGIDSNSYNIADYELNKISKILNNLISTDEESFNDAIKEIKYEIISSQNNQIKNIYISLYNQLFYNQDQSNSKLLKSINELSYVDFIELVIFYFKKFNLKGVFVGNIHPINATRTLEHFLSDFLPEKEQESIFTYIWNIIKAIFTRRRWSSNSKSYSMYAKVISRIFDLDLLPDPLISEKYIQNDDDKLKNIQILDPLSLNNRSKFFIFMQRNSSFETINGVYLDVFIGNNSIKNQVNSQVLQSIICSQLDEVFYNENNIAYKVNFEINTHAESVVARINIQSREHIQILSENILQFWKSYFHPNSTYITPEIFEKSKKSVEAIYINFEFIKDIAYDFNYKILKKNISGHFNSWLSIEFLSFKKFMEWFEQIYFNSVLFLYAIQTNHHENKLDQIQKYLPFNFTRLDHTKKSLFEIEEIKTYSQLKFMKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPE9</accession>
    <name>Q5CPE9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_5490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000016">
        <property type="protein sequence ID" value="EAK87300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625313.1">
        <property type="nucleotide sequence ID" value="XM_625313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPE9"/>
    <dbReference type="STRING" id="353152.Q5CPE9"/>
    <dbReference type="GeneID" id="3375629"/>
    <dbReference type="KEGG" id="cpv:cgd6_5490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5490"/>
    <dbReference type="InParanoid" id="Q5CPE9"/>
    <dbReference type="OrthoDB" id="10628270at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254076" evidence="2">
        <location>
            <begin position="24"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="41"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="234" mass="27400" checksum="A1DDB698B89299AE" modified="2005-04-12" version="1">MFIKSKILLLFIYFMFLFENVTDDFLVKKEISLIKIRNEIPNEGSSSSGNNNSEGLSRGGKKPVLRSMRTLPLKGSEKSLHCHHRHHHKDKHCHGKKKHIVHQHIPSKPKGKNTIRLLRALRMKDPDDPEQNPSDMPSDEPHHSDDEEELCDDDDDDDDDDDEICDDEEEEKRQKEKEREEMENKHDQIDSGRKRQHKRKVRKNKNKSRPRGSGKHFSEKICGPCKNINMEDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPH1</accession>
    <name>Q5CPH1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 9">Adenosylhomocysteinase</fullName>
            <ecNumber evidence="6 9">3.13.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd3_80</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2016-01" db="PDB data bank">
            <title>2.85 Angstrom Crystal Structure of S-adenosylhomocysteinase from Cryptosporidium parvum in Complex with Adenosine and NAD.</title>
            <authorList>
                <consortium name="Center for Structural Genomics of Infectious Diseases (CSGID)"/>
                <person name="Minasov G."/>
                <person name="Shuvalova L."/>
                <person name="Halavaty A."/>
                <person name="Kiryukhina O."/>
                <person name="Dubrovska I."/>
                <person name="Bishop B."/>
                <person name="Kwon K."/>
                <person name="Anderson W.F."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.85 ANGSTROMS) IN COMPLEX WITH NAD(+) AND ADENOSINE</scope>
    </reference>
    <reference evidence="15" key="3">
        <citation type="submission" date="2016-05" db="PDB data bank">
            <title>2.15 Angstrom Crystal Structure of S-adenosylhomocysteinase from Cryptosporidium parvum in Complex with D-Eritadenine and NAD.</title>
            <authorList>
                <consortium name="Center for Structural Genomics of Infectious Diseases (CSGID)"/>
                <person name="Minasov G."/>
                <person name="Shuvalova L."/>
                <person name="Kiryukhina O."/>
                <person name="Dubrovska I."/>
                <person name="Bishop B."/>
                <person name="Kwon K."/>
                <person name="Anderson W.F."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) IN COMPLEX WITH NAD(+)</scope>
    </reference>
    <reference evidence="16" key="4">
        <citation type="submission" date="2016-05" db="PDB data bank">
            <title>2.25 Angstrom Crystal Structure of S-adenosylhomocysteinase from Cryptosporidium parvum in Complex with Neplanocin-A and NAD.</title>
            <authorList>
                <consortium name="Center for Structural Genomics of Infectious Diseases (CSGID)"/>
                <person name="Minasov G."/>
                <person name="Shuvalova L."/>
                <person name="Kiryukhina O."/>
                <person name="Dubrovska I."/>
                <person name="Bishop B."/>
                <person name="Kwon K."/>
                <person name="Anderson W.F."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) IN COMPLEX WITH NAD(+)</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <reference evidence="17" key="5">
        <citation type="submission" date="2016-09" db="PDB data bank">
            <title>1.95 Angstrom Crystal Structure of S-adenosylhomocysteinase from Cryptosporidium parvum in Complex with Adenine and NAD.</title>
            <authorList>
                <consortium name="Center for Structural Genomics of Infectious Diseases (CSGID)"/>
                <person name="Minasov G."/>
                <person name="Shuvalova L."/>
                <person name="Kiryukhina O."/>
                <person name="Dubrovska I."/>
                <person name="Bishop B."/>
                <person name="Kwon K."/>
                <person name="Anderson W.F."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) IN COMPLEX WITH NAD(+) AND ADENINE</scope>
    </reference>
    <reference evidence="19" key="6">
        <citation type="submission" date="2016-10" db="PDB data bank">
            <title>2.4 Angstrom Crystal Structure of S-adenosylhomocysteinase from Cryptosporidium parvum in Complex with DZ2002 and NAD.</title>
            <authorList>
                <consortium name="Center for Structural Genomics of Infectious Diseases (CSGID)"/>
                <person name="Minasov G."/>
                <person name="Shuvalova L."/>
                <person name="Kiryukhina O."/>
                <person name="Dubrovska I."/>
                <person name="Bishop B."/>
                <person name="Kwon K."/>
                <person name="Anderson W.F."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) IN COMPLEX WITH NAD(+)</scope>
    </reference>
    <reference evidence="18" key="7">
        <citation type="submission" date="2016-10" db="PDB data bank">
            <title>2.6 Angstrom Crystal Structure of S-adenosylhomocysteinase from Cryptosporidium parvum in Complex with Aristeromycin and NAD.</title>
            <authorList>
                <consortium name="Center for Structural Genomics of Infectious Diseases (CSGID)"/>
                <person name="Minasov G."/>
                <person name="Shuvalova L."/>
                <person name="Kiryukhina O."/>
                <person name="Dubrovska I."/>
                <person name="Bishop B."/>
                <person name="Kwon K."/>
                <person name="Anderson W.F."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) IN COMPLEX WITH NAD(+)</scope>
    </reference>
    <reference evidence="20" key="8">
        <citation type="submission" date="2017-02" db="PDB data bank">
            <title>2.65 Angstrom Resolution Crystal Structure of S-adenosylhomocysteinase from Cryptosporidium parvum in Complex with SAH and NAD.</title>
            <authorList>
                <consortium name="Center for Structural Genomics of Infectious Diseases (CSGID)"/>
                <person name="Minasov G."/>
                <person name="Shuvalova L."/>
                <person name="Dubrovska I."/>
                <person name="Winsor J."/>
                <person name="Stam J."/>
                <person name="Kwon K."/>
                <person name="Anderson W.F."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) IN COMPLEX WITH NAD(+); S-ADENOSYL-L-HOMOCYSTEINE AND ADENOSINE</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine</text>
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            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:58199"/>
            <dbReference type="EC" id="3.13.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8 9">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
        <text evidence="8 9">Binds 1 NAD(+) per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 9">Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the adenosylhomocysteinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.13.2.1" evidence="6 9"/>
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        <property type="protein sequence ID" value="EAK87329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_625322.1"/>
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    <dbReference type="PDB" id="5HM8">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.85 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H=1-495"/>
    </dbReference>
    <dbReference type="PDB" id="5JPI">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="A/B/C/D=1-495"/>
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    <dbReference type="PDB" id="5JXW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.25 A"/>
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    <dbReference type="PDB" id="5T8K">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="A/B/C/D=1-495"/>
    </dbReference>
    <dbReference type="PDB" id="5TJ9">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.60 A"/>
        <property type="chains" value="A/B/C/D=1-495"/>
    </dbReference>
    <dbReference type="PDB" id="5TLS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="A/B/C/D=1-495"/>
    </dbReference>
    <dbReference type="PDB" id="5UTU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.65 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H=1-495"/>
    </dbReference>
    <dbReference type="PDBsum" id="5HM8"/>
    <dbReference type="PDBsum" id="5JPI"/>
    <dbReference type="PDBsum" id="5JXW"/>
    <dbReference type="PDBsum" id="5T8K"/>
    <dbReference type="PDBsum" id="5TJ9"/>
    <dbReference type="PDBsum" id="5TLS"/>
    <dbReference type="PDBsum" id="5UTU"/>
    <dbReference type="AlphaFoldDB" id="Q5CPH1"/>
    <dbReference type="SMR" id="Q5CPH1"/>
    <dbReference type="FunCoup" id="Q5CPH1">
        <property type="interactions" value="190"/>
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    <dbReference type="STRING" id="353152.Q5CPH1"/>
    <dbReference type="GeneID" id="3372325"/>
    <dbReference type="KEGG" id="cpv:cgd3_80"/>
    <dbReference type="InParanoid" id="Q5CPH1"/>
    <dbReference type="OMA" id="YIGVTVE"/>
    <dbReference type="OrthoDB" id="10007170at2759"/>
    <dbReference type="UniPathway" id="UPA00314">
        <property type="reaction ID" value="UER00076"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="Q5CPH1"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0004013">
        <property type="term" value="F:adenosylhomocysteinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033353">
        <property type="term" value="P:S-adenosylmethionine cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00401">
        <property type="entry name" value="SAHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000004">
        <property type="entry name" value="Adenosylhomocysteinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1480">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
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    <dbReference type="InterPro" id="IPR042172">
        <property type="entry name" value="Adenosylhomocyst_ase-like_sf"/>
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    <dbReference type="InterPro" id="IPR000043">
        <property type="entry name" value="Adenosylhomocysteinase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015878">
        <property type="entry name" value="Ado_hCys_hydrolase_NAD-bd"/>
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    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
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    <dbReference type="InterPro" id="IPR020082">
        <property type="entry name" value="S-Ado-L-homoCys_hydrolase_CS"/>
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    <dbReference type="NCBIfam" id="TIGR00936">
        <property type="entry name" value="ahcY"/>
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    <dbReference type="NCBIfam" id="NF004005">
        <property type="entry name" value="PRK05476.2-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR23420:SF0">
        <property type="entry name" value="ADENOSYLHOMOCYSTEINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05221">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00670">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001109">
        <property type="entry name" value="Ad_hcy_hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00996">
        <property type="entry name" value="AdoHcyase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00997">
        <property type="entry name" value="AdoHcyase_NAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00738">
        <property type="entry name" value="ADOHCYASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00739">
        <property type="entry name" value="ADOHCYASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14 15 16" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 8 9" id="KW-0520">NAD</keyword>
    <keyword evidence="14 15 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 9" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S-adenosyl-L-homocysteine hydrolase NAD binding" evidence="11">
        <location>
            <begin position="246"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="53"/>
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        <ligand>
            <name>adenosine</name>
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            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
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        <ligand>
            <name>adenosine</name>
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    <feature type="binding site" evidence="20">
        <location>
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        <ligand>
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    <feature type="binding site" evidence="17">
        <location>
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        </location>
        <ligand>
            <name>adenine</name>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
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        <ligand>
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    <feature type="binding site" evidence="14">
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        <ligand>
            <name>adenosine</name>
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        </ligand>
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    <feature type="binding site" evidence="20">
        <location>
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        <ligand>
            <name>adenosine</name>
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    <feature type="binding site" evidence="7">
        <location>
            <position position="55"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-homocysteine</name>
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        </ligand>
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    <feature type="binding site" evidence="17">
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        <ligand>
            <name>adenine</name>
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        <ligand>
            <name>S-adenosyl-L-homocysteine</name>
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        <ligand>
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        <ligand>
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        <ligand>
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        <ligand>
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        <ligand>
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            <end position="214"/>
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        <ligand>
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        <ligand>
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        <ligand>
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        <ligand>
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        <ligand>
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    <feature type="binding site" evidence="20">
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        <ligand>
            <name>adenosine</name>
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    <feature type="binding site" evidence="20">
        <location>
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        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
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        </ligand>
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    <feature type="binding site" evidence="14">
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        <ligand>
            <name>adenosine</name>
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            <label>1</label>
        </ligand>
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    <feature type="binding site" evidence="7">
        <location>
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        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15 16">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="277"/>
            <end position="282"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15 16">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15 16">
        <location>
            <position position="279"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 14 15">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15 16">
        <location>
            <position position="333"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="354"/>
            <end position="356"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15 16">
        <location>
            <position position="354"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15 16">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="357"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 14 15">
        <location>
            <position position="403"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>adenine</name>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-homocysteine</name>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>adenine</name>
            <dbReference type="ChEBI" id="CHEBI:16708"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="410"/>
        </location>
        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15 16">
        <location>
            <position position="489"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14 15 16">
        <location>
            <position position="493"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" evidence="16">
        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR001109-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000548"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK87329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="5HM8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="5JPI"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="5JXW"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="5T8K"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="5TJ9"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="5TLS"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="5UTU"/>
        </source>
    </evidence>
    <sequence length="495" mass="55858" checksum="B463655B2216A27B" modified="2005-04-12" version="1" fragment="single">YKMESRIKDISLAEFGLQDMEIAKTDMMGLVELQRKYRDSKPLKGARITGSLHLTIETSVLVETLYELGAEIRWCSCNIYSTQDHAAAALVKKNIATVFAWKNETIEDYWVCLNDAMTWRNPNDKDKICGPNLIVDDGGDATLILHEGVKAEIEYEKYNKIPEYLETELDENGKQLSMDLKCMYKVLKMELLKNPFRWRGMLKDLYGVSEETTTGVLRLKIMESEGKLLLPAINVNDSVTKSKFDNTYGCRQSLLHGLFNGCIQMLAGKKIVVLGYGEVGKGCAQGLSGVGARVIVTEIDPICALQASMEGYQVSVLEDVVSEADIFITATGNKDVITVEHMRKMKENAYIANIGHFDDEIDVYGLENYPGIKVIEVKQNVHKFTFPDTQKSVILLCKGRLVNLGCATGHPPLVMSMSFTNQVLAQMDLWKSRELVDRSKNTRFFVKKLSKELDEYVARLHLDVLGIKLTKLTETQAKYINVSINGPYKSEDYRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPJ4</accession>
    <name>Q5CPJ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Synaptobrevin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625355.1">
        <property type="nucleotide sequence ID" value="XM_625355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPJ4"/>
    <dbReference type="GeneID" id="3375636"/>
    <dbReference type="KEGG" id="cpv:cgd6_150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_150"/>
    <dbReference type="InParanoid" id="Q5CPJ4"/>
    <dbReference type="OrthoDB" id="337525at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="294" mass="33943" checksum="22C6A96FD0FD1321" modified="2007-04-03" version="1">MSVQSNELDQEAQQYNLYKDLEEFEKKLATARKRTRDADYLDRKLVISDSTEFERHFDNLSEAIARLLPYHTFYVDEIKSNRISEDPDKISERNKRIKNLEDSILNISTSSPSFIFNTCKYGFVRVIHSSISMDLERNKKELAQLQALELTWKYPIENSSNFPNDKNMIGGSSVLTGSTLNNSNHLSTTHFDHSNELLYRNMVPKNQVNSQVSNMIGNYSMNKHYFDTNEILGREKDKDLLPNSVPNSNQISHNPNLESVYLTKINGNANKNLDLYSLPPDMLKTERFSNISNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPJ8</accession>
    <name>Q5CPJ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Conserved protein with signal peptide and transmembrane domain or GPI anchor signal near C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd6_110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the malectin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625351.1">
        <property type="nucleotide sequence ID" value="XM_625351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPJ8"/>
    <dbReference type="SMR" id="Q5CPJ8"/>
    <dbReference type="STRING" id="353152.Q5CPJ8"/>
    <dbReference type="GeneID" id="3375669"/>
    <dbReference type="KEGG" id="cpv:cgd6_110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_110"/>
    <dbReference type="InParanoid" id="Q5CPJ8"/>
    <dbReference type="OMA" id="VLAEHCW"/>
    <dbReference type="OrthoDB" id="10013439at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.430">
        <property type="entry name" value="Galactose-binding lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021720">
        <property type="entry name" value="Malectin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039155">
        <property type="entry name" value="MLEC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13460:SF0">
        <property type="entry name" value="MALECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11721">
        <property type="entry name" value="Malectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254079" evidence="11">
        <location>
            <begin position="27"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Malectin" evidence="12">
        <location>
            <begin position="28"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK87338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="289" mass="32822" checksum="BA38C958E11376ED" modified="2007-04-03" version="1">MLVQMKQVSFVLLFCLFFYQLDKLHAEVIYAVNCGGPRYFSKSENILYEEDNGYNGGISTDSGKQLSPFPYVEDDFVYLSERYSTDRTLQYMLNLNKLTPGVFTIVLKFSEIHFKEPGKKVFSIAVGNVIFKQSFDIYKEVGFGVPMEEYIECTFDGENISLNGMNITQGYSKEEKLLILAMFKQEDNPKINAIVVYKGSKDEIPKIQRPKPKLSVESILQKINKEGQKPDIINNQIYLIDEPLFTVKELTVTDSLYNLISTIPGIIISLIISVATLRIGVILSSHLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPQ2</accession>
    <name>Q5CPQ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted, membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_4480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625462.1">
        <property type="nucleotide sequence ID" value="XM_625462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPQ2"/>
    <dbReference type="GeneID" id="3372438"/>
    <dbReference type="KEGG" id="cpv:cgd4_4480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4480"/>
    <dbReference type="InParanoid" id="Q5CPQ2"/>
    <dbReference type="OrthoDB" id="342173at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254363" evidence="1">
        <location>
            <begin position="26"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="409" mass="47948" checksum="9CDFB9DEE2D1C738" modified="2005-04-12" version="1">MKAIKLCFIVLLSIILLHSFDFVRSEAPNEFTLEEQDEPTTSTSTGLSILEETRVKLLSEEFIILEMEFFDLQLKNLLGSEFWLDLHKMEHYKDIIRAILKYWKHFSDPNHKIHQENVVRFYVSNQKEMRKDLLSDYSRYRESSAAMVTKFVKNVTKYSCYRMKNTLVLFYLIFSSEPEYLVSAFLLYLLICSFRELAFSSFSTSFVKVMKNEDQLGSKMIVLGGSLVSRLIFSIQRVCFQYNKVQYPISAENQMIRNPINTQTFILEEFGLQFCLSLLELAANEEVIIDFKYLLLFFGSRMELAAEVLLAFDILKEAIRLATYLTEAISLLLNDNNAFQTIVTKIMDLYGINIWDIKKRFNECILVKEKYPVLNGIVSTTDYQKKARKRSRSRTEKSKISLRSKYSFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPS6</accession>
    <name>Q5CPS6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_4220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625438.1">
        <property type="nucleotide sequence ID" value="XM_625438.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372398"/>
    <dbReference type="KEGG" id="cpv:cgd4_4220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4220"/>
    <dbReference type="InParanoid" id="Q5CPS6"/>
    <dbReference type="OMA" id="VKYNYCL"/>
    <dbReference type="OrthoDB" id="342817at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1714" mass="200282" checksum="70D1AA237579A1D3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPY8</accession>
    <name>Q5CPY8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Apcomplexan conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625491.1">
        <property type="nucleotide sequence ID" value="XM_625491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPY8"/>
    <dbReference type="GeneID" id="3372509"/>
    <dbReference type="KEGG" id="cpv:cgd8_280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_280"/>
    <dbReference type="InParanoid" id="Q5CPY8"/>
    <dbReference type="OrthoDB" id="374157at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="521" mass="61465" checksum="DD03E178A0540B83" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ44</accession>
    <name>Q5CQ44_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Transcription initiation factor IIA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_4200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625582.1">
        <property type="nucleotide sequence ID" value="XM_625582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ44"/>
    <dbReference type="GeneID" id="3372566"/>
    <dbReference type="KEGG" id="cpv:cgd5_4200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4200"/>
    <dbReference type="InParanoid" id="Q5CQ44"/>
    <dbReference type="OMA" id="YWININI"/>
    <dbReference type="OrthoDB" id="337751at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.190">
        <property type="entry name" value="Transcription factor IIA gamma subunit, alpha-helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009083">
        <property type="entry name" value="TFIIA_a-hlx"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="111" mass="12624" checksum="CD1AD68015B8A86B" modified="2005-04-12" version="1">MEGADFSEWLELNIGKSFVVLLNEFVNDRRISPSQSTKMIENYIESCSEILKKHVKSGRKLKCEGAISHYNCIDGKWDLVIKDLVIFGKSLGRVKSKYVKVSGKEVKKTIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ51</accession>
    <name>Q5CQ51_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_4120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625575.1">
        <property type="nucleotide sequence ID" value="XM_625575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ51"/>
    <dbReference type="GeneID" id="3372527"/>
    <dbReference type="KEGG" id="cpv:cgd5_4120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4120"/>
    <dbReference type="InParanoid" id="Q5CQ51"/>
    <dbReference type="OMA" id="ICELNYP"/>
    <dbReference type="OrthoDB" id="342446at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="196" mass="23199" checksum="768A7910A0E0EE80" modified="2005-04-12" version="1">MYYTIIFLILFELFLSYFLEHIIKLLKIHKLINGETNQIINSEISQLEEELKELNKPSTFTEYVKKSRQLNILKQTLNNNSTKEINQTNHKNFNFTKKIMGGIYLILKIINFLPPKIRQLLTFYIVKSYVNNHSIIIPFNQKLYSPFFQSKEKANNINSFLSYGLICTLTDLIKALIKNSLYFNMNYIQTFSSKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQA7</accession>
    <name>Q5CQA7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_1450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625741.1">
        <property type="nucleotide sequence ID" value="XM_625741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQA7"/>
    <dbReference type="STRING" id="353152.Q5CQA7"/>
    <dbReference type="GeneID" id="3372707"/>
    <dbReference type="KEGG" id="cpv:cgd4_1450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1450"/>
    <dbReference type="InParanoid" id="Q5CQA7"/>
    <dbReference type="OMA" id="ELCPCEN"/>
    <dbReference type="OrthoDB" id="343340at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="430"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="619"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="311"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="756"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="898" mass="100324" checksum="F39CCDA60B98C9C6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQH5</accession>
    <name>Q5CQH5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">pyruvate dehydrogenase (NADP(+))</fullName>
            <ecNumber evidence="16">1.2.1.51</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="17">Pyruvate:NADP(+) oxidoreductase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">cgd4_690</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>pyruvate + NADP(+) + CoA = acetyl-CoA + CO2 + NADPH</text>
            <dbReference type="Rhea" id="RHEA:17425"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.51"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="15">In the N-terminal section; belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.51" evidence="16"/>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625673.1">
        <property type="nucleotide sequence ID" value="XM_625673.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CQH5"/>
    <dbReference type="STRING" id="353152.Q5CQH5"/>
    <dbReference type="GeneID" id="3372747"/>
    <dbReference type="KEGG" id="cpv:cgd4_690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_690"/>
    <dbReference type="InParanoid" id="Q5CQH5"/>
    <dbReference type="OMA" id="NTVMQVC"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050243">
        <property type="term" value="F:pyruvate dehydrogenase (NADP+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022900">
        <property type="term" value="P:electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06207">
        <property type="entry name" value="CyPoR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03377">
        <property type="entry name" value="TPP_PFOR_PNO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07034">
        <property type="entry name" value="TPP_PYR_PFOR_IOR-alpha_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.360:FF:000088">
        <property type="entry name" value="Pyruvate dehydrogenase [NADP(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.20:FF:000022">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.920:FF:000007">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000012">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000041">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.920.10:FF:000001">
        <property type="entry name" value="Pyruvate:ferredoxin (Flavodoxin) oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.920.10">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.780.10">
        <property type="entry name" value="Pyruvate-flavodoxin oxidoreductase, EKR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017927">
        <property type="entry name" value="FAD-bd_FR_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033412">
        <property type="entry name" value="PFOR_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050722">
        <property type="entry name" value="Pyruvate:ferred/Flavod_OxRd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037112">
        <property type="entry name" value="Pyrv-flavodox_OxR_EKR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019456">
        <property type="entry name" value="Pyrv-flavodox_OxRtase_EKR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019752">
        <property type="entry name" value="Pyrv/ketoisovalerate_OxRed_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002880">
        <property type="entry name" value="Pyrv_Fd/Flavodoxin_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011895">
        <property type="entry name" value="Pyrv_flavodox_OxRed"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002869">
        <property type="entry name" value="Pyrv_flavodox_OxRed_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009014">
        <property type="entry name" value="Transketo_C/PFOR_II"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02176">
        <property type="entry name" value="pyruv_ox_red"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32154">
        <property type="entry name" value="PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32154:SF0">
        <property type="entry name" value="PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10371">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12838">
        <property type="entry name" value="Fer4_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17147">
        <property type="entry name" value="PFOR_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01558">
        <property type="entry name" value="POR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01855">
        <property type="entry name" value="POR_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00890">
        <property type="entry name" value="EKR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53323">
        <property type="entry name" value="Pyruvate-ferredoxin oxidoreductase, PFOR, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52922">
        <property type="entry name" value="TK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51384">
        <property type="entry name" value="FAD_FR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0274">FAD</keyword>
    <keyword evidence="5" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0288">FMN</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0521">NADP</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="19">
        <location>
            <begin position="710"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="19">
        <location>
            <begin position="767"/>
            <end position="796"/>
        </location>
    </feature>
    <feature type="domain" description="Flavodoxin-like" evidence="18">
        <location>
            <begin position="1288"/>
            <end position="1438"/>
        </location>
    </feature>
    <feature type="domain" description="FAD-binding FR-type" evidence="20">
        <location>
            <begin position="1501"/>
            <end position="1759"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00053024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00061065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00067011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00076877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EAK87662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1934" mass="217557" checksum="1E76544066EF96A2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQX7</accession>
    <name>Q5CQX7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Polyketide synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd4_2900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625875.1">
        <property type="nucleotide sequence ID" value="XM_625875.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQX7"/>
    <dbReference type="GeneID" id="3372998"/>
    <dbReference type="KEGG" id="cpv:cgd4_2900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2900"/>
    <dbReference type="InParanoid" id="Q5CQX7"/>
    <dbReference type="OMA" id="TWQSWFA"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002364">
        <property type="entry name" value="Quin_OxRdtase/zeta-crystal_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01746">
        <property type="entry name" value="Thioester-redct"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01162">
        <property type="entry name" value="QOR_ZETA_CRYSTAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="741"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="836"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="1308"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="2658"/>
            <end position="2733"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="2775"/>
            <end position="3203"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="3229"/>
            <end position="3575"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="4395"/>
            <end position="4472"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="4492"/>
            <end position="4918"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="5292"/>
            <end position="5621"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="6313"/>
            <end position="6389"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="6437"/>
            <end position="6861"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="7587"/>
            <end position="7662"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="7682"/>
            <end position="8097"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="9103"/>
            <end position="9179"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="9">
        <location>
            <begin position="9200"/>
            <end position="9635"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="10">
        <location>
            <begin position="9682"/>
            <end position="10001"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="10845"/>
            <end position="10927"/>
        </location>
    </feature>
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        <location>
            <begin position="10949"/>
            <end position="11383"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="8">
        <location>
            <begin position="12560"/>
            <end position="12639"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1308"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1484"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="3229"/>
            <end position="3392"/>
        </location>
    </feature>
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        <location>
            <begin position="3405"/>
            <end position="3575"/>
        </location>
    </feature>
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        <location>
            <begin position="5292"/>
            <end position="5445"/>
        </location>
    </feature>
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        <location>
            <begin position="5460"/>
            <end position="5621"/>
        </location>
    </feature>
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        <location>
            <begin position="9682"/>
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        </location>
    </feature>
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        <location>
            <begin position="9835"/>
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        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="1337"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1543"/>
        </location>
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    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="3286"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="3465"/>
        </location>
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    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="9718"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="9913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="13413" mass="1516301" checksum="503E337510902525" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR22</accession>
    <name>Q5CR22_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extracellular membrane associated protein with a signal peptide, 5 ankyrin repeats, SUSHI domain and a transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_2420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_625830.1"/>
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    <dbReference type="InParanoid" id="Q5CR22"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Ankyrin_rpt"/>
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        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
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        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
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        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134:SF9">
        <property type="entry name" value="ANKYRIN REPEAT AND SOCS BOX PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24134">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN DDB_G0279043"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50923">
        <property type="entry name" value="SUSHI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0812">Transmembrane</keyword>
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        <location>
            <begin position="559"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="169"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="222"/>
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        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="258"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="294"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="334"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="477"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="599" mass="67359" checksum="AC63B1A0B40C6C39" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR66</accession>
    <name>Q5CR66_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Endonuclease/exonuclease/phosphatase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_1920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625786.1">
        <property type="nucleotide sequence ID" value="XM_625786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR66"/>
    <dbReference type="STRING" id="353152.Q5CR66"/>
    <dbReference type="GeneID" id="3372893"/>
    <dbReference type="KEGG" id="cpv:cgd4_1920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1920"/>
    <dbReference type="InParanoid" id="Q5CR66"/>
    <dbReference type="OMA" id="QYRWFRG"/>
    <dbReference type="OrthoDB" id="428734at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF34">
        <property type="entry name" value="PROTEIN ANGEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="362"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="782" mass="88143" checksum="E93DC1B7A05414BF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR79</accession>
    <name>Q5CR79_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625773.1">
        <property type="nucleotide sequence ID" value="XM_625773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR79"/>
    <dbReference type="GeneID" id="3372902"/>
    <dbReference type="KEGG" id="cpv:cgd4_1790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1790"/>
    <dbReference type="InParanoid" id="Q5CR79"/>
    <dbReference type="OMA" id="RYSHDRM"/>
    <dbReference type="OrthoDB" id="340231at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="235" mass="26081" checksum="75FCEE2C4A910328" modified="2005-04-12" version="1">MDNASKESDTEVIEKKMSCEIFSTRFRAFLSYFLPMVYGISLFSVAWLKVSSPIFIAVCLAFGSIDVITSIVGMIGILCPSGLAIRSTIPLLAMENLVTFLISIGLFVESIMYKNTKDFVILDFSVGLTLSFVLMISTILSVICIWKISEYLNEIEASSIFEELSGKKFRSSKYMNSINKISSNLDNKPLLSRINSRDIKDKEVKAGDATTTTTTNVNTKNNIDSDNNLAIVIKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRE7</accession>
    <name>Q5CRE7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626239.1">
        <property type="nucleotide sequence ID" value="XM_626239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRE7"/>
    <dbReference type="GeneID" id="3373250"/>
    <dbReference type="KEGG" id="cpv:cgd5_3080"/>
    <dbReference type="InParanoid" id="Q5CRE7"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254153" evidence="1">
        <location>
            <begin position="20"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="168" mass="19483" checksum="A3C3307F9267FA28" modified="2005-04-12" version="1">MKLIIVLLFLVSFKDFIHLHINIISLFKEIFQAPKFSLRNTPKGVVCQNDDVACKTYVYDCSDTRLVCHMEDMIWLFQTFPNKLNDNVDRVFINEQNLALTFFSQLIKKSLGETETLSKKQQQIFRKSSFPESLDISPDVNSWDSFSDGGKSKLSFFPPKRKNLTICN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRF7</accession>
    <name>Q5CRF7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Forkhead associated domain (FHA) containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626229.1">
        <property type="nucleotide sequence ID" value="XM_626229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRF7"/>
    <dbReference type="GeneID" id="3373244"/>
    <dbReference type="KEGG" id="cpv:cgd5_2940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2940"/>
    <dbReference type="InParanoid" id="Q5CRF7"/>
    <dbReference type="OrthoDB" id="687730at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="2">
        <location>
            <begin position="147"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="263" mass="30387" checksum="BE12D66A5EEE2D64" modified="2005-04-12" version="1">MRRYSSEEDDEFYSDSIECSEFEDSIEMVRSQNVGNKEFEEEDGIEVEDEEENNSDNNNEYGILNSHKRFRKIESSQESYTQNSNFNYLNNEIKDINSKIELINSNIENIITNSGNLSNPVCILEQIPTDNKNSGKKVLIQVGNSGLKIGRNSDCDFPGKMVPNKNLLRLSRNHAYLYVKKNNKGKDQIYLVDCNSANGTYVNNIRIKNKILKSNDILSFGEKDDDNDNSQRFEQKLSLNQQRRKNILTSENYCKFKVILCNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRG0</accession>
    <name>Q5CRG0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626226.1">
        <property type="nucleotide sequence ID" value="XM_626226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRG0"/>
    <dbReference type="STRING" id="353152.Q5CRG0"/>
    <dbReference type="GeneID" id="3373242"/>
    <dbReference type="KEGG" id="cpv:cgd5_2900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2900"/>
    <dbReference type="InParanoid" id="Q5CRG0"/>
    <dbReference type="OMA" id="FARMPDT"/>
    <dbReference type="OrthoDB" id="10266364at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="46"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="428" mass="47724" checksum="E216EAB257462A49" modified="2005-04-12" version="1">MWNIASEFICGCFQQGSFAKKMLEDTAKELDITRADELSFFGAAISSQHELKQQKSSINADSWLVSWNLLGIADGVSSVESEGFDPSQLPSELLKNCVELCNIRENNRVQFDSASQKIFNKNSIPFHSYEFLKHILCRSCSNCASYGSTTCLLCFLDGNQLWVSNVGDSQMIVLRPSKNEPKNLPPIPFIENPIERKPITGDPRRRLPSNISVGGYDITARSEVQQHFFNCPHQLTIMPDINCSNDEILKRAANVSQSFRVDVNPGDLIIIGTDGIFDNIFDEDIIDIVNQARKRYNRVFDDNPIMVSDFIAKELLTYALKAANNVPSGSRARVTPFSEGALIDVNRHIEGGKPDDITVIVAFVAYSDRLSTRMSNISPEIYSGTSYLGSSAKFSNDMSTYIINGEKYSYSSISERFSILGGLTSKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRP2</accession>
    <name>Q5CRP2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626144.1">
        <property type="nucleotide sequence ID" value="XM_626144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRP2"/>
    <dbReference type="STRING" id="353152.Q5CRP2"/>
    <dbReference type="GeneID" id="3373264"/>
    <dbReference type="KEGG" id="cpv:cgd5_2030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2030"/>
    <dbReference type="InParanoid" id="Q5CRP2"/>
    <dbReference type="OMA" id="FREPVCI"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="25"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="201" mass="22925" checksum="5AF37B67B2076E75" modified="2005-04-12" version="1">MNINNEASNTRAMQLHTLNKLASEKRNGNEAVEISLESNVNLNESFMLNCKGELGKAISILEESREIIYSDVDEQMIIKISFIEPVSITKFGIQALDIENESEEFGIHDKTELDLKNCSKPRLAKLYVNSPLVDFGEIEDLTPSFTKVFTEQELQESLVFTLPGSKFHRLKHLTIFIEENQDLKEKTYLNKIKLLGYIIPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRS4</accession>
    <name>Q5CRS4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein with an N-terminal domain shared with the TOG/ALp4p ike microtubule associated proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_1680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626112.1">
        <property type="nucleotide sequence ID" value="XM_626112.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRS4"/>
    <dbReference type="GeneID" id="3373014"/>
    <dbReference type="KEGG" id="cpv:cgd5_1680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1680"/>
    <dbReference type="InParanoid" id="Q5CRS4"/>
    <dbReference type="OMA" id="ENGHELF"/>
    <dbReference type="OrthoDB" id="205662at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061863">
        <property type="term" value="F:microtubule plus end polymerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051010">
        <property type="term" value="F:microtubule plus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030951">
        <property type="term" value="P:establishment or maintenance of microtubule cytoskeleton polarity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007051">
        <property type="term" value="P:spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034085">
        <property type="entry name" value="TOG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045110">
        <property type="entry name" value="XMAP215"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048491">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12609">
        <property type="entry name" value="MICROTUBULE ASSOCIATED PROTEIN XMAP215"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21041">
        <property type="entry name" value="XMAP215_CLASP_TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01349">
        <property type="entry name" value="TOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TOG" evidence="5">
        <location>
            <begin position="305"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="595"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="603"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1359" mass="156563" checksum="DC7F71547BFE7022" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRY3</accession>
    <name>Q5CRY3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Apicomplexan conserved protein with 9 transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_1020</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626053.1">
        <property type="nucleotide sequence ID" value="XM_626053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRY3"/>
    <dbReference type="FunCoup" id="Q5CRY3">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="GeneID" id="3373125"/>
    <dbReference type="KEGG" id="cpv:cgd5_1020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1020"/>
    <dbReference type="InParanoid" id="Q5CRY3"/>
    <dbReference type="OMA" id="YYGPLAC"/>
    <dbReference type="OrthoDB" id="165382at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF9">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA8-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="101"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="169"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="506" mass="56661" checksum="D53F357FACF3E738" modified="2005-04-12" version="1">MSLFKDENMEESYFFMLITNFPVLSLTIGIVLTIVGSCFMAFGNAYMKKGLHIQQQKCINDSQTNVYSMAYNEVTWWIGVISYAFGAIIHIIALGFAPASILAPMNSFGLVANAFAAATLLDEQFGIFELISTVGVIFGICLCAIASVIPTEAPTTKYSGIESWSDPYYLIYIIFCFICALAVLIVINNEEAKYNEQKEIQTRRAILKSLDEDSLGIIPTGKVSPNNSLNLNNHAKIKINLPKYPKYISMLYGFLAGLIGAQCVLEIKEMVAWGEFALQHTKDWMYNIQPYLAFIFFSTSTWLQMHFLNLGLAMGDATLVVPAYYVFWTLFSTFGGFTKFHEFEGFTFIMTIIFSFGIIITTSFVIVMSIREILAFKKAVDESVTDNDGITEEVPKLDGMKGNMLDTQLPLAMGVLTMINAGKLAGKYFMNTSGQLRKTRSASDLIGEKRGSIEITTRQKDIWTLPSNVNYSNANDPNSSTYQNSVWRPKPINELVFEDVEYKEIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS44</accession>
    <name>Q5CS44_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625992.1">
        <property type="nucleotide sequence ID" value="XM_625992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS44"/>
    <dbReference type="GeneID" id="3373190"/>
    <dbReference type="KEGG" id="cpv:cgd5_300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_300"/>
    <dbReference type="InParanoid" id="Q5CS44"/>
    <dbReference type="OMA" id="YECWADI"/>
    <dbReference type="OrthoDB" id="338711at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="479" mass="56347" checksum="37EAB78A292EEBDB" modified="2005-04-12" version="1">MAFQQLNKDLIGLISSFLPYDEIIINLRNVNKQWKDSINSSYDCWLNIDLTETMTEFQCSKEDISLEEIKMYSNIISSIRLSNPINNISGFLSKMILINDKSNNYERCKMWNKLENIEIYNKSLIIPIKNNKNYHLLPFKSLFRLGINENILQLLKYYEISNKKSMDESENNCDIKYFMNSFTDIINYYPFKSVKRIIIDYPISTKELNILSNCFPCLKDIVITRLFHETNTYNSHYEEFTQENRRLSFGSEIGSGDDISSRYGNLSIDDENEFHFENEIIACWEAIYNFLQVIPPNQLRILQFNVIPSPNPKSGKWTTDSTISRIVSENTKNGCNYINHNNNYKNDNICNNQNILYSVNDDKNEKQILESVEIYKAIKRSNREYIDYKNKIMRTNEYYNNNSNNDNSSIFNHSSSMINFDEVGDKLMKYILDMHSESLVALSCPDLEVSYALYKRLLNQCPKLKLWDLPGWRIFSCIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS46</accession>
    <name>Q5CS46_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide containing protein with 6 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Iowa type II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625990.1">
        <property type="nucleotide sequence ID" value="XM_625990.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS46"/>
    <dbReference type="STRING" id="353152.Q5CS46"/>
    <dbReference type="GeneID" id="3373192"/>
    <dbReference type="KEGG" id="cpv:cgd5_280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_280"/>
    <dbReference type="InParanoid" id="Q5CS46"/>
    <dbReference type="OrthoDB" id="344181at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="94"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="148"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="184"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="281"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="320" mass="36439" checksum="5765BA139A73C17C" modified="2005-04-12" version="1">MNPYQHIKISILNCIKLISNLETISIIFGYLFTISTGQPCGTFITRFSIYYIPDITKEKSIRMIQILTVIELFVRVISGYLSDLLANNKIMYKSTQTIILTLTMSLSLLLINYLKSYWLVVIFGVGFSYAGMYSIAPSYIRSLFKPTEFALVNSFCYSMVIPGNLILSLVLANTPQKYTTSLQIIGYLSLIPLSIMIVYKIQYLYKKCIIKNEMQDETIEDDENNDNNNKNIFENIEYGIDKIAQDITILQKDINNFQKVMSEINLIDKIKNKDKSDKNNKNNNNNNNNSLTISTYSSSSSMLPSSGDISKNTSMSNIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS95</accession>
    <name>Q5CS95_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_3600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628172.1">
        <property type="nucleotide sequence ID" value="XM_628172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS95"/>
    <dbReference type="GeneID" id="3371518"/>
    <dbReference type="KEGG" id="cpv:cgd1_3600"/>
    <dbReference type="InParanoid" id="Q5CS95"/>
    <dbReference type="OrthoDB" id="341968at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="402" mass="47676" checksum="C9323517B88420ED" modified="2005-04-12" version="1">MRYYRENSFSMLKVLELRNLYIPLDTFDHLILMFSLSNNNSRYKFQGYEIEGNQLLYNYQKVYATYNLKFEDGSSKNHHYNINKYHSMSIQEESDFMLNSDYTNLGFSHPDDISCKNKNDYDLLGMKLKDKDNYNKNTKESSKINENGYMNNKLQNKSPFQHDSQVMQPFLDIKRWIINISKTKENNNQENISNVLYSLNTHILILDNQLQEMKYQSITEIHRNLISRTILEYLVDPIKTCLSISNSRIVLSFGFDNLIYSGYMLGVLFEYQVTLKELSALSFLIPIDFFCQLKLNRIQVLKVSLFKDKNLEPKDLIQLCSWIERYGKNLNYIHIRVTGSSSKWVPKETEITRLINLWKKMCPKTLEGKSQEKIKFECCFTDHIFSKMEKLPKDFEYDTESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSG2</accession>
    <name>Q5CSG2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Contains a UVDDB domain that is present in CPSF_A and damage specific DNA binding protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_2840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628105.1">
        <property type="nucleotide sequence ID" value="XM_628105.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSG2"/>
    <dbReference type="GeneID" id="3371347"/>
    <dbReference type="KEGG" id="cpv:cgd1_2840"/>
    <dbReference type="InParanoid" id="Q5CSG2"/>
    <dbReference type="OMA" id="MSQYNYV"/>
    <dbReference type="OrthoDB" id="6109at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="5">
        <location>
            <begin position="21"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="4">
        <location>
            <begin position="1188"/>
            <end position="1358"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="669"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1495" mass="171390" checksum="CAFE85B23B6C5DFC" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSI5</accession>
    <name>Q5CSI5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Tom40p like translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_2560</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion outer membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tom40 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628082.1">
        <property type="nucleotide sequence ID" value="XM_628082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSI5"/>
    <dbReference type="FunCoup" id="Q5CSI5">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSI5"/>
    <dbReference type="GeneID" id="3371694"/>
    <dbReference type="KEGG" id="cpv:cgd1_2560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2560"/>
    <dbReference type="InParanoid" id="Q5CSI5"/>
    <dbReference type="OMA" id="TRFNYRW"/>
    <dbReference type="OrthoDB" id="19656at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005741">
        <property type="term" value="C:mitochondrial outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07305">
        <property type="entry name" value="Porin3_Tom40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027246">
        <property type="entry name" value="Porin_Euk/Tom40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037930">
        <property type="entry name" value="Tom40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10802">
        <property type="entry name" value="MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01459">
        <property type="entry name" value="Porin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-1000">Mitochondrion outer membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1134">Transmembrane beta strand</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="309" mass="34916" checksum="C1B2A8126EEF8822" modified="2005-04-12" version="1">MSRLQHETDGGNERTNKSLQYENFSLESQSIFQRESFDGFRAEIAKSVTSNLQTSYSLFLGTSNIKGYSYQLGPSYQSSSKNTLILARVNDEGTVSGRFSRCFGNNIEGRISINSSLSDENKNMSEVSIDYNGEESSYSLKVAYQGIFLLNGLFSQLITNKLQLGGELTWIAANNTSIMSLGSRYCHGKNIFFNQITRQPDFTSPGRIFANIHSLRSSFYRKLSDRLSLASELEVSIPNFESTLRFGYEYLFKTARIQGMIDTCGKISLQCLDNKGFGISAAIDYLRNDYKFGFMMQFFPNEKDDKLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSL6</accession>
    <name>Q5CSL6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain containing protein with a cysteine cluster at the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628051.1">
        <property type="nucleotide sequence ID" value="XM_628051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSL6"/>
    <dbReference type="STRING" id="353152.Q5CSL6"/>
    <dbReference type="GeneID" id="3371679"/>
    <dbReference type="KEGG" id="cpv:cgd1_2170"/>
    <dbReference type="InParanoid" id="Q5CSL6"/>
    <dbReference type="OMA" id="EYINIVM"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="30"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="385" mass="43855" checksum="AD6F53E1CC8FBDF1" modified="2005-04-12" version="1">MDSCIEGKCEIENNYHILLDEINSLTGNENYFDIFYSENKGKHIHSSKEIPDGTNFFQEVPYISWPIKTSFAKLENLIFCENCLKINYPENSGFLSLSTLGLEKKICSRSCFKKISGVNFEDYDPNSSSLRSGWGYYINGTKGILNLRNYQRSVDKLGDIPITAEAVSRCIAQMAADIYFYWQELGMKDENLYHAYKLGTKSMENFVAPTTALFPEINFNSLINCIHSVLSDQINDSFSDSFIIDSLLSRETIEQIVGQLTLNSQGLNIWGLHLSGKLDNRNISDNEPTIGIIKGACICVIQSCFNHSCDPNCHVYTIDDSTIYVTTNRDIMKGEELTISYVDNTLPLAERTSLIQNYHFTCTCRLCKKEERSNHTDSRKKKRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSM7</accession>
    <name>Q5CSM7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Pyruvate kinase</fullName>
            <ecNumber evidence="4 13">2.7.1.40</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd1_2040</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2010-03" db="PDB data bank">
            <title>Crystal structure of CGD1_2040, a pyruvate kinase from cryptosporidium Parvum.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Hutchinson A."/>
                <person name="Hassanali A."/>
                <person name="Kozieradzki I."/>
                <person name="Cossar D."/>
                <person name="Bochkarev A."/>
                <person name="Arrowsmith C.H."/>
                <person name="Edwards A.M."/>
                <person name="Bountra C."/>
                <person name="Weigelt J."/>
                <person name="Hui R."/>
                <person name="Hills T."/>
                <person name="Pizarro J.C."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.64 ANGSTROMS) OF 17-532</scope>
    </reference>
    <reference evidence="19" key="3">
        <citation type="journal article" date="2012" name="PLoS ONE" volume="7" first="e46875" last="e46875">
            <title>Crystal structure of Cryptosporidium parvum pyruvate kinase.</title>
            <authorList>
                <person name="Cook W.J."/>
                <person name="Senkovich O."/>
                <person name="Aleem K."/>
                <person name="Chattopadhyay D."/>
            </authorList>
            <dbReference type="PubMed" id="23056503"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0046875"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 7-532</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <reference evidence="20" key="4">
        <citation type="journal article" date="2019" name="Protein Sci." volume="28" first="1771" last="1784">
            <title>An overview of structure, function, and regulation of pyruvate kinases.</title>
            <authorList>
                <person name="Schormann N."/>
                <person name="Hayden K.L."/>
                <person name="Lee P."/>
                <person name="Banerjee S."/>
                <person name="Chattopadhyay D."/>
            </authorList>
            <dbReference type="PubMed" id="31342570"/>
            <dbReference type="DOI" id="10.1002/pro.3691"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 7-532 IN COMPLEX WITH ADP</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>pyruvate + ATP = phosphoenolpyruvate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:18157"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58702"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.40"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 5/5.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the pyruvate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.40" evidence="4 13"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628040.1">
        <property type="nucleotide sequence ID" value="XM_628040.1"/>
    </dbReference>
    <dbReference type="PDB" id="3MA8">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.64 A"/>
        <property type="chains" value="A/B=17-532"/>
    </dbReference>
    <dbReference type="PDB" id="4DRS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.50 A"/>
        <property type="chains" value="A/B=7-532"/>
    </dbReference>
    <dbReference type="PDB" id="6P0Y">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.60 A"/>
        <property type="chains" value="A/B=7-532"/>
    </dbReference>
    <dbReference type="PDBsum" id="3MA8"/>
    <dbReference type="PDBsum" id="4DRS"/>
    <dbReference type="PDBsum" id="6P0Y"/>
    <dbReference type="AlphaFoldDB" id="Q5CSM7"/>
    <dbReference type="SMR" id="Q5CSM7"/>
    <dbReference type="FunCoup" id="Q5CSM7">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSM7"/>
    <dbReference type="GeneID" id="3371357"/>
    <dbReference type="KEGG" id="cpv:cgd1_2040"/>
    <dbReference type="InParanoid" id="Q5CSM7"/>
    <dbReference type="OMA" id="RVHHIGE"/>
    <dbReference type="OrthoDB" id="108365at2759"/>
    <dbReference type="BRENDA" id="2.7.1.40">
        <property type="organism ID" value="1728"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00188"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="Q5CSM7"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030955">
        <property type="term" value="F:potassium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004743">
        <property type="term" value="F:pyruvate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.33.10:FF:000001">
        <property type="entry name" value="Pyruvate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.60">
        <property type="entry name" value="Phosphoenolpyruvate-binding domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.33.10">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1380.20">
        <property type="entry name" value="Pyruvate kinase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001697">
        <property type="entry name" value="Pyr_Knase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040442">
        <property type="entry name" value="Pyrv_kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011037">
        <property type="entry name" value="Pyrv_Knase-like_insert_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018209">
        <property type="entry name" value="Pyrv_Knase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015793">
        <property type="entry name" value="Pyrv_Knase_brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015795">
        <property type="entry name" value="Pyrv_Knase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036918">
        <property type="entry name" value="Pyrv_Knase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015806">
        <property type="entry name" value="Pyrv_Knase_insert_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004491">
        <property type="entry name" value="PRK05826.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004978">
        <property type="entry name" value="PRK06354.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01064">
        <property type="entry name" value="pyruv_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11817">
        <property type="entry name" value="PYRUVATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00224">
        <property type="entry name" value="PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02887">
        <property type="entry name" value="PK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01050">
        <property type="entry name" value="PYRUVTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50800">
        <property type="entry name" value="PK beta-barrel domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52935">
        <property type="entry name" value="PK C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00110">
        <property type="entry name" value="PYRUVATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="18 19 20" id="KW-0002">3D-structure</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8 13 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 20" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12 16" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 13 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Pyruvate kinase barrel" evidence="14">
        <location>
            <begin position="50"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="domain" description="Pyruvate kinase C-terminal" evidence="15">
        <location>
            <begin position="416"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="82"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="122"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Interchain (with C-318)" evidence="19 20">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Interchain (with C-32)" evidence="19 20">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="20">
        <location>
            <begin position="519"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK88569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="3MA8"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="4DRS"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="6P0Y"/>
        </source>
    </evidence>
    <sequence length="532" mass="57172" checksum="F2950B843B61A41A" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSW8</accession>
    <name>Q5CSW8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627949.1">
        <property type="nucleotide sequence ID" value="XM_627949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSW8"/>
    <dbReference type="GeneID" id="3371553"/>
    <dbReference type="KEGG" id="cpv:cgd1_1040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1040"/>
    <dbReference type="InParanoid" id="Q5CSW8"/>
    <dbReference type="OMA" id="ACMTILR"/>
    <dbReference type="OrthoDB" id="371976at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="587" mass="69531" checksum="C8CEEE17981CE74E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSY9</accession>
    <name>Q5CSY9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Leucine rich repeats, coiled coil</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627928.1">
        <property type="nucleotide sequence ID" value="XM_627928.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3371532"/>
    <dbReference type="KEGG" id="cpv:cgd1_790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_790"/>
    <dbReference type="InParanoid" id="Q5CSY9"/>
    <dbReference type="OMA" id="RINGRCI"/>
    <dbReference type="OrthoDB" id="341587at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="798"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1364"/>
            <end position="1385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1398" mass="159329" checksum="CE67914A5A2BD5F3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT44</accession>
    <name>Q5CT44_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted secreted protein, signal peptide, paralogs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627873.1">
        <property type="nucleotide sequence ID" value="XM_627873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT44"/>
    <dbReference type="GeneID" id="3371438"/>
    <dbReference type="KEGG" id="cpv:cgd1_110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_110"/>
    <dbReference type="InParanoid" id="Q5CT44"/>
    <dbReference type="OrthoDB" id="343461at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254495" evidence="2">
        <location>
            <begin position="23"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="251"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="406" mass="47087" checksum="E3CCB8444F0DD8AD" modified="2005-04-12" version="1">MKPTKPFLCLLILAVSFVSIYSAEAPYNFNFQENQESSFQLRKLYLLSDFAYLVKSLYLCLQKFEIKEIRKFGSDSSTLSFLSIDLNMFILENQQDKQLYISNFYSRMLKILNGKLKECHEKNSRFEWAFLESNLGKLEVIGKEVIKIVKFFDNFSFGKEISSTIEQTVNISTKLFYELLKIIKIESIKQNDQKIKEKELKEYNEREESSNLAAHILIGCCRDGKCNSLDPSKKKYKSSRKKNRGGRKKRTVAEGRNEHSQSDADQSNDRCELLNIKYEDQLVKESVGAVSKLIELLQEIANHEENLVKVSNLFELDVKKLKENFELFKPSKSLFTRFNVLVNEEGNHKHTFEGVKAPSSEYSLRLISKSSHFELNGIVANLETNHCHHSTHKCKEKIKKLINNPD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT92</accession>
    <name>Q5CT92_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative translation elongation factor 1 beta 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_3950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EF-1-beta/EF-1-delta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626577.1">
        <property type="nucleotide sequence ID" value="XM_626577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT92"/>
    <dbReference type="STRING" id="353152.Q5CT92"/>
    <dbReference type="GeneID" id="3373397"/>
    <dbReference type="KEGG" id="cpv:cgd2_3950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3950"/>
    <dbReference type="InParanoid" id="Q5CT92"/>
    <dbReference type="OMA" id="YRWYKHI"/>
    <dbReference type="OrthoDB" id="331763at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005853">
        <property type="term" value="C:eukaryotic translation elongation factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00292">
        <property type="entry name" value="EF1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036219">
        <property type="entry name" value="eEF-1beta-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049720">
        <property type="entry name" value="EF1B_bsu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014038">
        <property type="entry name" value="EF1B_bsu/dsu_GNE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014717">
        <property type="entry name" value="Transl_elong_EF1B/ribsomal_bS6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595">
        <property type="entry name" value="EF-HAND AND COILED-COIL DOMAIN-CONTAINING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11595:SF21">
        <property type="entry name" value="ELONGATION FACTOR 1-BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00736">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00888">
        <property type="entry name" value="EF1_GNE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54984">
        <property type="entry name" value="eEF-1beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation elongation factor EF1B beta/delta subunit guanine nucleotide exchange" evidence="5">
        <location>
            <begin position="133"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="213"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="222"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="247" mass="27618" checksum="F38FA8A0B53CA645" modified="2005-04-12" version="1">MDKFGDISTDAGRKKLNDYLSTRSYMNGVSPTQDDVEALYMIMKAGGFCDFQHICRYVSHIQSFSAMERDAFPGESFKNKLKNKGCTKEKKSNDDDFDLFGDDDEDMEAAKKAMEAKKKALQDKKAKEKPASKSSLVLDIKPSSLDVDLDAVAKMIRALKIEGVEFSEGEKKVPVAFGLFKLQMGATIIDDLVNTQDIVDSIETLGMTDEQKKKFSEKDDACGDDDEEEEEEYGLVQSCEIVSFNKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTA2</accession>
    <name>Q5CTA2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626567.1">
        <property type="nucleotide sequence ID" value="XM_626567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTA2"/>
    <dbReference type="GeneID" id="3373407"/>
    <dbReference type="KEGG" id="cpv:cgd2_3830"/>
    <dbReference type="InParanoid" id="Q5CTA2"/>
    <dbReference type="OMA" id="NTRFENR"/>
    <dbReference type="OrthoDB" id="341617at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="51"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="601" mass="68247" checksum="4FF6175BC92B68C6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTD1</accession>
    <name>Q5CTD1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cus1p U2 snRNP protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_3510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626538.1">
        <property type="nucleotide sequence ID" value="XM_626538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTD1"/>
    <dbReference type="STRING" id="353152.Q5CTD1"/>
    <dbReference type="GeneID" id="3373627"/>
    <dbReference type="KEGG" id="cpv:cgd2_3510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3510"/>
    <dbReference type="InParanoid" id="Q5CTD1"/>
    <dbReference type="OMA" id="KGEPIGQ"/>
    <dbReference type="OrthoDB" id="10260794at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007180">
        <property type="entry name" value="DUF382"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006568">
        <property type="entry name" value="PSP_pro-rich"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052584">
        <property type="entry name" value="U2_snRNP_Complex_Component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785">
        <property type="entry name" value="SPLICING FACTOR 3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12785:SF6">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04037">
        <property type="entry name" value="DUF382"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04046">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00581">
        <property type="entry name" value="PSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PSP proline-rich" evidence="3">
        <location>
            <begin position="362"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="10"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="181"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="40"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="602" mass="71066" checksum="7A1700CC0379C7B7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTF7</accession>
    <name>Q5CTF7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_3210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626512.1">
        <property type="nucleotide sequence ID" value="XM_626512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTF7"/>
    <dbReference type="GeneID" id="3373557"/>
    <dbReference type="KEGG" id="cpv:cgd2_3210"/>
    <dbReference type="InParanoid" id="Q5CTF7"/>
    <dbReference type="OMA" id="IAMAQNN"/>
    <dbReference type="OrthoDB" id="342030at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="297" mass="34815" checksum="97F4439BC96CC89F" modified="2005-04-12" version="1">MENILSGIEHDKSLNGNFEDQNRETLLSDFPSVEDYPNKKKSYEAEEDSFVKFDTRMMRHFSIEDITFNNTIRNFDNDKAKYHRIIKSGIKFAEYSLELSKRQKKNTLISTGIKKHKILKLNQERSIASASIIASVTIIKSLLYKEFPTNIRWTYYSFYPLILSSYLQAYNNLKTENKSKGFFSKAMYIRKSQALSRLNKSLLRITRHINNLEIDGKYNYSVKPKHFWKLIEPTVVSPAHGLITTDLIKKPKSLSGEYLKDVMSILKSNKYKLAIAQNKAREDFYYYINHDLEIIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTQ0</accession>
    <name>Q5CTQ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_2140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626419.1">
        <property type="nucleotide sequence ID" value="XM_626419.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373524"/>
    <dbReference type="KEGG" id="cpv:cgd2_2140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2140"/>
    <dbReference type="InParanoid" id="Q5CTQ0"/>
    <dbReference type="OMA" id="ESWINID"/>
    <dbReference type="OrthoDB" id="342199at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="334"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="402"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="513"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="660"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1075"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1227"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1335"/>
            <end position="1356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1407"/>
            <end position="1430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1436"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1486"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1765"/>
            <end position="1818"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1774"/>
            <end position="1784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1802"/>
            <end position="1818"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1818" mass="209320" checksum="733DC54940E84D65" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU49</accession>
    <name>Q5CU49_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Secreted insulinase like peptidase, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd3_4220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626965.1">
        <property type="nucleotide sequence ID" value="XM_626965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU49"/>
    <dbReference type="STRING" id="353152.Q5CU49"/>
    <dbReference type="GeneID" id="3373888"/>
    <dbReference type="KEGG" id="cpv:cgd3_4220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4220"/>
    <dbReference type="InParanoid" id="Q5CU49"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="7">
        <location>
            <begin position="129"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="8">
        <location>
            <begin position="307"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1275" mass="148336" checksum="8F4C289DA7D50C7D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUF1</accession>
    <name>Q5CUF1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 3</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd3_3080</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626863.1">
        <property type="nucleotide sequence ID" value="XM_626863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUF1"/>
    <dbReference type="STRING" id="353152.Q5CUF1"/>
    <dbReference type="GeneID" id="3374089"/>
    <dbReference type="KEGG" id="cpv:cgd3_3080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3080"/>
    <dbReference type="InParanoid" id="Q5CUF1"/>
    <dbReference type="OMA" id="PIYTHIS"/>
    <dbReference type="OrthoDB" id="338507at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048685">
        <property type="entry name" value="COG3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048320">
        <property type="entry name" value="COG3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007265">
        <property type="entry name" value="COG_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13302:SF8">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20671">
        <property type="entry name" value="COG3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04136">
        <property type="entry name" value="COG3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 N-terminal" evidence="10">
        <location>
            <begin position="104"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Conserved oligomeric Golgi complex subunit 3 C-terminal" evidence="11">
        <location>
            <begin position="274"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF20671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1001" mass="116415" checksum="A2CF4868750484A5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUL3</accession>
    <name>Q5CUL3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626801.1">
        <property type="nucleotide sequence ID" value="XM_626801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUL3"/>
    <dbReference type="GeneID" id="3373918"/>
    <dbReference type="KEGG" id="cpv:cgd3_2380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2380"/>
    <dbReference type="InParanoid" id="Q5CUL3"/>
    <dbReference type="OMA" id="NFLNICA"/>
    <dbReference type="OrthoDB" id="341472at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="121" mass="13607" checksum="70FF9D3B743B5F59" modified="2005-04-12" version="1">MSSSILVNRTSAFGRNELTEVDIFNICRSIKSCGECQLSKFCSPCKVSSSSEFFCTSKVDSITSCRQNTMSNICASAWPWWIYLCLVLLSLVILGMTLIILYKCCTCLFVKVQETELEDLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUQ5</accession>
    <name>Q5CUQ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein with 2x rrm domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_1880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626759.1">
        <property type="nucleotide sequence ID" value="XM_626759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUQ5"/>
    <dbReference type="STRING" id="353152.Q5CUQ5"/>
    <dbReference type="GeneID" id="3373829"/>
    <dbReference type="KEGG" id="cpv:cgd3_1880"/>
    <dbReference type="InParanoid" id="Q5CUQ5"/>
    <dbReference type="OMA" id="CTWDGRE"/>
    <dbReference type="OrthoDB" id="360390at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF119">
        <property type="entry name" value="NUCLEAR RNA-BINDING PROTEIN SART-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="984"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="624"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="801"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="942"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="965"/>
            <end position="974"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1142" mass="128936" checksum="EEF536B16C7A07E7" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUR7</accession>
    <name>Q5CUR7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Signal peptide containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_1750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626747.1">
        <property type="nucleotide sequence ID" value="XM_626747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUR7"/>
    <dbReference type="SMR" id="Q5CUR7"/>
    <dbReference type="STRING" id="353152.Q5CUR7"/>
    <dbReference type="GeneID" id="3374163"/>
    <dbReference type="KEGG" id="cpv:cgd3_1750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1750"/>
    <dbReference type="InParanoid" id="Q5CUR7"/>
    <dbReference type="OrthoDB" id="343831at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254252" description="Signal peptide containing protein" evidence="3">
        <location>
            <begin position="17"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="100"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="282" mass="32470" checksum="B8AD1685726D480F" modified="2005-04-12" version="1">MLFLWLLTIFFVFIGGINENKEILNHNIKLISFLHAEGGKDLRSSSSSPLTKETSTINSDDEELSLPSSWFIKKLESNAESYLESIGIGPDLTSKESCTESQLKKLLKELKKSLKKLILTNEQVKHYNENNSSGKYLTASFQEYLTEKKQEISMHKQNIESLLEQILKCLMLLRLDKYSRKIFKDNSVNCNAKTYTFTAVLKTTSKRVLSTLKKLLHKFDKEYKNSTKNITATFDHSTLSASVQTLNTLITKQKDITRKIKHKKKKCKMYMEFSSRDISTLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUR8</accession>
    <name>Q5CUR8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626746.1">
        <property type="nucleotide sequence ID" value="XM_626746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUR8"/>
    <dbReference type="GeneID" id="3374162"/>
    <dbReference type="KEGG" id="cpv:cgd3_1740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1740"/>
    <dbReference type="InParanoid" id="Q5CUR8"/>
    <dbReference type="OrthoDB" id="344166at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="327"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="380" mass="44289" checksum="0C2D7FCAA883C95E" modified="2005-04-12" version="1">MMHFLKIYIYSILYLIYLIQPKILVPQLIRNDHIFKLSFIKSEERQNFPIRMRIKESQDQAPGAPVESVEAQLKSNVADLSPSKPEHMPTSQFLAVFGLDEQMFVKGTCSLEVKDVFIKKIKKIVTFYFLYRGEYKRDYGTSGNKVKDMTVNTRNQSEFAKLMMRSGEVIMFMARYMSLLMNCIMYLLSHYYRKVSILYNEEGCTTYNIFFYLVMMEMIECILMVLKYSKRQLIKLIAKLAEGSYTDSESRIKAIDFALAMISETSDIEKEKFNRYKDKFESCKEYIKHTSSAKSSKHKGSKFDTSISEGSSSLKYSLKKLLGKKSKSNEKEEKKKDDGDEDGDEDGDEDEDEDEDEDPFWKLALDSLNMDAMYDDDVFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUS5</accession>
    <name>Q5CUS5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626739.1">
        <property type="nucleotide sequence ID" value="XM_626739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUS5"/>
    <dbReference type="GeneID" id="3374017"/>
    <dbReference type="KEGG" id="cpv:cgd3_1660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1660"/>
    <dbReference type="InParanoid" id="Q5CUS5"/>
    <dbReference type="OrthoDB" id="340919at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="276" mass="32412" checksum="849C8271ADEDA587" modified="2005-04-12" version="1">MKYIYVISSLISYIIVINAFALRKKEGLDLGLKKNLIQSRNSYNFECDVAIECMNILRCYYFFVAIVYEIISTSNCVSRSSDIEFRIHLSKNLSELNYYRNYFAEHIMDKGRSASLFEVIHEFPKRKASFLNVCSQIKFIDAKELYLIEQRVISNYLKVLMELKTYISADISNFFGSPFLINQGREVIKIINMAIDIILITQHKIQELERSSNKPTSIYKLSKVPQKLLVTKIYKRNLIVRISHIVKLRKYIRADKSDLLTILEDLERNNEMPPKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUV3</accession>
    <name>Q5CUV3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_1360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626711.1">
        <property type="nucleotide sequence ID" value="XM_626711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUV3"/>
    <dbReference type="STRING" id="353152.Q5CUV3"/>
    <dbReference type="GeneID" id="3373835"/>
    <dbReference type="KEGG" id="cpv:cgd3_1360"/>
    <dbReference type="InParanoid" id="Q5CUV3"/>
    <dbReference type="OMA" id="HWAVMDA"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF79">
        <property type="entry name" value="METHYLTRANSFERASE TYPE 11 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="5">
        <location>
            <begin position="52"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="255"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="257"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="268"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="284"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="293" mass="34305" checksum="BE4388D59635E68B" modified="2005-04-12" version="1" fragment="single">ILDLAIMADYGTTEYWEERYKKDSNPYDWYQRWENMREIIKEYLKFDDKILVVGNGTSRLPEEIYDDGYQSIEAMDISTVAVEIMHERFASRNIPCQVGNVLDMYQYSDDGYDVVIDKGTFDSILCGENSHINIDTMMRELVRVLNYDKGRYICISYGQPNYRLNYLKSMKEWEVTTIPIKKPANDQIYKLKNYNDEDSNSQENVNITTSTRPDLYHYIYVCTVVNKNVPEIGNSLNLNDDENGDIKTDNDVELNADNIQDPNNFEQDLGENQEDERNEFQVPDENKVLENSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV08</accession>
    <name>Q5CV08_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved expressed protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626656.1">
        <property type="nucleotide sequence ID" value="XM_626656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV08"/>
    <dbReference type="FunCoup" id="Q5CV08">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV08"/>
    <dbReference type="ESTHER" id="crypv-q5cv08">
        <property type="family name" value="ABHD13-BEM46"/>
    </dbReference>
    <dbReference type="GeneID" id="3374137"/>
    <dbReference type="KEGG" id="cpv:cgd3_730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_730"/>
    <dbReference type="InParanoid" id="Q5CV08"/>
    <dbReference type="OMA" id="WLPEQGY"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="164"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="419" mass="48098" checksum="B25290F891C80A40" modified="2005-04-12" version="1">MDLKLEFLNKTENRTTGCSVQCIFGKIILLIVSIILLLGLLVWIFQEKLLFFPNINGKRDLASNFPGYRHPNENKMNSEDVVLTTDDNVKLYCWFIIHKKFDRYSHGQSSAMHFSSNLTEPHHSEQVKKDGPEKKILDRIRKAPKYMKFHFPEFSDRYEQQEKAPTIVFFHGNAGNIGHRLPRFLEFYNLIGVNIFAVSYRGYGDSEGTPSEEGFYLDAKASLEYVLSRTDVVDKNMIFLYGHSIGGAVAIDLASKYNVTGVILENTFTNIKSVAFRVYPIFKYFGFFFKFIQRLKFDSVSKISRVKSPILFVVGNEDEIIPPTHSVELYMKAGSPKSLKKIYLVSGGSHNDTWIKGGMEFYLMLLQFIYNAIDYSKPELEVSSNNLINKSQEETLSSIQEILKTKESSPINKLRKKTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV19</accession>
    <name>Q5CV19_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626645.1">
        <property type="nucleotide sequence ID" value="XM_626645.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CV19"/>
    <dbReference type="GeneID" id="3373790"/>
    <dbReference type="KEGG" id="cpv:cgd3_600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_600"/>
    <dbReference type="InParanoid" id="Q5CV19"/>
    <dbReference type="OMA" id="WINDNNT"/>
    <dbReference type="OrthoDB" id="337023at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.100.10.30">
        <property type="entry name" value="Jacalin-like lectin domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036404">
        <property type="entry name" value="Jacalin-like_lectin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254537" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="491"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1429" mass="160634" checksum="33C86099957692B8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV42</accession>
    <name>Q5CV42_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626622.1">
        <property type="nucleotide sequence ID" value="XM_626622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV42"/>
    <dbReference type="STRING" id="353152.Q5CV42"/>
    <dbReference type="GeneID" id="3373803"/>
    <dbReference type="KEGG" id="cpv:cgd3_370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_370"/>
    <dbReference type="InParanoid" id="Q5CV42"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="104" mass="12345" checksum="B4A754AA47C8AB0D" modified="2005-04-12" version="1">MKFISVIFHYLLNNPKKKMKKKFEVYIYIYIYIYIQTNKGFQSFSINSLTPLTVCKNGKSIKFQCCLFRITQNSLGIMKTISRTYYSVKTLILFMVLKPKKESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV60</accession>
    <name>Q5CV60_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_5310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627409.1">
        <property type="nucleotide sequence ID" value="XM_627409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV60"/>
    <dbReference type="STRING" id="353152.Q5CV60"/>
    <dbReference type="GeneID" id="3374212"/>
    <dbReference type="KEGG" id="cpv:cgd8_5310"/>
    <dbReference type="InParanoid" id="Q5CV60"/>
    <dbReference type="OMA" id="TRWEEQE"/>
    <dbReference type="OrthoDB" id="343523at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254267" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="150"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="357"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="616"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="816"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="851"/>
            <end position="867"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1041" mass="118239" checksum="E060F4E3BB5BF770" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVC8</accession>
    <name>Q5CVC8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627341.1">
        <property type="nucleotide sequence ID" value="XM_627341.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3374440"/>
    <dbReference type="KEGG" id="cpv:cgd8_4560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4560"/>
    <dbReference type="InParanoid" id="Q5CVC8"/>
    <dbReference type="OMA" id="PYFVINS"/>
    <dbReference type="OrthoDB" id="341622at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019164">
        <property type="entry name" value="TMEM147"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09767">
        <property type="entry name" value="DUF2053"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="161" mass="17994" checksum="624FB2234F28F592" modified="2005-04-12" version="1">MGFPVFSGITLMILLMGPYYLMYNISSVFETTGTNPLLFTSISYSVSGCFLKSLLLASIPIPSQSTMEYLSIITKVIYLFFIRLILQSKNAKNHEVHVRINVGILGWCIAHTALTYFIPLATDTSLSSDFSLDYVRLILSSYSASLSTYTCFXLYVHVNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVH8</accession>
    <name>Q5CVH8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Large protein with 3x cNMP binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_4000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627291.1">
        <property type="nucleotide sequence ID" value="XM_627291.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVH8"/>
    <dbReference type="GeneID" id="3374593"/>
    <dbReference type="KEGG" id="cpv:cgd8_4000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4000"/>
    <dbReference type="InParanoid" id="Q5CVH8"/>
    <dbReference type="OMA" id="WIDIDAF"/>
    <dbReference type="OrthoDB" id="2021138at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45532">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45532:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="1102"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="1227"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="1729"/>
            <end position="1839"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="3">
        <location>
            <begin position="1901"/>
            <end position="1987"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="337"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="599"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1385"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="266"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="634"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="653"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="679"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="744"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="761"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="785"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="842"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1390"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1400"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1413"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1424"/>
            <end position="1436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2010" mass="231242" checksum="6838C66FBEE813D7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVN9</accession>
    <name>Q5CVN9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oocyst wall protein 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627230.1">
        <property type="nucleotide sequence ID" value="XM_627230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVN9"/>
    <dbReference type="STRING" id="353152.Q5CVN9"/>
    <dbReference type="GeneID" id="3374296"/>
    <dbReference type="KEGG" id="cpv:cgd8_3350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3350"/>
    <dbReference type="InParanoid" id="Q5CVN9"/>
    <dbReference type="OMA" id="HENTIQP"/>
    <dbReference type="OrthoDB" id="7250310at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254466" evidence="2">
        <location>
            <begin position="23"/>
            <end position="887"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="307"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="336"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="887" mass="100005" checksum="187821309EA40DDE" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVQ6</accession>
    <name>Q5CVQ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_3160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627213.1">
        <property type="nucleotide sequence ID" value="XM_627213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVQ6"/>
    <dbReference type="GeneID" id="3374240"/>
    <dbReference type="KEGG" id="cpv:cgd8_3160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3160"/>
    <dbReference type="InParanoid" id="Q5CVQ6"/>
    <dbReference type="OrthoDB" id="6222486at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09271">
        <property type="entry name" value="RNase_H2-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.680">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013924">
        <property type="entry name" value="RNase_H2_suC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08615">
        <property type="entry name" value="RNase_H2_suC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="122" mass="14296" checksum="A4BEAFA411BB2479" modified="2005-04-12" version="1">MSFNILPFQILFDGRLPKENPFNRLYNSTQSQLSVSNKVTNIVLSKSFRGRKLNGRIIHLSKSSHSILILSKNNSQKKMDLIIDKSFNQVTYWNYDDEIKQSDDIPQFLNVIHNFNILHRET</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVW9</accession>
    <name>Q5CVW9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_2490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627150.1">
        <property type="nucleotide sequence ID" value="XM_627150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVW9"/>
    <dbReference type="GeneID" id="3374275"/>
    <dbReference type="KEGG" id="cpv:cgd8_2490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2490"/>
    <dbReference type="InParanoid" id="Q5CVW9"/>
    <dbReference type="OMA" id="RICPAVE"/>
    <dbReference type="OrthoDB" id="341772at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253911" evidence="2">
        <location>
            <begin position="22"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="456"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="204"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="525"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="549" mass="62456" checksum="C5F703925BF13EF2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW36</accession>
    <name>Q5CW36_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">HxYxP motif containing repeats seen only in C. elegans F29G6.3b, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627083.1">
        <property type="nucleotide sequence ID" value="XM_627083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW36"/>
    <dbReference type="STRING" id="353152.Q5CW36"/>
    <dbReference type="GeneID" id="3374606"/>
    <dbReference type="KEGG" id="cpv:cgd8_1770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1770"/>
    <dbReference type="InParanoid" id="Q5CW36"/>
    <dbReference type="OMA" id="HEVNYHI"/>
    <dbReference type="OrthoDB" id="339031at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253915" evidence="1">
        <location>
            <begin position="24"/>
            <end position="1123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1123" mass="125382" checksum="786D9610EB8CBB97" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW71</accession>
    <name>Q5CW71_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA primase large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_1410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic-type primase large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627048.1">
        <property type="nucleotide sequence ID" value="XM_627048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW71"/>
    <dbReference type="FunCoup" id="Q5CW71">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW71"/>
    <dbReference type="GeneID" id="3374400"/>
    <dbReference type="KEGG" id="cpv:cgd8_1410"/>
    <dbReference type="InParanoid" id="Q5CW71"/>
    <dbReference type="OMA" id="RINYKPW"/>
    <dbReference type="OrthoDB" id="421393at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006269">
        <property type="term" value="P:DNA replication, synthesis of primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07322">
        <property type="entry name" value="PriL_PriS_Eukaryotic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058560">
        <property type="entry name" value="DNA_primase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016558">
        <property type="entry name" value="DNA_primase_lsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007238">
        <property type="entry name" value="DNA_primase_lsu_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10537:SF3">
        <property type="entry name" value="DNA PRIMASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04104">
        <property type="entry name" value="DNA_primase_lrg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26466">
        <property type="entry name" value="DNA_primase_lrg_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="9" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0639">Primosome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA primase large subunit C-terminal" evidence="10">
        <location>
            <begin position="353"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF04104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="538" mass="63237" checksum="9AE256D7E36927C6" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW86</accession>
    <name>Q5CW86_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_1260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627033.1">
        <property type="nucleotide sequence ID" value="XM_627033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW86"/>
    <dbReference type="GeneID" id="3374397"/>
    <dbReference type="KEGG" id="cpv:cgd8_1260"/>
    <dbReference type="InParanoid" id="Q5CW86"/>
    <dbReference type="OMA" id="MEYPRNT"/>
    <dbReference type="OrthoDB" id="343474at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="313"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="65"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="719" mass="83091" checksum="19414722554AAC6C" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWE6</accession>
    <name>Q5CWE6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein with signal peptide plus thr stretch, cys rich, possible mucin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_5400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627858.1">
        <property type="nucleotide sequence ID" value="XM_627858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWE6"/>
    <dbReference type="STRING" id="353152.Q5CWE6"/>
    <dbReference type="GeneID" id="3375853"/>
    <dbReference type="KEGG" id="cpv:cgd6_5400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5400"/>
    <dbReference type="InParanoid" id="Q5CWE6"/>
    <dbReference type="OMA" id="SKWQIRK"/>
    <dbReference type="OrthoDB" id="344263at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253920" evidence="2">
        <location>
            <begin position="21"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="532"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="321"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="542"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="667" mass="73338" checksum="92F583112C839992" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWJ2</accession>
    <name>Q5CWJ2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 18">Pre-mRNA-processing factor 19</fullName>
            <ecNumber evidence="5 18">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">cgd6_4850</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="18">Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 18">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subunit">
        <text evidence="18">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 18">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 18">Belongs to the WD repeat PRP19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5 18"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627812.1">
        <property type="nucleotide sequence ID" value="XM_627812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWJ2"/>
    <dbReference type="STRING" id="353152.Q5CWJ2"/>
    <dbReference type="GeneID" id="3375918"/>
    <dbReference type="KEGG" id="cpv:cgd6_4850"/>
    <dbReference type="InParanoid" id="Q5CWJ2"/>
    <dbReference type="OMA" id="SLDQHWA"/>
    <dbReference type="OrthoDB" id="687049at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070534">
        <property type="term" value="P:protein K63-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16656">
        <property type="entry name" value="RING-Ubox_PRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000027">
        <property type="entry name" value="Pre-mRNA-processing factor 19, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038959">
        <property type="entry name" value="Prp19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013915">
        <property type="entry name" value="Prp19_cc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055340">
        <property type="entry name" value="RING-Ubox_PRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43995:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08606">
        <property type="entry name" value="Prp19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 18" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15 18" id="KW-0234">DNA repair</keyword>
    <keyword evidence="19" id="KW-0472">Membrane</keyword>
    <keyword evidence="8 18" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="14 18" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="16 18" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0677">Repeat</keyword>
    <keyword evidence="10 18" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="9 18" id="KW-0808">Transferase</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="13 18" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 17" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="U-box" evidence="20">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="17">
        <location>
            <begin position="454"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00015618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU367101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EAK90173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="576" mass="65608" checksum="C81B5A0C83EBDD9A" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWK8</accession>
    <name>Q5CWK8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Prp9p-like splicing factor 3a subunit 3 snRNP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_4670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627796.1">
        <property type="nucleotide sequence ID" value="XM_627796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWK8"/>
    <dbReference type="FunCoup" id="Q5CWK8">
        <property type="interactions" value="605"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWK8"/>
    <dbReference type="GeneID" id="3375799"/>
    <dbReference type="KEGG" id="cpv:cgd6_4670"/>
    <dbReference type="InParanoid" id="Q5CWK8"/>
    <dbReference type="OMA" id="GPKAFQK"/>
    <dbReference type="OrthoDB" id="2160351at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036085">
        <property type="entry name" value="PAZ_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051421">
        <property type="entry name" value="RNA_Proc_DNA_Dmg_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024598">
        <property type="entry name" value="SF3a60/Prp9_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786:SF2">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12786">
        <property type="entry name" value="SPLICING FACTOR SF3A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11931">
        <property type="entry name" value="SF3a60_Prp9_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101690">
        <property type="entry name" value="PAZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor SF3a60 /Prp9 subunit C-terminal" evidence="4">
        <location>
            <begin position="374"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="493" mass="58117" checksum="1533A218BBE09B69" modified="2007-04-03" version="1">MVSYFDYFNIFLNNQIYIILDTKSSGSKDSLWTNFYSSIKSANSLEGVPNDLIRQSEYNIRLKALEELVIETIRGVKLDDIFIPEEDLGRRLCLEQHYSRYINLKKLKNYREATYINGELERLRRKGKAVDNSTQAGIVFEEIDFDTYLKVFDKFSSIPRYFKYKDNDYDEYITNLLEYLRDFFLRIHPLLDEGTIQTELNKDFEEEWRNGMLSDWRVPTCEMLYYSKPFDKLFFSEGTYNSHVKSKHFSRENSKYTELPNEEKDRLRGESLERDKSIARKEFFVSKFSQLLSVQRREAIDHVNKLQSSTREELEIDKQLEMENSGLETLITELNDCLNKNKSKGDRDSNKMEFDTDSDDDFDELQEKVYNPLKLPLGPDGRPMPYWLYKLNGLGIEFKCEICGNCSYWGRRAFERHFSETRHANGLSALGIPNTCHFKEITKISDAQELYSALCKQAKDLSFDDQNYVEMEDSQGNILPLKSFQDLYRQGLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWM3</accession>
    <name>Q5CWM3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative low complexity multi-pass transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_4500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627781.1">
        <property type="nucleotide sequence ID" value="XM_627781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWM3"/>
    <dbReference type="STRING" id="353152.Q5CWM3"/>
    <dbReference type="GeneID" id="3375788"/>
    <dbReference type="KEGG" id="cpv:cgd6_4500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4500"/>
    <dbReference type="InParanoid" id="Q5CWM3"/>
    <dbReference type="OMA" id="CANSSAW"/>
    <dbReference type="OrthoDB" id="2135133at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="872"/>
            <end position="893"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="900"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="953"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="991"/>
            <end position="1018"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1035" mass="119612" checksum="9D7DF3681C6EABD6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWS8</accession>
    <name>Q5CWS8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627726.1">
        <property type="nucleotide sequence ID" value="XM_627726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWS8"/>
    <dbReference type="GeneID" id="3375741"/>
    <dbReference type="KEGG" id="cpv:cgd6_3890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3890"/>
    <dbReference type="InParanoid" id="Q5CWS8"/>
    <dbReference type="OrthoDB" id="340901at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="109" mass="12938" checksum="B3B20861B0006FF8" modified="2005-04-12" version="1">MRERNSRRKIKPVYYSPSENEDSNEEIDEIESLASQDGSIRKRERIHIEEGSREINDMVESIDLTLVVWLRKMYCKYNQPYLTCLDCLEHSNYTTRLAEELLMSKFGAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWU4</accession>
    <name>Q5CWU4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative pfal-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627710.1">
        <property type="nucleotide sequence ID" value="XM_627710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWU4"/>
    <dbReference type="GeneID" id="3375730"/>
    <dbReference type="KEGG" id="cpv:cgd6_3690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3690"/>
    <dbReference type="InParanoid" id="Q5CWU4"/>
    <dbReference type="OMA" id="YETPGIC"/>
    <dbReference type="OrthoDB" id="440781at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012506">
        <property type="term" value="C:vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16118">
        <property type="entry name" value="UBX2_UBXN9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46467:SF1">
        <property type="entry name" value="TETHER CONTAINING UBX DOMAIN FOR GLUT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUB" evidence="1">
        <location>
            <begin position="123"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="501" mass="58106" checksum="65553D982A45D539" modified="2005-04-12" version="1">MGANEVEELILELGKEMGRKDQEMKIFVDTIVNKNWYDKIELLKDVTNEQWETMNIPLRLVDMIRKRIFSQVNEPKAEEDSKEEVKEILKEDDTWEFEYLTPENLEMTPSLYNSVESLGRICKEKLKAVTDILFKIIDSIIKEPRKGKIRRIKMKNPKFASTVGSFSEALNVLKSVGFVIVKLKPSQIHRISVDITKDKEEEEEEEEEEEYLELPIAYISRLTDCHHLLAIFCEKNRIEYPKLVSCDLTSIDTSGEGSVKISHFNPYVSNISSTSVSTNNDVSRKLMKSAIEERRKMESEIKKRERDMENGTIDEQNLQDSGNITCTKPFVIHSSNIQKFDNLVKAINDMESPEDFDEDDNSHFEQSEIQRIKDSILGKAPTFKSRTNEYLKSLLKRKVHSHSSIRVVFPDKYILQLQFRPNHTTYDLIQSVKDCINPNISSMNWYVYQSPPILKVIPDKKLTLLKAGFVPNAQLYFKLELPPNHTLKGNYIKAQLLNEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWW0</accession>
    <name>Q5CWW0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627694.1">
        <property type="nucleotide sequence ID" value="XM_627694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWW0"/>
    <dbReference type="GeneID" id="3375716"/>
    <dbReference type="KEGG" id="cpv:cgd6_3510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3510"/>
    <dbReference type="InParanoid" id="Q5CWW0"/>
    <dbReference type="OMA" id="KECQTIP"/>
    <dbReference type="OrthoDB" id="338956at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="199" mass="22569" checksum="A3F9414E85F525D8" modified="2007-04-03" version="1">MEGSRNYQTSDSLNFLNNTINSASTSPMLSLRYHPFENICGFTNPYYGENNGLTELELQKHSNHMRSVTDAMHYFFKLHPSIITNSPSSPRSPVIESQSPLVSPAVSSKKNRKEVEKLDVDHPNLCTTQCRVIHPNLVHSVNQRWQLRVHLLNQNSGVLKAADLSHPYVNEIINANAPITPRMTSRHTSRHISRKTTEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWX4</accession>
    <name>Q5CWX4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_3350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627680.1">
        <property type="nucleotide sequence ID" value="XM_627680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWX4"/>
    <dbReference type="GeneID" id="3375703"/>
    <dbReference type="KEGG" id="cpv:cgd6_3350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3350"/>
    <dbReference type="InParanoid" id="Q5CWX4"/>
    <dbReference type="OMA" id="NIQICEY"/>
    <dbReference type="OrthoDB" id="336210at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="390" mass="46895" checksum="DE2AD6A132371E62" modified="2005-04-12" version="1">MEDWLPEWVKIGNYELREIYIPKSKKELGICQYNILTSGNKLKKDHEWFLENRIEYSRKNGYCYFHLDLSFGEVRNPHYWRYIGIIKLYKKVQGLLSDHKEHNYLVLYMDSDTMFSRFSVRIEDFHEKMKDSFLYLSVDDNCELQHYLLNVGVLLMSLRRLETLIFCIQVLALQKTQSILSYSSEWSRSGLNDQNIVISVLNDTGRLDIENIQSYCLRKKNSSWLDNEDQWINLNYSKQNKGVVVVPSLYLNQIIRMDYIMKSSELKTNLWLERSWIIHFSGSNRLEQCFMIQKLCLDRIRKFKTKYNHYFKECPEKMEELMTKNELKKIETLFSLKMDSSLDPNNYIGQNYLVWIKDLEQIDLGIRNLSNRYSILIKRYVLIRIIERKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXF6</accession>
    <name>Q5CXF6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SCT1/Gpt2p-like glycerol-3-phosphate acyltransferase signal peptide plus 3 transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_1270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627498.1">
        <property type="nucleotide sequence ID" value="XM_627498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXF6"/>
    <dbReference type="FunCoup" id="Q5CXF6">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXF6"/>
    <dbReference type="GeneID" id="3375867"/>
    <dbReference type="KEGG" id="cpv:cgd6_1270"/>
    <dbReference type="InParanoid" id="Q5CXF6"/>
    <dbReference type="OMA" id="YTHFKDD"/>
    <dbReference type="OrthoDB" id="2427554at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004366">
        <property type="term" value="F:glycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016287">
        <property type="term" value="F:glycerone-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07992">
        <property type="entry name" value="LPLAT_AAK14816-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052744">
        <property type="entry name" value="GPAT/DAPAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31605:SF0">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="437"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="465"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="2">
        <location>
            <begin position="38"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="590" mass="67002" checksum="B78D2C93488294E0" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXN2</accession>
    <name>Q5CXN2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627422.1">
        <property type="nucleotide sequence ID" value="XM_627422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXN2"/>
    <dbReference type="GeneID" id="3376101"/>
    <dbReference type="KEGG" id="cpv:cgd6_390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_390"/>
    <dbReference type="InParanoid" id="Q5CXN2"/>
    <dbReference type="OMA" id="KNDTAND"/>
    <dbReference type="OrthoDB" id="343248at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="418"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="785"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="614"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="471"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="836"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="845" mass="100247" checksum="2396052F619CBBBF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXN4</accession>
    <name>Q5CXN4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_5530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628696.1">
        <property type="nucleotide sequence ID" value="XM_628694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXN4"/>
    <dbReference type="STRING" id="353152.Q5CXN4"/>
    <dbReference type="GeneID" id="3372023"/>
    <dbReference type="KEGG" id="cpv:cgd7_5530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5530"/>
    <dbReference type="InParanoid" id="Q5CXN4"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="101" mass="11409" checksum="1692E7C8ABF23388" modified="2005-04-12" version="1">MGSVESNVCEIIPFSSQLTCISDNLLIVNYSNHVIQQYILNSIAPLNLSNEFEYIFPCGKDIHNKEGNIRCDPITKQIQISCGSKLCKFTCNPFNLWILIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXW7</accession>
    <name>Q5CXW7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_4650</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628613.1">
        <property type="nucleotide sequence ID" value="XM_628611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXW7"/>
    <dbReference type="GeneID" id="3372188"/>
    <dbReference type="KEGG" id="cpv:cgd7_4650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4650"/>
    <dbReference type="InParanoid" id="Q5CXW7"/>
    <dbReference type="OMA" id="CINTAIW"/>
    <dbReference type="OrthoDB" id="416729at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.20">
        <property type="entry name" value="Alba-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036882">
        <property type="entry name" value="Alba-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014612">
        <property type="entry name" value="Pop7/Rpp20"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12328">
        <property type="entry name" value="Rpp20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82704">
        <property type="entry name" value="AlbA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="161" mass="18620" checksum="61290DB07E88DA1F" modified="2005-04-12" version="1">MNDVLMKVPDEVGKEEKKTRMVKKAVIPKEIKENDIYVTRKRPLIVYFRRAMNLLTVSEAHNSIYEERLGCRRNKKLFKSGKNEQFVVIHGMGACIMTAIWLVQDLKSNLGDKIKIEVTTNTIKVTDVHINEEREWESSKSTRNVSGISIKVTMNKQESRP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXX2</accession>
    <name>Q5CXX2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Mth1. SpoU superfamily-SPOUT methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628608.1">
        <property type="nucleotide sequence ID" value="XM_628606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXX2"/>
    <dbReference type="FunCoup" id="Q5CXX2">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXX2"/>
    <dbReference type="GeneID" id="3372185"/>
    <dbReference type="KEGG" id="cpv:cgd7_4590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4590"/>
    <dbReference type="InParanoid" id="Q5CXX2"/>
    <dbReference type="OMA" id="FFPIHKD"/>
    <dbReference type="OrthoDB" id="361029at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18086">
        <property type="entry name" value="HsC9orf114-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003750">
        <property type="entry name" value="Put_MeTrfase-C9orf114-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150">
        <property type="entry name" value="CLASS IV SAM-BINDING METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12150:SF13">
        <property type="entry name" value="METHYLTRANSFERASE C9ORF114-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02598">
        <property type="entry name" value="Methyltrn_RNA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="20"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="402" mass="45527" checksum="1A35289EADE6AF45" modified="2005-04-12" version="1">MDAKKTIKNRQGQSKNSPSSRERSGSRRQNESQASLQSSSEGNDDILSKIPFAGSPSKATLSVAIPASIAGNAQSFELRAYLVGQIARIISVFGVDEIIIYEDKCKDVTDNENRSSKEWVEFACSKWMEFFVKNLKYLETPQYLRKTLFKFDNDFKFAGLQNPIDAPHHMRISEWLPYRQGVIVPGPKLFKGTISPEHKNKGSWVNCGLPVEAWIETKLENNTRITIKMSKESESLHKKLCSDFNKFGRYSEIKSYFTGKLVDDSTPYRKKGIYWGYKVRPANSLKSVFNDSEYEEGYDLKIGTSERGEPVDNNFKLSTKGKDSKSQSFKHILIVFGGLGGLEDVLSDPQCSLDKVKNPSSLFDMYINICPEQRSRTIRTEEAIGLTLALLRPHLLENNKNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXY2</accession>
    <name>Q5CXY2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_4470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628598.1">
        <property type="nucleotide sequence ID" value="XM_628596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXY2"/>
    <dbReference type="STRING" id="353152.Q5CXY2"/>
    <dbReference type="GeneID" id="3372177"/>
    <dbReference type="KEGG" id="cpv:cgd7_4470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4470"/>
    <dbReference type="InParanoid" id="Q5CXY2"/>
    <dbReference type="OMA" id="IQACEAT"/>
    <dbReference type="OrthoDB" id="442453at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd14499">
        <property type="entry name" value="CDC14_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17657">
        <property type="entry name" value="CDC14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.190.10:FF:000006">
        <property type="entry name" value="Dual specificity protein phosphatase CDC14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044506">
        <property type="entry name" value="CDC14_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029260">
        <property type="entry name" value="DSPn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050561">
        <property type="entry name" value="PTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23339">
        <property type="entry name" value="TYROSINE SPECIFIC PROTEIN PHOSPHATASE AND DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14671">
        <property type="entry name" value="DSPn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="5">
        <location>
            <begin position="185"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="6">
        <location>
            <begin position="267"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="453" mass="51503" checksum="6AA55FB601F397C0" modified="2005-04-12" version="1">MNSRKKINNIIQGSLTLIENKFYWSLCTSNVPSTSVDKKGTNYYFCIDDELVYEPFFQDFGPLNLRCIYKYCKKVDNLLRTVESTGGYIVQCTSVYDMKKRTNSAFLACCYMMIRQGKTPGSSLALFNSVPLLSFRDATYGPCSYSLTVGDCLLGLYYAMLLKWFDYETFDINEYSTYEKVENGDISWVIPNKFIAFSGPSGTSVDEDGYFSLTPEFYIPIFKKLKVSTVIRLNKKQYESERFTNNGIKHEELFFIDGSCPPQNILNRFLELTENEKGVFAVHCKAGLGRTGTLLGCYAIKNYRFTASAWIGWNRIARPGSVLGPQQQFLHEIEPNLFARGSILPPEMRLDTKIPLIARKVQDAVQKQAKIRQIQCISSQFMENKNSDLSKYPITMQQNKISKDTTNNHDDISIEQEVIQMMSNLSAVDNIAILGDAGQGERLVHAKKNIISK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY52</accession>
    <name>Q5CY52_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DP1 DNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_3650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628528.1">
        <property type="nucleotide sequence ID" value="XM_628526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY52"/>
    <dbReference type="STRING" id="353152.Q5CY52"/>
    <dbReference type="GeneID" id="3372115"/>
    <dbReference type="KEGG" id="cpv:cgd7_3650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3650"/>
    <dbReference type="InParanoid" id="Q5CY52"/>
    <dbReference type="OMA" id="ISTHNDI"/>
    <dbReference type="OrthoDB" id="552115at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037241">
        <property type="entry name" value="E2F-DP_heterodim"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144074">
        <property type="entry name" value="E2F-DP heterodimerization region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="6">
        <location>
            <begin position="66"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="279" mass="31381" checksum="A0106D682B6CC0DC" modified="2005-04-12" version="1">MDYSRSLNSYINPVNTGDSLSANNVGSTGYTFEMLTTETDSVHSNQYNLDSRNNSLPYMGILGNSSNKGTLKQVAVRICTLLKVWRISTQTDIADNLIMEYLGPIDSIRAANDPIYQKNRESSEKSIRRRVYDAINVLISAKIIDKSNKNIIWKGISSINHILCSENSQSCDNLPLIQQNIREKLVEYERLQYLYLSLKTIIENNASTKAMNNGQKTLLPCCLVIANSKDSNISCIYRNNKSEVAIQVNSIVDFLDQYEIINRVAACIRMTAVDSDQLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY90</accession>
    <name>Q5CY90_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SWIB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628490.1">
        <property type="nucleotide sequence ID" value="XM_628488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY90"/>
    <dbReference type="GeneID" id="3372044"/>
    <dbReference type="KEGG" id="cpv:cgd7_3260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3260"/>
    <dbReference type="InParanoid" id="Q5CY90"/>
    <dbReference type="OMA" id="HYCEENH"/>
    <dbReference type="OrthoDB" id="339835at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="1">
        <location>
            <begin position="173"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="263" mass="30274" checksum="EEEA963DD87C1195" modified="2005-04-12" version="1">MGYRHISSDDCENSIEVDCTIVKNMQAPSQEVENHFSSIPVTSLNLEEKHEEGRTLKKIKAKEKTYTIKTVIDKHIGTDWANSRIMTNLIPSKDCIESQIAIIMSSCNLNVITLRKLYAILSICFNINLLNIDIQNVYQIIRENLLKQRKTDKQEIKKTKRVRDKKKNQIKGLIKFMGEDIVSIKSCALRIKQYCEENKLVHPSNAKIFTLDQNLKDIFPGRDSISKNVNDIQNLLKISNTEIEKECSNLHEQTINENDALKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY98</accession>
    <name>Q5CY98_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin fold protein related to phosducin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_3170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628482.1">
        <property type="nucleotide sequence ID" value="XM_628480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY98"/>
    <dbReference type="SMR" id="Q5CY98"/>
    <dbReference type="FunCoup" id="Q5CY98">
        <property type="interactions" value="268"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY98"/>
    <dbReference type="GeneID" id="3371977"/>
    <dbReference type="KEGG" id="cpv:cgd7_3170"/>
    <dbReference type="InParanoid" id="Q5CY98"/>
    <dbReference type="OMA" id="CVIAFID"/>
    <dbReference type="OrthoDB" id="10257948at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd02989">
        <property type="entry name" value="Phd_like_TxnDC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21148">
        <property type="entry name" value="THIOREDOXIN DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="107"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="217" mass="25720" checksum="0F32DA1F5699E417" modified="2005-04-12" version="1" fragment="single">INFLKALLLERLSLHLINSASKHFIDEILHGVEKKIMDSNSINVIKKVLEESENIIDEEIRAFDNIQNDENELNRLREKRIEELRQEFKQKNKFIQFGHGKYDFISDEKEFFDVIKKSENVVCHFFRPSTLRCEIFDRHLEIISKKHLEAKFIKINAEKSHFVCSNLNINILPTIALIKNSKLIHKIIGFEELSSRDNFTTTQLEELLVRRNMIQEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYA3</accession>
    <name>Q5CYA3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Pyruvate decarboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_3120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="8">Binds 1 Mg(2+) per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>thiamine diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58937"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TPP enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628477.1">
        <property type="nucleotide sequence ID" value="XM_628475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYA3"/>
    <dbReference type="STRING" id="353152.Q5CYA3"/>
    <dbReference type="GeneID" id="3371976"/>
    <dbReference type="KEGG" id="cpv:cgd7_3120"/>
    <dbReference type="InParanoid" id="Q5CYA3"/>
    <dbReference type="OMA" id="IHGPEQR"/>
    <dbReference type="OrthoDB" id="3970464at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004737">
        <property type="term" value="F:pyruvate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030976">
        <property type="term" value="F:thiamine pyrophosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000949">
        <property type="term" value="P:aromatic amino acid family catabolic process to alcohol via Ehrlich pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02005">
        <property type="entry name" value="TPP_PDC_IPDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07038">
        <property type="entry name" value="TPP_PYR_PDC_IPDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.970:FF:000024">
        <property type="entry name" value="Pyruvate decarboxylase isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.970">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012110">
        <property type="entry name" value="PDC/IPDC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029061">
        <property type="entry name" value="THDP-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012000">
        <property type="entry name" value="Thiamin_PyroP_enz_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012001">
        <property type="entry name" value="Thiamin_PyroP_enz_TPP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011766">
        <property type="entry name" value="TPP_enzyme_TPP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047214">
        <property type="entry name" value="TPP_PDC_IPDC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047213">
        <property type="entry name" value="TPP_PYR_PDC_IPDC-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43452:SF30">
        <property type="entry name" value="PYRUVATE DECARBOXYLASE ISOZYME 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02775">
        <property type="entry name" value="TPP_enzyme_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00205">
        <property type="entry name" value="TPP_enzyme_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02776">
        <property type="entry name" value="TPP_enzyme_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036565">
        <property type="entry name" value="Pyruvt_ip_decrb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52518">
        <property type="entry name" value="Thiamin diphosphate-binding fold (THDP-binding)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="7" id="KW-0456">Lyase</keyword>
    <keyword evidence="5 8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0786">Thiamine pyrophosphate</keyword>
    <feature type="domain" description="Thiamine pyrophosphate enzyme N-terminal TPP-binding" evidence="12">
        <location>
            <begin position="24"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme central" evidence="10">
        <location>
            <begin position="216"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="domain" description="Thiamine pyrophosphate enzyme TPP-binding" evidence="11">
        <location>
            <begin position="427"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="492"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR036565-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU362132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK90628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="586" mass="65729" checksum="55A8AC2CDF262D76" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYA8</accession>
    <name>Q5CYA8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_3050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628472.1">
        <property type="nucleotide sequence ID" value="XM_628470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYA8"/>
    <dbReference type="STRING" id="353152.Q5CYA8"/>
    <dbReference type="GeneID" id="3372289"/>
    <dbReference type="KEGG" id="cpv:cgd7_3050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3050"/>
    <dbReference type="InParanoid" id="Q5CYA8"/>
    <dbReference type="OMA" id="HHICIVT"/>
    <dbReference type="OrthoDB" id="9332038at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14133">
        <property type="entry name" value="PKc_DYRK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF124">
        <property type="entry name" value="PROTEIN KINASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="318"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="651" mass="75430" checksum="0AE287CBD6F2FD66" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYC3</accession>
    <name>Q5CYC3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26S proteasome regulatory subunit, inactive JAB domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_2900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M67A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628457.1">
        <property type="nucleotide sequence ID" value="XM_628455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYC3"/>
    <dbReference type="FunCoup" id="Q5CYC3">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYC3"/>
    <dbReference type="MEROPS" id="M67.973"/>
    <dbReference type="GeneID" id="3372274"/>
    <dbReference type="KEGG" id="cpv:cgd7_2900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2900"/>
    <dbReference type="InParanoid" id="Q5CYC3"/>
    <dbReference type="OMA" id="HAMSIKT"/>
    <dbReference type="OrthoDB" id="10256771at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005838">
        <property type="term" value="C:proteasome regulatory particle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08062">
        <property type="entry name" value="MPN_RPN7_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024969">
        <property type="entry name" value="EIF3F/CSN6-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033858">
        <property type="entry name" value="MPN_RPN7_8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540:SF7">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10540">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13012">
        <property type="entry name" value="MitMem_reg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MPN" evidence="3">
        <location>
            <begin position="25"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="313" mass="35468" checksum="AD16658FFBD93A7D" modified="2005-04-12" version="1">MCLSGEHSGAALYKVNSSLSNRKNIIIHPIVLLSIVDHYNRIAKGTSKRVVGTLLGELHDEDGIHVTNSYALPFEEDSRDPMVWYLDHNYHEQMYLMFKKINTKEKIIGWYSTGPKTKVVDIDIHELFRKYCPDPLYLIADVTADDFEYLSSPISAYFSMDEPNSVLKKKFAHVPCTIGAFEAEEVGVEHLLRDLKNTSTSTLITQISDTINSCKILVSKLKESKNYLNDIVEGRIPPNHSIISVLQDIFNLLPDLREPEAIYAFSNRYADMILTIYGMSCLRSVLSMNDLVNNVSENRTAFEASMKTCNSDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYG3</accession>
    <name>Q5CYG3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Giant membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_2440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628417.1">
        <property type="nucleotide sequence ID" value="XM_628415.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYG3"/>
    <dbReference type="GeneID" id="3372214"/>
    <dbReference type="KEGG" id="cpv:cgd7_2440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2440"/>
    <dbReference type="InParanoid" id="Q5CYG3"/>
    <dbReference type="OMA" id="NCEVHRE"/>
    <dbReference type="OrthoDB" id="29024at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000445">
        <property type="term" value="C:THO complex part of transcription export complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040007">
        <property type="entry name" value="Tho2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021418">
        <property type="entry name" value="THO_THOC2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021726">
        <property type="entry name" value="THO_THOC2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597:SF0">
        <property type="entry name" value="THO COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21597">
        <property type="entry name" value="THO2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11262">
        <property type="entry name" value="Tho2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11732">
        <property type="entry name" value="Thoc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THO complex subunitTHOC2 N-terminal" evidence="3">
        <location>
            <begin position="852"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="domain" description="THO complex subunitTHOC2 C-terminal" evidence="2">
        <location>
            <begin position="1204"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1727"/>
            <end position="1757"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11262"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1789" mass="209206" checksum="80916A5DFFCCEA61" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYK5</accession>
    <name>Q5CYK5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Tubulin gamma chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd7_1980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Tubulin is the major constituent of microtubules, protein filaments consisting of alpha- and beta-tubulin heterodimers. Gamma-tubulin is a key component of the gamma-tubulin ring complex (gTuRC) which mediates microtubule nucleation. The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation.</text>
    </comment>
    <comment type="function">
        <text evidence="1">Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Microtubule organizing center</location>
            <location evidence="2">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628375.1">
        <property type="nucleotide sequence ID" value="XM_628373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYK5"/>
    <dbReference type="FunCoup" id="Q5CYK5">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYK5"/>
    <dbReference type="GeneID" id="3371797"/>
    <dbReference type="KEGG" id="cpv:cgd7_1980"/>
    <dbReference type="InParanoid" id="Q5CYK5"/>
    <dbReference type="OMA" id="HRYISIL"/>
    <dbReference type="OrthoDB" id="10249382at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02188">
        <property type="entry name" value="gamma_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000004">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000049">
        <property type="entry name" value="Tubulin gamma chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002454">
        <property type="entry name" value="Gamma_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01164">
        <property type="entry name" value="GAMMATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5 9" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="10">
        <location>
            <begin position="50"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="11">
        <location>
            <begin position="252"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="492" mass="55702" checksum="6A71345FA94EFCB2" modified="2005-04-12" version="1" fragment="single">LKMPRELVTLQIGQCGNQIGMEFWKQLCTEHGLDANGTVIKDSGPLEDRKDVFFYLSDDSHYVPRALLFDLEPRVLNSIKSSEFKHLYNPENFFIGKEGGGAGNNWGCGYDTGEEVYDEILDMIDREVEGCESMEGFVLCHSIAGGTGSGMGSYILELLNEHYPRKLIKTFSVFPMLNNESSDVVVQPYNSVLTLKRLALNADCVVVLDNTALSGIAEDRLNLTNPTFAQTNALVSTVMAASTTTLRYPGYMHNNLVSLFSTLVPTPRCHFLVTSYTPITISQNIQQNVRKTTTLDVMRRLLQPSNIMVSTNMRKGTYISILNIIRGETDPMEVHKSLQRIRDRNMVRFIQWGPAAIQVALSKYNPYSTQHKVNGLMMANNTAIAGLFQRCVAQFDRLMKRGAFLDNYKKQSVFQDGLDEFENAREVSEMLIEEYKRAERNDYMLAGYNTDSGSKNLQLDGLSRQEPPLNEYSDDLYNYYSKENNPNYNTYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYM8</accession>
    <name>Q5CYM8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ing1 like PHD finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_1740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ING family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628352.1">
        <property type="nucleotide sequence ID" value="XM_628350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYM8"/>
    <dbReference type="STRING" id="353152.Q5CYM8"/>
    <dbReference type="GeneID" id="3371737"/>
    <dbReference type="KEGG" id="cpv:cgd7_1740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1740"/>
    <dbReference type="InParanoid" id="Q5CYM8"/>
    <dbReference type="OMA" id="EANACDS"/>
    <dbReference type="OrthoDB" id="340348at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028651">
        <property type="entry name" value="ING_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10333">
        <property type="entry name" value="INHIBITOR OF GROWTH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="9">
        <location>
            <begin position="294"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="371"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="386"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="295"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="321"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="324"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="337"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR628651-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="451" mass="52593" checksum="C2191F09E4B413E8" modified="2005-04-12" version="1">MSDSSISSDESDWDHSWGCPGDFSDLPGLNQDHSYPYMFSSSWYSPEDQEKKEPVYQTEFYSNNITTGFPNSVKTVPGNVVESEKEDVTPDYLDNSEFNNQGVNFFDSQIPNCRSQRLQYNTKLCIEYIEDDISRIMWNLEQQFQECVLTKDSKRQRNHGFSIEEVSEIDSVEQKKYKLRSYISILRYITMMIENCASIEMQWAKDELEMTNLLRNNISEAFMKLQKVNLSNESSNHDTVKSNDLQKNSNSLKVRKSKRIQAKVLEEEVCTVQAGSPKIEVNDFHSISDETSKFCFCKQPVLDNMIRCESGNQCIYGVWFHFLCLKIINEPQKTWYCPGCTRDEEYRALWSHIFQREALKKSIEANISKNQDETKANATPILTNSKNEKKKNSCKKERKRSKSVDGYPKKKQSRGSFFDRNNEISNYTESLNNSYDEIKREAEYKEIPQNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYN1</accession>
    <name>Q5CYN1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_1700</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628349.1">
        <property type="nucleotide sequence ID" value="XM_628347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYN1"/>
    <dbReference type="FunCoup" id="Q5CYN1">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYN1"/>
    <dbReference type="GeneID" id="3371734"/>
    <dbReference type="KEGG" id="cpv:cgd7_1700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1700"/>
    <dbReference type="InParanoid" id="Q5CYN1"/>
    <dbReference type="OMA" id="RITIEAC"/>
    <dbReference type="OrthoDB" id="1166527at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="12">
        <location>
            <begin position="32"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK90214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="131" mass="14363" checksum="BB5CF2A87ABDC01B" modified="2005-04-12" version="1">MSGKSGKSIKGPAQKQQAAKKTAGKSPADGGKRKRRKRTESFALYIYKVLKQVHPETGISKKSMSIMNSFINDVFDRLSAEAVKLVQYNKKRTLSSREVQTSVRLMLPGELSKHAVSEGTKAVTKYTSASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYN3</accession>
    <name>Q5CYN3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Nuclear pore protein RBP16/17 (RAN binding protein 16/17)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_1670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628347.1">
        <property type="nucleotide sequence ID" value="XM_628345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYN3"/>
    <dbReference type="FunCoup" id="Q5CYN3">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYN3"/>
    <dbReference type="GeneID" id="3371790"/>
    <dbReference type="KEGG" id="cpv:cgd7_1670"/>
    <dbReference type="InParanoid" id="Q5CYN3"/>
    <dbReference type="OMA" id="DCFHELC"/>
    <dbReference type="OrthoDB" id="244158at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057947">
        <property type="entry name" value="TPR_XPO7/RBP17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044189">
        <property type="entry name" value="XPO4/7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596">
        <property type="entry name" value="EXPORTIN 4,7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12596:SF2">
        <property type="entry name" value="EXPORTIN-7 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25795">
        <property type="entry name" value="TPR_XPO7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="499"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="499"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1132" mass="127711" checksum="4AB47E0C0AE73196" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYU8</accession>
    <name>Q5CYU8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Splicing factor RRM domain containing protein T22E16.120 SC35-like splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628282.1">
        <property type="nucleotide sequence ID" value="XM_628280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYU8"/>
    <dbReference type="STRING" id="353152.Q5CYU8"/>
    <dbReference type="GeneID" id="3371992"/>
    <dbReference type="KEGG" id="cpv:cgd7_940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_940"/>
    <dbReference type="InParanoid" id="Q5CYU8"/>
    <dbReference type="OMA" id="YMHQRNQ"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="90"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="286" mass="33207" checksum="74262826AB1E1E8F" modified="2005-04-12" version="1">MTFSVELGDDGIGGDNSTKKVYIDYNDGGDENREGDRKIDESKSPSRERGVSDDEQRNNEGRNEDNREPVEERDRSRSREKSEVDVSEGCSLLVRNLRFETSPGRVRHHFERYGPVRDVYLPLDYYTRRPRGFGFVEYMDPRDAQDAVNRLDGSLLDGSTIRVVVAHDRRKSPETMRRIQRDSGRGPRMGGPPSRYDHRPSGGYPPEHGYRGGRYRDDYYGGRRQGGYRDDDRNYRPKRRYSSRSPSYHSPRGRSVSRSPYRGGSISREHSHSISRDPYQGKRYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYX1</accession>
    <name>Q5CYX1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_690</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628259.1">
        <property type="nucleotide sequence ID" value="XM_628257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYX1"/>
    <dbReference type="FunCoup" id="Q5CYX1">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYX1"/>
    <dbReference type="GeneID" id="3371771"/>
    <dbReference type="KEGG" id="cpv:cgd7_690"/>
    <dbReference type="InParanoid" id="Q5CYX1"/>
    <dbReference type="OMA" id="FDSHCNI"/>
    <dbReference type="OrthoDB" id="29543at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120114">
        <property type="term" value="C:Sm-like protein family complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01730">
        <property type="entry name" value="LSm3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034105">
        <property type="entry name" value="Lsm3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040002">
        <property type="entry name" value="Sm-like_LSM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13110">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="6"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="95" mass="11075" checksum="7A58BC0A210A1FE8" modified="2005-04-12" version="1" fragment="single">LLNFLEPLDLIRLSLDEQVFVKCRGNRELKGTLYAYDPHMNMVLGNVEETYYEEESKSDTQNSEKKLKKRRIEMLFLRGDLIILVKPAVKLGKST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYY6</accession>
    <name>Q5CYY6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628244.1">
        <property type="nucleotide sequence ID" value="XM_628242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYY6"/>
    <dbReference type="GeneID" id="3371770"/>
    <dbReference type="KEGG" id="cpv:cgd7_530"/>
    <dbReference type="InParanoid" id="Q5CYY6"/>
    <dbReference type="OMA" id="PYLYYRI"/>
    <dbReference type="OrthoDB" id="10250441at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016661">
        <property type="entry name" value="PFDN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21100:SF9">
        <property type="entry name" value="PREFOLDIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="42"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="93" mass="11038" checksum="78683AA613D78CA9" modified="2005-04-12" version="1" fragment="single">IPYILNLFNLSSILLPHFIQNFIYPYLYYRIRVGESYYHASEDEATEKIEELKSQVEGRIEEISKELSSIQQEMDKLKVDLYLKFGSNINLDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYZ9</accession>
    <name>Q5CYZ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Phosphoglycerate kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628231.1">
        <property type="nucleotide sequence ID" value="XM_628229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYZ9"/>
    <dbReference type="STRING" id="353152.Q5CYZ9"/>
    <dbReference type="GeneID" id="3371899"/>
    <dbReference type="KEGG" id="cpv:cgd7_390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_390"/>
    <dbReference type="InParanoid" id="Q5CYZ9"/>
    <dbReference type="OrthoDB" id="10263927at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33477">
        <property type="entry name" value="P-LOOP NTPASE DOMAIN-CONTAINING PROTEIN LPA1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33477:SF3">
        <property type="entry name" value="P-LOOP NTPASE DOMAIN-CONTAINING PROTEIN LPA1 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="385" mass="44767" checksum="482607C65EB7E0CF" modified="2005-04-12" version="1">MAKYHQVDWEIVGIFEEDSTENHSNEFKFFDHHNPKSNLTLKDIESCFLDPNKYCKNSYNNNILKNNVILTRSWVCKLYILSGITGKDLSICMDYLENLILNNNNFSQLNRIFCYFKNLPYLISFPLSQCKFEKYLACSKNKVQKNEIIEKVNHLIKKCLIHLFSDFSVKPNIILIAGTSGSGKSTISSYLASFLRVKCVISTDTIRHVLRSTEKYKHNKALNCSTYEVHKYTTTQQTQKYKDQYSESSIVLGYLIQSSIIEDYIYEIIKNFVNKEKSIILEGVHITPSLFERIQSLANLENANLSTFLIYIQDIEEHIQRFQQRSKGILNSKYHNNIDNIREIQSYLVKTIGKLSSVTSIDNTSNNIDNIVQEKILEQVTFKFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ01</accession>
    <name>Q5CZ01_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein with a conserved N-terminal region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628229.1">
        <property type="nucleotide sequence ID" value="XM_628227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ01"/>
    <dbReference type="STRING" id="353152.Q5CZ01"/>
    <dbReference type="MEROPS" id="S09.A29"/>
    <dbReference type="GeneID" id="3371905"/>
    <dbReference type="KEGG" id="cpv:cgd7_370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_370"/>
    <dbReference type="InParanoid" id="Q5CZ01"/>
    <dbReference type="OMA" id="SERAMIK"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052920">
        <property type="entry name" value="DNA-binding_regulatory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009199">
        <property type="entry name" value="PhoPQ-act_pathogen-rel_PqaA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43358">
        <property type="entry name" value="ALPHA/BETA-HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43358:SF4">
        <property type="entry name" value="ALPHA_BETA HYDROLASE FOLD-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10142">
        <property type="entry name" value="PhoPQ_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="78"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="384"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="611" mass="67805" checksum="2FC64566CB68A42B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ27</accession>
    <name>Q5CZ27_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone acetyltransferase</fullName>
            <ecNumber evidence="2">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_60</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HAT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628203.1">
        <property type="nucleotide sequence ID" value="XM_628201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ27"/>
    <dbReference type="STRING" id="353152.Q5CZ27"/>
    <dbReference type="GeneID" id="3372029"/>
    <dbReference type="KEGG" id="cpv:cgd7_60"/>
    <dbReference type="InParanoid" id="Q5CZ27"/>
    <dbReference type="OMA" id="ACEYHAR"/>
    <dbReference type="OrthoDB" id="10253098at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031509">
        <property type="term" value="P:subtelomeric heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.360.10">
        <property type="entry name" value="Histone acetyl transferase 1 (HAT1), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019467">
        <property type="entry name" value="Hat1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037113">
        <property type="entry name" value="Hat1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017380">
        <property type="entry name" value="Hist_AcTrfase_B-typ_cat-su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12046">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE TYPE B CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10394">
        <property type="entry name" value="Hat1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Histone acetyl transferase HAT1 N-terminal" evidence="6">
        <location>
            <begin position="28"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF10394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="423" mass="49296" checksum="FFE29ABF8A35ACE4" modified="2005-04-12" version="1">MDDINPNKRVKLNEEPNSQLSIPIKIDNVLNKILLHPCETLNDFIENKVGSYAPYYAHHFFHNEEIALLDGYNTLIHIYFSCNWFDVYVEVDLTAIKSKSKEHIELSEEDKNYYIENIIKQLKTIPLEGGFCSKEEFMERLKIPLLWVPGTSAGIFKAGLRDEGIEEVDLRKIDLSETENLTSCLNKESNSSKPHPDVKNFQILHRRIEWFLHWYIESASSIDQEDRWAVWLPTVKREQSLIILGLITTYLFFSIPKSRIRISQVLIFPQYQGKGLGCSFLDIIYSFAIKDEDIMEITVEDPALSMMQLRDILTIEILLRNHVIKKDSLKPLKTDELLKILQNPNGSVNILKDVAMTCFPSQTWEEVKEKIHKYTKESPRQIARLLVLISFFRYLPNPLPKIESNIEDEIRGFRVRKGKLKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPR4</accession>
    <name>A3FPR4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prefoldin subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_4630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388410.1">
        <property type="nucleotide sequence ID" value="XM_001388373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPR4"/>
    <dbReference type="FunCoup" id="A3FPR4">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPR4"/>
    <dbReference type="GeneID" id="3371812"/>
    <dbReference type="KEGG" id="cpv:cgd7_4630"/>
    <dbReference type="InParanoid" id="A3FPR4"/>
    <dbReference type="OMA" id="CFKMIGG"/>
    <dbReference type="OrthoDB" id="29646at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23163">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027235">
        <property type="entry name" value="PFD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13303">
        <property type="entry name" value="PREFOLDIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="74"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="14661" checksum="3254F895E8BD3C0F" modified="2007-04-03" version="1" fragment="single">MNSSFPIDKERASREKISQLDRKLKVLSSKISELSQDSKEHGLVLNAFEKVDPERRCFRVIGGVMVERTVKTVKPALEKEKAALDSAISELEKQYESIEEELKTLIENLNKESNMGISSSASASSSSSEVKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPU7</accession>
    <name>A3FPU7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_2490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388326.1">
        <property type="nucleotide sequence ID" value="XM_001388289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPU7"/>
    <dbReference type="STRING" id="353152.A3FPU7"/>
    <dbReference type="GeneID" id="3375951"/>
    <dbReference type="KEGG" id="cpv:cgd6_2490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2490"/>
    <dbReference type="InParanoid" id="A3FPU7"/>
    <dbReference type="OMA" id="HEYLIIC"/>
    <dbReference type="OrthoDB" id="409931at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF8">
        <property type="entry name" value="HECT-TYPE E3 UBIQUITIN TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="468"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="765"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="797" mass="91431" checksum="ED4646907878C279" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ22</accession>
    <name>A3FQ22_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 4">Profilin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_1570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Binds to proline rich sequences in various regulatory formin-like proteins and also to membrane phospholipids. Binds to actin and affects the structure of the cytoskeleton.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Binds actin.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2 4">Belongs to the profilin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388102.1">
        <property type="nucleotide sequence ID" value="XM_001388065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ22"/>
    <dbReference type="SMR" id="A3FQ22"/>
    <dbReference type="FunCoup" id="A3FQ22">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ22"/>
    <dbReference type="GeneID" id="3374087"/>
    <dbReference type="KEGG" id="cpv:cgd3_1570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1570"/>
    <dbReference type="InParanoid" id="A3FQ22"/>
    <dbReference type="OMA" id="DKWTLFY"/>
    <dbReference type="OrthoDB" id="421374at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003785">
        <property type="term" value="F:actin monomer binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060327">
        <property type="term" value="P:cytoplasmic actin-based contraction involved in cell motility"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048278">
        <property type="entry name" value="PFN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005455">
        <property type="entry name" value="PFN_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036140">
        <property type="entry name" value="PFN_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016814">
        <property type="entry name" value="Profilin_apicomplexa"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00235">
        <property type="entry name" value="Profilin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF022993">
        <property type="entry name" value="Profilin_apicomplexa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00392">
        <property type="entry name" value="PROFILIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00392">
        <property type="entry name" value="PROF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55770">
        <property type="entry name" value="Profilin (actin-binding protein)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="2" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="site" description="Interaction with Pro-rich sequence" evidence="3">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRNR" id="PIRNR022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR022993-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003909"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="162" mass="17606" checksum="04B8ACCD9876367F" modified="2007-04-03" version="1">MSEWDDMVKEWLIDTGSVCAGGLCSIDGAFYAASADQGDAWKTLVREDHEENVIQSDGVSEAAELINDQTTLCQAISEGKAPNGVWVGGNKYKIIRVEKDFQQNDATVHVTFCNRPQGGCFLVDTQNGTVVVAVYDESKDQSSGNCKKVALQLAEYLVSQGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ57</accession>
    <name>A3FQ57_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">E3 ubiquitin protein ligase</fullName>
            <ecNumber evidence="14">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd2_880</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3 14">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the BRE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="14"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388193.1">
        <property type="nucleotide sequence ID" value="XM_001388156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ57"/>
    <dbReference type="STRING" id="353152.A3FQ57"/>
    <dbReference type="GeneID" id="3373426"/>
    <dbReference type="KEGG" id="cpv:cgd2_880"/>
    <dbReference type="InParanoid" id="A3FQ57"/>
    <dbReference type="OrthoDB" id="10266039at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033503">
        <property type="term" value="C:HULC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd16499">
        <property type="entry name" value="RING-HC_Bre1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013956">
        <property type="entry name" value="E3_ubiquit_lig_Bre1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE BRE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23163">
        <property type="entry name" value="RING FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="11 14 15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="9 14" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 13 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="17">
        <location>
            <begin position="580"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="116"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="306"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="550"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAZ51366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="633" mass="74703" checksum="36458E6EE11D7942" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ62</accession>
    <name>A3FQ62_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase</fullName>
            <ecNumber evidence="10">2.7.8.5</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd2_1110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>a CDP-1,2-diacyl-sn-glycerol + sn-glycerol 3-phosphate = a 1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycero-3'-phosphate) + CMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12593"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:60110"/>
            <dbReference type="ChEBI" id="CHEBI:60377"/>
            <dbReference type="EC" id="2.7.8.5"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Phospholipid metabolism; phosphatidylglycerol biosynthesis; phosphatidylglycerol from CDP-diacylglycerol: step 1/2.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the CDP-alcohol phosphatidyltransferase class-II family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.5" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388198.1">
        <property type="nucleotide sequence ID" value="XM_001388161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ62"/>
    <dbReference type="FunCoup" id="A3FQ62">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ62"/>
    <dbReference type="GeneID" id="3373421"/>
    <dbReference type="KEGG" id="cpv:cgd2_1110"/>
    <dbReference type="InParanoid" id="A3FQ62"/>
    <dbReference type="OMA" id="CLANINE"/>
    <dbReference type="OrthoDB" id="10250191at2759"/>
    <dbReference type="UniPathway" id="UPA00084">
        <property type="reaction ID" value="UER00503"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008444">
        <property type="term" value="F:CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09137">
        <property type="entry name" value="PLDc_PGS1_euk_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016270">
        <property type="entry name" value="PGS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586:SF1">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12586">
        <property type="entry name" value="CDP-DIACYLGLYCEROL--SERINE O-PHOSPHATIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="11">
        <location>
            <begin position="61"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="398" mass="46274" checksum="C1D03D92B1198A4C" modified="2007-04-03" version="1">MTRKENINPFIKALNKYPNSVVISLCKIPIVNYSGNLLGRATWNVINIFSKYKRVSFLKEVLGVYHIKIFMADDNIIITSANLNSEYLLNKQDRYIMITGAKEICDYFEQSLDLISEYSHRVLSEGEIQKPKKLHFNELKRDLMELSSDADFHDKIASTIKKKLNNEDASDDCVLASYFQCSPINIKAEEQIITNISQLCDKKNTDIFLIAPYLNLPKYFISLLKNRERSVNIVSGVPITKCDKMIKKHNKPSLERIRTLVLPKLYTYINYLFINQLRTQGNGIINYFEYKKPNWSFHFKGIYFFRNISKSNPCGSNMQNQGQIMATTFGSSNYNYRSTNKDFECSFVLIPNQNKILEKSLNNELTNIMNTSVKQCAPKITWRRLLILKVVKIFQEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ80</accession>
    <name>A3FQ80_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388216.1">
        <property type="nucleotide sequence ID" value="XM_001388179.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373440"/>
    <dbReference type="KEGG" id="cpv:cgd2_1970"/>
    <dbReference type="InParanoid" id="A3FQ80"/>
    <dbReference type="OrthoDB" id="338675at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="unsure residue" description="I or L" evidence="1">
        <location>
            <position position="930"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAZ51389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="962" mass="110929" checksum="4AD368BFBDF4D0E2" modified="2013-05-29" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ85</accession>
    <name>A3FQ85_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Trm112p-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_2440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRM112 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388221.1">
        <property type="nucleotide sequence ID" value="XM_001388184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ85"/>
    <dbReference type="FunCoup" id="A3FQ85">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ85"/>
    <dbReference type="GeneID" id="3373551"/>
    <dbReference type="KEGG" id="cpv:cgd2_2440"/>
    <dbReference type="InParanoid" id="A3FQ85"/>
    <dbReference type="OMA" id="NMLTSKC"/>
    <dbReference type="OrthoDB" id="2187549at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039127">
        <property type="entry name" value="Trm112"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005651">
        <property type="entry name" value="Trm112-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773:SF0">
        <property type="entry name" value="MULTIFUNCTIONAL METHYLTRANSFERASE SUBUNIT TRM112-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12773">
        <property type="entry name" value="UPF0315 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03966">
        <property type="entry name" value="Trm112p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158997">
        <property type="entry name" value="Trm112p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14818" checksum="87D74C0FBF97BB83" modified="2007-04-03" version="1" fragment="single">LHEYKISIFNNLSNRSECRNGFPLEISLNGSVEESTKMLDVEFNIEQIKQIIKKVDWGVLVKSASQFGLSLPLSYSEQDFDDEVFLCAVHDAILRFQIMEAELICPICNHRYIVSKGVPDMIFSSLVSKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQE3</accession>
    <name>A3FQE3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Unnamed protein product</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_2310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388165.1">
        <property type="nucleotide sequence ID" value="XM_001388128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQE3"/>
    <dbReference type="STRING" id="353152.A3FQE3"/>
    <dbReference type="GeneID" id="3371405"/>
    <dbReference type="KEGG" id="cpv:cgd1_2310"/>
    <dbReference type="InParanoid" id="A3FQE3"/>
    <dbReference type="OMA" id="WTFIMDI"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07323">
        <property type="entry name" value="LAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045180">
        <property type="entry name" value="La_dom_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22792">
        <property type="entry name" value="LUPUS LA PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="3">
        <location>
            <begin position="9"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="163" mass="19043" checksum="E2AD4E521D3ED970" modified="2007-04-03" version="1" fragment="single">NLVDWTFIMDIEKNKLDKIKQQIEFYFSDSNIRHDKYFRSKLTEYKYLHNFGIPISLISTFNKMIELNASVQDIINSLSSSKVVFVNIETLTIHRFKPINIDLCTVIPRDKMLFIKSIPTKWNHNNVKSLLGRFGKVSVVKLPKINKSNTRRLVDLEPILCLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQE7</accession>
    <name>A3FQE7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_2490</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388169.1">
        <property type="nucleotide sequence ID" value="XM_001388132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQE7"/>
    <dbReference type="FunCoup" id="A3FQE7">
        <property type="interactions" value="527"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQE7"/>
    <dbReference type="MEROPS" id="T01.A14"/>
    <dbReference type="GeneID" id="3371400"/>
    <dbReference type="KEGG" id="cpv:cgd1_2490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2490"/>
    <dbReference type="InParanoid" id="A3FQE7"/>
    <dbReference type="OMA" id="CSGCWCD"/>
    <dbReference type="OrthoDB" id="268479at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000027">
        <property type="entry name" value="Proteasome subunit beta type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="246" mass="26831" checksum="4038E1190F2AC1CD" modified="2007-04-03" version="1">MYSLTKNRDPIQIEGFCGQLISETEKKSYNGKIEHSFNPYMNNGGSCVAVAGDDFVVIAADTRLSKMYRIASRSVSKTCQLTNKCILACSGMLADINALRKTLLAKVKLYEFEHNKTPSINAIAQLLSCILYSKRFFPYYSFCLLSGLDEQGKGVVYGYDAVGSFDQHKFVALGSGGSLITSILDNQISGNNQTSFESIDKVGIINIVKDSITSASERDVHTGDSAEVIVIDSSGISVSSLRLRED</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQK7</accession>
    <name>A3FQK7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Dipeptidyl peptidase 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Cathepsin C</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Cathepsin J</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="14">Dipeptidyl peptidase I</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Dipeptidyl transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd4_2110</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Thiol protease. Has dipeptidylpeptidase activity. Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids. Proline cannot occupy the P1 position and arginine cannot occupy the P2 position of the substrate. Can act as both an exopeptidase and endopeptidase. Activates serine proteases such as elastase, cathepsin G and granzymes A and B.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388062.1">
        <property type="nucleotide sequence ID" value="XM_001388025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQK7"/>
    <dbReference type="SMR" id="A3FQK7"/>
    <dbReference type="FunCoup" id="A3FQK7">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQK7"/>
    <dbReference type="GeneID" id="3372828"/>
    <dbReference type="KEGG" id="cpv:cgd4_2110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2110"/>
    <dbReference type="InParanoid" id="A3FQK7"/>
    <dbReference type="OMA" id="NAVQKSW"/>
    <dbReference type="OrthoDB" id="640249at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02621">
        <property type="entry name" value="Peptidase_C1A_CathepsinC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.80">
        <property type="entry name" value="Cathepsin C, exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039412">
        <property type="entry name" value="CatC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014882">
        <property type="entry name" value="CathepsinC_exc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036496">
        <property type="entry name" value="CathepsinC_exc_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08773">
        <property type="entry name" value="CathepsinC_exc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75001">
        <property type="entry name" value="Dipeptidyl peptidase I (cathepsin C), exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="8" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5018528095" description="Dipeptidyl peptidase 1" evidence="16">
        <location>
            <begin position="22"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="17">
        <location>
            <begin position="331"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00014709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00029779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00032961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00045556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAZ51250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="635" mass="71985" checksum="0DAA9605485ABEAD" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQR7</accession>
    <name>A3FQR7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAZ51209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388298.1">
        <property type="nucleotide sequence ID" value="XM_001388261.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3375660"/>
    <dbReference type="KEGG" id="cpv:cgd6_350"/>
    <dbReference type="InParanoid" id="A3FQR7"/>
    <dbReference type="OMA" id="NCISWDI"/>
    <dbReference type="OrthoDB" id="337476at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="188" mass="21986" checksum="CB808EDB775BF32C" modified="2007-04-03" version="1" fragment="single">VIIIGINGDNIQNNTLNNTXNHINNNNNNNNNIINNNTNNTNNINTNTNNNNNNDNDDNDNKTEQDDINQVFKDINGIPWIGIWRWDLYEKKRGKLILIYSIINQTNYPTNCISWDIKGTEFITCTEYNITRFIQSNNINTNDQIDDDLRCISYQXXXLIFHGTQLKEQKDKFIINDFPLFVKFIRPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPI5</accession>
    <name>Q5CPI5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Acyltransferase</fullName>
            <ecNumber evidence="14">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd6_260</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycerolipid metabolism; triacylglycerol biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Endoplasmic reticulum membrane</location>
            <topology evidence="1 14">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 14">Belongs to the diacylglycerol acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="14"/>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625364.1">
        <property type="nucleotide sequence ID" value="XM_625364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPI5"/>
    <dbReference type="STRING" id="353152.Q5CPI5"/>
    <dbReference type="GeneID" id="3375644"/>
    <dbReference type="KEGG" id="cpv:cgd6_260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_260"/>
    <dbReference type="InParanoid" id="Q5CPI5"/>
    <dbReference type="OMA" id="IMGVACT"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006071">
        <property type="term" value="P:glycerol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007130">
        <property type="entry name" value="DAGAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317:SF0">
        <property type="entry name" value="ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12317">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03982">
        <property type="entry name" value="DAGAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="9 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0319">Glycerol metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="38"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="69"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="145"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU367023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK87349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="383" mass="44674" checksum="410A3FF69DC280AF" modified="2005-04-12" version="1">MENAKNEILIKESDCKIKIIDIPVDFQQGGIRPILGCISYTILILTWGISILIPVGLVYWFFLGNWNMIILLLTIILVPIIFNWHDNVPGVIKYLSNLLTKDVHHWTGKLINFYSLFLIIIFILILGPGKIIIEDPDFDVNSKQLLCLHPHGILGIGSMYIIISGIFSKLHLIVTESLVWLQPIISVILNSTVKLRGASHFSFKQTMKREEGPLVMFPGGFHETILLNWGKDAVFIERRFGFIKYCLKYNYLIRPVYVFGECLSFHQFQHFKRFRWILNDFSLPSVIFCGETWWNPLLPLRNVPYLIVIGKPINSDIINNSYNSKLNNNNNPSREMVKKYHSLYIQNLKRIYTQYSPFYQSFFNDHPLLERYIQNKSKELTIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPK6</accession>
    <name>Q5CPK6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_30</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625343.1">
        <property type="nucleotide sequence ID" value="XM_625343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPK6"/>
    <dbReference type="GeneID" id="3375663"/>
    <dbReference type="KEGG" id="cpv:cgd6_30"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_30"/>
    <dbReference type="InParanoid" id="Q5CPK6"/>
    <dbReference type="OrthoDB" id="339886at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254082" evidence="1">
        <location>
            <begin position="20"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="273" mass="32442" checksum="45C66A7175F2DEC7" modified="2007-04-03" version="1">MKIFEILFLFATYFLTKTGFRNSESISNFSLLSLKEGIQEKNETKEYYSKYNITERVPTLFTNILILDMNPSEESRNSHLFKYSNTSYALDCYQKLPQYSIIIGLVKEYSYFLSVYYRLRCENGNEYHDGTKCGDILYLVDLLENKAEILKEKKNLKKNKCFTIESNIVSTQYRFYNHTGFVGRAGKALVESEFVLVEKSFLRRVMSEFEQLLISKTISYELHCISKLENKEEGEVDCYRLRLENWILEQELVLISEEYFKRMSRFERLKDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPL0</accession>
    <name>Q5CPL0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide, serine proline rich, possible low mw mucin glycoprotein locus of 6 genes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625411.1">
        <property type="nucleotide sequence ID" value="XM_625411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPL0"/>
    <dbReference type="STRING" id="353152.Q5CPL0"/>
    <dbReference type="GeneID" id="3372377"/>
    <dbReference type="KEGG" id="cpv:cgd2_440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_440"/>
    <dbReference type="InParanoid" id="Q5CPL0"/>
    <dbReference type="OrthoDB" id="344246at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="134" mass="15316" checksum="10D0ABBD9E9D7BA5" modified="2005-04-12" version="1">MNYQKLLMNLCIVVGLLSYFMIYSDHEIEFTNEKYNEFSLLQMNIPSRLPTLLRGCRKLFGSPSYKPKTIDFSSFDGTRPKPKSSLPRNIQSVNHHLLSSPPLPKKPPVGDPYNPERSAALLSRKLKGVYNSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPP0</accession>
    <name>Q5CPP0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="5">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="5">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="5"/>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625381.1">
        <property type="nucleotide sequence ID" value="XM_625381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPP0"/>
    <dbReference type="FunCoup" id="Q5CPP0">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPP0"/>
    <dbReference type="GeneID" id="3372349"/>
    <dbReference type="KEGG" id="cpv:cgd2_110"/>
    <dbReference type="InParanoid" id="Q5CPP0"/>
    <dbReference type="OMA" id="HEVKAFD"/>
    <dbReference type="OrthoDB" id="3370at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="61"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="323"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="528" mass="61044" checksum="977E2BEA69EC847B" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPS7</accession>
    <name>Q5CPS7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_4210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625437.1">
        <property type="nucleotide sequence ID" value="XM_625437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPS7"/>
    <dbReference type="GeneID" id="3372399"/>
    <dbReference type="KEGG" id="cpv:cgd4_4210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4210"/>
    <dbReference type="InParanoid" id="Q5CPS7"/>
    <dbReference type="OMA" id="IYAYNIV"/>
    <dbReference type="OrthoDB" id="341279at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254095" evidence="1">
        <location>
            <begin position="27"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="784" mass="91510" checksum="246CC69288840A46" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPW8</accession>
    <name>Q5CPW8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Caltractin, centrin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625511.1">
        <property type="nucleotide sequence ID" value="XM_625511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPW8"/>
    <dbReference type="STRING" id="353152.Q5CPW8"/>
    <dbReference type="GeneID" id="3372474"/>
    <dbReference type="KEGG" id="cpv:cgd8_500"/>
    <dbReference type="InParanoid" id="Q5CPW8"/>
    <dbReference type="OMA" id="CMDIPLD"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="85"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="121"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="157" mass="17271" checksum="F11D5ABB49159073" modified="2005-04-12" version="1" fragment="single">YWQFDFILKKMDSTEVRELRDVFDLLDGKSGLDVGFLRAAATCMDIPLDNTVIGRLNSLTQECGGKLDFAGFVSLVNSGNEIKKFTVEDAVNIFSCLDIKKTGTIDLEDLSACASRLGLSMSEEELKTMLTNLDGDGDNAISPDDLLSALHRYSEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ41</accession>
    <name>Q5CQ41_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">EGF-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd5_4230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625585.1">
        <property type="nucleotide sequence ID" value="XM_625585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ41"/>
    <dbReference type="STRING" id="353152.Q5CQ41"/>
    <dbReference type="GeneID" id="3372569"/>
    <dbReference type="KEGG" id="cpv:cgd5_4230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4230"/>
    <dbReference type="InParanoid" id="Q5CQ41"/>
    <dbReference type="OMA" id="CINLMEY"/>
    <dbReference type="OrthoDB" id="69646at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021910">
        <property type="entry name" value="NGX6/PGAP6/MYMK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14319">
        <property type="entry name" value="FIVE-SPAN TRANSMEMBRANE PROTEIN M83"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14319:SF3">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12036">
        <property type="entry name" value="DUF3522"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254826" description="EGF-like domain-containing protein" evidence="10">
        <location>
            <begin position="29"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="673"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="700"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="757"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="782"/>
            <end position="801"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="935"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="958"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="11">
        <location>
            <begin position="624"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="834"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="834"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="654"/>
            <end position="663"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005542"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK87570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1029" mass="117533" checksum="53514AF0AD670DC4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ55</accession>
    <name>Q5CQ55_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Articulin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_4080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625571.1">
        <property type="nucleotide sequence ID" value="XM_625571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ55"/>
    <dbReference type="STRING" id="353152.Q5CQ55"/>
    <dbReference type="GeneID" id="3372523"/>
    <dbReference type="KEGG" id="cpv:cgd5_4080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4080"/>
    <dbReference type="InParanoid" id="Q5CQ55"/>
    <dbReference type="OMA" id="MSHECNS"/>
    <dbReference type="OrthoDB" id="448535at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022086">
        <property type="entry name" value="IMCp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12314">
        <property type="entry name" value="IMCp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="437"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="451" mass="51902" checksum="3036DD373E7B4B57" modified="2005-04-12" version="1">MNSCNSLGLCSAESESPILQHNYDSVDTNGNTSFGRTNMSRRDDFCCMSDRNVEDNENDSFIPQDCCSSNPRIVEDSNQDSVSSPGGNAQIVTVPLVQEVNVRDRIIEVPEVHITQKIRQKVIVKDVIRKVPKQEIQYVDKFVEVPEVRIVDKFVSKPVTKYVERHVPKVEVREIVKEIPKIEIQYVEKIVEVPEIRVVDKIVEIPTIKHVIKEVPKIEIKEIQVEKIVKVPKIEIKQIEKERKVLGPVEYIDIPIEKIILKPNPQIIEKIVQVPIPKEVEIEVPVYNPDIRDTVEIEVDNYYTVEKEVEVPIPGRIIPVPVEVEVEKIVEVPVQVPQEHIRIVQKQVPQYIEHIRTVEIPQYQDEFVEVPQYVPMVHHTIIKPVVSQEYKELPPVVEQGDVRYVKEPPQYLETEYIHGEPIELDCNTPLPAPPSPRYTTIKVNSANNRDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ63</accession>
    <name>Q5CQ63_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein with 4 transmembrane domains, signal peptide and a RING domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_3990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625563.1">
        <property type="nucleotide sequence ID" value="XM_625563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ63"/>
    <dbReference type="GeneID" id="3372515"/>
    <dbReference type="KEGG" id="cpv:cgd5_3990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3990"/>
    <dbReference type="InParanoid" id="Q5CQ63"/>
    <dbReference type="OMA" id="YFRIHEV"/>
    <dbReference type="OrthoDB" id="342608at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="189"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="269"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="315"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="546"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="656"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="730" mass="84045" checksum="2E5681736D795448" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQH8</accession>
    <name>Q5CQH8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nip7 like PUA domain containing protein involved in ribosomal biogenesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NIP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625670.1">
        <property type="nucleotide sequence ID" value="XM_625670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQH8"/>
    <dbReference type="FunCoup" id="Q5CQH8">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQH8"/>
    <dbReference type="GeneID" id="3372657"/>
    <dbReference type="KEGG" id="cpv:cgd4_660"/>
    <dbReference type="InParanoid" id="Q5CQH8"/>
    <dbReference type="OMA" id="LISMGTC"/>
    <dbReference type="OrthoDB" id="27490at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042255">
        <property type="term" value="P:ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd21146">
        <property type="entry name" value="Nip7_N_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21151">
        <property type="entry name" value="PUA_Nip7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.130.10:FF:000002">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.220:FF:000001">
        <property type="entry name" value="60S ribosome subunit biogenesis protein NIP7 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040598">
        <property type="entry name" value="NIP7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055359">
        <property type="entry name" value="Nip7_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016686">
        <property type="entry name" value="Ribosomal_synth_fac_NIP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005155">
        <property type="entry name" value="UPF0113_PUA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17833">
        <property type="entry name" value="pre-PUA_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03657">
        <property type="entry name" value="UPF0113"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017190">
        <property type="entry name" value="Rbsml_synth_fac_NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88802">
        <property type="entry name" value="Pre-PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="PUA" evidence="6">
        <location>
            <begin position="98"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="183" mass="20624" checksum="9753B51B80E722B6" modified="2005-04-12" version="1" fragment="single">KVKMRPLTEEETKILFEKLSNYLGNNLLSLLEREDESYVFRLHKGNVFYMSETLAKAASIVPKKSLLSMGTCLGKFSKNNKFRLGITSLQYIARLTPNKVWVKPGGEQSYIYGNHVIKRHISRMTDGLSNNVGVVVYSMDELPLGFGVLAKSSADMKNADPETIAVYHQTDVGEYLREEADLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQL2</accession>
    <name>Q5CQL2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">E3 UFM1-protein ligase 1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625636.1">
        <property type="nucleotide sequence ID" value="XM_625636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQL2"/>
    <dbReference type="STRING" id="353152.Q5CQL2"/>
    <dbReference type="GeneID" id="3372712"/>
    <dbReference type="KEGG" id="cpv:cgd4_280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_280"/>
    <dbReference type="InParanoid" id="Q5CQL2"/>
    <dbReference type="OMA" id="NEINYIW"/>
    <dbReference type="OrthoDB" id="10258297at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061666">
        <property type="term" value="F:UFM1 ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032434">
        <property type="term" value="P:regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018611">
        <property type="entry name" value="Ufl1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056579">
        <property type="entry name" value="Ufl1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31057:SF0">
        <property type="entry name" value="E3 UFM1-PROTEIN LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09743">
        <property type="entry name" value="E3_UFM1_ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="556"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="domain" description="E3 UFM1-protein ligase 1-like N-terminal" evidence="2">
        <location>
            <begin position="4"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="595" mass="70919" checksum="3C1B9B101A84C857" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQQ9</accession>
    <name>Q5CQQ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_3670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625943.1">
        <property type="nucleotide sequence ID" value="XM_625943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQQ9"/>
    <dbReference type="STRING" id="353152.Q5CQQ9"/>
    <dbReference type="GeneID" id="3372806"/>
    <dbReference type="KEGG" id="cpv:cgd4_3670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3670"/>
    <dbReference type="InParanoid" id="Q5CQQ9"/>
    <dbReference type="OrthoDB" id="344319at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637">
        <property type="entry name" value="COLLAGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24637:SF422">
        <property type="entry name" value="COLLAGEN IV NC1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="76"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="468" mass="50770" checksum="CEC86A29C9172AF3" modified="2005-04-12" version="1">MGVNCLLKVNFNKYFLLVVTIIVYFNNLMFNNEEKLNASIASYNFNFPEIEDNSQNYIFFPQSFLNLSLKNNISKGSSGDEGLGSNSRSRTSSASRSRSVSSTGSTRPTGSTGPAGSTGPAGSTGPAGSTRQTRSTGRTSSTGSTGQTGSTGSTRQARSTGRTGSTGATRQTNPTGSTSQTRSTRRTGSTGPTRQTNPTGSAGSAGSTGPAGPEERERNTTPENFSESYENEFKRLQKIDASYTEKEKVLVTCQQLIDWSELLSLLLDMFVIKASDLDSSTALEECLAKLLEIGEIKNLSLYPGNRGSSLLLKAIKKVSSALSSRNSLEKKLQDLLASTVSLQDMLSSLILDCTASATQVILLSHLQYSRLTSTYNELNTRIEDVTSLNSHLKTVDANFCDETFISNIKYLIVNMKKKVRFKDESSSSSKTKKQTSKKHSSQSAVRKHYMKHTLSSSAKVRKKYNGDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQS3</accession>
    <name>Q5CQS3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_3530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625929.1">
        <property type="nucleotide sequence ID" value="XM_625929.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372860"/>
    <dbReference type="KEGG" id="cpv:cgd4_3530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3530"/>
    <dbReference type="InParanoid" id="Q5CQS3"/>
    <dbReference type="OMA" id="NIINFAM"/>
    <dbReference type="OrthoDB" id="342351at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254844" evidence="3">
        <location>
            <begin position="31"/>
            <end position="1578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="361"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1231"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1349"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="52"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1231"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1243"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1357"/>
            <end position="1368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1578" mass="175386" checksum="AC71533C26B067EB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQV1</accession>
    <name>Q5CQV1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Rrp3p, eIF4A-1-family RNA SFII helicase (DEXDc+HELICc)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd4_3180</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625901.1">
        <property type="nucleotide sequence ID" value="XM_625901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQV1"/>
    <dbReference type="FunCoup" id="Q5CQV1">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQV1"/>
    <dbReference type="GeneID" id="3372938"/>
    <dbReference type="KEGG" id="cpv:cgd4_3180"/>
    <dbReference type="InParanoid" id="Q5CQV1"/>
    <dbReference type="OMA" id="GIGIKCC"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17954">
        <property type="entry name" value="DEADc_DDX47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044765">
        <property type="entry name" value="DDX47/Rrp3_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF20">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="64"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="266"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK87922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="446" mass="49954" checksum="0C65C48221CE107A" modified="2005-04-12" version="1" fragment="single">ATRVEMKNKSTEFLESHVSKIAEHVEEESSESVTFASLGVCKELCIACESLGWKTPTEIQKKTIPVALEGRDIIGLAETGSGKTGSFIIPILQRLLDDQVPMYAVILAPTRELCVQISEQFSAFGSLISLKIATLVGGLDMVMQSLSLAKKPHIIVASPGRLVDHLENTKGFNIGGIKFLVMDEADRLLSMDFEIALNKIVESSPRNRTTYLFSATMTTKVAKLQKISLSNPIKICVNTKYDTAANLMQYYMFIPFKYKWSYFIGMLQNLGQYTGIIFCNTCINCRRGDLLAKELGFNSISLHGRMSQSQRLSALNLFKGKQKRLLFTTEVGSRGLDIPHVDFVINFDIPTSSKDYVHRVGRTARAGRSGRAISMVTQYDVETFQRIEFALNRKLDEYTSLQREEVMAIHAKVVDSLRTVDAELNDSNEKTALVGHRKLKNRNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRB6</accession>
    <name>Q5CRB6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleotidase (5'-nucleotidase/2'-cyclic phosphodiesterase) of the calcineurin superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_3460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 5'-nucleotidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626270.1">
        <property type="nucleotide sequence ID" value="XM_626270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRB6"/>
    <dbReference type="SMR" id="Q5CRB6"/>
    <dbReference type="STRING" id="353152.Q5CRB6"/>
    <dbReference type="DNASU" id="3373059"/>
    <dbReference type="GeneID" id="3373059"/>
    <dbReference type="KEGG" id="cpv:cgd5_3460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3460"/>
    <dbReference type="InParanoid" id="Q5CRB6"/>
    <dbReference type="OMA" id="GETWYDF"/>
    <dbReference type="OrthoDB" id="10252235at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009166">
        <property type="term" value="P:nucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.780.10">
        <property type="entry name" value="5'-Nucleotidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008334">
        <property type="entry name" value="5'-Nucleotdase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036907">
        <property type="entry name" value="5'-Nucleotdase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006179">
        <property type="entry name" value="5_nucleotidase/apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575:SF48">
        <property type="entry name" value="5'-NUCLEOTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11575">
        <property type="entry name" value="5'-NUCLEOTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02872">
        <property type="entry name" value="5_nucleotid_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01607">
        <property type="entry name" value="APYRASEFAMLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55816">
        <property type="entry name" value="5'-nucleotidase (syn. UDP-sugar hydrolase), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="5">
        <location>
            <begin position="84"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="5'-Nucleotidase C-terminal" evidence="6">
        <location>
            <begin position="417"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="9"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU362119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02872"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="710" mass="80348" checksum="0A930C5E839E390C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRD5</accession>
    <name>Q5CRD5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_3240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626251.1">
        <property type="nucleotide sequence ID" value="XM_626251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRD5"/>
    <dbReference type="GeneID" id="3373044"/>
    <dbReference type="KEGG" id="cpv:cgd5_3240"/>
    <dbReference type="InParanoid" id="Q5CRD5"/>
    <dbReference type="OrthoDB" id="6238971at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="327" mass="38454" checksum="C21A0F3A08A4E051" modified="2005-04-12" version="1">MIPPIKPKYIFLLKYKHNNNNLDNETSLIPEIILKSKKCRFMIHILAINYKGKHKEQFEKQIKSYIKDDFWINYNFLNDSSDKFKDPEELMSQYALFKTPQIFHEYVDKTFLAINKIPNSHYLCKTEEKSFKTYNTGESYNYNNNNIFGMDLGIDFGLNNGFDINNSFNQQIKTSGMTTTSTSTTYSSTDTFDSENNQINGRIVTNNNFFDPISGIHTRNKFLWCIEILHQFYYLNLDLLRMEKKRIEKSVKNDNISSQEIFNSECYKIPPIFNEQAEGVEMETDAETDVDNNTDHAELDDEDSFNNEINHNDHVNGNIHIQNKLYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRI8</accession>
    <name>Q5CRI8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)</fullName>
            <ecNumber evidence="2">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_2610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626198.1">
        <property type="nucleotide sequence ID" value="XM_626198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRI8"/>
    <dbReference type="STRING" id="353152.Q5CRI8"/>
    <dbReference type="GeneID" id="3373204"/>
    <dbReference type="KEGG" id="cpv:cgd5_2610"/>
    <dbReference type="InParanoid" id="Q5CRI8"/>
    <dbReference type="OMA" id="LWNTDIY"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="281"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="283"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="5">
        <location>
            <position position="23"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="22"/>
            <end position="29"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="373" mass="42952" checksum="154BDE6D984731B9" modified="2005-04-12" version="1" fragment="single">FLNVNIERMMYKNMPVDLVLVRHGQSEGNLAQRLARQGELHTWTGEFRRRHNSQYRLTDRGRAQARIAGEYIKNNIGFTFDKCFTSEYVRAMETAAMLGLPNALWNTDIYLRERDRGVLANKTHQERVLLHPDEMVRKQRNAFYWQPSGGESLANLCLRIERVLDNLSQNCGGLRVIIVCHGGVIKSFRALLESERGDVNTKINKINNCQIVWYTRRDPEKGSIANSYNWVKSVCPWDLSLSSNTWKHIHRPTFTNEDLLQIIQKVPQLVNAPVLDIMEDSDNSSPIEFSPNHEGNNSSVKKNTTAETSEELCEHNFNASTNGSKQNISNSDYTDEEILDDSDIQEDDDLIDFNPQIFVSKYFKDYNTQDNID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRM7</accession>
    <name>Q5CRM7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S13</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_2210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626159.1">
        <property type="nucleotide sequence ID" value="XM_626159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRM7"/>
    <dbReference type="FunCoup" id="Q5CRM7">
        <property type="interactions" value="330"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRM7"/>
    <dbReference type="GeneID" id="3373342"/>
    <dbReference type="KEGG" id="cpv:cgd5_2210"/>
    <dbReference type="InParanoid" id="Q5CRM7"/>
    <dbReference type="OMA" id="MHTRRKG"/>
    <dbReference type="OrthoDB" id="623277at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070181">
        <property type="term" value="F:small ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00353">
        <property type="entry name" value="Ribosomal_S15p_S13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.10:FF:000003">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.130:FF:000001">
        <property type="entry name" value="40S ribosomal protein S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01343_A">
        <property type="entry name" value="Ribosomal_uS15_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000589">
        <property type="entry name" value="Ribosomal_uS15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023029">
        <property type="entry name" value="Ribosomal_uS15_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012606">
        <property type="entry name" value="Ribosomal_uS15_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009068">
        <property type="entry name" value="uS15_NS1_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006331">
        <property type="entry name" value="PRK08561.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885">
        <property type="entry name" value="RIBOSOMAL PROTEIN S15P/S13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11885:SF6">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08069">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00312">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01386">
        <property type="entry name" value="Ribosomal_S13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01387">
        <property type="entry name" value="Ribosomal_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47060">
        <property type="entry name" value="S15/NS1 RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00362">
        <property type="entry name" value="RIBOSOMAL_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS15 N-terminal" evidence="6">
        <location>
            <begin position="4"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="154" mass="17508" checksum="9C7E9B4C6FAD85C1" modified="2005-04-12" version="1" fragment="single">RGKMGRVYGRGKGISSSAKPYRRRPPTWIKLKPSEAEDLITKLARKGLTPSQIGVTLRDSHGIPMVQSLTGSKILRILKKNGLAPDIPEDLYFLIKRAVSIRKHLEKFRKDTAAKYRLILVESRIHRLARYFKRSKQLPANWKYQAATASTLVA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRR0</accession>
    <name>Q5CRR0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F11M21.28-like 3 CCCH RNA binding domain protein involved in RNA metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_1830</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626126.1">
        <property type="nucleotide sequence ID" value="XM_626126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRR0"/>
    <dbReference type="GeneID" id="3373277"/>
    <dbReference type="KEGG" id="cpv:cgd5_1830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1830"/>
    <dbReference type="InParanoid" id="Q5CRR0"/>
    <dbReference type="OrthoDB" id="20534at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045234">
        <property type="entry name" value="Unkempt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493:SF50">
        <property type="entry name" value="RING FINGER PROTEIN UNKEMPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493">
        <property type="entry name" value="UNKEMPT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="74"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="111"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="345" mass="40968" checksum="DF2AE6A917E15626" modified="2005-04-12" version="1">MNNAKTAFELNTRIETVNCISNQKSINCYLKDDPSVINISYKEPLSEKMDEIKAKSYRKEFSRSNILTKEQLNNFRTVLCNDHLNSNCLDPETCFYSHCTAWQRRNPTKYKYSSNICPDIEFSRKGTKGRMSLNCRCKKGKFCEFAHTKEEELYHPDAYKTKKCNTFPNCKRFYCPFIHDSETNLINFNEKNLKEKISDDMIPITSKNEKSDEKRIVNIFSPYSQDKFKRNREINFGELKHELLIKLVNCQKLVLEEKYSSAQNLAEDFTSMITYLCRSCFLPEIFSTNSKLNNFQHEFLYPENITNQLNNNHMKDVFNFSFDFKHFLKDEELKRNYLLEDLFTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRW0</accession>
    <name>Q5CRW0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Translocation protein SEC62</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd5_1270</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC62 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88119.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626076.1">
        <property type="nucleotide sequence ID" value="XM_626076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRW0"/>
    <dbReference type="FunCoup" id="Q5CRW0">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRW0"/>
    <dbReference type="GeneID" id="3373061"/>
    <dbReference type="KEGG" id="cpv:cgd5_1270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1270"/>
    <dbReference type="InParanoid" id="Q5CRW0"/>
    <dbReference type="OMA" id="QYKPIKG"/>
    <dbReference type="OrthoDB" id="200187at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031204">
        <property type="term" value="P:post-translational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004728">
        <property type="entry name" value="Sec62"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12443:SF9">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03839">
        <property type="entry name" value="Sec62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0811">Translocation</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="169"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88119.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="375" mass="43315" checksum="6612BE6C8E2DB19B" modified="2005-04-12" version="1">MKMAEQVDQELMYTKFVRFLLGSKTGVRTKGAIEVGRRAVDYFRGIEFIRWMRKNEDHIKESYPEVVKNISFESINDLNQVGTELIRRSFIVRAEYKPVGTNTGDLKIPKWPKRLCVTSNQNFDEHSFYIITFDSNKTMSNILMISILVSVVALFMFPAWPLAIKISVWYISVVFLSAMLIVFFGRLIVFAFLWFFGFDFWILPNLFDEDTGVIDSFKPLYSIIRRGDDWFMLSIRVFCAIFLAGAIYQLSKTHTASDVGQFARQSFLDVLDWGHRKISPPEDFTPTLHNSNMGSNEHIGERNLSNEEHICITRCLRFESKDAILDECATDCHCLSELLSLPCLKSRSICPSEFEEELNNAMAKNCQSNQEKNEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRW4</accession>
    <name>Q5CRW4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_1230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626072.1">
        <property type="nucleotide sequence ID" value="XM_626072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRW4"/>
    <dbReference type="GeneID" id="3373064"/>
    <dbReference type="KEGG" id="cpv:cgd5_1230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1230"/>
    <dbReference type="InParanoid" id="Q5CRW4"/>
    <dbReference type="OMA" id="WPNNENG"/>
    <dbReference type="OrthoDB" id="341767at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="250" mass="28254" checksum="4F44A2FC6FEAC72C" modified="2005-04-12" version="1">MRRLQSFKTPSRLNEKLKFSNKSNSINDATINNSTKFVPNISAFDSNEVLNNSAQTNDISLRNIKFDEKSELEEVERTNSLQSFDLPSIKAIKRFEALNKSGKQILIYDQSNNISVEPTIDNRTVGVCNHISESGIENVHNKLEGWSVFQLPKYMPESKKNYCEISKNSTPTLLHDTPSGSIGKLIFRQDGNIDLYLNSSKDKECTSFKIDCISKDNSEQFIAAFSKINELINLGKCDSLLIATPKIQKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRX6</accession>
    <name>Q5CRX6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_1090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626060.1">
        <property type="nucleotide sequence ID" value="XM_626060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRX6"/>
    <dbReference type="GeneID" id="3373073"/>
    <dbReference type="KEGG" id="cpv:cgd5_1090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1090"/>
    <dbReference type="InParanoid" id="Q5CRX6"/>
    <dbReference type="OrthoDB" id="342814at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="371" mass="43074" checksum="AD70B0CEA01E332A" modified="2005-04-12" version="1">MAILFLSSFSSCKSNEIDHKKGNISNLIFPFLKIYKKSFLNIVNINDLRNSKSVLNVYCENKNNDIYFIIKLLKYVYIKEKNIHKKKWISNQLKKIMFYKEYNNESSSSLQSKIFNERSEIAENHLLNWRFDIMPMHKVIIPKRNSISRNHLAFPITQERKFVPFNSRLGINQLYLPKLCSNGFLKDIIKINDIKNDCRNNYCVWNPGKLLLSKSSKILAQKTITNNLIFMKPIITGIKREDYIGSKKAFSINLTNSEIPIIPTIPSSNPTNYKSRVAFSAQKKSRSIPIQIKKAANIFPEDSVGNTEWNKYSDGRNRIRSGNAKETNAKYPQYDINCQNEGIFGKDIRERVRLKGPLGYKRLIGNKVQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRY0</accession>
    <name>Q5CRY0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626056.1">
        <property type="nucleotide sequence ID" value="XM_626056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRY0"/>
    <dbReference type="GeneID" id="3373298"/>
    <dbReference type="KEGG" id="cpv:cgd5_1050"/>
    <dbReference type="InParanoid" id="Q5CRY0"/>
    <dbReference type="OMA" id="EVINSPW"/>
    <dbReference type="OrthoDB" id="341338at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="410" mass="47861" checksum="9C032DA1B3943C2C" modified="2005-04-12" version="1" fragment="single">NILVSDSFNFFKELEKRFELLENENKEKDKNIDKISREKTDVEEKLSDFMKNNQDLKKERDQMKRELKIYEPLSRSKEMVDKMAAYLETLLIKRNEVITEITEDLSKNTGDLTEEISNIRKDIVGIENSIQKFSSIISHFKNDIIANENRRIQDSYMLVNSLKTQLTNSKEKIINLKRLLFNSVGRPGNALEPSLTFEVRNGSILHKLQGSHGNTLKCYCRIVGTTFEYTTSSNVVKTIPLEKVIGIDYGNNSNSFRRINQPKGFFHELFKRQTKSEAEEDKNEVINSPWLFFSIRILDGYDTFCSDFIASSLESAMSWVVTIGRYATYIQRSVGLFTYNFIQTKQEFYSVSLRMKVMHLCRQKELNISQLYIIAIHTSCLKNPQLIRNQAAWNNLKNIMRRITNKKFPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS36</accession>
    <name>Q5CS36_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626000.1">
        <property type="nucleotide sequence ID" value="XM_626000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS36"/>
    <dbReference type="GeneID" id="3373182"/>
    <dbReference type="KEGG" id="cpv:cgd5_380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_380"/>
    <dbReference type="InParanoid" id="Q5CS36"/>
    <dbReference type="OMA" id="YKYLCIV"/>
    <dbReference type="OrthoDB" id="339566at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="161"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="204" mass="22902" checksum="5202DC23CCC3A5BC" modified="2005-04-12" version="1">MDVSEANHYNNSNKYEPQIMNNASSTSSSSSLKELCGLLLSSFCGILDDFGLETQADEQMLLIAIETGDFDSVIEYVKLFRNKISSILLLNNISRDFRTDIDIIKDVDNLQDGVYEQIGDIKRNSLNNNSINIDVNEFEQKIDLNNNQEFVNLKLLSPNSITNNNNNNNNSNNIKKSPVPPLNVEKAGPGSWNRGQLPNEYPIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS37</accession>
    <name>Q5CS37_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625999.1">
        <property type="nucleotide sequence ID" value="XM_625999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS37"/>
    <dbReference type="GeneID" id="3373314"/>
    <dbReference type="KEGG" id="cpv:cgd5_370"/>
    <dbReference type="InParanoid" id="Q5CS37"/>
    <dbReference type="OMA" id="NHQRICK"/>
    <dbReference type="OrthoDB" id="342322at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="433" mass="50504" checksum="318DF82B07D5A3DA" modified="2005-04-12" version="1" fragment="single">IISNMPILKNELQKDRDKDEEKVEVLNKSISEKKEKLNFLENNTRNGFNNSIKKIENILINAYNQANSNYNSFFYNINMLTLPYNNLSEEPSEVLQRLNIRNENISEQDNLRMKILQGVNTELNDSLRMTLDVVLKTYKELEKIQNKIEDLILENKELKNGTFNLNMSIQELKNENNKLSRENFYLNEQIKERVSTCDKYKSALNKSIKTMKKLYFENDKYNKEISQLENQLVVSKLRVAQHNEELEHIRTLLKYYKNQVKSDYILSPAIEQIIKVEPCRIPSNNKEISKNNNQNHHKNTNIGSILSKLLFNHSSSNTRNLHKNKSKKIPLISTSYNNNSPQSLSPFSKSHCNNKQENTKYNSSLTITTPVKFKKLYNDEHSIQSTGTDYCNNDLFFNHQRICKENLFSSDDEGFIENLLSSPPSIKSAKSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS41</accession>
    <name>Q5CS41_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625995.1">
        <property type="nucleotide sequence ID" value="XM_625995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS41"/>
    <dbReference type="GeneID" id="3373187"/>
    <dbReference type="KEGG" id="cpv:cgd5_330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_330"/>
    <dbReference type="InParanoid" id="Q5CS41"/>
    <dbReference type="OMA" id="INIHIID"/>
    <dbReference type="OrthoDB" id="341448at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1167" mass="137496" checksum="6BADD9BDE3680AEB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSA1</accession>
    <name>Q5CSA1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TPR repeat proteini</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_3540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628166.1">
        <property type="nucleotide sequence ID" value="XM_628166.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSA1"/>
    <dbReference type="GeneID" id="3371577"/>
    <dbReference type="KEGG" id="cpv:cgd1_3540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3540"/>
    <dbReference type="InParanoid" id="Q5CSA1"/>
    <dbReference type="OMA" id="INEYSIC"/>
    <dbReference type="OrthoDB" id="343875at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031101">
        <property type="entry name" value="Ctr9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14027:SF2">
        <property type="entry name" value="RNA POLYMERASE-ASSOCIATED PROTEIN CTR9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1236"/>
            <end position="1500"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="1175"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1236"/>
            <end position="1255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1256"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1268"/>
            <end position="1291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1299"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1329"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1367"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1380"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1406"/>
            <end position="1436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1448"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1462"/>
            <end position="1477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1478"/>
            <end position="1489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1500" mass="172710" checksum="704FCC4CCF994CDB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSH4</accession>
    <name>Q5CSH4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Methionine aminopeptidase</fullName>
            <ecNumber evidence="10">3.4.11.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd1_2700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 10">
            <text>Release of N-terminal amino acids, preferentially methionine, from peptides and arylamides.</text>
            <dbReference type="EC" id="3.4.11.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="10">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="10">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Co(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:48828"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <cofactor evidence="8">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="8">Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Associates with the 60S ribosomal subunit of the 80S translational complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8 9">Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.18" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628093.1">
        <property type="nucleotide sequence ID" value="XM_628093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSH4"/>
    <dbReference type="FunCoup" id="Q5CSH4">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSH4"/>
    <dbReference type="MEROPS" id="M24.017"/>
    <dbReference type="GeneID" id="3371686"/>
    <dbReference type="KEGG" id="cpv:cgd1_2700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2700"/>
    <dbReference type="InParanoid" id="Q5CSH4"/>
    <dbReference type="OMA" id="INQGTHQ"/>
    <dbReference type="OrthoDB" id="3209743at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004239">
        <property type="term" value="F:initiator methionyl aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01086">
        <property type="entry name" value="MetAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01974">
        <property type="entry name" value="MetAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001714">
        <property type="entry name" value="Pept_M24_MAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002467">
        <property type="entry name" value="Pept_M24A_MAP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031615">
        <property type="entry name" value="Zfn-C6H2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00500">
        <property type="entry name" value="met_pdase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43330:SF7">
        <property type="entry name" value="METHIONINE AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15801">
        <property type="entry name" value="zf-C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00599">
        <property type="entry name" value="MAPEPTIDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00680">
        <property type="entry name" value="MAP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52013">
        <property type="entry name" value="ZF_C6H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8 10" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 8 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C6H2-type" evidence="11">
        <location>
            <begin position="13"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="239"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="313"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>a protein</name>
            <dbReference type="ChEBI" id="CHEBI:16541"/>
        </ligand>
        <ligandPart>
            <name>N-terminal L-methionine residue</name>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
        </ligandPart>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="346"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="377"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>4</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="407" mass="45437" checksum="F46BDA2E5D078FA1" modified="2005-04-12" version="1">MTDNTDELNDSKIFSCEGCGSNTKSKLSCPQCKKLGLKTSFFCSQVCFKENWAIHKLKHQLGGSNKEVAKVSLDLVKKNVILDDPRTWVNCSHISKFIGFNGFTGPLRPYPISIKRKVPSHILRPDYADDKEGRPFSELKRKKSSAIVTATAEEIELLRECCKIGREALDIAASMIKPGVTTDAIDEAVHNFIISKNSYPSPLNYWEFPKSCCTSVNEIICHGIPDFRPLEEGDIVNVDISVYYKGVHSDLNETFPVGKVDEKSMKLMKVAYQCLEESIKICKPGTMYREIGNLIQSICDKQGFSVVKTYCGHGVGALFHCAPNVPHYKNNKAVGTMKPGHVFTIEPMINAGRFEDITWPDDWTSATLDGSRSAQFEHTLLITETGVEVLTKRLESSPKLEILSEIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSH5</accession>
    <name>Q5CSH5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">HUSSY-3 like methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd1_2680</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628092.1">
        <property type="nucleotide sequence ID" value="XM_628092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSH5"/>
    <dbReference type="FunCoup" id="Q5CSH5">
        <property type="interactions" value="470"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSH5"/>
    <dbReference type="GeneID" id="3371483"/>
    <dbReference type="KEGG" id="cpv:cgd1_2680"/>
    <dbReference type="InParanoid" id="Q5CSH5"/>
    <dbReference type="OMA" id="WIQEKKE"/>
    <dbReference type="OrthoDB" id="2877at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070476">
        <property type="term" value="P:rRNA (guanine-N7)-methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000017">
        <property type="entry name" value="probable 18S rRNA (Guanine-N(7))-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039769">
        <property type="entry name" value="Bud23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022238">
        <property type="entry name" value="Bud23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041698">
        <property type="entry name" value="Methyltransf_25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734:SF0">
        <property type="entry name" value="18S RRNA (GUANINE-N(7))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12734">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13649">
        <property type="entry name" value="Methyltransf_25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12589">
        <property type="entry name" value="WBS_methylT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="11">
        <location>
            <begin position="54"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="18S rRNA (guanine(1575)-N(7))-methyltransferase Bud23 C-terminal" evidence="10">
        <location>
            <begin position="205"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="221"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="240"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF12589"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="290" mass="32721" checksum="39AD6011522F4D19" modified="2005-04-12" version="1" fragment="single">KIMTRPETQAPPELYYNESEAIKYSKSSRIIDIQTKLTERAIELLLLPQHPCLILDIGCGTGISGSVLEDHNHVWVGIDISVGMLNVLDIYDDDSESTGDALLADMGELLRFRPGVFDGAISISVLQWLCNADRKSHDPYKRLLVFFKWLFNSLNRGSRAVFQFYPDSPSQVEMITSAALKSGFGGGLVVDFPNSSKAKKYYLCLWAGFYSTIPQTLPQGLTDENDEEMTSASNLGRSGCKLKTKKRGNKREHRVKSREWILEKKNVQRLKGFEVRPDSKYTGRKRKSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSJ7</accession>
    <name>Q5CSJ7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA repair protein RAD50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">cgd1_2410</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SMC family. RAD50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628070.1">
        <property type="nucleotide sequence ID" value="XM_628070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSJ7"/>
    <dbReference type="FunCoup" id="Q5CSJ7">
        <property type="interactions" value="72"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSJ7"/>
    <dbReference type="GeneID" id="3371485"/>
    <dbReference type="KEGG" id="cpv:cgd1_2410"/>
    <dbReference type="InParanoid" id="Q5CSJ7"/>
    <dbReference type="OMA" id="FSDYYYR"/>
    <dbReference type="OrthoDB" id="18797at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030870">
        <property type="term" value="C:Mre11 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003691">
        <property type="term" value="F:double-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051880">
        <property type="term" value="F:G-quadruplex DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043047">
        <property type="term" value="F:single-stranded telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000593">
        <property type="entry name" value="DNA repair protein RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18867">
        <property type="entry name" value="RAD50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0158">Chromosome</keyword>
    <keyword evidence="14 19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0227">DNA damage</keyword>
    <keyword evidence="15" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="17" id="KW-0469">Meiosis</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="20">
        <location>
            <begin position="17"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="308"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="639"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1062"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EAK88600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1062" mass="123625" checksum="372178F11947C00E" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSQ2</accession>
    <name>Q5CSQ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane associated protein with 10 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628015.1">
        <property type="nucleotide sequence ID" value="XM_628015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSQ2"/>
    <dbReference type="GeneID" id="3371632"/>
    <dbReference type="KEGG" id="cpv:cgd1_1750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1750"/>
    <dbReference type="InParanoid" id="Q5CSQ2"/>
    <dbReference type="OMA" id="WCTESIT"/>
    <dbReference type="OrthoDB" id="342773at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="358"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="404"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="472"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="512" mass="59577" checksum="8CF40F5865E2A70C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSV1</accession>
    <name>Q5CSV1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd1_1220</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627966.1">
        <property type="nucleotide sequence ID" value="XM_627966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSV1"/>
    <dbReference type="STRING" id="353152.Q5CSV1"/>
    <dbReference type="GeneID" id="3371600"/>
    <dbReference type="KEGG" id="cpv:cgd1_1220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1220"/>
    <dbReference type="InParanoid" id="Q5CSV1"/>
    <dbReference type="OMA" id="FLATINW"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05573">
        <property type="entry name" value="STKc_ROCK_NDR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000024">
        <property type="entry name" value="Probable serine/threonine-protein kinase cot-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE GREATWALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00133">
        <property type="entry name" value="S_TK_X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="148"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="13">
        <location>
            <begin position="466"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="713"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="23"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK88466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="758" mass="85779" checksum="48996C9023F1E72F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSY2</accession>
    <name>Q5CSY2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627935.1">
        <property type="nucleotide sequence ID" value="XM_627935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSY2"/>
    <dbReference type="SMR" id="Q5CSY2"/>
    <dbReference type="STRING" id="353152.Q5CSY2"/>
    <dbReference type="GeneID" id="3371564"/>
    <dbReference type="KEGG" id="cpv:cgd1_870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_870"/>
    <dbReference type="InParanoid" id="Q5CSY2"/>
    <dbReference type="OMA" id="FLVQPRC"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF504">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5006528974" description="Peptidyl-prolyl cis-trans isomerase" evidence="4">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="42"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="210" mass="22871" checksum="6518910791F49E0E" modified="2005-04-12" version="1">MRFIFAFISLLLGLIVSVFAEKGVRPSTVTPSVVVELTVSIDKEESKLRIGLFGVEVPKTANNFYSLCVGGMKDKDGKEMSYIGSIFHRVIPGFMAQGGDFTNGNGTGGKSIYGDSFEDENFKFVHESHVVSMANRGPNTNGSQFFITFTPTPHLDGRHVVFGKLVDDESKLTLTKIEQLGSYSGRTSKRIEVTACSHYSGTAPSAKLEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSZ2</accession>
    <name>Q5CSZ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dual specificity phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627925.1">
        <property type="nucleotide sequence ID" value="XM_627925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSZ2"/>
    <dbReference type="STRING" id="353152.Q5CSZ2"/>
    <dbReference type="GeneID" id="3371373"/>
    <dbReference type="KEGG" id="cpv:cgd1_760"/>
    <dbReference type="InParanoid" id="Q5CSZ2"/>
    <dbReference type="OMA" id="ASECITN"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46381:SF2">
        <property type="entry name" value="MAP KINASE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46381">
        <property type="entry name" value="MKPA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="4">
        <location>
            <begin position="29"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="5">
        <location>
            <begin position="96"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="439"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="640"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="640"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="792" mass="91282" checksum="4D1630CE3A3F9AF0" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT03</accession>
    <name>Q5CT03_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">U3 small nucleolar RNA-associated protein 11</fullName>
            <shortName evidence="5">U3 snoRNA-associated protein 11</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_610</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the UTP11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627914.1">
        <property type="nucleotide sequence ID" value="XM_627914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT03"/>
    <dbReference type="STRING" id="353152.Q5CT03"/>
    <dbReference type="GeneID" id="3371527"/>
    <dbReference type="KEGG" id="cpv:cgd1_610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_610"/>
    <dbReference type="InParanoid" id="Q5CT03"/>
    <dbReference type="OMA" id="DLKYVVM"/>
    <dbReference type="OrthoDB" id="29058at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007144">
        <property type="entry name" value="SSU_processome_Utp11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12838:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03998">
        <property type="entry name" value="Utp11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015952">
        <property type="entry name" value="U3snoRNP11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="235" mass="27748" checksum="4340C6CD6136C7E4" modified="2005-04-12" version="1">MSSLKHSIHRRVHLERATPVNRLRFGILERKKDYKIRAKRYHEKENLLKSLSEKARTRNPDEFDFGMVNSRLENGRYKKIGSDLQNGGLTSAEERKLAESQNLTYVHFRKSIDNKKIERMEKELTLFGQNMQRSHIFFDDEHEQLESGSQKNKSNSKKLKDLDSLSNLETIPKEVVKNITKSYKIFNDTIARSQKLEKVSKHLELQRDLKSKGKKKKVVTKNGNTEYVWYPKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT56</accession>
    <name>Q5CT56_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_4360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626613.1">
        <property type="nucleotide sequence ID" value="XM_626613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT56"/>
    <dbReference type="GeneID" id="3373707"/>
    <dbReference type="KEGG" id="cpv:cgd2_4360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4360"/>
    <dbReference type="InParanoid" id="Q5CT56"/>
    <dbReference type="OrthoDB" id="337278at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="333" mass="37914" checksum="D9F41C692F375B94" modified="2005-04-12" version="1">MQYKEFSFSSRESIKIENDQPSLSLNSAEKNVIDSLPILNRHGFGPLTIVATSLNNKFQKRVYSGTFEIPIYGRDSHLVFYEIESKNFILISIEKHFVGDLIGNSGTVFIESGSDVFCLNELELRKSNGDIISTECPWGAQIFLESEIINFKFSPESIRRFKPQEPPADWNPITSTIFPSNRNYVELIKLLKSNISKSSEAAFSNIQEDGTPTALLFIVDNKYMSLFLPENFSYSYEKRSCTIFRSDGSYYDVQKGIFRTDNGLKIITNAPWGKKLAFDESLVSISNNINKELNSFIIPSIVVGTYGDFSEKKSQRSISKKIKNVYQRLKRVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT99</accession>
    <name>Q5CT99_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">BBOX Zn finger domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_3860</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626570.1">
        <property type="nucleotide sequence ID" value="XM_626570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT99"/>
    <dbReference type="GeneID" id="3373406"/>
    <dbReference type="KEGG" id="cpv:cgd2_3860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3860"/>
    <dbReference type="InParanoid" id="Q5CT99"/>
    <dbReference type="OMA" id="FRDSEEW"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19821">
        <property type="entry name" value="Bbox1_BBX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.228.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049808">
        <property type="entry name" value="CONSTANS-like_Bbox1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31717">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31717:SF45">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="266"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="313"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="524" mass="60415" checksum="EA3CFE299C00A2AF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTA7</accession>
    <name>Q5CTA7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_3770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626562.1">
        <property type="nucleotide sequence ID" value="XM_626562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTA7"/>
    <dbReference type="GeneID" id="3373410"/>
    <dbReference type="KEGG" id="cpv:cgd2_3770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3770"/>
    <dbReference type="InParanoid" id="Q5CTA7"/>
    <dbReference type="OMA" id="EYLIICE"/>
    <dbReference type="OrthoDB" id="342168at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="276"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="218"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="376" mass="43048" checksum="78D608AF2E3F2602" modified="2005-04-12" version="1">MEILNQVDMSVVTTTASNSEFVDYSASNNAKTSRGEDNDLSNYLESNKENLTLDETNINDSDNLLFEKDFLSDNNRESFSEYNGSDTEMEGCEELVMMVPDLDSTLKFKHDTERFFMTLSIAEAELDLAKSASRTSKLAMGDDFDISSRGGTNCLKEIRNYVEELLDTVNDVRDSNFGIQRIVEECNEILQQSVSQSNLSQIDTMDMNTITDQNLVSIERLKLLCEAISEENSRLKKEIDILNNENEFLIHKVDHEEESSLQEEKRPYNYFRNNPIMRLFFFIFVLAMFSPANISNGFQKAQVFEQQSGFSEIAPEFPDRDYKFSKINTLQLLEKSLKGLKFEDISSQGHPDTISICSILSELDVLEKCFTRIRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTA9</accession>
    <name>Q5CTA9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626560.1">
        <property type="nucleotide sequence ID" value="XM_626560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTA9"/>
    <dbReference type="GeneID" id="3373615"/>
    <dbReference type="KEGG" id="cpv:cgd2_3750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3750"/>
    <dbReference type="InParanoid" id="Q5CTA9"/>
    <dbReference type="OrthoDB" id="341880at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="745" mass="84446" checksum="4269DFD8F95A06F9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTB4</accession>
    <name>Q5CTB4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SWI/SNF related putative transcriptional regulator ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd2_3700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626555.1">
        <property type="nucleotide sequence ID" value="XM_626555.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTB4"/>
    <dbReference type="GeneID" id="3373613"/>
    <dbReference type="KEGG" id="cpv:cgd2_3700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3700"/>
    <dbReference type="InParanoid" id="Q5CTB4"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="590"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="894"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1138"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1332"/>
            <end position="1375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1408"/>
            <end position="1552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="1153"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1168"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1338"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1349"/>
            <end position="1369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="1420"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1489"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1499"/>
            <end position="1511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1512"/>
            <end position="1525"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1532"/>
            <end position="1543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1552" mass="180004" checksum="C1B1175F0847C740" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTB5</accession>
    <name>Q5CTB5_CRYPI</name>
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        <submittedName>
            <fullName evidence="2">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626554.1">
        <property type="nucleotide sequence ID" value="XM_626554.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTB5"/>
    <dbReference type="GeneID" id="3373612"/>
    <dbReference type="KEGG" id="cpv:cgd2_3690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3690"/>
    <dbReference type="InParanoid" id="Q5CTB5"/>
    <dbReference type="OMA" id="FLQCQIY"/>
    <dbReference type="OrthoDB" id="340983at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028103">
        <property type="entry name" value="Spatacsin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13650:SF0">
        <property type="entry name" value="SPATACSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1697"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3054"/>
            <end position="3073"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1707"/>
            <end position="1717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1718"/>
            <end position="1759"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1760"/>
            <end position="1770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3058"/>
            <end position="3073"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="3948" mass="462994" checksum="CA24E16AAD6AF0AD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTB6</accession>
    <name>Q5CTB6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_3670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626553.1">
        <property type="nucleotide sequence ID" value="XM_626553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTB6"/>
    <dbReference type="GeneID" id="3373611"/>
    <dbReference type="KEGG" id="cpv:cgd2_3670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3670"/>
    <dbReference type="InParanoid" id="Q5CTB6"/>
    <dbReference type="OMA" id="CKRSTNI"/>
    <dbReference type="OrthoDB" id="338495at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005815">
        <property type="term" value="C:microtubule organizing center"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010564">
        <property type="term" value="P:regulation of cell cycle process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039893">
        <property type="entry name" value="CEP120-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21574:SF0">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 120 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="200"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="260"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="489"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="292"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="694" mass="80485" checksum="C409E94A7BA5F9D2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTG9</accession>
    <name>Q5CTG9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_3060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626500.1">
        <property type="nucleotide sequence ID" value="XM_626500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTG9"/>
    <dbReference type="GeneID" id="3373568"/>
    <dbReference type="KEGG" id="cpv:cgd2_3060"/>
    <dbReference type="InParanoid" id="Q5CTG9"/>
    <dbReference type="OrthoDB" id="339813at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="158" mass="18029" checksum="CE9EA3FDB59F6E35" modified="2005-04-12" version="1">MGNKSEFIAFNSECSQILKKSDSDDVNSWKNHENFEYCKEMNFTDRKLQIKSGFGSHIRLPQSTSSLRGPQDTPQGNIFKYQTQKICVSVLSLHYIKVCEKLCDAETALTVEEEVFPRSCFPICVDFANHVCIRGCSFFGCNIPFDACSYQMCNFKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTM7</accession>
    <name>Q5CTM7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626442.1">
        <property type="nucleotide sequence ID" value="XM_626442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTM7"/>
    <dbReference type="GeneID" id="3373505"/>
    <dbReference type="KEGG" id="cpv:cgd2_2380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2380"/>
    <dbReference type="InParanoid" id="Q5CTM7"/>
    <dbReference type="OrthoDB" id="341793at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="321" mass="37368" checksum="6BB2FB18F50C0548" modified="2005-04-12" version="1">MNTESSSFEWLDVISRQGSKLSRTSFNTAKTDLSIYYECDELEEYIEDKIELPRDKSEDYFDFKKSVTTKFTEVVPRSKTRSTYISDAYYGFSNNRDKNKEHERIRSKTIPYKNNISGIISSALFSDVFLIENSEDVFIDNSNLASKKFNTKIKIIKEGNSFQSINSQDSFVNYLNDNTPSTHCTESQVKENLIRRSEDTNKNHEKKQDSFQKSCNLENNQLFESFEVKLNSKRSIFETRQSYNATNRNLFNSNPQLIEGKSRTVESKTSIEKNKDFNNKLYIDLPTIFVEGETDINRKVSQFDCILSTFFKCKNICCLVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTR9</accession>
    <name>Q5CTR9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TBC domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_1860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626400.1">
        <property type="nucleotide sequence ID" value="XM_626400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTR9"/>
    <dbReference type="STRING" id="353152.Q5CTR9"/>
    <dbReference type="GeneID" id="3373737"/>
    <dbReference type="KEGG" id="cpv:cgd2_1860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1860"/>
    <dbReference type="InParanoid" id="Q5CTR9"/>
    <dbReference type="OMA" id="RICDISY"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="747"/>
            <end position="1138"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1246" mass="144538" checksum="A101DC896E7FEDAE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTS9</accession>
    <name>Q5CTS9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_1710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626390.1">
        <property type="nucleotide sequence ID" value="XM_626390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTS9"/>
    <dbReference type="GeneID" id="3373746"/>
    <dbReference type="KEGG" id="cpv:cgd2_1710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1710"/>
    <dbReference type="InParanoid" id="Q5CTS9"/>
    <dbReference type="OMA" id="YSANSTH"/>
    <dbReference type="OrthoDB" id="341971at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1167" mass="135069" checksum="68317C95F1656722" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU27</accession>
    <name>Q5CU27_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Mannose-P-dolichol utilization defect 1 protein homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the MPDU1 (TC 2.A.43.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626292.1">
        <property type="nucleotide sequence ID" value="XM_626292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU27"/>
    <dbReference type="FunCoup" id="Q5CU27">
        <property type="interactions" value="271"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU27"/>
    <dbReference type="GeneID" id="3373657"/>
    <dbReference type="KEGG" id="cpv:cgd2_550"/>
    <dbReference type="InParanoid" id="Q5CU27"/>
    <dbReference type="OMA" id="LQVLYYW"/>
    <dbReference type="OrthoDB" id="271506at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.290">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016817">
        <property type="entry name" value="MannP-dilichol_defect-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006603">
        <property type="entry name" value="PQ-loop_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 LEC35 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12226:SF2">
        <property type="entry name" value="MANNOSE-P-DOLICHOL UTILIZATION DEFECT 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04193">
        <property type="entry name" value="PQ-loop"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023381">
        <property type="entry name" value="MannP-dilichol_defect-1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00679">
        <property type="entry name" value="CTNS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="17"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="58"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="116"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="11">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="27733" checksum="B649C0E6BDA05BB6" modified="2005-04-12" version="1" fragment="single">LIEFFSLRNKKMNALELISIDLFFQLISYLIIAGSCIVKIPQIIKILNSRSTQGISSFSIYVEILSSCIYSFSNWRFNVPWLLWADSAFIGIQNAFILILCVVYSQNKKKFPINQIFYITSISLLIAALYQDIIPVQVLRYLSISPLIFVVLSRVPQIVKCYIESSTGQLSFISFFLLTGGSWSRVATVLFSESKSNTILLLTNVISALLNTVPLMQIVIFKYCSSISEKNGIEQKRHSKRKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU38</accession>
    <name>Q5CU38_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_4340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626976.1">
        <property type="nucleotide sequence ID" value="XM_626976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU38"/>
    <dbReference type="GeneID" id="3374054"/>
    <dbReference type="KEGG" id="cpv:cgd3_4340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4340"/>
    <dbReference type="InParanoid" id="Q5CU38"/>
    <dbReference type="OrthoDB" id="340707at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="203" mass="23388" checksum="4A80AB71C407DB13" modified="2005-04-12" version="1">MTSKIIDNFDNTCLSTPRRSRNIEDETIALAPDARRAVRKQFNIEFINTREWCDELDNFKSENFFENMYEKHVSTPLSKVFSRSSLNTKHLITPKRGLNRDSILSTGTPRGKTSQYYLDLTYECVSICGNDSDPESSYEKDHSPIKNIDINENIKNVSMEKSEYYNSRILSLCKRSRDSLEFDAGSDSPTELVQIMSKSLRLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUC8</accession>
    <name>Q5CUC8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_3350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626886.1">
        <property type="nucleotide sequence ID" value="XM_626886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUC8"/>
    <dbReference type="GeneID" id="3374126"/>
    <dbReference type="KEGG" id="cpv:cgd3_3350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3350"/>
    <dbReference type="InParanoid" id="Q5CUC8"/>
    <dbReference type="OMA" id="NIMIIEV"/>
    <dbReference type="OrthoDB" id="339901at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="158"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="503" mass="55926" checksum="EB4EC06B89C93082" modified="2005-04-12" version="1">MIETTISEKTFSPSSSEIMRKATRLVDQLLIKTSNDFSNLEGVALKNNNISDSKLAITEDSINVDSNSITDSETFSALTSARKNIPSIDIIKRLAGRLKNKDSDTISEFNFPNKKTVSNGQDAGDYCLQKSENCRSKSASPTSSENREKNNCGLSHDFAQMNAKLSEINKRVESLSSNIEDIQDADILEDGGYAKVENKQEPGRFDDEGNTSRRIYERDTEDNYLSQLNVAVLQQERLRMWARDNAKYTSSISNTSENGNNQESEHIPFSDVYYTHQSLKYKNGELTSSNDALNSSVLSTTVSGTAGQFAHSNDTTVYEAKTNCRNTVSDFSRTVKVCAGGEYSENKDSEVGGASETISFERISGRFTEPKILRFIRVGNQLRRSITVTPLVEDLQRVLNGEAASLGFSFNDSDFDSRTQFNNKLEKLSNSNISPFNPSKSTSRLSNNMVIITIKDNGTGFKRSTRSRTMDDTISVDSAESYEKSFFSCRECSWNPTSACSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUJ6</accession>
    <name>Q5CUJ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_2570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626818.1">
        <property type="nucleotide sequence ID" value="XM_626818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUJ6"/>
    <dbReference type="STRING" id="353152.Q5CUJ6"/>
    <dbReference type="GeneID" id="3373904"/>
    <dbReference type="KEGG" id="cpv:cgd3_2570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2570"/>
    <dbReference type="InParanoid" id="Q5CUJ6"/>
    <dbReference type="OMA" id="PIRTYRI"/>
    <dbReference type="OrthoDB" id="194386at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614:SF130">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE EEF2KMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="379" mass="43328" checksum="5824D32010FD3535" modified="2005-04-12" version="1">MRYRKKKQKKMNRLKNAIFTLQSKKTVISICKHIGLFKDLALQVDLVKNILNCEILKKYPLPLIYQRNLICEIVKIIESAGDEVSDELYMHLSQLMGSCHSNLVSHIIITFPNNQTDICLNSSNLVNSGNFVFGFEECNLVGMRPWSAGYRLVEWLIHSVNLGRNVANSDLIELGSGIGISSIIPYSVLPIKSICSTDHDPKIINNLRYNFEINGILLNSEFEEHAKSNSNKKYARVMCLDWETININIAKEILKPLKNPIIISSDVIYDNDLTLLFVRTLRFFLSSCHEKKFGSYHKKCISKDPKNKSVKWDELQEADFGSMSTYAISVNTVRNQHTIQYFVDCCIENGLTISRDSKVIPMIFNIELDTPTVIFIISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUM5</accession>
    <name>Q5CUM5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Replication protein A1 large subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd3_2210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626789.1">
        <property type="nucleotide sequence ID" value="XM_626789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUM5"/>
    <dbReference type="FunCoup" id="Q5CUM5">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUM5"/>
    <dbReference type="GeneID" id="3373783"/>
    <dbReference type="KEGG" id="cpv:cgd3_2210"/>
    <dbReference type="InParanoid" id="Q5CUM5"/>
    <dbReference type="OMA" id="FNSYAML"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication protein A OB" evidence="10">
        <location>
            <begin position="135"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="9">
        <location>
            <begin position="323"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="484" mass="55339" checksum="04783844773DB814" modified="2005-04-12" version="1" fragment="single">FHLFKLSISCFMPIREVNVNRQTISIKGRIIQKSSLQILKSGLRFFHLDIIDKDNDVIRVKFWRQKAEEYHNILQHGSVYILKCTGNDVVVSNTKFNDTSNPYEINFSDRCFVRKVENDDDSIGKAPKYVFTTVKDIREIPVPSIVDLIGIVRHFSPSTKVISRKNNDEVSRRTISVVDKTGFLINITLWGELAEVSDEKFLGNPVVALKSIQIREYQGRQGSTLNGRSNMEFSIDDGKMEELRDWYDSIGSSIKFESISNISSNESPNNFRVNDKLYSGRTLKDIRNRMEDNEFSSTPSFQVIARISKIGSINVNQQVSGDKGGSLTYDACPICKKKVLFSTSYCEKCDESVVPETKFLFPVTIEDHTCSLTVQCFHEIGSTFIKELSASACKEMEQNNDKKLNFILNLQCMWRHYNLKIQLKAEEYNNQKKTRAIIQSAEPIDLNQISYLMLESISQSILGKTNKRSLFEDNINTNKRISVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUN3</accession>
    <name>Q5CUN3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626781.1">
        <property type="nucleotide sequence ID" value="XM_626781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUN3"/>
    <dbReference type="GeneID" id="3374042"/>
    <dbReference type="KEGG" id="cpv:cgd3_2130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2130"/>
    <dbReference type="InParanoid" id="Q5CUN3"/>
    <dbReference type="OMA" id="ELAMNTW"/>
    <dbReference type="OrthoDB" id="336283at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254527" evidence="1">
        <location>
            <begin position="26"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="324" mass="38125" checksum="C08C21EF9D1DB3FC" modified="2005-04-12" version="1">MNVRLNFLLYTAVLVFICLTSSCQSYESFDPRSPNGGVTLNGYIQKPGIFYFLNEELRWRDRDFPFYNMLMSTVATTFINLINQIEKNEEGLMLYYSREVARLAKKGEVINSIYKSFLTVKGSKHELKIYEEQFKPLCKSYRIEIAKSPIISIVSHSTSRLNAYDYLIPFIPSEVLDPVMKKFSIEVTKFLWPQSFAEMSNVFITMIEKLEKLCKKINFNLLESCNEYMQQSRSYLIDLIKNHEKFLKYSKTKNANYLEFSNILRKLRGEILSFKPYQIVLRKLDPVKADALGVPMFSGFNHSILDETMKEYYEILRDRRLKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUS9</accession>
    <name>Q5CUS9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_1620</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic/archaeal RNase P protein component 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626735.1">
        <property type="nucleotide sequence ID" value="XM_626735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUS9"/>
    <dbReference type="STRING" id="353152.Q5CUS9"/>
    <dbReference type="GeneID" id="3374020"/>
    <dbReference type="KEGG" id="cpv:cgd3_1620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1620"/>
    <dbReference type="InParanoid" id="Q5CUS9"/>
    <dbReference type="OMA" id="SCHNINI"/>
    <dbReference type="OrthoDB" id="17948at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016195">
        <property type="entry name" value="Pol/histidinol_Pase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002738">
        <property type="entry name" value="RNase_P_p30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13031">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01876">
        <property type="entry name" value="RNase_P_p30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89550">
        <property type="entry name" value="PHP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="345" mass="38810" checksum="DF284CA97D4CE75C" modified="2005-04-12" version="1">MSFELCVNWPGDLNKAKELILKAYSFGYLGIAFNNTLNLVEKCNKLRSSPNKNSVSGNILSILAKEGHVCPIQYIQLEKEELRGMRKRSLIVKSNSGPLVPKNAYLPLSLSCHNFEINKQFGKEDDTSFDFLQLRRLSIVFDNPDCVPYINALSRGPCNESSDSWSKAIFSSVPNQPYDLVSVRPTTQNALNSAISSVECDIISIDISSAPRLPFIIKRPQINLAISRGIFFELDISQCILNKGNSRRNFFSNLNTLTRHVPHKNIIITCNPSFPLDIKTPMDLSNICHVLLSLDFDRKVKVNSFDFINNNAIKALAKGTNRRSFASVILINKKEEHPDQEMDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV28</accession>
    <name>Q5CV28_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative fucose translocatorw ith 8 transmembrane domains, within locus of 3 paralogous genes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626636.1">
        <property type="nucleotide sequence ID" value="XM_626636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV28"/>
    <dbReference type="SMR" id="Q5CV28"/>
    <dbReference type="GeneID" id="3373799"/>
    <dbReference type="KEGG" id="cpv:cgd3_510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_510"/>
    <dbReference type="InParanoid" id="Q5CV28"/>
    <dbReference type="OMA" id="LCITTNI"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="214"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="245"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="36"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="341"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="341"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="366"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="380"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="389" mass="42518" checksum="CACBDC0559B7C552" modified="2005-04-12" version="1">MAGDFGNKSNSQEEVRYCFGLPNAVAAPIAMCAFIVSSIGCVYYNKKCYQKDLPFPVFMSWAQQLIGMAIMSTFLTIRGILSGNEEMSASIPLSKRLYRYKYAVFVAFCFCMNISLNNMCLKDAKVSMYAVAKSTTVCYSLLLQYFLLGIRAKLSSVLSCFVIIGGVIVGISDKEFGLEPRSFFMGTLSSFFQSLYSVAVKYTVPHCDNSTTELLLHVQELSCIILLVLSVAWGETSKVLSSNVFAFVSAPLSALWLWVLMAGSAILAICLNQCTYLVVSLTTPATYNVTGLVKQALQTAGGFIFWGDKLKPAPVGGACLTLTGSAIYTLTKLWDNTPKNTKQEETIKEQARLSVGTGSDAFENPLTENGNQNEKQPLIPEDKCEKGQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV58</accession>
    <name>Q5CV58_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_5330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627411.1">
        <property type="nucleotide sequence ID" value="XM_627411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV58"/>
    <dbReference type="GeneID" id="3374213"/>
    <dbReference type="KEGG" id="cpv:cgd8_5330"/>
    <dbReference type="InParanoid" id="Q5CV58"/>
    <dbReference type="OrthoDB" id="343384at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="25"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="323" mass="36193" checksum="F72D6FDBC9BCFC94" modified="2005-04-12" version="1">MAVVARKSVKLSPKNPTKVKSTGTNKKKLQVSRGRSKTRVNSEIKHHSGSPHPTRCLRGVSTRATFKRSPSPRKDWPFDEAILYPPHPRIGSPVTKVRARSSNPFLSNPKSKKNVKMNSCSAKPIASQSPALKKYNHHSGSPTHHLHPTRCLRGVSTRATFKRSPSPRKDWAFDEAILYPLHPRTGLPKSPKIKTRTLSNTKKAMDSEKEQKKTPIRAVRSASNKSISPSKSKKSPIKSISKKVGPILKKNCKEKVIHHTANQLNRDNKVCKFDIKTESIATVLDGEEEYIQSPVTSMHVGWGGNLLNYYYWNNKIAGIVRNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVI9</accession>
    <name>Q5CVI9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted alpha beta hydrolase family protein, signal peptide, duplicated adjacent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627280.1">
        <property type="nucleotide sequence ID" value="XM_627280.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVI9"/>
    <dbReference type="GeneID" id="3374256"/>
    <dbReference type="KEGG" id="cpv:cgd8_3880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3880"/>
    <dbReference type="InParanoid" id="Q5CVI9"/>
    <dbReference type="OMA" id="ERCMEIK"/>
    <dbReference type="OrthoDB" id="338410at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254994" evidence="1">
        <location>
            <begin position="28"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="613" mass="70894" checksum="865281DEB10862BE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVS1</accession>
    <name>Q5CVS1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SYG1/ ERD1 like integral membrane protein required for retention of ER lumen proteins, with 8-10 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_3000</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SYG1 (TC 2.A.94) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627198.1">
        <property type="nucleotide sequence ID" value="XM_627198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVS1"/>
    <dbReference type="FunCoup" id="Q5CVS1">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVS1"/>
    <dbReference type="GeneID" id="3374313"/>
    <dbReference type="KEGG" id="cpv:cgd8_3000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3000"/>
    <dbReference type="InParanoid" id="Q5CVS1"/>
    <dbReference type="OMA" id="WCQNYLE"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004342">
        <property type="entry name" value="EXS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783:SF46">
        <property type="entry name" value="PROTEIN ERD1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10783">
        <property type="entry name" value="XENOTROPIC AND POLYTROPIC RETROVIRUS RECEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03124">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51380">
        <property type="entry name" value="EXS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="347"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="391"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="599"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="1"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="EXS" evidence="7">
        <location>
            <begin position="485"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="681" mass="78861" checksum="B816FA5B3FC2D591" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVU1</accession>
    <name>Q5CVU1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_2780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627178.1">
        <property type="nucleotide sequence ID" value="XM_627178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVU1"/>
    <dbReference type="FunCoup" id="Q5CVU1">
        <property type="interactions" value="194"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVU1"/>
    <dbReference type="GeneID" id="3374198"/>
    <dbReference type="KEGG" id="cpv:cgd8_2780"/>
    <dbReference type="InParanoid" id="Q5CVU1"/>
    <dbReference type="OMA" id="KDMDPRW"/>
    <dbReference type="OrthoDB" id="6745403at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008568">
        <property type="entry name" value="EMC3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13116:SF5">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="182"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="231" mass="26272" checksum="918C6D6890137800" modified="2005-04-12" version="1" fragment="single">VQVMYLDKKILYWCTIPVTILVFCGVILRTILQTSSQKKKKKRLPFKNEKNLNDCLMSTQRVSLRNQEFQNHLNRSALIRSRRFLIPEDSFLKRKLFYCELESGYFHNSPESPSPLAALSNPDHSALTDMMKNQFGFLILNGGMGYLVNTLFSGFLVVYIPFPLSYSFKGMLQRGIESNPNISASFLSALSFYFIALLCCGEVVHLFLSIIGFEGVSGPQIDLPMMNQQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVV3</accession>
    <name>Q5CVV3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627166.1">
        <property type="nucleotide sequence ID" value="XM_627166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVV3"/>
    <dbReference type="GeneID" id="3374382"/>
    <dbReference type="KEGG" id="cpv:cgd8_2660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2660"/>
    <dbReference type="InParanoid" id="Q5CVV3"/>
    <dbReference type="OMA" id="ICTETIG"/>
    <dbReference type="OrthoDB" id="340131at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="428" mass="49662" checksum="516B199481F26579" modified="2005-04-12" version="1">MRQYSPIDIALDDDLFYSFRISMGIFDSLISKDEEEKVKRIFQNKKSLKVNDIDLYRQGFLKKIDLGENDLTSEVFTETNNFLSCIGKLDDEFIHLLFQFSEIIILDNSSSKLVLAVNESISYNSGIDESCECKVLPINSSIFGFVDYIDTRNDTIKSFISKFNKKMFDSSPFLDNKHKHNKNEFITYIKLLLRVSFIKSICLLKMYGKKLPIYLFDGSQLLIKIEPIFNSLNENCMISYKVIDGQIDSSIVKVDLDYYQFKWFHSWKKMLRNSSGYLFPHKNSMSQFLPNKKLCLQNTNNFEHTLTPLRKSLSNLNYEDSNFSPNNEKPSKKTSKSNQVHTQNKDIDTEEENDSSLKTNDESNPNSPSLSKTTNDVINELLNKPNPNIQSSKQKKKRSKQSESSDIENSQDYVDKLIQQQTMQLFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVV6</accession>
    <name>Q5CVV6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">APG10/ Aut1p like like autophagocytosis protein involved in vacuolar transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_2630</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATG3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627163.1">
        <property type="nucleotide sequence ID" value="XM_627163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVV6"/>
    <dbReference type="FunCoup" id="Q5CVV6">
        <property type="interactions" value="478"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVV6"/>
    <dbReference type="GeneID" id="3374579"/>
    <dbReference type="KEGG" id="cpv:cgd8_2630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2630"/>
    <dbReference type="InParanoid" id="Q5CVV6"/>
    <dbReference type="OMA" id="KWCKAIS"/>
    <dbReference type="OrthoDB" id="1584384at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019776">
        <property type="term" value="F:Atg8-family ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061723">
        <property type="term" value="P:glycophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044804">
        <property type="term" value="P:nucleophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007135">
        <property type="entry name" value="Atg3/Atg10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12866:SF2">
        <property type="entry name" value="UBIQUITIN-LIKE-CONJUGATING ENZYME ATG3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03987">
        <property type="entry name" value="Autophagy_act_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="242" mass="28004" checksum="40C5350296102EBA" modified="2005-04-12" version="1">MQSITHRLADQFRSVVGNFIPIDCSNSKFESDGFLTPKEFVDSGDYLILQFPNWFWRSASEEYIVRWLPQNKQYLHIDNVPCRKRLDSSKLCISKNCLDITSDSKGDEWILPTNENVEKLGNININDDVRYYDISVTYDKFFQTPRIWLFGYNKEGYPLSTEEMVEDIISDYATKTITLDPHPFTGILCVSIHPCNHSSLLKKMAKNHPPHLSIVILLKFITTVIPSIELDNTIDIDIKFDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW25</accession>
    <name>Q5CW25_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted transmembrane domain, transmembrane domain within N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_1900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627094.1">
        <property type="nucleotide sequence ID" value="XM_627094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW25"/>
    <dbReference type="GeneID" id="3374466"/>
    <dbReference type="KEGG" id="cpv:cgd8_1900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1900"/>
    <dbReference type="InParanoid" id="Q5CW25"/>
    <dbReference type="OrthoDB" id="343693at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="114"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="913" mass="106868" checksum="D09C40C4F57197E7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW47</accession>
    <name>Q5CW47_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Partner of Nob1 Pno1p Yor145cp like KH domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_1650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PNO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627072.1">
        <property type="nucleotide sequence ID" value="XM_627072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW47"/>
    <dbReference type="FunCoup" id="Q5CW47">
        <property type="interactions" value="317"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW47"/>
    <dbReference type="GeneID" id="3374600"/>
    <dbReference type="KEGG" id="cpv:cgd8_1650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1650"/>
    <dbReference type="InParanoid" id="Q5CW47"/>
    <dbReference type="OMA" id="TPLRNNW"/>
    <dbReference type="OrthoDB" id="1932641at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22391">
        <property type="entry name" value="KH-I_PNO1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22392">
        <property type="entry name" value="KH-I_PNO1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000009">
        <property type="entry name" value="RNA-binding protein PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055212">
        <property type="entry name" value="KH-I_PNO1_first"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055211">
        <property type="entry name" value="KH_PNO1_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826">
        <property type="entry name" value="RIBONUCLEASE Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12826:SF13">
        <property type="entry name" value="RNA-BINDING PROTEIN PNO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22891">
        <property type="entry name" value="KH_PNO1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="6">
        <location>
            <begin position="118"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="213" mass="24286" checksum="2E12EF5FCFC6CB2E" modified="2005-04-12" version="1">MGETKSMDMDMVEEERRTEGPFKPLTGTEVNRSNEIRRVMVPENRMTPLKNQWINIVTPLVEHMGLHVRMNTKRRCVELKYGPDCTDIGSLQKGVDFIKAFLLGFELQDAIALLRLDDLYIESFEIKDVKRLNGAHLSRCIGRISGRDGKTKYAIENSTRTRIVLAGQKLHLMGAFHNIKLARDALCSLILGTPPGKVYNHLRIVSKRVQEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW65</accession>
    <name>Q5CW65_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Phosphorylated adapter RNA export protein</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">RNA U small nuclear RNA export adapter protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_1470</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PHAX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627054.1">
        <property type="nucleotide sequence ID" value="XM_627054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW65"/>
    <dbReference type="STRING" id="353152.Q5CW65"/>
    <dbReference type="GeneID" id="3374583"/>
    <dbReference type="KEGG" id="cpv:cgd8_1470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1470"/>
    <dbReference type="InParanoid" id="Q5CW65"/>
    <dbReference type="OMA" id="ICKICAT"/>
    <dbReference type="OrthoDB" id="20573at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006408">
        <property type="term" value="P:snRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1440">
        <property type="entry name" value="PHAX RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039047">
        <property type="entry name" value="PHAX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019385">
        <property type="entry name" value="PHAX_RNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038092">
        <property type="entry name" value="PHAX_RNA-binding_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135">
        <property type="entry name" value="CYTOSOLIC RESINIFERATOXIN BINDING PROTEIN RBP-26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13135:SF0">
        <property type="entry name" value="PHOSPHORYLATED ADAPTER RNA EXPORT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10258">
        <property type="entry name" value="PHAX_RNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Phosphorylated adapter RNA export protein RNA-binding" evidence="11">
        <location>
            <begin position="25"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="154" mass="18519" checksum="117B225A37B7B4A8" modified="2005-04-12" version="1">MKKKADFLNRLKLLKRDDREQIKLFSKLVRELKEPNIYLLERIVYFIPNELVYKTFNETRIIIKNGGYPTEDSTRLKSPGGIFFRLIKNQISHEEYKKIWNIQRQKKKNQRNKKLSLSKINDNEDIKGEKDDEYEDGELSEEAILMDDLKCMYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWA7</accession>
    <name>Q5CWA7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627012.1">
        <property type="nucleotide sequence ID" value="XM_627012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWA7"/>
    <dbReference type="GeneID" id="3374437"/>
    <dbReference type="KEGG" id="cpv:cgd8_1050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1050"/>
    <dbReference type="InParanoid" id="Q5CWA7"/>
    <dbReference type="OrthoDB" id="343317at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="698" mass="77486" checksum="2F9676C2E2083FC2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWA8</accession>
    <name>Q5CWA8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glycine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Diadenosine tetraphosphate synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_1030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.14" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627011.1">
        <property type="nucleotide sequence ID" value="XM_627011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWA8"/>
    <dbReference type="FunCoup" id="Q5CWA8">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWA8"/>
    <dbReference type="GeneID" id="3374436"/>
    <dbReference type="KEGG" id="cpv:cgd8_1030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1030"/>
    <dbReference type="InParanoid" id="Q5CWA8"/>
    <dbReference type="OMA" id="MEMQYFV"/>
    <dbReference type="OrthoDB" id="57698at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004820">
        <property type="term" value="F:glycine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070150">
        <property type="term" value="P:mitochondrial glycyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00774">
        <property type="entry name" value="GlyRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00858">
        <property type="entry name" value="GlyRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000004">
        <property type="entry name" value="Glycine--tRNA ligase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000010">
        <property type="entry name" value="Glycyl-tRNA synthetase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027031">
        <property type="entry name" value="Gly-tRNA_synthase/POLG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033731">
        <property type="entry name" value="GlyRS-like_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002315">
        <property type="entry name" value="tRNA-synt_gly"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00389">
        <property type="entry name" value="glyS_dimeric"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003211">
        <property type="entry name" value="PRK04173.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745:SF0">
        <property type="entry name" value="GLYCINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10745">
        <property type="entry name" value="GLYCYL-TRNA SYNTHETASE/DNA POLYMERASE SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01043">
        <property type="entry name" value="TRNASYNTHGLY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="173"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="656" mass="74949" checksum="E10B5E28107F47ED" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWG7</accession>
    <name>Q5CWG7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_5150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Deltex family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627837.1">
        <property type="nucleotide sequence ID" value="XM_627837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWG7"/>
    <dbReference type="STRING" id="353152.Q5CWG7"/>
    <dbReference type="GeneID" id="3375832"/>
    <dbReference type="KEGG" id="cpv:cgd6_5150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5150"/>
    <dbReference type="InParanoid" id="Q5CWG7"/>
    <dbReference type="OMA" id="HICTEIV"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007219">
        <property type="term" value="P:Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd09633">
        <property type="entry name" value="Deltex_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039396">
        <property type="entry name" value="Deltex_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039399">
        <property type="entry name" value="Deltex_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039398">
        <property type="entry name" value="Deltex_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12622">
        <property type="entry name" value="DELTEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18102">
        <property type="entry name" value="DTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="WWE" evidence="9">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="8">
        <location>
            <begin position="254"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="459" mass="53088" checksum="D49746CCEF37FD4E" modified="2007-04-03" version="1">MWRWWSDEGWVYYSLENSAVIEKSWRKKEVNIIINVGGIPFLLNLRHFYQFNFITQRHRRISRDISSAVWFWTDNDDQLNLYQPNVSAQIERFYLHIQWNLYKESQNDENSHHSHNNCQKSCKGSDALQPAINNELVKRPKSGECVVWNQYDIYPIECVQVNRITGKERKIYRRYLKKVEYEVTDNSQDSDKENDFNLEWEFTDTSKPQIQDALSIIVETGEFNCEGYSNAFTKQEIDFTVSKLLEQAQVDDDCCLCLDALNRDLVKLNKCSHVFHSECLNDMISHLNNKTALLCPLCMTPQCFGRGNSPPGKMRYIVYKSGNIEIESYPNTNVIEIEYFIPSGIQNQRHPSPNKLYTGTYKIAYLPFNKKGLIMLDGLAKAFQLGHTFKVNSITNPSTGSSMEIVQWGNIPHKISTCGGPALHGFPDPNFFTTLINKLSSLGIKCKHEESESHSEINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWG8</accession>
    <name>Q5CWG8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ERGIC-53-like mannose binding lectin that is a type I membrane protein, transmembrane domain near C, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_5140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627836.1">
        <property type="nucleotide sequence ID" value="XM_627836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWG8"/>
    <dbReference type="SMR" id="Q5CWG8"/>
    <dbReference type="STRING" id="353152.Q5CWG8"/>
    <dbReference type="GeneID" id="3375830"/>
    <dbReference type="KEGG" id="cpv:cgd6_5140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5140"/>
    <dbReference type="InParanoid" id="Q5CWG8"/>
    <dbReference type="OMA" id="FHSHAQH"/>
    <dbReference type="OrthoDB" id="270293at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005537">
        <property type="term" value="F:D-mannose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07308">
        <property type="entry name" value="lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051136">
        <property type="entry name" value="Intracellular_Lectin-GPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005052">
        <property type="entry name" value="Lectin_leg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223:SF28">
        <property type="entry name" value="LECTIN, MANNOSE BINDING 1 LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12223">
        <property type="entry name" value="VESICULAR MANNOSE-BINDING LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03388">
        <property type="entry name" value="Lectin_leg-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51328">
        <property type="entry name" value="L_LECTIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0430">Lectin</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253922" evidence="7">
        <location>
            <begin position="22"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="L-type lectin-like" evidence="8">
        <location>
            <begin position="44"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="469" mass="52432" checksum="D65FF231A3A4C28F" modified="2007-04-03" version="1">MVVRILYFLIICIWNVNIGFGHNDDPASAAHPSHDSIKQQKVDRIVMMRHSFESPLTLDTTLSEWDLAMATIPVRKSVVLVPGVKNRTGQFWNKSPLNTSHFEITFTFEVVGTPNSSQEGEGFAFWFVSEAYGSIYPKSNEDLELWNLLGYKNAPKGLGVMFSFLDRNNKKNPSISLLLSDGEKTFSSHTDIPTHLGVYYNFINSEGPTTFKLYVSPETGIIGQIRTSPTSKWIDCFKSDAKSIPSSIKNGGFIGFSSYTGPEVPNQPKVADRISIISLNVYNLDLTRAGEEIPDSLKHDSNTEQVEVTDLLRDTHVHGDKDVAEALKAFSQILYKHITEATPREQAIHRTLNSLLSQVQKLTTEIKEVQRILSINSGTNHSETLNTVQTEIVGLKTLFDRHSKYQTNTLIGLEDTLKNKEDVASQVHKAIKSQSSTTSIVSIALIIIIVVFGLVVWKKVKDIEKKHLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWT0</accession>
    <name>Q5CWT0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative integral membrane protein with 12 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627724.1">
        <property type="nucleotide sequence ID" value="XM_627724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWT0"/>
    <dbReference type="STRING" id="353152.Q5CWT0"/>
    <dbReference type="GeneID" id="3375740"/>
    <dbReference type="KEGG" id="cpv:cgd6_3870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3870"/>
    <dbReference type="InParanoid" id="Q5CWT0"/>
    <dbReference type="OMA" id="MLVVMRP"/>
    <dbReference type="OrthoDB" id="340100at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="254"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="316"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="341"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="412"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="476"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="500"/>
            <end position="521"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="540" mass="63491" checksum="ED8A1CD7F407B2F1" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWV2</accession>
    <name>Q5CWV2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_3600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627702.1">
        <property type="nucleotide sequence ID" value="XM_627702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWV2"/>
    <dbReference type="GeneID" id="3375723"/>
    <dbReference type="KEGG" id="cpv:cgd6_3600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3600"/>
    <dbReference type="InParanoid" id="Q5CWV2"/>
    <dbReference type="OMA" id="NNTSCIC"/>
    <dbReference type="OrthoDB" id="342081at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="249" mass="29206" checksum="883566DF0DEC5D44" modified="2005-04-12" version="1">MKFQSEKNEENKESINKSSSALINSLRNQINKVSALNKFRFINSNKKPLENEVQISDIADKIRNKISINKLNKSPGLEHTNNKYSEEIGGAYSPFRKRNKNNEKYSLQNKMSNFEQTRSELENLLLYNINKLRHERIKLKNCQMNKNNSHDENEILFPNIYTPLSSMKFMNIQELFLFLSLFYHNYQREWILPLLNNLKNLEIIFFTPESTSSSYSSTIITGRYTKILNEEYLFSSNAPISKLILNSAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX19</accession>
    <name>Q5CX19_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_2870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627635.1">
        <property type="nucleotide sequence ID" value="XM_627635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX19"/>
    <dbReference type="GeneID" id="3376159"/>
    <dbReference type="KEGG" id="cpv:cgd6_2870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2870"/>
    <dbReference type="InParanoid" id="Q5CX19"/>
    <dbReference type="OMA" id="TWDIMEG"/>
    <dbReference type="OrthoDB" id="336278at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="250" mass="28702" checksum="4D972D870C7D0DA0" modified="2007-04-03" version="1">MEIIRNIINIYLKKFLQLEDLKWDINQGLQVDHVRANSQSINKQFEEKGIPIQIYNGTLDSIKITYSPTNGTFQIHIKEINAQIKPRVLSTVGKKIQQGIVNIILDEDPIEFIDSYSYIRDLPISYLEQASKKSESSIADPDLIPDPPRFPTAALKIKQHTDYPPKYYPPLHFSIYKPKVTKMPATSTPLIFQNRCQEHHLPSSPLVYGPRNQSVPILQDFHSQFQPSYITNNNCENGHVRALRESGFCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX66</accession>
    <name>Q5CX66_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CpTSP6 extracellular membrane-associated protein with a signal peptide, an apple domain, TSP1 domain and a C-terminal transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_2310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627588.1">
        <property type="nucleotide sequence ID" value="XM_627588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX66"/>
    <dbReference type="SMR" id="Q5CX66"/>
    <dbReference type="GeneID" id="3376180"/>
    <dbReference type="KEGG" id="cpv:cgd6_2310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2310"/>
    <dbReference type="InParanoid" id="Q5CX66"/>
    <dbReference type="OMA" id="NTIINCS"/>
    <dbReference type="OrthoDB" id="336951at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254331" evidence="2">
        <location>
            <begin position="19"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="279"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="358" mass="40178" checksum="A696C73D6C508654" modified="2007-04-03" version="1">MNVLLLLLYLSLIYCSYCSIQRAGVKQINTLTPQSIERKEGTIIDQNSRNFCQYTDFRWSSCICDRNIMIGVRSLIKEQTENCSPEVTIIELPCDKSSCNQKLLTTSDGVACPSLANIDGVCDHSKNFLTDVMAKSFEMCRSFCSVMVNCTHFIMDTKNSRCKLYSGNKICGKEAPGITTGLAGFDTNPCSECTVGIWGGLSECKKPVDFDPNLLGCGEAVRRRISNGDVDADCPYRTETWTCSLPGQTCDMRTEISDIYLKSKPENDDKSESYKLLEISLIFAGIVTGILIFVPTSLIFPKIGQFFYGKRLYSLLSGNELDSSRTPVNETINNPDDYEEWEEDMNVEYETEFTIDNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXF2</accession>
    <name>Q5CXF2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627502.1">
        <property type="nucleotide sequence ID" value="XM_627502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXF2"/>
    <dbReference type="GeneID" id="3376005"/>
    <dbReference type="KEGG" id="cpv:cgd6_1310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1310"/>
    <dbReference type="InParanoid" id="Q5CXF2"/>
    <dbReference type="OMA" id="SEKYCIS"/>
    <dbReference type="OrthoDB" id="338251at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="432" mass="50114" checksum="16BE5406943E2ED9" modified="2007-04-03" version="1">MEISENTFQDVKLDKFPDLDGNQFKRNDTAVSELCDSKYSIGKKIFPENSDHHRPEDNKAKQFKKSDEQSEKATNNEDMENLNNASNLFDVKGSQKPKNLSDNSLDHDSNVDNSQVSARIIMLDLDNTLIPTNWIMQTWRNIQCEMGNEGDSIDYGENESSLYELTEQIRNELVQVGLFDLLDQFFSDLWSTGMAYKIVIITNAGLRTVELFYLKYCLPKLGDILKKYNVEINSTEEYIRKKGPPPSPFSEEEYREFYTNAKLHEFQKVLLDCWGNNLECNDDFPSMFDVISAGDQACEMTAACRISKFYENKIRRTKLIYIHDPEDFRFWKQKPESFMKQLSETHRELLNLLSDDSETLIGCSDMNSTGFTNLEEENDEEFEEVALGWYCKGKYINIAISKPERFVLPQGSSETYLETERDYFEKEVGMAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXH0</accession>
    <name>Q5CXH0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_1120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627484.1">
        <property type="nucleotide sequence ID" value="XM_627484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXH0"/>
    <dbReference type="GeneID" id="3376028"/>
    <dbReference type="KEGG" id="cpv:cgd6_1120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1120"/>
    <dbReference type="InParanoid" id="Q5CXH0"/>
    <dbReference type="OrthoDB" id="341192at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253944" evidence="2">
        <location>
            <begin position="22"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="817" mass="95336" checksum="7C68A21A9F60DCD4" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXI0</accession>
    <name>Q5CXI0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor if-4E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_1020</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eukaryotic initiation factor 4E family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627474.1">
        <property type="nucleotide sequence ID" value="XM_627474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXI0"/>
    <dbReference type="FunCoup" id="Q5CXI0">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXI0"/>
    <dbReference type="GeneID" id="3376097"/>
    <dbReference type="KEGG" id="cpv:cgd6_1020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1020"/>
    <dbReference type="InParanoid" id="Q5CXI0"/>
    <dbReference type="OMA" id="WVIWEQI"/>
    <dbReference type="OrthoDB" id="590761at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000340">
        <property type="term" value="F:RNA 7-methylguanosine cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.760.10">
        <property type="entry name" value="RNA Cap, Translation Initiation Factor Eif4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023398">
        <property type="entry name" value="TIF_eIF4e-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001040">
        <property type="entry name" value="TIF_eIF_4E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11960:SF8">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4E1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01652">
        <property type="entry name" value="IF4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55418">
        <property type="entry name" value="eIF4e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0810">Translation regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="240" mass="27026" checksum="2890A750ACBAE8E7" modified="2007-04-03" version="1">MTEKEVVSKYLSFNESIEPNLTLPTACSEVDLPEDLISRPLPLSHEWIVWEQLNVETRKDLDYSNATKPVARFSSVQQFWWLWHNIPQPSELLKGKRMIRESSDGSKSVVDAVILFKEGIQPMWEDPMNATGGHIHFRAWQSSVVPGELDTMWNNLVLAVIGGSLENSSIVNGIRLVDKLGGNKGNIRVEIWFSDFSNQSAHQALLKEIETLMSSLLDGTSCEPPHFEVKSHSKSKPDAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXJ3</accession>
    <name>Q5CXJ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative apicomplexan conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GET4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627461.1">
        <property type="nucleotide sequence ID" value="XM_627461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXJ3"/>
    <dbReference type="FunCoup" id="Q5CXJ3">
        <property type="interactions" value="124"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXJ3"/>
    <dbReference type="GeneID" id="3376085"/>
    <dbReference type="KEGG" id="cpv:cgd6_870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_870"/>
    <dbReference type="InParanoid" id="Q5CXJ3"/>
    <dbReference type="OMA" id="IFKKCPP"/>
    <dbReference type="OrthoDB" id="10252405at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045048">
        <property type="term" value="P:protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007317">
        <property type="entry name" value="GET4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12875:SF0">
        <property type="entry name" value="GOLGI TO ER TRAFFIC PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04190">
        <property type="entry name" value="GET4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="297" mass="34637" checksum="6AFC5674BA0449BA" modified="2007-04-03" version="1">MDKIWNVVKSRLEKGDSYDAYQLLISRLSRFNPKDSVEFGLEKAKYFDEYGFNEIACHVCSSMIKKAREEKLKITNSQFNSVMYILSSGRFCNEKGKLLNDTLLWCKDHENENTDYIYKLHVWASNYYFVHQNFSKAQLYVILTENPELFANILIEWSKKGYKSEKDIFLLRAVLVLLSLNKTQFAHDLLDKYCQLLNESNDTSLSLSSSCNSNIDSNIPSAPIQMAFFIISACELSDKKTAMHFFDIIKNKYALLIRRDSSFSRIIDKIDQIYFNRQKNASFNMLSNLLSMFNTNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXM3</accession>
    <name>Q5CXM3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc ZIP transporter protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_490</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627431.1">
        <property type="nucleotide sequence ID" value="XM_627431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXM3"/>
    <dbReference type="STRING" id="353152.Q5CXM3"/>
    <dbReference type="TCDB" id="2.A.5.3.7">
        <property type="family name" value="the zinc (zn(2+))-iron (fe(2+)) permease (zip) family"/>
    </dbReference>
    <dbReference type="GeneID" id="3376043"/>
    <dbReference type="KEGG" id="cpv:cgd6_490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_490"/>
    <dbReference type="InParanoid" id="Q5CXM3"/>
    <dbReference type="OMA" id="SIAQYKW"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="398"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="148"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="159"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="437" mass="48778" checksum="E0B08B9AE617F39D" modified="2005-04-12" version="1">MNKLILSKILSFISVIFVGGIGVYIPIYIGYLNPILLQYINVFAGGTLLSLSLCHLIPEAEEIVRANDISLKFIGVEIPIVAYLTLFGLTIILFFEKALFSPQDVAQFHMHDHSFPHNRDHHHHHHKDPGCVGVSNSDVYSIVNGEKKSHYHHHHRNDNNNNNNNNNNNNNNNNNNNSNSNSFSFTCPSEGNSDSNIIIPINSQTCESNNYNNMHYEESDSKNLGIKSPLIESSELYNEKSNMINNQHRNISTSQVSLKQESNIQKSKTNSTLNVYFLVSALSVHAIFEGMLVGISKNHISVLTITLVIIAHKWVEGIAVSAGIKKHTEISKTTVNQLLISFILMSPLGIIIGQLFSYINSPLINVVLTCISSGALLYVALGEMILDEFNCGENRKQKFILFLLGILLVSIINIIQHKLGGCTLHHHHHGHSHIHTH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXM5</accession>
    <name>Q5CXM5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627429.1">
        <property type="nucleotide sequence ID" value="XM_627429.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3376107"/>
    <dbReference type="KEGG" id="cpv:cgd6_460"/>
    <dbReference type="InParanoid" id="Q5CXM5"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="191" mass="22465" checksum="B24EDBEBD3B3A1D6" modified="2005-04-12" version="1">MLYLKKNPGILYVTRNNIIWISDKVKGQPFESISILKESYSKIISETDNNLNYNDEVSSSKNNLNLANDFVVELWQNLYAHRKRDDKRLVGLRFENKEIKDKVNSNLFIDINLTLNSNDDFNNFLQLISDCHSKAIERYXKLXELKEKKQSENSNSIENKILEFNKVEKNVNKRIVIEKKVKPKGKSLYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXP0</accession>
    <name>Q5CXP0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_5470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628690.1">
        <property type="nucleotide sequence ID" value="XM_628688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXP0"/>
    <dbReference type="GeneID" id="3372153"/>
    <dbReference type="KEGG" id="cpv:cgd7_5470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5470"/>
    <dbReference type="InParanoid" id="Q5CXP0"/>
    <dbReference type="OMA" id="ERCLINI"/>
    <dbReference type="OrthoDB" id="341818at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="402" mass="45672" checksum="393338A4CC2C4979" modified="2005-04-12" version="1">MSNSPEKIQLLASTGLRSYSDEELPVITPCSAPYSSTSLNRDFISNSIAKSFPSIKVYSEQDGTYITFHIKSVETTVANLKNFIGSLKDNKRTHNSSLDSQASTMDSDLNLSRQIKEGELSLFEQNIQIYGEIPGLPKRILSDSDRILQVIRETDNLKLYYLYESFENKKGTQNELIVIVYPKANLHELGIKCFITISGSGLKFIPVDETKSSKRIIFISFDDVCSVTVYKQVENSLLIKRRTIGKSPFLIRASSSVDFTVIKRRLKQASELQKDSSLISDADSRLSKCKLQFNNVELMTKMNALTTFFEFVGSEFGRIFFSNWIKSIEEDSKKSSELKVLKEKSENNSLSHLITFTKIKEGLINQDYFSLSEEKELNDFIVEFQRYLSEASPSLEDILQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY25</accession>
    <name>Q5CY25_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_3940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628555.1">
        <property type="nucleotide sequence ID" value="XM_628553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY25"/>
    <dbReference type="FunCoup" id="Q5CY25">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY25"/>
    <dbReference type="GeneID" id="3371941"/>
    <dbReference type="KEGG" id="cpv:cgd7_3940"/>
    <dbReference type="InParanoid" id="Q5CY25"/>
    <dbReference type="OMA" id="PENYMHR"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000849">
        <property type="entry name" value="ATP-dependent RNA helicase DBP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="12">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="53"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="235"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="22"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK90638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="396" mass="45236" checksum="61D36CB0828B552E" modified="2005-04-12" version="1" fragment="single">TMNYVENDIVVYNSSEKCKVYNTFEEMGLKDNLLRGIYSYGFEFPSAIQRRAIVPIIQGRDTIIQSQSGTGKTCVFSVGALEICSKSKENVPMVLILSPTRELAEQSEKVCTSIGDYLDIRAHSCIGGKKLKDDIKALNSGVSIISGTPGRVLQMIEQGYLSTKKIKLLIIDEADEMFDYGFKTQVYDIYKYLPPRIQTVLVSATLPDDILVMAQKFMRNPLQILVPKEEVSLDKIRQYHVQVEEEKWKFETLCDLYDTLTVTQSIIFCNTKNKVEWLSKKMMENHFTVSFVHGDLPQVTREEILREFREGKTRVLITTDLWGRGIDVQQVNLVVNYDLPINKELYIHRIGRSGRFGRSGIAINLITKEDESMLSLLERFYSIKISKLPGNVKNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY28</accession>
    <name>Q5CY28_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cysteine rich protein with two potential transmembrane domain regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_3910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628552.1">
        <property type="nucleotide sequence ID" value="XM_628550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY28"/>
    <dbReference type="GeneID" id="3372138"/>
    <dbReference type="KEGG" id="cpv:cgd7_3910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3910"/>
    <dbReference type="InParanoid" id="Q5CY28"/>
    <dbReference type="OMA" id="NAISIMW"/>
    <dbReference type="OrthoDB" id="341403at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005637">
        <property type="term" value="C:nuclear inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071763">
        <property type="term" value="P:nuclear membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044780">
        <property type="entry name" value="Heh2/Src1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018996">
        <property type="entry name" value="Man1/Src1-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808">
        <property type="entry name" value="INNER NUCLEAR MEMBRANE PROTEIN HEH2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47808:SF2">
        <property type="entry name" value="LEM DOMAIN-CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09402">
        <property type="entry name" value="MSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="230"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="455"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="domain" description="Man1/Src1-like C-terminal" evidence="7">
        <location>
            <begin position="266"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF09402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="565" mass="65180" checksum="600909A176A4FF65" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYC5</accession>
    <name>Q5CYC5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_2880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628455.1">
        <property type="nucleotide sequence ID" value="XM_628453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYC5"/>
    <dbReference type="GeneID" id="3372273"/>
    <dbReference type="KEGG" id="cpv:cgd7_2880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2880"/>
    <dbReference type="InParanoid" id="Q5CYC5"/>
    <dbReference type="OrthoDB" id="10507491at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="148" mass="16819" checksum="DF304695F88D8B40" modified="2005-04-12" version="1">MQDEFVDHKLETELFSILSPELLNEIMIEEFPHIRLGPSVSQVLTTLTNGFIQDVVKNSYIISKHKNHSEVQADDILVYLRMKYPDTKLEEFCETISQRKEGRSGAGTLESEEGNAVSNSGLLSIKLFNTERFKSNSKIINNLRNSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYH2</accession>
    <name>Q5CYH2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical small protein, possible signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_2350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628408.1">
        <property type="nucleotide sequence ID" value="XM_628406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYH2"/>
    <dbReference type="GeneID" id="3372204"/>
    <dbReference type="KEGG" id="cpv:cgd7_2350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2350"/>
    <dbReference type="InParanoid" id="Q5CYH2"/>
    <dbReference type="OMA" id="FINATFQ"/>
    <dbReference type="OrthoDB" id="339210at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="175" mass="20333" checksum="189994817251F679" modified="2005-04-12" version="1">MSFFALFISIYLFAFLYGNVPWMELSTWKSYPYKEYSLPKMILKSKSSSSLNEVVLSSPFLNGTFTKVGHKRYDYPIYELNQVGNGCKHYINYDVTIPPGKLHTFLKDFICYSYLGGWIIYSSCQKSYENPLGYNSIRAIGYPAYGKFRNVSIPVDVKDWYHAIHNHIRVPIKVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYJ2</accession>
    <name>Q5CYJ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628388.1">
        <property type="nucleotide sequence ID" value="XM_628386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYJ2"/>
    <dbReference type="GeneID" id="3371891"/>
    <dbReference type="KEGG" id="cpv:cgd7_2120"/>
    <dbReference type="InParanoid" id="Q5CYJ2"/>
    <dbReference type="OrthoDB" id="339222at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254387" evidence="1">
        <location>
            <begin position="21"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="136" mass="15747" checksum="3DECE5AAA2B8E1A7" modified="2005-04-12" version="1">MKKTIFFIIICVLIWDFISTQSTVIPSFIPINEGIPDNELSRLSLEVLPIISHKFKIQIFSDRIRIDSRPKCYNSQGFDGKDTVKVSVFFFILPYLHATFFPQGCEIGVYICDHDFHKQCLWVHKSHCQCSSPGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYN2</accession>
    <name>Q5CYN2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Meiotic recombination protein DMC1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd7_1690</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RecA family. DMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628348.1">
        <property type="nucleotide sequence ID" value="XM_628346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYN2"/>
    <dbReference type="SMR" id="Q5CYN2"/>
    <dbReference type="FunCoup" id="Q5CYN2">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYN2"/>
    <dbReference type="GeneID" id="3371733"/>
    <dbReference type="KEGG" id="cpv:cgd7_1690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1690"/>
    <dbReference type="InParanoid" id="Q5CYN2"/>
    <dbReference type="OMA" id="ANPMKPV"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000239">
        <property type="entry name" value="Meiotic recombination protein DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011940">
        <property type="entry name" value="Dmc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02238">
        <property type="entry name" value="recomb_DMC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF30">
        <property type="entry name" value="MEIOTIC RECOMBINATION PROTEIN DMC1_LIM15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0469">Meiosis</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="10">
        <location>
            <begin position="101"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="11">
        <location>
            <begin position="279"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="342" mass="37220" checksum="4A139724865AE64F" modified="2005-04-12" version="1">MSAFCQSKSVAKQVSAKGVEEEAFVEIDKLQSAGINVADINKLKTAGLCTVLSIIQATKKELCNIKGLSEAKVEKIVEAAQKLDQSSSFQSGSEVMSRRQNILRITTGSEQFDKMLMGGFESMCITEIFGENRCGKTQICHTLCVAAQLPLEMNGGNGKVCFIDTEGTFRPERIVKIAERFGVQGDVALDNIMYARAYTHEHLNQLISAAAGKMIEEKFALLIVDSIIALFRTEFSGRGELAERQQILNKTLSKLNKLADQFNIAIVMTNHVMADPAGGMSFMPNVAKPVGGHVIGHASHVRLSLRKGKGEQRVCKVYGSPHLPESECVIQLSDGGIIDPID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYN5</accession>
    <name>Q5CYN5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Protein with signal peptide and 6 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_1650</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628345.1">
        <property type="nucleotide sequence ID" value="XM_628343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYN5"/>
    <dbReference type="GeneID" id="3371732"/>
    <dbReference type="KEGG" id="cpv:cgd7_1650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1650"/>
    <dbReference type="InParanoid" id="Q5CYN5"/>
    <dbReference type="OMA" id="HALMCIL"/>
    <dbReference type="OrthoDB" id="339894at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253981" evidence="12">
        <location>
            <begin position="33"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="71"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="269"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK90212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="344" mass="39280" checksum="567162E591842429" modified="2005-04-12" version="1">MLAILKGASCKKVIFSCFLLVIFLANISQILAEDQGTTSTQNSSQNESSNKKNFLFLSLNKYVWVHDACSWFHALMCITCYGVITFKVYSDRSALGISMQTLCALCFSEFCGALLNVWFSLYTGITLDWSFQIDIISTFLSVLCLYTVWKKFSNSIEDQYDTFGLNILVRILSIMGSKSVDKDAMRNGERAGKIKPTGITGLISGSLYWLVLYILAIPLSFIFLMFRTRRRLGLITSLLAYDDAVRALALVPQLYMFHIKSPRKVSEHLALFVVFEFILKVLALFYWISMPLFRMPHESRNYNIAVQIFNIGILLDFAYHYFRAKFNGEKTIQYASDLIIPFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYT0</accession>
    <name>Q5CYT0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_1150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628300.1">
        <property type="nucleotide sequence ID" value="XM_628298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYT0"/>
    <dbReference type="STRING" id="353152.Q5CYT0"/>
    <dbReference type="GeneID" id="3371843"/>
    <dbReference type="KEGG" id="cpv:cgd7_1150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1150"/>
    <dbReference type="InParanoid" id="Q5CYT0"/>
    <dbReference type="OMA" id="YATTINI"/>
    <dbReference type="OrthoDB" id="294052at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901096">
        <property type="term" value="P:regulation of autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039272">
        <property type="entry name" value="CLEC16A/TT9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019155">
        <property type="entry name" value="CLEC16A/TT9_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21481:SF0">
        <property type="entry name" value="PROTEIN CLEC16A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09758">
        <property type="entry name" value="FPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FPL" evidence="2">
        <location>
            <begin position="71"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1191" mass="141935" checksum="124594166232586F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYT5</accession>
    <name>Q5CYT5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NTF2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_1090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628295.1">
        <property type="nucleotide sequence ID" value="XM_628293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYT5"/>
    <dbReference type="GeneID" id="3372001"/>
    <dbReference type="KEGG" id="cpv:cgd7_1090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1090"/>
    <dbReference type="InParanoid" id="Q5CYT5"/>
    <dbReference type="OMA" id="QIFHIMD"/>
    <dbReference type="OrthoDB" id="339303at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NTF2" evidence="2">
        <location>
            <begin position="26"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="337"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="228"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="337"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="396" mass="43992" checksum="CD2AFF58403EC2E1" modified="2005-04-12" version="1">MVSSRSASPNRRGSTGSSSISSINTRIVPFISNYYSLLGDSPNSLIDLHVSNPDPHLKWQIPSFIIGGNPRLQGSTIIDNGIISIKSFGKDTLHNLFSSLPTITCKIPVEIMDINETTENIVTVSIHGYVISGIERLLFFQVLQLFHQIDLNNKDNFLIFNNIFYVFPIPFDMKSIRSLQTFSNQHSISHSFSLAHTPKSTGSEDYDNNTNEIGHETTGNHSHNLSYQQQHQHSTHQQNHHVKTFPTYQDSKKTTKIKPQIKIHGLSANSGLSDKDILSAVSFQLKNSNEGFAIAINRNNDEAIIQVDSVQSQELLSQRGIYIQGLKYKVSNVVKKSNSGIKGNRNSNKNNNQAEVSGPSSSSAPKKMNSHKKESIPDKDGWITVTSKGKSKSKTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYU9</accession>
    <name>Q5CYU9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hypothetical transmembrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628281.1">
        <property type="nucleotide sequence ID" value="XM_628279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYU9"/>
    <dbReference type="GeneID" id="3371990"/>
    <dbReference type="KEGG" id="cpv:cgd7_930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_930"/>
    <dbReference type="InParanoid" id="Q5CYU9"/>
    <dbReference type="OMA" id="TCTISII"/>
    <dbReference type="OrthoDB" id="342385at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140042">
        <property type="term" value="P:lipid droplet formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009617">
        <property type="entry name" value="Seipin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212">
        <property type="entry name" value="BERNARDINELLI-SEIP CONGENITAL LIPODYSTROPHY 2 HOMOLOG BSCL2 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21212:SF0">
        <property type="entry name" value="SEIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06775">
        <property type="entry name" value="Seipin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="34"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="416"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="545"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="562"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="578" mass="67221" checksum="709991F6CBE980F5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYW0</accession>
    <name>Q5CYW0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628270.1">
        <property type="nucleotide sequence ID" value="XM_628268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYW0"/>
    <dbReference type="FunCoup" id="Q5CYW0">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYW0"/>
    <dbReference type="GeneID" id="3371773"/>
    <dbReference type="KEGG" id="cpv:cgd7_810"/>
    <dbReference type="InParanoid" id="Q5CYW0"/>
    <dbReference type="OMA" id="YRCENQA"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="5">
        <location>
            <begin position="125"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="322" mass="37245" checksum="9EDB5818F32F5149" modified="2005-04-12" version="1" fragment="single">ERQLFSRMPKGLDVYLDSLKLDREISTLLECKTLSENEVKQLCELAKDILEEEQNVQQIGLPLTVVGDIHGQFFDLKEIFRIGGVPPETNFLFLGDYVDRGYYSVESVTLIVALKVRYRNRVFLIRGNHESRQITQVYGFYDECLRKYGTPNVWRYFTDLFDYLPLSALIDNKIFCPHAGLSPSLPSLDSIKSLDRIQEVPHEGPMCDLLWSDPDERYGWGVSHRGAGYTFGEDVSEMFNHTNNLQLICRAHQLILDGYQWSHNKNVVTVFSAPNYCYRCENQAAILRIDDLGNFTFLQFDHAPEKVLPRQENQLPVPDYFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPQ0</accession>
    <name>A3FPQ0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_3760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 15">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 15">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388396.1">
        <property type="nucleotide sequence ID" value="XM_001388359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPQ0"/>
    <dbReference type="FunCoup" id="A3FPQ0">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPQ0"/>
    <dbReference type="GeneID" id="3371838"/>
    <dbReference type="KEGG" id="cpv:cgd7_3760"/>
    <dbReference type="InParanoid" id="A3FPQ0"/>
    <dbReference type="OMA" id="YACTVAT"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08215">
        <property type="entry name" value="STKc_Nek"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF6">
        <property type="entry name" value="SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000654">
        <property type="entry name" value="Integrin-linked_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="1"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAZ51589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="255" mass="28935" checksum="65320F808FEB93E1" modified="2007-04-03" version="1" fragment="single">VGSGSYGKAILVKDIYKGRDYVMKIINISKLSSNERKDAINEVKLLSSIRHPYIVCFRESFVEDGFLNIVMEYADGGDLFRKVNAQKQLKKNFLENQVVRWLTQALLGLAHLHNKRILHRDIKSQNIFISYNGLKIGDFGIAKVLENTGAFAKTTIGTPYYLSPEICLSKPYSWSSDIWALGCVAYEMCSLKVPFDAPNLKTLVEKITNGIFLPISNSYSEGLRRVIMDMLIIDSSQRPTVMELLKYPIIEVRNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPQ3</accession>
    <name>A3FPQ3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sm protein G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_3970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388399.1">
        <property type="nucleotide sequence ID" value="XM_001388362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPQ3"/>
    <dbReference type="FunCoup" id="A3FPQ3">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPQ3"/>
    <dbReference type="GeneID" id="3371840"/>
    <dbReference type="KEGG" id="cpv:cgd7_3970"/>
    <dbReference type="InParanoid" id="A3FPQ3"/>
    <dbReference type="OMA" id="IMWECID"/>
    <dbReference type="OrthoDB" id="274944at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043186">
        <property type="term" value="C:P granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034719">
        <property type="term" value="C:SMN-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF2">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="4">
        <location>
            <begin position="1"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00041356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="62" mass="6940" checksum="5A36363771E9C736" modified="2007-04-03" version="1" fragment="single">SLIVKLNGNRQIIGSLRGYDNFMNLVLENTTEVLDSTKKSIGTTVIRGNSVIMWECIDKVKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPR7</accession>
    <name>A3FPR7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_4870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388413.1">
        <property type="nucleotide sequence ID" value="XM_001388376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPR7"/>
    <dbReference type="STRING" id="353152.A3FPR7"/>
    <dbReference type="GeneID" id="3371815"/>
    <dbReference type="KEGG" id="cpv:cgd7_4870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4870"/>
    <dbReference type="InParanoid" id="A3FPR7"/>
    <dbReference type="OMA" id="GLECMAT"/>
    <dbReference type="OrthoDB" id="341976at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAZ51606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="137" mass="16027" checksum="3B5DF8C4DD35D577" modified="2007-04-03" version="1" fragment="single">MECLICFADLDEINSVDYKTSSDSEWFKSLFCFECITTLKKTQFKRYCDSVTETKCLKEQKSLLRRGPPINIYDKHGFPECGENEVFMLCKSNSKDIICPKLDGSLVGEDRIKYWDYLKQFISKDLLEDDLSKDEEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPS8</accession>
    <name>A3FPS8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">26s protease regulatory subunit 8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388307.1">
        <property type="nucleotide sequence ID" value="XM_001388270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPS8"/>
    <dbReference type="FunCoup" id="A3FPS8">
        <property type="interactions" value="282"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPS8"/>
    <dbReference type="GeneID" id="3375932"/>
    <dbReference type="KEGG" id="cpv:cgd6_920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_920"/>
    <dbReference type="InParanoid" id="A3FPS8"/>
    <dbReference type="OMA" id="REPAVIF"/>
    <dbReference type="OrthoDB" id="1154031at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000006">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000044">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="170"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="23"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="393" mass="44613" checksum="BB42FA54DCDA043A" modified="2007-04-03" version="1">MLDSINPASSYYSKRIEHLKILIDSKKLDIRRLHAQRNELNSKVKELKDELQYLLESNSYVGEVIKVMGRNKVLVKLNPEGKFLVDVSKNIDISKCTTNTRVALLSDSFKLHRIFPNKVDPLVSLMKVEKVPDSTYDMVGGLDEQIKEIKEVIELPIKHPEIFESLGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKYIGEGSRMVRELFVMAREHAPSLIFMDEIDSIGSQRTEGESGDSEVQRTMLELLNQLDGFESTQNIKIIMATNRIDILDDALLRPGRIDRKIEFPNPNEDARLEILKIHSRKMNLVRGIDLRKVAQQMQGASGAESKAVCTEAGMFALRERRKHVTQEDFDMAVSRVMKKDSDWNMSLKKLWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPS9</accession>
    <name>A3FPS9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388308.1">
        <property type="nucleotide sequence ID" value="XM_001388271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPS9"/>
    <dbReference type="STRING" id="353152.A3FPS9"/>
    <dbReference type="GeneID" id="3375933"/>
    <dbReference type="KEGG" id="cpv:cgd6_970"/>
    <dbReference type="InParanoid" id="A3FPS9"/>
    <dbReference type="OMA" id="APEMICM"/>
    <dbReference type="OrthoDB" id="337284at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24351">
        <property type="entry name" value="RIBOSOMAL PROTEIN S6 KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="1"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="175" mass="20420" checksum="245E559566A1096C" modified="2007-04-03" version="1" fragment="single">VAKVIGSLHKEGIIHRDIKCSNIIIESETEKIKLIDMSLSCFVDTKKQRLSEFCGSFHTMAPEMICMQKPNYSIEYDWWSFGVLIYEMVFGINFSIPPYGYHPEENKYLLKRINESPKSLSFPEPVIFMGDFIQGRKNREETEDLIMKLLNKDESIRLGSNGDFKQVIEHPWFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ01</accession>
    <name>A3FQ01_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388442.1">
        <property type="nucleotide sequence ID" value="XM_001388405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ01"/>
    <dbReference type="GeneID" id="3374356"/>
    <dbReference type="KEGG" id="cpv:cgd8_4310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4310"/>
    <dbReference type="InParanoid" id="A3FQ01"/>
    <dbReference type="OrthoDB" id="361676at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="153"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="171"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="204" mass="22694" checksum="F7112495DC8EB155" modified="2007-04-03" version="1">MQLASTRSGNNESFKCDILKIGPLAFAPNSEEITDIMDGSLGFLNGNMLSIYYNSIPKASFSLESIELPVHNVDAAPGCIGFKYHGTDQIICATGKDSQSAWINAITEAWFCRNLGLAGTLPSISDNQSKFTKKNLNNLNLYIHLLLLIEEEEQEEGETEENEENSDKKQKENKKKKKSSRLVRSSVKTFTVELEDGKPKITQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ19</accession>
    <name>A3FQ19_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">UBA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388099.1">
        <property type="nucleotide sequence ID" value="XM_001388062.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ19"/>
    <dbReference type="GeneID" id="3373941"/>
    <dbReference type="KEGG" id="cpv:cgd3_1180"/>
    <dbReference type="InParanoid" id="A3FQ19"/>
    <dbReference type="OrthoDB" id="343727at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010314">
        <property type="entry name" value="E3_Ub_ligase_DUF913"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06025">
        <property type="entry name" value="DUF913"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="1679"/>
            <end position="1723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1954"/>
            <end position="1978"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2022"/>
            <end position="2055"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2351"/>
            <end position="2388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2925"/>
            <end position="3072"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3142"/>
            <end position="3187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3239"/>
            <end position="3320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3533"/>
            <end position="3552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3593"/>
            <end position="3612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3794"/>
            <end position="3831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1957"/>
            <end position="1973"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2027"/>
            <end position="2048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2361"/>
            <end position="2377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2935"/>
            <end position="2976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2986"/>
            <end position="3053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="3170"/>
            <end position="3187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="3239"/>
            <end position="3249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3250"/>
            <end position="3273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="3819"/>
            <end position="3831"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="3">
        <location>
            <position position="2943"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="3">
        <location>
            <position position="3182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="3868" mass="442791" checksum="DF415DF8B56A022F" modified="2013-05-29" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ41</accession>
    <name>A3FQ41_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_3140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388121.1">
        <property type="nucleotide sequence ID" value="XM_001388084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ41"/>
    <dbReference type="STRING" id="353152.A3FQ41"/>
    <dbReference type="GeneID" id="3373825"/>
    <dbReference type="KEGG" id="cpv:cgd3_3140"/>
    <dbReference type="InParanoid" id="A3FQ41"/>
    <dbReference type="OMA" id="EHSERDQ"/>
    <dbReference type="OrthoDB" id="341170at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="29"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="185"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="252"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="303"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="92"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="785" mass="91483" checksum="C25B0A6AC8F3D85B" modified="2007-04-03" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ52</accession>
    <name>A3FQ52_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sexual stage-specific protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_4310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388132.1">
        <property type="nucleotide sequence ID" value="XM_001388095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ52"/>
    <dbReference type="STRING" id="353152.A3FQ52"/>
    <dbReference type="GeneID" id="3373814"/>
    <dbReference type="KEGG" id="cpv:cgd3_4310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4310"/>
    <dbReference type="InParanoid" id="A3FQ52"/>
    <dbReference type="OMA" id="ICRENPF"/>
    <dbReference type="OrthoDB" id="371082at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050167">
        <property type="entry name" value="Ser_Thr_protein_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23257">
        <property type="entry name" value="SERINE-THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="2">
        <location>
            <begin position="311"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="435"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="751" mass="87460" checksum="241D445F6DB78628" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ81</accession>
    <name>A3FQ81_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Translation elongation factor EF-1, subunit alpha, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_2070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388217.1">
        <property type="nucleotide sequence ID" value="XM_001388180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ81"/>
    <dbReference type="FunCoup" id="A3FQ81">
        <property type="interactions" value="218"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ81"/>
    <dbReference type="GeneID" id="3373438"/>
    <dbReference type="KEGG" id="cpv:cgd2_2070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2070"/>
    <dbReference type="InParanoid" id="A3FQ81"/>
    <dbReference type="OMA" id="IERYEEC"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03704">
        <property type="entry name" value="eRF3_C_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04089">
        <property type="entry name" value="eRF3_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000020">
        <property type="entry name" value="Translation elongation factor EF-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001202">
        <property type="entry name" value="Translation elongation factor EF-1 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="7">
        <location>
            <begin position="78"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="54"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="525" mass="58637" checksum="27EC92BD95FF07E3" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQG2</accession>
    <name>A3FQG2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">dUTPase-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_3860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388184.1">
        <property type="nucleotide sequence ID" value="XM_001388147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQG2"/>
    <dbReference type="STRING" id="353152.A3FQG2"/>
    <dbReference type="GeneID" id="3371385"/>
    <dbReference type="KEGG" id="cpv:cgd1_3860"/>
    <dbReference type="InParanoid" id="A3FQG2"/>
    <dbReference type="OMA" id="WFKIAAY"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="2">
        <location>
            <begin position="18"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="232" mass="25461" checksum="D0690EB1BD52E139" modified="2007-04-03" version="1" fragment="single">DWFKIAAYDDYNEPSSYTIVGRSSISKSPLRLAVPGGIFDAGFRGELRIPFDNIKDYDYELKIGQRYVSLTGYDGKPVSFSLVDQLDETDRGERGLGSTGLGPVVLGNTGEETRSKSLNQALVNETRTSLSRVVPLSTNRTSESQLVKSMKPLTGQSEKSLKSRTPLNSFIFPQASNVQVFNIMSSDSQALLVNVLPSKSLTERVDIAKSVIITSIPENESRNNTSLNITKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPP3</accession>
    <name>Q5CPP3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter family protein, 2x AAA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd2_80</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625378.1">
        <property type="nucleotide sequence ID" value="XM_625378.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPP3"/>
    <dbReference type="GeneID" id="3372374"/>
    <dbReference type="KEGG" id="cpv:cgd2_80"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_80"/>
    <dbReference type="InParanoid" id="Q5CPP3"/>
    <dbReference type="OMA" id="FWESEIN"/>
    <dbReference type="OrthoDB" id="4865934at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="102"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="258"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="838"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="877"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="918"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="949"/>
            <end position="971"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="977"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1007"/>
            <end position="1028"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1061"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1090"/>
            <end position="1112"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="481"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="931"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK87390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1476" mass="171014" checksum="76A9A1FDE5B6EEE1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPU1</accession>
    <name>Q5CPU1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Yer006wp-like. Yjeq GTpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_4040</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625423.1">
        <property type="nucleotide sequence ID" value="XM_625423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPU1"/>
    <dbReference type="STRING" id="353152.Q5CPU1"/>
    <dbReference type="GeneID" id="3372407"/>
    <dbReference type="KEGG" id="cpv:cgd4_4040"/>
    <dbReference type="InParanoid" id="Q5CPU1"/>
    <dbReference type="OMA" id="FKLDGLW"/>
    <dbReference type="OrthoDB" id="10266128at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04178">
        <property type="entry name" value="Nucleostemin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1580.10:FF:000002">
        <property type="entry name" value="Guanine nucleotide-binding protein-like 3 (nucleolar)-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014813">
        <property type="entry name" value="Gnl3_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF30">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN-LIKE 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08701">
        <property type="entry name" value="GN3L_Grn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="158"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="63"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="478" mass="54253" checksum="080D32910659C445" modified="2005-04-12" version="1" fragment="single">IKEKMKIKKSTSKRMPLGRKYKIEKRVSQHKKKMKKIARKSSFIKGKKGRTKELNIPNLWPFKEQMLNEMNDAKERIKQEREEKKKLIKEMKGNKSMMDVNETQNPNVSKLPANLSDFVESALNRQNAFEASKSELEELNMKTLGDPTSSDSSRKAFLRDLRKLIEESDVVLEILDARDPLGFRNVELERSIIAQGKKLVLILSKIDLVPGDVVKEWLTYLRREHPTLAFKSALNSSTEFGVNHSKSSGLNASHDFIKASSVAFGVSPLMSLIKNYSRYNKNSKKSITIGVMGYPNVGKSSLINSLKRGYCVKVGAVAGVTRHLQRIDLDSTTKLIDSPGVVFTGNSQDPSQVLRNTVQLTNVKDYFEPISLLLQKIDHEILLKLYKIPIFNNVSEFLTNVSISRGKLNKGGIPDINSAAMIVLTDWFNGKISYYNFPPQDHSHQNQLEKESITIVSNWSQEFNIDSIYDELDSQIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPX3</accession>
    <name>Q5CPX3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNAj-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625506.1">
        <property type="nucleotide sequence ID" value="XM_625506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPX3"/>
    <dbReference type="STRING" id="353152.Q5CPX3"/>
    <dbReference type="GeneID" id="3372473"/>
    <dbReference type="KEGG" id="cpv:cgd8_450"/>
    <dbReference type="InParanoid" id="Q5CPX3"/>
    <dbReference type="OMA" id="EIVNKAW"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042858">
        <property type="entry name" value="DNAJC8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606:SF4">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15606">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 8/LIPOPOLYSACCHARIDE SPECIFIC RESPONSE-7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="125"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="306" mass="36228" checksum="532633867C28DECC" modified="2005-04-12" version="1" fragment="single">LHFVRELQERKSVKMEGSEGGENGTAEFDPKSYEEKSRDQKTKNTQSEDDLFDLFMKEVNEANSKSTNQGKNIGRNNHSKRVKISKLLIEGKIKEAISSSYGNDELTIGTSEEEILRLTSRVFANAYEVIGIPVDSDDSVIGKKYRKLSLLIHPDKTSHEKAREAFEILNKAYEELQKAENRVKYKEVWKRAEELVKKENKKNKLFKKDQQDQETYKKEFNKQVIEMCEKLLNDLQERKEYSEKCLLANHRFEQELYRQKLQEEKERCVQRQKWNEKFEERAQGWRSYKQNNSKLFNNKSSFDNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQE0</accession>
    <name>Q5CQE0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_1110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625708.1">
        <property type="nucleotide sequence ID" value="XM_625708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQE0"/>
    <dbReference type="STRING" id="353152.Q5CQE0"/>
    <dbReference type="GeneID" id="3372677"/>
    <dbReference type="KEGG" id="cpv:cgd4_1110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1110"/>
    <dbReference type="InParanoid" id="Q5CQE0"/>
    <dbReference type="OrthoDB" id="364262at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="151"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="1001"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="773"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="966"/>
            <end position="987"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1159" mass="127954" checksum="DBE786A58FBDA89C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQF1</accession>
    <name>Q5CQF1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 13">Phosphomannomutase</fullName>
            <ecNumber evidence="5 13">5.4.2.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd4_960</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>alpha-D-mannose 1-phosphate = D-mannose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11140"/>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
            <dbReference type="ChEBI" id="CHEBI:58735"/>
            <dbReference type="EC" id="5.4.2.8"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 13">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; alpha-D-mannose 1-phosphate from D-fructose 6-phosphate: step 2/2.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 13">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the eukaryotic PMM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.8" evidence="5 13"/>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625697.1">
        <property type="nucleotide sequence ID" value="XM_625697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQF1"/>
    <dbReference type="FunCoup" id="Q5CQF1">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQF1"/>
    <dbReference type="GeneID" id="3372684"/>
    <dbReference type="KEGG" id="cpv:cgd4_960"/>
    <dbReference type="InParanoid" id="Q5CQF1"/>
    <dbReference type="OMA" id="ISHRVYT"/>
    <dbReference type="OrthoDB" id="10264771at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00424"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004615">
        <property type="term" value="F:phosphomannomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006013">
        <property type="term" value="P:mannose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02585">
        <property type="entry name" value="HAD_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1240.20:FF:000001">
        <property type="entry name" value="Phosphomannomutase"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha-phosphomannomutase"/>
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        <property type="entry name" value="C2.B.3:_Phosphomannomutase_Lik"/>
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    </dbReference>
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    </dbReference>
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        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="22"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
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        <location>
            <position position="131"/>
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        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
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        </ligand>
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        <location>
            <position position="142"/>
        </location>
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            <name>alpha-D-mannose 1-phosphate</name>
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        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="149"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
    </feature>
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        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>alpha-D-mannose 1-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
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    <feature type="binding site" evidence="11">
        <location>
            <position position="189"/>
        </location>
        <ligand>
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            <dbReference type="ChEBI" id="CHEBI:58409"/>
        </ligand>
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        <location>
            <position position="216"/>
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        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
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        <location>
            <position position="228"/>
        </location>
        <ligand>
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            <position position="230"/>
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        <ligand>
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        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00004699"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00009736"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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            <dbReference type="ARBA" id="ARBA00012730"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
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        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PIRSR" id="PIRSR605002-1"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU361118"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAK87737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="252" mass="29126" checksum="840B12BB3864B963" modified="2005-04-12" version="1" fragment="single">KLSLHTKNNQMDSKKLFLFDLDGTLTLPRKPIMEDMVMTLKNAKSKVKIGVVSGSDYSKICEQLQNNELACSHYIFSENGVVFHDEGVKVSSESISKHLGEDNIKRFVNFCLRYIADLDIPIKRGTFIEYRTGMLNISPIGRNCSYDERLEFFELDKKNGIREKFIQDLSKEFSDLDLQYSIGGQISIDVFPQGWDKRYCLRHVENKFDEIHFFGDKTYPGGNDHEIYNDKRVIGHNVINPNDTIQQLSRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQF2</accession>
    <name>Q5CQF2_CRYPI</name>
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        <submittedName>
            <fullName evidence="6">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
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            <taxon>Sar</taxon>
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            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="OrthoDB" id="538223at2759"/>
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        <property type="component" value="Chromosome 4"/>
    </dbReference>
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        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="C:nucleotide-excision repair complex"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:protein polyubiquitination"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
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        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Rad28/ERCC8/Ckn1/ATCSA-1"/>
    </dbReference>
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        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
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        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
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    </dbReference>
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        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-8"/>
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    </dbReference>
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        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
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        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
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        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="165"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="262"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="409"/>
            <end position="441"/>
        </location>
    </feature>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="551" mass="63013" checksum="4AC92AF431589D43" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQJ3</accession>
    <name>Q5CQJ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625655.1">
        <property type="nucleotide sequence ID" value="XM_625655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQJ3"/>
    <dbReference type="GeneID" id="3372729"/>
    <dbReference type="KEGG" id="cpv:cgd4_490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_490"/>
    <dbReference type="InParanoid" id="Q5CQJ3"/>
    <dbReference type="OMA" id="CTEITAQ"/>
    <dbReference type="OrthoDB" id="343102at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="472"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="588"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="730"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="953"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1131"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="737"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1143"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1169"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1187" mass="126074" checksum="CF2B6942BD57B3CA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQV7</accession>
    <name>Q5CQV7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">10 transmembrane domain protein, possible translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_3110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625895.1">
        <property type="nucleotide sequence ID" value="XM_625895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQV7"/>
    <dbReference type="STRING" id="353152.Q5CQV7"/>
    <dbReference type="GeneID" id="3372789"/>
    <dbReference type="KEGG" id="cpv:cgd4_3110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3110"/>
    <dbReference type="InParanoid" id="Q5CQV7"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="80"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="302"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="401"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="456"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="243"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="713"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="155"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="736" mass="81594" checksum="BB22185F9F3A88EF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQW1</accession>
    <name>Q5CQW1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_3070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625891.1">
        <property type="nucleotide sequence ID" value="XM_625891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQW1"/>
    <dbReference type="GeneID" id="3372793"/>
    <dbReference type="KEGG" id="cpv:cgd4_3070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3070"/>
    <dbReference type="InParanoid" id="Q5CQW1"/>
    <dbReference type="OrthoDB" id="343934at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="142" mass="15950" checksum="4BDB5254E8FFC13F" modified="2005-04-12" version="1">MKEVNDMPLKYVIGMLLGVFFGIWILSICFKGETKKQTQKKNTRRQSAKSATSTKEKLASLNSKEDTVVTRRTTRSSTKQKTPSRKVTSETTQSKEVKPKQTSYNAAPARRTTRNSSKTSNEKPAETSTGKRRVTRSSSKMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR20</accession>
    <name>Q5CR20_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625832.1">
        <property type="nucleotide sequence ID" value="XM_625832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR20"/>
    <dbReference type="GeneID" id="3372881"/>
    <dbReference type="KEGG" id="cpv:cgd4_2440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2440"/>
    <dbReference type="InParanoid" id="Q5CR20"/>
    <dbReference type="OrthoDB" id="343996at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254138" evidence="2">
        <location>
            <begin position="23"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="195" mass="22251" checksum="9A6E02A23BE61F01" modified="2005-04-12" version="1">MQFLNLKIFFVIIVHFISFSIGEQQPSPNEFLQYFSIAAGINSLIFSLSNTIYSIKSLNKLKKKNRGFNEGINESINRSKEHKFKKQITNDQANSLISTEKSYLSNEELDVNQMNFTQLIIQSSKLADIYMVKDNSFIGQSNNTDSELNVSKSIIEYSGNPCFPPNNSKIENTNNTNAQNIDFNINKKFRGLIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR26</accession>
    <name>Q5CR26_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative SAND family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625826.1">
        <property type="nucleotide sequence ID" value="XM_625826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR26"/>
    <dbReference type="SMR" id="Q5CR26"/>
    <dbReference type="STRING" id="353152.Q5CR26"/>
    <dbReference type="GeneID" id="3372886"/>
    <dbReference type="KEGG" id="cpv:cgd4_2380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2380"/>
    <dbReference type="InParanoid" id="Q5CR26"/>
    <dbReference type="OMA" id="FVIDIWR"/>
    <dbReference type="OrthoDB" id="272411at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043972">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043971">
        <property type="entry name" value="FUZ/MON1/HPS1_longin_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004353">
        <property type="entry name" value="Mon1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027">
        <property type="entry name" value="SAND PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13027:SF7">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN MON1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19036">
        <property type="entry name" value="Fuz_longin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19037">
        <property type="entry name" value="Fuz_longin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01546">
        <property type="entry name" value="YEAST73DUF"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FUZ/MON1/HPS1 first Longin" evidence="1">
        <location>
            <begin position="14"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="FUZ/MON1/HPS1 second Longin" evidence="2">
        <location>
            <begin position="228"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF19036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF19037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="471" mass="54414" checksum="0E9D39410CF526F3" modified="2005-04-12" version="1">MFMMPVDNNEKFRKLLIFTSAGKPIYSYGITDQEVFSLFSSALTAMFSKISFVMSKKVYINENDEHTQILDYLKWMSSESHVIVVLERKNIILCCISPFPSDTVRFLKGLLEHVYYQVVMMLTGSIHKILDSRPNFDIQQMLSNSDINIIDQCANSAQINLDSVYCFYNFNKSSKMIKLQGQSNKIEYSSPIIPKILYIESQPLEYRYRKEINKIISGIKMEEILGGILFESKKLVSWFGSKYIKNLPSTDFSLLKNITSIFLNKKTLSNEFWIPICLPAISTVSYVYCYIQCWPLVDEFSNSTSNTCFVLLSSSGDTKVFEKCSAHSKNCRKALLETGYYKILESSKINSFNLSKLMNENCYIKAEIFHLVYVSIAKNSYIISEAHPEIHDLKKIFQMYYNLIETAHTQTRMQNGSSITIILNTKKFKYLIVTTQEFHILSTLPSNSKLDEINLISIINNLRKNVKHFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRD2</accession>
    <name>Q5CRD2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626254.1">
        <property type="nucleotide sequence ID" value="XM_626254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRD2"/>
    <dbReference type="STRING" id="353152.Q5CRD2"/>
    <dbReference type="GeneID" id="3373046"/>
    <dbReference type="KEGG" id="cpv:cgd5_3280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3280"/>
    <dbReference type="InParanoid" id="Q5CRD2"/>
    <dbReference type="OMA" id="QNTCGSN"/>
    <dbReference type="OrthoDB" id="344036at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004860">
        <property type="term" value="F:protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009548">
        <property type="entry name" value="Prkrip1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13507:SF0">
        <property type="entry name" value="PRKR-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06658">
        <property type="entry name" value="DUF1168"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="136" mass="16262" checksum="BA06F1235CFA742E" modified="2005-04-12" version="1">MNSKIESLNNLDTEVVLLSTGKKVEVQKTKVKNEQEEDSFDDKETFERIRNVGSCSSAAGSNFFHSYRKIKQIEEERLNKMEEEYLEEKEKREFSMQRESRIMRYIESTSKKSEKRKKKKMQKVLKKQKNLNNKNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRG6</accession>
    <name>Q5CRG6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626220.1">
        <property type="nucleotide sequence ID" value="XM_626220.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373235"/>
    <dbReference type="KEGG" id="cpv:cgd5_2840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2840"/>
    <dbReference type="InParanoid" id="Q5CRG6"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2045"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2108"/>
            <end position="2131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2143"/>
            <end position="2172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1232"/>
            <end position="1274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1447"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2378"/>
            <end position="2410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="358"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="439"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1244"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1447"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1460"/>
            <end position="1470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2391"/>
            <end position="2403"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2645" mass="303352" checksum="B951D59F91C239EE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRH2</accession>
    <name>Q5CRH2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">40S ribosomal protein S10</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_2780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic ribosomal protein eS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626214.1">
        <property type="nucleotide sequence ID" value="XM_626214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRH2"/>
    <dbReference type="FunCoup" id="Q5CRH2">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRH2"/>
    <dbReference type="GeneID" id="3373229"/>
    <dbReference type="KEGG" id="cpv:cgd5_2780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2780"/>
    <dbReference type="InParanoid" id="Q5CRH2"/>
    <dbReference type="OMA" id="RHYYFYL"/>
    <dbReference type="OrthoDB" id="5211809at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000025">
        <property type="entry name" value="40S ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005326">
        <property type="entry name" value="Plectin_eS10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037447">
        <property type="entry name" value="Ribosomal_eS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12146:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03501">
        <property type="entry name" value="S10_plectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Plectin/eS10 N-terminal" evidence="7">
        <location>
            <begin position="14"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="101"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="128" mass="14750" checksum="EF364BC59A62DD1B" modified="2005-04-12" version="1">MSSHAVCGSRASLVSKKNQRAIYSYLFKEGAIVVHKNPNDPRHSELDIPNLQVMLTMRSLLSKEVVTEKFTWQHNYYLLTDEGVEYLRRYLDLPASVFPATHTKKTMDRPGRSEGNQGRGYGRNRQQH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRH4</accession>
    <name>Q5CRH4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626212.1">
        <property type="nucleotide sequence ID" value="XM_626212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRH4"/>
    <dbReference type="GeneID" id="3373228"/>
    <dbReference type="KEGG" id="cpv:cgd5_2760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2760"/>
    <dbReference type="InParanoid" id="Q5CRH4"/>
    <dbReference type="OMA" id="HANTNVE"/>
    <dbReference type="OrthoDB" id="342895at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="112"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="296" mass="33463" checksum="EF3755EDC5229458" modified="2005-04-12" version="1">MEEETSIRAAEEKAIKEAEFIAASESIKLAQELSLRLEISEPNSKSSSRSPSISAIKEVNDNNEQSGSQPEEIDEENNNKNENPVENESKSIEDEKVEEEQDKIAEEDDENKEIVENEKTLSREEIISQTPSNTQEPIIETREDDSIASQPSKQESKLILSEFRDDSMSFKEEQQETNGHLEDAEVTILQESEEQDVENNGHSNDEILLLNNQEPFEIHGCGHKLNEFSESAKSSITGIFDGCKNNSNSMNTQLKKSAWEYFDSLHSKLINLAGFHNPDECSICKDFKHQDVPLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRL1</accession>
    <name>Q5CRL1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Unchacterized apicomplexan-specific serine rich low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626175.1">
        <property type="nucleotide sequence ID" value="XM_626175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRL1"/>
    <dbReference type="GeneID" id="3373145"/>
    <dbReference type="KEGG" id="cpv:cgd5_2380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2380"/>
    <dbReference type="InParanoid" id="Q5CRL1"/>
    <dbReference type="OMA" id="DEQGFTK"/>
    <dbReference type="OrthoDB" id="74703at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="81"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="361" mass="40251" checksum="C03C613EA0BC51E4" modified="2005-04-12" version="1">MDDSAMGLNAGVSGRKRRLSSDDEETPIKQLEVSIKENADVSSRESTPQIMVNKSTRSKRVLSSDSSDGCKSSGDESEESASNFQSQPSNYTTSEDESDNKSSDNESDDESDSSLSTRGRRKLVKTENGTPVISKQIKSENKQKKGTSTSKKASTKSKSNVGSKTKSKAKGNTGNKTKSVVKKKRVSVEKDPNSQDCSSDEEENTAYVPRRDRDHKQILVAAILCRWWHALPDWPPPDTDYQALLKERNLRLVSIDDWEEAPDVDEDGFSKVYQLSEYIGVFRDSKGNAHDLRPKENKPCYSNLIKMEESKLYELLVTALESQIKTLEADSPGDSKLINELKVELIEAQALLSRRTSNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRN5</accession>
    <name>Q5CRN5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RWD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626151.1">
        <property type="nucleotide sequence ID" value="XM_626151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRN5"/>
    <dbReference type="STRING" id="353152.Q5CRN5"/>
    <dbReference type="GeneID" id="3373116"/>
    <dbReference type="KEGG" id="cpv:cgd5_2120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2120"/>
    <dbReference type="InParanoid" id="Q5CRN5"/>
    <dbReference type="OMA" id="SHIGEIC"/>
    <dbReference type="OrthoDB" id="277175at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006575">
        <property type="entry name" value="RWD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05773">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50908">
        <property type="entry name" value="RWD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RWD" evidence="1">
        <location>
            <begin position="6"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="267" mass="30947" checksum="BEB2B63064683F0F" modified="2005-04-12" version="1">MDDLNLELEALQAIYSDKELSIETKENCQIINIQLIKEANYEINPTSEKNESIKFIKIKVAFLINQGYPEKSPPEINNINICILDGKYSMNECPIDNYHDEESDDNRILFDDSTCIYINTDEIINYYDSLKESYIGRVCLFDIIENLQVFIDDITSKLISNQEFQVEDTNIGLDSIGKDDDDDDDDDEVVYSGLTERILCPIEERVSEEQFNLWKMAFKSEMIEKKIWKDENQDSSQLTGKQLFEKDESLIKSDENSSAIIESTYLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRY4</accession>
    <name>Q5CRY4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_1010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626052.1">
        <property type="nucleotide sequence ID" value="XM_626052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRY4"/>
    <dbReference type="GeneID" id="3373079"/>
    <dbReference type="KEGG" id="cpv:cgd5_1010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1010"/>
    <dbReference type="InParanoid" id="Q5CRY4"/>
    <dbReference type="OMA" id="NEHRITN"/>
    <dbReference type="OrthoDB" id="338988at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="771" mass="86732" checksum="914372D39F97FE6E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS50</accession>
    <name>Q5CS50_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625986.1">
        <property type="nucleotide sequence ID" value="XM_625986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS50"/>
    <dbReference type="GeneID" id="3373193"/>
    <dbReference type="KEGG" id="cpv:cgd5_220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_220"/>
    <dbReference type="InParanoid" id="Q5CS50"/>
    <dbReference type="OrthoDB" id="344243at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="500"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="641"/>
            <end position="856"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="273"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="458"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="504"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="564"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="641"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="679"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="710"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="741"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="789"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="811"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="833"/>
            <end position="845"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="856" mass="97341" checksum="9F49BB8042776EF5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS51</accession>
    <name>Q5CS51_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625985.1">
        <property type="nucleotide sequence ID" value="XM_625985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS51"/>
    <dbReference type="GeneID" id="3373194"/>
    <dbReference type="KEGG" id="cpv:cgd5_210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_210"/>
    <dbReference type="InParanoid" id="Q5CS51"/>
    <dbReference type="OMA" id="IGINIRI"/>
    <dbReference type="OrthoDB" id="341482at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="104"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="591"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="921"/>
            <end position="951"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1085" mass="126909" checksum="03CF6B4005149371" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS74</accession>
    <name>Q5CS74_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628193.1">
        <property type="nucleotide sequence ID" value="XM_628193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS74"/>
    <dbReference type="GeneID" id="3371730"/>
    <dbReference type="KEGG" id="cpv:cgd1_3820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3820"/>
    <dbReference type="InParanoid" id="Q5CS74"/>
    <dbReference type="OMA" id="YENEYRR"/>
    <dbReference type="OrthoDB" id="337826at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="963"/>
            <end position="986"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="995" mass="113729" checksum="43462D50CE665398" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS89</accession>
    <name>Q5CS89_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PITH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_3660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628178.1">
        <property type="nucleotide sequence ID" value="XM_628178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS89"/>
    <dbReference type="FunCoup" id="Q5CS89">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="GeneID" id="3371521"/>
    <dbReference type="KEGG" id="cpv:cgd1_3660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3660"/>
    <dbReference type="InParanoid" id="Q5CS89"/>
    <dbReference type="OMA" id="RLVFKPW"/>
    <dbReference type="OrthoDB" id="2635at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF1">
        <property type="entry name" value="PITH DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="13"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="205" mass="23009" checksum="06CEC5A3797A089C" modified="2005-04-12" version="1">MPGEHGGAGCSCQHEAVITSGKDLLSEIELDKVMALNELNVGSCRGIFRPYEDRLSEDKVCKSQDDDPELIIFVRFSSPCTIHSINIIGGENGKSPNRMNLYINDENLDFSTISDQEPVQSLDLVEDYCGTVDYALKVSRFKNVNLLVMHFPSSFTNDQSWIYYIRIVGESSGYQRKAVQAVYESKPNVSDHKSNIESLNHFSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSA4</accession>
    <name>Q5CSA4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TSP1 domain-containing protein TSP3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_3510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628163.1">
        <property type="nucleotide sequence ID" value="XM_628163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSA4"/>
    <dbReference type="GeneID" id="3371580"/>
    <dbReference type="KEGG" id="cpv:cgd1_3510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3510"/>
    <dbReference type="InParanoid" id="Q5CSA4"/>
    <dbReference type="OMA" id="SETADCN"/>
    <dbReference type="OrthoDB" id="347314at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039942">
        <property type="entry name" value="SBSPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920">
        <property type="entry name" value="RPE-SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920:SF5">
        <property type="entry name" value="SMB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254906" evidence="1">
        <location>
            <begin position="23"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="2">
        <location>
            <begin position="23"/>
            <end position="107"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="507" mass="55753" checksum="7A55BCA7A1665F50" modified="2007-04-03" version="1">MKTFLRILILLVVSIFSGFVNCCPEYGVYYKGTFCAAANGLEWWGASSWQECRERCRSNLFSLIPCKVFAWDSNGGTCTLQNGDRNCKTNSATVISGNPNVAVTGSCATTCTVSSWSSWSSTCVPKVYGGITYRTRKIASKPKHPLERCPHLQEVVNCSDRNWGKMGSSELNDENSALNHVLSGIINQSALGKDTSATNCPNYDVGILGWGCNLDDDLNYGNLFKTETYTWQDCLNRCKQRSDCTHFNFRYTGTGTSPCYLILGEIGCSFHSIGWISGSRDLAVKYGECDINCVLGDWTQWSGCDSALCSDGKAYSKRTRPILTSPRGSGAPCPKTRELKECTSSYTCMSNSCVVGQWSPWSPCSENCTIAVRRRTVQQIPSPGGTPCPHLFEINPVSKCQANPSSILNLANQLSCSTADIFPWGSWSECSSTCGGGFKIRSRNSGFFKYSAESCNNQQCSVYNVEECKISNDSSIIYSQFNRLCLITGYSNSEDRLKLLVNYGLNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSB8</accession>
    <name>Q5CSB8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628149.1">
        <property type="nucleotide sequence ID" value="XM_628149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSB8"/>
    <dbReference type="GeneID" id="3371582"/>
    <dbReference type="KEGG" id="cpv:cgd1_3350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3350"/>
    <dbReference type="InParanoid" id="Q5CSB8"/>
    <dbReference type="OMA" id="MDDTESM"/>
    <dbReference type="OrthoDB" id="342588at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="52"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="172" mass="20920" checksum="0E7CB285EA73BCEF" modified="2005-04-12" version="1">MNDNENIENLVGLLKKVERKQRREEFEKYRKASDEIQHELKQYLVKFHQIAKKSEKKALEQINNEYKQEERRIEESLEQIKDIEVQFNKINSEYEKGKKNLQSRISKLKEMYSTQLELIQEEERKELRILRKEMKNLLLLTKKEAYQFSKNNIKFGNMKIINLIKRISSDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSD8</accession>
    <name>Q5CSD8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Conserved eukaryotic nuclear protein that shares a domain with yeast Lcp5p, a component of the U3 small nucleolar ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_3130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628129.1">
        <property type="nucleotide sequence ID" value="XM_628129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSD8"/>
    <dbReference type="FunCoup" id="Q5CSD8">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSD8"/>
    <dbReference type="GeneID" id="3371468"/>
    <dbReference type="KEGG" id="cpv:cgd1_3130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3130"/>
    <dbReference type="InParanoid" id="Q5CSD8"/>
    <dbReference type="OMA" id="KSMKPVW"/>
    <dbReference type="OrthoDB" id="203440at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007146">
        <property type="entry name" value="Sas10/Utp3/C1D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018972">
        <property type="entry name" value="Sas10_C_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237:SF9">
        <property type="entry name" value="NEUROGUIDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13237">
        <property type="entry name" value="SOMETHING ABOUT SILENCING PROTEIN 10-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09368">
        <property type="entry name" value="Sas10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04000">
        <property type="entry name" value="Sas10_Utp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sas10 C-terminal" evidence="4">
        <location>
            <begin position="620"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="646"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="377"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="68"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="322"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="647"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="692" mass="79535" checksum="20B1181F8C33DC2A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSK0</accession>
    <name>Q5CSK0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628067.1">
        <property type="nucleotide sequence ID" value="XM_628067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSK0"/>
    <dbReference type="GeneID" id="3371727"/>
    <dbReference type="KEGG" id="cpv:cgd1_2380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2380"/>
    <dbReference type="InParanoid" id="Q5CSK0"/>
    <dbReference type="OMA" id="AMIYKEL"/>
    <dbReference type="OrthoDB" id="361494at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="562" mass="65299" checksum="E57585E17224415A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSQ5</accession>
    <name>Q5CSQ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA (Gm18) ribose methylase trm3p SpoU superfamily-SPOUT methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_1720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628012.1">
        <property type="nucleotide sequence ID" value="XM_628012.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSQ5"/>
    <dbReference type="GeneID" id="3371635"/>
    <dbReference type="KEGG" id="cpv:cgd1_1720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1720"/>
    <dbReference type="InParanoid" id="Q5CSQ5"/>
    <dbReference type="OMA" id="DEINDMA"/>
    <dbReference type="OrthoDB" id="241340at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016423">
        <property type="term" value="F:tRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18091">
        <property type="entry name" value="SpoU-like_TRM3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045330">
        <property type="entry name" value="TRM3/TARBP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044748">
        <property type="entry name" value="Trm3/TARBP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029:SF11">
        <property type="entry name" value="METHYLTRANSFERASE TARBP1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12029">
        <property type="entry name" value="RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="3">
        <location>
            <begin position="1654"/>
            <end position="1795"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1808" mass="212306" checksum="55095660ED3454F0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSQ7</accession>
    <name>Q5CSQ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GATA type DNA binding domain fused to an AT hook</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628010.1">
        <property type="nucleotide sequence ID" value="XM_628010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSQ7"/>
    <dbReference type="STRING" id="353152.Q5CSQ7"/>
    <dbReference type="GeneID" id="3371638"/>
    <dbReference type="KEGG" id="cpv:cgd1_1700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1700"/>
    <dbReference type="InParanoid" id="Q5CSQ7"/>
    <dbReference type="OMA" id="THINNKM"/>
    <dbReference type="OrthoDB" id="338008at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000679">
        <property type="entry name" value="Znf_GATA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00401">
        <property type="entry name" value="ZnF_GATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATA-type" evidence="1">
        <location>
            <begin position="146"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="776" mass="85430" checksum="50276E1FBFD7F4AA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSR0</accession>
    <name>Q5CSR0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bystin/ S.cerevisiae En1p like adaptor domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_1670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the bystin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628007.1">
        <property type="nucleotide sequence ID" value="XM_628007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSR0"/>
    <dbReference type="FunCoup" id="Q5CSR0">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSR0"/>
    <dbReference type="GeneID" id="3371641"/>
    <dbReference type="KEGG" id="cpv:cgd1_1670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1670"/>
    <dbReference type="InParanoid" id="Q5CSR0"/>
    <dbReference type="OMA" id="NKYTTGK"/>
    <dbReference type="OrthoDB" id="2192561at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007955">
        <property type="entry name" value="Bystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12821:SF0">
        <property type="entry name" value="BYSTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05291">
        <property type="entry name" value="Bystin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="461" mass="53183" checksum="C8038A22CC3CDAD1" modified="2005-04-12" version="1">MPKFKKSKNKPSRNRNPLHVDIESASCPYSKPRKIKPIDSSHDSLYDNLSNEEQFSSEVPKNIGKKILNEANRQLNDFYDDEIQEHIIYEETNESEEKSNLPIDSAGFIYIDESGIGTADDMGLDNSYWNDLLKNYENENHSSQSIRNQTGFIDTIVSKLREKSSDRKPLEISESCQNSNIPEKVTQVYTLIGEWLTKYKSGKLPKAFSIIPKLENWEEVVFLTNPHNWSPNAMNEAVRIFSSNLSPKDSLKFYSKILYPTIRTNISQNYGKLNYHYYQALKKAMFKPAAWFKGILLPLAEDESCTIKEAIIIGSVLSKVSIPVLHTAAAIIKLSQIKVWNTCQTHFIMVLLCKKYSMPKKVIDELVDNFTKFDQKFLHYNDSSPLFSQNNINLNSTNVQTNSILPVTWHKTLLVFVQRYKYEFSSDQINRLNDLVKNQYHYLISPEIIRELSHSLIKVPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSS2</accession>
    <name>Q5CSS2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Non-canonical E2 ubiquitin-conjugating enzyme C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627995.1">
        <property type="nucleotide sequence ID" value="XM_627995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSS2"/>
    <dbReference type="GeneID" id="3371636"/>
    <dbReference type="KEGG" id="cpv:cgd1_1550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1550"/>
    <dbReference type="InParanoid" id="Q5CSS2"/>
    <dbReference type="OMA" id="DAFAHMF"/>
    <dbReference type="OrthoDB" id="406045at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018553">
        <property type="entry name" value="E2_Ub-conjug_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057668">
        <property type="entry name" value="E2_Ub-conjug_enz_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560">
        <property type="entry name" value="UPF0652 PROTEIN C16A11.03C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31560:SF0">
        <property type="entry name" value="UPF0652 PROTEIN C22H10.08"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09418">
        <property type="entry name" value="DUF2009"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Non-canonical E2 ubiquitin-conjugating enzyme C-terminal" evidence="1">
        <location>
            <begin position="136"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="domain" description="Non-canonical E2 ubiquitin-conjugating enzyme C-terminal" evidence="1">
        <location>
            <begin position="363"/>
            <end position="646"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="648" mass="74430" checksum="BB0BF3813C7AD4B9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSU4</accession>
    <name>Q5CSU4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apicomplexa specific secreted protein Pf (23508265), signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627973.1">
        <property type="nucleotide sequence ID" value="XM_627973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSU4"/>
    <dbReference type="GeneID" id="3371591"/>
    <dbReference type="KEGG" id="cpv:cgd1_1290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1290"/>
    <dbReference type="InParanoid" id="Q5CSU4"/>
    <dbReference type="OMA" id="YMLMKDD"/>
    <dbReference type="OrthoDB" id="415865at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="266" mass="29545" checksum="5F43F92E38BDFEB5" modified="2005-04-12" version="1">MGSSKIRTAAAVAGGVAVVGALLYYLFRSDSSENKDESNTLVEASATKDVPENTVKGSLDTFTKEDMLLLLDEILESQNSLKKIMRSLTNDFVADPPKSLQDCYNKVKDASPQDPLDKRKISLVDFDRLVERFYNDEGISSAIEKIMGIHGPSSITERAGSISSDQLVKVNEFMLKELREFVDQYIFIANKDQFDVKTLTIAAQVWVGSKVEKQFNLSSDDIETAMLLHSQTLRNDPDFGRISFQMQATMEQLLGSPAPTNLPFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSW5</accession>
    <name>Q5CSW5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_1070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627952.1">
        <property type="nucleotide sequence ID" value="XM_627952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSW5"/>
    <dbReference type="FunCoup" id="Q5CSW5">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSW5"/>
    <dbReference type="GeneID" id="3371368"/>
    <dbReference type="KEGG" id="cpv:cgd1_1070"/>
    <dbReference type="InParanoid" id="Q5CSW5"/>
    <dbReference type="OMA" id="YVPSKKF"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12383">
        <property type="entry name" value="RRM_RBM42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050825">
        <property type="entry name" value="RBM42_RBP45_47-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034215">
        <property type="entry name" value="RBM42_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640:SF11">
        <property type="entry name" value="RNA-BINDING PROTEIN 42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47640">
        <property type="entry name" value="TRNA SELENOCYSTEINE 1-ASSOCIATED PROTEIN 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="41"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="164" mass="19539" checksum="7E32593A1041B861" modified="2005-04-12" version="1" fragment="single">EMNIEKEDKSILDSHSKKRFRKAAGQVWVDNTLDEWPENDFRLFCGDLGNDVTEEILANAFKKYASFEKCKVIRNKHTGKSRGYGFVSFTNPNDMLNAMKEMNRKYVGSRPITLKRSKWKDREIDSDKNKRFDEMTRRNESANALVQDYQKEYKKRKYSDKFQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT23</accession>
    <name>Q5CT23_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd1_340</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627894.1">
        <property type="nucleotide sequence ID" value="XM_627894.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT23"/>
    <dbReference type="FunCoup" id="Q5CT23">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT23"/>
    <dbReference type="MEROPS" id="C86.A05"/>
    <dbReference type="GeneID" id="3371418"/>
    <dbReference type="KEGG" id="cpv:cgd1_340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_340"/>
    <dbReference type="InParanoid" id="Q5CT23"/>
    <dbReference type="OMA" id="ICNLEQH"/>
    <dbReference type="OrthoDB" id="10063692at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033865">
        <property type="entry name" value="Ataxin-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006155">
        <property type="entry name" value="Josephin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14159:SF0">
        <property type="entry name" value="ATAXIN-3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02099">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01233">
        <property type="entry name" value="JOSEPHIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01246">
        <property type="entry name" value="Josephin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50957">
        <property type="entry name" value="JOSEPHIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="9" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Josephin" evidence="13">
        <location>
            <begin position="7"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="12">
        <location>
            <begin position="296"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK88518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="397" mass="45527" checksum="79E8B1FCCBBFBC8F" modified="2005-04-12" version="1">MSTKENVIVYWEKQGNDRMCALHCLNSILQGPYFDEAFLSKIAYEIDDMERRLLEKSNSTFKTISDNNSQNASYDGFFSIMVLQECLQRHGYSCIPAANPRVQDYILYPSSCCGYIINSSEHWTSIRCVKGKWFNLDSLKAAPIHIDYFEVSKYLQEIMFSGKSVFVVQKIQNETDSHSIPLPDPDPFLRPIKNNGKQRFYLTASEIENLVLEKQKEENRVSQMGDETPNKNFMYSKKPVEYSWPTSGGNVLQSTLNNVDQSNEMTSEEKELEKVLRESAIEFAKSIPLPDEPPADHVNSIQIRVRSKVGSSFVRRFDKTNSCKHLFSWIEYEMALLGNSIHGSPYSFVSQFPYLKVSKFDENSIKISRSDISEIILNSPTFNDIGINENTLLLLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTA8</accession>
    <name>Q5CTA8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 2-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_3760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. Sedlin subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626561.1">
        <property type="nucleotide sequence ID" value="XM_626561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTA8"/>
    <dbReference type="FunCoup" id="Q5CTA8">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTA8"/>
    <dbReference type="GeneID" id="3373411"/>
    <dbReference type="KEGG" id="cpv:cgd2_3760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3760"/>
    <dbReference type="InParanoid" id="Q5CTA8"/>
    <dbReference type="OMA" id="FHYIVHC"/>
    <dbReference type="OrthoDB" id="10258445at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14854">
        <property type="entry name" value="TRAPPC2L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044760">
        <property type="entry name" value="TRAPPC2L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00024408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="150" mass="17100" checksum="DBCEB11C0EEF5DED" modified="2005-04-12" version="1">MIQVVCISIVDRSNQPLFFRTLENESLDSLHFAVYSALDIIERKASGDAMEGSLDPYLGYLGPAISLSYEYEIYGFLSFSHVKIIVVLQDHPENEIELRNFFHNVYKAYVDSICNPFLLRTIETPKLIGKIDRLISSAREVNIHIDKGQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTC4</accession>
    <name>Q5CTC4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626545.1">
        <property type="nucleotide sequence ID" value="XM_626545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTC4"/>
    <dbReference type="GeneID" id="3373625"/>
    <dbReference type="KEGG" id="cpv:cgd2_3580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3580"/>
    <dbReference type="InParanoid" id="Q5CTC4"/>
    <dbReference type="OMA" id="NTSHVMV"/>
    <dbReference type="OrthoDB" id="343354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="600" mass="67446" checksum="16F7519AB0308AC7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTC5</accession>
    <name>Q5CTC5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">YjbN-like Dus1p tRNA dihydouriding synthase Tim barrel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_3570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626544.1">
        <property type="nucleotide sequence ID" value="XM_626544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTC5"/>
    <dbReference type="STRING" id="353152.Q5CTC5"/>
    <dbReference type="GeneID" id="3373629"/>
    <dbReference type="KEGG" id="cpv:cgd2_3570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3570"/>
    <dbReference type="InParanoid" id="Q5CTC5"/>
    <dbReference type="OMA" id="ACMENTT"/>
    <dbReference type="OrthoDB" id="10262250at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004653">
        <property type="entry name" value="DusA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907">
        <property type="entry name" value="FMN-LINKED OXIDOREDUCTASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42907:SF1">
        <property type="entry name" value="FMN-LINKED OXIDOREDUCTASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="4">
        <location>
            <begin position="30"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="DUS-like FMN-binding" evidence="4">
        <location>
            <begin position="212"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="519" mass="60162" checksum="A150EE9E443B4F49" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTG1</accession>
    <name>Q5CTG1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin fusion degradation (UFD1) family protein, double Psi beta barrel fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_3150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88700.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626508.1">
        <property type="nucleotide sequence ID" value="XM_626508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTG1"/>
    <dbReference type="FunCoup" id="Q5CTG1">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTG1"/>
    <dbReference type="GeneID" id="3373560"/>
    <dbReference type="KEGG" id="cpv:cgd2_3150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3150"/>
    <dbReference type="InParanoid" id="Q5CTG1"/>
    <dbReference type="OMA" id="LIFPTRH"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049439">
        <property type="entry name" value="TRAFD1-XIAF1_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21366">
        <property type="entry name" value="TRAFD1-XIAF1_ZnF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="3">
        <location>
            <begin position="107"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="5">
        <location>
            <begin position="205"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="TRAFD1/XAF1 zinc finger" evidence="4">
        <location>
            <begin position="621"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF21366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88700.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="658" mass="77115" checksum="29CDB852885EFDDB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTN2</accession>
    <name>Q5CTN2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626437.1">
        <property type="nucleotide sequence ID" value="XM_626437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTN2"/>
    <dbReference type="GeneID" id="3373509"/>
    <dbReference type="KEGG" id="cpv:cgd2_2330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2330"/>
    <dbReference type="InParanoid" id="Q5CTN2"/>
    <dbReference type="OrthoDB" id="343287at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="168" mass="19392" checksum="4D59AF1C753628D2" modified="2005-04-12" version="1">MSDHSSLFSLSKISISDLLMLKEKKCENKIENAKFITKPSNLEDIFTEDFKQKMERNKICLSVNAQGDVLTHFPLFLNEPFTSNENNKSLSARIDTKKENLHLNQTNNSAISKKRSKINEIIETNIGDHLIYEMKINKNRFARKELTSTKLIWNSIQENIKSIISSTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTR3</accession>
    <name>Q5CTR3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd2_1990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GOSR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626406.1">
        <property type="nucleotide sequence ID" value="XM_626406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTR3"/>
    <dbReference type="GeneID" id="3373732"/>
    <dbReference type="KEGG" id="cpv:cgd2_1990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1990"/>
    <dbReference type="InParanoid" id="Q5CTR3"/>
    <dbReference type="OMA" id="KQVDQRY"/>
    <dbReference type="OrthoDB" id="339356at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005797">
        <property type="term" value="C:Golgi medial cisterna"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048219">
        <property type="term" value="P:inter-Golgi cisterna vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023601">
        <property type="entry name" value="Golgi_SNAP_su1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094:SF2">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21094">
        <property type="entry name" value="GOS-28 SNARE- RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="215"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="233" mass="27104" checksum="FFF5DD8AB98A40C9" modified="2005-04-12" version="1">MSICLRGIQNALETKLGELDTLKSHDWNLEIDAFLDEEEKGTTKEGGIIMSEHKWEIEVQSLKNDICCLFDSFEKEVDILNNDGMNTDRYSSLLQNLKHDYNNICKYIDSRKKRVNLFSKSNTPSGNKYQKLYIDKSTESFERSQFYREKNIIKDSVLNLNSMIDQAMNTTHSLSGQNHTLKLIFDKTRTMRKKSISNIQSVVNSIINLKKRQNFVVSVLFILFVVIIIYIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTT5</accession>
    <name>Q5CTT5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_1640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626384.1">
        <property type="nucleotide sequence ID" value="XM_626384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTT5"/>
    <dbReference type="FunCoup" id="Q5CTT5">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTT5"/>
    <dbReference type="GeneID" id="3373750"/>
    <dbReference type="KEGG" id="cpv:cgd2_1640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1640"/>
    <dbReference type="InParanoid" id="Q5CTT5"/>
    <dbReference type="OMA" id="LMWSDPI"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF509">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="96"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="141"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="788" mass="90596" checksum="FA0401D3DFF8774C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTY0</accession>
    <name>Q5CTY0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative molybdopterin synthase sulphurylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_1120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626339.1">
        <property type="nucleotide sequence ID" value="XM_626339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTY0"/>
    <dbReference type="STRING" id="353152.Q5CTY0"/>
    <dbReference type="GeneID" id="3373590"/>
    <dbReference type="KEGG" id="cpv:cgd2_1120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1120"/>
    <dbReference type="InParanoid" id="Q5CTY0"/>
    <dbReference type="OMA" id="IPDVGMD"/>
    <dbReference type="OrthoDB" id="10261062at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004792">
        <property type="term" value="F:thiosulfate-cyanide sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042292">
        <property type="term" value="F:URM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00158">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000033">
        <property type="entry name" value="Adenylyltransferase and sulfurtransferase MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001763">
        <property type="entry name" value="Rhodanese-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF102">
        <property type="entry name" value="ADENYLYLTRANSFERASE AND SULFURTRANSFERASE MOCS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00581">
        <property type="entry name" value="Rhodanese"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00450">
        <property type="entry name" value="RHOD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52821">
        <property type="entry name" value="Rhodanese/Cell cycle control phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50206">
        <property type="entry name" value="RHODANESE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="Rhodanese" evidence="5">
        <location>
            <begin position="368"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="495" mass="55006" checksum="B9B57EF3B62807BE" modified="2005-04-12" version="1">MEIIDQNWATFGFYFLSVVICTLSTIVFFLWKSDGEVNTKKDIFETINSPSLSEENVIRYSRQIALKEVGVSGQVKLKNAKVLVIGAGGLGSPILLYLTGAGIGVIGVVDHDTVSTSNLHRQIIHSTDKNHMSKSISAKQSCNSLNPNTRIITYQEALSIDLVKEIFPLYDVIVDATDNCRSRYLINDAAVYYKKPVVSGAALKWQGHVTVYNYSNGPCYRCIAPREDNGKVDGTPGGAEIFGVLGMMVGVIGCLQSTEVIKVILNDFGKGDNSGIDSSNHLPVLSGKMLFYNSLSNEHMVRLVRIRDKNSECKTCGSNPIPFFKAGIDSYKVFKGMEMAKDSFYPIPSSNILSSDNFEEKMNLARKSNIDIKIFDVRPKNLYDISHIKGSKNVLEDDVIKGLASLGVHTNSKTGEIINWPKDKNDQIKQFLVEYFQINENCIILVLCLNGVRSYYISTVIQQCFDKLNMKVSNYYLNGGISSIRSKLLKNFPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU20</accession>
    <name>Q5CU20_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Inward rectifier potassium channel C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd2_630</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626299.1">
        <property type="nucleotide sequence ID" value="XM_626299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU20"/>
    <dbReference type="STRING" id="353152.Q5CU20"/>
    <dbReference type="GeneID" id="3373387"/>
    <dbReference type="KEGG" id="cpv:cgd2_630"/>
    <dbReference type="InParanoid" id="Q5CU20"/>
    <dbReference type="OMA" id="CHAANWM"/>
    <dbReference type="OrthoDB" id="273257at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034702">
        <property type="term" value="C:monoatomic ion channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005242">
        <property type="term" value="F:inward rectifier potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990573">
        <property type="term" value="P:potassium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034765">
        <property type="term" value="P:regulation of monoatomic ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1400">
        <property type="entry name" value="G protein-activated inward rectifier potassium channel 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041647">
        <property type="entry name" value="IRK_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016449">
        <property type="entry name" value="K_chnl_inward-rec_Kir"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013518">
        <property type="entry name" value="K_chnl_inward-rec_Kir_cyto"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040445">
        <property type="entry name" value="Kir_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11767">
        <property type="entry name" value="INWARD RECTIFIER POTASSIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01007">
        <property type="entry name" value="IRK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17655">
        <property type="entry name" value="IRK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8 11" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 11" id="KW-0630">Potassium</keyword>
    <keyword evidence="3 11" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 11" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0851">Voltage-gated channel</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="102"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel inwardly rectifying transmembrane" evidence="13">
        <location>
            <begin position="66"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Inward rectifier potassium channel C-terminal" evidence="14">
        <location>
            <begin position="299"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022882"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF17655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK88883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="17">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="401" mass="45910" checksum="172A2F81F2F9F6BC" modified="2005-04-12" version="1">MNIELSKPLLKTYTQDQMYYNSKKNQISDTSSNQSYESPDLSDRIETKASDFISYSNRNPPNILMENGTLNIMHHWDRLSQFFEFCLHDRFHVMLSMSWGSLILFIFLVYILLAIILAIIHFIITFGDAANCIGSDKFGNIEYFFFAVETMFSIGYGSPRSPCCLITNYFTSITVISGCILNSVTVGIFFTKFSESTSRKWSICFSKELCGIGFKSITPEEVLEVPNQSNLPPITSYAFTKAAETTCENCPFIISFRLFNISQEPFFSPDLKIFILIHGDNGPYITEISSYKLDVPLEFMETPITVSIYSNQPDSPLKNFTINHLRNQGHLIELMILLRFSDNRTSKNLEVRKTWRLNNVFWGYKFSSIIKKQVYHGGTMYKVGISDLDNIEPVISGTPFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU42</accession>
    <name>Q5CU42_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA polymerase</fullName>
            <ecNumber evidence="12">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd3_4290</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18 12">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="12"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626972.1">
        <property type="nucleotide sequence ID" value="XM_626972.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CU42">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU42"/>
    <dbReference type="GeneID" id="3374056"/>
    <dbReference type="KEGG" id="cpv:cgd3_4290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4290"/>
    <dbReference type="InParanoid" id="Q5CU42"/>
    <dbReference type="OMA" id="MTKMNVG"/>
    <dbReference type="OrthoDB" id="6755010at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05776">
        <property type="entry name" value="DNA_polB_alpha_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05532">
        <property type="entry name" value="POLBc_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.10.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3200.20">
        <property type="entry name" value="DNA Polymerase alpha, zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017964">
        <property type="entry name" value="DNA-dir_DNA_pol_B_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024647">
        <property type="entry name" value="DNA_pol_a_cat_su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038256">
        <property type="entry name" value="Pol_alpha_znc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045846">
        <property type="entry name" value="POLBc_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00592">
        <property type="entry name" value="pol2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45861:SF1">
        <property type="entry name" value="DNA POLYMERASE ALPHA CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12254">
        <property type="entry name" value="DNA_pol_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00106">
        <property type="entry name" value="DNAPOLB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00116">
        <property type="entry name" value="DNA_POLYMERASE_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="10 12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 12" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 12" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase alpha catalytic subunit N-terminal" evidence="15">
        <location>
            <begin position="14"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B exonuclease" evidence="14">
        <location>
            <begin position="418"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed DNA polymerase family B multifunctional" evidence="13">
        <location>
            <begin position="779"/>
            <end position="1240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000442"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF03104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF12254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK88942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1488" mass="170137" checksum="55B5D636E0388BFE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU43</accession>
    <name>Q5CU43_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Secreted insulinase like peptidase, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd3_4280</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626971.1">
        <property type="nucleotide sequence ID" value="XM_626971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU43"/>
    <dbReference type="STRING" id="353152.Q5CU43"/>
    <dbReference type="GeneID" id="3374057"/>
    <dbReference type="KEGG" id="cpv:cgd3_4280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4280"/>
    <dbReference type="InParanoid" id="Q5CU43"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="7">
        <location>
            <begin position="124"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="8">
        <location>
            <begin position="290"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1244" mass="146832" checksum="B1B75338EC14DA58" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU58</accession>
    <name>Q5CU58_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_4120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626956.1">
        <property type="nucleotide sequence ID" value="XM_626956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU58"/>
    <dbReference type="GeneID" id="3373895"/>
    <dbReference type="KEGG" id="cpv:cgd3_4120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4120"/>
    <dbReference type="InParanoid" id="Q5CU58"/>
    <dbReference type="OrthoDB" id="336936at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003923">
        <property type="entry name" value="TAF10"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03540">
        <property type="entry name" value="TAF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="111" mass="12750" checksum="580069034ED131B3" modified="2005-04-12" version="1">MTLPGKSANTESDEAKIESIIFPKECVEYIMNRQGAKSSDPNLFSIVSILGQKFIEECLKKSIETTEDGRFVIRDENLRNMIKMENPSCAVNNDFNLFLIPNQRYKELLKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUB8</accession>
    <name>Q5CUB8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_3450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626896.1">
        <property type="nucleotide sequence ID" value="XM_626896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUB8"/>
    <dbReference type="GeneID" id="3374116"/>
    <dbReference type="KEGG" id="cpv:cgd3_3450"/>
    <dbReference type="InParanoid" id="Q5CUB8"/>
    <dbReference type="OrthoDB" id="342344at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="204" mass="23019" checksum="1C5B1B4933C6172A" modified="2005-04-12" version="1">MKRYYKNESSGLSSVLSIPRTNTDFEVETAATKRESREFPSLPSTSIEIDSDEYCNISSASLDSVCIKDLSRLESNSLIKKGDRLKYKTVWMGPGGGYSLMEEYTEPRKCMEREVPKESEMELKRYRQPGSCKNSKSMNNLASNSSVQVIEEAGILKEDSYIFKSSRSLANVDWNKQEFVGPLPFQNKVAIGNRSCLGRNLIPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUG8</accession>
    <name>Q5CUG8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">U2 small nuclear ribonucleoprotein A' like LRR repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_2880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the U2 small nuclear ribonucleoprotein A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626846.1">
        <property type="nucleotide sequence ID" value="XM_626846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUG8"/>
    <dbReference type="FunCoup" id="Q5CUG8">
        <property type="interactions" value="581"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUG8"/>
    <dbReference type="GeneID" id="3373774"/>
    <dbReference type="KEGG" id="cpv:cgd3_2880"/>
    <dbReference type="InParanoid" id="Q5CUG8"/>
    <dbReference type="OMA" id="QPREFPQ"/>
    <dbReference type="OrthoDB" id="433501at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044640">
        <property type="entry name" value="RU2A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10552:SF6">
        <property type="entry name" value="U2 SMALL NUCLEAR RIBONUCLEOPROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14580">
        <property type="entry name" value="LRR_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="257" mass="29421" checksum="64B08ED1E4BC1109" modified="2005-04-12" version="1" fragment="single">TYLLIMDTLLTQLSTIFLNKINESYSFNIRNSKIKAFDNTGILKDQFECIDLSDNSISSLSYISNLNRLSTFIACNNEIEYIESGFTKSLPNLESLVLTNNQIKNIESISAIFFLRNLKRLSLVNNPITKIPNYKTILIGMLPNLIYLDFQKINKVDRNASELFFETNSIGKDLLVQYSFKNFEDNSIKIMNNVSTSKINTIINLPINKPNHTQLNNIKIAISLCNDIKQLRVLEDSLMKSEITPEAQEIVDNYINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUM2</accession>
    <name>Q5CUM2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L37A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_2250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL43 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626792.1">
        <property type="nucleotide sequence ID" value="XM_626792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUM2"/>
    <dbReference type="STRING" id="353152.Q5CUM2"/>
    <dbReference type="GeneID" id="3373781"/>
    <dbReference type="KEGG" id="cpv:cgd3_2250"/>
    <dbReference type="InParanoid" id="Q5CUM2"/>
    <dbReference type="OMA" id="EAMKRTC"/>
    <dbReference type="OrthoDB" id="10258345at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002674">
        <property type="entry name" value="Ribosomal_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050522">
        <property type="entry name" value="Ribosomal_protein_eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00280">
        <property type="entry name" value="eL43_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48129:SF1">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01780">
        <property type="entry name" value="Ribosomal_L37ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="87" mass="9550" checksum="AD1883DB7C1FC072" modified="2005-04-12" version="1" fragment="single">VGIVGKFGTRYGASLRKQVKKTEILQRETYVCPFCGKTATKRTACGIWECKGCRKVLAGGAWQLSTAAAVTARSTIARLRKQREEAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUS7</accession>
    <name>Q5CUS7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626737.1">
        <property type="nucleotide sequence ID" value="XM_626737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUS7"/>
    <dbReference type="GeneID" id="3374018"/>
    <dbReference type="KEGG" id="cpv:cgd3_1640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1640"/>
    <dbReference type="InParanoid" id="Q5CUS7"/>
    <dbReference type="OMA" id="ILCHILA"/>
    <dbReference type="OrthoDB" id="340619at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="325"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="386"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="456" mass="53354" checksum="5FC4E51B48AAA313" modified="2005-04-12" version="1">MENGEKYIQKVGMKEGRVSRTQYLFFQVYNNTKRCCWSISIPRECIALSRILLEYPYSYFLPLLSCFQCIITITVCHIFSAALSHLPYYKLFLPFTYFLTIHSPEKYIYIFGLLFSWVLFVLSIPMLYHLLFYHLPQPLEVWVTPRYSRIGELMANIENSANEFDSEKGSHNYYMEHNQKKMLNKTTNRRNERCPAEDYCTENETFLNVDEYETNNFGSTNLIRVKQGVFHRAIATWNLRITFFSLSLAIFFGFSALIFPFGLNLRRIIFNDIGTSSGTLYYLANALLSISPSNLFAFFTFIHALLISIYVFIYRRPVISRLSRILKMSCSAIMVIIILIRSISTFILSHYYMNKFRSGRLFNDNYPNLNSFLADFNIKMKANHSFYIRMALASSSQYLFLFVTMVFISSYSLDIHQLHLSSINAFKSTEESESYSLIKRGGDFVSNNDEKDSILY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV02</accession>
    <name>Q5CV02_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribonuclease P protein subunit p29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of nuclear RNase P and RNase MRP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
            <location evidence="7">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal RNase P protein component 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626662.1">
        <property type="nucleotide sequence ID" value="XM_626662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV02"/>
    <dbReference type="FunCoup" id="Q5CV02">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV02"/>
    <dbReference type="GeneID" id="3374132"/>
    <dbReference type="KEGG" id="cpv:cgd3_800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_800"/>
    <dbReference type="InParanoid" id="Q5CV02"/>
    <dbReference type="OMA" id="LEICKKW"/>
    <dbReference type="OrthoDB" id="124041at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030677">
        <property type="term" value="C:ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033204">
        <property type="term" value="F:ribonuclease P RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.210">
        <property type="entry name" value="Ribonuclease P/MRP, subunit p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00754">
        <property type="entry name" value="RNase_P_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016848">
        <property type="entry name" value="RNase_P/MRP_Rpp29-subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036980">
        <property type="entry name" value="RNase_P/MRP_Rpp29_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023538">
        <property type="entry name" value="RNP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023534">
        <property type="entry name" value="Rof/RNase_P-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002730">
        <property type="entry name" value="Rpp29/RNP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13348">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01868">
        <property type="entry name" value="RNase_P-MRP_p29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF027081">
        <property type="entry name" value="RNase_P/MRP_p29_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00538">
        <property type="entry name" value="POP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101744">
        <property type="entry name" value="Rof/RNase P subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRNR" id="PIRNR027081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="270" mass="30372" checksum="B90A72A17AE4D5DB" modified="2005-04-12" version="1">MKKSDFENERGHSIYDIFTDQEKVTYFGNGNLNSKTICSSLKDAGLDLKVMRDVENFLGNSGGIDELKQSGHSSSNPKLTGITTSVIRMDKVKEEKKSQDGQDLKKLNHKVFKNEGFFDIAREIKLRKLSYSHFIPLHQLWKQYIKGLTESNSVNSGTNGAIRTRGGIKLSQLSQNLSQADLHGSMISVISSRNISCVNVQGIVVKETKETFVIISADNKVRTILKSQSIFGIVISNNYLVTIYGSQLCYHPCERIKHKFRHRDSLNITP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV09</accession>
    <name>Q5CV09_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Very large probable mucin, 11700 aa long protein with signal peptide and pronounced Thr repeat (308 aa long)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626655.1">
        <property type="nucleotide sequence ID" value="XM_626655.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV09"/>
    <dbReference type="GeneID" id="3374138"/>
    <dbReference type="KEGG" id="cpv:cgd3_720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_720"/>
    <dbReference type="InParanoid" id="Q5CV09"/>
    <dbReference type="OrthoDB" id="342462at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051298">
        <property type="entry name" value="Heme_transport/Cell_adhesion"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22917:SF6">
        <property type="entry name" value="EG:8D8.2 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22917">
        <property type="entry name" value="HEMOPEXIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253882" evidence="2">
        <location>
            <begin position="25"/>
            <end position="11696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4134"/>
            <end position="4157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="5139"/>
            <end position="5163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="5407"/>
            <end position="5431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="6067"/>
            <end position="6102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="6450"/>
            <end position="6473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="6731"/>
            <end position="6800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="10941"/>
            <end position="10974"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="5142"/>
            <end position="5153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="5410"/>
            <end position="5431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="11696" mass="1318829" checksum="88B0652B72A12636" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV11</accession>
    <name>Q5CV11_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd3_690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626653.1">
        <property type="nucleotide sequence ID" value="XM_626653.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV11"/>
    <dbReference type="GeneID" id="3374140"/>
    <dbReference type="KEGG" id="cpv:cgd3_690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_690"/>
    <dbReference type="InParanoid" id="Q5CV11"/>
    <dbReference type="OMA" id="YEVIRIC"/>
    <dbReference type="OrthoDB" id="4865934at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="150"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="869"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="966"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1046"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1070"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1156"/>
            <end position="1178"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="152"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="870"/>
            <end position="1166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1586" mass="180418" checksum="D737AF5F5557B83A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV13</accession>
    <name>Q5CV13_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626651.1">
        <property type="nucleotide sequence ID" value="XM_626651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV13"/>
    <dbReference type="GeneID" id="3374142"/>
    <dbReference type="KEGG" id="cpv:cgd3_660"/>
    <dbReference type="InParanoid" id="Q5CV13"/>
    <dbReference type="OMA" id="FNTEMIP"/>
    <dbReference type="OrthoDB" id="341199at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254535" evidence="2">
        <location>
            <begin position="23"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="882" mass="96839" checksum="329F8262F0B56DCD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV56</accession>
    <name>Q5CV56_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_5350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627413.1">
        <property type="nucleotide sequence ID" value="XM_627413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV56"/>
    <dbReference type="GeneID" id="3374215"/>
    <dbReference type="KEGG" id="cpv:cgd8_5350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5350"/>
    <dbReference type="InParanoid" id="Q5CV56"/>
    <dbReference type="OMA" id="CIVACEE"/>
    <dbReference type="OrthoDB" id="339298at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="812"/>
            <end position="821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="843"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="843" mass="97916" checksum="D2072E9D83458FAF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV64</accession>
    <name>Q5CV64_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Integral membrane protein predicted amino acid permease, 11x transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_5270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the amino acid-polyamine-organocation (APC) superfamily. Polyamine:cation symporter (PHS) (TC 2.A.3.12) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627405.1">
        <property type="nucleotide sequence ID" value="XM_627405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV64"/>
    <dbReference type="STRING" id="353152.Q5CV64"/>
    <dbReference type="GeneID" id="3374226"/>
    <dbReference type="KEGG" id="cpv:cgd8_5270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5270"/>
    <dbReference type="InParanoid" id="Q5CV64"/>
    <dbReference type="OMA" id="FPQDGGY"/>
    <dbReference type="OrthoDB" id="340262at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015203">
        <property type="term" value="F:polyamine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1740.10">
        <property type="entry name" value="Amino acid/polyamine transporter I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002293">
        <property type="entry name" value="AA/rel_permease1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044566">
        <property type="entry name" value="RMV1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45826:SF2">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45826">
        <property type="entry name" value="POLYAMINE TRANSPORTER PUT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13520">
        <property type="entry name" value="AA_permease_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="51"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="164"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="338"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="365"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="433"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="456"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="500" mass="56767" checksum="43CD2C8C0DC35126" modified="2005-04-12" version="1">MESNGVNLNNKEWTKKRWMPWITMVFTSFFTVSGGSYGSEVVLPVIGLRNFTLIQICICIFYAIPLILIYEMLNKSFPPNSGPKSWCESIFDPFLAVFLDVLYIFMEIGMLSSYVGVASAYIHSFSRSLKYGAFSTSGQLSISVIVFLLIIAVSLLLTYFDDYIIWMFSVVVAPLIIMVIFTFYSIPINSWRAIPDLPERSQLDWITGLQYVMWLNCGYERSFSPNSKASKGQLTNDRDFKFCLIANAILVSILYILPLWCGCCILNHFNRDGRSFQLGNFFTFSGFLVGGNFLSSMITISACFSSIGCITSDVGLVSQFLIAQWYRIKNIKNYRSSFLQETLVSLGIVMFCSFLTLLINQEHFAAGASTLYGFITLITVIAYLKFLWTIDSKETFPDSEFPLINNENITKPSHILLLNSLYYSKLPLRIKQIIHSTLAIPAIFFTLVIFFTTSSILYLTIILLALFATPIFVPKYNKDNNIKNIKIESSKKFPGFLNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVC4</accession>
    <name>Q5CVC4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627345.1">
        <property type="nucleotide sequence ID" value="XM_627345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVC4"/>
    <dbReference type="GeneID" id="3374445"/>
    <dbReference type="KEGG" id="cpv:cgd8_4600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4600"/>
    <dbReference type="InParanoid" id="Q5CVC4"/>
    <dbReference type="OrthoDB" id="342441at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="428" mass="50872" checksum="C731632A7CEAF635" modified="2005-04-12" version="1">MIDEDSSYKDLFSLNLMKYYEYMDKIPDKRPFGNTFDDHAKEKDYILIIKLEEIESEIILHLRSTFYNNIKDLSTLENINVISCLKEMVELIKLENFNLHENLRNLAEFSNKNYKQIMENRENSQVQVKVQELEQKQKLEQELIQENEQEQEQEQEQEQEQKQELSQKIEDIYDNVTIQFNSPNTRGTLELSELRVPSYLNNSPLIDKHNNNINIFNSKISNSELLHNQIKTYRFIKDSSKTGNHQYYGSYSTSSLPAYYSSFSSSLRTNGKNSALRSAIETIRRTKNDSLYRETTSAFSNRFNSNNDQYEFSNYREHAPKYNNSIIPSEFESDNNSYYKYLQKFNKNIKRQNNYEKADINNYLINNWNKNNFELKSPTNKRKITPLYTKEQLMSKLSNTKDISERINILKSMIKSTKKESYYIDEFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVK7</accession>
    <name>Q5CVK7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627262.1">
        <property type="nucleotide sequence ID" value="XM_627262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVK7"/>
    <dbReference type="GeneID" id="3374311"/>
    <dbReference type="KEGG" id="cpv:cgd8_3700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3700"/>
    <dbReference type="InParanoid" id="Q5CVK7"/>
    <dbReference type="OrthoDB" id="338611at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="279" mass="31530" checksum="41D34F4A2BE70A4D" modified="2005-04-12" version="1">MDEEKSKTEEQNGSVSQNIKTISLNDKAILNNQSPIIVRRGDLSETALESSFSEPLSAIDDLKSGCNLFEKKSPRDEQLREKETKQALKSVMKLQNEIFHINNSIVSQENAYKSSLFSNKYMGNIFSSFSPFIKGINKFTLRPKEKSPEEVLKNIKKKSEEFQGRCNYIKYSTQWYLWAKRRNAETYSQNHLENTDQSSSNISNGVGNPPLGGTSSTNISNNANLSCQNNIGQVFQSNQLLLQKEIQNVEQSVKFRLAIQSDKPSFTFNSNICSSQLSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVN0</accession>
    <name>Q5CVN0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">methionine--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_3460</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.10" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627239.1">
        <property type="nucleotide sequence ID" value="XM_627239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVN0"/>
    <dbReference type="FunCoup" id="Q5CVN0">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVN0"/>
    <dbReference type="GeneID" id="3374619"/>
    <dbReference type="KEGG" id="cpv:cgd8_3460"/>
    <dbReference type="InParanoid" id="Q5CVN0"/>
    <dbReference type="OMA" id="VIWPCIL"/>
    <dbReference type="OrthoDB" id="5844513at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004825">
        <property type="term" value="F:methionine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006431">
        <property type="term" value="P:methionyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07957">
        <property type="entry name" value="Anticodon_Ia_Met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00814">
        <property type="entry name" value="MetRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.220.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041872">
        <property type="entry name" value="Anticodon_Met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014758">
        <property type="entry name" value="Met-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023457">
        <property type="entry name" value="Met-tRNA_synth_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015413">
        <property type="entry name" value="Methionyl/Leucyl_tRNA_Synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033911">
        <property type="entry name" value="MetRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00398">
        <property type="entry name" value="metG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326:SF2">
        <property type="entry name" value="METHIONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43326">
        <property type="entry name" value="METHIONYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19303">
        <property type="entry name" value="Anticodon_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09334">
        <property type="entry name" value="tRNA-synt_1g"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01041">
        <property type="entry name" value="TRNASYNTHMET"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7 11" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="9">
        <location>
            <begin position="36"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Leucyl tRNA synthetase" evidence="9">
        <location>
            <begin position="184"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl-tRNA synthetase anticodon-binding" evidence="10">
        <location>
            <begin position="458"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="556"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF19303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="581" mass="67224" checksum="538567AF21888FE8" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVN5</accession>
    <name>Q5CVN5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">S.cerevisiae Ssf2p/drosophila peter pan like protein that has an IMP4 domain at its N-terminus and is involved in rRNA processing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627234.1">
        <property type="nucleotide sequence ID" value="XM_627234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVN5"/>
    <dbReference type="STRING" id="353152.Q5CVN5"/>
    <dbReference type="GeneID" id="3374300"/>
    <dbReference type="KEGG" id="cpv:cgd8_3390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3390"/>
    <dbReference type="InParanoid" id="Q5CVN5"/>
    <dbReference type="OMA" id="KRTHAQI"/>
    <dbReference type="OrthoDB" id="10261452at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045112">
        <property type="entry name" value="PPAN-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661">
        <property type="entry name" value="PETER PAN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12661:SF5">
        <property type="entry name" value="SUPPRESSOR OF SWI4 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="27"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="346"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="363" mass="40985" checksum="E4D362330EFAA538" modified="2005-04-12" version="1">MPKLHGRRKKTKTHKKELVEEELKSIPKCFVLRKGKVVKQLKGLVMDLRYLMSPWSAIKLQENKHNKIKDFVSIAGPLGISHILAVSQTASGAYIRLIVLPSGPTATFKIEDFSLMHDIRSSQKRPRSCSSDYLTSPLLVLNGIKNLPSNDSTNPIPLNLLQTMINGMFPAIDLTKIRIRSCKRVVLIEYCKDSELFELRHYAIIRRPAGVSKPIKKLLLKTKDQKLYSIGRGDDMADYVLSSENGACASDSEVDDEVEVKMPTSSGSRDENQMGLSERSGSYTGKVSVSLKELGPRISMRLVKVVDEVCDGAVIYHRFVRKSKDELKELEKKEILLKERRKEENSLLNSYNEDNNSCKDTCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVR3</accession>
    <name>Q5CVR3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome activator p28/ Ki autoantigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_3090</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PA28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627206.1">
        <property type="nucleotide sequence ID" value="XM_627206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVR3"/>
    <dbReference type="FunCoup" id="Q5CVR3">
        <property type="interactions" value="249"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVR3"/>
    <dbReference type="GeneID" id="3374321"/>
    <dbReference type="KEGG" id="cpv:cgd8_3090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3090"/>
    <dbReference type="InParanoid" id="Q5CVR3"/>
    <dbReference type="OMA" id="KKPPKCG"/>
    <dbReference type="OrthoDB" id="6591885at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008537">
        <property type="term" value="C:proteasome activator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000045">
        <property type="term" value="P:regulation of G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.180:FF:000002">
        <property type="entry name" value="Proteasome activator complex subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.180">
        <property type="entry name" value="Proteasome activator pa28, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003186">
        <property type="entry name" value="PA28_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036997">
        <property type="entry name" value="PA28_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009077">
        <property type="entry name" value="Proteasome_activ_PA28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036252">
        <property type="entry name" value="Proteasome_activ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660:SF2">
        <property type="entry name" value="LD45860P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10660">
        <property type="entry name" value="PROTEASOME REGULATOR PA28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02252">
        <property type="entry name" value="PA28_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47216">
        <property type="entry name" value="Proteasome activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome activator PA28 C-terminal" evidence="3">
        <location>
            <begin position="88"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02252"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="234" mass="27110" checksum="450EEABF1F5932B7" modified="2005-04-12" version="1">MNKRPRESTLWSEYSSISLSSIEIIDSEVKKGCMEFRKDLSEQVTIHLRERIPSKIVQLNNRMKISDKPGSVLSSEELKPVNNGNGKVYSNLQIKELVAYVKQEVSELIEMVSSIKLWVQLNIPQIQDGNNFGVGIQEETIQELGRVEDATFSLYESVCKYYSERARLSSKIIKYPNVEDYVEAVRELDERYWVSLRCSIADMRNNYAWLHDLLTKNWEKLSKPRNSEGASMVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVV9</accession>
    <name>Q5CVV9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627160.1">
        <property type="nucleotide sequence ID" value="XM_627160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVV9"/>
    <dbReference type="GeneID" id="3374576"/>
    <dbReference type="KEGG" id="cpv:cgd8_2600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2600"/>
    <dbReference type="InParanoid" id="Q5CVV9"/>
    <dbReference type="OrthoDB" id="338695at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="139" mass="15985" checksum="97F1A801E9BE2932" modified="2005-04-12" version="1">METMQNWEIIDDYDIEKENEKVKNSDILSDLLSDYELDNSFMKKDINQQLEEINILIKEVNQEKVELLNSFPSCSLAIIKSLTRGDEIDEENMEIDQMSLSSSEINSSNDSPLFETRVNIDLHQSLTDSPGSMNISDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVX2</accession>
    <name>Q5CVX2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SAP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_2460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627147.1">
        <property type="nucleotide sequence ID" value="XM_627147.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVX2"/>
    <dbReference type="GeneID" id="3374272"/>
    <dbReference type="KEGG" id="cpv:cgd8_2460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2460"/>
    <dbReference type="InParanoid" id="Q5CVX2"/>
    <dbReference type="OMA" id="LYIFTID"/>
    <dbReference type="OrthoDB" id="343334at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.720.30">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003034">
        <property type="entry name" value="SAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036361">
        <property type="entry name" value="SAP_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02037">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00513">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF68906">
        <property type="entry name" value="SAP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50800">
        <property type="entry name" value="SAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAP" evidence="2">
        <location>
            <begin position="99"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="154"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="253"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="268"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="409" mass="46541" checksum="CFA98334D6B0D019" modified="2005-04-12" version="1">MNGNYHQERSRLIQQHKEEIKSIEKEIKSKRGTLKEQYQRQLEEAQKRHEDEMKEFESKYGNSEEKTKKGAKPASSSFSLGGEEKCNSEKTVLYEERQWNSLSKSELEAECKLRGLNSKGSKEDLVTRLFIFTADQKSKLSKISQNDQDSIKLVESRGKTSGQLESSSIKKFTMVSSTNKFTPPEINYSEAGGTGRRKGRSQNRKVDHRKNAKPGQNSWAAFCARNDIPRKKNADLNIHENSNSESSDDEENEKEKQSSSEGSHSEGESSVENSESGSSESDSDSEDIDEEELAKRNKRRAVMVKVLEKMFSSITINEKKNGLKLSEIQGQLTRLNVKNFKPELLGYKSVEDWVSSQPKTVLTYDEGNQLIFPPGYKIPASSKSKKEDPYYVDSLSEKEEEKSDDDFFM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVY4</accession>
    <name>Q5CVY4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_2320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627135.1">
        <property type="nucleotide sequence ID" value="XM_627135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVY4"/>
    <dbReference type="GeneID" id="3374459"/>
    <dbReference type="KEGG" id="cpv:cgd8_2320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2320"/>
    <dbReference type="InParanoid" id="Q5CVY4"/>
    <dbReference type="OrthoDB" id="341612at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="729" mass="84930" checksum="176107D47C3468DF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW11</accession>
    <name>Q5CW11_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">POZ domain protein, related to tetramerization domain of K channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627108.1">
        <property type="nucleotide sequence ID" value="XM_627108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW11"/>
    <dbReference type="STRING" id="353152.Q5CW11"/>
    <dbReference type="GeneID" id="3374413"/>
    <dbReference type="KEGG" id="cpv:cgd8_2040"/>
    <dbReference type="InParanoid" id="Q5CW11"/>
    <dbReference type="OMA" id="PMINDIV"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045068">
        <property type="entry name" value="BACURD1-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING ADAPTER FOR CUL3-MEDIATED RHOA DEGRADATION PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11145:SF8">
        <property type="entry name" value="RE57120P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="9"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="242" mass="28086" checksum="F85E3CDDD115C192" modified="2005-04-12" version="1" fragment="single">EIIIKMDEKRIKLNVGGIFYETTNTTLLSVNGDSNYFSAYLSRTENSYNTNLQSEEVIELFIDRNGFLFQYILDYLRTGTIVAIPNKDHIIRGLLIEADFYLLESLCSILSNKLLEQSMEKLNSNINLIASQSQSQSQSQSQSQNQSQCQIQSQFQSQCQSQLQSQSQSQIYNQSQTNMSDISEFNAPMINDIVKKEYLYNSHFINSIYSHYYDTENNSLKENENNTEKNYLKFEFSLDEDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW54</accession>
    <name>Q5CW54_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">18S rRNA aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="6">2.5.1.157</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd8_1580</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>an N(1)-methylpseudouridine in rRNA + S-adenosyl-L-methionine = N(1)-methyl-N(3)-[(3S)-3-amino-3-carboxypropyl]pseudouridine in rRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:63296"/>
            <dbReference type="Rhea" id="RHEA-COMP:11634"/>
            <dbReference type="Rhea" id="RHEA-COMP:16310"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74890"/>
            <dbReference type="ChEBI" id="CHEBI:146234"/>
            <dbReference type="EC" id="2.5.1.157"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the TDD superfamily. TSR3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.157" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627065.1">
        <property type="nucleotide sequence ID" value="XM_627065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW54"/>
    <dbReference type="FunCoup" id="Q5CW54">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW54"/>
    <dbReference type="GeneID" id="3374477"/>
    <dbReference type="KEGG" id="cpv:cgd8_1580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1580"/>
    <dbReference type="InParanoid" id="Q5CW54"/>
    <dbReference type="OMA" id="DCSWKSL"/>
    <dbReference type="OrthoDB" id="10262062at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106388">
        <property type="term" value="F:rRNA small subunit aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904047">
        <property type="term" value="F:S-adenosyl-L-methionine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01116">
        <property type="entry name" value="TSR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022968">
        <property type="entry name" value="Tsr3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007177">
        <property type="entry name" value="Tsr3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426:SF0">
        <property type="entry name" value="18S RRNA AMINOCARBOXYPROPYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20426">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN TSR3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04034">
        <property type="entry name" value="Ribo_biogen_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 6" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNase L inhibitor RLI-like possible metal-binding" evidence="9">
        <location>
            <begin position="131"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="16S/18S rRNA aminocarboxypropyltransferase Tsr3 C-terminal" evidence="8">
        <location>
            <begin position="169"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="32"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="302"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="32"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="66"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="319"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="195"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="233"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF04034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="330" mass="38370" checksum="55D0E8568FC8638D" modified="2005-04-12" version="1">MKSRNSTKTQIETDFVSEFISETDSSEIEYKFESGKNAELDKKDGEKVSKKADKDEAIEVNKEEKVEEEDDEEKGEEEEEEEEEEEEEEEEEEEEEEEEEEEEEDDDDDDDEEEEEDDEEEKEEPTIKIGLWDFCQCDVARCSGRKLLRFNYAKKLQFSSNYARKWPGIILSPRAKKKVSMEDLPLILKGGVGVIDCSWNKIDQVPFHKIHNGNERLLPFLVAANSTHYGRPYELSCAEAISACLFFFGFPKQAEKLLGIFKGGHHFLELNKEAFDLYKSKGINSQSIINAEQDFINKYMNKQKQRESRDYDSLFSSSYEDDDYDNDGKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW61</accession>
    <name>Q5CW61_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large protein with possibly 18 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_1510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627058.1">
        <property type="nucleotide sequence ID" value="XM_627058.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3374587"/>
    <dbReference type="KEGG" id="cpv:cgd8_1510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1510"/>
    <dbReference type="InParanoid" id="Q5CW61"/>
    <dbReference type="OMA" id="CTIMIVI"/>
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            <end position="286"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="293"/>
            <end position="313"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="551"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="581"/>
            <end position="600"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="625"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="826"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="969"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="981"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
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            <end position="1121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1142"/>
            <end position="1166"/>
        </location>
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        <location>
            <begin position="1232"/>
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        <location>
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        <location>
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        <location>
            <begin position="1425"/>
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        <location>
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        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
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        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1604" mass="185071" checksum="298C0E90C50B3011" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWB9</accession>
    <name>Q5CWB9_CRYPI</name>
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        <recommendedName>
            <fullName evidence="3">UDP-glucose 6-dehydrogenase</fullName>
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        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">cgd8_920</name>
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        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
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            <taxon>Eukaryota</taxon>
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            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
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                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>UDP-alpha-D-glucose + 2 NAD(+) + H2O = UDP-alpha-D-glucuronate + 2 NADH + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:23596"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="1.1.1.22"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-alpha-D-glucuronate biosynthesis; UDP-alpha-D-glucuronate from UDP-alpha-D-glucose: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.22" evidence="3"/>
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        <property type="nucleotide sequence ID" value="XM_627000.1"/>
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    <dbReference type="InParanoid" id="Q5CWB9"/>
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    <dbReference type="OrthoDB" id="5059218at2759"/>
    <dbReference type="UniPathway" id="UPA00038">
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    <dbReference type="GO" id="GO:0005634">
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        <property type="project" value="UniProtKB-EC"/>
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    </dbReference>
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    </dbReference>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR11374">
        <property type="entry name" value="UDP-GLUCOSE DEHYDROGENASE/UDP-MANNAC DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00984">
        <property type="entry name" value="UDPG_MGDP_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03721">
        <property type="entry name" value="UDPG_MGDP_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="UDPglc_DH_bac"/>
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    </dbReference>
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        <property type="entry name" value="UDPglc_GDPman_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00984">
        <property type="entry name" value="UDPG_MGDP_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52413">
        <property type="entry name" value="UDP-glucose/GDP-mannose dehydrogenase C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0520">NAD</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UDP-glucose/GDP-mannose dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="337"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="281"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="134"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="166"/>
            <end position="169"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="270"/>
            <end position="274"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="344"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="351"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR500134-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="544" mass="61168" checksum="8A76AB266E48CB35" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWE3</accession>
    <name>Q5CWE3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_5430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627861.1">
        <property type="nucleotide sequence ID" value="XM_627861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWE3"/>
    <dbReference type="GeneID" id="3375856"/>
    <dbReference type="KEGG" id="cpv:cgd6_5430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5430"/>
    <dbReference type="InParanoid" id="Q5CWE3"/>
    <dbReference type="OrthoDB" id="344227at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.970">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254488" evidence="3">
        <location>
            <begin position="23"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="428"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="448" mass="48226" checksum="E69182F09E7FF734" modified="2007-04-03" version="1">MKSLSLLSVFITYFLIIYTVSATELDSTENVVSTSLVGSADNSAEKFEEVASNKTSTIAPAEVSKLDEEAPTADQDSEHKSIDLSGESSVPILTKELDLESDPKSSIYTIEVHTKDEVEVPIVQSDEVMTLEVTSFTKEDETPASVEVTLDEVSTASELSGDEVQTAAELSGDEAPTVAELSGDEAPTVTELSGDEASATIELSSGVEQISDSAEKAGEKDQEETQESLVLHKYEVPLMFACETKKLICHNTSTSNAITIQGSRKGSALFASFDSSMIRSSGINSGDVVSATLILNKVGGTRTLPVRVDVLNLESKSSRISKSTVLATYRTVLPKTQNSPVSVDVTSAIRELLENAKDHEKFSILVSAYSNTRFGDILTFPTKDYPNGLTLELSLTKLPEKLSSSLDSTESVREVQSLRERIFSGQNLYIAMGILATVSIIVIVLMMM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWF3</accession>
    <name>Q5CWF3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_5320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627851.1">
        <property type="nucleotide sequence ID" value="XM_627851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWF3"/>
    <dbReference type="STRING" id="353152.Q5CWF3"/>
    <dbReference type="GeneID" id="3375846"/>
    <dbReference type="KEGG" id="cpv:cgd6_5320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5320"/>
    <dbReference type="InParanoid" id="Q5CWF3"/>
    <dbReference type="OMA" id="ERESWIC"/>
    <dbReference type="OrthoDB" id="372718at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="278"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="543"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="862"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="239"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
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            <begin position="334"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="432"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="706"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="252"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="334"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="434"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="732"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="770"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="936" mass="104864" checksum="7E674BAFFB95577E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWG0</accession>
    <name>Q5CWG0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription elongation factor, SPT6-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_5250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627844.1">
        <property type="nucleotide sequence ID" value="XM_627844.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWG0"/>
    <dbReference type="GeneID" id="3375839"/>
    <dbReference type="KEGG" id="cpv:cgd6_5250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5250"/>
    <dbReference type="InParanoid" id="Q5CWG0"/>
    <dbReference type="OMA" id="LDNEWIN"/>
    <dbReference type="OrthoDB" id="343921at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09918">
        <property type="entry name" value="SH2_Nterm_SPT6_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.650">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.505.10">
        <property type="entry name" value="SH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.850">
        <property type="entry name" value="Spt6, helix-hairpin-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3500.10">
        <property type="entry name" value="Tex N-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.140">
        <property type="entry name" value="YqgF/RNase H-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036860">
        <property type="entry name" value="SH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032706">
        <property type="entry name" value="Spt6_HHH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035420">
        <property type="entry name" value="Spt6_SH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035019">
        <property type="entry name" value="Spt6_SH2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023323">
        <property type="entry name" value="Tex-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023319">
        <property type="entry name" value="Tex-like_HTH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017072">
        <property type="entry name" value="TF_Spt6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037027">
        <property type="entry name" value="YqgF/RNaseH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10145:SF6">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14635">
        <property type="entry name" value="HHH_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14633">
        <property type="entry name" value="SH2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription elongation factor Spt6 helix-hairpin-helix motif" evidence="3">
        <location>
            <begin position="1388"/>
            <end position="1468"/>
        </location>
    </feature>
    <feature type="domain" description="Spt6 SH2" evidence="2">
        <location>
            <begin position="1879"/>
            <end position="2082"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="325"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1212"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1461"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1779"/>
            <end position="1799"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2104"/>
            <end position="2232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="115"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="194"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1114"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1215"/>
            <end position="1226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1468"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1780"/>
            <end position="1796"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="2133"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2145"/>
            <end position="2154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2166"/>
            <end position="2175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2221"/>
            <end position="2232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14633"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2232" mass="255491" checksum="D30BE532D4F36FE7" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWM0</accession>
    <name>Q5CWM0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_4530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627784.1">
        <property type="nucleotide sequence ID" value="XM_627784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWM0"/>
    <dbReference type="GeneID" id="3375790"/>
    <dbReference type="KEGG" id="cpv:cgd6_4530"/>
    <dbReference type="InParanoid" id="Q5CWM0"/>
    <dbReference type="OMA" id="IHQNANQ"/>
    <dbReference type="OrthoDB" id="343813at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="280"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="115"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="177"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="432"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="798" mass="88535" checksum="3D20A4388111E33A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWP0</accession>
    <name>Q5CWP0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">40S ribosomal protein S5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_4320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627764.1">
        <property type="nucleotide sequence ID" value="XM_627764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWP0"/>
    <dbReference type="FunCoup" id="Q5CWP0">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWP0"/>
    <dbReference type="GeneID" id="3375908"/>
    <dbReference type="KEGG" id="cpv:cgd6_4320"/>
    <dbReference type="InParanoid" id="Q5CWP0"/>
    <dbReference type="OMA" id="KMNIVER"/>
    <dbReference type="OrthoDB" id="10264639at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14867">
        <property type="entry name" value="uS7_Eukaryote"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.455.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.455.10">
        <property type="entry name" value="Ribosomal protein S7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000235">
        <property type="entry name" value="Ribosomal_uS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020606">
        <property type="entry name" value="Ribosomal_uS7_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023798">
        <property type="entry name" value="Ribosomal_uS7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036823">
        <property type="entry name" value="Ribosomal_uS7_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005716">
        <property type="entry name" value="Ribosomal_uS7_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003106">
        <property type="entry name" value="PRK04027.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01028">
        <property type="entry name" value="uS7_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11205">
        <property type="entry name" value="RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00177">
        <property type="entry name" value="Ribosomal_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002122">
        <property type="entry name" value="RPS7p_RPS7a_RPS5e_RPS7o"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47973">
        <property type="entry name" value="Ribosomal protein S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00052">
        <property type="entry name" value="RIBOSOMAL_S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS7" evidence="5">
        <location>
            <begin position="58"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="207" mass="23138" checksum="16E6E03ECA7B87EE" modified="2005-04-12" version="1" fragment="single">FKKIGLRNEVKMATFSTSDVKLFGKWSYDDVNVSDLSLVDYIAVKDKACVYAPVTAGRYQVKRFRKALCPIVERLVCSLMMHGRNNGKKNQAIRIVRAAFDIIHLVTDQNPIQVFVDAVKNGGPREDSTSIGSAGAVRRQAVDVSPLRRVNQAIYLICTGARTQAFRNIKTIAECLADEIMNCAKENPNSYAIKRKDEVERVAKANR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWP8</accession>
    <name>Q5CWP8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MO25 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_4240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mo25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627756.1">
        <property type="nucleotide sequence ID" value="XM_627756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWP8"/>
    <dbReference type="STRING" id="353152.Q5CWP8"/>
    <dbReference type="GeneID" id="3375768"/>
    <dbReference type="KEGG" id="cpv:cgd6_4240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4240"/>
    <dbReference type="InParanoid" id="Q5CWP8"/>
    <dbReference type="OrthoDB" id="609103at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043539">
        <property type="term" value="F:protein serine/threonine kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013878">
        <property type="entry name" value="Mo25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10182:SF3">
        <property type="entry name" value="PROTEIN MO25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08569">
        <property type="entry name" value="Mo25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="53"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="509" mass="59610" checksum="406890AB64E85971" modified="2005-04-12" version="1">MLNWIHLQKNSSTNLGADYDDDGNYCINNDNKSNNISDSNGIISKIGKSIIGNNVEKEKNNLENEEYEKVKRKFLQVCNEINVNIIKLINSVLVKDEDNIEKLEKRDEREKIFEKVISYRKDFNNIFSTEKKELSLRGPLDEIKFIFLDLVDKQEKELNLWLNDRNQQKMEWNERVERIYKQIFTLSEIFCDSLLLNITCVLGYVSMEEHSLWVSIISLLIVFEIRSCQHTVLLKENELINEIDQENFVILEWLNKNCDEFFSLLLKQYSIIPITYKIGEVLRDISTILNLAQGPGIVDKQNNKTFPISESFKNKSNEIAEHLIYKQEIFTNLIKLSGNQCFDISSDSISTLRCYLFVSPKITNEYILKNQQDFFSNIFKILIQSTEYVPQRHGLRLLNQLLSLKELSKVMTAFSSNCEYLKIFMNLITSHLNTTSFEAFHIFKLFVANPNKSPGIQKILFKNKDKIVEFLIHFQTSRTDPQFISDKQVSHLLHTSIILLIITFYYFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWT4</accession>
    <name>Q5CWT4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Cleavage and polyadenylation specificity factor subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Iowa type II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family. CPSF5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627720.1">
        <property type="nucleotide sequence ID" value="XM_627720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWT4"/>
    <dbReference type="FunCoup" id="Q5CWT4">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWT4"/>
    <dbReference type="GeneID" id="3375736"/>
    <dbReference type="KEGG" id="cpv:cgd6_3810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3810"/>
    <dbReference type="InParanoid" id="Q5CWT4"/>
    <dbReference type="OMA" id="NDEWEIG"/>
    <dbReference type="OrthoDB" id="277288at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005849">
        <property type="term" value="C:mRNA cleavage factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016706">
        <property type="entry name" value="Cleav_polyA_spec_factor_su5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13047">
        <property type="entry name" value="PRE-MRNA CLEAVAGE FACTOR IM, 25KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13869">
        <property type="entry name" value="NUDIX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017888">
        <property type="entry name" value="CPSF-25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR017888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="277" mass="31390" checksum="2CE5E1DC89F3CE43" modified="2007-04-03" version="1">MQEGSNNVSNNLMNDNKIEEDVLEQPTFLTNQSLLNEEQSMATNVDHEPSWLIYPLKNYGIRVQDNSDEIQSSIPINEMNGFNVKVDNFLKDGIGRSVAALMLTHRYLCPHVVLLQNDLTSEWMLPNCTYKAWENPRIVLANFLKSMFLTSSSINSNTNNSGSNNGNNNSSTNNNNINNACSDNAVEVGEYLGTWWRTEFNYSPLPYLPPHSTRPKETIRIYQVILPPKLLFKLPKHHVLKSLPLFDLDPNIFGIACGSIPQLISRFQIQSMVQSDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXD2</accession>
    <name>Q5CXD2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_1550</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EAF6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627522.1">
        <property type="nucleotide sequence ID" value="XM_627522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXD2"/>
    <dbReference type="STRING" id="353152.Q5CXD2"/>
    <dbReference type="GeneID" id="3376019"/>
    <dbReference type="KEGG" id="cpv:cgd6_1550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1550"/>
    <dbReference type="InParanoid" id="Q5CXD2"/>
    <dbReference type="OMA" id="GWDGYIN"/>
    <dbReference type="OrthoDB" id="440324at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015418">
        <property type="entry name" value="Eaf6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13476">
        <property type="entry name" value="CHROMATIN MODIFICATION-RELATED PROTEIN MEAF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09340">
        <property type="entry name" value="NuA4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="10"/>
            <end position="38"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="193" mass="21283" checksum="6091583AEBDED40D" modified="2007-04-03" version="1">MKQKSENKGKGSSNESQGTHQSSNYLNKDSSIPTNFCQESPHKKLSNEMVSLREKVQEELVDIERKIYELETFYWNQTTDIGNMLRGWDGYATYNSNTGSIGGRKSSIGGNRGSCRSNPNVFSEKDRWFSLSSVTSPVDIEALGTTPNTGAHSGEMFSAAGSNVGSSISYHSESQCQGSELDNSVNCSRKQRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXE3</accession>
    <name>Q5CXE3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transcription factor E2F wHTH only</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_1430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627511.1">
        <property type="nucleotide sequence ID" value="XM_627511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXE3"/>
    <dbReference type="STRING" id="353152.Q5CXE3"/>
    <dbReference type="GeneID" id="3376012"/>
    <dbReference type="KEGG" id="cpv:cgd6_1430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1430"/>
    <dbReference type="InParanoid" id="Q5CXE3"/>
    <dbReference type="OMA" id="HGHLRED"/>
    <dbReference type="OrthoDB" id="1743261at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090575">
        <property type="term" value="C:RNA polymerase II transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015633">
        <property type="entry name" value="E2F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12081:SF18">
        <property type="entry name" value="TRANSCRIPTION FACTOR E2F2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0804">Transcription</keyword>
    <keyword evidence="2 5" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="7">
        <location>
            <begin position="368"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="104"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="263"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="545"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="588"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="636"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="104"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="125"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="208"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="287"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="594"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="647"/>
            <end position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="666" mass="70297" checksum="5F7913EACBF35707" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXE5</accession>
    <name>Q5CXE5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_1380</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family. HD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627509.1">
        <property type="nucleotide sequence ID" value="XM_627509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXE5"/>
    <dbReference type="STRING" id="353152.Q5CXE5"/>
    <dbReference type="GeneID" id="3375869"/>
    <dbReference type="KEGG" id="cpv:cgd6_1380"/>
    <dbReference type="InParanoid" id="Q5CXE5"/>
    <dbReference type="OMA" id="ITDFYYL"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031507">
        <property type="term" value="P:heterochromatin formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09991">
        <property type="entry name" value="HDAC_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF10">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="8">
        <location>
            <begin position="32"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="145"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="268"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="440" mass="49745" checksum="DB505FD3202D3F9F" modified="2005-04-12" version="1" fragment="single">RYLLYKLSMGAKKKIAYFYDEEVGNFHYGLGHPMKPHRVRMTHDLVSQYGLLEKVDVMVPTPGTVESLTRFHSNDYVDFLRSVNTDNMHDYSDHLARFNVGEDCPVFDGLWEFCQLSAGGSLGGAQSVNELGYQYAINWAGGLHHGKKHEASGFCYVNDCVLGALEFLKYQHRVCYVDIDIHHGDGVEEAFYTSPRCMCVSFHKYGDYFPGTGALNDVGVEEGLGYSVNVPLKDGVDDATFIDLFTKVMTLVMENYRPGAIVLQCGADSLSGDRLGCFNLSLKGHGHAVSFLKKFNVPLLILGGGGYTLRNVPKCWTYETSLIVDTYIDEQLPNSSNFYGYYGPDFSLAVRTSNMENLNSRQDCEEIYRKISENFRDYVFPIGSQISAYDIPEKLPLLYNPNKTPDDYKDGNNIKHEQHQDFDDEMKEWPTVDYNNRAIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXM7</accession>
    <name>Q5CXM7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627427.1">
        <property type="nucleotide sequence ID" value="XM_627427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXM7"/>
    <dbReference type="STRING" id="353152.Q5CXM7"/>
    <dbReference type="GeneID" id="3376106"/>
    <dbReference type="KEGG" id="cpv:cgd6_440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_440"/>
    <dbReference type="InParanoid" id="Q5CXM7"/>
    <dbReference type="OrthoDB" id="343114at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF803">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="11">
        <location>
            <begin position="279"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="533" mass="61955" checksum="B9595B308688EC0D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXR3</accession>
    <name>Q5CXR3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_5240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628667.1">
        <property type="nucleotide sequence ID" value="XM_628665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXR3"/>
    <dbReference type="GeneID" id="3372097"/>
    <dbReference type="KEGG" id="cpv:cgd7_5240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5240"/>
    <dbReference type="InParanoid" id="Q5CXR3"/>
    <dbReference type="OMA" id="IRICKLF"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="407" mass="47050" checksum="46D8D09316D1676A" modified="2005-04-12" version="1">MFKKNRKNKKLLIGTVGANYDGTITKYNTFETVILQACKKYYSNKPQACDMLLLEQEAEKILNTHINDRLLWCNEWLPETPLEKFDGNAIAKIFLAISEFEYIYNFKIEKEMKILQFLNSDIVDGSSVEFKEGWEFREGAFETLKSLCEFTNRFIIVSTSKGSKRIKDTVEGILSDNEGKCELEISASEFEYKSESCDTVETAPNSLYGPSCKYRAFRQSVKEINKQYNKRMRDKIHYVIASISMNAISKYDIYIKSIFFGNKVNDLECILYSEIGVIIADSPALDNICDAKTSEHSSIVELSQHSSLSATENTLNIDHFMFKICLLFSIQIVPISNDHTERIQNSGLKVYKDILRDEEGIADIRDFLRVSRMMRHHNSKTSQFRFNGILLLAFSWDEVSRFFFPKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXW2</accession>
    <name>Q5CXW2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ring finger domain protein and 2 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628618.1">
        <property type="nucleotide sequence ID" value="XM_628616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXW2"/>
    <dbReference type="GeneID" id="3372194"/>
    <dbReference type="KEGG" id="cpv:cgd7_4700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4700"/>
    <dbReference type="InParanoid" id="Q5CXW2"/>
    <dbReference type="OMA" id="NELERCC"/>
    <dbReference type="OrthoDB" id="429628at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="168"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="215" mass="24618" checksum="523063664FA0F305" modified="2005-04-12" version="1">MPEYIQIVGDEDSRSNTNDTCFICLEDSSQGKLKRCCSQCYAVVHGKCWSKWSSSQQIAILRSILLGEERRELKLCSICRSGSIKIEHSEDDSEDFSKALNGGLIYRFFRIIANRVYGNQYGSFMVSSVDNPFSNLRTLLINGVFLSLFFIYILYQEEHSDAKSLITISLWAYITLVLQFLTITGVYRRQVLDELAIDEPSLTDTYESVRPNEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXX5</accession>
    <name>Q5CXX5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Gigantic extracellular protein with interesting sushi (9x) and archaeal protease type repeats having the domain architecture: signal peptide-CRYPB(3x)-sushi (9x)-archaeoglobus type repeats (2x)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_4560</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628605.1">
        <property type="nucleotide sequence ID" value="XM_628603.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372183"/>
    <dbReference type="KEGG" id="cpv:cgd7_4560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4560"/>
    <dbReference type="InParanoid" id="Q5CXX5"/>
    <dbReference type="OMA" id="MCKPACK"/>
    <dbReference type="OrthoDB" id="331862at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032812">
        <property type="entry name" value="SbsA_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13205">
        <property type="entry name" value="Big_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2941"/>
            <end position="2963"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1201"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1436"/>
            <end position="1498"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1502"/>
            <end position="1569"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1573"/>
            <end position="1632"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="6">
        <location>
            <begin position="1636"/>
            <end position="1699"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="736"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1158"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="3057"/>
            <end position="3082"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="2057"/>
            <end position="2084"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="3063"/>
            <end position="3074"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="3082" mass="343796" checksum="C4634B5F76D63B9A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY24</accession>
    <name>Q5CY24_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2*FF domain protein (Phosphopeptide binding)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628556.1">
        <property type="nucleotide sequence ID" value="XM_628554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY24"/>
    <dbReference type="STRING" id="353152.Q5CY24"/>
    <dbReference type="GeneID" id="3372062"/>
    <dbReference type="KEGG" id="cpv:cgd7_3950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3950"/>
    <dbReference type="InParanoid" id="Q5CY24"/>
    <dbReference type="OMA" id="WHISIPT"/>
    <dbReference type="OrthoDB" id="187617at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.440">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036517">
        <property type="entry name" value="FF_domain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81698">
        <property type="entry name" value="FF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="431" mass="51981" checksum="A96209D851EAE8FE" modified="2005-04-12" version="1">MVLNKNDAIQIIKKYLEGAELNSKVRWDEAAKLLGPDAPHEALKLLSTGEKRQIWSEYQSQSKRRKRERERQTKSESINTYRGLLNDWVLKNQGCNRILLFRNFAEEHYKSVWWNNIEDKEKDEIFQELVEEHEKNFIRTLEPNYEENVNDFFELLRLETTIFPFLESNKAESSIIRNGESIEKKNFTGFGIWEDLQKKYGKEQLFKKVYKDDILDIYIRLLKGKINIYKQEHLKTETEFCKYRKMFWDIIWSDILSGKISPITKNRKSYFFTNSKINDEKIEALHRLISKRIRYQKSESYFEYFEDFLKFIGFHLSIRKDQKVILALLKQPINNGMNLYCIDMFEYIAYLLQKLYDIILSESYTYFKSSEKFQISFQQFKEITYNNKNIMDFKTKYIFPFSFESVLDAILYKAYCDEFKHYSLTSSLKKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYB7</accession>
    <name>Q5CYB7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628463.1">
        <property type="nucleotide sequence ID" value="XM_628461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYB7"/>
    <dbReference type="GeneID" id="3372279"/>
    <dbReference type="KEGG" id="cpv:cgd7_2960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2960"/>
    <dbReference type="InParanoid" id="Q5CYB7"/>
    <dbReference type="OrthoDB" id="343422at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="147"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="346" mass="39654" checksum="27E42B65BFEDA11E" modified="2005-04-12" version="1">MMNMDKKHNSFFSNLKGKYKVFSMNNAKHRIFSRKKAGSKKCENEKIKGINVSFENTYLDSIVNSSNEHISSNCMSSSPDNMSHDSNNCNSQERQGSKFEYKLSKSTTKIENKTAINSNSSPSLNETFSDNSSTSLFSDSSTILSSKYKSNHSSDTQSSTYNRSNIQDYNQNTDYNCSDTSRKENISQEQGIPIKKRIENAVEGKKKTKLQPYKRNNSGENNNCRESKPYLNKEILDILNSKYHNREEKRTTQQVVAIEDLGVDDKNTEINAISRSENNSYRQEVERYLFKDLNVYFGWETPLVIPIITEPDCCYQSSYSNYDILIDYACIDGDKCHLCSFIEGIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYD4</accession>
    <name>Q5CYD4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628446.1">
        <property type="nucleotide sequence ID" value="XM_628444.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372263"/>
    <dbReference type="KEGG" id="cpv:cgd7_2770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2770"/>
    <dbReference type="InParanoid" id="Q5CYD4"/>
    <dbReference type="OMA" id="WFTEDIN"/>
    <dbReference type="OrthoDB" id="340317at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1326"/>
            <end position="1354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1517" mass="173891" checksum="01F7FC77E4EF4435" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYF7</accession>
    <name>Q5CYF7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_2510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628423.1">
        <property type="nucleotide sequence ID" value="XM_628421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYF7"/>
    <dbReference type="GeneID" id="3371919"/>
    <dbReference type="KEGG" id="cpv:cgd7_2510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2510"/>
    <dbReference type="InParanoid" id="Q5CYF7"/>
    <dbReference type="OMA" id="LFFDRSW"/>
    <dbReference type="OrthoDB" id="443651at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015293">
        <property type="term" value="F:symporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036458">
        <property type="entry name" value="Na:dicarbo_symporter_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118215">
        <property type="entry name" value="Proton glutamate symport protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="121"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="163"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="244" mass="26937" checksum="05F3D2160DCCECCD" modified="2005-04-12" version="1">MASSIMETFGSLNYEEAFSKRGIISTIVGILLGLVVSTTVNATLVEISLSPFFSTYFGLLFVIIGGLIFWKVYVTIIPDEENALNKRTSLLTFAALIIFSGFICFILENDWFLGMTPIIRVPIYTILGLSISFAIAFSLVDAVNYISGFISSNDSPLLVNSKAQIIFVICSSLFIGIIFGFLFGLVEDTHEQIHYVNISLMKQKHYCYTIGVIVGALCGFGNEVIRLSDRSYMIVGKTVYDSDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYL5</accession>
    <name>Q5CYL5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_1880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL42 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628365.1">
        <property type="nucleotide sequence ID" value="XM_628363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYL5"/>
    <dbReference type="FunCoup" id="Q5CYL5">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYL5"/>
    <dbReference type="GeneID" id="3371793"/>
    <dbReference type="KEGG" id="cpv:cgd7_1880"/>
    <dbReference type="InParanoid" id="Q5CYL5"/>
    <dbReference type="OMA" id="CKKHTIH"/>
    <dbReference type="OrthoDB" id="2967263at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.80:FF:000001">
        <property type="entry name" value="60S ribosomal protein L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000552">
        <property type="entry name" value="Ribosomal_eL44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053708">
        <property type="entry name" value="Ribosomal_LSU_eL42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10369">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36A/L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00935">
        <property type="entry name" value="Ribosomal_L44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01172">
        <property type="entry name" value="RIBOSOMAL_L44E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="104" mass="12143" checksum="A223FF93C95B0A2E" modified="2005-04-12" version="1" fragment="single">VNIPKLRNTFCKGSDCRKHTPHKVSQYKRGKESPRAQGRRRYDQKQKGYGGQTKPKLRKTAKTTKKIVLRLECTKCKQRRFLAIKRCKHFQLGGDKKRKGGPVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYV6</accession>
    <name>Q5CYV6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HEAT repeat-containing protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Involved in nucleolar processing of pre-18S ribosomal RNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the HEATR1/UTP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628274.1">
        <property type="nucleotide sequence ID" value="XM_628272.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYV6"/>
    <dbReference type="GeneID" id="3371985"/>
    <dbReference type="KEGG" id="cpv:cgd7_860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_860"/>
    <dbReference type="InParanoid" id="Q5CYV6"/>
    <dbReference type="OMA" id="YLLLMQS"/>
    <dbReference type="OrthoDB" id="31183at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034455">
        <property type="term" value="C:t-UTP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040191">
        <property type="entry name" value="UTP10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457">
        <property type="entry name" value="BAP28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13457:SF1">
        <property type="entry name" value="HEAT REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="1" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2346"/>
            <end position="2380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2352"/>
            <end position="2367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2368"/>
            <end position="2378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2776" mass="323583" checksum="6CE43FAD0D280A28" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYX8</accession>
    <name>Q5CYX8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec14d domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628252.1">
        <property type="nucleotide sequence ID" value="XM_628250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYX8"/>
    <dbReference type="GeneID" id="3372006"/>
    <dbReference type="KEGG" id="cpv:cgd7_620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_620"/>
    <dbReference type="InParanoid" id="Q5CYX8"/>
    <dbReference type="OMA" id="IMINLHY"/>
    <dbReference type="OrthoDB" id="342170at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902936">
        <property type="term" value="F:phosphatidylinositol bisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174">
        <property type="entry name" value="ALPHA-TOCOPHEROL TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10174:SF208">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN DDB_G0278031"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="150"/>
            <end position="323"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="403" mass="47276" checksum="B760A47AC8C0975A" modified="2005-04-12" version="1">MSGIKKSMIDEFEFNSSPLYGEDLSDQIYNYSYEEERDKHSNNTTSTREKNENVNLHIQKGGIRTKTVKEVKQLRNMSEKLQRYSYKFSPIDNTVDRELTRSSWTREEIALFCLRSMNNNVKKAIKSYKCFTTMMCKFNSKNGNEIDIYNPTILSQLRSGKVVIFDKLDLHGRILVIVNLHHHDPRLQTVDDLILLFVFVLELIMIENPHDYAAERNGISVLINASKIGFGDFRIEYCTRIIQLLKKNFPIKMGQVLIFKPNRLIKLSIKLALLTKKKIKRKIQIINKVFEPLDSITDFDALSHFIDRKYIPEEFGGNHYFDFNNFWELKYQGHMLAELFQKRGASIKIQEPTKMLTNEKIKNDSKDKGKKKKKKDCKVSSINEKDRLILSNFYYSKTSFDIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ21</accession>
    <name>Q5CZ21_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SprT family metallopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628209.1">
        <property type="nucleotide sequence ID" value="XM_628207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ21"/>
    <dbReference type="STRING" id="353152.Q5CZ21"/>
    <dbReference type="GeneID" id="3372033"/>
    <dbReference type="KEGG" id="cpv:cgd7_140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_140"/>
    <dbReference type="InParanoid" id="Q5CZ21"/>
    <dbReference type="OMA" id="LANTQPC"/>
    <dbReference type="OrthoDB" id="20772at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099:SF0">
        <property type="entry name" value="GERM CELL NUCLEAR ACIDIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23099">
        <property type="entry name" value="TRANSCRIPTIONAL REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="2">
        <location>
            <begin position="357"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="598" mass="69525" checksum="50475F278ECD4045" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPP0</accession>
    <name>A3FPP0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Skp1 family protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_2500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the SKP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388386.1">
        <property type="nucleotide sequence ID" value="XM_001388349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPP0"/>
    <dbReference type="FunCoup" id="A3FPP0">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPP0"/>
    <dbReference type="GeneID" id="3371828"/>
    <dbReference type="KEGG" id="cpv:cgd7_2500"/>
    <dbReference type="InParanoid" id="A3FPP0"/>
    <dbReference type="OMA" id="DKYTASM"/>
    <dbReference type="OrthoDB" id="2342932at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18322">
        <property type="entry name" value="BTB_POZ_SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.710.10:FF:000026">
        <property type="entry name" value="E3 ubiquitin ligase complex SCF subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016897">
        <property type="entry name" value="SKP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001232">
        <property type="entry name" value="SKP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036296">
        <property type="entry name" value="SKP1-like_dim_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016072">
        <property type="entry name" value="Skp1_comp_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016073">
        <property type="entry name" value="Skp1_comp_POZ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11165">
        <property type="entry name" value="SKP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01466">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03931">
        <property type="entry name" value="Skp1_POZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028729">
        <property type="entry name" value="E3_ubiquit_lig_SCF_Skp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00512">
        <property type="entry name" value="Skp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81382">
        <property type="entry name" value="Skp1 dimerisation domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="SKP1 component POZ" evidence="5">
        <location>
            <begin position="4"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="SKP1 component dimerisation" evidence="4">
        <location>
            <begin position="112"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR028729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="162" mass="18528" checksum="BD99F7870EE678E3" modified="2007-04-03" version="1">MIFPKVRLLSSEGEEFAVDVRVATASTLVRNIIEADVGIDDPVPLPNVRGDVLRKVLDYCEYHVDNPSKEIPKPLRSNSLSNIVCEWDEEFVNIQQEFLFELMLAANYLDIKPLLDLSCAKVATMIKGKKAEEIRQIFNIENDFTPEEESAIREENKWCDEP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPW8</accession>
    <name>A3FPW8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Kinesin-like boursin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd6_4210</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-5/BimC subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388347.1">
        <property type="nucleotide sequence ID" value="XM_001388310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPW8"/>
    <dbReference type="SMR" id="A3FPW8"/>
    <dbReference type="STRING" id="353152.A3FPW8"/>
    <dbReference type="GeneID" id="3375972"/>
    <dbReference type="KEGG" id="cpv:cgd6_4210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4210"/>
    <dbReference type="InParanoid" id="A3FPW8"/>
    <dbReference type="OMA" id="DCEANVQ"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005876">
        <property type="term" value="C:spindle microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008574">
        <property type="term" value="F:plus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090307">
        <property type="term" value="P:mitotic spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01364">
        <property type="entry name" value="KISc_BimC_Eg5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000019">
        <property type="entry name" value="Kinesin-like protein KIN-5D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047149">
        <property type="entry name" value="KIF11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047241">
        <property type="entry name" value="KIF11-like_kin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970:SF12">
        <property type="entry name" value="KINESIN FAMILY MEMBER 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47970">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="12">
        <location>
            <begin position="17"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1103"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1153"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="371"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="727"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1153"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="11">
        <location>
            <begin position="1173"/>
            <end position="1184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="108"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAZ51541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1184" mass="134672" checksum="5C642D373D17AF63" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ83</accession>
    <name>A3FQ83_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_2250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RER1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388219.1">
        <property type="nucleotide sequence ID" value="XM_001388182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ83"/>
    <dbReference type="FunCoup" id="A3FQ83">
        <property type="interactions" value="415"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ83"/>
    <dbReference type="GeneID" id="3373436"/>
    <dbReference type="KEGG" id="cpv:cgd2_2250"/>
    <dbReference type="InParanoid" id="A3FQ83"/>
    <dbReference type="OMA" id="IDKWIMH"/>
    <dbReference type="OrthoDB" id="448250at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004932">
        <property type="entry name" value="Rer1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10743:SF0">
        <property type="entry name" value="PROTEIN RER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03248">
        <property type="entry name" value="Rer1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016013">
        <property type="entry name" value="AtER_Rer1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="17"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="165" mass="19564" checksum="27DBE0C43AD21133" modified="2007-04-03" version="1" fragment="single">NNNVSIYYKIYLTYSIFIWYIFLNALIIGFFIVTYGLSIYLLNLFIGFLSPQIDPEEEGMVLPMHDTQEFRPFERRLPEFKFWISATKATIASIFLTFFEVFDLPVFWPILLIYFIFLFILTMRQQIQHMIKYRYVPFSWGKQTYGDITKGKPTINKKTSLGGIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQB8</accession>
    <name>A3FQB8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388140.1">
        <property type="nucleotide sequence ID" value="XM_001388103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQB8"/>
    <dbReference type="STRING" id="353152.A3FQB8"/>
    <dbReference type="GeneID" id="3371501"/>
    <dbReference type="KEGG" id="cpv:cgd1_560"/>
    <dbReference type="InParanoid" id="A3FQB8"/>
    <dbReference type="OMA" id="CIDWITS"/>
    <dbReference type="OrthoDB" id="239865at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051150">
        <property type="entry name" value="SWT21/TCAB1_mRNA_Telomere"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13211:SF0">
        <property type="entry name" value="TELOMERASE CAJAL BODY PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAZ51317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="312" mass="36471" checksum="440CF71CE391FAFE" modified="2007-04-03" version="1">MIFRGNIRSISRNKQIRDHLRTNNMALFALNCRNYPVKVYNFDGELITSVYMRNQFEEIDEIYSLEFIYSEESSIILGGGKNCIHVYDYNSDSENFNSKECKIENSKCQKGIISCLSLKTSGIGSFSVFASGSFSKTIFLHDLSDLHSQIQLSDNNLNLNSVTELYWLDGSYDSKFMDYHLISGHRNSDYLYIWDVRKPNNILFKLDRENFGSNQRYNINLKYFEDELILTYGDSRGNLNIQKLKFNYDYNKFLQNVKQRQKIKLKSQSIPCVERFFDQKLLVTLSGERFTSCEKDQGCTFNVWKINTNTPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQE0</accession>
    <name>A3FQE0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Probable cytosolic iron-sulfur protein assembly protein CIAO1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_2230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat CIA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388162.1">
        <property type="nucleotide sequence ID" value="XM_001388125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQE0"/>
    <dbReference type="STRING" id="353152.A3FQE0"/>
    <dbReference type="GeneID" id="3371407"/>
    <dbReference type="KEGG" id="cpv:cgd1_2230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2230"/>
    <dbReference type="InParanoid" id="A3FQE0"/>
    <dbReference type="OMA" id="IREIRWS"/>
    <dbReference type="OrthoDB" id="284782at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097361">
        <property type="term" value="C:cytosolic [4Fe-4S] assembly targeting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03037">
        <property type="entry name" value="ciao1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028608">
        <property type="entry name" value="CIAO1/Cia1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR PROTEIN ASSEMBLY PROTEIN CIAO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19920">
        <property type="entry name" value="WD40 PROTEIN CIAO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="74"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="228"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="360"/>
            <end position="398"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="398" mass="45300" checksum="622E26BD29A40319" modified="2007-04-03" version="1">MGSLEKLGIIGVLDSAIWSVASHPKDRIIASCGSSIVVWMDTKLKNHKWYQEIEIVNKCSMAGNSWVKAYEFGSLEHKRLIRKIAWSPCGGMIISASFDSSISVWEFVSRDIGWACICKILGPESEVKCVDWSPFNNFVAACCRDRAIWFFSLDIGENRKLGTLIEYDCIGVVTAHTNDIKKIKWHPTIPMVLLSCSYDNTIIAWAPSSQLLGHDEVKGLEWVKLYTLNGHSSTVWDFTYSPNGEFLLSCSDDSSIVLWNSNQGNENKFKNLNSVNFALTDTFKMIFYNTPNTKRLSKYIQIDQANSFINNYDKELYSYPIYSIEWCNYINCIIVSSADKSLHLFSVTDSKRLKHICERPNAHNSEINSVSWLNDNKRGEFISAGDDGEIALWRFDFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQM0</accession>
    <name>A3FQM0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Heat shock 105kD heat shock 105kD alpha heat shock 105kD beta heat shock 105kDa protein 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_3270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388075.1">
        <property type="nucleotide sequence ID" value="XM_001388038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQM0"/>
    <dbReference type="SMR" id="A3FQM0"/>
    <dbReference type="FunCoup" id="A3FQM0">
        <property type="interactions" value="102"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQM0"/>
    <dbReference type="GeneID" id="3372773"/>
    <dbReference type="KEGG" id="cpv:cgd4_3270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3270"/>
    <dbReference type="InParanoid" id="A3FQM0"/>
    <dbReference type="OMA" id="WEQSPEI"/>
    <dbReference type="OrthoDB" id="434160at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000029">
        <property type="entry name" value="Heat shock protein 110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF4">
        <property type="entry name" value="HSC70CB, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="497"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="751"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="806" mass="90710" checksum="9DCC83B066C06926" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQP2</accession>
    <name>A3FQP2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec1 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAZ51227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388289.1">
        <property type="nucleotide sequence ID" value="XM_001388252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQP2"/>
    <dbReference type="FunCoup" id="A3FQP2">
        <property type="interactions" value="523"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQP2"/>
    <dbReference type="GeneID" id="3372561"/>
    <dbReference type="KEGG" id="cpv:cgd5_3700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3700"/>
    <dbReference type="InParanoid" id="A3FQP2"/>
    <dbReference type="OMA" id="TMNIHIH"/>
    <dbReference type="OrthoDB" id="10251230at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="666" mass="75059" checksum="66C1C7DA964DC394" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPE1</accession>
    <name>Q5CPE1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">GMP synthase (glutamine-hydrolyzing)</fullName>
            <ecNumber evidence="2">6.3.5.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Glutamine amidotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd5_4520</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Purine metabolism; GMP biosynthesis; GMP from XMP (L-Gln route): step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.5.2" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000018">
        <property type="protein sequence ID" value="EAK87292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625300.1">
        <property type="nucleotide sequence ID" value="XM_625300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPE1"/>
    <dbReference type="FunCoup" id="Q5CPE1">
        <property type="interactions" value="492"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPE1"/>
    <dbReference type="GeneID" id="3372305"/>
    <dbReference type="KEGG" id="cpv:cgd5_4520"/>
    <dbReference type="InParanoid" id="Q5CPE1"/>
    <dbReference type="OMA" id="IWQSFAV"/>
    <dbReference type="OrthoDB" id="1724632at2759"/>
    <dbReference type="UniPathway" id="UPA00189">
        <property type="reaction ID" value="UER00296"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003921">
        <property type="term" value="F:GMP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01742">
        <property type="entry name" value="GATase1_GMP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01997">
        <property type="entry name" value="GMP_synthase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001674">
        <property type="entry name" value="GMP_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004739">
        <property type="entry name" value="GMP_synth_GATase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025777">
        <property type="entry name" value="GMPS_ATP_PPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022310">
        <property type="entry name" value="NAD/GMP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00888">
        <property type="entry name" value="guaA_Nterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922:SF2">
        <property type="entry name" value="GMP SYNTHASE [GLUTAMINE-HYDROLYZING]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11922">
        <property type="entry name" value="GMP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00958">
        <property type="entry name" value="GMP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02540">
        <property type="entry name" value="NAD_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54810">
        <property type="entry name" value="GMP synthetase C-terminal dimerisation domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51553">
        <property type="entry name" value="GMPS_ATP_PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5 10" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GMPS ATP-PPase" evidence="13">
        <location>
            <begin position="242"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="225"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="269"/>
            <end position="275"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00031356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK87292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="691" mass="79736" checksum="62DAF181F0E81528" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPE8</accession>
    <name>Q5CPE8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_5500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000016">
        <property type="protein sequence ID" value="EAK87302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625314.1">
        <property type="nucleotide sequence ID" value="XM_625314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPE8"/>
    <dbReference type="STRING" id="353152.Q5CPE8"/>
    <dbReference type="GeneID" id="3375631"/>
    <dbReference type="KEGG" id="cpv:cgd6_5500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5500"/>
    <dbReference type="InParanoid" id="Q5CPE8"/>
    <dbReference type="OrthoDB" id="343001at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="294" mass="34168" checksum="44F3B040EEB23E61" modified="2005-04-12" version="1">MTNLFKKPTPGGELKPATTQLLVDDETSNQEFLVVTLEEGGEEFRIPFLVNYGTRCQPNKFERLIVLDHKSYKFYIITVNNQNSELIIDNENGRLKFIFDTHIYSINTNKILEEKLGYKKDLNQVVVKNYDYENIPNRPKYYNSKYRTLVPENFNIFRDQLCESTGQDGVDFIGVFSLIDTEIRMPPVKTNDVYEFFSIARCYATFKEIGVDKVYAVPVPRDMKCYVDNNNCTIRMVDSTDDVTYKVDSAELSIQEFKILTNNVFRFKVIIAKNLEEAMITGLSRLRGLRPDDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPH2</accession>
    <name>Q5CPH2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_70</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625321.1">
        <property type="nucleotide sequence ID" value="XM_625321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPH2"/>
    <dbReference type="GeneID" id="3372321"/>
    <dbReference type="KEGG" id="cpv:cgd3_70"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_70"/>
    <dbReference type="InParanoid" id="Q5CPH2"/>
    <dbReference type="OMA" id="KPMANES"/>
    <dbReference type="OrthoDB" id="342209at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="217" mass="25281" checksum="F24003D2F029BB10" modified="2005-04-12" version="1">MKVLDGQILKGGVISFSNESKGKSEKLLPLKIVQNKYNKHKKNEPKRKLLTPFKNESISDFCKRVDSDSRQYLMEKDREALRMQKSMKNKKKREKRSLKNLEKSQAKNTNLNEISELESNFSLNNTNRPSFGDVIDSPPLISSKIKDKLEKSKKETKTCSDLSEYVNQVRKAYSEIKMKRINESNKLFQNKKKNSERVLNDFGDGWVGIGKFRRQEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPJ5</accession>
    <name>Q5CPJ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Possible Na+/H+ and K+/H+ antiporter with 12 transmembrane domains, duplicated adjacent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd6_140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625354.1">
        <property type="nucleotide sequence ID" value="XM_625354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPJ5"/>
    <dbReference type="STRING" id="353152.Q5CPJ5"/>
    <dbReference type="GeneID" id="3375661"/>
    <dbReference type="KEGG" id="cpv:cgd6_140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_140"/>
    <dbReference type="InParanoid" id="Q5CPJ5"/>
    <dbReference type="OMA" id="GFEFEWF"/>
    <dbReference type="OrthoDB" id="441412at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF86">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="87"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="241"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="331"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="404"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="12">
        <location>
            <begin position="36"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="580"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="581"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="630"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK87330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="927" mass="102387" checksum="BB00E3C35F31C35A" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPM3</accession>
    <name>Q5CPM3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625398.1">
        <property type="nucleotide sequence ID" value="XM_625398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPM3"/>
    <dbReference type="GeneID" id="3372357"/>
    <dbReference type="KEGG" id="cpv:cgd2_290"/>
    <dbReference type="InParanoid" id="Q5CPM3"/>
    <dbReference type="OrthoDB" id="342619at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="183" mass="20904" checksum="7FCFD491AD045EAB" modified="2005-04-12" version="1">MIDFDSEDELINEETYFEEIYYGVSDRVIGECRAKDTNSPIETSMNFVKAKEKSIENRVGIQPNIMNETINETINETASKWSTRLRANSNSNTSPTLDTNSSSKSSSPRKLSKATRSRLLLKERIFSMNPFEVNINGQIETNNRHTDRYNNQISSTENHPITNVIVTQNTHVSKQPFSSLFNM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPN1</accession>
    <name>Q5CPN1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glycerol-3-phosphate dehydrogenase [NAD(+)]</fullName>
            <ecNumber evidence="9">1.1.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd2_210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 9">
            <text>sn-glycerol 3-phosphate + NAD(+) = dihydroxyacetone phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57597"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.8" evidence="9"/>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625390.1">
        <property type="nucleotide sequence ID" value="XM_625390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPN1"/>
    <dbReference type="SMR" id="Q5CPN1"/>
    <dbReference type="FunCoup" id="Q5CPN1">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPN1"/>
    <dbReference type="GeneID" id="3372365"/>
    <dbReference type="KEGG" id="cpv:cgd2_210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_210"/>
    <dbReference type="InParanoid" id="Q5CPN1"/>
    <dbReference type="OMA" id="NRMFGNM"/>
    <dbReference type="OrthoDB" id="10263760at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141152">
        <property type="term" value="F:glycerol-3-phosphate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046168">
        <property type="term" value="P:glycerol-3-phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1040.10:FF:000004">
        <property type="entry name" value="Glycerol-3-phosphate dehydrogenase [NAD(+)]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1040.10">
        <property type="entry name" value="N-(1-d-carboxylethyl)-l-norvaline Dehydrogenase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013328">
        <property type="entry name" value="6PGD_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006168">
        <property type="entry name" value="G3P_DH_NAD-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006109">
        <property type="entry name" value="G3P_DH_NAD-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017751">
        <property type="entry name" value="G3P_DH_NAD-dep_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011128">
        <property type="entry name" value="G3P_DH_NAD-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03376">
        <property type="entry name" value="glycerol3P_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11728:SF8">
        <property type="entry name" value="GLYCEROL-3-PHOSPHATE DEHYDROGENASE [NAD(+)]-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07479">
        <property type="entry name" value="NAD_Gly3P_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01210">
        <property type="entry name" value="NAD_Gly3P_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000114">
        <property type="entry name" value="Glycerol-3-P_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00077">
        <property type="entry name" value="GPDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent N-terminal" evidence="10">
        <location>
            <begin position="13"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Glycerol-3-phosphate dehydrogenase NAD-dependent C-terminal" evidence="11">
        <location>
            <begin position="205"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="216"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="18"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="106"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="283"/>
            <end position="284"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="283"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000114-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK87381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="416" mass="46077" checksum="9CFAD9998DB3A140" modified="2005-04-12" version="1">MCLRQHLRCSSLKVTIFGAGSFGSAISCVVGYNTERTLIFNSEVKLWLYDERLESGEYLADVINRDHVNVKYLPDFKLPNNIRAVTDLKEACEDCNLMIFVIPSQFIRSVASQIRKLDIDFSRAVRAVSLTKGFLVENGHPFLISKIIEEELGIDCCVLSGANVASGLAAKEFGEATLACSDYDDAYIWQYLFDTPWFKIDCVPDVICTELFGGLKNIIALLVGMIQGLGCGTNTVAAVMRLGVLEMILYGSIFFNIRSSIMTRVFFESCGIADLVTTCLGGRNVRGGKAFTLSNGQKPWEEIEAEVTGGQHLAGLVTLKEINETLEVLLIEKSIDVDKHFPLFRSCFKIAYTGAPPRSLIDILGRNELRELRFVPSGLLSLIDDSPNHGEVMQRSSSRQVGSLILSKTQSCMQYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPN2</accession>
    <name>Q5CPN2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible apicomplexan-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625389.1">
        <property type="nucleotide sequence ID" value="XM_625389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPN2"/>
    <dbReference type="FunCoup" id="Q5CPN2">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPN2"/>
    <dbReference type="GeneID" id="3372346"/>
    <dbReference type="KEGG" id="cpv:cgd2_200"/>
    <dbReference type="InParanoid" id="Q5CPN2"/>
    <dbReference type="OMA" id="GKNEVHI"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.340">
        <property type="entry name" value="Nucleoplasmin core domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041232">
        <property type="entry name" value="NPL"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17800">
        <property type="entry name" value="NPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoplasmin-like" evidence="2">
        <location>
            <begin position="15"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="323" mass="36572" checksum="BA93A97DA2E1AEB4" modified="2005-04-12" version="1" fragment="single">GINLQYYLILQLKMFCGLIIKPGQKVKLDSTQGEILHLSQACLSEPKDNGRVYVQAIDNGNAYTICSLQKGTIEHANLDLFLSTSAEIELSIIGKNEVHISGFYEPEMEEDFDDDDALMGMSDEEEDEEEEEEEEPELESSKIDNKKSLKRKLPSKSDESTEEEIDDEEIDSDEADDLDLDELIQDNDEDDDEDGDEDSDEDDEDDLDDLDDDEEEEEEEEEPVKAPSTKNKNKQSSTSQKTKSSDSQPPSKKSRLESKSQSKPDQLYEESIIDFLKKNGRTNMAMIGNKIKRPEGVSKKLGSFIAERTDLFKVENNMISLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPT2</accession>
    <name>Q5CPT2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Possible carboxypeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd4_4160</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625432.1">
        <property type="nucleotide sequence ID" value="XM_625432.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPT2"/>
    <dbReference type="GeneID" id="3372434"/>
    <dbReference type="KEGG" id="cpv:cgd4_4160"/>
    <dbReference type="InParanoid" id="Q5CPT2"/>
    <dbReference type="OrthoDB" id="10249045at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006518">
        <property type="term" value="P:peptide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00596">
        <property type="entry name" value="Peptidase_M14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057246">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050753">
        <property type="entry name" value="Peptidase_M14_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532:SF57">
        <property type="entry name" value="CARBOXYPEPTIDASE D, B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11532">
        <property type="entry name" value="PROTEASE M14 CARBOXYPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00132">
        <property type="entry name" value="CARBOXYPEPT_ZN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="307"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="4">
        <location>
            <begin position="1"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="5">
        <location>
            <position position="345"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="456" mass="52630" checksum="113DD8C6B5846596" modified="2013-05-29" version="2" fragment="single">KSTNITVKKDYIXGESKCQYLHIKLGISNINYDVPNILFISGIHGDEKLGVEIATEFISSICDQYINHNNIGIKYLLSTRNIWIIPIANPWGFYHNKRTEEEIDVNRDFPSKSGXNCLKSESSKMIYNLFNLKSFVFVAALHGGLKSISYGNGYFDDIDENNKXFEXIAKDLQASAGKILNNNDIHKLNYFYDQIGNIAKTVYPIKGGFEDWSLYGYNVSHILCSDYIQKSHSANKGGSLTFLIETDHQKTPNQDTLGSKSDLFSLIDLDKLSIQPSHITRNIRMLLKLTEYTYPDIIFFNKPPSTVYFGQTFILYIAIIGCYSFSNLRIKLENNNNNNXNNNNDINHYXNTXLNSEQQPIYLNFYVNEGLDGLQNTIYYKRCSSLFLNNQEIQDILDNXSFYTXXDKCNESNLLTXIVNRSFRVKNKCKSIYQFNKFXPIXILXRYRMRQQFLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPW6</accession>
    <name>Q5CPW6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625513.1">
        <property type="nucleotide sequence ID" value="XM_625513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPW6"/>
    <dbReference type="GeneID" id="3372457"/>
    <dbReference type="KEGG" id="cpv:cgd8_520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_520"/>
    <dbReference type="InParanoid" id="Q5CPW6"/>
    <dbReference type="OMA" id="ECDEMYA"/>
    <dbReference type="OrthoDB" id="344328at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="78"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="367" mass="40776" checksum="34685E9FC111975C" modified="2005-04-12" version="1">MSKIKKLLFYGYSLLSLSAIVLFSGEESHHLRKSCSFLVDEFFRSELFERKPGFSFFLEEKQTGIVFENVSLVQLSKKKKSKSKNKEEKKRKKKEEKERKKQEKEKKKQEKASAKAQAKEMKKKDKEDEREIKNLGKKDNVPSKEVSKKLKELKKQLKAERKNNPQLTLMQLFNNSGGFSGSGAANANSDTDSNSGIQDASDSITDVTAGAASTAELTKEEKKKQKKQDKKDEKELIKMMTSSGMNKKDAKKKVKELKKQLKQARKNGNPRLTLINLYNNTGGAGGAGGTGGAGTGDVIGGDVETRLSALEAKVSKLISKNKKRKDVIKRLNSNISKLAFIVKKMTRGGRAGNNGQSSASNIDDDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPW9</accession>
    <name>Q5CPW9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative large low complexity coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625510.1">
        <property type="nucleotide sequence ID" value="XM_625510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPW9"/>
    <dbReference type="STRING" id="353152.Q5CPW9"/>
    <dbReference type="GeneID" id="3372455"/>
    <dbReference type="KEGG" id="cpv:cgd8_490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_490"/>
    <dbReference type="InParanoid" id="Q5CPW9"/>
    <dbReference type="OMA" id="KQYMRLE"/>
    <dbReference type="OrthoDB" id="49058at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005814">
        <property type="term" value="C:centriole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007099">
        <property type="term" value="P:centriole replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.20">
        <property type="entry name" value="Spindle assembly abnormal protein 6, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032396">
        <property type="entry name" value="SAS-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038558">
        <property type="entry name" value="SAS-6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44281:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16531">
        <property type="entry name" value="SAS-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle assembly abnormal protein 6 N-terminal" evidence="8">
        <location>
            <begin position="161"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="765"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="825"/>
            <end position="844"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="898"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="354"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="430"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="577"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="765"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="923" mass="105852" checksum="104816D6528F2172" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPX8</accession>
    <name>Q5CPX8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625501.1">
        <property type="nucleotide sequence ID" value="XM_625501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPX8"/>
    <dbReference type="FunCoup" id="Q5CPX8">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPX8"/>
    <dbReference type="GeneID" id="3372450"/>
    <dbReference type="KEGG" id="cpv:cgd8_400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_400"/>
    <dbReference type="InParanoid" id="Q5CPX8"/>
    <dbReference type="OMA" id="YAHFPMK"/>
    <dbReference type="OrthoDB" id="10252633at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000003">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.930.12:FF:000004">
        <property type="entry name" value="60S ribosomal protein L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.930.12">
        <property type="entry name" value="Ribosomal protein L6, alpha-beta domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000702">
        <property type="entry name" value="Ribosomal_uL6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036789">
        <property type="entry name" value="Ribosomal_uL6-like_a/b-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020040">
        <property type="entry name" value="Ribosomal_uL6_a/b-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655:SF16">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11655">
        <property type="entry name" value="60S/50S RIBOSOMAL PROTEIN L6/L9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00347">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002162">
        <property type="entry name" value="Ribosomal_L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56053">
        <property type="entry name" value="Ribosomal protein L6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="12"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL6 alpha-beta" evidence="4">
        <location>
            <begin position="99"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="190" mass="21401" checksum="769BD0BA6D06179C" modified="2007-04-03" version="1">MKDIFTYESFRVMEGTTVSVKSRTVTVTGKFGQVTRSFNHLPVDIKLCGNGKVVRIEVWFGTPRHQSAINTVCSAIKNMMVGVMKKFEYKMRLVYSHFPINSNILNNGSLIEIRNFLGEKRVRTVKMLPGVVVEKSNSVKDELIITGTDLELVSRSAALIHQCALARNKDIRKFLDGIYVSEKGTVVKDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ12</accession>
    <name>Q5CQ12_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide, predicted secreted protein of cryptosprodidium-specific SKSR gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_30</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625467.1">
        <property type="nucleotide sequence ID" value="XM_625467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ12"/>
    <dbReference type="STRING" id="353152.Q5CQ12"/>
    <dbReference type="GeneID" id="3372485"/>
    <dbReference type="KEGG" id="cpv:cgd8_30"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_30"/>
    <dbReference type="InParanoid" id="Q5CQ12"/>
    <dbReference type="OrthoDB" id="344026at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253736" evidence="2">
        <location>
            <begin position="24"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="497"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="551"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="714"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="779"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="587"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="801"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="985" mass="114159" checksum="7FB2CAC239E7CABF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQK9</accession>
    <name>Q5CQK9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CCAAT-binding factor chain HAP5 like histone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NFYC/HAP5 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625639.1">
        <property type="nucleotide sequence ID" value="XM_625639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQK9"/>
    <dbReference type="STRING" id="353152.Q5CQK9"/>
    <dbReference type="GeneID" id="3372710"/>
    <dbReference type="KEGG" id="cpv:cgd4_310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_310"/>
    <dbReference type="InParanoid" id="Q5CQK9"/>
    <dbReference type="OrthoDB" id="1272441at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050568">
        <property type="entry name" value="Transcr_DNA_Rep_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252">
        <property type="entry name" value="HISTONE-LIKE TRANSCRIPTION FACTOR CCAAT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10252:SF8">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="7">
        <location>
            <begin position="153"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="342" mass="38996" checksum="48DA16860AAFA93C" modified="2005-04-12" version="1">MSFPNNQGIMDYLIQNNKEIADYNVDSMLTTQSEPQYNGMETISQVDLSDNYINDSYKSGSDTAISEFVGSHQLNQTSLSSFTLNSASYMAPSSRSTSSSSNSVISSSSLVSNSSIYSREDINIISKEYISHENQSNIPVFSKDELKTLSRCLPHTKIKKIIKCSGAVNHMIGSEVPALLAIACELFVRDLTSFSWNFTRRAKRRTVQVQDIKSVSSKDFRLKRLLYASKSQLKNISYENESLGQNKKPILNYYSGGIYPQSMQIPTSTTQSTQIYPKHFNRSQNNQQNIINKQSINRHINNYNIDQEFQKSYNLSPNQHTQYNINQFNSNNINYYNGYYHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQM2</accession>
    <name>Q5CQM2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625626.1">
        <property type="nucleotide sequence ID" value="XM_625626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQM2"/>
    <dbReference type="GeneID" id="3372718"/>
    <dbReference type="KEGG" id="cpv:cgd4_170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_170"/>
    <dbReference type="InParanoid" id="Q5CQM2"/>
    <dbReference type="OrthoDB" id="344152at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="107" mass="12925" checksum="1BE6B1437829C00E" modified="2005-04-12" version="1">MSTNQNIDIEKWQKEFFSVEKSSLPQEDTRINSSIKDERSLIEQKISEEIQTLELMNPDAFNRIPMIYEKKDPSYIEENWREYRGHLTQDYLKKSKQANRKLKKQNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQM5</accession>
    <name>Q5CQM5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">Swi2/Snf2 ATpase,Rad16 ortholog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd4_140</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625623.1">
        <property type="nucleotide sequence ID" value="XM_625623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQM5"/>
    <dbReference type="FunCoup" id="Q5CQM5">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQM5"/>
    <dbReference type="GeneID" id="3372722"/>
    <dbReference type="KEGG" id="cpv:cgd4_140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_140"/>
    <dbReference type="InParanoid" id="Q5CQM5"/>
    <dbReference type="OMA" id="DHPYLIL"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18008">
        <property type="entry name" value="DEXDc_SHPRH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.10">
        <property type="entry name" value="Zinc finger, PARP-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050628">
        <property type="entry name" value="SNF2_RAD54_helicase_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001510">
        <property type="entry name" value="Znf_PARP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036957">
        <property type="entry name" value="Znf_PARP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626:SF12">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45626">
        <property type="entry name" value="TRANSCRIPTION TERMINATION FACTOR 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01336">
        <property type="entry name" value="zf-PARP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50064">
        <property type="entry name" value="ZF_PARP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PARP-type" evidence="13">
        <location>
            <begin position="53"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="14">
        <location>
            <begin position="944"/>
            <end position="1004"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="1108"/>
            <end position="1264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="540"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1015"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="543"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="559"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="589"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="620"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK87701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1278" mass="147372" checksum="BCD26C084BACBDEF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQY0</accession>
    <name>Q5CQY0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Hexose transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd4_2870</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>D-fructose(out) = D-fructose(in)</text>
            <dbReference type="Rhea" id="RHEA:60372"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:60373"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>D-galactose(in) = D-galactose(out)</text>
            <dbReference type="Rhea" id="RHEA:34915"/>
            <dbReference type="ChEBI" id="CHEBI:4139"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="7">
            <dbReference type="Rhea" id="RHEA:34917"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>D-glucosamine(out) = D-glucosamine(in)</text>
            <dbReference type="Rhea" id="RHEA:78423"/>
            <dbReference type="ChEBI" id="CHEBI:58723"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:78424"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>D-glucose(out) = D-glucose(in)</text>
            <dbReference type="Rhea" id="RHEA:60376"/>
            <dbReference type="ChEBI" id="CHEBI:4167"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="8">
            <dbReference type="Rhea" id="RHEA:60377"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-mannose(out) = D-mannose(in)</text>
            <dbReference type="Rhea" id="RHEA:78391"/>
            <dbReference type="ChEBI" id="CHEBI:4208"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:78392"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>D-xylose(out) = D-xylose(in)</text>
            <dbReference type="Rhea" id="RHEA:78427"/>
            <dbReference type="ChEBI" id="CHEBI:53455"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:78428"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625872.1">
        <property type="nucleotide sequence ID" value="XM_625872.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQY0"/>
    <dbReference type="SMR" id="Q5CQY0"/>
    <dbReference type="STRING" id="353152.Q5CQY0"/>
    <dbReference type="GeneID" id="3372999"/>
    <dbReference type="KEGG" id="cpv:cgd4_2870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2870"/>
    <dbReference type="InParanoid" id="Q5CQY0"/>
    <dbReference type="OMA" id="GHMIWTH"/>
    <dbReference type="OrthoDB" id="6133115at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015149">
        <property type="term" value="F:hexose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045263">
        <property type="entry name" value="GLUT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005828">
        <property type="entry name" value="MFS_sugar_transport-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003663">
        <property type="entry name" value="Sugar/inositol_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503:SF8">
        <property type="entry name" value="FACILITATED GLUCOSE TRANSPORTER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23503">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00083">
        <property type="entry name" value="Sugar_tr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00171">
        <property type="entry name" value="SUGRTRNSPORT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="4 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 14" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="97"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="119"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="162"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="239"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="326"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="366"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="393"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="457"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="484"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK87821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="510" mass="57460" checksum="9D603A8243ACA284" modified="2005-04-12" version="1">MEFSLFSYSQKRILAAGVLSLLSGYVLGVTNIPRAVLLNFLSFSWMKWSMHVRGYQITNSCINFESFIMVLINSSLLLGASIGSIASVFVERYFGKVKGILSAYFLFGIGSVFCLNKDLVIFLIGRVLCGAGVGFSCNLVPSYIFELTNKQNQTLFSTLHNVLFCCGILLSYLLSIGAMYIAVYIVKFRSSINSINETEQTITNIIYHDPVSPMIQSNLGISKKTGIEFSITDHSYSILSIRILFIVPIIFSLILSLIWILKLNGDTPSHYIKLNDIRAAEETTRQIYGIFDTTRIISQLREENERESISILKLFKAISKSPMRNVFIFIPILICTEVFTGYIPLVMNSKLIISHFGIIDQVSSNYVVLTGCFLVNFTLSGVFFELYIGSKRLYILGLILVIFSYIPICSLLFFSNNLIAMSQPFIISFICVFASFGLGIVPTAWKLVSTYMTIQFYFSVTPYMSALFWITAVLSTILSELLPILVFTFINSCFSFFVLISFFIINYQNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQY7</accession>
    <name>Q5CQY7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">LITAF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd4_2800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDIP1/LITAF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625865.1">
        <property type="nucleotide sequence ID" value="XM_625865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQY7"/>
    <dbReference type="STRING" id="353152.Q5CQY7"/>
    <dbReference type="GeneID" id="3373002"/>
    <dbReference type="KEGG" id="cpv:cgd4_2800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2800"/>
    <dbReference type="InParanoid" id="Q5CQY7"/>
    <dbReference type="OMA" id="YCHQELE"/>
    <dbReference type="OrthoDB" id="5599753at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006629">
        <property type="entry name" value="LITAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037519">
        <property type="entry name" value="LITAF_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292:SF6">
        <property type="entry name" value="FI16602P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23292">
        <property type="entry name" value="LIPOPOLYSACCHARIDE-INDUCED TUMOR NECROSIS FACTOR-ALPHA FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10601">
        <property type="entry name" value="zf-LITAF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00714">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51837">
        <property type="entry name" value="LITAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="LITAF" evidence="8">
        <location>
            <begin position="18"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="378" mass="43356" checksum="645ACA622AD78D54" modified="2005-04-12" version="1">MVAQGKLIHFEVEPVKHGEEIEENSNIKFEDIPVECICPFCKEDIVTQVELESSWFTYITSVALFLIIGWISCPILPLIWTLIQDSVHTCPRCLNKISRNRRIKCPSIKSEIMTLKCGSCAVVLTRRYVITIFLIFFTIIVFTTLRTLLKIYGLPDIEHGPPIENSWMMFIESCGVKSYLGNPIRAVREFEDSYKYKTVSWTGRVIKVQEGFWKKHFIYIGMNPPQIVTNSGNPIPDLGLTFNEDLLPQISKIKPGDLLDFNATLVEFGKRGHPHFGQMWNFTKLDDEFNMIDILLPRQKSLLLMIPLIEMMNQLSEQLSKPIGSEDQDKHPSGHEGILNSNIQDISEFDIAKRLHDETYRLPESSSSSIDDSEKIDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR31</accession>
    <name>Q5CR31_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625821.1">
        <property type="nucleotide sequence ID" value="XM_625821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR31"/>
    <dbReference type="GeneID" id="3372891"/>
    <dbReference type="KEGG" id="cpv:cgd4_2330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2330"/>
    <dbReference type="InParanoid" id="Q5CR31"/>
    <dbReference type="OrthoDB" id="340448at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="104" mass="12145" checksum="562D3286E84A4EE8" modified="2005-04-12" version="1">MSDASIDWKFSIGFYAAIFVALLPTGISLTYWYEGVLWHNVFEQDRLQWQPERNDAQNFTNGNQYNYIQVPTDFNSVMGGLQSPSEMARTIERNIEKKQMNEQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRD4</accession>
    <name>Q5CRD4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Secreted lipopolysaccharide sugar transferase like family 8 glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_3250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626252.1">
        <property type="nucleotide sequence ID" value="XM_626252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRD4"/>
    <dbReference type="GeneID" id="3373215"/>
    <dbReference type="KEGG" id="cpv:cgd5_3250"/>
    <dbReference type="InParanoid" id="Q5CRD4"/>
    <dbReference type="OMA" id="SNIINDW"/>
    <dbReference type="OrthoDB" id="6238971at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="158" mass="18873" checksum="F9526A6A2CF26B6A" modified="2005-04-12" version="1" fragment="single">LIYIFVFFNKSKYFRQLFKTEIKSECGIVARSSTNSNIINDWLKKDELIDHLQYKASRSFNAGVLLLSLKKLRENNFVNNTLSLVQKWGINDQIALNIYCNGTYDELPMDYNFWAGRDDWKDTMRHKIVHFAGPDKPWKINYQPYEEQVSFKFFNIFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRF8</accession>
    <name>Q5CRF8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_2930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626228.1">
        <property type="nucleotide sequence ID" value="XM_626228.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRF8"/>
    <dbReference type="GeneID" id="3373243"/>
    <dbReference type="KEGG" id="cpv:cgd5_2930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2930"/>
    <dbReference type="InParanoid" id="Q5CRF8"/>
    <dbReference type="OMA" id="MICEILY"/>
    <dbReference type="OrthoDB" id="342531at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007015">
        <property type="entry name" value="DNA_pol_V/MYBBP1A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213:SF2">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13213">
        <property type="entry name" value="MYB-BINDING PROTEIN 1A FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04931">
        <property type="entry name" value="DNA_pol_phi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="600"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="915"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="977"/>
            <end position="1038"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="612"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="917"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="986"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1429" mass="163589" checksum="9D887F9E0573F706" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRP6</accession>
    <name>Q5CRP6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_1980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626140.1">
        <property type="nucleotide sequence ID" value="XM_626140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRP6"/>
    <dbReference type="GeneID" id="3373267"/>
    <dbReference type="KEGG" id="cpv:cgd5_1980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1980"/>
    <dbReference type="InParanoid" id="Q5CRP6"/>
    <dbReference type="OMA" id="HILIMNI"/>
    <dbReference type="OrthoDB" id="342463at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="99"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="681"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="286"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="882" mass="102159" checksum="CCDF37CC084733BB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRZ6</accession>
    <name>Q5CRZ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VirR/VirH family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626040.1">
        <property type="nucleotide sequence ID" value="XM_626040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRZ6"/>
    <dbReference type="GeneID" id="3373301"/>
    <dbReference type="KEGG" id="cpv:cgd5_880"/>
    <dbReference type="InParanoid" id="Q5CRZ6"/>
    <dbReference type="OMA" id="EKINMHE"/>
    <dbReference type="OrthoDB" id="4882at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09281">
        <property type="entry name" value="UPF0066"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="entry name" value="YaeB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00104">
        <property type="entry name" value="tRNA_TsaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818">
        <property type="entry name" value="TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818:SF0">
        <property type="entry name" value="TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="YaeB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="3">
        <location>
            <begin position="141"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="379" mass="43998" checksum="B7C0C71A2EC242B1" modified="2005-04-12" version="1" fragment="single">ELNFKIPSNIVLNEQIRLVAPKRREYGDLSTNIIIKLERWLKLECNADEFELKKEKLSADFLSEKLIEKIVAIIINDFKQGEDSDIYLFKGTSNSNNTEVRFKIENRSRGFINFYIVSDVYNKKIVEDLIITKNDIQFFPVRTIGYCYSCWTEKFGVPRQSVLVPSSRGVIQLLPEFNSDFIFGLDEFSHLWIIFIFDDVPQDITINSKIRPPGMNGKSTGVYSTRTPHRVNRIGISNVKIESISGNRIFISGIDLLNGTPIIDIKPYHICDIIDKEELLCPRWVVDNIEGQFKVSIPNEILNKLDKITEKNGLLSQEKINMHEKKLNELRSFGGKWPFIFFKSRIEFLETVTQSLSYDVRCRQRKINEVSIFALKIIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS78</accession>
    <name>Q5CS78_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Domain KOG1015, transcription regulator XNP/ATRX, DEAD-box superfamily, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_3780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628189.1">
        <property type="nucleotide sequence ID" value="XM_628189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS78"/>
    <dbReference type="STRING" id="353152.Q5CS78"/>
    <dbReference type="GeneID" id="3371509"/>
    <dbReference type="KEGG" id="cpv:cgd1_3780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3780"/>
    <dbReference type="InParanoid" id="Q5CS78"/>
    <dbReference type="OMA" id="KEITEWI"/>
    <dbReference type="OrthoDB" id="343091at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253790" evidence="2">
        <location>
            <begin position="23"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="204"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="414"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="510"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="814" mass="92018" checksum="1B6474BE21BE1980" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSM0</accession>
    <name>Q5CSM0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd1_2130</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Gln) + L-glutamine + ATP = L-glutaminyl-tRNA(Gln) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20121"/>
            <dbReference type="Rhea" id="RHEA-COMP:9662"/>
            <dbReference type="Rhea" id="RHEA-COMP:9681"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78521"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.18" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628047.1">
        <property type="nucleotide sequence ID" value="XM_628047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSM0"/>
    <dbReference type="FunCoup" id="Q5CSM0">
        <property type="interactions" value="493"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSM0"/>
    <dbReference type="GeneID" id="3371682"/>
    <dbReference type="KEGG" id="cpv:cgd1_2130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2130"/>
    <dbReference type="InParanoid" id="Q5CSM0"/>
    <dbReference type="OMA" id="LCAREDM"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004819">
        <property type="term" value="F:glutamine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006425">
        <property type="term" value="P:glutaminyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000037">
        <property type="entry name" value="Glutamine--tRNA ligase cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004514">
        <property type="entry name" value="Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00440">
        <property type="entry name" value="glnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011291">
        <property type="entry name" value="PRK14703.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF4">
        <property type="entry name" value="GLUTAMINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 9" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="10">
        <location>
            <begin position="38"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="11">
        <location>
            <begin position="350"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="12">
        <location>
            <begin position="482"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="640" mass="74958" checksum="194DA73921E461E2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSN1</accession>
    <name>Q5CSN1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Predicted coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_2000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628036.1">
        <property type="nucleotide sequence ID" value="XM_628036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSN1"/>
    <dbReference type="STRING" id="353152.Q5CSN1"/>
    <dbReference type="GeneID" id="3371656"/>
    <dbReference type="KEGG" id="cpv:cgd1_2000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2000"/>
    <dbReference type="InParanoid" id="Q5CSN1"/>
    <dbReference type="OMA" id="QVIEPMD"/>
    <dbReference type="OrthoDB" id="277439at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006709">
        <property type="entry name" value="SSU_processome_Utp14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14150:SF12">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 14 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04615">
        <property type="entry name" value="Utp14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="697" mass="80940" checksum="4611A53C2C7989EA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSU3</accession>
    <name>Q5CSU3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">protein O-GlcNAc transferase</fullName>
            <ecNumber evidence="3">2.4.1.255</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_1300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.255" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627974.1">
        <property type="nucleotide sequence ID" value="XM_627974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSU3"/>
    <dbReference type="STRING" id="353152.Q5CSU3"/>
    <dbReference type="CAZy" id="GT41">
        <property type="family name" value="Glycosyltransferase Family 41"/>
    </dbReference>
    <dbReference type="GeneID" id="3371590"/>
    <dbReference type="KEGG" id="cpv:cgd1_1300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1300"/>
    <dbReference type="InParanoid" id="Q5CSU3"/>
    <dbReference type="OMA" id="MNESEHF"/>
    <dbReference type="OrthoDB" id="420945at2759"/>
    <dbReference type="SABIO-RK" id="Q5CSU3"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097363">
        <property type="term" value="F:protein O-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11380">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051939">
        <property type="entry name" value="Glycosyltr_41/O-GlcNAc_trsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029489">
        <property type="entry name" value="OGT/SEC/SPY_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013105">
        <property type="entry name" value="TPR_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44835:SF1">
        <property type="entry name" value="PROTEIN O-GLCNAC TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44835">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--PEPTIDE N-ACETYLGLUCOSAMINYLTRANSFERASE SPINDLY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13844">
        <property type="entry name" value="Glyco_transf_41"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07719">
        <property type="entry name" value="TPR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 8" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="374"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="8">
        <location>
            <begin position="476"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="9">
        <location>
            <begin position="672"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="domain" description="O-GlcNAc transferase C-terminal" evidence="9">
        <location>
            <begin position="815"/>
            <end position="1012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1032" mass="119182" checksum="7E6BF61E47FDE7B6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT31</accession>
    <name>Q5CT31_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted secreted protein, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627886.1">
        <property type="nucleotide sequence ID" value="XM_627886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT31"/>
    <dbReference type="GeneID" id="3371424"/>
    <dbReference type="KEGG" id="cpv:cgd1_260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_260"/>
    <dbReference type="InParanoid" id="Q5CT31"/>
    <dbReference type="OMA" id="TCELNIF"/>
    <dbReference type="OrthoDB" id="344207at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254937" evidence="1">
        <location>
            <begin position="18"/>
            <end position="461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="461" mass="52949" checksum="6E872D5EBB1A5160" modified="2005-04-12" version="1">MSLLFLTFVLIILKTHCLNSSGNLNEIEFPPSWHFFENHNSLESYKYGFFMETLLHLKKKSERDGEIFSNIMNYNIESKPCEIDEDIFNLLNNPVILVDNRTTFQKDDNTRNVLFCQEKTNIGSSKEKRKTIIRTLKLKLENGNVLRLMLNFSKIGFWIWDNNLLSKNHSNIVNRCFAVGKKDKIKILQKSLHSKIKVSELLIEVPFFKSKLFSQNMYKFIVENKIDGIIGLNDNSIQGVGIFETASKAMEPSKGRYIMSFQCSRLGDKNRANKNEDSLIFAIYNENGGESSKYEKLLSNEESGSIVKVMIDKEVKSKFNVKFSINLNIYGAIIPEIRLLQLYTILNKYAVQKGFSCETRETILGKTILCDCNFLNNKLSIKLYNNANSYSIDLSNFVINNGNDQKSCGIEIYGRKRNGIKFEENWVFGQILCSASNISRFSKTNSSSWSIGNPKFFINQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTC6</accession>
    <name>Q5CTC6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PrsW family intramembrane metalloprotease</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626543.1">
        <property type="nucleotide sequence ID" value="XM_626543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTC6"/>
    <dbReference type="GeneID" id="3373628"/>
    <dbReference type="KEGG" id="cpv:cgd2_3560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3560"/>
    <dbReference type="InParanoid" id="Q5CTC6"/>
    <dbReference type="OMA" id="YLYSEIC"/>
    <dbReference type="OrthoDB" id="343998at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026898">
        <property type="entry name" value="PrsW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13367">
        <property type="entry name" value="PrsW-protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="378"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="52385" checksum="CA5D8814E6D64586" modified="2005-04-12" version="1">MRNTSSLLHNTSINNDPYHNSVVIDINHTNIGEYVQENKKYPSNSFIILILLISTIIIINHGWYYGILLLIISISPGILIIYQFKKYIIEDEISIKTITDLFTFGAIISVSTTLLLEGLFFNYIFYFKNDNYNNYIDQFGCNIGFSLYILIILIKYIISIGIIEEACKLIGLLTIKPYIEDINYKESFISHYLKSNFGYVIAGISSSLGFAIIENIVYLSNSMESIIIMILVGIARGIISIPFHIFASGYTSILFSRQIFIQNDYYSNNNNNNNNNNNYYYYYLIYILKQIIIKFLTLLPAGILHGIYDSSLILLVLINQNYNKDEILSYNLNSTCNLNTRILKLFLTLFPLKINKLFGSFKNQNLIENSFNNCFGTFFYNLITIGFFIFAILSYFICFFLFIYNWIYLEKQNSNRRIITTTRTISRNNISNSINNINNTEIREIELTREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTE6</accession>
    <name>Q5CTE6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">APG-1 like HSP70 domain containing protein, signal peptide plus likely ER retention motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_3330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626523.1">
        <property type="nucleotide sequence ID" value="XM_626523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTE6"/>
    <dbReference type="SMR" id="Q5CTE6"/>
    <dbReference type="FunCoup" id="Q5CTE6">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTE6"/>
    <dbReference type="GeneID" id="3373768"/>
    <dbReference type="KEGG" id="cpv:cgd2_3330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3330"/>
    <dbReference type="InParanoid" id="Q5CTE6"/>
    <dbReference type="OMA" id="VNQQAHI"/>
    <dbReference type="OrthoDB" id="10262720at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034663">
        <property type="term" value="C:endoplasmic reticulum chaperone complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10230">
        <property type="entry name" value="ASKHA_NBD_HSP70_HYOU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639">
        <property type="entry name" value="HSC70CB, ISOFORM G-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45639:SF3">
        <property type="entry name" value="HYPOXIA UP-REGULATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254226" evidence="5">
        <location>
            <begin position="29"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="592"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="842"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="596"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="846"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="865"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="897"/>
            <end position="919"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="927" mass="103322" checksum="62D5BD3FA1EB3F99" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTF0</accession>
    <name>Q5CTF0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_3290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88691.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626519.1">
        <property type="nucleotide sequence ID" value="XM_626519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTF0"/>
    <dbReference type="SMR" id="Q5CTF0"/>
    <dbReference type="GeneID" id="3373769"/>
    <dbReference type="KEGG" id="cpv:cgd2_3290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3290"/>
    <dbReference type="InParanoid" id="Q5CTF0"/>
    <dbReference type="OMA" id="NGISKCK"/>
    <dbReference type="OrthoDB" id="343057at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253824" evidence="3">
        <location>
            <begin position="24"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="68"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="127"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="291"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="429"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="520"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="205"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="242"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="307"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88691.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="566" mass="63182" checksum="2BA6592CEFF7E180" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTF1</accession>
    <name>Q5CTF1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626518.1">
        <property type="nucleotide sequence ID" value="XM_626518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTF1"/>
    <dbReference type="GeneID" id="3373770"/>
    <dbReference type="KEGG" id="cpv:cgd2_3280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3280"/>
    <dbReference type="InParanoid" id="Q5CTF1"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="124" mass="14982" checksum="A54EC4954BE73A83" modified="2005-04-12" version="1">MYVHIYLYIFIYIYIYAWILNCIIEKNLNNLIYIKYDDFLSITSLIPPWYFFIFSFFFPQLYPGVLTIIFLFNKSTLTLCLFPLIIYLAVLFTLNNVSCIYPVFIYTFSNSFKLKKKRKILPVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTK1</accession>
    <name>Q5CTK1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">UDP N-acetylglucosamine transporter-like nucleotide sugar transporter with 10 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_2660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626468.1">
        <property type="nucleotide sequence ID" value="XM_626468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTK1"/>
    <dbReference type="FunCoup" id="Q5CTK1">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="GeneID" id="3373633"/>
    <dbReference type="KEGG" id="cpv:cgd2_2660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2660"/>
    <dbReference type="InParanoid" id="Q5CTK1"/>
    <dbReference type="OMA" id="AIMYVIQ"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="133"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="162"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="189"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="225"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="266"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="333"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="397"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="404"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="430" mass="47959" checksum="721BA2DDA05CF76E" modified="2005-04-12" version="1">MRSKGSSIKEKNSEYTPKDDGVLLPEKRSLFKISDNGVTVPRLELFYGYLNIPLRYISLLLLALKAVCVVLCTRLSFRFPAKDGRNYIPSVAVVCSEFIKLTVSLAMIFITTAKKDIRAFPKALYLEFVSDKFGNLIVLIPGVLFLFQNNLLYISLKRLPAALYQVMYQLKILTTTYFSVLILKRKLSLTRWFACFLLIFGVIMIPKKSKHSSTERTSGLSEFIIGLFAAFTSSFTSGLGAVVLEKVLKDTDERIHTGNGEFQTTVWGRNVILALVGIIGGVPLAYFSSKDQIAQYGVFQGFSPFVLLVICLNAGTGFVVVAVLKYADGILKCFCNALSIVLITLISWLFLGDTKMTPRFAFAATIVVCAVTIYSLDKVIPRKFYSTELFSSKLSSNNTDTFDSAEKTEQFKGLEKDPENSLLIQRDTKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTM3</accession>
    <name>Q5CTM3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ximpact ortholog conserved protein seen in bacteria and eukaryotes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_2430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the IMPACT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626446.1">
        <property type="nucleotide sequence ID" value="XM_626446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTM3"/>
    <dbReference type="STRING" id="353152.Q5CTM3"/>
    <dbReference type="GeneID" id="3373671"/>
    <dbReference type="KEGG" id="cpv:cgd2_2430"/>
    <dbReference type="InParanoid" id="Q5CTM3"/>
    <dbReference type="OMA" id="ATHNIWS"/>
    <dbReference type="OrthoDB" id="69641at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140469">
        <property type="term" value="P:GCN2-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.30">
        <property type="entry name" value="Impact, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023582">
        <property type="entry name" value="Impact"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001498">
        <property type="entry name" value="Impact_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036956">
        <property type="entry name" value="Impact_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301">
        <property type="entry name" value="IMPACT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16301:SF25">
        <property type="entry name" value="PROTEIN IMPACT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01205">
        <property type="entry name" value="Impact_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254232" evidence="2">
        <location>
            <begin position="20"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="domain" description="Impact N-terminal" evidence="3">
        <location>
            <begin position="145"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="290" mass="33396" checksum="E1E8D81B3EB0D1C7" modified="2005-04-12" version="1" fragment="single">VFCKFKLVTFFNFLIFLQSEYLDGILEIKISIPFGYPLEASSFCISSWYFDVHYLTNSEELPQSKNISLTSNTFKQLKELIETRVESKTPILFEIIDILISCNIDHEKYKTKSSIKEQRIETNHFDQFDGDKIFGVTHGEPIIDRKSVFQAHACKVETVEQVKKVIKWLLSNPKIAKATHNIWSYRIFKEKNFAEVTEGSFPIGYDIISQDHDSDGENAAGGRLQHLLEITNAKNVFVMVSRWYGGIQLGPDRFKHINNAARLILEKSGLITRSGTFYKPQSNKNKKNQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTN3</accession>
    <name>Q5CTN3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_2320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626436.1">
        <property type="nucleotide sequence ID" value="XM_626436.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTN3"/>
    <dbReference type="GeneID" id="3373511"/>
    <dbReference type="KEGG" id="cpv:cgd2_2320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2320"/>
    <dbReference type="InParanoid" id="Q5CTN3"/>
    <dbReference type="OMA" id="RCYIYAC"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd08374">
        <property type="entry name" value="C2F_Ferlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037725">
        <property type="entry name" value="C2F_Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF33">
        <property type="entry name" value="SPERM VESICLE FUSION PROTEIN FER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1659"/>
            <end position="1681"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="171"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="564"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="1436"/>
            <end position="1574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1686" mass="193497" checksum="277B73653D59606D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTN7</accession>
    <name>Q5CTN7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pp2c protein phosphatase 2C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_2280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626432.1">
        <property type="nucleotide sequence ID" value="XM_626432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTN7"/>
    <dbReference type="STRING" id="353152.Q5CTN7"/>
    <dbReference type="GeneID" id="3373514"/>
    <dbReference type="KEGG" id="cpv:cgd2_2280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2280"/>
    <dbReference type="InParanoid" id="Q5CTN7"/>
    <dbReference type="OMA" id="REWKISW"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="268"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="152"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="559" mass="62328" checksum="0BA20A992E8E9A4E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTQ7</accession>
    <name>Q5CTQ7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_2050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626412.1">
        <property type="nucleotide sequence ID" value="XM_626412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTQ7"/>
    <dbReference type="FunCoup" id="Q5CTQ7">
        <property type="interactions" value="503"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTQ7"/>
    <dbReference type="GeneID" id="3373675"/>
    <dbReference type="KEGG" id="cpv:cgd2_2050"/>
    <dbReference type="InParanoid" id="Q5CTQ7"/>
    <dbReference type="OMA" id="NTQVYGK"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03749">
        <property type="entry name" value="proteasome_alpha_type_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000016">
        <property type="entry name" value="Proteasome subunit alpha type-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035144">
        <property type="entry name" value="Proteasome_alpha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="288" mass="32767" checksum="C87CE48F99E3ACC4" modified="2005-04-12" version="1" fragment="single">YFFCSLLQQFSSCEYILFITLVFLISISIMYRNQYDTDVVTWSPQGRVFQIEYAMEAVKQGTAVVGARNDEIVVLACIKRSTSRLAGYQKKLYKIDNHIGVAVSGITADAKVICNYLRSECLNYSFTYDSPIPLNTLVNRLVLKSQVNTQEYGRRPFGVGLLLAGFDESGPHLFETCPSGNCFEYYSIAIGSRSQASKTYLEKHFKEFANCSKDQLILHTLRALRSSLSSEQEMNQENVDVAILGRNDIYNELLEEEKIKYLQIINQEQPPTIEQINESQETSSMQID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTR0</accession>
    <name>Q5CTR0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2007-03" db="PDB data bank">
            <title>Protein cgd2_2020 from Cryptosporidium parvum.</title>
            <authorList>
                <person name="Cymborowski M."/>
                <person name="Chruszcz M."/>
                <person name="Hills T."/>
                <person name="Lew J."/>
                <person name="Melone M."/>
                <person name="Zhao Y."/>
                <person name="Artz J."/>
                <person name="Wernimont A."/>
                <person name="Edwards A."/>
                <person name="Sundstrom M."/>
                <person name="Weigelt J."/>
                <person name="Bochkarev A."/>
                <person name="Arrowsmith C."/>
                <person name="Hui R."/>
                <person name="Minor W."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 2-205</scope>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626409.1">
        <property type="nucleotide sequence ID" value="XM_626409.1"/>
    </dbReference>
    <dbReference type="PDB" id="2PD0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A/B/C/D=2-205"/>
    </dbReference>
    <dbReference type="PDBsum" id="2PD0"/>
    <dbReference type="AlphaFoldDB" id="Q5CTR0"/>
    <dbReference type="SMR" id="Q5CTR0"/>
    <dbReference type="STRING" id="353152.Q5CTR0"/>
    <dbReference type="GeneID" id="3373531"/>
    <dbReference type="KEGG" id="cpv:cgd2_2020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2020"/>
    <dbReference type="InParanoid" id="Q5CTR0"/>
    <dbReference type="OMA" id="TISDAYC"/>
    <dbReference type="OrthoDB" id="415460at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CTR0"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2310.50">
        <property type="entry name" value="Protein of unknown function (DUF3228), domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021610">
        <property type="entry name" value="DUF3228"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38666">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38666:SF2">
        <property type="entry name" value="FLAGELLAR ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11539">
        <property type="entry name" value="DUF3228"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="3" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="2PD0"/>
        </source>
    </evidence>
    <sequence length="205" mass="23920" checksum="163F7A15D1EA5E4F" modified="2005-04-12" version="1">MKLLGVNSFALRQFVEGYRGSYIPRMSPYEFLRNVNNYIIENNPTLVDGYADFCKHIFIPNFTEAKQSIVKITNENEKYIKTGYISRRDEEIPVLSRWFPKDSPPASQLIKSKYLDIILYSKEQCEKESSIMNCCLQDILDDREKNPDWYIISIKAQNESFEVPMEPITILRNTLIEEGGSGVPLKREKYLESVEFWKEHAIVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTR5</accession>
    <name>Q5CTR5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SAP+PHD+MIZ domains containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_1950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626404.1">
        <property type="nucleotide sequence ID" value="XM_626404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTR5"/>
    <dbReference type="STRING" id="353152.Q5CTR5"/>
    <dbReference type="GeneID" id="3373734"/>
    <dbReference type="KEGG" id="cpv:cgd2_1950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1950"/>
    <dbReference type="InParanoid" id="Q5CTR5"/>
    <dbReference type="OMA" id="NHEYPRI"/>
    <dbReference type="OrthoDB" id="28127at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061665">
        <property type="term" value="F:SUMO ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16650">
        <property type="entry name" value="SP-RING_PIAS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782:SF4">
        <property type="entry name" value="TONALLI, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10782">
        <property type="entry name" value="ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02891">
        <property type="entry name" value="zf-MIZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51044">
        <property type="entry name" value="ZF_SP_RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="6">
        <location>
            <begin position="393"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="634"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="635"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="659" mass="75760" checksum="38814EE60BA555EE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTW4</accession>
    <name>Q5CTW4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Calcium-dependent protein kinase 1</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="34" type="ORF">cgd2_1300</name>
    </gene>
    <organism evidence="34 35">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="34 35" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="35">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Host cell membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Parasitophorous vacuole membrane</location>
            <topology evidence="28">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="34">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626355.1">
        <property type="nucleotide sequence ID" value="XM_626355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTW4"/>
    <dbReference type="SMR" id="Q5CTW4"/>
    <dbReference type="FunCoup" id="Q5CTW4">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTW4"/>
    <dbReference type="GeneID" id="3373577"/>
    <dbReference type="KEGG" id="cpv:cgd2_1300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1300"/>
    <dbReference type="InParanoid" id="Q5CTW4"/>
    <dbReference type="OMA" id="TCVAYQL"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020005">
        <property type="term" value="C:symbiont-containing vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000398">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="17 30" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="16" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="23" id="KW-0966">Cell projection</keyword>
    <keyword evidence="20" id="KW-0969">Cilium</keyword>
    <keyword evidence="18" id="KW-0282">Flagellum</keyword>
    <keyword evidence="7" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="19" id="KW-1043">Host membrane</keyword>
    <keyword evidence="15 34" id="KW-0418">Kinase</keyword>
    <keyword evidence="24" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="21" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0519">Myristate</keyword>
    <keyword evidence="14 30" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-0564">Palmitate</keyword>
    <keyword evidence="9" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="35" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="32">
        <location>
            <begin position="185"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="33">
        <location>
            <begin position="490"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="33">
        <location>
            <begin position="527"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="33">
        <location>
            <begin position="563"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="33">
        <location>
            <begin position="601"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="31">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="binding site" evidence="30">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00060437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00068067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="33">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="EMBL" id="EAK88834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="35">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="677" mass="76620" checksum="C23EBAE5CED2C780" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTX4</accession>
    <name>Q5CTX4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Steroid reductase like intregral membrane protein with 4x transmembrane domains and an ubiquitin domain at its N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd2_1200</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the steroid 5-alpha reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626345.1">
        <property type="nucleotide sequence ID" value="XM_626345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTX4"/>
    <dbReference type="FunCoup" id="Q5CTX4">
        <property type="interactions" value="28"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTX4"/>
    <dbReference type="GeneID" id="3373586"/>
    <dbReference type="KEGG" id="cpv:cgd2_1200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1200"/>
    <dbReference type="InParanoid" id="Q5CTX4"/>
    <dbReference type="OMA" id="ATMPIFN"/>
    <dbReference type="OrthoDB" id="540503at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016627">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-CH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01801">
        <property type="entry name" value="Ubl_TECR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039357">
        <property type="entry name" value="SRD5A/TECR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556">
        <property type="entry name" value="3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10556:SF28">
        <property type="entry name" value="VERY-LONG-CHAIN ENOYL-COA REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="167"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="199"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="11">
        <location>
            <begin position="16"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="309" mass="36346" checksum="167298A143846412" modified="2005-04-12" version="1">MDMDSTMEESQSDSIIRIYVKKRSGKHLAVLNIDKDATVSDLKLQFYEEFHYYPERQWFNVASSNGEVLKEGKLEDYGIENGTTLYFKDLGVQISWRLVFFIEYLGPIIIFPIFYFFPTLIYGEPAPPKSISQKLTFALALCHYIKREIETCFVHRFSNATMPIIRLPINCFHYWFIFGASVGYYTFHPKFSPPEFSPVTLYFIAILMCVFESLNFNSHLVLRKLRDRGTKKRGIPYGSGFDLVSCANYFWETLSWICFSFIANCATCWLYTLIAFIQMSQWALKKHRNYHKEFANYPKHRKAIVPFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTZ3</accession>
    <name>Q5CTZ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626326.1">
        <property type="nucleotide sequence ID" value="XM_626326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTZ3"/>
    <dbReference type="GeneID" id="3373602"/>
    <dbReference type="KEGG" id="cpv:cgd2_950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_950"/>
    <dbReference type="InParanoid" id="Q5CTZ3"/>
    <dbReference type="OMA" id="NEYIFLH"/>
    <dbReference type="OrthoDB" id="338543at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="437" mass="52559" checksum="99169CA66B2DCB73" modified="2005-04-12" version="1">MIVDLELYPKQSLRLLLFINEQEKQSKKSTKFLEYCNEEEVKEFQYLDEEDRIIISESFREVVRAEIREYIDLYMEQYQEPLNDKEALDINEKQYTVYGNFQLFNEQKDTILWDLLTLLIYLDSMNPQIWDRRAVLIGELLQRIGLESEYMRFLSSELNLTKLALCHTFKYGEIWSYLEYILTEYYERIKGNEFKSLNNDEIINYVLKDNFEFICLQIDSYEHNYHAWSLVNWLIYELIPTIISSDDSNKPYKYNEIRMIESWVIKLLQRHPSHYGGYHALVNLNESKINSQSKSNKLEVCTVIGLVYPEEIINMLRVIIECFDHHLINCFSVILGFRYANFMLLIDSVDERSHLEIFENEIMWFQKQDLVEKMSKSPKHLEELREHFYSILSEISSYNYNKSIIQKFYDLLDSEIQIIRQESTLFYNSDCSYKGLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU08</accession>
    <name>Q5CU08_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bacterial surface antigen (D15) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_770</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626311.1">
        <property type="nucleotide sequence ID" value="XM_626311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU08"/>
    <dbReference type="STRING" id="353152.Q5CU08"/>
    <dbReference type="GeneID" id="3373374"/>
    <dbReference type="KEGG" id="cpv:cgd2_770"/>
    <dbReference type="InParanoid" id="Q5CU08"/>
    <dbReference type="OMA" id="MIGTNVN"/>
    <dbReference type="OrthoDB" id="1724197at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019867">
        <property type="term" value="C:outer membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.50">
        <property type="entry name" value="membrane protein fhac: a member of the omp85/tpsb transporter family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000184">
        <property type="entry name" value="Bac_surfAg_D15"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01103">
        <property type="entry name" value="Omp85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bacterial surface antigen (D15)" evidence="3">
        <location>
            <begin position="68"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="450" mass="50454" checksum="14E1CB5BDB9674FF" modified="2005-04-12" version="1">MKAKNVQEELSSLDAFSSVSHNVTPNTGNPLDIDVVFKLRENKKRFTLGSTINRRGKIGFEASAFFPNLFGTLSTSKFSIATFGTSSRELSISHFTPKIFSTNIDMLYNLSKSIVDYNKSSSYTENSFGGLVRFSGPNNHHNLTVESRIREFPRLLHEQIGERLQDCDTDSSNRFFGQSIQTLKNSICYSWNKIKSNHYNEKEEDSSEAETEKRSNAFYKINSNHTIKQLSIELAGFNGDVSFIKTQGFYTWSSKFSRNRYGFNFLKNPSLDFCLGFGALLPNFINKSIFKASMHDKFFLGGNCGAHYCLPGFAPRSVGPCTRITRAQGKEEDSKIVENRENVYLGGDSFIASEVRISHPLDLSGMGTDVKPDVQAFVGGAIVLDRNDNKEKRSVLEKFRQNIRVTTGIGLSVPLGPADLSLLFSAPIKYRNTDMLEGFQLGMRMTYAPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU12</accession>
    <name>Q5CU12_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BAR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626307.1">
        <property type="nucleotide sequence ID" value="XM_626307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU12"/>
    <dbReference type="GeneID" id="3373377"/>
    <dbReference type="KEGG" id="cpv:cgd2_720"/>
    <dbReference type="InParanoid" id="Q5CU12"/>
    <dbReference type="OMA" id="YIFTHYE"/>
    <dbReference type="OrthoDB" id="341388at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="34630" checksum="17A8E2DA24154B17" modified="2005-04-12" version="1">MQIAVDKSITSVTNLCYSRELILNGIGNLFPQEAIEYGSLMNSMECMGGLTTAREHFNVDCDQVKILIQEMVLSVNSIQKRLVKRRIAYSERIHYEKKLKKRQQRMNSGKSISLNDNVKLDRTQRKCGDALDEFTRIDDDVQQELQQFLTRSHEISLNIISKYNYAVGSFFSFVYSHYDNMVNGEIPTNNLMIPDQPQVSITNSNSTPNADLVVSPGKVSGTAMNSATSVSTSSSNQVQSTPNLRQTGNTSMGTINSQKMDSSETLTRPASTSTLKKSDSGCFSGVEFASRRNTKSMHQNSSSMEINLNKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU89</accession>
    <name>Q5CU89_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ATPase AAA-type core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_3780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626925.1">
        <property type="nucleotide sequence ID" value="XM_626925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU89"/>
    <dbReference type="GeneID" id="3373853"/>
    <dbReference type="KEGG" id="cpv:cgd3_3780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3780"/>
    <dbReference type="InParanoid" id="Q5CU89"/>
    <dbReference type="OMA" id="MDYITIF"/>
    <dbReference type="OrthoDB" id="344212at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="3">
        <location>
            <begin position="749"/>
            <end position="807"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="808" mass="95416" checksum="B17E67601AC79098" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUA1</accession>
    <name>Q5CUA1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_3640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626913.1">
        <property type="nucleotide sequence ID" value="XM_626913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUA1"/>
    <dbReference type="GeneID" id="3373860"/>
    <dbReference type="KEGG" id="cpv:cgd3_3640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3640"/>
    <dbReference type="InParanoid" id="Q5CUA1"/>
    <dbReference type="OMA" id="NIRETCI"/>
    <dbReference type="OrthoDB" id="337322at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253856" description="Protein kinase domain-containing protein" evidence="1">
        <location>
            <begin position="31"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="768" mass="89933" checksum="56AB790AB54BA05D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUB4</accession>
    <name>Q5CUB4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_3490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626900.1">
        <property type="nucleotide sequence ID" value="XM_626900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUB4"/>
    <dbReference type="GeneID" id="3374114"/>
    <dbReference type="KEGG" id="cpv:cgd3_3490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3490"/>
    <dbReference type="InParanoid" id="Q5CUB4"/>
    <dbReference type="OMA" id="QIFRASA"/>
    <dbReference type="OrthoDB" id="340623at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="711" mass="83209" checksum="89CAEC5F31BF523C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUD5</accession>
    <name>Q5CUD5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_3280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626879.1">
        <property type="nucleotide sequence ID" value="XM_626879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUD5"/>
    <dbReference type="GeneID" id="3373872"/>
    <dbReference type="KEGG" id="cpv:cgd3_3280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3280"/>
    <dbReference type="InParanoid" id="Q5CUD5"/>
    <dbReference type="OrthoDB" id="337796at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="374" mass="43366" checksum="393E17FCA12704F8" modified="2005-04-12" version="1">MSIGSFVPEVIFMDNIESNIKLLTENENSNNQIECISKENFLNLNSQFKQSSDSLSFDMKIRTENINLNSIQEPSKVDHYYKIQPLQGIEQNIGENIQIPVEDEVQSYTSYSNFKLEWDHENKALFVVIPSVDSLDHWMMLFLQPLGITCDSLSLNNCCLKRNCDFRIRLDDERLLLYPDLLKDISDFLSTQYLNWQYYRENVIMRDCEVMDSEQEKYIGDNLINGNHFGPKCYNYWKFPDINVFVNNDSHLNNEINFAEDENSSKFYEKENFSQNNGSFERNIQKSITNYNTDIYGKCLLVPELCSKGDEPLVQNNTLSCLTTNISDLNVLTTDSGVLQVLTSENSNHDDNYFALNTNSSMGTNDKEYFPIET</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUI8</accession>
    <name>Q5CUI8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_2660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626826.1">
        <property type="nucleotide sequence ID" value="XM_626826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUI8"/>
    <dbReference type="GeneID" id="3373968"/>
    <dbReference type="KEGG" id="cpv:cgd3_2660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2660"/>
    <dbReference type="InParanoid" id="Q5CUI8"/>
    <dbReference type="OMA" id="LELHIYL"/>
    <dbReference type="OrthoDB" id="340568at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="203" mass="23252" checksum="F7373CA15096948D" modified="2005-04-12" version="1">MVVHTEIIQTSNLDLAKQILSEEHEISGEIFWSLLFWKMPELFFLSVSKSTQISKEQLSNSLNKIILNDFRDAFNSIIIILAKLTDLIEIQTILPNESNSLNNTSIPNLTEVIFLYTTIIYTIFPYFNEEISLIESQGIQLLPLLSKAKKTVNKFSLIYKDLDRIIEKISQIHEIKRGLLKGVLSGIANQITQVPIIKQLTFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUN7</accession>
    <name>Q5CUN7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Large protein with 8 or more transmembrane domains within NH2 region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd3_2080</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626777.1">
        <property type="nucleotide sequence ID" value="XM_626777.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3374045"/>
    <dbReference type="KEGG" id="cpv:cgd3_2080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2080"/>
    <dbReference type="InParanoid" id="Q5CUN7"/>
    <dbReference type="OMA" id="ICPSIIY"/>
    <dbReference type="OrthoDB" id="433309at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003929">
        <property type="entry name" value="K_chnl_BK_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03493">
        <property type="entry name" value="BK_channel_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="282"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="427"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="455"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="483"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="14">
        <location>
            <begin position="436"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Calcium-activated potassium channel BK alpha subunit" evidence="13">
        <location>
            <begin position="868"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="189"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1091"/>
            <end position="1116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK89096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1779" mass="203660" checksum="59054301B747407E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUU6</accession>
    <name>Q5CUU6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">THO1-MOS11 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626718.1">
        <property type="nucleotide sequence ID" value="XM_626718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUU6"/>
    <dbReference type="GeneID" id="3373977"/>
    <dbReference type="KEGG" id="cpv:cgd3_1430"/>
    <dbReference type="InParanoid" id="Q5CUU6"/>
    <dbReference type="OrthoDB" id="445357at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052240">
        <property type="entry name" value="SAP_domain_ribonucleoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46551:SF1">
        <property type="entry name" value="SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="50"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="72"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="124" mass="14372" checksum="C56A4A177947E51D" modified="2005-04-12" version="1">MTNSSNEVKTDQGEKNVSISEPVRQTICISDVNQLSEKERVELRRQKFGACGPSTEAEKRLARSKRFGSTSEDDKRKLRQERFGMISEADKIKNRRERFGTMSRVNDPDHEKKIQARKLRFGLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUV2</accession>
    <name>Q5CUV2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">IQ calmodulin-binding motif family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626712.1">
        <property type="nucleotide sequence ID" value="XM_626712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUV2"/>
    <dbReference type="GeneID" id="3373982"/>
    <dbReference type="KEGG" id="cpv:cgd3_1370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1370"/>
    <dbReference type="InParanoid" id="Q5CUV2"/>
    <dbReference type="OMA" id="NCIDESI"/>
    <dbReference type="OrthoDB" id="338598at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="469"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="488" mass="56083" checksum="1A875ACF5C70D0DB" modified="2005-04-12" version="1">MLINNENVRAEEENGRRPTRNETIVYKIVNYMSSLIGGINDNVGRNNPCIGILSPMSPVMITDHVKTVGNTMVLPSPEPIIQMIPNQNLRNNMFFNVYSNDKKYVHKFGPKVTPYTNLNNGLLAINEKGDQIVTGNISLMSSPTDMCLNSSRNKLINPSSYFSRLRNPISECGGLVKSPINSCFSGQINKANESSITEILVSPELAQTLQQIISIISHQIEIDDSENFININNIKGSVKINRFQRINKKSTIGGLNYALMSYSASIIQKHFRNFDNNRMVRYINPVTRSKFSKNQIMNAIHIIQRYWRIYMYRNQIMRELLIKNVMTARNAASCKIASLWKGYKTRKFMDSIIKDVYIKWIWNNDDSANNNCSSEISNTQNYEYSKYEVKLRGSFTCKPWQEHLKLNWDNQENCFLINICLTKGAHYLQFIINDEIKACGSMEIVVLPIIGVSNKINIVGESYKSSRKFILLSYQLTHFLLFFIFIFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUV7</accession>
    <name>Q5CUV7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626707.1">
        <property type="nucleotide sequence ID" value="XM_626707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUV7"/>
    <dbReference type="GeneID" id="3373986"/>
    <dbReference type="KEGG" id="cpv:cgd3_1320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1320"/>
    <dbReference type="InParanoid" id="Q5CUV7"/>
    <dbReference type="OMA" id="LFILEIM"/>
    <dbReference type="OrthoDB" id="342095at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="199" mass="22054" checksum="D7794FCD5BDFD932" modified="2005-04-12" version="1">MVGDGFDELSPGSSQTSNEDVFNMDEEMEYSGAVKDYSMNTTSSRVVENEDSGILSNEMVDLVLDYISYKAGEGSNVTGIEKVDSTIQNCRNSGFKKSIILSYLVSSGYLDLNEGVENGEPIEDSLSYIQSMLHQKSKYIPENIEEITLAISSATKLFILELMAKINKQLNDSGSNKRVITTKHVYDAYISQEKLIPDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV47</accession>
    <name>Q5CV47_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RCC1 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626617.1">
        <property type="nucleotide sequence ID" value="XM_626617.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV47"/>
    <dbReference type="GeneID" id="3374002"/>
    <dbReference type="KEGG" id="cpv:cgd3_310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_310"/>
    <dbReference type="InParanoid" id="Q5CV47"/>
    <dbReference type="OMA" id="TCFHAET"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051210">
        <property type="entry name" value="Ub_ligase/GEF_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870:SF408">
        <property type="entry name" value="OS09G0560450 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22870">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="11"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="3">
        <location>
            <begin position="32"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="59"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="117"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="185"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="238"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="291"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="343"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="507"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="568"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="631"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="684"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="846"/>
            <end position="903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1878" mass="212627" checksum="E584C9442BA4DEB5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV53</accession>
    <name>Q5CV53_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_5380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627416.1">
        <property type="nucleotide sequence ID" value="XM_627416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV53"/>
    <dbReference type="GeneID" id="3374218"/>
    <dbReference type="KEGG" id="cpv:cgd8_5380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5380"/>
    <dbReference type="InParanoid" id="Q5CV53"/>
    <dbReference type="OMA" id="QHHEHER"/>
    <dbReference type="OrthoDB" id="10267061at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254266" evidence="2">
        <location>
            <begin position="24"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="268" mass="29076" checksum="A6616FA3402FA739" modified="2005-04-12" version="1">MCTKQSLLVFFIILNVFLQLSENGDRLSLLYGFSIIGLRSAGGCGFRKLFCLGSGDYGEGRLHPTLGPTVDGLRISSPIISKTQSTTAPPSPFPPPSPPPSPLPPPLPPKVRVKKGPSGGSQSQTPSFPLSLPCDETIPGSNLGKCTGNGSKEPSSTDGHLGGRPGSTVSPPPLRVPSLYDNVSDGNVEDSEDGAPKKPPLPANWRLPLNNENHNRASHHHHHHHHQHQHQHQHQHHHHHHHHHQDDCGDGSRPPQKPHLPVGFRLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVE3</accession>
    <name>Q5CVE3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SNW family nuclear protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_4380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNW family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627326.1">
        <property type="nucleotide sequence ID" value="XM_627326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVE3"/>
    <dbReference type="FunCoup" id="Q5CVE3">
        <property type="interactions" value="411"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVE3"/>
    <dbReference type="GeneID" id="3374531"/>
    <dbReference type="KEGG" id="cpv:cgd8_4380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4380"/>
    <dbReference type="InParanoid" id="Q5CVE3"/>
    <dbReference type="OMA" id="YGQRRGW"/>
    <dbReference type="OrthoDB" id="666364at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017862">
        <property type="entry name" value="SKI-int_prot_SKIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004015">
        <property type="entry name" value="SKI-int_prot_SKIP_SNW-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12096">
        <property type="entry name" value="NUCLEAR PROTEIN SKIP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02731">
        <property type="entry name" value="SKIP_SNW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SKI-interacting protein SKIP SNW" evidence="3">
        <location>
            <begin position="87"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="202"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="431" mass="50310" checksum="857B720A7187F876" modified="2005-04-12" version="1">MKKNQLALELHKSANITDLSVLEDEKKLVRFGNSGKLKHRGEHLKRPTESEELEIYEKTKKALNLVIDRKQDTLYPFKESKKEAKTEFIKYRSSSDTIGYDPRFAERIIKVVERPKDPLELPKFKNRILGGTKREEMVPILRPPSKKLTQEEIKEWNIPPSISNWKNPMGYTVPLDKRVQADTRDLINISVNDRFATLSESLQLAEKNAREQIKLRNELQKQKKIREEMEREEKLRKLAESSRYERSSHHLLSKIPEFYQDKKEGSDEDNDEFDHIRRIELEKRREIEREFRQERAGKKSKTLRDSDRDISEHIALGQAQSANIGSSSESQFDARLFNKVSGLDSGFSNDTISVYDKPLFNTNNLKHRGLYTFEESRVEESIGGRVHVPSFSGTDNSKTALRTKPVEFERDEDDPFGLDKLIDSVRKDYKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVH4</accession>
    <name>Q5CVH4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Aps1p/AP17 like clathrin adaptor protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_4040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">Clathrin-coated vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627295.1">
        <property type="nucleotide sequence ID" value="XM_627295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVH4"/>
    <dbReference type="FunCoup" id="Q5CVH4">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVH4"/>
    <dbReference type="GeneID" id="3374614"/>
    <dbReference type="KEGG" id="cpv:cgd8_4040"/>
    <dbReference type="InParanoid" id="Q5CVH4"/>
    <dbReference type="OMA" id="KAYHILD"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035615">
        <property type="term" value="F:clathrin adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016482">
        <property type="term" value="P:cytosolic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14831">
        <property type="entry name" value="AP1_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000007">
        <property type="entry name" value="AP complex subunit sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044733">
        <property type="entry name" value="AP1_sigma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="10">
        <location>
            <begin position="20"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="201" mass="23295" checksum="FFD8ECE05C338463" modified="2005-04-12" version="1" fragment="single">KKKKKDTYKYICIFSFKVIMFRFFLLISRQGKTRLEKWYSSYQQSERKRFIKEVTQMIINRQGKLCNFIDWKGHTLVVKRYASLYFVACIDKNDNELLALEIIHHYVEVLDRYFGNVCELDLIFNFHKAYFILDEIILAGEIEESSKKAALRVISTQDSMMDENKDHGNIILNGSSVGVSISTPNIALSAVNAAKRAGALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVI6</accession>
    <name>Q5CVI6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Na-dependent inorganic phosphate cotransporter with 12 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_3910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627283.1">
        <property type="nucleotide sequence ID" value="XM_627283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVI6"/>
    <dbReference type="STRING" id="353152.Q5CVI6"/>
    <dbReference type="GeneID" id="3374259"/>
    <dbReference type="KEGG" id="cpv:cgd8_3910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3910"/>
    <dbReference type="InParanoid" id="Q5CVI6"/>
    <dbReference type="OMA" id="LITFWMP"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050382">
        <property type="entry name" value="MFS_Na/Anion_cotransporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662:SF399">
        <property type="entry name" value="FI19708P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11662">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="361"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="418"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="448"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="477"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="511"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="557"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="92"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="609" mass="68401" checksum="04D8081B447097D6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVK6</accession>
    <name>Q5CVK6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627263.1">
        <property type="nucleotide sequence ID" value="XM_627263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVK6"/>
    <dbReference type="GeneID" id="3374312"/>
    <dbReference type="KEGG" id="cpv:cgd8_3710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3710"/>
    <dbReference type="InParanoid" id="Q5CVK6"/>
    <dbReference type="OMA" id="NSKSKCY"/>
    <dbReference type="OrthoDB" id="342428at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="401" mass="46698" checksum="298E97AAC72B6D7B" modified="2005-04-12" version="1">MNRLTENDQELKTILDGVMINDCIKPFRKVSEKLEEFDQFATEYGNSLDSKINQMLISLRKDEINCLKLEMRLEKILELVTEQMRKGNHEGKEDKAPTKNMVKTEEINKKIKKSDEKQKESGEERTLSSSMNSMESVPVDPLIKRTLEFENTQRKIYENPNNTKGCSMHVEEETCDEISVKISTDGSARSLLSKYINGENKHGNEVREKDPNAIRREKVDNIKRTVKPIARDNGNKGKCCAFWKKWCCCCLSDKGPTKSGNYYKMSIQEWKDFLASIEPKDKRYKDYCNMLEKRNDSYNVDIEGLPPLIVEYSSLNAKAGGNYYGNQMYNMGQNYQYYYPVNNQGYYNYGQYYYDARSQVSNMSYVNNNPNYLNFNKKGKNMQEDVKCRQMVHTKMGIRNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVM2</accession>
    <name>Q5CVM2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_3540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627247.1">
        <property type="nucleotide sequence ID" value="XM_627247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVM2"/>
    <dbReference type="GeneID" id="3374291"/>
    <dbReference type="KEGG" id="cpv:cgd8_3540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3540"/>
    <dbReference type="InParanoid" id="Q5CVM2"/>
    <dbReference type="OrthoDB" id="337371at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="566" mass="65301" checksum="86C16AC51F4DB713" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVR9</accession>
    <name>Q5CVR9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_3020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627200.1">
        <property type="nucleotide sequence ID" value="XM_627200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVR9"/>
    <dbReference type="GeneID" id="3374316"/>
    <dbReference type="KEGG" id="cpv:cgd8_3020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3020"/>
    <dbReference type="InParanoid" id="Q5CVR9"/>
    <dbReference type="OrthoDB" id="340433at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="301" mass="34550" checksum="DFACB53CCA31A5C7" modified="2005-04-12" version="1">MGGSFKTYTNNGKHDEISHLRYRNALEIERSNHTSELAKKAEKLRLIYKTRFEEDLRAFMVSHKAHDACLNSHAFKCINPKPLRTGSICSHKFRITSKLSHNNSEVQNSSFIPTWAWPASLRNNEDLKLISLFYTAETNVPLSPSQVGGKCNNKETQICNPIKQNTSNDKKNLLKALKISKKDEQEKLNNQNIFEPNNLKQNQRQRLRSKYGAPFTWAQNKSRDKTEVISSPLEGSSDISTPQSQVFTEIPKQPSIYPLELERNIDSHNLGISEFIKKSLKMQKTLELLLEHNTENNIKKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVS2</accession>
    <name>Q5CVS2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutathione S-transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627197.1">
        <property type="nucleotide sequence ID" value="XM_627197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVS2"/>
    <dbReference type="SMR" id="Q5CVS2"/>
    <dbReference type="GeneID" id="3374329"/>
    <dbReference type="KEGG" id="cpv:cgd8_2970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2970"/>
    <dbReference type="InParanoid" id="Q5CVS2"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="1">
        <location>
            <begin position="69"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="429" mass="49062" checksum="26846F9380622472" modified="2005-04-12" version="1">MNNKETSTIPSPNIIASKISSELSEIYSPKMSTLVRNNIPCRLTSNRVMAPSKSTYRVILPVRDIGDLSVITYEHEVYVGNGGSLRFFLLGKQVRHRFINVHLDEESPIPSYIDPNKVPLGDLPVVKLGDLVIFDEIPCLRYLAKKLGEYGRNYYIDFVIDDVIFRCSKWRDILMELISKSRKEFLINDINANKELERSTSNYKLLREQLYCEFETLILSIGDKGPFIAEKNKPMICDFILFSILFDDISLIEFNEGEKFNRTSLLPEESLIHKFPRLKMLFESVAVLPLIDQWVKGKYFSIQIEGESGELVTPPASLSTQDHVKNSVLGSNSFNAYQHSFGYQPPVLQQLPNQIFTHVNAGVRFFPQKMSLPINPSIFPTNNSFISQPITNNYHHFFNSQVQGHRYLGGVSSPFIQRVSPSQSFKLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVU0</accession>
    <name>Q5CVU0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pleckstrin homology (PH domain) containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627179.1">
        <property type="nucleotide sequence ID" value="XM_627179.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3374341"/>
    <dbReference type="KEGG" id="cpv:cgd8_2790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2790"/>
    <dbReference type="InParanoid" id="Q5CVU0"/>
    <dbReference type="OMA" id="HICETIL"/>
    <dbReference type="OrthoDB" id="412233at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="710"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3525"/>
            <end position="3547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4004"/>
            <end position="4041"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4013"/>
            <end position="4028"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="4029"/>
            <end position="4041"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="4180" mass="475460" checksum="A1C30C0816F9CED6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVY8</accession>
    <name>Q5CVY8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein with 5 transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627131.1">
        <property type="nucleotide sequence ID" value="XM_627131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVY8"/>
    <dbReference type="GeneID" id="3374486"/>
    <dbReference type="KEGG" id="cpv:cgd8_2280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2280"/>
    <dbReference type="InParanoid" id="Q5CVY8"/>
    <dbReference type="OMA" id="MICSINK"/>
    <dbReference type="OrthoDB" id="8413490at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="16"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="144"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="177"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="234"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="287" mass="32818" checksum="B287AF868EF63D77" modified="2005-04-12" version="1">MYYQKPKHPFGGFSKYYLATATFLVVALWISSLFSANWQNYVYETKNMGYISFNLSLRGFTIKSRCNRTNYMWSPAMDQYSRNNGSKNFISPISLEEFVCSRFNYFNGKTFGEASAAVCSIDKYQFPNAQNACYNFRMLNIGSLTMIAGIIGCLVCVIFGFITFILSYKNLSIPLTYAYTTLFGCSNLIAMITLPIYYVNAGGSWIAINSFFSLVHFGYPQFTFKSPSVSDIQFFWGYSLAILAFLTSILLPLFGCYFASIASAYNEQLDKESKEYQKFIQKYNNIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVZ3</accession>
    <name>Q5CVZ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_2230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627126.1">
        <property type="nucleotide sequence ID" value="XM_627126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVZ3"/>
    <dbReference type="GeneID" id="3374483"/>
    <dbReference type="KEGG" id="cpv:cgd8_2230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2230"/>
    <dbReference type="InParanoid" id="Q5CVZ3"/>
    <dbReference type="OMA" id="IIMAVID"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF1">
        <property type="entry name" value="HISTIDINE PHOSPHATASE FAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="139" mass="16359" checksum="9D60BE885522FCD7" modified="2005-04-12" version="1">MERASLIITSNLRRAMETSNLISKRSSENCKICVLDFVREKALYISDVPCLSKEEIIKNYPKADISFLPDTNFKDYIVLPEDHEQVDQRIQQFINFIKNYQDLENNEIVLVSHYYFLKRLLKGIFIEILIISTLIKLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW04</accession>
    <name>Q5CW04_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">MIR domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_2110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627115.1">
        <property type="nucleotide sequence ID" value="XM_627115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW04"/>
    <dbReference type="FunCoup" id="Q5CW04">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW04"/>
    <dbReference type="GeneID" id="3374554"/>
    <dbReference type="KEGG" id="cpv:cgd8_2110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2110"/>
    <dbReference type="InParanoid" id="Q5CW04"/>
    <dbReference type="OMA" id="GRKINCD"/>
    <dbReference type="OrthoDB" id="5588846at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd23279">
        <property type="entry name" value="beta-trefoil_MIR_SDF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036300">
        <property type="entry name" value="MIR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016093">
        <property type="entry name" value="MIR_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809:SF2">
        <property type="entry name" value="GH21273P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46809">
        <property type="entry name" value="STROMAL CELL-DERIVED FACTOR 2-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00472">
        <property type="entry name" value="MIR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82109">
        <property type="entry name" value="MIR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254480" description="MIR domain-containing protein" evidence="3">
        <location>
            <begin position="23"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="25"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="84"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="MIR" evidence="4">
        <location>
            <begin position="141"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="225" mass="25413" checksum="B8F4FA1F671B6C1D" modified="2005-04-12" version="1">MFGLFTRFVVVFFGLVFSSVYSEENELVTYGSTVSVLHQNTKCHLYTTKITWANGNQAVTCSKDLDSEGHFYIREADAEYKGAGFPVLCGESIRLLHSVTEKFVQSNKSSKSMISRQIEIFGGSGESSGYFRVECEKKNTGQTIDVKDKIRLYNIEAKGYLTVSKRHIFDNRNCPRCPIVGQYEVTIVSKSSSDNLWSFNSIMMLLHSSRNNQGENSDQESKDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW24</accession>
    <name>Q5CW24_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Epsin like ENTH/VHS domain involved in endocytosis/vesicular trafficking</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_1910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627095.1">
        <property type="nucleotide sequence ID" value="XM_627095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW24"/>
    <dbReference type="STRING" id="353152.Q5CW24"/>
    <dbReference type="GeneID" id="3374468"/>
    <dbReference type="KEGG" id="cpv:cgd8_1910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1910"/>
    <dbReference type="InParanoid" id="Q5CW24"/>
    <dbReference type="OrthoDB" id="4033880at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030125">
        <property type="term" value="C:clathrin vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03571">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.90:FF:000006">
        <property type="entry name" value="Clathrin interactor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013809">
        <property type="entry name" value="ENTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276:SF45">
        <property type="entry name" value="CLATHRIN INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12276">
        <property type="entry name" value="EPSIN/ENT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01417">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00273">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50942">
        <property type="entry name" value="ENTH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ENTH" evidence="2">
        <location>
            <begin position="23"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="521" mass="57476" checksum="7AB7422313637FE3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW35</accession>
    <name>Q5CW35_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627084.1">
        <property type="nucleotide sequence ID" value="XM_627084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW35"/>
    <dbReference type="GeneID" id="3374502"/>
    <dbReference type="KEGG" id="cpv:cgd8_1780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1780"/>
    <dbReference type="InParanoid" id="Q5CW35"/>
    <dbReference type="OMA" id="CIVITRT"/>
    <dbReference type="OrthoDB" id="340046at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254568" evidence="1">
        <location>
            <begin position="21"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="701" mass="79035" checksum="9B949531B5387B7F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW44</accession>
    <name>Q5CW44_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">13 kDa deflagellation-inducible protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627075.1">
        <property type="nucleotide sequence ID" value="XM_627075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW44"/>
    <dbReference type="STRING" id="353152.Q5CW44"/>
    <dbReference type="GeneID" id="3374602"/>
    <dbReference type="KEGG" id="cpv:cgd8_1690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1690"/>
    <dbReference type="InParanoid" id="Q5CW44"/>
    <dbReference type="OMA" id="ETKNEYD"/>
    <dbReference type="OrthoDB" id="295355at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036064">
        <property type="term" value="C:ciliary basal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033362">
        <property type="entry name" value="SSNA1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28661:SF1">
        <property type="entry name" value="MICROTUBULE NUCLEATION FACTOR SSNA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28661">
        <property type="entry name" value="SJOEGREN SYNDROME NUCLEAR AUTOANTIGEN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="7"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12772" checksum="EF193A362AF01F87" modified="2005-04-12" version="1">MADPSAMLNYNAELMKCLEELKEKRDEVNRQIKREEEDKAKIQRELGILNERLKRVSESLQRKTIARAEYDKTIQEIEGAYTKILESSQTLLHVLKRESVNLSNPKKRA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW85</accession>
    <name>Q5CW85_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Clathrin heavy chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_1270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <location evidence="1">Coated pit</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the clathrin heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627034.1">
        <property type="nucleotide sequence ID" value="XM_627034.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CW85">
        <property type="interactions" value="374"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW85"/>
    <dbReference type="GeneID" id="3374266"/>
    <dbReference type="KEGG" id="cpv:cgd8_1270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1270"/>
    <dbReference type="InParanoid" id="Q5CW85"/>
    <dbReference type="OMA" id="HCYDLLH"/>
    <dbReference type="OrthoDB" id="421917at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030132">
        <property type="term" value="C:clathrin coat of coated pit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030130">
        <property type="term" value="C:clathrin coat of trans-Golgi network vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071439">
        <property type="term" value="C:clathrin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032051">
        <property type="term" value="F:clathrin light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006898">
        <property type="term" value="P:receptor-mediated endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.110">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055358">
        <property type="entry name" value="CHCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000547">
        <property type="entry name" value="Clathrin_H-chain/VPS_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016025">
        <property type="entry name" value="Clathrin_H-chain_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016341">
        <property type="entry name" value="Clathrin_heavy_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292:SF1">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10292">
        <property type="entry name" value="CLATHRIN HEAVY CHAIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00637">
        <property type="entry name" value="Clathrin"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13838">
        <property type="entry name" value="Clathrin_H_link"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002290">
        <property type="entry name" value="Clathrin_H_chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00299">
        <property type="entry name" value="CLH"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50989">
        <property type="entry name" value="Clathrin heavy-chain terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50236">
        <property type="entry name" value="CHCR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0168">Coated pit</keyword>
    <keyword evidence="1" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="CHCR" evidence="2">
        <location>
            <begin position="611"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="2">
        <location>
            <begin position="1013"/>
            <end position="1154"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="2">
        <location>
            <begin position="1171"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="2">
        <location>
            <begin position="1356"/>
            <end position="1502"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="2">
        <location>
            <begin position="1507"/>
            <end position="1654"/>
        </location>
    </feature>
    <feature type="repeat" description="CHCR" evidence="2">
        <location>
            <begin position="1729"/>
            <end position="1876"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1667"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1721"/>
            <end position="1749"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1967"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1672"/>
            <end position="1700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1721"/>
            <end position="1730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1976"/>
            <end position="1995"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR002290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2007" mass="225196" checksum="73C7393AC5496A7A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWA2</accession>
    <name>Q5CWA2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NRAP like nucleolar RNA associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_1100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627017.1">
        <property type="nucleotide sequence ID" value="XM_627017.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CWA2">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWA2"/>
    <dbReference type="GeneID" id="3374564"/>
    <dbReference type="KEGG" id="cpv:cgd8_1100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1100"/>
    <dbReference type="InParanoid" id="Q5CWA2"/>
    <dbReference type="OMA" id="WEPQIAG"/>
    <dbReference type="OrthoDB" id="10251401at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006409">
        <property type="term" value="P:tRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005554">
        <property type="entry name" value="NOL6/Upt22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035368">
        <property type="entry name" value="Nrap_D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035369">
        <property type="entry name" value="Nrap_D4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035370">
        <property type="entry name" value="Nrap_D5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17972">
        <property type="entry name" value="NUCLEOLAR RNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17404">
        <property type="entry name" value="Nrap_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17405">
        <property type="entry name" value="Nrap_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17406">
        <property type="entry name" value="Nrap_D5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nrap protein" evidence="1">
        <location>
            <begin position="620"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="2">
        <location>
            <begin position="775"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="domain" description="Nrap protein" evidence="3">
        <location>
            <begin position="989"/>
            <end position="1122"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF17406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1301" mass="151543" checksum="DB93067C1AD757B5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWG3</accession>
    <name>Q5CWG3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine-rich protein with zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_5220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627841.1">
        <property type="nucleotide sequence ID" value="XM_627841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWG3"/>
    <dbReference type="STRING" id="353152.Q5CWG3"/>
    <dbReference type="GeneID" id="3375836"/>
    <dbReference type="KEGG" id="cpv:cgd6_5220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5220"/>
    <dbReference type="InParanoid" id="Q5CWG3"/>
    <dbReference type="OMA" id="ETHENCS"/>
    <dbReference type="OrthoDB" id="340834at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053019">
        <property type="entry name" value="GATA_zinc_finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025258">
        <property type="entry name" value="RH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353:SF36">
        <property type="entry name" value="LIM ZINC-BINDING DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23353">
        <property type="entry name" value="RAB-GAP/TBC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13901">
        <property type="entry name" value="RH_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rubicon Homology" evidence="2">
        <location>
            <begin position="453"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="325"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="642" mass="76829" checksum="876DD1FA40C61841" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWH9</accession>
    <name>Q5CWH9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_5010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90078.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627825.1">
        <property type="nucleotide sequence ID" value="XM_627825.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWH9"/>
    <dbReference type="GeneID" id="3375823"/>
    <dbReference type="KEGG" id="cpv:cgd6_5010"/>
    <dbReference type="InParanoid" id="Q5CWH9"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90078.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="176" mass="19901" checksum="C0F5E60E97BE1BDD" modified="2005-04-12" version="1">MHAISGPNACTLKSELNSRLHAMQILKFEHPADCIYMNGVDNRHFGVGLYCLEDAESQHRIGGINIYDIQSVLEIHDGHPNYSSKTAENVEHKPKMYINAESGVVNFEWDPKDVNLNNPDFTHITCLCSDKSLKLFRIDSDFCSYKLLNSVRSENIDNNNHIIGLDLSCIYSNGTR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWM4</accession>
    <name>Q5CWM4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RRM domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_4490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627780.1">
        <property type="nucleotide sequence ID" value="XM_627780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWM4"/>
    <dbReference type="STRING" id="353152.Q5CWM4"/>
    <dbReference type="GeneID" id="3375913"/>
    <dbReference type="KEGG" id="cpv:cgd6_4490"/>
    <dbReference type="InParanoid" id="Q5CWM4"/>
    <dbReference type="OMA" id="IVWELMI"/>
    <dbReference type="OrthoDB" id="10259687at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097525">
        <property type="term" value="C:spliceosomal snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048026">
        <property type="term" value="P:positive regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12334">
        <property type="entry name" value="RRM1_SF3B4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000895">
        <property type="entry name" value="Hsh49p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000505">
        <property type="entry name" value="Splicing factor 3B subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034158">
        <property type="entry name" value="SF3B4_RRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052084">
        <property type="entry name" value="SF3B4_spliceosome_assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48030:SF3">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="23"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="110"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="216" mass="24545" checksum="107D43BE4A14808C" modified="2005-04-12" version="1" fragment="single">LKKMSISNRIPEIQPIYERNQEATLYCGNLENKVDEEMLAELFSQCGPVKSVHIPRDKVTGHHSGFGFIEFEFVSDVEYAQKVMNSIKLFTKQIRCCKASNDRKPLDIGANLYVGNLSPEIDEKFLFYLFSNFGKILSLKIVGNDQSSQSPKNSAFINFSSFQESDSAIQALNGQFFCNQQISVSYAFKQNSKNEKHGNYAERLLESKSKTKPIQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWQ6</accession>
    <name>Q5CWQ6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinetochore protein NDC80</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd6_4140</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
            <location evidence="10">Centromere</location>
            <location evidence="10">Kinetochore</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the NDC80/HEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627748.1">
        <property type="nucleotide sequence ID" value="XM_627748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWQ6"/>
    <dbReference type="STRING" id="353152.Q5CWQ6"/>
    <dbReference type="GeneID" id="3375762"/>
    <dbReference type="KEGG" id="cpv:cgd6_4140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4140"/>
    <dbReference type="InParanoid" id="Q5CWQ6"/>
    <dbReference type="OMA" id="PSHKFQK"/>
    <dbReference type="OrthoDB" id="7459479at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051315">
        <property type="term" value="P:attachment of mitotic spindle microtubules to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.30">
        <property type="entry name" value="Ncd80 complex, Ncd80 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005550">
        <property type="entry name" value="Kinetochore_Ndc80"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055260">
        <property type="entry name" value="Ndc80_CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038273">
        <property type="entry name" value="Ndc80_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10643:SF2">
        <property type="entry name" value="KINETOCHORE PROTEIN NDC80 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03801">
        <property type="entry name" value="Ndc80_HEC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 10" id="KW-0132">Cell division</keyword>
    <keyword evidence="9 10" id="KW-0137">Centromere</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 10" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="4 10" id="KW-0498">Mitosis</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Ndc80 CH" evidence="13">
        <location>
            <begin position="95"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="76"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="311"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="373"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="552"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU368072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK90017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="696" mass="79608" checksum="4E0E0BF993BBF34D" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWS5</accession>
    <name>Q5CWS5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_3920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627729.1">
        <property type="nucleotide sequence ID" value="XM_627729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWS5"/>
    <dbReference type="SMR" id="Q5CWS5"/>
    <dbReference type="GeneID" id="3375745"/>
    <dbReference type="KEGG" id="cpv:cgd6_3920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3920"/>
    <dbReference type="InParanoid" id="Q5CWS5"/>
    <dbReference type="OMA" id="NWDYNND"/>
    <dbReference type="OrthoDB" id="344056at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253928" evidence="2">
        <location>
            <begin position="24"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="164"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="125"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="271"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="304"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="363"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="385"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="415"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="441"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="468"/>
            <end position="482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="789" mass="91028" checksum="BD7BDDBF75E6C8BE" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWU7</accession>
    <name>Q5CWU7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627707.1">
        <property type="nucleotide sequence ID" value="XM_627707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWU7"/>
    <dbReference type="GeneID" id="3375727"/>
    <dbReference type="KEGG" id="cpv:cgd6_3660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3660"/>
    <dbReference type="InParanoid" id="Q5CWU7"/>
    <dbReference type="OMA" id="EKNKSFC"/>
    <dbReference type="OrthoDB" id="341575at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="17"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="332"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="17"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="365"/>
            <end position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="407" mass="47163" checksum="DA00122BAFFC086B" modified="2007-04-03" version="1">MVRSEFVVNWNSILNEESSNERSNSGSSNTSEDELDRNESKHSSDNENNEEKKLVGNSDKNNEVKEEVKPVIKREITIVNVTLLEVFSKLSLRAKRNLFDFVEDKYLLELRLVCKMLNRYCDGYIRYSLKNCYFFNVPLTRMTMDFWFAAIRFFFLEAGRNLPLNRFKYSPIVAALKHNHKLLPVSVDQMKSHVVVTLDKLLAEHIVFCDHQHPQPHTCDTRLEIKGQSKVFFDEIDIVRFVRQYFMHLEVMDDELIRGSRQLTRYRLAMYFYEFLKSIKMLTEKGNGVFKLSRIEYLVNTGTILRHRIWHQLYASWGSSINVKKSIDANSGKEDKDLGNKSSEQHDSSLSGGKPKRLSDGSARITKTTNKNKSSTSNSKSGIGSNNPDDLVIEVFLTIADHFQWDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWZ6</accession>
    <name>Q5CWZ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_3120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627658.1">
        <property type="nucleotide sequence ID" value="XM_627658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWZ6"/>
    <dbReference type="GeneID" id="3375687"/>
    <dbReference type="KEGG" id="cpv:cgd6_3120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3120"/>
    <dbReference type="InParanoid" id="Q5CWZ6"/>
    <dbReference type="OMA" id="ELWNLPT"/>
    <dbReference type="OrthoDB" id="341414at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="469"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="764"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="469"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="528"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="794" mass="92849" checksum="37E6DF58F62A5358" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX56</accession>
    <name>Q5CX56_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nascent polypeptide-associated complex subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_2430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Part of the nascent polypeptide-associated complex (NAC).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NAC-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627598.1">
        <property type="nucleotide sequence ID" value="XM_627598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX56"/>
    <dbReference type="FunCoup" id="Q5CX56">
        <property type="interactions" value="508"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX56"/>
    <dbReference type="GeneID" id="3376128"/>
    <dbReference type="KEGG" id="cpv:cgd6_2430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2430"/>
    <dbReference type="InParanoid" id="Q5CX56"/>
    <dbReference type="OMA" id="AGDTYME"/>
    <dbReference type="OrthoDB" id="8033832at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd22055">
        <property type="entry name" value="NAC_BTF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.70.30:FF:000001">
        <property type="entry name" value="Transcription factor BTF3 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039370">
        <property type="entry name" value="BTF3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10351">
        <property type="entry name" value="TRANSCRIPTION FACTOR BTF3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NAC-A/B" evidence="3">
        <location>
            <begin position="70"/>
            <end position="135"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="186" mass="21241" checksum="805A07041AFB87A1" modified="2007-04-03" version="1">MEVVARKKFWRSLEFIRTDKYLYKMKPDIKVDDTIEQARQKLRDRFGVGTTQVGGKGTARRKKRAQKPTGVDVKKLQAVTSRFRCQTFPAIGEVTMMKKDGTCLHFSNPKLQASVATNTYILTGNPQEKLIKDLPQQINPMDLSAFLNDPKFQKLLEESQANKLKMASGEDDDIPDLVENFEDVEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY54</accession>
    <name>Q5CY54_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">TRF4/5 nucletotidyl transferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_3630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628526.1">
        <property type="nucleotide sequence ID" value="XM_628524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY54"/>
    <dbReference type="STRING" id="353152.Q5CY54"/>
    <dbReference type="GeneID" id="3372113"/>
    <dbReference type="KEGG" id="cpv:cgd7_3630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3630"/>
    <dbReference type="InParanoid" id="Q5CY54"/>
    <dbReference type="OMA" id="REKCKEW"/>
    <dbReference type="OrthoDB" id="273917at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002058">
        <property type="entry name" value="PAP_assoc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03828">
        <property type="entry name" value="PAP_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="4">
        <location>
            <begin position="130"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="domain" description="PAP-associated" evidence="3">
        <location>
            <begin position="320"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03828"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="480" mass="55121" checksum="8497F01447643B80" modified="2005-04-12" version="1">MFDTLKIKLDGPDAYLLEEEEKVKRSVVLNNMLRSAIQSRNKPDTSKMVETSEFINISSLKRKRNTSNEQFLRSKLNSNGERLESRKYNFFGAGNENDAQGLDKIMKLPWEKIPRYLYKSSGVDLFFIHLNNEIVQLVKWLELTNSEHMLRTRALARITLISHSLWPGSKVQPFGSYYTGLSLPTGDLDVCILNVPGDPKRRLREFASILKEWRLCTGIELILTAKVPIIKYVDSEACISVDISLNQESSIDTTKHISECLKKFSTLRPLLIVIKLFLRQRGLDETYLGGLGSYSQFCLVLSFLQQHSSSYSHTLYKSTTLGHLLFDFLELFGIVFNYSSTGIRLKGKGEYFNRRTTKSDSTLFLESPLPPHNDLGRGAFKYNDVRESFRLAFLDLVESRGRFNKICSSLEETKFKSPEYYSIISSIICTDYELFQCRARTVDKTQLSISAYRKPPYISNEIIKKVKLEMEKLDINVNAT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY64</accession>
    <name>Q5CY64_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PP2C-like phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628516.1">
        <property type="nucleotide sequence ID" value="XM_628514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY64"/>
    <dbReference type="FunCoup" id="Q5CY64">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY64"/>
    <dbReference type="GeneID" id="3372105"/>
    <dbReference type="KEGG" id="cpv:cgd7_3530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3530"/>
    <dbReference type="InParanoid" id="Q5CY64"/>
    <dbReference type="OMA" id="NEDRHIA"/>
    <dbReference type="OrthoDB" id="432045at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF790">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C 22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="148"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="494" mass="56980" checksum="D46E5C20F2A392E6" modified="2005-04-12" version="1">MDYLNLKPYELFREITKDLLRGENVKFYLESKISQEILCDKNQFMEFVNQYYINKKRAQRINKRCDSFKIPLLIDLNGEVVKIGWSLDWDKNLINFNSESAFFLNNKYKFIYLYVVYDHFKDENIKMKLTAGRKLQTEKRDPQSINLNCGYYETKGTKSYMEDRTFLSLDVLNEESTQIKKPIVSFFGIYDGHNGEFTVDYLKSHLHKNFSLAFNQLKYDETIQNTINALVDSFYLTENQIKKHYFNSNSEQIMKEFEIMDHKQGLNINLESSFKGQSIKYISSGSTAIVCCITSSTICVANLGDSRAILCKCGRAYSLTKDHRIKSNLEERERVKNEGGTFDDEGYLSGNLAVSRAFGNWDMYSGMKLQGLSSTPEIYVHNITREDEFLLIACDGIFESFMDQEAISLIRRALVENNDPNLAAEKLVSAALQRQALDNLSAIVVVLTPPNYMAIGNHNFCIDSSAESKKKTNYAHTSNRKIYNFSKLKNLLLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYB4</accession>
    <name>Q5CYB4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Kinase</fullName>
            <ecNumber evidence="8">2.7.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_2990</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:12717"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57660"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.140"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,4,5-trisphosphate + 2 ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + 2 ADP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:32359"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57733"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.151"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the inositol phosphokinase (IPK) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.-.-" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628466.1">
        <property type="nucleotide sequence ID" value="XM_628464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYB4"/>
    <dbReference type="GeneID" id="3372285"/>
    <dbReference type="KEGG" id="cpv:cgd7_2990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2990"/>
    <dbReference type="InParanoid" id="Q5CYB4"/>
    <dbReference type="OMA" id="WIDFTHI"/>
    <dbReference type="OrthoDB" id="2573163at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047326">
        <property type="term" value="F:inositol-1,3,4,6-tetrakisphosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008440">
        <property type="term" value="F:inositol-1,4,5-trisphosphate 3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.160">
        <property type="entry name" value="Inositol polyphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005522">
        <property type="entry name" value="IPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038286">
        <property type="entry name" value="IPK_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12400:SF51">
        <property type="entry name" value="INOSITOL POLYPHOSPHATE MULTIKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03770">
        <property type="entry name" value="IPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00036164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00036525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="288" mass="34141" checksum="CDD50056C6CFE460" modified="2005-04-12" version="1">MFCSSINSFELFPFQVLSTEKNERFMGSTLLLTTKDNKYIYKILKNDNCNELDFYSSINKQHLLKRHDIIPKFIRFVLIIEVGKKSKKIYLRKSFINSILNKKMHNLQHFKIESAIEMKNFLSGYSNINIIDLKLGTSWIGESKNDSIYNLREVFTKTFPDEDLVQEFNDIFCKIERIPEKTEFMNGMLYKLKSLRKSIKQYMIINNSCQYEIGIRIQGLISDKITISRQRGKELTSNETMKLLSEFLKLSPNLIRLTRKKVELLKFWLERQKSYRFIATSIVLAFDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYE6</accession>
    <name>Q5CYE6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Patatin like esterase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_2630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628434.1">
        <property type="nucleotide sequence ID" value="XM_628432.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYE6"/>
    <dbReference type="STRING" id="353152.Q5CYE6"/>
    <dbReference type="GeneID" id="3371929"/>
    <dbReference type="KEGG" id="cpv:cgd7_2630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2630"/>
    <dbReference type="InParanoid" id="Q5CYE6"/>
    <dbReference type="OMA" id="FENISYM"/>
    <dbReference type="OrthoDB" id="197155at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019433">
        <property type="term" value="P:triglyceride catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07224">
        <property type="entry name" value="Pat_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033562">
        <property type="entry name" value="PLPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406">
        <property type="entry name" value="CALCIUM-INDEPENDENT PHOSPHOLIPASE A2 IPLA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12406:SF7">
        <property type="entry name" value="PATATIN-LIKE PHOSPHOLIPASE DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="144"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="177"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="484" mass="54231" checksum="2A13EABA39374F43" modified="2005-04-12" version="1">MISEREKLSRIDGKDLLCNESAKVPVSSANSDKQKSWSMKFGIYSKKTISDAQSNYLNQDLDSAMESNNKPRNCNTSSDLNTPNNNGNYSFWPNSFEDIQKGGSAVFNRLASRIEEGIQDLQSQIRPDFPKLPDSLEGKIPLGFSFSVSAMLIPYHLGVILELQEQGYITESTPLSGASGGSIAAICCALDISMYEAMEACISLYEDCRKNGTAGRLNEVLERELRKKLPDNVIELLNNRSEKGGQIIISFTQLLPVPKAHFVSDFNSKDDLIECILASSTIPFLSVPWPTFKCRGKPCVDGYFAVGRGELGCLPTNAIRTVKVCPLPSAGSSMKSNRSDVISPHIQSYDWILFSPDSNNNNEDFTRTRKWIRSLRPAGVNLKDFEQSLVDSMNTKESKINGIKEESFELRETFNSCYINNNPNFNAPPLMKYSNNELLRIAVDPPSSQVAWELFYIGRGDALRWIMMDRIRESSYKLMEPTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYE8</accession>
    <name>Q5CYE8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">POZ+kelch domain protein with kelch repeats at the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_2610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628432.1">
        <property type="nucleotide sequence ID" value="XM_628430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYE8"/>
    <dbReference type="SMR" id="Q5CYE8"/>
    <dbReference type="STRING" id="353152.Q5CYE8"/>
    <dbReference type="GeneID" id="3371927"/>
    <dbReference type="KEGG" id="cpv:cgd7_2610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2610"/>
    <dbReference type="InParanoid" id="Q5CYE8"/>
    <dbReference type="OMA" id="YFQEYKN"/>
    <dbReference type="OrthoDB" id="191037at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051260">
        <property type="term" value="P:protein homooligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18316">
        <property type="entry name" value="BTB_POZ_KCTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006652">
        <property type="entry name" value="Kelch_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003131">
        <property type="entry name" value="T1-type_BTB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412">
        <property type="entry name" value="KELCH PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24412:SF489">
        <property type="entry name" value="RING FINGER DOMAIN AND KELCH REPEAT-CONTAINING PROTEIN DDB_G0271372"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02214">
        <property type="entry name" value="BTB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01344">
        <property type="entry name" value="Kelch_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00612">
        <property type="entry name" value="Kelch"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="4">
        <location>
            <begin position="172"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="580" mass="66164" checksum="62175D634605A981" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYF9</accession>
    <name>Q5CYF9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628421.1">
        <property type="nucleotide sequence ID" value="XM_628419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYF9"/>
    <dbReference type="GeneID" id="3371917"/>
    <dbReference type="KEGG" id="cpv:cgd7_2480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2480"/>
    <dbReference type="InParanoid" id="Q5CYF9"/>
    <dbReference type="OMA" id="SSALMMW"/>
    <dbReference type="OrthoDB" id="2190219at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="240" mass="26878" checksum="F9E20A13D4CC49CF" modified="2005-04-12" version="1">MQQNKQTVGGIGHFHSSLKDVEAQSQISCAAYKQQWIAKVARVPPRKVHTTNISRIKNRLFAFNQRSCALSIGTMVGNFKYICSWAKLLGLTISSFLFIWVLYCFSIIKYLKGDQHIEYFYTNVLCLVISLISFTMLSTSLIIPNSTAINLNSMESSLLAGSGVATRNLISCKTLSTLYLVISLLSIFTALLPQMESYHFTITMLSMILATHLAPSVLFYIAYLRGEDGCIDDRSHHTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYG2</accession>
    <name>Q5CYG2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible membrane associated transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628418.1">
        <property type="nucleotide sequence ID" value="XM_628416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYG2"/>
    <dbReference type="STRING" id="353152.Q5CYG2"/>
    <dbReference type="GeneID" id="3372215"/>
    <dbReference type="KEGG" id="cpv:cgd7_2450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2450"/>
    <dbReference type="InParanoid" id="Q5CYG2"/>
    <dbReference type="OMA" id="ALCCFGR"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="58"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="293"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="385"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="454" mass="52193" checksum="59FE4B4486BD6B8A" modified="2005-04-12" version="1">MNFRLLIRDLLNKDKTFWSPLIGCALIHWSLGFANTFGNTVPYIASYISLKGKHKLRAGMICWIECFFVLFQGGANYLYPSIELIIGIPSCLAIGFFFCNFGLLISYLFLENYFLYLFGYSILYAIGNGLLFASTIEFLASNYSKNSRSKIIGVLWLFRGASMSIIPSFQSSFVNPINSNNYYVYSGNKFFNSLIVLEKVPKLLKLTFIFSAIFQITGIANLAITGRKYPRIKEKQEQYISDKRCHFANRIYTSEPFVLLWLITFLSWPCIEYIQLFWKVHGMTNTGLGDLQLTRVSCIIMILQTLFRVFWGIFGQLAGYFNCICILSIILVTGIILLMFPIIESISIFQYILGYLLVSIAHSGNLTIFPTTIVKHYCQSNQMELFIYLFSAKAASCIFFCILTDFTTRFLNINYSLVPLLIFSLGSFFLSFILRDIKDNYILEKNSKKRYINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYH8</accession>
    <name>Q5CYH8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">60S ribosomal protein L40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_2280</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the 60S subunit of the ribosome.</text>
    </comment>
    <comment type="subunit">
        <text evidence="11">Part of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628402.1">
        <property type="nucleotide sequence ID" value="XM_628400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYH8"/>
    <dbReference type="FunCoup" id="Q5CYH8">
        <property type="interactions" value="452"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYH8"/>
    <dbReference type="GeneID" id="3371966"/>
    <dbReference type="KEGG" id="cpv:cgd7_2280"/>
    <dbReference type="InParanoid" id="Q5CYH8"/>
    <dbReference type="OMA" id="CGRCSQL"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000014">
        <property type="entry name" value="Ubiquitin-60S ribosomal L40 fusion"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.1060.50:FF:000001">
        <property type="entry name" value="ubiquitin-60S ribosomal protein L40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001975">
        <property type="entry name" value="Ribosomal_eL40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038587">
        <property type="entry name" value="Ribosomal_eL40_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01020">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01377">
        <property type="entry name" value="Ribosomal_L40e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="12">
        <location>
            <begin position="5"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010570"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00035124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK90618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="132" mass="15110" checksum="4E24CC84CA6E6D6C" modified="2005-04-12" version="1" fragment="single">DAKKMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGVIEPSLANLARQYNCEKMICRKCYARLPPRATNCRKRKCGRTSQIRPKKKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYJ7</accession>
    <name>Q5CYJ7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Vacuolar protein sorting-associated protein 29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_2060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="journal article" date="2007" name="Mol. Biochem. Parasitol." volume="151" first="100" last="110">
            <title>Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.</title>
            <authorList>
                <person name="Vedadi M."/>
                <person name="Lew J."/>
                <person name="Artz J."/>
                <person name="Amani M."/>
                <person name="Zhao Y."/>
                <person name="Dong A."/>
                <person name="Wasney G.A."/>
                <person name="Gao M."/>
                <person name="Hills T."/>
                <person name="Brokx S."/>
                <person name="Qiu W."/>
                <person name="Sharma S."/>
                <person name="Diassiti A."/>
                <person name="Alam Z."/>
                <person name="Melone M."/>
                <person name="Mulichak A."/>
                <person name="Wernimont A."/>
                <person name="Bray J."/>
                <person name="Loppnau P."/>
                <person name="Plotnikova O."/>
                <person name="Newberry K."/>
                <person name="Sundararajan E."/>
                <person name="Houston S."/>
                <person name="Walker J."/>
                <person name="Tempel W."/>
                <person name="Bochkarev A."/>
                <person name="Kozieradzki I."/>
                <person name="Edwards A."/>
                <person name="Arrowsmith C."/>
                <person name="Roos D."/>
                <person name="Kain K."/>
                <person name="Hui R."/>
            </authorList>
            <dbReference type="PubMed" id="17125854"/>
            <dbReference type="DOI" id="10.1016/j.molbiopara.2006.10.011"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 2-197</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the VPS29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628383.1">
        <property type="nucleotide sequence ID" value="XM_628381.1"/>
    </dbReference>
    <dbReference type="PDB" id="2A22">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A/B=2-197"/>
    </dbReference>
    <dbReference type="PDBsum" id="2A22"/>
    <dbReference type="AlphaFoldDB" id="Q5CYJ7"/>
    <dbReference type="SMR" id="Q5CYJ7"/>
    <dbReference type="FunCoup" id="Q5CYJ7">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYJ7"/>
    <dbReference type="GeneID" id="3371886"/>
    <dbReference type="KEGG" id="cpv:cgd7_2060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2060"/>
    <dbReference type="InParanoid" id="Q5CYJ7"/>
    <dbReference type="OMA" id="VRGNMDY"/>
    <dbReference type="OrthoDB" id="10258130at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CYJ7"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031410">
        <property type="term" value="C:cytoplasmic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07394">
        <property type="entry name" value="MPP_Vps29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000015">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024654">
        <property type="entry name" value="Calcineurin-like_PHP_lpxH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000979">
        <property type="entry name" value="Phosphodiesterase_MJ0936/Vps29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028661">
        <property type="entry name" value="Vps29"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00040">
        <property type="entry name" value="yfcE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11124">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN VPS29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12850">
        <property type="entry name" value="Metallophos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="23"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU362040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="2A22"/>
        </source>
    </evidence>
    <sequence length="197" mass="21855" checksum="B7CF2465B4FB703B" modified="2005-04-12" version="1">MSSTDFGDLVLLIGDLKIPYGAKELPSNFRELLATDKINYVLCTGNVCSQEYVEMLKNITKNVYIVSGDLDSAIFNPDPESNGVFPEYVVVQIGEFKIGLMHGNQVLPWDDPGSLEQWQRRLDCDILVTGHTHKLRVFEKNGKLFLNPGTATGAFSALTPDAPPSFMLMALQGNKVVLYVYDLRDGKTNVAMSEFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYK9</accession>
    <name>Q5CYK9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_1940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628371.1">
        <property type="nucleotide sequence ID" value="XM_628369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYK9"/>
    <dbReference type="GeneID" id="3371879"/>
    <dbReference type="KEGG" id="cpv:cgd7_1940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1940"/>
    <dbReference type="InParanoid" id="Q5CYK9"/>
    <dbReference type="OMA" id="TIMGNIC"/>
    <dbReference type="OrthoDB" id="10255522at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="361"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="564" mass="62896" checksum="FC494582E66C550E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYT3</accession>
    <name>Q5CYT3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Shares a domain with the CWFL/SRm300 family RNA binding proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_1110</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628297.1">
        <property type="nucleotide sequence ID" value="XM_628295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYT3"/>
    <dbReference type="STRING" id="353152.Q5CYT3"/>
    <dbReference type="GeneID" id="3371844"/>
    <dbReference type="KEGG" id="cpv:cgd7_1110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1110"/>
    <dbReference type="InParanoid" id="Q5CYT3"/>
    <dbReference type="OMA" id="GRSHYDG"/>
    <dbReference type="OrthoDB" id="10267305at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051372">
        <property type="entry name" value="CWC21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013170">
        <property type="entry name" value="mRNA_splic_Cwf21_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562">
        <property type="entry name" value="SERINE/ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36562:SF5">
        <property type="entry name" value="SERINE_ARGININE REPETITIVE MATRIX 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01115">
        <property type="entry name" value="cwf21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="CWF21" evidence="8">
        <location>
            <begin position="59"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="174"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="264"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="179"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="267"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="286"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="372"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="409" mass="47535" checksum="5AB4DDE2FE003563" modified="2005-04-12" version="1">MYNGVGLRTARGSGTSGHVQKNLSAYIPKQWERKNNKDGINSKSGPRIPRTTRHDPELIEHEKLRKMELEILQFTEEQESKGLKGADLEEAVDRKREELALLLKKNSNSIRNYKDCNGSFDSRKEIGFVSSQFGDNVDKLDSNQLSRLKEEELKVFRSALGLDKPTRGRYKQRYNNKRSRNEITFRNKMTNEDWENEQERERNERREGVSSKKGDIFTQEVNNEDGLGQRNFENLREDFGNYNKDNQDNIDEFEGVNKAQIRRKLGLQSQMNSKSYFESSPKPRSHSYSYSCSRSHSNSSPHSYSNSRSYSNSPSSSQSKSNSYSRSRSNSYSKSRNSYFNNYKQKSSKKKVKREAYSSSVRNLAELDSLERKKKHRYRKPRRSRSPSTVSRYRSFSRSLSPQHLALAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYU5</accession>
    <name>Q5CYU5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Syf1p. protein with 8 HAT domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd7_970</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628285.1">
        <property type="nucleotide sequence ID" value="XM_628283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYU5"/>
    <dbReference type="STRING" id="353152.Q5CYU5"/>
    <dbReference type="GeneID" id="3371994"/>
    <dbReference type="KEGG" id="cpv:cgd7_970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_970"/>
    <dbReference type="InParanoid" id="Q5CYU5"/>
    <dbReference type="OMA" id="IWYNYLR"/>
    <dbReference type="OrthoDB" id="10067343at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000349">
        <property type="term" value="P:generation of catalytic spliceosome for first transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055433">
        <property type="entry name" value="HAT_Syf1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056350">
        <property type="entry name" value="HAT_Syf1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055430">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23231">
        <property type="entry name" value="HAT_Syf1_CNRKL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23233">
        <property type="entry name" value="HAT_Syf1_CNRKL1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23220">
        <property type="entry name" value="HAT_Syf1_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1-like N-terminal HAT-repeats" evidence="11">
        <location>
            <begin position="108"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor SYF1 central HAT repeats" evidence="9">
        <location>
            <begin position="363"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-splicing factor Syf1/CRNKL1-like C-terminal HAT-repeats" evidence="10">
        <location>
            <begin position="553"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="922"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="982"/>
            <end position="998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF23233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1020" mass="119816" checksum="1BE2A80126541467" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ03</accession>
    <name>Q5CZ03_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628227.1">
        <property type="nucleotide sequence ID" value="XM_628225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ03"/>
    <dbReference type="GeneID" id="3371903"/>
    <dbReference type="KEGG" id="cpv:cgd7_350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_350"/>
    <dbReference type="InParanoid" id="Q5CZ03"/>
    <dbReference type="OMA" id="HWNTNTD"/>
    <dbReference type="OrthoDB" id="360686at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="374" mass="42568" checksum="2341E6F2503D1639" modified="2005-04-12" version="1">MQNTLDNSNSAHASESASVNKILANVQGYYSGDYDWNDFYGDDDDFSVDEDDDMKLDPNAILTSNSNKFDSIIQDKLKIFQNKGSTDNSNLGDVRFRQRIRNRRMRHKANEDDNPDFLHDEIEQIQRGEEIAALSPEEMNEIRSTAWIPKGEYIPEDIIMGYHTAWDIGKRGCVAVKLVGNWDSHISPNKVRFFIMDGTDPIAFLSYYTKSDLKVSRGEKSEKKGIIFAKDLRDGYWDYGRSKIIFTRRNKSGQTTIIENLPTQFMDAMMVCIREIEVHKKVTKIIKERRKQANNNTLDKNPAKIIVNSGISNSDDPNSNLLDTDISKNNLVPDKNDFIEDAEVVVPLGNALTGKRASITKLVAPKIDFEKLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ13</accession>
    <name>Q5CZ13_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628217.1">
        <property type="nucleotide sequence ID" value="XM_628215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ13"/>
    <dbReference type="GeneID" id="3372039"/>
    <dbReference type="KEGG" id="cpv:cgd7_240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_240"/>
    <dbReference type="InParanoid" id="Q5CZ13"/>
    <dbReference type="OMA" id="ARWAITI"/>
    <dbReference type="OrthoDB" id="341483at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="144"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="216"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="35"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="303" mass="34980" checksum="0C45C3714BDFF1C1" modified="2005-04-12" version="1">MQSSKTITDQFEELIKKAKTLNKTHPVVQEENVDDKNKKNELNSAKLEISMLQKRHEMCVVQKNAIKDLINLHKEELQLLESALRTIESEEKKVLEIILRETLDGDSLTRATSVEMVERDNDSAYTKSILPSEDLSTQTTYENLEHDASKSYTSSNNRDPEYSNDEYSYKDELESDESNDYSDNTSEQEDFSSRYSTSRVNTERKVRFSIDDLGVSSETKSNNVSKSNSSYSVTNAARPSNSIRTTISIPQRYNYIRNRNSSLMKEISIKKILEGNRKLDMEEKDQGQRELVRKLHTLYSSKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ14</accession>
    <name>Q5CZ14_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal RNA-processing protein 43</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd7_230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628216.1">
        <property type="nucleotide sequence ID" value="XM_628214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ14"/>
    <dbReference type="SMR" id="Q5CZ14"/>
    <dbReference type="STRING" id="353152.Q5CZ14"/>
    <dbReference type="GeneID" id="3372038"/>
    <dbReference type="KEGG" id="cpv:cgd7_230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_230"/>
    <dbReference type="InParanoid" id="Q5CZ14"/>
    <dbReference type="OMA" id="EIKAFWV"/>
    <dbReference type="OrthoDB" id="45882at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF9">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="10">
        <location>
            <begin position="33"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00030617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK90518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="291" mass="32962" checksum="9B673C26A768D0E2" modified="2005-04-12" version="1">MNKSSLWYLRPDEYLNRFLEQGVRCDGRKPEVCRNFKLELNELSSSNYGAVSVRIGNSSYIACCSPQIIHTGLDQESNNAITNTRINVSLELPTICGFTGNPNHSNFVSNSITECLNDSRIINKEAFITKFQGKELHWLIDIKVVCLSYDGNPLDYTLIASIASLRNTILPKNLVWDDDYNWFRISSDPISKDEVKREQMMQDSSSFFLKKVPIFVSFSYLNDSIWVCDPNYMEDSIGSSVTICCVDNQINTLQTQCISKYTPGKLKSNLSQLIDVASKRADEIRACLLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPM8</accession>
    <name>A3FPM8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd7_1320</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388374.1">
        <property type="nucleotide sequence ID" value="XM_001388337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPM8"/>
    <dbReference type="STRING" id="353152.A3FPM8"/>
    <dbReference type="GeneID" id="3371780"/>
    <dbReference type="KEGG" id="cpv:cgd7_1320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1320"/>
    <dbReference type="InParanoid" id="A3FPM8"/>
    <dbReference type="OMA" id="MITHLEY"/>
    <dbReference type="OrthoDB" id="340602at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002653037" description="non-specific serine/threonine protein kinase" evidence="9">
        <location>
            <begin position="22"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="74"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="520" mass="60247" checksum="8B10D31CDDC87579" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPT2</accession>
    <name>A3FPT2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_1410</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388311.1">
        <property type="nucleotide sequence ID" value="XM_001388274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPT2"/>
    <dbReference type="FunCoup" id="A3FPT2">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPT2"/>
    <dbReference type="GeneID" id="3375936"/>
    <dbReference type="KEGG" id="cpv:cgd6_1410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1410"/>
    <dbReference type="InParanoid" id="A3FPT2"/>
    <dbReference type="OMA" id="MKEVDQV"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000390">
        <property type="term" value="P:spliceosomal complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000191">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF85">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="360"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="542"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1005" mass="114256" checksum="D2F6B2C9C77E0A8A" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPV4</accession>
    <name>A3FPV4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">2Fe-2S ferredoxin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_3000</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adrenodoxin/putidaredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388333.1">
        <property type="nucleotide sequence ID" value="XM_001388296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPV4"/>
    <dbReference type="FunCoup" id="A3FPV4">
        <property type="interactions" value="127"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPV4"/>
    <dbReference type="GeneID" id="3375958"/>
    <dbReference type="KEGG" id="cpv:cgd6_3000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3000"/>
    <dbReference type="InParanoid" id="A3FPV4"/>
    <dbReference type="OMA" id="TPMEEDM"/>
    <dbReference type="OrthoDB" id="268593at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140647">
        <property type="term" value="P:P450-containing electron transport chain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00207">
        <property type="entry name" value="fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036010">
        <property type="entry name" value="2Fe-2S_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001041">
        <property type="entry name" value="2Fe-2S_ferredoxin-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001055">
        <property type="entry name" value="Adrenodoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018298">
        <property type="entry name" value="Adrenodoxin_Fe-S_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426:SF72">
        <property type="entry name" value="2FE-2S FERREDOXIN-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23426">
        <property type="entry name" value="FERREDOXIN/ADRENODOXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00111">
        <property type="entry name" value="Fer2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00355">
        <property type="entry name" value="ADRENODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54292">
        <property type="entry name" value="2Fe-2S ferredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51085">
        <property type="entry name" value="2FE2S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00814">
        <property type="entry name" value="ADX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="6" id="KW-0249">Electron transport</keyword>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="2Fe-2S ferredoxin-type" evidence="10">
        <location>
            <begin position="52"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00019395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="167" mass="19310" checksum="ED5E6744F8A1A33E" modified="2007-04-03" version="1" fragment="single">MVNNLIWRISRPISSRVFSAIPYFSKRTLFLSFKRFFHSDPELWTKDVHPKIELSFILRDGEKKVFNAPKNISLLEAAQHEELDIEGACEASLACSTCHVILDKEIYDELEPPSEREEDMLDMAPQVCETSRLACQIKVDERLTKGNIHLPNMTRNFYVDGFKPSPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ09</accession>
    <name>A3FQ09_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_5070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388450.1">
        <property type="nucleotide sequence ID" value="XM_001388413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ09"/>
    <dbReference type="FunCoup" id="A3FQ09">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ09"/>
    <dbReference type="GeneID" id="3374364"/>
    <dbReference type="KEGG" id="cpv:cgd8_5070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5070"/>
    <dbReference type="InParanoid" id="A3FQ09"/>
    <dbReference type="OMA" id="RYMNQFI"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14825">
        <property type="entry name" value="TRAPPC2_sedlin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006722">
        <property type="entry name" value="Sedlin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12403">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04628">
        <property type="entry name" value="Sedlin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAZ51490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="142" mass="16191" checksum="030F20E6D49EB46D" modified="2007-04-03" version="1" fragment="single">MIHTNQDCLIFTIVGRNDSPLYEVDLSNNTGKIGSNGCADELLIHASLDALDENTWRNSALYMRTIYKLGDTQISAFVTPGHTKFLLLHHGKSSENIRQFFNEVRDLYVKILMNPFQEANQPILTPSFDVRVRQAARRLLLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ26</accession>
    <name>A3FQ26_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidylserine decarboxylase</fullName>
            <ecNumber evidence="3">4.1.1.65</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd3_2100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyruvate</name>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="11">Phospholipid metabolism; phosphatidylethanolamine biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.65" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388106.1">
        <property type="nucleotide sequence ID" value="XM_001388069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ26"/>
    <dbReference type="FunCoup" id="A3FQ26">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ26"/>
    <dbReference type="GeneID" id="3374081"/>
    <dbReference type="KEGG" id="cpv:cgd3_2100"/>
    <dbReference type="InParanoid" id="A3FQ26"/>
    <dbReference type="OMA" id="KDYHHYH"/>
    <dbReference type="OrthoDB" id="4330at2759"/>
    <dbReference type="UniPathway" id="UPA00558"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004609">
        <property type="term" value="F:phosphatidylserine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003817">
        <property type="entry name" value="PS_Dcarbxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033177">
        <property type="entry name" value="PSD-B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00163">
        <property type="entry name" value="PS_decarb"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10067:SF6">
        <property type="entry name" value="PHOSPHATIDYLSERINE DECARBOXYLASE PROENZYME, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02666">
        <property type="entry name" value="PS_Dcarbxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="10" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012243"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="314" mass="35998" checksum="6D9147ECB8344AFE" modified="2007-04-03" version="1" fragment="single">IFFYRSLFGRTRSRFLGKLLNINLPVSIRRRIYGFLINNYLYKDSSFSAYSKDEKIKKFEEKHANSLDSYRSIGELFTRSIRPSEIVFQCLEDPNSISSPCEGRTIEFGEINSDKCIQVKSSTFKVSELLQENFASLTNSSNLYYMIIYLSPKDYHRFHSPTNIEIKSVRHISGECFPVFKGIASKLNNLFSINERVVIKSEWEHGKMYIVAVAAHGVSDIKLFCVPNLKTNQRGSNLNYLRKGKTGQFIEYSDFKNCKNQGKYLKGDELGLFNLGSTIVLIFQAPENFKFDVDRGIKLKLGQIIGKVLDSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ29</accession>
    <name>A3FQ29_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">cGMP phosphodiesterase A4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_2320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388109.1">
        <property type="nucleotide sequence ID" value="XM_001388072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ29"/>
    <dbReference type="SMR" id="A3FQ29"/>
    <dbReference type="STRING" id="353152.A3FQ29"/>
    <dbReference type="GeneID" id="3374079"/>
    <dbReference type="KEGG" id="cpv:cgd3_2320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2320"/>
    <dbReference type="InParanoid" id="A3FQ29"/>
    <dbReference type="OMA" id="RNTESRM"/>
    <dbReference type="OrthoDB" id="546632at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="153"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="244"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="7">
        <location>
            <begin position="617"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="725"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="725"/>
            <end position="729"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="729"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="765"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="766"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="766"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="766"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="881"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="881"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="932"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="997" mass="112679" checksum="6AEBA31F52F1816C" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ48</accession>
    <name>A3FQ48_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">isoleucine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Isoleucyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd3_3840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>tRNA(Ile) + L-isoleucine + ATP = L-isoleucyl-tRNA(Ile) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:9666"/>
            <dbReference type="Rhea" id="RHEA-COMP:9695"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58045"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78528"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.5"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.5" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388128.1">
        <property type="nucleotide sequence ID" value="XM_001388091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ48"/>
    <dbReference type="FunCoup" id="A3FQ48">
        <property type="interactions" value="413"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ48"/>
    <dbReference type="GeneID" id="3373818"/>
    <dbReference type="KEGG" id="cpv:cgd3_3840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3840"/>
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    <dbReference type="OMA" id="EIIVIHK"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="UniProtKB-EC"/>
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        <property type="term" value="P:isoleucyl-tRNA aminoacylation"/>
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        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
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    <dbReference type="InterPro" id="IPR002301">
        <property type="entry name" value="Ile-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023586">
        <property type="entry name" value="Ile-tRNA-ligase_type2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
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    </dbReference>
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        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
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    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
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    <dbReference type="NCBIfam" id="TIGR00392">
        <property type="entry name" value="ileS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780:SF1">
        <property type="entry name" value="ISOLEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42780">
        <property type="entry name" value="SOLEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="DUF5915"/>
        <property type="match status" value="1"/>
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    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
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    <dbReference type="PRINTS" id="PR00984">
        <property type="entry name" value="TRNASYNTHILE"/>
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    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
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    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
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    </dbReference>
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    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="11">
        <location>
            <begin position="20"/>
            <end position="651"/>
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    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="12">
        <location>
            <begin position="707"/>
            <end position="861"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAZ51456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1100" mass="128761" checksum="FE85D7FB84A3F53E" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ51</accession>
    <name>A3FQ51_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cutinase negative acting protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_4150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388131.1">
        <property type="nucleotide sequence ID" value="XM_001388094.1"/>
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    <dbReference type="AlphaFoldDB" id="A3FQ51"/>
    <dbReference type="STRING" id="353152.A3FQ51"/>
    <dbReference type="GeneID" id="3373815"/>
    <dbReference type="KEGG" id="cpv:cgd3_4150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4150"/>
    <dbReference type="InParanoid" id="A3FQ51"/>
    <dbReference type="OMA" id="KEAPKHR"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="507"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="592"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="668"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="70"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="102"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="125"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="170"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="207"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="298"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="380"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="443"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="456"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="670"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="687"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="711" mass="74634" checksum="20BB8402CB678999" modified="2007-04-03" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQD8</accession>
    <name>A3FQD8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rab2 GTPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_2060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388160.1">
        <property type="nucleotide sequence ID" value="XM_001388123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQD8"/>
    <dbReference type="FunCoup" id="A3FQD8">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQD8"/>
    <dbReference type="GeneID" id="3371410"/>
    <dbReference type="KEGG" id="cpv:cgd1_2060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2060"/>
    <dbReference type="InParanoid" id="A3FQD8"/>
    <dbReference type="OMA" id="TNATHAC"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000263">
        <property type="entry name" value="Ras-related protein RABB1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="185" mass="21088" checksum="6D9E6E8238D91AE4" modified="2007-04-03" version="1">MASPYDYLFKYIIIGDTAVGKSCLLLQFTDRRFRVDHDLTIGVEFGARIINLDAKKIKLQIWDTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLSKWLNDVKRNATPNMTIILVGNKSDLDRREVTTEEGVEFAEKNGLLFIETSAKTSNNVEEAFMKVAEKIYKNILDGIYDLSNEVSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQJ2</accession>
    <name>A3FQJ2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388276.1">
        <property type="nucleotide sequence ID" value="XM_001388239.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQJ2"/>
    <dbReference type="STRING" id="353152.A3FQJ2"/>
    <dbReference type="GeneID" id="3373322"/>
    <dbReference type="KEGG" id="cpv:cgd5_2920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2920"/>
    <dbReference type="InParanoid" id="A3FQJ2"/>
    <dbReference type="OMA" id="TIRYLMH"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="1">
        <location>
            <begin position="186"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="677" mass="78958" checksum="EC11DD236177A9F8" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQJ8</accession>
    <name>A3FQJ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd5_3160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388282.1">
        <property type="nucleotide sequence ID" value="XM_001388245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQJ8"/>
    <dbReference type="SMR" id="A3FQJ8"/>
    <dbReference type="STRING" id="353152.A3FQJ8"/>
    <dbReference type="GeneID" id="3373328"/>
    <dbReference type="KEGG" id="cpv:cgd5_3160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3160"/>
    <dbReference type="InParanoid" id="A3FQJ8"/>
    <dbReference type="OMA" id="FHTTAER"/>
    <dbReference type="OrthoDB" id="422673at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10224">
        <property type="entry name" value="ASKHA_NBD_actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.36.70:FF:000001">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000291">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000001">
        <property type="entry name" value="Actin, muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000404">
        <property type="entry name" value="Major actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000058">
        <property type="entry name" value="Putative actin-related protein 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020902">
        <property type="entry name" value="Actin/actin-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004001">
        <property type="entry name" value="Actin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00406">
        <property type="entry name" value="ACTINS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00432">
        <property type="entry name" value="ACTINS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01132">
        <property type="entry name" value="ACTINS_ACT_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="376" mass="42174" checksum="87FF917ACCF46D0B" modified="2007-04-03" version="1">MSEEETQALVVDNGSGMVKAGVAGDDAPRCVFPSIVGRPKMPGVMVGMDQKDCYVGDEAQSKRGILTLKYPIEHGIVTNWEDMEKIWHHTFYNELRVAPEEHPVLLTEAPMNPKVNRERMTQIMFETFNVPAMYVNIQAVLSLYASGRTTGIVLDSGDGVSHTVPIYEGYAIPHAIMRLDLAGRDLTDFLMKILHDRGYSFTTTAEREIVRDIKEKLCYIALDYEEEMKKSQESSELEKTYELPDGHVITVGSERFRCPEALFQPGFLGKEAVGIGETTFQSIMKCDLDIRKDLYANIVLSGGTTMYPGIGERMTKELTSLAPSTMKIKVVAPPERKYSVWIGGSILSSLSTFQQMWITKEEYDESGPSIVHRKCF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQK1</accession>
    <name>A3FQK1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="3">PPIase</shortName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_3350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388285.1">
        <property type="nucleotide sequence ID" value="XM_001388248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQK1"/>
    <dbReference type="STRING" id="353152.A3FQK1"/>
    <dbReference type="GeneID" id="3373331"/>
    <dbReference type="KEGG" id="cpv:cgd5_3350"/>
    <dbReference type="InParanoid" id="A3FQK1"/>
    <dbReference type="OMA" id="ENFKRTH"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000023">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="34"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="167" mass="18015" checksum="93E0C263935FD64D" modified="2007-04-03" version="1">MESGLKAQGEVSPRSDASPNTLIKLPTKKNTHVFFDISIGGTPTGRVVFELFTEIAPLTSENFRALCTGEKGRSQNGVDLHYKGCKFHRIIPEFMCQGGDISSGNGTGGESIYGPTFDDENFVLKHNSAGLLSMANSGPNTNSSQFFITTIPCPWLDGRHVVFGKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQM1</accession>
    <name>A3FQM1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd4_3330</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388076.1">
        <property type="nucleotide sequence ID" value="XM_001388039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQM1"/>
    <dbReference type="SMR" id="A3FQM1"/>
    <dbReference type="STRING" id="353152.A3FQM1"/>
    <dbReference type="GeneID" id="3372775"/>
    <dbReference type="KEGG" id="cpv:cgd4_3330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3330"/>
    <dbReference type="InParanoid" id="A3FQM1"/>
    <dbReference type="OMA" id="MYWEILC"/>
    <dbReference type="OrthoDB" id="424326at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="111"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="180"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="485"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="554"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="591"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="209"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAZ51264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="622" mass="71517" checksum="D6EA9DE12C109E4F" modified="2007-04-03" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQR0</accession>
    <name>A3FQR0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L29</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAZ51211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388186.1">
        <property type="nucleotide sequence ID" value="XM_001388149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQR0"/>
    <dbReference type="FunCoup" id="A3FQR0">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQR0"/>
    <dbReference type="GeneID" id="3372352"/>
    <dbReference type="KEGG" id="cpv:cgd2_120"/>
    <dbReference type="InParanoid" id="A3FQR0"/>
    <dbReference type="OMA" id="PRTNKYP"/>
    <dbReference type="OrthoDB" id="996720at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002673">
        <property type="entry name" value="Ribosomal_eL29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12884:SF0">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01779">
        <property type="entry name" value="Ribosomal_L29e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="68" mass="7686" checksum="1F637D8B48E82246" modified="2007-04-03" version="1">MAKSKNHTNHNQVNRKAHRNGIKKAKSYRKLPTFGMNAKFLKNQRFCKKVAMKEAAAKAAAAKKALFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPG8</accession>
    <name>Q5CPG8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Asparagine synthetase B like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625325.1">
        <property type="nucleotide sequence ID" value="XM_625325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPG8"/>
    <dbReference type="STRING" id="353152.Q5CPG8"/>
    <dbReference type="GeneID" id="3372316"/>
    <dbReference type="KEGG" id="cpv:cgd3_110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_110"/>
    <dbReference type="InParanoid" id="Q5CPG8"/>
    <dbReference type="OMA" id="VELRFIC"/>
    <dbReference type="OrthoDB" id="10252281at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004066">
        <property type="term" value="F:asparagine synthase (glutamine-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006529">
        <property type="term" value="P:asparagine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01991">
        <property type="entry name" value="Asn_synthase_B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001962">
        <property type="entry name" value="Asn_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051857">
        <property type="entry name" value="Asn_synthetase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45937:SF1">
        <property type="entry name" value="ASPARAGINE SYNTHETASE DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="2" id="KW-0061">Asparagine biosynthesis</keyword>
    <keyword evidence="3" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="719" mass="83049" checksum="56DB7F008B582546" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPH0</accession>
    <name>Q5CPH0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">SEA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_90</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625323.1">
        <property type="nucleotide sequence ID" value="XM_625323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPH0"/>
    <dbReference type="GeneID" id="3372318"/>
    <dbReference type="KEGG" id="cpv:cgd3_90"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_90"/>
    <dbReference type="InParanoid" id="Q5CPH0"/>
    <dbReference type="OMA" id="PHTENSA"/>
    <dbReference type="OrthoDB" id="343962at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253704" description="SEA domain-containing protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="245"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="367"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="371"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="740" mass="84823" checksum="E455E1EEB0B2187A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPH5</accession>
    <name>Q5CPH5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_30</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625318.1">
        <property type="nucleotide sequence ID" value="XM_625318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPH5"/>
    <dbReference type="GeneID" id="3372323"/>
    <dbReference type="KEGG" id="cpv:cgd3_30"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_30"/>
    <dbReference type="InParanoid" id="Q5CPH5"/>
    <dbReference type="OrthoDB" id="341821at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="162"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="262"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="314"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="442" mass="51121" checksum="05EEED89CADF2B39" modified="2005-04-12" version="1">MEKIIKSDYDSLLEIDLYSEDEVDGDLIITDNIFMYDQICYLKNCLVVLLLIWHFLHAIIFGGDISPSITRFKIGDNGIFALVLNILVPCIFFVQGWLKAFEIHKQTSFIKRLHIEFLIPIFIYVLFYLVSILFKNDTHLENLTNEEFGNLLSKSGYFNPGFLSTFLLLFLINLVLDSTALVIVPHFYVNNSLIFYKVNNSLISRNYKSGNVSNEMDRKYFSVLKNFSFYKLIYCLLMVLLYDSLLDFLNNMEPKNLIHKSKISNIFSVLILLIMCKIFKNSPRIFYYVCFIGSFINLIICSSFGSYINCHFSASLISSFHFLLNVFFTGTLISCMNLEIFKKWQFSIFFTLCSVLCHFTSADYSRSIISPLIFPSIFSIKSRFLTVSQIFSSIFAILSISIQLFKCFSSKSKTKSLRAINSTILLCFSLMLCISSIKLFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ21</accession>
    <name>Q5CQ21_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 11">Thymidine kinase</fullName>
            <ecNumber evidence="2 11">2.7.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd5_4440</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>thymidine + ATP = dTMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19129"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17748"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the thymidine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.21" evidence="2 11"/>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625605.1">
        <property type="nucleotide sequence ID" value="XM_625605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ21"/>
    <dbReference type="STRING" id="353152.Q5CQ21"/>
    <dbReference type="GeneID" id="3372560"/>
    <dbReference type="KEGG" id="cpv:cgd5_4440"/>
    <dbReference type="InParanoid" id="Q5CQ21"/>
    <dbReference type="OMA" id="GTMDCGK"/>
    <dbReference type="OrthoDB" id="439028at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004797">
        <property type="term" value="F:thymidine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046104">
        <property type="term" value="P:thymidine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000323">
        <property type="entry name" value="Thymidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00124">
        <property type="entry name" value="Thymidine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001267">
        <property type="entry name" value="Thymidine_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003300">
        <property type="entry name" value="PRK04296.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441">
        <property type="entry name" value="THYMIDINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11441:SF0">
        <property type="entry name" value="THYMIDINE KINASE, CYTOSOLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00265">
        <property type="entry name" value="TK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF035805">
        <property type="entry name" value="TK_cell"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0237">DNA synthesis</keyword>
    <keyword evidence="7 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="6 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="177"/>
            <end position="180"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR035805-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK87600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="202" mass="23313" checksum="91A9ABEA061E3263" modified="2005-04-12" version="1" fragment="single">DWKYFNKMAKLYFYYSAMNAGKSTVLLQSSFNYQERGMKTILFTISKDCRFEEGSICSRIGLSEKAHTFTPDLKLLDIINQENNKEKIDCVLVDESQFLTKFQVRELCIVVDKLNIPVLCYGLRTDFKGNLFEGSKYLLAWADKLTEIKTICRCGKKATMTIRLNSNGEPVFSGEQILIGDNSIYTSVCRKHHIINCEEYNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ27</accession>
    <name>Q5CQ27_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase S9 prolyl oligopeptidase catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_4370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625599.1">
        <property type="nucleotide sequence ID" value="XM_625599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ27"/>
    <dbReference type="STRING" id="353152.Q5CQ27"/>
    <dbReference type="ESTHER" id="crypv-q5cq27">
        <property type="family name" value="ACPH_Peptidase_S9"/>
    </dbReference>
    <dbReference type="GeneID" id="3372583"/>
    <dbReference type="KEGG" id="cpv:cgd5_4370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4370"/>
    <dbReference type="InParanoid" id="Q5CQ27"/>
    <dbReference type="OMA" id="WNKDSTH"/>
    <dbReference type="OrthoDB" id="416344at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776:SF4">
        <property type="entry name" value="ACYLAMINO-ACID-RELEASING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42776">
        <property type="entry name" value="SERINE PEPTIDASE S9 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="583"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="810" mass="90174" checksum="22DA9BEF21B2F64A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ70</accession>
    <name>Q5CQ70_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Calmodulin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_3920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625556.1">
        <property type="nucleotide sequence ID" value="XM_625556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ70"/>
    <dbReference type="SMR" id="Q5CQ70"/>
    <dbReference type="STRING" id="353152.Q5CQ70"/>
    <dbReference type="GeneID" id="3372599"/>
    <dbReference type="KEGG" id="cpv:cgd5_3920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3920"/>
    <dbReference type="InParanoid" id="Q5CQ70"/>
    <dbReference type="OMA" id="TRRSVIM"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="108"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="145"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="182"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="220" mass="25059" checksum="227059C48B6785FF" modified="2005-04-12" version="1">MSESSNIRNGNATVKISALYGEEQFCPIVGDTKEKSMETNTRRIPFGMTELTLEHEAALKGLFDTLNTYGDGKIRLNDLIIALRRAFDNGTVTFSRHEASAAEITGEHIDSELEKLKEDFDMNGDGTLDFDEFRRLARMKILRLSRDDEIQLGFRLLDRNNSGYITTLELKQLLTTKGISPLTSEEADELLFIADVDHDGLISYDEIKRYLEYNRRPLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQC3</accession>
    <name>Q5CQC3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_1280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625725.1">
        <property type="nucleotide sequence ID" value="XM_625725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQC3"/>
    <dbReference type="STRING" id="353152.Q5CQC3"/>
    <dbReference type="GeneID" id="3372646"/>
    <dbReference type="KEGG" id="cpv:cgd4_1280"/>
    <dbReference type="InParanoid" id="Q5CQC3"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="101" mass="11517" checksum="7B58CCE90099694B" modified="2005-04-12" version="1">MGGDGGSIPKRADVVKTKGYGFKRNLGGMGYMPNAQVKLTNEENSTKLKMHERWTKCYLTNVSLSFHCTFFYKTSSLFSLAFSTYLNIYYEIPNDTNLHIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQK8</accession>
    <name>Q5CQK8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625640.1">
        <property type="nucleotide sequence ID" value="XM_625640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQK8"/>
    <dbReference type="GeneID" id="3372739"/>
    <dbReference type="KEGG" id="cpv:cgd4_330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_330"/>
    <dbReference type="InParanoid" id="Q5CQK8"/>
    <dbReference type="OrthoDB" id="338837at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="152" mass="17641" checksum="0241CD0C42ECBC8E" modified="2005-04-12" version="1">MQEHEEKEIQFPTHLVELALQEQEVKDQIWVLISGGDKNKTISFSELEKLSEALGLNLCEEEINSMLFWGKYGNNKDFKKIQNSWLEIQTGSSNLQGSEHDSKVESDSEASNDLESLRNIEINYTDFCEIFARNERSCKRRIAKKIDLRNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQL8</accession>
    <name>Q5CQL8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ubc1p like ubiquitin-conjugating enzyme E2 fused to a UBA domain (UBC+UBA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd4_210</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625630.1">
        <property type="nucleotide sequence ID" value="XM_625630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQL8"/>
    <dbReference type="FunCoup" id="Q5CQL8">
        <property type="interactions" value="477"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQL8"/>
    <dbReference type="GeneID" id="3372664"/>
    <dbReference type="KEGG" id="cpv:cgd4_210"/>
    <dbReference type="InParanoid" id="Q5CQL8"/>
    <dbReference type="OMA" id="HWTFVYA"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14314">
        <property type="entry name" value="UBA_II_E2_pyUCE_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23800">
        <property type="entry name" value="UBCc_UBE2K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="8">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="7">
        <location>
            <begin position="156"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="197" mass="22782" checksum="1AC12CA935F0A777" modified="2005-04-12" version="1" fragment="single">LIFYYKYLKELRGLQVFTDELEEDKQVGIKLIGNRNDNFLGIIRGPIGTPYEGGIFQLDIIVPKEYPYEPPKVKFITRIWHPNISSQTGAICLDILKDAWSPALTLRTVMLSIQALLSSPEPNDPQDALVASLYKSDYQEYIETAKSWTQMYAKPTSKEERIKRFLDMGFNRESIITALERNNWDENLALNELLFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQM6</accession>
    <name>Q5CQM6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RRM domain and KH domain protein (SPAC30D11.14-like KH)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625622.1">
        <property type="nucleotide sequence ID" value="XM_625622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQM6"/>
    <dbReference type="STRING" id="353152.Q5CQM6"/>
    <dbReference type="GeneID" id="3372723"/>
    <dbReference type="KEGG" id="cpv:cgd4_130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_130"/>
    <dbReference type="InParanoid" id="Q5CQM6"/>
    <dbReference type="OMA" id="NNDRWIN"/>
    <dbReference type="OrthoDB" id="5989967at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22386">
        <property type="entry name" value="KH-I_KHDC4_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000037">
        <property type="entry name" value="KH domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047889">
        <property type="entry name" value="KHDC4_KH-I_second"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031121">
        <property type="entry name" value="RIK/BLOM7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744">
        <property type="entry name" value="BLOM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15744:SF0">
        <property type="entry name" value="KH HOMOLOGY DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KHDC4/BBP-like KH-domain type I" evidence="2">
        <location>
            <begin position="649"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="211"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="590"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="482"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="599"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="761"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="801" mass="90007" checksum="678B530889DCABAE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQM9</accession>
    <name>Q5CQM9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA-processing protein 7 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_90</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87705.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625619.1">
        <property type="nucleotide sequence ID" value="XM_625619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQM9"/>
    <dbReference type="STRING" id="353152.Q5CQM9"/>
    <dbReference type="GeneID" id="3372605"/>
    <dbReference type="KEGG" id="cpv:cgd4_90"/>
    <dbReference type="InParanoid" id="Q5CQM9"/>
    <dbReference type="OMA" id="NCDKSIE"/>
    <dbReference type="OrthoDB" id="5390at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032545">
        <property type="term" value="C:CURI complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034456">
        <property type="term" value="C:UTP-C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040446">
        <property type="entry name" value="RRP7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024326">
        <property type="entry name" value="RRP7_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13191:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 7 HOMOLOG A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12923">
        <property type="entry name" value="RRP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 7 C-terminal" evidence="2">
        <location>
            <begin position="70"/>
            <end position="173"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87705.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="176" mass="20807" checksum="D2BA52D9EA0356AE" modified="2005-04-12" version="1">MGIKTSETGSENSWVYIVFNEIDSIQKIKDDSIINNKDSIRKLYINDSSNFLLGRSDLRFKNILMRITNKRVNSTLLQREVDSYMTNYDIEREIEEENLKLESTIPDEDGFIKVVNKKQKAPDGTVIHSFESNKTTQGFNTKKQINKKEKKKTYNDFYRFQIRENKKKEIQKLNYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQW9</accession>
    <name>Q5CQW9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RhoGAP domain containing protein with a Sec14D domain at the N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625883.1">
        <property type="nucleotide sequence ID" value="XM_625883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQW9"/>
    <dbReference type="FunCoup" id="Q5CQW9">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQW9"/>
    <dbReference type="GeneID" id="3372970"/>
    <dbReference type="KEGG" id="cpv:cgd4_2980"/>
    <dbReference type="InParanoid" id="Q5CQW9"/>
    <dbReference type="OMA" id="SHNPDCD"/>
    <dbReference type="OrthoDB" id="19923at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00159">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.555.10">
        <property type="entry name" value="Rho GTPase activation protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008936">
        <property type="entry name" value="Rho_GTPase_activation_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000198">
        <property type="entry name" value="RhoGAP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45808:SF2">
        <property type="entry name" value="RHO GTPASE-ACTIVATING PROTEIN 68F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13716">
        <property type="entry name" value="CRAL_TRIO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00620">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00324">
        <property type="entry name" value="RhoGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48350">
        <property type="entry name" value="GTPase activation domain, GAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50238">
        <property type="entry name" value="RHOGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rho-GAP" evidence="2">
        <location>
            <begin position="171"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="394"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="440" mass="50135" checksum="ED2915E0E86E3510" modified="2005-04-12" version="1" fragment="single">KSILSYEETRFIFYLGDDVLQRPVIMLVSCFLPPTVDELDKAMRYAVHYTKEFVRTEFIIIQCLTRTNILSDGSSNFLQQFYSLLPTEYKKNLKKVIMFHYGVSNRALLTITSSYMSPRFMRKLEYADSIRELYRFIPDISEEELLNRLPFIVKHDDAELLGLEAPALLSMSLLEQCICNGYNVPGYGKIPAVIVDFVQKLSKPDIVIIPNLFSLQTSADKLTSIIGEVDSGVPFRSADSDPSTLVSAFKLILNSLDEPLLGSETFHSIVRQCKSSGTHELAHSFYINFLKETISKLPDSSKLVIKFLVDFLHFVSTKSSINNMTAHKIAEILSPAFCRPNSMKNITMFQSIPPCVECITVLISDCQSIFNNILPDINSFDHLREVKENLRKKQLEEAEEEEEAEEVEGEEEEEEEEEEEGQPELLGTEDKDEVESEENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQY4</accession>
    <name>Q5CQY4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mra1/NEP1 like protein, involved in pre-rRNA processing, adjacent genes putative paralogs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd4_2830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625868.1">
        <property type="nucleotide sequence ID" value="XM_625868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQY4"/>
    <dbReference type="STRING" id="353152.Q5CQY4"/>
    <dbReference type="GeneID" id="3372975"/>
    <dbReference type="KEGG" id="cpv:cgd4_2830"/>
    <dbReference type="InParanoid" id="Q5CQY4"/>
    <dbReference type="OMA" id="KFTHYIS"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="216" mass="24355" checksum="5DB6DB3D49CCE239" modified="2005-04-12" version="1" fragment="single">LFNFWKNSSLFVNKNNGKKELLTEEKVLERDMKLIDSDEFRPDIIHNSLLMLLDSPLCKSGCLSDILILNLDGKLIRVSPKFRVPRSFKVFSKVFSEFLSSPNGELKLPDEENTVLISLLNSSIEEYLSNSEVVVGLSRMAKKVSLQEFCRNEIATKIRNGADNINFVIGASATNNSCGQFTSKFTHYISLSDVSMPSYICCTKICSEMEELLGIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR47</accession>
    <name>Q5CR47_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625805.1">
        <property type="nucleotide sequence ID" value="XM_625805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR47"/>
    <dbReference type="STRING" id="353152.Q5CR47"/>
    <dbReference type="GeneID" id="3372959"/>
    <dbReference type="KEGG" id="cpv:cgd4_2130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2130"/>
    <dbReference type="InParanoid" id="Q5CR47"/>
    <dbReference type="OMA" id="HPNLYEH"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="31"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="308"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="342" mass="39781" checksum="8B8CE8D6F1473FDD" modified="2005-04-12" version="1">MIGSIDFWNKEAKAPLLKRNAGMFSSKLKEMVPHINRAESWLDIALNPNNDIKQLNESGNEINCNNDSLIQLDQNIEINLVDHTDNPEIDRIFKLDAERTFSDEENRIKMITVLSTIYQEIKDYHQGLGFVVAFFLLQLTPEDTVRLALSLNRYYLPGYFKTAPFNYVRDAKVFEKLLMKRYPDAAKKIEESACAEAFCSKWFVGLNVHVLPFPSLCKFFEILFEKGNLFLFQFGLSIVDVCREDILNAKDASQVLAILRLDEKVYHDLLEHKDFLGKEEERAGSFFLHLVDNALDIEITQDEVNNLREIVLEEMMQQEEKRKQIESQMNFDEDEIVFSDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR75</accession>
    <name>Q5CR75_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Dynein light chain tctex1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625777.1">
        <property type="nucleotide sequence ID" value="XM_625777.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR75"/>
    <dbReference type="FunCoup" id="Q5CR75">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR75"/>
    <dbReference type="GeneID" id="3372904"/>
    <dbReference type="KEGG" id="cpv:cgd4_1830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1830"/>
    <dbReference type="InParanoid" id="Q5CR75"/>
    <dbReference type="OMA" id="VNQWTSA"/>
    <dbReference type="OrthoDB" id="10059120at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21455">
        <property type="entry name" value="DLC-like_DYNLT1_DYNLT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.40">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005334">
        <property type="entry name" value="Tctex-1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038586">
        <property type="entry name" value="Tctex-1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255:SF4">
        <property type="entry name" value="DYNEIN LIGHT CHAIN TCTEX-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21255">
        <property type="entry name" value="T-COMPLEX-ASSOCIATED-TESTIS-EXPRESSED 1/ DYNEIN LIGHT CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03645">
        <property type="entry name" value="Tctex-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="151" mass="16561" checksum="1F76F1A746B1888D" modified="2005-04-12" version="1">MSSSSNLGSDPSNPTNKSTENPVGGTAEHDFDPNSMPNGQISSISSFSSIKDGVQDCIITSINSVLDQSTEYNASEVTTWVDSITSQCLENLRKLSEKFKYIVSVIVLQRSPAGFHLFTTCYWDQANDGSVTHRWDNKNLHCVVVVYGVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRD8</accession>
    <name>Q5CRD8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_3200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626248.1">
        <property type="nucleotide sequence ID" value="XM_626248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRD8"/>
    <dbReference type="SMR" id="Q5CRD8"/>
    <dbReference type="FunCoup" id="Q5CRD8">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRD8"/>
    <dbReference type="GeneID" id="3373041"/>
    <dbReference type="KEGG" id="cpv:cgd5_3200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3200"/>
    <dbReference type="InParanoid" id="Q5CRD8"/>
    <dbReference type="OMA" id="WYHSIGL"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="90"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="683" mass="77128" checksum="E5818BCEA2352DA1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRH7</accession>
    <name>Q5CRH7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626209.1">
        <property type="nucleotide sequence ID" value="XM_626209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRH7"/>
    <dbReference type="STRING" id="353152.Q5CRH7"/>
    <dbReference type="GeneID" id="3373233"/>
    <dbReference type="KEGG" id="cpv:cgd5_2730"/>
    <dbReference type="InParanoid" id="Q5CRH7"/>
    <dbReference type="OMA" id="ICECNLM"/>
    <dbReference type="OrthoDB" id="340310at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="429"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="456" mass="53884" checksum="D02AEF400C07423E" modified="2005-04-12" version="1">MYKNCIYGFLLLTKNGKVSPILYVRTLVYKLGNRYYFDLGEIQDEKERENAKLVKLQVGQAIHLFCMKGSSLFYSRDETKPLDSKIKKELARLEEQEQEQEQEQELGQEHQERLDDNIKERPEMVEIMLYLTELLDSEILSVEIDKAMMNGRRKEIKDIWKIGKERRLDQEKINEYKNMVKLIRIPLPESRLRDRYGQIHHPDSENKLGVPTRIQKESDKIKSKLNQIKRDENILMGVGNERFVDYERRKYLEAALKRNQKLSFEKNKQIISDRRNEDKQDEESRLKCECEEEECECRIVGLYGEVLGKPVSIKLEEELFNDHQIFGNKNKNRKNEIKHFKGLITGTREENRKYKGNNEYQDNSTGSNLRRKLHVPNSYIEIPLRGLSKLQLLTLEQLSGIDINTRSSTQFLPRIKKINHEKNIKVSESVPINEDDKGSSIKKPKSILHNRNRNYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRI5</accession>
    <name>Q5CRI5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Little finger (CxxC...CxxC) domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_2640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626201.1">
        <property type="nucleotide sequence ID" value="XM_626201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRI5"/>
    <dbReference type="GeneID" id="3373220"/>
    <dbReference type="KEGG" id="cpv:cgd5_2640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2640"/>
    <dbReference type="InParanoid" id="Q5CRI5"/>
    <dbReference type="OrthoDB" id="1878647at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036443">
        <property type="entry name" value="Znf_RanBP2_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00547">
        <property type="entry name" value="ZnF_RBZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90209">
        <property type="entry name" value="Ran binding protein zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="6">
        <location>
            <begin position="542"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="271"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="340"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="434"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="602"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="704"/>
            <end position="737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="31"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="271"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="446"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="704"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="720"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="737" mass="76791" checksum="FF3A1E0BA12864EA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRJ0</accession>
    <name>Q5CRJ0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">dolichyl-phosphate beta-glucosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.117</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd5_2590</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-alpha-D-glucose = a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate + UDP</text>
            <dbReference type="Rhea" id="RHEA:15401"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19502"/>
            <dbReference type="ChEBI" id="CHEBI:57525"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="EC" id="2.4.1.117"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:15402"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.117" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626196.1">
        <property type="nucleotide sequence ID" value="XM_626196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRJ0"/>
    <dbReference type="STRING" id="353152.Q5CRJ0"/>
    <dbReference type="GeneID" id="3373161"/>
    <dbReference type="KEGG" id="cpv:cgd5_2590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2590"/>
    <dbReference type="InParanoid" id="Q5CRJ0"/>
    <dbReference type="OMA" id="PQPLPCW"/>
    <dbReference type="OrthoDB" id="3784at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004581">
        <property type="term" value="F:dolichyl-phosphate beta-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04188">
        <property type="entry name" value="DPG_synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035518">
        <property type="entry name" value="DPG_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859:SF91">
        <property type="entry name" value="DOLICHYL-PHOSPHATE BETA-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10859">
        <property type="entry name" value="GLYCOSYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="16"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="85"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00045097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK87979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="362" mass="41882" checksum="A3D3C5E5FF614B7E" modified="2005-04-12" version="1">MHFKGDIWKVIFKHRMLFVSFLVLGLALVTYILIGSYKIKSEPDDDKVIRQVFYSQNYEISKEADKESWNTISGNILKDSELYLSIVIPAFNEEDRILKNLSSMVYYMESRNREDPKFIYEIILVNDGGSDDTLKICEDFWRQKIQNKEIIGGRMRLLSSLVNKGKGFAVKIGVMASLGKYILMADADGATKIDCFSKMEDIILSKDEQQQIIFGSRNINALSEDNVSNIERAWYRQILNTAFHKIMKVIINTNLNDTQCGFKLFSRRLARVIFPSLHIKRWAFDIEIVIIAQILNLEIQPVSVDWKEVQGSKLSVFSDSIKMLLDILILKSFYILHIWKVKDHSLLGRPCEKPVPTYRKTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRK1</accession>
    <name>Q5CRK1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin domain at the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626185.1">
        <property type="nucleotide sequence ID" value="XM_626185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRK1"/>
    <dbReference type="GeneID" id="3373154"/>
    <dbReference type="KEGG" id="cpv:cgd5_2480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2480"/>
    <dbReference type="InParanoid" id="Q5CRK1"/>
    <dbReference type="OMA" id="SCTHEDQ"/>
    <dbReference type="OrthoDB" id="341994at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd09917">
        <property type="entry name" value="F-box_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01763">
        <property type="entry name" value="Ubl_SUMO_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad60/SUMO-like" evidence="2">
        <location>
            <begin position="991"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="797"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="859"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="859"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1074" mass="121688" checksum="E4A9DE06E12885C8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRP5</accession>
    <name>Q5CRP5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd5_2000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626141.1">
        <property type="nucleotide sequence ID" value="XM_626141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRP5"/>
    <dbReference type="FunCoup" id="Q5CRP5">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRP5"/>
    <dbReference type="GeneID" id="3373266"/>
    <dbReference type="KEGG" id="cpv:cgd5_2000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2000"/>
    <dbReference type="InParanoid" id="Q5CRP5"/>
    <dbReference type="OMA" id="RREHKIP"/>
    <dbReference type="OrthoDB" id="205248at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05147">
        <property type="entry name" value="RIO1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051272">
        <property type="entry name" value="RIO-type_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45723">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="13">
        <location>
            <begin position="46"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="606"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="630"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="12">
        <location>
            <begin position="649"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK88067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="668" mass="77375" checksum="6E6622581F381DDE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS19</accession>
    <name>Q5CS19_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626017.1">
        <property type="nucleotide sequence ID" value="XM_626017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS19"/>
    <dbReference type="SMR" id="Q5CS19"/>
    <dbReference type="STRING" id="353152.Q5CS19"/>
    <dbReference type="GeneID" id="3373169"/>
    <dbReference type="KEGG" id="cpv:cgd5_600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_600"/>
    <dbReference type="InParanoid" id="Q5CS19"/>
    <dbReference type="OMA" id="NMHERLH"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="41"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="418" mass="47840" checksum="AB37E43E18CFA3DB" modified="2005-04-12" version="1">MKTIIFEPGRTICKGGNSENLLPTVEVPSVCFLKNFEKEGNENKLSELNNLQETNKNIRNLKSNILSKDELKRIVLVGNEAIKSLESTNGNLIYPLHRNLVMSDWLLCELIWEQVLLELGVKTKIEKFKNKKLSSESGSESENQVLMVILPSTGGILIKEKVNEWLKENYDFNQVTFIPAYLLTLYSYGKETGIVVDIGSFWTNITPVIEGVSDDNYSLSIPIGGRSLEEYMKILLSRRGLKFSGKKDTKFIEETKDDLLVRNILSENCFVSTDEKNTREIISYTTSYLELIRVNSKLNNSKSIFLEEERFQVTENVFFKPYKIGIESPSICEAILKVINKCPLDTRTLLMENIFLTGRSSLFIGLPQRIQVNLTQLFLDSKLRGDTNRLNKYKFYVNDDPMRDVSTFKGANIYLQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS28</accession>
    <name>Q5CS28_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Pru domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_480</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626008.1">
        <property type="nucleotide sequence ID" value="XM_626008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS28"/>
    <dbReference type="FunCoup" id="Q5CS28">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS28"/>
    <dbReference type="GeneID" id="3373177"/>
    <dbReference type="KEGG" id="cpv:cgd5_480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_480"/>
    <dbReference type="InParanoid" id="Q5CS28"/>
    <dbReference type="OMA" id="WMQDYDD"/>
    <dbReference type="OrthoDB" id="340431at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061133">
        <property type="term" value="F:endopeptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.2020.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.70">
        <property type="entry name" value="Proteasomal ubiquitin receptor Rpn13/ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006773">
        <property type="entry name" value="Rpn13/ADRM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044868">
        <property type="entry name" value="Rpn13/ADRM1_Pru"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038633">
        <property type="entry name" value="Rpn13/ADRM1_Pru_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032368">
        <property type="entry name" value="RPN13_DEUBAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038108">
        <property type="entry name" value="RPN13_DEUBAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225">
        <property type="entry name" value="ADHESION REGULATING MOLECULE 1 110 KDA CELL MEMBRANE GLYCOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12225:SF0">
        <property type="entry name" value="PROTEASOMAL UBIQUITIN RECEPTOR ADRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04683">
        <property type="entry name" value="Rpn13_ADRM1_Pru"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16550">
        <property type="entry name" value="RPN13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51917">
        <property type="entry name" value="PRU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pru" evidence="6">
        <location>
            <begin position="3"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="240" mass="28102" checksum="52DBD073BA823F31" modified="2005-04-12" version="1">MQESIHVIKEYKVGKMTWDGKIVKACTDKGKLQFIKELDGNTHKIRWYNIDKEINEDEIIVENEINFDIIKESKSNNVFVLKKNSKPLSIYWIQDSKLILDDLINDLNTQIKLITNNLNETIRSVLEQMNNNNNNKRRISLSEILTSEIINELKQDQDLIEELKEHMPSNQRNLQDINSVINCPQVKYTMRLLDESIYSEQIFTLSTALGLDINFDSLINKNPMQVFINALNKKYNPEEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS86</accession>
    <name>Q5CS86_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">CDC20/Fizzy WD40 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_3700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat CDC20/Fizzy family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628181.1">
        <property type="nucleotide sequence ID" value="XM_628181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS86"/>
    <dbReference type="SMR" id="Q5CS86"/>
    <dbReference type="FunCoup" id="Q5CS86">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS86"/>
    <dbReference type="GeneID" id="3371516"/>
    <dbReference type="KEGG" id="cpv:cgd1_3700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3700"/>
    <dbReference type="InParanoid" id="Q5CS86"/>
    <dbReference type="OMA" id="FHHEYEK"/>
    <dbReference type="OrthoDB" id="10263272at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010997">
        <property type="term" value="F:anaphase-promoting complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990757">
        <property type="term" value="F:ubiquitin ligase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1905786">
        <property type="term" value="P:positive regulation of anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033010">
        <property type="entry name" value="Cdc20/Fizzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056150">
        <property type="entry name" value="WD40_CDC20-Fz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918">
        <property type="entry name" value="CELL DIVISION CYCLE 20 CDC20 FIZZY -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19918:SF1">
        <property type="entry name" value="FIZZY-RELATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24807">
        <property type="entry name" value="WD40_CDC20-Fz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CDC20/Fizzy WD40" evidence="6">
        <location>
            <begin position="138"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="266"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="308"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="396"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF24807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="453" mass="50252" checksum="C40A99DE9A8115A1" modified="2005-04-12" version="1">MNSLSLSHSLGKSYLFERYSRFGMSDSIIQRNFQNPVSVYNELLATELLPTTESDFSAMVKLRVGSQSMGVQERRKLGSKKLYGDENEYSRLNSCEVFDPFATVPLRSVSMDPAWLSSTNMGMGPISRKIPKGPFKILDAPNLQDDFYLNLVDWSSTNLLAVGLSSSVYLWSASTCKVTNLLNLQDQDTVTSVSWTQQGNHLAVGTRQGSVQIWDVVEQKKVRTLNGHRARIGAMDWCGPILATGGRDHTVLLRDVREQEHWCSRWLGHKQEVCGVKWSPNEMQLATGGNDNKLLIWSQGYDTPVCQFQEHTAAVKALSWNPHQSGLLASGGGTADRHIRIWNTVTNSCVMAVDTGSQVCNIAWSGNVNELVSTHGYSLNQVILWKWPSMQKIATLTGHTYRVLYLAVSPDGQTIVTGAGDETLRFWQIFPTGRPKGPKNLAALSVPNAPAMR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSH3</accession>
    <name>Q5CSH3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase II B3 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_2710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628094.1">
        <property type="nucleotide sequence ID" value="XM_628094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSH3"/>
    <dbReference type="FunCoup" id="Q5CSH3">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSH3"/>
    <dbReference type="GeneID" id="3371688"/>
    <dbReference type="KEGG" id="cpv:cgd1_2710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2710"/>
    <dbReference type="InParanoid" id="Q5CSH3"/>
    <dbReference type="OMA" id="DETKFHF"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07031">
        <property type="entry name" value="RNAP_II_RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF2">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="4">
        <location>
            <begin position="21"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="355" mass="39083" checksum="38D32322CF29CD87" modified="2005-04-12" version="1">MMLGKGMRSPKAEITELTPNSIRFTLSNTDLSMANTLRRIILAEIPTLAIDLVTMIDNTSVLHDEFIVHRMGLIPLDSTNIRDFNFKDRCECQERCNKCSVEYLLDVTCEGGATRNVTHYDIQPVATSTLVPMPVPKKDDSVDGMNNGILIAKLGPGQRIAMRMTACKGIGKFHAKWIPVSVATFTNEADVRINYSLSSNLTLKQRKEIVNCCPKDVFALGGSTSKTEYALNKNSAYSTKTKTEELPDLEVVSSKSCIFCNECVNLTKNYGYINPVLIRVDTKPDKFHFLVESTGALPVESIVELAFEILQEKLNTLSRGVARSETAQSGLDTNGSGGVNITADERAMDLVLDLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSK3</accession>
    <name>Q5CSK3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_2340</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628064.1">
        <property type="nucleotide sequence ID" value="XM_628064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSK3"/>
    <dbReference type="GeneID" id="3371670"/>
    <dbReference type="KEGG" id="cpv:cgd1_2340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2340"/>
    <dbReference type="InParanoid" id="Q5CSK3"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003021">
        <property type="entry name" value="Rad1_Rec1_Rad17"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10870:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02144">
        <property type="entry name" value="Rad1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="181" mass="20480" checksum="7C177AE132A5241D" modified="2005-04-12" version="1">MEACLFDVQSLVKTIQSLQLSKANKKNGEGQFLTCMISAQGIKLSNSTLSKDVYCCSWLRKNIFKKYLYEASQTNCSRFEICLGTILNCIQVFGLDAKMVILTYDHVSLHLSITDDDGAVTDCSLCTYNISEETNEFYYSNFLDCKNVAIFDLDYVTMFPIILRELLKDLCDVGRSESKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSR7</accession>
    <name>Q5CSR7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Histidine triad (HIT) family zinc binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_1600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628000.1">
        <property type="nucleotide sequence ID" value="XM_628000.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSR7"/>
    <dbReference type="FunCoup" id="Q5CSR7">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSR7"/>
    <dbReference type="GeneID" id="3371361"/>
    <dbReference type="KEGG" id="cpv:cgd1_1600"/>
    <dbReference type="InParanoid" id="Q5CSR7"/>
    <dbReference type="OMA" id="YRVVMNC"/>
    <dbReference type="OrthoDB" id="672793at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01276">
        <property type="entry name" value="PKCI_related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.428.10">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019808">
        <property type="entry name" value="Histidine_triad_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001310">
        <property type="entry name" value="Histidine_triad_HIT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011146">
        <property type="entry name" value="HIT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036265">
        <property type="entry name" value="HIT-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23089">
        <property type="entry name" value="HISTIDINE TRIAD HIT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01230">
        <property type="entry name" value="HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00332">
        <property type="entry name" value="HISTRIAD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54197">
        <property type="entry name" value="HIT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00892">
        <property type="entry name" value="HIT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51084">
        <property type="entry name" value="HIT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HIT" evidence="4">
        <location>
            <begin position="21"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Histidine triad motif" evidence="2 3">
        <location>
            <begin position="114"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Tele-AMP-histidine intermediate" evidence="1">
        <location>
            <position position="116"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR601310-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="130" mass="14569" checksum="C5930820338BA45A" modified="2005-04-12" version="1" fragment="single">VDLDFLHITVFGSMVDSEVTIFDRIVSGEIPCRKIYEDDLCISFHDINPVAPVHALLVPKKRSGLTRLSKATETHKEILGHLMTKVPVVAKLLDLDDFRIVINDGESSCQTVFHLHIHILGGRNFTWPPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CST8</accession>
    <name>Q5CST8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein with 3x EFh domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_1370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627979.1">
        <property type="nucleotide sequence ID" value="XM_627979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CST8"/>
    <dbReference type="FunCoup" id="Q5CST8">
        <property type="interactions" value="143"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CST8"/>
    <dbReference type="GeneID" id="3371526"/>
    <dbReference type="KEGG" id="cpv:cgd1_1370"/>
    <dbReference type="InParanoid" id="Q5CST8"/>
    <dbReference type="OMA" id="DTNFDRD"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45942">
        <property type="entry name" value="PROTEIN PHOSPATASE 3 REGULATORY SUBUNIT B ALPHA ISOFORM TYPE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="105"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="146"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="189" mass="21569" checksum="6384F382E2A9B8B0" modified="2005-04-12" version="1" fragment="single">SFCTKLIAKLMLRNESSGISEQEKLELVHAASFTRRDIIRIYSRFKALDTNQNGELDPHELFEMPEIADNPLVKRVISIFDTNKDGKVSFVEFIIGLARLAVGSNPEEKMKFAFDIYDVNSDGWISNGELFKVMKIMVGDNLEDLQLQQLVDRCIIQADKDGDGLISYEEFCEMVAHLDINTKLNLQFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSW7</accession>
    <name>Q5CSW7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_1050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627950.1">
        <property type="nucleotide sequence ID" value="XM_627950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSW7"/>
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        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSW7"/>
    <dbReference type="GeneID" id="3371551"/>
    <dbReference type="KEGG" id="cpv:cgd1_1050"/>
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    <dbReference type="InParanoid" id="Q5CSW7"/>
    <dbReference type="OMA" id="LSYWVIC"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="145" mass="17039" checksum="0C8FD1DB0A07FF47" modified="2005-04-12" version="1">MTFSIIPFPKIISFMLQYLYPLVGTANVTFDFGKKDIPVFELTNLLFYWIICGVIFMIESIVGIVTKIPFYYDLKIMVLLWLILPVFSGSGYIYYMYIHELINNGLESHFSKVSHKLKAFKSSLLEFSNSPKARKSYKNRKYFKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT12</accession>
    <name>Q5CT12_CRYPI</name>
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        <submittedName>
            <fullName evidence="2">Predicted secreted protein, signal peptide, low complexity serine-threonine rich, possible mucin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_627905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT12"/>
    <dbReference type="STRING" id="353152.Q5CT12"/>
    <dbReference type="GeneID" id="3371546"/>
    <dbReference type="KEGG" id="cpv:cgd1_470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_470"/>
    <dbReference type="InParanoid" id="Q5CT12"/>
    <dbReference type="OMA" id="WRMISES"/>
    <dbReference type="OrthoDB" id="344323at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="885"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="276"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="317"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="410"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="458"/>
            <end position="478"/>
        </location>
    </feature>
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        <location>
            <begin position="479"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="671"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="701"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="887"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="932" mass="97962" checksum="67C640934073F4E8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT20</accession>
    <name>Q5CT20_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Carboxypeptidase probably secreted, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the peptidase M14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627897.1">
        <property type="nucleotide sequence ID" value="XM_627897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT20"/>
    <dbReference type="SMR" id="Q5CT20"/>
    <dbReference type="STRING" id="353152.Q5CT20"/>
    <dbReference type="GeneID" id="3371420"/>
    <dbReference type="KEGG" id="cpv:cgd1_370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_370"/>
    <dbReference type="InParanoid" id="Q5CT20"/>
    <dbReference type="OrthoDB" id="3626597at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004181">
        <property type="term" value="F:metallocarboxypeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000834">
        <property type="entry name" value="Peptidase_M14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705">
        <property type="entry name" value="PROTEASE FAMILY M14 CARBOXYPEPTIDASE A,B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11705:SF143">
        <property type="entry name" value="SLL0236 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00246">
        <property type="entry name" value="Peptidase_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00765">
        <property type="entry name" value="CRBOXYPTASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00631">
        <property type="entry name" value="Zn_pept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52035">
        <property type="entry name" value="PEPTIDASE_M14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0121">Carboxypeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="697"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M14" evidence="9">
        <location>
            <begin position="81"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="7">
        <location>
            <position position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="747" mass="85274" checksum="8CF02E65BEBD6D90" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT89</accession>
    <name>Q5CT89_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Myb domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd2_3980</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626580.1">
        <property type="nucleotide sequence ID" value="XM_626580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT89"/>
    <dbReference type="STRING" id="353152.Q5CT89"/>
    <dbReference type="GeneID" id="3373395"/>
    <dbReference type="KEGG" id="cpv:cgd2_3980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3980"/>
    <dbReference type="InParanoid" id="Q5CT89"/>
    <dbReference type="OMA" id="IDNHTER"/>
    <dbReference type="OrthoDB" id="342406at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000151">
        <property type="entry name" value="histone H2A deubiquitinase MYSM1 isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006447">
        <property type="entry name" value="Myb_dom_plants"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01557">
        <property type="entry name" value="myb_SHAQKYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44042">
        <property type="entry name" value="DUPLICATED HOMEODOMAIN-LIKE SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="SANT" evidence="12">
        <location>
            <begin position="54"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="13">
        <location>
            <begin position="57"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="11">
        <location>
            <begin position="57"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="398"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="400"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="413"/>
            <end position="445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK88637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="585" mass="64453" checksum="D5052636486459C7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT96</accession>
    <name>Q5CT96_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser/Thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626573.1">
        <property type="nucleotide sequence ID" value="XM_626573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT96"/>
    <dbReference type="STRING" id="353152.Q5CT96"/>
    <dbReference type="GeneID" id="3373694"/>
    <dbReference type="KEGG" id="cpv:cgd2_3890"/>
    <dbReference type="InParanoid" id="Q5CT96"/>
    <dbReference type="OMA" id="GINIFFQ"/>
    <dbReference type="OrthoDB" id="541276at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="44"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="418" mass="49097" checksum="6F4F7AC5AD81D2FE" modified="2005-04-12" version="1" fragment="single">KHKTRQKLHYNSYNKISTNTMRKTKQSNQNQNIPENQYIPINNYKVIKILGKGAYGTVYQAIKKDNQSDTEMALNINENSSQNSQDKYKTKIKTKTTKNYYNNKKYYAIKAFDKDLSKKGIHPSILREIGILKELSNHHYFNQLFIQLEDVILENDRIFAIYEYGGISLLTFIEEKCSHYNYKNNQTHPHPHPILNLQFGINIFFQIINSIQFLHNLGIVHRDLKPENILINEDNLQIKIADFGLARSIRNHSYTNFTNDVVTIYYKSPELIIYSNMDNFNNKNHFIPEISLPFSIDSWSIGVIALELFIIICNQYNNSQNQNYSIYNTRNHLKNQKNDSIIWSPFFFEGNELSVLDSIQKILHPSQKINNLKNLLLPLFQSYPQIFYLISELLELDPNKRCSCIQAFQILENFKSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTC2</accession>
    <name>Q5CTC2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_3600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626547.1">
        <property type="nucleotide sequence ID" value="XM_626547.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373623"/>
    <dbReference type="KEGG" id="cpv:cgd2_3600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3600"/>
    <dbReference type="InParanoid" id="Q5CTC2"/>
    <dbReference type="OMA" id="CVENEAF"/>
    <dbReference type="OrthoDB" id="339561at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1467" mass="168885" checksum="7123809221071A08" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTD5</accession>
    <name>Q5CTD5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626534.1">
        <property type="nucleotide sequence ID" value="XM_626534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTD5"/>
    <dbReference type="GeneID" id="3373757"/>
    <dbReference type="KEGG" id="cpv:cgd2_3470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3470"/>
    <dbReference type="InParanoid" id="Q5CTD5"/>
    <dbReference type="OrthoDB" id="343030at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="353" mass="41849" checksum="D30F58A45614A5AB" modified="2005-04-12" version="1">MHAKLKSSQIWLFALLIVVIICEIRCKVNFLDFFENFVQELRKDILITDQCTTRKEEELKCYWIILESELIHLLKAAKSGSNGIFGFNGRTKNIIFLRKLIDLINKNTKSKIRERFIAYQSHPYLNSTIISNYDIKWYNQYELEDIERIVNQLSKINLGDYGIMKFGNENSKFENNSKNLTIKLVILSIFYKQYSIDQLAYRKIAENTDTVNNYIQHLSKSVSTEIKLIDEDIENLMKNLEVSMGNKKKSLSRKIEFILENIKSKLTSYIEKINNSFDNIRKKLYSRILEYYLLVIILAKLFFIFSRKMLSMILLLNHILIYILDNFEDYTFMLISLQFGFEMVSTFIQEILH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTE9</accession>
    <name>Q5CTE9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RecQ mediated genome instability protein 1 OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_3300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626520.1">
        <property type="nucleotide sequence ID" value="XM_626520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTE9"/>
    <dbReference type="STRING" id="353152.Q5CTE9"/>
    <dbReference type="GeneID" id="3373762"/>
    <dbReference type="KEGG" id="cpv:cgd2_3300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3300"/>
    <dbReference type="InParanoid" id="Q5CTE9"/>
    <dbReference type="OMA" id="NSIIESW"/>
    <dbReference type="OrthoDB" id="434939at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681">
        <property type="entry name" value="SURVIVAL OF MOTOR NEURON-RELATED-SPLICING FACTOR 30-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13681:SF24">
        <property type="entry name" value="TUDOR DOMAIN-CONTAINING PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="5">
        <location>
            <begin position="200"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="385"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="398"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="475"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="492"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="570" mass="62971" checksum="EE7DB4009A439AF0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTF4</accession>
    <name>Q5CTF4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">3x TPR domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_3250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626515.1">
        <property type="nucleotide sequence ID" value="XM_626515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTF4"/>
    <dbReference type="STRING" id="353152.Q5CTF4"/>
    <dbReference type="GeneID" id="3373765"/>
    <dbReference type="KEGG" id="cpv:cgd2_3250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3250"/>
    <dbReference type="InParanoid" id="Q5CTF4"/>
    <dbReference type="OMA" id="WEDAIQC"/>
    <dbReference type="OrthoDB" id="1936594at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044244">
        <property type="entry name" value="TTC27/Emw1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16193:SF0">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="664"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="698"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="960" mass="111454" checksum="B21133E68C844AE1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTK6</accession>
    <name>Q5CTK6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626463.1">
        <property type="nucleotide sequence ID" value="XM_626463.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373639"/>
    <dbReference type="KEGG" id="cpv:cgd2_2610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2610"/>
    <dbReference type="InParanoid" id="Q5CTK6"/>
    <dbReference type="OMA" id="ECETEIF"/>
    <dbReference type="OrthoDB" id="337382at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2612" mass="296194" checksum="400A8D0B9F6FFE3F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTL0</accession>
    <name>Q5CTL0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_2570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626459.1">
        <property type="nucleotide sequence ID" value="XM_626459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTL0"/>
    <dbReference type="GeneID" id="3373643"/>
    <dbReference type="KEGG" id="cpv:cgd2_2570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2570"/>
    <dbReference type="InParanoid" id="Q5CTL0"/>
    <dbReference type="OrthoDB" id="342818at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254230" evidence="1">
        <location>
            <begin position="23"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="180" mass="20737" checksum="B7441DFB565A8300" modified="2005-04-12" version="1">MSKRASLFIFIFFVLFDIFATSQHEVSPKLAVSRAEALSFENSEISLKELASRLKTLLSVEQIIYLVRKIIPEDFQLVAKSSEHDYFDVSESTLKETYENIIYQNLTKVPIYQLVHIPELLSNATHLRKIRNAISSPRPVRPRKQIKGRNPSNIPGASPYFVYERVIEIYNSDSDVQTDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTN0</accession>
    <name>Q5CTN0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MA3 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_2350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PDCD4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626439.1">
        <property type="nucleotide sequence ID" value="XM_626439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTN0"/>
    <dbReference type="STRING" id="353152.Q5CTN0"/>
    <dbReference type="GeneID" id="3373508"/>
    <dbReference type="KEGG" id="cpv:cgd2_2350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2350"/>
    <dbReference type="InParanoid" id="Q5CTN0"/>
    <dbReference type="OMA" id="CHAIDSG"/>
    <dbReference type="OrthoDB" id="414546at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039778">
        <property type="entry name" value="PDCD4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12626">
        <property type="entry name" value="PROGRAMMED CELL DEATH 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12626:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="MI" evidence="6">
        <location>
            <begin position="66"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="MI" evidence="6">
        <location>
            <begin position="247"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="571" mass="65023" checksum="A6AEF52A3C5EDB26" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTP6</accession>
    <name>Q5CTP6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626423.1">
        <property type="nucleotide sequence ID" value="XM_626423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTP6"/>
    <dbReference type="GeneID" id="3373520"/>
    <dbReference type="KEGG" id="cpv:cgd2_2180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2180"/>
    <dbReference type="InParanoid" id="Q5CTP6"/>
    <dbReference type="OrthoDB" id="343232at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="116" mass="12971" checksum="6B53DCF60AE51563" modified="2005-04-12" version="1">MGNEQSKTNYSKEINTEVENNKSKIKSNISIGLKNSVKKNSSIRKTSSSELDECSDNESFSLIVKHKTQNSNMKKGFINSTSNSKNGNNDLDWDTIIHIIDTDVIEGMVIIEDSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTR1</accession>
    <name>Q5CTR1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_2010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626408.1">
        <property type="nucleotide sequence ID" value="XM_626408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTR1"/>
    <dbReference type="GeneID" id="3373532"/>
    <dbReference type="KEGG" id="cpv:cgd2_2010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2010"/>
    <dbReference type="InParanoid" id="Q5CTR1"/>
    <dbReference type="OMA" id="LAGFKWE"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="64"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="2">
        <location>
            <begin position="231"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="267" mass="30052" checksum="35A30C5D475924A6" modified="2005-04-12" version="1">MYGNRDKEIGVFQEKIEHSGEIVDATLAEFNVKYQTLFFIATLVLSIAGFFSAIYSLFGLRITNFVNSCLQLIVGVLLLLLDIPGQPRWSAKFRSDIRRQARILSKLTGKSLSLLFLSCLCSTTLRTNNRGPMIISMFSKTKSKSPGLFLLTFLVCLLTSSVAVLGLLISFEKGIRLNRIKKSVISSYTSVGACNTIEIYRSYALSDPLFGMLGDEFNRLISDRTDNNYQFSQDELSIIFNALDDNQKGSINEREFVEFFSSRFTLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTV4</accession>
    <name>Q5CTV4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">J domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626365.1">
        <property type="nucleotide sequence ID" value="XM_626365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTV4"/>
    <dbReference type="GeneID" id="3373729"/>
    <dbReference type="KEGG" id="cpv:cgd2_1420"/>
    <dbReference type="InParanoid" id="Q5CTV4"/>
    <dbReference type="OMA" id="CNERSQV"/>
    <dbReference type="OrthoDB" id="342454at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="268" mass="31198" checksum="3EF486D9774ACE60" modified="2005-04-12" version="1">MDKGEPYGCRSKSVIKPEFKNFLYKPSIQKVNAIGNNVYICNFHGWKGGRNSQKCPECVEIEKKIMERLSHTKFKNVAGIDYIEGTNTLEGMRIWLRCNMGHKLIYAMKDISRGCRVCSSEKYLSPKYRNNAIKLDIKKEEEYRRKQGELIAEAKQIFEMKSNTNSGNQNIDLEVQECIDNHPNISYETAYALTYILKFGYEPYKLFQVPNIITSENKVSILKRINTYFRTQARLIHPDKSDHPRSADAFHILSNAYNQIKNYLENKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTW9</accession>
    <name>Q5CTW9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM4</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_1250</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="11">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626350.1">
        <property type="nucleotide sequence ID" value="XM_626350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTW9"/>
    <dbReference type="FunCoup" id="Q5CTW9">
        <property type="interactions" value="421"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTW9"/>
    <dbReference type="GeneID" id="3373682"/>
    <dbReference type="KEGG" id="cpv:cgd2_1250"/>
    <dbReference type="InParanoid" id="Q5CTW9"/>
    <dbReference type="OMA" id="GRQNECK"/>
    <dbReference type="OrthoDB" id="10251574at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000217">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008047">
        <property type="entry name" value="MCM_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF66">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01660">
        <property type="entry name" value="MCMPROTEIN4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="12">
        <location>
            <begin position="450"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="896" mass="99541" checksum="626210B55497B40E" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU37</accession>
    <name>Q5CU37_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative amino acid transporter, 11 transmembrane domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_4350</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626977.1">
        <property type="nucleotide sequence ID" value="XM_626977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU37"/>
    <dbReference type="STRING" id="353152.Q5CU37"/>
    <dbReference type="GeneID" id="3374053"/>
    <dbReference type="KEGG" id="cpv:cgd3_4350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4350"/>
    <dbReference type="InParanoid" id="Q5CU37"/>
    <dbReference type="OMA" id="FMIEIAD"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="158"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="463"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="497"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="45"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="539" mass="60467" checksum="FFB20A0318317026" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU91</accession>
    <name>Q5CU91_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small protein with possible EF hand domains, calmodulin like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_3760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626923.1">
        <property type="nucleotide sequence ID" value="XM_626923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU91"/>
    <dbReference type="STRING" id="353152.Q5CU91"/>
    <dbReference type="GeneID" id="3373932"/>
    <dbReference type="KEGG" id="cpv:cgd3_3760"/>
    <dbReference type="InParanoid" id="Q5CU91"/>
    <dbReference type="OMA" id="MPANSFV"/>
    <dbReference type="OrthoDB" id="429467at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050403">
        <property type="entry name" value="Myosin_RLC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23049">
        <property type="entry name" value="MYOSIN REGULATORY LIGHT CHAIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="68"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="143" mass="16025" checksum="65B4BC61EE6C2B53" modified="2005-04-12" version="1" fragment="single">ACILFRVLGQTITDRDLKTALLEGWPGLDIQSDETKDKGFKKIDTSSLAPIEFDAFIKIFRAKYKIPFDEDTIIEAFQVFDPENTGLMPANSFVKLMTTTGEPVPANDVEDLLLLANVDKDGKFDYTQLAKRLVEGPKNVRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUA5</accession>
    <name>Q5CUA5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Mannosyltransferase</fullName>
            <ecNumber evidence="8">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd3_3590</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the glycosyltransferase 22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626909.1">
        <property type="nucleotide sequence ID" value="XM_626909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUA5"/>
    <dbReference type="FunCoup" id="Q5CUA5">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUA5"/>
    <dbReference type="GeneID" id="3373938"/>
    <dbReference type="KEGG" id="cpv:cgd3_3590"/>
    <dbReference type="InParanoid" id="Q5CUA5"/>
    <dbReference type="OMA" id="CYDTPLY"/>
    <dbReference type="OrthoDB" id="416834at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000026">
        <property type="term" value="F:alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005599">
        <property type="entry name" value="GPI_mannosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760">
        <property type="entry name" value="GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22760:SF4">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03901">
        <property type="entry name" value="Glyco_transf_22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="2 8 9" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="63"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="173"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="281"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="333"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="391"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="445"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="637" mass="75649" checksum="3AC29DAD05816F30" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUG1</accession>
    <name>Q5CUG1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">KNTC1 third ARM-repeats domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626853.1">
        <property type="nucleotide sequence ID" value="XM_626853.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUG1"/>
    <dbReference type="GeneID" id="3374098"/>
    <dbReference type="KEGG" id="cpv:cgd3_2960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2960"/>
    <dbReference type="InParanoid" id="Q5CUG1"/>
    <dbReference type="OrthoDB" id="343783at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005828">
        <property type="term" value="C:kinetochore microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1903394">
        <property type="term" value="P:protein localization to kinetochore involved in kinetochore assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055405">
        <property type="entry name" value="ARM_KNTC1_3rd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052802">
        <property type="entry name" value="KNTC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15688:SF1">
        <property type="entry name" value="KINETOCHORE-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24515">
        <property type="entry name" value="ARM_KNTC1_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="KNTC1 third ARM-repeats" evidence="1">
        <location>
            <begin position="1445"/>
            <end position="1644"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF24515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2691" mass="314302" checksum="4E4EF8B7779ADADF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUH7</accession>
    <name>Q5CUH7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cullin domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_2790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626837.1">
        <property type="nucleotide sequence ID" value="XM_626837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUH7"/>
    <dbReference type="STRING" id="353152.Q5CUH7"/>
    <dbReference type="GeneID" id="3373955"/>
    <dbReference type="KEGG" id="cpv:cgd3_2790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2790"/>
    <dbReference type="InParanoid" id="Q5CUH7"/>
    <dbReference type="OMA" id="NYQEQTW"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="4">
        <location>
            <begin position="447"/>
            <end position="672"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="851" mass="100735" checksum="A43BEEE4BF4ADFF0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUL6</accession>
    <name>Q5CUL6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DPH-type MB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_2340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626798.1">
        <property type="nucleotide sequence ID" value="XM_626798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUL6"/>
    <dbReference type="FunCoup" id="Q5CUL6">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="GeneID" id="3373780"/>
    <dbReference type="KEGG" id="cpv:cgd3_2340"/>
    <dbReference type="InParanoid" id="Q5CUL6"/>
    <dbReference type="OMA" id="YIDELEW"/>
    <dbReference type="OrthoDB" id="66964at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DPH-type MB" evidence="3">
        <location>
            <begin position="23"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="102" mass="11766" checksum="B82B54050F4996AF" modified="2005-04-12" version="1" fragment="single">IKQFRFALIANSNLSMNDKNGFIWKVIYIDELEWLDIYSGTLSYNCSCGDIFWTTLPYLEEIVNSEAKGNDSSVVLQCESCSLKIKVIFNKESLNEIKKRIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUV9</accession>
    <name>Q5CUV9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">60S ribosomal protein L12</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_1300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626705.1">
        <property type="nucleotide sequence ID" value="XM_626705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUV9"/>
    <dbReference type="FunCoup" id="Q5CUV9">
        <property type="interactions" value="318"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUV9"/>
    <dbReference type="GeneID" id="3373837"/>
    <dbReference type="KEGG" id="cpv:cgd3_1300"/>
    <dbReference type="InParanoid" id="Q5CUV9"/>
    <dbReference type="OMA" id="QPPHDVI"/>
    <dbReference type="OrthoDB" id="1478556at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.250:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1550.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.250">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1550.10">
        <property type="entry name" value="Ribosomal protein L11/L12, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00736">
        <property type="entry name" value="Ribosomal_uL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000911">
        <property type="entry name" value="Ribosomal_uL11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020783">
        <property type="entry name" value="Ribosomal_uL11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036769">
        <property type="entry name" value="Ribosomal_uL11_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020784">
        <property type="entry name" value="Ribosomal_uL11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036796">
        <property type="entry name" value="Ribosomal_uL11_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11661:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00298">
        <property type="entry name" value="Ribosomal_L11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03946">
        <property type="entry name" value="Ribosomal_L11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00649">
        <property type="entry name" value="RL11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54747">
        <property type="entry name" value="Ribosomal L11/L12e N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46906">
        <property type="entry name" value="Ribosomal protein L11, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL11 N-terminal" evidence="6">
        <location>
            <begin position="18"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL11 C-terminal" evidence="5">
        <location>
            <begin position="78"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00298"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="169" mass="18056" checksum="4D3CE495A9E90781" modified="2005-04-12" version="1" fragment="single">ITMPPAGKADPSEVKYLYIRQLGGEVGATSVLAPKLGPLGMSPKKVGDDIAKGTAAWKGMKVCVKLTVQNRQAKIDVVPTATCLLIKELKEPIRDRKKVKNIKHSGNLSMNQVISVARAMKFKSRAKAFSGTVKEILGTCNAIGCTVDGQKPVDLQKMIDAGEIEVPTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUW1</accession>
    <name>Q5CUW1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626703.1">
        <property type="nucleotide sequence ID" value="XM_626703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUW1"/>
    <dbReference type="GeneID" id="3373989"/>
    <dbReference type="KEGG" id="cpv:cgd3_1280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1280"/>
    <dbReference type="InParanoid" id="Q5CUW1"/>
    <dbReference type="OMA" id="DRVQRIN"/>
    <dbReference type="OrthoDB" id="343795at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="557"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="682"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="276"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="559"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="712" mass="82124" checksum="00C5D77DFE9DB449" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV61</accession>
    <name>Q5CV61_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_5300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627408.1">
        <property type="nucleotide sequence ID" value="XM_627408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV61"/>
    <dbReference type="GeneID" id="3374210"/>
    <dbReference type="KEGG" id="cpv:cgd8_5300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5300"/>
    <dbReference type="InParanoid" id="Q5CV61"/>
    <dbReference type="OMA" id="KSRTHDI"/>
    <dbReference type="OrthoDB" id="343898at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254440" evidence="2">
        <location>
            <begin position="26"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="114"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="599"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="297"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="488"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="717"/>
            <end position="730"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="816" mass="90316" checksum="B08C636F87BF58F9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVA1</accession>
    <name>Q5CVA1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Large protein with 2 MYB domains plus low complexity GA repeat and Q repeat at the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_4840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627368.1">
        <property type="nucleotide sequence ID" value="XM_627368.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVA1"/>
    <dbReference type="GeneID" id="3374373"/>
    <dbReference type="KEGG" id="cpv:cgd8_4840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4840"/>
    <dbReference type="InParanoid" id="Q5CVA1"/>
    <dbReference type="OMA" id="FGVDLMM"/>
    <dbReference type="OrthoDB" id="10258692at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47340">
        <property type="entry name" value="DUPLICATED HOMEODOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47340:SF1">
        <property type="entry name" value="DUPLICATED HOMEODOMAIN-LIKE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SANT" evidence="3">
        <location>
            <begin position="1066"/>
            <end position="1117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="853"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="923"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1472"/>
            <end position="1516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1527"/>
            <end position="1546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1949"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2016"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2383"/>
            <end position="2409"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="2238"/>
            <end position="2312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="862"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="931"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1494"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1527"/>
            <end position="1543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1949"/>
            <end position="1964"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1965"/>
            <end position="1975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2021"/>
            <end position="2039"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2383"/>
            <end position="2402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2409" mass="266381" checksum="E864E87CEE97F759" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVC7</accession>
    <name>Q5CVC7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627342.1">
        <property type="nucleotide sequence ID" value="XM_627342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVC7"/>
    <dbReference type="GeneID" id="3374441"/>
    <dbReference type="KEGG" id="cpv:cgd8_4570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4570"/>
    <dbReference type="InParanoid" id="Q5CVC7"/>
    <dbReference type="OMA" id="HDFTERF"/>
    <dbReference type="OrthoDB" id="419711at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242:SF1">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12242">
        <property type="entry name" value="OS02G0130600 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="315"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="383"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="424"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="474" mass="55292" checksum="EA840DC9914DC85F" modified="2005-04-12" version="1">MVNVSENIKRGWKLILHRFIWEYKLSRAINRITFTFDEFEQTNHFNCSWIIPQWFLIYLRLSVFLYLLIMLGLDVSNYYKLGYAMYWGVYVTNWTYAITIIYYFFATTSTIYSYANNSFGRKKYIKSLKMTNSPSIGGRIHLKLDDDIIGHQNVNSRPRGSILNILDRKFEHINPSKHNEQVVVSDHTTNGYSSSPKNAQLNEIQMVDLNLENNNSNKNKEASYGHASIVSISTAFESPENLNKNAIKNNTERNNEYIIPRKTRNIFVRYYNHLKSHMFIIKYCKETDRPHFADEINQRMDNTTTNINLPLLIRLMWVFHAIALPASFIVSIVYWSMSIISPVGVDGFSFLTFNKHGLTAILLSLDTYFTTIPFFISQAFYSFLYCLIYLIFTIVYFILKLPNPQSQDDLGFIYSAINFADPAVSIPCSIGIFFLLFLTSNIIWFFVGFSRNHIIDPLPSDDISSKEFRVNYYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVG9</accession>
    <name>Q5CVG9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627300.1">
        <property type="nucleotide sequence ID" value="XM_627300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVG9"/>
    <dbReference type="GeneID" id="3374186"/>
    <dbReference type="KEGG" id="cpv:cgd8_4090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4090"/>
    <dbReference type="InParanoid" id="Q5CVG9"/>
    <dbReference type="OMA" id="NIDFCKL"/>
    <dbReference type="OrthoDB" id="342466at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="278" mass="31623" checksum="22027DCE4684C9D4" modified="2005-04-12" version="1">MTESNRYKRLRVFTAAFSMIVAGIWWILALFSRSYHYLIISFPIGNYLSMDISLWNIWASSDCNPTMFNGRLNFDFCRWVISNIDGNSIGEVMRFLCLRGYGLTSEESNCTTFSNLYTASAAMISSIIIIVVLLISAPTWLLVLYFRGSKKKIRPIVLTQLLLASAVSLLSLFLYTSIGGFQAEFNGFSHSIKTNRLSSLFFNSSTLNSGFYISIAASALTIFLIPWISYIIKNIESEEFDSTTYVSALKQTYYNYRLEDEIAETERLIHKLRTGPII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVL1</accession>
    <name>Q5CVL1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA 3'-Terminal Phosphate Cyclase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_3660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627258.1">
        <property type="nucleotide sequence ID" value="XM_627258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVL1"/>
    <dbReference type="FunCoup" id="Q5CVL1">
        <property type="interactions" value="258"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVL1"/>
    <dbReference type="GeneID" id="3374607"/>
    <dbReference type="KEGG" id="cpv:cgd8_3660"/>
    <dbReference type="InParanoid" id="Q5CVL1"/>
    <dbReference type="OMA" id="FFMNNLK"/>
    <dbReference type="OrthoDB" id="1911237at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00875">
        <property type="entry name" value="RNA_Cyclase_Class_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.65.10.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.20">
        <property type="entry name" value="RNA 3'-terminal phosphate cyclase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013791">
        <property type="entry name" value="RNA3'-term_phos_cycl_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023797">
        <property type="entry name" value="RNA3'_phos_cyclase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037136">
        <property type="entry name" value="RNA3'_phos_cyclase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000228">
        <property type="entry name" value="RNA3'_term_phos_cyc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016443">
        <property type="entry name" value="RNA3'_term_phos_cyc_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013792">
        <property type="entry name" value="RNA3'P_cycl/enolpyr_Trfase_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036553">
        <property type="entry name" value="RPTC_insert"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03400">
        <property type="entry name" value="18S_RNA_Rcl1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096">
        <property type="entry name" value="RNA 3' TERMINAL PHOSPHATE CYCLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11096:SF1">
        <property type="entry name" value="RNA 3'-TERMINAL PHOSPHATE CYCLASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01137">
        <property type="entry name" value="RTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05189">
        <property type="entry name" value="RTC_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55205">
        <property type="entry name" value="EPT/RTPC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase" evidence="5">
        <location>
            <begin position="29"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="RNA 3'-terminal phosphate cyclase insert" evidence="6">
        <location>
            <begin position="214"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="464" mass="51881" checksum="2B5566B98AD7A10F" modified="2005-04-12" version="1" fragment="single">IKLSVEVCISLIEFLQVKQFFSIFFDMLIFKGGNFLRQRLALSTITGKPIIIKEIRADDTLNPGLNDSETSLLHLLDYVTDGSKIKINDTGTTLNYTPGIITGGGTSDKPLIHECHPSRSLSYYIEFLLMFAQFGRDPLCIKLIGITDNSSTDHSSDLIRMVTIPLIKKMIPQVGEISLSIIKRSVSQNSPGQVQLNIPTIKKIEPILMDGPIGRIKRIRGISWYTGSASAQIAIKMISKARGILNKFIPDVWIYFDKPKKDSLQNDEEITGFGMTLVAESIKGITIGSNCSFISSSIDVQKMLNIPMESFEEEQVFNSDNINEYQIPDLSSDLSANGEYSNESRNETSSSIQEIQNNEEFKSLTEWEKIGWLTASRLLLEIDSQSNVDTSHQIYPLLFMSLSQDTATSKLKLSKLAPMTIQFMRDLKTFTNIEFTIKEDTENGLFIILSCTGIGFSNFARKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVL2</accession>
    <name>Q5CVL2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted DM-LD37668p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_3650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627257.1">
        <property type="nucleotide sequence ID" value="XM_627257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVL2"/>
    <dbReference type="STRING" id="353152.Q5CVL2"/>
    <dbReference type="GeneID" id="3374623"/>
    <dbReference type="KEGG" id="cpv:cgd8_3650"/>
    <dbReference type="InParanoid" id="Q5CVL2"/>
    <dbReference type="OMA" id="REYNNLG"/>
    <dbReference type="OrthoDB" id="10250284at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010378">
        <property type="entry name" value="TRAPPC13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13134:SF3">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="308" mass="35539" checksum="C63CAFF2B7B454D6" modified="2005-04-12" version="1" fragment="single">VELVGTKKRHILYNNEDNYSDIDIGDSLDIVVKERVDEVGLYSLTCQLFFTSNEARLTQKKSYKFAVLSPFNISHRLYNLDEDTMDKKTIFVEVSLENVSHQSITLSSMKLEPINIKKLPELIFELEDVNLKNKHNEPLYIQPRCKYNKIFKFTSCSREYNNLGKSSREVLELKLRIGWVSVSYGDGWLDSYKIGLPILCDQNKLNKEKNAIILKAELPSVNNRQEEFKVFLYVTNNLSIDQKGMSIRLDFDQLLPIIILGNDRLYLEELKAGETVTLELDCQALVSGVYNLNGIYVFDELEDKKVSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVV0</accession>
    <name>Q5CVV0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_2690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627169.1">
        <property type="nucleotide sequence ID" value="XM_627169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVV0"/>
    <dbReference type="GeneID" id="3374384"/>
    <dbReference type="KEGG" id="cpv:cgd8_2690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2690"/>
    <dbReference type="InParanoid" id="Q5CVV0"/>
    <dbReference type="OMA" id="YCNINED"/>
    <dbReference type="OrthoDB" id="18412at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="2">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="178" mass="20525" checksum="8312E02BEC1B9D13" modified="2005-04-12" version="1">MSKMEGSETGSLINDKICVICGVNIGKYKFKCCLRKFCSLECFQIHSREECSLKSNQISDSLQSDQNFEEICNEMKLESAIEETEQFDLTEKEKEALNSNERLSSLLRNNPRLVEMIKFIEHSENKTEALALIMDEDSKDKDKLFAEFTELVAESLGEEFKTYKNTYDSIVSDISLRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVW1</accession>
    <name>Q5CVW1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">glycine hydroxymethyltransferase</fullName>
            <ecNumber evidence="4">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_2580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627158.1">
        <property type="nucleotide sequence ID" value="XM_627158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVW1"/>
    <dbReference type="STRING" id="353152.Q5CVW1"/>
    <dbReference type="GeneID" id="3374352"/>
    <dbReference type="KEGG" id="cpv:cgd8_2580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2580"/>
    <dbReference type="InParanoid" id="Q5CVW1"/>
    <dbReference type="OMA" id="QICAFAV"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="6">
        <location>
            <begin position="6"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="438" mass="49367" checksum="19F08E3E0EE08756" modified="2005-04-12" version="1">MNTTIESDQELFNIINKEKDFQNSHLNLHPKENVMINAARKVLGSILTNKYSEGFPGTRYYGGTHVIDKIETLCASRLKQFLKLDKKSNDEWLFNIQCYSGSHAELAICMGLLNKGDRILRIRGDSDTVLENYYQVEYYNLDKKGRGFDIVDLREKCKILKPKLLLVPSDVLTLFIDYRLLSEICNEFKIFLVADISEIALLISFDRYGREDNNPYRYCDIIYSNTQSSLGGPKGGFLMLNNSKNPGLFQKVNSAVFPGLQGGPHNHQIGSFAVQIQGMLTSRTSEFVAAALDNSAVLAQTMLDSGIPLLGDGTDTHLVSVDCERLGVPCELISKILTECKIRHTYRKFGENRSSLMFGTLVYTFREGSVSQMTILGNLISDCINVGVEIFNKVGKLDIPIEARENIFHEEITKSNKLKLIFDRVSGIISELETIYFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW07</accession>
    <name>Q5CW07_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_2080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627112.1">
        <property type="nucleotide sequence ID" value="XM_627112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW07"/>
    <dbReference type="STRING" id="353152.Q5CW07"/>
    <dbReference type="GeneID" id="3374499"/>
    <dbReference type="KEGG" id="cpv:cgd8_2080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2080"/>
    <dbReference type="InParanoid" id="Q5CW07"/>
    <dbReference type="OMA" id="HVVYPPY"/>
    <dbReference type="OrthoDB" id="344370at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="37"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="429"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="445"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="608" mass="66823" checksum="ED4E12CA1291DB14" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW51</accession>
    <name>Q5CW51_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sacsin like HSP90 chaperone domain, likely plant origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_1610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627068.1">
        <property type="nucleotide sequence ID" value="XM_627068.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW51"/>
    <dbReference type="GeneID" id="3374480"/>
    <dbReference type="KEGG" id="cpv:cgd8_1610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1610"/>
    <dbReference type="InParanoid" id="Q5CW51"/>
    <dbReference type="OMA" id="NIKCCER"/>
    <dbReference type="OrthoDB" id="426371at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052957">
        <property type="entry name" value="Auxin_embryo_med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024975">
        <property type="entry name" value="NOV_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387:SF0">
        <property type="entry name" value="PROTEIN NO VEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387">
        <property type="entry name" value="WU:FJ29H11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13020">
        <property type="entry name" value="NOV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sacsin/Nov" evidence="2">
        <location>
            <begin position="40"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Protein NO VEIN C-terminal" evidence="1">
        <location>
            <begin position="1987"/>
            <end position="2079"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2120" mass="246066" checksum="DB5F22FE7C1FD936" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW53</accession>
    <name>Q5CW53_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627066.1">
        <property type="nucleotide sequence ID" value="XM_627066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW53"/>
    <dbReference type="GeneID" id="3374478"/>
    <dbReference type="KEGG" id="cpv:cgd8_1590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1590"/>
    <dbReference type="InParanoid" id="Q5CW53"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="136" mass="14399" checksum="41339A754F0CAE8F" modified="2005-04-12" version="1">MPSYSLSSIKSSKFSFSPTPPFVPSFVPSPSILSPSISSPSSTPTSIPSPHSPTVSKSSSKSSISTSSLFSNSFSSKLVILSPLSSSKSSSPFFSLSFSFSLSLKISSSRNAFLTSNSLIIKYFNKQPGCLILEHD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWC8</accession>
    <name>Q5CWC8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626991.1">
        <property type="nucleotide sequence ID" value="XM_626991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWC8"/>
    <dbReference type="GeneID" id="3374526"/>
    <dbReference type="KEGG" id="cpv:cgd8_820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_820"/>
    <dbReference type="InParanoid" id="Q5CWC8"/>
    <dbReference type="OrthoDB" id="340197at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="370" mass="42376" checksum="B627599E29105FDE" modified="2005-04-12" version="1">MPIMKNRDAAFNYGCLMAELKEKMVLFRNRLNKGEEENQESFLKNNSQDESKIGRDSLISENELDFSLNIESSSKNTLVSDRIIQEDNTEIIVESGIENVDECRIGLSNDSKVFPYPICFVSKSLPTPPKDYNLRKTGIDLNKNRCFQGEDIECNRVSKKLMFLVEKEKNGGKEEWWKFRRENDNDDNYNLLQSQNLGEAIDTEKSFPNNNITNKLMQDDSKNRKANQGELSLTQNIISSQSDTNITAQKGEVIDKNRLLKNSQSIENIRGFEENIPSKMENLKHIQASSVSGLKKDNIASDNATIKNSSEYKINTNTQIICDVNKNGSISRKETQINPIFKKKSQIFQHRGNIITTRYYKMASQLRVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWE2</accession>
    <name>Q5CWE2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_5440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627862.1">
        <property type="nucleotide sequence ID" value="XM_627862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWE2"/>
    <dbReference type="GeneID" id="3375857"/>
    <dbReference type="KEGG" id="cpv:cgd6_5440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5440"/>
    <dbReference type="InParanoid" id="Q5CWE2"/>
    <dbReference type="OMA" id="ANHERCL"/>
    <dbReference type="OrthoDB" id="338064at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1277" mass="142266" checksum="C0575834F4A27BB5" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWG2</accession>
    <name>Q5CWG2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_5230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627842.1">
        <property type="nucleotide sequence ID" value="XM_627842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWG2"/>
    <dbReference type="GeneID" id="3375837"/>
    <dbReference type="KEGG" id="cpv:cgd6_5230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5230"/>
    <dbReference type="InParanoid" id="Q5CWG2"/>
    <dbReference type="OMA" id="EICNESN"/>
    <dbReference type="OrthoDB" id="341685at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="455" mass="53153" checksum="1FBD6CB0688FAC57" modified="2005-04-12" version="1">MEENTGNENYYSEFSNIYRGNDNFGMNFSNNIYDLVFVYSGPVKFSKNDINIDNNTNIENEAVNGPFFLISKGKKNDKDEYDYDDYISFSDFDRMILETNSNNKGNLTCFLDCNYSYMFLSDYTKGEEYCNNNNNNNNSNYENIRFNHHRISTMPEINNNNNNKDLLNINPNKTSYYKKRDLSVIILASCSSSIQDSQEIKLCSNNGIGLSIIYRRLFSYFIQSIIRYHFENIINKDNNQNFQLIPRITLKSLIEEISRNMFHYLTKNHLKNQIPILLASVGISTQDNILLNNDMNNINMMNYLNDGDYIIGNFDQKNKINSNISLSSSNNIMNFNKFPIKNLNMGNNKRIYNNNNNNNCYMYQRNIPNISISPNSNSNLIQEINQLRSELSYLKQTINSENIARNFNYNENNYNRINNGYKSYCPVQIFNSDTIFKKSVKPSSTITHHRTFTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWI0</accession>
    <name>Q5CWI0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosphoprotein phosphatase 2A 65K regulatory chain-like with HEAT repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_5000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627824.1">
        <property type="nucleotide sequence ID" value="XM_627824.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWI0"/>
    <dbReference type="GeneID" id="3375821"/>
    <dbReference type="KEGG" id="cpv:cgd6_5000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5000"/>
    <dbReference type="InParanoid" id="Q5CWI0"/>
    <dbReference type="OMA" id="HAWEENA"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="72"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="346"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="709"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1153"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="487"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="497"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="729"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="755"/>
            <end position="768"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1154"/>
            <end position="1167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1287" mass="144473" checksum="ED17BFB3A94025D7" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWK7</accession>
    <name>Q5CWK7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein RFT1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_4680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Intramembrane glycolipid transporter that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. RFT1 could mediate the translocation of the cytosolically oriented intermediate DolPP-GlcNAc2Man5, produced by ALG11, into the ER lumen where dolichol-linked oligosaccharides assembly continues. However, the intramembrane lipid transporter activity could not be confirmed in vitro.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Endoplasmic reticulum membrane</location>
            <topology evidence="1 9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the RFT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627797.1">
        <property type="nucleotide sequence ID" value="XM_627797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWK7"/>
    <dbReference type="STRING" id="353152.Q5CWK7"/>
    <dbReference type="GeneID" id="3375800"/>
    <dbReference type="KEGG" id="cpv:cgd6_4680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4680"/>
    <dbReference type="InParanoid" id="Q5CWK7"/>
    <dbReference type="OMA" id="WPGKLFG"/>
    <dbReference type="OrthoDB" id="341456at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034203">
        <property type="term" value="P:glycolipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007594">
        <property type="entry name" value="RFT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117">
        <property type="entry name" value="ENDOPLASMIC RETICULUM MULTISPAN TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13117:SF5">
        <property type="entry name" value="PROTEIN RFT1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04506">
        <property type="entry name" value="Rft-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="174"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="381"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="529"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="557" mass="62521" checksum="73EB208D2638549C" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWL4</accession>
    <name>Q5CWL4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PIG-H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_4600</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PIGH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627790.1">
        <property type="nucleotide sequence ID" value="XM_627790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWL4"/>
    <dbReference type="STRING" id="353152.Q5CWL4"/>
    <dbReference type="GeneID" id="3375795"/>
    <dbReference type="KEGG" id="cpv:cgd6_4600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4600"/>
    <dbReference type="InParanoid" id="Q5CWL4"/>
    <dbReference type="OMA" id="INEFYYS"/>
    <dbReference type="OrthoDB" id="6256716at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044215">
        <property type="entry name" value="PIG-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019328">
        <property type="entry name" value="PIGH-H_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15231:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10181">
        <property type="entry name" value="PIG-H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="51"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="75"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidylinositol N-acetylglucosaminyltransferase subunit H conserved" evidence="4">
        <location>
            <begin position="101"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="182" mass="21059" checksum="BE3762866686DD37" modified="2007-04-03" version="1">MKNPNGSNICNFEENAETTKIETNDFKDYQFQTTYYGNSVAKFNASKKRTYFPIVLVSGIAYIATQILNKGVFSLSTWLRVIPILMIFLIYYRKVRVRRQSILIFYGIGVQLETEYLFGRSCSFIETTKIISAIIYDKMTYMELSPCIGLIIKDEKSLVVPFSDFKIPTKKNIIIYNALKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWN9</accession>
    <name>Q5CWN9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoglycerate mutase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627765.1">
        <property type="nucleotide sequence ID" value="XM_627765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWN9"/>
    <dbReference type="GeneID" id="3375776"/>
    <dbReference type="KEGG" id="cpv:cgd6_4330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4330"/>
    <dbReference type="InParanoid" id="Q5CWN9"/>
    <dbReference type="OMA" id="SEACASW"/>
    <dbReference type="OrthoDB" id="496981at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050275">
        <property type="entry name" value="PGM_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100">
        <property type="entry name" value="BROAD-SPECIFICITY PHOSPHATASE YOR283W-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48100:SF44">
        <property type="entry name" value="PHOSPHATASE C1620.13-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="317" mass="36709" checksum="5E98A931E92E535C" modified="2007-04-03" version="1">MWFFIRHAESANNATNNNDSTDLGEKYSDERVPDPTLTELGRIQAEKTGLYLASESVKVWKQEREDQKSMNLASPTFKAIYCSPMQRSLETANEIQKILSIPVFVNPDLCEVGGVFKGRRHVYSPRESKEVCGGKKRSEIMEEFPNFQLDDRITEKGWWGKPQETFKEASERAQKVAELLWEISCEDLQKKGTEYQGNTNILISHGLFQDMIMKRLFMHRSPLPSLEESAIFPCENCAISQIVLYDHNIRQYEDTSHKDYSQNNPRRVCICIKWNSSHHLEDNERTTTRIYPNSRRNHQNTKNCSNSSSSSNTNNHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWW5</accession>
    <name>Q5CWW5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">EBNA1 binding protein 2 nucleolar protein p40</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_3450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627689.1">
        <property type="nucleotide sequence ID" value="XM_627689.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWW5"/>
    <dbReference type="FunCoup" id="Q5CWW5">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWW5"/>
    <dbReference type="GeneID" id="3375999"/>
    <dbReference type="KEGG" id="cpv:cgd6_3450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3450"/>
    <dbReference type="InParanoid" id="Q5CWW5"/>
    <dbReference type="OMA" id="LRNTPEM"/>
    <dbReference type="OrthoDB" id="443772at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034399">
        <property type="term" value="C:nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008610">
        <property type="entry name" value="Ebp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028">
        <property type="entry name" value="RRNA PROCESSING PROTEIN EBNA1-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13028:SF0">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN EBP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05890">
        <property type="entry name" value="Ebp2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="197"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="246" mass="28745" checksum="95CA3310A717A9D0" modified="2005-04-12" version="1">MSDSDSELETHVLEDNQGERISIDRGNKLVLDEEGIKRKISALDYGIQLGMKNVPFIETLAIVDKVGNEEKIDYKDNTKRESYFYSNTLRNVNKGCEILEKMNINWNRPDDMLAEMLKTDQHMKKIKMDLLKQEQKIKAVELKKQKYVEKKFTKKIQVEKKKLRKQETKKNLREIENWKKSDHKNSASIEESFDKYFSENSKKSDLNKNKKVSKHISKTNNFEITKNTNKPSKQGGGKGRKGGKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWZ2</accession>
    <name>Q5CWZ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Large low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_3160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Spindle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the INCENP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627662.1">
        <property type="nucleotide sequence ID" value="XM_627662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWZ2"/>
    <dbReference type="GeneID" id="3375690"/>
    <dbReference type="KEGG" id="cpv:cgd6_3160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3160"/>
    <dbReference type="InParanoid" id="Q5CWZ2"/>
    <dbReference type="OMA" id="NDEYMEH"/>
    <dbReference type="OrthoDB" id="339519at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005819">
        <property type="term" value="C:spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005635">
        <property type="entry name" value="Inner_centromere_prot_ARK-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03941">
        <property type="entry name" value="INCENP_ARK-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inner centromere protein ARK-binding" evidence="8">
        <location>
            <begin position="575"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="376"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="481"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="746"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="808"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="403"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="485"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="498"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF03941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="828" mass="91971" checksum="74ED60095FDBC309" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWZ8</accession>
    <name>Q5CWZ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Dual specificity phosphatase, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_3100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627656.1">
        <property type="nucleotide sequence ID" value="XM_627656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWZ8"/>
    <dbReference type="GeneID" id="3375685"/>
    <dbReference type="KEGG" id="cpv:cgd6_3100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3100"/>
    <dbReference type="InParanoid" id="Q5CWZ8"/>
    <dbReference type="OMA" id="CHPEITN"/>
    <dbReference type="OrthoDB" id="336906at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.250.10">
        <property type="entry name" value="Rhodanese-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036873">
        <property type="entry name" value="Rhodanese-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="377" mass="43086" checksum="34A88D92D5880690" modified="2005-04-12" version="1">MENHRAIEYNRLLNESRDVASLIKKGKELECKPISNKKLFNICQLLLCKNLKEIEKNSASIIDNEPVVICDIRTKNQIIKSRTKINGSIECNSLDRVKRIFPESNRNQSSEIIGIKRKHVIIYDFEGRLTNTSDLEISQREVLEYLKKCIQSIKSIYLLKNGYSSFSLEFPYICCSIDAECISSIKSIKNIPQNLKSKIIASIEYPLVISWGETYKIYLGNVFQSVHPQILKSLGIKTIMDFTPNKIKSASNNEVRIIHVNNSESKIPIEDEYLIYSNLPIEETIKSFKELEESNPDPKDIFPIMIVGTRVTNETVSIASVIVSYLRKMQITATLIFTLNQIGLDNNIISPTENEDIFKLLHPSNSQIAQMISFNFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX27</accession>
    <name>Q5CX27_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627627.1">
        <property type="nucleotide sequence ID" value="XM_627627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX27"/>
    <dbReference type="GeneID" id="3376152"/>
    <dbReference type="KEGG" id="cpv:cgd6_2760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2760"/>
    <dbReference type="InParanoid" id="Q5CX27"/>
    <dbReference type="OrthoDB" id="344176at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="278"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="361" mass="41262" checksum="5DCD1E2179B01367" modified="2007-04-03" version="1">MDSRTWFEGVSDCSKKIIEALKSDNHLYGRDSNHFAKEGLSIFYSYDLCSSSCSVPTVVTESNTLSSETKDNRMLFSSVDEETLLLLQEALKYHYSGGEGTFINLGTPVNEINGLNSAHKIVHSPEITVPSDDKETKVNTETEEDIFEGVGSIFDHKEHKRTRTRSLERSLTPDLDEFIENVYDFKEEALHNTNVQSSIQSQVIQTRKDQNSAQRSFGLASRTKNRKRNIDYSLLSRKGPMSAPDKSFESLKLPQFEDSSSSYAECYLEVDGVSHYETHHEELESSSIRSQNKEMEDSSSARDKSKRNIDKYKQRRKDKSVHQEWKSIQKIMNKQNFRSLETFKSLISDNNGSIKNNFGQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX47</accession>
    <name>Q5CX47_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627607.1">
        <property type="nucleotide sequence ID" value="XM_627607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX47"/>
    <dbReference type="GeneID" id="3376137"/>
    <dbReference type="KEGG" id="cpv:cgd6_2530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2530"/>
    <dbReference type="InParanoid" id="Q5CX47"/>
    <dbReference type="OMA" id="RSNICKS"/>
    <dbReference type="OrthoDB" id="338968at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="211"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="285" mass="32683" checksum="F5186080E134123A" modified="2007-04-03" version="1">MQQIQSKLSIISKSINSKSLNSFEFNNNYNSQNPKFQIVEEQKSGNNSELEFLIDASKFYSLICPSLSSRLICKVANLTSEISQTKSYSDYFSGKICPKCFSVYLIGINCKLEVKPIKGIIRKRLKKKLLKLSKISGQNFQNYSFKNILISCKLCKFSFKKPYWEKKIKNTNRHEPLNDAQNNKNKVEDILNYSNFILSNADTSIQDQCRQNSNKSGNSQNGNPNTNKNHRFFNKTQKAGSMLQEKKNSYVDITNLTELNKDIKSEQSSQSTQGNSFYDILSMLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX84</accession>
    <name>Q5CX84_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_2100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627570.1">
        <property type="nucleotide sequence ID" value="XM_627570.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX84"/>
    <dbReference type="GeneID" id="3376078"/>
    <dbReference type="KEGG" id="cpv:cgd6_2100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2100"/>
    <dbReference type="InParanoid" id="Q5CX84"/>
    <dbReference type="OMA" id="NIPHAND"/>
    <dbReference type="OrthoDB" id="341241at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35478">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35478:SF1">
        <property type="entry name" value="ZINC FINGER FYVE DOMAIN-CONTAINING PROTEIN 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1645" mass="193459" checksum="CD0CFE68CCFFF381" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXL5</accession>
    <name>Q5CXL5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627439.1">
        <property type="nucleotide sequence ID" value="XM_627439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXL5"/>
    <dbReference type="FunCoup" id="Q5CXL5">
        <property type="interactions" value="400"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXL5"/>
    <dbReference type="GeneID" id="3375860"/>
    <dbReference type="KEGG" id="cpv:cgd6_570"/>
    <dbReference type="InParanoid" id="Q5CXL5"/>
    <dbReference type="OMA" id="MIQMQTR"/>
    <dbReference type="OrthoDB" id="407959at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00337">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.150.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.150.20">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01367">
        <property type="entry name" value="Ribosomal_uL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000218">
        <property type="entry name" value="Ribosomal_uL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036853">
        <property type="entry name" value="Ribosomal_uL14_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761">
        <property type="entry name" value="50S/60S RIBOSOMAL PROTEIN L14/L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11761:SF8">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00238">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01374">
        <property type="entry name" value="Ribosomal_L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50193">
        <property type="entry name" value="Ribosomal protein L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="146" mass="15564" checksum="B4A115395536C66B" modified="2005-04-12" version="1" fragment="single">YSLYLEKMKRGRGAAGGAKMRITLGLNVGALINCCDNSGGKNLYIIAVKGTGSCLNRLPSASIGDMVLATVKKGKPELRKKVWPAVIVRQRKAFRRPEGTFLYFEDNAGVIVNPKGEMKGSAITGPVGKECAELWPKVSAAAPSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXR1</accession>
    <name>Q5CXR1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_5260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628669.1">
        <property type="nucleotide sequence ID" value="XM_628667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXR1"/>
    <dbReference type="GeneID" id="3372098"/>
    <dbReference type="KEGG" id="cpv:cgd7_5260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5260"/>
    <dbReference type="InParanoid" id="Q5CXR1"/>
    <dbReference type="OMA" id="CEDCEDP"/>
    <dbReference type="OrthoDB" id="342367at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="450"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="507"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="450"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="460"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="555" mass="63474" checksum="EC391C74F4667B01" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY19</accession>
    <name>Q5CY19_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628561.1">
        <property type="nucleotide sequence ID" value="XM_628559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY19"/>
    <dbReference type="GeneID" id="3372243"/>
    <dbReference type="KEGG" id="cpv:cgd7_4040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4040"/>
    <dbReference type="InParanoid" id="Q5CY19"/>
    <dbReference type="OMA" id="NINIWKM"/>
    <dbReference type="OrthoDB" id="342755at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="106" mass="11784" checksum="46F927AC3EFB700B" modified="2005-04-12" version="1">MSIFENLIRKSTGLNSEKLVGSIWDEKGIRLPLISIFLSFLFPPIGCITFLIMSRAPKSSPKYKISIIALYFGSLLSVVYTFLIAMFLLTTTGPKRASYVHTGAAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY37</accession>
    <name>Q5CY37_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_3810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628543.1">
        <property type="nucleotide sequence ID" value="XM_628541.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372128"/>
    <dbReference type="KEGG" id="cpv:cgd7_3810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3810"/>
    <dbReference type="InParanoid" id="Q5CY37"/>
    <dbReference type="OMA" id="YSEICTI"/>
    <dbReference type="OrthoDB" id="338100at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254637" evidence="2">
        <location>
            <begin position="34"/>
            <end position="1715"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="655"/>
            <end position="682"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1715" mass="197643" checksum="929C1CD754913AD5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY50</accession>
    <name>Q5CY50_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Heat shock protein 90 (Hsp90), signal peptide plus ER retention motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_3670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628530.1">
        <property type="nucleotide sequence ID" value="XM_628528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY50"/>
    <dbReference type="SMR" id="Q5CY50"/>
    <dbReference type="FunCoup" id="Q5CY50">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY50"/>
    <dbReference type="GeneID" id="3372116"/>
    <dbReference type="KEGG" id="cpv:cgd7_3670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3670"/>
    <dbReference type="InParanoid" id="Q5CY50"/>
    <dbReference type="OMA" id="GIEQHQY"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000005">
        <property type="entry name" value="Heat shock protein 90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0143">Chaperone</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254640" evidence="7">
        <location>
            <begin position="21"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="8">
        <location>
            <begin position="109"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="749"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="754"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="116"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="120"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="182"/>
            <end position="183"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="202"/>
            <end position="207"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="428"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="787" mass="89193" checksum="5D4FDF2C7B31D1B8" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY51</accession>
    <name>Q5CY51_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_3660</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628529.1">
        <property type="nucleotide sequence ID" value="XM_628527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY51"/>
    <dbReference type="FunCoup" id="Q5CY51">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY51"/>
    <dbReference type="MEROPS" id="T01.972"/>
    <dbReference type="GeneID" id="3371940"/>
    <dbReference type="KEGG" id="cpv:cgd7_3660"/>
    <dbReference type="InParanoid" id="Q5CY51"/>
    <dbReference type="OMA" id="ATCIGKD"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008233">
        <property type="term" value="F:peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03750">
        <property type="entry name" value="proteasome_alpha_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000012">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="283" mass="31716" checksum="B9AB19C525DCD266" modified="2005-04-12" version="1" fragment="single">VHRTNCKLSLFIGNNHYGIINEPPFYSPHNKWQEFEYKIPQLDLFIAMDADYSFSLTTFSPSGKLVQIEYALNAVNSQGRPALGIKARNGVVIATEKKVASPLVEEHSIRKVELITSEIGCCFAGMPADFRVILKKSRKIAQVYYNTYREQIPVCELVREIATVMQEFTQSGGVRPFGISLLVAGFDSTRGPQLFQVDPSGAYFGWKASAIGKDMQNAKSFLEKRYNPDVEIEDALHTALLTLKECFEGAMNEDNIEVGIIGEDKNFTILSPQEIKDYLGEVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYW1</accession>
    <name>Q5CYW1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628269.1">
        <property type="nucleotide sequence ID" value="XM_628267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYW1"/>
    <dbReference type="GeneID" id="3372021"/>
    <dbReference type="KEGG" id="cpv:cgd7_800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_800"/>
    <dbReference type="InParanoid" id="Q5CYW1"/>
    <dbReference type="OMA" id="KEFAYFI"/>
    <dbReference type="OrthoDB" id="336262at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="274" mass="31628" checksum="DC6F0B0760A6CBC5" modified="2005-04-12" version="1">MSQEKWFVCKVKDFMSKRNTKINNLANIYSDDQNDLEEFFELPEKTGSYAIFMCYKLYSLFDPEDKGYISLKSIEQWAKMQYNSFCQDNNSSIDAKAFDMYKGKTQRICNSIETYKNNYIYYLKLKEEVENLEVDTQDIPITISEFITFVSPLFDNVEDSHAKKHKSLSNCSALHFSHIQETNLSLTNYFGTVTNSDPIGKYIPCTSSSSLYLEPKSKNVSRGKSRPFKNDILYISDSNLYHSSLWSPCINPASSSLHAMARELNKLQDSDDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYX0</accession>
    <name>Q5CYX0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Possible helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628260.1">
        <property type="nucleotide sequence ID" value="XM_628258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYX0"/>
    <dbReference type="STRING" id="353152.Q5CYX0"/>
    <dbReference type="GeneID" id="3372014"/>
    <dbReference type="KEGG" id="cpv:cgd7_710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_710"/>
    <dbReference type="InParanoid" id="Q5CYX0"/>
    <dbReference type="OMA" id="HNNNDKC"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="POLQ-like helical" evidence="5">
        <location>
            <begin position="866"/>
            <end position="1050"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1239" mass="142571" checksum="5AED15D1B6C6BDBD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ15</accession>
    <name>Q5CZ15_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_210</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 5">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628215.1">
        <property type="nucleotide sequence ID" value="XM_628213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ15"/>
    <dbReference type="STRING" id="353152.Q5CZ15"/>
    <dbReference type="GeneID" id="3372036"/>
    <dbReference type="KEGG" id="cpv:cgd7_210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_210"/>
    <dbReference type="InParanoid" id="Q5CZ15"/>
    <dbReference type="OMA" id="HANNEEQ"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="227"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="312" mass="33996" checksum="042BF258B3934C4A" modified="2005-04-12" version="1">MFKLIGFTLSTKGSKNNNKFEFSEFGLTLSHITLTEGTQVSVYVKFPTDQGYPQDDLIVATVTKSQPNACIHQQEFPTGSTLYCKGSGVVDCIANLPVQDCCEDGCCEANHSDDEESEISSLEGDESEKQVEDIEMKNFDSESESDSLSTASEKEPQKGGKKVIKTIEKVKAEDKKKASALTKDIKNVQNDIISPGFKKEFPNGLKYEVLSISKNVKSDIPQIALVGSKVNVKYEGRLAKTGKKFDSGNLSFTIGSGQVVPGFDQGVKGMIVTETRRVFIPSKLGYGARGCPPVIPKNADLVFEITLLSTKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ23</accession>
    <name>Q5CZ23_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative sortilin, SMART_VSP10 domain, possible signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628207.1">
        <property type="nucleotide sequence ID" value="XM_628205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ23"/>
    <dbReference type="FunCoup" id="Q5CZ23">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CZ23"/>
    <dbReference type="GeneID" id="3372032"/>
    <dbReference type="KEGG" id="cpv:cgd7_110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_110"/>
    <dbReference type="InParanoid" id="Q5CZ23"/>
    <dbReference type="OMA" id="FAPFYSV"/>
    <dbReference type="OrthoDB" id="443634at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006892">
        <property type="term" value="P:post-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031777">
        <property type="entry name" value="Sortilin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031778">
        <property type="entry name" value="Sortilin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006581">
        <property type="entry name" value="VPS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050310">
        <property type="entry name" value="VPS10-sortilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106">
        <property type="entry name" value="SORTILIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12106:SF27">
        <property type="entry name" value="SORTILIN-RELATED RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15902">
        <property type="entry name" value="Sortilin-Vps10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15901">
        <property type="entry name" value="Sortilin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00602">
        <property type="entry name" value="VPS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110296">
        <property type="entry name" value="Oligoxyloglucan reducing end-specific cellobiohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="VPS10" evidence="6">
        <location>
            <begin position="57"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="884"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="972"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="884"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="985"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="997"/>
            <end position="1006"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1006" mass="112308" checksum="A14DDF09315FAEAA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2011-01-11" modified="2025-06-18" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPN7</accession>
    <name>FEN1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Flap endonuclease 1</fullName>
            <shortName evidence="1">FEN-1</shortName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Flap structure-specific endonuclease 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="1" type="primary">FEN1</name>
        <name type="ORF">cgd7_2140</name>
    </gene>
    <organism>
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="1">Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
        <text evidence="1">Resides mostly in the nucleoli and relocalizes to the nucleoplasm upon DNA damage.</text>
    </comment>
    <comment type="PTM">
        <text evidence="1">Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388383.1">
        <property type="nucleotide sequence ID" value="XM_001388346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPN7"/>
    <dbReference type="SMR" id="A3FPN7"/>
    <dbReference type="FunCoup" id="A3FPN7">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPN7"/>
    <dbReference type="EnsemblProtists" id="EAZ51576">
        <property type="protein sequence ID" value="EAZ51576"/>
        <property type="gene ID" value="cgd7_2140"/>
    </dbReference>
    <dbReference type="GeneID" id="3371825"/>
    <dbReference type="KEGG" id="cpv:cgd7_2140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2140"/>
    <dbReference type="InParanoid" id="A3FPN7"/>
    <dbReference type="OMA" id="MGIPWVQ"/>
    <dbReference type="OrthoDB" id="1937206at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008409">
        <property type="term" value="F:5'-3' exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd09907">
        <property type="entry name" value="H3TH_FEN1-Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09867">
        <property type="entry name" value="PIN_FEN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.20:FF:000009">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000016">
        <property type="entry name" value="Flap endonuclease 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00614">
        <property type="entry name" value="Fen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002421">
        <property type="entry name" value="5-3_exonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023426">
        <property type="entry name" value="Flap_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019974">
        <property type="entry name" value="XPG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081:SF9">
        <property type="entry name" value="FLAP ENDONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11081">
        <property type="entry name" value="FLAP ENDONUCLEASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="SMART" id="SM00475">
        <property type="entry name" value="53EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00841">
        <property type="entry name" value="XPG_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00842">
        <property type="entry name" value="XPG_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0235">DNA replication</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0269">Exonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0460">Magnesium</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-0597">Phosphoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000403533" description="Flap endonuclease 1">
        <location>
            <begin position="1"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-domain">
        <location>
            <begin position="1"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="I-domain">
        <location>
            <begin position="124"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Interaction with PCNA" evidence="1">
        <location>
            <begin position="351"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="421"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="443"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="160"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="162"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="244"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>DNA</name>
            <dbReference type="ChEBI" id="CHEBI:16991"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="246"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <sequence length="490" mass="54994" checksum="B5534DEB5F50CCD4" modified="2007-04-03" version="1">MGIKGLTKFLADNAPKSIQQQGIGSLLGKRVAIDASMWIYQFLAAIREGSQWGNLTNSSGESTSHINGMLSRTTRLLEAGIKPVFVFDGAPPEMKKDELTKRDERREKALAELEKAQEIGDEELIKKQSVRTIHVTKKQVEDVKKLLGFLGMPCIDAPSEAEAQCAELCKDGLVYGVVTEDADSLTFGTPIQIKQLNFSESSNKITDKSPSKQKNGMQIIKLSLILSELDINMDQFIDLCILSGCDYCGTIRGIGTSTAYKLLKKYHNIESILKNIDQTKNPIPGNFDFSKVRELFKNPLVSKNNQIKDLIKWSNPKYEELMEWLIKEQNFNEARVNSYCERIKKSKNKTSQTCLDGFFKTASNERKNTHETPSRPPLSEKQKSETRKEVDSSLSCDKKKVKIEETKIISEWGAPVSKNLSSQAEKDLAENSSEAPNQSSEIKVNKIEENKDSESSTVENTPSLQTKSPEPTMRPVKRKLNRLISESDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ24</accession>
    <name>A3FQ24_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_1950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Nudix hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388104.1">
        <property type="nucleotide sequence ID" value="XM_001388067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ24"/>
    <dbReference type="FunCoup" id="A3FQ24">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ24"/>
    <dbReference type="GeneID" id="3374083"/>
    <dbReference type="KEGG" id="cpv:cgd3_1950"/>
    <dbReference type="InParanoid" id="A3FQ24"/>
    <dbReference type="OMA" id="WANISQV"/>
    <dbReference type="OrthoDB" id="276276at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004081">
        <property type="term" value="F:bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006167">
        <property type="term" value="P:AMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006754">
        <property type="term" value="P:ATP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051325">
        <property type="entry name" value="Nudix_hydrolase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003565">
        <property type="entry name" value="Tetra_PHTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340:SF0">
        <property type="entry name" value="BIS(5'-NUCLEOSYL)-TETRAPHOSPHATASE [ASYMMETRICAL]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21340">
        <property type="entry name" value="DIADENOSINE 5,5-P1,P4-TETRAPHOSPHATE PYROPHOSPHOHYDROLASE MUTT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01405">
        <property type="entry name" value="TETRPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="6">
        <location>
            <begin position="3"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00032644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="95" mass="11453" checksum="E59008EFEBD9B3D1" modified="2007-04-03" version="1" fragment="single">KTLFRETLEETGIGPQQIKLYNNFVKEIQYEAWNKKKTVFYYLGECMNDTKIVISHEHSEYKWANISQVRQLVEFESLIQIFNDAFERIVMEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ84</accession>
    <name>A3FQ84_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATPase, class II, type 9B, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd2_2400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388220.1">
        <property type="nucleotide sequence ID" value="XM_001388183.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A3FQ84">
        <property type="interactions" value="81"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ84"/>
    <dbReference type="GeneID" id="3373552"/>
    <dbReference type="KEGG" id="cpv:cgd2_2400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2400"/>
    <dbReference type="InParanoid" id="A3FQ84"/>
    <dbReference type="OMA" id="IAITTWH"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF5">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="343"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1088"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1166"/>
            <end position="1186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1192"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1222"/>
            <end position="1241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1253"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="9">
        <location>
            <begin position="49"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="8">
        <location>
            <begin position="136"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="10">
        <location>
            <begin position="1053"/>
            <end position="1282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1291" mass="146904" checksum="E5B61767CE7725CA" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ96</accession>
    <name>A3FQ96_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Aurora kinase</fullName>
            <ecNumber evidence="11">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_3190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="11"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388232.1">
        <property type="nucleotide sequence ID" value="XM_001388195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ96"/>
    <dbReference type="FunCoup" id="A3FQ96">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ96"/>
    <dbReference type="GeneID" id="3373542"/>
    <dbReference type="KEGG" id="cpv:cgd2_3190"/>
    <dbReference type="InParanoid" id="A3FQ96"/>
    <dbReference type="OMA" id="KNRPCIK"/>
    <dbReference type="OrthoDB" id="345735at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14007">
        <property type="entry name" value="STKc_Aurora"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000235">
        <property type="entry name" value="Serine/threonine-protein kinase ark1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 9 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="60"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="138"/>
            <end position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="187"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="201"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="10">
        <location>
            <position position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAZ51405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="358" mass="41400" checksum="E659AFD778F1E087" modified="2007-04-03" version="1">MSEHTKMAINEEMNGSEKRMTTTRVIRRNSPYLRAPRMYSISDLALACPLHCPELSISDFDIGRKLGSGQFGSVYLARERRTKYIVGLKVLRKKNLVKSGMEVQVRREIEIQAHLKHENILQLYAWFEDKSRIWLVIEIAPGGELYEKLCTDGPLKEYQAARYMKMMIEAIQCCHRKHVIHRDIKPENILIGVDGQLKLADFGWSSHINNNKSRRRTFCGTYDYLPPEITRKQEYGPEVDIWSLGVLCYELVKGEPPFPSNQGHNVQYYLIQNKQPEYSPHWSPILVGFIHSALQKLPQNRITIADMLKHPFITKYTSGETLTQEISLTENPNKNLNVESYSNNDENVCKNSKINQQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQA1</accession>
    <name>A3FQA1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">subtilisin</fullName>
            <ecNumber evidence="7">3.4.21.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd2_3660</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.</text>
            <dbReference type="EC" id="3.4.21.62"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388237.1">
        <property type="nucleotide sequence ID" value="XM_001388200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQA1"/>
    <dbReference type="STRING" id="353152.A3FQA1"/>
    <dbReference type="GeneID" id="3373537"/>
    <dbReference type="KEGG" id="cpv:cgd2_3660"/>
    <dbReference type="InParanoid" id="A3FQA1"/>
    <dbReference type="OMA" id="TIYERQW"/>
    <dbReference type="OrthoDB" id="531541at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07473">
        <property type="entry name" value="Peptidases_S8_Subtilisin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034204">
        <property type="entry name" value="PfSUB1-like_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 10" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="9">
        <location>
            <begin position="68"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="321" mass="36114" checksum="AB821C98E6499094" modified="2007-04-03" version="1" fragment="single">EFIGFEENNYRSTFEIPKINNSIRPTITTENYSTIYERQWFHNDSKFGIKSAKMWKRVSELKDQGMGNVVIAVIDSGIDFEHPDLRGKIWRNFGEFDCNDGIDDDMNGYVDDCYGWNFVDNNKIPVDNNGHGTHISGIISAIPNKEVGISGICWFCQIMVLKVLDSKIRGFLSGFVEAIDYALDKGVRVSNHSYGSRRSIELLRLAIKRSEDQGMLVIVASGNYESDRNNDIVPTFPSSFKSENIISVTSITSNGELMERATYGRKTVHIGAPGVNICSTYLQGGKMHANLKNTKLTQILTKIHSTQNIDVWMVAHSLPQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQB7</accession>
    <name>A3FQB7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_530</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NOP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388139.1">
        <property type="nucleotide sequence ID" value="XM_001388102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQB7"/>
    <dbReference type="FunCoup" id="A3FQB7">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQB7"/>
    <dbReference type="GeneID" id="3371502"/>
    <dbReference type="KEGG" id="cpv:cgd1_530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_530"/>
    <dbReference type="InParanoid" id="A3FQB7"/>
    <dbReference type="OMA" id="HRIIIKK"/>
    <dbReference type="OrthoDB" id="13807at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904874">
        <property type="term" value="P:positive regulation of telomerase RNA localization to Cajal body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.40">
        <property type="entry name" value="H/ACA ribonucleoprotein complex, subunit Nop10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007264">
        <property type="entry name" value="H/ACA_rnp_Nop10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036756">
        <property type="entry name" value="H/ACA_rnp_Nop10_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13305">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NOP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04135">
        <property type="entry name" value="Nop10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144210">
        <property type="entry name" value="Nop10-like SnoRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00030185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="60" mass="7028" checksum="93C89BC52C60281B" modified="2007-04-03" version="1" fragment="single">MFLRFYKNEKGERVYTLSAVNKEGEITFSAHPARFSPDDIYSSQRIACKKRFGLLPTQRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQN1</accession>
    <name>A3FQN1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rab11, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAZ51237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388049.1">
        <property type="nucleotide sequence ID" value="XM_001388012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQN1"/>
    <dbReference type="SMR" id="A3FQN1"/>
    <dbReference type="FunCoup" id="A3FQN1">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQN1"/>
    <dbReference type="GeneID" id="3372631"/>
    <dbReference type="KEGG" id="cpv:cgd4_320"/>
    <dbReference type="InParanoid" id="A3FQN1"/>
    <dbReference type="OMA" id="ITAIYQM"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01868">
        <property type="entry name" value="Rab11_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000067">
        <property type="entry name" value="ras-related protein RABA1f"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="220" mass="24746" checksum="580E66A0C263EAAB" modified="2007-04-03" version="1">MSSKDEHYDYLYKIVLIGDSGVGKSNLLSRFTRDEFNLESKSTIGVEFATKSIITEGKVIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDISKRSSFENVERWLKELRDHADPNIVVLLVGNKSDLRNLRTVTQEEACAFSEREGMACMEASALNSSNVDEAFHRILSEIYTLRSERQLTANQHDLNKATLPLGTQGVRVDPIRIDLNSKGSKKRSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQN9</accession>
    <name>A3FQN9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">MYND finger domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_1070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAZ51245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388057.1">
        <property type="nucleotide sequence ID" value="XM_001388020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQN9"/>
    <dbReference type="GeneID" id="3372622"/>
    <dbReference type="KEGG" id="cpv:cgd4_1070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1070"/>
    <dbReference type="InParanoid" id="A3FQN9"/>
    <dbReference type="OMA" id="MMLQMDS"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01753">
        <property type="entry name" value="zf-MYND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYND-type" evidence="5">
        <location>
            <begin position="194"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="234" mass="27187" checksum="353D711BE5BD004C" modified="2007-04-03" version="1">MDSLDEVIHEKFTYVFIPYHDSDKIEVREFSGKEVNFKNLMRSHFSSKLRSSEVSKLQETFNKESKASDQLVEQAILNSQNYEIISLVLPNKSNNFTATNAYIDSIGRIKEMPINPRASKICSTDVRGDCFISSSFDDEYVFKRVSFGEEEYNKLCKNPPSAENRWDASKISTMLNNPTDLLKSKEEDKILNRCESCRKESEKTLLICSRCKKVAYCNVDCQRKDWSYHKQFCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPI9</accession>
    <name>Q5CPI9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oocyst wall protein 9</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625360.1">
        <property type="nucleotide sequence ID" value="XM_625360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPI9"/>
    <dbReference type="STRING" id="353152.Q5CPI9"/>
    <dbReference type="GeneID" id="3375641"/>
    <dbReference type="KEGG" id="cpv:cgd6_210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_210"/>
    <dbReference type="InParanoid" id="Q5CPI9"/>
    <dbReference type="OMA" id="ICHEVDI"/>
    <dbReference type="OrthoDB" id="340128at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253708" evidence="1">
        <location>
            <begin position="23"/>
            <end position="1183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1183" mass="135945" checksum="B081395B9A18F7EB" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPY3</accession>
    <name>Q5CPY3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625496.1">
        <property type="nucleotide sequence ID" value="XM_625496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPY3"/>
    <dbReference type="GeneID" id="3372446"/>
    <dbReference type="KEGG" id="cpv:cgd8_330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_330"/>
    <dbReference type="InParanoid" id="Q5CPY3"/>
    <dbReference type="OMA" id="YTSSHWD"/>
    <dbReference type="OrthoDB" id="338336at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="133" mass="14893" checksum="911DA4D9587F5B14" modified="2005-04-12" version="1">MGPNGGMGMVQQVPGQYYQPQHVPGFNQYAGLMRPEGFPVYTTQWPSAFHGGDPTQVQAPIQTQYLPSETPVYYASAQWDTQSYLPMSYYAGAYDPNGMAYPFPQSGSFQYVQDGPVIPRKRGAKKRLFKFCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ05</accession>
    <name>Q5CQ05_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625474.1">
        <property type="nucleotide sequence ID" value="XM_625474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ05"/>
    <dbReference type="GeneID" id="3372492"/>
    <dbReference type="KEGG" id="cpv:cgd8_100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_100"/>
    <dbReference type="InParanoid" id="Q5CQ05"/>
    <dbReference type="OMA" id="YLELACI"/>
    <dbReference type="OrthoDB" id="337490at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1249" mass="143834" checksum="3853FFE1BBDA4EF0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ09</accession>
    <name>Q5CQ09_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal peptide, possible transmembrane domain near N</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_60</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625470.1">
        <property type="nucleotide sequence ID" value="XM_625470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ09"/>
    <dbReference type="GeneID" id="3372489"/>
    <dbReference type="KEGG" id="cpv:cgd8_60"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_60"/>
    <dbReference type="InParanoid" id="Q5CQ09"/>
    <dbReference type="OrthoDB" id="344104at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="200" mass="22659" checksum="D963F0558DFECC27" modified="2005-04-12" version="1">MVGTQTRILFFRLISVTFSNMSFKKFISATIFISFVLIFQGILFDSAVSPSIKQLKYSFITLPRTYSLQQGSSRGCGCSGFWSRLLNLFGSCFGSCSKSEEDEVQSPAGRYAQFQSTASGFTLHSGDLTLTCEKDGDRTVDRTKNDLRKLFDSYGRFGCTERDLRPACKELLKRIRHQMKKLNRKGMVCILFFSDVFSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ96</accession>
    <name>Q5CQ96_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_3640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625530.1">
        <property type="nucleotide sequence ID" value="XM_625530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ96"/>
    <dbReference type="GeneID" id="3372538"/>
    <dbReference type="KEGG" id="cpv:cgd5_3640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3640"/>
    <dbReference type="InParanoid" id="Q5CQ96"/>
    <dbReference type="OMA" id="ENIFSCC"/>
    <dbReference type="OrthoDB" id="343048at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="258" mass="29597" checksum="31265C5B98892E49" modified="2005-04-12" version="1">MFCRFFDQLFECCRLPNESGSNIEPEFEFEELIKNNPQCYGMMNYIHSSGACFGNTSNYSSFRPNTSIRYLTSNLRQRFGTNQLSLLPKYEAKRFEEMNFETNDMDSNFIRNIIGSGPQISNHLLNFIQILNKGIMVKQVIDLTIGDTKYIAIYLSKNLSSLILDNFGGVLLEVPLKFVLDVAFSDFSNYKKTLISQFTTRKGYEPVKLNEDIQYLVSIDLGTQMKSICLTFSSELDGMSFCTNLCNLINYLNLKRIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQB8</accession>
    <name>Q5CQB8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NADPH-dependent FMN FAD containing oxidoreductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd4_1330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625730.1">
        <property type="nucleotide sequence ID" value="XM_625730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQB8"/>
    <dbReference type="STRING" id="353152.Q5CQB8"/>
    <dbReference type="GeneID" id="3372615"/>
    <dbReference type="KEGG" id="cpv:cgd4_1330"/>
    <dbReference type="InParanoid" id="Q5CQB8"/>
    <dbReference type="OMA" id="DIMSIPR"/>
    <dbReference type="OrthoDB" id="1856718at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF10">
        <property type="entry name" value="NADPH-DEPENDENT DIFLAVIN OXIDOREDUCTASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="8">
        <location>
            <begin position="18"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="819" mass="97838" checksum="8898E8BBD5B36D79" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQE6</accession>
    <name>Q5CQE6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625702.1">
        <property type="nucleotide sequence ID" value="XM_625702.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQE6"/>
    <dbReference type="GeneID" id="3372681"/>
    <dbReference type="KEGG" id="cpv:cgd4_1010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1010"/>
    <dbReference type="InParanoid" id="Q5CQE6"/>
    <dbReference type="OMA" id="YYNHLFL"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1610"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1313"/>
            <end position="1324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1862" mass="220806" checksum="FAC95993FF342540" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQF5</accession>
    <name>Q5CQF5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625693.1">
        <property type="nucleotide sequence ID" value="XM_625693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQF5"/>
    <dbReference type="STRING" id="353152.Q5CQF5"/>
    <dbReference type="GeneID" id="3372691"/>
    <dbReference type="KEGG" id="cpv:cgd4_920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_920"/>
    <dbReference type="InParanoid" id="Q5CQF5"/>
    <dbReference type="OMA" id="SILACWI"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5012339064" evidence="3">
        <location>
            <begin position="16"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="525" mass="60950" checksum="144000C7B07D3429" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQU3</accession>
    <name>Q5CQU3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Articulin family protein, adjacent paralogous protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625909.1">
        <property type="nucleotide sequence ID" value="XM_625909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQU3"/>
    <dbReference type="STRING" id="353152.Q5CQU3"/>
    <dbReference type="GeneID" id="3372781"/>
    <dbReference type="KEGG" id="cpv:cgd4_3300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3300"/>
    <dbReference type="InParanoid" id="Q5CQU3"/>
    <dbReference type="OMA" id="DIETQYR"/>
    <dbReference type="OrthoDB" id="371494at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022086">
        <property type="entry name" value="IMCp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12314">
        <property type="entry name" value="IMCp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="264" mass="30077" checksum="C6B91E8B04133AAB" modified="2005-04-12" version="1">MPAKKNNGGQTDRDSESGLTDRQSNKVESNIVEVPELHFHEKYSAVNIPVVQEKIRYETKEVIQEREVHVVKPVVKEKIVEVPKYKVVEKVVEVPQVVVQEKLIEVERVEVTSRSRNQSRPISPVEKKQLDIVTQYRQVPKPVEVPIAFYSAIPVPILIDRAVPVPMELQIIQDILCPKIEAIYKDIPIPIPVKRTIEKPVPIGLYDQPELLQKYLHDPNEPLPNPVAALEQMAQQASMAAALNQQNMMQMMQQQGSVQQEPQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQW8</accession>
    <name>Q5CQW8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd4_3000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625884.1">
        <property type="nucleotide sequence ID" value="XM_625884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQW8"/>
    <dbReference type="STRING" id="353152.Q5CQW8"/>
    <dbReference type="GeneID" id="3372990"/>
    <dbReference type="KEGG" id="cpv:cgd4_3000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3000"/>
    <dbReference type="InParanoid" id="Q5CQW8"/>
    <dbReference type="OMA" id="ISGNDRW"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17967">
        <property type="entry name" value="DEADc_DDX3_DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000397">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044763">
        <property type="entry name" value="Ded1/Dbp1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="232"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="433"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="609"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="201"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="47"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="632"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="692"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK87812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="702" mass="78714" checksum="19245917A44FD66B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQX2</accession>
    <name>Q5CQX2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_2950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625880.1">
        <property type="nucleotide sequence ID" value="XM_625880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQX2"/>
    <dbReference type="STRING" id="353152.Q5CQX2"/>
    <dbReference type="GeneID" id="3372992"/>
    <dbReference type="KEGG" id="cpv:cgd4_2950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2950"/>
    <dbReference type="InParanoid" id="Q5CQX2"/>
    <dbReference type="OrthoDB" id="339048at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="355" mass="40223" checksum="C2A10A5D183B9855" modified="2005-04-12" version="1">MCNSYSEWNSCINNFEDPDGFEDIYNPGVGSVFTTNQFHELTLPARATIGDEYIWVSQEVEEDSVHSNQRLFEGLNATQVCNELEYSEAPNYWNNNFREYLTNFQAPNQNIYSNTNQTSLNADDTFSLSNNCGRVSSDNSSVSHTSTLHGVWVVPNRDSDTNLVTNKSKFDHSSDDVSSSIETSNSEIRRRLHFSRQKSDIMIDGTRIKTDNHKYKNNDEISMLVASGGAPLGRLDEIGGVEWYPERQSWKVVGHTGISWCVRRKTWRVWFITSGGTRATRSFNPKEHGTVAAALKVAIEFLEHKRAEKSPAQKNLRGRARRSNLYSNSFVDGFSKSNNLSLNESTYEHASDLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRE8</accession>
    <name>Q5CRE8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Carboxylic ester hydrolase</fullName>
            <ecNumber evidence="3">3.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_3070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the type-B carboxylesterase/lipase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626238.1">
        <property type="nucleotide sequence ID" value="XM_626238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRE8"/>
    <dbReference type="SMR" id="Q5CRE8"/>
    <dbReference type="STRING" id="353152.Q5CRE8"/>
    <dbReference type="ESTHER" id="crypv-q5cre8">
        <property type="family name" value="Carb_B_Root"/>
    </dbReference>
    <dbReference type="GeneID" id="3373251"/>
    <dbReference type="KEGG" id="cpv:cgd5_3070"/>
    <dbReference type="InParanoid" id="Q5CRE8"/>
    <dbReference type="OMA" id="FNIRYAR"/>
    <dbReference type="OrthoDB" id="423410at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002018">
        <property type="entry name" value="CarbesteraseB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019826">
        <property type="entry name" value="Carboxylesterase_B_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050309">
        <property type="entry name" value="Type-B_Carboxylest/Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11559">
        <property type="entry name" value="CARBOXYLESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00135">
        <property type="entry name" value="COesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00122">
        <property type="entry name" value="CARBOXYLESTERASE_B_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005143579" description="Carboxylic ester hydrolase" evidence="3">
        <location>
            <begin position="25"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Carboxylesterase type B" evidence="4">
        <location>
            <begin position="30"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU361235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="588" mass="65364" checksum="AF859FFC6A4D6AF1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRG8</accession>
    <name>Q5CRG8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626218.1">
        <property type="nucleotide sequence ID" value="XM_626218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRG8"/>
    <dbReference type="GeneID" id="3373231"/>
    <dbReference type="KEGG" id="cpv:cgd5_2820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2820"/>
    <dbReference type="InParanoid" id="Q5CRG8"/>
    <dbReference type="OrthoDB" id="342320at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254155" evidence="1">
        <location>
            <begin position="21"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="210" mass="23474" checksum="3FD5AEA098770B1A" modified="2005-04-12" version="1">MRKRIEWLLRKLIIIVGISGILRNERTSCATITPTSMFVTQNMINTSSNFCWEYSGNVMYLPITSAFSTGWDNTLLIQFDLSSYAKIIRNSSKSSYISLKTYCDSYNCTCSANSLTLKFIKICDDLCSSNTSLVKDPSTIVSAFETTGYTSENMQTAPATTLIRTDNIFKYSGMTDIAETCNFKYFTLGIVNTGGCNAWVHVNSWIIDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRK3</accession>
    <name>Q5CRK3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA binding RGG repeats plus RRM domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_2460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626183.1">
        <property type="nucleotide sequence ID" value="XM_626183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRK3"/>
    <dbReference type="SMR" id="Q5CRK3"/>
    <dbReference type="STRING" id="353152.Q5CRK3"/>
    <dbReference type="GeneID" id="3373151"/>
    <dbReference type="KEGG" id="cpv:cgd5_2460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2460"/>
    <dbReference type="InParanoid" id="Q5CRK3"/>
    <dbReference type="OMA" id="ARLDHGY"/>
    <dbReference type="OrthoDB" id="344054at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="225"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="400"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="448"/>
            <end position="857"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="466"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="493"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="514"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="530"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="568"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="589"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="747"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="788"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="837"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="857" mass="94284" checksum="8552B81F5B6C4F41" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRL9</accession>
    <name>Q5CRL9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit OST2</fullName>
            <shortName evidence="8">Oligosaccharyl transferase subunit OST2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd5_2300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Endoplasmic reticulum membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DAD/OST2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626167.1">
        <property type="nucleotide sequence ID" value="XM_626167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRL9"/>
    <dbReference type="FunCoup" id="Q5CRL9">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRL9"/>
    <dbReference type="GeneID" id="3373346"/>
    <dbReference type="KEGG" id="cpv:cgd5_2300"/>
    <dbReference type="InParanoid" id="Q5CRL9"/>
    <dbReference type="OMA" id="YCCSVGT"/>
    <dbReference type="OrthoDB" id="445566at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003038">
        <property type="entry name" value="DAD/Ost2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10705:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT DAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02109">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005588">
        <property type="entry name" value="DAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="153" mass="16901" checksum="EC2846661B4F041D" modified="2005-04-12" version="1" fragment="single">LIFIYIYIFSPIADSLLKVLSMKKSTNSKTPNSEVSSPKVPASNNILDVFQEMKQAYFSKVPENIQILDSFILFMALISIIQIIYCLLIRTTYPIDSLIGGVFCTTGTALLVSALRIQLTCPSYFGDVSPKTAFTDFVICCIVFFIGCASVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRN8</accession>
    <name>Q5CRN8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein with PHD finger and a nipped-B/Mis4/Scc2 like domain at the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_2080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626148.1">
        <property type="nucleotide sequence ID" value="XM_626148.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRN8"/>
    <dbReference type="GeneID" id="3373260"/>
    <dbReference type="KEGG" id="cpv:cgd5_2080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2080"/>
    <dbReference type="InParanoid" id="Q5CRN8"/>
    <dbReference type="OMA" id="FEHANNE"/>
    <dbReference type="OrthoDB" id="418242at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024986">
        <property type="entry name" value="Nipped-B_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12830">
        <property type="entry name" value="Nipped-B_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="471"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="609"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1330"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1759"/>
            <end position="1803"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="442"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="609"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1761"/>
            <end position="1774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1791"/>
            <end position="1803"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1803" mass="205809" checksum="9CB169441428B892" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRT0</accession>
    <name>Q5CRT0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit beta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit beta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd5_1600</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626106.1">
        <property type="nucleotide sequence ID" value="XM_626106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRT0"/>
    <dbReference type="SMR" id="Q5CRT0"/>
    <dbReference type="FunCoup" id="Q5CRT0">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRT0"/>
    <dbReference type="GeneID" id="3373092"/>
    <dbReference type="KEGG" id="cpv:cgd5_1600"/>
    <dbReference type="InParanoid" id="Q5CRT0"/>
    <dbReference type="OMA" id="SHSCAVA"/>
    <dbReference type="OrthoDB" id="269919at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051855">
        <property type="entry name" value="eIF2B_beta_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45859:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254891" description="Translation initiation factor eIF2B subunit beta" evidence="10">
        <location>
            <begin position="21"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="362" mass="41346" checksum="3C581428177EA908" modified="2005-04-12" version="1" fragment="single">NKFLYFITLPLLIFFSQFLGLMHDKKKNNDWREDLYNLIELLRRRQLIGSQAQGKKTLEVLRQIVDKYSWKNVNELISNIKEIGSEVASIDPLAFSANGTFRRLINVIRKEYIKLSVKQPSSCQYFKNSENSKGYLQDVNMCLLRSAIFEGINELLHEYGQSWDFDQCLDIFTANETILIYGYSNLVERMLTSISKKKTNLIVFILDGDPEKHSQEFAQKISLEFGINAILISDSSLFSLIPKVSKVILSAKAIFPDGSAVTLSGGYLISQTAKFFSVPIVIVSALYKLCHFPLFDTQRTNLIVPPNLFADSLKQLSNVHFAINKLDLIPDNLISIFLTENGTMSKLQLYEIFKGRFHPDDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRX1</accession>
    <name>Q5CRX1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Iwsip-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_1150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the IWS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626065.1">
        <property type="nucleotide sequence ID" value="XM_626065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRX1"/>
    <dbReference type="STRING" id="353152.Q5CRX1"/>
    <dbReference type="GeneID" id="3373069"/>
    <dbReference type="KEGG" id="cpv:cgd5_1150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1150"/>
    <dbReference type="InParanoid" id="Q5CRX1"/>
    <dbReference type="OMA" id="MPAYNIQ"/>
    <dbReference type="OrthoDB" id="21124at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051037">
        <property type="entry name" value="RNAPII_TF_IWS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46010:SF1">
        <property type="entry name" value="PROTEIN IWS1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="4">
        <location>
            <begin position="205"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="365"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="305"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="386" mass="44066" checksum="DC29941FD5ABCC4A" modified="2005-04-12" version="1">MVETNEFDSGISNNRTNRIGESIIDLELVTSEQFNSNTFPEKEQETKNLHEVKRKKRKIKKHFTQIHVNDEKNNKFVLPNNDDLRVDDFIVEDGSSDFDEDDIIRVEGGIKSSDDECDEKISNDFIEDTSLNVHKNSLGRKFSETEVRTEIREFIQLMKDAANKDEIAYSDGKVAISKLKMIDEVCKRVSMNNLSNYFISEGVLDVLSQWLSPFKDGTLPNLSIRNKILKLISNIPLGEEDITSTELGKTLCKLWKNSAETIENRQIIRTLIQRWVRLISKDRPSSLETIDKVPITPESLKSQIKSNNNESTSKKSSFHIEPRTARIPINTGYNFKVIPQNDNSSIEHNASTFTDKSIGNISINRSSRTRNRSKHAMKISLEGKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRX5</accession>
    <name>Q5CRX5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626061.1">
        <property type="nucleotide sequence ID" value="XM_626061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRX5"/>
    <dbReference type="GeneID" id="3373075"/>
    <dbReference type="KEGG" id="cpv:cgd5_1100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1100"/>
    <dbReference type="InParanoid" id="Q5CRX5"/>
    <dbReference type="OMA" id="EYHTEIL"/>
    <dbReference type="OrthoDB" id="343822at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="496" mass="57547" checksum="0A61B56EF0DF8018" modified="2005-04-12" version="1">MKNHYENSGLFQSCLEKVEDYFTLDLIKLSSNGCYNDLECLGGQLKFSCLTLPPKGLNASSEDIIVGIPVGTFNSSQLRKLAKIVENLVILEELKFFRFFDFFISFSNKDPTKKEYFLLDLTKSDGLKSDFKESNVLIETIYKKNLDNLELSETLKPLIHGTLKKKINVMQSLLDHFTKNTNLLIDQVMDKFDEKSINLNRKLETAQNKILLQEAKVNRLNDVAWKIIKQFGELKELDFSESETIFCVDISKEQLEEKTYREVLTLQEALQIRRSHGGEGLPEDFESPDKLLQFGRVEGGAPNNFEDEISPQEKEVISKNLQEGIWDPMKNNTNLNHMHFRKIDWMQTDTIHPAFIQLLKLKTNSESKDEIKNKIETCSRNKIYDPISDYKIKKLNMIDNMTENNKHSTVFSYLGRPIPNLRHQEMPCIPRQKIIESIQHSMNTEVSMNKKWKSYGRPIVKRDMKLKNPEGLRIEPLNTKVSDFEISSKDVYNILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRZ9</accession>
    <name>Q5CRZ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PP2C like phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626037.1">
        <property type="nucleotide sequence ID" value="XM_626037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRZ9"/>
    <dbReference type="STRING" id="353152.Q5CRZ9"/>
    <dbReference type="DNASU" id="3373303"/>
    <dbReference type="GeneID" id="3373303"/>
    <dbReference type="KEGG" id="cpv:cgd5_840"/>
    <dbReference type="InParanoid" id="Q5CRZ9"/>
    <dbReference type="OMA" id="RASEHCQ"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="254" mass="28944" checksum="ED1ADF7C79D39A69" modified="2005-04-12" version="1" fragment="single">SAYGSLLFKRFSITIKYRKLIVEHIEKGDLKLTEEFKNILRDLMVTTFKKADSILIEKCKAEEKHYSSCTGVVLLFIKDILVNAHIGDSRSVACTYSNSINLAQFLTIDHKPDQPLEYRRIVENGGSVEYLQNHNNKPFLRGGDFTRRRARGETPMQLQYSRAFGGKDLKPYGLSCVPDISIISLNQNNRLFIIATDGIWDLLSAQQSCDLSFYSQELGIQPARYLVNAVLEETRNRNTNCDNLTAICIMHIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS03</accession>
    <name>Q5CS03_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DUF155 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626033.1">
        <property type="nucleotide sequence ID" value="XM_626033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS03"/>
    <dbReference type="STRING" id="353152.Q5CS03"/>
    <dbReference type="GeneID" id="3373139"/>
    <dbReference type="KEGG" id="cpv:cgd5_800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_800"/>
    <dbReference type="InParanoid" id="Q5CS03"/>
    <dbReference type="OMA" id="QANRITW"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="502"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="273"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="537" mass="63056" checksum="71245EF42B815605" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS29</accession>
    <name>Q5CS29_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626007.1">
        <property type="nucleotide sequence ID" value="XM_626007.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS29"/>
    <dbReference type="GeneID" id="3373176"/>
    <dbReference type="KEGG" id="cpv:cgd5_470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_470"/>
    <dbReference type="InParanoid" id="Q5CS29"/>
    <dbReference type="OMA" id="NHNGRKI"/>
    <dbReference type="OrthoDB" id="340322at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="177" mass="20890" checksum="DE0953813C22D0D9" modified="2005-04-12" version="1">MIKYLFYSFYFQLIELDINLNINRESLSALRREYSQINQSKKNNKVTTLQGLEYSQFDISNKLLKLGDFFISTSNYIIHKYLLSEKKAISNLIEQVREERYRQVERFLNHHPNIPESSLSELSFIINSAKKDKSKFNLDNNNNNNNKNNKIGQDIKLVPVFKIFEKIENSIDLNSVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS68</accession>
    <name>Q5CS68_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_30</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625968.1">
        <property type="nucleotide sequence ID" value="XM_625968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS68"/>
    <dbReference type="GeneID" id="3373340"/>
    <dbReference type="KEGG" id="cpv:cgd5_30"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_30"/>
    <dbReference type="InParanoid" id="Q5CS68"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="134" mass="14931" checksum="9D0B4CC83F1DB7ED" modified="2005-04-12" version="1">MPSPPKSPTTDMVHTTEGEKVKSRFESKFQLGAQRTSLNSKVNSSNDSINSQTSNLGKLRARTSVSRRKQNVSKSKRRKTSLLKYTANERRLSRTNSPENRRFGTNSNTEGNDPNGSNGLQFTPILSSSDDRLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSI9</accession>
    <name>Q5CSI9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_2520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628078.1">
        <property type="nucleotide sequence ID" value="XM_628078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSI9"/>
    <dbReference type="GeneID" id="3371698"/>
    <dbReference type="KEGG" id="cpv:cgd1_2520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2520"/>
    <dbReference type="InParanoid" id="Q5CSI9"/>
    <dbReference type="OrthoDB" id="340938at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="106" mass="12345" checksum="C64DDE680572A3C0" modified="2005-04-12" version="1">MNLSKYGKRKRTEDLGIYTCEKKEIDKFYASQYECNNSGILLIPTQNNEFGQLSNSELFNHSELQKVTVDRNIENKQEVCIFDETLSKNLFEEEIVRNSTPTPTIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSK5</accession>
    <name>Q5CSK5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cyclin B, saccharomyces Clb4p like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_2320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628062.1">
        <property type="nucleotide sequence ID" value="XM_628062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSK5"/>
    <dbReference type="STRING" id="353152.Q5CSK5"/>
    <dbReference type="GeneID" id="3371671"/>
    <dbReference type="KEGG" id="cpv:cgd1_2320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2320"/>
    <dbReference type="InParanoid" id="Q5CSK5"/>
    <dbReference type="OMA" id="PTAFQFM"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046965">
        <property type="entry name" value="Cyclin_A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001771">
        <property type="entry name" value="Cyclin_A_B_D_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01332">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="209"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="7">
        <location>
            <begin position="311"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin-like" evidence="6">
        <location>
            <begin position="315"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="77"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="77"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="440" mass="48904" checksum="595CECB13C289158" modified="2005-04-12" version="1">MRSERLNKIIQGHASNSSNNITLYGENCRKLVNQGNLQVMNSQDMKNAGVITNKPITRSMTSSAGNVINISNTSMCNQKHSSKLTDANSKNSNAAKPGSKAIPGPSYNEKFNGKESPTNKENVVNPNTFAEKQLKTVGAQYTSTLEKVVNVDMNNTDASFFSEYAEAIYQTSRDLESKKEPLLFTASQVVSAQPSVGKQILEWKRSGVNLLFGLQITFNVPDEVTVIANSMLDRILGLKHFQRASEMTLVSATCFWIALKYEAAYVQGENLKIPPLPALSDVAEKCGLNIAAILFCEGVVLDALDWSIEFPKPSDYIKRYCLVFKDQYTGNKATRVESLSIYLSHLAIHEPAMMGVCASKLACACLMLAHKIEGVEESWAPAVEYYTGYTRDSLKELTRYMISNLRTIRNTENGESHASPSHYQNVRKKWWSSWGSNEWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSQ3</accession>
    <name>Q5CSQ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hypothetical coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_1740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628014.1">
        <property type="nucleotide sequence ID" value="XM_628014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSQ3"/>
    <dbReference type="STRING" id="353152.Q5CSQ3"/>
    <dbReference type="GeneID" id="3371633"/>
    <dbReference type="KEGG" id="cpv:cgd1_1740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1740"/>
    <dbReference type="InParanoid" id="Q5CSQ3"/>
    <dbReference type="OMA" id="VEHGNKV"/>
    <dbReference type="OrthoDB" id="2285710at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019153">
        <property type="entry name" value="DDRGK_dom-contain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050899">
        <property type="entry name" value="DDRGK_domain-containing"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176:SF1">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09756">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01128">
        <property type="entry name" value="DDRGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="261" mass="30487" checksum="347E3D6C4C4B054B" modified="2005-04-12" version="1">MAEHLLKEIIFSLSKKDYVWIACSFLSFLLVNYYITKWIWGSNLTSSQNEGSTRGHEILTTINTTDNQKLNNSLKRKIRIEELASKQLINAKQARKHRREAYEAKQRLKAVKCELHENKINKKVLEKLSERKKALICEQKEYEKWKLKINIDETGNEFEFGDEDLNSEYENLSKFINAITREKITNINDLSVEFNISIEDVISRINQLEEQKIIDGVITDKGQYIFISEQEWEGINFCINKNGKISKSKDLTLICNDVIAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSQ4</accession>
    <name>Q5CSQ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Haloacid dehalogenase family-like horizontal transfer into apicomplexans, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628013.1">
        <property type="nucleotide sequence ID" value="XM_628013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSQ4"/>
    <dbReference type="SMR" id="Q5CSQ4"/>
    <dbReference type="STRING" id="353152.Q5CSQ4"/>
    <dbReference type="DNASU" id="3371634"/>
    <dbReference type="GeneID" id="3371634"/>
    <dbReference type="KEGG" id="cpv:cgd1_1730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1730"/>
    <dbReference type="InParanoid" id="Q5CSQ4"/>
    <dbReference type="OMA" id="EHRFFRI"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000:SF8">
        <property type="entry name" value="HAD SUPERFAMILY HYDROLASE-LIKE, TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254915" evidence="1">
        <location>
            <begin position="23"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="414" mass="46083" checksum="0AEA7C6D6C8F2505" modified="2005-04-12" version="1">MIKKALVSTIVLAFALIKDTRSQDVILENSNGNITELDKNSSMEIMSNFTYFNASYTPLVLPFEVLDLNMSVHRSLRAKKEQRKYNCSFNCIISDLDGSLAGVGSSYIAESNSMIFGDILSSNIKFFPATGKSYTSSLKFITNGLKNSVFTGFPGVYYNGALVFGPGGIKDVLYETRINSEDALEIVKYVKKFAVSNEKSLRFESNRNGNSKYAKISNNEEKDDESADSLRLLNIAIENSNGLFVDGFEGENMKEYMSQEIDSMVHKGVNLSKFLEPREGEKIKGIFKIVIVEDPDVLLHLREHLETFVKMFGCKIYRSVPNVLEIVPQNASKLNGARLILKKLKLKFHQVAYLGDGENDLEIMSKVGFPIAAMGSTPAVSYVSRAVQTFSPETSFSSLIGEYCEAECSKKKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSR3</accession>
    <name>Q5CSR3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Chromatin protein with an AT hook and a PHD finger domain at the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_1640</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628004.1">
        <property type="nucleotide sequence ID" value="XM_628004.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3371643"/>
    <dbReference type="KEGG" id="cpv:cgd1_1640"/>
    <dbReference type="InParanoid" id="Q5CSR3"/>
    <dbReference type="OMA" id="ININISW"/>
    <dbReference type="OrthoDB" id="340442at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15517">
        <property type="entry name" value="PHD_TCF19_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013637">
        <property type="entry name" value="Lys_sp_deMease-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08429">
        <property type="entry name" value="PLU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="1939"/>
            <end position="2015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2799"/>
            <end position="2839"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="2146"/>
            <end position="2177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="2799"/>
            <end position="2809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2876" mass="333749" checksum="3EA2B6A8BDF15EE5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CST4</accession>
    <name>Q5CST4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_1410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627983.1">
        <property type="nucleotide sequence ID" value="XM_627983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CST4"/>
    <dbReference type="STRING" id="353152.Q5CST4"/>
    <dbReference type="GeneID" id="3371622"/>
    <dbReference type="KEGG" id="cpv:cgd1_1410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1410"/>
    <dbReference type="InParanoid" id="Q5CST4"/>
    <dbReference type="OMA" id="NRICKRR"/>
    <dbReference type="OrthoDB" id="364553at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="247" mass="28408" checksum="8AB9447D0840BE6A" modified="2005-04-12" version="1">MPAKEDFKPFEINNFLAEFRSQVSKRKKRFQEQPSSKHLDIFADGRAKLMVKKTNDNNYQSDIKRLIEFAIDRPSVQGENSPLSPFNTDLLFFNEDTTSSSVYFEWSCTDCPLYMPKMCNCGTKGGENLYSMVCSNESCEGLLKLPYSLIHIPLNRKINSVQSFVSENMGIPSSILIYYGKLKNSLLLVLFDKEQERSLVRALYNASESIGCIALYDIFPDNNKSRSSRRPYTTKLKYTGQIRNLYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CST5</accession>
    <name>Q5CST5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_1400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627982.1">
        <property type="nucleotide sequence ID" value="XM_627982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CST5"/>
    <dbReference type="GeneID" id="3371623"/>
    <dbReference type="KEGG" id="cpv:cgd1_1400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1400"/>
    <dbReference type="InParanoid" id="Q5CST5"/>
    <dbReference type="OrthoDB" id="340377at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="962" mass="112268" checksum="D1A25C3A829D3FA6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT14</accession>
    <name>Q5CT14_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627903.1">
        <property type="nucleotide sequence ID" value="XM_627903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT14"/>
    <dbReference type="GeneID" id="3371416"/>
    <dbReference type="KEGG" id="cpv:cgd1_450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_450"/>
    <dbReference type="InParanoid" id="Q5CT14"/>
    <dbReference type="OrthoDB" id="343746at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="425"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="376"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="430"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="588" mass="67235" checksum="BCFA0D26512364C1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT27</accession>
    <name>Q5CT27_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627890.1">
        <property type="nucleotide sequence ID" value="XM_627890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT27"/>
    <dbReference type="FunCoup" id="Q5CT27">
        <property type="interactions" value="360"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT27"/>
    <dbReference type="GeneID" id="3371381"/>
    <dbReference type="KEGG" id="cpv:cgd1_300"/>
    <dbReference type="InParanoid" id="Q5CT27"/>
    <dbReference type="OMA" id="GESDACM"/>
    <dbReference type="OrthoDB" id="278325at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1230.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001931">
        <property type="entry name" value="Ribosomal_eS21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018279">
        <property type="entry name" value="Ribosomal_eS21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038579">
        <property type="entry name" value="Ribosomal_eS21_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10442">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01249">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002148">
        <property type="entry name" value="Ribosomal_S21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00996">
        <property type="entry name" value="RIBOSOMAL_S21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="80" mass="8720" checksum="9E251BF43D978C98" modified="2005-04-12" version="1" fragment="single">NIEGKIVDLYIPRKCSATKRLIPSKEHGAVQIDVALVDDEGVATGQVVSFAISGAVRQRGESDACLNRLFNEKQMLSFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT29</accession>
    <name>Q5CT29_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Short chain dehydrogenase/reductase of the rossmann fold, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627888.1">
        <property type="nucleotide sequence ID" value="XM_627888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT29"/>
    <dbReference type="STRING" id="353152.Q5CT29"/>
    <dbReference type="GeneID" id="3371423"/>
    <dbReference type="KEGG" id="cpv:cgd1_280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_280"/>
    <dbReference type="InParanoid" id="Q5CT29"/>
    <dbReference type="OMA" id="TWAWWLT"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053011">
        <property type="entry name" value="SDR_family_member_7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269">
        <property type="entry name" value="DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44269:SF2">
        <property type="entry name" value="DEHYDROGENASE_REDUCTASE SDR FAMILY MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="367" mass="41124" checksum="77D4708CE131EF96" modified="2005-04-12" version="1">MRRALRTILNVYGFILSAFIALPVLVWGMFVTLISKYSDFNLGCLSDDISPGYFKDKVVWITGASSGIGKALALRLAKLSKESNITLSLILTSRDSKRLNQLKNDLVEEFKFPENDILVLEFDIGDLDAIDSKVDEARNWKGKIDILYNNAGIGQRAIIGSFESDEKVMMINSLGSMKISKQVLSKCFIPQKSGHLINTLSIQSYVVLPGRCAYGASKRACLSFFQALRKELNYTNWDEYLEYNYSGDKKENISPAIHLGNPNVVITNIYPGHVQTEFDSRNVLHDGSLNVGAHKLKGMASEKCSDLMVKATSNLLNEAWIAQGHELLFFYLTYYSPSVAEAIQSFLDKGFTDKIWELQKSHLKKSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT57</accession>
    <name>Q5CT57_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative patched family protein with 12 transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd2_4350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626612.1">
        <property type="nucleotide sequence ID" value="XM_626612.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373708"/>
    <dbReference type="KEGG" id="cpv:cgd2_4350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4350"/>
    <dbReference type="InParanoid" id="Q5CT57"/>
    <dbReference type="OMA" id="MHEERNA"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003392">
        <property type="entry name" value="PTHD_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF92">
        <property type="entry name" value="PATCHED-RELATED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02460">
        <property type="entry name" value="Patched"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="438"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="572"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="836"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1076"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1142"/>
            <end position="1163"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1169"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="9">
        <location>
            <begin position="437"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="17"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1281" mass="146075" checksum="CE29F60A593ADF89" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT58</accession>
    <name>Q5CT58_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Thioredoxin reductase</fullName>
            <ecNumber evidence="2">1.8.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">cgd2_4320</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the transfer of electrons from NADPH to thioredoxins TRX1, TRX2 and TRX3, which in turn act as reductants of disulfide containing proteins. Able to reduce nitroglutathione (GSNO), a compound involved in the transport of nitric oxide (NO); however, TRX1 is more efficient in reducing GSNO. Has no catalytic activity towards oxidized glutathione (GSSG).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
        <text evidence="12">Binds 1 FAD per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 14">Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.1.9" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626611.1">
        <property type="nucleotide sequence ID" value="XM_626611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT58"/>
    <dbReference type="FunCoup" id="Q5CT58">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT58"/>
    <dbReference type="GeneID" id="3373690"/>
    <dbReference type="KEGG" id="cpv:cgd2_4320"/>
    <dbReference type="InParanoid" id="Q5CT58"/>
    <dbReference type="OMA" id="NYHKLAD"/>
    <dbReference type="OrthoDB" id="5956163at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004362">
        <property type="term" value="F:glutathione-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.60:FF:000190">
        <property type="entry name" value="Thioredoxin reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016156">
        <property type="entry name" value="FAD/NAD-linked_Rdtase_dimer_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046952">
        <property type="entry name" value="GSHR/TRXR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001100">
        <property type="entry name" value="Pyr_nuc-diS_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004099">
        <property type="entry name" value="Pyr_nucl-diS_OxRdtase_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012999">
        <property type="entry name" value="Pyr_OxRdtase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006338">
        <property type="entry name" value="Thioredoxin/glutathione_Rdtase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01438">
        <property type="entry name" value="TGR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737">
        <property type="entry name" value="GLUTATHIONE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42737:SF7">
        <property type="entry name" value="THIOREDOXIN-DISULFIDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02852">
        <property type="entry name" value="Pyr_redox_dim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000350">
        <property type="entry name" value="Mercury_reductase_MerA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00368">
        <property type="entry name" value="FADPNR"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00411">
        <property type="entry name" value="PNDRDTASEI"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55424">
        <property type="entry name" value="FAD/NAD-linked reductases, dimerisation (C-terminal) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00076">
        <property type="entry name" value="PYRIDINE_REDOX_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 12 14" id="KW-0274">FAD</keyword>
    <keyword evidence="4 14" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="12" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9 14" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="16">
        <location>
            <begin position="33"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Pyridine nucleotide-disulphide oxidoreductase dimerisation" evidence="15">
        <location>
            <begin position="378"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="494"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="216"/>
            <end position="223"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="302"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="13">
        <location>
            <begin position="79"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012610"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00053237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR000350-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU003691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02852"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAK88893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="526" mass="56945" checksum="96BC904F05F4CD2B" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTE2</accession>
    <name>Q5CTE2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome regulatory subunit Rpn12 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_3370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626527.1">
        <property type="nucleotide sequence ID" value="XM_626527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTE2"/>
    <dbReference type="FunCoup" id="Q5CTE2">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTE2"/>
    <dbReference type="GeneID" id="3373698"/>
    <dbReference type="KEGG" id="cpv:cgd2_3370"/>
    <dbReference type="InParanoid" id="Q5CTE2"/>
    <dbReference type="OMA" id="HIMDGYF"/>
    <dbReference type="OrthoDB" id="8775810at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006746">
        <property type="entry name" value="26S_Psome_Rpn12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12387:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="82"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009627"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="282" mass="32766" checksum="7831262D267B59CA" modified="2005-04-12" version="1" fragment="single">AKVEIGKEQSDNLNKLSNLIKEMKILLIELPSLSLSSKEIDLTELVIARDVLEISALVSVRKKDSFGFERDFLNLQRYYIDYESVSFQNLLNYYHFIPNQLFLQILAKSENQDMIKGLYLLYLLSCDKISDFHIALEIIPPNDQENKFVSFSKKLELYLLDGNYSKIMQMQSTLPTPDYQIFFKELIDTCREKVAKCIECSYDKISIDKLKSMMRFSTNEELISFINEMSPNFNKEQVNSSNVQWKLIDNAVYFEKKTSSSSNNLDLISNALGYAIELERII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTG6</accession>
    <name>Q5CTG6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_3090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626503.1">
        <property type="nucleotide sequence ID" value="XM_626503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTG6"/>
    <dbReference type="STRING" id="353152.Q5CTG6"/>
    <dbReference type="GeneID" id="3373564"/>
    <dbReference type="KEGG" id="cpv:cgd2_3090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3090"/>
    <dbReference type="InParanoid" id="Q5CTG6"/>
    <dbReference type="OMA" id="HATKEIV"/>
    <dbReference type="OrthoDB" id="343821at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254384" evidence="2">
        <location>
            <begin position="21"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="200"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="294"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="391"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="410"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="522"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="532" mass="56972" checksum="3727886509C043A6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTI2</accession>
    <name>Q5CTI2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626487.1">
        <property type="nucleotide sequence ID" value="XM_626487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTI2"/>
    <dbReference type="GeneID" id="3373462"/>
    <dbReference type="KEGG" id="cpv:cgd2_2900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2900"/>
    <dbReference type="InParanoid" id="Q5CTI2"/>
    <dbReference type="OrthoDB" id="343046at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="171" mass="20064" checksum="A168CD9871B4292C" modified="2005-04-12" version="1">MRKFLTCIIEQKSIESTSLHEKYTKISEKCAKFGYKASESTKTQSLNCIYCYKEILQSLKEKYEDMRNIFTTDENESFGKMYIIVIYLEKFLAPKISVITRYIASTNWFMAYSASREFCGTLVIVFDLWTRVTRDFFWPYIIVASGNYLSRFSIELGKLINSNITNNNINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTL2</accession>
    <name>Q5CTL2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_2550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626457.1">
        <property type="nucleotide sequence ID" value="XM_626457.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTL2"/>
    <dbReference type="GeneID" id="3373645"/>
    <dbReference type="KEGG" id="cpv:cgd2_2550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2550"/>
    <dbReference type="InParanoid" id="Q5CTL2"/>
    <dbReference type="OMA" id="IWFLINI"/>
    <dbReference type="OrthoDB" id="341839at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254952" evidence="2">
        <location>
            <begin position="27"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1869" mass="216714" checksum="305E8A137F605B88" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTS4</accession>
    <name>Q5CTS4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Gata/ArfGAP, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_1760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626395.1">
        <property type="nucleotide sequence ID" value="XM_626395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTS4"/>
    <dbReference type="FunCoup" id="Q5CTS4">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTS4"/>
    <dbReference type="GeneID" id="3373676"/>
    <dbReference type="KEGG" id="cpv:cgd2_1760"/>
    <dbReference type="InParanoid" id="Q5CTS4"/>
    <dbReference type="OMA" id="DISWKYR"/>
    <dbReference type="OrthoDB" id="73919at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08204">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.220.150:FF:000009">
        <property type="entry name" value="stromal membrane-associated protein 1 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051718">
        <property type="entry name" value="ARF_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45705:SF1">
        <property type="entry name" value="FI20236P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="24"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="214"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="341" mass="38795" checksum="CA88DD7E011973E9" modified="2005-04-12" version="1" fragment="single">KHCLSRMMNTNGLRQNSLVQGKKENLSDILGSINGNKVCADCGAKTPRWASINLGILICIDCSGVHRHLGVHISKVKSISLDKWNSDWIKRCMKIGNYISNKYYEHKLPTGFQRPSWSSQQHSIVEQWIRDKYEFKLYTPDNMIPPSLQIDSMETTVPNEKTVLKNFEDFNKPQKYNNMVSSNLLEIELESKESSSKVEKIIDLKSNQLGSETANSSLKNKHNLENQAERALERVSSFENSEVIKIKTVKEAIEKMYENSVESPPSLNNFNKVLNTSIGSIEKSTSSEKIRKIGFDLSDKLSKTEFKIEENKSQCIVENSKKPCPFSSIDAFSIIKESFSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTW8</accession>
    <name>Q5CTW8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626351.1">
        <property type="nucleotide sequence ID" value="XM_626351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTW8"/>
    <dbReference type="GeneID" id="3373581"/>
    <dbReference type="KEGG" id="cpv:cgd2_1260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1260"/>
    <dbReference type="InParanoid" id="Q5CTW8"/>
    <dbReference type="OMA" id="ICENQIT"/>
    <dbReference type="OrthoDB" id="338456at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="811" mass="95644" checksum="CD42CF2A25476807" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTZ4</accession>
    <name>Q5CTZ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal peptide plus transmembrane domain or GPI anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626325.1">
        <property type="nucleotide sequence ID" value="XM_626325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTZ4"/>
    <dbReference type="STRING" id="353152.Q5CTZ4"/>
    <dbReference type="GeneID" id="3373603"/>
    <dbReference type="KEGG" id="cpv:cgd2_940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_940"/>
    <dbReference type="InParanoid" id="Q5CTZ4"/>
    <dbReference type="OrthoDB" id="343211at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254402" evidence="3">
        <location>
            <begin position="27"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1040"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="270"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="851"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="963"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="856"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="970"/>
            <end position="982"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1063" mass="118881" checksum="9933F64A0DE9BEC1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU16</accession>
    <name>Q5CU16_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626303.1">
        <property type="nucleotide sequence ID" value="XM_626303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU16"/>
    <dbReference type="GeneID" id="3373380"/>
    <dbReference type="KEGG" id="cpv:cgd2_670"/>
    <dbReference type="InParanoid" id="Q5CU16"/>
    <dbReference type="OMA" id="RSISIMY"/>
    <dbReference type="OrthoDB" id="337601at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="125"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="185"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="263"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="370" mass="42688" checksum="10E57CF3A164FE1C" modified="2005-04-12" version="1">MSEKNRNTEVIGKTSNSTLYEKRLGLYVLMGSVLYILAIKNKLEKGWLDTPYSWMLILFRAGPIGGMILMIPYMISNLRTQIENMCETLRLFHIKYQKKEPLTIALELFPDLDKQFNMMQSMRRYIVLGLFYFCIGESLSEISTQYSKNSNIFFQVIPISASLSRSMGTYSFCKSIIYDSKNTRNLVHVFGATTACILTFFVYILGIYISHESLIDGVRMILSQSLVGGGLEKDFLRICIYLELFVQSILLSECVIRRGKNEYASFASRISPILGSLLMIISLVLRCLHLETKMVPYYIPYLEIGPYVWGLFIFIHCIAFYIRYDDQGNNSRDEENIVYMNNKVGEQINSKQNYNNRVSSESVTIQKKNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU22</accession>
    <name>Q5CU22_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626297.1">
        <property type="nucleotide sequence ID" value="XM_626297.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU22"/>
    <dbReference type="GeneID" id="3373386"/>
    <dbReference type="KEGG" id="cpv:cgd2_610"/>
    <dbReference type="InParanoid" id="Q5CU22"/>
    <dbReference type="OMA" id="VSRYSNC"/>
    <dbReference type="OrthoDB" id="344258at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="49"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="179"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="277" mass="29375" checksum="8E9583CF3610FB50" modified="2005-04-12" version="1">MSGCSTDSKKSICKTASKSCNSKSSKISVKKETPKSTSLSSSKSRKSSLSKSSIATTKASNSHPIKKEQGTVKPVVKKTISKTSKKGGEILNHKIIKSKGSEAKAISEIVKKGVSSSTKKVTKSEVAKNKILDNIVKEISTGNKKKKPESNLKENKISKANSKEKKSASTEKATKPKSKTSSSSSKLKKLPASATSLTARKNSMKVDAKNGGDSSLRTPTRTSRLSYSSTPISSLMAANDAESDHGTTNGGAIGDLIRTPVHLVSSALRRMTKIFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU24</accession>
    <name>Q5CU24_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nucleotide-sugar transporter, UDP N-acetylglucosamine-like, signal peptide, 9 or more transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626295.1">
        <property type="nucleotide sequence ID" value="XM_626295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU24"/>
    <dbReference type="FunCoup" id="Q5CU24">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU24"/>
    <dbReference type="GeneID" id="3373656"/>
    <dbReference type="KEGG" id="cpv:cgd2_590"/>
    <dbReference type="InParanoid" id="Q5CU24"/>
    <dbReference type="OMA" id="IEEDMMT"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="160"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="198"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="298"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="322"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="450" mass="50433" checksum="9137CE1DB51D1C84" modified="2005-04-12" version="1" fragment="single">KLIEKQEQKQNINGNNSNNSDNEYMKYVALFCLIIQTVAVIFFMRISRIKKSENDELYFNSCAVVMSEILKLLSSLLIVLYSNNFNMVEFYNTLRFEVFNSFKTNILVGVPGLLYVVQNNLLFIALSNLSGAVYHVTYQLKILATAILSVIILNKQLSKIRWLSLLLLTIGAVLVQTGKSSESKTPNNSGLVAENTDNFLGLCSVLLACFTSGLAGVFVEKLLKDSKTSIWGRNVQLALYGIIFGLIGCLTGKEGLEISQKGFFFGFNTLVWFVIILQAIGGIIVAAVLKYADNILKCFGNSFSIIMSCILSWYLGDYSITLNFFAGSVLVIWSIFIYGLERAFPCSEYLLKLKLILKRNSRNKIIAKYKNLRESSSEASFDFNDQNSGTRNNHLNSLNNQNKNSNILSNSKFKNINNFINQQNQNRDNYGEIDDVIPKGLQMAIISSGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU25</accession>
    <name>Q5CU25_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626294.1">
        <property type="nucleotide sequence ID" value="XM_626294.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU25"/>
    <dbReference type="GeneID" id="3373388"/>
    <dbReference type="KEGG" id="cpv:cgd2_580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_580"/>
    <dbReference type="InParanoid" id="Q5CU25"/>
    <dbReference type="OMA" id="CHYARSA"/>
    <dbReference type="OrthoDB" id="6278596at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2095"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2095"/>
            <end position="2104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2105"/>
            <end position="2124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2231" mass="253777" checksum="DC23CB29AB50E507" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU71</accession>
    <name>Q5CU71_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_3990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626943.1">
        <property type="nucleotide sequence ID" value="XM_626943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU71"/>
    <dbReference type="GeneID" id="3373901"/>
    <dbReference type="KEGG" id="cpv:cgd3_3990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3990"/>
    <dbReference type="InParanoid" id="Q5CU71"/>
    <dbReference type="OMA" id="CTHEIAS"/>
    <dbReference type="OrthoDB" id="344131at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="509" mass="58814" checksum="EBD1C978222E204A" modified="2005-04-12" version="1">MNNYGIFELNEHADRVVVYLYLDKDLFIQFGSYMDSFNTLDSKDKCLETSIIFNNGKLWLEVKGTLDKQNSNSKFSGSMEDIIILNNNQFNLEKQLSFSNFKIFLKLPNRLQVQDVLSVSYYHDNIPSKISTGSEIKTQEATPILFSRIVLSLKNKLSLLTLSTLVTDQSWDQPNELTFIEKDESVCLDLETSLLNHLLIKKPDDHEDLTNKLNINCKKCGFLLSEYYENWVTAPLPSEMFIHGSEMLTCDNCHPVLSSNSSTYCHHDFGARPNWICLGNYHISIHTNNASLDHLLFQKESDSILDQTIETFFINDINNIYYSGKKVLYSLFCQNCGDKLGWKNYQDNHINFWKSKVLLNLISNQKVVSTLFANYSIASLAIHYIEKYLKQYSKLYIINSNEMGDIKNKDAISIYIIKKNVIKLKTQLFIGCLFEHIESQAQLYNKRSIIYNSIKISYNLDTGDVIKSNEHQIKLEKEQFCQIVRSIQENTLFNKNSYLSIPILSSDLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUC4</accession>
    <name>Q5CUC4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">RPAP1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_3390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626890.1">
        <property type="nucleotide sequence ID" value="XM_626890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUC4"/>
    <dbReference type="GeneID" id="3374123"/>
    <dbReference type="KEGG" id="cpv:cgd3_3390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3390"/>
    <dbReference type="InParanoid" id="Q5CUC4"/>
    <dbReference type="OMA" id="QSCTIEQ"/>
    <dbReference type="OrthoDB" id="348201at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039913">
        <property type="entry name" value="RPAP1/Rba50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013929">
        <property type="entry name" value="RPAP1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21483:SF18">
        <property type="entry name" value="RNA POLYMERASE II-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08620">
        <property type="entry name" value="RPAP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1113"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="domain" description="RPAP1 C-terminal" evidence="3">
        <location>
            <begin position="110"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="46"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08620"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1238" mass="145232" checksum="2E4A37D084C9A1CE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUE7</accession>
    <name>Q5CUE7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_3130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626867.1">
        <property type="nucleotide sequence ID" value="XM_626867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUE7"/>
    <dbReference type="GeneID" id="3373881"/>
    <dbReference type="KEGG" id="cpv:cgd3_3130"/>
    <dbReference type="InParanoid" id="Q5CUE7"/>
    <dbReference type="OMA" id="AYHANKV"/>
    <dbReference type="OrthoDB" id="342893at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="317" mass="36861" checksum="D535E68D406F62A2" modified="2005-04-12" version="1">MFCRVAIKIGLLELLIQIFKKQNDNCITHRLKNALLRTIIGLIRFSPTAASYTWVKLKNEISELIFSDDISMRIWGIKYISTIIKMVEADSQDCLALDFIQPLELCPSIFVLMYDECVPIRLQTIKILCRIIITQGSEKECKQLVYMGIIGLLLDVLKQNDLRNCTNSIAFPIIISLIRLIKISEKWCMIFIYSKGVEITLTYLKYSVEKIIIPVILLIFNACSYSSFHTNKVLECKTLDKLHRIKELINSEEFIRIIDQVIYSLIMKCTEYEILYSFIMNSGDPYIIENRSIQDHLKIIQKKSNKLKKFIHANKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUG4</accession>
    <name>Q5CUG4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Possible mitochondrial import inner membrane, translocase subunit TIM44</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_2930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim44 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626850.1">
        <property type="nucleotide sequence ID" value="XM_626850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUG4"/>
    <dbReference type="SMR" id="Q5CUG4"/>
    <dbReference type="FunCoup" id="Q5CUG4">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUG4"/>
    <dbReference type="GeneID" id="3374101"/>
    <dbReference type="KEGG" id="cpv:cgd3_2930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2930"/>
    <dbReference type="InParanoid" id="Q5CUG4"/>
    <dbReference type="OMA" id="PHIIDAY"/>
    <dbReference type="OrthoDB" id="10265990at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039544">
        <property type="entry name" value="Tim44-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007379">
        <property type="entry name" value="Tim44-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10721:SF1">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04280">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00978">
        <property type="entry name" value="Tim44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="Tim44-like" evidence="7">
        <location>
            <begin position="254"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="424" mass="49878" checksum="F1D0E40C3BC42500" modified="2005-04-12" version="1">MEGLSSNALTKVCINSLRYNLRQDISICRNIFLFYQSNKYYMHFTQLNNLNFRKRRCYSTFNSYFNKFVSQLKNEIKSDKILQDDIALLKKKFDNLYFKFYSNLPFINFYSSVYFINIAELYKINRFLSHIKFFTAKISSIFSRFLSSNLFSRHIEIIKVLFYDETNRNVIERELSSWKSDCNKESNSEIKTSNKKIINKNIEGKTIVPIVENSVVLHNYSLRNRLGVKLKDMLLLKNIFESEYFKTIYNGNKISKVVKEMKAINPNFKLTDFMSFFEEYILPKFMESYLKCDEHKLRLHCGDVAYRQLCSNIEKLKKMGLCLNTKILQLGNVELIGAEISDLMFSFKDCKIQTNQPEFMFTFKTQQINCLQDSNGRIISGSIDDIKELQYSIKVTPHPNANVPGLEYPYLITNLEIIGSIPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUH5</accession>
    <name>Q5CUH5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNAJ domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_2810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HscB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626839.1">
        <property type="nucleotide sequence ID" value="XM_626839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUH5"/>
    <dbReference type="FunCoup" id="Q5CUH5">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUH5"/>
    <dbReference type="GeneID" id="3373959"/>
    <dbReference type="KEGG" id="cpv:cgd3_2810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2810"/>
    <dbReference type="InParanoid" id="Q5CUH5"/>
    <dbReference type="OMA" id="TEQVNTC"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044571">
        <property type="term" value="P:[2Fe-2S] cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051259">
        <property type="term" value="P:protein complex oligomerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1280.20">
        <property type="entry name" value="HscB, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004640">
        <property type="entry name" value="HscB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036386">
        <property type="entry name" value="HscB_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009073">
        <property type="entry name" value="HscB_oligo_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00714">
        <property type="entry name" value="hscB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14021:SF15">
        <property type="entry name" value="IRON-SULFUR CLUSTER CO-CHAPERONE PROTEIN HSCB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07743">
        <property type="entry name" value="HSCB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47144">
        <property type="entry name" value="HSC20 (HSCB), C-terminal oligomerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Co-chaperone HscB C-terminal oligomerisation" evidence="3">
        <location>
            <begin position="162"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="244" mass="28482" checksum="597724CA85309E6E" modified="2005-04-12" version="1">MIFNISNEKLLVSRLISKLAPNYKILVSYFKQFPCSYLLINSNFKTNRYLRDKSNYSDMRKTFKLLNEENLSGILNMNAFQLFGLENKFSINKKSVDLSYKELMRKLHPDVSNNVNENISIHIIKQYNTVNDPFERALLLISLKSGMTRDSLINIMDTIPVNSSLLEQIFEIDDKIMEISNADFNITDFDEISKKNKFKIDNCIKSLENEFEKDNFSITKILSILKELRIYQKLSDRASSILDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUK1</accession>
    <name>Q5CUK1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_2520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626813.1">
        <property type="nucleotide sequence ID" value="XM_626813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUK1"/>
    <dbReference type="STRING" id="353152.Q5CUK1"/>
    <dbReference type="GeneID" id="3373908"/>
    <dbReference type="KEGG" id="cpv:cgd3_2520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2520"/>
    <dbReference type="InParanoid" id="Q5CUK1"/>
    <dbReference type="OMA" id="ISCYHTA"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045842">
        <property type="term" value="P:positive regulation of mitotic metaphase/anaphase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF9">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="TPR" evidence="7">
        <location>
            <begin position="339"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="573" mass="66782" checksum="0A2C5E49BAB0BBED" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUL2</accession>
    <name>Q5CUL2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Proliferation-associated protein 2G4 metalloprotease, creatinase/aminopeptidase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_2390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626802.1">
        <property type="nucleotide sequence ID" value="XM_626802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUL2"/>
    <dbReference type="FunCoup" id="Q5CUL2">
        <property type="interactions" value="571"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUL2"/>
    <dbReference type="GeneID" id="3373912"/>
    <dbReference type="KEGG" id="cpv:cgd3_2390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2390"/>
    <dbReference type="InParanoid" id="Q5CUL2"/>
    <dbReference type="OMA" id="SRMFYSE"/>
    <dbReference type="OrthoDB" id="5876363at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01089">
        <property type="entry name" value="PA2G4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000029">
        <property type="entry name" value="Proliferation-associated 2G4, a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004545">
        <property type="entry name" value="PA2G4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047113">
        <property type="entry name" value="PA2G4/ARX1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00495">
        <property type="entry name" value="crvDNA_42K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804:SF11">
        <property type="entry name" value="PROLIFERATION-ASSOCIATED PROTEIN 2G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10804">
        <property type="entry name" value="PROTEASE FAMILY M24 METHIONYL AMINOPEPTIDASE, AMINOPEPTIDASE P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M24" evidence="2">
        <location>
            <begin position="30"/>
            <end position="205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="381" mass="42383" checksum="FB14E304900CFCC7" modified="2005-04-12" version="1">MSKQEGLENVDDFCISESISNSEVVTKYYTAAEIVNSTLQYVITLCLDGADISEICRKSDSMIEEKSSSVYNKKEGGRKLDKGIAFPTCISVNEICGNFSPLPAESLKLKNGDLIKIDLGAHIDGFISICSHSIVIGTERISGKQADVLKAANTAMEVAIRTVKPGNTNTYVTSMLNKTVKEFNCNMVQGVLSHQLKRHVIDGNRVIISKETLDEKVDEFTFEENEVYGLDILVSSGEGVPRESDYRSTVFKRAIETNYNLKSPIPRQFLSEVNKRFPTLPFSLNMISDEKVARLGVSECIRHNLLYSYPVITERQGEYVASFKCTLLLLPNGSKRISGLQFTQENICDSEFKVTDEEINSILSTPLSVKKKKKNKPIVSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUM9</accession>
    <name>Q5CUM9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Proteasome subunit alpha1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_2170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626785.1">
        <property type="nucleotide sequence ID" value="XM_626785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUM9"/>
    <dbReference type="FunCoup" id="Q5CUM9">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUM9"/>
    <dbReference type="MEROPS" id="T01.971"/>
    <dbReference type="GeneID" id="3374064"/>
    <dbReference type="KEGG" id="cpv:cgd3_2170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2170"/>
    <dbReference type="InParanoid" id="Q5CUM9"/>
    <dbReference type="OMA" id="YGYDMPV"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03754">
        <property type="entry name" value="proteasome_alpha_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034642">
        <property type="entry name" value="Proteasome_subunit_alpha6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="252" mass="28043" checksum="ECF7A0882A858EF0" modified="2005-04-12" version="1">MSRLSQSLHDRHITIFSPEGKLYQIEYTFRAVKNSNITAIAIKGKDTVCIVCEKKVPNQQGQQDKLLDPAYVTSLYKVRKHIGAVMLGLAPDCRSIISKCREIAGKFAFEKGVEIPVSYLSHKIADVNQLYTQHASMRLLGASGMFISIDDEDGPSLYKIDPAGYFASYRACAVGTKEREGNNALEKIIKNEPLNSCEEVISASIDCLKTLLGVDFKAEDIEVGVVTKDMPEFRLLSVEEIDNYLTNIAERD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUR1</accession>
    <name>Q5CUR1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Protein transport protein SEC23</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">cgd3_1820</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13 14">Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="14">Cytoplasmic vesicle</location>
            <location evidence="14">COPII-coated vesicle membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="14">Endoplasmic reticulum membrane</location>
            <topology evidence="14">Peripheral membrane protein</topology>
            <orientation evidence="14">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the SEC23/SEC24 family. SEC23 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626753.1">
        <property type="nucleotide sequence ID" value="XM_626753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUR1"/>
    <dbReference type="FunCoup" id="Q5CUR1">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUR1"/>
    <dbReference type="GeneID" id="3373830"/>
    <dbReference type="KEGG" id="cpv:cgd3_1820"/>
    <dbReference type="InParanoid" id="Q5CUR1"/>
    <dbReference type="OMA" id="FPPHYAE"/>
    <dbReference type="OrthoDB" id="10256289at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11287">
        <property type="entry name" value="Sec23_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.730:FF:000005">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.380:FF:000001">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.20.10:FF:000041">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000008">
        <property type="entry name" value="Protein transport protein SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037364">
        <property type="entry name" value="Sec23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037550">
        <property type="entry name" value="Sec23_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11141:SF0">
        <property type="entry name" value="PROTEIN TRANSPORT PROTEIN SEC23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="14" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12 14" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 14" id="KW-0813">Transport</keyword>
    <keyword evidence="7 14" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="16">
        <location>
            <begin position="54"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="17">
        <location>
            <begin position="123"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="19">
        <location>
            <begin position="394"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="18">
        <location>
            <begin position="509"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="15">
        <location>
            <begin position="624"/>
            <end position="710"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00025471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU365030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EAK89276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="758" mass="84851" checksum="4D49D0202BD72817" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUV1</accession>
    <name>Q5CUV1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">IQ calmodulin-binding motif family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626713.1">
        <property type="nucleotide sequence ID" value="XM_626713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUV1"/>
    <dbReference type="GeneID" id="3373981"/>
    <dbReference type="KEGG" id="cpv:cgd3_1380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1380"/>
    <dbReference type="InParanoid" id="Q5CUV1"/>
    <dbReference type="OrthoDB" id="338227at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="652" mass="76037" checksum="2843F6DC077B846B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV76</accession>
    <name>Q5CV76_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Possible coated vesicle proteins, emp24/gp25L/p24 family, signal peptide, possible transmembrane domain at C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_5140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627393.1">
        <property type="nucleotide sequence ID" value="XM_627393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV76"/>
    <dbReference type="GeneID" id="3374233"/>
    <dbReference type="KEGG" id="cpv:cgd8_5140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5140"/>
    <dbReference type="InParanoid" id="Q5CV76"/>
    <dbReference type="OMA" id="FRYFWTH"/>
    <dbReference type="OrthoDB" id="1929172at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="8">
        <location>
            <begin position="106"/>
            <end position="291"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="293" mass="33787" checksum="AD47BC5C2958A9FF" modified="2005-04-12" version="1">MEMKGLLKVCVYIVLSLELVEKLYLISAGNILKTRHEEPVVRSTDTHWDDEHRLEKPTISDQSIDAIDLDHIFDIEESDSSPEDIKKGNFLLEWLREMKTFIPSNHFVFDLNSKADEYFYFELDEANPYILLGYYCTDDTQGRIHVTINNPESKRIYSRHGCEGVYNNKPPEDGSDDGKMDHRIKGTYTVILSNHRWHDTIRISLLVGNDSKKNKAVDKKNVDKLTSKLENVDNILSIINTENQYNWAATKTNLNMIYNADSQLVFYTAIQIISVILASAIQIYYLKTILTGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVC1</accession>
    <name>Q5CVC1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Elongation of fatty acids protein</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_4630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>an acyl-CoA + malonyl-CoA + H(+) = a 3-oxoacyl-CoA + CO2 + CoA</text>
            <dbReference type="Rhea" id="RHEA:50252"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:58342"/>
            <dbReference type="ChEBI" id="CHEBI:90726"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:50253"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the ELO family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627348.1">
        <property type="nucleotide sequence ID" value="XM_627348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVC1"/>
    <dbReference type="FunCoup" id="Q5CVC1">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVC1"/>
    <dbReference type="GeneID" id="3374447"/>
    <dbReference type="KEGG" id="cpv:cgd8_4630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4630"/>
    <dbReference type="InParanoid" id="Q5CVC1"/>
    <dbReference type="OMA" id="PISWVPI"/>
    <dbReference type="OrthoDB" id="434092at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009922">
        <property type="term" value="F:fatty acid elongase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034625">
        <property type="term" value="P:fatty acid elongation, monounsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034626">
        <property type="term" value="P:fatty acid elongation, polyunsaturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019367">
        <property type="term" value="P:fatty acid elongation, saturated fatty acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030457">
        <property type="entry name" value="ELO_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002076">
        <property type="entry name" value="ELO_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157:SF17">
        <property type="entry name" value="ELONGATION OF VERY LONG CHAIN FATTY ACIDS PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11157">
        <property type="entry name" value="FATTY ACID ACYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01151">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01188">
        <property type="entry name" value="ELO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="5 10" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="2 10" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="7 10" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="61"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="172"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="228"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="323" mass="38291" checksum="B9FB5C34AEE1E6F3" modified="2005-04-12" version="1">MIIKNNNNGYFIDNVNKIWEIPINSEHMDILKEIPWFKYLTLPIERNWNGMKLFLWTNDNYYLAHTICIIYAFFIYFGPKIMEKRKPFKLEKPLKYWNLFLALFSFIGTLRLMPYVLTNLIKYGFVSSICSPPIAPLTKGPAGLWLSLFIYSKYIELIDTFFIIARKKSLSFLHWFHHLTVLLYTWDAYVCCQTIGVFFCAINYFVHSIMYFYYYLSSCGKRPKWGMIITILQIVQMIIGTILTTSGMYYSYKHPFANVFPVEYLSQPLKVGCHFIRTNGVFACLMYISYFALFFDFFIKRYITKGTPLAEWVTANKKPTKRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVG1</accession>
    <name>Q5CVG1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized glycine-rich low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627308.1">
        <property type="nucleotide sequence ID" value="XM_627308.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVG1"/>
    <dbReference type="GeneID" id="3374628"/>
    <dbReference type="KEGG" id="cpv:cgd8_4180"/>
    <dbReference type="InParanoid" id="Q5CVG1"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="323"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="412"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="437" mass="43547" checksum="8B6D8F641349826B" modified="2005-04-12" version="1" fragment="single">XXXLXLGVGXXXXXXTGXGVNXQXXXGXGXXPQVVSGVXVNPQXXXGVGXNPPTVAPGTGVNPQISPRIGVNSQVASGIGVNPQITTGIGTNPQIAPGIGVNPQVVSGIGVNPQITPGVGINPQITTGIGVNPQITPGAGISPQVVSGTGVNPQIASGXGVNPQITTGIGVNPQVVSGVGXNPQISPRIGVNSPTVAPGIGVNPSTVASETGINLLPKPTPGVKASPQTTVIPRTGANPPIVTSSVGINPPTSIPGVRVSHHPTATPGTGINPQSFALGVRVTPPTASGVRATPPTAPGIGVHPPTIPTSELGTNPQNYASGVRVSPSTIPKIGVNPHPTTTSGTGTNPQSFASGIRISPSKTPRTGVNPPPIVSGIRINPHPTTPTPDMMSMNPTPIISGVRVNPHHTTSGXGINPTPTNPNTGIRDPFLPQTFKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVJ2</accession>
    <name>Q5CVJ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubc6p like ubiquiting conjugating enzyme E2, possible transmembrane domain at C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_3850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627277.1">
        <property type="nucleotide sequence ID" value="XM_627277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVJ2"/>
    <dbReference type="STRING" id="353152.Q5CVJ2"/>
    <dbReference type="GeneID" id="3374667"/>
    <dbReference type="KEGG" id="cpv:cgd8_3850"/>
    <dbReference type="InParanoid" id="Q5CVJ2"/>
    <dbReference type="OMA" id="DEPYEWH"/>
    <dbReference type="OrthoDB" id="1158011at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd23799">
        <property type="entry name" value="UBCc_UBE2J"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000086">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 J1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="340"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="3">
        <location>
            <begin position="50"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="237"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="368" mass="41655" checksum="B97CDAFA98083E0A" modified="2005-04-12" version="1" fragment="single">ILIFYIIASKRTVKGIRRYNWIKESDFSLDPKMHQTGARGVGSSGITSVQCLSRILREYREIQKEPSSYWCAFPINMDEPYEWHFTIKGPAGTEFEGGMYHGRIILPHSYPFSPPSLMMLTGNGRFEVGKKVCLSASNYHPELWQPAWGIRTMLDALHAFFPTPGEGAIHSLDWSPEIRKKLAKDSVNWHCNTCQETNLEALSRLSPEDQDTASKESLTHSENPLIQHINNCINESKAVEKDKKKNKETEKISDKDDEYDNTENSQKSDIYESSSLDITNKDESSSLSNEGQPSSRSFSPTQHLGTVVIPPNRLPPKISQQSIAWSFLLVKKPSNILEGVATLIDLFIGILLITIFILFVRLFSTFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVV7</accession>
    <name>Q5CVV7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627162.1">
        <property type="nucleotide sequence ID" value="XM_627162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVV7"/>
    <dbReference type="GeneID" id="3374578"/>
    <dbReference type="KEGG" id="cpv:cgd8_2620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2620"/>
    <dbReference type="InParanoid" id="Q5CVV7"/>
    <dbReference type="OMA" id="NTERYDC"/>
    <dbReference type="OrthoDB" id="339980at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="878" mass="101271" checksum="9775FC700C1B4DEB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVX0</accession>
    <name>Q5CVX0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal peptide plus possible transmembrane domain paralogs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_2480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627149.1">
        <property type="nucleotide sequence ID" value="XM_627149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVX0"/>
    <dbReference type="GeneID" id="3374274"/>
    <dbReference type="KEGG" id="cpv:cgd8_2480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2480"/>
    <dbReference type="InParanoid" id="Q5CVX0"/>
    <dbReference type="OMA" id="ITMASIM"/>
    <dbReference type="OrthoDB" id="339567at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254295" evidence="3">
        <location>
            <begin position="22"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="522"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="579" mass="65570" checksum="20BF8B1A1E0C6CBC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW08</accession>
    <name>Q5CW08_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted membrane associated protein, signal peptide plus transmembrane domain or GPI anchor at C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_2070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627111.1">
        <property type="nucleotide sequence ID" value="XM_627111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW08"/>
    <dbReference type="GeneID" id="3374498"/>
    <dbReference type="KEGG" id="cpv:cgd8_2070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2070"/>
    <dbReference type="InParanoid" id="Q5CW08"/>
    <dbReference type="OMA" id="FDTHTEL"/>
    <dbReference type="OrthoDB" id="343747at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254302" evidence="2">
        <location>
            <begin position="28"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="767"/>
            <end position="792"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="793" mass="94616" checksum="B7508D5D9B0F2080" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW56</accession>
    <name>Q5CW56_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_1560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627063.1">
        <property type="nucleotide sequence ID" value="XM_627063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW56"/>
    <dbReference type="FunCoup" id="Q5CW56">
        <property type="interactions" value="502"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW56"/>
    <dbReference type="GeneID" id="3374475"/>
    <dbReference type="KEGG" id="cpv:cgd8_1560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1560"/>
    <dbReference type="InParanoid" id="Q5CW56"/>
    <dbReference type="OMA" id="XANSGPS"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000025">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase CYP19-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="28"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="189" mass="21259" checksum="AC9E75FB3AEF0CF8" modified="2005-04-12" version="1">MIKDPELRPQRHKDNPVVFLDICLLDENNKIGRLVIELFQDIVPKTSENFRQFCTGEYKKNLKSVGYKGSTIHRVIKDFVIQGGDFVNGDGTGSTSIYNTSYFNDENFEIKHTKPGLLSMANNGSPNTNGCQFFITCNTCSWLDNKHVVFGQLLGHDSFATLKKIENATVLPPNSKPKIPIIIYECGQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW82</accession>
    <name>Q5CW82_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Structural maintenance of chromosomes protein 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_1300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SMC family. SMC5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627037.1">
        <property type="nucleotide sequence ID" value="XM_627037.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CW82">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW82"/>
    <dbReference type="GeneID" id="3374268"/>
    <dbReference type="KEGG" id="cpv:cgd8_1300"/>
    <dbReference type="InParanoid" id="Q5CW82"/>
    <dbReference type="OMA" id="DEISTSC"/>
    <dbReference type="OrthoDB" id="10254973at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45916:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecF/RecN/SMC N-terminal" evidence="5">
        <location>
            <begin position="44"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="259"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="326"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="757"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="893"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="1141"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02463"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1314" mass="153979" checksum="15D2DF4FA7DE32D5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWJ5</accession>
    <name>Q5CWJ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_4820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627809.1">
        <property type="nucleotide sequence ID" value="XM_627809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWJ5"/>
    <dbReference type="GeneID" id="3375809"/>
    <dbReference type="KEGG" id="cpv:cgd6_4820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4820"/>
    <dbReference type="InParanoid" id="Q5CWJ5"/>
    <dbReference type="OrthoDB" id="336132at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="107" mass="12107" checksum="62516BC51AECF147" modified="2005-04-12" version="1">MQCPKGAKLVSSFDNSKATCETKVTVVPDFDRRCGGEQSGWFWDGELNVCLKLRTHEPKLRCPHPRPKLGMEIGNWDTPEYEPHPIYTCLANRARAIVKGKCVNIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWJ9</accession>
    <name>Q5CWJ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative low complexity protein with 2 possible transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_4780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627805.1">
        <property type="nucleotide sequence ID" value="XM_627805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWJ9"/>
    <dbReference type="GeneID" id="3375807"/>
    <dbReference type="KEGG" id="cpv:cgd6_4780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4780"/>
    <dbReference type="InParanoid" id="Q5CWJ9"/>
    <dbReference type="OMA" id="YHNERRF"/>
    <dbReference type="OrthoDB" id="340215at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="376"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="277"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="291"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="406" mass="46769" checksum="BE60E840E699D346" modified="2005-04-12" version="1">MEMDISSSNFENDNQTNTELFESKGLMPSQYYVDLFYSQLAYSYYGSLHFHWRENFCRIIKEKGLSGLGEKSLNIDFIDPLSHLADKGITNLLNNHSDFSQDLGPQMQLTGSVYYRGDSDQVLLAQAYDSSIRNPNECEVTTEFALIAEYESQNKAFSYPGEKKYSINPWERYHISILMKAIFVFMFFDVSREFYIVLISLYFLYIRGLFDGLQDLFERISSSQPMDTTLAELRRRRAEIELEAQLIQEREQELLINSELEQVKEQTEDRAVDQENSDLPKSQINSSNGVSEDEPSQEVPQNEDFDDGSSVISTHEEAHFLDPLGVLGPNEILGASQTEELQHSSDNLRRENTTAAQENTQEHSEDSQSNNRAKTVNYLTCAIYQTIGMYIFTLMPWWNPDPTYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWM7</accession>
    <name>Q5CWM7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large protein with ARM repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627777.1">
        <property type="nucleotide sequence ID" value="XM_627777.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CWM7"/>
    <dbReference type="STRING" id="353152.Q5CWM7"/>
    <dbReference type="GeneID" id="3375910"/>
    <dbReference type="KEGG" id="cpv:cgd6_4460"/>
    <dbReference type="InParanoid" id="Q5CWM7"/>
    <dbReference type="OMA" id="YVNGVHD"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22895:SF0">
        <property type="entry name" value="ARMADILLO REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2558" mass="278388" checksum="EA289AD0B95431F4" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWQ0</accession>
    <name>Q5CWQ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TBC domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627754.1">
        <property type="nucleotide sequence ID" value="XM_627754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWQ0"/>
    <dbReference type="STRING" id="353152.Q5CWQ0"/>
    <dbReference type="GeneID" id="3375907"/>
    <dbReference type="KEGG" id="cpv:cgd6_4220"/>
    <dbReference type="InParanoid" id="Q5CWQ0"/>
    <dbReference type="OMA" id="WESWKVA"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="78"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="372" mass="43286" checksum="FF66AF65506555CF" modified="2005-04-12" version="1" fragment="single">LGLLHLHMSSFVSTSSSRCQTEENELEQAIRECKELLQDSPQLLYEHSYKKWNRMINKGLDYFVKEHPKTLRRRLARGVPQDFRWKIWNSLLQISSLDDEDKINEKVSQSLRNSNFFLEIFNINDQNSPNFQSPTINFIYCNYYDYAAKFLNKYSPLISIDVPRTFPELNIFRDQASQECLFRVLNATANHIPDVGYCQGMNFIAALLLITSNFDQERSFYSLILILETYGLSGFYKDQFPLLTKYIQAFDTMFQTNIPKLWKHFQDEGIFDPVYLHPWFLTLFVSTLPLKTVVIIWDYLLANGLQSLISIAIALLKTLESSLIGQSMENIIQFFKSLRISVGINDVTCARMLLSKAKNIHISEEILATFKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWS3</accession>
    <name>Q5CWS3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Hydroxyproline-rich glycoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627731.1">
        <property type="nucleotide sequence ID" value="XM_627731.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWS3"/>
    <dbReference type="STRING" id="353152.Q5CWS3"/>
    <dbReference type="GeneID" id="3375905"/>
    <dbReference type="KEGG" id="cpv:cgd6_3940"/>
    <dbReference type="InParanoid" id="Q5CWS3"/>
    <dbReference type="OMA" id="NTRRQRE"/>
    <dbReference type="OrthoDB" id="10606193at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039190">
        <property type="entry name" value="TTC14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184:SF10">
        <property type="entry name" value="ARGININE RICH PROTEIN (AFU_ORTHOLOGUE AFUA_1G12120)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23184">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="232"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="296" mass="33537" checksum="85FEF1159E316A63" modified="2005-04-12" version="1" fragment="single">DKTGLSDKLLSFLKQKEKDQDNNPDDDDDDDNEREREREREREREREREREREREKEREREREREKEREREREREKEREREREREKERERERDMNKNKYGPTRKTGDGSSSAALAKVLMSKMGLQSQPIISPLKSTKPPLPPKPNLTYGPQPFPLGQVPGPYQSGGSTFPPPPPPPPPPPPPLQAPSNEDFPPPPPPPPPPPPLPSPPPPTLPPPPSLPPYPVPGSQSSMPMPMPMPMPMPMPMPMPMPMPTNQPYAPISQAPRPLPQLGSYFTPRPWKGGDNSSNGPKDSTGDDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWW2</accession>
    <name>Q5CWW2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_3490</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627692.1">
        <property type="nucleotide sequence ID" value="XM_627692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWW2"/>
    <dbReference type="STRING" id="353152.Q5CWW2"/>
    <dbReference type="GeneID" id="3375898"/>
    <dbReference type="KEGG" id="cpv:cgd6_3490"/>
    <dbReference type="InParanoid" id="Q5CWW2"/>
    <dbReference type="OMA" id="NCDGEYI"/>
    <dbReference type="OrthoDB" id="2573941at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051847">
        <property type="entry name" value="RNA_proc/Spliceosome_comp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45880:SF1">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN, X-LINKED 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="5"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="153" mass="17345" checksum="C6A76102704B6274" modified="2005-04-12" version="1" fragment="single">YKNSSYIYISGLDLRLTEGDIAIIFSQWGEPIDINLIRDKKLGISKGYCFLCYEDQKSTILAVDNANDMILLGKHIKVDHVRDYKPNCDGEYIFTGAEGSGIGVFGVTKDIQTRFKTELDILNLNFSNKIRGRSDNIEKKRRAKSLSRSLSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX37</accession>
    <name>Q5CX37_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627617.1">
        <property type="nucleotide sequence ID" value="XM_627617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX37"/>
    <dbReference type="GeneID" id="3376146"/>
    <dbReference type="KEGG" id="cpv:cgd6_2640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2640"/>
    <dbReference type="InParanoid" id="Q5CX37"/>
    <dbReference type="OMA" id="IKFRIMI"/>
    <dbReference type="OrthoDB" id="342964at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="260"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="366"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="411"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="535"/>
            <end position="558"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="569" mass="65203" checksum="CA91C799EED40445" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX40</accession>
    <name>Q5CX40_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ERCC1 excision repair 1 C-terminal HhH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_2610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERCC1/RAD10/SWI10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627614.1">
        <property type="nucleotide sequence ID" value="XM_627614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX40"/>
    <dbReference type="FunCoup" id="Q5CX40">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX40"/>
    <dbReference type="GeneID" id="3375886"/>
    <dbReference type="KEGG" id="cpv:cgd6_2610"/>
    <dbReference type="InParanoid" id="Q5CX40"/>
    <dbReference type="OMA" id="PHCVLVH"/>
    <dbReference type="OrthoDB" id="10262814at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070522">
        <property type="term" value="C:ERCC4-ERCC1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22325">
        <property type="entry name" value="ERCC1_C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000001">
        <property type="entry name" value="DNA excision repair protein ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047260">
        <property type="entry name" value="ERCC1-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004579">
        <property type="entry name" value="ERCC1/RAD10/SWI10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00597">
        <property type="entry name" value="rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749:SF0">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12749">
        <property type="entry name" value="EXCISION REPAIR CROSS-COMPLEMENTING 1 ERCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14520">
        <property type="entry name" value="HHH_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03834">
        <property type="entry name" value="Rad10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC1-like central" evidence="7">
        <location>
            <begin position="41"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="240" mass="27152" checksum="FA1D1380A705C09A" modified="2005-04-12" version="1" fragment="single">SDKSIFRVYFIWKSLIMSSQEEDIVKKESQPKFFDDKAGEMIIASTRQRGNPILAHVCNVPYDFQNIVPDFLVGKYDAVVFISIKYHKLHNQYLRKRIESLQKNYKVRILLCLVDIPPSGAIDAAILEVTDICFDLNMTLFLAWSPKEAGHILETLKSHENSSSEIIRGGLSLDLFSRIRDALSSLPRINKTDSENLLKHFGSISKVVNASEEELSKIQGIGPIKAKVISEIFSTEFSDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXB3</accession>
    <name>Q5CXB3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_1750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627541.1">
        <property type="nucleotide sequence ID" value="XM_627541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXB3"/>
    <dbReference type="STRING" id="353152.Q5CXB3"/>
    <dbReference type="GeneID" id="3376123"/>
    <dbReference type="KEGG" id="cpv:cgd6_1750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1750"/>
    <dbReference type="InParanoid" id="Q5CXB3"/>
    <dbReference type="OMA" id="AESHCGQ"/>
    <dbReference type="OrthoDB" id="5428259at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="9"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="330" mass="37218" checksum="4C151353CEFE8CDC" modified="2007-04-03" version="1">MQSLSTKKLNSQKHYEFLLDLYSNKETVNSLLSYPIKMSGLFWGIGSMKLLFNNLQSEDRNQIKKLETRIFEFVESCKVFVDGDVTMVGYSQNKGLNANIVSTHYALLILIMIGKLDQADSAKISKWISSLQNKDGSFRCDQYLETDCRFSYCALSSLTILNRINEIDIIGARSYLLRCYNSDGAFGGVPCSESHAAYTYCCVVSLALLNSLDIINIDRLAFWLCERQLLCGGFNGRPEKAPDVCYSWWIFSLLYFLGRANYIDKNLLEEYIFCSEDISKGGFSDRPGNVSDVFHTFFGISALSLIRFDAIDNIISPIFAVPLNLVPGDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXC1</accession>
    <name>Q5CXC1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ygr210cp-like GTP binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_1670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627533.1">
        <property type="nucleotide sequence ID" value="XM_627533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXC1"/>
    <dbReference type="STRING" id="353152.Q5CXC1"/>
    <dbReference type="GeneID" id="3375876"/>
    <dbReference type="KEGG" id="cpv:cgd6_1670"/>
    <dbReference type="InParanoid" id="Q5CXC1"/>
    <dbReference type="OMA" id="WILGNLM"/>
    <dbReference type="OrthoDB" id="545683at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04938">
        <property type="entry name" value="TGS_Obg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01899">
        <property type="entry name" value="Ygr210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013646">
        <property type="entry name" value="YGR210-like_G4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF1">
        <property type="entry name" value="OBG-TYPE G DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08438">
        <property type="entry name" value="YGR210-like_G4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="2">
        <location>
            <begin position="19"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="443" mass="50187" checksum="F5F8B9B67BB47306" modified="2005-04-12" version="1" fragment="single">IAQVKFLAKTIMTSIQKEYIIGCVGKPSSGKSTFFSSITDNPAKIGNYPFTTIEPNVGITHYIAECPCKKYNVICKPKYGNCNNGYRYVPIKMLDIAGLIPGAHLGNGLGNKFLDDLRHAHVLLHIIDISGNTNEKGEYTTNYNPINDHEWLRIEIEMWIFNNINSNWSSVVRKSKTSDISISKLLLNQFSGYGCNELMISKLISSMKLKDSVDFSNWDKTNILDLVRQFIKIRFPFVLVLNKADIMSESSDSNIVKFYEKYGSDHEIVVASSLAEYFIKKMVRQNYIKLVYDSNNYNYSSFITSEDIHNEESHGLKLIDDKLKSRLENIKDMVLFRHGVTGVQDAVNKAVDLLGLIPIYPVKNIKTFTNNLHDETNNSAFQDCILVPNGTMVKTLLKSLHIDLEKNLVNIETVGGIKISENHILSNQMNVIKITTVSYDEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXJ4</accession>
    <name>Q5CXJ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627460.1">
        <property type="nucleotide sequence ID" value="XM_627460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXJ4"/>
    <dbReference type="GeneID" id="3376084"/>
    <dbReference type="KEGG" id="cpv:cgd6_860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_860"/>
    <dbReference type="InParanoid" id="Q5CXJ4"/>
    <dbReference type="OMA" id="YTINSRD"/>
    <dbReference type="OrthoDB" id="341518at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035426">
        <property type="entry name" value="Gemin2/Brr1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04938">
        <property type="entry name" value="SIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="259" mass="30372" checksum="833AC7A0E2FB5334" modified="2007-04-03" version="1">MGKRRQKQSLNDLDIAQKLALPVDEVTEDPEYQEAMNYLKSVREEAKLITACKVYTNELESDKEETLTTKVKDTKNNITDNQNPQCNCNYGDFEYLTNYHISENLSIIRKDPAYDKCKSEIIEYILSQKEKVSTLTEALQTEEIISVSNWEEIIQSAQIPCITIGKWNSYNWSNLLEYFANQFDESTLDSFLLDTNKIQWVILALISVHTIDSYNPHVSFCMQRIKRYLESNDFSHLSKDDHFRIETIIIIIKYIYNQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXK9</accession>
    <name>Q5CXK9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Extacellular protein with a signal peptide, clostripain like caspase/hemoglobinase domain, notch domain and 2 EGF domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627445.1">
        <property type="nucleotide sequence ID" value="XM_627445.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXK9"/>
    <dbReference type="GeneID" id="3376053"/>
    <dbReference type="KEGG" id="cpv:cgd6_670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_670"/>
    <dbReference type="InParanoid" id="Q5CXK9"/>
    <dbReference type="OMA" id="FRHINIT"/>
    <dbReference type="OrthoDB" id="339125at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00053">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000038">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024731">
        <property type="entry name" value="NELL2-like_EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005077">
        <property type="entry name" value="Peptidase_C11"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37835">
        <property type="entry name" value="ALPHA-CLOSTRIPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37835:SF1">
        <property type="entry name" value="ALPHA-CLOSTRIPAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12947">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03415">
        <property type="entry name" value="Peptidase_C11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 5" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1528"/>
            <end position="1555"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1154"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="1308"/>
            <end position="1353"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1607" mass="185586" checksum="58C66D5316FB8260" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXL0</accession>
    <name>Q5CXL0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Secreted pepsinogen like aspartyl protease having a signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627444.1">
        <property type="nucleotide sequence ID" value="XM_627444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXL0"/>
    <dbReference type="SMR" id="Q5CXL0"/>
    <dbReference type="STRING" id="353152.Q5CXL0"/>
    <dbReference type="GeneID" id="3376052"/>
    <dbReference type="KEGG" id="cpv:cgd6_660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_660"/>
    <dbReference type="InParanoid" id="Q5CXL0"/>
    <dbReference type="OMA" id="HQKFCCD"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05471">
        <property type="entry name" value="pepsin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034164">
        <property type="entry name" value="Pepsin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253947" evidence="7">
        <location>
            <begin position="24"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="8">
        <location>
            <begin position="191"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="71"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="71"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="209"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="633" mass="73757" checksum="1EC49874842055E9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXL8</accession>
    <name>Q5CXL8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ser/Thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627436.1">
        <property type="nucleotide sequence ID" value="XM_627436.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXL8"/>
    <dbReference type="GeneID" id="3376048"/>
    <dbReference type="KEGG" id="cpv:cgd6_540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_540"/>
    <dbReference type="InParanoid" id="Q5CXL8"/>
    <dbReference type="OMA" id="GMTINTE"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="352"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="927"/>
            <end position="946"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="946" mass="111067" checksum="E5F94D11BDBD5712" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXZ2</accession>
    <name>Q5CXZ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Very large secreted protein, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628588.1">
        <property type="nucleotide sequence ID" value="XM_628586.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372169"/>
    <dbReference type="KEGG" id="cpv:cgd7_4340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4340"/>
    <dbReference type="InParanoid" id="Q5CXZ2"/>
    <dbReference type="OMA" id="MINIAKM"/>
    <dbReference type="OrthoDB" id="338774at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254631" evidence="2">
        <location>
            <begin position="27"/>
            <end position="3242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3190"/>
            <end position="3215"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="3242" mass="374837" checksum="7BC7EC51141067AA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXZ5</accession>
    <name>Q5CXZ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular protein with a signal peptide and 4 SCP domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628585.1">
        <property type="nucleotide sequence ID" value="XM_628583.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXZ5"/>
    <dbReference type="GeneID" id="3372165"/>
    <dbReference type="KEGG" id="cpv:cgd7_4310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4310"/>
    <dbReference type="InParanoid" id="Q5CXZ5"/>
    <dbReference type="OMA" id="GINSANM"/>
    <dbReference type="OrthoDB" id="337038at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254360" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="867"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="1192"/>
            <end position="1340"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1665" mass="184949" checksum="232199AAACB9381C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXZ9</accession>
    <name>Q5CXZ9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Phosphoglycerate mutase</fullName>
            <ecNumber evidence="8">5.4.2.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_4270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="11" key="2">
        <citation type="journal article" date="2011" name="Mol. Biochem. Parasitol." volume="179" first="69" last="79">
            <title>Characterization of a new phosphatase from Plasmodium.</title>
            <authorList>
                <person name="Hills T."/>
                <person name="Srivastava A."/>
                <person name="Ayi K."/>
                <person name="Wernimont A.K."/>
                <person name="Kain K."/>
                <person name="Waters A.P."/>
                <person name="Hui R."/>
                <person name="Pizarro J.C."/>
            </authorList>
            <dbReference type="PubMed" id="21689687"/>
            <dbReference type="DOI" id="10.1016/j.molbiopara.2011.06.001"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.01 ANGSTROMS) OF 2-249</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>(2R)-2-phosphoglycerate = (2R)-3-phosphoglycerate</text>
            <dbReference type="Rhea" id="RHEA:15901"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:58289"/>
            <dbReference type="EC" id="5.4.2.11"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.11" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628581.1">
        <property type="nucleotide sequence ID" value="XM_628579.1"/>
    </dbReference>
    <dbReference type="PDB" id="3D8H">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.01 A"/>
        <property type="chains" value="A/B=2-249"/>
    </dbReference>
    <dbReference type="PDBsum" id="3D8H"/>
    <dbReference type="AlphaFoldDB" id="Q5CXZ9"/>
    <dbReference type="SMR" id="Q5CXZ9"/>
    <dbReference type="FunCoup" id="Q5CXZ9">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXZ9"/>
    <dbReference type="GeneID" id="3372079"/>
    <dbReference type="KEGG" id="cpv:cgd7_4270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4270"/>
    <dbReference type="InParanoid" id="Q5CXZ9"/>
    <dbReference type="OMA" id="YSHNCEK"/>
    <dbReference type="OrthoDB" id="354304at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CXZ9"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004619">
        <property type="term" value="F:phosphoglycerate mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1240:FF:000003">
        <property type="entry name" value="2,3-bisphosphoglycerate-dependent phosphoglycerate mutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01039">
        <property type="entry name" value="PGAM_GpmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001345">
        <property type="entry name" value="PG/BPGM_mutase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005952">
        <property type="entry name" value="Phosphogly_mut1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01258">
        <property type="entry name" value="pgm_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010713">
        <property type="entry name" value="PRK14115.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11931">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000709">
        <property type="entry name" value="6PFK_2-Ptase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00175">
        <property type="entry name" value="PG_MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Tele-phosphohistidine intermediate" evidence="5">
        <location>
            <position position="10"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="5">
        <location>
            <position position="88"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="9"/>
            <end position="16"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="22"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="88"/>
            <end position="91"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="115"/>
            <end position="116"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="184"/>
            <end position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000380"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR613078-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="3D8H"/>
        </source>
    </evidence>
    <sequence length="249" mass="28268" checksum="4366E2D05C2ABC24" modified="2005-04-12" version="1">MTYKLTLIRHGESEWNKENRFTGWTDVSLSEQGVSEAIEAGRMLLEKGFKFDVVYTSVLKRAIMTTWTVLKELGNINCPIINHWRLNERHYGALQGLNKSETASKFGEDQVKIWRRSFDVPPPVLEKSDPRWPGNELIYKGICPSCLPTTECLKDTVERVKPYFEDVIAPSIMSGKSVLVSAHGNSLRALLYLLEGMTPEQILEVNIPTACPLVLELDDYLKVTKKYYLISEEELKAKMEAVANQGKAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY17</accession>
    <name>Q5CY17_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 9">Signal recognition particle subunit SRP72</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd7_4060</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the SRP72 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628563.1">
        <property type="nucleotide sequence ID" value="XM_628561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY17"/>
    <dbReference type="STRING" id="353152.Q5CY17"/>
    <dbReference type="GeneID" id="3372067"/>
    <dbReference type="KEGG" id="cpv:cgd7_4060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4060"/>
    <dbReference type="InParanoid" id="Q5CY17"/>
    <dbReference type="OMA" id="NDMKVLA"/>
    <dbReference type="OrthoDB" id="5421607at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013699">
        <property type="entry name" value="Signal_recog_part_SRP72_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026270">
        <property type="entry name" value="SRP72"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031545">
        <property type="entry name" value="SRP72_TPR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14094:SF9">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08492">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17004">
        <property type="entry name" value="SRP_TPR_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038922">
        <property type="entry name" value="SRP72"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="Signal recognition particle SRP72 subunit RNA-binding" evidence="11">
        <location>
            <begin position="566"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="559"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="559"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="584"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="609"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="621"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="645"/>
            <end position="671"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR038922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="680" mass="77643" checksum="54498A1EB7084248" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY86</accession>
    <name>Q5CY86_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ER lumen protein retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd7_3300</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628494.1">
        <property type="nucleotide sequence ID" value="XM_628492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY86"/>
    <dbReference type="GeneID" id="3372054"/>
    <dbReference type="KEGG" id="cpv:cgd7_3300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3300"/>
    <dbReference type="InParanoid" id="Q5CY86"/>
    <dbReference type="OMA" id="HRERSAC"/>
    <dbReference type="OrthoDB" id="434428at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="45"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="148"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="211"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="246"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="32671" checksum="37DDE27E158C66E9" modified="2005-04-12" version="1">MQKKPIFHNFAFILDVINFATALSWFCAYLALFLKLKREKNVVGLSLQTILMLVVAECNHVLITAVLSSHYHVELGLDFYLCDCSTALLSAVTFAYIYFNFYETYESNRDTFGLNVTNFIICWISRAGRSNHFIQKKSNKYYPTSQKIFWLTVYILNFFLGSIIFFLRKSSSPPIISFWESYMDSLLSLALLPQIFMFYNKKPRKVSSLLAHFVAFILLARVFMLFYWILYPLFKLSIVPGRRLHIFSESLNVTFLMHFMYYFIRSKLNGENDIFLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY87</accession>
    <name>Q5CY87_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cleft lip and palate family of eukaryotic membrane proteins (Potential transporters) with 9 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_3290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CLPTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628493.1">
        <property type="nucleotide sequence ID" value="XM_628491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY87"/>
    <dbReference type="FunCoup" id="Q5CY87">
        <property type="interactions" value="65"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY87"/>
    <dbReference type="GeneID" id="3372047"/>
    <dbReference type="KEGG" id="cpv:cgd7_3290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3290"/>
    <dbReference type="InParanoid" id="Q5CY87"/>
    <dbReference type="OMA" id="NDISFWH"/>
    <dbReference type="OrthoDB" id="378564at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008429">
        <property type="entry name" value="CLPTM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347">
        <property type="entry name" value="CLEFT LIP AND PALATE ASSOCIATED TRANSMEMBRANE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21347:SF0">
        <property type="entry name" value="LIPID SCRAMBLASE CLPTM1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05602">
        <property type="entry name" value="CLPTM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="334"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="366"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="397"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="490"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="531"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="593"/>
            <end position="621"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="621" mass="72537" checksum="2F0C865011472D02" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYC0</accession>
    <name>Q5CYC0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628460.1">
        <property type="nucleotide sequence ID" value="XM_628458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYC0"/>
    <dbReference type="GeneID" id="3372276"/>
    <dbReference type="KEGG" id="cpv:cgd7_2930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2930"/>
    <dbReference type="InParanoid" id="Q5CYC0"/>
    <dbReference type="OrthoDB" id="342606at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="34"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="220" mass="24703" checksum="227F77E7A285CB02" modified="2005-04-12" version="1">MNSRYPGYDNEFNSNLAESFELDTDLNQLALQRGEAREKTNASIENSSSDHTAQNANGSLANKIKMNRSRNPKKSTSNQSSGIISSFKSWTHSLIAHSSRQNCQGRRQRPRNIDTTVNMETANTECHGSISQIENRESNILRTEISDEELARRIQIEELNGIGSFHIMEDSSNLPLYSLGSFQDANYYPNVTVSSSESTAISPFQGVSYKFEFRSSDDEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYF2</accession>
    <name>Q5CYF2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2</fullName>
            <ecNumber evidence="1">2.1.1.296</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_2570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(ribonucleotide) in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-(2'-O-methyl-ribonucleoside)-(2'-O-methyl-ribonucleotide) in mRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67024"/>
            <dbReference type="Rhea" id="RHEA-COMP:17169"/>
            <dbReference type="Rhea" id="RHEA-COMP:17170"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:167612"/>
            <dbReference type="ChEBI" id="CHEBI:167614"/>
            <dbReference type="EC" id="2.1.1.296"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.296" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628428.1">
        <property type="nucleotide sequence ID" value="XM_628426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYF2"/>
    <dbReference type="STRING" id="353152.Q5CYF2"/>
    <dbReference type="GeneID" id="3371924"/>
    <dbReference type="KEGG" id="cpv:cgd7_2570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2570"/>
    <dbReference type="InParanoid" id="Q5CYF2"/>
    <dbReference type="OMA" id="CINVSNT"/>
    <dbReference type="OrthoDB" id="429597at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004483">
        <property type="term" value="F:methyltransferase cap1 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120550">
        <property type="term" value="F:methyltransferase cap2 activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016556">
        <property type="term" value="P:mRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12760">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025807">
        <property type="entry name" value="Adrift-typ_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050851">
        <property type="entry name" value="mRNA_Cap_2O-Ribose_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16121:SF2">
        <property type="entry name" value="CAP-SPECIFIC MRNA (NUCLEOSIDE-2'-O-)-METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51614">
        <property type="entry name" value="SAM_MT_ADRIFT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adrift-type SAM-dependent 2'-O-MTase" evidence="7">
        <location>
            <begin position="103"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00021134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1188" mass="137809" checksum="A2F7A80F8330FD48" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYI5</accession>
    <name>Q5CYI5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Kinesin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_2210</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628395.1">
        <property type="nucleotide sequence ID" value="XM_628393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYI5"/>
    <dbReference type="GeneID" id="3371897"/>
    <dbReference type="KEGG" id="cpv:cgd7_2210"/>
    <dbReference type="InParanoid" id="Q5CYI5"/>
    <dbReference type="OrthoDB" id="343826at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="249" mass="29134" checksum="F8D072347022B568" modified="2005-04-12" version="1">MITFSPNKYISPKAIKEALNSNENENMNLDLKQRLEFIEEMLKKEDAPLPGDSQLFNIHLSRQLFPQLKFEDIPDIKGVPVEELIILSSSGILPNMGDFEYTLNSIRNELIEAERIKGSFEDPLDSRLARRHVLIKELPPISANDDELVEWEMEQREKMLREEYDEHNRRKFKLQLLPLDRSSDVPNLKLKSPDKKIGKIEVSDEEVQKLRNYEKSMYPEFIKKTDKLAREVSSLFQNNIFYSIILILG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYJ3</accession>
    <name>Q5CYJ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">60S ribosomal proteins L8/L2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_2110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628387.1">
        <property type="nucleotide sequence ID" value="XM_628385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYJ3"/>
    <dbReference type="FunCoup" id="Q5CYJ3">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYJ3"/>
    <dbReference type="GeneID" id="3371890"/>
    <dbReference type="KEGG" id="cpv:cgd7_2110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2110"/>
    <dbReference type="InParanoid" id="Q5CYJ3"/>
    <dbReference type="OMA" id="GGRHPCT"/>
    <dbReference type="OrthoDB" id="10267824at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.950.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000006">
        <property type="entry name" value="60S ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000581">
        <property type="entry name" value="Ribosomal protein L8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.950.10">
        <property type="entry name" value="Ribosomal protein L2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002171">
        <property type="entry name" value="Ribosomal_uL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023672">
        <property type="entry name" value="Ribosomal_uL2_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022669">
        <property type="entry name" value="Ribosomal_uL2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022671">
        <property type="entry name" value="Ribosomal_uL2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014726">
        <property type="entry name" value="Ribosomal_uL2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022666">
        <property type="entry name" value="Ribosomal_uL2_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007180">
        <property type="entry name" value="PRK09612.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13691">
        <property type="entry name" value="RIBOSOMAL PROTEIN L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03947">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00181">
        <property type="entry name" value="Ribosomal_L2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002158">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01383">
        <property type="entry name" value="Ribosomal_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01382">
        <property type="entry name" value="Ribosomal_L2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00467">
        <property type="entry name" value="RIBOSOMAL_L2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL2 RNA-binding" evidence="9">
        <location>
            <begin position="11"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL2 C-terminal" evidence="8">
        <location>
            <begin position="96"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="261" mass="28153" checksum="A5790D0C5EF225FF" modified="2005-04-12" version="1">MGRVIRGQRKGAGSIFKAKVSKRRGPVKLRALDYIERHGYIKGLVKDITTDPGRGCPVAHVSFRDPYRYKIKKELMIAVEGLHTGQFVYCGKNATLSVGNVLPVGQIPEGTIISSCEEKAGDRGKLARTSGTYAIIVGQSEDGTKTRIRLPSGARKTISSQSRAIIGIVAAGGRIDKPVLKAGNNYHKYKVKRNCWPKVRGVSMNPVDHPHGGGNHQHIGHPSTVSRSAPPGQKVGLIAARRTGLLRGGRKTAKDKVEKGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYW4</accession>
    <name>Q5CYW4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628266.1">
        <property type="nucleotide sequence ID" value="XM_628264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372019"/>
    <dbReference type="KEGG" id="cpv:cgd7_770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_770"/>
    <dbReference type="InParanoid" id="Q5CYW4"/>
    <dbReference type="OMA" id="ESNIRND"/>
    <dbReference type="OrthoDB" id="338684at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1454" mass="171109" checksum="5E11E1CF8E0DA1C3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYW8</accession>
    <name>Q5CYW8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628262.1">
        <property type="nucleotide sequence ID" value="XM_628260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYW8"/>
    <dbReference type="GeneID" id="3372015"/>
    <dbReference type="KEGG" id="cpv:cgd7_730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_730"/>
    <dbReference type="InParanoid" id="Q5CYW8"/>
    <dbReference type="OrthoDB" id="337676at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="146" mass="17490" checksum="D0860965288E3B3F" modified="2005-04-12" version="1">MDISCMILNEDFTGIQQNTLDKYLEVYKQFLDLIPNNFHEHIEIDDILKNIKSINQECIPQSNITKTKFNILTRNISKKYFGDWRQVDSENLCVGTEKKSNNYIFKPEKEYNIENVLKKRFLFWIINNYENQRIPNLNSFNQDSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYX3</accession>
    <name>Q5CYX3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">t-SNARE domain followed by hydrophobic stretch</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_670</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628257.1">
        <property type="nucleotide sequence ID" value="XM_628255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYX3"/>
    <dbReference type="STRING" id="353152.Q5CYX3"/>
    <dbReference type="GeneID" id="3372011"/>
    <dbReference type="KEGG" id="cpv:cgd7_670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_670"/>
    <dbReference type="InParanoid" id="Q5CYX3"/>
    <dbReference type="OMA" id="DWEIKFA"/>
    <dbReference type="OrthoDB" id="75754at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15840">
        <property type="entry name" value="SNARE_Qa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="289"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="4">
        <location>
            <begin position="213"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="34"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="311" mass="36414" checksum="1E8C7C3A310C4322" modified="2005-04-12" version="1">MVFEIQIHDGEGENEEEEEEELSYFVSDTQRDWAESHERRIAKLFQQLEEKQVQLEEKISESQGISKVSHDLCKKVDQIFKKIEQLNQNINDVLRSWRIELAGNPLEYREQKNILENYLARQKVALDTIGYLSRKVEDLKSRQTTIESNSYSNHFDRFTGYETDNRNNNYGYRLPHEDSSYEVQIEDDNFRQQQSHYKPPTLYTHQTFDMVDRQIAQETAIGLGHIQSQMYEANQIFKNLASMVNEQGETIQNLETTIDNTVYTAKQAVGELRKAYNSSSYKFSLIANYGLPGFLLLILALILTLYFLHVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPM3</accession>
    <name>A3FPM3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">N-acetylglucosaminylphosphatidylinositol deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.89</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PIGL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.89" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388369.1">
        <property type="nucleotide sequence ID" value="XM_001388332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPM3"/>
    <dbReference type="FunCoup" id="A3FPM3">
        <property type="interactions" value="262"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPM3"/>
    <dbReference type="GeneID" id="3371868"/>
    <dbReference type="KEGG" id="cpv:cgd7_700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_700"/>
    <dbReference type="InParanoid" id="A3FPM3"/>
    <dbReference type="OMA" id="SGETHNK"/>
    <dbReference type="OrthoDB" id="440160at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000225">
        <property type="term" value="F:N-acetylglucosaminylphosphatidylinositol deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10320">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003737">
        <property type="entry name" value="GlcNAc_PI_deacetylase-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024078">
        <property type="entry name" value="LmbE-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993:SF11">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12993">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL DE-N-ACETYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02585">
        <property type="entry name" value="PIG-L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102588">
        <property type="entry name" value="LmbE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="146"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="175" mass="20316" checksum="7057C3DA4A40003F" modified="2007-04-03" version="1">MTIFENQKNVCVLVAHPDDEAMFFTPIIKQVCGEGNKVYVLCLTNGDYYGLGKLREKELLEACNALGILRDRIRVVSNDKFQDQPNEKWPYTDVISEIESFVDEFNIDIILTFDEFGISGHINHISTNESVKEWIQGSKREKYPKVYVLETSNIFIKYSGILSLLYLYIFPKNEW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPN6</accession>
    <name>A3FPN6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">RuvB-like helicase</fullName>
            <ecNumber evidence="8">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_2090</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388382.1">
        <property type="nucleotide sequence ID" value="XM_001388345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPN6"/>
    <dbReference type="SMR" id="A3FPN6"/>
    <dbReference type="FunCoup" id="A3FPN6">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPN6"/>
    <dbReference type="GeneID" id="3371824"/>
    <dbReference type="KEGG" id="cpv:cgd7_2090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2090"/>
    <dbReference type="InParanoid" id="A3FPN6"/>
    <dbReference type="OMA" id="RTLPYNK"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000001">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="64"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="457" mass="50146" checksum="05649F3D84E3A101" modified="2007-04-03" version="1">MNIEGEKPSSTNFSRVSTHSHIRGLGLKNDGTASNDGSCGMIGQLQARESAGVVLSLIQNKKLAGKAVLLAGPPGTGKTAIAQAIAHELGPKVPFCPMVASEVYSAEVKKTEILMENFRRAIGLRIRDVKEVYEGEVVELVTEETENPHGNFGKAVSAIVLTLKSAKGTKTLRLAPQLSDVFQKEKVKVGDIIYVESSSGIVKRLGRSDSFATEFDLESEEYVPLPKGDVYKKREIVQDITLYDLDLANAKPQGGQDIISLLGQYVRPKKTEITEKLRLEVNKSVNEYIDQGVAELVPGVLFIDEVHMLDIECFTFLNRTLESSLAPIVIFGTNRGVCTVRGTDMLSSHGIPVDLLDRLLIIRTIPYNIEEMIRIVSIRCDIEGIKMDKESLQLIGEIGSSTSLRYICQLLTPAHIIASTFGRDTICKSDIQEVDSLFFDSNASARRLAEDSNSFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPP4</accession>
    <name>A3FPP4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme E2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_2800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388390.1">
        <property type="nucleotide sequence ID" value="XM_001388353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPP4"/>
    <dbReference type="FunCoup" id="A3FPP4">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPP4"/>
    <dbReference type="GeneID" id="3371832"/>
    <dbReference type="KEGG" id="cpv:cgd7_2800"/>
    <dbReference type="InParanoid" id="A3FPP4"/>
    <dbReference type="OMA" id="MRWKAFI"/>
    <dbReference type="OrthoDB" id="9973183at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23812">
        <property type="entry name" value="UBCc_ScPEX4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="137" mass="15663" checksum="27A9B78A8506F76E" modified="2007-04-03" version="1" fragment="single">ETIINTYFFSRENDLMYWDGEIVGPDETPYEGFVFKIEIIVSPQYPILPPSVKFVTPIFHPNVNFFTGEVCIDVIKDNWTPAWTLHAVCRAIISILCDPNPNSPLNCDAGNILRCGDKKGFNNMARMYSLEYASKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPT4</accession>
    <name>A3FPT4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Calcium load-activated calcium channel</fullName>
            <shortName evidence="14">CLAC channel</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd6_1490</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Calcium-selective channel required to prevent calcium stores from overfilling.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the TMCO1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388313.1">
        <property type="nucleotide sequence ID" value="XM_001388276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPT4"/>
    <dbReference type="FunCoup" id="A3FPT4">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPT4"/>
    <dbReference type="GeneID" id="3375938"/>
    <dbReference type="KEGG" id="cpv:cgd6_1490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1490"/>
    <dbReference type="InParanoid" id="A3FPT4"/>
    <dbReference type="OMA" id="GMFGDFK"/>
    <dbReference type="OrthoDB" id="342726at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002809">
        <property type="entry name" value="EMC3/TMCO1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008559">
        <property type="entry name" value="TMCO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20917:SF0">
        <property type="entry name" value="CALCIUM LOAD-ACTIVATED CALCIUM CHANNEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20917">
        <property type="entry name" value="PNAS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01956">
        <property type="entry name" value="EMC3_TMCO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF023322">
        <property type="entry name" value="DUF841_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01415">
        <property type="entry name" value="DUF106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0106">Calcium</keyword>
    <keyword evidence="5 14" id="KW-0107">Calcium channel</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 14" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="13" id="KW-0407">Ion channel</keyword>
    <keyword evidence="11 14" id="KW-0406">Ion transport</keyword>
    <keyword evidence="12 14 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="17"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006537"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRNR" id="PIRNR023322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAZ51507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="195" mass="22013" checksum="5961382350612A9C" modified="2007-04-03" version="1">MSEAELNPYIEFNKYKVLIVIFSALLASIAAELLSYFLFFRKNDFIKMQDNLIKSRAKLDKLKLKDKTGIITENTTLSSSYSNKIKKNPKIESLEQSITNLTYKISMIKMKSGILVGILFAALIPLKNTFFGDLPICKLPFEPIKIFRLVTQAGLKNASVDDAGSIFIFGQAFMAFRMAIQKAVYFDTSSSFGRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPV7</accession>
    <name>A3FPV7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_3400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388336.1">
        <property type="nucleotide sequence ID" value="XM_001388299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPV7"/>
    <dbReference type="STRING" id="353152.A3FPV7"/>
    <dbReference type="GeneID" id="3375961"/>
    <dbReference type="KEGG" id="cpv:cgd6_3400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3400"/>
    <dbReference type="InParanoid" id="A3FPV7"/>
    <dbReference type="OMA" id="STIMEIN"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24347">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="23"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="522"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="781"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="781"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="797"/>
            <end position="808"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="979" mass="110169" checksum="50E32D9D2D9CE568" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ38</accession>
    <name>A3FQ38_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="2 10">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd3_3030</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="2 10"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388118.1">
        <property type="nucleotide sequence ID" value="XM_001388081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ38"/>
    <dbReference type="STRING" id="353152.A3FQ38"/>
    <dbReference type="GeneID" id="3374069"/>
    <dbReference type="KEGG" id="cpv:cgd3_3030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3030"/>
    <dbReference type="InParanoid" id="A3FQ38"/>
    <dbReference type="OMA" id="NRYTDLN"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07834">
        <property type="entry name" value="STKc_MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000040">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000028">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="566" mass="64306" checksum="5E2A5E5A53E33D13" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ45</accession>
    <name>A3FQ45_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">BTB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_3600</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388125.1">
        <property type="nucleotide sequence ID" value="XM_001388088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ45"/>
    <dbReference type="SMR" id="A3FQ45"/>
    <dbReference type="STRING" id="353152.A3FQ45"/>
    <dbReference type="GeneID" id="3373821"/>
    <dbReference type="KEGG" id="cpv:cgd3_3600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3600"/>
    <dbReference type="InParanoid" id="A3FQ45"/>
    <dbReference type="OMA" id="YKEAIYV"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd14733">
        <property type="entry name" value="BACK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.420">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF3">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BTB" evidence="3">
        <location>
            <begin position="363"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="526" mass="59951" checksum="F3E9589658FFCAC3" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ46</accession>
    <name>A3FQ46_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd3_3690</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388126.1">
        <property type="nucleotide sequence ID" value="XM_001388089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ46"/>
    <dbReference type="STRING" id="353152.A3FQ46"/>
    <dbReference type="GeneID" id="3373820"/>
    <dbReference type="KEGG" id="cpv:cgd3_3690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3690"/>
    <dbReference type="InParanoid" id="A3FQ46"/>
    <dbReference type="OMA" id="IFINYKR"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17945">
        <property type="entry name" value="DEADc_DDX23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="173"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="368"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="529" mass="60022" checksum="130B80ACD8124097" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ66</accession>
    <name>A3FQ66_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase domain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_1610</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388202.1">
        <property type="nucleotide sequence ID" value="XM_001388165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ66"/>
    <dbReference type="STRING" id="353152.A3FQ66"/>
    <dbReference type="GeneID" id="3373453"/>
    <dbReference type="KEGG" id="cpv:cgd2_1610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1610"/>
    <dbReference type="InParanoid" id="A3FQ66"/>
    <dbReference type="OMA" id="TRINCCI"/>
    <dbReference type="OrthoDB" id="5794026at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF18">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="130"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="516" mass="59327" checksum="96DADF337AC67509" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ67</accession>
    <name>A3FQ67_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cytidine and deoxycytidylate deaminase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_1630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388203.1">
        <property type="nucleotide sequence ID" value="XM_001388166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ67"/>
    <dbReference type="FunCoup" id="A3FQ67">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ67"/>
    <dbReference type="GeneID" id="3373452"/>
    <dbReference type="KEGG" id="cpv:cgd2_1630"/>
    <dbReference type="InParanoid" id="A3FQ67"/>
    <dbReference type="OMA" id="VGCVIVM"/>
    <dbReference type="OrthoDB" id="1701769at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002100">
        <property type="term" value="P:tRNA wobble adenosine to inosine editing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01285">
        <property type="entry name" value="nucleoside_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF149">
        <property type="entry name" value="TRNA-SPECIFIC ADENOSINE DEAMINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="2">
        <location>
            <begin position="1"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="186" mass="21049" checksum="77794159CFCFFA47" modified="2007-04-03" version="1" fragment="single">SEFAVKSNEVPVGCVIVNRTTKEIESEAHNETNISRNGTRHCEIVALEKLIVKLKSTSGKINNSTRLITQNQDEYSNTRFRINLGDIYDLFVTVEPCIMCIGFIDQMGIHNIFYGCKNYRFGGCGSVLDYHHLNKSSKIILTSGICENESIKILKEFYEIGNPKAPENKRKRPLKALNCTLPLYKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ74</accession>
    <name>A3FQ74_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Guanine nucleotide-binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_1870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388210.1">
        <property type="nucleotide sequence ID" value="XM_001388173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ74"/>
    <dbReference type="SMR" id="A3FQ74"/>
    <dbReference type="FunCoup" id="A3FQ74">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ74"/>
    <dbReference type="GeneID" id="3373445"/>
    <dbReference type="KEGG" id="cpv:cgd2_1870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1870"/>
    <dbReference type="InParanoid" id="A3FQ74"/>
    <dbReference type="OMA" id="NCKLKIN"/>
    <dbReference type="OrthoDB" id="7875889at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045182">
        <property type="term" value="F:translation regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000018">
        <property type="entry name" value="Receptor for activated C kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045223">
        <property type="entry name" value="RACK1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19868">
        <property type="entry name" value="RECEPTOR FOR ACTIVATED PROTEIN KINASE C RACK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="11"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="62"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="104"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="147"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="190"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="287"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="313" mass="34082" checksum="39804CCE94379E02" modified="2007-04-03" version="1">MESSLEYIGCLSGHSDWVTSIAAPPDNSDIVVSASRDKSVLVWNLSDANKDQHSIGSAKTRLTGHNQAVNDVAVSSDGSYVVSGSCDKTLRLFDVNAGKSVRNFVGHTSDVFSVALSPDNRQIISGSRDHTIKVWNAMGVCMYTLLDGQHNDWVSCVRFSPSTSQPLFVSCGWDKIVKVWSHEFKPTCNLVGHSSVLYTVTIAPDGSLCASGGKDGVVMLWDVSEGKHLYSLDANHSINALCFSPCNYWLCAATDKCIRIWELEHKLPVAEFAPPAPIKNGLPWCVSLTWSNDGKTLFAGSTDSNIYVYKVKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ97</accession>
    <name>A3FQ97_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DnaJ homolog subfamily C member 10</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">DnaJ homolog subfamily C member 16</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Endoplasmic reticulum DNA J domain-containing protein 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd2_3230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Plays an important role in regulating the size of autophagosomes during the formation process.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388233.1">
        <property type="nucleotide sequence ID" value="XM_001388196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ97"/>
    <dbReference type="SMR" id="A3FQ97"/>
    <dbReference type="STRING" id="353152.A3FQ97"/>
    <dbReference type="GeneID" id="3373541"/>
    <dbReference type="KEGG" id="cpv:cgd2_3230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3230"/>
    <dbReference type="InParanoid" id="A3FQ97"/>
    <dbReference type="OMA" id="FFISYND"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052842">
        <property type="entry name" value="ER_Co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45184">
        <property type="entry name" value="DNAJ PROTEIN ERDJ3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45184:SF1">
        <property type="entry name" value="DNAJ PROTEIN ERDJ3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0072">Autophagy</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002652586" description="DnaJ homolog subfamily C member 10" evidence="8">
        <location>
            <begin position="22"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="23"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="10">
        <location>
            <begin position="164"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="555"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="147"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="577"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="601" mass="67321" checksum="CA69CEDA7DB9960F" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQF4</accession>
    <name>A3FQF4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Sm protein B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd1_2910</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP SmB/SmN family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388176.1">
        <property type="nucleotide sequence ID" value="XM_001388139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQF4"/>
    <dbReference type="STRING" id="353152.A3FQF4"/>
    <dbReference type="GeneID" id="3371393"/>
    <dbReference type="KEGG" id="cpv:cgd1_2910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2910"/>
    <dbReference type="InParanoid" id="A3FQF4"/>
    <dbReference type="OMA" id="RHMNMVI"/>
    <dbReference type="OrthoDB" id="2020720at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070990">
        <property type="term" value="F:snRNP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01717">
        <property type="entry name" value="Sm_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050914">
        <property type="entry name" value="snRNP_SmB/NAA38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10701">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN-ASSOCIATED PROTEIN B AND N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="1"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="139" mass="15409" checksum="0FF486A472ED4A37" modified="2007-04-03" version="1">MQKYINYRIRVTVQDDRVMVGNLMAFDRHMNLVLSDCQEYRRVKKGEESKELKRSLGLIMLRGENIVTFVAEAPPKNQSTKPVEPTFAGNIQTIARGPPLIPPPMIPPGQFPLINPSIGGLPIPPPGVPPLPPNIHGNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQI1</accession>
    <name>A3FQI1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Ribosomal protein L3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_1580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388265.1">
        <property type="nucleotide sequence ID" value="XM_001388228.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQI1"/>
    <dbReference type="FunCoup" id="A3FQI1">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQI1"/>
    <dbReference type="GeneID" id="3373361"/>
    <dbReference type="KEGG" id="cpv:cgd5_1580"/>
    <dbReference type="InParanoid" id="A3FQI1"/>
    <dbReference type="OMA" id="QRTEYNK"/>
    <dbReference type="OrthoDB" id="1611972at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1430.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000351">
        <property type="entry name" value="Ribosomal protein L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1430.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045077">
        <property type="entry name" value="L3_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000597">
        <property type="entry name" value="Ribosomal_uL3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019926">
        <property type="entry name" value="Ribosomal_uL3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11363:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00297">
        <property type="entry name" value="Ribosomal_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00474">
        <property type="entry name" value="RIBOSOMAL_L3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="305" mass="34508" checksum="2079A262CBC0D24D" modified="2007-04-03" version="1">MICVGFVGYIETPNGLRALTTVFAGYLSEECKRRFYKNYYRSKRKAFTKYARNYAENQRMEAEIARCKQYCTVIRALCHTQVSKTGLNKKKADIMEIQVNGGTVSDKIDFCVRCFEQPIPVSTIFNENEMIDIIGISKGKGYKGVISRWGVTKLPRKTRRGVRKVSCIGAWHPARVQFQVPRAGQKGYGQRTETNKKIYRIGRGDDPRNASTSADLTEKTITPMGGFPRYGVVNQDFLMLKGCTVGCKKRLLTLRKSLVPPVTRSALEVVNLKFIDTSSKFGHGRFQTSAEKAKYYGPCKRSIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQL9</accession>
    <name>A3FQL9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-directed RNA polymerases I, II, and III subunit RPABC5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_3260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388074.1">
        <property type="nucleotide sequence ID" value="XM_001388037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQL9"/>
    <dbReference type="FunCoup" id="A3FQL9">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQL9"/>
    <dbReference type="GeneID" id="3372816"/>
    <dbReference type="KEGG" id="cpv:cgd4_3260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3260"/>
    <dbReference type="InParanoid" id="A3FQL9"/>
    <dbReference type="OMA" id="MCHVDLI"/>
    <dbReference type="OrthoDB" id="10258858at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000024">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00250">
        <property type="entry name" value="RNApol_arch_Rpo10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023580">
        <property type="entry name" value="RNA_pol_su_RPB10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020789">
        <property type="entry name" value="RNA_pol_suN_Zn-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000268">
        <property type="entry name" value="RPABC5/Rpb10"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003089">
        <property type="entry name" value="PRK04016.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431:SF3">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23431">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01194">
        <property type="entry name" value="RNA_pol_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005653">
        <property type="entry name" value="RNA_pol_N/8_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46924">
        <property type="entry name" value="RNA polymerase subunit RPB10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01112">
        <property type="entry name" value="RNA_POL_N_8KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="72" mass="8473" checksum="442477DB534A5275" modified="2007-04-03" version="1" fragment="single">MIIPVRCFTCGKVIGNLWQPWLVLLQNNVPEGEALDKLGLRRYCCRRMILTHADLIEKLMAYNIHERKTMMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQQ1</accession>
    <name>A3FQQ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin-conjugating enzyme E2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAZ51225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388420.1">
        <property type="nucleotide sequence ID" value="XM_001388383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQQ1"/>
    <dbReference type="FunCoup" id="A3FQQ1">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQQ1"/>
    <dbReference type="GeneID" id="3372483"/>
    <dbReference type="KEGG" id="cpv:cgd8_580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_580"/>
    <dbReference type="InParanoid" id="A3FQQ1"/>
    <dbReference type="OMA" id="GPESCSY"/>
    <dbReference type="OrthoDB" id="6508832at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd23807">
        <property type="entry name" value="UEV_UBE2V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000026">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="2">
        <location>
            <begin position="7"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="140" mass="15783" checksum="6F202BCA0548F47C" modified="2007-04-03" version="1" fragment="single">MDEVIVPRSFRLLDELERGQKGQATDGVSWGLDQHDDITLSTWACTIFGPPNTTFENRIYSLTVSCGPNYPDEAPIVKFNTKISLGCVDGHGFVSPSFAVLKQWQRNFYIENVLIALRHEMASNSNRRLAQPPEGTFYDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQQ8</accession>
    <name>A3FQQ8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ABC transporter family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd4_4440</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAZ51220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388087.1">
        <property type="nucleotide sequence ID" value="XM_001388050.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQQ8"/>
    <dbReference type="GeneID" id="3372409"/>
    <dbReference type="KEGG" id="cpv:cgd4_4440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4440"/>
    <dbReference type="InParanoid" id="A3FQQ8"/>
    <dbReference type="OMA" id="FAWLQVF"/>
    <dbReference type="OrthoDB" id="4865934at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="92"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="239"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="750"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="794"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="894"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="980"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1021"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="444"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="795"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1091"/>
            <end position="1343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1344" mass="156554" checksum="6DF816D076D28405" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPN0</accession>
    <name>Q5CPN0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor TFIIF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625391.1">
        <property type="nucleotide sequence ID" value="XM_625391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPN0"/>
    <dbReference type="STRING" id="353152.Q5CPN0"/>
    <dbReference type="GeneID" id="3372364"/>
    <dbReference type="KEGG" id="cpv:cgd2_220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_220"/>
    <dbReference type="InParanoid" id="Q5CPN0"/>
    <dbReference type="OrthoDB" id="16041at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16910">
        <property type="entry name" value="YEATS_TFIID14_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1970">
        <property type="entry name" value="YEATS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038704">
        <property type="entry name" value="YEAST_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005033">
        <property type="entry name" value="YEATS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055129">
        <property type="entry name" value="YEATS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47573:SF1">
        <property type="entry name" value="PROTEIN AF-9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03366">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51037">
        <property type="entry name" value="YEATS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="YEATS" evidence="6">
        <location>
            <begin position="25"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="258"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="430"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="258"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="430"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="462"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="472" mass="53922" checksum="99CBD9CF55DD7627" modified="2005-04-12" version="1">MADTSSRVKTSSSSVTAMSSIENRRRKNVTIRKPIILGTYAFMLSIAEQKKRGDNATHSWTCFLRSPDNEDISYYVKKVVFSLHPSFLNPNRVVEKCPFEVTECGWGEFDIMAKVYFVDSTEKPVEIKHFLRLYPPGTTDVRSVKFPSDNTPSDCVASETYDEFIFYEPTEKFYEKLISGPIQPMAQHRLQPYFHKTDKSAFEKTLAAAHVSIQNEMASLRAEIAQITLDIQNIRENYYSLRPSEVASMFPQQHIADQSPISESKSSHMMHQQSELSLPPGGPIIQKSELYGRSSPNQRTQNSKFQGLPNSRPDCTVDPQFQPQNIDHINHYDSGNIAQASGQQFHQNFQQQQQHQQHHQVHHNMTDIPPHQIHQGHSSHQNIYDNPKMVSHLAHNHNSNSNFKPNNSLDGVNIDINRQTQFQMTNQIQTNRNPENPHSVINNNQGQYSTHDPNLPPKMEPHSSNPNNANIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPN8</accession>
    <name>Q5CPN8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosome associated membrane protein RAMP4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_140</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RAMP4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625383.1">
        <property type="nucleotide sequence ID" value="XM_625383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPN8"/>
    <dbReference type="FunCoup" id="Q5CPN8">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPN8"/>
    <dbReference type="GeneID" id="3372355"/>
    <dbReference type="KEGG" id="cpv:cgd2_140"/>
    <dbReference type="InParanoid" id="Q5CPN8"/>
    <dbReference type="OMA" id="KYATTPW"/>
    <dbReference type="OrthoDB" id="16679at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010580">
        <property type="entry name" value="ER_stress-assoc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15601:SF0">
        <property type="entry name" value="GEO09675P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15601">
        <property type="entry name" value="STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06624">
        <property type="entry name" value="RAMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="10">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="65" mass="7090" checksum="0C221380E3CDF4E8" modified="2005-04-12" version="1">MAQSRFTKLKGELYEKNIDKRGSVSSSKKKSGYPVGPFALGLFIFVVIGSAIIQMIVSATTKHLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPV1</accession>
    <name>Q5CPV1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DinB/family X-type DNA polymerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_3920</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625413.1">
        <property type="nucleotide sequence ID" value="XM_625413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPV1"/>
    <dbReference type="STRING" id="353152.Q5CPV1"/>
    <dbReference type="GeneID" id="3372429"/>
    <dbReference type="KEGG" id="cpv:cgd4_3920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3920"/>
    <dbReference type="InParanoid" id="Q5CPV1"/>
    <dbReference type="OMA" id="WFTRSDA"/>
    <dbReference type="OrthoDB" id="447129at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009314">
        <property type="term" value="P:response to radiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052230">
        <property type="entry name" value="DNA_polymerase_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043128">
        <property type="entry name" value="Rev_trsase/Diguanyl_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001126">
        <property type="entry name" value="UmuC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45873:SF1">
        <property type="entry name" value="DNA POLYMERASE ETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00817">
        <property type="entry name" value="IMS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50173">
        <property type="entry name" value="UMUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="UmuC" evidence="7">
        <location>
            <begin position="37"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="358" mass="42006" checksum="8E56918ADA64D685" modified="2005-04-12" version="1">MLNFYELKKSKQLDYSYKDIADDFVNKFNEKMVPRIISLIDMDAFFAQVCHVEYNIPRDKPLAVINNNVVLAVNYPSREKGVNRKMSKEEILSICPEIIIPQNVFLDARGQYLELFNDDNLNMTYQKLSLDIFRKASKMVFTKLKSYLPTCNAQIASIDEIYFDLTNIIQKIFNSIKNYLSNHNHPNFDFDKLKSEICINSINTNILLTRNACNNNLFDFNKIIEILFPEILDEKIMSNIINYDIFNSKDIDNNINYYHLTFQEMCLIFGSILIYRARKRLQEETTYTCSSGIFINKIYSKMISSLKKPNGQTVLLHRWFESYIKDTHILKLRFLGGKLGKCLIEKFPEIQSIKDLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ43</accession>
    <name>Q5CQ43_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd5_4210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625583.1">
        <property type="nucleotide sequence ID" value="XM_625583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ43"/>
    <dbReference type="FunCoup" id="Q5CQ43">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ43"/>
    <dbReference type="MEROPS" id="T01.012"/>
    <dbReference type="GeneID" id="3372567"/>
    <dbReference type="KEGG" id="cpv:cgd5_4210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4210"/>
    <dbReference type="InParanoid" id="Q5CQ43"/>
    <dbReference type="OMA" id="NLGMAMQ"/>
    <dbReference type="OrthoDB" id="37597at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03761">
        <property type="entry name" value="proteasome_beta_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000051">
        <property type="entry name" value="Proteasome subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF3">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 10 11" id="KW-0647">Proteasome</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <keyword evidence="7" id="KW-0865">Zymogen</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="290" mass="32523" checksum="F237FF5914D53A81" modified="2005-04-12" version="1">MTFDFLDSGIEAINHYGIRNENLKNSGFLRLDFFGNDKDEEDFVERIYEETFQYAKIENPCKFVSEYNKGEIRKMMNRGTTTLGFIYQGGVILAVDSRASQGSYIASQEVKKIIQINDFLLGTMAGGAADCSYWERVLSKLCRLYELRNGERISVAGASKMITNIFFHYRAYDLSAGIMIAGFDKDGPHLYYVDNEGSRVKDCKFSVGSGSLYAYGVLDSGYRYDLTDEEAIDLGKRAIVIATNRDGGSGGLVRVYQINKNGVIKHVPGEDVSELHYAYSKKQGTDPTKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ61</accession>
    <name>Q5CQ61_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_4010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625565.1">
        <property type="nucleotide sequence ID" value="XM_625565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ61"/>
    <dbReference type="GeneID" id="3372517"/>
    <dbReference type="KEGG" id="cpv:cgd5_4010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4010"/>
    <dbReference type="InParanoid" id="Q5CQ61"/>
    <dbReference type="OrthoDB" id="343781at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030119">
        <property type="term" value="C:AP-type membrane coat adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038741">
        <property type="entry name" value="AP5B1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34033">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34033:SF1">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="413" mass="49100" checksum="2A8CA377F66AF206" modified="2005-04-12" version="1">MNNYNVIYLLNNLFGYIKSQLKVYDTQLLDSINEIECSMNCMSLRTIHGLFEIEEYKQCKENLNNLEHISKQRESKLEERLQTENVNKELYKIRLDAYKQFRRQIYGLRDDSFSIFSKNKQHNTLILPFQIKYLEIDEEQSCLYGIKLNFKSSNDSLGIDPVYIPFLKPQNIQELEKEDIEEMVISKYLEEENSRVINLNNNIVFLLLIVKVKFPIPGKLQIDMEFNDKFGQTIYDKLDSIQISFQDYFLPSPNEDWILKCYKALSLRPLELESETSKHKSQLETPEMVNTCKLLDISSNLVLRNINKHLRTFEINGNELLSVINEKINIKEDFDFKHDLLIHQIELKKQNFIEDLQVQISYRWFCIHLLPKYYLIIQFSITNKSSIVRIYTDFPEILSHCDDFFDSWLSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ72</accession>
    <name>Q5CQ72_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein with RING finger domain at C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_3900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625554.1">
        <property type="nucleotide sequence ID" value="XM_625554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ72"/>
    <dbReference type="GeneID" id="3372597"/>
    <dbReference type="KEGG" id="cpv:cgd5_3900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3900"/>
    <dbReference type="InParanoid" id="Q5CQ72"/>
    <dbReference type="OMA" id="INEPWIS"/>
    <dbReference type="OrthoDB" id="338829at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1052" mass="125446" checksum="F57EE7553590C304" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQA6</accession>
    <name>Q5CQA6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_1460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625742.1">
        <property type="nucleotide sequence ID" value="XM_625742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQA6"/>
    <dbReference type="GeneID" id="3372708"/>
    <dbReference type="KEGG" id="cpv:cgd4_1460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1460"/>
    <dbReference type="InParanoid" id="Q5CQA6"/>
    <dbReference type="OMA" id="HNDERMK"/>
    <dbReference type="OrthoDB" id="343020at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="79"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="141" mass="16568" checksum="96F35D8A575C1D92" modified="2005-04-12" version="1">MKEKIETLHTVITEKLGSELLSKALYILFLLKLVMLIGFGSYYFNKRKQEKAKQLNDMRMRKIRENQIKVWEKDISEYTSANSKNESSLEEDQKEENKQKKKSKLSWMSANSNSHLNPHFSHLSTYKPSVSKRYPCKKCCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQB4</accession>
    <name>Q5CQB4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter with two AAA domains and 14 transmembrane regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_1380</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="project" value="UniProtKB-SubCell"/>
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        <property type="project" value="InterPro"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="102"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="375"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="755"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="793"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="827"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="855"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="934"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="959"/>
            <end position="981"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1052"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1080"/>
            <end position="1101"/>
        </location>
    </feature>
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        <location>
            <begin position="1147"/>
            <end position="1476"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1479" mass="168592" checksum="1FE1A628718BA1EA" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQC1</accession>
    <name>Q5CQC1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative secreted protein with thr rich regions, possible mucin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_1300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
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            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_625727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQC1"/>
    <dbReference type="STRING" id="353152.Q5CQC1"/>
    <dbReference type="GeneID" id="3372617"/>
    <dbReference type="KEGG" id="cpv:cgd4_1300"/>
    <dbReference type="InParanoid" id="Q5CQC1"/>
    <dbReference type="OMA" id="NTMAIAN"/>
    <dbReference type="OrthoDB" id="344331at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254113" evidence="3">
        <location>
            <begin position="27"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="127"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="217"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="564" mass="56235" checksum="61315915ECC59B3A" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQR6</accession>
    <name>Q5CQR6_CRYPI</name>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_3600</name>
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    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
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            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625936.1">
        <property type="nucleotide sequence ID" value="XM_625936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQR6"/>
    <dbReference type="GeneID" id="3372812"/>
    <dbReference type="KEGG" id="cpv:cgd4_3600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3600"/>
    <dbReference type="InParanoid" id="Q5CQR6"/>
    <dbReference type="OMA" id="CISFEAY"/>
    <dbReference type="OrthoDB" id="337106at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="992" mass="116195" checksum="5D19998B674DF18D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQT2</accession>
    <name>Q5CQT2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625920.1">
        <property type="nucleotide sequence ID" value="XM_625920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQT2"/>
    <dbReference type="GeneID" id="3372867"/>
    <dbReference type="KEGG" id="cpv:cgd4_3440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3440"/>
    <dbReference type="InParanoid" id="Q5CQT2"/>
    <dbReference type="OMA" id="EMMSTEY"/>
    <dbReference type="OrthoDB" id="341888at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="795" mass="92969" checksum="B5F922DA7A5596CA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQT7</accession>
    <name>Q5CQT7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_3380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87787.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625915.1">
        <property type="nucleotide sequence ID" value="XM_625915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQT7"/>
    <dbReference type="FunCoup" id="Q5CQT7">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="GeneID" id="3372872"/>
    <dbReference type="KEGG" id="cpv:cgd4_3380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3380"/>
    <dbReference type="InParanoid" id="Q5CQT7"/>
    <dbReference type="OMA" id="IPLYMKC"/>
    <dbReference type="OrthoDB" id="328505at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87787.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="248" mass="28506" checksum="268EFE684060701F" modified="2005-04-12" version="1">MNNKIRDNVNSRSVKITVPDSSLRRTDTEVRELVIALKERIFLDHELVSRLRYFWPTNELQEQLLFSICKDVPRNDSPLEDASHFKLQFMMDPSKYGGAFNDCCEWLGPINKFNYCPAVKVHLPNTYEPWITYTSNVLAYLFGKIPGCDSPSSFLKMSTIRVNEPFQMSCGNRKCIRISHIVYKEGMKGYSISERVNPYPDYVDIDEALKPSLEAIDVNGLNESYSQNNQNAYQGSPPKESVVAQLHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR14</accession>
    <name>Q5CR14_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625838.1">
        <property type="nucleotide sequence ID" value="XM_625838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR14"/>
    <dbReference type="GeneID" id="3372877"/>
    <dbReference type="KEGG" id="cpv:cgd4_2500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2500"/>
    <dbReference type="InParanoid" id="Q5CR14"/>
    <dbReference type="OrthoDB" id="343180at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254137" evidence="1">
        <location>
            <begin position="23"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="167" mass="19333" checksum="13CEB5CA178C1500" modified="2005-04-12" version="1">MTKFKLAYLYLFFLLVFTATDAFNPIGNIIMSSIGFFNPLLRVFKSFYSMEKNSSSKIRYNYIKHLGYEHLQSASNQEVGSSINHVESRKLKKKLFFFHEETANTTLNITDNNKILNDTSQKQILNLIQNFTNETNTFGDLTPRVNRSNTLRLINRTNSILNADENT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR17</accession>
    <name>Q5CR17_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625835.1">
        <property type="nucleotide sequence ID" value="XM_625835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR17"/>
    <dbReference type="GeneID" id="3372878"/>
    <dbReference type="KEGG" id="cpv:cgd4_2470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2470"/>
    <dbReference type="InParanoid" id="Q5CR17"/>
    <dbReference type="OMA" id="WEMANTQ"/>
    <dbReference type="OrthoDB" id="343419at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254425" evidence="1">
        <location>
            <begin position="21"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="844" mass="95803" checksum="17C7249C0A505E7B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR57</accession>
    <name>Q5CR57_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cell division control protein 73 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_2010</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC73 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625795.1">
        <property type="nucleotide sequence ID" value="XM_625795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR57"/>
    <dbReference type="STRING" id="353152.Q5CR57"/>
    <dbReference type="GeneID" id="3372963"/>
    <dbReference type="KEGG" id="cpv:cgd4_2010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2010"/>
    <dbReference type="InParanoid" id="Q5CR57"/>
    <dbReference type="OMA" id="ICCKYRK"/>
    <dbReference type="OrthoDB" id="2186602at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11990">
        <property type="entry name" value="RNA polymerase II accessory factor, Cdc73 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007852">
        <property type="entry name" value="Cdc73/Parafibromin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031336">
        <property type="entry name" value="CDC73_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038103">
        <property type="entry name" value="CDC73_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466">
        <property type="entry name" value="CDC73 DOMAIN PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12466:SF8">
        <property type="entry name" value="PARAFIBROMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05179">
        <property type="entry name" value="CDC73_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Cell division control protein 73 C-terminal" evidence="6">
        <location>
            <begin position="308"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="235"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="252"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05179"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="476" mass="55037" checksum="05FA9E82A5C8C539" modified="2005-04-12" version="1">MSEDDQLQAFVDPLILLKDTITRGKTDEIIKLGDEFHFEFYNCSLNVNTPTRCRNRRGESLNLDDLYLFITASKSKKYTMKLAQDNGLKFINILEKKNILEFLNEFIEKTQDSRIPSTYSIEDLGKYECINTEFSLQPCRILDKSKKILNLNYPWVEYKVKTDIESINGKSSENIIHSKVANSIQLKNRDEIMFVKRKVNLISQIYPINIDYICQGIDMYTRINSLLTFMNEPAKSENKKRSAESSSYIHNAENKKLKDGRRSNTADFGKRGSESLISTSNISKSRNIPKSINSQQRSTLLAYLNSNNLNPIILVPPSSKSPITLNNIIQFLRDKEFVDPNLAKRNFAGNEQTVTLSFGSGTTVQKVTFRILESTLNFRKRDWYSLIAVFLTGAEWQLQSFPFKTIQDIFTMVKGYHITYDSEPIPDNIRKWNVDVVRINRTNRHNDLSVWFQFMESIESVLASSRDHSKLDRSKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR68</accession>
    <name>Q5CR68_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_1900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625784.1">
        <property type="nucleotide sequence ID" value="XM_625784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR68"/>
    <dbReference type="FunCoup" id="Q5CR68">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="GeneID" id="3372895"/>
    <dbReference type="KEGG" id="cpv:cgd4_1900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1900"/>
    <dbReference type="InParanoid" id="Q5CR68"/>
    <dbReference type="OrthoDB" id="546861at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="143" mass="17182" checksum="D7A4A89D8A4C3E30" modified="2005-04-12" version="1">MYKLLDNIINNVKNNPEKFIEINRDEINSREKKLKDKYEIMINCKEEARLTYSHAKEKEIQNQRRINRDFLLNSHATINNYNLEHEFHNIEISNKDENLEYIHQNTKKLHSAALIISQELNEQNNLIEGMIYQVEEESKLLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR69</accession>
    <name>Q5CR69_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AMP deaminase</fullName>
            <ecNumber evidence="4">3.5.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_1890</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Purine metabolism; IMP biosynthesis via salvage pathway; IMP from AMP: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.6" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625783.1">
        <property type="nucleotide sequence ID" value="XM_625783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR69"/>
    <dbReference type="FunCoup" id="Q5CR69">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR69"/>
    <dbReference type="GeneID" id="3372898"/>
    <dbReference type="KEGG" id="cpv:cgd4_1890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1890"/>
    <dbReference type="InParanoid" id="Q5CR69"/>
    <dbReference type="OMA" id="TEKANWI"/>
    <dbReference type="OrthoDB" id="1723809at2759"/>
    <dbReference type="UniPathway" id="UPA00591">
        <property type="reaction ID" value="UER00663"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003876">
        <property type="term" value="F:AMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046033">
        <property type="term" value="P:AMP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032264">
        <property type="term" value="P:IMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.800.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006650">
        <property type="entry name" value="A/AMP_deam_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006329">
        <property type="entry name" value="AMPD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11359:SF0">
        <property type="entry name" value="AMP DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19326">
        <property type="entry name" value="AMP_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00485">
        <property type="entry name" value="A_DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="846" mass="98446" checksum="5F8F19E7BB16FE43" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRG1</accession>
    <name>Q5CRG1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_2890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626225.1">
        <property type="nucleotide sequence ID" value="XM_626225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRG1"/>
    <dbReference type="STRING" id="353152.Q5CRG1"/>
    <dbReference type="GeneID" id="3373239"/>
    <dbReference type="KEGG" id="cpv:cgd5_2890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2890"/>
    <dbReference type="InParanoid" id="Q5CRG1"/>
    <dbReference type="OrthoDB" id="337620at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="346" mass="40247" checksum="CCE750A9AB4B115C" modified="2005-04-12" version="1">MKINNCVNILLGNVGLCSNLNAHHFRKMALKCDIICIYHNFEESDLNSILAIGRNPTNRVSYKDFYKTSSILFAPFFNKIKRLFKKNVNNMFMWYSYFRGNIYLENTSRIIFEVPDGYKLQKQSIDFWEFDVGGCFLNFRRLILANVNFTYFCSIKKQISCIKSLRYSIKEIVWKNFISELIFNPQIKLNKIEDETVIINLNEITSFIICGKFSNSNLSKDFLTLFGHGELIPIGSNSFQSNNCNFDNYILKSIVFSREDILYFISVFPVNKVIGPDFNNYLIPNQFISMFELHHSNSNLLSNINKIHSGKSSSPKFTKFIFYDSVNITKTSVDPENNTHLQVISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRK8</accession>
    <name>Q5CRK8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved possible esterase of the beta-lactamase family, of possible plant or bacterial origin, possible transmembrane domain within N terminal region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_2410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626178.1">
        <property type="nucleotide sequence ID" value="XM_626178.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRK8"/>
    <dbReference type="STRING" id="353152.Q5CRK8"/>
    <dbReference type="GeneID" id="3373350"/>
    <dbReference type="KEGG" id="cpv:cgd5_2410"/>
    <dbReference type="InParanoid" id="Q5CRK8"/>
    <dbReference type="OMA" id="DPICHYW"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.710.10">
        <property type="entry name" value="DD-peptidase/beta-lactamase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001466">
        <property type="entry name" value="Beta-lactam-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012338">
        <property type="entry name" value="Beta-lactam/transpept-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052907">
        <property type="entry name" value="Beta-lactamase/esterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319">
        <property type="entry name" value="BETA-LACTAMASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43319:SF3">
        <property type="entry name" value="BETA-LACTAMASE-RELATED DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00144">
        <property type="entry name" value="Beta-lactamase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56601">
        <property type="entry name" value="beta-lactamase/transpeptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="144"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-lactamase-related" evidence="3">
        <location>
            <begin position="97"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="374"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="374"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="629" mass="73155" checksum="335640EAC16AA37F" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRK9</accession>
    <name>Q5CRK9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein of possible plant or bacterial origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626177.1">
        <property type="nucleotide sequence ID" value="XM_626177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRK9"/>
    <dbReference type="STRING" id="353152.Q5CRK9"/>
    <dbReference type="GeneID" id="3373147"/>
    <dbReference type="KEGG" id="cpv:cgd5_2400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2400"/>
    <dbReference type="InParanoid" id="Q5CRK9"/>
    <dbReference type="OMA" id="ESDISTM"/>
    <dbReference type="OrthoDB" id="427480at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05121">
        <property type="entry name" value="ABC1_ADCK3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051130">
        <property type="entry name" value="Mito_struct-func_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43173:SF3">
        <property type="entry name" value="ABC1 FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="120"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="322" mass="38458" checksum="4B0F1E52A97F7317" modified="2005-04-12" version="1">MNELDSWNRKWRTLWCWTHIYVHYKRAQIYTRNLPEEVKYIYWNSKHSQFAELIWRNISELRGWWIKVGQFLSTRGDLLPREYVTYLGKLQDIMPCMEWNIVEGILKEELGKDIEKVFKEIQEKPIAAASISQVHKAVLSEGEKKVVIKIQYPNIQETLNHDMKNLEQLTWAFGLLEDYSDSIHILNEWKSSAYSELDFKNELKNQKRAYEMFEDSGIEIIIPKVYTEYTTEKILTMEYIKGFNILNKMLLKENRVNKRELLEILCDSFAYQIHIHGFFHGDPQPSNILVVYDELKRKYIPAILDWGMVKIFDKSKQIAFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRR9</accession>
    <name>Q5CRR9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">NOL1/NOP2/Sun domain family member 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd5_1730</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in rRNA + S-adenosyl-L-methionine = a 5-methylcytidine in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:61484"/>
            <dbReference type="Rhea" id="RHEA-COMP:15836"/>
            <dbReference type="Rhea" id="RHEA-COMP:15837"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74483"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626117.1">
        <property type="nucleotide sequence ID" value="XM_626117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRR9"/>
    <dbReference type="FunCoup" id="Q5CRR9">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRR9"/>
    <dbReference type="GeneID" id="3373010"/>
    <dbReference type="KEGG" id="cpv:cgd5_1730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1730"/>
    <dbReference type="InParanoid" id="Q5CRR9"/>
    <dbReference type="OMA" id="NICCINL"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005762">
        <property type="term" value="C:mitochondrial large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031167">
        <property type="term" value="P:rRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF3">
        <property type="entry name" value="5-METHYLCYTOSINE RRNA METHYLTRANSFERASE NSUN4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="12">
        <location>
            <begin position="29"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="119"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="208"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00049302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="374" mass="43274" checksum="846011B8F18205FF" modified="2005-04-12" version="1">MLISNLCGKFGWIAYHEYLFTKERLHKSLLPALSANPRHVAVVNQFDSSKAHLIEINGKIYKRWVFPFTYYLTYDNKFNLLENEPLIVPEKCIYFMDAASIIVSYLLDIDRFSTVLDLCSAPGGKALIIIKRILEDINKHGEKDKMCHITCNEYDKGRFSRLNKVLQSHIGSFDLNRVNAVTISNDATSPSLLYSLRKQSRFLKILVDAPCSSDRHLILSNDFKHWSIKLAKRNSERQAEIINNAIGLLQDNGIILYCTCTLNEIENDYTVERICNNLEISTNDCFKLMLNIIKEFNNRYDQVKIILKPIRNELKKEEFDEKSNEKLCFNIEGNEKNIIVFEYTKFGSYILPDSNNGIGPLYLAFIKKKKINTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS73</accession>
    <name>Q5CS73_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_3830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628194.1">
        <property type="nucleotide sequence ID" value="XM_628194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS73"/>
    <dbReference type="GeneID" id="3371505"/>
    <dbReference type="KEGG" id="cpv:cgd1_3830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3830"/>
    <dbReference type="InParanoid" id="Q5CS73"/>
    <dbReference type="OrthoDB" id="344202at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254321" evidence="2">
        <location>
            <begin position="23"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="30"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="103" mass="11905" checksum="60F172DA1434689C" modified="2005-04-12" version="1">MKVFYLTKILFLILILGVFVKSENFRSAQELEENTSNSEEENQNSPKNFVSNTISEYYNHVSSAATNKFNEETQKLKSRFKDMIQSAGESIKNFITEKVNLIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSB0</accession>
    <name>Q5CSB0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628157.1">
        <property type="nucleotide sequence ID" value="XM_628157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSB0"/>
    <dbReference type="GeneID" id="3371583"/>
    <dbReference type="KEGG" id="cpv:cgd1_3430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3430"/>
    <dbReference type="InParanoid" id="Q5CSB0"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="103" mass="12205" checksum="C5225EB849552541" modified="2005-04-12" version="1">MINILVNILNNIAKYLISIYSFLDFLKIVIQFFATFLFKCYPSLLFFNDIPLLLCVPYVSILYIQEQIANCLSRQHVYLEILCNFIKKKKKYLVVIFIVRKNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSB3</accession>
    <name>Q5CSB3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_3400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628154.1">
        <property type="nucleotide sequence ID" value="XM_628154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSB3"/>
    <dbReference type="GeneID" id="3371585"/>
    <dbReference type="KEGG" id="cpv:cgd1_3400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3400"/>
    <dbReference type="InParanoid" id="Q5CSB3"/>
    <dbReference type="OrthoDB" id="343358at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="383" mass="42318" checksum="29480F36DFD06EF2" modified="2005-04-12" version="1">MASIEVYREAIRTVIEYVSTKYGPEEETVINMILESKGIPGIFRGQSIHLVENMMIGRGHGIMLENSMDHDSRIPPIDTNNNNNNTGLNIISSMIQPAMQQQIQPIIHHPIIQHPISPEIQTLIQSPMIAQSLIQQQQQQQQIHSLTAGTVASSSITINSNTNTNSASVSSPNYLEQPSTTVVTKTHNFQYENSGDEKSISSVVAVANTGCNSPSLTSSSYSFSSSSAEPLILSNSNTTTTTTTTTTTTTTSSFTKNNDNSINSIKITNNNEKDINNSNIINTHNNMTESTTYNSELSKQLKENSNFNIETQVSDEKTNEQIDNINKFDEKENDIEDISEKIRTMLRMATNVNELNQAIKMAYSVGLTYEAGLGERKLKKLLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSD0</accession>
    <name>Q5CSD0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628137.1">
        <property type="nucleotide sequence ID" value="XM_628137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSD0"/>
    <dbReference type="GeneID" id="3371461"/>
    <dbReference type="KEGG" id="cpv:cgd1_3210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3210"/>
    <dbReference type="InParanoid" id="Q5CSD0"/>
    <dbReference type="OMA" id="THYYAND"/>
    <dbReference type="OrthoDB" id="340462at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1040" mass="119357" checksum="2E8561CC1E4D22EC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSJ8</accession>
    <name>Q5CSJ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal peptide, secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628069.1">
        <property type="nucleotide sequence ID" value="XM_628069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSJ8"/>
    <dbReference type="GeneID" id="3371705"/>
    <dbReference type="KEGG" id="cpv:cgd1_2400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2400"/>
    <dbReference type="InParanoid" id="Q5CSJ8"/>
    <dbReference type="OrthoDB" id="343187at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254478" evidence="1">
        <location>
            <begin position="22"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="331" mass="37609" checksum="537F8755E15673BD" modified="2005-04-12" version="1">MKYYLPFGVLLLIIQLYLSRCSESSEDTESEVLSIQDSSELRDCKQAISGISGAGYHEFTLDPSLLKVISEMGNSGQPCRFIVVDGMQQNYQQADDGGSSSQVNYLSQQVQTPMQMTMQTQMPVQMPMQMPMQMPTQMQIQRTNQGLQFGHGNMVQWVGGPVNFDNMVDCKFYRQNPGFCVPMSIYTPCSRCKARVRTIFRTSYKVRCPGQESFPAQLRPYFAWVPTSHRNPKRERGIFSRWRRQFMCIVMAISDIPKDVSLFWQHSQITFDSAYETPQYVPLLLGPYGDQSTALGYAAGTNFLTSSGLSYQGARHYIQNQNSERNAHEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSN6</accession>
    <name>Q5CSN6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat protein, predicted histone deacetylase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_1930</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628031.1">
        <property type="nucleotide sequence ID" value="XM_628031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSN6"/>
    <dbReference type="FunCoup" id="Q5CSN6">
        <property type="interactions" value="420"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSN6"/>
    <dbReference type="GeneID" id="3371525"/>
    <dbReference type="KEGG" id="cpv:cgd1_1930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1930"/>
    <dbReference type="InParanoid" id="Q5CSN6"/>
    <dbReference type="OMA" id="HVFDSHE"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="35"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="207"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="258"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="375"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="491" mass="55439" checksum="B9F26A5AA40F450E" modified="2005-04-12" version="1">MNSLVQNSPFSSMMNFTFFDQAKKILQSEESNKLEKYKIWKENTSLLYENIMTHILEWPSLSVQWMCESSISDVESFYSDEGINETSKYSLLTGTHTSGMDQDYIIILDVLLPNCPIPENCRKFDSHSDYAGFTIPHMEADSNNFSQRILIPHDGEVNRVVSSPMNRNIIASKTVVGNVNIYDLNSLVDEKMVKGTVKTENNPSLILCGHELEGWALSWNKIKESYLASGSDDNVICLWDIQSKPNNYERKLKPILKFMGHEKSVQDISWNPSNENIMISVGDDGLIMIWDIRESASPCCTIKTLKEHCSDNTKINFNFKKSVGYSCIGHCSTNINSLNTIEFNPFQTNIIAVGGSDPVIAIFDIRNMSKRLHSLNGHSGQINRLSFLLENESLLASASSDSTVSIWDLSKIGMEQRPDEVEDGVPELIFTHSGHTSPVIDLSCMTNYLQTTTFASISENNYLHIWSPGEAMFLSDDEDEELERIKDIQVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSQ9</accession>
    <name>Q5CSQ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Insulinase like protease, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd1_1680</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628008.1">
        <property type="nucleotide sequence ID" value="XM_628008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSQ9"/>
    <dbReference type="STRING" id="353152.Q5CSQ9"/>
    <dbReference type="GeneID" id="3371360"/>
    <dbReference type="KEGG" id="cpv:cgd1_1680"/>
    <dbReference type="InParanoid" id="Q5CSQ9"/>
    <dbReference type="OMA" id="EERTIYF"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000012">
        <property type="entry name" value="Protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254483" evidence="8">
        <location>
            <begin position="22"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="60"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="223"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="11">
        <location>
            <begin position="422"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="12">
        <location>
            <begin position="843"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1033" mass="120139" checksum="DDABBDBF4EF5F8C6" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSX9</accession>
    <name>Q5CSX9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627938.1">
        <property type="nucleotide sequence ID" value="XM_627938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSX9"/>
    <dbReference type="STRING" id="353152.Q5CSX9"/>
    <dbReference type="GeneID" id="3371369"/>
    <dbReference type="KEGG" id="cpv:cgd1_920"/>
    <dbReference type="InParanoid" id="Q5CSX9"/>
    <dbReference type="OMA" id="IDHGHIS"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000050">
        <property type="entry name" value="Actin, alpha skeletal muscle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="405" mass="45916" checksum="B408F1511BAEE907" modified="2005-04-12" version="1" fragment="single">LYLKKKMSSFSGDQAANGEQCIVIDCGSAYMKAGTDSDKSPTCIFPSMVGQYRSRYVPEDEDNNPIFVGEEAIAQRKKLSLTFPIDHGHIDDWTKFEELLNYLFYRGLDIDPIDSSVIITKPPLCSNRHEEKITELMFEMFQTQSLNIALQGLMALYSAGRTTGVACDIGEGVTQVVPVYDGYCDSSSLRRADIGGQEITMYLQKLLSDKGYIATTRDDLEHVRIIKETLCYIAKDPAAENERPEEEINEVYTLPDGLTLHDEHTNKIEIDKERFYAPEVIFDPKLIMRDVQPVHELIMESIMSSPMEVRKTLMGSILLSGGTSLTTGIEERLEEELMYICPSQAKSNIRVTPADDRNYAIWKGAQLFSALRDYQENLWISRDEYLEEGVNICIKKQPFFSSIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT16</accession>
    <name>Q5CT16_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627901.1">
        <property type="nucleotide sequence ID" value="XM_627901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT16"/>
    <dbReference type="FunCoup" id="Q5CT16">
        <property type="interactions" value="292"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT16"/>
    <dbReference type="GeneID" id="3371376"/>
    <dbReference type="KEGG" id="cpv:cgd1_410"/>
    <dbReference type="InParanoid" id="Q5CT16"/>
    <dbReference type="OMA" id="APDGMFT"/>
    <dbReference type="OrthoDB" id="19692at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23795">
        <property type="entry name" value="UBCc_UBE2G1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000051">
        <property type="entry name" value="ubiquitin-conjugating enzyme E2 R2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="156" mass="17888" checksum="143FF66BA0E78D74" modified="2005-04-12" version="1" fragment="single">FFVYSELIRDDTSGFSVGLDDDSNFLRWRVCFEGPPDTLYEGGIFNALLTFPEDFPNSPPKMCFEQEMWHPNVYPDGNVCISILHPPGHDRYNEQESPDERWRPIFGVESILVSVISMLGEPNLDSPANIDAALEFKNNINEYKKKVRAIVRQSVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT50</accession>
    <name>Q5CT50_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">UDP-galactose transporter, predicted signal peptide and 9 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd1_40</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627867.1">
        <property type="nucleotide sequence ID" value="XM_627867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT50"/>
    <dbReference type="FunCoup" id="Q5CT50">
        <property type="interactions" value="385"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT50"/>
    <dbReference type="GeneID" id="3371439"/>
    <dbReference type="KEGG" id="cpv:cgd1_40"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_40"/>
    <dbReference type="InParanoid" id="Q5CT50"/>
    <dbReference type="OMA" id="CGAIGQV"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005459">
        <property type="term" value="F:UDP-galactose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005460">
        <property type="term" value="F:UDP-glucose transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013657">
        <property type="entry name" value="SCL35B1-4/HUT1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10778:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35 MEMBER B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08449">
        <property type="entry name" value="UAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="337" mass="37812" checksum="63022DA829C9A083" modified="2005-04-12" version="1">MNDTIIGAFCVAGIYFFFIFYGIVQERIHTLGDKKVGDNFNYSLFLVFCFCLVNTVVSFGVIQLENWRIGPGKEGNSKKNKNSSNAEKTLFNLSFECIFQIMLTSATYLTSMVLTNLALGNVNYPTQVLVKSAKCVPIIVIGTLYFKTKYPWYDYLAVIVITISLSCFNLMQIKTNKVGTVQTLSGVSLLGLSLLCDGLTGPRQDKLIKKYNVTSNILMFYTNLFAMILCGILSLFLEGKEPYLFISRFPSTPYYILALSLTGTCGQFFIFQSLIRFGSLYLAIITTTRKFFTVLVSVIIFGHKLSLGQWLCVSAIFVALGIQTVFSRKNKDKLKTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTB7</accession>
    <name>Q5CTB7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626552.1">
        <property type="nucleotide sequence ID" value="XM_626552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTB7"/>
    <dbReference type="GeneID" id="3373619"/>
    <dbReference type="KEGG" id="cpv:cgd2_3650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3650"/>
    <dbReference type="InParanoid" id="Q5CTB7"/>
    <dbReference type="OMA" id="AERDACH"/>
    <dbReference type="OrthoDB" id="166018at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899">
        <property type="entry name" value="DOMAIN OOKINETE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899:SF1">
        <property type="entry name" value="PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="323" mass="37042" checksum="1107E244C7D36AF6" modified="2005-04-12" version="1">MKDNVRERLILRLGITKNDGERRVHASGHDRSMIHSSKKSCGDSTDEVKEHDDFLFRLLDLSQNDSSRLKYLEKLSYLKIWVPSAHRPPKHQTAIIFDWDDTLLCTTFLNYQITKRNRISGSSNSQQVVNDSAQGKLEKDIIACQGGCSDNFLSTFLPEDVQMIMNQIQKCVVELLIKAMDMGNVFLITNASEGWVDYSAKMYMPEVVDVLSRLTVISARSKYEHKYPGAYHKWKFNAFLEIQKKLDSETITNLISIGDSIIEMEAVHILGREFSESLVKTIKMKESPTPDELFKQLSLINTKFEDICLNARNLKIVLEKRSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTE7</accession>
    <name>Q5CTE7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Secreted papain like protease, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_3320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>chloride</name>
            <dbReference type="ChEBI" id="CHEBI:17996"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626522.1">
        <property type="nucleotide sequence ID" value="XM_626522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTE7"/>
    <dbReference type="STRING" id="353152.Q5CTE7"/>
    <dbReference type="GeneID" id="3373699"/>
    <dbReference type="KEGG" id="cpv:cgd2_3320"/>
    <dbReference type="InParanoid" id="Q5CTE7"/>
    <dbReference type="OMA" id="DFFNQGC"/>
    <dbReference type="OrthoDB" id="3789175at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.80">
        <property type="entry name" value="Cathepsin C, exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014882">
        <property type="entry name" value="CathepsinC_exc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036496">
        <property type="entry name" value="CathepsinC_exc_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08773">
        <property type="entry name" value="CathepsinC_exc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75001">
        <property type="entry name" value="Dipeptidyl peptidase I (cathepsin C), exclusion domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0865">Zymogen</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254380" evidence="6">
        <location>
            <begin position="36"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="7">
        <location>
            <begin position="373"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="520"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="529"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="600"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="819" mass="95096" checksum="ABE49928416B2D86" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTF2</accession>
    <name>Q5CTF2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_3270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626517.1">
        <property type="nucleotide sequence ID" value="XM_626517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTF2"/>
    <dbReference type="SMR" id="Q5CTF2"/>
    <dbReference type="STRING" id="353152.Q5CTF2"/>
    <dbReference type="GeneID" id="3373553"/>
    <dbReference type="KEGG" id="cpv:cgd2_3270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3270"/>
    <dbReference type="InParanoid" id="Q5CTF2"/>
    <dbReference type="OMA" id="WIQDRAN"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254382" description="phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)" evidence="9">
        <location>
            <begin position="21"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="10">
        <location>
            <begin position="114"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="291"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="412"/>
            <end position="520"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="670" mass="74827" checksum="BF56D32B81E8C4AB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTJ0</accession>
    <name>Q5CTJ0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_2790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626479.1">
        <property type="nucleotide sequence ID" value="XM_626479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTJ0"/>
    <dbReference type="FunCoup" id="Q5CTJ0">
        <property type="interactions" value="628"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTJ0"/>
    <dbReference type="GeneID" id="3373473"/>
    <dbReference type="KEGG" id="cpv:cgd2_2790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2790"/>
    <dbReference type="InParanoid" id="Q5CTJ0"/>
    <dbReference type="OMA" id="GREMFYF"/>
    <dbReference type="OrthoDB" id="278280at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.400.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032378">
        <property type="entry name" value="ZC3H15/TMA46_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681:SF0">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12681">
        <property type="entry name" value="ZINC FINGER-CONTAINING PROTEIN P48ZNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16543">
        <property type="entry name" value="DFRP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="142"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="311"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="340" mass="38814" checksum="E568C551ACE4C7C8" modified="2005-04-12" version="1">MPPKNQSKQERGQQRALEKQKQKIIEDKTFGLKNKNKSKSVQKYIKSVTSQINNSKGGQVNQELKAAQAKEEKKKQAQQQALLAALFKGTENIKKVSAEDARKVDPSTIKAEQKIDLYIDQRDQKQNSGSKKAPLSQEPTSFSTEIICKHFLSAVEKKQYGWFWVCPEGGDNCKYRHCLPVGYVIKEQESDDGGDIEGEEETLEERIERQRLELPGPGTPVTFETFMEWKKKKEKEEEEKAKADAAKQGKQMSGRDLFVYDPSLFVDDEDAAGGDTYEIDEDAFLSDDDIPEMNAYSEIIEEEENQVESIENDHKDRDKNSPEVKINHSIFQNEIDLPEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTK8</accession>
    <name>Q5CTK8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626461.1">
        <property type="nucleotide sequence ID" value="XM_626461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTK8"/>
    <dbReference type="GeneID" id="3373640"/>
    <dbReference type="KEGG" id="cpv:cgd2_2590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2590"/>
    <dbReference type="InParanoid" id="Q5CTK8"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="127" mass="14243" checksum="B90CF372A732DE42" modified="2005-04-12" version="1">MTSILFATQFSLTNPGNSLRTFFSTVPSDKILFLRSKSSIKYSFIYATTNLAKFTSPKEWELYGRSRSSFPETIPKGISNGSFPTSVITLLMEIRLSICTNGSSLLLANFKRINLKNAAESFLKTFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTM2</accession>
    <name>Q5CTM2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_2450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626447.1">
        <property type="nucleotide sequence ID" value="XM_626447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTM2"/>
    <dbReference type="GeneID" id="3373499"/>
    <dbReference type="KEGG" id="cpv:cgd2_2450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2450"/>
    <dbReference type="InParanoid" id="Q5CTM2"/>
    <dbReference type="OrthoDB" id="342233at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253835" evidence="1">
        <location>
            <begin position="24"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="167" mass="18674" checksum="28A5D26A89657118" modified="2005-04-12" version="1">MMGRLTIEIFLSIIILFISCSTQLELDIMKDIGTNNKDFFQKEISPVAISRIIAIKDQLRIFSGSNADTSIREGNFISTIMANNLKEYIGLDHKVMSGSNRGAFVIYDTNDYPFACNCNSAQYQNWKNASENQNIKVECTNTINTGIFNSNDIDYCDPTNIAASQSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTS0</accession>
    <name>Q5CTS0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_1840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626399.1">
        <property type="nucleotide sequence ID" value="XM_626399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTS0"/>
    <dbReference type="GeneID" id="3373738"/>
    <dbReference type="KEGG" id="cpv:cgd2_1840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1840"/>
    <dbReference type="InParanoid" id="Q5CTS0"/>
    <dbReference type="OMA" id="GHICEIK"/>
    <dbReference type="OrthoDB" id="340908at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254513" evidence="2">
        <location>
            <begin position="20"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="294"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="515" mass="57712" checksum="51D2F69A6B2F0F35" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTU1</accession>
    <name>Q5CTU1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dolichol kinase</fullName>
            <ecNumber evidence="3">2.7.1.108</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd2_1560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the polyprenol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.108" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626378.1">
        <property type="nucleotide sequence ID" value="XM_626378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTU1"/>
    <dbReference type="STRING" id="353152.Q5CTU1"/>
    <dbReference type="GeneID" id="3373717"/>
    <dbReference type="KEGG" id="cpv:cgd2_1560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1560"/>
    <dbReference type="InParanoid" id="Q5CTU1"/>
    <dbReference type="OMA" id="SIDNFML"/>
    <dbReference type="OrthoDB" id="343846at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004168">
        <property type="term" value="F:dolichol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043048">
        <property type="term" value="P:dolichyl monophosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032974">
        <property type="entry name" value="Polypren_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205:SF15">
        <property type="entry name" value="DOLICHOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13205">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 15-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="118"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="246"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="286"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="324"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="398"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="467"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="532" mass="61224" checksum="BFFCBD924FC4E6DE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTV7</accession>
    <name>Q5CTV7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_1390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626362.1">
        <property type="nucleotide sequence ID" value="XM_626362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTV7"/>
    <dbReference type="GeneID" id="3373572"/>
    <dbReference type="KEGG" id="cpv:cgd2_1390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1390"/>
    <dbReference type="InParanoid" id="Q5CTV7"/>
    <dbReference type="OMA" id="IKFCVEY"/>
    <dbReference type="OrthoDB" id="361835at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33828:SF2">
        <property type="entry name" value="NUCLEOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33828">
        <property type="entry name" value="OS05G0596200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="196" mass="22015" checksum="350A10A5A4994E58" modified="2005-04-12" version="1">MSDSDSDTVLSKRISKRSSKSCANIKNEELDSDFSDNIPLNSRIKKKAQRPKKTAANTKNTKKASKKPTKKAKSASKPPSKPRKRQSIKSENDSEDDDINKDIKKQFRDGQKYITPPNGDATRAFYESLYNENPYSIIALKYCVENGILMGAKHTSAYKRLEHLRESGLLKRSLGGIQNEAIESLKRFDSKNGGFP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTW3</accession>
    <name>Q5CTW3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">11 transmembrane domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_1310</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626356.1">
        <property type="nucleotide sequence ID" value="XM_626356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTW3"/>
    <dbReference type="GeneID" id="3373576"/>
    <dbReference type="KEGG" id="cpv:cgd2_1310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1310"/>
    <dbReference type="InParanoid" id="Q5CTW3"/>
    <dbReference type="OMA" id="IQMLRLN"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="176"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="405"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="436"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="482" mass="54336" checksum="FE4207B4FE262130" modified="2005-04-12" version="1">MDNESQNRNENSPLLRKDDQKTPYGINRYILLIIYCVFCGLTTSAIQQSICIRFIMNKLGAYEWVCDGIPTEILPTGAKCKAQDNYITTCWTAGIMAPNIILSVLGGGKLFDNLGPKLTGFIGQVMFMLGLLIFCISNQNFPLYPLGFILIGLPQGPIFNSVVSVSNLFPNHGNKIISILSTMGDVSAFVFYFIYHFHEFSGIRIRNILIFYSIFVCGTLAMVALLLIPKNSFEKFQGSDSIEEEDSNSELTFNTTCSTEMISLHNQSLINQLKSSFFILLLPYFTLTVFRSDSIKACLDSFLQSANNTDIDLIRSQMSIFSTLQCFSFIFSLMNGFIMDKIGVSKGMIFQNSLGIIVSFLFLFNASHIVRIFSFFIFFSYASCIYSTAYCYLVECFGFSNINFLMALTTAPVGFIYIVIPIMYSKLNPSNFFYFHLFYVVSSFIMYVTPINLLMNNPNETQEANLSDGLSSVQVDEPKKFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTX2</accession>
    <name>Q5CTX2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626347.1">
        <property type="nucleotide sequence ID" value="XM_626347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTX2"/>
    <dbReference type="GeneID" id="3373578"/>
    <dbReference type="KEGG" id="cpv:cgd2_1220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1220"/>
    <dbReference type="InParanoid" id="Q5CTX2"/>
    <dbReference type="OMA" id="CWEAREC"/>
    <dbReference type="OrthoDB" id="336882at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="571" mass="65990" checksum="F15E6EC36841E498" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTY7</accession>
    <name>Q5CTY7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome regulatory subunit Rpn9, PINT domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_1020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88854.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626332.1">
        <property type="nucleotide sequence ID" value="XM_626332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTY7"/>
    <dbReference type="FunCoup" id="Q5CTY7">
        <property type="interactions" value="589"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTY7"/>
    <dbReference type="GeneID" id="3373597"/>
    <dbReference type="KEGG" id="cpv:cgd2_1020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1020"/>
    <dbReference type="InParanoid" id="Q5CTY7"/>
    <dbReference type="OMA" id="SFEDYWE"/>
    <dbReference type="OrthoDB" id="1093at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054179">
        <property type="entry name" value="PSD13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035298">
        <property type="entry name" value="PSMD13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10539:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22037">
        <property type="entry name" value="PSD13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="200"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88854.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="430" mass="49683" checksum="0857D911C29BDF23" modified="2005-04-12" version="1">MMESRTPLEQLEIELNKRVEHKEQIEQLKSYLKEKLYFQFLESSLEYISTDGLKVCGNELCEFLVNAVEPLKSNFDPLRYAVFVGEVLSRSPISIQEKVELLKKTMGDEDLYQVKENYKNASLTQEQNIAPKQEIKGDLYFRCLLALEYSKSKDLSVDCEEMLEFLTKKLEFYRGLEAEILALYHRSYASYEKTMGRVSRFYRQTIHYLSYTPLNKIPYKEKPSLVYELIMAAVISEEIYNMGELVLHPIVQEFSSIVKGNNSNQMIDELTKKEFAENAWILEILVSLHEGDLNSFMNAITKYQDKVSKTPLSTPDARVCITKKTATLALMDLAFRKNKNERVLTFDEIAKHCRIGANEIELLVMKAINMNLIKGIIDQASQTVEISWVHSRVLDKTRMKLLMDKIDNWIGSTTDIVSQLENIAPELVNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU19</accession>
    <name>Q5CU19_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Possible conserved acid phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626300.1">
        <property type="nucleotide sequence ID" value="XM_626300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU19"/>
    <dbReference type="SMR" id="Q5CU19"/>
    <dbReference type="STRING" id="353152.Q5CU19"/>
    <dbReference type="GeneID" id="3373384"/>
    <dbReference type="KEGG" id="cpv:cgd2_640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_640"/>
    <dbReference type="InParanoid" id="Q5CU19"/>
    <dbReference type="OMA" id="CLFEMSA"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254964" evidence="4">
        <location>
            <begin position="19"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="314"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="339" mass="37637" checksum="732195424ED3601A" modified="2005-04-12" version="1">MRALLLVFGIVLCIFVSSNRVNGELYFASLSNYGCSGNQKKVASVLKAQAEKTPFSLLVSPGDNFPGGIDFKHCFENIYSEKSLQIPLFAAMGQADWDNGNANLLLKRNNVTYDSNNDIFPRFSFPNYFYHYVSHYTDTSNVLSRRDGTVLFVFIDTFILSSSFPDHKVSEQAFQNLNATLHYGHKHHDFTVVVGNKYLASSYSIDSSLKKVQQLILDTHVELVISGQNRGTYNSTIEGTTFLNCDSYCSFKVDGSKMVPYIIQNGNQVELSPINTQLPSPSLSFQGIAGDELPALEMIELTFKKGAKHLSREAFLKIVGTVGLMILATCIGSLIINKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU45</accession>
    <name>Q5CU45_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Peptidase'insulinase like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd3_4260</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626969.1">
        <property type="nucleotide sequence ID" value="XM_626969.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU45"/>
    <dbReference type="SMR" id="Q5CU45"/>
    <dbReference type="STRING" id="353152.Q5CU45"/>
    <dbReference type="GeneID" id="3374059"/>
    <dbReference type="KEGG" id="cpv:cgd3_4260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4260"/>
    <dbReference type="InParanoid" id="Q5CU45"/>
    <dbReference type="OMA" id="WIFDEMK"/>
    <dbReference type="OrthoDB" id="342036at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000012">
        <property type="entry name" value="Protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="6"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="10">
        <location>
            <begin position="84"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="11">
        <location>
            <begin position="244"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="12">
        <location>
            <begin position="435"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="13">
        <location>
            <begin position="977"/>
            <end position="1066"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK88945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1172" mass="136916" checksum="59E577E5422FCBBD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU64</accession>
    <name>Q5CU64_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Histone transcription regulator (HIR1)-like WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_4060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626950.1">
        <property type="nucleotide sequence ID" value="XM_626950.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU64"/>
    <dbReference type="GeneID" id="3373894"/>
    <dbReference type="KEGG" id="cpv:cgd3_4060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4060"/>
    <dbReference type="InParanoid" id="Q5CU64"/>
    <dbReference type="OMA" id="SIMANFI"/>
    <dbReference type="OrthoDB" id="340078at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000417">
        <property type="term" value="C:HIR complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031120">
        <property type="entry name" value="HIR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831">
        <property type="entry name" value="MEMBER OF THE HIR1 FAMILY OF WD-REPEAT PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13831:SF0">
        <property type="entry name" value="PROTEIN HIRA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101908">
        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="536"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1256"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="574"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1317" mass="151967" checksum="B64529D46D8D0A61" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU75</accession>
    <name>Q5CU75_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_3940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626939.1">
        <property type="nucleotide sequence ID" value="XM_626939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU75"/>
    <dbReference type="GeneID" id="3373847"/>
    <dbReference type="KEGG" id="cpv:cgd3_3940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3940"/>
    <dbReference type="InParanoid" id="Q5CU75"/>
    <dbReference type="OMA" id="ANVMHID"/>
    <dbReference type="OrthoDB" id="336673at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="439" mass="50332" checksum="1C0CBE4FDFBC6A4C" modified="2005-04-12" version="1">MQGVNVNVYNRQKSYGTTSAGHAYGMTSGLSMQTVQDMAGVSGSYMNTDTFSTKDYADPIIFDNKKSFFNSIKFKRFKKRYAGVLGFAILICFLIGFYLILFSAKHPTSKISKNKSVFEDEHIQFTHDDFLGHSGARHGLNSNEKDSHSNDWSDFEDDWIDEHDFLEEEIDDVEDSEHGHSHYAKMINEMDSHHHDNGSPIETSFDASPKPLKSTDDLDTHKNNEQVIQTTDKLPNEVHGTVPPKPLTEIPSHEESIVYFPKTIHLLGRIGDDSAVNGKYNVMMHPYHEESPWIHGGRLIWYKTGKNSSNNYYIFYEKKLHNWVLTDKFDLDNPNPIAFLPDHGVMPVKGVGKHGCKAQHYWYFREKTSDNSHKLVMDRSVLVTDNGILLDSLPDHEHRKGPSTNQEVIGLKLHKNQIHIDHKYYSDKYSGRHQIDNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUB2</accession>
    <name>Q5CUB2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_3510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626902.1">
        <property type="nucleotide sequence ID" value="XM_626902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUB2"/>
    <dbReference type="GeneID" id="3374112"/>
    <dbReference type="KEGG" id="cpv:cgd3_3510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3510"/>
    <dbReference type="InParanoid" id="Q5CUB2"/>
    <dbReference type="OrthoDB" id="337016at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="121" mass="13818" checksum="D3AFA937EA5CFBE1" modified="2005-04-12" version="1">MAELILNRISEALGFGTKCCSKCIFEGEKETLQCYDLDPPQIVNEISKINNKNTVIGLDCNQKEHEEDLARDAARKVFGTDLENSPTVKREERIIQEESSVPKLDLLKEENQRTIKFEDCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUD9</accession>
    <name>Q5CUD9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_3240</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626875.1">
        <property type="nucleotide sequence ID" value="XM_626875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUD9"/>
    <dbReference type="GeneID" id="3373875"/>
    <dbReference type="KEGG" id="cpv:cgd3_3240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3240"/>
    <dbReference type="InParanoid" id="Q5CUD9"/>
    <dbReference type="OMA" id="QISTECI"/>
    <dbReference type="OrthoDB" id="2365600at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11375">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.10">
        <property type="entry name" value="Collagenase (Catalytic Domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024079">
        <property type="entry name" value="MetalloPept_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012962">
        <property type="entry name" value="Pept_M54_archaemetzincn"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910">
        <property type="entry name" value="ARCHAEMETZINCIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15910:SF1">
        <property type="entry name" value="ARCHAEMETZINCIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07998">
        <property type="entry name" value="Peptidase_M54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="219" mass="25069" checksum="F5A0B3C4516325E2" modified="2005-04-12" version="1">MIFLSLIGAFEPFISIDNLKFIVKNLQILTGKEIKFIKHAETNINLVMKGRCSVGNISDLKDYADLKEQSNPGNHQQISTNSMLEVLLKMKNKFITENSKNQMDSNFFLIGITSLDIFPTNDHEYVFGQSDPEKGIAIISAYRLYQNNKNLMNSRILKVIMHEYGHLMKLGHCKHVCLMSVICSISELDNRTLYCCENCLNQIREKSSTSESVKNLFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUH2</accession>
    <name>Q5CUH2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">FmRP interacting protein like, contains 2 C2H2 zinc fingers involved in RNA metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626842.1">
        <property type="nucleotide sequence ID" value="XM_626842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUH2"/>
    <dbReference type="STRING" id="353152.Q5CUH2"/>
    <dbReference type="GeneID" id="3373775"/>
    <dbReference type="KEGG" id="cpv:cgd3_2840"/>
    <dbReference type="InParanoid" id="Q5CUH2"/>
    <dbReference type="OMA" id="MISAINH"/>
    <dbReference type="OrthoDB" id="273070at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="276" mass="32834" checksum="232D491FF256D43D" modified="2005-04-12" version="1" fragment="single">IKSKQNNYSDLCQFISENILLKRANNQFQFKNNTGYATSARIYFYIKKHATQNDKLIFYMKKNNKSTYQKTRKLDNYCNVCEKGFINNEKHVQHILNFHVTCSEENCNYSAPKEIMHYHKLKHINNNEGNSITESTEEIEKWLICRKMKFPRPVCSKNHSIKSQDSNEILQDNKKKCQSTQISALEHYIRINMSNQLPFSRSKKLNKPLNKKNINYNSNLKVHKNKMYGEAFPENKKIQKSLLFRLFKSEIHIYEKKMISAINHILERSHFKNLLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUP7</accession>
    <name>Q5CUP7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626767.1">
        <property type="nucleotide sequence ID" value="XM_626767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUP7"/>
    <dbReference type="GeneID" id="3374050"/>
    <dbReference type="KEGG" id="cpv:cgd3_1970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1970"/>
    <dbReference type="InParanoid" id="Q5CUP7"/>
    <dbReference type="OMA" id="MNADKHE"/>
    <dbReference type="OrthoDB" id="342556at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="118" mass="13661" checksum="6C648680804E3047" modified="2005-04-12" version="1">MRSITIEELSEIDDDNIRQLAEIIIKGNLNEPSESRYINEILNSTGEQLNQKAQNLSQSIKEKNKKLQEMTDELQFMNISLQQLNSPKALKKMTLKELKQHCSSLRSIMTSYLDSFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUZ3</accession>
    <name>Q5CUZ3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rad60/SUMO-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626671.1">
        <property type="nucleotide sequence ID" value="XM_626671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUZ3"/>
    <dbReference type="GeneID" id="3374183"/>
    <dbReference type="KEGG" id="cpv:cgd3_900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_900"/>
    <dbReference type="InParanoid" id="Q5CUZ3"/>
    <dbReference type="OMA" id="IFGHDIS"/>
    <dbReference type="OrthoDB" id="372569at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad60/SUMO-like" evidence="2">
        <location>
            <begin position="146"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF11976"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="214" mass="25261" checksum="7C711AC3D23642E5" modified="2005-04-12" version="1">MEERNIEENNEDDDLFGEDIAFSQESVNRRLGKVQKRNRLAKKVCINKESQQNETREKISSNDNNHIEEDSDYEEFRPAVRKKISRKEDTVLTIEKTQKKVGTKNEQVSQVITIEDEEREKSVIKLNVKVYKRKESDIIVIKTLVVALYRNDLVKKLVTYISKNLNPKPEKYLEDIKVYFDGDCVNMEMEIKEIGIEDEEQLEVKVPFECNWIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV29</accession>
    <name>Q5CV29_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative fucose translocator with 8 transmembrane domains, within locus of 3 paralogous genes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626635.1">
        <property type="nucleotide sequence ID" value="XM_626635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV29"/>
    <dbReference type="STRING" id="353152.Q5CV29"/>
    <dbReference type="GeneID" id="3373800"/>
    <dbReference type="KEGG" id="cpv:cgd3_500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_500"/>
    <dbReference type="InParanoid" id="Q5CV29"/>
    <dbReference type="OMA" id="WMVVNTL"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="161"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="258"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="34"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="365"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="372"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="394" mass="42937" checksum="D24A88D424A3D1C0" modified="2005-04-12" version="1">MSKDSERPEISFMGLPRLASASIAIAVYVVCSIGCVYANKWLLSNVGACHGFIPLVQQLIGAIFVRTMVYITGICGIGSDNQNPSSDKTSQNEKQNESLVSRLWNRYKYIWPASFCFSSTIVLNNACLSMAKLSTYSVAKSTTLIWNVLFQFILLRIKLPVSTILSCFLILAGVTIGSLDTSTLAPMAVIAGCSSSIFQALYNTCIARALPKTNNDTSEVLVRNQELSSVFLVIYILASKELVNLFMHSPCFDLSSSKFLSCWAIFFLTTAFAAGLNKFTFMVIGLTEPSTFSVIGFTKAGLQTAGGWFIYKDPASIKSVTSVVFTLSGSLIYGITRGSKKSESKKEQVEEIRRLTRCSAASVGDIDAVPSPRDEEAKKSASNDEKQKLITSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV81</accession>
    <name>Q5CV81_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_5080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627388.1">
        <property type="nucleotide sequence ID" value="XM_627388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV81"/>
    <dbReference type="GeneID" id="3374229"/>
    <dbReference type="KEGG" id="cpv:cgd8_5080"/>
    <dbReference type="InParanoid" id="Q5CV81"/>
    <dbReference type="OrthoDB" id="10252102at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253894" evidence="2">
        <location>
            <begin position="29"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="90"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="112" mass="13400" checksum="B188CCECD4C5CBC2" modified="2005-04-12" version="1">MLKFRKFMVESLSLLFIVLLVHLNGVKSQIYGSAKDVLSQINTNNYPNFSDLTNYPYYLPEKAIIGYDSPSLKENIYKVEEYHNKRDLDPSHYKEFQRQKEEFSEIEKTRRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVD6</accession>
    <name>Q5CVD6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627333.1">
        <property type="nucleotide sequence ID" value="XM_627333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVD6"/>
    <dbReference type="GeneID" id="3374538"/>
    <dbReference type="KEGG" id="cpv:cgd8_4450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4450"/>
    <dbReference type="InParanoid" id="Q5CVD6"/>
    <dbReference type="OrthoDB" id="342994at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="190"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="408"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="435"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="575"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="605"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="647" mass="75461" checksum="BD5D1A69B05EBE22" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVF1</accession>
    <name>Q5CVF1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627318.1">
        <property type="nucleotide sequence ID" value="XM_627318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVF1"/>
    <dbReference type="SMR" id="Q5CVF1"/>
    <dbReference type="GeneID" id="3374550"/>
    <dbReference type="KEGG" id="cpv:cgd8_4290"/>
    <dbReference type="InParanoid" id="Q5CVF1"/>
    <dbReference type="OrthoDB" id="340921at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254551" evidence="1">
        <location>
            <begin position="24"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="238" mass="26702" checksum="706CCFA205FD6F73" modified="2005-04-12" version="1">MKMRIFFLINLLSIAGLSQYAHARLTRSTSDFGLLEPQFLPGTITTLIQTARKIIGANVEPVSVIGEGKSQISQKDSEKLYSEAVSSAVSVYQKAMNDATNNKLKQRDVVTSMPVVDSPRDPVCSVMISGELALALDPRNIFDVDLLGVKITKDDLLFMTDLKNPESLVRSFSLNKIEVPLESVQNSRKCFRMYFDGSPVVMCAKSDEERNEMMNKLTEAVSFFYLFELIQIYTKLSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVH1</accession>
    <name>Q5CVH1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SANT domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627298.1">
        <property type="nucleotide sequence ID" value="XM_627298.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVH1"/>
    <dbReference type="GeneID" id="3374185"/>
    <dbReference type="KEGG" id="cpv:cgd8_4070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4070"/>
    <dbReference type="InParanoid" id="Q5CVH1"/>
    <dbReference type="OMA" id="LASEICC"/>
    <dbReference type="OrthoDB" id="310853at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031298">
        <property type="term" value="C:replication fork protection complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043111">
        <property type="term" value="P:replication fork arrest"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044998">
        <property type="entry name" value="Timeless"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940:SF4">
        <property type="entry name" value="PROTEIN TIMELESS HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22940">
        <property type="entry name" value="TIMEOUT/TIMELESS-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26019">
        <property type="entry name" value="HTH_TIMELESS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1516"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1525"/>
            <end position="1543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1632" mass="189791" checksum="004A2449DC7CCC90" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVJ5</accession>
    <name>Q5CVJ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627274.1">
        <property type="nucleotide sequence ID" value="XM_627274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVJ5"/>
    <dbReference type="GeneID" id="3374286"/>
    <dbReference type="KEGG" id="cpv:cgd8_3820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3820"/>
    <dbReference type="InParanoid" id="Q5CVJ5"/>
    <dbReference type="OMA" id="NDNICAN"/>
    <dbReference type="OrthoDB" id="5199543at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000775">
        <property type="term" value="C:chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031390">
        <property type="term" value="C:Ctf18 RFC-like complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034088">
        <property type="term" value="P:maintenance of mitotic sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019128">
        <property type="entry name" value="Dcc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395:SF6">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13395">
        <property type="entry name" value="SISTER CHROMATID COHESION PROTEIN DCC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09724">
        <property type="entry name" value="Dcc1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="481" mass="55995" checksum="BF5807B6398E6A4E" modified="2005-04-12" version="1">MEVDFHTLYSKAASSWSLLQLDPNCEESLRNGKQLWLKGLKNNRENCNVPTVICTENETFYLRREKSSNVTYLAIESENGELIEMQNDENSPNNESYNANKLSVVGNLNSIVVMIKIPAIMNLFEDYIASHRNLTNNSHSEMTFKKLFSISQISLMELYNFLFDYSSMMYCDIEGNWYSINNEILLFLLSSLLQKGMSMNKSFRYMTVKDVKYLLRESFSELESLGESLENSINYNVLKHALSFDLTLIQLIKHIIVPADNNLGNLVFDEFVEENIKNLLSSPRIQDHVSLRNIDSMRVDFSYKRIQGILATSILKKHQVLKARDYIEEFQNILSNYIPLELSELEFEYNDTNAISDLDGEKNIKVETDFYYGFPLIENHPDNTGIRFDIIAGQAYYNHEDDAIIYLPSSSLPIDPRNRLSILFRKKKHWHISELNAYISPVLQPSIKLEAFCLKNCYVCEQNIFNKNYRLFYNKNLPLMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVM1</accession>
    <name>Q5CVM1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_3550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627248.1">
        <property type="nucleotide sequence ID" value="XM_627248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVM1"/>
    <dbReference type="STRING" id="353152.Q5CVM1"/>
    <dbReference type="GeneID" id="3374292"/>
    <dbReference type="KEGG" id="cpv:cgd8_3550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3550"/>
    <dbReference type="InParanoid" id="Q5CVM1"/>
    <dbReference type="OrthoDB" id="10625151at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="102" mass="12230" checksum="F0651E769C8F1637" modified="2005-04-12" version="1">MIKFWFTLLKFMEKQGFVSNPDHSMKLILSGLKANSIVGFKKYIMLFLLLKVLSTLKYLQGVQLYIQFFFKKMTLNKNFPERNFLLELWQQQLDIMSLLKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVT6</accession>
    <name>Q5CVT6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">LRR repeats protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_2830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627183.1">
        <property type="nucleotide sequence ID" value="XM_627183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVT6"/>
    <dbReference type="STRING" id="353152.Q5CVT6"/>
    <dbReference type="GeneID" id="3374344"/>
    <dbReference type="KEGG" id="cpv:cgd8_2830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2830"/>
    <dbReference type="InParanoid" id="Q5CVT6"/>
    <dbReference type="OMA" id="CEEMDDD"/>
    <dbReference type="OrthoDB" id="409725at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="511" mass="59180" checksum="F905EB797120A3E3" modified="2005-04-12" version="1">MEIKLGDRVLHLEDERIGTICSTVFNENGEELFGVLWDSDINCNSLNSDIQNVSSCFMNRNKVEKKLELHKINELSSGISFQEAIRNRYLCDEEVENFVGLKKAQEYCKKISILSLERMSIVTCACKELMKSLESPVDFTQCYNNINSLCLNNNLLSDWNSLFCILSHLPKLECLMLNGNRLKEISFINHNQFNNIKVLSMSKTFVKFEQLMLLFREDSVLPNVNYVNLSSNNYYFISMDYSNSTIQRLDLSLNLLSDWENIENILKYLTGLKSLNISSNYFFKLPILKTNTNINIEFPNILELNLDNCGIIELGTIVYLRKAFPNLEHLCLRNNIILNNTTIDLRSIIISILPNIKTFNKSIINKQDIISYQRYYISQYTVLKNNMLREIDPNGDILCEFIIENDISIHQNLIPDSDNVSKDEKYLDISFIPQFKCCIDCNPTTIKLNKKMAVSDVKVLIWKIYKIQKNESLEYIFVNNKNKIKIEGYSDSHSLSDLGIETNGKIYIQDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW75</accession>
    <name>Q5CW75_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DP-fucose transporter with 9 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_1370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627044.1">
        <property type="nucleotide sequence ID" value="XM_627044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW75"/>
    <dbReference type="FunCoup" id="Q5CW75">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="GeneID" id="3374514"/>
    <dbReference type="KEGG" id="cpv:cgd8_1370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1370"/>
    <dbReference type="InParanoid" id="Q5CW75"/>
    <dbReference type="OMA" id="WVRYQER"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="236"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="329"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="363"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="390"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="111"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="428" mass="49149" checksum="202CF05E06B7BC7F" modified="2005-04-12" version="1">MIELSLGKPSPERGGDNSLISFQKYYEFEKDLTINSHENNNTENYDISNNQFVNVGKFLIIEDENFQNKREIVTEPVIEVRELINTELNINQPSDSFQLMKVEESITSISISITIYMIVSISIVFLNYKIFSGIIEFPIFVSWFQQLVGLAIFQILKIYKNHLRFELTEFTHFDHFEWETGRHMIPLALCFIGMVSLSNICLKHVLVSTYQVARSTTIIFNLILSYKILKQKSSIFTVASCIIVMIGFTISAFDSNTLNLNGVIYGVFSSIIQSFYSVLIKKQLNIVNNNQIQLLYYQLILSSIMFIPILIVTGEIRFFFILFDINQGIFKICLLLNFLIISGVLSILINFSTFQLIKKTNSITFNIIALLKSCIQSIGGILFLNEIVTFQSIFGTALTLFGTFMYSFNSNNRNSINSMEYQDLENRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW87</accession>
    <name>Q5CW87_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SEC24C-like component of COPII coatamer of ER-golgi vesicles</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_1250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627032.1">
        <property type="nucleotide sequence ID" value="XM_627032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW87"/>
    <dbReference type="STRING" id="353152.Q5CW87"/>
    <dbReference type="GeneID" id="3374265"/>
    <dbReference type="KEGG" id="cpv:cgd8_1250"/>
    <dbReference type="InParanoid" id="Q5CW87"/>
    <dbReference type="OMA" id="RLCKHGD"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
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        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF4">
        <property type="entry name" value="SECRETORY 24CD, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="5">
        <location>
            <begin position="313"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="6">
        <location>
            <begin position="397"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="8">
        <location>
            <begin position="687"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="7">
        <location>
            <begin position="846"/>
            <end position="903"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="82"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="82"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="170"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1150" mass="127840" checksum="58E6FA81E9172A7C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWD0</accession>
    <name>Q5CWD0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626989.1">
        <property type="nucleotide sequence ID" value="XM_626989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWD0"/>
    <dbReference type="SMR" id="Q5CWD0"/>
    <dbReference type="FunCoup" id="Q5CWD0">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWD0"/>
    <dbReference type="GeneID" id="3374524"/>
    <dbReference type="KEGG" id="cpv:cgd8_800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_800"/>
    <dbReference type="InParanoid" id="Q5CWD0"/>
    <dbReference type="OMA" id="NAEMSME"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="253"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="455"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="114"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="623"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="736"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="114"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="740"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="934" mass="105523" checksum="3E28945D7332E41C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWF6</accession>
    <name>Q5CWF6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_5290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627848.1">
        <property type="nucleotide sequence ID" value="XM_627848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWF6"/>
    <dbReference type="GeneID" id="3375843"/>
    <dbReference type="KEGG" id="cpv:cgd6_5290"/>
    <dbReference type="InParanoid" id="Q5CWF6"/>
    <dbReference type="OrthoDB" id="341624at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="105" mass="12080" checksum="5BE0AB9A0C6A885E" modified="2005-04-12" version="1">MVHNYEPESFQVSKGDIILQVMFIHNIKHHIIVSPCDGFGYTFNSPGNKVSKGKYFAAIQCKDEEKNKRTQKIKAVKDMNIVSSYISFKKKFFKGDPLFIMVESN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX62</accession>
    <name>Q5CX62_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein, 4 transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_2350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627592.1">
        <property type="nucleotide sequence ID" value="XM_627592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX62"/>
    <dbReference type="FunCoup" id="Q5CX62">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX62"/>
    <dbReference type="GeneID" id="3376183"/>
    <dbReference type="KEGG" id="cpv:cgd6_2350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2350"/>
    <dbReference type="InParanoid" id="Q5CX62"/>
    <dbReference type="OMA" id="DIWIAGA"/>
    <dbReference type="OrthoDB" id="276989at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="245"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="187"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="287" mass="32413" checksum="749E853038B943FA" modified="2007-04-03" version="1">MENGKKSFQIVVNSLISGGIAGLFVETILYPVDAIKTKMQYRSLCKNSVLFFSTRNYYRHIYSGFKYSAFGSFISSSIFFGTFHFLSNYSPQVKYKSLKTMQISLISELLSSLFRAPFEVIKQNIQVRNKSFLGHFYTNYSLFRHCLNFNKITASLIRDIPFSIIQFSLWEKLNRTGDGVLGEKCNFKDLLSGISGGISGAIAALITSPADNIRTYIFTKAKTRSSNVSILSAIKTIYGLNGIKSFYIGSFLRALWLTIGGIIYFGCYQLCNSALEKMYHSFETLPQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXG2</accession>
    <name>Q5CXG2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Alpha N-terminal protein methyltransferase 1</fullName>
            <ecNumber evidence="5">2.1.1.244</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">X-Pro-Lys N-terminal protein methyltransferase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_1210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-alanyl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54712"/>
            <dbReference type="Rhea" id="RHEA-COMP:13785"/>
            <dbReference type="Rhea" id="RHEA-COMP:13971"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138057"/>
            <dbReference type="ChEBI" id="CHEBI:138315"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>N-terminal L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-methionine = N-terminal N,N-dimethyl-L-prolyl-L-prolyl-L-lysyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54736"/>
            <dbReference type="Rhea" id="RHEA-COMP:13787"/>
            <dbReference type="Rhea" id="RHEA-COMP:13974"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138059"/>
            <dbReference type="ChEBI" id="CHEBI:138318"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>N-terminal L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-methionine = N-terminal N,N,N-trimethyl-L-seryl-L-prolyl-L-lysyl-[protein] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:54724"/>
            <dbReference type="Rhea" id="RHEA-COMP:13789"/>
            <dbReference type="Rhea" id="RHEA-COMP:13973"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:138061"/>
            <dbReference type="ChEBI" id="CHEBI:138317"/>
            <dbReference type="EC" id="2.1.1.244"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. NTM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.244" evidence="5"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627492.1">
        <property type="nucleotide sequence ID" value="XM_627492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXG2"/>
    <dbReference type="STRING" id="353152.Q5CXG2"/>
    <dbReference type="GeneID" id="3376035"/>
    <dbReference type="KEGG" id="cpv:cgd6_1210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1210"/>
    <dbReference type="InParanoid" id="Q5CXG2"/>
    <dbReference type="OMA" id="PVRMYCL"/>
    <dbReference type="OrthoDB" id="1298661at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071885">
        <property type="term" value="F:N-terminal protein N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008576">
        <property type="entry name" value="MeTrfase_NTM1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753">
        <property type="entry name" value="AD-003 - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12753:SF0">
        <property type="entry name" value="ALPHA N-TERMINAL PROTEIN METHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05891">
        <property type="entry name" value="Methyltransf_PK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016958">
        <property type="entry name" value="DUF858_MeTrfase_lik"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <position position="68"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="73"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="113"/>
            <end position="114"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00043129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016958-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="229" mass="26646" checksum="D7A9E7C21002C2F9" modified="2007-04-03" version="1">MMETDNGRILCRSEEIWEKQPSTNEGMLDGFIHIHEIDIDNSTYFIETLKKRLCMKKDELFEYGVDAGCGIGRVTPNLMKHCKKMDLNEPILKHLTVAKKNNPDCIELIHSKLQDFNPANGRYDFIWIQWALQYLSDDEFVDLLIRIRNSFDNCNETSANRTKRVVCIKDNADSYEDEVDPIDGSIIRTEESFLEIFKRANYKCILKMEQTFLPSSFKPIISFAIVPCE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXQ7</accession>
    <name>Q5CXQ7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Geranylgeranyl transferase type-2 subunit alpha</fullName>
            <ecNumber evidence="6">2.5.1.60</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Geranylgeranyl transferase type II subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_5300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5 6">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628673.1">
        <property type="nucleotide sequence ID" value="XM_628671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXQ7"/>
    <dbReference type="STRING" id="353152.Q5CXQ7"/>
    <dbReference type="GeneID" id="3372101"/>
    <dbReference type="KEGG" id="cpv:cgd7_5300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5300"/>
    <dbReference type="InParanoid" id="Q5CXQ7"/>
    <dbReference type="OMA" id="CVENINS"/>
    <dbReference type="OrthoDB" id="1658at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097354">
        <property type="term" value="P:prenylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF2">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 6 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="567" mass="67221" checksum="07697F2F06949CD7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXV2</accession>
    <name>Q5CXV2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CpFNPA, extracellular protein with a signal peptide, FN2 domain and an anthrax toxin-N-terminus like domain. starts at second Met with signal peptide following</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628628.1">
        <property type="nucleotide sequence ID" value="XM_628626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXV2"/>
    <dbReference type="STRING" id="353152.Q5CXV2"/>
    <dbReference type="GeneID" id="3372221"/>
    <dbReference type="KEGG" id="cpv:cgd7_4810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4810"/>
    <dbReference type="InParanoid" id="Q5CXV2"/>
    <dbReference type="OMA" id="NWPSEIT"/>
    <dbReference type="OrthoDB" id="441660at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.10.10">
        <property type="entry name" value="Fibronectin, type II, collagen-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.182.10">
        <property type="entry name" value="Toxin - Anthrax Protective Antigen,domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036943">
        <property type="entry name" value="FN_type2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037524">
        <property type="entry name" value="PA14/GLEYA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011658">
        <property type="entry name" value="PA14_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07691">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00758">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56988">
        <property type="entry name" value="Anthrax protective antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51820">
        <property type="entry name" value="PA14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254623" evidence="1">
        <location>
            <begin position="23"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="domain" description="PA14" evidence="2">
        <location>
            <begin position="221"/>
            <end position="388"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="712" mass="80007" checksum="639208A28DB1E5B5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXW8</accession>
    <name>Q5CXW8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628612.1">
        <property type="nucleotide sequence ID" value="XM_628610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXW8"/>
    <dbReference type="STRING" id="353152.Q5CXW8"/>
    <dbReference type="GeneID" id="3371950"/>
    <dbReference type="KEGG" id="cpv:cgd7_4640"/>
    <dbReference type="InParanoid" id="Q5CXW8"/>
    <dbReference type="OMA" id="ANTIAWM"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13672">
        <property type="entry name" value="PP2C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00331">
        <property type="entry name" value="PP2C_SIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="51"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="314" mass="35222" checksum="074FCB2766337039" modified="2005-04-12" version="1" fragment="single">IDLAKEKKNLIERMKYLPMVSSSLNSTSYNRFLSKFGSKQRPVSSKNRILLTGVYTSRNPTKPPGYENEDSCCVGTSYICVADGVGGWISQGVSSAMYSRQLVNYIETCINDYSREQKCELDKDKFIEMVNKCYENMKSSKIIGSSTLCLAYLDNNNKLHVFNLGDSKCVIYRKEEKEVIFESEIQQHNFNTPFQLGTGSIDTPYNADYMMLEGIKSGDAIIVATDGLWDNISMDKVIRIVDNNLLYEPQKIAEKLGREALQLSLNSEHISPYSMSLNNYLSQKLQSNIQSNGTFGFVSGGKPDDITVSIGVVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY59</accession>
    <name>Q5CY59_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Kelch repeats protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628521.1">
        <property type="nucleotide sequence ID" value="XM_628519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY59"/>
    <dbReference type="FunCoup" id="Q5CY59">
        <property type="interactions" value="74"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY59"/>
    <dbReference type="GeneID" id="3371939"/>
    <dbReference type="KEGG" id="cpv:cgd7_3580"/>
    <dbReference type="InParanoid" id="Q5CY59"/>
    <dbReference type="OMA" id="PSPRVGC"/>
    <dbReference type="OrthoDB" id="4447at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025183">
        <property type="entry name" value="DUF4110"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052588">
        <property type="entry name" value="Kelch_domain_protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46063:SF1">
        <property type="entry name" value="KELCH DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13422">
        <property type="entry name" value="DUF4110"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF4110" evidence="1">
        <location>
            <begin position="579"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="656" mass="76154" checksum="0ECC9D78DF167662" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYC2</accession>
    <name>Q5CYC2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Abd1p RNA (Guanine-7-methyltransferase (Cap methyltransferase))</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd7_2910</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-methionine = a 5'-end (N(7)-methyl 5'-triphosphoguanosine)-ribonucleoside in mRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:67008"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="Rhea" id="RHEA-COMP:17167"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:156461"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.1.1.56"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">mRNA processing; mRNA capping.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628458.1">
        <property type="nucleotide sequence ID" value="XM_628456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYC2"/>
    <dbReference type="STRING" id="353152.Q5CYC2"/>
    <dbReference type="GeneID" id="3372275"/>
    <dbReference type="KEGG" id="cpv:cgd7_2910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2910"/>
    <dbReference type="InParanoid" id="Q5CYC2"/>
    <dbReference type="OMA" id="TIDSEMW"/>
    <dbReference type="OrthoDB" id="10248867at2759"/>
    <dbReference type="UniPathway" id="UPA00922"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004482">
        <property type="term" value="F:mRNA 5'-cap (guanine-N7-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004971">
        <property type="entry name" value="mRNA_G-N7_MeTrfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039753">
        <property type="entry name" value="RG7MT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12189">
        <property type="entry name" value="MRNA GUANINE-7- METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03291">
        <property type="entry name" value="mRNA_G-N7_MeTrfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51562">
        <property type="entry name" value="RNA_CAP0_MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 15" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="MRNA cap 0 methyltransferase" evidence="14">
        <location>
            <begin position="326"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="205"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK90302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="667" mass="77579" checksum="F5BADFC04C60BD52" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYJ4</accession>
    <name>Q5CYJ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_2100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628386.1">
        <property type="nucleotide sequence ID" value="XM_628384.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYJ4"/>
    <dbReference type="GeneID" id="3371889"/>
    <dbReference type="KEGG" id="cpv:cgd7_2100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2100"/>
    <dbReference type="InParanoid" id="Q5CYJ4"/>
    <dbReference type="OMA" id="YEDEECQ"/>
    <dbReference type="OrthoDB" id="338622at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049916">
        <property type="entry name" value="WDR72-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44099:SF4">
        <property type="entry name" value="RABCONNECTIN-3B, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2266" mass="260573" checksum="C4A1326E3ED149D4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYL2</accession>
    <name>Q5CYL2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Coatomer SEC21 gamma subunit like (Beta adaptin)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd7_1910</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the COPG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628368.1">
        <property type="nucleotide sequence ID" value="XM_628366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYL2"/>
    <dbReference type="FunCoup" id="Q5CYL2">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYL2"/>
    <dbReference type="GeneID" id="3371794"/>
    <dbReference type="KEGG" id="cpv:cgd7_1910"/>
    <dbReference type="InParanoid" id="Q5CYL2"/>
    <dbReference type="OMA" id="DFIEDCE"/>
    <dbReference type="OrthoDB" id="6537869at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1480">
        <property type="entry name" value="Coatomer, gamma subunit, appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009028">
        <property type="entry name" value="Coatomer/calthrin_app_sub_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032154">
        <property type="entry name" value="Coatomer_g_Cpla"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017106">
        <property type="entry name" value="Coatomer_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013040">
        <property type="entry name" value="Coatomer_gsu_app_Ig-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037067">
        <property type="entry name" value="Coatomer_gsu_app_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10261:SF0">
        <property type="entry name" value="COATOMER SUBUNIT GAMMA-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16381">
        <property type="entry name" value="Coatomer_g_Cpla"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08752">
        <property type="entry name" value="COP-gamma_platf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037093">
        <property type="entry name" value="Coatomer_gamma_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55711">
        <property type="entry name" value="Subdomain of clathrin and coatomer appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="12">
        <location>
            <begin position="27"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer gamma subunit appendage Ig-like subdomain" evidence="13">
        <location>
            <begin position="675"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer subunit gamma C-terminal" evidence="14">
        <location>
            <begin position="817"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08752"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF16381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK90609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="936" mass="104802" checksum="10C2D4E4B9557F56" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYM0</accession>
    <name>Q5CYM0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UTP-monosaccharide-1-phosphate uridylyltransferase</fullName>
            <ecNumber evidence="6">2.7.7.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_1830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a monosaccharide 1-phosphate + UTP + H(+) = a UDP-monosaccharide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13205"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:140358"/>
            <dbReference type="ChEBI" id="CHEBI:140359"/>
            <dbReference type="EC" id="2.7.7.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the USP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.64" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628360.1">
        <property type="nucleotide sequence ID" value="XM_628358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYM0"/>
    <dbReference type="SMR" id="Q5CYM0"/>
    <dbReference type="STRING" id="353152.Q5CYM0"/>
    <dbReference type="GeneID" id="3371744"/>
    <dbReference type="KEGG" id="cpv:cgd7_1830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1830"/>
    <dbReference type="InParanoid" id="Q5CYM0"/>
    <dbReference type="OMA" id="HMNSICI"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051748">
        <property type="term" value="F:UTP-monosaccharide-1-phosphate uridylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06424">
        <property type="entry name" value="UGGPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF9">
        <property type="entry name" value="UDP-SUGAR PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="654" mass="72916" checksum="EFFFC8473F9A4348" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYP2</accession>
    <name>Q5CYP2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_1570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628338.1">
        <property type="nucleotide sequence ID" value="XM_628336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYP2"/>
    <dbReference type="GeneID" id="3372255"/>
    <dbReference type="KEGG" id="cpv:cgd7_1570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1570"/>
    <dbReference type="InParanoid" id="Q5CYP2"/>
    <dbReference type="OrthoDB" id="337870at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="127" mass="14624" checksum="2DFB85EB3D8C52F4" modified="2005-04-12" version="1">METSYNEETGEKNLLQLNLANRVSEKLAKTGLWKNINVKWSHNIHLHIVTAVQILFSSKQYLKLSTFIPLSDLDHIDSSFFENLQQDSKIILPYINSKISHHYVLAIVSSDDELILQSVNFDLKKIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYQ3</accession>
    <name>Q5CYQ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible phosphodiesterase/alkaline phosphatase D, of possible plant or bacterial origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_1430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628327.1">
        <property type="nucleotide sequence ID" value="XM_628325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYQ3"/>
    <dbReference type="FunCoup" id="Q5CYQ3">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYQ3"/>
    <dbReference type="GeneID" id="3372245"/>
    <dbReference type="KEGG" id="cpv:cgd7_1430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1430"/>
    <dbReference type="InParanoid" id="Q5CYQ3"/>
    <dbReference type="OMA" id="EHGFETW"/>
    <dbReference type="OrthoDB" id="10266805at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd07389">
        <property type="entry name" value="MPP_PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.70">
        <property type="entry name" value="PhoD-like phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018946">
        <property type="entry name" value="PhoD-like_MPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038607">
        <property type="entry name" value="PhoD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33987:SF1">
        <property type="entry name" value="CALCINEURIN-LIKE METALLO-PHOSPHOESTERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09423">
        <property type="entry name" value="PhoD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255090" evidence="2">
        <location>
            <begin position="20"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="417"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="domain" description="PhoD-like phosphatase metallophosphatase" evidence="3">
        <location>
            <begin position="118"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF09423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="463" mass="53028" checksum="C7F12D261624AAD6" modified="2005-04-12" version="1">MPSIFWIYLTFHLFIGVFAEDSSSEKLLKSLVFISCVDGQKQDKSGNYVSQEYWKAIQSDKPDALFWMGDSVYTKCGSPVCVSKGYLVQSNNSFYRDLLKTGLFVDGTWDDHDYGVNDGGKYVAFKDESQQLFLDFISLPKDSPRRNRKGVYSSHTFGPPGKQIKVIILDTRYHRDNYYVHERYGILSFAHLDTPFTSIFAASLRFFASIFGYGHSYQGDMLGKEQWDWLEKELSNSKALANIIISSIQVTTQYPIVEGWGHFPKSRERLFSLIKKTKPKGLFFLSGDVHWGQIFESDDSQKSLVEITSSGMTHSVSDRILDSFVISTTLPIFTGWSLNDKSPNYFIRENYGKLDFEYLCTDSKECSGIIVKATIRDLNGDIKLKKIFKFDNESNENHIEAISKIPQMIVEKSARQIFGRLCIIIVSIIWGIQIVIVFLYFILRIITSFTRLFSKNNSKAKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYU0</accession>
    <name>Q5CYU0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">G10 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_1020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BUD31 (G10) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628290.1">
        <property type="nucleotide sequence ID" value="XM_628288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYU0"/>
    <dbReference type="FunCoup" id="Q5CYU0">
        <property type="interactions" value="496"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYU0"/>
    <dbReference type="GeneID" id="3371999"/>
    <dbReference type="KEGG" id="cpv:cgd7_1020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1020"/>
    <dbReference type="InParanoid" id="Q5CYU0"/>
    <dbReference type="OMA" id="QWEVFQI"/>
    <dbReference type="OrthoDB" id="277109at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001748">
        <property type="entry name" value="BUD31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411:SF0">
        <property type="entry name" value="PROTEIN BUD31 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19411">
        <property type="entry name" value="PROTEIN BUD31-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01125">
        <property type="entry name" value="BUD31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00322">
        <property type="entry name" value="G10"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="144" mass="17020" checksum="CA3D21DD42A3CBF0" modified="2005-04-12" version="1">MVKQFTNVPIPQGWDQIKDELEKYNEMMREAENSSTKGKKKNEYLWPIYRINHLRSRFIYTKYYLDKEISRDLYEYCLDHGYADKDLIAKWKKQGYEYLCCINCISTSNTNYGTTCICRVPRDQLQDDGEDIECVNCGCNGCST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYV7</accession>
    <name>Q5CYV7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628273.1">
        <property type="nucleotide sequence ID" value="XM_628271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYV7"/>
    <dbReference type="GeneID" id="3371984"/>
    <dbReference type="KEGG" id="cpv:cgd7_840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_840"/>
    <dbReference type="InParanoid" id="Q5CYV7"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="134" mass="15367" checksum="E9670619C79BBB23" modified="2005-04-12" version="1">MSESNVSNNTENKGKNNGDDVGVYVHSESDLTSFARENINFATKDDENKPERMIKGSQSSFPTIKSTIEKIKMPAKLLQKCVDVIFHGRWKMITLNYFERFFMVYSRFVFRHSMAVIIAVTLICLFLGIGKFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYV9</accession>
    <name>Q5CYV9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">DNA 5'-3' helicase</fullName>
            <ecNumber evidence="17">5.6.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">cgd7_820</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the helicase family. RAD3/XPD subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.3" evidence="17"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628271.1">
        <property type="nucleotide sequence ID" value="XM_628269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYV9"/>
    <dbReference type="SMR" id="Q5CYV9"/>
    <dbReference type="FunCoup" id="Q5CYV9">
        <property type="interactions" value="403"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYV9"/>
    <dbReference type="GeneID" id="3372163"/>
    <dbReference type="KEGG" id="cpv:cgd7_820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_820"/>
    <dbReference type="InParanoid" id="Q5CYV9"/>
    <dbReference type="OMA" id="WQTMGIL"/>
    <dbReference type="OrthoDB" id="272481at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043139">
        <property type="term" value="F:5'-3' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045951">
        <property type="term" value="P:positive regulation of mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000135">
        <property type="entry name" value="DNA repair helicase RAD3, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000128">
        <property type="entry name" value="Putative DNA repair helicase RAD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010643">
        <property type="entry name" value="HBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013020">
        <property type="entry name" value="Rad3/Chl1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00604">
        <property type="entry name" value="rad3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06777">
        <property type="entry name" value="HBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="19" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9" id="KW-0347">Helicase</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-0539">Nucleus</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="20">
        <location>
            <begin position="8"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="19">
        <location>
            <begin position="77"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00048954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EAK90409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="841" mass="95274" checksum="5D08807D204E3078" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYX2</accession>
    <name>Q5CYX2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">O-acyltransferase WSD1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628258.1">
        <property type="nucleotide sequence ID" value="XM_628256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYX2"/>
    <dbReference type="GeneID" id="3372012"/>
    <dbReference type="KEGG" id="cpv:cgd7_680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_680"/>
    <dbReference type="InParanoid" id="Q5CYX2"/>
    <dbReference type="OMA" id="DERFLIN"/>
    <dbReference type="OrthoDB" id="619536at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045034">
        <property type="entry name" value="O-acyltransferase_WSD1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009721">
        <property type="entry name" value="O-acyltransferase_WSD1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650">
        <property type="entry name" value="O-ACYLTRANSFERASE (WSD1-LIKE) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31650:SF1">
        <property type="entry name" value="WAX ESTER SYNTHASE_DIACYLGLYCEROL ACYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06974">
        <property type="entry name" value="WS_DGAT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="24"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="domain" description="O-acyltransferase WSD1 C-terminal" evidence="3">
        <location>
            <begin position="631"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="495"/>
            <end position="513"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF06974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="779" mass="88642" checksum="71F0655D6AC1CCD4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYX5</accession>
    <name>Q5CYX5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Cyclin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628255.1">
        <property type="nucleotide sequence ID" value="XM_628253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYX5"/>
    <dbReference type="GeneID" id="3372009"/>
    <dbReference type="KEGG" id="cpv:cgd7_650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_650"/>
    <dbReference type="InParanoid" id="Q5CYX5"/>
    <dbReference type="OMA" id="MNINDVC"/>
    <dbReference type="OrthoDB" id="341796at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="664" mass="72648" checksum="4B2ABC245A1A6E83" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ04</accession>
    <name>Q5CZ04_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PDZ GRASP-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628226.1">
        <property type="nucleotide sequence ID" value="XM_628224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ04"/>
    <dbReference type="STRING" id="353152.Q5CZ04"/>
    <dbReference type="GeneID" id="3371902"/>
    <dbReference type="KEGG" id="cpv:cgd7_340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_340"/>
    <dbReference type="InParanoid" id="Q5CZ04"/>
    <dbReference type="OrthoDB" id="3318at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007583">
        <property type="entry name" value="GRASP55_65"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024958">
        <property type="entry name" value="GRASP_PDZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893">
        <property type="entry name" value="GOLGI REASSEMBLY STACKING PROTEIN GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12893:SF0">
        <property type="entry name" value="GRASP65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04495">
        <property type="entry name" value="GRASP55_65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51865">
        <property type="entry name" value="PDZ_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PDZ GRASP-type" evidence="6">
        <location>
            <begin position="160"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="422"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="509"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="673"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="673"/>
            <end position="683"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="732" mass="82473" checksum="371236648797522E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ12</accession>
    <name>Q5CZ12_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_250</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UTP25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628218.1">
        <property type="nucleotide sequence ID" value="XM_628216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ12"/>
    <dbReference type="STRING" id="353152.Q5CZ12"/>
    <dbReference type="GeneID" id="3372040"/>
    <dbReference type="KEGG" id="cpv:cgd7_250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_250"/>
    <dbReference type="InParanoid" id="Q5CZ12"/>
    <dbReference type="OMA" id="PSIFGYH"/>
    <dbReference type="OrthoDB" id="10264378at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010678">
        <property type="entry name" value="UTP25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053939">
        <property type="entry name" value="UTP25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053940">
        <property type="entry name" value="UTP25_NTPase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933">
        <property type="entry name" value="ORF PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12933:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 25 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06862">
        <property type="entry name" value="Utp25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22916">
        <property type="entry name" value="UTP25_NTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UTP25 NTP hydrolase-like" evidence="6">
        <location>
            <begin position="230"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="UTP25 C-terminal" evidence="5">
        <location>
            <begin position="563"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="340"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="340"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="355"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="752" mass="85735" checksum="EC86FD3DF6C26CA0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPL7</accession>
    <name>A3FPL7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA (guanine(46)-N(7))-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.33</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>guanosine(46) in tRNA + S-adenosyl-L-methionine = N(7)-methylguanosine(46) in tRNA + S-adenosyl-L-homocysteine</text>
            <dbReference type="Rhea" id="RHEA:42708"/>
            <dbReference type="Rhea" id="RHEA-COMP:10188"/>
            <dbReference type="Rhea" id="RHEA-COMP:10189"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74480"/>
            <dbReference type="EC" id="2.1.1.33"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.33" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388363.1">
        <property type="nucleotide sequence ID" value="XM_001388326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPL7"/>
    <dbReference type="FunCoup" id="A3FPL7">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPL7"/>
    <dbReference type="GeneID" id="3371862"/>
    <dbReference type="KEGG" id="cpv:cgd7_160"/>
    <dbReference type="InParanoid" id="A3FPL7"/>
    <dbReference type="OMA" id="LPNYFAK"/>
    <dbReference type="OrthoDB" id="47276at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008176">
        <property type="term" value="F:tRNA (guanine(46)-N7)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03055">
        <property type="entry name" value="tRNA_methyltr_TrmB_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025763">
        <property type="entry name" value="Trm8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003358">
        <property type="entry name" value="tRNA_(Gua-N-7)_MeTrfase_Trmb"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00091">
        <property type="entry name" value="tRNA (guanosine(46)-N7)-methyltransferase TrmB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417">
        <property type="entry name" value="3-DEOXY-D-MANNO-OCTULOSONIC-ACID TRANSFERASE/TRNA GUANINE-N 7 - -METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23417:SF16">
        <property type="entry name" value="TRNA (GUANINE-N(7)-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02390">
        <property type="entry name" value="Methyltransf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51625">
        <property type="entry name" value="SAM_MT_TRMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0820">tRNA-binding</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="251" mass="29377" checksum="0A07A44135C49FB1" modified="2007-04-03" version="1" fragment="single">HCNPLADNFMIHPLSPDYIDWELHYPNYYSDQEGFKKELHLNTKKYPIKYSENKILSEKSVAISKHLKILDIGCGYGGLLVWLSEHFKDKLALGLEIREKVTNYVGERILSMQQNGTGKNISVVKTNAMKYLPNYITKHQLEMIFICFPDPHFKKRNWRRRIVSYSTVPLYWYLLQEGGLIYIVTDVYDYYVWAVKVMDTYKTLFERIPDDELSSDPCVTAIKTSTEEAKKVERSNSPAYSCVYKTIPVEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPU4</accession>
    <name>A3FPU4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Myb proto-oncogene protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_2250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388323.1">
        <property type="nucleotide sequence ID" value="XM_001388286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPU4"/>
    <dbReference type="STRING" id="353152.A3FPU4"/>
    <dbReference type="GeneID" id="3375947"/>
    <dbReference type="KEGG" id="cpv:cgd6_2250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2250"/>
    <dbReference type="InParanoid" id="A3FPU4"/>
    <dbReference type="OMA" id="YYHPILH"/>
    <dbReference type="OrthoDB" id="330397at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050560">
        <property type="entry name" value="MYB_TF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614:SF25">
        <property type="entry name" value="MYB PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45614">
        <property type="entry name" value="MYB PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="2">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="1">
        <location>
            <begin position="55"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="2">
        <location>
            <begin position="59"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="398" mass="46741" checksum="43AE669107526615" modified="2007-04-03" version="1" fragment="single">MPQEPWNAEEDELLYQLVQRLGPSSWSETARLLNSTLNVNRLAKQCRERWISHVDPRIRRGDWSLSEDRFILNQQNLWGNRWADIARHLPGRTTHAVKNRYHQLQRLLNQGKTKLETILNAPLIHVVPHFLQQTNFFKDPPEKESEVGNQIRVKKAIIKKRRESISNYRCMNEKESIDQFKKNKPIYSENEVSFIQSELEVDKHYSKSNRKPVENYSRFEGFEQRQENVIKNDPDLYKQRIQTIESTCEVVPSNSEIEFSPRNFRRACLEFQQSPPGVLLASDVGIYPVTPTFTENCNNYKTNNAIEPSTCETNQDNEYISKSEFLTPSSELSECLPSKCIQPICIFNEEPSIYNEMDYRDPNWYVWNENSNVWDNNPIHRLDTGSIADPFLHSFPEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPW0</accession>
    <name>A3FPW0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative WD-40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_3610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388339.1">
        <property type="nucleotide sequence ID" value="XM_001388302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPW0"/>
    <dbReference type="STRING" id="353152.A3FPW0"/>
    <dbReference type="GeneID" id="3375964"/>
    <dbReference type="KEGG" id="cpv:cgd6_3610"/>
    <dbReference type="InParanoid" id="A3FPW0"/>
    <dbReference type="OMA" id="GPDEVMW"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051179">
        <property type="entry name" value="WD_repeat_multifunction"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857:SF8">
        <property type="entry name" value="ANGIO-ASSOCIATED MIGRATORY CELL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19857">
        <property type="entry name" value="MITOCHONDRIAL DIVISION PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="71"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="158"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="324"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="392" mass="42957" checksum="0148FBD82EE99A03" modified="2007-04-03" version="1">MPLFDVPDESSATILSIDSPICCIDIDPTRRGRILFGGCDDKAYVSNLPENPVYSSEQGTERLNLGFEKVFQGHSDTVSCVSYSTDGKYFATGGCDGTIRVYGNEVSNEGQLISILEGPSDELEFIRWHPRGPCIFGGGVDGTGWLWMAPDGRVLSVLSGHGDSITCGDFSNEGKIVCTGSLDGSVIIWNPKNGESLHKITRNSFVNNAGDSSYLEELGIVSMRSHKKNPLLAVGFTNGLFSLIQPDTGKVLSLNNRHHDSLDCIEFINHLEDPLLATGDMSGELIVWNYEYNRENFVMKNQELEHSNGVLPGITSICWGGDRNNTLIATGCLDGTIRLWDFRTGENVKILKGHKSGILSMKIVEFGFQGTNVLRMVSTGDDGRCLLWDVRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPX0</accession>
    <name>A3FPX0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin-related protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_4590</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388349.1">
        <property type="nucleotide sequence ID" value="XM_001388312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPX0"/>
    <dbReference type="STRING" id="353152.A3FPX0"/>
    <dbReference type="GeneID" id="3375974"/>
    <dbReference type="KEGG" id="cpv:cgd6_4590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4590"/>
    <dbReference type="InParanoid" id="A3FPX0"/>
    <dbReference type="OMA" id="WISCERC"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050776">
        <property type="entry name" value="Ank_Repeat/CDKN_Inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201">
        <property type="entry name" value="ANK_REP_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24201:SF16">
        <property type="entry name" value="ANKYRIN-1-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="199"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="235"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="265"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="289"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="324" mass="35371" checksum="A0D02DB912C709C7" modified="2007-04-03" version="1">MDNQQSELESTKYSESSSNTKALASLKGSLPEDCYYSADEDFQLENEEAVNTNLIAPSGRFSNSNRSNGLKTLGNSNQVYKQDNIRSQKLPSFGFENRFQDNIKGKGRTSGSIYRLDKTENEKDTCQVCELDTNSSLSVLSNSEDNISEFSILSDTDVFSLPAERQNSLILKASKIGNLQLVRQLIASPKFNANATNEKGFSSLHWASLKGHSQVVEELLNANAEPNTKNVMLCTPLHFSASNGFDEIVNKLLNAGANPNAVSALGDTPIFSAAFMGHENTVKTLLKNGADPRYKNKQGLTPKDAAESQGHSEIVKILEGACMQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPZ1</accession>
    <name>A3FPZ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388432.1">
        <property type="nucleotide sequence ID" value="XM_001388395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPZ1"/>
    <dbReference type="GeneID" id="3374651"/>
    <dbReference type="KEGG" id="cpv:cgd8_2990"/>
    <dbReference type="InParanoid" id="A3FPZ1"/>
    <dbReference type="OMA" id="TCICYAM"/>
    <dbReference type="OrthoDB" id="336859at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="180" mass="20066" checksum="A7E5D033C7B46057" modified="2007-04-03" version="1" fragment="single">SFVSYFFWSGISLLIGAIVLNSSFSNYSPKINNQAVCSASSNVIGIVSLWVVEGLSFISMCIAYSVVESYSTCQTFDNLTFSIQAMGVIVKYLPTWIRLIHVFTFCQINTLFAQISLLPECNSSGLQTTLIITSVTWWFVAIFGLICKKRIAIPPHIFDPLRPKTSFMTEIHLVLKTMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ10</accession>
    <name>A3FQ10_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_5120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388451.1">
        <property type="nucleotide sequence ID" value="XM_001388414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ10"/>
    <dbReference type="STRING" id="353152.A3FQ10"/>
    <dbReference type="GeneID" id="3374365"/>
    <dbReference type="KEGG" id="cpv:cgd8_5120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5120"/>
    <dbReference type="InParanoid" id="A3FQ10"/>
    <dbReference type="OMA" id="VGTMYFM"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="75"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="104"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="384" mass="43509" checksum="1987C9F91A45C21B" modified="2007-04-03" version="1">MSALRLDSFEFEENEEQRKGSFDGSNSLHTDWSLSSDGVSLLHKSTGVHITHEGTKGLESDYGLGDIYVSFGDFEVNPTPLGHGRSSVVFSAIHKLSGKIVAIKDIYVGDILHQSQLSAEIHSWRLTSYCPLLVQFLGAFIKPNKSVVCLVMEYMEFGTLSDILYKNLNRNLQSNETPEGVNENFLKFISIQMVDGLAYLHQNNRIHRDVKLNNILINQDGAVKISDFGISKLIDQNTTKDHNKNVSTFVGTQIYMSPERLQGKSYSFSSDIWSLGICIYELAVGTHPFKNLSLFDMVYILCEDNTENGEPLPFLEKIIKRCPLPEHLHKNPDFYAFLKGCLELDPLKRLTALQLQGLKWLNFGTCNRYEFLAWLQQIQKIDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ25</accession>
    <name>A3FQ25_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_2010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388105.1">
        <property type="nucleotide sequence ID" value="XM_001388068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ25"/>
    <dbReference type="STRING" id="353152.A3FQ25"/>
    <dbReference type="GeneID" id="3374082"/>
    <dbReference type="KEGG" id="cpv:cgd3_2010"/>
    <dbReference type="InParanoid" id="A3FQ25"/>
    <dbReference type="OMA" id="NIANNYY"/>
    <dbReference type="OrthoDB" id="186625at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002652618" evidence="3">
        <location>
            <begin position="32"/>
            <end position="864"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="195"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="518"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="571"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="702"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="734"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="302"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="302"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="341"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="864" mass="100154" checksum="285C4CE0E7B4E34A" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ40</accession>
    <name>A3FQ40_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Kinesin motor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_3090</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388120.1">
        <property type="nucleotide sequence ID" value="XM_001388083.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ40"/>
    <dbReference type="SMR" id="A3FQ40"/>
    <dbReference type="STRING" id="353152.A3FQ40"/>
    <dbReference type="GeneID" id="3373826"/>
    <dbReference type="KEGG" id="cpv:cgd3_3090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3090"/>
    <dbReference type="InParanoid" id="A3FQ40"/>
    <dbReference type="OMA" id="HIFEPAT"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF13">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KIF19 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0493">Microtubule</keyword>
    <keyword evidence="3 4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="5">
        <location>
            <begin position="3"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="93"/>
            <end position="100"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="634" mass="72182" checksum="6A0766157FB0E764" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ92</accession>
    <name>A3FQ92_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase II, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_2970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388228.1">
        <property type="nucleotide sequence ID" value="XM_001388191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ92"/>
    <dbReference type="FunCoup" id="A3FQ92">
        <property type="interactions" value="472"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ92"/>
    <dbReference type="GeneID" id="3373545"/>
    <dbReference type="KEGG" id="cpv:cgd2_2970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2970"/>
    <dbReference type="InParanoid" id="A3FQ92"/>
    <dbReference type="OMA" id="TMRQPGL"/>
    <dbReference type="OrthoDB" id="1162399at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060213">
        <property type="term" value="P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045948">
        <property type="term" value="P:positive regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04329">
        <property type="entry name" value="RNAP_II_Rpb7_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.120:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005576">
        <property type="entry name" value="Rpb7-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF4">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03876">
        <property type="entry name" value="SHS2_Rpb7-N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="S1 motif" evidence="5">
        <location>
            <begin position="82"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="178" mass="19949" checksum="E42D1BD817B70AC1" modified="2007-04-03" version="1">MFFFVELWRNISVKPSQLGPRYNEHIDDILRSQVEGQRAPPYGYVVCVIKIILKQPGRVQDSTGLIIVPVKYQAIVYRPIKGEVVDGVVESVNELGVIVDCGPLKRVFVSQSALPENMVYKSGIDGQSSRIYIDTKTQIQIKQNSQVRLRLRGVNNETLSAVAEMNSDFLGPIDDSIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQF1</accession>
    <name>A3FQF1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-fold modifier 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_2790</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388173.1">
        <property type="nucleotide sequence ID" value="XM_001388136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQF1"/>
    <dbReference type="STRING" id="353152.A3FQF1"/>
    <dbReference type="GeneID" id="3371396"/>
    <dbReference type="KEGG" id="cpv:cgd1_2790"/>
    <dbReference type="InParanoid" id="A3FQF1"/>
    <dbReference type="OrthoDB" id="284357at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005375">
        <property type="entry name" value="UFM1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15825:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03671">
        <property type="entry name" value="Ufm1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="75" mass="8042" checksum="7C9377F196019E46" modified="2007-04-03" version="1">MIITLNGQFKVSSATSAVITLEGVGINPNNTAGQIFLKHGSELQLIPRDRVGCSINSNIARNTYGKGSLFYSPIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQF9</accession>
    <name>A3FQF9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388181.1">
        <property type="nucleotide sequence ID" value="XM_001388144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQF9"/>
    <dbReference type="GeneID" id="3371388"/>
    <dbReference type="KEGG" id="cpv:cgd1_3450"/>
    <dbReference type="InParanoid" id="A3FQF9"/>
    <dbReference type="OrthoDB" id="343699at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="364" mass="42628" checksum="9BF106BCDD4B75B9" modified="2007-04-03" version="1">MAHQILSFICNESFSCNIILLDRPRPSFKLDNEDVAKNSNSNNKKGGQDENNQEDKKKKKKKKNKKKKKKHIDNEDENDEDEDGNKDDDEDNDDEDDDNEDGENEDGDDDDDDDDDEDDDDDDEEDGQVKDYKSKSKIAKHGKNKQDPEQHSDSDANSKSESGTDSDSDSDSDSDSDSDSKNKNREENEYDDDDDYCEENDYLAFKRETYRGTFESKLMDGIVKISYNTKKDEKKERRKKRKLLKVVKDNKNGNTEANSIEYKLSYHKSIEFEFDRFFFTIEHKYNTSIVKMIIFETENRSYEIRFRVDPELGRDNFYYAMIAFQGCYKSQNYDWDDHLKNGNIASIKDLIQEELEILALKGYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQI3</accession>
    <name>A3FQI3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DJ-1/PfpI domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_1650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388267.1">
        <property type="nucleotide sequence ID" value="XM_001388230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQI3"/>
    <dbReference type="FunCoup" id="A3FQI3">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQI3"/>
    <dbReference type="GeneID" id="3373360"/>
    <dbReference type="KEGG" id="cpv:cgd5_1650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1650"/>
    <dbReference type="InParanoid" id="A3FQI3"/>
    <dbReference type="OMA" id="KATCYPG"/>
    <dbReference type="OrthoDB" id="543156at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03135">
        <property type="entry name" value="GATase1_DJ-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.880:FF:000015">
        <property type="entry name" value="Protein DJ-1 homolog C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006287">
        <property type="entry name" value="DJ-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002818">
        <property type="entry name" value="DJ-1/PfpI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050325">
        <property type="entry name" value="Prot/Nucl_acid_deglycase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01383">
        <property type="entry name" value="not_thiJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094:SF12">
        <property type="entry name" value="PARKINSON DISEASE PROTEIN 7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48094">
        <property type="entry name" value="PROTEIN/NUCLEIC ACID DEGLYCASE DJ-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01965">
        <property type="entry name" value="DJ-1_PfpI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="DJ-1/PfpI" evidence="2">
        <location>
            <begin position="3"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="185" mass="19645" checksum="B8D363662EFC27E3" modified="2007-04-03" version="1" fragment="single">MPKKVLVALANGFEEIEFVTPVDILRRADLNVTIAVSGDCKRVMGAHGITIMGDKLLDEVLSEDYDLVMCPGGMDCAIKLGSDQNLLKILRETKKKGGIIASICASPVIVFEKNGLLSDVEKAVSYPSMMNELNRPDSSNAAVCVSSNVVTSQGPGTSVLFGLKLVEMLCGVEKSKLIADTIVAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQK5</accession>
    <name>A3FQK5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCAAT-box DNA binding protein subunit B</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_1720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NFYB/HAP3 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388060.1">
        <property type="nucleotide sequence ID" value="XM_001388023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQK5"/>
    <dbReference type="STRING" id="353152.A3FQK5"/>
    <dbReference type="GeneID" id="3372830"/>
    <dbReference type="KEGG" id="cpv:cgd4_1720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1720"/>
    <dbReference type="InParanoid" id="A3FQK5"/>
    <dbReference type="OrthoDB" id="386949at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016602">
        <property type="term" value="C:CCAAT-binding factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001228">
        <property type="term" value="F:DNA-binding transcription activator activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22907">
        <property type="entry name" value="HFD_NFYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003958">
        <property type="entry name" value="CBFA_NFYB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027113">
        <property type="entry name" value="Transc_fact_NFYB/HAP3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064">
        <property type="entry name" value="CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11064:SF9">
        <property type="entry name" value="NUCLEAR TRANSCRIPTION FACTOR Y SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00808">
        <property type="entry name" value="CBFD_NFYB_HMF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor CBF/NF-Y/archaeal histone" evidence="5">
        <location>
            <begin position="54"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="417" mass="48193" checksum="8F2ED19E205700EB" modified="2007-04-03" version="1">MNNEVTYKVNTPFINKINCDYVSNNRKISNDSDQIIDNYEDSELITDSESSDLSLPINNIGRMMKLSIPGSAKISRESKMLMQQISKDFIGCISSQAGVICTSNKRRVLNGEDIINALSSFGFGDYTDTLINYLNIWRDVKQSRNIKSYSNIYRSNSSQLNFNENYQIPTENSKQFYGVDQKFENNYVNKSLIDDQKPINNEYNKYFIQNNSPTNNQQITYTNLPKCMNNAVYEYVNLNIDKNINSQKYPENTIEDTNAHYSTNKSHFNTLLLSPTRSINFLNESSPDTPKSSFPPNQCGKRKRIEQEESKIENVADNIEQNIDFNAKYNMNYNIKNSTDVELIENNAFQGNKKSTINFSRNCNSLEYSYNQYKQDDIFLNKNETAFDCYFSSDLYIQEESENDSEYNAYPSGLFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPL6</accession>
    <name>Q5CPL6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ARM repeats containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625405.1">
        <property type="nucleotide sequence ID" value="XM_625405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPL6"/>
    <dbReference type="SMR" id="Q5CPL6"/>
    <dbReference type="FunCoup" id="Q5CPL6">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="3372382"/>
    <dbReference type="KEGG" id="cpv:cgd2_370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_370"/>
    <dbReference type="InParanoid" id="Q5CPL6"/>
    <dbReference type="OMA" id="CITMFEN"/>
    <dbReference type="OrthoDB" id="7537227at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="273" mass="30201" checksum="CF01D92D4D9AFD88" modified="2005-04-12" version="1">MGSTLSSGCCSGRESEEAKKLAQEKMNRSEALGDDISRFDLAYDKNDIQEFINLLSSTQPIDKLDEPMHPWAADPKTVGALAATQLAILAARDSQPELKDEIRKKGGIQGLLELLKSKEEDRIDGAIVALSFLSVNNVECCNVMFDCGVLPYLVKCMSSEIDGLRAASAQTARNIFILGLNQRKEFMRLGGITVLVSLLNPPTKNVDKPESWYTPLEAVYHIEDLIIDQNEELLEYTRAIRKCGVVEKLQILTKSNNRDVSEAAEILLARVAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPR5</accession>
    <name>Q5CPR5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">diacylglycerol kinase (ATP)</fullName>
            <ecNumber evidence="2">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_4340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625449.1">
        <property type="nucleotide sequence ID" value="XM_625449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPR5"/>
    <dbReference type="FunCoup" id="Q5CPR5">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPR5"/>
    <dbReference type="GeneID" id="3372390"/>
    <dbReference type="KEGG" id="cpv:cgd4_4340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4340"/>
    <dbReference type="InParanoid" id="Q5CPR5"/>
    <dbReference type="OMA" id="IEKHDYW"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF121">
        <property type="entry name" value="DIACYLGLYCEROL KINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="7">
        <location>
            <begin position="17"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="503" mass="56400" checksum="40CF2DB7ACC2840C" modified="2005-04-12" version="1">MGSIDLSPGSSFRSGSSITYTIFLFVNPTSGGNKASVFTKSGMDMFRISNPVSASVHIYDIRQGETGKKEGFLKVKETANSMGDNSIPLYIIAAGGDGTVMWCVDELEKTSVDFDKLVIGVIPFGTGNDFSRALNWMTILDNPFDNGLHRFRQLISDWINADIIEHDIWSVKAVVDSYGCFYKVDSYSRKKKVVNKQGRANARQSNHEFSRGIDRGSNTIATELTFRMSNYFSVGVESRIGIGFDRYRTKNAVLNKMRYALEGVKNTFRHTTPVYDIIDKCTVNTTCNKEDSDLIVSSEKVLFVTDQNAKFKSNSCTCSKGGYEFVDTQNSISEHNRQSTGHYQNSVENPSPTLMPCASLIFINIPSFASGNDIWRYCKGNCGIKFKSRRDSIENMLFEQQKMGDEIIECVSFPSAVAIGLEIAIKGMGRRVFQNKGPVRLHFKQKNSLATGRKVYFQVDGEFLIAYHPLYFDVSHSRKIKVLQGKTDRTLHSATLFNNFKSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPV3</accession>
    <name>Q5CPV3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_670</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625526.1">
        <property type="nucleotide sequence ID" value="XM_625526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPV3"/>
    <dbReference type="GeneID" id="3372467"/>
    <dbReference type="KEGG" id="cpv:cgd8_670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_670"/>
    <dbReference type="InParanoid" id="Q5CPV3"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254100" evidence="3">
        <location>
            <begin position="20"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="174"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="177"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="192"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="228" mass="26954" checksum="46198314A80689E1" modified="2005-04-12" version="1">MNTWLNFVIFLLSVFLANYKKNGIFLNNKSNIIISELCYLKFPGFSQNSKLTIENEITHWTLSNIPLNEIRILIAQLESKIEKLTAEFNKIKDNSKILKSNYDSHTCHNPNIKKQKGNRCEVCDKRANAIKRLYLQMKELASRIVKYQLKLDKCKYRKDILTGKVANEDVMYRPFTSPYSGRSQQDLDNLQMRRKQKAHAREKRRIQRLKDASRLPMNKHELYIQTQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPV5</accession>
    <name>Q5CPV5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">60S ribosomal protein L23A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="8">Iowa type II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the universal ribosomal protein uL23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87516.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625524.1">
        <property type="nucleotide sequence ID" value="XM_625524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPV5"/>
    <dbReference type="FunCoup" id="Q5CPV5">
        <property type="interactions" value="332"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPV5"/>
    <dbReference type="GeneID" id="3372478"/>
    <dbReference type="KEGG" id="cpv:cgd8_650"/>
    <dbReference type="InParanoid" id="Q5CPV5"/>
    <dbReference type="OMA" id="RLDHHKV"/>
    <dbReference type="OrthoDB" id="1267328at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000532">
        <property type="entry name" value="50S ribosomal protein L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_A">
        <property type="entry name" value="Ribosomal_uL23_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01369_B">
        <property type="entry name" value="Ribosomal_uL23_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013025">
        <property type="entry name" value="Ribosomal_uL23-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001014">
        <property type="entry name" value="Ribosomal_uL23_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005633">
        <property type="entry name" value="Ribosomal_uL23_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011118">
        <property type="entry name" value="PRK14548.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11620">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L23A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00276">
        <property type="entry name" value="Ribosomal_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03939">
        <property type="entry name" value="Ribosomal_L23eN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00050">
        <property type="entry name" value="RIBOSOMAL_L23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL23 N-terminal" evidence="7">
        <location>
            <begin position="19"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87516.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="156" mass="17550" checksum="B81DEA4303F507C1" modified="2005-04-12" version="1" fragment="single">YLLILFIGNTKASSTSATKANAKKTAQAVKNSKRSSTTKIRTRVQFYRPKTLKLQRNPKYERKSIKTQKSLDCYDIIKRPITTESAMKMVETLNTIVFLVNERANKTQIKYAVNKLYDVKVANVNTVNTFGDGKKAFVKLSPDVEAVDVASRIGII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPV6</accession>
    <name>Q5CPV6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625523.1">
        <property type="nucleotide sequence ID" value="XM_625523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPV6"/>
    <dbReference type="STRING" id="353152.Q5CPV6"/>
    <dbReference type="GeneID" id="3372464"/>
    <dbReference type="KEGG" id="cpv:cgd8_640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_640"/>
    <dbReference type="InParanoid" id="Q5CPV6"/>
    <dbReference type="OMA" id="NDIESIH"/>
    <dbReference type="OrthoDB" id="427368at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022100">
        <property type="entry name" value="WDHD1/CFT4_beta-prop_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19932:SF10">
        <property type="entry name" value="WD REPEAT AND HMG-BOX DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12341">
        <property type="entry name" value="Mcl1_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WDHD1/CFT4 second beta-propeller" evidence="2">
        <location>
            <begin position="637"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="479"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1113"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="484"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="535"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1120"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1149"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1159"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1182"/>
            <end position="1200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1230" mass="143303" checksum="38D167AE970928EE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPX1</accession>
    <name>Q5CPX1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">MRG/Alp3 like proteini with a chromodomain and an MRG domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625508.1">
        <property type="nucleotide sequence ID" value="XM_625508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPX1"/>
    <dbReference type="STRING" id="353152.Q5CPX1"/>
    <dbReference type="GeneID" id="3372453"/>
    <dbReference type="KEGG" id="cpv:cgd8_470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_470"/>
    <dbReference type="InParanoid" id="Q5CPX1"/>
    <dbReference type="OMA" id="WESICKK"/>
    <dbReference type="OrthoDB" id="124855at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.30">
        <property type="entry name" value="MRG domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008676">
        <property type="entry name" value="MRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038217">
        <property type="entry name" value="MRG_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026541">
        <property type="entry name" value="MRG_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880">
        <property type="entry name" value="MORTALITY FACTOR 4-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10880:SF15">
        <property type="entry name" value="MSL COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05712">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51640">
        <property type="entry name" value="MRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="MRG" evidence="6">
        <location>
            <begin position="141"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="329" mass="38800" checksum="6A9AC3B82321BEE0" modified="2005-04-12" version="1">MKNVEKLVQELHSHNVKDEVKFKHKIGDLVYSLWKGQLWKAIILDTSLKIHPNGWHPIYYVGYVTKHKTGSKNYYFNKDYNEWKSEALIFEIDGYTRKKSAETQKMLRNALKDQDRAIVEDMLGKLHSQQEMKISILNFNKIEVEWFEFSEMIYSVLIHDKNQISHGKLVILPKSPNIEDIFSEYIIYESNLIKKKKETSPEIEIQKLILNMLTKIFNKSLKKRLIYPSEMNQVSYFEKNITKSTKFSEIFGIEHLLRLLIILPKLIGDHISFGEYNLSLDPDEENNQPDYIIVKTIKLELIKTVNSFIDYFNNNVSKFSIGNYKSFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPZ3</accession>
    <name>Q5CPZ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625486.1">
        <property type="nucleotide sequence ID" value="XM_625486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPZ3"/>
    <dbReference type="GeneID" id="3372504"/>
    <dbReference type="KEGG" id="cpv:cgd8_230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_230"/>
    <dbReference type="InParanoid" id="Q5CPZ3"/>
    <dbReference type="OMA" id="THYSIGS"/>
    <dbReference type="OrthoDB" id="440760at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000178">
        <property type="term" value="C:exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039771">
        <property type="entry name" value="Csl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686">
        <property type="entry name" value="3'-5' EXORIBONUCLEASE CSL4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12686:SF8">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT CSL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0271">Exosome</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="225" mass="24442" checksum="7FFA729A10A3CFE6" modified="2005-04-12" version="1">MKEESVKVLIPGQPVRRIVEAKEPLYGVYMDDNGDMYASLMCREDQIGKMQVGNNEGGKAIGVVNRVLPRKGVEVRLLDRSGRGYKNEIEGVTGLIRPQDIGCWNMNSDADPNVTYASSTSGSSSGSASTGLANDHLESQASYWMNDCYRPGDVVRCSILSVVPQILLSTNSQDLGCIFAPCKSCKLGMAYPISYNAVLCKKCGTSMLRKTAKPKLDSEDGEIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ31</accession>
    <name>Q5CQ31_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein-lysine N-methyltransferase cgd5_4330</fullName>
            <ecNumber evidence="5">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_4330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="5"/>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625595.1">
        <property type="nucleotide sequence ID" value="XM_625595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ31"/>
    <dbReference type="FunCoup" id="Q5CQ31">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ31"/>
    <dbReference type="GeneID" id="3372579"/>
    <dbReference type="KEGG" id="cpv:cgd5_4330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4330"/>
    <dbReference type="InParanoid" id="Q5CQ31"/>
    <dbReference type="OMA" id="PTPSFQF"/>
    <dbReference type="OrthoDB" id="540004at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03188">
        <property type="entry name" value="Methyltr_EFM4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026635">
        <property type="entry name" value="Efm4/METTL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843:SF5">
        <property type="entry name" value="EEF1A LYSINE METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12843">
        <property type="entry name" value="PROTEIN-LYSINE N-METHYLTRANSFERASE METTL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="6">
        <location>
            <begin position="60"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="227" mass="25947" checksum="2929A88CC73E9EBC" modified="2005-04-12" version="1">MESDSTYKSKLINKNYWEEFYENELDSYNDVGYRGEEWFEDYIDAIVDWVMETGCEVQSGRVLDIGCGNGLFLIDLIRNINFSSAVGIDYIPSAIELAKKIVQEEELSDKISLYPVDLVSGKDVSKNNDNEQILELGKFEVVVDKGTYDIFVMKDEKHIYKDSVSRYLKNGSILFISSCNSTPEELCSVFDDQTNFEKLSELPHKSYSYNGIEGQVLASVAFKYIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ58</accession>
    <name>Q5CQ58_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_4040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625568.1">
        <property type="nucleotide sequence ID" value="XM_625568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ58"/>
    <dbReference type="GeneID" id="3372520"/>
    <dbReference type="KEGG" id="cpv:cgd5_4040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4040"/>
    <dbReference type="InParanoid" id="Q5CQ58"/>
    <dbReference type="OMA" id="NMENDEY"/>
    <dbReference type="OrthoDB" id="343924at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="658"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="591"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="658"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="832" mass="95896" checksum="5793FD4C24CA9AF8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ80</accession>
    <name>Q5CQ80_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuole membrane protein, VMP1 like integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625546.1">
        <property type="nucleotide sequence ID" value="XM_625546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ80"/>
    <dbReference type="FunCoup" id="Q5CQ80">
        <property type="interactions" value="68"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ80"/>
    <dbReference type="GeneID" id="3372591"/>
    <dbReference type="KEGG" id="cpv:cgd5_3820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3820"/>
    <dbReference type="InParanoid" id="Q5CQ80"/>
    <dbReference type="OMA" id="EEPYDKR"/>
    <dbReference type="OrthoDB" id="2016540at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="422"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="443" mass="50993" checksum="4EA188EC0A653325" modified="2005-04-12" version="1">MPREVSIYKSPIKTLNLALLFCYEVVCKIIVELFTKWYKHILILFGITLTIMGLSNLNEKLGELIHNYIYVNILNGIWWIGLGFLSSVGLGCGIHTGLLFLFPHVYSIITTAERYNTLNFDPRQNMWSNLLNPGDLFIVNDLGSDGSSISLFNILLKILPYAFLWGFGTALGELPPYAAAYAASKSRKNNRLRELKRRKENEEFEVQNSSSIENIGNEGFEINKELLPDDESTEDTNNDSSIKHYLMSLIKKCIVTLINKFGGYGVFILSCWPNLMFDLCGIICGHYLMNFWTFFIPLVLGKGIIKVFFQTLLLIFLFSSKFENKHVDIILWFIKKWPISKFFDKDEIYLKETIHNELIYIKKTLSNMNEQSGDPISSLNSNNISKINNNNWWEVIISKIQITSLFSWITIFVVVLFAISIINEAAKYQDEAIRNKENKVKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ81</accession>
    <name>Q5CQ81_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_3810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625545.1">
        <property type="nucleotide sequence ID" value="XM_625545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ81"/>
    <dbReference type="GeneID" id="3372590"/>
    <dbReference type="KEGG" id="cpv:cgd5_3810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3810"/>
    <dbReference type="InParanoid" id="Q5CQ81"/>
    <dbReference type="OrthoDB" id="344362at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="143"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="347" mass="38914" checksum="9A540F0C234C1032" modified="2005-04-12" version="1">MNRTKLIGKVLVFCIVLNILNLSFVTSKNTLNFKNNNNTYSLKITRRKLSRNQPKNNTENSEFSKSSNLILRKLLIDENGSKKIINSGLEDNSDLQNFTIISENGIANEGIVNHNNQTNDESSIVIFSAGKSPPKAPKKSPKSTKTVSSVTSKTTTTSTTFTVTNSTTITTTTTNGNNSTTQVITETHNVRRVQNKNEQGLSKSINNDTNSNQINQESVTNDMAQNKEDFTQIFNVIQDPEWITSNGDYYIIEFTEQNSTVPLVRLINLSMGLYNKNGNVEEAKRLISAVLGSRNLGDPDDEQDTEESDDFFGSGLFNLDEIINWDDLNFMDEMPSLLRKLNNIIWF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQA5</accession>
    <name>Q5CQA5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase subunit a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd4_1470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase 116 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625743.1">
        <property type="nucleotide sequence ID" value="XM_625743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQA5"/>
    <dbReference type="FunCoup" id="Q5CQA5">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQA5"/>
    <dbReference type="GeneID" id="3372611"/>
    <dbReference type="KEGG" id="cpv:cgd4_1470"/>
    <dbReference type="InParanoid" id="Q5CQA5"/>
    <dbReference type="OMA" id="FYLWFFL"/>
    <dbReference type="OrthoDB" id="10264220at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000220">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051117">
        <property type="term" value="F:ATPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002490">
        <property type="entry name" value="V-ATPase_116kDa_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026028">
        <property type="entry name" value="V-type_ATPase_116kDa_su_euka"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629:SF63">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11629">
        <property type="entry name" value="VACUOLAR PROTON ATPASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01496">
        <property type="entry name" value="V_ATPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001293">
        <property type="entry name" value="ATP6V0A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="473"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="518"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="601"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="634"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="700"/>
            <end position="722"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="851"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU361189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="920" mass="104815" checksum="5C19BB2B188BF631" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQK0</accession>
    <name>Q5CQK0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Deoxyhypusine hydroxylase</fullName>
            <shortName evidence="9">DOHH</shortName>
            <ecNumber evidence="9">1.14.99.29</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine dioxygenase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">Deoxyhypusine monooxygenase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 9">
            <text>[eIF5A protein]-deoxyhypusine + AH2 + O2 = [eIF5A protein]-hypusine + A + H2O</text>
            <dbReference type="Rhea" id="RHEA:14101"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="Rhea" id="RHEA-COMP:12592"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="ChEBI" id="CHEBI:91175"/>
            <dbReference type="EC" id="1.14.99.29"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
        <text evidence="9">Binds 2 Fe(2+) ions per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the deoxyhypusine hydroxylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.14.99.29" evidence="9"/>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625648.1">
        <property type="nucleotide sequence ID" value="XM_625648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQK0"/>
    <dbReference type="STRING" id="353152.Q5CQK0"/>
    <dbReference type="GeneID" id="3372735"/>
    <dbReference type="KEGG" id="cpv:cgd4_410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_410"/>
    <dbReference type="InParanoid" id="Q5CQK0"/>
    <dbReference type="OMA" id="HGDGPRC"/>
    <dbReference type="OrthoDB" id="421002at2759"/>
    <dbReference type="UniPathway" id="UPA00354"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019135">
        <property type="term" value="F:deoxyhypusine monooxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03101">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027517">
        <property type="entry name" value="Deoxyhypusine_hydroxylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004155">
        <property type="entry name" value="PBS_lyase_HEAT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697:SF5">
        <property type="entry name" value="DEOXYHYPUSINE HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12697">
        <property type="entry name" value="PBS LYASE HEAT-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13646">
        <property type="entry name" value="HEAT_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00567">
        <property type="entry name" value="EZ_HEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 9" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="6 9" id="KW-0408">Iron</keyword>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 9" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <feature type="binding site" evidence="9">
        <location>
            <position position="84"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="85"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="118"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="275"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="308"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="385" mass="43148" checksum="D047D1F73F991946" modified="2005-04-12" version="1">MVVINEITPKAMLPGCPVKPLGGGEFSSFNIYSKEKIRELLLSHDTDISSKIRCLFFGRFHGDEESAEMLSKSLDYSESVLFRHEVLYVLGQMGLKSPLTRLYEILADETEHPMVRHEAGEAIAAIGDDESLEIVEKYLNDNSPAVRETCYLAAHSLRLKREKRLKESNKQDIDTNISNINAFNTRDPTPPKSSCEVSHIESLASDLLNEDLQLEKRYAALFALRNILTGIIDSNQRKSLSDQYDQQIDNDKVHFIAGEIAKAMEIDKSSAVFRHECAFVLGQIQVISTADTLSRVLSNQSEESMVRHEAAFALGSVGSNDPRCSENLEKMDKLCTKKELDRVRKLSIETLLKYSNDLDIIVAESCIVGLQTIMDETGSLDILLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQY2</accession>
    <name>Q5CQY2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625870.1">
        <property type="nucleotide sequence ID" value="XM_625870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQY2"/>
    <dbReference type="FunCoup" id="Q5CQY2">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="3373000"/>
    <dbReference type="KEGG" id="cpv:cgd4_2850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2850"/>
    <dbReference type="InParanoid" id="Q5CQY2"/>
    <dbReference type="OMA" id="TEDYNCK"/>
    <dbReference type="OrthoDB" id="338088at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="685" mass="80901" checksum="5FD4E0CBAAE3A87A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQZ0</accession>
    <name>Q5CQZ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">11 transmembrane domain protein, possible aa transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_2770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625862.1">
        <property type="nucleotide sequence ID" value="XM_625862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQZ0"/>
    <dbReference type="STRING" id="353152.Q5CQZ0"/>
    <dbReference type="GeneID" id="3372834"/>
    <dbReference type="KEGG" id="cpv:cgd4_2770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2770"/>
    <dbReference type="InParanoid" id="Q5CQZ0"/>
    <dbReference type="OMA" id="NENEDCA"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="118"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="162"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="192"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="311"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="488"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="525"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="19"/>
            <end position="551"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="557" mass="61851" checksum="BEE51B46E472FB0C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR05</accession>
    <name>Q5CR05_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Spindle assembly abnormal protein 6 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625847.1">
        <property type="nucleotide sequence ID" value="XM_625847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR05"/>
    <dbReference type="STRING" id="353152.Q5CR05"/>
    <dbReference type="GeneID" id="3372846"/>
    <dbReference type="KEGG" id="cpv:cgd4_2610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2610"/>
    <dbReference type="InParanoid" id="Q5CR05"/>
    <dbReference type="OMA" id="RQHITFR"/>
    <dbReference type="OrthoDB" id="49058at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.210.20">
        <property type="entry name" value="Spindle assembly abnormal protein 6, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032396">
        <property type="entry name" value="SAS-6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038558">
        <property type="entry name" value="SAS-6_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34230">
        <property type="entry name" value="ASSEMBLY ABNORMAL PROTEIN 6, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34230:SF2">
        <property type="entry name" value="SPINDLE ASSEMBLY ABNORMAL PROTEIN 6 N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16531">
        <property type="entry name" value="SAS-6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spindle assembly abnormal protein 6 N-terminal" evidence="1">
        <location>
            <begin position="37"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF16531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="227" mass="26593" checksum="9467D5B12FBBB244" modified="2005-04-12" version="1">MINKEKRIDQERIFLDSFDYSELEKADPTLSGGFNVVYRRTCPVEIRLIDSDDVEEIGTTENINFRVMIKGAKSLPDTIRFEITCDNDLFLFYTRDFSASDFNELKVVQNLVCDYSDFTETFCRIVNNTIQDQLGCFAKFCLRVDGSAKLTFIQVMEYKFLELLSIDFQQTPEEIIRNSISFRYSFMKSKVALMEGRFLEISNLLSIRNPNLLHYLQKNSNCIRNKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR41</accession>
    <name>Q5CR41_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Clathrin/coatomer adaptor adaptin-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_2210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87940.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625811.1">
        <property type="nucleotide sequence ID" value="XM_625811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR41"/>
    <dbReference type="STRING" id="353152.Q5CR41"/>
    <dbReference type="GeneID" id="3372984"/>
    <dbReference type="KEGG" id="cpv:cgd4_2210"/>
    <dbReference type="InParanoid" id="Q5CR41"/>
    <dbReference type="OMA" id="IHAIKMT"/>
    <dbReference type="OrthoDB" id="29308at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="53"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="827"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="827"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="847"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87940.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="910" mass="104162" checksum="40E14363A5F96A1B" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRB3</accession>
    <name>Q5CRB3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Biotin-protein ligase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_3490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626273.1">
        <property type="nucleotide sequence ID" value="XM_626273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRB3"/>
    <dbReference type="GeneID" id="3373100"/>
    <dbReference type="KEGG" id="cpv:cgd5_3490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3490"/>
    <dbReference type="InParanoid" id="Q5CRB3"/>
    <dbReference type="OMA" id="NINDMSG"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019197">
        <property type="entry name" value="Biotin-prot_ligase_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09825">
        <property type="entry name" value="BPL_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254432" description="Biotin-protein ligase N-terminal domain-containing protein" evidence="1">
        <location>
            <begin position="24"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Biotin-protein ligase N-terminal" evidence="2">
        <location>
            <begin position="138"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="297" mass="32514" checksum="F073D1BC9071C3DF" modified="2005-04-12" version="1">MRFYVTLISVIAALLCTSTSVLSMEHKSLRQSKTELFTKVGLFIEGFTLESVARTKLAIEKGFEQVEIVDLTLGDLKALPASHGIQLFVAPSEMSTGLESVAKEGMAIISDFVLKGSFLFSQMDSSSTLCKEFDYEGVKTSNSPFIYDGVCVGPITKSGPMETECRAITAQVDSRARMVTYNNLFVHRGFYFVDAESKKNCKILASATPRDNSETLIEFRSNTNAKAIIVACKHGSGAAILSGVQLDQNAAFLKSYIARHPENTHVKSVTESLSDVTEFTKSLLHFVVMMKVTATLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRE9</accession>
    <name>Q5CRE9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_3060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626237.1">
        <property type="nucleotide sequence ID" value="XM_626237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRE9"/>
    <dbReference type="GeneID" id="3373249"/>
    <dbReference type="KEGG" id="cpv:cgd5_3060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3060"/>
    <dbReference type="InParanoid" id="Q5CRE9"/>
    <dbReference type="OMA" id="DHESFAM"/>
    <dbReference type="OrthoDB" id="340288at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="311" mass="36433" checksum="90A6612573C2F40D" modified="2005-04-12" version="1">MAMEGEPIHSKIRELTRAIEKNQDLLSDPQKRSEYKEYVLKDDEFFENIGESDYRTFSLLCEFGSVKALVNEKRYNKIYKQSQNSLLRNILKNWKDKYMNKKPQQNDTSEEDSDFPTENDDEFVKLNWNGWFNDHFTINVFPINNIKFNTLQGLLSQETHSEPPAKRVRVVNNRTKNTISKETKTLEDEDVHDTQNIQILQEFKNKLLNKIQEKDINNEGIELWELVLEKDQQYGFANTCFNLFSLLSLLKDSLISITSPNTVIKNNTSKDKKVLVFLANSSISSDFEKNTGIISNFTYHAWQNLCKRYGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRH8</accession>
    <name>Q5CRH8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large protein containing a signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626208.1">
        <property type="nucleotide sequence ID" value="XM_626208.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373234"/>
    <dbReference type="KEGG" id="cpv:cgd5_2720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2720"/>
    <dbReference type="InParanoid" id="Q5CRH8"/>
    <dbReference type="OMA" id="WITENSR"/>
    <dbReference type="OrthoDB" id="340360at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264:SF3">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="492"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="492"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1939" mass="224009" checksum="3DD216C60C4205CE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRJ1</accession>
    <name>Q5CRJ1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_2580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626195.1">
        <property type="nucleotide sequence ID" value="XM_626195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRJ1"/>
    <dbReference type="GeneID" id="3373160"/>
    <dbReference type="KEGG" id="cpv:cgd5_2580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2580"/>
    <dbReference type="InParanoid" id="Q5CRJ1"/>
    <dbReference type="OrthoDB" id="4507at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21385:SF0">
        <property type="entry name" value="RE51073P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21385">
        <property type="entry name" value="ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254160" description="C2H2-type domain-containing protein" evidence="2">
        <location>
            <begin position="25"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="233" mass="26976" checksum="23DC961888301AD1" modified="2005-04-12" version="1">MAHTKTFHLALILFFLTKISQIYCDINCSRQVSRRVSHAIRKLLKDKKDISKHLLPECAFNQEHHIFNYEEKINIVYPTGERQCGFCGEIFQDEKTYDQHMGKSHPSLQSGEFYCAEKLCTIFGECGEPARVQACSSAAQDESLLDFCRKTIKSCFSEDNKDSKLIGIELNQKLCNKERILEVNRCIEKKVQQSNANVIEFLFHHFSKALLIVIMLSTFFISYKINLHVNKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRR1</accession>
    <name>Q5CRR1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SMART 2xt_SNARE domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_1810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SNAP-25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626125.1">
        <property type="nucleotide sequence ID" value="XM_626125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRR1"/>
    <dbReference type="FunCoup" id="Q5CRR1">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRR1"/>
    <dbReference type="GeneID" id="3373005"/>
    <dbReference type="KEGG" id="cpv:cgd5_1810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1810"/>
    <dbReference type="InParanoid" id="Q5CRR1"/>
    <dbReference type="OMA" id="WWKNINS"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305">
        <property type="entry name" value="SYNAPTOSOMAL ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19305:SF9">
        <property type="entry name" value="SYNAPTOSOMAL-ASSOCIATED PROTEIN 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="139"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="10"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009480"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="204" mass="23623" checksum="CAC530379E275EB1" modified="2005-04-12" version="1">MENIYNEEKQDSGKQEIAELQNKCKKALKNTLKIAADANEISMYSATKLNEQTEQLYKIEDETEKIKDNLDKTEHAINSLKNPLLFWFKGLFRQNEPTHIRPAFANFQKNKEIQNEGRCQIISDLPKERNSDIKNDGLFQFNEEIDEGLDQIGDMLKEMHNRAISMNTALKNQGGILNNIDTNINSNNSRMKDQRTKLEKFIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRT4</accession>
    <name>Q5CRT4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Roadblock/LAMTOR2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_1550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626102.1">
        <property type="nucleotide sequence ID" value="XM_626102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRT4"/>
    <dbReference type="FunCoup" id="Q5CRT4">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRT4"/>
    <dbReference type="GeneID" id="3373093"/>
    <dbReference type="KEGG" id="cpv:cgd5_1550"/>
    <dbReference type="InParanoid" id="Q5CRT4"/>
    <dbReference type="OMA" id="IVKCANM"/>
    <dbReference type="OrthoDB" id="9985637at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.30">
        <property type="entry name" value="Dynein light chain 2a, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10779">
        <property type="entry name" value="DYNEIN LIGHT CHAIN ROADBLOCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103196">
        <property type="entry name" value="Roadblock/LC7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="94" mass="10579" checksum="C50D3E644F8A49E5" modified="2005-04-12" version="1" fragment="single">NDLNETLSRIKGKKGVVGIIILRSDNMTPLISTFDKKTSRNYTDCIREIVKCANMFGAHGSNNIQLIRLHFKSQIVLIAPDKNFTFLAVQDTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRU6</accession>
    <name>Q5CRU6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626090.1">
        <property type="nucleotide sequence ID" value="XM_626090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRU6"/>
    <dbReference type="GeneID" id="3373285"/>
    <dbReference type="KEGG" id="cpv:cgd5_1430"/>
    <dbReference type="InParanoid" id="Q5CRU6"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254175" evidence="1">
        <location>
            <begin position="22"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="128" mass="15177" checksum="178838F4AA4E8E21" modified="2005-04-12" version="1">MIPKFNLVFLILFILIKIEYKRLIVMAKDSSDKIAKRFFVNQDKPQWQRTQAPREEIAIICHILSLGPIECIKYNEREFDGANPGHEEYMGKENLITIMTTINFFRVFYPIWNVWCGCSCSYKIEFSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRV0</accession>
    <name>Q5CRV0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626086.1">
        <property type="nucleotide sequence ID" value="XM_626086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRV0"/>
    <dbReference type="FunCoup" id="Q5CRV0">
        <property type="interactions" value="231"/>
    </dbReference>
    <dbReference type="GeneID" id="3373288"/>
    <dbReference type="KEGG" id="cpv:cgd5_1390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1390"/>
    <dbReference type="InParanoid" id="Q5CRV0"/>
    <dbReference type="OMA" id="CRNVVPE"/>
    <dbReference type="OrthoDB" id="407630at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006797">
        <property type="entry name" value="PRELI/MSF1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037365">
        <property type="entry name" value="Slowmo/Ups"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11158">
        <property type="entry name" value="MSF1/PX19 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04707">
        <property type="entry name" value="PRELI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50904">
        <property type="entry name" value="PRELI_MSF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PRELI/MSF1" evidence="1">
        <location>
            <begin position="1"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="228" mass="26894" checksum="09DD011D4AFA2C43" modified="2005-04-12" version="1">MVFFSKKHLYPFSWENVVNAFWNKYPNDLQSHVKRVDIVNIYFDEKDKVLYTKRLFSLKYNLPKLLERIIGSSLSGLAIEESKCDFNEKRLISNGTNHSFNNFFLIRETCGFSSNNECPESTLYMQNMAFKLFGEKNKLNRMNKLFESTVVNLLNEKSQSGIKVMYNKIDQIKSMLNNKYEIKGSENKSTSYKLNGLSKTYEKKNFKFFEKINKILLVPYKAIFHNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRY5</accession>
    <name>Q5CRY5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_1000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626051.1">
        <property type="nucleotide sequence ID" value="XM_626051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRY5"/>
    <dbReference type="GeneID" id="3373126"/>
    <dbReference type="KEGG" id="cpv:cgd5_1000"/>
    <dbReference type="InParanoid" id="Q5CRY5"/>
    <dbReference type="OrthoDB" id="339318at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="703" mass="79366" checksum="775FC889F25C45F7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRZ3</accession>
    <name>Q5CRZ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein with conserved domain that is fused in vertebrates to neuralized domain repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626043.1">
        <property type="nucleotide sequence ID" value="XM_626043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRZ3"/>
    <dbReference type="GeneID" id="3373132"/>
    <dbReference type="KEGG" id="cpv:cgd5_910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_910"/>
    <dbReference type="InParanoid" id="Q5CRZ3"/>
    <dbReference type="OrthoDB" id="49113at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="361" mass="42190" checksum="876444880B315CBE" modified="2005-04-12" version="1">MQKASERSKLFDFYEQIFINNNLNSEKKTSNSANILNLKYKIDEKSSQKNFNLSKGCQCINNTDQLIELLNLKSYLDFEKKTCCRDHCKINESDPNSGVELNGWSRYPLKISKFEEENVKNWDLSYHGTTHKAIKSILKDKRLVIPNNKTVHIRKGHIPNQYFIFTSPSLLYASFGLYSAPFKIKESKKWWQIVVEIVQKPNSYVKEWETSGLGNYEFDKYIGNYELEWKSDQEMGNLIKAVLVREIRNVEPPICQYPVGTYFLHDDSWWYQPYDGSTPFCPNEISSNCDCYLKRGARIKGGTCPVVNYRFSQLKKRQICASVEKYLRSLSILKLNENESLNNFEKEISQKIPIKTSQTYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS09</accession>
    <name>Q5CS09_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ethanolamine kinase</fullName>
            <ecNumber evidence="3">2.7.1.82</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 1/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.82" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626027.1">
        <property type="nucleotide sequence ID" value="XM_626027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS09"/>
    <dbReference type="FunCoup" id="Q5CS09">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS09"/>
    <dbReference type="GeneID" id="3373164"/>
    <dbReference type="KEGG" id="cpv:cgd5_720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_720"/>
    <dbReference type="InParanoid" id="Q5CS09"/>
    <dbReference type="OMA" id="CAFDIAN"/>
    <dbReference type="OrthoDB" id="10267235at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05157">
        <property type="entry name" value="ETNK_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF66">
        <property type="entry name" value="ETHANOLAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00037883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="443" mass="51262" checksum="8181911875F9D8D8" modified="2005-04-12" version="1">MTWNTNLLESKLKEAERVSWKLFKTGICKCCDPDKLIKSKILTGGLSNILVLISISIDSFCEDMKRVNKNILISNLKVRFYSEERKIFVNEKREQLIQNLLANAGIIKPILQYFQGGQIEEFVEGRTLEVEDLRNRKTYIQVAKKIASLHSIKISQDILENICLEYNSEIHQSLGDVPYSESNKSISILWPTLDKWASLSEKSFKLNHGKYQTCINFEKLRILICKLKKSLYSDTLSKLTCSIVVSHSDLLPGNIIETLNNNYTFIDYEFSGTMECVFDIGNHLCEWAGFTCNWEYLPNDETISEFLKYYIAGLSSNKFKENRFESKKDEAVSNTNLGIKKDELENNYQCINHEKKEAFEFENSDSSLTIKSYVKAVKICMVISNIFWGLWGICKSDIRSNNSSNSVFDYRSYAYRKLESINTQPYFRDILKGIDQDIEFPVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS56</accession>
    <name>Q5CS56_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625980.1">
        <property type="nucleotide sequence ID" value="XM_625980.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373200"/>
    <dbReference type="KEGG" id="cpv:cgd5_160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_160"/>
    <dbReference type="InParanoid" id="Q5CS56"/>
    <dbReference type="OMA" id="ESISTEH"/>
    <dbReference type="OrthoDB" id="344214at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="55"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="110"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="129"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="161" mass="18235" checksum="F53DB547DC59DABA" modified="2005-04-12" version="1">MTNSNNENNNKSKTEEIEEKTIQTTNNTRTADIWNLYGMIDADPLSSTESDDINYVSMVAIGAATSAALWKAYFYRPEEMDDFTTYSMYIVTVLTIVGAXYVISSIRKREKEEQLRSSEANQTSSSDKNSSDSEKSKETTVNNEDSKISSNNIRRRKNRAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS72</accession>
    <name>Q5CS72_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Insulinase-like peptidase, telomeric protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628195.1">
        <property type="nucleotide sequence ID" value="XM_628195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS72"/>
    <dbReference type="STRING" id="353152.Q5CS72"/>
    <dbReference type="GeneID" id="3371507"/>
    <dbReference type="KEGG" id="cpv:cgd1_3840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3840"/>
    <dbReference type="InParanoid" id="Q5CS72"/>
    <dbReference type="OrthoDB" id="339748at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1031" mass="118653" checksum="E3034273F5FD7D27" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS92</accession>
    <name>Q5CS92_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dynein light intermediate chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd1_3630</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628175.1">
        <property type="nucleotide sequence ID" value="XM_628175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS92"/>
    <dbReference type="GeneID" id="3371523"/>
    <dbReference type="KEGG" id="cpv:cgd1_3630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3630"/>
    <dbReference type="InParanoid" id="Q5CS92"/>
    <dbReference type="OMA" id="NANTISC"/>
    <dbReference type="OrthoDB" id="27603at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008467">
        <property type="entry name" value="Dynein1_light_intermed_chain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022780">
        <property type="entry name" value="Dynein_light_int_chain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12688:SF0">
        <property type="entry name" value="DYNEIN LIGHT INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05783">
        <property type="entry name" value="DLIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-0243">Dynein</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-0505">Motor protein</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="300"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="557"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="722"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="327"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="339"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="563"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="595"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="648"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="688"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="722"/>
            <end position="733"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="745" mass="80351" checksum="3FCB508246E93C78" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSM3</accession>
    <name>Q5CSM3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cytoplasmic tRNA 2-thiolation protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_2090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628044.1">
        <property type="nucleotide sequence ID" value="XM_628044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSM3"/>
    <dbReference type="GeneID" id="3371685"/>
    <dbReference type="KEGG" id="cpv:cgd1_2090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2090"/>
    <dbReference type="InParanoid" id="Q5CSM3"/>
    <dbReference type="OMA" id="HYMSLAS"/>
    <dbReference type="OrthoDB" id="25129at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016783">
        <property type="term" value="F:sulfurtransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019407">
        <property type="entry name" value="CTU2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20882:SF14">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="42746" checksum="B44A6F211AE94C70" modified="2005-04-12" version="1">METIFCYKCKSKKAEVNTRFLSCIDCFNSYIEGNVRKEIRTGPIERLKELKSSYQSKKPLKSELYVALGFGFYSHALLNLLSVIPKTGKRPDYSIKSFINVDTSPLVNRDPSEYYESLNACIQSIYSHNAYSNGFQIIPKLQIIPFCSSIIRGDTQSDKEKRQAILDEIKFHIDRGTDHIKLLIQLIIFKDIKHYLDSIDHSRQKCLVIASTSESLGSESIQYMTLASGVHIKSIYEHLDFRFHTEKSSLLFIRPLRNLTSKEVMLYWKFNISKILNSSIGAELSLNKSPIEYEISKFILSQSEKICNITNIFMKLNENNNEQHKYSIYVKENIFCKLCGIIHNKVIDNKYCQMCYSLLKILNLTGKVID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSP7</accession>
    <name>Q5CSP7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628020.1">
        <property type="nucleotide sequence ID" value="XM_628020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSP7"/>
    <dbReference type="GeneID" id="3371664"/>
    <dbReference type="KEGG" id="cpv:cgd1_1810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1810"/>
    <dbReference type="InParanoid" id="Q5CSP7"/>
    <dbReference type="OMA" id="DNFENNK"/>
    <dbReference type="OrthoDB" id="343017at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="673" mass="78229" checksum="E67B22C5EA15D1AD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSQ6</accession>
    <name>Q5CSQ6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Serine/threonine-protein phosphatase PGAM5, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Serine/threonine-protein phosphatase Pgam5, mitochondrial</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_1710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628011.1">
        <property type="nucleotide sequence ID" value="XM_628011.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSQ6"/>
    <dbReference type="FunCoup" id="Q5CSQ6">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSQ6"/>
    <dbReference type="GeneID" id="3371637"/>
    <dbReference type="KEGG" id="cpv:cgd1_1710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1710"/>
    <dbReference type="InParanoid" id="Q5CSQ6"/>
    <dbReference type="OMA" id="QLPLFAW"/>
    <dbReference type="OrthoDB" id="2118094at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090141">
        <property type="term" value="P:positive regulation of mitochondrial fission"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07067">
        <property type="entry name" value="HP_PGM_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013078">
        <property type="entry name" value="His_Pase_superF_clade-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051021">
        <property type="entry name" value="Mito_Ser/Thr_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935">
        <property type="entry name" value="PHOSPHOGLYCERATE MUTASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20935:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE PGAM5, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00300">
        <property type="entry name" value="His_Phos_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00855">
        <property type="entry name" value="PGAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00039765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="297" mass="33587" checksum="BCBC19D45CD9A072" modified="2005-04-12" version="1">MLASIFSSLRKYSFLARANNFQLKERKMNFSFLFNKKTLASSKLYRFAKFSTSSIILSGIVTIYSFVNFGYYLKDSINWNPNWDGNYKHENKRNGKVVSDNARKWHQNILVRHAQYITSAAKDEEKVLTDLGKEQAEETGKYLSQQYGEKVNAIYHSNLTRAKETATIISKYFPGVKLIEDPNLAEGVPIAPSPSVSGFKPTIGEIVKDKERIDNAFNTYFSKNGKSFGDNVDIIVCHGNVIRYMFCKGLQYPTSGWLRLNHLNCGVTRMSISTDSLVICSGLGDGGHLRPSIHTYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSU9</accession>
    <name>Q5CSU9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec14 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627968.1">
        <property type="nucleotide sequence ID" value="XM_627968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSU9"/>
    <dbReference type="STRING" id="353152.Q5CSU9"/>
    <dbReference type="GeneID" id="3371596"/>
    <dbReference type="KEGG" id="cpv:cgd1_1240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1240"/>
    <dbReference type="InParanoid" id="Q5CSU9"/>
    <dbReference type="OMA" id="INTRYRM"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46818:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_125, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46818">
        <property type="entry name" value="DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="213"/>
            <end position="376"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="461" mass="52562" checksum="724AD6A7D221081C" modified="2005-04-12" version="1">MADQDSGEVLGPCLSKEEERISEIIDAFKDTSILEKSHSESESVSFTSALEESDMELVEELDPVSSRAFLDRKMNSLPQLQETVGNLEITKSTSMTNSGNAKPIQRNIGGVEIYSALNPFSTTLSCLLIEPSESDIIEDEIRYIYLNQILSENEQLYLAKLRKYAKNHGYKFPHSIWIQALRFLASSRFHVQTALEMMLSNHEFRIKELPISEKDVMNDLKVGAIYWHGKDIKCRPILIVKLAKLDTFVGEIERIQKLLCFCLEFFLKYLQVAGRVENWNVIIDLAGKGITDLPIQVLKSVLSLVNTRYRMRLYRMFIVNCPKFINVVSNALVAAIPGSSVRKIRFIDESYSDEITSLVPLEQLEESYGGKCPNLTENFYPFRFYPMNELDQKFPNIHAIIPPEYISGISIEIPPRFDLTKLPWLSQIPNANFTKKTAEQLSQILGTEIKPKITTEDITNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSW4</accession>
    <name>Q5CSW4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627953.1">
        <property type="nucleotide sequence ID" value="XM_627953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSW4"/>
    <dbReference type="STRING" id="353152.Q5CSW4"/>
    <dbReference type="GeneID" id="3371367"/>
    <dbReference type="KEGG" id="cpv:cgd1_1080"/>
    <dbReference type="InParanoid" id="Q5CSW4"/>
    <dbReference type="OMA" id="PRDNIPR"/>
    <dbReference type="OrthoDB" id="336047at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886:SF53">
        <property type="entry name" value="ALPHA_BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42886">
        <property type="entry name" value="RE40534P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="36"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="220" mass="25075" checksum="DD8410D29BB9888A" modified="2005-04-12" version="1" fragment="single">SSLSTYRGKFFIESGKNHLLSAVSTIHDYESPQTAIICHGLFSSKENRLCQTIAKHLSINVVRFDFHGNGESQGADSWSFGDYHGEVNDDLRKVVEFLRNKGLEIKAIIGHSRGGVETLMYSWMYDDVDIIISISARFDLANSIITRFISDEQYEKLKNNELESVEIIPRDNIPRKITLECINKRNLVDYNMLKTVKNTKYFLLIHGTKDDIVPVQVSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSY8</accession>
    <name>Q5CSY8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein disulfide isomerase, signal peptide plus possible ER retention motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627929.1">
        <property type="nucleotide sequence ID" value="XM_627929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSY8"/>
    <dbReference type="SMR" id="Q5CSY8"/>
    <dbReference type="FunCoup" id="Q5CSY8">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSY8"/>
    <dbReference type="GeneID" id="3371531"/>
    <dbReference type="KEGG" id="cpv:cgd1_800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_800"/>
    <dbReference type="InParanoid" id="Q5CSY8"/>
    <dbReference type="OMA" id="FTPWCIN"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254215" evidence="2">
        <location>
            <begin position="23"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="90"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="498"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="657" mass="74796" checksum="3740125C2C9715A4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT52</accession>
    <name>Q5CT52_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane associated protein with 11 transmembrane domains regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_20</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627865.1">
        <property type="nucleotide sequence ID" value="XM_627865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT52"/>
    <dbReference type="GeneID" id="3371443"/>
    <dbReference type="KEGG" id="cpv:cgd1_20"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_20"/>
    <dbReference type="InParanoid" id="Q5CT52"/>
    <dbReference type="OMA" id="REICINN"/>
    <dbReference type="OrthoDB" id="344229at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="274"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="306"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="338"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="376"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="438" mass="51639" checksum="F7C76D06C6B640CC" modified="2005-04-12" version="1">MCSNIYRENNKKNESLKDFLESQLTIQIGISLWIIFFFHCSHIVMYNGVIFPVAIDVNATLSYYTVDLLNIAIPLYLYSHGWELVKIRVMNFQYYLNHHLKYLLPGFVYWLLIFVIKNFDKLELSTQSNFSLPNEDWSWSAPYRFGLISIFIYHFLVAMVMYPIICLIKKCYNCYESCEYEYGIISNSDLITNVDKDFSENEISKRFVASQNIYINYGSSNSNLPYIISNVIIYFLIINIFFYFSYSANLYILYTLFYSSIFLIYSLKFIQKEISISGICIFMNIIYISLYKYLTSGIPNSAFNNGAVFFNTFFLFLVYYFTGFTMAFTDSLLKIQKYYLDLLFLLPIIYNFLSIPNRTLMYSPLIFPISFQEGDQTRVIISTWIGIIFTISIVLRFCRKRSIEYTKIIIKKIPYILIISVTVISFIYERARQIANGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT90</accession>
    <name>Q5CT90_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_3970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626579.1">
        <property type="nucleotide sequence ID" value="XM_626579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT90"/>
    <dbReference type="STRING" id="353152.Q5CT90"/>
    <dbReference type="GeneID" id="3373414"/>
    <dbReference type="KEGG" id="cpv:cgd2_3970"/>
    <dbReference type="InParanoid" id="Q5CT90"/>
    <dbReference type="OMA" id="RAYDEHY"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033">
        <property type="entry name" value="RNA-BINDING (RRM/RBD/RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48033:SF10">
        <property type="entry name" value="RNA-BINDING PROTEIN SQUID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23085">
        <property type="entry name" value="RRM_PARP14_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="85"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="199" mass="22588" checksum="A869EC6381A6A9E6" modified="2005-04-12" version="1" fragment="single">YYLLILLFLKDQLIRHFEKFGNVENCQYIQVMNFAIITFSEKGVTDNALRSPHVIMGREVNCRLYCDKLEDLAGENSQGTMFRTEKIFVGNLPTTCSQDILRKYFEQFGQISDCVMMCDKKSGIGRGFGFVTFTSTSVVDEIIRAYDEHYIDGQWVEVKRASPENALRGGNMSCNGISSLNATNLSTREKNNTSLLIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTI3</accession>
    <name>Q5CTI3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative biotin-(Acetyl-CoA carboxylase) ligase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_2890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the biotin--protein ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626486.1">
        <property type="nucleotide sequence ID" value="XM_626486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTI3"/>
    <dbReference type="FunCoup" id="Q5CTI3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTI3"/>
    <dbReference type="GeneID" id="3373466"/>
    <dbReference type="KEGG" id="cpv:cgd2_2890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2890"/>
    <dbReference type="InParanoid" id="Q5CTI3"/>
    <dbReference type="OMA" id="MLIIREA"/>
    <dbReference type="OrthoDB" id="10250105at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004077">
        <property type="term" value="F:biotin--[biotin carboxyl-carrier protein] ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16442">
        <property type="entry name" value="BPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004408">
        <property type="entry name" value="Biotin_CoA_COase_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004143">
        <property type="entry name" value="BPL_LPL_catalytic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835">
        <property type="entry name" value="BIOTIN PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12835:SF5">
        <property type="entry name" value="BIOTIN--PROTEIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03099">
        <property type="entry name" value="BPL_LplA_LipB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51733">
        <property type="entry name" value="BPL_LPL_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BPL/LPL catalytic" evidence="3">
        <location>
            <begin position="23"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="298" mass="33831" checksum="EEEC1C79EF329C75" modified="2005-04-12" version="1">MEDQKYKIYRHKELPLNICHFSTLPSTQIWAYENIDFLINTEKLSPNVWTVITADNMTSGIGSYDHKTRTPRTWYTLDGKNLNATYLTLRRREISEEPEKNISDLSLYTLGIALSVCKILGEFGIKEPKIKWVNDIYVNGKKIGGILSKQLEKRYVFEQVEYEPIVFGIGLNVLHDKCNLPENVESPATSVKIESELDSSLIGINDILESLHLEVIKSVTNINSSRHKGFQDNTLAEVNKRLLYKGKVVKIIDYEKEGNEIEMGVLQGVDKNGFAIIKLPEISGGELKISHGRIKFDG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTJ1</accession>
    <name>Q5CTJ1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">dCMP deaminase</fullName>
            <ecNumber evidence="7">3.5.4.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">dCMP deaminase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd2_2780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.4.12" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626478.1">
        <property type="nucleotide sequence ID" value="XM_626478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTJ1"/>
    <dbReference type="STRING" id="353152.Q5CTJ1"/>
    <dbReference type="GeneID" id="3373470"/>
    <dbReference type="KEGG" id="cpv:cgd2_2780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2780"/>
    <dbReference type="InParanoid" id="Q5CTJ1"/>
    <dbReference type="OMA" id="CEDSILY"/>
    <dbReference type="OrthoDB" id="6710946at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004132">
        <property type="term" value="F:dCMP deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009165">
        <property type="term" value="P:nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01286">
        <property type="entry name" value="deoxycytidylate_deaminase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016192">
        <property type="entry name" value="APOBEC/CMP_deaminase_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015517">
        <property type="entry name" value="dCMP_deaminase-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035105">
        <property type="entry name" value="Deoxycytidylate_deaminase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086:SF18">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11086">
        <property type="entry name" value="DEOXYCYTIDYLATE DEAMINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00903">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="9">
        <location>
            <begin position="223"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="373" mass="42360" checksum="67CB32BF316ED559" modified="2005-04-12" version="1">MIIVGLIGFDNVVAEYAFRFIVERFSFKGIRLVDCERNCNFDNAANKLKSTNKLESHFKTFGEECGKKAIRQICFCGSDSEESYDDCIRFRAKKAFMISTTDLNSSYVISKITKENEFDIFSNTFFVSLAIDLPLISKLSLLETNYENANFEEVEKSIEVLKNSPGKLKELASILVQDFEEKKRGICRLVRRSDYYISYFTDFSDLEKKLINLGLSKIDSRPNWDEYFMKIAKLASQRSNCVSRKVGSVIVKDKKIISTGYNGTPKNMKNCFEGGCTRCSNPNRVEGKSLETCSCMHAETNALLFAGIDKCIGATIYVTLMPCISCTKNIIQCEIERVVFTTEYAIPDEISTIKLLRDSNVKVDRLVEKQSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTL7</accession>
    <name>Q5CTL7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA polymerase II subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_2500</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase epsilon subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626452.1">
        <property type="nucleotide sequence ID" value="XM_626452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTL7"/>
    <dbReference type="FunCoup" id="Q5CTL7">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTL7"/>
    <dbReference type="GeneID" id="3373670"/>
    <dbReference type="KEGG" id="cpv:cgd2_2500"/>
    <dbReference type="InParanoid" id="Q5CTL7"/>
    <dbReference type="OMA" id="FFCEGCF"/>
    <dbReference type="OrthoDB" id="10254730at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016266">
        <property type="entry name" value="POLE2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12708">
        <property type="entry name" value="DNA POLYMERASE EPSILON SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="7">
        <location>
            <begin position="232"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="530" mass="61239" checksum="4F64A6B1D31FD17D" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTU5</accession>
    <name>Q5CTU5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd2_1520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626374.1">
        <property type="nucleotide sequence ID" value="XM_626374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTU5"/>
    <dbReference type="FunCoup" id="Q5CTU5">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTU5"/>
    <dbReference type="GeneID" id="3373720"/>
    <dbReference type="KEGG" id="cpv:cgd2_1520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1520"/>
    <dbReference type="InParanoid" id="Q5CTU5"/>
    <dbReference type="OMA" id="VEGSMEM"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="530"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="564"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="417"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="479"/>
            <end position="524"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="592" mass="67674" checksum="F73D7BB0DB3F49B4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU26</accession>
    <name>Q5CU26_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Large low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88885.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626293.1">
        <property type="nucleotide sequence ID" value="XM_626293.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU26"/>
    <dbReference type="GeneID" id="3373389"/>
    <dbReference type="KEGG" id="cpv:cgd2_560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_560"/>
    <dbReference type="InParanoid" id="Q5CU26"/>
    <dbReference type="OMA" id="ENINCEQ"/>
    <dbReference type="OrthoDB" id="294853at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88885.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2338" mass="271648" checksum="F49FE0EBA955F434" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU29</accession>
    <name>Q5CU29_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626290.1">
        <property type="nucleotide sequence ID" value="XM_626290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU29"/>
    <dbReference type="FunCoup" id="Q5CU29">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU29"/>
    <dbReference type="MEROPS" id="T01.997"/>
    <dbReference type="GeneID" id="3373658"/>
    <dbReference type="KEGG" id="cpv:cgd2_530"/>
    <dbReference type="InParanoid" id="Q5CU29"/>
    <dbReference type="OMA" id="CSEQLYG"/>
    <dbReference type="OrthoDB" id="204949at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03759">
        <property type="entry name" value="proteasome_beta_type_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033811">
        <property type="entry name" value="Proteasome_beta_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF10">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="204" mass="22632" checksum="1972B69536C9E578" modified="2005-04-12" version="1" fragment="single">SIMTYNGGAILAMKGKECVAFATDMRLGSNGYRTISTDFDKVIRPSSKTLMGFSGLATDIHTLTNLIKFKTNLYHLREEREIGVKALSHMTASILYSKRFSPYFVEPIVAGLDNNNVPFIAGYDLIGCLSVCSEFAISGTADNQLFGICESYYRPDLEPDELMEIVSQCMLSGIDRDAFSGWGCKVYLLTPEKLVTKTLKSRMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUA0</accession>
    <name>Q5CUA0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Centrin like EF hand protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_3650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88979.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626914.1">
        <property type="nucleotide sequence ID" value="XM_626914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUA0"/>
    <dbReference type="STRING" id="353152.Q5CUA0"/>
    <dbReference type="GeneID" id="3373858"/>
    <dbReference type="KEGG" id="cpv:cgd3_3650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3650"/>
    <dbReference type="InParanoid" id="Q5CUA0"/>
    <dbReference type="OMA" id="HECSAFI"/>
    <dbReference type="OrthoDB" id="340432at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008491">
        <property type="entry name" value="CDK5RAP3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05600">
        <property type="entry name" value="CDK5RAP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="410"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88979.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="471" mass="55664" checksum="930A7068C5B583FF" modified="2005-04-12" version="1">MEIQFSFLNEFLLGKKLVPRNWGILLKDIEKDLNELVKSNIGSNDQLSEEVKIYLNNIKDDEKNYKFLNKLIEFLISSKEGEMKTIFGNYKSKLINELLNIKKRYQDKNLYLSEAAKEANYILKFGLSHLEKEQREIVSKIKNTRKKVQELNTTKDKNIELINSELSSFGLENIITYSKVGLNTDYFPRDKISDGLQNFYDKKLKHFSSELFEEINELLKDDVLFNLYLELIKEANVDLVDSDKYIMEHLINFPTLKMLIGNLEKIGSESELSDNEKENKYSIELIDDSTIENSVSDENFKNFVILEESPLLIRLFEDRQLFGKLLMELYEIESFIKRSLVESFGMEWKAKINMNTDTKYKTIIEFYNLVKKIIGKLTESENYEIITFKRNKYVVIEKKVEVFFSIFNNIINQQNLINNLENRIKQYHQDLSESQQRYTESTQKLKENVILLQNELKNLLKKEYIIKGINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUA6</accession>
    <name>Q5CUA6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Developmentally-regulated GTP-binding protein 1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Translation factor GTPase DRG1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd3_3580</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626908.1">
        <property type="nucleotide sequence ID" value="XM_626908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUA6"/>
    <dbReference type="FunCoup" id="Q5CUA6">
        <property type="interactions" value="606"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUA6"/>
    <dbReference type="GeneID" id="3374108"/>
    <dbReference type="KEGG" id="cpv:cgd3_3580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3580"/>
    <dbReference type="InParanoid" id="Q5CUA6"/>
    <dbReference type="OMA" id="SAKHPGQ"/>
    <dbReference type="OrthoDB" id="603at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008092">
        <property type="term" value="F:cytoskeletal protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031116">
        <property type="term" value="P:positive regulation of microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01896">
        <property type="entry name" value="DRG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17230">
        <property type="entry name" value="TGS_DRG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000003">
        <property type="entry name" value="Developmentally-regulated GTP-binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002634">
        <property type="entry name" value="Small GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1070">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045001">
        <property type="entry name" value="DRG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031662">
        <property type="entry name" value="GTP-binding_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006074">
        <property type="entry name" value="GTP1-OBG_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43127">
        <property type="entry name" value="DEVELOPMENTALLY-REGULATED GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16897">
        <property type="entry name" value="MMR_HSR1_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00905">
        <property type="entry name" value="GTP1_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="12">
        <location>
            <begin position="66"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="13">
        <location>
            <begin position="291"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00072736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00080795"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK88986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="368" mass="40946" checksum="9EEBD7553FBB71C5" modified="2005-04-12" version="1">MSLLQKIAEIEAEMARTQKNKATNFHLGLLKAKLAKLRAQVISGGDGRGGGGGGNEGWDVSKTGEARVGLIGFPSVGKSTLLNKLTGTFSEVAAYEFTTLTCVPGVFNYKGAKIQLLDLPGIIEGAKDGKGRGRQVIGVGRTCSLILIVLDALKPLTHKRIIERELEGFGIRLNKQPPNISFTRKDRGGITITSTVQLKNIDEETIKSICSEYRINNANFVIRCDATADDIIDIIEGNRIYLPCIYILNKIDQITIEELDVLSQCPHYVPVSAHHEWNLDGLIEKIWQYLDLIRIYTKPKGQIPDYAAPVILKRDKSTIADFCRRIHKQLLPQMKYALVWGQSVRHNPQRVGKDHVLIDEDVVQIIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUK2</accession>
    <name>Q5CUK2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Myb domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_2510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626812.1">
        <property type="nucleotide sequence ID" value="XM_626812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUK2"/>
    <dbReference type="STRING" id="353152.Q5CUK2"/>
    <dbReference type="GeneID" id="3373779"/>
    <dbReference type="KEGG" id="cpv:cgd3_2510"/>
    <dbReference type="InParanoid" id="Q5CUK2"/>
    <dbReference type="OMA" id="SIYYCAK"/>
    <dbReference type="OrthoDB" id="39591at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47430">
        <property type="entry name" value="GB|AAC33480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47430:SF4">
        <property type="entry name" value="GB|AAC33480.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="3">
        <location>
            <begin position="102"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="2">
        <location>
            <begin position="102"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="406"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="441" mass="52007" checksum="51BFDF895C627C25" modified="2005-04-12" version="1" fragment="single">QKISVKTNMASNIFQTRSWNDHLNNRNILKGKFSSSERDIINNSVKDYIKSQQWNWDEGLDNLFSTRGGKKDRHWPIIGESLPNRSLQSIYYCAKRMLMRGKKGKWTKEEEQELIKLVNEHGKKWSMFVEFIGRSAASIRDKWRDLHTKIVENDSNDSGYILNLNSQIEKPLKSKMPFVIDVFVLYCIERYTGKFLPFKGISWKTIIESLCSPNFPTEFIYFWKKCCRKINEKLGINLQPIDGTDLSNFYGKISQGQIRLRYVSSLYPKLKYIQDEQALSLISNTFSQAVNYLYETRYNYSHIDEIKYNDWPKLLSAHIPLTTLWSRIRLALTRITKKNMHISDRISILYERLKNKLLKCQVLDSIDSTESRFLFEDDEDYANENMDGCPYFHVDTKRLRKTVVELLKTQSKREKKSKNAARLQKEYSSLQQVFQSGNYIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUS1</accession>
    <name>Q5CUS1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626743.1">
        <property type="nucleotide sequence ID" value="XM_626743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUS1"/>
    <dbReference type="GeneID" id="3374013"/>
    <dbReference type="KEGG" id="cpv:cgd3_1710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1710"/>
    <dbReference type="InParanoid" id="Q5CUS1"/>
    <dbReference type="OrthoDB" id="342762at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253872" evidence="1">
        <location>
            <begin position="20"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="300" mass="34132" checksum="760F379B217E793D" modified="2005-04-12" version="1">MNIFSLIGIHFLLFFGISANNNRLSIKEFSLLSLKENSDVNLYRKDARINVQECSPESMNLLLGIDQILKFEVTAYFCYLKNLRSAFESCKRRCTISRNIGRCRGIENRLAAATEKYNELLEQQTKWGKLLSYCIKCRALTEYMLIQSRGGIAKKSRITSRNSGDDPAYTPKNLLDSYLTRDFSSFELLYLSRMDTYLQTQKKLCGTKSRALCTCAKKTLKELKDNKSVLQSTVIKQDSFQRRWFTFNGGNIPSSGEPIDSIREECKHVLEKDAEIQNGIDGKLNAGFTGEELAPVTSVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUX2</accession>
    <name>Q5CUX2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626692.1">
        <property type="nucleotide sequence ID" value="XM_626692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUX2"/>
    <dbReference type="GeneID" id="3374168"/>
    <dbReference type="KEGG" id="cpv:cgd3_1140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1140"/>
    <dbReference type="InParanoid" id="Q5CUX2"/>
    <dbReference type="OrthoDB" id="344163at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253877" evidence="2">
        <location>
            <begin position="21"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="113"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="306" mass="36661" checksum="7B604012ED4AEE07" modified="2005-04-12" version="1">MFTYSLVFVILSVIILPCDIIPYKYGSFNLFLNNWLSISENNRFNIFSFSQLKKSQGLTRFSGFEMLSQLEDMNPEEMFEKIESRDESWLLQLTTNELELLLDKLKFLLDLQLNRHNELLSTLQIELSESQETVNELKVSEEFINKLLKCILVLLTQIVEKKLFKFEISLKQLKDSNRFTELELIQRELLFLQEIKDFIRNLFFVYYCKNPLVMNSSLCSFLTSVYSDTEAKFLSKTENLYEAYDKYENEWEDINDESIKLMNKRKKKKSNLKKKKFKSKAKRINFKKTKLKSRKKVKYQRKFNLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV88</accession>
    <name>Q5CV88_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RagC like small GTpase of the Ras superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_4990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627381.1">
        <property type="nucleotide sequence ID" value="XM_627381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV88"/>
    <dbReference type="STRING" id="353152.Q5CV88"/>
    <dbReference type="GeneID" id="3374203"/>
    <dbReference type="KEGG" id="cpv:cgd8_4990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4990"/>
    <dbReference type="InParanoid" id="Q5CV88"/>
    <dbReference type="OMA" id="NCRTFQE"/>
    <dbReference type="OrthoDB" id="26136at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF2">
        <property type="entry name" value="GH16429P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="378" mass="42169" checksum="63B9D6A96493FAF1" modified="2005-04-12" version="1">MISDTLRNNDLNLNVESDKTALTTGNSNHLLLGSQLLEKNNSNLVESSIYKIFPEEADRKIILENDIPLIMLCGLGSSGKTSIIKVLYDKVSPHETVSLYPTQSGSITLIKNESKILPCFGIIDLPGTGQIQDSLLGEDIFSKVSSLVFVIDSQNYPYNTEILRAKRLFQNAIQVKPGITFEVFLHKTDNETFSLDGAHLESQRDIHEKISSFIFQHGFEIDIRYHFTSIYNDSLLEAFSKVTQKISPFTQILEKLLDVLVISSSLEKAFLMDIYSRTFVASDSSLFDPIGFELCADILNVISEINEIYAPNCSLSRSSSGISCSINLDSGHLLHIQSIDHNIVLACVIRNEHVKNTSLININIDILKQTLIQKVLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVB6</accession>
    <name>Q5CVB6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome production factor 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Ribosome biogenesis protein RPF2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_4680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
            <location evidence="1 4">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the RPF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627353.1">
        <property type="nucleotide sequence ID" value="XM_627353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVB6"/>
    <dbReference type="STRING" id="353152.Q5CVB6"/>
    <dbReference type="GeneID" id="3374452"/>
    <dbReference type="KEGG" id="cpv:cgd8_4680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4680"/>
    <dbReference type="InParanoid" id="Q5CVB6"/>
    <dbReference type="OMA" id="VGLKPMF"/>
    <dbReference type="OrthoDB" id="407658at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039770">
        <property type="entry name" value="Rpf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728">
        <property type="entry name" value="BRIX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12728:SF0">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="29"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="332" mass="37670" checksum="B796970FE5930EE6" modified="2005-04-12" version="1">MAKSSSGKIKGSKKSVVIKRESQVNEETKRRLIIKGSKCKENIQNLLKDLYKIFPKAYTKIVRGITKGEAITSPWVDPHKMEQLSYKHGSSISIFANSSKKHPFRLIFTRYYDSHILDMYEFNVLNYKGISPNMELPKYGSKPIVICQGAPFESDDVYKSIRTMFFDTFSGPIVRGSKLFLKGFDHLILVTAYETDNEEINKQSTIIGSMNSKIYIDIRSYLIRLNRPSEQVPSELLIRSDQNLVLNGSPRVVLSEIGLQIKMELVKHQIPDKSILKSAMIVPREIKPKKIKNVTTNVLGESIGRIHVGKQDLSTLNTPHAGILSKINRSKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVN1</accession>
    <name>Q5CVN1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_3450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627238.1">
        <property type="nucleotide sequence ID" value="XM_627238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVN1"/>
    <dbReference type="FunCoup" id="Q5CVN1">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVN1"/>
    <dbReference type="GeneID" id="3374303"/>
    <dbReference type="KEGG" id="cpv:cgd8_3450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3450"/>
    <dbReference type="InParanoid" id="Q5CVN1"/>
    <dbReference type="OMA" id="NTYETAR"/>
    <dbReference type="OrthoDB" id="10254664at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00336">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.10">
        <property type="entry name" value="Ribosomal protein L22/L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001063">
        <property type="entry name" value="Ribosomal_uL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005721">
        <property type="entry name" value="Ribosomal_uL22_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036394">
        <property type="entry name" value="Ribosomal_uL22_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01038">
        <property type="entry name" value="uL22_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11593:SF10">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00237">
        <property type="entry name" value="Ribosomal_L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54843">
        <property type="entry name" value="Ribosomal protein L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="187" mass="21413" checksum="007989CBB11E9B31" modified="2005-04-12" version="1">MVRYAVRPDTPSKSVMCKGSDLRVSYKNTYETATAIKGMYLLDARQYLLDVIAKKRCVPFRRFNGGVGRTAKANEFKLTQGRFPEKSCRFLLDLLQNAESNCDMKGLDVDRLMLVSAVVTHAPFNRRRTFRAHGRITPFKSQPCNIQLIFKEIDDTVEQPKNIEGQKVVKLTKKQLARRKLRVGSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVR4</accession>
    <name>Q5CVR4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Swr1p like SWI/SNF2 family ATpase with a HSA domain at the N-terminus probably involved in chromatin remodelling</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd8_3080</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627205.1">
        <property type="nucleotide sequence ID" value="XM_627205.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CVR4">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVR4"/>
    <dbReference type="GeneID" id="3374319"/>
    <dbReference type="KEGG" id="cpv:cgd8_3080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3080"/>
    <dbReference type="InParanoid" id="Q5CVR4"/>
    <dbReference type="OMA" id="ELYDNNH"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18003">
        <property type="entry name" value="DEXQc_SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000005">
        <property type="entry name" value="Photoperiod-independent early flowering 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050520">
        <property type="entry name" value="INO80/SWR1_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685:SF1">
        <property type="entry name" value="HELICASE SRCAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45685">
        <property type="entry name" value="HELICASE SRCAP-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="13">
        <location>
            <begin position="13"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="350"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="1043"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK89483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1371" mass="160511" checksum="B2CE7FE818024DF8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVS0</accession>
    <name>Q5CVS0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Smc ABC ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd8_3010</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627199.1">
        <property type="nucleotide sequence ID" value="XM_627199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVS0"/>
    <dbReference type="STRING" id="353152.Q5CVS0"/>
    <dbReference type="GeneID" id="3374314"/>
    <dbReference type="KEGG" id="cpv:cgd8_3010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3010"/>
    <dbReference type="InParanoid" id="Q5CVS0"/>
    <dbReference type="OMA" id="MCHDHFY"/>
    <dbReference type="OrthoDB" id="10072614at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030915">
        <property type="term" value="C:Smc5-Smc6 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038729">
        <property type="entry name" value="Rad50/SbcC_AAA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES 5,6 SMC5, SMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19306:SF6">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13476">
        <property type="entry name" value="AAA_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad50/SbcC-type AAA" evidence="13">
        <location>
            <begin position="29"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="209"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="288"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="344"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="765"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="902"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="1052"/>
            <end position="1093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF13476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK89478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1268" mass="148560" checksum="6049C63389331015" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVT4</accession>
    <name>Q5CVT4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_2850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627185.1">
        <property type="nucleotide sequence ID" value="XM_627185.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVT4"/>
    <dbReference type="GeneID" id="3374346"/>
    <dbReference type="KEGG" id="cpv:cgd8_2850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2850"/>
    <dbReference type="InParanoid" id="Q5CVT4"/>
    <dbReference type="OMA" id="MSIALEW"/>
    <dbReference type="OrthoDB" id="339056at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="628" mass="73398" checksum="D27EB60BEB9E30EC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVW4</accession>
    <name>Q5CVW4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Apicomplexan specific membrane protein, 4+ transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_2550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627155.1">
        <property type="nucleotide sequence ID" value="XM_627155.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3374574"/>
    <dbReference type="KEGG" id="cpv:cgd8_2550"/>
    <dbReference type="InParanoid" id="Q5CVW4"/>
    <dbReference type="OMA" id="IHEDINH"/>
    <dbReference type="OrthoDB" id="340611at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="594"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="617"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="938"/>
            <end position="964"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1091"/>
            <end position="1110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1221"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="828"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1224"/>
            <end position="1263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1317" mass="151450" checksum="F60580979CE16C6F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVX8</accession>
    <name>Q5CVX8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627141.1">
        <property type="nucleotide sequence ID" value="XM_627141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVX8"/>
    <dbReference type="GeneID" id="3374462"/>
    <dbReference type="KEGG" id="cpv:cgd8_2400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2400"/>
    <dbReference type="InParanoid" id="Q5CVX8"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="47"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="249" mass="29352" checksum="4935E3EAB01E9D3D" modified="2005-04-12" version="1">MFNIFICCTHGNLNNSSTEDKEELIFELDKEKDSQGKSLSETFQNSIRELKKAETEALKIVEKAKKNKKDYLLQAEAAAEEIVKPYYELANQEYKEIEDSLNKEFHIKSLENILEIQESSDNIEEIDLKERKKQTIEYIYSKISDVKLILENPKYVKSQLEKHKVSKVHQKRHLIRSRFLSWRSKDYTEKEKESQKKHKQTNKEKTISFSVEKKDSSMSTIELDEDYSRIDNLYGASRVVNSFNTIHLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWD6</accession>
    <name>Q5CWD6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible apicomplexan protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626983.1">
        <property type="nucleotide sequence ID" value="XM_626983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWD6"/>
    <dbReference type="GeneID" id="3374428"/>
    <dbReference type="KEGG" id="cpv:cgd8_730"/>
    <dbReference type="InParanoid" id="Q5CWD6"/>
    <dbReference type="OMA" id="YSYICDP"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005892">
        <property type="term" value="C:acetylcholine-gated channel complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.310.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033438">
        <property type="entry name" value="MOLO1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748:SF5">
        <property type="entry name" value="GROUND-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33748">
        <property type="entry name" value="PROTEIN CBG04600"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17175">
        <property type="entry name" value="MOLO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="184" mass="19898" checksum="54B23C5C2D858838" modified="2005-04-12" version="1" fragment="single">NFSGRKGKVSSHICDPSKILSTEEGDYIDALLEDIKSTAVLKCGENMAGYNIGVAILPSNLGDGGEIANQLLESWNLRDVDCNNDIIFVYLASENRAIIRWGISVEPAINIVMYPELISEIDSVFLDKPIGPAIYNGISTIRRQLKENIGPPRRLPQLLVLSIIGGLTVLGFGALVVSAISDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWH7</accession>
    <name>Q5CWH7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_5030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627827.1">
        <property type="nucleotide sequence ID" value="XM_627827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWH7"/>
    <dbReference type="GeneID" id="3375824"/>
    <dbReference type="KEGG" id="cpv:cgd6_5030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5030"/>
    <dbReference type="InParanoid" id="Q5CWH7"/>
    <dbReference type="OMA" id="YMWTDEG"/>
    <dbReference type="OrthoDB" id="164025at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052289">
        <property type="entry name" value="Calcyclin-binding_UBL-bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164">
        <property type="entry name" value="CALICYLIN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164:SF6">
        <property type="entry name" value="CS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="1">
        <location>
            <begin position="70"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="175" mass="19640" checksum="B924DEF268159FB0" modified="2007-04-03" version="1">MGSSDKELSALRSNIKEKGEFSYYYAHKNNSQDLKDAKIFEGPGIVTGGQPILLHKDDEKEPVSDKPRSVQIKKYSWSDCGESIEIYISLQDLAELISSKSPLEIAGKPNLEVTNNTISLEVLSENTNFLFKIANLSNPIDSQLSRVKVSAKRITIICFKEDSELKWNSLCRPML</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWJ7</accession>
    <name>Q5CWJ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_4800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627807.1">
        <property type="nucleotide sequence ID" value="XM_627807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWJ7"/>
    <dbReference type="GeneID" id="3375808"/>
    <dbReference type="KEGG" id="cpv:cgd6_4800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4800"/>
    <dbReference type="InParanoid" id="Q5CWJ7"/>
    <dbReference type="OMA" id="HWIVANT"/>
    <dbReference type="OrthoDB" id="336321at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="439" mass="50314" checksum="4BEFB93F74C4B6FD" modified="2005-04-12" version="1">MPDDFSKSKENNDLFDILELDEETKNELVKNDIKTIPQLLLDNLRKKGLKSFQEARIYSKCREKITCFPNNVTEDQKINLCGIGIETGFVTGKKLLEEARENWSQNGDLRSHINLGSDILMDFFDGGFLAGETTELFGHDLPVIRRVVHWIISNTMFNSTLESLNVETELEGISPYQVIYIQTTDNSFDPIFMKKCFQRLCGELEMTQNSQYSTEISHNLELLLSNICVVTVDDCAQLQKLLYDLPRIKQKELKRLKLVVIDPITSLLGSHNFIEAQELSNNYYKEVKEKVFIVGRLIRYVSKALNISSVVTSLAKQSIKQTNTVLGYCSNQLLCDVNYPKSVHCEGFGTFYMPPPTRAFSTEIDYNWFLSPHNRILIENIGKVHEEYAGNPNACNNLAPHNLRILRWTIFKSNRLPIGKYVCAIFDKIGLVESECQFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWP1</accession>
    <name>Q5CWP1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative low complexity</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_4310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627763.1">
        <property type="nucleotide sequence ID" value="XM_627763.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWP1"/>
    <dbReference type="GeneID" id="3375775"/>
    <dbReference type="KEGG" id="cpv:cgd6_4310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4310"/>
    <dbReference type="InParanoid" id="Q5CWP1"/>
    <dbReference type="OMA" id="WIENTEI"/>
    <dbReference type="OrthoDB" id="437922at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024420">
        <property type="entry name" value="TRAPP_III_complex_Trs85"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975:SF6">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12975">
        <property type="entry name" value="TRANSPORT PROTEIN TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12739">
        <property type="entry name" value="TRAPPC-Trs85"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1931" mass="221364" checksum="56EB9918F00B8871" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWP6</accession>
    <name>Q5CWP6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627758.1">
        <property type="nucleotide sequence ID" value="XM_627758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWP6"/>
    <dbReference type="STRING" id="353152.Q5CWP6"/>
    <dbReference type="GeneID" id="3375771"/>
    <dbReference type="KEGG" id="cpv:cgd6_4260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4260"/>
    <dbReference type="InParanoid" id="Q5CWP6"/>
    <dbReference type="OMA" id="DTQLWEI"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="1">
        <location>
            <begin position="87"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="243" mass="28705" checksum="DBCDAF63EED8004A" modified="2007-04-03" version="1">MSGIDYSKWDKIEISSDEESEKFGSRCNVTRFDSPHSITIGGQIESEEDNKVKSNVTVDELKKIEPGHVSREKISSLNDYVFGGKSKNGKSYYWTQTENDLTIVIEISPEMQSKDFKINVTENSITIMYGLETILFEKFEYEVKYDDNTIFWSIKDVESFDKVQNKRIINKMLVLELEKKELNTSIRLWWKRIFKGSIETDISKFNRFTSSNKEERNKKFLQAWEKAHDEFRNKIQNRQKFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWQ9</accession>
    <name>Q5CWQ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_4110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627745.1">
        <property type="nucleotide sequence ID" value="XM_627745.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWQ9"/>
    <dbReference type="GeneID" id="3375759"/>
    <dbReference type="KEGG" id="cpv:cgd6_4110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4110"/>
    <dbReference type="InParanoid" id="Q5CWQ9"/>
    <dbReference type="OMA" id="VEMEWNT"/>
    <dbReference type="OrthoDB" id="343835at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044389">
        <property type="term" value="F:ubiquitin-like protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050899">
        <property type="entry name" value="DDRGK_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48176:SF1">
        <property type="entry name" value="DDRGK DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="496"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1019"/>
            <end position="1050"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1064"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1378"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1475"/>
            <end position="1503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1535"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="190"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="432"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1483"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1544"/>
            <end position="1567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1577"/>
            <end position="1595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1698" mass="180540" checksum="FD8821BEEAD31481" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWS7</accession>
    <name>Q5CWS7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627727.1">
        <property type="nucleotide sequence ID" value="XM_627727.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWS7"/>
    <dbReference type="GeneID" id="3375744"/>
    <dbReference type="KEGG" id="cpv:cgd6_3900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3900"/>
    <dbReference type="InParanoid" id="Q5CWS7"/>
    <dbReference type="OMA" id="CCKNNDE"/>
    <dbReference type="OrthoDB" id="343207at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="344" mass="38552" checksum="1427409EE5A60E6C" modified="2007-04-03" version="1">MRRSESSSVLQRYNNRRKSSISGGRTASASMIGILTPKTLSSMKDSSKKEKSTWSRIFSPLSFGFDKRELSYSGEESSYSQSRRRTHDYSKTCPSFQRKGSLRPSPNTQVRDRNQSISKEPRSSLQYSASATDLSFDNDILGLNDLSSCVFEPVLGNMSKSNNISRVQPFSGKDTAGYIQRSRTTGFIKEDKSTNIYNDLKILRFHDGISGKTYKALPSKTLDSIKDSDKVGKEKTATTATGFNLGFGSSTKNTNSNAGNSSGTNFIEIDPNNKTHLFNKDNFTANRNTSIKEALSNKEFIQGDIPYCDTILYLDNPKPKKYDTTFSKLHDNSFYKDSFNSRFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWV5</accession>
    <name>Q5CWV5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Myotubularin related protein 1, C-terminus protein tyrosine/serine phosphatase, catalytic domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_3570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627699.1">
        <property type="nucleotide sequence ID" value="XM_627699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWV5"/>
    <dbReference type="STRING" id="353152.Q5CWV5"/>
    <dbReference type="GeneID" id="3375720"/>
    <dbReference type="KEGG" id="cpv:cgd6_3570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3570"/>
    <dbReference type="InParanoid" id="Q5CWV5"/>
    <dbReference type="OMA" id="WNINRAS"/>
    <dbReference type="OrthoDB" id="271628at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004438">
        <property type="term" value="F:phosphatidylinositol-3-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14507">
        <property type="entry name" value="PTP-MTM-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030564">
        <property type="entry name" value="Myotubularin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010569">
        <property type="entry name" value="Myotubularin-like_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807">
        <property type="entry name" value="MYOTUBULARIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10807:SF128">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3,5-BISPHOSPHATE 3-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06602">
        <property type="entry name" value="Myotub-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51339">
        <property type="entry name" value="PPASE_MYOTUBULARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myotubularin phosphatase" evidence="4">
        <location>
            <begin position="421"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="110"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="112"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphocysteine intermediate" evidence="1">
        <location>
            <position position="692"/>
        </location>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="586"/>
            <end position="587"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="2">
        <location>
            <begin position="692"/>
            <end position="698"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR630564-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="910" mass="101996" checksum="022E59BA77716DAA" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX31</accession>
    <name>Q5CX31_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627623.1">
        <property type="nucleotide sequence ID" value="XM_627623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX31"/>
    <dbReference type="GeneID" id="3376149"/>
    <dbReference type="KEGG" id="cpv:cgd6_2710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2710"/>
    <dbReference type="InParanoid" id="Q5CX31"/>
    <dbReference type="OMA" id="TIGRAEY"/>
    <dbReference type="OrthoDB" id="342207at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="322"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="358"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="516" mass="57960" checksum="30A72EBEB59DE687" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX54</accession>
    <name>Q5CX54_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,4 glucan phosphorylase</fullName>
            <ecNumber evidence="10">2.4.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_2450</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[(1-&gt;4)-alpha-D-glucosyl](n) + phosphate = [(1-&gt;4)-alpha-D-glucosyl](n-1) + alpha-D-glucose 1-phosphate</text>
            <dbReference type="Rhea" id="RHEA:41732"/>
            <dbReference type="Rhea" id="RHEA-COMP:9584"/>
            <dbReference type="Rhea" id="RHEA-COMP:9586"/>
            <dbReference type="ChEBI" id="CHEBI:15444"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="2.4.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 10">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the glycogen phosphorylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.1" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627600.1">
        <property type="nucleotide sequence ID" value="XM_627600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX54"/>
    <dbReference type="SMR" id="Q5CX54"/>
    <dbReference type="STRING" id="353152.Q5CX54"/>
    <dbReference type="GeneID" id="3376131"/>
    <dbReference type="KEGG" id="cpv:cgd6_2450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2450"/>
    <dbReference type="InParanoid" id="Q5CX54"/>
    <dbReference type="OMA" id="HCACSVA"/>
    <dbReference type="OrthoDB" id="9215500at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008184">
        <property type="term" value="F:glycogen phosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04300">
        <property type="entry name" value="GT35_Glycogen_Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000002">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000003">
        <property type="entry name" value="Alpha-1,4 glucan phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011833">
        <property type="entry name" value="Glycg_phsphrylas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000811">
        <property type="entry name" value="Glyco_trans_35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035090">
        <property type="entry name" value="Pyridoxal_P_attach_site"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02093">
        <property type="entry name" value="P_ylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11468:SF3">
        <property type="entry name" value="GLYCOGEN PHOSPHORYLASE, LIVER FORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00343">
        <property type="entry name" value="Phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000460">
        <property type="entry name" value="Pprylas_GlgP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00102">
        <property type="entry name" value="PHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="8 10" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="5 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9 10" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0808">Transferase</keyword>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="9">
        <location>
            <position position="724"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000460-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="901" mass="104212" checksum="7888D6C537F72E80" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX69</accession>
    <name>Q5CX69_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_2280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGX family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627585.1">
        <property type="nucleotide sequence ID" value="XM_627585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX69"/>
    <dbReference type="GeneID" id="3376177"/>
    <dbReference type="KEGG" id="cpv:cgd6_2280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2280"/>
    <dbReference type="InParanoid" id="Q5CX69"/>
    <dbReference type="OMA" id="INECSGI"/>
    <dbReference type="OrthoDB" id="340581at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013233">
        <property type="entry name" value="PIG-X/PBN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040039">
        <property type="entry name" value="PIGX"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28650:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS X PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08320">
        <property type="entry name" value="PIG-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="406"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="429" mass="49226" checksum="18440E702A3A9DE6" modified="2007-04-03" version="1">MKKINFFQYYIGLFVFFIALFSELDAYSGSFTKLEDFGSKGYRVTTETFNVTANAFYTNVEKEINECVDWYSVIFTSRSFGQLIIPSLPNGLFIFFSKKRAIKCNKDEKIKEYFLSIPNINLGFDISVINNFTKLYSKEEITYELNKVNKQFYLDILSKSNPFTPNHPEFFSLEGEELTYIHFPHLEVESKILKKLLQGMFELDLINSQTLSLLRFSNKNHSNKWTTKITSFTINKNNTGKNCESGNLEVVRKLSGSGFHWNLETELINFENTPILLDSFNREIFVDIDEISQRNEKKVDGILVPLHPVHIERPSEESDSSMLLSIGKSSDIPIHARYQSACNGCNFKTVKIGFPSIVIYEKESVDKHCLIPKLRFEIATNQNVKTGSSQEIVINIPVGNSKDINYVFIATIFTIIITTVTTGISIKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX92</accession>
    <name>Q5CX92_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">YbiN-like RNA methylase (NPPY variety HemK family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_2010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627562.1">
        <property type="nucleotide sequence ID" value="XM_627562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX92"/>
    <dbReference type="STRING" id="353152.Q5CX92"/>
    <dbReference type="GeneID" id="3376074"/>
    <dbReference type="KEGG" id="cpv:cgd6_2010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2010"/>
    <dbReference type="InParanoid" id="Q5CX92"/>
    <dbReference type="OMA" id="HQGRYDF"/>
    <dbReference type="OrthoDB" id="514248at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008988">
        <property type="term" value="F:rRNA (adenine-N6-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010286">
        <property type="entry name" value="METTL16/RlmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016909">
        <property type="entry name" value="rRNA_lsu_MeTfrase_F"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393:SF0">
        <property type="entry name" value="RNA N6-ADENOSINE-METHYLTRANSFERASE METTL16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13393">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05971">
        <property type="entry name" value="Methyltransf_10"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF029038">
        <property type="entry name" value="Mtase_YbiN_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="348" mass="40597" checksum="4DF0CCFB1CC55E2C" modified="2007-04-03" version="1">MGQANNKNQQKKATQLHHRNVHANDDFLFLSERYPELKKCIKIINNKVRINYNPAALHCISKVLLHYRYNINWDIPDKFLIPTIPSRANYVHFISDLLTPEHFYNTEKVNDEGLRNDLKTKTCIEGGTDVCFSELIPRGKQVLGFDIGIGANCIFSLLCNKIYSWNMIGSDISIESLSVSDTIIKKNNLCGCIKLLHQEKPEYILFGILDKTEIEDLKFSFTICNPPYYDSVEDSEINMHPARFRSCQNYEIITHGGESQFILKLYFESKNFSKRVIWYTSQVSKLKNLKFLKSVLKKEIINNELKSLRYTTLKQGKHDKWVIAWSFFEKEERTSILKFLRNNKNMSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXH2</accession>
    <name>Q5CXH2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_1100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627482.1">
        <property type="nucleotide sequence ID" value="XM_627482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXH2"/>
    <dbReference type="STRING" id="353152.Q5CXH2"/>
    <dbReference type="GeneID" id="3376026"/>
    <dbReference type="KEGG" id="cpv:cgd6_1100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1100"/>
    <dbReference type="InParanoid" id="Q5CXH2"/>
    <dbReference type="OrthoDB" id="343790at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46563:SF4">
        <property type="entry name" value="ASPARTYL_ASPARAGINYL BETA-HYDROXYLASE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46563">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254515" evidence="2">
        <location>
            <begin position="22"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="283"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="534" mass="60641" checksum="E480D8A725208416" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXS2</accession>
    <name>Q5CXS2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oocyst wall protein 5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_5150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628658.1">
        <property type="nucleotide sequence ID" value="XM_628656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXS2"/>
    <dbReference type="GeneID" id="3372090"/>
    <dbReference type="KEGG" id="cpv:cgd7_5150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5150"/>
    <dbReference type="InParanoid" id="Q5CXS2"/>
    <dbReference type="OMA" id="FFDGRNC"/>
    <dbReference type="OrthoDB" id="7250310at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254618" evidence="2">
        <location>
            <begin position="24"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="604"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="629" mass="71106" checksum="32BDF23406CACCF1" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXU2</accession>
    <name>Q5CXU2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">glutamate-5-semialdehyde dehydrogenase</fullName>
            <ecNumber evidence="2">1.2.1.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_4940</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-glutamate 5-semialdehyde + phosphate + NADP(+) = L-glutamyl 5-phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19541"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58066"/>
            <dbReference type="ChEBI" id="CHEBI:58274"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.2.1.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.41" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628638.1">
        <property type="nucleotide sequence ID" value="XM_628636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXU2"/>
    <dbReference type="STRING" id="353152.Q5CXU2"/>
    <dbReference type="GeneID" id="3372230"/>
    <dbReference type="KEGG" id="cpv:cgd7_4940"/>
    <dbReference type="InParanoid" id="Q5CXU2"/>
    <dbReference type="OMA" id="KTQRYGT"/>
    <dbReference type="OrthoDB" id="1934954at2759"/>
    <dbReference type="UniPathway" id="UPA00098">
        <property type="reaction ID" value="UER00360"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004350">
        <property type="term" value="F:glutamate-5-semialdehyde dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd07079">
        <property type="entry name" value="ALDH_F18-19_ProA-GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00412">
        <property type="entry name" value="ProA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020593">
        <property type="entry name" value="G-glutamylP_reductase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012134">
        <property type="entry name" value="Glu-5-SA_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000965">
        <property type="entry name" value="GPR_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001221">
        <property type="entry name" value="PRK00197.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00407">
        <property type="entry name" value="proA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063:SF8">
        <property type="entry name" value="DELTA-1-PYRROLINE-5-CARBOXYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11063">
        <property type="entry name" value="GLUTAMATE SEMIALDEHYDE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000151">
        <property type="entry name" value="GPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01223">
        <property type="entry name" value="PROA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="8">
        <location>
            <begin position="11"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="443" mass="49866" checksum="49FFDEDC16A10FE7" modified="2005-04-12" version="1">MSEEILDIGEIARRSRESGIQLSSSTVEERNAILEHFAEEIYLNRNEILEANMKDMDNSNKNNISEPMKMRLLLDESKLKACISSVRDVMNLEDPLGKYTLSREITSNGLKLYRRTCPIGVILVIFEARPEVAIQISSLTIKSGNAVILKGGKEAINTNKAILNCIENAINQVKKNYININREIVQMVFSHEDVNKLLSFNQFIDLVIPRGSGELVHMIKKNTCIPVLGHADGVCMLYVHVDANISKGVEIVIDGKLDYPAACNSLETLLIHKDKLSEFLPALLLRLKEQGKHIKFYSDKECLKYLEGENDVCELIEDLYHHEFSSNEMCVKSVSSMDEAIAHINQYGSHHTDVILTQDEKLAASFMNRVDSACVFHNCSSRFSDGYRFGFGAEIGISTTRIHARGPVGLEGLLTYKYTLRGQGQTITQFKHGKFTFTKRDIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="131" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY06</accession>
    <name>Q5CY06_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">P-type Ca(2+) transporter</fullName>
            <ecNumber evidence="2">7.2.2.10</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">cgd7_4190</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="14">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.10" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628574.1">
        <property type="nucleotide sequence ID" value="XM_628572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY06"/>
    <dbReference type="FunCoup" id="Q5CY06">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY06"/>
    <dbReference type="GeneID" id="3372076"/>
    <dbReference type="KEGG" id="cpv:cgd7_4190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4190"/>
    <dbReference type="InParanoid" id="Q5CY06"/>
    <dbReference type="OMA" id="PLWNNMM"/>
    <dbReference type="OrthoDB" id="3352408at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005388">
        <property type="term" value="F:P-type calcium transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000027">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1110.10:FF:000037">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.150.10:FF:000014">
        <property type="entry name" value="Calcium-transporting ATPase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006068">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004014">
        <property type="entry name" value="ATPase_P-typ_cation-transptr_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42861">
        <property type="entry name" value="CALCIUM-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00689">
        <property type="entry name" value="Cation_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00690">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0109">Calcium transport</keyword>
    <keyword evidence="12" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="13 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 15 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="267"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="299"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="861"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="894"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="932"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1043"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1071"/>
            <end position="1095"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="7"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAK90400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1129" mass="123972" checksum="8986990E22DB800F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY09</accession>
    <name>Q5CY09_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PP2C phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628571.1">
        <property type="nucleotide sequence ID" value="XM_628569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY09"/>
    <dbReference type="STRING" id="353152.Q5CY09"/>
    <dbReference type="DNASU" id="3372073"/>
    <dbReference type="GeneID" id="3372073"/>
    <dbReference type="KEGG" id="cpv:cgd7_4150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4150"/>
    <dbReference type="InParanoid" id="Q5CY09"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="301"/>
            <end position="629"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="629" mass="69923" checksum="30DBE777A82E5CEA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY34</accession>
    <name>Q5CY34_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628546.1">
        <property type="nucleotide sequence ID" value="XM_628544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY34"/>
    <dbReference type="GeneID" id="3372132"/>
    <dbReference type="KEGG" id="cpv:cgd7_3840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3840"/>
    <dbReference type="InParanoid" id="Q5CY34"/>
    <dbReference type="OMA" id="VECTIAL"/>
    <dbReference type="OrthoDB" id="340412at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="750" mass="84045" checksum="B4E234F7A2A3637E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY58</accession>
    <name>Q5CY58_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mpp10 family of U3 processosome protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_3590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the MPP10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628522.1">
        <property type="nucleotide sequence ID" value="XM_628520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY58"/>
    <dbReference type="FunCoup" id="Q5CY58">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY58"/>
    <dbReference type="GeneID" id="3372109"/>
    <dbReference type="KEGG" id="cpv:cgd7_3590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3590"/>
    <dbReference type="InParanoid" id="Q5CY58"/>
    <dbReference type="OMA" id="NICFHIP"/>
    <dbReference type="OrthoDB" id="445326at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012173">
        <property type="entry name" value="Mpp10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17039:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN MPP10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04006">
        <property type="entry name" value="Mpp10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="484"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="484"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="551" mass="63919" checksum="06AF52003F5F0517" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY77</accession>
    <name>Q5CY77_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted alpha beta hydrolyse, signal peptide, secreted patatin like esterase (Ralstonia best hits)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_3390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628503.1">
        <property type="nucleotide sequence ID" value="XM_628501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY77"/>
    <dbReference type="GeneID" id="3372053"/>
    <dbReference type="KEGG" id="cpv:cgd7_3390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3390"/>
    <dbReference type="InParanoid" id="Q5CY77"/>
    <dbReference type="OMA" id="CIISINN"/>
    <dbReference type="OrthoDB" id="17120at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254539" evidence="3">
        <location>
            <begin position="19"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="46"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="83"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="228"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="85"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="794" mass="90391" checksum="40A704D8687BFFBE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY95</accession>
    <name>Q5CY95_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_3200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628485.1">
        <property type="nucleotide sequence ID" value="XM_628483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY95"/>
    <dbReference type="STRING" id="353152.Q5CY95"/>
    <dbReference type="GeneID" id="3371979"/>
    <dbReference type="KEGG" id="cpv:cgd7_3200"/>
    <dbReference type="InParanoid" id="Q5CY95"/>
    <dbReference type="OMA" id="QSTLGFC"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="30"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="201"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="251"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="159"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="331" mass="38388" checksum="F7E25CEACDC55556" modified="2005-04-12" version="1" fragment="single">ELYFTMDGFAKCMDSIINCFECFAKFLGHFLIAFVFFAISFLYTSGTFFIFPFMIKNSVILILTRLALFFFTVNLVYNYILCLITCPGFSKPISKREESRNEVSQYDIEAGELLFLESRNIFNDRNSQIEDSFLPEEYFKDHDKNNLFIDQGKNYMINCSKCNAIKHPRTHHCSICNKCILNMDHHCPWIGQCVGLYNRKYFILFLAWSFLSCFLISIFSIPMIIILLSSLSGINYYSDASLYDNVTFQGLLFSSVLSVSFSLGTGTLLFFHIYLLVTNQSTIEYHQNLFFRKSLNGGEALINRFDKGLSNNIREIMGTSRFPLLLFPCFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYE0</accession>
    <name>Q5CYE0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SMC3'SMC type chromosomal ABC ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd7_2700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628440.1">
        <property type="nucleotide sequence ID" value="XM_628438.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CYE0">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYE0"/>
    <dbReference type="GeneID" id="3371972"/>
    <dbReference type="KEGG" id="cpv:cgd7_2700"/>
    <dbReference type="InParanoid" id="Q5CYE0"/>
    <dbReference type="OMA" id="GQKTVCA"/>
    <dbReference type="OrthoDB" id="431497at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051276">
        <property type="term" value="P:chromosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03272">
        <property type="entry name" value="ABC_SMC3_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041741">
        <property type="entry name" value="SMC3_ABC_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="5 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0498">Mitosis</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="15"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="domain" description="SMC hinge" evidence="10">
        <location>
            <begin position="560"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="298"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK90624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1304" mass="151322" checksum="2DD9A1DDA92D72B5" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYF4</accession>
    <name>Q5CYF4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L35A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_2540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL33 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628426.1">
        <property type="nucleotide sequence ID" value="XM_628424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYF4"/>
    <dbReference type="FunCoup" id="Q5CYF4">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYF4"/>
    <dbReference type="GeneID" id="3371922"/>
    <dbReference type="KEGG" id="cpv:cgd7_2540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2540"/>
    <dbReference type="InParanoid" id="Q5CYF4"/>
    <dbReference type="OMA" id="YRTNKHH"/>
    <dbReference type="OrthoDB" id="504467at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.190:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.190">
        <property type="entry name" value="translation elongation factor selb, chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00573">
        <property type="entry name" value="Ribosomal_eL33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001780">
        <property type="entry name" value="Ribosomal_eL33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038661">
        <property type="entry name" value="Ribosomal_eL33_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10902">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01247">
        <property type="entry name" value="Ribosomal_L35Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="120" mass="13556" checksum="0DEFC9EA59414ECE" modified="2005-04-12" version="1">MKSQIKKKSFNNKTTEPVRLYSKAIVTGYKRSKVNQTPNVSLLKIEGVKTKEDAKFYLGKRCAYIYKAKTIKNGTKFRVIQGLIRRSYGNSGAVCAKFRKALPPSSFGGRVRVFLFPSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYF5</accession>
    <name>Q5CYF5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large membrane protein with signal peptide and transmembrane domain near carboxy terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628425.1">
        <property type="nucleotide sequence ID" value="XM_628423.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYF5"/>
    <dbReference type="GeneID" id="3371921"/>
    <dbReference type="KEGG" id="cpv:cgd7_2530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2530"/>
    <dbReference type="InParanoid" id="Q5CYF5"/>
    <dbReference type="OMA" id="INDREYY"/>
    <dbReference type="OrthoDB" id="361283at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045197">
        <property type="entry name" value="NUP210-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019:SF0">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN 210"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23019">
        <property type="entry name" value="NUCLEAR PORE MEMBRANE GLYCOPROTEIN GP210-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2347"/>
            <end position="2364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2387" mass="277690" checksum="F01E71A13731D554" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYP0</accession>
    <name>Q5CYP0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal protein of the PO/L10 family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_1600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628340.1">
        <property type="nucleotide sequence ID" value="XM_628338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYP0"/>
    <dbReference type="FunCoup" id="Q5CYP0">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYP0"/>
    <dbReference type="GeneID" id="3371731"/>
    <dbReference type="KEGG" id="cpv:cgd7_1600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1600"/>
    <dbReference type="InParanoid" id="Q5CYP0"/>
    <dbReference type="OMA" id="KYMWDVQ"/>
    <dbReference type="OrthoDB" id="10262308at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051742">
        <property type="entry name" value="Ribosome_Assembly_uL10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841:SF1">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45841">
        <property type="entry name" value="MRNA TURNOVER PROTEIN 4 MRTO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="222" mass="25415" checksum="7D966F245D5DA36E" modified="2005-04-12" version="1">MAKSKRVKKVLMTKDLKKKRKDKSEIIENVHEYIGKFKFIYVVKLKNQRNAALKQLRVRLEPGKLLVGKNKLLQVAFGADSDSESAKNAHKISSFLRGERGLIFTDLAPSNLNKVLEESSTMEFGREGSLSDITCVVEPNTELECLYKNAEFYMRKQFPQLKPTLLGSDQGKVIICEKGNPLNKYQYLLLKHLEIPSVKFEIKPIACLHNEELTHFENADME</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYP8</accession>
    <name>Q5CYP8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Tryptophan--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tryptophanyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd7_1490</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="journal article" date="2011" name="Mol. Biochem. Parasitol." volume="177" first="20" last="28">
            <title>Crystal structures of three protozoan homologs of tryptophanyl-tRNA synthetase.</title>
            <authorList>
                <person name="Merritt E.A."/>
                <person name="Arakaki T.L."/>
                <person name="Gillespie R."/>
                <person name="Napuli A.J."/>
                <person name="Kim J.E."/>
                <person name="Buckner F.S."/>
                <person name="Van Voorhis W.C."/>
                <person name="Verlinde C.L."/>
                <person name="Fan E."/>
                <person name="Zucker F."/>
                <person name="Hol W.G."/>
            </authorList>
            <dbReference type="PubMed" id="21255615"/>
            <dbReference type="DOI" id="10.1016/j.molbiopara.2011.01.003"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.42 ANGSTROMS) OF 206-593</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Trp) + L-tryptophan + ATP = L-tryptophyl-tRNA(Trp) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24080"/>
            <dbReference type="Rhea" id="RHEA-COMP:9671"/>
            <dbReference type="Rhea" id="RHEA-COMP:9705"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78535"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.2"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.2" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628332.1">
        <property type="nucleotide sequence ID" value="XM_628330.1"/>
    </dbReference>
    <dbReference type="PDB" id="3HV0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.42 A"/>
        <property type="chains" value="A/B=206-593"/>
    </dbReference>
    <dbReference type="PDBsum" id="3HV0"/>
    <dbReference type="AlphaFoldDB" id="Q5CYP8"/>
    <dbReference type="SMR" id="Q5CYP8"/>
    <dbReference type="FunCoup" id="Q5CYP8">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYP8"/>
    <dbReference type="GeneID" id="3372249"/>
    <dbReference type="KEGG" id="cpv:cgd7_1490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1490"/>
    <dbReference type="InParanoid" id="Q5CYP8"/>
    <dbReference type="OMA" id="SIYHRFM"/>
    <dbReference type="OrthoDB" id="10261385at2759"/>
    <dbReference type="BRENDA" id="6.1.1.2">
        <property type="organism ID" value="1728"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="Q5CYP8"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004830">
        <property type="term" value="F:tryptophan-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006436">
        <property type="term" value="P:tryptophanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00806">
        <property type="entry name" value="TrpRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.240.10:FF:000007">
        <property type="entry name" value="Tryptophan--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000033">
        <property type="entry name" value="tryptophan--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.240.10">
        <property type="entry name" value="Tyrosyl-Transfer RNA Synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002306">
        <property type="entry name" value="Trp-tRNA-ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00233">
        <property type="entry name" value="trpS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055:SF1">
        <property type="entry name" value="TRYPTOPHAN--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10055">
        <property type="entry name" value="TRYPTOPHANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01039">
        <property type="entry name" value="TRNASYNTHTRP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="16" id="KW-0002">3D-structure</keyword>
    <keyword evidence="10 13 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00030268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK90203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="3HV0"/>
        </source>
    </evidence>
    <sequence length="593" mass="67886" checksum="ECE9587B2ECF6ECC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYP9</accession>
    <name>Q5CYP9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_1480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628331.1">
        <property type="nucleotide sequence ID" value="XM_628329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYP9"/>
    <dbReference type="GeneID" id="3372248"/>
    <dbReference type="KEGG" id="cpv:cgd7_1480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1480"/>
    <dbReference type="InParanoid" id="Q5CYP9"/>
    <dbReference type="OMA" id="ENNCTIP"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="501" mass="56951" checksum="9ABCA2E551B9C404" modified="2005-04-12" version="1">MLKDFLQTFERYSLPEKSEYLEISILVDQDLDPKEYSKLSEAHFLQLLILAQNQLKLFLESRFIHEAVPENSKIIAVSSNLPLLITLSFLLEDKKKSLLVYDELEDCFIGSFTCFDALLIFYILYILVKNENSEEIDDNFPFKTLEELSKCSIKHWLKKVLDTNEALSKKLITMSETLYEGLKLCLDLESNYKRIKLKDQEFNYNDLGTWVIEDRNDLSESKSFKEELGSKSMGLYPICYFSPLTILSDLVQNLQICSGSIPKEKFQPEDEVATAAEKDDPDCDMTPQGSVFGRVFHNKVLKHLGMGKKVPKSLKASSPLRLALEMFLKEGLTHIPIVFEEDNTFTGTVLTMEKCCMYLARCVSNQEKALMEDSIENIFNIYNKEAYDTLGNTVIQLSGLNCGKGCFEYNNNSDISTSKIDTRKIGDEKEFKEENQVKDNTENDGCNSSFLVDICLSGAISHILLSEDQCLILVDKKTNQVTALLTALDICKLLTGAQTQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYT2</accession>
    <name>Q5CYT2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">3CCCH domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_1120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628298.1">
        <property type="nucleotide sequence ID" value="XM_628296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYT2"/>
    <dbReference type="STRING" id="353152.Q5CYT2"/>
    <dbReference type="GeneID" id="3371778"/>
    <dbReference type="KEGG" id="cpv:cgd7_1120"/>
    <dbReference type="InParanoid" id="Q5CYT2"/>
    <dbReference type="OMA" id="GSEESHN"/>
    <dbReference type="OrthoDB" id="430732at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25427">
        <property type="entry name" value="zf-CCCH_UNK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="92"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="127"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="162"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="245"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="320"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="325"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="591" mass="65441" checksum="C860464561802AD5" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYY7</accession>
    <name>Q5CYY7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628243.1">
        <property type="nucleotide sequence ID" value="XM_628241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYY7"/>
    <dbReference type="FunCoup" id="Q5CYY7">
        <property type="interactions" value="465"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYY7"/>
    <dbReference type="GeneID" id="3371912"/>
    <dbReference type="KEGG" id="cpv:cgd7_520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_520"/>
    <dbReference type="InParanoid" id="Q5CYY7"/>
    <dbReference type="OMA" id="GMVEYWR"/>
    <dbReference type="OrthoDB" id="271386at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01927">
        <property type="entry name" value="cyclophilin_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000003">
        <property type="entry name" value="Peptidylprolyl isomerase domain and WD repeat-containing 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044666">
        <property type="entry name" value="Cyclophilin_A-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45625:SF4">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE DOMAIN AND WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="139"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="337"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="621"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="76"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="26"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="778" mass="89006" checksum="B457B7D09B479CF0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPL4</accession>
    <name>A3FPL4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_20</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388360.1">
        <property type="nucleotide sequence ID" value="XM_001388323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPL4"/>
    <dbReference type="STRING" id="353152.A3FPL4"/>
    <dbReference type="GeneID" id="3371819"/>
    <dbReference type="KEGG" id="cpv:cgd7_20"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_20"/>
    <dbReference type="InParanoid" id="A3FPL4"/>
    <dbReference type="OMA" id="WAVAYNR"/>
    <dbReference type="OrthoDB" id="10264606at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF3">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR CACTUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="36"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="102"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="136"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="216" mass="24121" checksum="1347842315935A1A" modified="2007-04-03" version="1">MERNKFFAAIDFEDESLAKSIFESISEAQLNIFDEDERTLLHNAVSKNKLFIVELLISKGANVNTFDDNKWSPLHSCCSSGYFEIARLLLESGADCRAKTSSGCTPLHYAASKGHEDIVKLIIAKERSVIDIQDIYGRTAIFMSACSGKQECFDLLFQANADLNLKENATGDTILHAAINGFHEEIAYKIASKNPEMLMVKNKVSLQSYITQFTSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPR3</accession>
    <name>A3FPR3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388409.1">
        <property type="nucleotide sequence ID" value="XM_001388372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPR3"/>
    <dbReference type="STRING" id="353152.A3FPR3"/>
    <dbReference type="GeneID" id="3371811"/>
    <dbReference type="KEGG" id="cpv:cgd7_4550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4550"/>
    <dbReference type="InParanoid" id="A3FPR3"/>
    <dbReference type="OMA" id="YAGKQMA"/>
    <dbReference type="OrthoDB" id="1043111at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000226">
        <property type="entry name" value="Ubiquitin-like protein nedd8 homologue, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="1">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="78" mass="8934" checksum="AB21C9DBA69A1BE4" modified="2007-04-03" version="1">MQILVKTLTGKKQNFNFEPENTVLQVKQALQEKEGIDVKQIRLIYSGKQMSDDLRLLDYKVTAGCTIHMVLQLRGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPX4</accession>
    <name>A3FPX4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388353.1">
        <property type="nucleotide sequence ID" value="XM_001388316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPX4"/>
    <dbReference type="GeneID" id="3375978"/>
    <dbReference type="KEGG" id="cpv:cgd6_4870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4870"/>
    <dbReference type="InParanoid" id="A3FPX4"/>
    <dbReference type="OMA" id="TIKDIMH"/>
    <dbReference type="OrthoDB" id="342010at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="564" mass="64929" checksum="F4C5D1515AC78D00" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPZ4</accession>
    <name>A3FPZ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Phosphatidylinositol-4-phosphate 5-kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_3280</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388435.1">
        <property type="nucleotide sequence ID" value="XM_001388398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPZ4"/>
    <dbReference type="FunCoup" id="A3FPZ4">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPZ4"/>
    <dbReference type="GeneID" id="3374654"/>
    <dbReference type="KEGG" id="cpv:cgd8_3280"/>
    <dbReference type="InParanoid" id="A3FPZ4"/>
    <dbReference type="OMA" id="NIGANME"/>
    <dbReference type="OrthoDB" id="2129491at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016308">
        <property type="term" value="F:1-phosphatidylinositol-4-phosphate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00139">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.810.10">
        <property type="entry name" value="2-Layer Sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.800.10">
        <property type="entry name" value="Phosphatidylinositol Phosphate Kinase II Beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027483">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002498">
        <property type="entry name" value="PInositol-4-P-4/5-kinase_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027484">
        <property type="entry name" value="PInositol-4-P-5-kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023610">
        <property type="entry name" value="PInositol-4/5-P-5/4-kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086:SF8">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 5-PHOSPHATE 4-KINASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23086">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01504">
        <property type="entry name" value="PIP5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00330">
        <property type="entry name" value="PIPKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56104">
        <property type="entry name" value="SAICAR synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51455">
        <property type="entry name" value="PIPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="22"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="PIPK" evidence="5">
        <location>
            <begin position="440"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="828" mass="96338" checksum="BB3CD22B5D655C3F" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ08</accession>
    <name>A3FQ08_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_5050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388449.1">
        <property type="nucleotide sequence ID" value="XM_001388412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ08"/>
    <dbReference type="STRING" id="353152.A3FQ08"/>
    <dbReference type="GeneID" id="3374363"/>
    <dbReference type="KEGG" id="cpv:cgd8_5050"/>
    <dbReference type="InParanoid" id="A3FQ08"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="89"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="43"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="186" mass="22161" checksum="2A1ED998C0C2F5C1" modified="2007-04-03" version="1">MFALYKISLFKSFFTDAGRVPVTEEWRNTPDPKLIFERKDDGRLRFCKYELVYKPDRAHYCRQLNRNVLRMDHYCPWFGNCIGYFNYKFFFLALLYGCASLTYMMFSQINTLSNIWSDKNVTFGHLYLVSLGICFSAVLLIIVVPFFLFHAYITSRNETTIEFCEKRSKEKVSFYFILIINLYCAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ13</accession>
    <name>A3FQ13_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cathepsin like thiol protease possibly membrane associated, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388093.1">
        <property type="nucleotide sequence ID" value="XM_001388056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ13"/>
    <dbReference type="STRING" id="353152.A3FQ13"/>
    <dbReference type="GeneID" id="3373947"/>
    <dbReference type="KEGG" id="cpv:cgd3_680"/>
    <dbReference type="InParanoid" id="A3FQ13"/>
    <dbReference type="OMA" id="PPTCGSI"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="4">
        <location>
            <begin position="33"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="298" mass="33189" checksum="3F1C53BDAFB8005D" modified="2007-04-03" version="1" fragment="single">CKKEFGIKVSKVNKKKKRKLIILNLILYSPFRIPESFDLRSNEANRKNGGSCITFPDNQGKCANCYNFSALSAIEGATCRQLGKRIPPLSQQHSLDCWLQSKGSVKACSGGQTFEVFNYAIKSKVCTRDSYPSTTHKTGKLGECKSNCNECVGIKNFKWSYTGSSILYEDPWDVITDAIYNYGPVTVSVCSLMPGFNLYSGGYYEPPTCGSIWCGTRQVDHAVTLIGYGVSESGKRYYIMKNSWGLSWGNKGFMNISADMCSTFFNPGWVTSVSMDGISDYCLNREPDKNEIAHDFVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ28</accession>
    <name>A3FQ28_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_2310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388108.1">
        <property type="nucleotide sequence ID" value="XM_001388071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ28"/>
    <dbReference type="FunCoup" id="A3FQ28">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ28"/>
    <dbReference type="GeneID" id="3374077"/>
    <dbReference type="KEGG" id="cpv:cgd3_2310"/>
    <dbReference type="InParanoid" id="A3FQ28"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="16"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="86" mass="9700" checksum="35909CA5B52911A3" modified="2007-04-03" version="1" fragment="single">SICKVRNVKCIVLNSSIIYLRQLPYDISSTDLYDIFGRHGTIRQIRRGVGEDTKGTAFVVYDEIEDAKSALKQLSGFQVSGRYVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ82</accession>
    <name>A3FQ82_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribosomal RNA-processing protein 44</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_2090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNR ribonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388218.1">
        <property type="nucleotide sequence ID" value="XM_001388181.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ82"/>
    <dbReference type="FunCoup" id="A3FQ82">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ82"/>
    <dbReference type="GeneID" id="3373437"/>
    <dbReference type="KEGG" id="cpv:cgd2_2090"/>
    <dbReference type="InParanoid" id="A3FQ82"/>
    <dbReference type="OMA" id="GQVMRNN"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071031">
        <property type="term" value="P:nuclear mRNA surveillance of mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.700:FF:000001">
        <property type="entry name" value="Exosome complex exonuclease exoribonuclease (Rrp44)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041505">
        <property type="entry name" value="Dis3_CSD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022966">
        <property type="entry name" value="RNase_II/R_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033771">
        <property type="entry name" value="Rrp44_CSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF35">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RRP44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17849">
        <property type="entry name" value="OB_Dis3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17216">
        <property type="entry name" value="Rrp44_CSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01175">
        <property type="entry name" value="RIBONUCLEASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="RNB" evidence="12">
        <location>
            <begin position="544"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00077930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAZ51391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="922" mass="106270" checksum="2E3A3465929F6409" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ90</accession>
    <name>A3FQ90_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD-40 repeat protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_2880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388226.1">
        <property type="nucleotide sequence ID" value="XM_001388189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ90"/>
    <dbReference type="STRING" id="353152.A3FQ90"/>
    <dbReference type="GeneID" id="3373536"/>
    <dbReference type="KEGG" id="cpv:cgd2_2880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2880"/>
    <dbReference type="InParanoid" id="A3FQ90"/>
    <dbReference type="OMA" id="NIYDSTT"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="373" mass="41472" checksum="41941E71B309B1EA" modified="2007-04-03" version="1">MVENNDEIGNSIFFYKPWIPIMRISFKHNNEKYNESSIVRGVITINGQAAACGTDKGEIYVHSLETGKRILSHEKVGIKNYELGNGGLNDIKTDQSGNLLAACFSPGAISIYDLRAGIKKSGSLLGLTVMNLENTHEGACTCISVPNELLYQQIFSGGYDGYIRSWDLRKKGFVSQVLSHEAPVTSLEQSNDKRVLSSTSFDGKIRIWRSSNLKLLKTLSGPQGSNYSLHSIFSFNDEHLLCTGDSSSCIWKFGQEKTEKSNISWENSKKLQKDYYNNICDNNHLPMLTGFSVVWRDQVFVPRINPATAPVGDASVYCLHTAKYLYSLTPISPSNAIVTSISKHPDLNNNLIMTTSSLPEPSIVLWRLNEINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ91</accession>
    <name>A3FQ91_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Serine/threonine-protein phosphatase T</fullName>
            <ecNumber evidence="5">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">cgd2_2960</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:20630"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:47005"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="5"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388227.1">
        <property type="nucleotide sequence ID" value="XM_001388190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ91"/>
    <dbReference type="FunCoup" id="A3FQ91">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ91"/>
    <dbReference type="GeneID" id="3373546"/>
    <dbReference type="KEGG" id="cpv:cgd2_2960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2960"/>
    <dbReference type="InParanoid" id="A3FQ91"/>
    <dbReference type="OMA" id="IHKKYAF"/>
    <dbReference type="OrthoDB" id="445564at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07417">
        <property type="entry name" value="MPP_PP5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000036">
        <property type="entry name" value="Serine/threonine protein phosphatase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041753">
        <property type="entry name" value="PP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013235">
        <property type="entry name" value="PPP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051134">
        <property type="entry name" value="PPP_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45668:SF5">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08321">
        <property type="entry name" value="PPP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF033096">
        <property type="entry name" value="PPPtase_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 17" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="17">
        <location>
            <begin position="14"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="17">
        <location>
            <begin position="90"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="18">
        <location>
            <begin position="229"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="16">
        <location>
            <position position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00073946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR033096-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAZ51400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="525" mass="59589" checksum="468561D0E2131A32" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQB5</accession>
    <name>A3FQB5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal peptidase complex catalytic subunit SEC11</fullName>
            <ecNumber evidence="4">3.4.21.89</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Signal peptidase complex catalytic subunit sec11</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd1_440</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of hydrophobic, N-terminal signal or leader sequences from secreted and periplasmic proteins.</text>
            <dbReference type="EC" id="3.4.21.89"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the peptidase S26B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.89" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388137.1">
        <property type="nucleotide sequence ID" value="XM_001388100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQB5"/>
    <dbReference type="FunCoup" id="A3FQB5">
        <property type="interactions" value="351"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQB5"/>
    <dbReference type="MEROPS" id="S26.010"/>
    <dbReference type="GeneID" id="3371504"/>
    <dbReference type="KEGG" id="cpv:cgd1_440"/>
    <dbReference type="InParanoid" id="A3FQB5"/>
    <dbReference type="OMA" id="GSMEPFM"/>
    <dbReference type="OrthoDB" id="10257561at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009003">
        <property type="term" value="F:signal peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.109.10:FF:000003">
        <property type="entry name" value="Signal peptidase complex catalytic subunit SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015927">
        <property type="entry name" value="Peptidase_S24_S26A/B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001733">
        <property type="entry name" value="Peptidase_S26B"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02228">
        <property type="entry name" value="sigpep_I_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10806:SF6">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX CATALYTIC SUBUNIT SEC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00717">
        <property type="entry name" value="Peptidase_S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00728">
        <property type="entry name" value="SIGNALPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Peptidase S24/S26A/S26B/S26C" evidence="15">
        <location>
            <begin position="6"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00019685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00045533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAZ51314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="145" mass="16256" checksum="E9BBC81009D45A29" modified="2007-04-03" version="1">MLWRGLMVATNSQSPVVVVLSGSMEPGFYRGDILFLYNRKSITIGDIVVFSLEGRDIPIVHRVLSYHEGPNDGEISILTKGDNNDVDDRGLYNENQFWLNNKHIMGTAVGIIPKVGMITIWLNDYPWLKYALVGMMGITVLLGKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQG1</accession>
    <name>A3FQG1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Aspartyl (Acid) protease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd1_3690</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388183.1">
        <property type="nucleotide sequence ID" value="XM_001388146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQG1"/>
    <dbReference type="SMR" id="A3FQG1"/>
    <dbReference type="STRING" id="353152.A3FQG1"/>
    <dbReference type="GeneID" id="3371386"/>
    <dbReference type="KEGG" id="cpv:cgd1_3690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3690"/>
    <dbReference type="InParanoid" id="A3FQG1"/>
    <dbReference type="OMA" id="CAYDITY"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06096">
        <property type="entry name" value="Plasmepsin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033866">
        <property type="entry name" value="Plasmepsin_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032799">
        <property type="entry name" value="TAXi_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683">
        <property type="entry name" value="ASPARTYL PROTEASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683:SF375">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14541">
        <property type="entry name" value="TAXi_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="764"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="42"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="611"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="728"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="611"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="642"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="744"/>
            <end position="758"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAZ51360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="792" mass="88411" checksum="DB935F71EB456077" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQL7</accession>
    <name>A3FQL7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Small nuclear ribonucleoprotein Sm D2</fullName>
            <shortName evidence="10">Sm-D2</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">snRNP core protein D2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd4_3190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51260.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388072.1">
        <property type="nucleotide sequence ID" value="XM_001388035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQL7"/>
    <dbReference type="FunCoup" id="A3FQL7">
        <property type="interactions" value="506"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQL7"/>
    <dbReference type="GeneID" id="3372819"/>
    <dbReference type="KEGG" id="cpv:cgd4_3190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3190"/>
    <dbReference type="InParanoid" id="A3FQL7"/>
    <dbReference type="OMA" id="DVKEMWT"/>
    <dbReference type="OrthoDB" id="437526at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030532">
        <property type="term" value="C:small nuclear ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd01720">
        <property type="entry name" value="Sm_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000069">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027248">
        <property type="entry name" value="Sm_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12777">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="6" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="22"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAZ51260.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="106" mass="12013" checksum="5BD572552A410F6A" modified="2007-04-03" version="1">MTEDSNIESQTTKKDNPSEGPLSLLTECVKTNTQILVNCRNNRKILGRVKAFDRHCNLLLTDAREIWTESMKSGKKGSAKYINKDRFISKLFVRGDSVILILKSPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQQ2</accession>
    <name>A3FQQ2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">PEP5/VPS11 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_4010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAZ51214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388081.1">
        <property type="nucleotide sequence ID" value="XM_001388044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQQ2"/>
    <dbReference type="STRING" id="353152.A3FQQ2"/>
    <dbReference type="GeneID" id="3372415"/>
    <dbReference type="KEGG" id="cpv:cgd4_4010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4010"/>
    <dbReference type="InParanoid" id="A3FQQ2"/>
    <dbReference type="OMA" id="AYSYYIP"/>
    <dbReference type="OrthoDB" id="26184at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057308">
        <property type="entry name" value="CHCR_PEP5_VPS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057307">
        <property type="entry name" value="PEP5_VPS11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF24">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23341">
        <property type="entry name" value="PEP5_VPS11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23356">
        <property type="entry name" value="TPR_PEP5_VPS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PEP5/VPS11 N-terminal" evidence="9">
        <location>
            <begin position="5"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="554"/>
            <end position="581"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="738" mass="84781" checksum="407F97A1730E8377" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPG3</accession>
    <name>Q5CPG3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625330.1">
        <property type="nucleotide sequence ID" value="XM_625330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPG3"/>
    <dbReference type="GeneID" id="3372313"/>
    <dbReference type="KEGG" id="cpv:cgd3_160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_160"/>
    <dbReference type="InParanoid" id="Q5CPG3"/>
    <dbReference type="OMA" id="TIHNILY"/>
    <dbReference type="OrthoDB" id="339791at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="381"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="684" mass="78068" checksum="B4F8CB97C87B74A7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPH8</accession>
    <name>Q5CPH8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625371.1">
        <property type="nucleotide sequence ID" value="XM_625371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPH8"/>
    <dbReference type="GeneID" id="3375650"/>
    <dbReference type="KEGG" id="cpv:cgd6_360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_360"/>
    <dbReference type="InParanoid" id="Q5CPH8"/>
    <dbReference type="OrthoDB" id="337476at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="123" mass="14172" checksum="08FDF9AB334E99EA" modified="2005-04-12" version="1">MTARLRDSRNTIINSSFILNYENNNKLTINTSTINISLIVFTKDGHFRIYSCQDSPLFHNWSIIEQFTCNISINSYQMTSFSFINNLTIIENDIYNMNLIAIGSNNGMISIFIKLNSIMDDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPR6</accession>
    <name>Q5CPR6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_4330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625448.1">
        <property type="nucleotide sequence ID" value="XM_625448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPR6"/>
    <dbReference type="STRING" id="353152.Q5CPR6"/>
    <dbReference type="GeneID" id="3372388"/>
    <dbReference type="KEGG" id="cpv:cgd4_4330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4330"/>
    <dbReference type="InParanoid" id="Q5CPR6"/>
    <dbReference type="OMA" id="DMISHES"/>
    <dbReference type="OrthoDB" id="49395at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116907">
        <property type="entry name" value="Hook domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="210"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="318"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="528"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="581" mass="65885" checksum="7C2BD7EF8DA5EA46" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPS0</accession>
    <name>Q5CPS0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Possible gamma-tubulin complex 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_4290</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625444.1">
        <property type="nucleotide sequence ID" value="XM_625444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPS0"/>
    <dbReference type="GeneID" id="3372392"/>
    <dbReference type="KEGG" id="cpv:cgd4_4290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4290"/>
    <dbReference type="InParanoid" id="Q5CPS0"/>
    <dbReference type="OrthoDB" id="78652at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="7">
        <location>
            <begin position="434"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="774"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="824"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="781"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="837"/>
            <end position="847"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="879" mass="103575" checksum="EDDFA2A45C58CD0A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPZ2</accession>
    <name>Q5CPZ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625487.1">
        <property type="nucleotide sequence ID" value="XM_625487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPZ2"/>
    <dbReference type="GeneID" id="3372505"/>
    <dbReference type="KEGG" id="cpv:cgd8_240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_240"/>
    <dbReference type="InParanoid" id="Q5CPZ2"/>
    <dbReference type="OMA" id="MANGLHY"/>
    <dbReference type="OrthoDB" id="341400at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="174"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="335" mass="37741" checksum="4D8B73F379C4E0CE" modified="2005-04-12" version="1">MAITRRRGAEENRPKSTPSRSARRTKEEDVEFGLMEVIREKVYSISFLFKSMIPSWGLLLFWLFSALESSFFYIYVSLFSPLLRPLVFEGQGHKILMSYLGNQSFFPLLQKYKIISHIDQVFGWLSTWDQTNQLRFLAFCSSFIFGYVIYRGYEVCPTYSMVNYHLGKYPSFGIMMGSVISSTLGGVMGGILLFYLGNEYQIIPKYLLEGLKHGDYSLFPLSSFFGEALLSFLYSLGVSIVCRVGPGFFGAAEISWFSNANISIIASSMRAPGNLSLTYSALYGAYSGDYIGATILGIANITGTLLMNFLLMFRGSSIAKKTQVRRKTTTKSKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ02</accession>
    <name>Q5CQ02_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Vps72/YL1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS72/YL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625477.1">
        <property type="nucleotide sequence ID" value="XM_625477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ02"/>
    <dbReference type="STRING" id="353152.Q5CQ02"/>
    <dbReference type="GeneID" id="3372496"/>
    <dbReference type="KEGG" id="cpv:cgd8_130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_130"/>
    <dbReference type="InParanoid" id="Q5CQ02"/>
    <dbReference type="OMA" id="TGPTIRY"/>
    <dbReference type="OrthoDB" id="49520at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013272">
        <property type="entry name" value="Vps72/YL1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046757">
        <property type="entry name" value="YL1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275:SF4">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 72 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13275">
        <property type="entry name" value="YL-1 PROTEIN TRANSCRIPTION FACTOR-LIKE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05764">
        <property type="entry name" value="YL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08265">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00993">
        <property type="entry name" value="YL1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps72/YL1 C-terminal" evidence="3">
        <location>
            <begin position="373"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="186"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="122"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="449" mass="51934" checksum="CC24F2D311B833C6" modified="2005-04-12" version="1">MTQEYQKSNHDCDFDEGEASGDDVDEDVREVEMNIDEIEDEVTDDEGDESSEEGSEEDEELEKKVLPERASRGKRYTQLLGEEEEKDVKFWGHDTWEEEEEDSGWSSEDEKVELEILGGEDTSTDSENDSQSDDGMEEEMEAMAEDDDDDDVIDGKKPKKPKRMFSGKYKDPSLFLKSAQKEMLKKARKKASGIKKTGIVKKSPAALEPRTMSVRASTTQKKQDLQESIKRRDEEAQDRTNRKRLKKSSTSKEQAKTVMTQEERLEACKEIEKMNIESLNQLEAFEEHKRYLDNTSASIRKQLQSGSLNIYISWSSYRLMESEKNNSDEILNSDEYCREMIIYTDGNIPQHLDQKKDSNTNLHAKKEDGNYPPICSVYGVPAKYLDPLTNKYYSSLEAFKMIRKNYHASKYKEFLPEIREVQDLILETKKLIGEETQDYQLNNSFVKAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ23</accession>
    <name>Q5CQ23_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">MJ0710-like (Thump + methylase domains). RNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_4420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625603.1">
        <property type="nucleotide sequence ID" value="XM_625603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ23"/>
    <dbReference type="FunCoup" id="Q5CQ23">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ23"/>
    <dbReference type="GeneID" id="3372548"/>
    <dbReference type="KEGG" id="cpv:cgd5_4420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4420"/>
    <dbReference type="InParanoid" id="Q5CQ23"/>
    <dbReference type="OMA" id="AFNKWSR"/>
    <dbReference type="OrthoDB" id="296065at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043527">
        <property type="term" value="C:tRNA methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000241">
        <property type="entry name" value="RlmKL-like_Mtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059073">
        <property type="entry name" value="TRMT11_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370">
        <property type="entry name" value="RNA METHYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13370:SF3">
        <property type="entry name" value="TRNA (GUANINE(10)-N2)-METHYLTRANSFERASE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25904">
        <property type="entry name" value="Tmrp11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01170">
        <property type="entry name" value="UPF0020"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017259">
        <property type="entry name" value="tRNA_mtfrase_TRM11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00507">
        <property type="entry name" value="N12N6MTFRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA (guanine(10)-N(2))-methyltransferase TRMT11 N-terminal" evidence="4">
        <location>
            <begin position="59"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA large subunit methyltransferase K/L-like methyltransferase" evidence="3">
        <location>
            <begin position="232"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF25904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="501" mass="57657" checksum="1A6BCE90839ACD3A" modified="2005-04-12" version="1">MPLYLVWFVLHPDYHEFRLQELESLAECFGVEKNKLWVTNLPEYVSWHHRKYDRPLANDHSSSFAWVCLPNEDIALRILQRSVLVRGFMQVWASGTDHEQVEKVLKEDEYVKKEFLRKYIHDDVDFSWKVKSIGKKLSRPEQVSRMNHYSFLFKGTETVNLKDPSLSLGIFEDWRSIHNQEKLPIEGISKEQISKLQSTMLKRVYLGRIIENQSSTDLGDKSLWWLKYTLNKRPILGPTTMDNELAFIMCNIAQVKKNDIVFDPFCGTGGILISASHFGATCFGSDLDLRVINGWFCSYVNPHMIKDQSIKEDHSKSIYSNFDYYKLERPGIIRMDISQSSIRSSWIDAIVCDPPYGIRATSRTTNSNSNQPTSVYSGNNYIHTFIQDYNYRKSSPSSSSSSISNTHPSTGKNTFGSHQPIDEMIFDLLSFASKTLVIHGHLVFLLPLMVSDANIVIPNLIENWKHIFSIDFPYMQTLGGGLGRLLVHMKLINKNEELFGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ74</accession>
    <name>Q5CQ74_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_3880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625552.1">
        <property type="nucleotide sequence ID" value="XM_625552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ74"/>
    <dbReference type="GeneID" id="3372595"/>
    <dbReference type="KEGG" id="cpv:cgd5_3880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3880"/>
    <dbReference type="InParanoid" id="Q5CQ74"/>
    <dbReference type="OrthoDB" id="342488at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="418" mass="49697" checksum="384890258CC20196" modified="2005-04-12" version="1">MNKFENGLEHVKLRISNIEDEIYNITELRERNIIEKEKLEDEIYEIIEIEKILSELYDELYRISNFHEANNVLITRAFEEKLVKIFKEYYSNKLENLNNINFLDYEQIKYSYQNSRLSLINELKTNFGQDLLKIEVLNNIIKKLIASNEKIFYAIFKVEDLYKILLCFIYTDFLIWDPFSDSPNTDLLSFSSIINDVLKQDGVTTLNVSFFNTEKLVEKLYLEKLMNYICEIVKLYWTPFYFKETEKFVKSIRNVKDILEIDMSEVVSELMNKLQDNFNFLISESFLKPENEFKFVLLILNWAASVLMVTKAFQVKQEYINLLISKSILHFSQNSIQNHENKNLRKLLCETEIDVKEINDYSVNEQKLDSNILLNPKVAGLLNINEVLYQIKNSFKLNFPKKKYILIDIILEIISSYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="141" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQF0</accession>
    <name>Q5CQF0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA replication licensing factor MCM7</fullName>
            <ecNumber evidence="11">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="primary">MCM7</name>
        <name evidence="14" type="ORF">cgd4_970</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="11"/>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625698.1">
        <property type="nucleotide sequence ID" value="XM_625698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQF0"/>
    <dbReference type="FunCoup" id="Q5CQF0">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQF0"/>
    <dbReference type="GeneID" id="3372687"/>
    <dbReference type="KEGG" id="cpv:cgd4_970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_970"/>
    <dbReference type="InParanoid" id="Q5CQF0"/>
    <dbReference type="OMA" id="ISIHRAH"/>
    <dbReference type="OrthoDB" id="271325at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008050">
        <property type="entry name" value="MCM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF26">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24901">
        <property type="entry name" value="WHD_MCM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01663">
        <property type="entry name" value="MCMPROTEIN7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 11" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="13">
        <location>
            <begin position="381"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="608"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="608"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="644"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK87642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="857" mass="97188" checksum="311F38EEF17F4A15" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQH1</accession>
    <name>Q5CQH1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Extracellular protein with a signal peptide and 8 kazal repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_750</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625677.1">
        <property type="nucleotide sequence ID" value="XM_625677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQH1"/>
    <dbReference type="STRING" id="353152.Q5CQH1"/>
    <dbReference type="GeneID" id="3372745"/>
    <dbReference type="KEGG" id="cpv:cgd4_750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_750"/>
    <dbReference type="InParanoid" id="Q5CQH1"/>
    <dbReference type="OMA" id="SIAMCHE"/>
    <dbReference type="OrthoDB" id="343609at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050653">
        <property type="entry name" value="Prot_Inhib_GrowthFact_Antg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913:SF45">
        <property type="entry name" value="FOLLISTATIN, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10913">
        <property type="entry name" value="FOLLISTATIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0646">Protease inhibitor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0722">Serine protease inhibitor</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254120" evidence="4">
        <location>
            <begin position="21"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="30"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="147"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="211"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="5">
        <location>
            <begin position="284"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="688" mass="78255" checksum="4612F7469BEFB3AE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQH7</accession>
    <name>Q5CQH7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oocyst wall protein 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625671.1">
        <property type="nucleotide sequence ID" value="XM_625671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQH7"/>
    <dbReference type="GeneID" id="3372749"/>
    <dbReference type="KEGG" id="cpv:cgd4_670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_670"/>
    <dbReference type="InParanoid" id="Q5CQH7"/>
    <dbReference type="OMA" id="CTNACLS"/>
    <dbReference type="OrthoDB" id="337646at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254408" evidence="1">
        <location>
            <begin position="22"/>
            <end position="938"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="938" mass="106434" checksum="DD956ED35C0A21F3" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQJ9</accession>
    <name>Q5CQJ9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GDT1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the GDT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87729.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625649.1">
        <property type="nucleotide sequence ID" value="XM_625649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQJ9"/>
    <dbReference type="STRING" id="353152.Q5CQJ9"/>
    <dbReference type="GeneID" id="3372660"/>
    <dbReference type="KEGG" id="cpv:cgd4_420"/>
    <dbReference type="InParanoid" id="Q5CQJ9"/>
    <dbReference type="OMA" id="HAIACAM"/>
    <dbReference type="OrthoDB" id="442680at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015085">
        <property type="term" value="F:calcium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032468">
        <property type="term" value="P:Golgi calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032472">
        <property type="term" value="P:Golgi calcium ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001727">
        <property type="entry name" value="GDT1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12608">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN HTP-1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01169">
        <property type="entry name" value="GDT1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="49"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="220"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="252"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87729.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="273" mass="30246" checksum="7FBFC2D10E52FD87" modified="2005-04-12" version="1" fragment="single">LPLTKSKNSLKKMANIIKSFWMSLSSIFLSELGDKTFFISAILSMNNSAWIIFAGSMFALAGMTLFACLIGFILPNLFTPKYTHYASCVLFFIFGLKSLYEGLFLIESGNANNEFLEVKAELDKSRKKMSSITIDNKLEALDTGNMLFKDVELCNTRNNEEDLNVSSSKICMDECIKHRGLFRIIKNKSFIQAFTLTALAEWGDRSQIATILLSAYNDPFSVFFGSIIGHSICTGLACYGGKYLSKFISPRMVTISGGILFFAFAIGGIVMGP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQL3</accession>
    <name>Q5CQL3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">30 kDa splicing factor, SPF 30, tudor domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625635.1">
        <property type="nucleotide sequence ID" value="XM_625635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQL3"/>
    <dbReference type="STRING" id="353152.Q5CQL3"/>
    <dbReference type="GeneID" id="3372711"/>
    <dbReference type="KEGG" id="cpv:cgd4_270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_270"/>
    <dbReference type="InParanoid" id="Q5CQL3"/>
    <dbReference type="OMA" id="IGRTCSF"/>
    <dbReference type="OrthoDB" id="79171at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd04508">
        <property type="entry name" value="Tudor_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002999">
        <property type="entry name" value="Tudor"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00567">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00333">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63748">
        <property type="entry name" value="Tudor/PWWP/MBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50304">
        <property type="entry name" value="TUDOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tudor" evidence="2">
        <location>
            <begin position="144"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="9"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="285" mass="33458" checksum="E716D6BDF37E3F4E" modified="2005-04-12" version="1">MTRVNSKLMEIFQETYEELLKRFEDNQEQLRKIDEQLLKLTTDDPNYDILKEVRDDLIQVIQLVEELIDNKRKNSDENPEDVNIGKIVEVFYKGNKRFGRIKSKDPKSASNTINDYYLISIFGQIPETISLQFQDLKLLPQFKGLSVGEKVQVLFEEDGNWYNSVIVGLTKNGYNIKYLDYNQEENVTYDRVRMISKSSRNNLNHDKTIDSLDSTSIITTPAGYKIPENLLIKSYDTEKTKLEKKKKISVIKKQQKNEIFETQAKQKQQSWKNHISKFQKNSKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQL9</accession>
    <name>Q5CQL9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large low complexity coiled coil protein with large repeat region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625629.1">
        <property type="nucleotide sequence ID" value="XM_625629.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQL9"/>
    <dbReference type="GeneID" id="3372717"/>
    <dbReference type="KEGG" id="cpv:cgd4_200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_200"/>
    <dbReference type="InParanoid" id="Q5CQL9"/>
    <dbReference type="OMA" id="NKNENWK"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="542"/>
            <end position="1833"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="550"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="592"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="603"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="633"/>
            <end position="961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="977"/>
            <end position="988"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="989"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="999"/>
            <end position="1008"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1009"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1130"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1146"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1250"/>
            <end position="1260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1261"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1349"/>
            <end position="1371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1372"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1398"/>
            <end position="1437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1443"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1479"/>
            <end position="1494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1528"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1541"/>
            <end position="1623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1624"/>
            <end position="1634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1663"/>
            <end position="1678"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1708"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1721"/>
            <end position="1754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1763"/>
            <end position="1777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1810"/>
            <end position="1824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1833" mass="208839" checksum="E2C4A9559DC1AC64" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQT1</accession>
    <name>Q5CQT1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large low complexity protein with signal peptide, within large locus of signal peptide containing proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_3450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625921.1">
        <property type="nucleotide sequence ID" value="XM_625921.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372866"/>
    <dbReference type="KEGG" id="cpv:cgd4_3450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3450"/>
    <dbReference type="InParanoid" id="Q5CQT1"/>
    <dbReference type="OMA" id="LRCDNDS"/>
    <dbReference type="OrthoDB" id="342139at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254417" evidence="2">
        <location>
            <begin position="29"/>
            <end position="2929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1502"/>
            <end position="1521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1583"/>
            <end position="1675"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1690"/>
            <end position="1728"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1771"/>
            <end position="1808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1889"/>
            <end position="1912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="276"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="296"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="388"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="433"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1323"/>
            <end position="1333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1353"/>
            <end position="1363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1369"/>
            <end position="1401"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1408"/>
            <end position="1421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1422"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1449"/>
            <end position="1461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1502"/>
            <end position="1512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1583"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1646"/>
            <end position="1669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1698"/>
            <end position="1720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1781"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1798"/>
            <end position="1807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1889"/>
            <end position="1903"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2929" mass="338258" checksum="3050255D9C616A6B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQW6</accession>
    <name>Q5CQW6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_625886.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQW6"/>
    <dbReference type="GeneID" id="3372988"/>
    <dbReference type="KEGG" id="cpv:cgd4_3020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3020"/>
    <dbReference type="InParanoid" id="Q5CQW6"/>
    <dbReference type="OMA" id="CFIAFRF"/>
    <dbReference type="OrthoDB" id="339047at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254275" evidence="1">
        <location>
            <begin position="26"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="384" mass="44571" checksum="C9568BDF4F34F056" modified="2005-04-12" version="1">MLVRLAKLVIVIVFISQFTPNSCLTQNPFQPGYREVVPVEEKNSRTFLLRERADSSDIPLPNHFPNEPFYSTSDYTLDIKVKLAFYGDYINSDFENIKVKAKHGPRIINTCGHFVHKSLPPKYTIIVSLGGLSTHACSEESLKFFRKYINYISSIYGLEIVNSTQFIFLNWFYLVYHGSNDLYFSKKMVRYWISKPKKKDIIIPAVSSAAFINKLFRIGVIPSLSDTGAYGLCIGTLNIALASLLIKENMKVVVLNAPSFFWKNYLEDVLDDSLIGKKTTKYFILSGKSDRIFHYKRHGRKLSNFLSNYSDYVRYFKLDADHAELIITYIYTSMRMIATVLLDKKCSITYIKTKDYNKIPKSFSQSHWFRYVMYQLKESEHLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQY5</accession>
    <name>Q5CQY5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625867.1">
        <property type="nucleotide sequence ID" value="XM_625867.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQY5"/>
    <dbReference type="STRING" id="353152.Q5CQY5"/>
    <dbReference type="GeneID" id="3373001"/>
    <dbReference type="KEGG" id="cpv:cgd4_2820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2820"/>
    <dbReference type="InParanoid" id="Q5CQY5"/>
    <dbReference type="OrthoDB" id="343416at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="330" mass="38441" checksum="2A321201F5D6A9E2" modified="2005-04-12" version="1">MNSNVGSERKNVELNFANINLSNNSSSIKDSINLQDQNNLDNFFTENITISDSEDNISIESNFSENPIHQLDSTEKTRIYVPLSIETKDDNAFFLNRSKSLKDSKNQTKILSKQSADYIQSSEKRLKKNRKYRIKKDAINTEFEEKEKKHNKKSSFCCCLQTEDNKKNTNSTEDQAPKLSDFMEAKLQNAKVEEPTEQKSLEDKPKNTKDIGHKINKIQLEKELEKKSQFIETKLNIVNEKSPKSKSLENIYKIFEYKMNIEIPKFNDSMDLGFLSKRFGEKETNQNKPSSVKFPNFYEKTITEIISDTLSWYEMYKLNRVKRLEGILDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR09</accession>
    <name>Q5CR09_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative farnesyl pyrophosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_2550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="8 9" key="2">
        <citation type="journal article" date="2008" name="Chem. Biol." volume="15" first="1296" last="1306">
            <title>Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis.</title>
            <authorList>
                <person name="Artz J.D."/>
                <person name="Dunford J.E."/>
                <person name="Arrowood M.J."/>
                <person name="Dong A."/>
                <person name="Chruszcz M."/>
                <person name="Kavanagh K.L."/>
                <person name="Minor W."/>
                <person name="Russell R.G."/>
                <person name="Ebetino F.H."/>
                <person name="Oppermann U."/>
                <person name="Hui R."/>
            </authorList>
            <dbReference type="PubMed" id="19101474"/>
            <dbReference type="DOI" id="10.1016/j.chembiol.2008.10.017"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.37 ANGSTROMS) OF 38-384 IN COMPLEX WITH MG(2+)</scope>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625843.1">
        <property type="nucleotide sequence ID" value="XM_625843.1"/>
    </dbReference>
    <dbReference type="PDB" id="2O1O">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.42 A"/>
        <property type="chains" value="A/B=38-384"/>
    </dbReference>
    <dbReference type="PDB" id="2Q58">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.37 A"/>
        <property type="chains" value="A/B=38-384"/>
    </dbReference>
    <dbReference type="PDBsum" id="2O1O"/>
    <dbReference type="PDBsum" id="2Q58"/>
    <dbReference type="AlphaFoldDB" id="Q5CR09"/>
    <dbReference type="SMR" id="Q5CR09"/>
    <dbReference type="FunCoup" id="Q5CR09">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR09"/>
    <dbReference type="BindingDB" id="Q5CR09"/>
    <dbReference type="GeneID" id="3372978"/>
    <dbReference type="KEGG" id="cpv:cgd4_2550"/>
    <dbReference type="InParanoid" id="Q5CR09"/>
    <dbReference type="OMA" id="CSWVVNQ"/>
    <dbReference type="OrthoDB" id="10257492at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CR09"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004337">
        <property type="term" value="F:(2E,6E)-farnesyl diphosphate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004161">
        <property type="term" value="F:dimethylallyltranstransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045337">
        <property type="term" value="P:farnesyl diphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039702">
        <property type="entry name" value="FPS1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525:SF0">
        <property type="entry name" value="FARNESYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11525">
        <property type="entry name" value="FARNESYL-PYROPHOSPHATE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00005">
        <property type="entry name" value="Isoprenoid_Synthase_Type_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01017">
        <property type="entry name" value="Polyprenyl_Transferase_Like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8 9">
        <location>
            <position position="203"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="270"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="271"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="2O1O"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="2Q58"/>
        </source>
    </evidence>
    <sequence length="384" mass="44964" checksum="9BA091557A0FDF74" modified="2005-04-12" version="1" fragment="single">ILFHLLKITFIDSIFFALHDNYLTPQFIFNKMNDLQIEYDYTDFINYYDKFKVIVYNVLKKLPLNDEIRKPVIEYYLNCIDYNVKKGKHIRGKILVLISSLSSAYSNIKRDSIYLLGWVVEAIQALILIADDIMDSGKFRRGAPCWYIVHGQSNAINDIFFLKMLSLSLIFELSSVFGNDIVMKIQKIYNESIFFTVLGQHLDLSYFDLSKADKISERYFSMVEMKTSRYTFYMPVFFGLTLSEIQVSSAQLNLIEAILYKLGEFYQVHNDVSDYLFNDSNADDICRFKLTWPLQKSFEIADEEMKLKISENYGKNSSLVKDCYNLLKINEHYLEYQRNALDYLIKLVKDITDDSLQKVFIHLIHQISELITNSRSNADSNNSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR11</accession>
    <name>Q5CR11_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transmembrane domain near C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625841.1">
        <property type="nucleotide sequence ID" value="XM_625841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR11"/>
    <dbReference type="GeneID" id="3372853"/>
    <dbReference type="KEGG" id="cpv:cgd4_2530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2530"/>
    <dbReference type="InParanoid" id="Q5CR11"/>
    <dbReference type="OrthoDB" id="337418at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="230" mass="26525" checksum="367F06AB784BB448" modified="2005-04-12" version="1">MANIGNEENHIFSIIEIFIKKNHKQYVLNSIRINSLVRIFNGVTPEILLNLLKNAGKNTEEGDSKIYACSNTTDVQKVLCFISKDIVTFKFHNTPDITLARYFFQFDECHIILCNCCYKESYNLNTFDLIFYIQNQDFGRSNESHNSKMTLISGSSGKSFTNKCMVPFGSVLTNYGTIYLIYSLFAWLVYILIAIKRYLSTKVSEEEIEKLFIKNYISNLDIQTCKKGNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR25</accession>
    <name>Q5CR25_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vacuolar protein sorting-associated protein 35</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_2390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Plays a role in vesicular protein sorting.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the VPS35 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625827.1">
        <property type="nucleotide sequence ID" value="XM_625827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR25"/>
    <dbReference type="FunCoup" id="Q5CR25">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR25"/>
    <dbReference type="GeneID" id="3372885"/>
    <dbReference type="KEGG" id="cpv:cgd4_2390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2390"/>
    <dbReference type="InParanoid" id="Q5CR25"/>
    <dbReference type="OMA" id="YIRSREY"/>
    <dbReference type="OrthoDB" id="10258141at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030906">
        <property type="term" value="C:retromer, cargo-selective complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.660">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 35, helical subcomplex Vps35-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005378">
        <property type="entry name" value="Vps35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042491">
        <property type="entry name" value="Vps35_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11099">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03635">
        <property type="entry name" value="Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF009375">
        <property type="entry name" value="Retromer_Vps35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="809" mass="92516" checksum="588FBB890F20ECA5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR40</accession>
    <name>Q5CR40_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative double-stranded DNA-binding domain, small conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PDCD5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625812.1">
        <property type="nucleotide sequence ID" value="XM_625812.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR40"/>
    <dbReference type="FunCoup" id="Q5CR40">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR40"/>
    <dbReference type="GeneID" id="3372953"/>
    <dbReference type="KEGG" id="cpv:cgd4_2220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2220"/>
    <dbReference type="InParanoid" id="Q5CR40"/>
    <dbReference type="OMA" id="QAENQEN"/>
    <dbReference type="OrthoDB" id="10252486at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.140">
        <property type="entry name" value="PDCD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002836">
        <property type="entry name" value="PDCD5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036883">
        <property type="entry name" value="PDCD5-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10840:SF0">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01984">
        <property type="entry name" value="dsDNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015730">
        <property type="entry name" value="TFAR19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46950">
        <property type="entry name" value="Double-stranded DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="130" mass="15070" checksum="C722AFC6B316C395" modified="2005-04-12" version="1">MNISDPNEFNSGKNGSNNVGPIETNQEFNQKVDDQKRIIEDQKRGALRAILENSSIERLNRIALVKPDKVLQIEDYILRTARNHGYSPYRKIQESELINMISMMNETTEKSSSRIKICRKGVFDDDDYEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRH0</accession>
    <name>Q5CRH0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Actin depolymerizing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_2800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the actin-binding proteins ADF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626216.1">
        <property type="nucleotide sequence ID" value="XM_626216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRH0"/>
    <dbReference type="SMR" id="Q5CRH0"/>
    <dbReference type="FunCoup" id="Q5CRH0">
        <property type="interactions" value="63"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRH0"/>
    <dbReference type="GeneID" id="3373209"/>
    <dbReference type="KEGG" id="cpv:cgd5_2800"/>
    <dbReference type="InParanoid" id="Q5CRH0"/>
    <dbReference type="OMA" id="QCRFAVY"/>
    <dbReference type="OrthoDB" id="10249245at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015629">
        <property type="term" value="C:actin cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030042">
        <property type="term" value="P:actin filament depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11286">
        <property type="entry name" value="ADF_cofilin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002108">
        <property type="entry name" value="ADF-H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017904">
        <property type="entry name" value="ADF/Cofilin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11913">
        <property type="entry name" value="COFILIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00241">
        <property type="entry name" value="Cofilin_ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00102">
        <property type="entry name" value="ADF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55753">
        <property type="entry name" value="Actin depolymerizing proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51263">
        <property type="entry name" value="ADF_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ADF-H" evidence="3">
        <location>
            <begin position="3"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51263"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="135" mass="15671" checksum="FB42E3DA9383E147" modified="2005-04-12" version="1" fragment="single">KMSSGVKIHQDCIDAFQKQKIRKQHRYLLYKMDSTYENIILFKTSGPEETYEDFLKSIPETECFYATIDLPDPNGQTPKLIFLMFTPENAKVKDRMVFASSKDGFVKKLEGVHGKLLQASERSDLDYKLVADQYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRM0</accession>
    <name>Q5CRM0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626166.1">
        <property type="nucleotide sequence ID" value="XM_626166.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRM0"/>
    <dbReference type="STRING" id="353152.Q5CRM0"/>
    <dbReference type="GeneID" id="3373121"/>
    <dbReference type="KEGG" id="cpv:cgd5_2290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2290"/>
    <dbReference type="InParanoid" id="Q5CRM0"/>
    <dbReference type="OrthoDB" id="342354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254296" evidence="1">
        <location>
            <begin position="26"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="402" mass="46972" checksum="B1622EA22315A47C" modified="2005-04-12" version="1">MIFLGVYYFAILLLFSILENKFGIAHDTKFHHENKTKVIEFNDKSNKTLFPIDAADLLECSKYNGYILLDKTSQVTKNETHTNKLLPLENIYLSSHFFGIMESIAGTSGDFVNDAISGLQINRVVQALKETRIQLYLGNFQDSPKIMPKKLSSINLSCIYGNYLPSLNFYHFNNFCEFTQCINNDYLLLSEDHICNYKYSEKYMYGDKMKYFNVLASLNIPIINYLEFDQQFITLFNAHNIYNDQMIHLNRYLLLSNELGLSLFINFGIRFFGKLESDKYYLLIKIVPPNTFWIKDEYKNLEENSKENKVINPESCTKYENGTRFFEKNTVSVIETDKKSNNLIVNRNSVTYLNISFNKIIKCLGKYSINIYTRSSDGKSLIIKIFDKENNEFRDLEMIENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRQ0</accession>
    <name>Q5CRQ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large low complexity protein with predicted coiled coil regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626136.1">
        <property type="nucleotide sequence ID" value="XM_626136.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRQ0"/>
    <dbReference type="GeneID" id="3373269"/>
    <dbReference type="KEGG" id="cpv:cgd5_1940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1940"/>
    <dbReference type="InParanoid" id="Q5CRQ0"/>
    <dbReference type="OMA" id="FRSEQMN"/>
    <dbReference type="OrthoDB" id="343920at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1539"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1758"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1862"/>
            <end position="1914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1946"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1982"/>
            <end position="2511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1539"/>
            <end position="1564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1772"/>
            <end position="1790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1864"/>
            <end position="1877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1891"/>
            <end position="1903"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1990"/>
            <end position="2003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2028"/>
            <end position="2044"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2055"/>
            <end position="2065"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2085"/>
            <end position="2102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2103"/>
            <end position="2112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2132"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2184"/>
            <end position="2193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2325"/>
            <end position="2334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2406"/>
            <end position="2416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2440"/>
            <end position="2450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="2488"/>
            <end position="2497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2511" mass="284297" checksum="EACC9E3B709C44BB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRR8</accession>
    <name>Q5CRR8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Conserved protein, possible U4/U6 associated RNA splicing factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_1740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626118.1">
        <property type="nucleotide sequence ID" value="XM_626118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRR8"/>
    <dbReference type="STRING" id="353152.Q5CRR8"/>
    <dbReference type="GeneID" id="3373011"/>
    <dbReference type="KEGG" id="cpv:cgd5_1740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1740"/>
    <dbReference type="InParanoid" id="Q5CRR8"/>
    <dbReference type="OMA" id="CVMHPRF"/>
    <dbReference type="OrthoDB" id="10264544at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24162">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013881">
        <property type="entry name" value="Pre-mRNA_splic_Prp3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027104">
        <property type="entry name" value="Prp3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212">
        <property type="entry name" value="U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14212:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08572">
        <property type="entry name" value="PRP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor 3" evidence="7">
        <location>
            <begin position="113"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="6">
        <location>
            <begin position="336"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="452" mass="53016" checksum="6F77069C0D4401FB" modified="2005-04-12" version="1">MFEIKNNELSSNKSEATQLNSSHDDKLLLEKAKKALAIQSRIEKNLSILHSKADVNELIIKTTENGHLNLENNYTLVSSKPTSNSEHKFSCIEALNVKEPKLNSIAQKRCTEFTDPRLIIKQKSKKALRFIRKGVFSRAEIELNDPDLVSRKKRRQVEELFFLNDESVFSKVLIPELEHWDMPFVKPKENVSEDEFPFEILVSKISNLIEHPVPLEPYFDPDENVSSVIFLTKKEKARLRRMNRQEKEMERQDRIRMGIESPLRPILKLSNLHNILNEKVVAEPSNIELEIKKQKEERIKLHEDRNAPLKHNQEDKCKKKENKWKLDQNNPIVHAAIFKIGSLKNKRYIFKIDRNAHDCHLTGCCVISSIDPCIILVEGSKKSIKFYKNLLLNRIKWDQPIETTTSCSLIWEGVRPSRIFFRWKIYYCHSKEDAYRFFLDNNSLDLWNISQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRV9</accession>
    <name>Q5CRV9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Tfc4p like TFIIIC subunit TPR repeat containing basal transcription factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_1280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626077.1">
        <property type="nucleotide sequence ID" value="XM_626077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRV9"/>
    <dbReference type="STRING" id="353152.Q5CRV9"/>
    <dbReference type="GeneID" id="3373295"/>
    <dbReference type="KEGG" id="cpv:cgd5_1280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1280"/>
    <dbReference type="InParanoid" id="Q5CRV9"/>
    <dbReference type="OMA" id="SSPNMKF"/>
    <dbReference type="OrthoDB" id="9991317at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039340">
        <property type="entry name" value="Tfc4/TFIIIC-102/Sfc4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23082">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIIC TFIIIC , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="933" mass="107476" checksum="3B3EA2AD85545B03" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS54</accession>
    <name>Q5CS54_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Rdx family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625982.1">
        <property type="nucleotide sequence ID" value="XM_625982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS54"/>
    <dbReference type="STRING" id="353152.Q5CS54"/>
    <dbReference type="GeneID" id="3373197"/>
    <dbReference type="KEGG" id="cpv:cgd5_180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_180"/>
    <dbReference type="InParanoid" id="Q5CS54"/>
    <dbReference type="OMA" id="VFVRPIC"/>
    <dbReference type="OrthoDB" id="60822at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004791">
        <property type="term" value="F:thioredoxin-disulfide reductase (NADPH) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011893">
        <property type="entry name" value="Selenoprotein_Rdx-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019389">
        <property type="entry name" value="Selenoprotein_T"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544">
        <property type="entry name" value="SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13544:SF0">
        <property type="entry name" value="THIOREDOXIN REDUCTASE-LIKE SELENOPROTEIN T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10262">
        <property type="entry name" value="Rdx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="101"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="207" mass="22743" checksum="36F341984F452B59" modified="2005-04-12" version="1">MKKVSTIFSAIIISLIAIGVGLVKFNYLNISEYGLLEKLITPQNEIPDDVGPKTMTIQYCDTCGTRNLYQQVQSYLSSRVTDPDFQLIAVKYKPSPLYQGLSYAITASQVGLGLSAFLFPSLFTPTDQQGQPQGGPRTHLMMLIFFGGNILRGLFTNSNAFEIYLGKDLVYSAIQNNSSGYATPPTLEQVVTILNEHGISVLETLTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS76</accession>
    <name>Q5CS76_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_3800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628191.1">
        <property type="nucleotide sequence ID" value="XM_628191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS76"/>
    <dbReference type="GeneID" id="3371729"/>
    <dbReference type="KEGG" id="cpv:cgd1_3800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3800"/>
    <dbReference type="InParanoid" id="Q5CS76"/>
    <dbReference type="OMA" id="INITHIY"/>
    <dbReference type="OrthoDB" id="408098at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="190" mass="21962" checksum="1A746B00502F8F59" modified="2005-04-12" version="1">MFSCFRSCSESPFCLLFGFKEEKSNNYGTDRSQRALSSKMSEASDVKEKKKKQKQLFNRRTADEILTICRSWENYIHPRAKDFWKSSEQVYEILSNIASNIDRSDDPITSGEEQCVRWHGELEAEDGAPVIRILKPGETDECQTYVNRILAFLYADDESFLELQKKPPVAFKNVCEDPICINLTHISLEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS93</accession>
    <name>Q5CS93_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor TAF7p/TAFII55</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_3620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628174.1">
        <property type="nucleotide sequence ID" value="XM_628174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS93"/>
    <dbReference type="STRING" id="353152.Q5CS93"/>
    <dbReference type="GeneID" id="3371524"/>
    <dbReference type="KEGG" id="cpv:cgd1_3620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3620"/>
    <dbReference type="InParanoid" id="Q5CS93"/>
    <dbReference type="OMA" id="CNIEAYK"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051123">
        <property type="term" value="P:RNA polymerase II preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08047">
        <property type="entry name" value="TAF7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037817">
        <property type="entry name" value="TAF7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006751">
        <property type="entry name" value="TAFII55_prot_cons_reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228:SF0">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN ASSOCIATED FACTOR 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12228">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID 55 KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04658">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01370">
        <property type="entry name" value="TAFII55_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="TAFII55 protein conserved region" evidence="6">
        <location>
            <begin position="37"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="368" mass="42271" checksum="BCBA87E76B7EF972" modified="2005-04-12" version="1">MGISKAERQLQFVPQRYLRRGIFSSVDLSSSIYSALPESVCVVKIPDAISKEVNSLLSRGEKFPFGIQPTPFEDFRIFDIYLLGQDYVGILVDLPCNIEVYKSLDCESMFKSNNLNQMLYIYDANCLPKWFITSQGVNISSIYKGPMKSNMMYSDQTFVSFIKYLRESLHWEWPAGLLPASRGVRSRKYRNTELFDIGEVIEAEQELLDRVSMPSQDMVTIDVISTKEMDEQIHLFKHEQKNSPFPIASVFDKKKKATCMGIIGRDDDLRSMISRFKREDSQKKGAKQNTLEFDDIQSDISDVIFRESSDDENNPDNNLEMEPNNVRISEENLSKTTIRENSSNNKLVISNELSLNEDWDSHDSSSDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSF6</accession>
    <name>Q5CSF6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_2930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628111.1">
        <property type="nucleotide sequence ID" value="XM_628111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSF6"/>
    <dbReference type="GeneID" id="3371715"/>
    <dbReference type="KEGG" id="cpv:cgd1_2930"/>
    <dbReference type="InParanoid" id="Q5CSF6"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="134" mass="14982" checksum="86B5AC1E0703779A" modified="2005-04-12" version="1">MVIPTVEFSIRVLFINVKGHGIQYGTLGKSSLKSNVGLSTIIQQSLKSLMKGCQVKFPMELVNIKEFNYKSSVEKYSPIISKNLASMVMRSDSIVFKNGLFEILSRCDPENSTNLSDLLGRFCVVNHTIKNISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSH7</accession>
    <name>Q5CSH7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anaphase-promoting complex subunit 11</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd1_2640</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628090.1">
        <property type="nucleotide sequence ID" value="XM_628090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSH7"/>
    <dbReference type="FunCoup" id="Q5CSH7">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSH7"/>
    <dbReference type="GeneID" id="3371350"/>
    <dbReference type="KEGG" id="cpv:cgd1_2640"/>
    <dbReference type="InParanoid" id="Q5CSH7"/>
    <dbReference type="OMA" id="QWRWDTG"/>
    <dbReference type="OrthoDB" id="1681166at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097602">
        <property type="term" value="F:cullin family protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16456">
        <property type="entry name" value="RING-H2_APC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024991">
        <property type="entry name" value="RING-H2_APC11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12861">
        <property type="entry name" value="zf-ANAPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="10">
        <location>
            <begin position="56"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="117" mass="13576" checksum="8EB5A6565EBB2C5B" modified="2005-04-12" version="1" fragment="single">FTISRSYICKYYELTPSIETEMARIKINKLRMIGYWNWLCGDDLCSICSESFELTCPQCFKPGDSCPPAFGECGHSFHLHCIHEWLSRARNDSGMCPMCRREFKFQSNANILQSTNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSX7</accession>
    <name>Q5CSX7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627940.1">
        <property type="nucleotide sequence ID" value="XM_627940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSX7"/>
    <dbReference type="GeneID" id="3371561"/>
    <dbReference type="KEGG" id="cpv:cgd1_940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_940"/>
    <dbReference type="InParanoid" id="Q5CSX7"/>
    <dbReference type="OMA" id="HIWCIES"/>
    <dbReference type="OrthoDB" id="337844at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="179" mass="20774" checksum="6EC559E894F66997" modified="2005-04-12" version="1">MDNDRSISMSYIDLGSDSPTSKESCPSNLEYIIELVIYSQLVISLFLCIGRTDYNFTLYLLGYGVFCVEMPPLDVNGLIRKITGIRRFLMLIILATAIEAIWLSFAVSAWLCPNNQNPDVCFVEDFQMNWEYKLHQYIIWGSSINFILKLVLGTLCWMWIDKERTKLEAISLKPLIFFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSZ9</accession>
    <name>Q5CSZ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted secreted protein, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627918.1">
        <property type="nucleotide sequence ID" value="XM_627918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSZ9"/>
    <dbReference type="GeneID" id="3371540"/>
    <dbReference type="KEGG" id="cpv:cgd1_660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_660"/>
    <dbReference type="InParanoid" id="Q5CSZ9"/>
    <dbReference type="OMA" id="PPCFCAN"/>
    <dbReference type="OrthoDB" id="340690at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254493" evidence="2">
        <location>
            <begin position="19"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="338" mass="37103" checksum="DECB9F12CEA609A0" modified="2005-04-12" version="1">MKLLAILFLFELIFRATAQDVILESEEGHQNKDDNGIADSDSNTEVTKVPNFILLCALIPQIPGCPCDPLLETRPTFYDFLPSDCSCYDSQQSGFSSPPCFCSKPDSDECKCLSGLSSLDEEHDRMCIVSPLTYVTPYANCTSFLNPLGEEGLCSGDSELSEHCVTLKSCRRLTPISIEESSIQDKCVTDPESEGCPCSADQQITDEDALICSCYKNNKNPGCPCDVQPDSSICQKFIDLLTKPTSSSSTTTTSEPIEIMNSKETEPDTKNIENKTKSSVKETEDDKTKEIDDIVPHNETIMKDAGNDSGKNDSSFAFKVSTSLYIPVIFVLLSTLIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT08</accession>
    <name>Q5CT08_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd1_520</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627909.1">
        <property type="nucleotide sequence ID" value="XM_627909.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT08"/>
    <dbReference type="FunCoup" id="Q5CT08">
        <property type="interactions" value="138"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT08"/>
    <dbReference type="GeneID" id="3371548"/>
    <dbReference type="KEGG" id="cpv:cgd1_520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_520"/>
    <dbReference type="InParanoid" id="Q5CT08"/>
    <dbReference type="OMA" id="MSVCPPY"/>
    <dbReference type="OrthoDB" id="433895at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="14"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="93"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="165" mass="16873" checksum="79E274F83F6E85E0" modified="2005-04-12" version="1">MITCDPNSLFFGFLGIAGCLIFANLGAAYGIAKSGVGISSMAVMRPDLIMRSIIPAVMAGILGIYGLIGSLVIFFQMGEPNLYSAYTAYAQMSAGLVIGLSSLAAGLAIGIVGDAGVRAAAQQPRLLTGMILILVFGEALAIYGVIIGIIMGTTKPTGQLCASYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT21</accession>
    <name>Q5CT21_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627896.1">
        <property type="nucleotide sequence ID" value="XM_627896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT21"/>
    <dbReference type="STRING" id="353152.Q5CT21"/>
    <dbReference type="GeneID" id="3371421"/>
    <dbReference type="KEGG" id="cpv:cgd1_360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_360"/>
    <dbReference type="InParanoid" id="Q5CT21"/>
    <dbReference type="OMA" id="KRCYSSH"/>
    <dbReference type="OrthoDB" id="2414723at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030690">
        <property type="term" value="C:Noc1p-Noc2p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030691">
        <property type="term" value="C:Noc2p-Noc3p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005343">
        <property type="entry name" value="Noc2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687">
        <property type="entry name" value="NUCLEOLAR COMPLEX 2 AND RAD4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12687:SF4">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03715">
        <property type="entry name" value="Noc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="749"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="836" mass="97852" checksum="B4B11DDF10C3F734" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTE8</accession>
    <name>Q5CTE8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Iowa type II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626521.1">
        <property type="nucleotide sequence ID" value="XM_626521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTE8"/>
    <dbReference type="GeneID" id="3373763"/>
    <dbReference type="KEGG" id="cpv:cgd2_3310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3310"/>
    <dbReference type="InParanoid" id="Q5CTE8"/>
    <dbReference type="OMA" id="NIPWIAN"/>
    <dbReference type="OrthoDB" id="342183at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="465"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="823" mass="94989" checksum="158CEEE2DB47B7D4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTJ8</accession>
    <name>Q5CTJ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Brf1p like coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_2700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626471.1">
        <property type="nucleotide sequence ID" value="XM_626471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTJ8"/>
    <dbReference type="FunCoup" id="Q5CTJ8">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTJ8"/>
    <dbReference type="GeneID" id="3373631"/>
    <dbReference type="KEGG" id="cpv:cgd2_2700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2700"/>
    <dbReference type="InParanoid" id="Q5CTJ8"/>
    <dbReference type="OMA" id="AHWKEDQ"/>
    <dbReference type="OrthoDB" id="10261749at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042175">
        <property type="term" value="C:nuclear outer membrane-endoplasmic reticulum membrane network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008298">
        <property type="term" value="P:intracellular mRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039604">
        <property type="entry name" value="Bfr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055545">
        <property type="entry name" value="DUF7121"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027:SF2">
        <property type="entry name" value="LEBERCILIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31027">
        <property type="entry name" value="NUCLEAR SEGREGATION PROTEIN BFR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23435">
        <property type="entry name" value="DUF7121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="81"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="208"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="356"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="495" mass="57188" checksum="71BE6A3AC8C3EEDE" modified="2005-04-12" version="1">MVAVVSSDSHKERQSNRPRFITPVSAAEKSIPVVPAPDEKTYKETTEAIRQVLNEWNIKIRGLTKMINDRSVGREAFDRKKSEFQAKLDEYQKCIENLEEERKLCMAKINEKSKEGREMKANLQSLKKSVGYKSEEEIEAKIKEIEYQLVTSTLSLKDEKKLLSQISQLKQSRPIVGRFAHMDASASSFEENSIIPLRAKISSIIEDLNKFRKQKKEVFDKLRALTADRQKALEPLRSLYDERSAMQSKVEEQHTKLRQLREEYDREMKLFMEYQSKLRALRSERVKEEKILRDLYRQRDDLRLALEQEDDPPISTEMQLVQQSLSYIQKLMESHGVIDKTSQSTKDKATLSDESKNLSASAIKGRDKDESVLLPKNQRNEEYLIPPKGKKNKRRQNSSSNNSSSAHKSLVVDFATISTFEKVDLDVPMTTDDLPKAYSLLLEKHLKLKSEFDEKFANREKRKEEILKKLGDIELKITEAGGILEDAVSSPKIEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTT0</accession>
    <name>Q5CTT0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_1700</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626389.1">
        <property type="nucleotide sequence ID" value="XM_626389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTT0"/>
    <dbReference type="STRING" id="353152.Q5CTT0"/>
    <dbReference type="GeneID" id="3373677"/>
    <dbReference type="KEGG" id="cpv:cgd2_1700"/>
    <dbReference type="InParanoid" id="Q5CTT0"/>
    <dbReference type="OMA" id="IQTIFHL"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0007">Acetylation</keyword>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="21"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="6">
        <location>
            <begin position="104"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="172" mass="18978" checksum="9DE6494FF6CB4DA9" modified="2005-04-12" version="1" fragment="single">IEILKMNESSTHIQSKKIPQNRISDIQTIFHLFDKDKDGSISGSDLFETFKSIGLDIPPQQIDVLLNEIKGRASTGMQQDPAISSSIDCAMFSGFISRQLDSAPLSEQLRETFSLLDINGDGYITPECLAEVCSKLGVSLTDQDARQLMVQSDGQAKADYNKFVKLMQLSKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTW5</accession>
    <name>Q5CTW5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_1290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626354.1">
        <property type="nucleotide sequence ID" value="XM_626354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTW5"/>
    <dbReference type="GeneID" id="3373579"/>
    <dbReference type="KEGG" id="cpv:cgd2_1290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1290"/>
    <dbReference type="InParanoid" id="Q5CTW5"/>
    <dbReference type="OMA" id="WIPFNIE"/>
    <dbReference type="OrthoDB" id="339591at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="313"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="132"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="165"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="187"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="422" mass="49120" checksum="4E70C1D7B2F2ADD0" modified="2005-04-12" version="1">MKSLPLINYSTIFIFLYSCFTVFNYATCELFIVNSKATNQTNDSWFNLDLLREFLMDENVTSSSTDVFEGFKKMIKVSPPTPKTKSSSWIPQNIKDVISRINSNSKKEEVKHKPILKRKFEDLKHYLEYHLYPENPQNNTKPEERGRNMFSFGFTGKNLNEQNNKKSTIQSSESSSKEQALIEQKLEGTTQNTNNMKETSNQNTPSSPSPELPADQCEKNVINMFKDCIERCKSNLKQAQYKSGGISPLIVSELNTCIHTCRHSANSSNCKLSANSINLINQEIPVPKPTIRRNQKNQEKSRGLLSKYIIDPIVSFITTCLFCLLGIIVVLYYFKEYRFYPRMADYITYKIESYYTEDEKRRAIFEGDGFPQQPKVNWKRTIVYFVRLNYLPRVLANNFTWLIPMRDHYQQVTDPSNYVRVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTY6</accession>
    <name>Q5CTY6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_1050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626333.1">
        <property type="nucleotide sequence ID" value="XM_626333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTY6"/>
    <dbReference type="GeneID" id="3373596"/>
    <dbReference type="KEGG" id="cpv:cgd2_1050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1050"/>
    <dbReference type="InParanoid" id="Q5CTY6"/>
    <dbReference type="OMA" id="TEINCIC"/>
    <dbReference type="OrthoDB" id="342790at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="347" mass="39565" checksum="AD1B86CEFBF54C28" modified="2005-04-12" version="1">MLAWIKLMFSIYIIFYIIFFYIQVVYSLYSNLSKGANNHKYFILNPIQYNDFVLNIIKNSEETSSESSFRRSDNLNQIISSQIKNIICKESDLVFSNTETNVGHSTILNLTTSDSKTNGNSDYLLLFGADRCILDSSFIDGKFTKINIRFIPNLANPTKEVYQDKICDCVFKKGNADEGSPSEFQVNCNSDSSNDSNKKVPEEHNYLEIGGAATLNIADLVNLPTPIIDKNSQVGRQVKVEVSNKSPLKPIIKPNHIKASKPKVNKFNFSKYFWETNSGFFGEGQEAIKKSNIEYCESHSQSKSCEDEERSRIEREFREGCNSKEHQLILETLLIIVNKLVEYLDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTZ8</accession>
    <name>Q5CTZ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626321.1">
        <property type="nucleotide sequence ID" value="XM_626321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTZ8"/>
    <dbReference type="GeneID" id="3373605"/>
    <dbReference type="KEGG" id="cpv:cgd2_890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_890"/>
    <dbReference type="InParanoid" id="Q5CTZ8"/>
    <dbReference type="OrthoDB" id="340148at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="64"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="369"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="369"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="408" mass="45865" checksum="7AA04B9B35EDA45F" modified="2005-04-12" version="1">MRHQRRLSYSKKGEREQFKHHLLPYPGKATRTTHGKKCESYPEFLFCIPIKPASNILGCELDTFVRLISIMSICIWLSLLVFEGSYLFTEVIGTQTVLFVAIIMVLGLLLISFGIFCGVLGYIGCTISNSRCVYFFFIQLNFQLIANVYALIASVIRGYITYSCAYLLCIISICFFLYPSWSLYVHIKINGIPPNAHKHYGLLNDVLSKVEQKNERRSNLEESESLVENGCSSISNGPGMTTSIQINSQIFQKKEQNRITMLKKQSTKNSGEIIHKNNSEDNIEKLSHIAVKFSDENDSSGTCTEKPTGQVLNIQTLDSLDSSQQSSNKNSFTQPLISSDVSYKLRNEAKIFLNWSKPTISVNRNIATSPNANCSNGNSGTPPQYSKLQVSNQNNRPKFTRSDVYNGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU09</accession>
    <name>Q5CU09_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Membrane</location>
            <topology evidence="4">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the SNAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626310.1">
        <property type="nucleotide sequence ID" value="XM_626310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU09"/>
    <dbReference type="FunCoup" id="Q5CU09">
        <property type="interactions" value="333"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU09"/>
    <dbReference type="GeneID" id="3373653"/>
    <dbReference type="KEGG" id="cpv:cgd2_760"/>
    <dbReference type="InParanoid" id="Q5CU09"/>
    <dbReference type="OMA" id="WSVKEYL"/>
    <dbReference type="OrthoDB" id="9984275at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005483">
        <property type="term" value="F:soluble NSF attachment protein activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15832">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000744">
        <property type="entry name" value="NSF_attach"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768:SF8">
        <property type="entry name" value="ALPHA-SOLUBLE NSF ATTACHMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13768">
        <property type="entry name" value="SOLUBLE NSF ATTACHMENT PROTEIN SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14938">
        <property type="entry name" value="SNAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00448">
        <property type="entry name" value="NSFATTACHMNT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU367013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="338" mass="38835" checksum="580469321B1E674A" modified="2005-04-12" version="1" fragment="single">FDMEEAQELFRKAEKAGKGSTGFFSSLLSGGPDYDEAIQLYSEAGNKFKILKAWMDGCECFSRAAELSLKQNDLVTASNYYTECGNIMKRSDLQKAIPYFLKAVELYNKNGRFSQSGKLYKNIAESLESDFQYVECCEFYKKAADMFDMDEYSKTAYSSCILKYADNFSLSINDEYSNHSISNTEKTALGNNSLLEAVEIYEKEAKKALSNSLIKYNAKEYLFKAFLIILSLEDNVDAQIKWEKYSSIDQSFCTSPQGKLCRSILDIMERRQNSVGEENDDLDKNRFVEEFTSLIEEYNNIYPVDDWKVHFLSIIKKNLSRIAMNLIEKAENNEFDLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU10</accession>
    <name>Q5CU10_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Bub3'bub3-like protein with WD40 repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_750</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626309.1">
        <property type="nucleotide sequence ID" value="XM_626309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU10"/>
    <dbReference type="STRING" id="353152.Q5CU10"/>
    <dbReference type="GeneID" id="3373376"/>
    <dbReference type="KEGG" id="cpv:cgd2_750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_750"/>
    <dbReference type="InParanoid" id="Q5CU10"/>
    <dbReference type="OMA" id="WDSTLHI"/>
    <dbReference type="OrthoDB" id="10262475at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="306"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="422" mass="47241" checksum="3E77FD7998BDF702" modified="2005-04-12" version="1">MQSYFLSECPEEPIGSIDVIKSYNRQEILGQNEGCLLALTCWNKSVKFYDPQIPYGASLNDNFKYNPSNESIERSDELQNTSTSVQNTKYISTGKCLQSLQCEYIYLACKFKNDSTIFFGGFNEAVDVINLQDSLYSPRKLVGHLAPVRCLSLLENSSILASGDWNGEVLLTCVNEGSFGSQISKISLPGKVFCMDYSYNEEWLLVGDSLKNMNLINLKKLSSGIEATTPTEVVPNFMKYQLRNICANKHKDVFATSSIEGRVQITSVEKALKGEVNSKESPKDNYAFKCHRTKDNSMMTETIYPVNSVCFHPQFANVLATGGSDASVFLWDTSAKKRLWRNSNFQLVDSDKNLIRVCNESISSLKFHPTLPYLISSCCDTFDQSCRLSSETRDQANDGSNSIPVQRSSIIFHSVHGVKPLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU44</accession>
    <name>Q5CU44_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase'insulinase like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd3_4270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626970.1">
        <property type="nucleotide sequence ID" value="XM_626970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU44"/>
    <dbReference type="STRING" id="353152.Q5CU44"/>
    <dbReference type="GeneID" id="3374060"/>
    <dbReference type="KEGG" id="cpv:cgd3_4270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4270"/>
    <dbReference type="InParanoid" id="Q5CU44"/>
    <dbReference type="OMA" id="LACWEQV"/>
    <dbReference type="OrthoDB" id="342973at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254520" evidence="8">
        <location>
            <begin position="21"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="88"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="248"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="11">
        <location>
            <begin position="439"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="12">
        <location>
            <begin position="981"/>
            <end position="1069"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1176" mass="137284" checksum="37A79430B9E3C5D5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUC2</accession>
    <name>Q5CUC2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_3410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626892.1">
        <property type="nucleotide sequence ID" value="XM_626892.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3374122"/>
    <dbReference type="KEGG" id="cpv:cgd3_3410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3410"/>
    <dbReference type="InParanoid" id="Q5CUC2"/>
    <dbReference type="OMA" id="CIIRIAN"/>
    <dbReference type="OrthoDB" id="340359at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38566:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_18, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38566">
        <property type="entry name" value="RNA_LIG_T4_1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1536" mass="176352" checksum="89CF4E7D622C1710" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUD0</accession>
    <name>Q5CUD0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_3330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626884.1">
        <property type="nucleotide sequence ID" value="XM_626884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUD0"/>
    <dbReference type="GeneID" id="3373866"/>
    <dbReference type="KEGG" id="cpv:cgd3_3330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3330"/>
    <dbReference type="InParanoid" id="Q5CUD0"/>
    <dbReference type="OMA" id="SNCKNER"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="757"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="762"/>
            <end position="787"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="963" mass="107804" checksum="8CBA8EB9E24ECBA7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUD2</accession>
    <name>Q5CUD2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein with several coiled coil regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_3310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626882.1">
        <property type="nucleotide sequence ID" value="XM_626882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUD2"/>
    <dbReference type="STRING" id="353152.Q5CUD2"/>
    <dbReference type="GeneID" id="3373867"/>
    <dbReference type="KEGG" id="cpv:cgd3_3310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3310"/>
    <dbReference type="InParanoid" id="Q5CUD2"/>
    <dbReference type="OrthoDB" id="71227at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="257"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="421"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="257"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="719" mass="84242" checksum="A909013CFB79C2F3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUD8</accession>
    <name>Q5CUD8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CCAAT-binding factor (CBF)/MAK21 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_3250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89013.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626876.1">
        <property type="nucleotide sequence ID" value="XM_626876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUD8"/>
    <dbReference type="STRING" id="353152.Q5CUD8"/>
    <dbReference type="GeneID" id="3373873"/>
    <dbReference type="KEGG" id="cpv:cgd3_3250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3250"/>
    <dbReference type="InParanoid" id="Q5CUD8"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027193">
        <property type="entry name" value="Noc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12455:SF0">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="2">
        <location>
            <begin position="96"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89013.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="397" mass="45774" checksum="811FDC3373EEB366" modified="2005-04-12" version="1">MFGSDFDGDLDKIAKFDKNYRVIYQKLWLKYINIVIMNYNDENRNIPLPILKDALEYVSEFVIPIISNPLELADIFKNCFDGISNKINPMDKLAISVISLNGLFYLIVNNRLNEGFNLNNESEENISSGYYRRLYELLCPPVFSLKVRAKFLKLLSISLFSPLIPMTVLSCFIKKLIRISLFTSMNNTVWIIALVNSIIKKHRNILFPVLSLNESDEIYEYVNTILKNTQGELWSYDKGINSYKNDQFFNPYKPSVNLSEGQKIDTADSLNNNCEMGTYLSSNFGLWELYIHNKSVVPVIRHLSNTLTMNASNAKVNRHLHNLNYEDLIGLSTEEILAHEITSPNGILHNYSACFIKDKKNIVPYNYIEYSKLSSTNLFQNSNKFFTDSDVELFSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUI2</accession>
    <name>Q5CUI2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">T1Dc domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626832.1">
        <property type="nucleotide sequence ID" value="XM_626832.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUI2"/>
    <dbReference type="STRING" id="353152.Q5CUI2"/>
    <dbReference type="GeneID" id="3373964"/>
    <dbReference type="KEGG" id="cpv:cgd3_2740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2740"/>
    <dbReference type="InParanoid" id="Q5CUI2"/>
    <dbReference type="OMA" id="IRTIDDC"/>
    <dbReference type="OrthoDB" id="289228at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF108">
        <property type="entry name" value="RE10231P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="1">
        <location>
            <begin position="284"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="542" mass="61772" checksum="814E41B0E8812A06" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUJ9</accession>
    <name>Q5CUJ9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd3_2540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626815.1">
        <property type="nucleotide sequence ID" value="XM_626815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUJ9"/>
    <dbReference type="FunCoup" id="Q5CUJ9">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUJ9"/>
    <dbReference type="GeneID" id="3373906"/>
    <dbReference type="KEGG" id="cpv:cgd3_2540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2540"/>
    <dbReference type="InParanoid" id="Q5CUJ9"/>
    <dbReference type="OMA" id="DSNRCAI"/>
    <dbReference type="OrthoDB" id="4025405at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000078">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000044">
        <property type="entry name" value="Histone H3.3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="44"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="135" mass="15382" checksum="FA3BD96A8371C374" modified="2005-04-12" version="1">MARTKQTARKSTGGKAPRKQLASKGARKSAPVTGGVKKPRRYRPGTVALREIRRFQRSTELLIRKLPFQRLVREIAQDFKTDLRFQSQAVMALQEAAEAYLVGLFEDTNLCAIHAHRVTIMPKDIQLARRIRGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUK0</accession>
    <name>Q5CUK0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_2530</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626814.1">
        <property type="nucleotide sequence ID" value="XM_626814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUK0"/>
    <dbReference type="FunCoup" id="Q5CUK0">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUK0"/>
    <dbReference type="GeneID" id="3373907"/>
    <dbReference type="KEGG" id="cpv:cgd3_2530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2530"/>
    <dbReference type="InParanoid" id="Q5CUK0"/>
    <dbReference type="OMA" id="KQHLFRH"/>
    <dbReference type="OrthoDB" id="429533at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03763">
        <property type="entry name" value="proteasome_beta_type_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF4">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 9 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="8">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="279" mass="30406" checksum="2A486EC06C4B6215" modified="2005-04-12" version="1">MNAYLNAYFSEKSTNGFLFENNIATAPCLSDSTELKTVKTGTTIVGVACNDCVVLGADTRATNGPIVADKDCEKIHRLSDNIFAAGAGTAADLDHVTSLIEGNLELQKLQMNRKPRVAHAVSMLSDHLYKYQGYIGAHLIVAGSDSTGNFVFQVSANGCIMQLPFTSMGSGSLCARSILEARYRDGLTESECVELVSDAIRAGIYNDLYSGSNVNILIIKNNYVKHFRHFDTKASERIYRQPKPISFPVGTTPIIAEKTEDLSSFVVEVSEVQIDENMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUM8</accession>
    <name>Q5CUM8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Type I fatty acid synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd3_2180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="12">Iowa type II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626786.1">
        <property type="nucleotide sequence ID" value="XM_626786.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUM8"/>
    <dbReference type="GeneID" id="3374038"/>
    <dbReference type="KEGG" id="cpv:cgd3_2180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2180"/>
    <dbReference type="InParanoid" id="Q5CUM8"/>
    <dbReference type="OMA" id="MYPDPAA"/>
    <dbReference type="OrthoDB" id="16262at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004315">
        <property type="term" value="F:3-oxoacyl-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004312">
        <property type="term" value="F:fatty acid synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031177">
        <property type="term" value="F:phosphopantetheine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05195">
        <property type="entry name" value="enoyl_red"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00833">
        <property type="entry name" value="PKS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="CDD" id="cd05235">
        <property type="entry name" value="SDR_e1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.47.10:FF:000019">
        <property type="entry name" value="Polyketide synthase type I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.47.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.10">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.250">
        <property type="entry name" value="Malonyl-CoA ACP transacylase, ACP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.366.10">
        <property type="entry name" value="Malonyl-Coenzyme A Acyl Carrier Protein, domain 2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.110">
        <property type="entry name" value="Polyketide synthase dehydratase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001227">
        <property type="entry name" value="Ac_transferase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036736">
        <property type="entry name" value="ACP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014043">
        <property type="entry name" value="Acyl_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013120">
        <property type="entry name" value="FAR_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018201">
        <property type="entry name" value="Ketoacyl_synth_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014031">
        <property type="entry name" value="Ketoacyl_synth_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014030">
        <property type="entry name" value="Ketoacyl_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057326">
        <property type="entry name" value="KR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016036">
        <property type="entry name" value="Malonyl_transacylase_ACP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020841">
        <property type="entry name" value="PKS_Beta-ketoAc_synthase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042104">
        <property type="entry name" value="PKS_dehydratase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049551">
        <property type="entry name" value="PKS_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013968">
        <property type="entry name" value="PKS_KR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049900">
        <property type="entry name" value="PKS_mFAS_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050091">
        <property type="entry name" value="PKS_NRPS_Biosynth_Enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020806">
        <property type="entry name" value="PKS_PP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009081">
        <property type="entry name" value="PP-bd_ACP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006162">
        <property type="entry name" value="Ppantetheine_attach_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010080">
        <property type="entry name" value="Thioester_reductase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016039">
        <property type="entry name" value="Thiolase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775">
        <property type="entry name" value="FATTY ACID SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43775:SF37">
        <property type="entry name" value="SI:DKEY-61P9.11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00698">
        <property type="entry name" value="Acyl_transf_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00109">
        <property type="entry name" value="ketoacyl-synt"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02801">
        <property type="entry name" value="Ketoacyl-synt_C"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08659">
        <property type="entry name" value="KR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07993">
        <property type="entry name" value="NAD_binding_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00550">
        <property type="entry name" value="PP-binding"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14765">
        <property type="entry name" value="PS-DH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00827">
        <property type="entry name" value="PKS_AT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00822">
        <property type="entry name" value="PKS_KR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00825">
        <property type="entry name" value="PKS_KS"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00823">
        <property type="entry name" value="PKS_PP"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM01294">
        <property type="entry name" value="PKS_PP_betabranch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47336">
        <property type="entry name" value="ACP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55048">
        <property type="entry name" value="Probable ACP-binding domain of malonyl-CoA ACP transacylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53901">
        <property type="entry name" value="Thiolase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50075">
        <property type="entry name" value="CARRIER"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00606">
        <property type="entry name" value="KS3_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52004">
        <property type="entry name" value="KS3_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00012">
        <property type="entry name" value="PHOSPHOPANTETHEINE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52019">
        <property type="entry name" value="PKS_MFAS_DH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="1" id="KW-0596">Phosphopantetheine</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="788"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="884"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="1710"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="2921"/>
            <end position="2996"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="3023"/>
            <end position="3465"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="3863"/>
            <end position="4217"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="5157"/>
            <end position="5231"/>
        </location>
    </feature>
    <feature type="domain" description="Ketosynthase family 3 (KS3)" evidence="10">
        <location>
            <begin position="5251"/>
            <end position="5691"/>
        </location>
    </feature>
    <feature type="domain" description="PKS/mFAS DH" evidence="11">
        <location>
            <begin position="6071"/>
            <end position="6419"/>
        </location>
    </feature>
    <feature type="domain" description="Carrier" evidence="9">
        <location>
            <begin position="7299"/>
            <end position="7375"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1710"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="1889"/>
            <end position="2040"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="3863"/>
            <end position="4013"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="4038"/>
            <end position="4217"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal hotdog fold" evidence="7">
        <location>
            <begin position="6071"/>
            <end position="6222"/>
        </location>
    </feature>
    <feature type="region of interest" description="C-terminal hotdog fold" evidence="7">
        <location>
            <begin position="6244"/>
            <end position="6419"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="6450"/>
            <end position="6470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="6454"/>
            <end position="6465"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="1740"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="1954"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="3897"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="4119"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor; for dehydratase activity" evidence="7">
        <location>
            <position position="6106"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor; for dehydratase activity" evidence="7">
        <location>
            <position position="6321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="8243" mass="920785" checksum="0B9B505C9F2FA4A7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUU7</accession>
    <name>Q5CUU7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein kish</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_1420</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 9">Involved in the early part of the secretory pathway.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the KISH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626717.1">
        <property type="nucleotide sequence ID" value="XM_626717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUU7"/>
    <dbReference type="FunCoup" id="Q5CUU7">
        <property type="interactions" value="240"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUU7"/>
    <dbReference type="GeneID" id="3373834"/>
    <dbReference type="KEGG" id="cpv:cgd3_1420"/>
    <dbReference type="InParanoid" id="Q5CUU7"/>
    <dbReference type="OMA" id="KVGFQGT"/>
    <dbReference type="OrthoDB" id="10034655at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051523">
        <property type="entry name" value="KISH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009653">
        <property type="entry name" value="Ksh1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13229">
        <property type="entry name" value="PROTEIN KISH-A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06842">
        <property type="entry name" value="DUF1242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU910717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="76" mass="8401" checksum="1BEEF66DB1287258" modified="2005-04-12" version="1" fragment="single">FSIKMSALFNFQSMIVVVLLSICTCSYLRPKIPGLIDNKKSGFLGILGKMAVIGDRLSPYVSFACILMAGMTLFYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUW0</accession>
    <name>Q5CUW0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">14-3-3 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_1290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="journal article" date="2011" name="PLoS ONE" volume="6" first="e14827" last="e14827">
            <title>Characterization of 14-3-3 proteins from Cryptosporidium parvum.</title>
            <authorList>
                <person name="Brokx S.J."/>
                <person name="Wernimont A.K."/>
                <person name="Dong A."/>
                <person name="Wasney G.A."/>
                <person name="Lin Y.H."/>
                <person name="Lew J."/>
                <person name="Vedadi M."/>
                <person name="Lee W.H."/>
                <person name="Hui R."/>
            </authorList>
            <dbReference type="PubMed" id="21853016"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0014827"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.52 ANGSTROMS) OF 1-259</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626704.1">
        <property type="nucleotide sequence ID" value="XM_626704.1"/>
    </dbReference>
    <dbReference type="PDB" id="2NPM">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.52 A"/>
        <property type="chains" value="A/B=1-259"/>
    </dbReference>
    <dbReference type="PDBsum" id="2NPM"/>
    <dbReference type="AlphaFoldDB" id="Q5CUW0"/>
    <dbReference type="SMR" id="Q5CUW0"/>
    <dbReference type="FunCoup" id="Q5CUW0">
        <property type="interactions" value="211"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUW0"/>
    <dbReference type="GeneID" id="3373836"/>
    <dbReference type="KEGG" id="cpv:cgd3_1290"/>
    <dbReference type="InParanoid" id="Q5CUW0"/>
    <dbReference type="OMA" id="KGCQLAR"/>
    <dbReference type="OrthoDB" id="10260625at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CUW0"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd08774">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.190.20:FF:000001">
        <property type="entry name" value="14-3-3 gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023409">
        <property type="entry name" value="14-3-3_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00796">
        <property type="entry name" value="1433_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00797">
        <property type="entry name" value="1433_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="4">
        <location>
            <begin position="27"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="2NPM"/>
        </source>
    </evidence>
    <sequence length="273" mass="30900" checksum="4BBDF1E9696F3767" modified="2005-04-12" version="1" fragment="single">ILRTQHTIRDSELNIKNSKMSDSVNARESNVYMAKLAEQAERYDEMAKYMKDVVEARQESEELTVEERNLLSVAYKNAVGSRRSSWRIISSVEQKEHSRNAEDASKMCGKYRSKVEAELTDICNDILTMLDKHLIPTATSPDSKVFYFKMKGDYHRYISEFSTGDSKQSSAEDALKAYKDATVVAKDLEPTHPIRLGLALNFSVFHYEILNEPRAAIDMAKEAFEMAIEQLDKLSEDCYKDSTLIMQLLRDNLTLWTADLGASGEAEGAPEAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUZ9</accession>
    <name>Q5CUZ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L35</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL29 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89183.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626665.1">
        <property type="nucleotide sequence ID" value="XM_626665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUZ9"/>
    <dbReference type="FunCoup" id="Q5CUZ9">
        <property type="interactions" value="377"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUZ9"/>
    <dbReference type="GeneID" id="3374129"/>
    <dbReference type="KEGG" id="cpv:cgd3_830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_830"/>
    <dbReference type="InParanoid" id="Q5CUZ9"/>
    <dbReference type="OMA" id="VMNQKAR"/>
    <dbReference type="OrthoDB" id="528635at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00427">
        <property type="entry name" value="Ribosomal_L29_HIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.310:FF:000002">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="6.10.250.3450:FF:000001">
        <property type="entry name" value="60S ribosomal protein L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00374">
        <property type="entry name" value="Ribosomal_uL29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001854">
        <property type="entry name" value="Ribosomal_uL29"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045059">
        <property type="entry name" value="Ribosomal_uL29_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036049">
        <property type="entry name" value="Ribosomal_uL29_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00012">
        <property type="entry name" value="L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45722:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL29-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00831">
        <property type="entry name" value="Ribosomal_L29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46561">
        <property type="entry name" value="Ribosomal protein L29 (L29p)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89183.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="126" mass="14258" checksum="F552165E9BD7F983" modified="2005-04-12" version="1">MNKNSGLQIKQLISLSEEELTVKIDELKKELASLRVIQSTGTAPNKLSRINVVRKGIARILTILSQRNIKSLREKHAGSKFMPLDLRKKLTRAKRRALTPQQAKKMTVKASKKALNFPKRKFAIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV32</accession>
    <name>Q5CV32_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Amino acid transporter transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626632.1">
        <property type="nucleotide sequence ID" value="XM_626632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV32"/>
    <dbReference type="GeneID" id="3373804"/>
    <dbReference type="KEGG" id="cpv:cgd3_470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_470"/>
    <dbReference type="InParanoid" id="Q5CV32"/>
    <dbReference type="OMA" id="IARSCTQ"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="14"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="39"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="203"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="253"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="286"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="443"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="469"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="500"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="176"/>
            <end position="517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="534" mass="59380" checksum="36653B7C9600C222" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV84</accession>
    <name>Q5CV84_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Articulin family protein, Pfs77 protein-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_5030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627385.1">
        <property type="nucleotide sequence ID" value="XM_627385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV84"/>
    <dbReference type="STRING" id="353152.Q5CV84"/>
    <dbReference type="GeneID" id="3374206"/>
    <dbReference type="KEGG" id="cpv:cgd8_5030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5030"/>
    <dbReference type="InParanoid" id="Q5CV84"/>
    <dbReference type="OMA" id="DIPVIKY"/>
    <dbReference type="OrthoDB" id="390934at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022086">
        <property type="entry name" value="IMCp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12314">
        <property type="entry name" value="IMCp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="324" mass="36760" checksum="0BF11BCE35D96A6D" modified="2005-04-12" version="1">MQQPQQPNDMFHTSVGDGVTATWVDPAQMGQVNNNCFPNQAHPSSGYYRLEVDQAPLITVPVVQEIQRRDKIIEVPQTIIKDKILPKIYHQEVIHEVPKLEVEVQEKEVEVPNVTVVEKVVDLEHIVGFNPKYVPTWEVREVPKLVPKFVGEQKVLYIEISQIQYVDKVTEKEVVVDVVDKVVPKVVEIEEPIEVIRYKWKEVYDDIPVVKYVPKFDVEVVCPAPVIVPYVQPEIKDLPPVKVTVGPDGRETNMAQDYNIPNNVVSSPNSIPNMNANLAQINDINSSPFPLPEGSQPVEPRMPQFMKGNMPVNVRVMPPHPNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV94</accession>
    <name>Q5CV94_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNAj protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627375.1">
        <property type="nucleotide sequence ID" value="XM_627375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV94"/>
    <dbReference type="STRING" id="353152.Q5CV94"/>
    <dbReference type="GeneID" id="3374662"/>
    <dbReference type="KEGG" id="cpv:cgd8_4930"/>
    <dbReference type="InParanoid" id="Q5CV94"/>
    <dbReference type="OMA" id="ISITNYK"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF10">
        <property type="entry name" value="MRJ, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="168"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="627" mass="73663" checksum="099535E453218BA9" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVD8</accession>
    <name>Q5CVD8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Translation initiation factor if-2 betam beta subunit ZnR</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_4430</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627331.1">
        <property type="nucleotide sequence ID" value="XM_627331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVD8"/>
    <dbReference type="FunCoup" id="Q5CVD8">
        <property type="interactions" value="224"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVD8"/>
    <dbReference type="GeneID" id="3374536"/>
    <dbReference type="KEGG" id="cpv:cgd8_4430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4430"/>
    <dbReference type="InParanoid" id="Q5CVD8"/>
    <dbReference type="OMA" id="WPDYTYE"/>
    <dbReference type="OrthoDB" id="10255414at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Translation initiation factor IF2/IF5" evidence="4">
        <location>
            <begin position="79"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="214" mass="24274" checksum="EC0EA7CD51D1D136" modified="2005-04-12" version="1">MSEKELIEGVQKMDMGYDFGEKKKKKKSKEHKTGVSEVESSYVDGSGQLFVKGAIYPYEELLERVRRLILEHNPDLWGAKRYTLKPPQVVRVGSKKVAWINFQEICNIMQRNADHVFQFVLSELGTEGSIAGDGQLVLKGKYGPKHIEVLLRKYIMEYVACSMCKSPNTRLERDNRTRLYTIVCAACGANRSVQNIKTGFHAVSRADRKKAKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVH7</accession>
    <name>Q5CVH7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Histidine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="2">6.1.1.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd8_4010</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(His) + L-histidine + ATP = L-histidyl-tRNA(His) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17313"/>
            <dbReference type="Rhea" id="RHEA-COMP:9665"/>
            <dbReference type="Rhea" id="RHEA-COMP:9689"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57595"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78527"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.21"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.21" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627292.1">
        <property type="nucleotide sequence ID" value="XM_627292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVH7"/>
    <dbReference type="FunCoup" id="Q5CVH7">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVH7"/>
    <dbReference type="GeneID" id="3374594"/>
    <dbReference type="KEGG" id="cpv:cgd8_4010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4010"/>
    <dbReference type="InParanoid" id="Q5CVH7"/>
    <dbReference type="OMA" id="HESRNIH"/>
    <dbReference type="OrthoDB" id="1906957at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004821">
        <property type="term" value="F:histidine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006427">
        <property type="term" value="P:histidyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032543">
        <property type="term" value="P:mitochondrial translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00773">
        <property type="entry name" value="HisRS-like_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000061">
        <property type="entry name" value="Histidine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000012">
        <property type="entry name" value="Histidine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00127">
        <property type="entry name" value="His_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015807">
        <property type="entry name" value="His-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041715">
        <property type="entry name" value="HisRS-like_core"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00442">
        <property type="entry name" value="hisS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476:SF7">
        <property type="entry name" value="HISTIDINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11476">
        <property type="entry name" value="HISTIDYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13393">
        <property type="entry name" value="tRNA-synt_His"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="510"/>
            <end position="837"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015302"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047639"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="977" mass="110135" checksum="0F0EA0599D2B9715" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVK0</accession>
    <name>Q5CVK0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNAJ like chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_3770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627269.1">
        <property type="nucleotide sequence ID" value="XM_627269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVK0"/>
    <dbReference type="FunCoup" id="Q5CVK0">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVK0"/>
    <dbReference type="GeneID" id="3374609"/>
    <dbReference type="KEGG" id="cpv:cgd8_3770"/>
    <dbReference type="InParanoid" id="Q5CVK0"/>
    <dbReference type="OMA" id="SSKYVYH"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009408">
        <property type="term" value="P:response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000003">
        <property type="entry name" value="DnaJ subfamily A member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000068">
        <property type="entry name" value="HSP40, subfamily A, putative"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01152">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="DnaJ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="40"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="155"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="5">
        <location>
            <begin position="155"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="389"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="403"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="434" mass="48171" checksum="CCD2DA69208DAFB4" modified="2005-04-12" version="1" fragment="single">RVFKSVYIVKMFFSSMPFDMGGGFDGRMGGRMSREVDNKKLYEILEVSQEATLSEIKKAYRRLAIKHHPDKGGDQEKFKEVSRAYEVLSDPEKRKIYDEYGEEGLEGGGGGADPVDLFDVIFGGGRRAGSRGGGKRRGEDLVTHLKVTLEQIYNGAVRKMAINKDTICADCEGVGGPKDAIQYCELCQGQGVRVQIRQIGPMVQQTQSPCNPCKGTGKTIPVTKQCKKCSGSGSVKERKVLEVNIDKGIPNHHKVTFHGEADEKQGEIPGDVVFVLDEQEHSVFKRKGGDLFIEKDITLVEALTGFKFIITHLDGRKLLVKSNPGDITKPSDIKCVNNEGMPTYKNPFVKGHLFVIINIIFPDKLDSKTQDLVKTLLPAPKALNVDEDDPSIEIHYTSNTKPSEVKDRIQKEAYQEDDEDGHHGGAERVSCRQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVQ0</accession>
    <name>Q5CVQ0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_3230</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627219.1">
        <property type="nucleotide sequence ID" value="XM_627219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVQ0"/>
    <dbReference type="STRING" id="353152.Q5CVQ0"/>
    <dbReference type="GeneID" id="3374246"/>
    <dbReference type="KEGG" id="cpv:cgd8_3230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3230"/>
    <dbReference type="InParanoid" id="Q5CVQ0"/>
    <dbReference type="OMA" id="ENTSNCI"/>
    <dbReference type="OrthoDB" id="342635at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="420"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="260"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="374"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="727"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="271"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="379"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="490"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="727"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="739"/>
            <end position="749"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="819" mass="90125" checksum="85BA8363DA052598" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVU9</accession>
    <name>Q5CVU9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phenol 2-monooxygenase like FAD dependent oxidoreductase of plant origin in apicomplexans</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_2700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627170.1">
        <property type="nucleotide sequence ID" value="XM_627170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVU9"/>
    <dbReference type="STRING" id="353152.Q5CVU9"/>
    <dbReference type="GeneID" id="3374395"/>
    <dbReference type="KEGG" id="cpv:cgd8_2700"/>
    <dbReference type="InParanoid" id="Q5CVU9"/>
    <dbReference type="OMA" id="ADLSEYW"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016709">
        <property type="term" value="F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002938">
        <property type="entry name" value="FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050641">
        <property type="entry name" value="RIFMO-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004:SF6">
        <property type="entry name" value="FAD_NAD(P)-BINDING OXIDOREDUCTASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43004">
        <property type="entry name" value="TRK SYSTEM POTASSIUM UPTAKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01494">
        <property type="entry name" value="FAD_binding_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00420">
        <property type="entry name" value="RNGMNOXGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0274">FAD</keyword>
    <keyword evidence="1" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0503">Monooxygenase</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD-binding" evidence="3">
        <location>
            <begin position="13"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="489" mass="56573" checksum="F0A525E3498F6BFA" modified="2005-04-12" version="1" fragment="single">FWRLLINMGVIKRTQVLIVGMGPVGMTLSNLLNLYKVDNIIVDKLTQFSPIPKAHYISNRSMEIFRFCNNLDQEIYRLQQPLEFWRRITYLTYFNNCKFGILGTKDEFSNYKTINGYYLDLDSQSGVANYDQSKLNNLLYKNLKQCKYSQIMLGTSWKGYEFVSKSGKEKVISKLEKSNSNLEFTIESDFLVGADGAKSQVRKALNKNFKGHESLQKLLNINFISKDLAKVCLELKQEIIDECNNIKLVPTTSMLYFILNPSLIGVMVLHDISQGNFVIHIPLVGSSSEKFDLDFFKHIFPSLISQVCKKNINLEVKSIETWNMSAQVLDSFVDEKTNRIVLIGDSAHRLPPSGGFGMNLGIQDSLNLAWRLAFVLKNKYEEDIKKQLNEFNMERIQHAQYACNNSIRNFYRSLFIPKAIGLDWKIISSMQKLISNADKYIPNKILEEKPVMDYIYKLGMFRFSKILRNENKMEKIKMLIQVSLVLQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW26</accession>
    <name>Q5CW26_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ELMO domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627093.1">
        <property type="nucleotide sequence ID" value="XM_627093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW26"/>
    <dbReference type="GeneID" id="3374465"/>
    <dbReference type="KEGG" id="cpv:cgd8_1890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1890"/>
    <dbReference type="InParanoid" id="Q5CW26"/>
    <dbReference type="OrthoDB" id="67155at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006816">
        <property type="entry name" value="ELMO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050868">
        <property type="entry name" value="ELMO_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771">
        <property type="entry name" value="ENGULFMENT AND CELL MOTILITY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12771:SF51">
        <property type="entry name" value="LD01482P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04727">
        <property type="entry name" value="ELMO_CED12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51335">
        <property type="entry name" value="ELMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELMO" evidence="1">
        <location>
            <begin position="348"/>
            <end position="502"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="516" mass="61032" checksum="690E4705D7E67AF3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWA6</accession>
    <name>Q5CWA6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">H/ACA ribonucleoprotein complex non-core subunit NAF1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd8_1060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627013.1">
        <property type="nucleotide sequence ID" value="XM_627013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWA6"/>
    <dbReference type="STRING" id="353152.Q5CWA6"/>
    <dbReference type="GeneID" id="3374635"/>
    <dbReference type="KEGG" id="cpv:cgd8_1060"/>
    <dbReference type="InParanoid" id="Q5CWA6"/>
    <dbReference type="OMA" id="SECENEM"/>
    <dbReference type="OrthoDB" id="21550at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000493">
        <property type="term" value="P:box H/ACA snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040309">
        <property type="entry name" value="Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633">
        <property type="entry name" value="H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31633:SF1">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="323"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="439"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="329"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="354"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="382"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="701" mass="78879" checksum="F562B9416ED7878B" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWL5</accession>
    <name>Q5CWL5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA-directed RNA polymerase III subunit RPC6</fullName>
            <shortName evidence="6">RNA polymerase III subunit C6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_4580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627789.1">
        <property type="nucleotide sequence ID" value="XM_627789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWL5"/>
    <dbReference type="FunCoup" id="Q5CWL5">
        <property type="interactions" value="267"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWL5"/>
    <dbReference type="GeneID" id="3375794"/>
    <dbReference type="KEGG" id="cpv:cgd6_4580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4580"/>
    <dbReference type="InParanoid" id="Q5CWL5"/>
    <dbReference type="OMA" id="FSCDIFN"/>
    <dbReference type="OrthoDB" id="613763at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000116">
        <property type="entry name" value="DNA-directed RNA polymerase III subunit RPC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007832">
        <property type="entry name" value="RNA_pol_Rpc34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016049">
        <property type="entry name" value="RNA_pol_Rpc34-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12780">
        <property type="entry name" value="RNA POLYMERASE III DNA DIRECTED , 39KD SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05158">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028763">
        <property type="entry name" value="RNA_pol_Rpc34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR028763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="319" mass="35767" checksum="277229AB7457479D" modified="2007-04-03" version="1">MSQPGGAGGSKTQITAAILQEAYIHGCQNNNELSPDSLKSLGWDNSVIVRVLNIFTEKRLCSVKKNRPSGLLSSVNNKVVFQLRTEEVACKLNKLSNEEYLVFCSIEDAGNQGIWTADIRKNTGLQTHVVQRAVKVLCNDWNLIRPVKSIHVKNRKVYILASLEPSKELSGGTFYENGEFDMAFVDSIKEKIISFIDSKRKCTLQEILEFINYDMNMDSSSARKNISLSDLQSVINMLIVELKIICVKGGNSNSNENFFMCLKWPESLSVTPEAEDVPCLACPVFETCSWSFESQILPCPQLCKYIDYSLKNCKPLLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWZ0</accession>
    <name>Q5CWZ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S15</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_3180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627664.1">
        <property type="nucleotide sequence ID" value="XM_627664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWZ0"/>
    <dbReference type="FunCoup" id="Q5CWZ0">
        <property type="interactions" value="286"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWZ0"/>
    <dbReference type="GeneID" id="3375893"/>
    <dbReference type="KEGG" id="cpv:cgd6_3180"/>
    <dbReference type="InParanoid" id="Q5CWZ0"/>
    <dbReference type="OMA" id="KTHCRDM"/>
    <dbReference type="OrthoDB" id="10258210at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.860.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.860.10">
        <property type="entry name" value="30s Ribosomal Protein S19, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00531">
        <property type="entry name" value="Ribosomal_uS19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002222">
        <property type="entry name" value="Ribosomal_uS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020934">
        <property type="entry name" value="Ribosomal_uS19_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005713">
        <property type="entry name" value="Ribosomal_uS19_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023575">
        <property type="entry name" value="Ribosomal_uS19_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003121">
        <property type="entry name" value="PRK04038.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01025">
        <property type="entry name" value="uS19_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880">
        <property type="entry name" value="RIBOSOMAL PROTEIN S19P FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11880:SF2">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00203">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002144">
        <property type="entry name" value="Ribosomal_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00975">
        <property type="entry name" value="RIBOSOMALS19"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54570">
        <property type="entry name" value="Ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00323">
        <property type="entry name" value="RIBOSOMAL_S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="152" mass="17208" checksum="87DB229D01C24A7F" modified="2005-04-12" version="1" fragment="single">TSTREKKMADTEQKKRTFRTYSYRGVDLDKLLTMKLDEVVELLPARKRRKIARGCLNRRTAAFIAKLRKSKAECPMGEKPVAVRTHLRNMVILPEMVGSVAGVYNGKTYVTVEIKPEMIGMYLGEFSITYKPVRHGKPGVGSTSSSRFIPLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX64</accession>
    <name>Q5CX64_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627590.1">
        <property type="nucleotide sequence ID" value="XM_627590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX64"/>
    <dbReference type="GeneID" id="3376181"/>
    <dbReference type="KEGG" id="cpv:cgd6_2330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2330"/>
    <dbReference type="InParanoid" id="Q5CX64"/>
    <dbReference type="OMA" id="SIAIYFE"/>
    <dbReference type="OrthoDB" id="339043at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253936" evidence="1">
        <location>
            <begin position="23"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="302" mass="31842" checksum="B50A8766332A7020" modified="2007-04-03" version="1">MSGARSSIFIACILYFISLVSANGVCILKKGASCLNASYSFIEGGMTPGDAIRVSVVLLPSASLELTNSSFQNIATLRFGVDSCSIESGIASLRAYSLYKNGQYNTGSTISFDLVALEKSLAIFIAGSKVLEIPLLVAAPFMLTSDSNGSAPTLQFLEYSTTETGFCSIASSGSCNNSSLVGMSNGVTKNLTIRAELPSSIPDDYFSFYISTYSNIYKLPVLEVAFTKQEWLATSSGSFVGRGKIPAGINLGSSINFVLVPSSGGSVELKVNEKSLGVVKVDASSIKFIYQSVSQGTMNVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX67</accession>
    <name>Q5CX67_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cut4/Apc1p/TSG24 family protein meiotic check point regulator and 26S proteasome regulatory complex PC-rep repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_2300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89881.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627587.1">
        <property type="nucleotide sequence ID" value="XM_627587.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX67"/>
    <dbReference type="GeneID" id="3376179"/>
    <dbReference type="KEGG" id="cpv:cgd6_2300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2300"/>
    <dbReference type="InParanoid" id="Q5CX67"/>
    <dbReference type="OMA" id="CETRIEC"/>
    <dbReference type="OrthoDB" id="26401at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024990">
        <property type="entry name" value="Apc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827:SF3">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12827">
        <property type="entry name" value="MEIOTIC CHECKPOINT REGULATOR TSG24 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89881.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2006" mass="230945" checksum="345CD1D2FA0551E2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXA9</accession>
    <name>Q5CXA9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_1790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627545.1">
        <property type="nucleotide sequence ID" value="XM_627545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXA9"/>
    <dbReference type="GeneID" id="3376060"/>
    <dbReference type="KEGG" id="cpv:cgd6_1790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1790"/>
    <dbReference type="InParanoid" id="Q5CXA9"/>
    <dbReference type="OMA" id="IHCETIL"/>
    <dbReference type="OrthoDB" id="344183at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="959" mass="109935" checksum="8D477B3FA4365586" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXD3</accession>
    <name>Q5CXD3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative histone mRNA hairpin-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_1540</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89827.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627521.1">
        <property type="nucleotide sequence ID" value="XM_627521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXD3"/>
    <dbReference type="STRING" id="353152.Q5CXD3"/>
    <dbReference type="GeneID" id="3376020"/>
    <dbReference type="KEGG" id="cpv:cgd6_1540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1540"/>
    <dbReference type="InParanoid" id="Q5CXD3"/>
    <dbReference type="OMA" id="CEVHEEN"/>
    <dbReference type="OrthoDB" id="265795at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071204">
        <property type="term" value="C:histone pre-mRNA 3'end processing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071207">
        <property type="term" value="F:histone pre-mRNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1120">
        <property type="entry name" value="Histone RNA hairpin-binding protein RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026502">
        <property type="entry name" value="SLBP1/SLBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029344">
        <property type="entry name" value="SLBP_RNA_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038294">
        <property type="entry name" value="SLBP_RNA_bind_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408:SF0">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15247">
        <property type="entry name" value="SLBP_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Histone RNA hairpin-binding protein RNA-binding" evidence="4">
        <location>
            <begin position="297"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="171"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="243"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="245"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="271"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="333"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89827.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="372" mass="41996" checksum="9A9C0F7C50954C80" modified="2007-04-03" version="1">MTENSTREKTVVSKPGWGAVRWADLSISDASNSWIYTQSDTKNESKSIGLTSLLQKNIKLNDSSSEYQCRKTIKENKEKMPNRGFLTINGAETNIEPKLEISNLPQYLGKVSNENFEAIEKGQNIESQEFRFGEGTFTGGLTDISKSDQAVKCLIQDANLNMPKVFGDLPQILNNHSSTNKKRSKDHTENSEYSENINFNYELQVDEDKICKKIKHSKTSTSATEGPKLGKETNQNAVYERCAQKKTTNQLSTPRRISNSTSKSPKGGTPKTPQISSSGRNNDLSIDGTASSNIDWNKRISSRLFQIAIGKGTRAYQNFLKLKPRKEDREPNDPQTPNAHTRCPQKQFTDQLNQWRKSLHQYDDFDSNILEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXI3</accession>
    <name>Q5CXI3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627471.1">
        <property type="nucleotide sequence ID" value="XM_627471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXI3"/>
    <dbReference type="FunCoup" id="Q5CXI3">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXI3"/>
    <dbReference type="GeneID" id="3376094"/>
    <dbReference type="KEGG" id="cpv:cgd6_990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_990"/>
    <dbReference type="InParanoid" id="Q5CXI3"/>
    <dbReference type="OMA" id="PPKFYDG"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12236">
        <property type="entry name" value="RRM_snRNP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000132">
        <property type="entry name" value="Small nuclear ribonucleoprotein U11/U12 subunit 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034143">
        <property type="entry name" value="snRNP70_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022023">
        <property type="entry name" value="U1snRNP70_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12220">
        <property type="entry name" value="U1snRNP70_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="103"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="197"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="248"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="211"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="281" mass="32785" checksum="D664754A9B3FE1E0" modified="2007-04-03" version="1">MSAVGMSNDLLKFFQARPPLPYVPYPNRRPHKPYQGLADLINENPDLFDKVNTPPEPYISKKMRRETEKLQRIQNYMKDMRKKIESYNPMEENVDNKTFDPYNTLFIARLNYDTTERTLKRELEVYGKILNLRIVKDFQGESRGYAFVEFDNEDSLKEAYKSFNKKSIDGWKVLVDVERGRTVENWLPKRLGGGLGKVRGQEKPESKSFFGGNNSIYNHGSKQGNSNYGNSGFGQTYRQREHRSFRSYGYKGQNDRNSSGGDYNSSRNYGNFGNKKFKYSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXK6</accession>
    <name>Q5CXK6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein with signal peptide plus Thr stretch, possible mucin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89765.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627448.1">
        <property type="nucleotide sequence ID" value="XM_627448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXK6"/>
    <dbReference type="GeneID" id="3376055"/>
    <dbReference type="KEGG" id="cpv:cgd6_710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_710"/>
    <dbReference type="InParanoid" id="Q5CXK6"/>
    <dbReference type="OMA" id="ADTEMIN"/>
    <dbReference type="OrthoDB" id="340859at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35193:SF5">
        <property type="entry name" value="FLOCCULATION PROTEIN FLO11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35193">
        <property type="entry name" value="MUCIN 13A, CELL SURFACE-ASSOCIATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254348" evidence="2">
        <location>
            <begin position="30"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="381"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="388"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89765.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="456" mass="49754" checksum="C754C6E42F8E3BD9" modified="2005-04-12" version="1">MMNISNNIFKVSIFYFVLGLILDFGKVSCIPTGISSSLPQQGSSFQPNSGGNMDSFRNRAQLLSKRVVDPLMNRGDRFSQNVNSLSDSNDQRVESKSFNIPGIPIFGGPRVENRNYLTLPFTRDGHCEKGTIYNITSVDDLIQNSRDLMCILEVGLQPDVIPTGMMYGTMLDLLTDTRDIDMRGIEKFWGGKFAAKGACNRAQDEVVFGYNMVKGKFVVPSIMSLNSLPQHCSLATAEHQDNSQSLILDYMTDKNEVCRAETYTNGPFFGKSEHVNVCAIVKAVGRQPDGGLILLGRGLSYPSLKPNVNPTGLITVLFFAVVTYDNVLPEFISGTPLEPLPSSFDYRLVGIDKDNNSFFPAFGIFNKGDALALNNFTNKFGPPIPVPTTSTSTTSTSSTSTSTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTEVAESARIQNPNSRRLMVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXU3</accession>
    <name>Q5CXU3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine transferase subunit ALG14</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_4930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ALG14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628637.1">
        <property type="nucleotide sequence ID" value="XM_628635.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXU3"/>
    <dbReference type="FunCoup" id="Q5CXU3">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXU3"/>
    <dbReference type="GeneID" id="3372229"/>
    <dbReference type="KEGG" id="cpv:cgd7_4930"/>
    <dbReference type="InParanoid" id="Q5CXU3"/>
    <dbReference type="OMA" id="GTCCIIT"/>
    <dbReference type="OrthoDB" id="5978656at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043541">
        <property type="term" value="C:UDP-N-acetylglucosamine transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004577">
        <property type="term" value="F:N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013969">
        <property type="entry name" value="Oligosacch_biosynth_Alg14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12154:SF4">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE TRANSFERASE SUBUNIT ALG14 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08660">
        <property type="entry name" value="Alg14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="150"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="178" mass="20213" checksum="9DC36C10BB2614D3" modified="2005-04-12" version="1">MYGSIGISIFLFLFALRFYFWVRGRFSFNVGSNEKLERKSNCGEKVKILVVLGSGGHTAELLMLLKDMDLRNKVSLSCVVANTDKFSLEKAINEFSENLKVDKDNVRNYVEFYSIKRSREVGQSYFSSVFTTLASFMDSMRILFQDKYDLIMVNGPGTCIPICFGSLILEVSNSIKRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXZ7</accession>
    <name>Q5CXZ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane associated transporter, 10 transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_4290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628583.1">
        <property type="nucleotide sequence ID" value="XM_628581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXZ7"/>
    <dbReference type="STRING" id="353152.Q5CXZ7"/>
    <dbReference type="GeneID" id="3372164"/>
    <dbReference type="KEGG" id="cpv:cgd7_4290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4290"/>
    <dbReference type="InParanoid" id="Q5CXZ7"/>
    <dbReference type="OMA" id="PSSFWIF"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="218"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="355"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="388"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="421"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="462"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="60"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="521" mass="58360" checksum="016E01BC6437C1A7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY10</accession>
    <name>Q5CY10_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_4140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628570.1">
        <property type="nucleotide sequence ID" value="XM_628568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY10"/>
    <dbReference type="STRING" id="353152.Q5CY10"/>
    <dbReference type="GeneID" id="3372072"/>
    <dbReference type="KEGG" id="cpv:cgd7_4140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4140"/>
    <dbReference type="InParanoid" id="Q5CY10"/>
    <dbReference type="OMA" id="HHWDVKS"/>
    <dbReference type="OrthoDB" id="16717at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045245">
        <property type="entry name" value="Pfs2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836:SF0">
        <property type="entry name" value="PRE-MRNA 3' END PROCESSING PROTEIN WDR33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22836">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="258"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="346"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="408" mass="44755" checksum="DA0EAE4F53C0A492" modified="2005-04-12" version="1">MFTQHDFIPGHDSSEEANLLSHRAVYRPAVDSNSLLVDYLDSGIYNNKKKSCFTLSNSNPLDIRTIGFPFELNKYRSDLICTQQARVSLRARAPCVTIEWYPGGRRLVVGTVGGELTLWNGTYFSFEDLKSVPSGQGAVLALNFSKQDDFIACGDGSGNIVLLTPSLAPIASFRQFLGHVVRDVTISPTGNKVVAAAENVHPIIIDVGSQKIESSLTSRGYDITCAQWHPIKGLIATGSQTYQLHLWDPRTANAIGTIFGHRHTVVRIKWSSSGQMLASSGKDGALKIWDIRQLSKPITTYRTKCDAVSISWHPEVESLMAVGFFDGDIAYYNIDVNFGNPLGLIPSAHQGAVWGVAWHPLGHLVVSSGQDSRLKIWSRNLCGSPGTINEHEILPQLSLPRQNPTNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY43</accession>
    <name>Q5CY43_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Apicomplexan P36 family of proteins, appears to be a divergent HAD family phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3740</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628537.1">
        <property type="nucleotide sequence ID" value="XM_628535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY43"/>
    <dbReference type="GeneID" id="3372123"/>
    <dbReference type="KEGG" id="cpv:cgd7_3740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3740"/>
    <dbReference type="InParanoid" id="Q5CY43"/>
    <dbReference type="OMA" id="VTNHFKI"/>
    <dbReference type="OrthoDB" id="10054414at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="227" mass="26228" checksum="96861A635704CD2C" modified="2005-04-12" version="1">MLTSHQKKFHDWFLSFKDSNNYDSKQNHSIKDIFNRFNHYIYNDLGIRTIASDFDLTMMTKHSGGYIDPLDNDGIIFSKSLSKEFNVFGMQAENVNISISVVTFSDPLLIPSNQRERFISGRRMIEHCLKESGAKFKVKNYYCFYPKIWQSQDLYSSIGLDAPMPLFKKYHLLQVASADKLLPNQILFIDDDIRNCKQALQDGFIVLHVEGNAGFSLKSVSVGFYYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY74</accession>
    <name>Q5CY74_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628506.1">
        <property type="nucleotide sequence ID" value="XM_628504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY74"/>
    <dbReference type="GeneID" id="3372057"/>
    <dbReference type="KEGG" id="cpv:cgd7_3420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3420"/>
    <dbReference type="InParanoid" id="Q5CY74"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="166" mass="19422" checksum="CE7729CFB7448F93" modified="2005-04-12" version="1">MRHTRRFTIEIGRCLTFDCYYCEPEKTTLLRSQNDKESSHKINTIDVVKPDYLINRNDLLSSFFPGLYKVTKIQLCKNELLVYAQHDQQFIDISVLEIPAQEKCLFPSTVHETLANETWNFVVVLFRKVKKTTKPKRKRLGASVLARKGQIILVENIRFVRCGKSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY79</accession>
    <name>Q5CY79_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical secreted protein, signal peptide, possible transmembrane domain near C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628501.1">
        <property type="nucleotide sequence ID" value="XM_628499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY79"/>
    <dbReference type="GeneID" id="3372051"/>
    <dbReference type="KEGG" id="cpv:cgd7_3370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3370"/>
    <dbReference type="InParanoid" id="Q5CY79"/>
    <dbReference type="OMA" id="HHINSFM"/>
    <dbReference type="OrthoDB" id="343966at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="316" mass="36830" checksum="0E1E2B7DEAFD4211" modified="2005-04-12" version="1">MILNQTKHIYIMNKLLFAIILVSYIYKFANCFISSFSGPFMLFYSVLRTIDGMAENIQHISNSMDLSLQSFLSTQFLSKISDKVDNPIVIGADYHGSVSPCELDFHPLISSNIFIERSIDKNNTNYFQVINNSSIVLPFTNNKNIQIFESTKYKTENIAGFDSLLFKRMDVNLVNKQNDINNENNYSTLLEPFHYGTKMVSTEFKNQNGNGYVNDLILATKIFNPLQNFEINNKNINNQNIPTRLGKSISSNEIFYNHQYELRETENTEFDLNSFRLYTYYTTHYLFQITSIFSMGISLHSQYRRKSRQRKLHLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY94</accession>
    <name>Q5CY94_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628486.1">
        <property type="nucleotide sequence ID" value="XM_628484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY94"/>
    <dbReference type="GeneID" id="3372298"/>
    <dbReference type="KEGG" id="cpv:cgd7_3210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3210"/>
    <dbReference type="InParanoid" id="Q5CY94"/>
    <dbReference type="OMA" id="KFRTHTT"/>
    <dbReference type="OrthoDB" id="340688at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="233"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="318" mass="35310" checksum="EFC6CA2AA0F91643" modified="2005-04-12" version="1">MFQLRSGPPTSRGASEFGTPNAFSHRNNQVPQYTQRANPLMCCSPPQINSMPINQAPPSRMISAAGLNVQSVNAPSRLVTGASITPAAVVAAPERQVTEPLQHKQTFIYGGSETMEPEDCGWLEPIRLKVHAMEVQQYINPNNPEATPPFIYNVDHLMECVEIPENWAPESVTGVAALTFENLNTNPPVIQHPLRLESDGSRNGTNNPYIQPIRYHVERIKDKDSPEKLEKIIESEQDVTSPSGSKKDNETITSNSNFFSAILSKIKNGVKLTSDKQAISESKEETFENNELEAETVEDEVLTMKQDSTPEHNQFLDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY97</accession>
    <name>Q5CY97_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">T-complex protein 1 subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">CCT-epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_3180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628483.1">
        <property type="nucleotide sequence ID" value="XM_628481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY97"/>
    <dbReference type="FunCoup" id="Q5CY97">
        <property type="interactions" value="518"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY97"/>
    <dbReference type="GeneID" id="3371978"/>
    <dbReference type="KEGG" id="cpv:cgd7_3180"/>
    <dbReference type="InParanoid" id="Q5CY97"/>
    <dbReference type="OMA" id="SHPQMPH"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03339">
        <property type="entry name" value="TCP1_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000003">
        <property type="entry name" value="T-complex protein 1 subunit epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012718">
        <property type="entry name" value="Chap_CCT_epsi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02343">
        <property type="entry name" value="chap_CCT_epsi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00033325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="556" mass="60476" checksum="92BEBB6C53B5528E" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYF3</accession>
    <name>Q5CYF3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sgd1p NIC plus MI domains containing protein involved in RNA metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_2560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628427.1">
        <property type="nucleotide sequence ID" value="XM_628425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYF3"/>
    <dbReference type="STRING" id="353152.Q5CYF3"/>
    <dbReference type="GeneID" id="3371923"/>
    <dbReference type="KEGG" id="cpv:cgd7_2560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2560"/>
    <dbReference type="InParanoid" id="Q5CYF3"/>
    <dbReference type="OMA" id="ISINCEH"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF4">
        <property type="entry name" value="NUCLEOLAR MIF4G DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="3">
        <location>
            <begin position="517"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="734" mass="85171" checksum="A28B6C9841C0C2F9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYK0</accession>
    <name>Q5CYK0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bacterial-like Sir2 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_2030</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628380.1">
        <property type="nucleotide sequence ID" value="XM_628378.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYK0"/>
    <dbReference type="FunCoup" id="Q5CYK0">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYK0"/>
    <dbReference type="GeneID" id="3371798"/>
    <dbReference type="KEGG" id="cpv:cgd7_2030"/>
    <dbReference type="InParanoid" id="Q5CYK0"/>
    <dbReference type="OMA" id="VWAWYLY"/>
    <dbReference type="OrthoDB" id="424302at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017136">
        <property type="term" value="F:histone deacetylase activity, NAD-dependent"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00296">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1600.10">
        <property type="entry name" value="SIR2/SIRT2 'Small Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050134">
        <property type="entry name" value="NAD-dep_sirtuin_deacylases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003000">
        <property type="entry name" value="Sirtuin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026591">
        <property type="entry name" value="Sirtuin_cat_small_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026590">
        <property type="entry name" value="Ssirtuin_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11085:SF10">
        <property type="entry name" value="NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02146">
        <property type="entry name" value="SIR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50305">
        <property type="entry name" value="SIRTUIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0520">NAD</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Deacetylase sirtuin-type" evidence="4">
        <location>
            <begin position="4"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="3">
        <location>
            <position position="137"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00236"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50305"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="299" mass="34330" checksum="C699E5B205985A09" modified="2005-04-12" version="1" fragment="single">TSMNTRIGTVLASLRSEIFDSGKKILFITGAGLSLDSGIPLFRSESDGGDGSAIWNSELEAWATIGSFRKDPIKWYSIFQNNFKFWSSFLTAKPNEGHRVLSKLCSDFPNRIKVITQNIDGLMQQTNCPRENIIEIHGRIHYLRCANPNCDYSSSKFSYIDWKGLFNQDNKIPKDFYLKWSCPSCSSPSLPLFLLFDESYTSHTFYEWEKAQTWMNEADLMIFIGTSFSVLCTDCCLHYAYRNQIPIYNVNIRPAPICFELYNEDGNDFELIEYPNNLLNNITKTSTDFLTALFPRENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYP3</accession>
    <name>Q5CYP3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd7_1560</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628337.1">
        <property type="nucleotide sequence ID" value="XM_628335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYP3"/>
    <dbReference type="FunCoup" id="Q5CYP3">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYP3"/>
    <dbReference type="GeneID" id="3371861"/>
    <dbReference type="KEGG" id="cpv:cgd7_1560"/>
    <dbReference type="InParanoid" id="Q5CYP3"/>
    <dbReference type="OMA" id="WINILRH"/>
    <dbReference type="OrthoDB" id="4096362at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF43">
        <property type="entry name" value="PALMITOYLTRANSFERASE APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="7" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="50"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="200"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="103"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="267" mass="30277" checksum="71DABDA1E7303147" modified="2005-04-12" version="1" fragment="single">NRHSGNKTMSDSQKLDSRYLKILISAILIIGPCILYFISTSKWLFMQHNYLLITLSYILFIIMTTSMVFTFLKNPGVIISQSKLSNPPCSIDLQINAQIVKVKFCSNCKIIRPPRTVHCNICNHCVDRFDHHCPWVGTCIGAGNYKLFMLFISTLFLLELAMLLGSCKMVNHFTYEASHILNLGNSTKIFVHTMNHSAGAAVVIGFACFTILFSLSLLIFHLYIGAMNKTTYEEIKKLYSETSNPWYSGISRNIAELFLSPSPKFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYY3</accession>
    <name>Q5CYY3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein with 2 TPR domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TTC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628247.1">
        <property type="nucleotide sequence ID" value="XM_628245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYY3"/>
    <dbReference type="STRING" id="353152.Q5CYY3"/>
    <dbReference type="GeneID" id="3371915"/>
    <dbReference type="KEGG" id="cpv:cgd7_570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_570"/>
    <dbReference type="InParanoid" id="Q5CYY3"/>
    <dbReference type="OMA" id="WRAAQCA"/>
    <dbReference type="OrthoDB" id="420195at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21377">
        <property type="entry name" value="CTWD_Cns1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044059">
        <property type="entry name" value="Csn1/TTC4_wheel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46035:SF1">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18972">
        <property type="entry name" value="Wheel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="Cns1/TTC4 wheel" evidence="5">
        <location>
            <begin position="267"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="7"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF18972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="390" mass="45321" checksum="BB1F9DE976B2B7A2" modified="2005-04-12" version="1">MEKLEDNSTNSNAPQMITTDEGSVGGVSLYEEDDDIDWEVNPEAVKKLVEKYQGEEFPLFMGEDVLDPNNPHIQALQALVYDDETPESLARQFRTVGNEYFQDGKVRYKDAIIAYTKGIEQKSTDKETNSLLYSNRAHVYLLLKRYVDCVDDCRASLKENPKNVKAAYRGCRASMCMQLYRQALNFALHGLKYEPENPELLKLKSQLEERLSEIEKRRKEREELEKRDGGKNESLQKRDNILNERKYVLGEAIYDVIHTYNHEIKCLKNELVYPILILLDEPMLCEFICEAKESSTLGDHLKVMFPKDRTLPWDTNGRYNWETVSVFYEPGPPHHNTVWEVSIEKSIREILDVVRYIPKIPTIHIIAKNSTCIEEFSKITYNVVRDPLLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ06</accession>
    <name>Q5CZ06_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L18a</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628224.1">
        <property type="nucleotide sequence ID" value="XM_628222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ06"/>
    <dbReference type="SMR" id="Q5CZ06"/>
    <dbReference type="FunCoup" id="Q5CZ06">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CZ06"/>
    <dbReference type="GeneID" id="3371900"/>
    <dbReference type="KEGG" id="cpv:cgd7_320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_320"/>
    <dbReference type="InParanoid" id="Q5CZ06"/>
    <dbReference type="OMA" id="CIFAKND"/>
    <dbReference type="OrthoDB" id="1294322at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00273">
        <property type="entry name" value="Ribosomal_eL20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028877">
        <property type="entry name" value="Ribosomal_eL20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023573">
        <property type="entry name" value="Ribosomal_eL20_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021138">
        <property type="entry name" value="Ribosomal_eL20_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10052">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01775">
        <property type="entry name" value="Ribosomal_L18A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002190">
        <property type="entry name" value="Ribosomal_L18a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160374">
        <property type="entry name" value="RplX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL20" evidence="5">
        <location>
            <begin position="13"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR002190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="185" mass="21465" checksum="44DA869E83C1DBD4" modified="2005-04-12" version="1">MKSMPDPSLQMKVNQYMVIGRGKPTELNPHPKVFRVCIFAPNEVVAKSRFFYFMSRLNKVKKANGEILSVTRIFEKRPTYVKNFAILLQYRSRTNVVYMYKEYRDISKTGAVSQMYEELAGSHRAQRSSIQIIRVSQIDAKLAKRPKTTQFFNSKLKFPAIRKLPMAPKALRSTFTASRPTTFQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ02</accession>
    <name>A3FQ02_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cell differentiation protein rcd1, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_4460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388443.1">
        <property type="nucleotide sequence ID" value="XM_001388406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ02"/>
    <dbReference type="STRING" id="353152.A3FQ02"/>
    <dbReference type="GeneID" id="3374358"/>
    <dbReference type="KEGG" id="cpv:cgd8_4460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4460"/>
    <dbReference type="InParanoid" id="A3FQ02"/>
    <dbReference type="OMA" id="EKVYTWI"/>
    <dbReference type="OrthoDB" id="1183224at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000334">
        <property type="entry name" value="Cell differentiation protein-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007216">
        <property type="entry name" value="CNOT9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12262">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04078">
        <property type="entry name" value="Rcd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="16"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="390" mass="42119" checksum="9825D0037C4E2807" modified="2007-04-03" version="1">MIPQGGLNNSGGGIMAPSSASTAPPSSSSSSSSSSAPSMPLHSSNSMAASVPSSNSASSSNSVPSNSLSASISGKVQQRISQGELGIGGGIPNQISVSGDVGILPSPSDNSGDLKGNENIIQKEREKVYQYLVDMTCSSKREMALSKLSKYRETFPDLAPLMWHSFGCITALLQEIISIYPLLSPPNLSNQASNRTCNCLALLQCVASHSETRAHFLAAHIPLYLYPFLNTVTKSRPFEYLRLTSLGVIGALVKVDDPEVVSFLLQTEIIPLCLRVMETGSELSKTVATFIIQKILLDDLGLTYICATPERFFTVCQVLGNVITQHNEAPSPRLLKHIIRCYLRLSENSKVRDALKQTIPSVILSPSFKMIFHDDGVTTKWLHQLYANIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ14</accession>
    <name>A3FQ14_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_780</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388094.1">
        <property type="nucleotide sequence ID" value="XM_001388057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ14"/>
    <dbReference type="FunCoup" id="A3FQ14">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ14"/>
    <dbReference type="GeneID" id="3373946"/>
    <dbReference type="KEGG" id="cpv:cgd3_780"/>
    <dbReference type="InParanoid" id="A3FQ14"/>
    <dbReference type="OMA" id="YVCSRIN"/>
    <dbReference type="OrthoDB" id="340500at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22526">
        <property type="entry name" value="KH-I_Rrp40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049469">
        <property type="entry name" value="RRP40_KH-I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21262">
        <property type="entry name" value="RRP40_S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0271">Exosome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="119"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="211" mass="23811" checksum="A56869343CA7D063" modified="2007-04-03" version="1" fragment="single">KDFNLKEINSTLYISKVSLNCSHDGILPDMAFEGATKRNKPNLVPGNYVCSRINYVDLESGEIELTCITPEEKKTWSNNENYLGVLKNSNYKNTNIIEDYSKSDRSSLPGESQSCIKDGMTVTVPQSVAQILLADQSYVLEALSKYFAYEICVGQNGIIWFSASNIKEMLLIMSALKVIPNCTKPQVSLNNFFWRAQITYIYLEISSLKLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQC1</accession>
    <name>A3FQC1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388143.1">
        <property type="nucleotide sequence ID" value="XM_001388106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQC1"/>
    <dbReference type="GeneID" id="3371384"/>
    <dbReference type="KEGG" id="cpv:cgd1_620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_620"/>
    <dbReference type="InParanoid" id="A3FQC1"/>
    <dbReference type="OMA" id="MENIMQN"/>
    <dbReference type="OrthoDB" id="343838at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="438" mass="50780" checksum="74FC0CB0368A1DC6" modified="2007-04-03" version="1">MAYLSRRLKAQAITLFFFLIAFISLNEFFSEASSTQQKRELKSVRFVQSGQPPYVSSSKPGQYFRHLQTTVEQDSSSSPDESSPKEQSRLKHVGPKYRFVHAPVGYEKSKSTYLAEIQSLKEANEKLNEEVKSQAQKIKALMAENKELREKIEAELKKTNSSNSKLRSLEEDLKKKERQNNSLSSTLSQKEKTISEQKAEIRSLVQKIQDKETFLESKEKALSELEKQMNNKIEHLQVREKEQEKVKEEKELEVLRLMEKIEVLSANVRENSSKQESLVSEKNQLEARIKELMAERDNANKALNECLESLNAKEVKNEAENVPKETQPEEKRRALYNLVLKQMGRKQMKERWVKAPPLRRPEGINVESDLVPEIVKVFDSLKKKREDEFKAFVTENGLENEDSVKQRQLYEKYKEKNIASSPAGIQQFARFKKESVSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQC9</accession>
    <name>A3FQC9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">ACB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_1140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388151.1">
        <property type="nucleotide sequence ID" value="XM_001388114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQC9"/>
    <dbReference type="SMR" id="A3FQC9"/>
    <dbReference type="STRING" id="353152.A3FQC9"/>
    <dbReference type="GeneID" id="3371491"/>
    <dbReference type="KEGG" id="cpv:cgd1_1140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1140"/>
    <dbReference type="InParanoid" id="A3FQC9"/>
    <dbReference type="OMA" id="ARSKWQA"/>
    <dbReference type="OrthoDB" id="346910at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000062">
        <property type="term" value="F:fatty-acyl-CoA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000582">
        <property type="entry name" value="Acyl-CoA-binding_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035984">
        <property type="entry name" value="Acyl-CoA-binding_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014352">
        <property type="entry name" value="FERM/acyl-CoA-bd_prot_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24119:SF0">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00887">
        <property type="entry name" value="ACBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00689">
        <property type="entry name" value="ACOABINDINGP"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47027">
        <property type="entry name" value="Acyl-CoA binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51228">
        <property type="entry name" value="ACB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ACB" evidence="5">
        <location>
            <begin position="7"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="182"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="215"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="268" mass="29750" checksum="42A876D77E4A6233" modified="2007-04-03" version="1">MTDILSTNKKFASAADYCANNVSSFSNEELLDLYGFYKQATVGDAPEKSGSFFSAFSMKDQAKSKSWASRKGMNPEDAANEYIKLIEKKNPQWEETIGKNSCMSLSNSTSRPLLESNLDEEKLEVELKGVLDQVLLDPNFSEKNCSLSVFDAFCSQVNKNEVEFLKKILERYPFLSNSRSSEGSYALHLACDKGYSEIALLLLKNGANPNVKDNFGDSPLHVSVISEQESCVKVLLKHGADLKLTNDDGLTPIQLSENDQLKRILESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQJ0</accession>
    <name>A3FQJ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Maternal embryonic leucine zipper kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388274.1">
        <property type="nucleotide sequence ID" value="XM_001388237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQJ0"/>
    <dbReference type="STRING" id="353152.A3FQJ0"/>
    <dbReference type="GeneID" id="3373320"/>
    <dbReference type="KEGG" id="cpv:cgd5_2270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2270"/>
    <dbReference type="InParanoid" id="A3FQJ0"/>
    <dbReference type="OMA" id="XLARKEN"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="25"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="327" mass="37959" checksum="32C6E2B1B00A6A6E" modified="2007-04-03" version="1">MNCTLPILKYSRELQQDLLLRNYDILWDVDLGGSEFCRVKLGVRKYNGELVAIKIVTKTFCSNFEKDVVLYIQDKLTSNTSLSEPLNTKSYNEYFPKIFDTFEDIDFIYIVMELSFGGELFHLLVRSEDKLSEETVSLIFSQICSALKALHSIGIMHGDIKAENITFSKESRLDSIKLLDFGNSCLMLANEKSSLGKNNVETPIYNQCFVFNDSKREIQFNQTYFDFWSCGKLLYLMLTGKYLEIDFFECFDFSDSTKKKLFESSELKLCSDLAKDLLYKLLSYSFYQSESLTMDKVLCHPWFNLAKNTPIINHHIYPHDELIKVIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQJ4</accession>
    <name>A3FQJ4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SEC63 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd5_2980</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388278.1">
        <property type="nucleotide sequence ID" value="XM_001388241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQJ4"/>
    <dbReference type="STRING" id="353152.A3FQJ4"/>
    <dbReference type="GeneID" id="3373324"/>
    <dbReference type="KEGG" id="cpv:cgd5_2980"/>
    <dbReference type="InParanoid" id="A3FQJ4"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="SEC63" evidence="8">
        <location>
            <begin position="16"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00973"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="367" mass="42674" checksum="954B289644CBED32" modified="2007-04-03" version="1">MVPQLQEECLIRKGDNQILDQLCRDLNLNLMSNTESSKSSSSSNYQHRSLTSRKIQILLNSYIKRHKFILSRPLVKNDLIDILRFVMDLLFAMVDISSSNGWINTCLRIMELSQMLVQAISNPVNDKLMQLSMLMNKDRIRIFKESGVTDIYDLINMNDDDRDELLTEKLSLSEKEISQIAQVCNDFPIIETEYTILGCNDLNEKNKRRRLDSDNSTNTKNGETQRLFECNPESELTLSIDISRDFSSNEEEDNDLKNQNDIKDQEIYPCIVKNLNYYPLEKEENWWVILIKIAVPNSSKENKDDENEDEILSIRRIQLNKISNQVLLKFNSIEDSGMITNYKLLVICDSYIGCDQEFMFSIKTVES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPH3</accession>
    <name>Q5CPH3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_60</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625320.1">
        <property type="nucleotide sequence ID" value="XM_625320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPH3"/>
    <dbReference type="GeneID" id="3372320"/>
    <dbReference type="KEGG" id="cpv:cgd3_60"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_60"/>
    <dbReference type="InParanoid" id="Q5CPH3"/>
    <dbReference type="OrthoDB" id="10281157at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="249" mass="29399" checksum="0443298DA93BB402" modified="2005-04-12" version="1">MLSKEEILDEIILERLNSAISRVSRCMSCKLNKSKYFDIVENILICKRCLKNSQKFKVVGAHKITSKEIDLLEKNIDQLSFKTNKRAGFSFKNFFSKYFGIKKHSYNSILKEKERMEASRLESENYSDFEWDLFSKEQNFLRRNTFDFCSIYEDEKLVSLPFASNKKYASVDCDGRYVFTNENLNYNFRPLDDDLNCRYKNIGYESSGGLSVNCNDKTYEYNENYYITQDHLNTNNKPNVTSKNPFDLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPK8</accession>
    <name>Q5CPK8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">56 kDa transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_10</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625341.1">
        <property type="nucleotide sequence ID" value="XM_625341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPK8"/>
    <dbReference type="STRING" id="353152.Q5CPK8"/>
    <dbReference type="GeneID" id="3375662"/>
    <dbReference type="KEGG" id="cpv:cgd6_10"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_10"/>
    <dbReference type="InParanoid" id="Q5CPK8"/>
    <dbReference type="OrthoDB" id="344347at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254235" description="56 kDa transmembrane protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="211" mass="22726" checksum="9F62047D7A5CE4AE" modified="2007-04-03" version="1">MFNYLKLFSFFTVLFNFLLLLSDQVFFNDFLNTSINPDFASKYSFIKLKSGFYRPLAGTGGRGILKTAIQLRNTVSGPSGPQQKHVPFKQGPQNPQKGPIPIGSSLGLARLLSRAIGTSSSSSTQFTGSSSGQTGGNSTGFRGIKPLSTSMPRSCYRSSAGDGKIPPCYNPNCRPLVKPVGCLSTNCPTNPSAQHFIKPGAGKRQHCKYCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPL1</accession>
    <name>Q5CPL1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide, serine proline rich, possible low mw mucin glycoprotein locus of 6 genes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625410.1">
        <property type="nucleotide sequence ID" value="XM_625410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPL1"/>
    <dbReference type="STRING" id="353152.Q5CPL1"/>
    <dbReference type="GeneID" id="3372378"/>
    <dbReference type="KEGG" id="cpv:cgd2_430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_430"/>
    <dbReference type="InParanoid" id="Q5CPL1"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253714" evidence="2">
        <location>
            <begin position="26"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="206" mass="21177" checksum="A35DA92C005BE333" modified="2005-04-12" version="1">MNACLYLYIIIPLLYLTFNYQSTFSENFSTDSLTKFSLLKLTASLGNTGSNSNDSDPEDEGPPSFVPPPPPGKKGASGSSPDGRPVPLPRTRHLGGNPPKGLGKAPVPTPRLRDLDGTDGGRKPNCPLGRRGGVRGRDNGPKKDPSQSSDSSSSSSSSSSSSSNSSPDGPVSSSGDGSSGKIIVKKPPGGPPKPPTRSSSLSSLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPM4</accession>
    <name>Q5CPM4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal protein L15</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625397.1">
        <property type="nucleotide sequence ID" value="XM_625397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPM4"/>
    <dbReference type="FunCoup" id="Q5CPM4">
        <property type="interactions" value="438"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPM4"/>
    <dbReference type="GeneID" id="3372358"/>
    <dbReference type="KEGG" id="cpv:cgd2_280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_280"/>
    <dbReference type="InParanoid" id="Q5CPM4"/>
    <dbReference type="OMA" id="YIRDAWK"/>
    <dbReference type="OrthoDB" id="10255148at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1120.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1120.10">
        <property type="entry name" value="Ribosomal protein l15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024794">
        <property type="entry name" value="Rbsml_eL15_core_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000439">
        <property type="entry name" value="Ribosomal_eL15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020925">
        <property type="entry name" value="Ribosomal_eL15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003269">
        <property type="entry name" value="PRK04243.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847:SF4">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11847">
        <property type="entry name" value="RIBOSOMAL PROTEIN L15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00827">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01384">
        <property type="entry name" value="Ribosomal_L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01194">
        <property type="entry name" value="RIBOSOMAL_L15E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="205" mass="24180" checksum="9637047D62F309D3" modified="2005-04-12" version="1">MGAYKYLEELYKRKQSDILRFLMRVRSWEYRQLPAVMRCSHPTRPDKARRLGYKAKQGYVVYRVRVRRGDRKKRVAKGIVYGKPKNQGICKMKSTRNLRAVAEERVGKSICGGLRVLNSYFVCQDATYKFYEVILVDPAHPAIRNDARINYICNPVHKHRQQRGLTAAGRKSRGLQVRGGRAARLRPSRRAVYRRRQLIQLRRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ08</accession>
    <name>Q5CQ08_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acid phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_70</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625471.1">
        <property type="nucleotide sequence ID" value="XM_625471.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ08"/>
    <dbReference type="STRING" id="353152.Q5CQ08"/>
    <dbReference type="GeneID" id="3372490"/>
    <dbReference type="KEGG" id="cpv:cgd8_70"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_70"/>
    <dbReference type="InParanoid" id="Q5CQ08"/>
    <dbReference type="OMA" id="VWSIGNH"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07378">
        <property type="entry name" value="MPP_ACP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024927">
        <property type="entry name" value="Acid_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="34"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="424" mass="48469" checksum="C84148026A20F60F" modified="2005-04-12" version="1">MIGQQMNIRSKYFGLATIFIVSILRYSLCELTVFSIGDWGEKTECLVNVTTKMGSLESAMNPKFIISVGDNFYQRGVKSVEDAAWTEILEEPFGKLSKHLKVHSCLGDHDWRGSTTAQIDRTNYANNTRWYLPGYWWYEKVTFTSEVSLPSLFEKSGLGEISANNSFHFNSSKTENSTSCEIDCLDEIVDNLNTMVNRNNSWNEDLSYKTSISEYFSEKQVNSTAVFIYIDSWTLTQDPFKKTSISYKYSQLEFIEQTLKAAVFENVDWIILVTHYSIYSSGLHGPHTRLASILLPLIKKYRVDFIISGHDHHSEILVPEDFNSYFQIVGASSKPRTSFGATDENSIFKSNTCSFASFTFSKDIAVSRIFSINSSLFSYFKRSNKFERSKLKIEDTQYPHFVSLLRVKPLINVSGWTLSLSLFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ94</accession>
    <name>Q5CQ94_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Hypothetical conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_3660</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625532.1">
        <property type="nucleotide sequence ID" value="XM_625532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ94"/>
    <dbReference type="STRING" id="353152.Q5CQ94"/>
    <dbReference type="GeneID" id="3372540"/>
    <dbReference type="KEGG" id="cpv:cgd5_3660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3660"/>
    <dbReference type="InParanoid" id="Q5CQ94"/>
    <dbReference type="OrthoDB" id="512667at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050821">
        <property type="term" value="P:protein stabilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024158">
        <property type="entry name" value="Mt_import_TIM15"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007853">
        <property type="entry name" value="Znf_DNL-typ"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20922:SF13">
        <property type="entry name" value="DNL-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05180">
        <property type="entry name" value="zf-DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51501">
        <property type="entry name" value="ZF_DNL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNL-type" evidence="5">
        <location>
            <begin position="113"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00834"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="186" mass="21497" checksum="6490414A382F76E9" modified="2005-04-12" version="1">MVHKMIIQSKNFVMARRVLGTSLPLITRRSLFKSGGDIFGRIRSNKWITNTFVRSFTMPISCKKFISTINNKFTESKMEIKSKQACSNYDNNELKDNQEKVDLNNIQGTLDYGEDGLYVFSCVCNVCNSKITKKFSKKAYNEGIVIIRCDNCKNHHLVSDKLGWFEDNKDNFDVFKYINNKEISVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQA1</accession>
    <name>Q5CQA1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alkyl transferase</fullName>
            <ecNumber evidence="3">2.5.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_1510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the UPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.-" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625747.1">
        <property type="nucleotide sequence ID" value="XM_625747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQA1"/>
    <dbReference type="FunCoup" id="Q5CQA1">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQA1"/>
    <dbReference type="GeneID" id="3372705"/>
    <dbReference type="KEGG" id="cpv:cgd4_1510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1510"/>
    <dbReference type="InParanoid" id="Q5CQA1"/>
    <dbReference type="OMA" id="TKGQPDP"/>
    <dbReference type="OrthoDB" id="4173905at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045547">
        <property type="term" value="F:ditrans,polycis-polyprenyl diphosphate synthase [(2E,6E)-farnesyl diphosphate specific] activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016094">
        <property type="term" value="P:polyprenol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00475">
        <property type="entry name" value="Cis_IPPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1180.10">
        <property type="entry name" value="Decaprenyl diphosphate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001441">
        <property type="entry name" value="UPP_synth-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036424">
        <property type="entry name" value="UPP_synth-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00055">
        <property type="entry name" value="uppS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291:SF43">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE COMPLEX SUBUNIT DHDDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10291">
        <property type="entry name" value="DEHYDRODOLICHYL DIPHOSPHATE SYNTHASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01255">
        <property type="entry name" value="Prenyltransf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64005">
        <property type="entry name" value="Undecaprenyl diphosphate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU363018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="252" mass="29446" checksum="3B3E423B0C3DDD9D" modified="2005-04-12" version="1">MISLIKRVLEIVLTRFLSIFKINHVAIILDGNRRYAKAMGISQLEGHKQGALLIKKILPLFIKLKVKYISMFVFSMENFSRNQENVDDTFNVIKDYILKEGNWLNEKNSKVVISGKIEMLPKELLDTLKDLELKTKENNGIVLNICCAYSWTAELEMASKKYLENYKNVNSNNINQIQDITLSDEKFKSFIYNPEIPFPNILIRTSGETRLSDFLIYQVCHNTRIYFVKTLWPQINPLNILIVILHYVIFYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQD9</accession>
    <name>Q5CQD9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">WD40 repeat containing protein that has a transmembrane region at the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd4_1120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625709.1">
        <property type="nucleotide sequence ID" value="XM_625709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQD9"/>
    <dbReference type="STRING" id="353152.Q5CQD9"/>
    <dbReference type="GeneID" id="3372620"/>
    <dbReference type="KEGG" id="cpv:cgd4_1120"/>
    <dbReference type="InParanoid" id="Q5CQD9"/>
    <dbReference type="OMA" id="DDRPCCN"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003400">
        <property type="term" value="P:regulation of COPII vesicle coating"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045260">
        <property type="entry name" value="Sec12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23284:SF0">
        <property type="entry name" value="PROLACTIN REGULATORY ELEMENT-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 12 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <keyword evidence="3 11" id="KW-0853">WD repeat</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="178"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK87720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="449" mass="50979" checksum="20488E37F91DF062" modified="2005-04-12" version="1" fragment="single">SNIMPIYYADYPIFGLCCTRDSIILSGGGGGKDYGIEDQIELYELKDCEVECQKLNANDKISAESSLMLKYIYNTTKQNGVLDSMCFNNKLNLVAGGIRDCCILFYIEEEKQGKSIRMYLQFQTVWDGNKKGKQNVCRFSKNGEFLITGGTDNIVRVWKLNIDSENPREIIPLEMKELHGHENEILDLDISPDNKFIISTNRNGTIIVHEYNSGDIFKKFTIPMKNGNYLVRQCRFIENGRLNSPRRQKNNDRQQYIVSMLLHEIRGSSFMTVWNMKISKENSNENPNNRILFAQIASNLICDKPSSVLVVSDDYKLLAVGTNTGLIKIFKNNLTELTLLKEGIFHELPVTGLQFFNSNEYIISAGADYSISVLEIKSRKNSAKSNNKQMNIAKSNQNGGMFGFGLNIIKYTLLTIFIIMFITTFINYSIEIGVNIQSSIRDGDQSTEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQE8</accession>
    <name>Q5CQE8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">mitogen-activated protein kinase kinase</fullName>
            <ecNumber evidence="6">2.7.12.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd4_990</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10596"/>
            <dbReference type="Rhea" id="RHEA-COMP:10136"/>
            <dbReference type="Rhea" id="RHEA-COMP:20101"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:46858"/>
            <dbReference type="ChEBI" id="CHEBI:61978"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.12.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.12.2" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625700.1">
        <property type="nucleotide sequence ID" value="XM_625700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQE8"/>
    <dbReference type="STRING" id="353152.Q5CQE8"/>
    <dbReference type="GeneID" id="3372683"/>
    <dbReference type="KEGG" id="cpv:cgd4_990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_990"/>
    <dbReference type="InParanoid" id="Q5CQE8"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004708">
        <property type="term" value="F:MAP kinase kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013:SF9">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48013">
        <property type="entry name" value="DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="99"/>
            <end position="317"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00051693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="317" mass="36882" checksum="76666605D1D1E21B" modified="2005-04-12" version="1">MELSETKLEDINHNSEFNKDNYYNEKNNLNHNLEVNNLDIQEVNNRRSSTRCSIKMRTSLVDDLHQLMPRVVTLERNDQGQIKYNLKVPAGELINSSQFEFVNLISSGGFGVVNLCKSNNLGNLPNGREIAVKLFTRGGKEGGSNQLSDERLKSIESELNYVRMFKHPNIIEYYGILNPSTGQIGFAMEYLDGGTVFEVLYSKINIIPLEIRKMWCVQLVKAVAYLHEGCAPYRFIHRDIKTINMLINRKDLSIRLCDFGNVRERTFSYYRLNYMGTVRYLPRSAKWFIIMKNRVWQWSGDEILKWDPLSKFNDDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQI4</accession>
    <name>Q5CQI4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Nuclear transport factor 2</fullName>
            <shortName evidence="2">NTF-2</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2007" name="Mol. Biochem. Parasitol." volume="151" first="100" last="110">
            <title>Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.</title>
            <authorList>
                <person name="Vedadi M."/>
                <person name="Lew J."/>
                <person name="Artz J."/>
                <person name="Amani M."/>
                <person name="Zhao Y."/>
                <person name="Dong A."/>
                <person name="Wasney G.A."/>
                <person name="Gao M."/>
                <person name="Hills T."/>
                <person name="Brokx S."/>
                <person name="Qiu W."/>
                <person name="Sharma S."/>
                <person name="Diassiti A."/>
                <person name="Alam Z."/>
                <person name="Melone M."/>
                <person name="Mulichak A."/>
                <person name="Wernimont A."/>
                <person name="Bray J."/>
                <person name="Loppnau P."/>
                <person name="Plotnikova O."/>
                <person name="Newberry K."/>
                <person name="Sundararajan E."/>
                <person name="Houston S."/>
                <person name="Walker J."/>
                <person name="Tempel W."/>
                <person name="Bochkarev A."/>
                <person name="Kozieradzki I."/>
                <person name="Edwards A."/>
                <person name="Arrowsmith C."/>
                <person name="Roos D."/>
                <person name="Kain K."/>
                <person name="Hui R."/>
            </authorList>
            <dbReference type="PubMed" id="17125854"/>
            <dbReference type="DOI" id="10.1016/j.molbiopara.2006.10.011"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="2">Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625664.1">
        <property type="nucleotide sequence ID" value="XM_625664.1"/>
    </dbReference>
    <dbReference type="PDB" id="1ZO2">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.60 A"/>
        <property type="chains" value="A/B=1-129"/>
    </dbReference>
    <dbReference type="PDBsum" id="1ZO2"/>
    <dbReference type="AlphaFoldDB" id="Q5CQI4"/>
    <dbReference type="SMR" id="Q5CQI4"/>
    <dbReference type="FunCoup" id="Q5CQI4">
        <property type="interactions" value="480"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQI4"/>
    <dbReference type="GeneID" id="3372754"/>
    <dbReference type="KEGG" id="cpv:cgd4_590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_590"/>
    <dbReference type="InParanoid" id="Q5CQI4"/>
    <dbReference type="OMA" id="QFVEYYY"/>
    <dbReference type="OrthoDB" id="6507044at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CQI4"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00780">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.450.50:FF:000005">
        <property type="entry name" value="Nuclear transport factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045875">
        <property type="entry name" value="NTF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12612">
        <property type="entry name" value="NUCLEAR TRANSPORT FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1 2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="NTF2" evidence="3">
        <location>
            <begin position="14"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU369002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="1ZO2"/>
        </source>
    </evidence>
    <sequence length="129" mass="14689" checksum="3E0179B65E504CFF" modified="2005-04-12" version="1">MDQSINLNPQFDQIGKQFVQHYYQTFQTNRPALGGLYGPQSMLTWEDTQFQGQANIVNKFNSLNFQRVQFEITRVDCQPSPNNGSIVFVTGDVRIDDGQPLKFSQVFNLMPSGNGGFMIFNDLFRLNLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQN3</accession>
    <name>Q5CQN3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_50</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625615.1">
        <property type="nucleotide sequence ID" value="XM_625615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQN3"/>
    <dbReference type="GeneID" id="3372606"/>
    <dbReference type="KEGG" id="cpv:cgd4_50"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_50"/>
    <dbReference type="InParanoid" id="Q5CQN3"/>
    <dbReference type="OrthoDB" id="10334729at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="156"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="156"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="182" mass="21646" checksum="FC204FC5E2631D17" modified="2005-04-12" version="1">MVYPDDEEFRLRIIDARMVAKEIRKERNKKLKEFNNDGIYDKVFGFNIPVRPDVKELLEMKRLNELILPPRWDPLDGRLDHEFDHARYIKIRKQFEDILPIAGTSIISAEEVERNFMKWYNEGLSIESSKRYNHTSMVGSKYIIDGESEVKDFTFQSRNGKNMSVQNNRQEKSKSLSQRKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQR2</accession>
    <name>Q5CQR2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625940.1">
        <property type="nucleotide sequence ID" value="XM_625940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQR2"/>
    <dbReference type="GeneID" id="3372809"/>
    <dbReference type="KEGG" id="cpv:cgd4_3640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3640"/>
    <dbReference type="InParanoid" id="Q5CQR2"/>
    <dbReference type="OrthoDB" id="10339110at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="189" mass="21456" checksum="65991D78F130827F" modified="2005-04-12" version="1">MNLKVISVCLAQLKEIEGQSDPVGMANYKQFKRLMQSVNAVNKANENFLKFIIKLETEMSIASSLISELGILLLKCIESILLESTKLSEIHHFIKNLKLMNKMIRNITRHVQSVFNKYCQERSLRTLEESILGLKSQLSKKQKTKSQSSTHSSVTSTSTSTPRSRPTRPKAYMAQTLSSKTKGREKYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQS8</accession>
    <name>Q5CQS8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_3480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625924.1">
        <property type="nucleotide sequence ID" value="XM_625924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQS8"/>
    <dbReference type="GeneID" id="3372863"/>
    <dbReference type="KEGG" id="cpv:cgd4_3480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3480"/>
    <dbReference type="InParanoid" id="Q5CQS8"/>
    <dbReference type="OMA" id="ERHYYNI"/>
    <dbReference type="OrthoDB" id="338599at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254129" evidence="2">
        <location>
            <begin position="24"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="335"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="368" mass="42965" checksum="B52FD31D3802D619" modified="2005-04-12" version="1">MVKNHSIVLIFLTLILLWTLDNGIIGVFCKKKSKYKIDNPELGPESNLDRSKRLREEIFEPSEFGIIKSDRLQIIESEYGSITQLPIRGHQSFDTSRIRSQSILSDQNNGIELIKPYEGVYVDYNLTSFSNFISRIVEMDLEMHLTFKEVTDRKLSIRRREREVLSHLNTQSNTKNSREQSHEKLNSIEFHNISFLFLAGYFKNENKSSGYGNSLQDFVLVFKDSITLSRQNANQYYAKYGITTFKDRLTAVMNSEESMSVKHKDLFSDGKINVDHHKLSFLYLPHNETRLYFSMDGTQRLILPKLHIKAIQTHQEADDKPELPSKDEDSNSKKVVIITFLIFTMFTSFIILFYIIITWYFRGIQKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQU4</accession>
    <name>Q5CQU4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Articulin family protein, adjacent paralogous protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625908.1">
        <property type="nucleotide sequence ID" value="XM_625908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQU4"/>
    <dbReference type="GeneID" id="3372782"/>
    <dbReference type="KEGG" id="cpv:cgd4_3290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3290"/>
    <dbReference type="InParanoid" id="Q5CQU4"/>
    <dbReference type="OMA" id="HPLEMVH"/>
    <dbReference type="OrthoDB" id="341024at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022086">
        <property type="entry name" value="IMCp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12314">
        <property type="entry name" value="IMCp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="515" mass="58256" checksum="B64F6CB6EA1B2FBA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQX3</accession>
    <name>Q5CQX3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625879.1">
        <property type="nucleotide sequence ID" value="XM_625879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQX3"/>
    <dbReference type="GeneID" id="3372993"/>
    <dbReference type="KEGG" id="cpv:cgd4_2940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2940"/>
    <dbReference type="InParanoid" id="Q5CQX3"/>
    <dbReference type="OrthoDB" id="343765at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="13"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="109" mass="12621" checksum="8FEFCBEEFF94643B" modified="2005-04-12" version="1">MPDKDKEIKVLKMQLDSNLSIAYLKLQDYPNAIHYANKALEYESNNLKALHHKCIALFELSEYKQCVECADIALKVEPNNVVFKKVRYNALLKQKQYISKSKKIVSCTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQX5</accession>
    <name>Q5CQX5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625877.1">
        <property type="nucleotide sequence ID" value="XM_625877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQX5"/>
    <dbReference type="GeneID" id="3372995"/>
    <dbReference type="KEGG" id="cpv:cgd4_2920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2920"/>
    <dbReference type="InParanoid" id="Q5CQX5"/>
    <dbReference type="OMA" id="IMRIDST"/>
    <dbReference type="OrthoDB" id="340000at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="171"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="254"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="456"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="607" mass="70668" checksum="6208F2F8B8E180D9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR29</accession>
    <name>Q5CR29_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Multitransmembrane protein with signal peptide and GMGPP repeat at C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87862.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625823.1">
        <property type="nucleotide sequence ID" value="XM_625823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR29"/>
    <dbReference type="STRING" id="353152.Q5CR29"/>
    <dbReference type="GeneID" id="3372888"/>
    <dbReference type="KEGG" id="cpv:cgd4_2350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2350"/>
    <dbReference type="InParanoid" id="Q5CR29"/>
    <dbReference type="OMA" id="FYIFMIT"/>
    <dbReference type="OrthoDB" id="343068at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="207"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87862.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="350" mass="36897" checksum="F5CD79650575F9F3" modified="2005-04-12" version="1">MSHNASSRNQGGDTGLGIGWKLLAAVGFTAIVLQIISIILNGWRVAPAITYQYYQKSTLKSWQLQSSEYGLYIYKFNNGASTRPWSTVEQFVCSWIDSYVSISQVEQSLWGSTCSTDCQTALRTRCTSYVKFANGGYLCLGALVISIIVGIVGVVWLFVFGKSRNFLLFAWSTSSILSSSGIAYWCYTTSQAIKGIIGTQQYPYPSLGYGAYLGILSTVCFIICAFGVLVVHYLESKAAMDARQAELMKEAAANNEWMGQSGMSPPGMGPPGMGPPGMGPPGMGPPGMGPPGMGPPGMGPPGMGPPGMGPPGMGPPGMGPPGMGPPGMGPRGMGNNMINMQGMMPGASRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRB0</accession>
    <name>Q5CRB0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DnaJ domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_3530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626276.1">
        <property type="nucleotide sequence ID" value="XM_626276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRB0"/>
    <dbReference type="SMR" id="Q5CRB0"/>
    <dbReference type="STRING" id="353152.Q5CRB0"/>
    <dbReference type="GeneID" id="3373080"/>
    <dbReference type="KEGG" id="cpv:cgd5_3530"/>
    <dbReference type="InParanoid" id="Q5CRB0"/>
    <dbReference type="OMA" id="DEDIEYC"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45188">
        <property type="entry name" value="DNAJ PROTEIN P58IPK HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="domain" description="J" evidence="3">
        <location>
            <begin position="23"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="187" mass="22107" checksum="48B8B33370D5EF58" modified="2005-04-12" version="1" fragment="single">TRIKIQSKLCEMPGSTYIEKIKTHYDTLELKKDCSKEDICRAYMRLALEWYPDGNRSDTELKGTMFKKISNAYQILSNDELRRKYDSSIDELIKKNSSEMNQNLNFDPYEVFEKFMTEVLADKEKYYQYSSPCNGGFYIHSNSDFNSDSDIEFGLDGDEKDANINDDLFTEDEDIEYCDDYHYRNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRU2</accession>
    <name>Q5CRU2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 14">Nucleoside diphosphate kinase</fullName>
            <ecNumber evidence="3 14">2.7.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd5_1470</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + ATP = a 2'-deoxyribonucleoside 5'-triphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:44640"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 13">Belongs to the NDK family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.6" evidence="3 14"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626094.1">
        <property type="nucleotide sequence ID" value="XM_626094.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRU2"/>
    <dbReference type="STRING" id="353152.Q5CRU2"/>
    <dbReference type="GeneID" id="3373094"/>
    <dbReference type="KEGG" id="cpv:cgd5_1470"/>
    <dbReference type="InParanoid" id="Q5CRU2"/>
    <dbReference type="OMA" id="LLNWECC"/>
    <dbReference type="OrthoDB" id="270127at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006241">
        <property type="term" value="P:CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006228">
        <property type="term" value="P:UTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04413">
        <property type="entry name" value="NDPk_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.141:FF:000003">
        <property type="entry name" value="Nucleoside diphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.141">
        <property type="entry name" value="Nucleoside diphosphate kinase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00451">
        <property type="entry name" value="NDP_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034907">
        <property type="entry name" value="NDK-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036850">
        <property type="entry name" value="NDK-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001564">
        <property type="entry name" value="Nucleoside_diP_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023005">
        <property type="entry name" value="Nucleoside_diP_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001908">
        <property type="entry name" value="PRK00668.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11349">
        <property type="entry name" value="NUCLEOSIDE DIPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00334">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01243">
        <property type="entry name" value="NUCDPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00562">
        <property type="entry name" value="NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54919">
        <property type="entry name" value="Nucleoside diphosphate kinase, NDK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00469">
        <property type="entry name" value="NDPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51374">
        <property type="entry name" value="NDPK_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 14 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16" id="KW-0732">Signal</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="16">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254308" description="Nucleoside diphosphate kinase" evidence="16">
        <location>
            <begin position="40"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleoside diphosphate kinase-like" evidence="17">
        <location>
            <begin position="88"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="41"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="46"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="active site" description="Pros-phosphohistidine intermediate" evidence="12">
        <location>
            <position position="202"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="96"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="144"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="172"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="199"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAK88246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="237" mass="26621" checksum="BB279E7344BB18B8" modified="2005-04-12" version="1" fragment="single">WINCYGASHFFGLVTMQKSLLFLTFLYLLCSIFVGSSHSEEVPAPSNSTESSLSSEDLVSDTQEQTSTNETAVETVAETSPQSTNPFAERTLVLFKPEVTHRGLIGEILSQIERKGFKIAAMKFLVATAQQIEAHYSDHAGKPFFESLVSRTTNQPIVAMVLEGLNVISEFRRFMGSTDPKKSEMGTLRAQFGMQTERNLIHASDSVENANLEIFLWFSPDEIYSYQRAIDQFVYFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRU7</accession>
    <name>Q5CRU7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626089.1">
        <property type="nucleotide sequence ID" value="XM_626089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRU7"/>
    <dbReference type="GeneID" id="3373284"/>
    <dbReference type="KEGG" id="cpv:cgd5_1420"/>
    <dbReference type="InParanoid" id="Q5CRU7"/>
    <dbReference type="OMA" id="FENERHR"/>
    <dbReference type="OrthoDB" id="340142at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="401"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="735" mass="84495" checksum="EB005C8AEEEA9092" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRV6</accession>
    <name>Q5CRV6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved protein with possible signal peptide and ER retention motif possible ER protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_1310</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626080.1">
        <property type="nucleotide sequence ID" value="XM_626080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRV6"/>
    <dbReference type="GeneID" id="3373294"/>
    <dbReference type="KEGG" id="cpv:cgd5_1310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1310"/>
    <dbReference type="InParanoid" id="Q5CRV6"/>
    <dbReference type="OMA" id="KCWFNVT"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254457" evidence="2">
        <location>
            <begin position="21"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="113"/>
            <end position="214"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="271" mass="31214" checksum="4BA23D35B0D2908E" modified="2005-04-12" version="1">MLTYFFSLFLIVFLGSFTFCEQLGHNNTSIFASSQTEADAIQIFEKLTRNIIADDLNTSISRGWWILSRKLIIKTHEQGIDLSPVVRSVELSIRRELNELTRLLNKKHSEIATLSPAFQWAQSSDQVYLNIKFTYRWNAPGALKIENETVSIRDNIFFFSAMGSHSHEKKKYVLKLELFDNIDSDLSEWSFGSVGKLSCTLVKKEPNTIWPRLLKDQKLKIPNMHVWWEMKEKHENLTANSSISNGTKTSNVLNNTDSFENDVISTAREEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRW6</accession>
    <name>Q5CRW6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626070.1">
        <property type="nucleotide sequence ID" value="XM_626070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRW6"/>
    <dbReference type="STRING" id="353152.Q5CRW6"/>
    <dbReference type="GeneID" id="3373066"/>
    <dbReference type="KEGG" id="cpv:cgd5_1210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1210"/>
    <dbReference type="InParanoid" id="Q5CRW6"/>
    <dbReference type="OMA" id="MMTNNTM"/>
    <dbReference type="OrthoDB" id="344354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="149"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="385"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="300"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="410" mass="44618" checksum="FBF82DED8536AC93" modified="2005-04-12" version="1">MDLNNIPFLPKKEFFKPYYTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTEANLFLNASNVGKIASVNRRLRENTNSSQKASKSSLFNQIDLNNISFLPKKEFFKPYYTTSTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTATTASINSSLSNTLMLLSQNNNRLQPTNTQLNDDSNLIIPAQKKLLNTTSPEATKETNKTYDNNSDAKNRINQSNNATDKRSEKQTDLLQNQHIFKKYTTTTTTPANVINNVSNSSQSQYNGTNINSLNSTESNPNYIKDKSDQLDRAPGSSNTMNQTTNLNNERYISSSLILTNGTSQGKFALSPLNGTEVAPLFSKFVPNEDTSDSVKFGYSSPPSLNNDKNSSQSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSA2</accession>
    <name>Q5CSA2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Gbp1/Gbp2p-like, putative single stranded G-strand telomeric DNA-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_3530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628165.1">
        <property type="nucleotide sequence ID" value="XM_628165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSA2"/>
    <dbReference type="FunCoup" id="Q5CSA2">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSA2"/>
    <dbReference type="GeneID" id="3371576"/>
    <dbReference type="KEGG" id="cpv:cgd1_3530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3530"/>
    <dbReference type="InParanoid" id="Q5CSA2"/>
    <dbReference type="OMA" id="KGWGIVE"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF3">
        <property type="entry name" value="FI21236P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="7"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="122"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="89"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="198" mass="22986" checksum="ED91E2D0411B338C" modified="2007-04-03" version="1">MVSDKNCRVYVGNLPWKAKWHDLKDHMRQAGNVIRADVFEDEVGRSRGCGVVEYSFPEEAQRAINELNNTTLLDRLIFVREDREDESSRYGRRSNKWNNRGYGMRTRTHAPRPPLKEENKGKQVFVTNLAWKTTQEDLAKAFNEIGPLESCEVFYFEDGRSRGIATIVFTDPNHAQLAVEKLNDREIDGREILVRIDQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSA9</accession>
    <name>Q5CSA9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]</fullName>
            <ecNumber evidence="9">1.3.1.88</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd1_3440</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5,6-dihydrouridine(16) in tRNA + NAD(+) = uridine(16) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53380"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="12">
            <dbReference type="Rhea" id="RHEA:53382"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>5,6-dihydrouridine(16) in tRNA + NADP(+) = uridine(16) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53376"/>
            <dbReference type="Rhea" id="RHEA-COMP:13543"/>
            <dbReference type="Rhea" id="RHEA-COMP:13544"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="11">
            <dbReference type="Rhea" id="RHEA:53378"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>5,6-dihydrouridine(17) in tRNA + NAD(+) = uridine(17) in tRNA + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53372"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="10">
            <dbReference type="Rhea" id="RHEA:53374"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>5,6-dihydrouridine(17) in tRNA + NADP(+) = uridine(17) in tRNA + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53368"/>
            <dbReference type="Rhea" id="RHEA-COMP:13541"/>
            <dbReference type="Rhea" id="RHEA-COMP:13542"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74443"/>
            <dbReference type="EC" id="1.3.1.88"/>
        </reaction>
        <physiologicalReaction direction="right-to-left" evidence="13">
            <dbReference type="Rhea" id="RHEA:53370"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Dus family. Dus1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.3.1.88" evidence="9"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628158.1">
        <property type="nucleotide sequence ID" value="XM_628158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSA9"/>
    <dbReference type="FunCoup" id="Q5CSA9">
        <property type="interactions" value="399"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSA9"/>
    <dbReference type="GeneID" id="3371448"/>
    <dbReference type="KEGG" id="cpv:cgd1_3440"/>
    <dbReference type="InParanoid" id="Q5CSA9"/>
    <dbReference type="OMA" id="QRPHHDI"/>
    <dbReference type="OrthoDB" id="272303at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017150">
        <property type="term" value="F:tRNA dihydrouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02801">
        <property type="entry name" value="DUS_like_FMN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035587">
        <property type="entry name" value="DUS-like_FMN-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018517">
        <property type="entry name" value="tRNA_hU_synthase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082">
        <property type="entry name" value="TRNA-DIHYDROURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11082:SF5">
        <property type="entry name" value="TRNA-DIHYDROURIDINE(16_17) SYNTHASE [NAD(P)(+)]-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01207">
        <property type="entry name" value="Dus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51395">
        <property type="entry name" value="FMN-linked oxidoreductases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01136">
        <property type="entry name" value="UPF0034"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="3" id="KW-0288">FMN</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DUS-like FMN-binding" evidence="14">
        <location>
            <begin position="23"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038890"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00049467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF01207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK88548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="409" mass="46824" checksum="25793A9004475DD6" modified="2005-04-12" version="1" fragment="single">RKMTKLSPWENWKNVLKSPKTVLAPMVDGSELAFRLICKKYGCDLGYSPMYHSGLFSKLQGYRETNFQTCEEDDPMIVQFCGNDPETLVKASKFIDDKVKGIDINFGCPQNIAKRGNYGAFLLSNPDLMERIISTLSESDLKCPVSCKIRILDHHDLQPTINLIKRLESAGACMIAVHGRTMTSRGVLTGPANWEALKILKSRCSIPFIANGGISNYEDIQKCLNYTGADAVMSAEGILENPWLFQGFKTPEAINNKPSQFQIALEYLDYCILYPPPNVGIIRTHLYRIFHTIFSLPGAHIFRDEINNSHQVHEFQLFVQNLENFYNTKIVHELRNFSGKIPQIGFWYIRHRHDKLDHNVTRELISIYNYQRQKLPTILQFNECDMTDVKVSNNLEIQSDDDISNLFSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSD4</accession>
    <name>Q5CSD4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628133.1">
        <property type="nucleotide sequence ID" value="XM_628133.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CSD4">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSD4"/>
    <dbReference type="GeneID" id="3371465"/>
    <dbReference type="KEGG" id="cpv:cgd1_3170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3170"/>
    <dbReference type="InParanoid" id="Q5CSD4"/>
    <dbReference type="OMA" id="CIRPFPT"/>
    <dbReference type="OrthoDB" id="360742at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF26">
        <property type="entry name" value="CYSTEINE-RICH PROTEIN 2-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="146"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1394"/>
            <end position="1489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1570"/>
            <end position="1604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1268"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1397"/>
            <end position="1408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1417"/>
            <end position="1466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1570"/>
            <end position="1580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1585"/>
            <end position="1598"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1619" mass="187258" checksum="A28FAE9FA5DADC41" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT25</accession>
    <name>Q5CT25_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oxysterol binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627892.1">
        <property type="nucleotide sequence ID" value="XM_627892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT25"/>
    <dbReference type="GeneID" id="3371379"/>
    <dbReference type="KEGG" id="cpv:cgd1_320"/>
    <dbReference type="InParanoid" id="Q5CT25"/>
    <dbReference type="OMA" id="LKVWSLI"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="590" mass="67689" checksum="8D77E2D722F07B90" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT54</accession>
    <name>Q5CT54_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide, repeats, gene anchored to telomere</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_4380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626615.1">
        <property type="nucleotide sequence ID" value="XM_626615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT54"/>
    <dbReference type="STRING" id="353152.Q5CT54"/>
    <dbReference type="GeneID" id="3373705"/>
    <dbReference type="KEGG" id="cpv:cgd2_4380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4380"/>
    <dbReference type="InParanoid" id="Q5CT54"/>
    <dbReference type="OrthoDB" id="10483477at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="309"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="477" mass="50165" checksum="7D25C543063F818E" modified="2005-04-12" version="1">MGNSLNVFFAIFLVVFLNFLGLQTFFNTRNVESNLFLILNSYPSFIKLGGINGREGSSSGFSSGGRHGSLQGGSLRDSARSRGGPRCSRAPHPRLQTIIECSETDSTDGGSNTASQPNGRFLNPGYGSRPGSTRGPTLGLFTRSRPVFPTRRPYSGILLTSSGSKSSALSSRFGQKPSSSHSTSTGTRALQSGVGSRFLSPGYGSRPGSTRGPTLGLFTRSRPVFPTRRPYSGSLFTSSSFRSSNASDGSGDSSYSSRFTGTGTRGSQGGVGSRFLSPGYGLQPGSARGPTLGLFTRSRPPLPTRKPYSGSLLTSSRLSSSNASGGLGQSSSSSRFTSTGPQGPYGTSGVGTPLGHSVSPEGKPQGLLARGYITSNCPRGIPGEHRVDVTSNGSLICCYCYNRCDHEGFKPPRRTTTTTTQSPPYSSRGYLTLDCPLGTPGEHRLDVDNSGVLFCATCGNRFSHQGCPPPKIPLCRK</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-09-22" modified="2025-02-05" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT62</accession>
    <name>SLX1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Structure-specific endonuclease subunit SLX1 homolog</fullName>
            <ecNumber evidence="1">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">cgd2_4280</name>
    </gene>
    <organism>
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalytic subunit of a heterodimeric structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Forms a heterodimer with a member of the SLX4 family.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLX1 family.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626607.1">
        <property type="nucleotide sequence ID" value="XM_626607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT62"/>
    <dbReference type="SMR" id="Q5CT62"/>
    <dbReference type="STRING" id="353152.Q5CT62"/>
    <dbReference type="EnsemblProtists" id="EAK88615">
        <property type="protein sequence ID" value="EAK88615"/>
        <property type="gene ID" value="cgd2_4280"/>
    </dbReference>
    <dbReference type="GeneID" id="3373476"/>
    <dbReference type="KEGG" id="cpv:cgd2_4280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4280"/>
    <dbReference type="InParanoid" id="Q5CT62"/>
    <dbReference type="OMA" id="HNRGCDF"/>
    <dbReference type="OrthoDB" id="24645at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033557">
        <property type="term" value="C:Slx1-Slx4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017108">
        <property type="term" value="F:5'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd10455">
        <property type="entry name" value="GIY-YIG_SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1440.10">
        <property type="entry name" value="GIY-YIG endonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03100">
        <property type="entry name" value="Endonuc_su_Slx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000305">
        <property type="entry name" value="GIY-YIG_endonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035901">
        <property type="entry name" value="GIY-YIG_endonuc_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027520">
        <property type="entry name" value="Slx1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050381">
        <property type="entry name" value="SLX1_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20208:SF13">
        <property type="entry name" value="STRUCTURE-SPECIFIC ENDONUCLEASE SUBUNIT SLX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01541">
        <property type="entry name" value="GIY-YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50164">
        <property type="entry name" value="GIY_YIG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0227">DNA damage</keyword>
    <keyword id="KW-0233">DNA recombination</keyword>
    <keyword id="KW-0234">DNA repair</keyword>
    <keyword id="KW-0255">Endonuclease</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0540">Nuclease</keyword>
    <keyword id="KW-0539">Nucleus</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000383761" description="Structure-specific endonuclease subunit SLX1 homolog">
        <location>
            <begin position="1"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="GIY-YIG" evidence="1">
        <location>
            <begin position="6"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03100"/>
        </source>
    </evidence>
    <sequence length="410" mass="47943" checksum="F4241C7FD16BB459" modified="2005-04-12" version="1">MKSNIQLHYCYFLLSEAKKKASYIGYSVNPCRRLRQHNGEIKKGAKKTKSGVPWNLGICVGGFPDRVAALRFEWAWQHPNICKVTRDNIESWKIVKTKKTSENKRILNKRQWSIQQRVSILLCMTTLEPWKNMNLTVFVFKDELENTIKEVIEGIKKIKISPNFTSPNILNKDYLLMFLYFGEDSFYEKGIKFLRCDYETFKEFQKPSFDCDSDSNIEDNSNVFNPEEIISHEDSFSIKCFLCQKDIGIGRNYLEFPCCTEIKVHLSCIQLWGESNNHLETVIDELFPLKEFVAPLIPLNISCPCCFKDFEWEEAKKNYIKTKNVPTESLELGEDFPVLSNGEKENYSQEENSQNKVIEDGFLEMDIDNHRNRLSYAHETKQKRDILFSDDEFSEISQKCEFIDLTVDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT71</accession>
    <name>Q5CT71_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DEXDc+HELICc, mus308/POLQ like SFII DNA helicase, no polymerase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd2_4190</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626598.1">
        <property type="nucleotide sequence ID" value="XM_626598.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT71"/>
    <dbReference type="STRING" id="353152.Q5CT71"/>
    <dbReference type="GeneID" id="3373484"/>
    <dbReference type="KEGG" id="cpv:cgd2_4190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4190"/>
    <dbReference type="InParanoid" id="Q5CT71"/>
    <dbReference type="OMA" id="FEWEERI"/>
    <dbReference type="OrthoDB" id="2320933at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18026">
        <property type="entry name" value="DEXHc_POLQ-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000813">
        <property type="entry name" value="helicase POLQ-like isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048960">
        <property type="entry name" value="POLQ-like_helical"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF6">
        <property type="entry name" value="DNA-DIRECTED DNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21099">
        <property type="entry name" value="POLQ_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="149"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="455"/>
            <end position="613"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1154" mass="131087" checksum="CD9E65792392F9A1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT76</accession>
    <name>Q5CT76_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial import inner membrane translocase subunit tim17</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd2_4140</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Tim17/Tim22/Tim23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626593.1">
        <property type="nucleotide sequence ID" value="XM_626593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT76"/>
    <dbReference type="FunCoup" id="Q5CT76">
        <property type="interactions" value="186"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT76"/>
    <dbReference type="GeneID" id="3373692"/>
    <dbReference type="KEGG" id="cpv:cgd2_4140"/>
    <dbReference type="InParanoid" id="Q5CT76"/>
    <dbReference type="OMA" id="FDCTFQY"/>
    <dbReference type="OrthoDB" id="2261329at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485:SF0">
        <property type="entry name" value="AT05822P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10485">
        <property type="entry name" value="MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM-17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02466">
        <property type="entry name" value="Tim17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="37"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="81"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="187" mass="20928" checksum="3665C06C833E8A09" modified="2005-04-12" version="1" fragment="single">LEFYKYVFILSNLKYIYLQILSFIMSDFTREPFPGRVFEDLGGAFSMGCIGGFITSFFKGVKYSSTKREMFSSGMLFARKAAPSLGTSFAIWGGTFSCFDCLFAKLRGKEDHWNAIFSGTATGGLLAIRGGLKTSLKSAMVGGILLTIIESVSIGINRKTIQTPRQQFKEYQRFVQMSEERDKTSKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT80</accession>
    <name>Q5CT80_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RP-A, OB fold single strand binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_4080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626589.1">
        <property type="nucleotide sequence ID" value="XM_626589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT80"/>
    <dbReference type="STRING" id="353152.Q5CT80"/>
    <dbReference type="GeneID" id="3373489"/>
    <dbReference type="KEGG" id="cpv:cgd2_4080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4080"/>
    <dbReference type="InParanoid" id="Q5CT80"/>
    <dbReference type="OMA" id="CAEHEEY"/>
    <dbReference type="OrthoDB" id="343095at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd04478">
        <property type="entry name" value="RPA2_DBD_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="362" mass="40049" checksum="3632ADA2A6511F97" modified="2005-04-12" version="1">MNFGGNNKPFGGFGMDDLNESGGFMIDGNDSSMQNGNERKQSVGNEQKLAPLKVGMILRSYSNFVTLSRFQLFDKDINLFKLVGFVRNVEHDDYPQRLRFYLDDGSGLILIDWLVDNTGTKYKQDLVNSIHEGCFVKIFGELTLMVSEPSVRAFVVRPLVCTDEISLHDIDVASYIVRSMYGNTYDSGKVQLSDSNVIINKQGSMNYGGAGDSVKDSNQSIVSSMFNLSGQFGSNNNNNTNNKNEGNFNNYGGNNNFGNEQNISMNKPPIRVVSAIAPKSNQFNSGAGVQSNPLKLREIISSVLDQASNEGNPEMTIDGIFDSLLTRDVHATHDDIRNQLKNLVGEAKVYQTNPHTWRATGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTA1</accession>
    <name>Q5CTA1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_3840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626568.1">
        <property type="nucleotide sequence ID" value="XM_626568.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTA1"/>
    <dbReference type="GeneID" id="3373401"/>
    <dbReference type="KEGG" id="cpv:cgd2_3840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3840"/>
    <dbReference type="InParanoid" id="Q5CTA1"/>
    <dbReference type="OrthoDB" id="343339at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="359" mass="41859" checksum="001A7FBA5E5186FE" modified="2005-04-12" version="1">MYGIKIFQAEKVLPICGIIARRNTRVLTKFAIPVINREFNKRWFHFNQNRELISQNDSNSSLPLLLSIDKGKFYSDLDGNIKKNKLKDLLKNKYLGIINNNNNNNNNNNNNNRRNIKLGVSAGLISLLLYILSLIKERNENEKHIKSRFGPNIATKYIINVINDPKIEDSLKKLFKRVLTSLVKDDEFTKDWKMGIRHVIKECEDEIGENLTNVLKTKIVQDWLYSTTNEIVDYMSKAPDIISKTSSLFSDAFNHHIFTENSKKWLEEFIHNCVINNKKIIHSINHLLIRIFNTKDIQNNLSDLFKDVILNESTQDYISLAFWNVIRKSIIFPKNWFNGIKSTENSLKKLVNSKEDSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTE4</accession>
    <name>Q5CTE4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_3350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626525.1">
        <property type="nucleotide sequence ID" value="XM_626525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTE4"/>
    <dbReference type="GeneID" id="3373766"/>
    <dbReference type="KEGG" id="cpv:cgd2_3350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3350"/>
    <dbReference type="InParanoid" id="Q5CTE4"/>
    <dbReference type="OMA" id="SKCFVYP"/>
    <dbReference type="OrthoDB" id="341684at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="288" mass="32682" checksum="2F4E4148AC17965C" modified="2005-04-12" version="1">MGNQLVKLRADRAQDAQDVREWAFATFPGLETNLEAIFAYHCTDGVGLLDYETIEKISRHLIMNFGYTDLLLRFTTPNGTLDNRHVSNGLAILDVDIRKPITLDTFKNFVVCWLDRLIEAQDKDVENLNSALNNEQEKQKARILHAVAQWRERFKTIDDFHVFCDDVRDAKKVELDEVVADVYDMQERLNEQQLRLLQRQKEVEEVYANVQAEEAAIQEALSNAPTATQIISEEIAKTFKNNIQGDVTQIAYSSELTPFGAPVSAGASTSFKRNIPKARKSTKVLGMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTG2</accession>
    <name>Q5CTG2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626507.1">
        <property type="nucleotide sequence ID" value="XM_626507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTG2"/>
    <dbReference type="GeneID" id="3373562"/>
    <dbReference type="KEGG" id="cpv:cgd2_3130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3130"/>
    <dbReference type="InParanoid" id="Q5CTG2"/>
    <dbReference type="OrthoDB" id="340848at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="419" mass="48126" checksum="C7B9A9383A6DAA96" modified="2005-04-12" version="1">MNSIPNNDIEFDGMSNGNDSQLFASKEDKLLLKLPILITTTTTSTTTTSTRKSFTSKTSTSIPINNNNTKLPTTKGREKEENTDSDIGKHNHIQTITLALLESSFCEERKDNYKQITMALKEHISNILGIHIQDIVIDEIYAENSNKLFSGYEKCNLPNGKLKGIIFDLSIIKNILIDYPTYNDIERITLIENEFNNKYGKIILWKRNIDNINNEHNPFCQASLKTTNNIKFMCINNPIYCIHNNEYKCYTNPMGIDCFCYNDQSIYNHIQNNQYNITYPMTNECKTIISCTNDITLPIIPRCSTSPYSIGCPCNLNPYSKLCGCYINPFNPGCHCTYNPNSNDCKCLLNPEECKNENGLDIIDYEIIDRGPFDLKHGLRRFYKKHFRKSNSLPIFSNYHILQSLLIIFLNMMILYTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTH2</accession>
    <name>Q5CTH2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_3030</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626497.1">
        <property type="nucleotide sequence ID" value="XM_626497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTH2"/>
    <dbReference type="GeneID" id="3373571"/>
    <dbReference type="KEGG" id="cpv:cgd2_3030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3030"/>
    <dbReference type="InParanoid" id="Q5CTH2"/>
    <dbReference type="OMA" id="WKYINIG"/>
    <dbReference type="OrthoDB" id="340163at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254504" evidence="3">
        <location>
            <begin position="26"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="410"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="87"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="413"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="704" mass="81434" checksum="96D55041A32DCB00" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTH8</accession>
    <name>Q5CTH8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_2940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88717.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626491.1">
        <property type="nucleotide sequence ID" value="XM_626491.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTH8"/>
    <dbReference type="STRING" id="353152.Q5CTH8"/>
    <dbReference type="GeneID" id="3373461"/>
    <dbReference type="KEGG" id="cpv:cgd2_2940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2940"/>
    <dbReference type="InParanoid" id="Q5CTH8"/>
    <dbReference type="OrthoDB" id="342091at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="126"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="539"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88717.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1132" mass="120872" checksum="0B997F2B23FE87BA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTK0</accession>
    <name>Q5CTK0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">UDP N-acetylglucosamine transporter-like nucleotide sugar transporter with 10 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_2670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626469.1">
        <property type="nucleotide sequence ID" value="XM_626469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTK0"/>
    <dbReference type="FunCoup" id="Q5CTK0">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="GeneID" id="3373634"/>
    <dbReference type="KEGG" id="cpv:cgd2_2670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2670"/>
    <dbReference type="InParanoid" id="Q5CTK0"/>
    <dbReference type="OMA" id="KCYVIAS"/>
    <dbReference type="OrthoDB" id="408493at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015165">
        <property type="term" value="F:pyrimidine nucleotide-sugar transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007271">
        <property type="entry name" value="Nuc_sug_transpt"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00803">
        <property type="entry name" value="nst"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10231">
        <property type="entry name" value="NUCLEOTIDE-SUGAR TRANSMEMBRANE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04142">
        <property type="entry name" value="Nuc_sug_transp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005799">
        <property type="entry name" value="UDP-gal_transpt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="129"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="185"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="283"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="345"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="369"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="414" mass="46832" checksum="A7F196AD27FB8CC7" modified="2005-04-12" version="1">MKVEQNVITTEATRLLECEAFKERKMFEIYYSNGLYYLAIFKGRYNIQMRFLTLILMSVQCICVVLCMKLSVTYPASDGKQYLTPVAVVMVEILKLLTSLFMIFQISGGNSFKEFIYALKCEFLHDVRGNLLVVVPGILFLFQNNLTYIAIENLPASIYQVTAQLKVLTTALFSVVLLKRSLSTTRWFACFLLFVGVLLVQKTNIRNKGSINSFQLMIGFLASVTCSITSGLGSVIIEKVVKDPDDSKIVSSDIENSTKLDNLIDERPNDRVQYKSSVWGRNVILSLIGIFGGTPIAWITCKEKIIRDGVFQGFSWLTILVIFLNAYGGFIVVGVLKYSDSIMKCFFNALTIVIITILSWAFMGDNTPSIKFFIASTIVIIAISVYTFNKVFPDSFYTKFSRLFKFKNRNTESH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTL4</accession>
    <name>Q5CTL4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_2530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626455.1">
        <property type="nucleotide sequence ID" value="XM_626455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTL4"/>
    <dbReference type="GeneID" id="3373647"/>
    <dbReference type="KEGG" id="cpv:cgd2_2530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2530"/>
    <dbReference type="InParanoid" id="Q5CTL4"/>
    <dbReference type="OrthoDB" id="343760at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254509" evidence="2">
        <location>
            <begin position="25"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="180"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="342" mass="38969" checksum="EE27400199451450" modified="2005-04-12" version="1">MQINYLIFSVFSALLLGLNSPVYAITTESNEYVANTKSKSRNRLRRFLDSLNKVELKLPKITRKNVISEYTVEDLVSKLREIEKTRSNTKNPFKKIRCLIQESNIKKKISSLLKEKSEEEKFEKFEEEFPMDYSPKALSEEGSISPYIPVVVEDYKDVEVASGASIRNEGIQDEIKYLTSEDTDQSTSGELDDLAHPITSETGNENEGTEDSVTEDFEKKEVVEDNLEDYQAKDVDGESQSNENGQQTDSDLQENADRGEKDNIQSKARLANIFKRKKLTASEKLERLMSLKKDIESRISSSKSKLLRRVLEMKLKRVNHKISKITDAAVDTVTESGEIDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTM5</accession>
    <name>Q5CTM5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SSM4 like RING finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd2_2410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_626444.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTM5"/>
    <dbReference type="STRING" id="353152.Q5CTM5"/>
    <dbReference type="GeneID" id="3373500"/>
    <dbReference type="KEGG" id="cpv:cgd2_2410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2410"/>
    <dbReference type="InParanoid" id="Q5CTM5"/>
    <dbReference type="OMA" id="ITCYDQR"/>
    <dbReference type="OrthoDB" id="20664at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46065:SF3">
        <property type="entry name" value="FI20425P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="6" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="88"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="domain" description="RING-CH-type" evidence="11">
        <location>
            <begin position="7"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="155" mass="18308" checksum="82FD67AB566B40AF" modified="2005-04-12" version="1">MYMEEGFLNIYNKECRFCFGVETDHSPLITPCECKGTQAYIHLNCLYKWQRLQINRPWSSRFCSVCLHPYSIPRNTHFVFFQGSRIKLFYCGIFSTYIKLFFAVFAIANLQVFSDLSPHLGNLSFFSILGFIFSFFLYYNSRKRIFINNLQADSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTM6</accession>
    <name>Q5CTM6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_2390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626443.1">
        <property type="nucleotide sequence ID" value="XM_626443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTM6"/>
    <dbReference type="GeneID" id="3373504"/>
    <dbReference type="KEGG" id="cpv:cgd2_2390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2390"/>
    <dbReference type="InParanoid" id="Q5CTM6"/>
    <dbReference type="OMA" id="IEPWILL"/>
    <dbReference type="OrthoDB" id="343533at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="57"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="294"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="336" mass="38325" checksum="8895F3CBA18FD329" modified="2005-04-12" version="1">MEKSKASKLTPSNALTTFKERVLANNTIFSHTLMIAQSIVQALNLTLIGNIGLEPWILLALRCIGGLVFLSTISIFSLIREPLPTDFNTKVLSYCFSIGQISVMGIYLLFGSTDDRFNDNFILLAPALVIFGIFYDKNIYLNKKNSLLKRFIYLFIIFWSVIASTRSIINFIQIKNSWAFFIYLIFFTSIFLICKIIFYLTVIKINKNKIRPLEISATSLLNVSKIGIPIGVLVHTWRMNKLLPRREYKLFLFDLARCGRVSALKVIISSFISFGIIFPLQIITIPNISFFEYALYSIFPSILFSHDYITIGFISVTIFIILNKSGDDKVSEKDSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTS6</accession>
    <name>Q5CTS6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RSC8 ortholog with a swirm domain, ZZ finger and Myb</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_1740</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626393.1">
        <property type="nucleotide sequence ID" value="XM_626393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTS6"/>
    <dbReference type="STRING" id="353152.Q5CTS6"/>
    <dbReference type="GeneID" id="3373743"/>
    <dbReference type="KEGG" id="cpv:cgd2_1740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1740"/>
    <dbReference type="InParanoid" id="Q5CTS6"/>
    <dbReference type="OMA" id="QQFNEME"/>
    <dbReference type="OrthoDB" id="118550at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000014">
        <property type="entry name" value="SWI/SNF complex subunit SMARCC2 isoform C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032451">
        <property type="entry name" value="SMARCC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007526">
        <property type="entry name" value="SWIRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802:SF41">
        <property type="entry name" value="BRAHMA ASSOCIATED PROTEIN 155 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12802">
        <property type="entry name" value="SWI/SNF COMPLEX-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04433">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16495">
        <property type="entry name" value="SWIRM-assoc_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50934">
        <property type="entry name" value="SWIRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="SWIRM" evidence="7">
        <location>
            <begin position="286"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="536"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="540"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="66"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="802" mass="91108" checksum="3DD91BFCCE0DA002" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTV1</accession>
    <name>Q5CTV1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator superfamily protein, putative, 12 transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_1450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626368.1">
        <property type="nucleotide sequence ID" value="XM_626368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTV1"/>
    <dbReference type="STRING" id="353152.Q5CTV1"/>
    <dbReference type="GeneID" id="3373727"/>
    <dbReference type="KEGG" id="cpv:cgd2_1450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1450"/>
    <dbReference type="InParanoid" id="Q5CTV1"/>
    <dbReference type="OMA" id="DYMISEM"/>
    <dbReference type="OrthoDB" id="6770063at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF9">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="130"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="189"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="342"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="376"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="440"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="487"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="527"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="65"/>
            <end position="541"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="574" mass="64308" checksum="1825B71337FDC8E8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTX7</accession>
    <name>Q5CTX7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit L</fullName>
            <shortName evidence="4">eIF3l</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_1160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626342.1">
        <property type="nucleotide sequence ID" value="XM_626342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTX7"/>
    <dbReference type="FunCoup" id="Q5CTX7">
        <property type="interactions" value="494"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTX7"/>
    <dbReference type="GeneID" id="3373587"/>
    <dbReference type="KEGG" id="cpv:cgd2_1160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1160"/>
    <dbReference type="InParanoid" id="Q5CTX7"/>
    <dbReference type="OMA" id="AGWFIRN"/>
    <dbReference type="OrthoDB" id="15082at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03011">
        <property type="entry name" value="eIF3l"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019382">
        <property type="entry name" value="eIF3l"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13242:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10255">
        <property type="entry name" value="Paf67"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="550"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="551"/>
            <end position="571"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="673" mass="77540" checksum="2D39C2AF37EEA03B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU36</accession>
    <name>Q5CU36_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_4360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626978.1">
        <property type="nucleotide sequence ID" value="XM_626978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU36"/>
    <dbReference type="GeneID" id="3374052"/>
    <dbReference type="KEGG" id="cpv:cgd3_4360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4360"/>
    <dbReference type="InParanoid" id="Q5CU36"/>
    <dbReference type="OrthoDB" id="342776at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253853" evidence="2">
        <location>
            <begin position="23"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="425" mass="48952" checksum="1D41DE08B34754D4" modified="2005-04-12" version="1">MISKILFLSILILIYLSIFVDSASKDPPRKASEVLESSPGLSTQSENKDAHSQETTSLGTTPSNTATNLQSKTIQLIVSKKPVDISEPLADLIAKFLVENAEILVILEFETRSLCFNNIYLSKFWSSLNKITSNEHTLIKGLVNFWDEENDSVPNKIVEYMVRSHKDYKRVILKDYRRLKVSRHKLMLNNLNIFKCSNLKNAFALLILIFEGNDEDTFSVLLLFLLICSARIVEGNSFKEKFEFVIRNKKKSASSISLIGGRNIESRIKKFHEAMTSSRILLSSVDPVLFPLDMDRISIEEFGFRFCTALMELALLERLDLSSKYLLFFFTSRMTQTSEVLLSLDLYNIIAKRNTNPKKILAIFLYDADTFNEVRKKTLTFHNLDLINLKNNLEECFKMKEENSLLREIKIETDYQRKTRKKKGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU90</accession>
    <name>Q5CU90_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Hsp90</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_3770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the heat shock protein 90 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626924.1">
        <property type="nucleotide sequence ID" value="XM_626924.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU90"/>
    <dbReference type="SMR" id="Q5CU90"/>
    <dbReference type="FunCoup" id="Q5CU90">
        <property type="interactions" value="281"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU90"/>
    <dbReference type="GeneID" id="3373931"/>
    <dbReference type="KEGG" id="cpv:cgd3_3770"/>
    <dbReference type="InParanoid" id="Q5CU90"/>
    <dbReference type="OMA" id="MRRMKEM"/>
    <dbReference type="OrthoDB" id="28737at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16927">
        <property type="entry name" value="HATPase_Hsp90-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.790:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.80:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11260:FF:000001">
        <property type="entry name" value="Heat shock protein 90 alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000001">
        <property type="entry name" value="Heat shock protein HSP 90-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.790">
        <property type="entry name" value="Heat shock protein 90, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00505">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003594">
        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019805">
        <property type="entry name" value="Heat_shock_protein_90_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037196">
        <property type="entry name" value="HSP90_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001404">
        <property type="entry name" value="Hsp90_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020575">
        <property type="entry name" value="Hsp90_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003555">
        <property type="entry name" value="PRK05218.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11528">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00183">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002583">
        <property type="entry name" value="Hsp90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00775">
        <property type="entry name" value="HEATSHOCK90"/>
    </dbReference>
    <dbReference type="SMART" id="SM00387">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110942">
        <property type="entry name" value="HSP90 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00298">
        <property type="entry name" value="HSP90"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histidine kinase/HSP90-like ATPase" evidence="9">
        <location>
            <begin position="37"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="223"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="691"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="239"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="90"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="95"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="103"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="110"/>
            <end position="111"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="130"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="384"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR002583-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="711" mass="82354" checksum="39C265ECFDE8BCA0" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUD1</accession>
    <name>Q5CUD1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase alpha subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd3_3320</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626883.1">
        <property type="nucleotide sequence ID" value="XM_626883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUD1"/>
    <dbReference type="FunCoup" id="Q5CUD1">
        <property type="interactions" value="517"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUD1"/>
    <dbReference type="GeneID" id="3373771"/>
    <dbReference type="KEGG" id="cpv:cgd3_3320"/>
    <dbReference type="InParanoid" id="Q5CUD1"/>
    <dbReference type="OMA" id="QIEGWVM"/>
    <dbReference type="OrthoDB" id="238316at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00496">
        <property type="entry name" value="PheRS_alpha_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000178">
        <property type="entry name" value="Phenylalanyl-tRNA synthetase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004529">
        <property type="entry name" value="Phe-tRNA-synth_IIc_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002319">
        <property type="entry name" value="Phenylalanyl-tRNA_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040724">
        <property type="entry name" value="PheRS_DBD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040725">
        <property type="entry name" value="PheRS_DBD3"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00468">
        <property type="entry name" value="pheS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003210">
        <property type="entry name" value="PRK04172.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538:SF40">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11538">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18552">
        <property type="entry name" value="PheRS_DBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18553">
        <property type="entry name" value="PheRS_DBD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01409">
        <property type="entry name" value="tRNA-synt_2d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="378"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00030612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK89256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="514" mass="59095" checksum="97ABCF165B2E3DAF" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUD4</accession>
    <name>Q5CUD4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_3290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626880.1">
        <property type="nucleotide sequence ID" value="XM_626880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUD4"/>
    <dbReference type="GeneID" id="3373871"/>
    <dbReference type="KEGG" id="cpv:cgd3_3290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3290"/>
    <dbReference type="InParanoid" id="Q5CUD4"/>
    <dbReference type="OMA" id="ANMRHYL"/>
    <dbReference type="OrthoDB" id="342099at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="88"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="167" mass="19647" checksum="7517C42BAFE54806" modified="2005-04-12" version="1">MRSYIKIIALFFSIIAFNINFEYDLSLNLLSNHAYSFVRTKKNAWDIVNENHEIFNSPGRRANGELSLSSYKWNISYDQPFSSQISQVILVILVIVLLICVILSLICCRYSVPKEEDFTKKEDGIYYFENEKRPEEFALIYNKNAQNRRYILTGETPKNIEYCEDQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUH3</accession>
    <name>Q5CUH3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_2830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626841.1">
        <property type="nucleotide sequence ID" value="XM_626841.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUH3"/>
    <dbReference type="GeneID" id="3373957"/>
    <dbReference type="KEGG" id="cpv:cgd3_2830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2830"/>
    <dbReference type="InParanoid" id="Q5CUH3"/>
    <dbReference type="OMA" id="INLPREF"/>
    <dbReference type="OrthoDB" id="343087at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="294" mass="33712" checksum="0DECF9051DAFA34D" modified="2005-04-12" version="1">MQLRSKLNHNVADYFRKSLQVSSANLSDSNMPFPYKHEFFSGLIKLPFLSSEPEYINFPISQASIQEYLTTLYEFTHNLQINMIPRHNAGFSNDSIKAEDAVENPSRKNHISSDDLAIIDEEIIGVYYGTKANECDITSQSVCMERGTIETDDQVVKLMHPIKQNVTAVSILDIIPLDMNYCSTFQVMLDSQEEGMDTILELDEGWNHPTTRFSLYNKIENKLYKYVRDYSSNLPKEYTKSYIISLPRHFLECKEESKSSETSGSKAYLISTKSPKLLLSKVSSMKRKPKIKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUK5</accession>
    <name>Q5CUK5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_2480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626809.1">
        <property type="nucleotide sequence ID" value="XM_626809.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUK5"/>
    <dbReference type="GeneID" id="3373911"/>
    <dbReference type="KEGG" id="cpv:cgd3_2480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2480"/>
    <dbReference type="InParanoid" id="Q5CUK5"/>
    <dbReference type="OMA" id="IHEIAKY"/>
    <dbReference type="OrthoDB" id="339968at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="474" mass="54396" checksum="AEC4C019DF5CB52B" modified="2005-04-12" version="1">MSQDLICRKIAHLKVDAEASIRNSSSRIERILNDGLPIFSDEVGSFSSNAEKFYISTSNREMENTTIGAKNYLNNAKWDLVNKYYINVLKNLDSLTNIIFCIQKNYFDNIQYINISQSYNMASSIDNITTRSLRINEASKGELLISLYRRLYILRPFIEKINNEILRIPDHIITHKCALSTLNELLPIWKISINSQAKNESQCLYNRENKLSSVICLQLPLENVFFKQGSFVSRPMAQIDNNCLFNDVLVTLTFSKNKFNPYGGKYNLRASLKLPEFTSYLINNNYQLYVKTKPSDSESKNVTSSTLPQVDFPSCIKSALAKQIHSTLHRVHWALIDRLIFHTIVQQVVNAQKDSPEAIYINELSSERVIFSINEANPSISSHDNSSLEVKNISVSYKPISVENFFLSNDELNALKLLRESFLEIWRNSIKLSTDNLLENQMCVIKLSKYSNKLLERWIHKLAKKCINISATSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUP8</accession>
    <name>Q5CUP8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Histone deacetylase complex subunit SAP30 Sin3 binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626766.1">
        <property type="nucleotide sequence ID" value="XM_626766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUP8"/>
    <dbReference type="GeneID" id="3374051"/>
    <dbReference type="KEGG" id="cpv:cgd3_1960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1960"/>
    <dbReference type="InParanoid" id="Q5CUP8"/>
    <dbReference type="OrthoDB" id="339605at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038291">
        <property type="entry name" value="SAP30_C_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="284" mass="31813" checksum="C48E332D13D94363" modified="2005-04-12" version="1">MEGEGLGMANTTDLACPMNLEEEVKMHENSNQEEAMVKGQVVGKENGTITVETDLMEKLKSQHIVEEESNKSVGKTLEEAVCTENSNNSNSNVESTLKGEKQDENKENIEMKDVTSPENKGKSKHLSKIDFSVFEEGFYRRYKSFFHDRQADEIDLTQDKATISKKINEHFSNFEINPVDVIRTFLVLRKNSEHSHGHFVMSPAQSPEPNIHPSSEGNTRGRRCANKDMGGVSNDANNAETNANGVNYKGEYKSENSSIVDNHTEIGVSTRNSRKGRVSNRGRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUQ0</accession>
    <name>Q5CUQ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626764.1">
        <property type="nucleotide sequence ID" value="XM_626764.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUQ0"/>
    <dbReference type="GeneID" id="3374147"/>
    <dbReference type="KEGG" id="cpv:cgd3_1930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1930"/>
    <dbReference type="InParanoid" id="Q5CUQ0"/>
    <dbReference type="OrthoDB" id="343003at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="328" mass="37709" checksum="2FD692B1428AF1A5" modified="2005-04-12" version="1">MMASRKQEEVLVIYIKSVIQLICSLCVIIIIFNKDWISGQNTISESFVVGFLDELCIRSSVLPLSRQSWKESDVGKSFNLNESEKSPFQARKSNSDIIKNKLGKTLDSEIVNSSILRHKKLSHRHKLKLDVEEVNNLFQQKLLGENGNITSLKGNESKLNNGESKKSGLYFSSFDQVQYCISHKSNKLVKDWYIHPNYLSYLVLFIVIVSVIFSLNLIKMKNKWSSYELLIPILDFLVFSISLLNLAQILHVLTPLLTYLQKHNFMAFFSTNFFMLSGSIGGFFIVFSLSIGIIHYRYEAFTNLKRFEDQIENIQSFSSFIHLISNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUR6</accession>
    <name>Q5CUR6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626748.1">
        <property type="nucleotide sequence ID" value="XM_626748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUR6"/>
    <dbReference type="SMR" id="Q5CUR6"/>
    <dbReference type="GeneID" id="3374161"/>
    <dbReference type="KEGG" id="cpv:cgd3_1760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1760"/>
    <dbReference type="InParanoid" id="Q5CUR6"/>
    <dbReference type="OrthoDB" id="343503at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253869" evidence="2">
        <location>
            <begin position="26"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="294" mass="33360" checksum="32C2B50C74D5F7F3" modified="2005-04-12" version="1">MASFNYIFTVGFVLISIYLNASNDAIRNEKIKSNEFSFLNAQGPSYSLSEHPSPFKTTIGPILFAGKPEGVSLEEYLSRFGYNGRKDDLQPACTKQQVKALLKELKKILRDYYPLVGKNNYFRKLSYTAAQNSLEDIDITRYLSSTRPLFTRTESILISLLERLFKCILSRKIKKYSKSSGYEVSLLLYNKSMRTISKDLLKVLKSVESSLGEEYPKCLRTSTGASLVECKALGESLDVCKEHIRHQKEAKEGKYKEEKVLKGILKSPHSDHSRSRPTSGQKHVKFEELASVDV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUT5</accession>
    <name>Q5CUT5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec14 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626729.1">
        <property type="nucleotide sequence ID" value="XM_626729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUT5"/>
    <dbReference type="GeneID" id="3374026"/>
    <dbReference type="KEGG" id="cpv:cgd3_1550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1550"/>
    <dbReference type="InParanoid" id="Q5CUT5"/>
    <dbReference type="OMA" id="LRICNEW"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46818:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_125, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46818">
        <property type="entry name" value="DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="144"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="437"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="437"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="460"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="817" mass="95222" checksum="E567ECF2EA85F20C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUU2</accession>
    <name>Q5CUU2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Dual specificity phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_1470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626722.1">
        <property type="nucleotide sequence ID" value="XM_626722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUU2"/>
    <dbReference type="STRING" id="353152.Q5CUU2"/>
    <dbReference type="GeneID" id="3373975"/>
    <dbReference type="KEGG" id="cpv:cgd3_1470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1470"/>
    <dbReference type="InParanoid" id="Q5CUU2"/>
    <dbReference type="OMA" id="VKCSTIW"/>
    <dbReference type="OrthoDB" id="10252009at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14498">
        <property type="entry name" value="DSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000340">
        <property type="entry name" value="Dual-sp_phosphatase_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020422">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948:SF2">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45948">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE DDB_G0269404-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00782">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01908">
        <property type="entry name" value="ADSPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00195">
        <property type="entry name" value="DSPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50054">
        <property type="entry name" value="TYR_PHOSPHATASE_DUAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tyrosine-protein phosphatase" evidence="6">
        <location>
            <begin position="132"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="7">
        <location>
            <begin position="196"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="314" mass="35642" checksum="3D9B379F0E370955" modified="2005-04-12" version="1">MEALKRLIDKRSERMAVVENISGSTESELILPERVNFYFAALRILHQLKRKTPEPMKGMQIQETISLICSLDQVISLYGALVTSPKSTIEDYEEKVESNMRTIISSINRLGFRDILQKEVQYSNKENLDLHRAQRIIPGIFLGGSTVANDLKKLKDLGITHIVCCLQGACKFPNEFLYLNIPIYDTPFEDISKYFSSSFDFIHNALSQSTVERPNNVYIHCAAGISRAPTICTAFLMRELGISSLQALNLIKLSRPYVAPNPGFLNQLYNYQLFLTSAKVCQKRQQISNSNQTQIQVQGVPYQTNLKRNVGRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUX7</accession>
    <name>Q5CUX7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Rrp9p/U3-55K-family snoRNP-associated protein with several WD40 repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_1090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626687.1">
        <property type="nucleotide sequence ID" value="XM_626687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUX7"/>
    <dbReference type="STRING" id="353152.Q5CUX7"/>
    <dbReference type="GeneID" id="3373841"/>
    <dbReference type="KEGG" id="cpv:cgd3_1090"/>
    <dbReference type="InParanoid" id="Q5CUX7"/>
    <dbReference type="OMA" id="MPEQARM"/>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039241">
        <property type="entry name" value="Rrp9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19865:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-INTERACTING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="133"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="183"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="225"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="60"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="457" mass="52041" checksum="0A501D7B054E8A81" modified="2005-04-12" version="1" fragment="single">IMKRKFQQIKKNQGKKKNENEEIVSSSDDESFLNNKKSVDYQDHKNSHFIGRTLGSNVESDYENGEEEDDDDEEDTFFENDDERRVSLAKKYLKKIDALDDDDIKKSLNILEGKISQRDIADSFNITSDSTFYKGHKLSPTCVTLDKDGRTAYTGGKDCAIIKWDLETGKKIIFPGSRKDFECGGHFEQVKTICYHKETNLICSGGEDKVIRIWDHRVQKCIEKFHGHTNTITGIVSEPNSDIDQIISVSFDKSLKVWSLKSRSHMNTYYGHTNKITSCDIILKDRPFTGSEDNTSRLWKLSADSHLIFYPSNNNNNNDLSKNIESPIDSVSCLNNVNYITGQQDGTIHIWSQFKKKPLFTSNDLHKGGIYSIKSIPFTDLFFTGSDDQEIKAWKWSNQNNNISLINSIKISGFVNDISVSDKLIVAAIGQEHRLGRWNSIKESKNGLLVVPISYNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUY0</accession>
    <name>Q5CUY0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U1 like C2H2 zinc finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_1060</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626684.1">
        <property type="nucleotide sequence ID" value="XM_626684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUY0"/>
    <dbReference type="FunCoup" id="Q5CUY0">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUY0"/>
    <dbReference type="GeneID" id="3374172"/>
    <dbReference type="KEGG" id="cpv:cgd3_1060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1060"/>
    <dbReference type="InParanoid" id="Q5CUY0"/>
    <dbReference type="OMA" id="CATCECT"/>
    <dbReference type="OrthoDB" id="30343at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040107">
        <property type="entry name" value="Snu23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45986:SF1">
        <property type="entry name" value="ZINC FINGER MATRIN-TYPE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="85"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="18"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="151"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="165"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="186"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="198" mass="22945" checksum="826E0B477A1C62B1" modified="2005-04-12" version="1">MSGVNSLGRKVWDKEFYSKSKEERDRIRSLENAEHEKKLEKKEEISEEDAKKMREMYLDISKNVGLSKSHTSGDDVRKNISGYWCEVCNLGFNDSHSWIRHLNSQSHNQKMGTSLYVEKKSLESVKRRLSELIHDYDHGLGIFSKHNKNESKNGVYGQGIKGGNKVKDKDRVSSEEENMSEDETKNQMLQYNFPSSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV63</accession>
    <name>Q5CV63_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">tRNA pseudouridine synthase</fullName>
            <ecNumber evidence="6">5.4.99.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_5280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>uridine(38/39/40) in tRNA = pseudouridine(38/39/40) in tRNA</text>
            <dbReference type="Rhea" id="RHEA:22376"/>
            <dbReference type="Rhea" id="RHEA-COMP:10085"/>
            <dbReference type="Rhea" id="RHEA-COMP:10087"/>
            <dbReference type="ChEBI" id="CHEBI:65314"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="EC" id="5.4.99.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.12" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627406.1">
        <property type="nucleotide sequence ID" value="XM_627406.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV63"/>
    <dbReference type="FunCoup" id="Q5CV63">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV63"/>
    <dbReference type="GeneID" id="3374665"/>
    <dbReference type="KEGG" id="cpv:cgd8_5280"/>
    <dbReference type="InParanoid" id="Q5CV63"/>
    <dbReference type="OMA" id="MYIFKIA"/>
    <dbReference type="OrthoDB" id="25767at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160147">
        <property type="term" value="F:tRNA pseudouridine(38-40) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00071">
        <property type="entry name" value="hisT_truA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF5">
        <property type="entry name" value="TRNA PSEUDOURIDINE(38_39) SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001430">
        <property type="entry name" value="tRNA_psdUrid_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="7">
        <location>
            <begin position="138"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR001430-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="283" mass="33167" checksum="B46A41429AA5D935" modified="2005-04-12" version="1" fragment="single">LIFFQGIAFQKDDKIPTIEGEIYKALLQLRLIKDIDSCDLVRCGRTDRGVHSAGNYISVNLRTRAKNLEPYNYMEMLNGVLPWDIRVIGYCEVRPDFSARFDCEYRLYKYFFPLNHERTKISKFPKIPPEQVPLMNVAAKQFLGTHDYRRFCKMDLKNRKNQTYIRTIYEFDINFVDENRTFAVATIKGSAFLWHQVRLMMGILFEIGQQKFNPEVITQMLTDVEQKNIAELSFQMATELGLVLWDCVFKEYDIQCNTNSLKTFLDESESLKLKASLYSFIGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV70</accession>
    <name>Q5CV70_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_5210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627399.1">
        <property type="nucleotide sequence ID" value="XM_627399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV70"/>
    <dbReference type="GeneID" id="3374221"/>
    <dbReference type="KEGG" id="cpv:cgd8_5210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5210"/>
    <dbReference type="InParanoid" id="Q5CV70"/>
    <dbReference type="OMA" id="CCNITIH"/>
    <dbReference type="OrthoDB" id="343366at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="55"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="711"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="584"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="731"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1107" mass="127345" checksum="4BAD9AE836ECB2AF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV96</accession>
    <name>Q5CV96_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PAN2 family 3'5' exonuclease, UBC hydrolase (Inactive) plus nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_4910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627373.1">
        <property type="nucleotide sequence ID" value="XM_627373.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV96"/>
    <dbReference type="GeneID" id="3374376"/>
    <dbReference type="KEGG" id="cpv:cgd8_4910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4910"/>
    <dbReference type="InParanoid" id="Q5CV96"/>
    <dbReference type="OMA" id="VSECEME"/>
    <dbReference type="OrthoDB" id="8191639at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06143">
        <property type="entry name" value="PAN2_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050785">
        <property type="entry name" value="PAN2-PAN3_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028881">
        <property type="entry name" value="PAN2_UCH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013520">
        <property type="entry name" value="Ribonucl_H"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728">
        <property type="entry name" value="DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15728:SF0">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX CATALYTIC SUBUNIT PAN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00929">
        <property type="entry name" value="RNase_T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13423">
        <property type="entry name" value="UCH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00479">
        <property type="entry name" value="EXOIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exonuclease" evidence="2">
        <location>
            <begin position="1706"/>
            <end position="1904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="515"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="548"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="773"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="905"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="946"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1554"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="551"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="946"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1563"/>
            <end position="1575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1582"/>
            <end position="1591"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1936" mass="213019" checksum="8DBFAA14B93C5CD5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVJ6</accession>
    <name>Q5CVJ6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">AATF leucine zipper-containing domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627273.1">
        <property type="nucleotide sequence ID" value="XM_627273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVJ6"/>
    <dbReference type="GeneID" id="3374285"/>
    <dbReference type="KEGG" id="cpv:cgd8_3810"/>
    <dbReference type="InParanoid" id="Q5CVJ6"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025160">
        <property type="entry name" value="AATF"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13339">
        <property type="entry name" value="AATF-Che1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AATF leucine zipper-containing" evidence="2">
        <location>
            <begin position="140"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="282" mass="33344" checksum="8CF4F664D80ACD20" modified="2005-04-12" version="1">MDFYDDEFYDRKNQSGSEIDQEETPDISEFSKNDGRLRFRANFNLPKKYAGEKISLSDFKEMRDREISTRDENSKFEEAAYDYSINDITGFDNINEEYSDFKNNIQLSDSISRKVDKYKELEANFSIVDNTKIMDKMIYDKERGENVKNQRKIWSDILAIRIFIQNALKLCNQLPPTGLISSLNEDSKTKLDEIRREILDLTLMNQELQMHLNRKNKRLSSTILNDSAKFGIYSRLNSKSSNKRIKAELKFWDKYNPVLDNTFEWCIDVCDEWKKNTQIEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVP7</accession>
    <name>Q5CVP7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Importin alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_3260</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the importin alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627222.1">
        <property type="nucleotide sequence ID" value="XM_627222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVP7"/>
    <dbReference type="FunCoup" id="Q5CVP7">
        <property type="interactions" value="260"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVP7"/>
    <dbReference type="GeneID" id="3374337"/>
    <dbReference type="KEGG" id="cpv:cgd8_3260"/>
    <dbReference type="InParanoid" id="Q5CVP7"/>
    <dbReference type="OMA" id="EMIQMLY"/>
    <dbReference type="OrthoDB" id="29145at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061608">
        <property type="term" value="F:nuclear import signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000009">
        <property type="entry name" value="Importin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.690">
        <property type="entry name" value="Importin-alpha, importin-beta-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032413">
        <property type="entry name" value="Arm_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000225">
        <property type="entry name" value="Armadillo"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002652">
        <property type="entry name" value="Importin-a_IBB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036975">
        <property type="entry name" value="Importin-a_IBB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024931">
        <property type="entry name" value="Importin_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23316">
        <property type="entry name" value="IMPORTIN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00514">
        <property type="entry name" value="Arm"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16186">
        <property type="entry name" value="Arm_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01749">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005673">
        <property type="entry name" value="Importin_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00185">
        <property type="entry name" value="ARM"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50176">
        <property type="entry name" value="ARM_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51214">
        <property type="entry name" value="IBB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IBB" evidence="8">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="116"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="repeat" description="ARM" evidence="5">
        <location>
            <begin position="159"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="13"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="13"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00259"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="552" mass="61553" checksum="CC9103683B46A01E" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVQ7</accession>
    <name>Q5CVQ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627212.1">
        <property type="nucleotide sequence ID" value="XM_627212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVQ7"/>
    <dbReference type="STRING" id="353152.Q5CVQ7"/>
    <dbReference type="GeneID" id="3374336"/>
    <dbReference type="KEGG" id="cpv:cgd8_3150"/>
    <dbReference type="InParanoid" id="Q5CVQ7"/>
    <dbReference type="OMA" id="WKLIQHE"/>
    <dbReference type="OrthoDB" id="427886at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014810">
        <property type="entry name" value="Fcf2_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08698">
        <property type="entry name" value="Fcf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Fcf2 pre-rRNA processing C-terminal" evidence="1">
        <location>
            <begin position="67"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="193" mass="22599" checksum="7B2E7912862EDB4D" modified="2005-04-12" version="1" fragment="single">YAKAFGKFIILNVKRSYNSFLIKGIIEIGKHKLIFDKQSAVPRYKLESDLVCSFTNNLETGEFKSNKKPNLSSWHNFHDHEKTEQEKFELLALQLRNSTAPGRFYKSEHLTKKQIKFNFGVVIDGNKMKTGLSDDSSTYRSNKKISGISLLHELVNNSETQRWTNKKYSEIQKTKLKGGKKWYRKQVLKRNRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVS5</accession>
    <name>Q5CVS5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Replication factor C like AAA ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_2940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627194.1">
        <property type="nucleotide sequence ID" value="XM_627194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVS5"/>
    <dbReference type="FunCoup" id="Q5CVS5">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVS5"/>
    <dbReference type="GeneID" id="3374333"/>
    <dbReference type="KEGG" id="cpv:cgd8_2940"/>
    <dbReference type="InParanoid" id="Q5CVS5"/>
    <dbReference type="OMA" id="GCQSGSF"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000952">
        <property type="entry name" value="Replication factor C subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000032">
        <property type="entry name" value="Replication factor C subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF20">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="39"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="335" mass="37401" checksum="EE9A9A318F5FE171" modified="2005-04-12" version="1" fragment="single">SSTMSSNLWVEKYRPGNVLDISHHKDVVSMLSHVLKNGNMPHLLFHGPPGTGKTSAVLALSRELFGPNEYKNRILELNASDERGISVVRDKIKSWTRQVVQCNKTHEITGNLLPSWKIVILDEAEMMTADAQSALRRIIEVSSKNTRFVIICNYISKIIEPLASRCAKFRFQPISANSQIERLKYICSQEDVSYEDGVLETIVNLSQGDLRRGINILQSASELFGKDKRISMSSILDVSGVPPIKIIERIINSCKILGVESILIETAKLINEGWSVELIFKGLAEFIIMCDKIDDSKKAFLMLRISEADASVIDGSNEYLTLLNVCSSVQTIFAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVW2</accession>
    <name>Q5CVW2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_2570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627157.1">
        <property type="nucleotide sequence ID" value="XM_627157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVW2"/>
    <dbReference type="GeneID" id="3374573"/>
    <dbReference type="KEGG" id="cpv:cgd8_2570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2570"/>
    <dbReference type="InParanoid" id="Q5CVW2"/>
    <dbReference type="OMA" id="QNDKRIW"/>
    <dbReference type="OrthoDB" id="341680at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="405" mass="46176" checksum="319852D6AC30F8CB" modified="2005-04-12" version="1">MSILIVFDIDFNSEHSILRLEYFKDALKRLFLDDEFNREYSECLISVYFVLDEMKRELVFANHRFKEVSWYPIGSCSLVPSLTIIDMLMEQITSSNIELKTEQDSFPIKSEVQNSINQQEIRPIPDCFSDFLKEGAIIERSELQNGTDNSFGAPGPNNINWTEEHQNIGKERQLLVIWLMDSSSCLKRLDNGGFPRFQDISESSLTPNVEVKYFLLNYGGDHQDQNRLSKVYLSEAQVEVVSLLPLCSADKILKDFICNEINSFYYSEKYVSIFSPDSPPTDLECFNDLSVIGFNLYPSLAKFPLFIQDTLKVLTLPCSSTFIGIISIAKYQPLPVLTRRLIELNNSSKGKEMAIQALILALHKEKFAMALELNPNWFALLVSIVIGSNIHLAMDILPPGYVITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVW3</accession>
    <name>Q5CVW3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">cgd8_2560</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the HRD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89697.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627156.1">
        <property type="nucleotide sequence ID" value="XM_627156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVW3"/>
    <dbReference type="FunCoup" id="Q5CVW3">
        <property type="interactions" value="181"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVW3"/>
    <dbReference type="GeneID" id="3374394"/>
    <dbReference type="KEGG" id="cpv:cgd8_2560"/>
    <dbReference type="InParanoid" id="Q5CVW3"/>
    <dbReference type="OMA" id="ANLTMFT"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16479">
        <property type="entry name" value="RING-H2_synoviolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050731">
        <property type="entry name" value="HRD1_E3_ubiq-ligases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057992">
        <property type="entry name" value="TPR_SYVN1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058051">
        <property type="entry name" value="Znf_RING_synoviolin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763:SF184">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SYNOVIOLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22763">
        <property type="entry name" value="RING ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25563">
        <property type="entry name" value="TPR_SYVN1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="14 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 17 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 15" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="95"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="155"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="190"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="256"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="18">
        <location>
            <begin position="337"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="386"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="429"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAK89697.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="637" mass="72818" checksum="7686A856C66A6F8F" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW16</accession>
    <name>Q5CW16_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dynamin like TRAFAC class GTpase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_1990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627103.1">
        <property type="nucleotide sequence ID" value="XM_627103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW16"/>
    <dbReference type="STRING" id="353152.Q5CW16"/>
    <dbReference type="GeneID" id="3374493"/>
    <dbReference type="KEGG" id="cpv:cgd8_1990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1990"/>
    <dbReference type="InParanoid" id="Q5CW16"/>
    <dbReference type="OMA" id="HYNIIDN"/>
    <dbReference type="OrthoDB" id="415706at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF233">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_59, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin N-terminal" evidence="2">
        <location>
            <begin position="61"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="257"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="966" mass="112256" checksum="B938E05B7E4538B3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW50</accession>
    <name>Q5CW50_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DNA polymerase delta2, inactive calcineurin like phosphatase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_1620</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase delta/II small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627069.1">
        <property type="nucleotide sequence ID" value="XM_627069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW50"/>
    <dbReference type="FunCoup" id="Q5CW50">
        <property type="interactions" value="264"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW50"/>
    <dbReference type="GeneID" id="3374598"/>
    <dbReference type="KEGG" id="cpv:cgd8_1620"/>
    <dbReference type="InParanoid" id="Q5CW50"/>
    <dbReference type="OMA" id="HCILIGT"/>
    <dbReference type="OrthoDB" id="3763at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006271">
        <property type="term" value="P:DNA strand elongation involved in DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07387">
        <property type="entry name" value="MPP_PolD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040663">
        <property type="entry name" value="DNA_pol_D_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024826">
        <property type="entry name" value="DNA_pol_delta/II_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041863">
        <property type="entry name" value="PolD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10416:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18018">
        <property type="entry name" value="DNA_pol_D_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase delta subunit OB-fold" evidence="6">
        <location>
            <begin position="34"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="5">
        <location>
            <begin position="213"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="475" mass="53404" checksum="EBC99C7DDFD5D7C6" modified="2005-04-12" version="1">MKLEKDVKSLKRPEVDIKNECERFRVKDYSFPHQYCHLCFSRFMSLRPFLLKAVQRKWKCHLSVEQEKVEKIASQGNPEDRSIPILNELKDMKIESECIIMGFVTKEMKNRPTILDEYLQDIEEATKNSQLSNYTSNDDKVYIEDSSSRIPLTLKEDVFSMNNLISGTILAVRGVQNSGGNFLVSDLTFASPPEEIIGKEYTLGKSSQPVYLAFVSGLNIGSEIENSLSLQLFRDFIMGVSSYSSEHKLLSSQIAYLIIAGNIIRLLDTAKETVTGTGTKLVVNNELLSSRLGVVDSFISQLASTISLAIMPGEDDPVPISLPQPPFQPYIFKNSRNYQSFNSFTNPCLFSINNVRVTGVSGQCISKISLFSSYSKPIDALKFCVESRNIAPTCPDVIPTYPFFDRDPFALDYTDESFPQVIFAGNQSEFGSYRFPNNGPLCFTIPEFSNNPTLVLLDINSYELKTISFKTSLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW55</accession>
    <name>Q5CW55_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCCH like finger domain nucleoporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_1570</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627064.1">
        <property type="nucleotide sequence ID" value="XM_627064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW55"/>
    <dbReference type="GeneID" id="3374476"/>
    <dbReference type="KEGG" id="cpv:cgd8_1570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1570"/>
    <dbReference type="InParanoid" id="Q5CW55"/>
    <dbReference type="OMA" id="HQENIDI"/>
    <dbReference type="OrthoDB" id="344321at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051767">
        <property type="entry name" value="Nucleoporin_NUP42"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527:SF1">
        <property type="entry name" value="NUCLEOPORIN NUP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46527">
        <property type="entry name" value="NUCLEOPORIN-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="135"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="187"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="439"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="454"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="570" mass="59128" checksum="399DC70A7E91AF27" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWA4</accession>
    <name>Q5CWA4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">STXBP/UNC-18/SEC1 syntaxin involved in golgi transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627015.1">
        <property type="nucleotide sequence ID" value="XM_627015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWA4"/>
    <dbReference type="FunCoup" id="Q5CWA4">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWA4"/>
    <dbReference type="GeneID" id="3374562"/>
    <dbReference type="KEGG" id="cpv:cgd8_1080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1080"/>
    <dbReference type="InParanoid" id="Q5CWA4"/>
    <dbReference type="OMA" id="PFTRPHT"/>
    <dbReference type="OrthoDB" id="2228at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043154">
        <property type="entry name" value="Sec-1-like_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005715">
        <property type="entry name" value="VPS45_Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="662" mass="75598" checksum="FAF82265D26F3C7C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWB0</accession>
    <name>Q5CWB0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627009.1">
        <property type="nucleotide sequence ID" value="XM_627009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWB0"/>
    <dbReference type="GeneID" id="3374434"/>
    <dbReference type="KEGG" id="cpv:cgd8_1010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1010"/>
    <dbReference type="InParanoid" id="Q5CWB0"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="150" mass="17080" checksum="75123670CA733635" modified="2005-04-12" version="1">MLFFPPLFPLSSSFSSLLLSSRLTKSCSTPKSLDKLDLFLLISGRVISSILPIFELFPLPLKRIFSKFNSSILLFAKSKTKFSASNDKTNSPFRSLLLLLLKLSPFKLSDEFIEINSVNKEFFFSPLFLLTNVLQLFLFSVSFLPSLNYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWC5</accession>
    <name>Q5CWC5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane associated protein with 8 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626994.1">
        <property type="nucleotide sequence ID" value="XM_626994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWC5"/>
    <dbReference type="GeneID" id="3374415"/>
    <dbReference type="KEGG" id="cpv:cgd8_850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_850"/>
    <dbReference type="InParanoid" id="Q5CWC5"/>
    <dbReference type="OMA" id="AFTICRV"/>
    <dbReference type="OrthoDB" id="341235at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="86"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="233"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="313"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="346"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="410"/>
            <end position="436"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="446" mass="51244" checksum="D5C5F39866783B97" modified="2005-04-12" version="1">MNSLENQKSIKEGEIELENVLVKQPILKEVDEKIENFTENDSEPTVQVNLKEDCHLVALNIGSLNSAKSSVSSLEFIRQYTDKKEAIFLFAEYLLLISSIILGIYITYQEYELEKFLKNKNGFEKTANYVKQANIMTIITTTVMATQLIINCIFGILFILFKQGIIVRWINIFKSKLFIDQVFIWQSPFISLPIIITAMVKLMVNCRSNLEEIMVLRESTLIIETSNFALNKLYFIIIYYSVYLSTNFVMELFVVRRQYLGNFIQSQRLGILDYSIAYIGNAALVASLILYFFKFRYSSSAESNIDLKSQVDYYYRTVLAAATHSGLIAILVGILGYIASLSCSKMLILISLIVKFYSTFVFSWSCSLVWFGNHLLKLFCNVDSIAPNLYSLPTQDYLAFKNACFTRPNFYMITVLVIIQLTLSIFTLVLNFQFLISKKIWKSESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWD1</accession>
    <name>Q5CWD1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F11M21.28-like protein with 3 CCCH RNA binding domains involved in RNA metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_780</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626988.1">
        <property type="nucleotide sequence ID" value="XM_626988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWD1"/>
    <dbReference type="GeneID" id="3374522"/>
    <dbReference type="KEGG" id="cpv:cgd8_780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_780"/>
    <dbReference type="InParanoid" id="Q5CWD1"/>
    <dbReference type="OrthoDB" id="20534at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045234">
        <property type="entry name" value="Unkempt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493:SF50">
        <property type="entry name" value="RING FINGER PROTEIN UNKEMPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493">
        <property type="entry name" value="UNKEMPT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="63"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="334" mass="39490" checksum="35695A6EF7CF669B" modified="2005-04-12" version="1">MRKDRNSLNYNRSIIVKKEENEINQTESLNQGVEKNALISNIHGAEDSNKKHYLLTIYELYVFRTVVCSSHLQGKCKNSDSCPFSHCLTWQRRNPNDHYYSPKLCPEICFVKSNEKMNLIRRCRKGKLCTFAHSKEEQLYHPLMYKTKECSLYPNCNRYYCPFSHGIEQIRAPEKVRESIEEVIKNNSQGILKNPYLLLSSIVETGNKSKNDIRINKHKKSYLDVTQNKKDTLLMSKQQNPRFNDNKINTIQELEEKDINSIWDSVDNWNLNAPNINFHPAFMEIMSFNEQDQRLVHPDFDPCSFRNIAPENKFETEYDQIWKEISTEYNKKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWD9</accession>
    <name>Q5CWD9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted secreted protein, signal peptide with several threonines, possible mucin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626980.1">
        <property type="nucleotide sequence ID" value="XM_626980.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWD9"/>
    <dbReference type="GeneID" id="3374490"/>
    <dbReference type="KEGG" id="cpv:cgd8_700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_700"/>
    <dbReference type="InParanoid" id="Q5CWD9"/>
    <dbReference type="OrthoDB" id="343978at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052258">
        <property type="entry name" value="Diverse_Func_Domain-Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37612">
        <property type="entry name" value="FIBROIN HEAVY CHAIN FIB-H LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37612:SF20">
        <property type="entry name" value="PER-HEXAMER REPEAT PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="172"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1365"/>
            <end position="1458"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="926"/>
            <end position="953"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="199"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="254"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1365"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1390"/>
            <end position="1458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1912" mass="216019" checksum="E56F13B97F88B20E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWF4</accession>
    <name>Q5CWF4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_5310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627850.1">
        <property type="nucleotide sequence ID" value="XM_627850.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3375844"/>
    <dbReference type="KEGG" id="cpv:cgd6_5310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5310"/>
    <dbReference type="InParanoid" id="Q5CWF4"/>
    <dbReference type="OMA" id="HEYLELP"/>
    <dbReference type="OrthoDB" id="338919at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254489" evidence="1">
        <location>
            <begin position="24"/>
            <end position="1302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1302" mass="148346" checksum="B2CB89DF3F9B1CA4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWP5</accession>
    <name>Q5CWP5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 6">GPN-loop GTPase 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_4270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627759.1">
        <property type="nucleotide sequence ID" value="XM_627759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWP5"/>
    <dbReference type="FunCoup" id="Q5CWP5">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWP5"/>
    <dbReference type="GeneID" id="3375770"/>
    <dbReference type="KEGG" id="cpv:cgd6_4270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4270"/>
    <dbReference type="InParanoid" id="Q5CWP5"/>
    <dbReference type="OMA" id="LYTHMTV"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17872">
        <property type="entry name" value="GPN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030228">
        <property type="entry name" value="Gpn3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF7">
        <property type="entry name" value="GPN-LOOP GTPASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014587"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="267" mass="30027" checksum="F7C98316627783ED" modified="2007-04-03" version="1">MRFAQLVVGPAGSGKSTYCSTIQKHCEVIGRTCHVVNLDPAAEHFNYVSQLDIRDLISLNDVMEEIHLGPNGGQVFAMEYFIENLDWLEEQLNKNFGDNDYVLFDCPGQIELFTHLPVMRILVTALQRWDFRICGVYCLDVGFLTDASKFVAGSVSALSTMIQLEIPHVNVITKCDIVQDENLVSSFLQKDSLTLISDLEKVTPSHIMPLNVALANLLEDYSIVSYVPLKPDDEDSVSNVLLSIDMNLQFHEEQDPTMNFDINGDEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWQ3</accession>
    <name>Q5CWQ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_4180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627751.1">
        <property type="nucleotide sequence ID" value="XM_627751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWQ3"/>
    <dbReference type="FunCoup" id="Q5CWQ3">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWQ3"/>
    <dbReference type="GeneID" id="3375906"/>
    <dbReference type="KEGG" id="cpv:cgd6_4180"/>
    <dbReference type="InParanoid" id="Q5CWQ3"/>
    <dbReference type="OMA" id="MMYCHAI"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="100"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="170" mass="19637" checksum="0A47A52A9C3C149B" modified="2005-04-12" version="1" fragment="single">RRRIVNDINKLRKEVYQGIRVMPFSQNMMYCQAIINGPKDTFWESGKSNIIKKFNLYTSTPIGTFNLIMQFSEEYPTKPPDVRFLSKMFHPNIYPDGRICLDILQNQWSALIDIASVLTSIQSLLSDPNPNSPANTIASEMYVKERNKYNSKVLECVEESWSTPSYSIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWV0</accession>
    <name>Q5CWV0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein with ankyrin repeats, signal peptide plus transmembrane domain or GPI anchor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_3630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627704.1">
        <property type="nucleotide sequence ID" value="XM_627704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWV0"/>
    <dbReference type="SMR" id="Q5CWV0"/>
    <dbReference type="GeneID" id="3375725"/>
    <dbReference type="KEGG" id="cpv:cgd6_3630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3630"/>
    <dbReference type="InParanoid" id="Q5CWV0"/>
    <dbReference type="OMA" id="IGHITPT"/>
    <dbReference type="OrthoDB" id="163438at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254585" evidence="4">
        <location>
            <begin position="19"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="233"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="600"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="111"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="233"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="606"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="670" mass="74955" checksum="85B950BB2E188F0C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWW3</accession>
    <name>Q5CWW3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_3480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627691.1">
        <property type="nucleotide sequence ID" value="XM_627691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWW3"/>
    <dbReference type="GeneID" id="3375712"/>
    <dbReference type="KEGG" id="cpv:cgd6_3480"/>
    <dbReference type="InParanoid" id="Q5CWW3"/>
    <dbReference type="OMA" id="PAECILI"/>
    <dbReference type="OrthoDB" id="336313at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="171" mass="19531" checksum="8D052C1E75C8148A" modified="2007-04-03" version="1">MVIVFRGSEVIENGVLYLLYKACRIFKQLGVEYVTIFEPNGIVESKLTVLLNNEDEIPANLRFLSSGDSSKDFLNKIQRIVEQKHNSNEKEVTYREIYSILNSGGNWPKADCILILRNMPFDIPINGFNSLFVILNRLREYTASFCTRLFIVTSLGTWGEIPPLLAQHAEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX01</accession>
    <name>Q5CX01_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627653.1">
        <property type="nucleotide sequence ID" value="XM_627653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX01"/>
    <dbReference type="GeneID" id="3375682"/>
    <dbReference type="KEGG" id="cpv:cgd6_3070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3070"/>
    <dbReference type="InParanoid" id="Q5CX01"/>
    <dbReference type="OrthoDB" id="341473at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254497" evidence="1">
        <location>
            <begin position="23"/>
            <end position="599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="599" mass="69119" checksum="CEF1E109B8251399" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX70</accession>
    <name>Q5CX70_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane-associated protein with 12 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627584.1">
        <property type="nucleotide sequence ID" value="XM_627584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX70"/>
    <dbReference type="GeneID" id="3376176"/>
    <dbReference type="KEGG" id="cpv:cgd6_2270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2270"/>
    <dbReference type="InParanoid" id="Q5CX70"/>
    <dbReference type="OMA" id="EVICYYS"/>
    <dbReference type="OrthoDB" id="342376at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="42"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="122"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="416"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="464"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="540"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="591"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="615"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="691" mass="79419" checksum="55EF04B4E64330A1" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX82</accession>
    <name>Q5CX82_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627572.1">
        <property type="nucleotide sequence ID" value="XM_627572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX82"/>
    <dbReference type="GeneID" id="3376166"/>
    <dbReference type="KEGG" id="cpv:cgd6_2120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2120"/>
    <dbReference type="InParanoid" id="Q5CX82"/>
    <dbReference type="OrthoDB" id="338387at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="211"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="214" mass="25317" checksum="9670A33163EC2B36" modified="2007-04-03" version="1">MSTLFLPETPKEKERDDLKLINTFSKGTNEKNLSLFEETDLLIKIQNSKSENYEEHLDYLGSDDRLLVNDCLNRTPVKKRYNKEYSFTQSNKLLTTPKKYFGEDILNTVPKNMVMFTNYVDKSLSNKRCNTKLNNTWQKSKFRRSLIRMKSACNKQCKFCNPEFSCTNISIKSVKKNLKEWFIYLFNALYDFIIYQLPLALIFYSFAIYLLSCL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX98</accession>
    <name>Q5CX98_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Ribonucleoside-diphosphate reductase</fullName>
            <ecNumber evidence="3 12">1.17.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd6_1950</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9 12">Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol</text>
            <dbReference type="Rhea" id="RHEA:23252"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="ChEBI" id="CHEBI:57930"/>
            <dbReference type="ChEBI" id="CHEBI:73316"/>
            <dbReference type="EC" id="1.17.4.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="2">Heterodimer of a large and a small subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 12">Belongs to the ribonucleoside diphosphate reductase large chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.17.4.1" evidence="3 12"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627556.1">
        <property type="nucleotide sequence ID" value="XM_627556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX98"/>
    <dbReference type="FunCoup" id="Q5CX98">
        <property type="interactions" value="378"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX98"/>
    <dbReference type="GeneID" id="3375878"/>
    <dbReference type="KEGG" id="cpv:cgd6_1950"/>
    <dbReference type="InParanoid" id="Q5CX98"/>
    <dbReference type="OMA" id="IELPQHM"/>
    <dbReference type="OrthoDB" id="3000483at2759"/>
    <dbReference type="UniPathway" id="UPA00326"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005971">
        <property type="term" value="C:ribonucleoside-diphosphate reductase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004748">
        <property type="term" value="F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01679">
        <property type="entry name" value="RNR_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.70.20:FF:000010">
        <property type="entry name" value="Ribonucleoside-diphosphate reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.70.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005144">
        <property type="entry name" value="ATP-cone_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013346">
        <property type="entry name" value="NrdE_NrdA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000788">
        <property type="entry name" value="RNR_lg_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013509">
        <property type="entry name" value="RNR_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008926">
        <property type="entry name" value="RNR_R1-su_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039718">
        <property type="entry name" value="Rrm1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02506">
        <property type="entry name" value="NrdE_NrdA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11573:SF6">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03477">
        <property type="entry name" value="ATP-cone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02867">
        <property type="entry name" value="Ribonuc_red_lgC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00317">
        <property type="entry name" value="Ribonuc_red_lgN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01183">
        <property type="entry name" value="RIBORDTASEM1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51998">
        <property type="entry name" value="PFL-like glycyl radical enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48168">
        <property type="entry name" value="R1 subunit of ribonucleotide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51161">
        <property type="entry name" value="ATP_CONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00089">
        <property type="entry name" value="RIBORED_LARGE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12" id="KW-0215">Deoxyribonucleotide synthesis</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-cone" evidence="13">
        <location>
            <begin position="2"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK90133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="804" mass="91236" checksum="D7A32292A4669406" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXA4</accession>
    <name>Q5CXA4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627550.1">
        <property type="nucleotide sequence ID" value="XM_627550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXA4"/>
    <dbReference type="GeneID" id="3376064"/>
    <dbReference type="KEGG" id="cpv:cgd6_1860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1860"/>
    <dbReference type="InParanoid" id="Q5CXA4"/>
    <dbReference type="OrthoDB" id="343228at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="114" mass="13638" checksum="0917A276F8BB3DF2" modified="2005-04-12" version="1">MLKILGFLMACFQQSNNQYYKDDKFKDCSDSNSLVKYTSIGIKIIVYSISWIMVLIWDAYEYGMVFYGLILSIYILKYYSKYSCLRCVFEEIFKKQILKHIFPKSLNKIVEWQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXG9</accession>
    <name>Q5CXG9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_1130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627485.1">
        <property type="nucleotide sequence ID" value="XM_627485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXG9"/>
    <dbReference type="GeneID" id="3376029"/>
    <dbReference type="KEGG" id="cpv:cgd6_1130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1130"/>
    <dbReference type="InParanoid" id="Q5CXG9"/>
    <dbReference type="OrthoDB" id="340958at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254603" evidence="2">
        <location>
            <begin position="29"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="287"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="608" mass="70785" checksum="FBA62517F818F2C8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXH1</accession>
    <name>Q5CXH1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal peptide-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627483.1">
        <property type="nucleotide sequence ID" value="XM_627483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXH1"/>
    <dbReference type="GeneID" id="3376027"/>
    <dbReference type="KEGG" id="cpv:cgd6_1110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1110"/>
    <dbReference type="InParanoid" id="Q5CXH1"/>
    <dbReference type="OMA" id="TIVECVE"/>
    <dbReference type="OrthoDB" id="339460at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254345" evidence="1">
        <location>
            <begin position="19"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="458" mass="52374" checksum="D2731F9E5C7BC971" modified="2007-04-03" version="1">MEIKIFWLLLFCVKFAREVILTTGNENIYSGLEKELGDEQDLDQAKLIDSIRKIGSDAQHTEPFQPLLDASEEKQDEKDSIIDAAKVTSARKSESLPTSAEKIDLIGAGISDSRKDTGAKASAPDFKFGEPGPSIREEELEMYVHPSEELIFSIPIPTMKPEHQFNTIRRLSGSKYRGLPKAHQNERGNVNWCKIIATREPEIMTKVNNIYRMIQSDLVSVLGGIGLDGSSSNQGYSGSRAGSGWTQQHICEGIYLLNTYRGEGDCERIFVDLMARFHGQWSLFYKMFRQKFRQICKEAGYSTGRWDVYNDRAYSQYSVLRSAKKPIKTEPTKERREFVRLLRTRSGICSLLPQNLREKAIQLKTSVDNIPQIKHITQRISLSDYCDIILGKQSIIECAEALITFFKLKAETYYDSTERYRPIRSLLIKACDDALFHEKDSNTRPEKVSQYDRMENKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXJ8</accession>
    <name>Q5CXJ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative secreted low complexity protein with a signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627456.1">
        <property type="nucleotide sequence ID" value="XM_627456.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXJ8"/>
    <dbReference type="GeneID" id="3376081"/>
    <dbReference type="KEGG" id="cpv:cgd6_820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_820"/>
    <dbReference type="InParanoid" id="Q5CXJ8"/>
    <dbReference type="OMA" id="SEIMRCQ"/>
    <dbReference type="OrthoDB" id="342856at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254347" evidence="2">
        <location>
            <begin position="22"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="223"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="304" mass="34123" checksum="ABFBEF8A80BA2F24" modified="2007-04-03" version="1">MNKKIIISIIIGLLSITFVQASTVQSQFFNPLSIFSGIGNLFNGITKGIQNIFETFIKEIIPPPQLIDPKYDIRSITSVQQDILKNMPILENDLNSVGEVVNEMAVGASINAAKGLQITQSVLKPDMTGASEALRNLKSVDSVDKKKSLKSAAKAKSREFLESLSKPSEIVSDYTAPIIVIQAPESDPTQLMTINEIIKCRGGKNWITAQEHMIKMKEYRKLKGKKKKLLDEEIEQINQLLDEKDTIMTDLRNKLRANEVKMVESPSDVTTLENKLLNQQMGYLAEEIVVLDKQLEKLHRKKKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXM8</accession>
    <name>Q5CXM8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627426.1">
        <property type="nucleotide sequence ID" value="XM_627426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXM8"/>
    <dbReference type="GeneID" id="3376105"/>
    <dbReference type="KEGG" id="cpv:cgd6_430"/>
    <dbReference type="InParanoid" id="Q5CXM8"/>
    <dbReference type="OrthoDB" id="10399165at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="111" mass="12709" checksum="A68D28853B548A88" modified="2005-04-12" version="1">MKRKNILFNLIIFCFSIMQVILGKKVNILIDDMGTIHKETLLDMNNKNINTDTNINNNGNSISNWKGSLMDLKDPLNSSENNRKLDQDNSIICECKIMVSKCKYSILIKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXN5</accession>
    <name>Q5CXN5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine/threonine rich low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_5520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628695.1">
        <property type="nucleotide sequence ID" value="XM_628693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXN5"/>
    <dbReference type="STRING" id="353152.Q5CXN5"/>
    <dbReference type="GeneID" id="3372159"/>
    <dbReference type="KEGG" id="cpv:cgd7_5520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5520"/>
    <dbReference type="InParanoid" id="Q5CXN5"/>
    <dbReference type="OrthoDB" id="344334at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033272">
        <property type="entry name" value="Hemogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15993">
        <property type="entry name" value="HEMOGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15993:SF6">
        <property type="entry name" value="HEMOGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88633">
        <property type="entry name" value="Positive stranded ssRNA viruses"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="487"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="489"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="516"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="538"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="552"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="693"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="735"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="833"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="885"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="898"/>
            <end position="913"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="951" mass="102120" checksum="3702EC51A2A114A7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXR9</accession>
    <name>Q5CXR9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Eukaryotic translation initiation factor 3 subunit H</fullName>
            <shortName evidence="1">eIF3h</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_5180</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-3 subunit H family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628661.1">
        <property type="nucleotide sequence ID" value="XM_628659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXR9"/>
    <dbReference type="FunCoup" id="Q5CXR9">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXR9"/>
    <dbReference type="GeneID" id="3372092"/>
    <dbReference type="KEGG" id="cpv:cgd7_5180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5180"/>
    <dbReference type="InParanoid" id="Q5CXR9"/>
    <dbReference type="OMA" id="WYQSTYF"/>
    <dbReference type="OrthoDB" id="10265695at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd08065">
        <property type="entry name" value="MPN_eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03007">
        <property type="entry name" value="eIF3h"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027524">
        <property type="entry name" value="eIF3h"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045810">
        <property type="entry name" value="eIF3h_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19445">
        <property type="entry name" value="eIF3h_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="1" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF3h C-terminal" evidence="3">
        <location>
            <begin position="263"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="32"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="58"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF19445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="450" mass="50470" checksum="9230B06850EFBB8B" modified="2005-04-12" version="1">MIGKDGLIGLSSNPMEGATQTTKHVGWGISRQTEDKDSKEEVQQLSGSSGISGGKGSGYFQSQSGGQQISQGSLSSGTGHHQHYSFSSGNTIGNSGGSSHYKHLSTKTTVSSVEADISAILRIIKHCTENYSQMNATGQLLGMEYGNKLEITTSFQLPTREDLLPSLMSNYSGGKLDKSEKLDLEERLVEEVDKYQAAMVELMHEIRSDCFVLGWYQLIRLDDFQDYGVVSTLLSYYNNIESKNAILLSIDPDLLIQGKKNAFKAFTLNSEYASKLKDDEDNFHIFKNASFEDILVEVPIYIKYPVLSEAFLLDWITSDVLQSTIDYSELSINTKTPLDINDKALLNLAESIDVLSLEQEKLYKGYRDYNKQQYLIKQMAERRRIENEQRKLKGETPLPIDTESIKKVDPPNPLPVILVSKYVESQCNEINFNSKESLTKVLIRNIKNDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXS7</accession>
    <name>Q5CXS7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein disulfide isomerase, signal peptide plus ER retention motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_5100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628653.1">
        <property type="nucleotide sequence ID" value="XM_628651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXS7"/>
    <dbReference type="STRING" id="353152.Q5CXS7"/>
    <dbReference type="GeneID" id="3372085"/>
    <dbReference type="KEGG" id="cpv:cgd7_5100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5100"/>
    <dbReference type="InParanoid" id="Q5CXS7"/>
    <dbReference type="OMA" id="MLIYIDI"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255069" evidence="2">
        <location>
            <begin position="26"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="8"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="556" mass="64531" checksum="AEAEF0642707E126" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY04</accession>
    <name>Q5CY04_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TCP-1 chaperonin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_4220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628576.1">
        <property type="nucleotide sequence ID" value="XM_628574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY04"/>
    <dbReference type="FunCoup" id="Q5CY04">
        <property type="interactions" value="497"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY04"/>
    <dbReference type="GeneID" id="3372078"/>
    <dbReference type="KEGG" id="cpv:cgd7_4220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4220"/>
    <dbReference type="InParanoid" id="Q5CY04"/>
    <dbReference type="OMA" id="LHPRIMT"/>
    <dbReference type="OrthoDB" id="10052040at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03342">
        <property type="entry name" value="TCP1_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000038">
        <property type="entry name" value="Chaperonin containing TCP1 subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000058">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000004">
        <property type="entry name" value="T-complex protein 1 subunit zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012722">
        <property type="entry name" value="Chap_CCT_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02347">
        <property type="entry name" value="chap_CCT_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="532" mass="58347" checksum="B4B0B4855C2A8AF0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYM9</accession>
    <name>Q5CYM9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CpCCp1/Cpa135</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_1730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628351.1">
        <property type="nucleotide sequence ID" value="XM_628349.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CYM9"/>
    <dbReference type="FunCoup" id="Q5CYM9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYM9"/>
    <dbReference type="GeneID" id="3371736"/>
    <dbReference type="KEGG" id="cpv:cgd7_1730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1730"/>
    <dbReference type="InParanoid" id="Q5CYM9"/>
    <dbReference type="OMA" id="NFCEECC"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255088" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1556"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="2">
        <location>
            <begin position="751"/>
            <end position="827"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1556" mass="172758" checksum="2AAC65FBC43B4C1E" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYN7</accession>
    <name>Q5CYN7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ncl1p/MJ0026/YebU-like. SUN family RNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_1630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628343.1">
        <property type="nucleotide sequence ID" value="XM_628341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYN7"/>
    <dbReference type="STRING" id="353152.Q5CYN7"/>
    <dbReference type="GeneID" id="3371787"/>
    <dbReference type="KEGG" id="cpv:cgd7_1630"/>
    <dbReference type="InParanoid" id="Q5CYN7"/>
    <dbReference type="OMA" id="ILADMPC"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057285">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808:SF1">
        <property type="entry name" value="RNA CYTOSINE-C(5)-METHYLTRANSFERASE NSUN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25376">
        <property type="entry name" value="Pre-PUA_NSUN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="6">
        <location>
            <begin position="93"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="346"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="205"/>
            <end position="211"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="240"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="713" mass="80950" checksum="94B98A72AE34477A" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYR4</accession>
    <name>Q5CYR4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Extracellular protein with a signal peptide followed by a family 2 glycosyltransferase and ricin domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_1310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628316.1">
        <property type="nucleotide sequence ID" value="XM_628314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYR4"/>
    <dbReference type="STRING" id="353152.Q5CYR4"/>
    <dbReference type="GeneID" id="3371859"/>
    <dbReference type="KEGG" id="cpv:cgd7_1310"/>
    <dbReference type="InParanoid" id="Q5CYR4"/>
    <dbReference type="OMA" id="CPMIEDI"/>
    <dbReference type="OrthoDB" id="416652at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF119">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="10" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="9">
        <location>
            <begin position="54"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="545" mass="63209" checksum="FB50B945E7F00671" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPS7</accession>
    <name>A3FPS7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein phosphatase-1 regulatory subunit 7 alpha2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388306.1">
        <property type="nucleotide sequence ID" value="XM_001388269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPS7"/>
    <dbReference type="STRING" id="353152.A3FPS7"/>
    <dbReference type="GeneID" id="3375930"/>
    <dbReference type="KEGG" id="cpv:cgd6_750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_750"/>
    <dbReference type="InParanoid" id="A3FPS7"/>
    <dbReference type="OMA" id="EVWASYN"/>
    <dbReference type="OrthoDB" id="7451790at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13855">
        <property type="entry name" value="LRR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="340" mass="39571" checksum="5929FF217AAC5909" modified="2007-04-03" version="1">MNSEKEIKQDNSQNVSKDSESEEEPIKSLRIGIDYPVYDDDEEINIQCGRIGEIENLSKCKELRSLMLISNHIRKIKNLDELIQLKTLELYQNKIKKIENLEKLVNLEVLDLSFNRIKKLENLENQNKLKKLFLTNNKIKIIQGLNNNKELKLLELGSNDIRIIENIDHLSELEELWLGKNKITTLDDIPLFQNIKIISLQSNRIVNWSINFSKNVNNVQELYLSDNQLISPDEVYFDSFQNLKVLDLGGNKIQNLEAISKIESLEELWINDNDICDINQLELLKNLRNLQTLYLERNPIQNQLGPAYRLTVIKIVPWITQLDAIPINRSGEIHFIQSSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPW5</accession>
    <name>A3FPW5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Elongation factor 1-alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_3990</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388344.1">
        <property type="nucleotide sequence ID" value="XM_001388307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPW5"/>
    <dbReference type="SMR" id="A3FPW5"/>
    <dbReference type="FunCoup" id="A3FPW5">
        <property type="interactions" value="183"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPW5"/>
    <dbReference type="GeneID" id="3375970"/>
    <dbReference type="KEGG" id="cpv:cgd6_3990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3990"/>
    <dbReference type="InParanoid" id="A3FPW5"/>
    <dbReference type="OMA" id="AIRDMGM"/>
    <dbReference type="OrthoDB" id="407705at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01883">
        <property type="entry name" value="EF1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03693">
        <property type="entry name" value="EF1_alpha_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03705">
        <property type="entry name" value="EF1_alpha_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000003">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000005">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000255">
        <property type="entry name" value="Elongation factor 1-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00118_A">
        <property type="entry name" value="EF_Tu_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054696">
        <property type="entry name" value="GTP-eEF1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004539">
        <property type="entry name" value="Transl_elong_EF1A_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00483">
        <property type="entry name" value="EF-1_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008969">
        <property type="entry name" value="PRK12317.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22594">
        <property type="entry name" value="GTP-eEF1A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8 10" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="7 8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="5"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="435" mass="48162" checksum="911FBE41044F703F" modified="2007-04-03" version="1">MGKEKTHINLVVIGHVDSGKSTTTGHLIYKLGGIDKRTIEKFEKESSEMGKGSFKYAWVLDKLKAERERGITIDIALWQFETPKYHYTVIDAPGHRDFIKNMITGTSQADVALLVVPADRFEGAFSKEGQTREHALLAFTLGVRQMIVGINKMDTCEYKQSRFDEIFNEVDGYLKKVGYNTEKIPFVAISGFVGDNMVERSDKMPWYKGKTLVEALDTMEPPKRPTDKPLRLPLQDVYKIGGVGTVPVGRVETGIIRPGMNVTFAPAGVTTEVKSVEMHHEQMPEAVPGDNVGFNVKNVSIKDIKRGFVASDAKNDPAKGCEDFTAQVIVLNHPGEIKNGYSPVVDCHTAHISCKFQTITAKMDKRSGKVLEENPKLIKSGDAALVVMQPLKPLCVEAFTDYPPLGRFAVRDMKQTVAVGVIKSVTKKEATSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPX7</accession>
    <name>A3FPX7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_5040</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the TFB4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388356.1">
        <property type="nucleotide sequence ID" value="XM_001388319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPX7"/>
    <dbReference type="FunCoup" id="A3FPX7">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPX7"/>
    <dbReference type="GeneID" id="3375981"/>
    <dbReference type="KEGG" id="cpv:cgd6_5040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5040"/>
    <dbReference type="InParanoid" id="A3FPX7"/>
    <dbReference type="OrthoDB" id="17307at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004600">
        <property type="entry name" value="TFIIH_Tfb4/GTF2H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12831">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIH TFIIH , POLYPEPTIDE 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03850">
        <property type="entry name" value="Tfb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="7 11" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 11" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="286" mass="32320" checksum="44EB89251EAA920A" modified="2007-04-03" version="1">MEGTLYIILDSRSLFRYEDTGESQSNAQSNLLVSGECVLNSIFQFTRLYNLSTGQKKKLNIYLCDSKGENLLFDGFISGLTKELQFEIMPKMLEEISERISLGEMKMSPTISKCLCKINSTRKKFGYNRSEKDRIILLDASNKDEYISQYVSLLNCGFASQKLDVVIDVVSVTRNPSPLLNNLVDICNGLNLKYSQIVDSLAESNIEINKEDHHWLDQGLTPFLIFHLLPSIQAREEIFISINKTKQTGLAVCFCHHQKIEIGYVCSSCLSIFCSRFKAPICSTCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPZ7</accession>
    <name>A3FPZ7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-fold modifier-conjugating enzyme 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_3630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388438.1">
        <property type="nucleotide sequence ID" value="XM_001388401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPZ7"/>
    <dbReference type="STRING" id="353152.A3FPZ7"/>
    <dbReference type="GeneID" id="3374657"/>
    <dbReference type="KEGG" id="cpv:cgd8_3630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3630"/>
    <dbReference type="InParanoid" id="A3FPZ7"/>
    <dbReference type="OMA" id="LWQKNVP"/>
    <dbReference type="OrthoDB" id="10256182at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061657">
        <property type="term" value="F:UFM1 conjugating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990592">
        <property type="term" value="P:protein K69-linked ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11686">
        <property type="entry name" value="UBCc_UFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014806">
        <property type="entry name" value="Ufc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12921:SF0">
        <property type="entry name" value="UBIQUITIN-FOLD MODIFIER-CONJUGATING ENZYME 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08694">
        <property type="entry name" value="UFC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="155" mass="18018" checksum="43D1DCCA7E9ED964" modified="2007-04-03" version="1" fragment="single">MNNYSTLEKLPQITINAGPLDNLWPERLKEELKVLIGYVALLKDSGEEWFNIKPLQDGTKWEGVCWYTHNLKRYEFAFRFNIPEKYPITPFEVEIPELDGKTLKMYRGGKICMDTHFIPLWLRNCPKFGIVHILAFGLAPWLAAEVPFLVSSCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQA4</accession>
    <name>A3FQA4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Enhancer of rudimentary homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the E(R) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388240.1">
        <property type="nucleotide sequence ID" value="XM_001388203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQA4"/>
    <dbReference type="FunCoup" id="A3FQA4">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQA4"/>
    <dbReference type="GeneID" id="3373667"/>
    <dbReference type="KEGG" id="cpv:cgd2_3910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3910"/>
    <dbReference type="InParanoid" id="A3FQA4"/>
    <dbReference type="OMA" id="ESRTWSD"/>
    <dbReference type="OrthoDB" id="7887808at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2260.10">
        <property type="entry name" value="Enhancer of rudimentary"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035912">
        <property type="entry name" value="EHR_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000781">
        <property type="entry name" value="ERH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12373">
        <property type="entry name" value="ENHANCER OF RUDIMENTARY ERH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12373:SF0">
        <property type="entry name" value="ENHANCER OF RUDIMENTARY HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01133">
        <property type="entry name" value="ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143875">
        <property type="entry name" value="ERH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="12466" checksum="56F55F25FBB3E9D7" modified="2007-04-03" version="1">MAQNQGLHTLLLIQYSNNISTRSYMDYDSVSQAVDGVCQIYEQSIKCAFSNLKEVTYSIEDLVKYINSLYDICMLTRDGTNRRYIPHDRKWIIDQIYLKMKRRAAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQH9</accession>
    <name>A3FQH9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_1320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388263.1">
        <property type="nucleotide sequence ID" value="XM_001388226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQH9"/>
    <dbReference type="STRING" id="353152.A3FQH9"/>
    <dbReference type="GeneID" id="3373363"/>
    <dbReference type="KEGG" id="cpv:cgd5_1320"/>
    <dbReference type="InParanoid" id="A3FQH9"/>
    <dbReference type="OMA" id="FFEEYEC"/>
    <dbReference type="OrthoDB" id="6220758at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.36.70">
        <property type="entry name" value="Actin, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="367" mass="41834" checksum="D850F08610D9AF1A" modified="2007-04-03" version="1" fragment="single">ISYQKYFNSLRHCFPNCIGKVRRKDKIYTSDQIYSLNEYFSYCPFSEGLLIDVSMENDIWEYIFNKMNISPGDIGLLVTEPFLNPSSLQHSLFEIIFEQFGFNKAIVTNPPAISQFAFNPQLIPNTEQQVINPCYLILDCGYQCCFSVPFFQGSPIYKACRRLDIGGYHLDLALKNFLSLRQVDLSRSSLIVSKIKESCCYISKNFDLDISRSPGNSPDNLVEQIYQLPELKPNSKNSNFYSQECISPDNIELENFNLKMESESSVNCDPSRIIKLYSERITVPELLFSPSNGGYNFTGIADMVSESILSSPKHLQELLANNILLIGGSTKFRNFEARLNKELSSLLPSVSLKLKHYHSTNLRSRGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQI4</accession>
    <name>A3FQI4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_1820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 5">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388268.1">
        <property type="nucleotide sequence ID" value="XM_001388231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQI4"/>
    <dbReference type="FunCoup" id="A3FQI4">
        <property type="interactions" value="485"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQI4"/>
    <dbReference type="MEROPS" id="T01.995"/>
    <dbReference type="GeneID" id="3373358"/>
    <dbReference type="KEGG" id="cpv:cgd5_1820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1820"/>
    <dbReference type="InParanoid" id="A3FQI4"/>
    <dbReference type="OMA" id="RSMIDHA"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03753">
        <property type="entry name" value="proteasome_alpha_type_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000054">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033812">
        <property type="entry name" value="Proteasome_alpha_type_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="6">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="255" mass="28102" checksum="D688D0774D06419A" modified="2007-04-03" version="1" fragment="single">MFASRNEYDRGVNTFSPEGRLFQVEYAIAAIKLGSTAVGIKTKEGVILASEKRISSPLLEPRNLEKIMIIDRHVGCCMSGLVADAKTMIDHARVESQNYFFTYNENIPTQSVVQSISDLALDFSDIKEKGKKKSMSRPFGVAMLIAGADSDGSSSLWMTDPSGTYTQYSAAAIGTAQEGAEAILLENYNSNMSLKEAEDLALIVLRQVMEEKINSVNVEVAAVKEKKFIIYDDKEIQRVLDRLPPPTHIVPSQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQP4</accession>
    <name>A3FQP4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="4">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_4070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 4">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAZ51229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388291.1">
        <property type="nucleotide sequence ID" value="XM_001388254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQP4"/>
    <dbReference type="STRING" id="353152.A3FQP4"/>
    <dbReference type="GeneID" id="3372563"/>
    <dbReference type="KEGG" id="cpv:cgd5_4070"/>
    <dbReference type="InParanoid" id="A3FQP4"/>
    <dbReference type="OMA" id="EGYNWGQ"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="5">
        <location>
            <begin position="145"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="239" mass="27240" checksum="AFFF7BD8304A2674" modified="2007-04-03" version="1">MDLENISQSQEVGSIEKENVSKEPVINGFILETNENEPFDLDKCIEKLLSCKPLSSNNIKQLCSKLKEILINESNVQKVRCPVTIAGDIHGQFFDLLELFRIGGMPPDVNYLFLGDYVDRGYHSIECICLIMALKIRYKDKVTILRGNHECRHISQIYGFYDECLRKYGNASIWHELTDMFDYLPLGALVEHHMFCDHGGLSPGALTIDEIDSINRFQEIPHEGPMCDLLWSDPDEKAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPS1</accession>
    <name>Q5CPS1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_4280</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
            <location evidence="1 5">Cytoskeleton</location>
            <location evidence="1 5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625443.1">
        <property type="nucleotide sequence ID" value="XM_625443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPS1"/>
    <dbReference type="STRING" id="353152.Q5CPS1"/>
    <dbReference type="GeneID" id="3372393"/>
    <dbReference type="KEGG" id="cpv:cgd4_4280"/>
    <dbReference type="InParanoid" id="Q5CPS1"/>
    <dbReference type="OrthoDB" id="78652at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302:SF27">
        <property type="entry name" value="GAMMA-TUBULIN COMPLEX COMPONENT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="6">
        <location>
            <begin position="2"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="311" mass="35969" checksum="DA73052678423D88" modified="2005-04-12" version="1">MIHDVLLSLTGFVGDKIEVDPVEFTSNSISLYSYKYRLRLKSNIEEYLSETEKLLVDKILHISSNFYSVNEFVKRVLGSVYNKHSNYNSNTNTNPAFGSKFNQEKSHQLQIRADLKKRLLRINPVGLYIHAVAKCMQEYILRFLQKINQLEREVFENPSLPLTFVLTSITKPSRVLDNFMAFIDEWYNLALNSRVDSTCKFSFSNMFITMEKFENLCEIYISIPCGYILDYFYLGVSSGDLLQESVSKNFLLVCSRIFCYQMINWIILGKLVDPFEEFIVGRFSISAPTNSLNSQKDANFSNSFSISSNDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPT1</accession>
    <name>Q5CPT1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_4170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625433.1">
        <property type="nucleotide sequence ID" value="XM_625433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPT1"/>
    <dbReference type="GeneID" id="3372403"/>
    <dbReference type="KEGG" id="cpv:cgd4_4170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4170"/>
    <dbReference type="InParanoid" id="Q5CPT1"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="153" mass="17806" checksum="3FB2FF7C59AB6485" modified="2005-04-12" version="1">MNYQVFQDNIKYIQKNVNHELEGNLYIIPSEPRTSSIITKSNMNHNNNNNNIEIIKPIPSLLENETTISTTLPFFNNITLELTITVSNEPKNNGEYVILKFAEFLNLLNYNISKYHNIEKILDNNNKDLNYVGIISINDFYKDDNEEFSISKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPW3</accession>
    <name>Q5CPW3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Large uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625516.1">
        <property type="nucleotide sequence ID" value="XM_625516.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372460"/>
    <dbReference type="KEGG" id="cpv:cgd8_550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_550"/>
    <dbReference type="InParanoid" id="Q5CPW3"/>
    <dbReference type="OMA" id="HYIVESS"/>
    <dbReference type="OrthoDB" id="342931at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2352" mass="267076" checksum="9EBE55FADBD65EC1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPX2</accession>
    <name>Q5CPX2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cleavage and polyadenylation specifity factor protein, CPSF metallobeta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625507.1">
        <property type="nucleotide sequence ID" value="XM_625507.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CPX2">
        <property type="interactions" value="476"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPX2"/>
    <dbReference type="GeneID" id="3372452"/>
    <dbReference type="KEGG" id="cpv:cgd8_460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_460"/>
    <dbReference type="InParanoid" id="Q5CPX2"/>
    <dbReference type="OMA" id="DNREVIC"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16292">
        <property type="entry name" value="CPSF3-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021718">
        <property type="entry name" value="CPSF73-100_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF11">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01098">
        <property type="entry name" value="CPSF73-100_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="6">
        <location>
            <begin position="36"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="7">
        <location>
            <begin position="269"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term" evidence="8">
        <location>
            <begin position="550"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="780" mass="88578" checksum="2696A3B3FE730720" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPY4</accession>
    <name>Q5CPY4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625495.1">
        <property type="nucleotide sequence ID" value="XM_625495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPY4"/>
    <dbReference type="GeneID" id="3372513"/>
    <dbReference type="KEGG" id="cpv:cgd8_320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_320"/>
    <dbReference type="InParanoid" id="Q5CPY4"/>
    <dbReference type="OMA" id="QECNNIC"/>
    <dbReference type="OrthoDB" id="342115at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="153"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="186"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="214"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="543" mass="61519" checksum="DC812B1AC9B74CCA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ48</accession>
    <name>Q5CQ48_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_4150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625578.1">
        <property type="nucleotide sequence ID" value="XM_625578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ48"/>
    <dbReference type="GeneID" id="3372530"/>
    <dbReference type="KEGG" id="cpv:cgd5_4150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4150"/>
    <dbReference type="InParanoid" id="Q5CQ48"/>
    <dbReference type="OMA" id="FRCKEDY"/>
    <dbReference type="OrthoDB" id="342748at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="783" mass="86493" checksum="EB021D33446A5BF3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQA2</accession>
    <name>Q5CQA2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_1500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625746.1">
        <property type="nucleotide sequence ID" value="XM_625746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQA2"/>
    <dbReference type="GeneID" id="3372706"/>
    <dbReference type="KEGG" id="cpv:cgd4_1500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1500"/>
    <dbReference type="InParanoid" id="Q5CQA2"/>
    <dbReference type="OMA" id="MIEIYIP"/>
    <dbReference type="OrthoDB" id="342866at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="125" mass="14670" checksum="77D0BDCDFB44094A" modified="2005-04-12" version="1">MVEIYASESSEVGKQVNWNYINKDSLSNINELDVTVLKEIYSEIIDFANKLAESNRIMEDYKDDEDIVDAIDENEGIIKRKKEIIELIESRFKQLNREDLINESKLEIDGKDCKNNEDNNMEEYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQE1</accession>
    <name>Q5CQE1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_1100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625707.1">
        <property type="nucleotide sequence ID" value="XM_625707.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQE1"/>
    <dbReference type="GeneID" id="3372678"/>
    <dbReference type="KEGG" id="cpv:cgd4_1100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1100"/>
    <dbReference type="InParanoid" id="Q5CQE1"/>
    <dbReference type="OMA" id="ICEQKEN"/>
    <dbReference type="OrthoDB" id="343140at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="555" mass="65011" checksum="0BC2587F82F998F3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQI9</accession>
    <name>Q5CQI9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase C subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625659.1">
        <property type="nucleotide sequence ID" value="XM_625659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQI9"/>
    <dbReference type="FunCoup" id="Q5CQI9">
        <property type="interactions" value="80"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQI9"/>
    <dbReference type="GeneID" id="3372728"/>
    <dbReference type="KEGG" id="cpv:cgd4_540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_540"/>
    <dbReference type="InParanoid" id="Q5CQI9"/>
    <dbReference type="OMA" id="VMIWIHV"/>
    <dbReference type="OrthoDB" id="6605928at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14785">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1460.10">
        <property type="entry name" value="subunit c (vma5p) of the yeast v-atpase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004907">
        <property type="entry name" value="ATPase_V1-cplx_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036132">
        <property type="entry name" value="Vac_ATP_synth_c_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10137:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03223">
        <property type="entry name" value="V-ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118203">
        <property type="entry name" value="Vacuolar ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="172"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="423" mass="47851" checksum="F50DF7022F9BCC4F" modified="2005-04-12" version="1">MGSSDSNKESQTQQYLIVACALTENSKDSIKDELIKSSKNISSNVSVLDFDVPFSLKFGAFDDLVKLVDDLAKHDTGVEVVLRRVERLGLELDPGMELRIIWQRSSYTIQQYLRSFSWDHAKFPKERSMKENLAALLQSVSKLDTDLRAKSAQFNEVKASVQNSFGKSATQGSSNSGNGAESGTSNTSGNNLIVVSGTLNTKDLTDVITPECIESGDIVDTEHIITVFVIVPKGNKENFLSSYESFDKYVVPKSAKFIKGITDKDGNEITRVLIFKSSVENFKTNCKNHKFTVRDDFKYSQEKYNHLMSTRQKLLQEKDKQEKYLKRMCFAGFSEIFISWIHVKAMRCFVEAVLRYGVPPQFASFMISMDSNQSKLKKVQNSVEKVFTEMGRIGATFKSNEKDVDDEYTPYVFLQFSPYQQSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQN0</accession>
    <name>Q5CQN0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sac1p family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_80</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625618.1">
        <property type="nucleotide sequence ID" value="XM_625618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQN0"/>
    <dbReference type="SMR" id="Q5CQN0"/>
    <dbReference type="FunCoup" id="Q5CQN0">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQN0"/>
    <dbReference type="GeneID" id="3372725"/>
    <dbReference type="KEGG" id="cpv:cgd4_80"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_80"/>
    <dbReference type="InParanoid" id="Q5CQN0"/>
    <dbReference type="OMA" id="FIYRINC"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043812">
        <property type="term" value="F:phosphatidylinositol-4-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662">
        <property type="entry name" value="PHOSPHATIDYLINOSITIDE PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45662:SF2">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-3-PHOSPHATASE SAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="710"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="739"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="787"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="domain" description="SAC" evidence="2">
        <location>
            <begin position="192"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="836" mass="96102" checksum="2CFF243B1D7CBFFA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQY9</accession>
    <name>Q5CQY9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNAj domain protein having a signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625863.1">
        <property type="nucleotide sequence ID" value="XM_625863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQY9"/>
    <dbReference type="FunCoup" id="Q5CQY9">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQY9"/>
    <dbReference type="GeneID" id="3372976"/>
    <dbReference type="KEGG" id="cpv:cgd4_2780"/>
    <dbReference type="InParanoid" id="Q5CQY9"/>
    <dbReference type="OMA" id="YDECETK"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000013">
        <property type="entry name" value="DnaJ subfamily B member 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044713">
        <property type="entry name" value="DNJA1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43888">
        <property type="entry name" value="DNAJ-LIKE-2, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254278" evidence="1">
        <location>
            <begin position="22"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="23"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="361" mass="40787" checksum="26D0D64CFB370296" modified="2005-04-12" version="1" fragment="single">EMRGLLIFLLFLFKLFDGTFGKSYYDILGIKKSASDTEIKKAYRQKSLKYHPDRNPSPDASEKFKEIATAYEVLADPEKRGIYDKFGEDGLKQHLEGFQSNDPFDLFSMGFGNLFGMGPGRGDGERYRVPDSTFKIFMTLEQLYFGEMITISFIRPVLCINANDCLKNRSDCAAAGTKLFTQQMGPGFMVQHQVNDPTCVARKKGWDKNCKQCPNGPTELETAKLTAYIDPGMYSGDKIRFEGSGEQKLNQEPGDFIIVIFEVENNKFKRVGNDLHTNLEITLADALLGFNLPLKYIDGKNINIEKNGITSFGDVLKVKNKGMPIRNTNEYGDLYVTLKFKMPSELNDAQKQLIRQAILDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR06</accession>
    <name>Q5CR06_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Oxysterol binding protein 1A-like pleckstrin homology (PH) domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_2580</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the OSBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625846.1">
        <property type="nucleotide sequence ID" value="XM_625846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR06"/>
    <dbReference type="FunCoup" id="Q5CR06">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="GeneID" id="3372849"/>
    <dbReference type="KEGG" id="cpv:cgd4_2580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2580"/>
    <dbReference type="InParanoid" id="Q5CR06"/>
    <dbReference type="OMA" id="PCDQNEG"/>
    <dbReference type="OrthoDB" id="1854502at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032934">
        <property type="term" value="F:sterol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120009">
        <property type="term" value="P:intermembrane lipid transfer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd13293">
        <property type="entry name" value="PH_CpORP2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.160.120:FF:000001">
        <property type="entry name" value="Oxysterol-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037239">
        <property type="entry name" value="OSBP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000648">
        <property type="entry name" value="Oxysterol-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972:SF205">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10972">
        <property type="entry name" value="OXYSTEROL-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01237">
        <property type="entry name" value="Oxysterol_BP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144000">
        <property type="entry name" value="Oxysterol-binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0445">Lipid transport</keyword>
    <keyword evidence="5" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="PH" evidence="6">
        <location>
            <begin position="95"/>
            <end position="188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="814" mass="95280" checksum="E47061C4F2A020C8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR32</accession>
    <name>Q5CR32_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_2310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625820.1">
        <property type="nucleotide sequence ID" value="XM_625820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR32"/>
    <dbReference type="GeneID" id="3372890"/>
    <dbReference type="KEGG" id="cpv:cgd4_2310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2310"/>
    <dbReference type="InParanoid" id="Q5CR32"/>
    <dbReference type="OrthoDB" id="337209at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="228" mass="26527" checksum="D4FD32AE9CECD35C" modified="2005-04-12" version="1">MSIIEEFNQLKRDLEALFSSKEMIEKQIREKALRIFMLNNECIYLSNNKEHTKNDVQEPYLEICNYISDILQVRLNSDSFVELKQCKANNRNITGKEEVRVVQHRISSLEDDQSENKKSLIHANSYAFKNIYNLDDFMNTTNWLWNKELKSKIVEVVSNRSNEFPNATKPSQIGGDFSSISLGHNKVHCNALPKLVCKTVKIEENNPEQTKHINPLKSYIEKAFKLES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR97</accession>
    <name>Q5CR97_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Chromodomain-helicase-DNA-binding'multidomain chromatin protein with the following architecture: chromo-bromo-chromo-SNF2 ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd4_1590</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625755.1">
        <property type="nucleotide sequence ID" value="XM_625755.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR97"/>
    <dbReference type="GeneID" id="3372930"/>
    <dbReference type="KEGG" id="cpv:cgd4_1590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1590"/>
    <dbReference type="InParanoid" id="Q5CR97"/>
    <dbReference type="OMA" id="CKWITED"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF11">
        <property type="entry name" value="KISMET, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 8" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="15" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="431"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Chromo" evidence="11">
        <location>
            <begin position="549"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="1354"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="1701"/>
            <end position="1857"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="119"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="207"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="257"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="662"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="721"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="839"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2031"/>
            <end position="2061"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="2082"/>
            <end position="2240"/>
        </location>
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    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1260"/>
            <end position="1287"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
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        <location>
            <begin position="119"/>
            <end position="134"/>
        </location>
    </feature>
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        <location>
            <begin position="212"/>
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        </location>
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        <location>
            <begin position="231"/>
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        </location>
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        <location>
            <begin position="262"/>
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        <location>
            <begin position="725"/>
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            <begin position="852"/>
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            <begin position="2036"/>
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        <location>
            <begin position="2052"/>
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            <begin position="2097"/>
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        </location>
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        <location>
            <begin position="2108"/>
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        </location>
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        <location>
            <begin position="2122"/>
            <end position="2135"/>
        </location>
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        <location>
            <begin position="2155"/>
            <end position="2173"/>
        </location>
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        <location>
            <begin position="2174"/>
            <end position="2197"/>
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        <location>
            <begin position="2223"/>
            <end position="2233"/>
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    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
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        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK87914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2270" mass="253406" checksum="32AA27F00B1C67DF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRA0</accession>
    <name>Q5CRA0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_1560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_625752.1"/>
    </dbReference>
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    <dbReference type="GeneID" id="3372911"/>
    <dbReference type="KEGG" id="cpv:cgd4_1560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1560"/>
    <dbReference type="InParanoid" id="Q5CRA0"/>
    <dbReference type="OrthoDB" id="344288at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="191" mass="21612" checksum="7770B45249D4CEB6" modified="2005-04-12" version="1">MSPLRGRKIRRIYINSEDNYNENSLSKINNGSYDDNYSRYNHYRKLSKLGGINLSEIGQVGVGVESVSGTEVASGSGMFIERGSGHLENPGNISNFNAVNLEEFTCSNKQVMNTGINDYRTNQGINIENISRDDVNMLKNSQENNMYIKNLNPMQLKYLQKTQKILSYELSSYKSGIKQLLSIPEYLPCDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRA9</accession>
    <name>Q5CRA9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">B-related factor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd5_3540</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TFIIB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_626277.1"/>
    </dbReference>
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    <dbReference type="STRING" id="353152.Q5CRA9"/>
    <dbReference type="GeneID" id="3373219"/>
    <dbReference type="KEGG" id="cpv:cgd5_3540"/>
    <dbReference type="InParanoid" id="Q5CRA9"/>
    <dbReference type="OMA" id="LYAICRR"/>
    <dbReference type="OrthoDB" id="511529at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000995">
        <property type="term" value="F:RNA polymerase III general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20553">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20554">
        <property type="entry name" value="CYCLIN_TFIIIB90_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000007">
        <property type="entry name" value="Transcription factor IIIB 90 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.650">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011665">
        <property type="entry name" value="BRF1_TBP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF4">
        <property type="entry name" value="TRANSCRIPTION FACTOR IIIB 90 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07741">
        <property type="entry name" value="BRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="13">
        <location>
            <begin position="4"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="324"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="503"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="577"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="329"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="348"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="511"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="577"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="599"/>
            <end position="608"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK88231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="648" mass="71644" checksum="3CDDF93C5E0600C3" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRC1</accession>
    <name>Q5CRC1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Possible phosphate/phosphoenolpyruvate translocator with 9 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_3410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626265.1">
        <property type="nucleotide sequence ID" value="XM_626265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRC1"/>
    <dbReference type="GeneID" id="3373054"/>
    <dbReference type="KEGG" id="cpv:cgd5_3410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3410"/>
    <dbReference type="InParanoid" id="Q5CRC1"/>
    <dbReference type="OMA" id="LFWEVPK"/>
    <dbReference type="OrthoDB" id="10261634at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="23"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="55"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="123"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="148"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="245"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="279"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="23"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="495" mass="55279" checksum="F8CE91338E957A59" modified="2005-04-12" version="1">MMDNQIKIEHGYGVKKAIESKHLVFLMWIVLSLIFTLYSKWLMNNYFPYPITMSLIHMIIASVLSHVFGGFVNKRFGDKSRFSSIGELSFQEKKSILAFSIIVALNIWFSNASLHLVSISLHQMARTTIPLFTMALGILFFKHKYRLSQIPPVILVIVGVAITVNGTPELSIYGLFIVFMGCCVSSLKGIVAQKLQVENLKINAIIMLQYVGPVASLTLGFFSVILGEAQKISKKSENMDKISFLMTNVLLIFAGILAFGLNILSLMSSSIVSPLAMNIAGNVKQLLTCLLGCFIFGNTVTDKLLLGILLTSLGALWYSLDKQKDSGKKKVRYVKGRYIDRVGLGIPNEMGTPHNKRVNNKNPSLESIEIKQIGDCNKTQIVQISKESESHLEEDVILELTNQIDGTEISLEDDHHISSKEVSCYLKMESIIEEEECQEIQVNLEPEGLEEVDNGDYTFKKIADLNNNMDIIVLESGAKSSQNLDENRDYSNIQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRH3</accession>
    <name>Q5CRH3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ARF like small GTpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_2770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626213.1">
        <property type="nucleotide sequence ID" value="XM_626213.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRH3"/>
    <dbReference type="STRING" id="353152.Q5CRH3"/>
    <dbReference type="GeneID" id="3373208"/>
    <dbReference type="KEGG" id="cpv:cgd5_2770"/>
    <dbReference type="InParanoid" id="Q5CRH3"/>
    <dbReference type="OMA" id="FRIVMPG"/>
    <dbReference type="OrthoDB" id="414781at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="20"/>
            <end position="27"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="27"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="262" mass="30275" checksum="6F6D2AB1DA020A46" modified="2005-04-12" version="1" fragment="single">KMFNLLRSAGKVGMNVIFTGITGSGKTTLLYSSLLGRFSEVPKLNPTESFNFERIMYLKKLLLVWDTSGHIAFINNLLPVMLSTIKFRAIVYVVNLLQGDKLIFDQINNEIRTLLYNQQLSDCRFCILFNTFGSNSDSWPRQPAEFASLLGLCYLPPQIDNRTKWFVVDTAKGFTDHGWRMAVEFILFGSIPNMPYYTNVPDFELTPIHYYHSQYDGKTPYGYNFRQYIPNDYINALYYQNLPPPADTKPKTSKFAKLFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRI3</accession>
    <name>Q5CRI3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626203.1">
        <property type="nucleotide sequence ID" value="XM_626203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRI3"/>
    <dbReference type="GeneID" id="3373222"/>
    <dbReference type="KEGG" id="cpv:cgd5_2660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2660"/>
    <dbReference type="InParanoid" id="Q5CRI3"/>
    <dbReference type="OMA" id="ITIAHTM"/>
    <dbReference type="OrthoDB" id="340604at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="368"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1273" mass="147422" checksum="DAF765C12B39C0CF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRJ5</accession>
    <name>Q5CRJ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_2540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat WDR6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626191.1">
        <property type="nucleotide sequence ID" value="XM_626191.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRJ5"/>
    <dbReference type="STRING" id="353152.Q5CRJ5"/>
    <dbReference type="GeneID" id="3373157"/>
    <dbReference type="KEGG" id="cpv:cgd5_2540"/>
    <dbReference type="InParanoid" id="Q5CRJ5"/>
    <dbReference type="OMA" id="LENICPC"/>
    <dbReference type="OrthoDB" id="338631at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051973">
        <property type="entry name" value="tRNA_Anticodon_Mtase-Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344">
        <property type="entry name" value="WD REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14344:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="210"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="265"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1117" mass="127457" checksum="9A75866D8F3A2653" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="140" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS01</accession>
    <name>Q5CS01_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="29">Calcium-dependent protein kinase 1</fullName>
            <ecNumber evidence="5">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="33" type="ORF">cgd5_820</name>
    </gene>
    <organism evidence="33 34">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="33 34" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="34">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="35" key="2">
        <citation type="submission" date="2009-12" db="PDB data bank">
            <title>Crystal structure of calcium binding domain of CpCDPK3, cgd5_820.</title>
            <authorList>
                <person name="Qiu W."/>
                <person name="Hutchinson A."/>
                <person name="Wernimont A."/>
                <person name="Walker J.R."/>
                <person name="Sullivan H."/>
                <person name="Lin Y.-H."/>
                <person name="Mackenzie F."/>
                <person name="Kozieradzki I."/>
                <person name="Cossar D."/>
                <person name="Schapira M."/>
                <person name="Senisterra G."/>
                <person name="Vedadi M."/>
                <person name="Arrowsmith C.H."/>
                <person name="Bountra C."/>
                <person name="Weigelt J."/>
                <person name="Edwards A.M."/>
                <person name="Bochkarev A."/>
                <person name="Hui R."/>
                <person name="Amani M."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.14 ANGSTROMS) OF 325-520 IN COMPLEX WITH CA(2+)</scope>
    </reference>
    <reference evidence="36" key="3">
        <citation type="submission" date="2010-01" db="PDB data bank">
            <title>Crystal structure of full length CpCDPK3 (cgd5_820) in complex with Ca2+ and AMPPNP.</title>
            <authorList>
                <person name="Qiu W."/>
                <person name="Hutchinson A."/>
                <person name="Wernimont A."/>
                <person name="Walker J.R."/>
                <person name="Sullivan H."/>
                <person name="Lin Y.-H."/>
                <person name="Mackenzie F."/>
                <person name="Kozieradzki I."/>
                <person name="Cossar D."/>
                <person name="Schapira M."/>
                <person name="Senisterra G."/>
                <person name="Vedadi M."/>
                <person name="Arrowsmith C.H."/>
                <person name="Bountra C."/>
                <person name="Weigelt J."/>
                <person name="Edwards A.M."/>
                <person name="Bochkarev A."/>
                <person name="Hui R."/>
                <person name="Amani M."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 42-517 IN COMPLEX WITH CA(2+) AND MG(2+)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="26">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Host cell membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="28">Parasitophorous vacuole membrane</location>
            <topology evidence="28">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="25">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="33">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="5"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626035.1">
        <property type="nucleotide sequence ID" value="XM_626035.1"/>
    </dbReference>
    <dbReference type="PDB" id="3L19">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.14 A"/>
        <property type="chains" value="A/B=325-520"/>
    </dbReference>
    <dbReference type="PDB" id="3LIJ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A=42-517"/>
    </dbReference>
    <dbReference type="PDBsum" id="3L19"/>
    <dbReference type="PDBsum" id="3LIJ"/>
    <dbReference type="AlphaFoldDB" id="Q5CS01"/>
    <dbReference type="SMR" id="Q5CS01"/>
    <dbReference type="FunCoup" id="Q5CS01">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS01"/>
    <dbReference type="GeneID" id="3373302"/>
    <dbReference type="KEGG" id="cpv:cgd5_820"/>
    <dbReference type="InParanoid" id="Q5CS01"/>
    <dbReference type="OMA" id="WFAMHAP"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CS01"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020005">
        <property type="term" value="C:symbiont-containing vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000398">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000001">
        <property type="entry name" value="Calmodulin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
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            <begin position="62"/>
            <end position="318"/>
        </location>
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    <feature type="domain" description="EF-hand" evidence="32">
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    </feature>
    <feature type="domain" description="EF-hand" evidence="32">
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    <feature type="domain" description="EF-hand" evidence="32">
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            <begin position="446"/>
            <end position="481"/>
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            <end position="515"/>
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        <ligand>
            <name>ATP</name>
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        <source>
            <dbReference type="ARBA" id="ARBA00060437"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00068067"/>
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    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="31">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="32">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="33">
        <source>
            <dbReference type="EMBL" id="EAK88255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="34">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
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    </evidence>
    <evidence type="ECO:0007829" key="35">
        <source>
            <dbReference type="PDB" id="3L19"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="36">
        <source>
            <dbReference type="PDB" id="3LIJ"/>
        </source>
    </evidence>
    <sequence length="523" mass="59759" checksum="AD894F2FF9C53E1D" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS04</accession>
    <name>Q5CS04_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Conserve protein having a signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd5_790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 92 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88153.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626032.1">
        <property type="nucleotide sequence ID" value="XM_626032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS04"/>
    <dbReference type="CAZy" id="GT92">
        <property type="family name" value="Glycosyltransferase Family 92"/>
    </dbReference>
    <dbReference type="GeneID" id="3373140"/>
    <dbReference type="KEGG" id="cpv:cgd5_790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_790"/>
    <dbReference type="InParanoid" id="Q5CS04"/>
    <dbReference type="OMA" id="FEASICI"/>
    <dbReference type="OrthoDB" id="2526284at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008166">
        <property type="entry name" value="Glyco_transf_92"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21461:SF69">
        <property type="entry name" value="GLYCOSYLTRANSFERASE FAMILY 92 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01697">
        <property type="entry name" value="Glyco_transf_92"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88153.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="548" mass="64545" checksum="C60CD1AF689EB315" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS35</accession>
    <name>Q5CS35_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative eukaryotic translation initiation factor 3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626001.1">
        <property type="nucleotide sequence ID" value="XM_626001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS35"/>
    <dbReference type="FunCoup" id="Q5CS35">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS35"/>
    <dbReference type="GeneID" id="3373181"/>
    <dbReference type="KEGG" id="cpv:cgd5_390"/>
    <dbReference type="InParanoid" id="Q5CS35"/>
    <dbReference type="OMA" id="EHITNKR"/>
    <dbReference type="OrthoDB" id="1938156at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071540">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3e"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043614">
        <property type="term" value="C:multi-eIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.860">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.10">
        <property type="entry name" value="UVR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027512">
        <property type="entry name" value="EIF3A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054711">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14005">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3, THETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22591">
        <property type="entry name" value="eIF3a_PCI_TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eIF3a PCI" evidence="6">
        <location>
            <begin position="8"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="eIF3a PCI" evidence="6">
        <location>
            <begin position="327"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="936"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="664"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="936"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="952"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="969"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1005"/>
            <end position="1030"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22591"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1030" mass="120436" checksum="DB8F2BE439C7C86E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS61</accession>
    <name>Q5CS61_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RRPp/PMC2 like exosome 3'-5' exoribonuclease subunit with an RNAseD domain and an HRDc domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_100</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625975.1">
        <property type="nucleotide sequence ID" value="XM_625975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS61"/>
    <dbReference type="FunCoup" id="Q5CS61">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS61"/>
    <dbReference type="GeneID" id="3373334"/>
    <dbReference type="KEGG" id="cpv:cgd5_100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_100"/>
    <dbReference type="InParanoid" id="Q5CS61"/>
    <dbReference type="OMA" id="FFWKMLK"/>
    <dbReference type="OrthoDB" id="2250022at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003727">
        <property type="term" value="F:single-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071044">
        <property type="term" value="P:histone mRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nuclear polyadenylation-dependent antisense transcript catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071036">
        <property type="term" value="P:nuclear polyadenylation-dependent snoRNA catabolic process"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071037">
        <property type="term" value="P:nuclear polyadenylation-dependent snRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06147">
        <property type="entry name" value="Rrp6p_like_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002562">
        <property type="entry name" value="3'-5'_exonuclease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045092">
        <property type="entry name" value="Rrp6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049559">
        <property type="entry name" value="Rrp6p-like_exo"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124:SF47">
        <property type="entry name" value="EXOSOME COMPONENT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12124">
        <property type="entry name" value="POLYMYOSITIS/SCLERODERMA AUTOANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01612">
        <property type="entry name" value="DNA_pol_A_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00474">
        <property type="entry name" value="35EXOc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HRDC" evidence="7">
        <location>
            <begin position="559"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="695"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="869"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="935"/>
            <end position="957"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="700"/>
            <end position="712"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="883"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="957" mass="109862" checksum="64560522A1A62D37" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS77</accession>
    <name>Q5CS77_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628190.1">
        <property type="nucleotide sequence ID" value="XM_628190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS77"/>
    <dbReference type="STRING" id="353152.Q5CS77"/>
    <dbReference type="GeneID" id="3371728"/>
    <dbReference type="KEGG" id="cpv:cgd1_3790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3790"/>
    <dbReference type="InParanoid" id="Q5CS77"/>
    <dbReference type="OMA" id="EECEDKY"/>
    <dbReference type="OrthoDB" id="342018at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="277"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="395"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="860"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1241"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="397"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="871"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="890"/>
            <end position="902"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1257"/>
            <end position="1272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1272" mass="145090" checksum="CA88808F6CF0B6B9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSC4</accession>
    <name>Q5CSC4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628143.1">
        <property type="nucleotide sequence ID" value="XM_628143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSC4"/>
    <dbReference type="GeneID" id="3371456"/>
    <dbReference type="KEGG" id="cpv:cgd1_3280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3280"/>
    <dbReference type="InParanoid" id="Q5CSC4"/>
    <dbReference type="OMA" id="RDFPILM"/>
    <dbReference type="OrthoDB" id="344116at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019341">
        <property type="entry name" value="Alpha/Gamma-adaptin-bd_p34"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14659:SF1">
        <property type="entry name" value="ALPHA- AND GAMMA-ADAPTIN-BINDING PROTEIN P34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="274"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="274"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="285"/>
            <end position="301"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="312" mass="37232" checksum="6E15E931804F9FB1" modified="2005-04-12" version="1">MLYVIGEYNKQKKFLSSLINHLQGKYENKEETTLPEEAKLPEKVKINTKYYTTEIQVQFWTINEYLALDYKNKNLYTKHEIITHTPILIPNPEAILLIFSKIDLNQNYHLLSLLDKRYHPSNHEITRICCIIYNNYEEIIKENDSLREKMIINCNQFNYEFIILVLDTNDIIKQDDLLFSFIEGTKRVTQALYCTHWKNMYKQQIAVPNLENNKHHDISQYQEQDLDNYLDNFEFLLSIMRKMTCDIKHLSDQERRERASNLICDLAKYLNLDDEDGNNDDTNDDNSNNDNFNDNNANYEYEYNDSDLVNSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSC7</accession>
    <name>Q5CSC7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628140.1">
        <property type="nucleotide sequence ID" value="XM_628140.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSC7"/>
    <dbReference type="GeneID" id="3371459"/>
    <dbReference type="KEGG" id="cpv:cgd1_3240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3240"/>
    <dbReference type="InParanoid" id="Q5CSC7"/>
    <dbReference type="OMA" id="FAYSMNT"/>
    <dbReference type="OrthoDB" id="342131at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043291">
        <property type="term" value="C:RAVE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052208">
        <property type="entry name" value="DmX-like/RAVE_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950:SF9">
        <property type="entry name" value="RABCONNECTIN-3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13950">
        <property type="entry name" value="RABCONNECTIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2744"/>
            <end position="2770"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2904"/>
            <end position="2927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2904"/>
            <end position="2916"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="3184" mass="372240" checksum="749EE3493C3183DC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSN5</accession>
    <name>Q5CSN5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible RAN guanine nucleotide release factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_1940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MOG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628032.1">
        <property type="nucleotide sequence ID" value="XM_628032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSN5"/>
    <dbReference type="FunCoup" id="Q5CSN5">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSN5"/>
    <dbReference type="GeneID" id="3371649"/>
    <dbReference type="KEGG" id="cpv:cgd1_1940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1940"/>
    <dbReference type="InParanoid" id="Q5CSN5"/>
    <dbReference type="OMA" id="EVYVHKF"/>
    <dbReference type="OrthoDB" id="10255285at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.10">
        <property type="entry name" value="Mog1/PsbP, alpha/beta/alpha sandwich"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007681">
        <property type="entry name" value="Mog1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016123">
        <property type="entry name" value="Mog1/PsbP_a/b/a-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15837:SF0">
        <property type="entry name" value="RAN GUANINE NUCLEOTIDE RELEASE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04603">
        <property type="entry name" value="Mog1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55724">
        <property type="entry name" value="Mog1p/PsbP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="185" mass="21465" checksum="22D9F1B43DA2536B" modified="2005-04-12" version="1">MEYTNRKLYGGAITLNIPKEFDDISNVRDVPDHQEVFVDGFSESSIIVEILDPIDFAGCRNVAEYYFMDISEFNSSLDTRIIYSEPLSTYSNDLEISKCFGNQKLDKRYPDGIRREELELYLLVLRVVSKKADIVISFNNPTGCAAVKKSLHTNTDDRRHTEKEIREIMDEILRSFIIKDYNLFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSP1</accession>
    <name>Q5CSP1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_1870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628026.1">
        <property type="nucleotide sequence ID" value="XM_628026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSP1"/>
    <dbReference type="GeneID" id="3371662"/>
    <dbReference type="KEGG" id="cpv:cgd1_1870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1870"/>
    <dbReference type="InParanoid" id="Q5CSP1"/>
    <dbReference type="OrthoDB" id="392870at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254481" evidence="3">
        <location>
            <begin position="18"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="429"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="486" mass="54575" checksum="18B5053CE3D19CBD" modified="2005-04-12" version="1">MDLLYLLFLSFLIYVNGIRNFPTLDVKEFRSNGLSHFGRVDVGKIDIIEANSLYESEEVLNKLVLATKRQQELKEKEINIKAAIGSNLHKLNAISELLQMLIEKTSIEINGVVTELKSTVKESEKTKNMFLVQQNYKVVPTKKLPLAEYSESELDTFSKFSAGGEYHGLDCPLSCSPSSCDNQPKEPTHCFKAETLKDGTFASNCVPFTNPKTLTCPKGFIRCALSQPSRGNLYEILKSTETSTENSIKTVNNKKRSIAISGRNMHQCLRLLVVSKKTSCNIENIFAAVDESRQLIIPNGNSVFPTIKGDVALFEDVQVKKAGKFQLCLLQFYQDPNISGGEGARIMGSDSIGELNVLNEDEEIREDLKSSSQKENTEVYEKDETIVGAGIKDEKGPSNQEEENEKKVVLENDDGNQLDDDKKKSHWGVFWYILPIILILFSSGAGFAYYYYLNNKEFVHSKIINLPYLSALFNVPNSITHENKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSU0</accession>
    <name>Q5CSU0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATM1-like ABC transporter with 6 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd1_1350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627977.1">
        <property type="nucleotide sequence ID" value="XM_627977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSU0"/>
    <dbReference type="STRING" id="353152.Q5CSU0"/>
    <dbReference type="GeneID" id="3371627"/>
    <dbReference type="KEGG" id="cpv:cgd1_1350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1350"/>
    <dbReference type="InParanoid" id="Q5CSU0"/>
    <dbReference type="OMA" id="VFHIIPI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18582">
        <property type="entry name" value="ABC_6TM_ATM1_ABCB7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24221:SF402">
        <property type="entry name" value="IRON-SULFUR CLUSTERS TRANSPORTER ABCB7, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="264"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="345"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="378"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="114"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="463"/>
            <end position="762"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="770" mass="87056" checksum="ABD37F8BA6B882BC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSV0</accession>
    <name>Q5CSV0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted secreted protein, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_1230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627967.1">
        <property type="nucleotide sequence ID" value="XM_627967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSV0"/>
    <dbReference type="GeneID" id="3371595"/>
    <dbReference type="KEGG" id="cpv:cgd1_1230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1230"/>
    <dbReference type="InParanoid" id="Q5CSV0"/>
    <dbReference type="OMA" id="HEITHIC"/>
    <dbReference type="OrthoDB" id="338146at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254485" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1065"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="746"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1065" mass="123695" checksum="47285CC112432D26" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSV2</accession>
    <name>Q5CSV2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627965.1">
        <property type="nucleotide sequence ID" value="XM_627965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSV2"/>
    <dbReference type="FunCoup" id="Q5CSV2">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="3371599"/>
    <dbReference type="KEGG" id="cpv:cgd1_1210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1210"/>
    <dbReference type="InParanoid" id="Q5CSV2"/>
    <dbReference type="OMA" id="YTFRITN"/>
    <dbReference type="OrthoDB" id="339643at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="562" mass="64843" checksum="25D89F78345E24D9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSW1</accession>
    <name>Q5CSW1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Phosphatidylserine synthase I (Serine-exchange enzyme I), 9x transmembrane domains</fullName>
            <ecNumber evidence="15">2.7.8.8</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd1_1110</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="12">Phospholipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.8" evidence="15"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627956.1">
        <property type="nucleotide sequence ID" value="XM_627956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSW1"/>
    <dbReference type="FunCoup" id="Q5CSW1">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSW1"/>
    <dbReference type="GeneID" id="3371606"/>
    <dbReference type="KEGG" id="cpv:cgd1_1110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1110"/>
    <dbReference type="InParanoid" id="Q5CSW1"/>
    <dbReference type="OMA" id="YMENCNS"/>
    <dbReference type="OrthoDB" id="10265393at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003882">
        <property type="term" value="F:CDP-diacylglycerol-serine O-phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106245">
        <property type="term" value="F:L-serine-phosphatidylethanolamine phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006659">
        <property type="term" value="P:phosphatidylserine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004277">
        <property type="entry name" value="PSS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15362:SF7">
        <property type="entry name" value="PHOSPHATIDYLSERINE SYNTHASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03034">
        <property type="entry name" value="PSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="419"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="269"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00025707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK88472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="455" mass="52998" checksum="50C5773C59D8A3B2" modified="2005-04-12" version="1">MSVLRNRYIPRMEEYNSSKSTGYMGFWASILLSIPVIILWVFSELFSRGLLFESLRMSSNMRVAYGVMAVVAITMVMSIHFLPSGTFRWPCYAFWKIIMGMNILYFMLLTFLLFQDTEHIRNTLVYIDPKLIEKVPEVNYAGNSCSIIDGSNGWFSNILPKIDMFVIAHFLGWMVKALILRNNFLVWFNSILFEWLEITLRHILPNFYECWWDHIILDIFGCNMIGIFLGNYIIKRFNMTRFNWHTCRNGLGGQEYDHKAGDSISNSKQSIKASKEVGSSSVNKKKQKSTSKPRLLKVKNFMYSLFKWPKILTTLRGLGSFLILTAIVQLIDLNYFFFKAEFNMPVSHWIFGLRTALLAISGASAVRELYETIARDSSIHFGKVSFQCWLIVVVIFTESLLCWRFSGNLRVDSFIPSNFIIYIWTFIFFILVVLYLFLTLKSFFQNFGPSDKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSX2</accession>
    <name>Q5CSX2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_1000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627945.1">
        <property type="nucleotide sequence ID" value="XM_627945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSX2"/>
    <dbReference type="GeneID" id="3371556"/>
    <dbReference type="KEGG" id="cpv:cgd1_1000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1000"/>
    <dbReference type="InParanoid" id="Q5CSX2"/>
    <dbReference type="OMA" id="FNTEEWC"/>
    <dbReference type="OrthoDB" id="339083at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="168"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="16"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="298" mass="34407" checksum="42FE15BF4BEABE61" modified="2005-04-12" version="1">MLDYDQEKNLFDEESISQLQTNKDQANIPQEEDEEELDNAIEVLVSEKKVWEAAFHAAKLEIEEKNSEIESLKKLLIERNQLEMQKEYNRNCNLLKGPFESKIDSNKAVVNSDSTSKISKSPEDYIFEEFINIALEETQILDDGDEFVSKLESSGDIEDAYRLIFRSFVELSLNNISQEQRIESLNEELNATQEAVQNLHKTIQDSQNSSKLVSVAYTSQIKSLQEDLLNACKDIDFWKQQCENLNKTDITSIQNEEVFSETNFQGFDPTEWCNLGSGINTMVQVETSPDSYWWFISF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTA3</accession>
    <name>Q5CTA3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626566.1">
        <property type="nucleotide sequence ID" value="XM_626566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTA3"/>
    <dbReference type="GeneID" id="3373703"/>
    <dbReference type="KEGG" id="cpv:cgd2_3820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3820"/>
    <dbReference type="InParanoid" id="Q5CTA3"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="108" mass="12653" checksum="F89D3961DC6ACFE1" modified="2005-04-12" version="1">MKKSVRVVYIICNSLKHYSIDTAIYICCIYSLLHYIRIIINIYIILNYSLKMIAQGHPTLSTSFGSISDYYISDNSNNKEQTELIEFSSSSTIYVESSFYHPKELYYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTC9</accession>
    <name>Q5CTC9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible RNA binding motif, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88675.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626540.1">
        <property type="nucleotide sequence ID" value="XM_626540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTC9"/>
    <dbReference type="STRING" id="353152.Q5CTC9"/>
    <dbReference type="GeneID" id="3373753"/>
    <dbReference type="KEGG" id="cpv:cgd2_3530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3530"/>
    <dbReference type="InParanoid" id="Q5CTC9"/>
    <dbReference type="OMA" id="MSEGSDM"/>
    <dbReference type="OrthoDB" id="344365at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="94"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="303"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="316"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="359"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88675.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="541" mass="61849" checksum="BA5FC774C11FDE83" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTD8</accession>
    <name>Q5CTD8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Telomerase reverse transcriptase</fullName>
            <ecNumber evidence="7">2.7.7.49</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Telomerase catalytic subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd2_3440</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6 7">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.49"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Chromosome</location>
            <location evidence="7">Telomere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the reverse transcriptase family. Telomerase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.49" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626531.1">
        <property type="nucleotide sequence ID" value="XM_626531.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTD8"/>
    <dbReference type="GeneID" id="3373758"/>
    <dbReference type="KEGG" id="cpv:cgd2_3440"/>
    <dbReference type="InParanoid" id="Q5CTD8"/>
    <dbReference type="OMA" id="HHISIMD"/>
    <dbReference type="OrthoDB" id="289721at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000333">
        <property type="term" value="C:telomerase catalytic core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003720">
        <property type="term" value="F:telomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070034">
        <property type="term" value="F:telomerase RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042162">
        <property type="term" value="F:telomeric DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007004">
        <property type="term" value="P:telomere maintenance via telomerase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021891">
        <property type="entry name" value="Telomerase_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003545">
        <property type="entry name" value="Telomerase_RT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12066:SF0">
        <property type="entry name" value="TELOMERASE REVERSE TRANSCRIPTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12009">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00975">
        <property type="entry name" value="Telomerase_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 7" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7 10" id="KW-0695">RNA-directed DNA polymerase</keyword>
    <keyword evidence="7" id="KW-0779">Telomere</keyword>
    <keyword evidence="1 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Telomerase ribonucleoprotein complex - RNA-binding" evidence="9">
        <location>
            <begin position="454"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1294"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1294"/>
            <end position="1327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1329"/>
            <end position="1344"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1474" mass="169981" checksum="002256F03FE3B6ED" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTI8</accession>
    <name>Q5CTI8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SYF2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_2810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">May be part of a spliceosome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SYF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626481.1">
        <property type="nucleotide sequence ID" value="XM_626481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTI8"/>
    <dbReference type="STRING" id="353152.Q5CTI8"/>
    <dbReference type="GeneID" id="3373472"/>
    <dbReference type="KEGG" id="cpv:cgd2_2810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2810"/>
    <dbReference type="InParanoid" id="Q5CTI8"/>
    <dbReference type="OrthoDB" id="408413at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013260">
        <property type="entry name" value="mRNA_splic_SYF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264">
        <property type="entry name" value="GCIP-INTERACTING PROTEIN P29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13264:SF5">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08231">
        <property type="entry name" value="SYF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="230" mass="27623" checksum="020BE76959735902" modified="2005-04-12" version="1">MIAEKKTNSSRHLLEFLFRSEDELRNNEKIETLNSLNTKVHSAMIFNMEIFRNERRKELDKLLKFSNEEFIESSALRTAKNDSKVEYTCDIRFGSTELWRIQRNSQKFENVTENNRIRTKNRKKGLISSTNKKIIFDREKYEQQMSELKANPERSEFLRTSHVPSDNDKNLLINQYIKNQRKRFISESIYIRPDIYHINQGNKKYNEKLDRAYHEYTSEIKQNLERGTAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTM9</accession>
    <name>Q5CTM9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dop1p family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_2360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the DOP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626440.1">
        <property type="nucleotide sequence ID" value="XM_626440.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTM9"/>
    <dbReference type="GeneID" id="3373507"/>
    <dbReference type="KEGG" id="cpv:cgd2_2360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2360"/>
    <dbReference type="InParanoid" id="Q5CTM9"/>
    <dbReference type="OMA" id="GLETCIA"/>
    <dbReference type="OrthoDB" id="297643at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006895">
        <property type="term" value="P:Golgi to endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040314">
        <property type="entry name" value="DOP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056457">
        <property type="entry name" value="DOP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007249">
        <property type="entry name" value="DOP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042">
        <property type="entry name" value="DOPEY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14042:SF24">
        <property type="entry name" value="PROTEIN DOPEY-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24598">
        <property type="entry name" value="DOP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04118">
        <property type="entry name" value="Dopey_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="DOP1 N-terminal" evidence="4">
        <location>
            <begin position="9"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="domain" description="DOP1-like C-terminal" evidence="5">
        <location>
            <begin position="1620"/>
            <end position="1824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00046326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1968" mass="226861" checksum="F6BD50EE9EEBDDD8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTQ1</accession>
    <name>Q5CTQ1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Probable ATP-dependent 6-phosphofructokinase</fullName>
            <shortName evidence="10">ATP-PFK</shortName>
            <shortName evidence="10">Phosphofructokinase</shortName>
            <ecNumber evidence="10">2.7.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Phosphohexokinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_2130</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.</text>
    </comment>
    <comment type="function">
        <text evidence="2">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>beta-D-fructose 6-phosphate + ATP = beta-D-fructose 1,6-bisphosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16109"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.11"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Tetramer of two alpha (regulatory) and two beta (catalytic) chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.11" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626418.1">
        <property type="nucleotide sequence ID" value="XM_626418.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CTQ1"/>
    <dbReference type="FunCoup" id="Q5CTQ1">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTQ1"/>
    <dbReference type="GeneID" id="3373525"/>
    <dbReference type="KEGG" id="cpv:cgd2_2130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2130"/>
    <dbReference type="InParanoid" id="Q5CTQ1"/>
    <dbReference type="OMA" id="FMAHYLG"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009749">
        <property type="term" value="P:response to glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.480">
        <property type="entry name" value="Phosphofructokinase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01980">
        <property type="entry name" value="Phosphofructokinase_II_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011183">
        <property type="entry name" value="PfpB_PPi_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005482">
        <property type="entry name" value="PRK07085.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43650">
        <property type="entry name" value="PYROPHOSPHATE--FRUCTOSE 6-PHOSPHATE 1-PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43650:SF1">
        <property type="entry name" value="PYROPHOSPHATE--FRUCTOSE 6-PHOSPHATE 1-PHOSPHOTRANSFERASE SUBUNIT BETA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="12">
        <location>
            <begin position="157"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="12">
        <location>
            <begin position="778"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1056"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="1056"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1079"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="289"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="229"/>
            <end position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="258"/>
            <end position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="287"/>
            <end position="289"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="334"/>
            <end position="336"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="395"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="540"/>
            <end position="543"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for substrate specificity; cannot use PPi as phosphoryl donor" evidence="10">
        <location>
            <position position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1426" mass="159661" checksum="48038B1425F71AC7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTT3</accession>
    <name>Q5CTT3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ING1 ike protein with an N-terminal globular domain and a PHD domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626386.1">
        <property type="nucleotide sequence ID" value="XM_626386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTT3"/>
    <dbReference type="GeneID" id="3373747"/>
    <dbReference type="KEGG" id="cpv:cgd2_1670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1670"/>
    <dbReference type="InParanoid" id="Q5CTT3"/>
    <dbReference type="OrthoDB" id="343439at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="117" mass="13584" checksum="A47936CB8E9480D4" modified="2005-04-12" version="1">MDQKELDEVAVSQQENEFDELLPYSKIAKILKLVTDKKFTKTSVKLIQSSTTKFIKEISELSEKQSRIRSKKLDKDQAVIIQKEDVISAIQKGGKKFSFANFSTEFLEDRFWNMEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTW7</accession>
    <name>Q5CTW7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane associated adenylyl cyclase with 6 transmembrane regions and an adenylyl cyclase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_1270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626352.1">
        <property type="nucleotide sequence ID" value="XM_626352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTW7"/>
    <dbReference type="STRING" id="353152.Q5CTW7"/>
    <dbReference type="GeneID" id="3373582"/>
    <dbReference type="KEGG" id="cpv:cgd2_1270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1270"/>
    <dbReference type="InParanoid" id="Q5CTW7"/>
    <dbReference type="OMA" id="WISINTA"/>
    <dbReference type="OrthoDB" id="60033at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43336:SF3">
        <property type="entry name" value="GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43336">
        <property type="entry name" value="OXYGEN SENSOR HISTIDINE KINASE RESPONSE REGULATOR DEVS/DOSS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="398"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="520"/>
            <end position="664"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="828" mass="94623" checksum="71A0888B20EBE0EE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU00</accession>
    <name>Q5CU00_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Cleavage of peptide bonds with very broad specificity.</text>
            <dbReference type="EC" id="3.4.25.1"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626319.1">
        <property type="nucleotide sequence ID" value="XM_626319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU00"/>
    <dbReference type="STRING" id="353152.Q5CU00"/>
    <dbReference type="MEROPS" id="T01.010"/>
    <dbReference type="GeneID" id="3373651"/>
    <dbReference type="KEGG" id="cpv:cgd2_860"/>
    <dbReference type="InParanoid" id="Q5CU00"/>
    <dbReference type="OMA" id="TFIYGYC"/>
    <dbReference type="OrthoDB" id="7854943at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019774">
        <property type="term" value="C:proteasome core complex, beta-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004298">
        <property type="term" value="F:threonine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03762">
        <property type="entry name" value="proteasome_beta_type_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000243">
        <property type="entry name" value="Pept_T1A_subB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF0">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE SUBUNIT HSLV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00141">
        <property type="entry name" value="PROTEASOME"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="6 8 9" id="KW-0647">Proteasome</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0888">Threonine protease</keyword>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="52"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600243-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="248" mass="27569" checksum="9A8C38E60A4ED4BF" modified="2005-04-12" version="1" fragment="single">NIFSHNLFCEPLWRNFELVCLINEFKISKKARTKDQKIMELDFLNGEIETGTTIVALKYKDGLVLAADGRTSTGPIIAFRAARKITQITDKVFMCRSGSAADTQIISRYVRRIVQDHELETGEDTKVKSVASVARLISYQNKEHLLADMIIAGMDPNGEFKVFRIPLGGTLIEGSYAISGSGSGYIYSMLDSKYHSEMDLDECKSFARDLVSHAMFRDSSSGGIIRIIVINKSGVEEFVVPGEDVPNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU31</accession>
    <name>Q5CU31_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Hypothetical coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_510</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HOP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626288.1">
        <property type="nucleotide sequence ID" value="XM_626288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU31"/>
    <dbReference type="STRING" id="353152.Q5CU31"/>
    <dbReference type="GeneID" id="3373382"/>
    <dbReference type="KEGG" id="cpv:cgd2_510"/>
    <dbReference type="InParanoid" id="Q5CU31"/>
    <dbReference type="OMA" id="NFKMATA"/>
    <dbReference type="OrthoDB" id="272266at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120231">
        <property type="term" value="C:DNA recombinase auxiliary factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120230">
        <property type="term" value="F:recombinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007129">
        <property type="term" value="P:homologous chromosome pairing at meiosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000709">
        <property type="term" value="P:meiotic joint molecule formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010774">
        <property type="term" value="P:meiotic strand invasion involved in reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010776">
        <property type="entry name" value="Hop2_WH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938:SF0">
        <property type="entry name" value="HOMOLOGOUS-PAIRING PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15938">
        <property type="entry name" value="TBP-1 INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07106">
        <property type="entry name" value="WHD_TBPIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Homologous-pairing protein 2 winged helix" evidence="8">
        <location>
            <begin position="176"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="249"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="53"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="7">
        <location>
            <begin position="101"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="133"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF07106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="302" mass="34394" checksum="8E7F7669E2F73170" modified="2005-04-12" version="1">MVKRSKEEGNNMEEEGTGLDETQQSKMEDDNMESKSQVRPSRNSRKVVKYTDFDDEDDELDDFESDFDEEMDFIDEGDEDSDDEDDENDLDLEEEEFEKGKKGKKSTTKKKGGESINSKPAKPKKQSSKESSVEDELESDDEDKSTKPAKKKKLSAPKNLTKRNVANSGGGSAAGDAGEAIFNYMKEQNRPYSVQNVVDNLHNVYSKKQVTDEMERLAVEGKFICKEYGKQKVYLVDQSDCKELNKDEMEALDKSISVCESELNDLEVRLKQLKQETRNISVPLTIDELEEKIMQENLKVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU56</accession>
    <name>Q5CU56_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">P-type ATpase3, 13 transmembrane regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd3_4140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626958.1">
        <property type="nucleotide sequence ID" value="XM_626958.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU56"/>
    <dbReference type="GeneID" id="3373892"/>
    <dbReference type="KEGG" id="cpv:cgd3_4140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4140"/>
    <dbReference type="InParanoid" id="Q5CU56"/>
    <dbReference type="OMA" id="KMEDCNV"/>
    <dbReference type="OrthoDB" id="289856at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF11">
        <property type="entry name" value="CATION-TRANSPORTING P-TYPE ATPASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="43"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="128"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="355"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="378"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="589"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="617"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1171"/>
            <end position="1194"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1200"/>
            <end position="1219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1240"/>
            <end position="1258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1295"/>
            <end position="1313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1325"/>
            <end position="1344"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1392"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="12">
        <location>
            <begin position="415"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1431" mass="161156" checksum="7C70DE9D78A074EA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU67</accession>
    <name>Q5CU67_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_4030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626947.1">
        <property type="nucleotide sequence ID" value="XM_626947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU67"/>
    <dbReference type="STRING" id="353152.Q5CU67"/>
    <dbReference type="GeneID" id="3374011"/>
    <dbReference type="KEGG" id="cpv:cgd3_4030"/>
    <dbReference type="InParanoid" id="Q5CU67"/>
    <dbReference type="OMA" id="NQWESTS"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF50">
        <property type="entry name" value="PROTEIN LIFEGUARD 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="165"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="188"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="226"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="254" mass="29247" checksum="C92ECA5CCBDAFDD4" modified="2005-04-12" version="1" fragment="single">LQRSAMASTNIHSRRNEDIDLESQEFESFSKSVRHGFIRRVYMLVALQVLFDLALSLMVINVPSLKLFMLRNLSVIKMTAFAFALISSLLFFFLYNYSNLLQNHSSKMAFFCIMTISEGVLLSLLALLVNTKYLLMALAFTSIIVISLTIFSFQTKYDFTSYQAFIFYGTIAFAVFSTIYMFFPTVRIIELIISPIAIFFFSFALVQTTQSIIGNGKQMIYEDDYVLGALLIHSYIIDIFIYILRFILAVFERN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU70</accession>
    <name>Q5CU70_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_4000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626944.1">
        <property type="nucleotide sequence ID" value="XM_626944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU70"/>
    <dbReference type="GeneID" id="3373903"/>
    <dbReference type="KEGG" id="cpv:cgd3_4000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4000"/>
    <dbReference type="InParanoid" id="Q5CU70"/>
    <dbReference type="OMA" id="QIAMWNG"/>
    <dbReference type="OrthoDB" id="338604at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="120" mass="14108" checksum="2902F15D9D1A32AE" modified="2005-04-12" version="1">MKEKEDSNISEKEKINSWLEKQILIWNGIPINKLSGKNKVSQLSSNIKVKNEDNLITDKCKETKKLDLDEKKKENIRQEISCSNTNKIEKNEKNQNGDMRLRFKDWSDLHNYLLVSMKQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU72</accession>
    <name>Q5CU72_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_3980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626942.1">
        <property type="nucleotide sequence ID" value="XM_626942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU72"/>
    <dbReference type="GeneID" id="3373900"/>
    <dbReference type="KEGG" id="cpv:cgd3_3980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3980"/>
    <dbReference type="InParanoid" id="Q5CU72"/>
    <dbReference type="OMA" id="MEMEMEX"/>
    <dbReference type="OrthoDB" id="343477at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050972">
        <property type="entry name" value="SDr-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403:SF14">
        <property type="entry name" value="OS05G0225800 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34403">
        <property type="entry name" value="TOL-PAL SYSTEM PROTEIN TOLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="307"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="799" mass="92212" checksum="B4ABC1CDC788F096" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU88</accession>
    <name>Q5CU88_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_3790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626926.1">
        <property type="nucleotide sequence ID" value="XM_626926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU88"/>
    <dbReference type="FunCoup" id="Q5CU88">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU88"/>
    <dbReference type="GeneID" id="3373930"/>
    <dbReference type="KEGG" id="cpv:cgd3_3790"/>
    <dbReference type="InParanoid" id="Q5CU88"/>
    <dbReference type="OMA" id="NRVWIDP"/>
    <dbReference type="OrthoDB" id="5407653at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01417">
        <property type="entry name" value="Ribosomal_L19e_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1200.240:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1650.10:FF:000001">
        <property type="entry name" value="Ribosomal protein L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1200.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1650.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035970">
        <property type="entry name" value="60S_ribosomal_eL19_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039547">
        <property type="entry name" value="Ribosomal_eL19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000196">
        <property type="entry name" value="Ribosomal_eL19_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015972">
        <property type="entry name" value="Ribosomal_eL19_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033935">
        <property type="entry name" value="Ribosomal_eL19_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057259">
        <property type="entry name" value="Ribosomal_L19e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057260">
        <property type="entry name" value="Ribosomal_L19e_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006343">
        <property type="entry name" value="PRK08570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01280">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25476">
        <property type="entry name" value="Ribosomal_L19e_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01416">
        <property type="entry name" value="Ribosomal_L19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48140">
        <property type="entry name" value="Ribosomal protein L19 (L19e)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL19" evidence="5">
        <location>
            <begin position="1"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="60"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="175" mass="20563" checksum="856C48844023028C" modified="2005-04-12" version="1" fragment="single">PLILQKRLAKEVLKCGANRVWLDPTEMDTISTANSRQSIRKLYKDGLILKKAVATHSRARISRVHEAKRKGRSMGLGKRRGTKDARRPEKVLWMRRQRVLRRLLRKYRESGKINKTMYKQFYLKSKGNQYKNKRVLIEAIHIAKAEHLKEKALQDQLDARKARAANLKQKRKVLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUD7</accession>
    <name>Q5CUD7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_3260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626877.1">
        <property type="nucleotide sequence ID" value="XM_626877.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUD7"/>
    <dbReference type="GeneID" id="3373869"/>
    <dbReference type="KEGG" id="cpv:cgd3_3260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3260"/>
    <dbReference type="InParanoid" id="Q5CUD7"/>
    <dbReference type="OrthoDB" id="10263185at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="252" mass="29319" checksum="3FDF39546E1AA785" modified="2005-04-12" version="1">MKSHSQTSKKLNKASKSKKVKLEIVTKMLLDLNKQISEARKATMEPIPIDILSMGDTDQSFSDFSRELLLDENKDVNESISSLKPLVHQFLKLSSIIMDNQYIGTEGIQINNDLGKCISSNRNNLRAVIVQIFMKWLKDDIMIRNYKNMKEKGNFDETGNFPISLSTFIIRSILTSSIQNNEINRIILDSRNNMTNDTFIMENLLLNEYITNFKDLRYFFLKNILNFLNKYSEGLIFNFGKKNESMIQWFNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUI5</accession>
    <name>Q5CUI5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DNAj domain, possible transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_2690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626829.1">
        <property type="nucleotide sequence ID" value="XM_626829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUI5"/>
    <dbReference type="STRING" id="353152.Q5CUI5"/>
    <dbReference type="GeneID" id="3373967"/>
    <dbReference type="KEGG" id="cpv:cgd3_2690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2690"/>
    <dbReference type="InParanoid" id="Q5CUI5"/>
    <dbReference type="OMA" id="SNKDCKD"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052448">
        <property type="entry name" value="DnaJ_C16_autophagy_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44303:SF2">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="99"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="631" mass="72944" checksum="9240CC050ADBD78B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUJ4</accession>
    <name>Q5CUJ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_2600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626820.1">
        <property type="nucleotide sequence ID" value="XM_626820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUJ4"/>
    <dbReference type="STRING" id="353152.Q5CUJ4"/>
    <dbReference type="GeneID" id="3373973"/>
    <dbReference type="KEGG" id="cpv:cgd3_2600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2600"/>
    <dbReference type="InParanoid" id="Q5CUJ4"/>
    <dbReference type="OMA" id="LEMCEST"/>
    <dbReference type="OrthoDB" id="344185at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1201" mass="140159" checksum="B656181F2354DED1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUJ5</accession>
    <name>Q5CUJ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_2580</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626819.1">
        <property type="nucleotide sequence ID" value="XM_626819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUJ5"/>
    <dbReference type="GeneID" id="3373974"/>
    <dbReference type="KEGG" id="cpv:cgd3_2580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2580"/>
    <dbReference type="InParanoid" id="Q5CUJ5"/>
    <dbReference type="OrthoDB" id="336256at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12276">
        <property type="entry name" value="RRM2_MEI2_EAR1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23189">
        <property type="entry name" value="RNA RECOGNITION MOTIF-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="75"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="159"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="394" mass="45136" checksum="387C2EB9925D0532" modified="2005-04-12" version="1">MFHLSRFWGKTTQHVSMFRSDPYSQSIASNNDNRLFLNSNHQNYSIQYQGASKNPCQHVITTDLDDPITETYISRTLYLCKLPYDMTEDSVRELCEPFGDLKKVAVYPRKGIAFVEYFDIRKAEGARNTLKSSLVQGRIIDAQYSRGRDGRPSRDTNTGTLYIKPIVSNKTATDPNTEDDYKELFCAYGEVKKVSSNRKRESEKFVEFYDIRGAEASQKALNGYDFNGVILEIQFANTHSRTLNSDSRATASSRNSGVCNKSLRISSEERYKQQSSLNTKKKYKPIKCGTSRVLKRLVARDASHCELYSEFSKRNVNRNDLRVHPDFRLLYQSSAPFQETNNLGEFGKFPIITQRPSDDSTRTGNIAESLKTLLSTFKHQKYDIECNNSKNNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUU3</accession>
    <name>Q5CUU3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">GAF domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_1460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626721.1">
        <property type="nucleotide sequence ID" value="XM_626721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUU3"/>
    <dbReference type="GeneID" id="3374031"/>
    <dbReference type="KEGG" id="cpv:cgd3_1460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1460"/>
    <dbReference type="InParanoid" id="Q5CUU3"/>
    <dbReference type="OMA" id="CYENIFV"/>
    <dbReference type="OrthoDB" id="74705at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029016">
        <property type="entry name" value="GAF-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55781">
        <property type="entry name" value="GAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="537" mass="61160" checksum="42947A45079DD5E2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUV5</accession>
    <name>Q5CUV5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 7">60S ribosomal export protein NMD3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd3_1340</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the NMD3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626709.1">
        <property type="nucleotide sequence ID" value="XM_626709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUV5"/>
    <dbReference type="STRING" id="353152.Q5CUV5"/>
    <dbReference type="GeneID" id="3373984"/>
    <dbReference type="KEGG" id="cpv:cgd3_1340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1340"/>
    <dbReference type="InParanoid" id="Q5CUV5"/>
    <dbReference type="OMA" id="VILVRKH"/>
    <dbReference type="OrthoDB" id="203821at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039768">
        <property type="entry name" value="Nmd3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007064">
        <property type="entry name" value="Nmd3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048899">
        <property type="entry name" value="NMD_SH3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048898">
        <property type="entry name" value="OB_NMD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746:SF2">
        <property type="entry name" value="60S RIBOSOMAL EXPORT PROTEIN NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12746">
        <property type="entry name" value="NONSENSE-MEDIATED MRNA DECAY PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04981">
        <property type="entry name" value="NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21193">
        <property type="entry name" value="NMD_SH3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21192">
        <property type="entry name" value="OB_NMD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Nmd3 N-terminal" evidence="9">
        <location>
            <begin position="47"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 SH3" evidence="11">
        <location>
            <begin position="276"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="60S ribosomal export protein NMD3 OB-fold" evidence="10">
        <location>
            <begin position="347"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="528"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009794"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00017035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF04981"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF21193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="588" mass="67662" checksum="1E5A555A191BA844" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUW6</accession>
    <name>Q5CUW6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hyaluronan/mRNA-binding protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626698.1">
        <property type="nucleotide sequence ID" value="XM_626698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUW6"/>
    <dbReference type="GeneID" id="3373992"/>
    <dbReference type="KEGG" id="cpv:cgd3_1220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1220"/>
    <dbReference type="InParanoid" id="Q5CUW6"/>
    <dbReference type="OMA" id="KKWAGAK"/>
    <dbReference type="OrthoDB" id="343064at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006861">
        <property type="entry name" value="HABP4_PAIRBP1-bd"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04774">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01233">
        <property type="entry name" value="HABP4_PAI-RBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hyaluronan/mRNA-binding protein" evidence="2">
        <location>
            <begin position="91"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="37"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="290" mass="32660" checksum="B794620474CD94C4" modified="2005-04-12" version="1">MRTVYTVNTRNKFAALSLSDDEDDQQIITKQEPVKSTAGNKENPSSLIYPKNEVTPNAPASALDTTSKMSRGARKGNTVHRGGRGGYTSSHGRVFDRRDASGKAHRVSKQNDSAGIEDEIIDKEKKYNNTNSSDVASNNQLDDNVADSEESQNKVDETKEKESQMISYEEYMKKMAPKRLEVPKTEIVKGNTTAKDFEKEGLQRYVRDDGSNTTTNKNNKNKANKNNTKSDKGVFNYFELVEKYTSRNSYNRRGNDDRRNRGNQRPNSSLQVRREAPDVSDTRAFPVLGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUY2</accession>
    <name>Q5CUY2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_1040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="1">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="1" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="1">Iowa type II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626682.1">
        <property type="nucleotide sequence ID" value="XM_626682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUY2"/>
    <dbReference type="GeneID" id="3374174"/>
    <dbReference type="KEGG" id="cpv:cgd3_1040"/>
    <dbReference type="InParanoid" id="Q5CUY2"/>
    <dbReference type="OrthoDB" id="341981at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="114" mass="13231" checksum="93E86ED3B282C976" modified="2005-04-12" version="1">MCNKLEIVINNNKATNYQNSDEIHTFQIYQNEQIKDNSTIKKEISSNTSQINFQDLSLLNDKLASLLFNKVSSSNNYCQQSFEKNNYGLTQSETIQFKRSIINLVNQMSKDFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV12</accession>
    <name>Q5CV12_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626652.1">
        <property type="nucleotide sequence ID" value="XM_626652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV12"/>
    <dbReference type="STRING" id="353152.Q5CV12"/>
    <dbReference type="GeneID" id="3374141"/>
    <dbReference type="KEGG" id="cpv:cgd3_670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_670"/>
    <dbReference type="InParanoid" id="Q5CV12"/>
    <dbReference type="OMA" id="AINICME"/>
    <dbReference type="OrthoDB" id="338458at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254980" evidence="1">
        <location>
            <begin position="25"/>
            <end position="582"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="582" mass="65776" checksum="1B572756DDF3F1F1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV52</accession>
    <name>Q5CV52_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_5390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627417.1">
        <property type="nucleotide sequence ID" value="XM_627417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV52"/>
    <dbReference type="GeneID" id="3374424"/>
    <dbReference type="KEGG" id="cpv:cgd8_5390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5390"/>
    <dbReference type="InParanoid" id="Q5CV52"/>
    <dbReference type="OrthoDB" id="344049at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="120"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="181" mass="20263" checksum="A0BFCEF87A2298E1" modified="2005-04-12" version="1">MGILMCLKSGIYFLVFSVLLTFSFNSINVFEYTAPSSNSDKLMFIQLRSSNEDKIKMPSNHKLRNSLGVSSSKSKSNSGNSLTSLNEFQEDHEPPEVPKRTVSLIPGRDPYKRGFEKPDQSPPPLPPRDPSIFQTSKGLEERVAEQLTVLDGILKEIESFGCVNIDSSEQNELLENDDVFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVD4</accession>
    <name>Q5CVD4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627335.1">
        <property type="nucleotide sequence ID" value="XM_627335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVD4"/>
    <dbReference type="GeneID" id="3374541"/>
    <dbReference type="KEGG" id="cpv:cgd8_4490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4490"/>
    <dbReference type="InParanoid" id="Q5CVD4"/>
    <dbReference type="OMA" id="ARARYTH"/>
    <dbReference type="OrthoDB" id="341550at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="400"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="744"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="408"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="773"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="803" mass="92604" checksum="8946882778D4E1FA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVI1</accession>
    <name>Q5CVI1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">NAP, nucleosome assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627288.1">
        <property type="nucleotide sequence ID" value="XM_627288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVI1"/>
    <dbReference type="FunCoup" id="Q5CVI1">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVI1"/>
    <dbReference type="GeneID" id="3374613"/>
    <dbReference type="KEGG" id="cpv:cgd8_3970"/>
    <dbReference type="InParanoid" id="Q5CVI1"/>
    <dbReference type="OMA" id="WPVALMN"/>
    <dbReference type="OrthoDB" id="19419at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051262">
        <property type="term" value="P:protein tetramerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.170.10">
        <property type="entry name" value="p53-like tetramerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036674">
        <property type="entry name" value="p53_tetramer_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="197" mass="23650" checksum="4041BA243102C03D" modified="2005-04-12" version="1" fragment="single">KLLVDTRLMELDSECAKEQMIIQRQFDEKKKPIFDERKAIIEKIPKFWADTISRHPVFQDNMHPEDFDILEYLKDIELEDNLDNEGSYKIKLIFDEAVSEFMEPNILVKHIIFKDNQEIVNEVTKINWKKESPRSIIEKKFIDTEENEEEYKNSVLSFFDFFSENISDDIDIGEIIRRDIYHAPLLYYREDDSISDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVJ0</accession>
    <name>Q5CVJ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Secreted alpha beta hydrolase family protein, signal peptide, duplicated adjacent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_3870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627279.1">
        <property type="nucleotide sequence ID" value="XM_627279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVJ0"/>
    <dbReference type="GeneID" id="3374257"/>
    <dbReference type="KEGG" id="cpv:cgd8_3870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3870"/>
    <dbReference type="InParanoid" id="Q5CVJ0"/>
    <dbReference type="OMA" id="PEENICY"/>
    <dbReference type="OrthoDB" id="17120at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016298">
        <property type="term" value="F:lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF57">
        <property type="entry name" value="BLR7027 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254554" evidence="5">
        <location>
            <begin position="20"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="116"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="4">
        <location>
            <begin position="322"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="482" mass="55101" checksum="B2FDF33D88D89E98" modified="2005-04-12" version="1">MKAVYLILYIFFIYQFVAAEAFTFRNRKEDERRELFSNFTQEIEKAQYLFEEIAVKNNNSMIFKLLTSQSDKEGYSPNIIDSNLSSYLNTPSEMICQIKNIPEFYYKSKEDKCYVLLLSGGANRGAWQTGVLRGLLGQHITKYNNTIRWDVIGGVSIGGILALAGLFHEPGEEFSYVKNLWNLWSNIRQDYLSDCTLPIWKNILKFATHYIGGLFGSKKKLRNSICDHTPLFFYLNDTFGHQIEPYKNKTYVKMKREMANNRTLKIKRREVLVSAVRYEDGEYISWNSSSTKLPDLINATLASTSVPGAFSPVLINGSHYMDGGVVMNMNIEHSIQACFKLGLAKRQEDVVIDAIETFPDTGPKVSDEESNTESQEITFTKLLSRSFSILHSQVRGLKLLKNVLCKYPKINLRYYISPTIEEYKQFPKNAFDGNNLTGILHMLRSGLHKGWSNNFTSVNECIFDSHGNPSNILGSELFSIDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVM3</accession>
    <name>Q5CVM3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627246.1">
        <property type="nucleotide sequence ID" value="XM_627246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVM3"/>
    <dbReference type="GeneID" id="3374290"/>
    <dbReference type="KEGG" id="cpv:cgd8_3530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3530"/>
    <dbReference type="InParanoid" id="Q5CVM3"/>
    <dbReference type="OrthoDB" id="337371at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253902" evidence="1">
        <location>
            <begin position="20"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="522" mass="60407" checksum="1FE88FA52D550FE8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVN2</accession>
    <name>Q5CVN2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Importin beta like ARM repeat alpha superhelix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_3440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89711.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627237.1">
        <property type="nucleotide sequence ID" value="XM_627237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVN2"/>
    <dbReference type="FunCoup" id="Q5CVN2">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVN2"/>
    <dbReference type="GeneID" id="3374618"/>
    <dbReference type="KEGG" id="cpv:cgd8_3440"/>
    <dbReference type="InParanoid" id="Q5CVN2"/>
    <dbReference type="OMA" id="AQEGAMS"/>
    <dbReference type="OrthoDB" id="951172at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89711.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="936" mass="103659" checksum="110592DFAF369120" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW40</accession>
    <name>Q5CW40_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">NEDD8-activating enzyme E1 catalytic subunit</fullName>
            <ecNumber evidence="4">6.2.1.64</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_1730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>ATP + [NEDD8 protein] + [E1 NEDD8-activating enzyme]-L-cysteine = AMP + diphosphate + [E1 NEDD8-activating enzyme]-S-[NEDD8 protein]-yl-L-cysteine.</text>
            <dbReference type="EC" id="6.2.1.64"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein neddylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.64" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627079.1">
        <property type="nucleotide sequence ID" value="XM_627079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW40"/>
    <dbReference type="FunCoup" id="Q5CW40">
        <property type="interactions" value="503"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW40"/>
    <dbReference type="GeneID" id="3374408"/>
    <dbReference type="KEGG" id="cpv:cgd8_1730"/>
    <dbReference type="InParanoid" id="Q5CW40"/>
    <dbReference type="OMA" id="PYLENYM"/>
    <dbReference type="OrthoDB" id="10255449at2759"/>
    <dbReference type="UniPathway" id="UPA00885"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019781">
        <property type="term" value="F:NEDD8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045116">
        <property type="term" value="P:protein neddylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF6">
        <property type="entry name" value="NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="5">
        <location>
            <begin position="50"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU368009"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="346" mass="38984" checksum="B7AE90E0DEFD4C5D" modified="2005-04-12" version="1" fragment="single">KFGEFFFVKFLLKLIAPPQLSTFSFIYTPQHGKAIMNSECKTLEKDIGLAYCKVLLVGVGGIGTEILRCLIFSGFRRIDIVDYDYVEVSNISRQLFFNLGDEGKSKVHVLAANATNHFKSAKGLEIKPFHSDISDFFSKFNVTPSDYKIILSGLDNIHARRTLNAIVMTQSSPQAYPILLDSGTEGFNGHSRIIIPGETSCYECTMGLNVQDTNFPLCEIKEFPRTPIHCIAYANFIYEEDEQDNEDFKNHKILKIYQLAQEHAKSFGIQGVTLELTKQIIGNIFPTLLSTNTIIASSVVSQAIKYLRGSGQAKNLKNYFMYYGQTGIYSSCFEIHKDENCIFCKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW57</accession>
    <name>Q5CW57_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">YLR387c-like protein with 2x C2H2 like zinc fingers conserved across eukaryotes plus an apicomplexan-specific globular domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627062.1">
        <property type="nucleotide sequence ID" value="XM_627062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW57"/>
    <dbReference type="STRING" id="353152.Q5CW57"/>
    <dbReference type="GeneID" id="3374403"/>
    <dbReference type="KEGG" id="cpv:cgd8_1550"/>
    <dbReference type="InParanoid" id="Q5CW57"/>
    <dbReference type="OMA" id="SHMICKS"/>
    <dbReference type="OrthoDB" id="19329at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040025">
        <property type="entry name" value="Znf622/Rei1/Reh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182:SF8">
        <property type="entry name" value="CYTOPLASMIC 60S SUBUNIT BIOGENESIS FACTOR ZNF622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13182">
        <property type="entry name" value="ZINC FINGER PROTEIN 622"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="14"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="165"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="392" mass="46469" checksum="492B53E424838A9F" modified="2005-04-12" version="1" fragment="single">SKSLEEMQNVSALCTVCDYKLDSTSLLREHYKTEWHNYNQKRKLANKDPVSEIAFKRKLELLECTKVVVNKGSSHIKNKQKIDGQENYKMNESVSVDMNQDKPRQSDTYELTYCYFDNTIHSSMEECFEYMRIKYSFVIPDKEYLVDYKGLAQYLGEKLFEGHICLYCDKIFSSLRAVRDHMISLGHTMLGTHLDIQKEELESFYNYSLSYKELIPNFNKLSITDDVLKEENNDDWEYIDEEEEEDDDDDDFSGNTNEIRKLNKKEMTLDEILSMYNLSKPEITEFGDLRLPNGKEVVHRNLAYIYKQRIPRKHQFEMEDGNNSTLVLKNRHHNKKINIYGNNQFGLNLKFKDKSHLKQNLLLSKRIKNVNLKVGVNNNKLQKYFVRRDVVW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW89</accession>
    <name>Q5CW89_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd8_1230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627030.1">
        <property type="nucleotide sequence ID" value="XM_627030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW89"/>
    <dbReference type="STRING" id="353152.Q5CW89"/>
    <dbReference type="GeneID" id="3374263"/>
    <dbReference type="KEGG" id="cpv:cgd8_1230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1230"/>
    <dbReference type="InParanoid" id="Q5CW89"/>
    <dbReference type="OMA" id="AEESNHY"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF23">
        <property type="entry name" value="TOUSLED-LIKE KINASE, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="440"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="288"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="121"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="292"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="730" mass="84017" checksum="E2D4EB9953B7C438" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW99</accession>
    <name>Q5CW99_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_1130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627020.1">
        <property type="nucleotide sequence ID" value="XM_627020.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW99"/>
    <dbReference type="GeneID" id="3374567"/>
    <dbReference type="KEGG" id="cpv:cgd8_1130"/>
    <dbReference type="InParanoid" id="Q5CW99"/>
    <dbReference type="OrthoDB" id="10490400at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="127" mass="15076" checksum="55DDAF523189A4DC" modified="2005-04-12" version="1">MESINKRSNRIELALDDWAKLVKKSYSVEIDQIKKKHSKILNQYKPDRTIYMENVLSYQYTKNICLLASEIIRRNGVSYLIIDFLKQMLFLRGFFALTKDSILMQLTRFSTYMKLVEVSFPIIILIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWD5</accession>
    <name>Q5CWD5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Prefoldin like molecular chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNA polymerase II subunit 5-mediating protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626984.1">
        <property type="nucleotide sequence ID" value="XM_626984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWD5"/>
    <dbReference type="STRING" id="353152.Q5CWD5"/>
    <dbReference type="GeneID" id="3374519"/>
    <dbReference type="KEGG" id="cpv:cgd8_740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_740"/>
    <dbReference type="InParanoid" id="Q5CWD5"/>
    <dbReference type="OMA" id="KEMDHIN"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019212">
        <property type="term" value="F:phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23159">
        <property type="entry name" value="Prefoldin_URI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052255">
        <property type="entry name" value="RNA_pol_II_subunit5-mediator"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15111:SF0">
        <property type="entry name" value="UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="248" mass="28686" checksum="C506D01C7B4D687D" modified="2005-04-12" version="1">MVITDSSVIYKNKEILENEISELNSMISEFQQVSQVLNRLPNKVQHEIMVPLGPLAFSPGYIINTNKVLMLLGSDLYAERTTFESQKTIKRRLSQAEDCLETMKKNLSKIEEALKLKDEFSIDIKESQAKEAEIKEENNKDHIFHKNITFTDGTAEIREEIDEDIDISKSFIPPPLFSCMDQKPYIPDSHVEDQDSRLEQDFIEEKEDTRVEILETEISNLNILQDTKTSANKTRPISIFKQRMAEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWE1</accession>
    <name>Q5CWE1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ABC transporter, AAA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_5450</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_627863.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWE1"/>
    <dbReference type="FunCoup" id="Q5CWE1">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWE1"/>
    <dbReference type="GeneID" id="3375923"/>
    <dbReference type="KEGG" id="cpv:cgd6_5450"/>
    <dbReference type="InParanoid" id="Q5CWE1"/>
    <dbReference type="OMA" id="WMFFAIS"/>
    <dbReference type="OrthoDB" id="184675at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043926">
        <property type="entry name" value="ABCG_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19055">
        <property type="entry name" value="ABC2_membrane_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="388"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="482"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="519"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="546"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="621"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="36"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="653" mass="73614" checksum="8B7C70C612FD62E3" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWI8</accession>
    <name>Q5CWI8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">F11M21.28-like protein with 3 CCCH RNA binding domains, involved in RNA metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_4910</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627816.1">
        <property type="nucleotide sequence ID" value="XM_627816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWI8"/>
    <dbReference type="GeneID" id="3375814"/>
    <dbReference type="KEGG" id="cpv:cgd6_4910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4910"/>
    <dbReference type="InParanoid" id="Q5CWI8"/>
    <dbReference type="OMA" id="NNDITEH"/>
    <dbReference type="OrthoDB" id="20534at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045234">
        <property type="entry name" value="Unkempt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493:SF50">
        <property type="entry name" value="RING FINGER PROTEIN UNKEMPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493">
        <property type="entry name" value="UNKEMPT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="52"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="202"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="587" mass="66964" checksum="FEDC436AA0604FB5" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWL7</accession>
    <name>Q5CWL7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myosin'myosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_4560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90169.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627787.1">
        <property type="nucleotide sequence ID" value="XM_627787.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWL7"/>
    <dbReference type="GeneID" id="3375914"/>
    <dbReference type="KEGG" id="cpv:cgd6_4560"/>
    <dbReference type="InParanoid" id="Q5CWL7"/>
    <dbReference type="OMA" id="DLCELTH"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14888">
        <property type="entry name" value="MYSc_Myo27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Myosin motor" evidence="10">
        <location>
            <begin position="120"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="1886"/>
            <end position="1924"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="7">
        <location>
            <begin position="764"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1144"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1069"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1155"/>
            <end position="1166"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="213"/>
            <end position="220"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK90169.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1924" mass="217445" checksum="21570BBE1A0CEB1A" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWX9</accession>
    <name>Q5CWX9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CCCH+ringfinger domains protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_3300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627675.1">
        <property type="nucleotide sequence ID" value="XM_627675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWX9"/>
    <dbReference type="FunCoup" id="Q5CWX9">
        <property type="interactions" value="152"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWX9"/>
    <dbReference type="GeneID" id="3375895"/>
    <dbReference type="KEGG" id="cpv:cgd6_3300"/>
    <dbReference type="InParanoid" id="Q5CWX9"/>
    <dbReference type="OMA" id="FSLIRIM"/>
    <dbReference type="OrthoDB" id="25761at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034247">
        <property type="term" value="P:snoRNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16539">
        <property type="entry name" value="RING-HC_RNF113A_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039971">
        <property type="entry name" value="CWC24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930:SF0">
        <property type="entry name" value="RING FINGER PROTEIN 113B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12930">
        <property type="entry name" value="ZINC FINGER PROTEIN 183"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="231"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="151"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="291"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="293"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="311" mass="36206" checksum="00C404AE84B4125C" modified="2005-04-12" version="1" fragment="single">SRKELKYLNSFSFSLIRIMFKKRNVSKEQIRKIQNDNFEENQPKTLEERTFQGSLNTDIDEIKKRNLLKKDSDLVKDSDFEKDEKLDELVTIFSHKNNRKFSRDNIVNNYDLDLHDPNPPKKETSKSIYSEKKYDTLESRNPNIKLTLMIDYQHDICKDFKETGYCGFGDTCKFLHDRSDFKSGWKLDKEWEIEQKKKRLKIESISKDKSSIGDGNLSSNSTNNNKLPKKCSICNKKWKSDSNPVVTLCNHYFCEKCAFSHYTNTSKCFQCGLPTKGTFNIASIPQELISESDSYHSSESDSNHSENSQSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX18</accession>
    <name>Q5CX18_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627636.1">
        <property type="nucleotide sequence ID" value="XM_627636.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX18"/>
    <dbReference type="GeneID" id="3376160"/>
    <dbReference type="KEGG" id="cpv:cgd6_2880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2880"/>
    <dbReference type="InParanoid" id="Q5CX18"/>
    <dbReference type="OrthoDB" id="338811at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="340" mass="39899" checksum="9209C9563F8D3FFA" modified="2005-04-12" version="1">MEDNSGLINEKDFILKSRLEVKLNDLEKRHLETKEREAQTVGFLERKLRQVELEHKTELKLRRQLRYEVNNLRKKLLETYQLYSNTLEHNELMRSEIDRLKGDSLKSKCRQVDLAVSRQVEIEINELFQNDCYFNNENSRFEKKNRLNLRGLNEFDLKESRLSMSFDARNGRHSFNRGLPSRKNSFFGINRTAERIKIPSDGRTLGKAISGNESSKDLNLKSERAKDWLNQIEELYKPLEYPKLCNRMYKNELDSFSGIGIVDNSLNMGEDSLSDEEYYSGEYDVSENTEDVITNTGFIIDQINQQDKELSTLLNKTFISANKNRTASKNKLRNSRSNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX24</accession>
    <name>Q5CX24_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">2 SAM dependent methyltransferase S-adenosyl-L-methionine-dependent methyltransferases + spermidine synthase (SAM dependent methyltransferase)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_2820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627630.1">
        <property type="nucleotide sequence ID" value="XM_627630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX24"/>
    <dbReference type="STRING" id="353152.Q5CX24"/>
    <dbReference type="GeneID" id="3376155"/>
    <dbReference type="KEGG" id="cpv:cgd6_2820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2820"/>
    <dbReference type="InParanoid" id="Q5CX24"/>
    <dbReference type="OMA" id="FEWYGAF"/>
    <dbReference type="OrthoDB" id="411785at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051419">
        <property type="entry name" value="Lys/N-term_MeTrsfase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176:SF78">
        <property type="entry name" value="EEF1A LYSINE AND N-TERMINAL METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12176">
        <property type="entry name" value="SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01564">
        <property type="entry name" value="Spermine_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="4" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="5">
        <location>
            <begin position="58"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008361"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="697" mass="80024" checksum="5E6F91CBDC0F82BC" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX32</accession>
    <name>Q5CX32_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low complexity protein, possible apicomplexan conserved</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_2700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89908.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627622.1">
        <property type="nucleotide sequence ID" value="XM_627622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX32"/>
    <dbReference type="STRING" id="353152.Q5CX32"/>
    <dbReference type="GeneID" id="3376148"/>
    <dbReference type="KEGG" id="cpv:cgd6_2700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2700"/>
    <dbReference type="InParanoid" id="Q5CX32"/>
    <dbReference type="OMA" id="NIRDSAK"/>
    <dbReference type="OrthoDB" id="2274644at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031499">
        <property type="term" value="C:TRAMP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043634">
        <property type="term" value="P:polyadenylation-dependent ncRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054708">
        <property type="entry name" value="MTPAP-like_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045862">
        <property type="entry name" value="Trf4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092:SF15">
        <property type="entry name" value="INACTIVE NON-CANONICAL POLY(A) RNA POLYMERASE PROTEIN TRF4-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23092">
        <property type="entry name" value="POLY(A) RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22600">
        <property type="entry name" value="MTPAP-like_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Poly(A) RNA polymerase mitochondrial-like central palm" evidence="2">
        <location>
            <begin position="105"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF22600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89908.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="857" mass="97540" checksum="96A8587DCFBA55A1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXA6</accession>
    <name>Q5CXA6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cdc123p-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CDC123 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627548.1">
        <property type="nucleotide sequence ID" value="XM_627548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXA6"/>
    <dbReference type="STRING" id="353152.Q5CXA6"/>
    <dbReference type="GeneID" id="3376062"/>
    <dbReference type="KEGG" id="cpv:cgd6_1830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1830"/>
    <dbReference type="InParanoid" id="Q5CXA6"/>
    <dbReference type="OMA" id="TIRCENY"/>
    <dbReference type="OrthoDB" id="360540at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009772">
        <property type="entry name" value="CDC123"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323:SF6">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 123 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15323">
        <property type="entry name" value="D123 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07065">
        <property type="entry name" value="D123"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="491" mass="57706" checksum="1967AE898BFB4BDA" modified="2005-04-12" version="1">MHLYGSNHTKNAFSLGNTRSFVKSILANDYRLEFFLNDTYRLDNKYVPGELRGIINCERINIDEEHLMINHSVFSLKKHVFLLLKLKIDKKNKIIQLFPIEIKYSQNEKNEYSLIEELIVENNIEIADPISILEKNFDYFHLNEALENLFTPNLDSLMDFIFFIWAADDEFWDKNKLCDMGISKWYERLSNYKSKVTIDGILFNIPDSLILEYFELDGFDINYEALSESSRKCLEDINKSIRENTEFFSMGFSPKFTWSAPTDATWINSNRSICCRTLEELFILLKASTKVSEDIDRAKEGNISNVLLLREYVPTLNEMFEFRVFIGGCSLHSEYKILGISQRHICYYYKELSENFKLRTDIKSCIMEFFLYSKKELILELFDIFNSMCIAFDIYISNYKDKLSILIIDVQPLLHASPLLFNLFELKLNLLTEEGTELGFDILRTTENNSTKNMINNSYLKGFVPDELLSVSNSDFYNNETLDKLEWIDYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXG0</accession>
    <name>Q5CXG0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">GTpase Grc3p-like Pre-mRNA cleavage complex</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_1230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Clp1 family. NOL9/GRC3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89805.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627494.1">
        <property type="nucleotide sequence ID" value="XM_627494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXG0"/>
    <dbReference type="STRING" id="353152.Q5CXG0"/>
    <dbReference type="GeneID" id="3376037"/>
    <dbReference type="KEGG" id="cpv:cgd6_1230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1230"/>
    <dbReference type="InParanoid" id="Q5CXG0"/>
    <dbReference type="OMA" id="CICRETE"/>
    <dbReference type="OrthoDB" id="2405412at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF3">
        <property type="entry name" value="POLYNUCLEOTIDE 5'-HYDROXYL-KINASE NOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Clp1 P-loop" evidence="6">
        <location>
            <begin position="36"/>
            <end position="169"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89805.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="429" mass="49165" checksum="D019CAC63BE58455" modified="2005-04-12" version="1">MDKDFDYPLDWREFLNRILQESSKCRSKITSVLLIGPKNSGKTTFCLKIAKEFLNNKSYLNNNIYILDCDLGQPLVSPMSCVKLVKWDIEDICIGNSKNINISPEVMFYIGGNSPITHPLRYIKGLKQCFEYIKSIEEDNIILILNMPGWITGVGLEISSIITAFSIDISNNVYIGFTREFEPNTNNSEDNFSSMTSFYSFPVFDLNLVKNIKNEEFSIDNQLKTRIFVNTLSNLYSNIEIREIKKNVNPLIFFNEYMGYYLSKKHIPQYFCKTVHFPFSTVCIIPCPSTTLASEELKLHIPARLTNSIVALCIFNDEKHNFIPDLSEEDQKFNILETRILLPCIGFGIVHHINYQLKNVVITAPCWIPSSTLSKVNALQLTEMMLPQNYSFSTSKPYICNKRFLVKGISSGGKVPSSRKNLKRKIHNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXJ7</accession>
    <name>Q5CXJ7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627457.1">
        <property type="nucleotide sequence ID" value="XM_627457.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXJ7"/>
    <dbReference type="GeneID" id="3376082"/>
    <dbReference type="KEGG" id="cpv:cgd6_830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_830"/>
    <dbReference type="InParanoid" id="Q5CXJ7"/>
    <dbReference type="OrthoDB" id="48057at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264:SF3">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="130"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="704"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="808"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1606"/>
            <end position="1625"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1648"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2034"/>
            <end position="2063"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2422"/>
            <end position="2483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="353"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="704"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="738"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="815"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1648"/>
            <end position="1661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1670"/>
            <end position="1745"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2038"/>
            <end position="2060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2422"/>
            <end position="2443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2451"/>
            <end position="2482"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="3021" mass="329811" checksum="DC54881BFF9F8D9C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXM2</accession>
    <name>Q5CXM2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Phosphodiesterase</fullName>
            <ecNumber evidence="6">3.1.4.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="6">Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the cyclic nucleotide phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.-" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627432.1">
        <property type="nucleotide sequence ID" value="XM_627432.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CXM2"/>
    <dbReference type="STRING" id="353152.Q5CXM2"/>
    <dbReference type="GeneID" id="3376045"/>
    <dbReference type="KEGG" id="cpv:cgd6_500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_500"/>
    <dbReference type="InParanoid" id="Q5CXM2"/>
    <dbReference type="OMA" id="HNNTMFA"/>
    <dbReference type="OrthoDB" id="342865at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00077">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003607">
        <property type="entry name" value="HD/PDEase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023088">
        <property type="entry name" value="PDEase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023174">
        <property type="entry name" value="PDEase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00387">
        <property type="entry name" value="PDIESTERASE1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00471">
        <property type="entry name" value="HDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00126">
        <property type="entry name" value="PDEASE_I_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 5 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PDEase" evidence="9">
        <location>
            <begin position="1469"/>
            <end position="1841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="587"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1278"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1435"/>
            <end position="1455"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="1331"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1278"/>
            <end position="1320"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="3">
        <location>
            <position position="1552"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <begin position="1552"/>
            <end position="1556"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="1556"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="1592"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="1593"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="1593"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="1593"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="1746"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="1746"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="1798"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR623088-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU363067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1967" mass="227594" checksum="E82C83439CBBC3BA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXS0</accession>
    <name>Q5CXS0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Deoxyuridine 5'-triphosphate nucleotidohydrolase</fullName>
            <shortName evidence="5">dUTPase</shortName>
            <ecNumber evidence="5">3.6.1.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">dUTP pyrophosphatase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_5170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in nucleotide metabolism via production of dUMP, the immediate precursor of thymidine nucleotides, and decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>dUTP + H2O = dUMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10248"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61555"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="3.6.1.23"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1 5">Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the dUTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.23" evidence="5"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628660.1">
        <property type="nucleotide sequence ID" value="XM_628658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXS0"/>
    <dbReference type="FunCoup" id="Q5CXS0">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXS0"/>
    <dbReference type="GeneID" id="3372091"/>
    <dbReference type="KEGG" id="cpv:cgd7_5170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5170"/>
    <dbReference type="InParanoid" id="Q5CXS0"/>
    <dbReference type="OMA" id="MHLKIMC"/>
    <dbReference type="OrthoDB" id="419889at2759"/>
    <dbReference type="UniPathway" id="UPA00610">
        <property type="reaction ID" value="UER00666"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004170">
        <property type="term" value="F:dUTP diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006226">
        <property type="term" value="P:dUMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046081">
        <property type="term" value="P:dUTP catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07557">
        <property type="entry name" value="trimeric_dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.40.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008181">
        <property type="entry name" value="dUTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029054">
        <property type="entry name" value="dUTPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036157">
        <property type="entry name" value="dUTPase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033704">
        <property type="entry name" value="dUTPase_trimeric"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11241:SF0">
        <property type="entry name" value="DEOXYURIDINE 5'-TRIPHOSPHATE NUCLEOTIDOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00692">
        <property type="entry name" value="dUTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51283">
        <property type="entry name" value="dUTPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0546">Nucleotide metabolism</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="dUTPase-like" evidence="6">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="176" mass="19425" checksum="6CE4BDBA8F4E85B1" modified="2005-04-12" version="1">MHLSLLPLCPIAEELYKNHKTFHDGDSGLDLFIIEDQVIKAGETAYIKLGFKAAAHSDDGKPVSYLLFARSSISKSPIRLCNSVGLIDAGYRGELLAPVDNIKDFDFQVKKGERYFQLVSFNGEKITFSIVDELDKTTRGEGGFGSTDKLDSVKGLPQKIAKIDTENAENLIENVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXT4</accession>
    <name>Q5CXT4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ubiqutin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_5020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628646.1">
        <property type="nucleotide sequence ID" value="XM_628644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXT4"/>
    <dbReference type="STRING" id="353152.Q5CXT4"/>
    <dbReference type="GeneID" id="3372236"/>
    <dbReference type="KEGG" id="cpv:cgd7_5020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5020"/>
    <dbReference type="InParanoid" id="Q5CXT4"/>
    <dbReference type="OMA" id="MDNPITQ"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17039">
        <property type="entry name" value="Ubl_ubiquitin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000001">
        <property type="entry name" value="Ubiquilin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="9"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="494"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="82"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="360"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="536" mass="58090" checksum="AEDE69C46F851FAF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXU1</accession>
    <name>Q5CXU1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Pantothenate kinase 4, rnaseH fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_4950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628639.1">
        <property type="nucleotide sequence ID" value="XM_628637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXU1"/>
    <dbReference type="STRING" id="353152.Q5CXU1"/>
    <dbReference type="GeneID" id="3372231"/>
    <dbReference type="KEGG" id="cpv:cgd7_4950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4950"/>
    <dbReference type="InParanoid" id="Q5CXU1"/>
    <dbReference type="OMA" id="FKNPDIC"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd24086">
        <property type="entry name" value="ASKHA_NBD_PanK-II_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="363" mass="41340" checksum="F0BF42EA5854EDE4" modified="2005-04-12" version="1">MKSLFEKYSLDIIGVGVLNQVPNDSHYGLDIGGTLIKLVYTLSLENDELFEYELENMRKNFYDIEALRTNRKYVIFCLIAPVNKEIELQIGDIFGFLKERGLYKPNSVPMTGGGSVKFKTILESKYKIKVVRFDEMRSIVNGCFELFGNLSTGNLQQPHFYSILKGETFLVRMDSQTRIFPSLVISVGSGVSIIRVENQNQFERVSGTRFGGGTVFGISKLLGVENYGDLLKLYSSYERKNGQNLGESTHSSGCFFKEFVKESSITSLSLPQYLGEAEQKEKFVHNIVNMMYSDLSYLICLISSNYKYENIVFCGNYVSNHHKIIIKSIKKYSYMLNDKVNVFFHYLDGFFGAIGAYLSHKCN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY49</accession>
    <name>Q5CY49_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TPR repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_3680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628531.1">
        <property type="nucleotide sequence ID" value="XM_628529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY49"/>
    <dbReference type="STRING" id="353152.Q5CY49"/>
    <dbReference type="GeneID" id="3372117"/>
    <dbReference type="KEGG" id="cpv:cgd7_3680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3680"/>
    <dbReference type="InParanoid" id="Q5CY49"/>
    <dbReference type="OMA" id="TCTRIMK"/>
    <dbReference type="OrthoDB" id="329563at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12895">
        <property type="entry name" value="ANAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="485"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="519"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="553"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="791" mass="91647" checksum="A15212235C14086C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY71</accession>
    <name>Q5CY71_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Major facilitator (MFS) superfamily transporter containing 12 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_3450</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628509.1">
        <property type="nucleotide sequence ID" value="XM_628507.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY71"/>
    <dbReference type="STRING" id="353152.Q5CY71"/>
    <dbReference type="GeneID" id="3372060"/>
    <dbReference type="KEGG" id="cpv:cgd7_3450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3450"/>
    <dbReference type="InParanoid" id="Q5CY71"/>
    <dbReference type="OMA" id="VAGWMSY"/>
    <dbReference type="OrthoDB" id="331466at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF9">
        <property type="entry name" value="PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="42"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="111"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="135"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="199"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="466"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="503"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="533"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="566"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="46"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="635" mass="70227" checksum="BFF2873D14A5C3BF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY88</accession>
    <name>Q5CY88_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">JAB domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628492.1">
        <property type="nucleotide sequence ID" value="XM_628490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY88"/>
    <dbReference type="FunCoup" id="Q5CY88">
        <property type="interactions" value="284"/>
    </dbReference>
    <dbReference type="GeneID" id="3372046"/>
    <dbReference type="KEGG" id="cpv:cgd7_3280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3280"/>
    <dbReference type="InParanoid" id="Q5CY88"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08060">
        <property type="entry name" value="MPN_UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005366">
        <property type="entry name" value="EMC8/9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12941:SF10">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 8_9 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03665">
        <property type="entry name" value="UPF0172"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="190" mass="21646" checksum="4575ED8136AE7DE0" modified="2005-04-12" version="1">MKIEFNQTSYEKILSHSIKYPQSFIDGVLIGYSSGQTNLIITDSFPLSHGPKLPLMVTLGIQYAQGYCDILNRLDKSPKLEIIGFYSGLPDEKCLNSGGSKTYLDLISEKLLANNKNSILVTFSGQKVLFKESINVYLLRNKQLLLHTFIEDPLRLETKRLKDLEYYNLCDFEDHLCNIQPKLVNNPLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY96</accession>
    <name>Q5CY96_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein with 3 CCCH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_3190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628484.1">
        <property type="nucleotide sequence ID" value="XM_628482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY96"/>
    <dbReference type="GeneID" id="3372297"/>
    <dbReference type="KEGG" id="cpv:cgd7_3190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3190"/>
    <dbReference type="InParanoid" id="Q5CY96"/>
    <dbReference type="OMA" id="MEGNISI"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045868">
        <property type="entry name" value="Znf_C3H13/40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38160">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38160:SF1">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="37"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="311" mass="35292" checksum="73D2B8C8728AF8F8" modified="2005-04-12" version="1">MESLRDNFSTNIGPSCFASNASLFQRRNSSELVRRQLYKTKMCAFYNVGKCTRGNLCAFAHSVQELRPLPDLRFTRLCELTKRGDVCRDVNCTFAHSINDLRTTEIPPTPLSEFNIMRSNENTALIRKLGSTSESKTKFRTGESIKDPFLSKSEGEDIFVSSADTTPQSLRPQLRNTEYEIPCQWRKIDNIISQNVGSIRSGIFSYLNETETSQIDNWVYNEEFASRFSPDISTHSETSCKFVNNSDFQEPPNYFSSKCLLARGIPDWDFISNDDKISTLQCDILNIIGGDGNHHTEDICSIEKGALHMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYB9</accession>
    <name>Q5CYB9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Coatomer subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_2940</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10 11">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Cytoplasmic vesicle</location>
            <location evidence="10 11">COPI-coated vesicle membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10 11">Golgi apparatus membrane</location>
            <topology evidence="10 11">Peripheral membrane protein</topology>
            <orientation evidence="10 11">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628461.1">
        <property type="nucleotide sequence ID" value="XM_628459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYB9"/>
    <dbReference type="FunCoup" id="Q5CYB9">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYB9"/>
    <dbReference type="GeneID" id="3372278"/>
    <dbReference type="KEGG" id="cpv:cgd7_2940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2940"/>
    <dbReference type="InParanoid" id="Q5CYB9"/>
    <dbReference type="OMA" id="VQFRTHP"/>
    <dbReference type="OrthoDB" id="10266042at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051645">
        <property type="term" value="P:Golgi localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd14830">
        <property type="entry name" value="Delta_COP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000003">
        <property type="entry name" value="Coatomer subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027059">
        <property type="entry name" value="Coatomer_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10121:SF0">
        <property type="entry name" value="COATOMER SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="5 10" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="12">
        <location>
            <begin position="310"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU364018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU366052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK90305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="535" mass="60711" checksum="28BE77964ABD208C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYF6</accession>
    <name>Q5CYF6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628424.1">
        <property type="nucleotide sequence ID" value="XM_628422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYF6"/>
    <dbReference type="GeneID" id="3371920"/>
    <dbReference type="KEGG" id="cpv:cgd7_2520"/>
    <dbReference type="InParanoid" id="Q5CYF6"/>
    <dbReference type="OMA" id="HYIDLMF"/>
    <dbReference type="OrthoDB" id="343002at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="205" mass="24017" checksum="C55308975D503752" modified="2005-04-12" version="1">MNRVKHRICCDILERELPLLFYKNALSFESRPTEKSSPVQLCYPDLSMTLGFHPYNFNIYQLNTDAEDEDVFDRPSIIISTECKEFNNIREDVYRWGVLYLICTVLLLVYILKIIMESQLNINHFIGIKINKTAFHIICFLLSFSPLLAVTEGCPFFMIVYKALFPSMLTIIFVYFLNEVWDILFVFLFSVARLSISAIQYKMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYI8</accession>
    <name>Q5CYI8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_2180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628392.1">
        <property type="nucleotide sequence ID" value="XM_628390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYI8"/>
    <dbReference type="GeneID" id="3371894"/>
    <dbReference type="KEGG" id="cpv:cgd7_2180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2180"/>
    <dbReference type="InParanoid" id="Q5CYI8"/>
    <dbReference type="OMA" id="WINISAN"/>
    <dbReference type="OrthoDB" id="341215at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="285" mass="33127" checksum="A122A3297C6EFD07" modified="2005-04-12" version="1">MYFNTLKHTTIQNLKSSEWIFFFFKHLLSENPCTFRDLYFYKHSEESTIECDASLIYLTMQEPFVKLSMLENNYIDISDAKITKEIIILQKLLSTSIITEHEFKDCLLEICVEIETNPNLKQNVQELVDKNIISQIFLLDGIFDTILSELKVGVSYLEQFINLQIEDWSLKSENKNLVKFSISKLGNIKGWVSVLRISTPKDESNIDFFSKVNISLIDLLRIMLKFRRHLICPNHIIVEEIKATWKLVSEEISMASIIQAISTICYGNVQLQNSFSQNQDGKFSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYJ1</accession>
    <name>Q5CYJ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628389.1">
        <property type="nucleotide sequence ID" value="XM_628387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYJ1"/>
    <dbReference type="GeneID" id="3371892"/>
    <dbReference type="KEGG" id="cpv:cgd7_2130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2130"/>
    <dbReference type="InParanoid" id="Q5CYJ1"/>
    <dbReference type="OMA" id="WPLNIEE"/>
    <dbReference type="OrthoDB" id="341295at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="258"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="303" mass="34898" checksum="3379D9AC7BCCAE09" modified="2005-04-12" version="1">MGFSGDKIESSCNIRSQRRLRTDTAEAVFGNFWEAPKNSNFHSRGVKKNKQNYEHEIAENSTQKSDSDSLDKKFNITNLDTQERLSFYESQGAEPYLSKYPTITSILTETQPKRWMIMFSRAQSSSSRDSKDGKNNKKNSKINSSGLTNEDLPFNKMQFIWSSELDEHKRVKLNNKNSPSSQSLLSDPNDLSPIVINFPHPIQLQNISIPYEVLDPRSVPCGSFIWWDRRVWEYNFVYMARRLSTNDEKSRKKLNIENPVTPKKQIRALGESNGQSSKRSRPKVDANPKLNQKSKSPKNVIKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYX6</accession>
    <name>Q5CYX6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_640</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the DEAD box helicase family. DEAH subfamily. PRP16 sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628254.1">
        <property type="nucleotide sequence ID" value="XM_628252.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYX6"/>
    <dbReference type="FunCoup" id="Q5CYX6">
        <property type="interactions" value="414"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYX6"/>
    <dbReference type="GeneID" id="3372008"/>
    <dbReference type="KEGG" id="cpv:cgd7_640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_640"/>
    <dbReference type="InParanoid" id="Q5CYX6"/>
    <dbReference type="OMA" id="VDVMFHR"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF91">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE PRP16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="329"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="525"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="10">
        <location>
            <begin position="8"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="44"/>
            <end position="56"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK90547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1042" mass="118748" checksum="52655204CEF40BED" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPL8</accession>
    <name>A3FPL8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GTP-binding nuclear protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Monomer. Found in a nuclear export complex with RanGTP, exportin and pre-miRNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the small GTPase superfamily. Ran family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388364.1">
        <property type="nucleotide sequence ID" value="XM_001388327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPL8"/>
    <dbReference type="FunCoup" id="A3FPL8">
        <property type="interactions" value="525"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPL8"/>
    <dbReference type="GeneID" id="3371863"/>
    <dbReference type="KEGG" id="cpv:cgd7_220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_220"/>
    <dbReference type="InParanoid" id="A3FPL8"/>
    <dbReference type="OMA" id="FNAWDTA"/>
    <dbReference type="OrthoDB" id="48625at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000054">
        <property type="term" value="P:ribosomal subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00877">
        <property type="entry name" value="Ran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000369">
        <property type="entry name" value="GTP-binding nuclear protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002041">
        <property type="entry name" value="Ran_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071:SF0">
        <property type="entry name" value="GTP-BINDING NUCLEAR PROTEIN RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24071">
        <property type="entry name" value="RAN GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00627">
        <property type="entry name" value="GTPRANTC4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51418">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5 9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00065175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="212" mass="24110" checksum="4D4722A7F239AB84" modified="2007-04-03" version="1">MAAQAPEFKLALVGDGGVGKTTLVKRHLTGEFEKKYIPTIGVEVHPLKFNTDFGPLIFNVWDTAGQEKFGGLRDGYYIKGQCAIIMFDVTSRITYKNVPNWHRDIVRVCENIPIVLVGNKVDVKDRQVKARQIQYHRKRNLQYYDISARSNYNFEKPFLWLARRLTNQPALQLVGQHAKAPEVNIDPTLVAQAERELSEAANAPIEDDDEDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPL9</accession>
    <name>A3FPL9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 2 homolog</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd7_280</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388365.1">
        <property type="nucleotide sequence ID" value="XM_001388328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPL9"/>
    <dbReference type="STRING" id="353152.A3FPL9"/>
    <dbReference type="BindingDB" id="A3FPL9"/>
    <dbReference type="ChEMBL" id="CHEMBL4295532"/>
    <dbReference type="GeneID" id="3371864"/>
    <dbReference type="KEGG" id="cpv:cgd7_280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_280"/>
    <dbReference type="InParanoid" id="A3FPL9"/>
    <dbReference type="OMA" id="LEGVRYC"/>
    <dbReference type="OrthoDB" id="335911at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000611">
        <property type="entry name" value="CMGC family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="18" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="14"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="353"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="371"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="44"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAZ51558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="392" mass="44926" checksum="62EEC72706607B1E" modified="2007-04-03" version="1">MQQTTVIKSKTTSYVVLQDLGSGTYGRVVKAYDQNNPTHLVAIKLFHLEEHEDEGVPATSIRELDILRTLNHPNIVDLYEVHYSRPTDGSPLLMGVFELCANDLKKHCKVHTQQLRDRYPDLKNPIAEHTAWAKELMFQLLNGMAYCHSHNIMHRDLKPQNVLMGMDGVLKIGDFGLARACRLPIPEYTHDVLTMWYRAPEILLGIDKYSPSVDVWSVGCIMAELLRGGHALLPGECEIDMVWRIFRYFGTPTEESWPEIGKLKYFDKNFPVWTCNVQENLKNLCKLADASAIDLLSKLLVCNPNKRISCKNALLHPWFDDIDRSKYVMWDSRVVLPSPRNLHSRFNEMINDENVQQNNRASRRSLTKGVSSDKRRRDSDKRNAKPTVGAVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPM6</accession>
    <name>A3FPM6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_1050</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNAPC3/SRD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388372.1">
        <property type="nucleotide sequence ID" value="XM_001388335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPM6"/>
    <dbReference type="STRING" id="353152.A3FPM6"/>
    <dbReference type="GeneID" id="3371871"/>
    <dbReference type="KEGG" id="cpv:cgd7_1050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1050"/>
    <dbReference type="InParanoid" id="A3FPM6"/>
    <dbReference type="OMA" id="VEFMISK"/>
    <dbReference type="OrthoDB" id="46583at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003681">
        <property type="term" value="F:bent DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001046">
        <property type="term" value="F:core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022042">
        <property type="entry name" value="snRNA-activating_su3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13421:SF16">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12251">
        <property type="entry name" value="SNAPC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="179"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="189"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="439" mass="51484" checksum="EF4C398EC1419FB0" modified="2007-04-03" version="1">MEENILGYYRKAYIRTEFPMNVYSTNDFSKKATEILSSLLELTYSSTLNFQLQNEINEGINSIQVGTYYEEIEKMLHNELDLEKDMHMKYVDSLTLQRLKNLSPSRVTRNRLSRIPGKIVRIPTGLVSLKEIEQNRRREIFWNSYFLTRLCRNTRLRRQFVSVNSIVLPHFLSRKRYSLSNTNSNHHHSNIERERKGESKNQKEREEESKSEKERERKEKKESKSEIVKDGTIIVTVSFYHQIRGMKISEFDILETQTLSELSNSFICHDSKQEEELLGFHPTGDCFEINGDLYLNGTDDIKSNFINTLSGFTMKSNPQIFDMKNTQISHLNIPINSHSTYIHSGDCEHRVTFTNIRLFNSKYDSPYKDSYPIQIYSHSRTLTFCEICGINQVTKVIFNSLNLPRNPSQLCDSCTFIFLYDKNTKQSIEKCIIRSINNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPP7</accession>
    <name>A3FPP7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">S1/P1nuclease, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_3110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the nuclease type I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388393.1">
        <property type="nucleotide sequence ID" value="XM_001388356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPP7"/>
    <dbReference type="STRING" id="353152.A3FPP7"/>
    <dbReference type="GeneID" id="3371835"/>
    <dbReference type="KEGG" id="cpv:cgd7_3110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3110"/>
    <dbReference type="InParanoid" id="A3FPP7"/>
    <dbReference type="OMA" id="HQPLRIA"/>
    <dbReference type="OrthoDB" id="441446at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11010">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.575.10">
        <property type="entry name" value="P1 Nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008947">
        <property type="entry name" value="PLipase_C/P1_nuclease_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003154">
        <property type="entry name" value="S1/P1nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33146:SF26">
        <property type="entry name" value="ENDONUCLEASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02265">
        <property type="entry name" value="S1-P1_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48537">
        <property type="entry name" value="Phospholipase C/P1 nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002652616" evidence="9">
        <location>
            <begin position="23"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="363"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009547"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="416" mass="47592" checksum="D4014708D60144BD" modified="2007-04-03" version="1">MLVFLSIKCTIKVLLLLGQVLAFDAEGHSAIGMTTISGLQNNFSQKLRRLMNGKDIVDISGWGERVSKKHPSTLPFHFQGQSKGDYFKNGELGNDFKEKFILKSDSNCKHTGHCLVPMIKHLYYRLIGDNSKFKINYPEGIQLTDSDSIKFLINLIGDLHQPMHFGFIEDGLGREIKGMMSINGTNERLSLFEIWESGIARKLKTEKPQFWFGGWTHILAIRDIFDKELLLWKERGIEMINDWAKENFEIVTNEIYFHPISKQPIIDNFNVDVTLEFAWLEIFRSRILIAGARLSIILNDILKLREGKEKPFRVTNSLLLSSDEDISHNISDPIIGINVNRKQTLEINVFGKKIGISVWIRNLIINLIIILICLAVLAYISIFRLRDNYSILNNAQLPVSEVKTKSVQMKQTSAID</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPQ9</accession>
    <name>A3FPQ9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cgd7_4360 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388405.1">
        <property type="nucleotide sequence ID" value="XM_001388368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPQ9"/>
    <dbReference type="GeneID" id="3371807"/>
    <dbReference type="KEGG" id="cpv:cgd7_4360"/>
    <dbReference type="InParanoid" id="A3FPQ9"/>
    <dbReference type="OrthoDB" id="423313at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="145" mass="16538" checksum="217F421AFF469F82" modified="2007-04-03" version="1">MDPLESDGTVLLPQIFVDGVCIGNDVSLQDLEEDNDFDWIINRRACGACLSDKEEDMEVCPNCNQVFKTIVPPELVYSGGIQQMYRGNNTAAQEGVLFEHPTNFVKNNNSNLNLNRNERYGDYQDEEEYDNIAEEEYSELDIKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPU2</accession>
    <name>A3FPU2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Conserved hypothetical multi-pass transmembrane protein, possible ion transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd6_2140</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388321.1">
        <property type="nucleotide sequence ID" value="XM_001388284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPU2"/>
    <dbReference type="STRING" id="353152.A3FPU2"/>
    <dbReference type="GeneID" id="3375946"/>
    <dbReference type="KEGG" id="cpv:cgd6_2140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2140"/>
    <dbReference type="InParanoid" id="A3FPU2"/>
    <dbReference type="OMA" id="CKRSINS"/>
    <dbReference type="OrthoDB" id="433309at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005267">
        <property type="term" value="F:potassium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013099">
        <property type="entry name" value="K_chnl_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047871">
        <property type="entry name" value="K_chnl_Slo-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027">
        <property type="entry name" value="CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10027:SF10">
        <property type="entry name" value="SLOWPOKE 2, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07885">
        <property type="entry name" value="Ion_trans_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81324">
        <property type="entry name" value="Voltage-gated potassium channels"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0407">Ion channel</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0630">Potassium</keyword>
    <keyword evidence="5" id="KW-0631">Potassium channel</keyword>
    <keyword evidence="3" id="KW-0633">Potassium transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="171"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Potassium channel" evidence="12">
        <location>
            <begin position="121"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAZ51515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1017" mass="117028" checksum="478CB3E5B5DF1CC1" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPW2</accession>
    <name>A3FPW2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ras-related protein Rab-1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Small GTP-binding protein rab1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_3830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Protein transport. Probably involved in vesicular traffic from ER to Golgi.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388341.1">
        <property type="nucleotide sequence ID" value="XM_001388304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPW2"/>
    <dbReference type="STRING" id="353152.A3FPW2"/>
    <dbReference type="GeneID" id="3375966"/>
    <dbReference type="KEGG" id="cpv:cgd6_3830"/>
    <dbReference type="InParanoid" id="A3FPW2"/>
    <dbReference type="OMA" id="CLIVRFS"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001018">
        <property type="entry name" value="Rab family GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00053444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00067099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00081865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="208" mass="23339" checksum="D707D5D3DF546CA0" modified="2007-04-03" version="1" fragment="single">FIFSDFLFKLVLIGDSGVGKSCLLLRFAQDDSFTDSYITTIGVDFRFRTIKIDDKIIKLQIWDTAGQERFRTITSAYYRGADGVVLVYDTTSTSSFDHIDEWVTEVNRYTTDSTKILIGNKCDLTSQKMVDFATGQKKAQELQVDFMESSAKNSTNVEECFVNIARKLLEKKLKNGETSSKPINSQNIYLNQHGDGGLISGVLSSCCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPW3</accession>
    <name>A3FPW3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SNF2 helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_3860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388342.1">
        <property type="nucleotide sequence ID" value="XM_001388305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPW3"/>
    <dbReference type="STRING" id="353152.A3FPW3"/>
    <dbReference type="GeneID" id="3375967"/>
    <dbReference type="KEGG" id="cpv:cgd6_3860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3860"/>
    <dbReference type="InParanoid" id="A3FPW3"/>
    <dbReference type="OMA" id="VHDYQFF"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036306">
        <property type="entry name" value="ISWI_HAND-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015195">
        <property type="entry name" value="SLIDE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09111">
        <property type="entry name" value="SLIDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101224">
        <property type="entry name" value="HAND domain of the nucleosome remodeling ATPase ISWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="197"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="500"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="125"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1102" mass="127709" checksum="0997FBF17E127274" modified="2007-04-03" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPW6</accession>
    <name>A3FPW6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphdiesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_4020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388345.1">
        <property type="nucleotide sequence ID" value="XM_001388308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPW6"/>
    <dbReference type="SMR" id="A3FPW6"/>
    <dbReference type="STRING" id="353152.A3FPW6"/>
    <dbReference type="GeneID" id="3375969"/>
    <dbReference type="KEGG" id="cpv:cgd6_4020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4020"/>
    <dbReference type="InParanoid" id="A3FPW6"/>
    <dbReference type="OMA" id="WNINITT"/>
    <dbReference type="OrthoDB" id="189220at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004114">
        <property type="term" value="F:3',5'-cyclic-nucleotide phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1300.10">
        <property type="entry name" value="3'5'-cyclic nucleotide phosphodiesterase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002073">
        <property type="entry name" value="PDEase_catalytic_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036971">
        <property type="entry name" value="PDEase_catalytic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11347">
        <property type="entry name" value="CYCLIC NUCLEOTIDE PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00233">
        <property type="entry name" value="PDEase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109604">
        <property type="entry name" value="HD-domain/PDEase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51845">
        <property type="entry name" value="PDEASE_I_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="PDEase" evidence="4">
        <location>
            <begin position="850"/>
            <end position="1202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1206" mass="140762" checksum="2FABC085720E841D" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPX5</accession>
    <name>A3FPX5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5 6">Acylphosphatase</fullName>
            <ecNumber evidence="2 5 6">3.6.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_4900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4 5 6">
            <text>an acyl phosphate + H2O = a carboxylate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14965"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29067"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:59918"/>
            <dbReference type="EC" id="3.6.1.7"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the acylphosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.7" evidence="2 5 6"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388354.1">
        <property type="nucleotide sequence ID" value="XM_001388317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPX5"/>
    <dbReference type="FunCoup" id="A3FPX5">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="3375979"/>
    <dbReference type="KEGG" id="cpv:cgd6_4900"/>
    <dbReference type="InParanoid" id="A3FPX5"/>
    <dbReference type="OMA" id="WVRNTSH"/>
    <dbReference type="OrthoDB" id="7961613at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003998">
        <property type="term" value="F:acylphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.100:FF:000011">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020456">
        <property type="entry name" value="Acylphosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001792">
        <property type="entry name" value="Acylphosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036046">
        <property type="entry name" value="Acylphosphatase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017968">
        <property type="entry name" value="Acylphosphatase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029">
        <property type="entry name" value="ACYLPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10029:SF3">
        <property type="entry name" value="ACYLPHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00708">
        <property type="entry name" value="Acylphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00112">
        <property type="entry name" value="ACYLPHPHTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54975">
        <property type="entry name" value="Acylphosphatase/BLUF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00150">
        <property type="entry name" value="ACYLPHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00151">
        <property type="entry name" value="ACYLPHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51160">
        <property type="entry name" value="ACYLPHOSPHATASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acylphosphatase-like" evidence="8">
        <location>
            <begin position="32"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="47"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="65"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="123"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="123" mass="14123" checksum="89010FFC59C7A8D9" modified="2007-04-03" version="1" fragment="single">IIFNSKKKKKKNNNKNRLCSIVHSLDVLRMLKCEFEVFGKVQGVSFRKYTFLKANELNVFGWCKNTPSGTVIGELEGDEDSVIKMIDFLEREGSPGSTIEKCVVSNRRTVEEHAFNSFRIRCD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPY3</accession>
    <name>A3FPY3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388424.1">
        <property type="nucleotide sequence ID" value="XM_001388387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPY3"/>
    <dbReference type="STRING" id="353152.A3FPY3"/>
    <dbReference type="GeneID" id="3374643"/>
    <dbReference type="KEGG" id="cpv:cgd8_1660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1660"/>
    <dbReference type="InParanoid" id="A3FPY3"/>
    <dbReference type="OMA" id="YMENESI"/>
    <dbReference type="OrthoDB" id="68483at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14008">
        <property type="entry name" value="STKc_LKB1_CaMKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="81"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="404" mass="46880" checksum="2129CF887B75FE39" modified="2007-04-03" version="1">MMITKGGDYSEYSEIHTQDIEKSKDYDQECVELRKSVREYLEKESKINLYFSEKKSYLINKEFVDIQVQLNSQLCPKVKLWKRIEEPNSKEFSKLKNNPTQHLFAIKIYSKPQLIRRNIVYSSDRKIRTQMHRVINEIKILQFLAKTDPTYYYIAKLHKVLESFPSTLSSGKLYLIFDFFPIGPTMAPDTGARRARACPGFEKNLLVYTPSPALERTEVSIRRMAYCIGVALSRLHELGIVHRDVKPDNIMLTHTGDAFLNDFNSAEFLIQGKYVQGTEGTYAFFPPEHCNINNNSNKIVTERNESSEINEQEECSQSTLQLGCPADMWALGVTIWCWFYGTLPFQGNSILELFDNITKCKIEFPRQPTLSNECINAILHLLDPEPNSRWTARQFLESDWFSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ00</accession>
    <name>A3FQ00_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_4250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388441.1">
        <property type="nucleotide sequence ID" value="XM_001388404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ00"/>
    <dbReference type="STRING" id="353152.A3FQ00"/>
    <dbReference type="GeneID" id="3374355"/>
    <dbReference type="KEGG" id="cpv:cgd8_4250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4250"/>
    <dbReference type="InParanoid" id="A3FQ00"/>
    <dbReference type="OMA" id="CHVAVAD"/>
    <dbReference type="OrthoDB" id="5327538at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="240" mass="27478" checksum="FB26D2A5BAD26BCD" modified="2007-04-03" version="1">MFRVMDSQVSIISYLGLTLNIYITIFVSLIWALFVHGMKLWFEILFGVWILRRISPFSKILIERLYRLLGLESVVLENKDLRGTVCIVTGGATGIGKKVSEFFVKCGATVIIADIQENKGRVTAYKINTNNSSTGLARYMYIDLSDEKSIRSFVKRFTYDYDRLDILVNNAGIGSGSGYRKEESNDFEKYINKVFQVNYIGTFILTELLLPILKVSFEQGLLSQLSEKIYIYVYIITFII</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ20</accession>
    <name>A3FQ20_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Centrin, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_1270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the centrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388100.1">
        <property type="nucleotide sequence ID" value="XM_001388063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ20"/>
    <dbReference type="STRING" id="353152.A3FQ20"/>
    <dbReference type="GeneID" id="3374088"/>
    <dbReference type="KEGG" id="cpv:cgd3_1270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1270"/>
    <dbReference type="InParanoid" id="A3FQ20"/>
    <dbReference type="OMA" id="HPGLTQQ"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000077">
        <property type="entry name" value="Centrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF48">
        <property type="entry name" value="CENTRIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="53"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="125"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="161"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="196" mass="21963" checksum="52F6DFB49645988C" modified="2007-04-03" version="1">MKNIMRSRPSSSSSLGVNGISGLGGGSGSNLGGNGIGNSYMGSVSKRTELTEQQKMEIKEAFELFDGDSIGYIDIKEVKVAMRALGFDPKKEELKKILSNVELNNGMVSYNDFYDLVETKILQRDPKEEIIKAFKLFDDDETGKITFKNLKRVAKELGENISDEEIQEMIDEADRDGDGEINQEEFIRIMRKTNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQG3</accession>
    <name>A3FQG3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ARF GTPase activating protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388247.1">
        <property type="nucleotide sequence ID" value="XM_001388210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQG3"/>
    <dbReference type="STRING" id="353152.A3FQG3"/>
    <dbReference type="GeneID" id="3373034"/>
    <dbReference type="KEGG" id="cpv:cgd5_140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_140"/>
    <dbReference type="InParanoid" id="A3FQG3"/>
    <dbReference type="OMA" id="AWYESIN"/>
    <dbReference type="OrthoDB" id="6036at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044820">
        <property type="entry name" value="AGD14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46085">
        <property type="entry name" value="ARFGAP/RECO-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="2">
        <location>
            <begin position="8"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="192" mass="22511" checksum="F91BEB3F8BCEDE9D" modified="2007-04-03" version="1" fragment="single">MSLIFDETELIERLRSFQKSCIENRKCANCNEIGPNYVCINFGTFVCSVCSGIHREFNHKVKGISLSKWKFDEIRLICSLGNKKDFLTFLGNRDFNSLGPPPNSNNHLILKEFIRNKYINRIWINQSLYNLYYLNLSSIQDSLPKSQTNNSKNPYKTFQPNNITEYEHKNYDNSNLNAKKNFIDRNPFSFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQH1</accession>
    <name>A3FQH1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA synthetases class I catalytic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_610</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388255.1">
        <property type="nucleotide sequence ID" value="XM_001388218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQH1"/>
    <dbReference type="STRING" id="353152.A3FQH1"/>
    <dbReference type="GeneID" id="3373371"/>
    <dbReference type="KEGG" id="cpv:cgd5_610"/>
    <dbReference type="InParanoid" id="A3FQH1"/>
    <dbReference type="OMA" id="HKCWEDS"/>
    <dbReference type="OrthoDB" id="10249672at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004823">
        <property type="term" value="F:leucine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006429">
        <property type="term" value="P:leucyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.740.10">
        <property type="entry name" value="Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004493">
        <property type="entry name" value="Leu-tRNA-synth_Ia_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794:SF1">
        <property type="entry name" value="LEUCINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45794">
        <property type="entry name" value="LEUCYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="7">
        <location>
            <begin position="418"/>
            <end position="496"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="632" mass="72488" checksum="D0D6C45802606DDC" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQH7</accession>
    <name>A3FQH7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">WD-40 repeat protein family / small nuclear ribonucleoprotein Prp4p-related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_1130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388261.1">
        <property type="nucleotide sequence ID" value="XM_001388224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQH7"/>
    <dbReference type="STRING" id="353152.A3FQH7"/>
    <dbReference type="GeneID" id="3373365"/>
    <dbReference type="KEGG" id="cpv:cgd5_1130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1130"/>
    <dbReference type="InParanoid" id="A3FQH7"/>
    <dbReference type="OMA" id="ARIDIAM"/>
    <dbReference type="OrthoDB" id="540662at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030621">
        <property type="term" value="F:U4 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846:SF0">
        <property type="entry name" value="PRE-MRNA PROCESSING FACTOR 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="4">
        <location>
            <begin position="12"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="212"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="254"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="296"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="341"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="401"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="439" mass="50589" checksum="7988B848B25C00B2" modified="2007-04-03" version="1">MNYIFINSAVSTNDEIVKLQLRELGEPICYFGEDQYRRRERLSNLIERQKNSTEVIKDSVKPLAKETFFSEGTDELMSFRKKILALSIKKSYYRLKYTREFSEKILTKEKDDFLTRFTLNIRQNICEMCDTRYILGCSISPLEDKIATYGLSGDLKVWDSKKLIQDFFLKSHKHSITDVNWIVTDEGNSKLFSCDLNANIFLWNNSQVENKYIGHEDQVNKIVIHPFSKHLFSASSDETWRIWDIETLNQVQVQEGHSRPIFGLDVHPDGALVVSGDSGGAFRIWDIRTGRSILSQLAHSKKIITSQFSPNCDATFITSSQDNYIKIWDLRRFDKPLLSSLLGHSKQISKVQYEPKKGRYIASASLDESIKIWSTSKLKNESTIDFNSDFSRITYSCIKRVDTNSHKITGMDISSNGQRIITVGLDRTIRVWSSESENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQN4</accession>
    <name>A3FQN4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Peptidase S26 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd4_620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the peptidase S26 family. IMP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAZ51240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388052.1">
        <property type="nucleotide sequence ID" value="XM_001388015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQN4"/>
    <dbReference type="STRING" id="353152.A3FQN4"/>
    <dbReference type="GeneID" id="3372628"/>
    <dbReference type="KEGG" id="cpv:cgd4_620"/>
    <dbReference type="InParanoid" id="A3FQN4"/>
    <dbReference type="OMA" id="LCKGPSM"/>
    <dbReference type="OrthoDB" id="308440at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042720">
        <property type="term" value="C:mitochondrial inner membrane peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006627">
        <property type="term" value="P:protein processing involved in protein targeting to mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06530">
        <property type="entry name" value="S26_SPase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.109.10">
        <property type="entry name" value="Umud Fragment, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036286">
        <property type="entry name" value="LexA/Signal_pep-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052064">
        <property type="entry name" value="Mito_IMP1_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000223">
        <property type="entry name" value="Pept_S26A_signal_pept_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019758">
        <property type="entry name" value="Pept_S26A_signal_pept_1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019533">
        <property type="entry name" value="Peptidase_S26"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383:SF16">
        <property type="entry name" value="MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12383">
        <property type="entry name" value="PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10502">
        <property type="entry name" value="Peptidase_S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00727">
        <property type="entry name" value="LEADERPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51306">
        <property type="entry name" value="LexA/Signal peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00761">
        <property type="entry name" value="SPASE_I_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S26" evidence="8">
        <location>
            <begin position="112"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="37"/>
        </location>
    </feature>
    <feature type="active site" evidence="7">
        <location>
            <position position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600223-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF10502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="164" mass="19322" checksum="2A6C4C299D17CC2B" modified="2007-04-03" version="1">MPNKFIFRTSLKYAKILLGIHLIQKYGFSICITDGPSMIPTIGPKRELLLYEKLSISLSRIFKLNGNFPVNRNDIIIANSVENPEILVCKRVIGKNCNFIDFIHKRHSCFQMKIPPNYFWIQGDNFNNSRDSRNYGPIHESLIIGRVIYKVSNFYYYYYYYITN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQN7</accession>
    <name>A3FQN7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAZ51243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388055.1">
        <property type="nucleotide sequence ID" value="XM_001388018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQN7"/>
    <dbReference type="FunCoup" id="A3FQN7">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQN7"/>
    <dbReference type="GeneID" id="3372625"/>
    <dbReference type="KEGG" id="cpv:cgd4_890"/>
    <dbReference type="InParanoid" id="A3FQN7"/>
    <dbReference type="OMA" id="EWALNIH"/>
    <dbReference type="OrthoDB" id="274726at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009846">
        <property type="entry name" value="SF3b5/RDS3-10"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20978:SF0">
        <property type="entry name" value="SPLICING FACTOR 3B SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07189">
        <property type="entry name" value="SF3b10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAZ51243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="85" mass="9839" checksum="CF3299C2DC5A6512" modified="2007-04-03" version="1">MDGENRSTIYFQLEQLHSKYQGTGHINTKRSSEWGDNILRDTASSNIMHQSRISYFAIAENTSKARISFRMLESMIPASLKKREQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQQ0</accession>
    <name>A3FQQ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CDP-diacylglycerol--inositol 3-phosphatidyltransferase isoform 1 phosphatidylinositol synthase PtdIns synthase PI synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAZ51224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388419.1">
        <property type="nucleotide sequence ID" value="XM_001388382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQQ0"/>
    <dbReference type="FunCoup" id="A3FQQ0">
        <property type="interactions" value="208"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQQ0"/>
    <dbReference type="GeneID" id="3372482"/>
    <dbReference type="KEGG" id="cpv:cgd8_560"/>
    <dbReference type="InParanoid" id="A3FQQ0"/>
    <dbReference type="OMA" id="SHGCNEL"/>
    <dbReference type="OrthoDB" id="10251079at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="9"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="154" mass="17762" checksum="6B0377F2241F3E56" modified="2007-04-03" version="1">MITDRCSTVIIIILAITLNKSYTFLMIIFLIGDISGHWLYMISSISSGGSSHKSIKEEMWPILKLYYSKKPLLFTLHACNEALWLILYGQGCIYDKATNLKQLNQIDKKFILVTSYSLYMILPLALIKNIINFVHLFYGCNIILETDVKERMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPG2</accession>
    <name>Q5CPG2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">rRNA biogenesis protein RRP36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Associates with 90S and pre-40S pre-ribosomal particles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the RRP36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625331.1">
        <property type="nucleotide sequence ID" value="XM_625331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPG2"/>
    <dbReference type="STRING" id="353152.Q5CPG2"/>
    <dbReference type="GeneID" id="3372312"/>
    <dbReference type="KEGG" id="cpv:cgd3_170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_170"/>
    <dbReference type="InParanoid" id="Q5CPG2"/>
    <dbReference type="OMA" id="MIPERRY"/>
    <dbReference type="OrthoDB" id="448446at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009292">
        <property type="entry name" value="RRP36"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21738:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING PROTEIN 36 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06102">
        <property type="entry name" value="RRP36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="56"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="75"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU368027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="266" mass="31830" checksum="7C8F0A0C343C6167" modified="2005-04-12" version="1">MDFEDIPFEEIIRKEKIAESFEKRKSAESEKKNANGSYKSCKEFEKNDEIDQRLKKYGRITSKNSPMEVSSRRQILPEKLENERNYIRNKHDSSKKGNDPRFNDSCGKLNTDLFHKSYDFLDDMRQREFNQIKNTLDLYKIMTKSKELGTWNKVKKSSKFKNSDVNHLTQDQIDNLKLKYQKLVSEKDHRKNLYLKQQTISQHRKQEQTKIESGKKPFFLKQKDINLSIQHDKYKNLNKKQISMLEQKINRKNVSKFKPPTSLRKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPK1</accession>
    <name>Q5CPK1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">histone deacetylase</fullName>
            <ecNumber evidence="2">3.5.1.98</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_80</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histone deacetylase family. HD type 1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.5.1.98" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625348.1">
        <property type="nucleotide sequence ID" value="XM_625348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPK1"/>
    <dbReference type="SMR" id="Q5CPK1"/>
    <dbReference type="FunCoup" id="Q5CPK1">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPK1"/>
    <dbReference type="GeneID" id="3375652"/>
    <dbReference type="KEGG" id="cpv:cgd6_80"/>
    <dbReference type="InParanoid" id="Q5CPK1"/>
    <dbReference type="OMA" id="GWLRAFH"/>
    <dbReference type="OrthoDB" id="1918432at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0141221">
        <property type="term" value="F:histone deacetylase activity, hydrolytic mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09991">
        <property type="entry name" value="HDAC_classI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.800.20:FF:000010">
        <property type="entry name" value="Histone deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003084">
        <property type="entry name" value="HDAC_I/II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000286">
        <property type="entry name" value="HDACs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF44">
        <property type="entry name" value="HISTONE DEACETYLASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037913">
        <property type="entry name" value="His_deacetylse_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01270">
        <property type="entry name" value="HDASUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01271">
        <property type="entry name" value="HISDACETLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Histone deacetylase" evidence="9">
        <location>
            <begin position="38"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="409"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="111"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="161"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="276"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="315"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR037913-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="460" mass="52200" checksum="145845DA7A4A3051" modified="2005-04-12" version="1" fragment="single">ILLVSHLNNIVVISLKMAKRVSYFYDGDIGSYYYGPGHPMKPQRIRMAHNLILSYDLYKHMEIYKPHKSPQSELVYFHEEDYINFLSSINPDNSKDFGLQLKRFNLGETTDCPVFDGLFEFQQICAGGSIDGAYKLNNEQSDICINWSGGLHHAKRSEASGFCYINDIVLGILELLKYHARVMYIDIDVHHGDGVEEAFYLSHRVLTVSFHKFGEFFPGTGDITDIGVAQGKYYSVNVPLNDGIDDDSFLSLFKPIISKCIEVYRPGAIVLQCGADSVRGDRLGRFNLSIKGHAECVEFCKKFNIPLLILGGGGYTIRNVARTWAYETATILDRTDLISDNIPLNDYYDYFAPDFKLHIPPLNLPNMNSPEHLEKIKAKVIDNLRYLEHAPGVEFAYVPSDFFDREASNLQKQEDEEREEELSSWQGGGRAAGSTESQGNHNEKPKSSRKLQKEHASEFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPL3</accession>
    <name>Q5CPL3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide, serine stretches, possible low mw mucin glycoprotein, locus of 6 genes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625408.1">
        <property type="nucleotide sequence ID" value="XM_625408.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPL3"/>
    <dbReference type="STRING" id="353152.Q5CPL3"/>
    <dbReference type="GeneID" id="3372380"/>
    <dbReference type="KEGG" id="cpv:cgd2_410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_410"/>
    <dbReference type="InParanoid" id="Q5CPL3"/>
    <dbReference type="OMA" id="SSAACHY"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254236" evidence="2">
        <location>
            <begin position="22"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="81"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="81"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="261" mass="28172" checksum="F6B74CA4D9627D54" modified="2005-04-12" version="1">MQLRNCLILIIFVFSLSFLSFEHRNERDIVVKDRVSFLKLRNGISFGPNLCRRLCCCRGNGNDLSTQDVVVFAVDNPAFNSNDESSESSSSNSMESVPNPDPSNIPVPSSGPVVSSTSQYSGYSSTSEPIPIPVRPGSNQGQSTPSFPSPCSPSASASKLGFLGMRSPSVSSCVRHSSSSSSLSSSSTSSSSYSSSSSSSEDEDRETSTNKESGKRGHRGRKTGKKSRSRSKSRSRSKFKSRSKSRSRSPSPVFKFDEELT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPP1</accession>
    <name>Q5CPP1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625380.1">
        <property type="nucleotide sequence ID" value="XM_625380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPP1"/>
    <dbReference type="GeneID" id="3372371"/>
    <dbReference type="KEGG" id="cpv:cgd2_100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_100"/>
    <dbReference type="InParanoid" id="Q5CPP1"/>
    <dbReference type="OrthoDB" id="341944at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="240" mass="27716" checksum="B5BB54CAC908F2BE" modified="2005-04-12" version="1">MYNKTFIHEDVYEIHNDVSSLYHDNHQHSSRTVLKQINHSKQVRFNSSPPEVFEYEALDPENFLYDNNYHEINFNVKGQGISGNDSYDFFEIEDRSGVYENETSTNGKNVLTLPIPNRRELFELENYPSDLNQNNLQTLGSLRVEDILSIDGKFIQKTTLSDTNYDTNSSNADPGFSEHVDKWINLKDIKLEIDKISINKEPSNSFNDIIVSKNHPTNNDQLNNPDFVDLQSTTESLSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPR0</accession>
    <name>Q5CPR0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_4390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625454.1">
        <property type="nucleotide sequence ID" value="XM_625454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPR0"/>
    <dbReference type="GeneID" id="3372442"/>
    <dbReference type="KEGG" id="cpv:cgd4_4390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4390"/>
    <dbReference type="InParanoid" id="Q5CPR0"/>
    <dbReference type="OrthoDB" id="342811at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="194" mass="22159" checksum="B0C24DF0BB7FE48E" modified="2005-04-12" version="1">MFGNDAGQTWDTLWETAVKVRYSNNEQILCKKESNENYRDFFIRNQEDAEKKFKTHILKRSKSIGVSKVKRATNTELNKANRRTLSLHSGSYSSKNNTSSKRSINILESTPIFNTHNPLFKPKNVKITSFNNRSNKSSNPILREYFEQKSKDNSIHRLYSSANSRISSVSSSSAKAATSSVKFNGKPEVTYIFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPR1</accession>
    <name>Q5CPR1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_4380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625453.1">
        <property type="nucleotide sequence ID" value="XM_625453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPR1"/>
    <dbReference type="GeneID" id="3372444"/>
    <dbReference type="KEGG" id="cpv:cgd4_4380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4380"/>
    <dbReference type="InParanoid" id="Q5CPR1"/>
    <dbReference type="OMA" id="QFQTING"/>
    <dbReference type="OrthoDB" id="342679at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254804" evidence="1">
        <location>
            <begin position="23"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="224" mass="26270" checksum="71A92AB529E9BA90" modified="2005-04-12" version="1">MKISIRIISFLSSILLLNGIESLKFNEEYIRKNTKSNIKLDNIQESPLLECTDALNSWSYFAKMTVKKLLDDEFKKDEYIFFLETLIPQISTIDESFNQCRTELLKYNISTKNETSQFKLEMKSKGEKEMVFNTKKSVKEVLKRIEELNKRNGDINDAKKLILNFDSRNICTECNIFSSQMALISVIKRLRLIYNSYITELESNIDPNILEEIEKSENKTMKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPT0</accession>
    <name>Q5CPT0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_4180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625434.1">
        <property type="nucleotide sequence ID" value="XM_625434.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372402"/>
    <dbReference type="KEGG" id="cpv:cgd4_4180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4180"/>
    <dbReference type="InParanoid" id="Q5CPT0"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="123" mass="14799" checksum="5884B4617A40F360" modified="2005-04-12" version="1">MIFIKMIMKNFQFQKIKAISRQRIYEMITEIQNREDLYXFNEDRKIELLGKYYIILRYLKNNLISISLGKVHIDNYIKNSLGMNIKEFQTSKNSNINLMEDFNSNINNNNNNNNNNNNIQEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPV0</accession>
    <name>Q5CPV0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Archeo-eukaryotic exosomal RNAse</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_3930</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625414.1">
        <property type="nucleotide sequence ID" value="XM_625414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPV0"/>
    <dbReference type="FunCoup" id="Q5CPV0">
        <property type="interactions" value="346"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPV0"/>
    <dbReference type="GeneID" id="3372428"/>
    <dbReference type="KEGG" id="cpv:cgd4_3930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3930"/>
    <dbReference type="InParanoid" id="Q5CPV0"/>
    <dbReference type="OMA" id="ECRINTH"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF0">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="32"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="3">
        <location>
            <begin position="107"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="351" mass="40312" checksum="96D5DB82ACD6E420" modified="2005-04-12" version="1">MNNLIVWIFLIHKNLTYFFLFQINFGKSGLKISIFAFITFKAKFINLFFFFFFFLTEKKGIGYLFFFFKNYKFFFLRKFFFFFQIKKKMNEIVNKHGIRQDGRKLTEIRRIKCIINEGNQRGIEDGNVYFEQGQNKLIVSIVGPVPISGNINYTNNNSGVQINCNFRVSPFSSQDRRKRGKNDRFCIESGLIISRTFSSVICDQYSKSQIIINIIILEGDGSVRSAAINATSIALAISGISMKDLIVSATCGLYGKQVLYDLTQSEMESLKGTLLMAIHSTDNDIDTDTENVGNGNSDISPVTIDLNTKLKPEMIEFLMNETFSACKQFSVIIRDFLKNYTCNKYQSIYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPW4</accession>
    <name>Q5CPW4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CpTSP12 extracellular protein with 1 TSP1 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625515.1">
        <property type="nucleotide sequence ID" value="XM_625515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPW4"/>
    <dbReference type="GeneID" id="3372459"/>
    <dbReference type="KEGG" id="cpv:cgd8_540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_540"/>
    <dbReference type="InParanoid" id="Q5CPW4"/>
    <dbReference type="OMA" id="RYSECES"/>
    <dbReference type="OrthoDB" id="446173at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254107" evidence="2">
        <location>
            <begin position="20"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="597"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="825" mass="94001" checksum="DDD1A957C227B7DF" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ26</accession>
    <name>Q5CQ26_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_4380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625600.1">
        <property type="nucleotide sequence ID" value="XM_625600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ26"/>
    <dbReference type="GeneID" id="3372584"/>
    <dbReference type="KEGG" id="cpv:cgd5_4380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4380"/>
    <dbReference type="InParanoid" id="Q5CQ26"/>
    <dbReference type="OrthoDB" id="342092at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="161" mass="19197" checksum="DC5F4B106A0724F2" modified="2005-04-12" version="1">MFNMQFEGTLNYPKPNHSVKEMVKLFDIKSNDFNNTISTINSDSNHFEQELKTTKKKSNYQNNTKKIKKVLDPLQSSLYVIDQEHFEIFDPVYPSMTEIFQQRIKKKKYPKTSSKTNNINNKTLSNFSQNKYNNNHIINNYFNYLWQVGDEFSEIHCFPLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ40</accession>
    <name>Q5CQ40_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Calponin-homology (CH) domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_4240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625586.1">
        <property type="nucleotide sequence ID" value="XM_625586.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372570"/>
    <dbReference type="KEGG" id="cpv:cgd5_4240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4240"/>
    <dbReference type="InParanoid" id="Q5CQ40"/>
    <dbReference type="OMA" id="LANIEIC"/>
    <dbReference type="OrthoDB" id="341666at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00014">
        <property type="entry name" value="CH_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.10">
        <property type="entry name" value="Calponin-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001715">
        <property type="entry name" value="CH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036872">
        <property type="entry name" value="CH_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47576">
        <property type="entry name" value="Calponin-homology domain, CH-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50021">
        <property type="entry name" value="CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calponin-homology (CH)" evidence="2">
        <location>
            <begin position="2"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="584"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="594"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="794" mass="93343" checksum="8CF2A61311489526" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ47</accession>
    <name>Q5CQ47_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_4160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625579.1">
        <property type="nucleotide sequence ID" value="XM_625579.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372531"/>
    <dbReference type="KEGG" id="cpv:cgd5_4160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4160"/>
    <dbReference type="InParanoid" id="Q5CQ47"/>
    <dbReference type="OrthoDB" id="343309at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="320" mass="35573" checksum="2FB67AA5A495BF3D" modified="2005-04-12" version="1">MINFKMFKKSSDYKIQVLIQLVLICFFILLGQIKGDKTNTKFTGWISEGLISSVNNETALSECKMLLPYGVDQKEIIKVAFYCKDDEIISYIGVNNQVVDHSSANYIDEIQNLKIGCSNGYSFISFGGSKLSHYNNTSPGYPIVASSITAGFTPGGSSRIPSLVLLEGYFSQIHSFSIRRRVSSLESTNSRKWSGEKFIGGCFALLPISQPGNLIYSIAGIGFIPKGNAXSTLTYSSKGIYLKNMIYTVGKVFPECQTLEGPENNHKKKNPVVYYSIICPNGHFNKFRTYKKYSFGTANLASIEVSLRGKKIINIMNCEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ76</accession>
    <name>Q5CQ76_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_3860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625550.1">
        <property type="nucleotide sequence ID" value="XM_625550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ76"/>
    <dbReference type="GeneID" id="3372594"/>
    <dbReference type="KEGG" id="cpv:cgd5_3860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3860"/>
    <dbReference type="InParanoid" id="Q5CQ76"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="124" mass="14415" checksum="E6213CB2BF14F4EC" modified="2005-04-12" version="1">MQGNGERYTLSESLESDIISMNIYITGARVTFDIYSYSIFEIINNEWIFMEEKYIQNPLVYSFNTMGMQIKLELSDKFEVEIINIAIHGIIHNVINSLPKFISCNINDISCECPDSKFIKYNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ87</accession>
    <name>Q5CQ87_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_3740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625539.1">
        <property type="nucleotide sequence ID" value="XM_625539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ87"/>
    <dbReference type="FunCoup" id="Q5CQ87">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ87"/>
    <dbReference type="GeneID" id="3372587"/>
    <dbReference type="KEGG" id="cpv:cgd5_3740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3740"/>
    <dbReference type="InParanoid" id="Q5CQ87"/>
    <dbReference type="OMA" id="DLGQWVG"/>
    <dbReference type="OrthoDB" id="10249311at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000530">
        <property type="entry name" value="Ribosomal_eS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047860">
        <property type="entry name" value="Ribosomal_eS12_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11843">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00972">
        <property type="entry name" value="RIBSOMALS12E"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01189">
        <property type="entry name" value="RIBOSOMAL_S12E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="5">
        <location>
            <begin position="26"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="143" mass="15835" checksum="53CD0D5C6BCC6D69" modified="2005-04-12" version="1">MSDVEIDQEGTQVQVEQEVVNDLTTAIRYVLKNSFVRGGLLRGLNEVVLALDSKKAQVCFLAESCEEDCYKQLVEALCRERGIPLIMVPDSKELGEMAGLCKVDREGNPRKVVGAASVAIVDYGVESEAYHYLQKHIAENCRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQI6</accession>
    <name>Q5CQI6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_570</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="5">Protein modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625662.1">
        <property type="nucleotide sequence ID" value="XM_625662.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQI6"/>
    <dbReference type="FunCoup" id="Q5CQI6">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQI6"/>
    <dbReference type="GeneID" id="3372655"/>
    <dbReference type="KEGG" id="cpv:cgd4_570"/>
    <dbReference type="InParanoid" id="Q5CQI6"/>
    <dbReference type="OMA" id="VHFTTRI"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd23792">
        <property type="entry name" value="UBCc_UBE2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000001">
        <property type="entry name" value="Ubiquitin-conjugating enzyme 28, E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24068">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254409" evidence="8">
        <location>
            <begin position="28"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="domain" description="UBC core" evidence="9">
        <location>
            <begin position="15"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="6">
        <location>
            <position position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00043952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="161" mass="18298" checksum="B086AF4B8166365F" modified="2005-04-12" version="1" fragment="single">TVFPIFELTNHLFHIFLFLIIQELSDLNRDPPTNCSAGPIGDDMFHWQATIMGPDDSSYAGGVFFLNIQFPSDYPFKPPKVNFTTKIYHCNINSNGAICLDILKEQWSPALTISKVLLSISSLLTDANPDDPLVPEIAHLYKTDRSKYEQTAREWTQKYAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQM4</accession>
    <name>Q5CQM4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pre-mRNA splicing protein Prp31p--like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625624.1">
        <property type="nucleotide sequence ID" value="XM_625624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQM4"/>
    <dbReference type="FunCoup" id="Q5CQM4">
        <property type="interactions" value="440"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQM4"/>
    <dbReference type="GeneID" id="3372665"/>
    <dbReference type="KEGG" id="cpv:cgd4_150"/>
    <dbReference type="InParanoid" id="Q5CQM4"/>
    <dbReference type="OMA" id="EMRRSAN"/>
    <dbReference type="OrthoDB" id="4771285at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027105">
        <property type="entry name" value="Prp31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019175">
        <property type="entry name" value="Prp31_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13904:SF0">
        <property type="entry name" value="U4_U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09785">
        <property type="entry name" value="Prp31_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253746" evidence="5">
        <location>
            <begin position="21"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Nop" evidence="6">
        <location>
            <begin position="223"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="346"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="425"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="4">
        <location>
            <begin position="347"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="426"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="463" mass="51915" checksum="F31743EE063DF67B" modified="2005-04-12" version="1" fragment="single">FHVLNPTLLINLCIFLLVYLQSYQSSLQELLLKDLEDLDYSASSNINNKGQISEDGKYSDDEIISKIGNLNDRLFGKMIDSSTNVMNSNYQLKDFGNEIYGTFQEIIDIVGIIDSKVSEKYECVKALYKDHFGELASIIINKIDYLEVVKRIITHENFEDVKLNDILPNSTIMTITISSSTSKRNIPTLEKKESILKCIDFVNQINESKSKILEFLQFQIEAITPNLSALIGPEIAANLLCVSGGLKNLAEMPSQNIMVLGSLKNNKKNGHFSTGPVRLELLQSIISQSDIVRNIQDKYKKKAIRLVSLKCGLCARIDFSSTDKSPDHGVNYRNYILNILEKAQEPPQKPMKKPLPIPKDFPKSRRGGKRIRKIKEKFKQTKIKKEMNRMKFGEEEEEYTVDGKTIGLGLLSAGEGGRRIRGLQVGSLKSSSSSSKIETLSGSDSKLGSSTSISFTPYQGMIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQT3</accession>
    <name>Q5CQT3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_3430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625919.1">
        <property type="nucleotide sequence ID" value="XM_625919.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQT3"/>
    <dbReference type="GeneID" id="3372869"/>
    <dbReference type="KEGG" id="cpv:cgd4_3430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3430"/>
    <dbReference type="InParanoid" id="Q5CQT3"/>
    <dbReference type="OMA" id="YYLSFSE"/>
    <dbReference type="OrthoDB" id="341452at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253752" evidence="3">
        <location>
            <begin position="24"/>
            <end position="2128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="703"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1408"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1454"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1522"/>
            <end position="1595"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="822"/>
            <end position="978"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1343"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="705"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1522"/>
            <end position="1565"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2128" mass="245830" checksum="2024BBE685613A2F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQU2</accession>
    <name>Q5CQU2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 10">Phosphoacetylglucosamine mutase</fullName>
            <shortName evidence="10">PAGM</shortName>
            <ecNumber evidence="4 10">5.4.2.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9 10">Acetylglucosamine phosphomutase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 10">N-acetylglucosamine-phosphate mutase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">cgd4_3310</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23804"/>
            <dbReference type="ChEBI" id="CHEBI:57513"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="5.4.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10 13">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; N-acetyl-alpha-D-glucosamine 1-phosphate from alpha-D-glucosamine 6-phosphate (route I): step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.3" evidence="4 10"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625910.1">
        <property type="nucleotide sequence ID" value="XM_625910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQU2"/>
    <dbReference type="FunCoup" id="Q5CQU2">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQU2"/>
    <dbReference type="GeneID" id="3372780"/>
    <dbReference type="KEGG" id="cpv:cgd4_3310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3310"/>
    <dbReference type="InParanoid" id="Q5CQU2"/>
    <dbReference type="OMA" id="EHEKYLI"/>
    <dbReference type="OrthoDB" id="1928at2759"/>
    <dbReference type="UniPathway" id="UPA00113">
        <property type="reaction ID" value="UER00530"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004610">
        <property type="term" value="F:phosphoacetylglucosamine mutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03086">
        <property type="entry name" value="PGM3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005843">
        <property type="entry name" value="A-D-PHexomutase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049022">
        <property type="entry name" value="AMG1_III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016657">
        <property type="entry name" value="PAGM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45955:SF1">
        <property type="entry name" value="PHOSPHOACETYLGLUCOSAMINE MUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21404">
        <property type="entry name" value="AMG1_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00408">
        <property type="entry name" value="PGM_PMM_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016408">
        <property type="entry name" value="PAGM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="6 10 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="15">
        <location>
            <begin position="65"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphoacetylglucosamine mutase AMG1" evidence="16">
        <location>
            <begin position="382"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase C-terminal" evidence="14">
        <location>
            <begin position="600"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="active site" description="Phosphoserine intermediate" evidence="11">
        <location>
            <position position="72"/>
        </location>
    </feature>
    <feature type="binding site" description="via phosphate group" evidence="13">
        <location>
            <position position="72"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="356"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="358"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="360"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="473"/>
            <end position="475"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="605"/>
            <end position="609"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="614"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000558"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00032065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR016408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR016408-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF21404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAK87792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="643" mass="73609" checksum="DB1C95D108686351" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQV2</accession>
    <name>Q5CQV2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Small ribosomal subunit protein eS1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_3160</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="5">Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the eukaryotic ribosomal protein eS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625900.1">
        <property type="nucleotide sequence ID" value="XM_625900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQV2"/>
    <dbReference type="FunCoup" id="Q5CQV2">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQV2"/>
    <dbReference type="GeneID" id="3372787"/>
    <dbReference type="KEGG" id="cpv:cgd4_3160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3160"/>
    <dbReference type="InParanoid" id="Q5CQV2"/>
    <dbReference type="OMA" id="TRFKGHE"/>
    <dbReference type="OrthoDB" id="9834376at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03122">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001593">
        <property type="entry name" value="Ribosomal_eS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018281">
        <property type="entry name" value="Ribosomal_eS1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027500">
        <property type="entry name" value="Ribosomal_eS1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11830">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01015">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01397">
        <property type="entry name" value="Ribosomal_S3Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01191">
        <property type="entry name" value="RIBOSOMAL_S3AE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="initiator methionine" description="Removed" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="262" mass="29789" checksum="838689CAACD17ED2" modified="2005-04-12" version="1">MAIGKNKRISKGRKGGRKKIIDPLSRKEFYDLRAPSTFKVRNFGTTIASKNQGTKLAVDALRHRVYEVSLADLNNDEDQAFRKIKLQCEDIQGRTCLTEFHGMDMTRDKLCSLIRKYQTLIEAHCNVKTSDGYVLRLFCIAFTRRMADQVKSTCYAQTSQIRQIRKKMVEIITAEAEGTTLRDLVKKFIPESIGKEIEKACRHIFPLQHVFIRKVKVLSKPSFDVSRLMESHVGADGVEEKGTKVVSESNQATNLLTAEMKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR80</accession>
    <name>Q5CR80_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ring domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_1780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625772.1">
        <property type="nucleotide sequence ID" value="XM_625772.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR80"/>
    <dbReference type="GeneID" id="3372901"/>
    <dbReference type="KEGG" id="cpv:cgd4_1780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1780"/>
    <dbReference type="InParanoid" id="Q5CR80"/>
    <dbReference type="OMA" id="HAYLFPI"/>
    <dbReference type="OrthoDB" id="344146at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="427"/>
            <end position="466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="477" mass="55129" checksum="08BAF35BCF526CA9" modified="2005-04-12" version="1">MISFLQSQLQDEDEMNINYNQNNSETQAEDINVEGDGLDLGNITDLGADLNDLMNDNEENTFGVSLYEDLIDINSIDVERNNSNLQKTIENEVTLKSKIETSLLVYKVNCERSDTIIIYEEKNVKFGLSNDLIGTGTLILEKIEDSDVFALSWEGKLLECFSSNKQSIQDVSKYSFLLQYIIDINIKIIQDDEFFIFIKSDFQLENETIFLQFSFNSEEKANFWYNNLTKYKRLIIKKTNVEENDNNTKQTQVKRSREYSNDCQINDQKHKSLSISNSQPPKISIPFYRDNKHSKKSSNIPNTLSYYQSENLFPLVKHEDKVHIENQIKNLIYTNISITNDLDNNSTDVLSSFDIESNKSIIKQKCSFIKFIVNSIQSNIVENKTSSLSISTFPKSIQSSSSCDNTLNFQATKENYAQNSQPQIFTCPICYESFDYNDIITLQPCGHQLCFYCEHRLVDSKCPWDRSKYTIKTQEKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR85</accession>
    <name>Q5CR85_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CDC48 like AAA ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_1730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625767.1">
        <property type="nucleotide sequence ID" value="XM_625767.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR85"/>
    <dbReference type="FunCoup" id="Q5CR85">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR85"/>
    <dbReference type="GeneID" id="3372765"/>
    <dbReference type="KEGG" id="cpv:cgd4_1730"/>
    <dbReference type="InParanoid" id="Q5CR85"/>
    <dbReference type="OMA" id="AICTESH"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19511">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000661">
        <property type="entry name" value="calmodulin-interacting protein 111 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF27">
        <property type="entry name" value="ATPASE FAMILY GENE 2 PROTEIN HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="310"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="598"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="891" mass="101459" checksum="44806C63C4E0B176" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRG4</accession>
    <name>Q5CRG4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626222.1">
        <property type="nucleotide sequence ID" value="XM_626222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRG4"/>
    <dbReference type="STRING" id="353152.Q5CRG4"/>
    <dbReference type="GeneID" id="3373237"/>
    <dbReference type="KEGG" id="cpv:cgd5_2860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2860"/>
    <dbReference type="InParanoid" id="Q5CRG4"/>
    <dbReference type="OMA" id="WKELNIN"/>
    <dbReference type="OrthoDB" id="341032at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615:SF80">
        <property type="entry name" value="GRIP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45615">
        <property type="entry name" value="MYOSIN HEAVY CHAIN, NON-MUSCLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="323"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="325"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="831"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="889"/>
            <end position="907"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="924" mass="107164" checksum="B346FE02F05D790E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRS0</accession>
    <name>Q5CRS0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626116.1">
        <property type="nucleotide sequence ID" value="XM_626116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRS0"/>
    <dbReference type="GeneID" id="3373009"/>
    <dbReference type="KEGG" id="cpv:cgd5_1720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1720"/>
    <dbReference type="InParanoid" id="Q5CRS0"/>
    <dbReference type="OrthoDB" id="340883at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="111" mass="12518" checksum="6625269010677A8A" modified="2005-04-12" version="1">MNNGMIVGVNMIESEQIRDSEYVFKEVKVIDMNTISDVDPATSATSEIETQKTTKTEPSFLRKYWWLIAIGFITYSVLTTDQSLTEHTEINSANGQIHEGKSSRKANKKSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRT2</accession>
    <name>Q5CRT2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_1570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Golgi apparatus membrane</location>
            <topology evidence="6">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626104.1">
        <property type="nucleotide sequence ID" value="XM_626104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRT2"/>
    <dbReference type="FunCoup" id="Q5CRT2">
        <property type="interactions" value="117"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRT2"/>
    <dbReference type="GeneID" id="3373019"/>
    <dbReference type="KEGG" id="cpv:cgd5_1570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1570"/>
    <dbReference type="InParanoid" id="Q5CRT2"/>
    <dbReference type="OMA" id="VMAMFGW"/>
    <dbReference type="OrthoDB" id="411251at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006977">
        <property type="entry name" value="Yip1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF1">
        <property type="entry name" value="PROTEIN YIPF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04893">
        <property type="entry name" value="Yip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="69"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="98"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="domain" description="Yip1" evidence="7">
        <location>
            <begin position="61"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="202" mass="23232" checksum="B7E6C31222F3A258" modified="2005-04-12" version="1">MSEIDRDIFVVSGDIYNGEESGGTLNEPIMKTVKRDIFLIYNKLHYFITAGKNEFDREYNLKMLYNWDLWGPCIILLVLSSCLYIKAPVENKDKIFSVLHFFSIYGTVAIALNARILGINCSFFAILSIVGYCIFPFTVISLISLIIPYFFVKLIFTILSITHIYKVMQLSMNEIAPEEKKVLILYPISLFFFSVAFLVLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS69</accession>
    <name>Q5CS69_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_20</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625967.1">
        <property type="nucleotide sequence ID" value="XM_625967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS69"/>
    <dbReference type="GeneID" id="3373341"/>
    <dbReference type="KEGG" id="cpv:cgd5_20"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_20"/>
    <dbReference type="InParanoid" id="Q5CS69"/>
    <dbReference type="OrthoDB" id="343779at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254468" evidence="2">
        <location>
            <begin position="20"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="138"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="696"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="696"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="736"/>
            <end position="754"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="760" mass="84814" checksum="A3E4A8BC54A4A8D8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS79</accession>
    <name>Q5CS79_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628188.1">
        <property type="nucleotide sequence ID" value="XM_628188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS79"/>
    <dbReference type="GeneID" id="3371510"/>
    <dbReference type="KEGG" id="cpv:cgd1_3770"/>
    <dbReference type="InParanoid" id="Q5CS79"/>
    <dbReference type="OrthoDB" id="341442at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="100" mass="11137" checksum="E88E70B2D9EC0D0F" modified="2005-04-12" version="1">MYLGLLPNGTESEFSRYIGTGVVILAIQCIILAFGIFVFISLLYYLLSNGDECRSESILNITLTSINLLHSTITTFTSVKLLLKLFTSIATQYKTYDKIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSB6</accession>
    <name>Q5CSB6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CS domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_3370</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628151.1">
        <property type="nucleotide sequence ID" value="XM_628151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSB6"/>
    <dbReference type="STRING" id="353152.Q5CSB6"/>
    <dbReference type="GeneID" id="3371586"/>
    <dbReference type="KEGG" id="cpv:cgd1_3370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3370"/>
    <dbReference type="InParanoid" id="Q5CSB6"/>
    <dbReference type="OMA" id="ITRTRYF"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="8"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="211" mass="24670" checksum="DF81C1F1E88E06F7" modified="2005-04-12" version="1">MSELDLGKCGDGYKWTQTEEEIYCEIKIYELMQKFGINMDLNKEARLIKNSLKIVIDMKSIKIFLKGICVFTKELSSNIDSETATWYLEECKDNESNNKGLILVILLEKKKKCWWDSCFLGESKLDLSQVQGRKNFRDCDERTKSEIIKLINNNNNNNNNNNNNNNNFDIHQVLKESWNKENSPFQGIEYDPKLVQKLMIGPNINQNIEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSE6</accession>
    <name>Q5CSE6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Cation diffusion facilitator like membrane protein transporter, 6x transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd1_3050</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628121.1">
        <property type="nucleotide sequence ID" value="XM_628121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSE6"/>
    <dbReference type="FunCoup" id="Q5CSE6">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSE6"/>
    <dbReference type="GeneID" id="3371709"/>
    <dbReference type="KEGG" id="cpv:cgd1_3050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3050"/>
    <dbReference type="InParanoid" id="Q5CSE6"/>
    <dbReference type="OMA" id="RTWGWAR"/>
    <dbReference type="OrthoDB" id="9944568at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1510.10">
        <property type="entry name" value="Cation efflux protein transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002524">
        <property type="entry name" value="Cation_efflux"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027470">
        <property type="entry name" value="Cation_efflux_CTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058533">
        <property type="entry name" value="Cation_efflux_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027469">
        <property type="entry name" value="Cation_efflux_TMD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050681">
        <property type="entry name" value="CDF/SLC30A"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01297">
        <property type="entry name" value="CDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562">
        <property type="entry name" value="CATION EFFLUX PROTEIN/ ZINC TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11562:SF17">
        <property type="entry name" value="RE54080P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01545">
        <property type="entry name" value="Cation_efflux"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16916">
        <property type="entry name" value="ZT_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161111">
        <property type="entry name" value="Cation efflux protein transmembrane domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0864">Zinc transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="30"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="56"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="131"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="285"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein transmembrane" evidence="10">
        <location>
            <begin position="30"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Cation efflux protein cytoplasmic" evidence="11">
        <location>
            <begin position="350"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="459" mass="51493" checksum="8C0319841D57F038" modified="2005-04-12" version="1">MMKDSGLEKPLLNGNGFKIFASTESVQKRLIYAIFFCLVFTLIEVVVGILSNSLALISDASHLISDICSYFISLLGIHLSKRKATNTMSFGYNRAEILGALLSILLIWFMTIMLVYEAIQRMLYPVNVDGFSMFITAIFGTLSNLFISFVLSVHNHGIGSIGVDCSQHNHSHEHMHEHDCKQAQTHFQDDSLYCKDQQLAENQEQIGGINTTLLEYHHRSQMRTKDLDHELNNYTNLMNSPVIRRVNSGLKECSGRQNDYSHLHSSNHYTSKHSSEQESLALKSAYIHVLGDILQNIGVMIAGLLILYNPAWTIADPLCTILFSFFVLATTIKILKDSANVLMEGTPIGIDCESIQNDFLKLSSVLEVHDLHVWSVSVGVPALSCHIVVASEDNARFTLRYATDLCQKKYGIFHTTIQIDYSPNKATCETIHHQKCLVGSNNQNKSEIHQIIHPVDYSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSG6</accession>
    <name>Q5CSG6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628101.1">
        <property type="nucleotide sequence ID" value="XM_628101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSG6"/>
    <dbReference type="GeneID" id="3371726"/>
    <dbReference type="KEGG" id="cpv:cgd1_2780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2780"/>
    <dbReference type="InParanoid" id="Q5CSG6"/>
    <dbReference type="OMA" id="DIDIWIQ"/>
    <dbReference type="OrthoDB" id="343406at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="288" mass="33187" checksum="A31314631482FE19" modified="2005-04-12" version="1">MNYNDYGCFKPFILSTYKSYFNISLGKALQIWSIICIIFNILIYQITFKNPNGLPFLVYTADTTTFYYYYFTMLSSSILALLTSIFSTRKLAISCLSLTLINLIANIAMLTNMNYIFLDKSSFGNHCIFESEFFRDWKKPLLQQCSESYSKICISNEKFYSDHLIRNCGILILEDDLSCGNFQKQLISNGIIDKFVNICISPSKYKYQAYLTIFVTYLHYLFILITTPIGFSILRVVYSIYCIVSVGGTGWEYLSAEELLLSPQAGLLNENPIIPFRYSLNGKNFLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSS6</accession>
    <name>Q5CSS6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted secreted protein, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_1510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627991.1">
        <property type="nucleotide sequence ID" value="XM_627991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSS6"/>
    <dbReference type="GeneID" id="3371615"/>
    <dbReference type="KEGG" id="cpv:cgd1_1510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1510"/>
    <dbReference type="InParanoid" id="Q5CSS6"/>
    <dbReference type="OMA" id="CEAGFIH"/>
    <dbReference type="OrthoDB" id="342522at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254341" evidence="2">
        <location>
            <begin position="25"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="180"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="236"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="277" mass="31194" checksum="FC0E052B12822306" modified="2005-04-12" version="1">MKLSFSVVLTLLIYTIGKPHGCEAGLLDTIAKAVGTYFKVFYPEVTTPRKDYSPDFELQDQLVVQSQEIMKGLVHIKNNITQIEDNWAGIKEFAELRRNPKNIFAENSLGIVDNLSDVISKMSLSSAFKNMEAPIVFLEPPSVAIKQEEQAGTPCITCVGRLSLSQSEFRIFKSEINRLKRIHAKTLQEANQELLEAEALAKETLQQRSKIIENIQKLSSVISLNEGVYGADNVELKFLQSDLAIAEQKHAALQQKQKALAKKIQELSSKKRSFWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSU1</accession>
    <name>Q5CSU1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VDP/USO1/YBL047C family vesicular transport factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627976.1">
        <property type="nucleotide sequence ID" value="XM_627976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSU1"/>
    <dbReference type="GeneID" id="3371589"/>
    <dbReference type="KEGG" id="cpv:cgd1_1340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1340"/>
    <dbReference type="InParanoid" id="Q5CSU1"/>
    <dbReference type="OMA" id="EWIECAC"/>
    <dbReference type="OrthoDB" id="198977at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="468"/>
            <end position="499"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1023" mass="117480" checksum="1E48D15A944A713E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSZ0</accession>
    <name>Q5CSZ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627927.1">
        <property type="nucleotide sequence ID" value="XM_627927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSZ0"/>
    <dbReference type="GeneID" id="3371533"/>
    <dbReference type="KEGG" id="cpv:cgd1_780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_780"/>
    <dbReference type="InParanoid" id="Q5CSZ0"/>
    <dbReference type="OMA" id="FFEDIFM"/>
    <dbReference type="OrthoDB" id="341021at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="215" mass="24910" checksum="2FCB86CD3BF14560" modified="2005-04-12" version="1">MSTQALEKITNKSEKEKIKKELYDEYEIFKVSNIYNEMDLTKAISNVISSIITLSGLEEQIQIYHRKNILMLIATVFGIFGAVVFKFPKDQWFILICVVGFFLSMFGTFLIDVKSPFSGFTNSYIVPKKLQEKGGFSLKNIWNYDKDACYITPKLNRASNDIEFLLQNQNHQVSKTIYVGKLFTLDGYINTDEIFEVISKLIVELYEKSNEKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT15</accession>
    <name>Q5CT15_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Possible emp24/gp25L/p24 family protein, transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_430</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627902.1">
        <property type="nucleotide sequence ID" value="XM_627902.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT15"/>
    <dbReference type="FunCoup" id="Q5CT15">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT15"/>
    <dbReference type="GeneID" id="3371375"/>
    <dbReference type="KEGG" id="cpv:cgd1_430"/>
    <dbReference type="InParanoid" id="Q5CT15"/>
    <dbReference type="OMA" id="IAMTNIN"/>
    <dbReference type="OrthoDB" id="759142at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="9">
        <location>
            <begin position="9"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="63"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="130" mass="14508" checksum="5BA4669137B6DB78" modified="2005-04-12" version="1" fragment="single">IPIEEKNPKAAFTTIKTGIHRFCFINTSQEDNWVSIALKWGPGAYDSGSIANKADFEPIDIAMTNINVALKEYQANIKQMKSLANSIQHATSNASNRIAAFSIFNIASIIVISVIQTLYIKKFFRSRKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT18</accession>
    <name>Q5CT18_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627899.1">
        <property type="nucleotide sequence ID" value="XM_627899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT18"/>
    <dbReference type="GeneID" id="3371377"/>
    <dbReference type="KEGG" id="cpv:cgd1_390"/>
    <dbReference type="InParanoid" id="Q5CT18"/>
    <dbReference type="OMA" id="QNIRMRT"/>
    <dbReference type="OrthoDB" id="338812at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="288" mass="33611" checksum="4C56CC2A1C1DB749" modified="2005-04-12" version="1" fragment="single">ESNNLNQSQKVFKFSIITMYTTKNNMNSGYADPRSLVLTLQELSTDYHKEIAEMNNILFQAKERYQLTLNENNEKIQRAQDKMSDENVQIQKEFEELRKMYEKNLPSLNEEKIMIQSQYYKEKSKFDCDFQTKVNEATNKLSEINVKLMTTSKEAVQEIEDLKAQLEREIAELNSEYRSNLSNIDVSYKKELNAVNQHIQDLTNYVNETTIKLNQRREQSSKDYHLSVERLTQDNNAAGEEYNATCISISQNIRMRTQNYENSASGIRNAIEGAINNQKRQVVHSPFA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT53</accession>
    <name>Q5CT53_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane associated protein with 11 transmembrane domains regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627864.1">
        <property type="nucleotide sequence ID" value="XM_627864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT53"/>
    <dbReference type="GeneID" id="3371444"/>
    <dbReference type="KEGG" id="cpv:cgd1_10"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_10"/>
    <dbReference type="InParanoid" id="Q5CT53"/>
    <dbReference type="OrthoDB" id="343307at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="337"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="437" mass="49714" checksum="1986B48F4EEBF9F8" modified="2005-04-12" version="1">MEENSVKFGNIDEEVSEKFVYNYFITGIIIGICKWIIIIAHFFCLNRNGASLLPIVEQSGFSFGTLLAHSLNVAIPLYMSLLGSQNYYLTILEKKSYKVRKNSFTYMVVPGIIYFFLSILLNFIGIPKHVSGSQLGMSPSKIFSIFKPGFLSFFLLAYLIMLFFSPFVAISIPSSGSIMEFKRFMSSTSNSDSNLEKGILIQKQAIAFNNSDMVKLSNIGAYSIIKCVVFSISVAYLLYFLHVSDSCIFKFFMFVSVIILTLSVGSFAFKEYLLETYVLLIIISIIWSFICLHGNSFFKSEIPDLICSTLSVYLTMYTAGHFFSCIGMEVVKSPSYYFLFIPVVALVYYNVNSYYVAISPILYPFYHCHFLFQKSLIISWLSIIPIISLCLNLCVYVKNKTVIWFISSLPDDVIIYILSLTPIFELFIGFYIHPVIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT70</accession>
    <name>Q5CT70_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cgd2_4200 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_4200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626599.1">
        <property type="nucleotide sequence ID" value="XM_626599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT70"/>
    <dbReference type="STRING" id="353152.Q5CT70"/>
    <dbReference type="GeneID" id="3373483"/>
    <dbReference type="KEGG" id="cpv:cgd2_4200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4200"/>
    <dbReference type="InParanoid" id="Q5CT70"/>
    <dbReference type="OMA" id="WPFNRWF"/>
    <dbReference type="OrthoDB" id="5348404at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23423">
        <property type="entry name" value="ORGANIC SOLUTE TRANSPORTER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="183"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="257"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="299"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="440" mass="50216" checksum="F8323D13C45485E2" modified="2005-04-12" version="1">MRWKWVVSSVATLLTLIISVVNIMHQYLNLCKPKLQLCICRILTMIPVYAIISYISYLFVDYASPLNIVRDCYEGYVMFSFLQLLIFYMGGDQVILSVLESNKIKAEIWPHHHFNHSLSMVGLASTAGSIESNEEEISVNIMDICPDYFCEKKDNLDEVSIDSGFQGDELANHRLKIARFYSFIKLGVLQFVILKPISALISLFLESIGLYGSGSFSFKRGYLYITVLNSISVSLSVYSLFLLYISISEQLAPIRPVLKFFCIKLIIFMSFWQSIILSVLSHFGIYPDEPNYTIKLHNWLLTIEMTVCAIIYGIAFTIKKDFKNYVESRQGYSQDDYNTDNLQDCEKTCHKDLFSGKDSGPMRNANFPPQASTDKPNLTLKISHLPSSISKNIKLYIYRFTCIVNPKDIIQDIISAFRFLKQINKSPNPEIKLGNSGATF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT84</accession>
    <name>Q5CT84_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_4030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626585.1">
        <property type="nucleotide sequence ID" value="XM_626585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT84"/>
    <dbReference type="GeneID" id="3373494"/>
    <dbReference type="KEGG" id="cpv:cgd2_4030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4030"/>
    <dbReference type="InParanoid" id="Q5CT84"/>
    <dbReference type="OMA" id="GTHENTH"/>
    <dbReference type="OrthoDB" id="340025at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="508"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="511"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="800" mass="92374" checksum="B9F98ABFBDE260D7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTD0</accession>
    <name>Q5CTD0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_3520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626539.1">
        <property type="nucleotide sequence ID" value="XM_626539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTD0"/>
    <dbReference type="GeneID" id="3373754"/>
    <dbReference type="KEGG" id="cpv:cgd2_3520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3520"/>
    <dbReference type="InParanoid" id="Q5CTD0"/>
    <dbReference type="OrthoDB" id="344241at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254224" evidence="2">
        <location>
            <begin position="22"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="77"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="87"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="315" mass="35602" checksum="741F3FFC921632C0" modified="2005-04-12" version="1">MFLRIALFILAFIGIFNSNSSFVKSPYKNYEFKYVQYFESFSFLKIKASAPTSGFCEKCGSRIYRVGCLCSSIGNHREGPNPSSSVEDSHSGRRDSNSRKDSKSRRDSKSRKDSKSRKDSKSRTTSRSRSGSRSRSGSKSRSGSRSRSQSPKDSKEQTTSTTTQHPLSKIKDPAVKLRLKSEKSSGIQNFKSVINDIKASIDDLLSKLIMECSLLFTPQFSALDVEELKEELMEMLTGFAGLKFLRQSHIPFLMAKEELNKLQGKNGLTIEELEEMLELCLTISYTIIDDLASIFDKKAKIRELKQEIQILMDLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTD2</accession>
    <name>Q5CTD2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626537.1">
        <property type="nucleotide sequence ID" value="XM_626537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTD2"/>
    <dbReference type="GeneID" id="3373626"/>
    <dbReference type="KEGG" id="cpv:cgd2_3500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3500"/>
    <dbReference type="InParanoid" id="Q5CTD2"/>
    <dbReference type="OMA" id="RIDISCW"/>
    <dbReference type="OrthoDB" id="343098at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="645"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="704" mass="82859" checksum="4ACAAFEAD00205B0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTF3</accession>
    <name>Q5CTF3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)</fullName>
            <ecNumber evidence="4">5.4.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_3260</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:23536"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="ChEBI" id="CHEBI:58601"/>
            <dbReference type="EC" id="5.4.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the phosphohexose mutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.2.2" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626516.1">
        <property type="nucleotide sequence ID" value="XM_626516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTF3"/>
    <dbReference type="SMR" id="Q5CTF3"/>
    <dbReference type="STRING" id="353152.Q5CTF3"/>
    <dbReference type="GeneID" id="3373554"/>
    <dbReference type="KEGG" id="cpv:cgd2_3260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3260"/>
    <dbReference type="InParanoid" id="Q5CTF3"/>
    <dbReference type="OMA" id="WRDPLFG"/>
    <dbReference type="OrthoDB" id="2291at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004614">
        <property type="term" value="F:phosphoglucomutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03085">
        <property type="entry name" value="PGM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.50:FF:000002">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.120.10:FF:000004">
        <property type="entry name" value="Phosphoglucomutase 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.120.10">
        <property type="entry name" value="Alpha-D-Glucose-1,6-Bisphosphate, subunit A, domain 3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.50">
        <property type="entry name" value="Alpha-D-phosphohexomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005844">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016055">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-I/II/III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005845">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005846">
        <property type="entry name" value="A-D-PHexomutase_a/b/a-III"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036900">
        <property type="entry name" value="A-D-PHexomutase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016066">
        <property type="entry name" value="A-D-PHexomutase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005841">
        <property type="entry name" value="Alpha-D-phosphohexomutase_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045244">
        <property type="entry name" value="PGM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005737">
        <property type="entry name" value="PRK07564.1-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573:SF2">
        <property type="entry name" value="PHOSPHOGLUCOMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22573">
        <property type="entry name" value="PHOSPHOHEXOMUTASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24947">
        <property type="entry name" value="PGM1_C_vert_fung"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02878">
        <property type="entry name" value="PGM_PMM_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02879">
        <property type="entry name" value="PGM_PMM_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02880">
        <property type="entry name" value="PGM_PMM_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00509">
        <property type="entry name" value="PGMPMM"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55957">
        <property type="entry name" value="Phosphoglucomutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53738">
        <property type="entry name" value="Phosphoglucomutase, first 3 domains"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00710">
        <property type="entry name" value="PGM_PMM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="10">
        <location>
            <begin position="12"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="11">
        <location>
            <begin position="189"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="Alpha-D-phosphohexomutase alpha/beta/alpha" evidence="12">
        <location>
            <begin position="310"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF02880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="568" mass="63249" checksum="30B5AE30A289DEBD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTN5</accession>
    <name>Q5CTN5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Glutamate 5-kinase, ProB like, PUA domain at the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_2300</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88758.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626434.1">
        <property type="nucleotide sequence ID" value="XM_626434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTN5"/>
    <dbReference type="STRING" id="353152.Q5CTN5"/>
    <dbReference type="GeneID" id="3373502"/>
    <dbReference type="KEGG" id="cpv:cgd2_2300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2300"/>
    <dbReference type="InParanoid" id="Q5CTN5"/>
    <dbReference type="OMA" id="NLAFPPH"/>
    <dbReference type="OrthoDB" id="409889at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004349">
        <property type="term" value="F:glutamate 5-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008652">
        <property type="term" value="P:amino acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04242">
        <property type="entry name" value="AAK_G5K_ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21157">
        <property type="entry name" value="PUA_G5K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1160.10:FF:000006">
        <property type="entry name" value="Glutamate 5-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1160.10">
        <property type="entry name" value="Acetylglutamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00456">
        <property type="entry name" value="ProB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036393">
        <property type="entry name" value="AceGlu_kinase-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001048">
        <property type="entry name" value="Asp/Glu/Uridylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041739">
        <property type="entry name" value="G5K_ProB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001057">
        <property type="entry name" value="Glu/AcGlu_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011529">
        <property type="entry name" value="Glu_5kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005715">
        <property type="entry name" value="Glu_5kinase/COase_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019797">
        <property type="entry name" value="Glutamate_5-kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01027">
        <property type="entry name" value="proB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43654:SF3">
        <property type="entry name" value="GLUTAMATE 5-KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00696">
        <property type="entry name" value="AA_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000729">
        <property type="entry name" value="GK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00474">
        <property type="entry name" value="GLU5KINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53633">
        <property type="entry name" value="Carbamate kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00902">
        <property type="entry name" value="GLUTAMATE_5_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0641">Proline biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PUA" evidence="8">
        <location>
            <begin position="393"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022650"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88758.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="487" mass="53379" checksum="7BE522B749FFA74A" modified="2005-04-12" version="1">MVKFGAYIIENNDNGPQLIRREKSGPLIVLKVGTSTLTNSRTGKLSVSNIGALVETVCDLMDKGCRVVLVSSGAVGAGLLHMNIREKPNKLHLKHAIAAIGQPLLMRVYEDFFSMRGAKVAQLLMTRSDFVNKDRFIDFKNTLLDLIHWNVVPIINENDSVTTIDLHFGDNDTLAAYCAIAISADWLILATDVDALFTKNPRLHRDAVPILKVNNIDSIIHMENDVSDENCGTNFGTGGMRTKIFAARIAAAAGISTFLVNGSHPNRLLQLVDSIDFKLNKAHNNNAISSYYSSTSEANDLENVSLCESLDMNSSSMESLADTKTCFEHSYSSIVGNFIEETPESTQVDNGIITCALEELYQGEYIGTIFARQALTQSMKNHKRWIMSLPISGKIFLDKGAIKSVTADSKSLFSVGIVNVKGKFETGDVVSIICDGDNDEREIARCVSNFNSELLKKIMGKKSCELNELLGLNSQGIVSDRANIIKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTP4</accession>
    <name>Q5CTP4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Ribosomal protein L37</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd2_2200</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the eukaryotic ribosomal protein eL37 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626425.1">
        <property type="nucleotide sequence ID" value="XM_626425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTP4"/>
    <dbReference type="FunCoup" id="Q5CTP4">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTP4"/>
    <dbReference type="GeneID" id="3373672"/>
    <dbReference type="KEGG" id="cpv:cgd2_2200"/>
    <dbReference type="InParanoid" id="Q5CTP4"/>
    <dbReference type="OMA" id="RMAYLKH"/>
    <dbReference type="OrthoDB" id="10259236at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.30:FF:000001">
        <property type="entry name" value="Ribosomal protein L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00547">
        <property type="entry name" value="Ribosomal_eL37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001569">
        <property type="entry name" value="Ribosomal_eL37"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011331">
        <property type="entry name" value="Ribosomal_eL37/eL43"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018267">
        <property type="entry name" value="Ribosomal_eL37_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10768:SF0">
        <property type="entry name" value="RIBOSOMAL PROTEIN L37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01907">
        <property type="entry name" value="Ribosomal_L37e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01077">
        <property type="entry name" value="RIBOSOMAL_L37E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 9 11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 9" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="5 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="16"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="101" mass="11474" checksum="CFB8E10E0EBAA538" modified="2005-04-12" version="1" fragment="single">SSSRNMGKAGKGTGSRGKHHGKTHFLCRRCGQRSYMVQKKRCASCGYPSAKMRSYNWGQKAKRRRTTGTGRMRHLKTMARRFKNGFREGTVARPLNMAAHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTU7</accession>
    <name>Q5CTU7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Possible translation initiation factor with possible PINT domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_1500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626372.1">
        <property type="nucleotide sequence ID" value="XM_626372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTU7"/>
    <dbReference type="FunCoup" id="Q5CTU7">
        <property type="interactions" value="488"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTU7"/>
    <dbReference type="GeneID" id="3373722"/>
    <dbReference type="KEGG" id="cpv:cgd2_1500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1500"/>
    <dbReference type="InParanoid" id="Q5CTU7"/>
    <dbReference type="OMA" id="HERFQIG"/>
    <dbReference type="OrthoDB" id="417252at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016650">
        <property type="entry name" value="eIF3e"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019010">
        <property type="entry name" value="eIF3e_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10317">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09440">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01186">
        <property type="entry name" value="eIF3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="5">
        <location>
            <begin position="275"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="511"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="540" mass="62964" checksum="D72FA4C235914FD1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTZ1</accession>
    <name>Q5CTZ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626328.1">
        <property type="nucleotide sequence ID" value="XM_626328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTZ1"/>
    <dbReference type="GeneID" id="3373600"/>
    <dbReference type="KEGG" id="cpv:cgd2_970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_970"/>
    <dbReference type="InParanoid" id="Q5CTZ1"/>
    <dbReference type="OMA" id="CLNISMI"/>
    <dbReference type="OrthoDB" id="338759at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="769" mass="89140" checksum="7FEF1917ADFCA8E6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU03</accession>
    <name>Q5CU03_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Golgi apparatus membrane protein TVP23 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the TVP23 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626316.1">
        <property type="nucleotide sequence ID" value="XM_626316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU03"/>
    <dbReference type="FunCoup" id="Q5CU03">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU03"/>
    <dbReference type="GeneID" id="3373608"/>
    <dbReference type="KEGG" id="cpv:cgd2_830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_830"/>
    <dbReference type="InParanoid" id="Q5CU03"/>
    <dbReference type="OMA" id="KMIWWID"/>
    <dbReference type="OrthoDB" id="2151161at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009306">
        <property type="term" value="P:protein secretion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008564">
        <property type="entry name" value="TVP23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13019:SF7">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05832">
        <property type="entry name" value="DUF846"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="150"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU361206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="226" mass="25835" checksum="D983B53FB0E3F49B" modified="2005-04-12" version="1">MNMELEFVGQSSLSNPAGMNQLNNVNHKNAMMNEDVAGAPIMASILNSATHPTICLFQVLFKVLAFLSFIFGPFFFRFFSNNSFILTFFLTSILLSLDFWTVKNVTGRILVGMRWWYEITKDGETVWMFENCNESKNTNTNVSSSTDKSVFWVTTYGWALLWVVIIVFQFLSLKFQWISLSVIAITLSFSNLIGYTKCIRSSRNIQKDWITNIAVKTIMSNAQNMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU07</accession>
    <name>Q5CU07_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626312.1">
        <property type="nucleotide sequence ID" value="XM_626312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU07"/>
    <dbReference type="GeneID" id="3373373"/>
    <dbReference type="KEGG" id="cpv:cgd2_780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_780"/>
    <dbReference type="InParanoid" id="Q5CU07"/>
    <dbReference type="OMA" id="NIFAMEP"/>
    <dbReference type="OrthoDB" id="339064at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="366" mass="42470" checksum="3CBC74109755A048" modified="2005-04-12" version="1">MSVTTASKPQYDAFRDEYSFSEGLSFDSFILVNDPRCKKPPQRIVKEEALSPIQLFLRPFMQCCAPRSRSEKKIKINISSYSTTTRTSIASIEIANKFGINENETENVETLSKQSKSIMWYILVPYEYGIPIITETQRQFACLLWGIKNEYGLVTTEKSIQKIFEAAKERRETSDIIKEYKSNPDLQIMKLHRDGLSVTVDEAFNEILSYYSPKYSILAIISRGRCFAFYSQASEDKTNVTYLLLDASSKYETGPRVFGFKDIKSLREHVISEFSHDHETRLKVSEGFRVTVFQGRVMWNTEFDMPNTIVKKDFKEKNEAMIRLGRLNDPKFDAKVVYGELQKATTRPTDQDYFFTYQNNMMKITK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU30</accession>
    <name>Q5CU30_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial phosphate translocator</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd2_520</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626289.1">
        <property type="nucleotide sequence ID" value="XM_626289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU30"/>
    <dbReference type="FunCoup" id="Q5CU30">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU30"/>
    <dbReference type="GeneID" id="3373659"/>
    <dbReference type="KEGG" id="cpv:cgd2_520"/>
    <dbReference type="InParanoid" id="Q5CU30"/>
    <dbReference type="OMA" id="TFREAVP"/>
    <dbReference type="OrthoDB" id="427452at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005315">
        <property type="term" value="F:phosphate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990547">
        <property type="term" value="P:mitochondrial phosphate ion transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000138">
        <property type="entry name" value="Mitochondrial phosphate carrier protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044677">
        <property type="entry name" value="SLC25A3/Pic2/Mir1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 (MITOCHONDRIAL CARRIER PHOSPHATE CARRIER), MEMBER 3, LIKE-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45671:SF10">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 25 MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="27"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="124"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="229"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="326" mass="36918" checksum="E380DCD0F881A95E" modified="2005-04-12" version="1" fragment="single">NEKTKLLKRSKFQNSVLLMKEKKRNVNYYLNCALGGALSCGLTHTAIVPIDVAKCRIQVYPDKFRSLVPTLSKIIRFEGVKALRLGWAPTLIGYSAQGALKYGLYEYFKDLYSSKILTTNKESHKGLIWLGASATAEFFADIALCPMEMIKIKMQTCTRPDLLPNSFLKSASNMYKYRSETKFPFGSIKPLWYRQIPYTMAKFYFFERINQMFYDKVFTKPKESYSKKSRLGITFLSGYLSGIICAIVSHPADTIISQLGKAAYNSSKRINVLSMTREIGIKNLCTAGLGTRIIMIGTLTGMQWWVYDSFKTIIGLNVSGKNKVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU41</accession>
    <name>Q5CU41_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Possible t-snare domain, possible transmembrane domain or GPI anchor signal at C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_4300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626973.1">
        <property type="nucleotide sequence ID" value="XM_626973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU41"/>
    <dbReference type="GeneID" id="3374055"/>
    <dbReference type="KEGG" id="cpv:cgd3_4300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4300"/>
    <dbReference type="InParanoid" id="Q5CU41"/>
    <dbReference type="OMA" id="CVRILCG"/>
    <dbReference type="OrthoDB" id="19261at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="9">
        <location>
            <begin position="120"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="222" mass="25650" checksum="1734345C25FCD802" modified="2005-04-12" version="1">MLLQELQFKFSKLDSLISRYEYLSKTKKFGDSTVSFCSQNINNALESIQIELKSLKEPSEKKKFEEFLNSRSDRIRNINESWTKNALIPTEQVTYNTKRNFNEDIQSLNDSDLTDYKKGDALIKLTDESIIRMKQSLTYTDKLGDDSLNKMNTQKEQLDRIRNELDNVKDNIYKANISLKAIARNTATDFCVQMLCGILSICLLIIIVLLVVLGIRKNKQSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUA8</accession>
    <name>Q5CUA8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd3_3560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Mitochondrion inner membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626906.1">
        <property type="nucleotide sequence ID" value="XM_626906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUA8"/>
    <dbReference type="STRING" id="353152.Q5CUA8"/>
    <dbReference type="GeneID" id="3373864"/>
    <dbReference type="KEGG" id="cpv:cgd3_3560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3560"/>
    <dbReference type="InParanoid" id="Q5CUA8"/>
    <dbReference type="OMA" id="YLKHYVH"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12823">
        <property type="entry name" value="Mrs2_Mfm1p-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.128.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.340">
        <property type="entry name" value="Magnesium transport protein CorA, transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039204">
        <property type="entry name" value="MRS2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890:SF0">
        <property type="entry name" value="MAGNESIUM TRANSPORTER MRS2 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13890">
        <property type="entry name" value="RNA SPLICING PROTEIN MRS2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22099">
        <property type="entry name" value="MRS2-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="9" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="544"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="577"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="500"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="605" mass="70205" checksum="1AB1853F1B24DCA4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUD3</accession>
    <name>Q5CUD3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mediator of RNA polymerase II transcription subunit 31</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_3300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the Mediator complex subunit 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626881.1">
        <property type="nucleotide sequence ID" value="XM_626881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUD3"/>
    <dbReference type="STRING" id="353152.Q5CUD3"/>
    <dbReference type="GeneID" id="3373868"/>
    <dbReference type="KEGG" id="cpv:cgd3_3300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3300"/>
    <dbReference type="InParanoid" id="Q5CUD3"/>
    <dbReference type="OMA" id="QGILNQP"/>
    <dbReference type="OrthoDB" id="10257739at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1340">
        <property type="entry name" value="Mediator of RNA polymerase II, submodule Med31 (Soh1)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038089">
        <property type="entry name" value="Med31_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008831">
        <property type="entry name" value="Mediator_Med31"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13186">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05669">
        <property type="entry name" value="Med31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0010">Activator</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 7" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="119" mass="14621" checksum="88134899EEE6A176" modified="2005-04-12" version="1">MLSEGESELLIEDENPIARFSLELEFVQCLSNPDYLQWLSKEGYFEDESFVNYLKYLLYWCEFPYVKYISYPHCIKMLRLLQIEDFRKNLSKEEVIQIIREQQTYQWIYSDIKKEHLKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUH6</accession>
    <name>Q5CUH6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Zinc finger double-stranded RNA binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_2800</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626838.1">
        <property type="nucleotide sequence ID" value="XM_626838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUH6"/>
    <dbReference type="STRING" id="353152.Q5CUH6"/>
    <dbReference type="GeneID" id="3373956"/>
    <dbReference type="KEGG" id="cpv:cgd3_2800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2800"/>
    <dbReference type="InParanoid" id="Q5CUH6"/>
    <dbReference type="OMA" id="GDECDAK"/>
    <dbReference type="OrthoDB" id="337427at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022755">
        <property type="entry name" value="Znf_C2H2_jaz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12171">
        <property type="entry name" value="zf-C2H2_jaz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger double-stranded RNA binding" evidence="5">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="143"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="153"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF12171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="196" mass="23015" checksum="E3CB1D92D4E493FF" modified="2005-04-12" version="1">MYKRVALFSSDLLSNSLNCKYLRENIEKQINKVYGDDFSDESPKNVEEHSDSLLKNEDIKTESIDSVEYDFIGKFKCILCPKKIIINESDLDKHIKSKQHLNMVEKWQKKQEDARKIREKFNILHNLTDGDKIIDEINPKNALSSGLTPNKQSNRKNKRRKSSNLSEEQIIAKKMKFVRKKERRLARKSQLTENIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUL5</accession>
    <name>Q5CUL5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Geranylgeranyl transferase type-2 subunit beta</fullName>
            <ecNumber evidence="8">2.5.1.60</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_2350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>geranylgeranyl diphosphate + L-cysteinyl-[protein] = S-geranylgeranyl-L-cysteinyl-[protein] + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21240"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11537"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57533"/>
            <dbReference type="ChEBI" id="CHEBI:86021"/>
            <dbReference type="EC" id="2.5.1.60"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="8">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 8">Belongs to the protein prenyltransferase subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.60" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626799.1">
        <property type="nucleotide sequence ID" value="XM_626799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUL5"/>
    <dbReference type="STRING" id="353152.Q5CUL5"/>
    <dbReference type="GeneID" id="3373920"/>
    <dbReference type="KEGG" id="cpv:cgd3_2350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2350"/>
    <dbReference type="InParanoid" id="Q5CUL5"/>
    <dbReference type="OMA" id="INSCASP"/>
    <dbReference type="OrthoDB" id="24893at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005968">
        <property type="term" value="C:Rab-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004663">
        <property type="term" value="F:Rab geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02894">
        <property type="entry name" value="GGTase-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.10.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045089">
        <property type="entry name" value="PGGT1B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001330">
        <property type="entry name" value="Prenyltrans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026873">
        <property type="entry name" value="Ptb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008930">
        <property type="entry name" value="Terpenoid_cyclase/PrenylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11774:SF11">
        <property type="entry name" value="GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00432">
        <property type="entry name" value="Prenyltrans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48239">
        <property type="entry name" value="Terpenoid cyclases/Protein prenyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2 8" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 8 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Prenyltransferase alpha-alpha toroid" evidence="9">
        <location>
            <begin position="22"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010497"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="395" mass="45864" checksum="F35FB2C94CE13751" modified="2005-04-12" version="1">MYNAARKFDLELHKKYLIFVTNDAINSYDSSKIQLSSVFIHGIYWVLCCSDLIQFNICDQLHNARNKFLHLLKKCERELLIDNFKLKFYSLNPFDFVRPSILSILSGIQIKTILNNKITEDNKYELTAFIKSLIALRGEKIYINNSKNCLRQFDVRFIYSTLLVYYLSNYPDLKQDSVFRISELTKLLVNMQNKDGGFGKRYKDESHAGYTFCAVSSIAIIKEITKNNSIDLLFNFNRLNRWLLKRIIASESHENTKYQSYCFNGRIGKKCDVCYSWWVFASLKIVKNITINRNIDCSSIINSKILKILINGILCHQNNIYGGFQKSPFNTDNKGHSDPLHTFLSISALSLIFNSDSKKSSLEFYEPTEPFEVFESLIKIDPISVISEKYLNKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUN5</accession>
    <name>Q5CUN5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleolar protein NOP5/NOP58-like pre-mRNA splicinig factor prp31</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_2110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626779.1">
        <property type="nucleotide sequence ID" value="XM_626779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUN5"/>
    <dbReference type="FunCoup" id="Q5CUN5">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUN5"/>
    <dbReference type="GeneID" id="3373785"/>
    <dbReference type="KEGG" id="cpv:cgd3_2110"/>
    <dbReference type="InParanoid" id="Q5CUN5"/>
    <dbReference type="OMA" id="MGMRSNW"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000005">
        <property type="entry name" value="Nucleolar protein 5, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.4070:FF:000001">
        <property type="entry name" value="Probable Nucleolar protein 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF1">
        <property type="entry name" value="NUCLEOLAR PROTEIN 58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="6">
        <location>
            <begin position="288"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="408"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="408"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="451"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="467" mass="51941" checksum="F4CF40350E1CC7FE" modified="2005-04-12" version="1" fragment="single">KMLVLLETPAGYGLFRVTNSKLLSMDTDEIAEYFQNPDKVQKSVSLEAFLRFKDTKSALVEATALVESKLSKGLSKFIKKNIPNPASESLAVADKVLGGLIKQKYEIDVVYNPKMQEVMRGIRNQLTDLLTGLTEKDMKTMALSLSHSLGRFKLKFSPEKIDTMIIQAVALLDDLDRELNNYAMRLKEWYGWHFPELGKIISDRDVYANCIKVIGFRHCTRDANLQSPPCNIPSEMEAEIKQAAEISMGTEITEEDLKNIIELCDRVLELSEYRESLSTYLKTRMSTIAPNLTYMVGELIGARLISHAGSLMNLAKHPSSTVQILGAEKALFRALKTKKSTPKYGLIYHAAVVGQSAPKLKGKISRILAAKLSLCIRVDALNDQNEPTVAIENKQYVERRLEELSNQLTSGRLSSTGGNKKPSTPSYSPVKSKALGSYDSSMDIVGSKRKPSGDSREEGSPDKRSKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUW8</accession>
    <name>Q5CUW8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible prefoldin-related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_1200</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626696.1">
        <property type="nucleotide sequence ID" value="XM_626696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUW8"/>
    <dbReference type="FunCoup" id="Q5CUW8">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUW8"/>
    <dbReference type="GeneID" id="3373838"/>
    <dbReference type="KEGG" id="cpv:cgd3_1200"/>
    <dbReference type="InParanoid" id="Q5CUW8"/>
    <dbReference type="OMA" id="KCYDTIT"/>
    <dbReference type="OrthoDB" id="248120at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23161">
        <property type="entry name" value="Prefoldin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002777">
        <property type="entry name" value="PFD_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21431:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01920">
        <property type="entry name" value="Prefoldin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="3"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="127" mass="14718" checksum="1FE8445E3D2CF6C2" modified="2005-04-12" version="1" fragment="single">AILEEIEVKMASTSNEHELITKEFLETQKKFEQINERRRILVAQESENQMVSKELELLESDAVIYKLVGSVMVKQSLDDAKSTVSKRLEYITGEIESVNKSFESLQSKLVEKSNQVSYNYQLFITFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUZ5</accession>
    <name>Q5CUZ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626669.1">
        <property type="nucleotide sequence ID" value="XM_626669.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUZ5"/>
    <dbReference type="GeneID" id="3374184"/>
    <dbReference type="KEGG" id="cpv:cgd3_880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_880"/>
    <dbReference type="InParanoid" id="Q5CUZ5"/>
    <dbReference type="OMA" id="RHIHVEK"/>
    <dbReference type="OrthoDB" id="335782at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="136" mass="15738" checksum="236B89A4A9957FB6" modified="2005-04-12" version="1">MVNINSPRKDLSVLAQCMNPVEEEMQEEQVFHPDSVILPPVSAVPFDYYPYSPRYKYPEVTCSYPFVSSPPYVVHYMSNLGVPSFFQQLDISIDQRRNVFQRNSGRNRGLQFEKGEENFGKYWSETQPSRPLGCMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVN7</accession>
    <name>Q5CVN7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Splicing factor SRP40 like 2x RRM domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd8_3370</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627232.1">
        <property type="nucleotide sequence ID" value="XM_627232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVN7"/>
    <dbReference type="FunCoup" id="Q5CVN7">
        <property type="interactions" value="462"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVN7"/>
    <dbReference type="GeneID" id="3374617"/>
    <dbReference type="KEGG" id="cpv:cgd8_3370"/>
    <dbReference type="InParanoid" id="Q5CVN7"/>
    <dbReference type="OMA" id="GHRKERT"/>
    <dbReference type="OrthoDB" id="1099063at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12339">
        <property type="entry name" value="RRM2_SRSF1_4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050374">
        <property type="entry name" value="RRT5_SRSF_SR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003">
        <property type="entry name" value="RNA RECOGNITION MOTIF RRM DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23003:SF62">
        <property type="entry name" value="SERINE_ARGININE (SR)-TYPE SHUTTLING MRNA BINDING PROTEIN NPL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254285" evidence="8">
        <location>
            <begin position="22"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="9">
        <location>
            <begin position="17"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="203"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="242"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="297"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="331"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="396"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="416" mass="47929" checksum="CF43EAAE30897671" modified="2005-04-12" version="1" fragment="single">FIIHTFLLLLDLLNNLGKVFVGNLPPGYAEQDLKDFFSKVGEIKKLELKQRFCFIEYEDETQAEAAHRELDGVEFGGQVIAVQPHDPMVRNKETNAANKPQYNRPLPSDGRGPPRKHFRVCVFNLDDNASWRDLKDYGRQIGEVNYSAVFHYQGQKVGVVEYLTVEEMKRALEEIPNLPFLGKSIRVEEDIGQLDRELAAANGYGAKRRSPPPFSSGPYNTGGRARGRYPSPSRFRMRSRSPRRDPYDRRERSHHYPDDRYRRGYEDRIPPPREDYYRRDEVRGGYPGERYPPPPYEDPRERYMHGSERFDDRYPGRAVPFDRRSPSRSGIGVGPIGGNGSMNVQRSGHYGGSTRGYYRDDDRDRERDRERDRRSANDQYSNSYYLRDDRDPPGSRPSGGYVSSGVPSGGRPNVAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVX6</accession>
    <name>Q5CVX6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription initiation factor IIF/ Rap30 like winged HTH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_2420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627143.1">
        <property type="nucleotide sequence ID" value="XM_627143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVX6"/>
    <dbReference type="GeneID" id="3374463"/>
    <dbReference type="KEGG" id="cpv:cgd8_2420"/>
    <dbReference type="InParanoid" id="Q5CVX6"/>
    <dbReference type="OMA" id="MYPSTIY"/>
    <dbReference type="OrthoDB" id="340799at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040450">
        <property type="entry name" value="TFIIF_beta_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02270">
        <property type="entry name" value="TFIIF_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIF beta subunit HTH" evidence="2">
        <location>
            <begin position="124"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="186" mass="21042" checksum="ED8DE341039154B2" modified="2005-04-12" version="1">MNTPDKPDKISMYPSKIHTLVRKGNFVTDDIRRRIKEKTKKSSTIEDTKRIVGAMYESNSQPFIYYDIKSDQMSDEPRNSSLSSIYKKKPATSSSQSSANIEGNNYSSGLSSSANNLNSSSLESLKENIFKIFEEKGSEGVSLKEIEDKTMKPKHILKKIVEEIAVQAGRGGRRHIWYLKPQFIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVX7</accession>
    <name>Q5CVX7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sey1p like P-loop GTpase of the RHD3 subfamily with a transmembrane domain near C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_2410</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable GTP-binding protein involved in generating and maintaining the structure of the tubular endoplasmic reticulum network.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627142.1">
        <property type="nucleotide sequence ID" value="XM_627142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVX7"/>
    <dbReference type="FunCoup" id="Q5CVX7">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVX7"/>
    <dbReference type="GeneID" id="3374393"/>
    <dbReference type="KEGG" id="cpv:cgd8_2410"/>
    <dbReference type="InParanoid" id="Q5CVX7"/>
    <dbReference type="OMA" id="PIIKMTE"/>
    <dbReference type="OrthoDB" id="1597724at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016320">
        <property type="term" value="P:endoplasmic reticulum membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01851">
        <property type="entry name" value="GBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03109">
        <property type="entry name" value="Sey1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030386">
        <property type="entry name" value="G_GB1_RHD3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008803">
        <property type="entry name" value="RHD3/Sey1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046758">
        <property type="entry name" value="Sey1/RHD3-like_3HB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45923:SF2">
        <property type="entry name" value="PROTEIN SEY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05879">
        <property type="entry name" value="RHD3_GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20428">
        <property type="entry name" value="Sey1_3HB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51715">
        <property type="entry name" value="G_GB1_RHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="769"/>
            <end position="799"/>
        </location>
    </feature>
    <feature type="domain" description="GB1/RHD3-type G" evidence="11">
        <location>
            <begin position="57"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="844" mass="97159" checksum="82979329778DCE8F" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVY0</accession>
    <name>Q5CVY0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDC45 like protein, possible horizontal transfer</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_2380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC45 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627139.1">
        <property type="nucleotide sequence ID" value="XM_627139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVY0"/>
    <dbReference type="STRING" id="353152.Q5CVY0"/>
    <dbReference type="GeneID" id="3374460"/>
    <dbReference type="KEGG" id="cpv:cgd8_2380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2380"/>
    <dbReference type="InParanoid" id="Q5CVY0"/>
    <dbReference type="OMA" id="IEISHAY"/>
    <dbReference type="OrthoDB" id="10258882at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031261">
        <property type="term" value="C:DNA replication preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902977">
        <property type="term" value="P:mitotic DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003874">
        <property type="entry name" value="CDC45"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507">
        <property type="entry name" value="CDC45-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10507:SF0">
        <property type="entry name" value="CELL DIVISION CONTROL PROTEIN 45 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02724">
        <property type="entry name" value="CDC45"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="706" mass="80810" checksum="7EC8DD66F3F33980" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW19</accession>
    <name>Q5CW19_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627100.1">
        <property type="nucleotide sequence ID" value="XM_627100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW19"/>
    <dbReference type="STRING" id="353152.Q5CW19"/>
    <dbReference type="GeneID" id="3374472"/>
    <dbReference type="KEGG" id="cpv:cgd8_1960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1960"/>
    <dbReference type="InParanoid" id="Q5CW19"/>
    <dbReference type="OrthoDB" id="343450at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="474"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="699" mass="81019" checksum="7047FC94286DBFF9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW60</accession>
    <name>Q5CW60_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_1520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_627059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW60"/>
    <dbReference type="STRING" id="353152.Q5CW60"/>
    <dbReference type="GeneID" id="3374588"/>
    <dbReference type="KEGG" id="cpv:cgd8_1520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1520"/>
    <dbReference type="InParanoid" id="Q5CW60"/>
    <dbReference type="OMA" id="ENAAQCE"/>
    <dbReference type="OrthoDB" id="8918678at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="47"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1183"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="630"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="743"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="948"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1093"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="8"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1183"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1196"/>
            <end position="1205"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1205" mass="139783" checksum="7BDCFA4D06B0C572" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW64</accession>
    <name>Q5CW64_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RPR domain containing protein, present in proteins involved in mRNA splicing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627055.1">
        <property type="nucleotide sequence ID" value="XM_627055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW64"/>
    <dbReference type="STRING" id="353152.Q5CW64"/>
    <dbReference type="GeneID" id="3374584"/>
    <dbReference type="KEGG" id="cpv:cgd8_1480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1480"/>
    <dbReference type="InParanoid" id="Q5CW64"/>
    <dbReference type="OrthoDB" id="377209at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="80"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="324" mass="38447" checksum="5B3A99B5DCF065B8" modified="2005-04-12" version="1">MVLSERMLNIPDNDPLCWIWIDLDGTINNMNSLEQNDDFMMLYNKYLEEIKENYDENLNVYEKFSSPIESLYYELSCERMPGNLEKSYERLLDSLTTKRMKINEIMTFVVDYSDQHSVQMIELLIQRFPNSTFEVKVSILYCISDILYNSHSSKIGAWKLRNCIMNIFPYLVSHISFQSNRGNSCYIDLINKTKSIIEIWIDWKIFPSEYIEGLSSSLCFDKMLDEMKNDKKTKLISNINDEISDGILLDKDIVSILSIWPIKSRLPVWKVWREMNNLLINKSLHEPKIRQDWVMNYGIVIAPLKLFGLTNFLHRISNWYNYRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW67</accession>
    <name>Q5CW67_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">11x WD40 repeats containing protein of plant origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_1450</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    </dbReference>
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        <property type="entry name" value="GPROTEINBRPT"/>
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        <property type="match status" value="11"/>
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        <property type="entry name" value="Putative isomerase YbhE"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="225"/>
            <end position="247"/>
        </location>
    </feature>
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        <location>
            <begin position="581"/>
            <end position="613"/>
        </location>
    </feature>
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        <location>
            <begin position="676"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="718"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="466"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="475"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
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        <source>
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        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1097" mass="123063" checksum="80886DCC442804D3" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW68</accession>
    <name>Q5CW68_CRYPI</name>
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        <submittedName>
            <fullName evidence="7">Nucleotide sugar transporter like integral membrane protein with 9 transmembrane domains</fullName>
        </submittedName>
    </protein>
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        <name evidence="7" type="ORF">cgd8_1440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
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            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_627051.1"/>
    </dbReference>
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    </dbReference>
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    <dbReference type="KEGG" id="cpv:cgd8_1440"/>
    <dbReference type="InParanoid" id="Q5CW68"/>
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        <property type="component" value="Chromosome 8"/>
    </dbReference>
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        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="EmrE-like"/>
    </dbReference>
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        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="7" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
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            <begin position="54"/>
            <end position="75"/>
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    </feature>
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        </location>
    </feature>
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            <end position="223"/>
        </location>
    </feature>
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        </location>
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    </feature>
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            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
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            <begin position="57"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="456" mass="51368" checksum="741A80BA750E9755" modified="2005-04-12" version="1" fragment="single">KLIGLSTPKPLIVNIEKIRLRRSAKNHSVLDKSTVVKLKMEKGKENETFQFKKALSLILYGLVSVALVFLNKRIFIGSFSYPLFTTWIQQVCGMIFYLIAYATLSLFGIDNLVSKPSIEYEKAKDCFPMSLSCTIFILLSNLCLKYVPMSSYAITRSLTLFFNIIFSIFILKQQISTICIFGCGIVILGFIIGSLDSSTLGFYGILSGTTSSLFQSIYTVQIKSVSKKINDESQVYWYNALTTSFLAAIPIFIFGEHNAFIELYTLDFGEFIIKFGPILISGILNFFLGIIIIWCIHTTSPIAYNLTGYVKSGAQTLIGVLLNNEELKFSTILGLVMTIGGSAIYSFSNLFKFIPNKNIDLNESFNITFGHQLQQQEPIQQENYYDHDSTISGSSSLEYDSGKKPEINDNFYDNEHFNSSNNYDQLIKNSKYRKVSQIGSLDENLINYSKSNGEIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWM6</accession>
    <name>Q5CWM6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative low complexity protein with signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627778.1">
        <property type="nucleotide sequence ID" value="XM_627778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWM6"/>
    <dbReference type="SMR" id="Q5CWM6"/>
    <dbReference type="GeneID" id="3375786"/>
    <dbReference type="KEGG" id="cpv:cgd6_4470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4470"/>
    <dbReference type="InParanoid" id="Q5CWM6"/>
    <dbReference type="OMA" id="WHTIELT"/>
    <dbReference type="OrthoDB" id="337716at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254581" evidence="1">
        <location>
            <begin position="21"/>
            <end position="725"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="725" mass="82718" checksum="9DD9DADB3EBD4655" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWM8</accession>
    <name>Q5CWM8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_4450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Heterohexamer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Intermembrane side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small Tim family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627776.1">
        <property type="nucleotide sequence ID" value="XM_627776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWM8"/>
    <dbReference type="FunCoup" id="Q5CWM8">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="3375911"/>
    <dbReference type="KEGG" id="cpv:cgd6_4450"/>
    <dbReference type="InParanoid" id="Q5CWM8"/>
    <dbReference type="OMA" id="ITMVEDT"/>
    <dbReference type="OrthoDB" id="344165at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.810">
        <property type="entry name" value="Mitochondrial import inner membrane translocase subunit tim13 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004217">
        <property type="entry name" value="Tim10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035427">
        <property type="entry name" value="Tim10-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02953">
        <property type="entry name" value="zf-Tim10_DDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144122">
        <property type="entry name" value="Tim10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Tim10-like" evidence="2">
        <location>
            <begin position="46"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU367043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="121" mass="13768" checksum="05363A6FFECEBDB9" modified="2005-04-12" version="1" fragment="single">RVYYWRQISKVKKEIEGIKLKRKGLIMEGEKENSSIQAIEKLQLLQRVVESQKMMAKLTSRCYKKCVVGGSGGGGKSLTRKEKLCLWNCAQNFLESSEFVASRITMVEDTSLSNQKDSEKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWP4</accession>
    <name>Q5CWP4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627760.1">
        <property type="nucleotide sequence ID" value="XM_627760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWP4"/>
    <dbReference type="STRING" id="353152.Q5CWP4"/>
    <dbReference type="GeneID" id="3375772"/>
    <dbReference type="KEGG" id="cpv:cgd6_4280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4280"/>
    <dbReference type="InParanoid" id="Q5CWP4"/>
    <dbReference type="OMA" id="MIINDEY"/>
    <dbReference type="OrthoDB" id="340803at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255033" evidence="1">
        <location>
            <begin position="28"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="456" mass="52470" checksum="E969BE40B865C817" modified="2007-04-03" version="1">MNKHRNFLRKLCSGPILLLIILSLSNSTEVDKAINFKENLQSKESTFSTGLRIPNYNNHSEICRLCGCDSTKNVNVEGFKSFTCSNCNKSKIQEGDCILQGAINDSNNNKTELVHGLETSVFGDYRSLFFGKSDFLTSRSYRNNLLARIFEPEFTWENFSHGSIKDNCKIYRDENDDFEHFKLSFTYTLHGDRNCTRLLLHFVNKHTGSTLYKNLSPFKEIESDYDLNSLMVFRHDDIKVRVDSLEKVNLHQEFNITSYDSPPKFLFSSEQQEWVPVSLRNQEIIVNPKIIHERLLIIFQLINSQSSTPSCKMDNVKVEVVVQCKSVAFPPNPKYNKDFVQDKLKKMHSKYDDKIFKLFLQKFEEKLMHVLGSIPNALLTTNSNKLITNTPLSNFSIPCKEAIYLGDIPKLMTKFNYTSKFNELANSGSYSTSTPTFEDVDENKLFNDIEAALNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWV3</accession>
    <name>Q5CWV3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">26S proteasome regulatory subunit Rpn6-like PINT domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_3590</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627701.1">
        <property type="nucleotide sequence ID" value="XM_627701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWV3"/>
    <dbReference type="FunCoup" id="Q5CWV3">
        <property type="interactions" value="430"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWV3"/>
    <dbReference type="GeneID" id="3375722"/>
    <dbReference type="KEGG" id="cpv:cgd6_3590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3590"/>
    <dbReference type="InParanoid" id="Q5CWV3"/>
    <dbReference type="OMA" id="ESKIYHA"/>
    <dbReference type="OrthoDB" id="1418352at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050871">
        <property type="entry name" value="26S_Proteasome/COP9_Components"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040773">
        <property type="entry name" value="Rpn6_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10678">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 11/COP9 SIGNALOSOME COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18055">
        <property type="entry name" value="RPN6_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00753">
        <property type="entry name" value="PAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="223"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="422" mass="48798" checksum="F33A3DC0F3C8642E" modified="2007-04-03" version="1">MEISIKDDFEKAKSLMETDFKLSIPILIELIKKDNLDEIEDGTKIQEQAIYTLGEIYMKQGMANELKELIKTIRPIIGGLPKARVAKIIRNLMDMMSKIPDTEKLQEQLCLECIEWCLEEKRTFLRHRITARLAMVYLNSSQFVKGLDYIEKLIKEVKKVDDKILLVEAYLIESKLEYRIRNLPKSKAALTAARTNANSIHCPPLLQADIDLQSGIILADEEDFKTSFSYFYEAFEAFNIANDERALQSLKYMLLSKIMSQQTNNLASLLSGKNKVKFQMREIEALRMVASCCENRSLSMFEDVLKNYETELSSDMVIHRHINNLYESLMEQNILRILESYSHIEISQLALFLNLSSERVYSKVIEMILNKLIQGNIDQRTEVLTIYDENQNSNLKIPELISTFDNLSNVVDVLYEKATRTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX89</accession>
    <name>Q5CX89_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">AMP-activated protein kinase beta chain (Has isoamylase N-terminal domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_2050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 5'-AMP-activated protein kinase beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627565.1">
        <property type="nucleotide sequence ID" value="XM_627565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX89"/>
    <dbReference type="STRING" id="353152.Q5CX89"/>
    <dbReference type="GeneID" id="3376075"/>
    <dbReference type="KEGG" id="cpv:cgd6_2050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2050"/>
    <dbReference type="InParanoid" id="Q5CX89"/>
    <dbReference type="OMA" id="CENGIPT"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031588">
        <property type="term" value="C:nucleotide-activated protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050827">
        <property type="entry name" value="CRP1_MDG1_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10343:SF84">
        <property type="entry name" value="5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="2">
        <location>
            <begin position="38"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="284" mass="33202" checksum="812B750B98A899C3" modified="2007-04-03" version="1">MGIVSSSSNLSSIDKPNEQNNFHCTNGHMNGHNLENIQCVIRWSFGGDEVFVTGSFNFWRKQDEYKLFKSGHDHLIAIELTRNIHFFKFIVDGEWRYSPEYPIESDSEGYINNCIDLTKYKAPYYSTPCDKSRYGVQEFHQELPTEFPVDAPALPILLGKSRCPLETANGIHIPFHCISNHIYYDSLVQEIFGTHIVTFCVTKRWFKEKYMQIDHCMQKFTTILYVSFRLIDEFYPILICKKNDYNLNCFSKSVSDSENNNPHYDAYFSDRLLTTAEMFATIFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXC7</accession>
    <name>Q5CXC7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Micro-fibrillar-associated protein 1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627527.1">
        <property type="nucleotide sequence ID" value="XM_627527.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXC7"/>
    <dbReference type="GeneID" id="3376110"/>
    <dbReference type="KEGG" id="cpv:cgd6_1600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1600"/>
    <dbReference type="InParanoid" id="Q5CXC7"/>
    <dbReference type="OrthoDB" id="339751at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009730">
        <property type="entry name" value="MFAP1_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06991">
        <property type="entry name" value="MFAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Micro-fibrillar-associated protein 1 C-terminal" evidence="1">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06991"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="102" mass="12313" checksum="8056F65BC5A0FC99" modified="2005-04-12" version="1">MNRPKYISKLRRKTIIIEKNRSQTINETIKSSLNIKDELSDVSCTRIDTECELKNQKDKPSKVDGHDEINRKLDYLRWKEREYKRLKGEYFDYMVNSKCNHT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXD6</accession>
    <name>Q5CXD6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Polycystin cation channel PKD1/PKD2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627518.1">
        <property type="nucleotide sequence ID" value="XM_627518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXD6"/>
    <dbReference type="GeneID" id="3376016"/>
    <dbReference type="KEGG" id="cpv:cgd6_1510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1510"/>
    <dbReference type="InParanoid" id="Q5CXD6"/>
    <dbReference type="OMA" id="RRICAYK"/>
    <dbReference type="OrthoDB" id="438129at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005262">
        <property type="term" value="F:calcium channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050982">
        <property type="term" value="P:detection of mechanical stimulus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051223">
        <property type="entry name" value="Polycystin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877:SF194">
        <property type="entry name" value="LOCATION OF VULVA DEFECTIVE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10877">
        <property type="entry name" value="POLYCYSTIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="352"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="481"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="542"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="581"/>
            <end position="602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="694" mass="79670" checksum="035777264E9A9DCB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXF5</accession>
    <name>Q5CXF5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627499.1">
        <property type="nucleotide sequence ID" value="XM_627499.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3376002"/>
    <dbReference type="KEGG" id="cpv:cgd6_1280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1280"/>
    <dbReference type="InParanoid" id="Q5CXF5"/>
    <dbReference type="OMA" id="KENDKHY"/>
    <dbReference type="OrthoDB" id="340444at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="342"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1554" mass="181714" checksum="03853ED293A8626C" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXG1</accession>
    <name>Q5CXG1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627493.1">
        <property type="nucleotide sequence ID" value="XM_627493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXG1"/>
    <dbReference type="GeneID" id="3376036"/>
    <dbReference type="KEGG" id="cpv:cgd6_1220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1220"/>
    <dbReference type="InParanoid" id="Q5CXG1"/>
    <dbReference type="OrthoDB" id="343922at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="128" mass="14706" checksum="71A12554260EAF85" modified="2007-04-03" version="1">MKQSNCEKEKNLIESISLNYSCKILAFINLNGCILVKKETLPINEKTIIIQQMNKYRLMLKSVTLKTKIIIGIILHIVLFIIALVFTRNRKYHKMTLKIYTNTKTESLEINSASELTTKVTLNTSNSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXT0</accession>
    <name>Q5CXT0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Small conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_5070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the MIP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628650.1">
        <property type="nucleotide sequence ID" value="XM_628648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXT0"/>
    <dbReference type="FunCoup" id="Q5CXT0">
        <property type="interactions" value="176"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXT0"/>
    <dbReference type="GeneID" id="3371750"/>
    <dbReference type="KEGG" id="cpv:cgd7_5070"/>
    <dbReference type="InParanoid" id="Q5CXT0"/>
    <dbReference type="OMA" id="NQCISAR"/>
    <dbReference type="OrthoDB" id="2746at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039796">
        <property type="entry name" value="MIP18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377:SF0">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12377">
        <property type="entry name" value="CYTOSOLIC IRON-SULFUR ASSEMBLY COMPONENT 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="128" mass="14783" checksum="D4683A8CD55174FC" modified="2005-04-12" version="1" fragment="single">DVYECIKDIIDPEYPLTLEQLNVVSLENIIINHEEQIIFVFFKPTVTSCSQASLIGLSLYYKLHTVFNKNFKIIIKVVKGTHDLEDSINKQLKDKERVHAALENPQIYKTITKGLANSDVWEDQSLLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXW5</accession>
    <name>Q5CXW5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628615.1">
        <property type="nucleotide sequence ID" value="XM_628613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXW5"/>
    <dbReference type="GeneID" id="3372190"/>
    <dbReference type="KEGG" id="cpv:cgd7_4670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4670"/>
    <dbReference type="InParanoid" id="Q5CXW5"/>
    <dbReference type="OMA" id="RQSKPIG"/>
    <dbReference type="OrthoDB" id="342456at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="151" mass="16632" checksum="D7FB6BEA36591F3F" modified="2005-04-12" version="1">MTKSSEMSGSVGGKNIEKLINSSLDDIVREAKKERQKKANLTQSRVRNGRGGKGQNLKKRGERRPNSVNSNGRRNFKGSPGKISRSRGGNRGRGFDQGKRMSRDQVKSIQIVAKLDSIPTPTAQQKAGLNNLEIIPSSISSQKARRNRVFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY44</accession>
    <name>Q5CY44_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Long chain fatty acyl diphosphate synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_3730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the FPP/GGPP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628536.1">
        <property type="nucleotide sequence ID" value="XM_628534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY44"/>
    <dbReference type="SMR" id="Q5CY44"/>
    <dbReference type="FunCoup" id="Q5CY44">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY44"/>
    <dbReference type="GeneID" id="3372121"/>
    <dbReference type="KEGG" id="cpv:cgd7_3730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3730"/>
    <dbReference type="InParanoid" id="Q5CY44"/>
    <dbReference type="OMA" id="NINAMKH"/>
    <dbReference type="OrthoDB" id="6921389at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990234">
        <property type="term" value="C:transferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004659">
        <property type="term" value="F:prenyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008299">
        <property type="term" value="P:isoprenoid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.600.10">
        <property type="entry name" value="Farnesyl Diphosphate Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008949">
        <property type="entry name" value="Isoprenoid_synthase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000092">
        <property type="entry name" value="Polyprenyl_synt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033749">
        <property type="entry name" value="Polyprenyl_synt_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001:SF69">
        <property type="entry name" value="ALL TRANS-POLYPRENYL-DIPHOSPHATE SYNTHASE PDSS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12001">
        <property type="entry name" value="GERANYLGERANYL PYROPHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00348">
        <property type="entry name" value="polyprenyl_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48576">
        <property type="entry name" value="Terpenoid synthases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00723">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00444">
        <property type="entry name" value="POLYPRENYL_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0414">Isoprene biosynthesis</keyword>
    <keyword evidence="5" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="466" mass="53786" checksum="4E784B97788845C6" modified="2005-04-12" version="1">MYKYIKNNELKKSLNLFKRSITITKNQLVKEFLVDLDDSCIRSEIFYPIRNLYHPPIDFINKNNPSDALFLKKKKINNWNELNNQEWSKILQNSTKCFRDNIANYIVNDDQNEFMLNENNAQRDLLQSQLLEFIPNEMKDIVKYVFQSEGKLTRQNYLSALVGLLKFAIGVNHSQPIGLDHRMLIHSIQLIHSASLLHDDILDNSEIRRGKKAPYKIFGNKKTILLGDYLFSKSCLNISIIENINAMKCISIIAENLVKGEFSQLNGLGSLIEGLNNSKDKKGLVGNYFEKYLLKSYYKTASLFSFGGIACSELLKKAYGNKLRMEMIIYSYYMGLNFGLAFQLMDDILDFTNSISQVNSGKPFFNDIKQGILTIPIYFLLLRDQERATKILVNTNFYNSDKAEILKDLVNILFDTNSIQASIVCVAQYLERYIHFINLISKSERNVFSSFLVKMADKLLKIIDDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY47</accession>
    <name>Q5CY47_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628533.1">
        <property type="nucleotide sequence ID" value="XM_628531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY47"/>
    <dbReference type="GeneID" id="3372119"/>
    <dbReference type="KEGG" id="cpv:cgd7_3700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3700"/>
    <dbReference type="InParanoid" id="Q5CY47"/>
    <dbReference type="OrthoDB" id="342211at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="151" mass="17611" checksum="17892BDB1EA00258" modified="2005-04-12" version="1">MVNVNELNLLSVDFNAELAINNLESVFLPKHTQSLDNISKAALLLPFAIQKELKLFNSCSTSSENNDDENLDKNINKAERQLNVIRNIEFKLNLKKKFSDKKKIFNSVSNKITDKFSIQPNKYFFQTEEKEKSDVYDYFTRKEVSISCYFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY57</accession>
    <name>Q5CY57_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Hs17p, histone methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_3600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628523.1">
        <property type="nucleotide sequence ID" value="XM_628521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY57"/>
    <dbReference type="FunCoup" id="Q5CY57">
        <property type="interactions" value="431"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY57"/>
    <dbReference type="GeneID" id="3372111"/>
    <dbReference type="KEGG" id="cpv:cgd7_3600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3600"/>
    <dbReference type="InParanoid" id="Q5CY57"/>
    <dbReference type="OMA" id="KIDNTRC"/>
    <dbReference type="OrthoDB" id="1368803at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.150">
        <property type="entry name" value="Divalent-metal-dependent TIM barrel enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035075">
        <property type="entry name" value="PRMT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035248">
        <property type="entry name" value="PRMT5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035247">
        <property type="entry name" value="PRMT5_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10738:SF0">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05185">
        <property type="entry name" value="PRMT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17286">
        <property type="entry name" value="PRMT5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17285">
        <property type="entry name" value="PRMT5_TIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PRMT5 TIM barrel" evidence="6">
        <location>
            <begin position="77"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 arginine-N-methyltransferase" evidence="5">
        <location>
            <begin position="305"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="PRMT5 oligomerisation" evidence="7">
        <location>
            <begin position="476"/>
            <end position="643"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="645" mass="74807" checksum="A9CD14C48C7A9920" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYD8</accession>
    <name>Q5CYD8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ABC transporter with ATpase domain plus 3 transmembrane regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd7_2730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628442.1">
        <property type="nucleotide sequence ID" value="XM_628440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYD8"/>
    <dbReference type="STRING" id="353152.Q5CYD8"/>
    <dbReference type="GeneID" id="3371936"/>
    <dbReference type="KEGG" id="cpv:cgd7_2730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2730"/>
    <dbReference type="InParanoid" id="Q5CYD8"/>
    <dbReference type="OMA" id="KQFHDME"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03223">
        <property type="entry name" value="ABCD_peroxisomal_ALDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050835">
        <property type="entry name" value="ABC_transporter_sub-D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384">
        <property type="entry name" value="ATP-BINDING CASSETTE, SUB-FAMILY D MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11384:SF59">
        <property type="entry name" value="LYSOSOMAL COBALAMIN TRANSPORTER ABCD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06472">
        <property type="entry name" value="ABC_membrane_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="125"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="87"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="481"/>
            <end position="704"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008575"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK90288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="704" mass="80776" checksum="5729FD944D0802E6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYK1</accession>
    <name>Q5CYK1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_2020</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628379.1">
        <property type="nucleotide sequence ID" value="XM_628377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYK1"/>
    <dbReference type="GeneID" id="3371885"/>
    <dbReference type="KEGG" id="cpv:cgd7_2020"/>
    <dbReference type="InParanoid" id="Q5CYK1"/>
    <dbReference type="OrthoDB" id="10434836at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="135" mass="15246" checksum="7AC239ECB406A36E" modified="2005-04-12" version="1">MDESANTKNETKEMNGNSHEIASIASSIFLFIHSAMELQCFSSISDVTKSFFLIASSFSGATLTQIPPAKIKRENTEQMNPKKFLPKKIINALNTVEATTDFHRDDPSRNPFIMQLHSVIFLSSYSFNFTKLINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYY8</accession>
    <name>Q5CYY8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RNA polymerase III subunit C11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_510</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628242.1">
        <property type="nucleotide sequence ID" value="XM_628240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYY8"/>
    <dbReference type="STRING" id="353152.Q5CYY8"/>
    <dbReference type="GeneID" id="3371769"/>
    <dbReference type="KEGG" id="cpv:cgd7_510"/>
    <dbReference type="InParanoid" id="Q5CYY8"/>
    <dbReference type="OMA" id="DFKWKEN"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006386">
        <property type="term" value="P:termination of RNA polymerase III transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10509">
        <property type="entry name" value="Zn-ribbon_RPC11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034014">
        <property type="entry name" value="Zn_ribbon_RPC11_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254565" evidence="8">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="9">
        <location>
            <begin position="20"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="62" mass="7510" checksum="B388A47E32BA36A2" modified="2005-04-12" version="1" fragment="single">IFANYFNNNFLFYWCSLFKLLAVCPKCSFSEAYFFQLQIRSADEPMTSFYTCVKCDFKWKEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPP1</accession>
    <name>A3FPP1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388387.1">
        <property type="nucleotide sequence ID" value="XM_001388350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPP1"/>
    <dbReference type="STRING" id="353152.A3FPP1"/>
    <dbReference type="MEROPS" id="S09.A16"/>
    <dbReference type="GeneID" id="3371829"/>
    <dbReference type="KEGG" id="cpv:cgd7_2550"/>
    <dbReference type="InParanoid" id="A3FPP1"/>
    <dbReference type="OMA" id="THLIQGA"/>
    <dbReference type="OrthoDB" id="10260961at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103:SF2">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42103">
        <property type="entry name" value="ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="54"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="230" mass="25102" checksum="5EF906CCE9175B33" modified="2007-04-03" version="1" fragment="single">MSNENSSLYPKQFSIHTSDGVKLSCRSFGNIPSKVPMTGIESIVFVLVHPYGIMGGSSSNMLGLALSLADKGYGSIIFDHRGIGKSTGYKSIFGNNEVYDVVSVCNDIKGKNSDIKVVLIGSSAGAPIAGSAVDECENVIGYIGIGYVFGFWPSLLFKQHYNNILRSKKHKLFIMGDSDGFTSIDVLKNKMDNCCDPKQVEIIPKVGHFELESPYYDDTICEIIDKFVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ05</accession>
    <name>A3FQ05_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_4700</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. BUD32 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388446.1">
        <property type="nucleotide sequence ID" value="XM_001388409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ05"/>
    <dbReference type="FunCoup" id="A3FQ05">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ05"/>
    <dbReference type="GeneID" id="3374360"/>
    <dbReference type="KEGG" id="cpv:cgd8_4700"/>
    <dbReference type="InParanoid" id="A3FQ05"/>
    <dbReference type="OMA" id="AYCEVHP"/>
    <dbReference type="OrthoDB" id="3399at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070525">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000201">
        <property type="entry name" value="TP53-regulating kinase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022495">
        <property type="entry name" value="Bud32"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03724">
        <property type="entry name" value="arch_bud32"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209:SF0">
        <property type="entry name" value="EKC_KEOPS COMPLEX SUBUNIT TP53RK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12209">
        <property type="entry name" value="NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="217" mass="24950" checksum="9FEA97247921BA57" modified="2007-04-03" version="1" fragment="single">RIYETTLLNKKVVIKHRFEKKYRHPQLDKSLKTSRILRESRNLVKCNQKGINCPNVHFVDVENGIIIMDYVQGTILNDYLNNIISNSSNYDSKLLDISISIGNAISKLHSHIIHGDLTTSNIIINDDSHDNQIIFIDFGLSYSDSLTIEDKAVDLYVLERSLEVTHPNIKIVSLIMKPTLYIFSPNFLFKKMDNILKAYCEVHPDGKSILNKYKQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ27</accession>
    <name>A3FQ27_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_2220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388107.1">
        <property type="nucleotide sequence ID" value="XM_001388070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ27"/>
    <dbReference type="FunCoup" id="A3FQ27">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ27"/>
    <dbReference type="GeneID" id="3374080"/>
    <dbReference type="KEGG" id="cpv:cgd3_2220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2220"/>
    <dbReference type="InParanoid" id="A3FQ27"/>
    <dbReference type="OMA" id="AEPHEDN"/>
    <dbReference type="OrthoDB" id="7851174at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23813">
        <property type="entry name" value="UBCc_UBE2N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000073">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2 N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="2"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="150" mass="17166" checksum="9EFB47FDBED16417" modified="2007-04-03" version="1">MSISKRIQKETMNLANDPSPGINAEPDEDNYRYFKIMMMGPEGTPYEGGSYKLELFLPEHYPMEPPKVRFLTKIYHPNIDKLGRICLDILKDKWSPALQIRTVLLSIQALLSSPEPNDPLDTVVADHFKNNLLDAESTAREWNRLYAKGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ47</accession>
    <name>A3FQ47_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-type ATPase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_3740</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388127.1">
        <property type="nucleotide sequence ID" value="XM_001388090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ47"/>
    <dbReference type="STRING" id="353152.A3FQ47"/>
    <dbReference type="GeneID" id="3373819"/>
    <dbReference type="KEGG" id="cpv:cgd3_3740"/>
    <dbReference type="InParanoid" id="A3FQ47"/>
    <dbReference type="OMA" id="INNEYEH"/>
    <dbReference type="OrthoDB" id="432719at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043682">
        <property type="term" value="F:P-type divalent copper transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055070">
        <property type="term" value="P:copper ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00371">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006121">
        <property type="entry name" value="HMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036163">
        <property type="entry name" value="HMA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520">
        <property type="entry name" value="ATP7, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43520:SF8">
        <property type="entry name" value="P-TYPE CU(+) TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00403">
        <property type="entry name" value="HMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55008">
        <property type="entry name" value="HMA, heavy metal-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50846">
        <property type="entry name" value="HMA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="354"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="409"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="485"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="727"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="784"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="domain" description="HMA" evidence="9">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1128" mass="129618" checksum="06EF315386529B97" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ50</accession>
    <name>A3FQ50_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Condensin complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd3_3960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CND2 (condensin subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388130.1">
        <property type="nucleotide sequence ID" value="XM_001388093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ50"/>
    <dbReference type="STRING" id="353152.A3FQ50"/>
    <dbReference type="GeneID" id="3373816"/>
    <dbReference type="KEGG" id="cpv:cgd3_3960"/>
    <dbReference type="InParanoid" id="A3FQ50"/>
    <dbReference type="OMA" id="FHNEMIS"/>
    <dbReference type="OrthoDB" id="362021at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022816">
        <property type="entry name" value="Condensin_barren_su2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13108:SF9">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05786">
        <property type="entry name" value="Cnd2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="7" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="8" id="KW-0498">Mitosis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="27"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="223"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00016065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="838" mass="96415" checksum="2FDE69358289944B" modified="2007-04-03" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ61</accession>
    <name>A3FQ61_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Flavohemoprotein b5+b5R (DJ676J13.1) (Flavohemoprotein b5+b5R cytochrome b-type NAD(P)H oxidoreductase), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_1040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cytochrome b5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388197.1">
        <property type="nucleotide sequence ID" value="XM_001388160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ61"/>
    <dbReference type="STRING" id="353152.A3FQ61"/>
    <dbReference type="GeneID" id="3373422"/>
    <dbReference type="KEGG" id="cpv:cgd2_1040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1040"/>
    <dbReference type="InParanoid" id="A3FQ61"/>
    <dbReference type="OMA" id="HCTANDC"/>
    <dbReference type="OrthoDB" id="260519at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004128">
        <property type="term" value="F:cytochrome-b5 reductase activity, acting on NAD(P)H"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020037">
        <property type="term" value="F:heme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.120.10">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001199">
        <property type="entry name" value="Cyt_B5-like_heme/steroid-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036400">
        <property type="entry name" value="Cyt_B5-like_heme/steroid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018506">
        <property type="entry name" value="Cyt_B5_heme-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051872">
        <property type="entry name" value="Cytochrome_b5/Flavoprotein_Rdt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237:SF1">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46237">
        <property type="entry name" value="CYTOCHROME B5 REDUCTASE 4 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00173">
        <property type="entry name" value="Cyt-b5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55856">
        <property type="entry name" value="Cytochrome b5-like heme/steroid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00191">
        <property type="entry name" value="CYTOCHROME_B5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50255">
        <property type="entry name" value="CYTOCHROME_B5_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0349">Heme</keyword>
    <keyword evidence="3 4" id="KW-0408">Iron</keyword>
    <keyword evidence="2 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytochrome b5 heme-binding" evidence="5">
        <location>
            <begin position="148"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="191" mass="21528" checksum="0CDE8A98A08C8EBD" modified="2007-04-03" version="1">MLLGQVCPSQMAGMGLKRSGLLVCKFADSEDLNLTWPGGQTKQNLVNYLDKSIRIHGKFCGDDLLEIEVSYLEEGDKVCWRATTLDELVEDCAFNIIRVVKQGNPNKAMITESATKIKGLKEGKRSSINQARYMGLMKDQEGSAPKQCRPITKEELKTHNSEKDCWISYQGKVYDITKYLEFHPGGKFDQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ65</accession>
    <name>A3FQ65_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUMO-activating enzyme subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd2_1460</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1 8">Protein modification; protein sumoylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388201.1">
        <property type="nucleotide sequence ID" value="XM_001388164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ65"/>
    <dbReference type="FunCoup" id="A3FQ65">
        <property type="interactions" value="598"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ65"/>
    <dbReference type="GeneID" id="3373454"/>
    <dbReference type="KEGG" id="cpv:cgd2_1460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1460"/>
    <dbReference type="InParanoid" id="A3FQ65"/>
    <dbReference type="OMA" id="TPSEHIH"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00886"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000002">
        <property type="entry name" value="SUMO-activating enzyme subunit 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.520">
        <property type="entry name" value="Ubiquitin activating enzymes (Uba3). Chain: B, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.20">
        <property type="entry name" value="Ubiquitin-like 2 activating enzyme e1b. Chain: B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028077">
        <property type="entry name" value="UAE_UbL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023318">
        <property type="entry name" value="Ub_act_enz_dom_a_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030661">
        <property type="entry name" value="Uba2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF5">
        <property type="entry name" value="SUMO-ACTIVATING ENZYME SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14732">
        <property type="entry name" value="UAE_UbL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039133">
        <property type="entry name" value="SUMO_E1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6 8 11" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="13">
        <location>
            <begin position="10"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-activating enzyme SCCH" evidence="14">
        <location>
            <begin position="301"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin/SUMO-activating enzyme ubiquitin-like" evidence="15">
        <location>
            <begin position="473"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="618"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="9">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="28"/>
            <end position="33"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="60"/>
            <end position="63"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="127"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="460"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="463"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR039133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR039133-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF10585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAZ51374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="637" mass="72108" checksum="84671D58FE93385E" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQA5</accession>
    <name>A3FQA5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">deoxyhypusine synthase</fullName>
            <ecNumber evidence="5">2.5.1.46</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_3930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>[eIF5A protein]-L-lysine + spermidine = [eIF5A protein]-deoxyhypusine + propane-1,3-diamine</text>
            <dbReference type="Rhea" id="RHEA:33299"/>
            <dbReference type="Rhea" id="RHEA-COMP:10143"/>
            <dbReference type="Rhea" id="RHEA-COMP:10144"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57484"/>
            <dbReference type="ChEBI" id="CHEBI:57834"/>
            <dbReference type="ChEBI" id="CHEBI:82657"/>
            <dbReference type="EC" id="2.5.1.46"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; eIF5A hypusination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the deoxyhypusine synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.46" evidence="5"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388241.1">
        <property type="nucleotide sequence ID" value="XM_001388204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQA5"/>
    <dbReference type="FunCoup" id="A3FQA5">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQA5"/>
    <dbReference type="GeneID" id="3373666"/>
    <dbReference type="KEGG" id="cpv:cgd2_3930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3930"/>
    <dbReference type="InParanoid" id="A3FQA5"/>
    <dbReference type="OMA" id="HSIINAN"/>
    <dbReference type="OrthoDB" id="294378at2759"/>
    <dbReference type="BioCyc" id="MetaCyc:MONOMER-18750"/>
    <dbReference type="BRENDA" id="2.5.1.46">
        <property type="organism ID" value="1728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034038">
        <property type="term" value="F:deoxyhypusine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.910.10:FF:000001">
        <property type="entry name" value="Probable deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.910.10">
        <property type="entry name" value="Deoxyhypusine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002773">
        <property type="entry name" value="Deoxyhypusine_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036982">
        <property type="entry name" value="Deoxyhypusine_synthase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00321">
        <property type="entry name" value="dhys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11703:SF0">
        <property type="entry name" value="DEOXYHYPUSINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01916">
        <property type="entry name" value="DS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0386">Hypusine biosynthesis</keyword>
    <keyword evidence="7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012683"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="362" mass="40836" checksum="462A55AF43BDD784" modified="2007-04-03" version="1">MHSLGNSGDIPDMAKNSVLLHSEPIDDNSRKVLGPSKNKFTDITIKEYCKDIKKMGFQATNIGRAIDEINKMLSWRLSDENIEPDEVEPYNDLEYRKNVKCTIWLSFTSNMISSGLREIFVYLAKNKLIDVIVTSAGGIEEDFIKVLGSTFLGEFNLKGSELRNKGWNRIGNLLVPNQNYVDFEEWIQPLFDEMLEMQNKDSINWTPSKMIHFLGEKINHDESLYYWCYKNNIPVFCPGITDGSLGDNLFFHSYRNPGLKVDVVEDIRRINDIALNIKKSGIIILGGGIPKHHTCNANLMRNGADYAVYISSATEFDGSDSGASPDEAVSWGKIKAESTPVKVFGDATIIFPLIFYSTFLDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQE9</accession>
    <name>A3FQE9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ankyrin-related protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_2670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388171.1">
        <property type="nucleotide sequence ID" value="XM_001388134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQE9"/>
    <dbReference type="STRING" id="353152.A3FQE9"/>
    <dbReference type="GeneID" id="3371397"/>
    <dbReference type="KEGG" id="cpv:cgd1_2670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2670"/>
    <dbReference type="InParanoid" id="A3FQE9"/>
    <dbReference type="OMA" id="MMACCGH"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051616">
        <property type="entry name" value="Cul2-RING_E3_ligase_SR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46224:SF6">
        <property type="entry name" value="ANKYRIN REPEAT FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAZ51348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="503" mass="55842" checksum="047CF045085CDFA5" modified="2007-04-03" version="1">MSCVKSKEDSNLGDAYGDITRLFSTVTNGTTVEAIKYIVALVGSSKEKMDIEEHLLGYKDGNGRNVCHFVCSAKRNDTLKAIIKLAPGIVNSLDNSNENPLFLSVRAQDIESVTTLLKSGVEITRKNSSGCNVLHYACQVADLNLVKLIISSLKSENPSEIDLFVNTCSDEFGTPLQWACMTNNKELISYLLNNKSNPNKAPLGKLIPSPLMITIGIGNTELTELLLKSGALLAEAMDSEGYTPIFAAVEKNDVELLSLIIKYMKLQLCDASNQIVKGNSIYSYAINNRCSEEIMEILKSHALDSIKIDNIQQIEQGQSTQIESIESIESSEYSSLNDEKKSSEPDISPEVIIEQDLEDISNYNEVEAERLKAEANSFFKEGQFEKSIEMYSNALSHLMMKKNNLSEGAITLKSSILSNRSLSYIKIGDSSKALFDATSCIYINPKWSKGYYRCSQVYHMIGDVANQACYLWDAITNENSNSALKQEYLDAFSQIMKKHRQSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQI2</accession>
    <name>A3FQI2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MORN repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388266.1">
        <property type="nucleotide sequence ID" value="XM_001388229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQI2"/>
    <dbReference type="STRING" id="353152.A3FQI2"/>
    <dbReference type="GeneID" id="3373359"/>
    <dbReference type="KEGG" id="cpv:cgd5_1640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1640"/>
    <dbReference type="InParanoid" id="A3FQI2"/>
    <dbReference type="OMA" id="FEGSYVK"/>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43215:SF14">
        <property type="entry name" value="RADIAL SPOKE HEAD 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="309" mass="34154" checksum="BD6F6F27E25F3021" modified="2007-04-03" version="1">MSGVSRRAVITDPNGVYEGDVNEKGLKHGNGVYKVNTGDVYEGEYSNGLKNGYGVYTWANGDKFEGYYKDDIKWGHGIYRWSNGEVFEGEYVRGVKCGHGIYTWPNGDRFEGEYKDGVKEGFGVYKLATGRIYEGQYSRDMRNGQGTSRYTDGSVYTGEWFDGKEHGHGLLKFSDSSSYEGDFQNGAPNGQGKYTYSNGNYYVGGFKNGLTDGPGSLTFAEDNRVLKANWKDGQVDGDAAIIYPDGGKYTGEVVNGIRQGKGIMTESNGDIFDGEFFRDFRHGEGILTVNGKQKRVKYNMGKKVGLCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQJ5</accession>
    <name>A3FQJ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_3000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388279.1">
        <property type="nucleotide sequence ID" value="XM_001388242.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQJ5"/>
    <dbReference type="STRING" id="353152.A3FQJ5"/>
    <dbReference type="GeneID" id="3373325"/>
    <dbReference type="KEGG" id="cpv:cgd5_3000"/>
    <dbReference type="InParanoid" id="A3FQJ5"/>
    <dbReference type="OMA" id="NIPDPRN"/>
    <dbReference type="OrthoDB" id="515366at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.740">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAZ51301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="95" mass="11116" checksum="A960F68034DFCDED" modified="2007-04-03" version="1" fragment="single">INIKPLSLPYYFPYFFPNYSENNELIVQLSKMRKGSVWNSVIASNENSLNSIDIENMKKQMMLERFQRENPGFDFSNAEFNGNIPDPRNFMGGLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPD8</accession>
    <name>Q5CPD8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_4550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000018">
        <property type="protein sequence ID" value="EAK87290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625303.1">
        <property type="nucleotide sequence ID" value="XM_625303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPD8"/>
    <dbReference type="GeneID" id="3372303"/>
    <dbReference type="KEGG" id="cpv:cgd5_4550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4550"/>
    <dbReference type="InParanoid" id="Q5CPD8"/>
    <dbReference type="OrthoDB" id="10425531at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254774" evidence="1">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="141" mass="15406" checksum="C94C19BF3910B423" modified="2005-04-12" version="1">MKVLSLIKLFTLFLINIINIHDINQYFSIISKSSFITLKSSLRGNNESKDNHDGITACGNKTPNCVGGYYITDNQSDTNNESKVSHDGITPCGNETPNCVGGYYITDNQSDTNNESKVSHDGITPCGNKTPNCVGGYYINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPE2</accession>
    <name>Q5CPE2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_4510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000018">
        <property type="protein sequence ID" value="EAK87288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625299.1">
        <property type="nucleotide sequence ID" value="XM_625299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPE2"/>
    <dbReference type="STRING" id="353152.Q5CPE2"/>
    <dbReference type="GeneID" id="3372301"/>
    <dbReference type="KEGG" id="cpv:cgd5_4510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4510"/>
    <dbReference type="InParanoid" id="Q5CPE2"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254075" evidence="1">
        <location>
            <begin position="19"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="262" mass="31212" checksum="CE8B6FAC561CF18A" modified="2005-04-12" version="1">MNFINYLILLLLFKYTYGLTFFDIFYPPDSHHITFYEGHFVPYDINNNTMNGTDNNNYLVAITQGNELLTFPFLNKYNITLNCNKADPHPFNIEAGLRKFIIKKSDFDVLRIIFYNNINKNFLLGKIFCASKLILDVENNKFRITPITNDVDRPSIPAFSLVAKYYSYQLKEIPELPKYLRDFDEKIIKSEDIINFVKEQEPEYIDNLNNKIIFKEFYNNEEKLTSYKNDLHKDKIFFVIFEYNDDINNNHYYIGVPLQKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPI7</accession>
    <name>Q5CPI7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Atg6 BARA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the beclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625362.1">
        <property type="nucleotide sequence ID" value="XM_625362.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPI7"/>
    <dbReference type="STRING" id="353152.Q5CPI7"/>
    <dbReference type="GeneID" id="3375643"/>
    <dbReference type="KEGG" id="cpv:cgd6_230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_230"/>
    <dbReference type="InParanoid" id="Q5CPI7"/>
    <dbReference type="OMA" id="WTKAMKC"/>
    <dbReference type="OrthoDB" id="20368at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043548">
        <property type="term" value="F:phosphatidylinositol 3-kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045324">
        <property type="term" value="P:late endosome to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.40">
        <property type="entry name" value="Autophagy protein 6/Beclin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007243">
        <property type="entry name" value="Atg6/Beclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038274">
        <property type="entry name" value="Atg6/Beclin_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040455">
        <property type="entry name" value="Atg6_BARA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768">
        <property type="entry name" value="BECLIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12768:SF4">
        <property type="entry name" value="BECLIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04111">
        <property type="entry name" value="APG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Atg6 BARA" evidence="2">
        <location>
            <begin position="264"/>
            <end position="432"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="443" mass="51246" checksum="7AAB05E254708630" modified="2005-04-12" version="1">MFLLGLGSKKIEKLEDDPKVEENMIRSCSRCGSFFEVVNDSDDELDPSEIINTVESVHDMFIDYLSLEKRNPNNFEDFILQFMEVSLEKDNMTLSNKTNVEESLCVDCMNCSISQFSMALNKEISLLDKYKEISDSLISSECYDEDQMEDSEVNFEPTSKEYLEIMNIYNEFIKMEQYNQEKTIINDENDNDEIDCTETDKDIKEGYGKCRFQVINTIEVDDIVELRQNQNLESNLKHELIQYELKREGMKNHLDFLRGYLERLKRSDFLNLSFYIQVIEGGACINGLRPALFEADFDNWNEVNAALGVSAMLLYTILERHKLPLSIYPNGSYSTIKDSESSIWPLHGNTLCNSDYNECTNFDKGILSFVFLIDTVYNIIPGTNETLPYSVDQRNGTIGGISLNLLFNERESWNRAMSMNLINLKWLLVRSSESIRNKLNNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPJ7</accession>
    <name>Q5CPJ7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd6_120</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625352.1">
        <property type="nucleotide sequence ID" value="XM_625352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPJ7"/>
    <dbReference type="SMR" id="Q5CPJ7"/>
    <dbReference type="FunCoup" id="Q5CPJ7">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPJ7"/>
    <dbReference type="GeneID" id="3375635"/>
    <dbReference type="KEGG" id="cpv:cgd6_120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_120"/>
    <dbReference type="InParanoid" id="Q5CPJ7"/>
    <dbReference type="OMA" id="CTTHSET"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02982">
        <property type="entry name" value="PDI_b'_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02981">
        <property type="entry name" value="PDI_b_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005792">
        <property type="entry name" value="Prot_disulphide_isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01130">
        <property type="entry name" value="ER_PDI_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13848">
        <property type="entry name" value="Thioredoxin_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9 10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253710" description="protein disulfide-isomerase" evidence="11">
        <location>
            <begin position="25"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="22"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="12">
        <location>
            <begin position="328"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="62"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="10">
        <location>
            <begin position="391"/>
            <end position="394"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR605792-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK87340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="481" mass="53789" checksum="0683945F4ECB8C5E" modified="2007-04-03" version="1">MIGIRSLVSAAFLGFSCLSKVVLGGDEAHFISEHITSLTSSNFEDFIKSKEHVIVTFFAPWCGHCTALEPEFKATCAEISKLSPPVHCGSVDATENMELAQQYGVSGYPTIKFFSGIDSVQNYSGARSKDAFIKYIKKLTGPAVQVAESEEAIKTIFASSSSAFVGRFTSKDSAEYAVFEKVASGHREHNYAFIAFFQEGEQKLEVLHKDEEPVSLPMPKTVEELEAKISIMNVPLFSAISAENYSLYMSREGYTAWFCGTNEDFAKYASNIRKVAADYREKYAFVFLDTEQFGSHATQHLLIEKFPGLVIQSVNVPSIRYMYGPAKFDSVEPLKEFMKQVSEGKHELSIKSEPIPAEQSGPVTVVVGKTFEEIVFRSDKDVLLEIYAQWCGHCKNLEPIYNQLGEEYKDNDKVVIAKINGPQNDIPYEGFSPRAFPTILFVKAGTRTPIPYDGKRTVEAFKEFISEHSSFPQEKESRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPN5</accession>
    <name>Q5CPN5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40s ribosomal protein s24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625386.1">
        <property type="nucleotide sequence ID" value="XM_625386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPN5"/>
    <dbReference type="FunCoup" id="Q5CPN5">
        <property type="interactions" value="403"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPN5"/>
    <dbReference type="GeneID" id="3372347"/>
    <dbReference type="KEGG" id="cpv:cgd2_170"/>
    <dbReference type="InParanoid" id="Q5CPN5"/>
    <dbReference type="OMA" id="IRVKKYM"/>
    <dbReference type="OrthoDB" id="10251131at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00545">
        <property type="entry name" value="Ribosomal_eS24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053709">
        <property type="entry name" value="eRP_eS24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001976">
        <property type="entry name" value="Ribosomal_eS24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012678">
        <property type="entry name" value="Ribosomal_uL23/eL15/eS24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10496">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01282">
        <property type="entry name" value="Ribosomal_S24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54189">
        <property type="entry name" value="Ribosomal proteins S24e, L23 and L15e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="133"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="159" mass="17947" checksum="F4452CFE3F94AC5A" modified="2005-04-12" version="1" fragment="single">LSGIIFLNKKKFFQDKFGVVFKNSKNITMNNFTVRVRQFLNNPLLARKQFVVDVIHPSLGGVSKSDLKAKLAKLYKVQDANCIVLFGFKTAFGGGRSSGFCVIYNNISALKKFEHRYRQVRMGIAEKVTATGRKGRKETKNRRKKVRGTEKAKISGGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPN9</accession>
    <name>Q5CPN9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S acidic ribosomal protein LP2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625382.1">
        <property type="nucleotide sequence ID" value="XM_625382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPN9"/>
    <dbReference type="FunCoup" id="Q5CPN9">
        <property type="interactions" value="201"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPN9"/>
    <dbReference type="GeneID" id="3372370"/>
    <dbReference type="KEGG" id="cpv:cgd2_130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_130"/>
    <dbReference type="InParanoid" id="Q5CPN9"/>
    <dbReference type="OMA" id="MKVIASY"/>
    <dbReference type="OrthoDB" id="1227494at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002182">
        <property type="term" value="P:cytoplasmic translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05833">
        <property type="entry name" value="Ribosomal_P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000002">
        <property type="entry name" value="60S acidic ribosomal protein P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044076">
        <property type="entry name" value="Ribosomal_P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21141:SF5">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="75"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="75"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="112" mass="11511" checksum="8002B717F22C5746" modified="2005-04-12" version="1">MGMKYVAAYLLCVSSGKEQPTASDIKKVLESVGIEYDQSIIDVLISNMSGKLSHEVIASGLSKLQSVPTGGVAVSGGAAAASGGAAQDSAPAEKKKEEEEEEEGDLGFSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPP8</accession>
    <name>Q5CPP8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Heat shock 70 (HSP70) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_20</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2009-11" db="PDB data bank">
            <title>Crystal structure of the N-terminal domain of Hsp70 (cgd2_20) from Cryptosporidium parvum in complex with AMPPNP.</title>
            <authorList>
                <consortium name="Structural Genomics Consortium (SGC)"/>
                <person name="Wernimont A.K."/>
                <person name="Hutchinson A."/>
                <person name="Sullivan H."/>
                <person name="Lew J."/>
                <person name="Bochkarev A."/>
                <person name="Arrowsmith C.H."/>
                <person name="Bountra C."/>
                <person name="Weigelt J."/>
                <person name="Edwards A.M."/>
                <person name="Hui R."/>
                <person name="Pizarro J.C."/>
                <person name="Hills T."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 15-396</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2009-12" db="PDB data bank">
            <title>CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HSP70 (CGD2_20) FROM Cryptosporidium PARVUM IN COMPLEX WITH ADP and inorganic phosphate.</title>
            <authorList>
                <person name="Pizarro J.C."/>
                <person name="Wernimont A.K."/>
                <person name="Hutchinson A."/>
                <person name="Sullivan H."/>
                <person name="Lew J."/>
                <person name="Bochkarev A."/>
                <person name="Arrowsmith C.H."/>
                <person name="Bountra C."/>
                <person name="Weigelt J."/>
                <person name="Edwards A.M."/>
                <person name="Hui R."/>
                <person name="Hills T."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS) OF 15-396 IN COMPLEX WITH ADP</scope>
    </reference>
    <reference evidence="9" key="4">
        <citation type="submission" date="2009-12" db="PDB data bank">
            <title>Crystal structure of the N-terminal domain of HSP70 from Cryptosporidium parvum (CGD2_20).</title>
            <authorList>
                <consortium name="Structural Genomics Consortium (SGC)"/>
                <person name="Pizarro J.C."/>
                <person name="Wernimont A.K."/>
                <person name="Hutchinson A."/>
                <person name="Sullivan H."/>
                <person name="Lew J."/>
                <person name="Bochkarev A."/>
                <person name="Arrowsmith C.H."/>
                <person name="Bountra C."/>
                <person name="Weigelt J."/>
                <person name="Edwards A.M."/>
                <person name="Hui R."/>
                <person name="Hills T."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.29 ANGSTROMS) OF 15-396 IN COMPLEX WITH MG(2+)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625373.1">
        <property type="nucleotide sequence ID" value="XM_625373.1"/>
    </dbReference>
    <dbReference type="PDB" id="3KVG">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="A/B=15-396"/>
    </dbReference>
    <dbReference type="PDB" id="3L4I">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A/B=15-396"/>
    </dbReference>
    <dbReference type="PDB" id="3L6Q">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.29 A"/>
        <property type="chains" value="A/B=15-396"/>
    </dbReference>
    <dbReference type="PDBsum" id="3KVG"/>
    <dbReference type="PDBsum" id="3L4I"/>
    <dbReference type="PDBsum" id="3L6Q"/>
    <dbReference type="AlphaFoldDB" id="Q5CPP8"/>
    <dbReference type="SMR" id="Q5CPP8"/>
    <dbReference type="FunCoup" id="Q5CPP8">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPP8"/>
    <dbReference type="GeneID" id="3372348"/>
    <dbReference type="KEGG" id="cpv:cgd2_20"/>
    <dbReference type="InParanoid" id="Q5CPP8"/>
    <dbReference type="OMA" id="AYTKNQD"/>
    <dbReference type="OrthoDB" id="413580at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CPP8"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10233">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000172">
        <property type="entry name" value="Heat shock 70 kDa protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="7 8 9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1 3 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="657"/>
            <end position="682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="657"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="25"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="214"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="284"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="352"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="3KVG"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="3L4I"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="3L6Q"/>
        </source>
    </evidence>
    <sequence length="682" mass="74457" checksum="B9F5CE62B0948B7C" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPQ4</accession>
    <name>Q5CPQ4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Bifunctional dihydrofolate reductase-thymidylate synthase</fullName>
            <ecNumber evidence="5">1.5.1.3</ecNumber>
            <ecNumber evidence="4">2.1.1.45</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">cgd4_4460</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15009"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="1.5.1.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>dUMP + (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate = 7,8-dihydrofolate + dTMP</text>
            <dbReference type="Rhea" id="RHEA:12104"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:57451"/>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
            <dbReference type="ChEBI" id="CHEBI:246422"/>
            <dbReference type="EC" id="2.1.1.45"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-tetrahydrofolate from 7,8-dihydrofolate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the thymidylate synthase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the N-terminal section; belongs to the dihydrofolate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.5.1.3" evidence="5"/>
    <dbReference type="EC" id="2.1.1.45" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625460.1">
        <property type="nucleotide sequence ID" value="XM_625460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPQ4"/>
    <dbReference type="FunCoup" id="Q5CPQ4">
        <property type="interactions" value="26"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPQ4"/>
    <dbReference type="GeneID" id="3372431"/>
    <dbReference type="KEGG" id="cpv:cgd4_4460"/>
    <dbReference type="InParanoid" id="Q5CPQ4"/>
    <dbReference type="OMA" id="ILCAWNV"/>
    <dbReference type="OrthoDB" id="766at2759"/>
    <dbReference type="UniPathway" id="UPA00077">
        <property type="reaction ID" value="UER00158"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004146">
        <property type="term" value="F:dihydrofolate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004799">
        <property type="term" value="F:thymidylate synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006231">
        <property type="term" value="P:dTMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046654">
        <property type="term" value="P:tetrahydrofolate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00209">
        <property type="entry name" value="DHFR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00351">
        <property type="entry name" value="TS_Pyrimidine_HMase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.572.10:FF:000013">
        <property type="entry name" value="Thymidylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.430.10">
        <property type="entry name" value="Dihydrofolate Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.572.10">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00008">
        <property type="entry name" value="Thymidy_synth_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024072">
        <property type="entry name" value="DHFR-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012262">
        <property type="entry name" value="DHFR-TS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017925">
        <property type="entry name" value="DHFR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001796">
        <property type="entry name" value="DHFR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045097">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023451">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036926">
        <property type="entry name" value="Thymidate_synth/dCMP_Mease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000398">
        <property type="entry name" value="Thymidylate_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020940">
        <property type="entry name" value="Thymidylate_synthase_AS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002497">
        <property type="entry name" value="PRK01827.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03284">
        <property type="entry name" value="thym_sym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548:SF2">
        <property type="entry name" value="THYMIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11548">
        <property type="entry name" value="THYMIDYLATE SYNTHASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00186">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00303">
        <property type="entry name" value="Thymidylat_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000389">
        <property type="entry name" value="DHFR-TS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00108">
        <property type="entry name" value="THYMDSNTHASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53597">
        <property type="entry name" value="Dihydrofolate reductase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55831">
        <property type="entry name" value="Thymidylate synthase/dCMP hydroxymethylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00075">
        <property type="entry name" value="DHFR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51330">
        <property type="entry name" value="DHFR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00091">
        <property type="entry name" value="THYMIDYLATE_SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="11" id="KW-0521">NADP</keyword>
    <keyword evidence="10" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="7" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="12" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DHFR" evidence="19">
        <location>
            <begin position="15"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="active site" evidence="17 18">
        <location>
            <position position="412"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00019798"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00025154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00048873"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR000389-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EAK87446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="531" mass="61507" checksum="D8EE851E25F408E3" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ66</accession>
    <name>Q5CQ66_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein of the alpha beta hydrolase superfamily</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_3960</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625560.1">
        <property type="nucleotide sequence ID" value="XM_625560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ66"/>
    <dbReference type="ESTHER" id="crypv-q5cq66">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="3372602"/>
    <dbReference type="KEGG" id="cpv:cgd5_3960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3960"/>
    <dbReference type="InParanoid" id="Q5CQ66"/>
    <dbReference type="OMA" id="ACHLASY"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF28">
        <property type="entry name" value="AB HYDROLASE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254398" evidence="1">
        <location>
            <begin position="24"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="49"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="366" mass="42069" checksum="E70E63F533B3E697" modified="2005-04-12" version="1">MNLKYVITLICFITLCFYQGSSCVIKSDFADLKSGRTFYTITKEEQKKRIVMVHGLLAASTQFDNWRCIFSHTGYQVLTYDLLGHANTEWKLPGFFSQKRFVDQLNELLKHVGWVDSDNKAVEKISLLGVSMGGLIIINYALEHPDHISNLIPMCPPGIMTKYDFPKLYRLSNSSLVSAIKNIHNSKRVFRCGFYCASKLGYVKLGKQTKEEKKATTNVFHQMFSTYIKSGGDGNLFDRHLDFERLSKYENTFKIIFFWGMKDDVVPFPPALEFLVKHFSSTPIVVYPNIKHIPAYLMYSPALVTLDFLESNFTVGVPLGQVKELKYFYDNEVNIVTGLNFTISNEIIVKSNKENFTESYLDFMDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ86</accession>
    <name>Q5CQ86_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Dynactin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_3750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625540.1">
        <property type="nucleotide sequence ID" value="XM_625540.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ86"/>
    <dbReference type="FunCoup" id="Q5CQ86">
        <property type="interactions" value="216"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ86"/>
    <dbReference type="GeneID" id="3372556"/>
    <dbReference type="KEGG" id="cpv:cgd5_3750"/>
    <dbReference type="InParanoid" id="Q5CQ86"/>
    <dbReference type="OMA" id="IPPFTEW"/>
    <dbReference type="OrthoDB" id="417208at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047125">
        <property type="entry name" value="DCTN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46126:SF1">
        <property type="entry name" value="DYNACTIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21711">
        <property type="entry name" value="DCTN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="163"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="172"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="192"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00034706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="237" mass="25998" checksum="B96B5105DFF46837" modified="2005-04-12" version="1" fragment="single">ITNRGDLVMIRIGQYVILEQNCIVRPCFKKIKGKYGSVPISIGDCVQIGENSVVMASSIGSNVYIGKNSIIGSGSIIKDNCIILPDTTIAPNTLIPPFTEWGGTPGVMLRRLPESQNTLLQQSAIEYYNNFELVSNKVQEEPEKIQHSNTTLIKSMKTGITNFAKNKGDNGNGDDDDDDDDDDDDDDDDDNNNNNNNNNNNSNNDVNNNDRANDESREDGEGKEGEYGREGGESELS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQB1</accession>
    <name>Q5CQB1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_1410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625737.1">
        <property type="nucleotide sequence ID" value="XM_625737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQB1"/>
    <dbReference type="GeneID" id="3372638"/>
    <dbReference type="KEGG" id="cpv:cgd4_1410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1410"/>
    <dbReference type="InParanoid" id="Q5CQB1"/>
    <dbReference type="OrthoDB" id="343550at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="174"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="234" mass="27244" checksum="4F73BFBC949CC07F" modified="2005-04-12" version="1">MNKVSDYSTKEESQDLTKVKKEKSTKSGILKHVLLGSIIAVIFGCVSKYYFFDKIVLTEENLPNISSINQNEVNIGNKEKTLTKGTFGEEEYMELLQDDKTITLEQITQDDSLEDNDELMFNHEDEALYDQIEDDYRDDEAEDESEDGENESQIDSETLKRMLKEDVQLELDEGFAAKDFENEESIDVIDDAEIDEYEHETDDDITDNNWSDDETELKKMENQKEQEQKQEKQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQE9</accession>
    <name>Q5CQE9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625699.1">
        <property type="nucleotide sequence ID" value="XM_625699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQE9"/>
    <dbReference type="GeneID" id="3372686"/>
    <dbReference type="KEGG" id="cpv:cgd4_980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_980"/>
    <dbReference type="InParanoid" id="Q5CQE9"/>
    <dbReference type="OMA" id="IQWNTIT"/>
    <dbReference type="OrthoDB" id="342552at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="141"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="307"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="399" mass="45273" checksum="B1E8C8CA06B15577" modified="2005-04-12" version="1">MDFSPIKSQLDDSLFGHSSFFGLLLNTLLVLIYFVLGALSVFQSLSALESNTTENVFETNGIKIRPYFLSTFSIGIIFRLLYIIVYLAINILPKFIENGLINKLNILRMFDYLINIVFLASYSIVIALWSSIFTHSRSFEFTIITLLNFALYLTGGGIIVITLLITQKFPVLFNVLYILMGLLHLLFSYFWVHYGSSLFTQINRRQAMHKDLQKDLISKNANFTWNTNSNIINSGFNQVRGTNCLQYGMLNSGQVSIIQFNQDSSANTANTVNTASSSNNSNSSILSGLFIYNKAYSSSINKLRFKIQVLTLVCPISLLISSLYYLLRGFGIVNSNPEILLNTVWTALYTFFAETIPSIALIYGFWSSKNSFLGDTIDKSYNQHNNNVQDNFRCYTRIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQK2</accession>
    <name>Q5CQK2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein with 8 transmembrane domains, possible amino alcohol phosphotransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_390</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625646.1">
        <property type="nucleotide sequence ID" value="XM_625646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQK2"/>
    <dbReference type="STRING" id="353152.Q5CQK2"/>
    <dbReference type="GeneID" id="3372661"/>
    <dbReference type="KEGG" id="cpv:cgd4_390"/>
    <dbReference type="InParanoid" id="Q5CQK2"/>
    <dbReference type="OMA" id="CTAAWIT"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="88"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="190"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="227"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="308"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="335"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="367" mass="41893" checksum="72B85F2A30204F96" modified="2005-04-12" version="1" fragment="single">ENKVISVPIKMKETGVESKNVSGKHEEYKYVQPMTSPLYNNVISPVCDKIVGFLPKYLSPNLLTIIGLISISTSFIMLISIGENSKKLYFVSAALWFLYGIIDNLDGKQARRLGVSSNSGEFIDHAIDSVVTSFVGLAFQYMHNRYLELDLLVVLSYQLPFYFACWFHFKYGKLIIGNSVSKTPYFTVDELNLVFVPLFILFEYLFPGLWNLDIPLYGGYIIKSWGIPFNYCCFIYSIFTLLSCLHYCLSKSLTNAHLLFIPLTIHVTSKELAKLSMYNTILPFSILCITFIFLKISKLLIKKPTRSFITLIGASLIPNITTKLLVSVFEINQNLTIFIQFLIWALLVYEFANYLDSPCEDAEDKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQQ7</accession>
    <name>Q5CQQ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large glycine-rich repeat low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625945.1">
        <property type="nucleotide sequence ID" value="XM_625945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQQ7"/>
    <dbReference type="STRING" id="353152.Q5CQQ7"/>
    <dbReference type="GeneID" id="3372808"/>
    <dbReference type="KEGG" id="cpv:cgd4_3690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3690"/>
    <dbReference type="InParanoid" id="Q5CQQ7"/>
    <dbReference type="OMA" id="WIGYENG"/>
    <dbReference type="OrthoDB" id="10540356at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="453"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="575"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="329"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="376"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="459"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="481"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="552"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="575"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="607"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="634"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="655"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="677"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="694"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="720"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="763"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="804"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="821"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="842"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="937"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="957"/>
            <end position="966"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="967"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1002"/>
            <end position="1017"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1046"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1046" mass="106508" checksum="724DAAF299B41FB4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQQ8</accession>
    <name>Q5CQQ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87760.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625944.1">
        <property type="nucleotide sequence ID" value="XM_625944.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQQ8"/>
    <dbReference type="GeneID" id="3372807"/>
    <dbReference type="KEGG" id="cpv:cgd4_3680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3680"/>
    <dbReference type="InParanoid" id="Q5CQQ8"/>
    <dbReference type="OrthoDB" id="344143at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87760.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="286" mass="31936" checksum="B5E80D66CEF86DFB" modified="2005-04-12" version="1">MNFNKYFLLVVTIVVYINNLNFNNNGRLYTSIAHNDSIFVGIERNSRNYFLSSQSFLTLSLKSNAPSKKSGKKSSKNDSSNRGQGQNSQTFEETMDDLAKKLEKFSISSSSRKVIEVTCLDLISLLNVLTQGIQFLQTLITMISDFSLLESCLQALIARSVGKGSTLSKLLSSIRKVSKALESQKSMFKSLLKLLNESESKLGSISSLIQQCKMTVSQSLLLGYPRFEGYFSLPEKINGSQKKVTSFDSFFSKIVTEYCNDGFLASIDDEILKLQSKDIVEDMEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQY6</accession>
    <name>Q5CQY6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
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        <lineage>
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            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
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            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625866.1">
        <property type="nucleotide sequence ID" value="XM_625866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQY6"/>
    <dbReference type="GeneID" id="3373003"/>
    <dbReference type="KEGG" id="cpv:cgd4_2810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2810"/>
    <dbReference type="InParanoid" id="Q5CQY6"/>
    <dbReference type="OMA" id="INDALYM"/>
    <dbReference type="OrthoDB" id="340494at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254420" evidence="1">
        <location>
            <begin position="22"/>
            <end position="1083"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1083" mass="126124" checksum="91C767D2BCE2E820" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRB8</accession>
    <name>Q5CRB8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88037.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626268.1">
        <property type="nucleotide sequence ID" value="XM_626268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRB8"/>
    <dbReference type="GeneID" id="3373057"/>
    <dbReference type="KEGG" id="cpv:cgd5_3440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3440"/>
    <dbReference type="InParanoid" id="Q5CRB8"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88037.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="103" mass="12243" checksum="2C9C875A03B5536B" modified="2005-04-12" version="1">MSKLPLIDLYLKIIFNSFNLKQFYMPCSLSLMEYFDPYFFSLLLLLDVICTKYVYVQIATYNSNKYLINSLYFHITVGGSLFVSFTQFPKDLDENYNFFLSLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRN0</accession>
    <name>Q5CRN0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large low complexity protein with proline/alanine-rich repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626156.1">
        <property type="nucleotide sequence ID" value="XM_626156.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRN0"/>
    <dbReference type="GeneID" id="3373111"/>
    <dbReference type="KEGG" id="cpv:cgd5_2180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2180"/>
    <dbReference type="InParanoid" id="Q5CRN0"/>
    <dbReference type="OMA" id="LRFDWQE"/>
    <dbReference type="OrthoDB" id="344311at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="248"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="109"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="248"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="259"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="358"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="394"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="461"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="503"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="538"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="560"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="591"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="638"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="686"/>
            <end position="699"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="733"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="768"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="790"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="814"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="858"/>
            <end position="871"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="880"/>
            <end position="894"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="919"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1006"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1039"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1065"/>
            <end position="1077"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1079"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1123"/>
            <end position="1137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1154"/>
            <end position="1167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1212"/>
            <end position="1256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1273"/>
            <end position="1287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1296"/>
            <end position="1361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1376"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1391"/>
            <end position="1402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1409"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1422"/>
            <end position="1446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1463"/>
            <end position="1497"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1514"/>
            <end position="1538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1539"/>
            <end position="1550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1575"/>
            <end position="1589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1610" mass="162271" checksum="2DBC2CD0FFF6AE4A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRR2</accession>
    <name>Q5CRR2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_1800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_626124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRR2"/>
    <dbReference type="GeneID" id="3373006"/>
    <dbReference type="KEGG" id="cpv:cgd5_1800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1800"/>
    <dbReference type="InParanoid" id="Q5CRR2"/>
    <dbReference type="OMA" id="EDENCHQ"/>
    <dbReference type="OrthoDB" id="338268at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="710" mass="81252" checksum="95F911EA0F99ACD6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRS5</accession>
    <name>Q5CRS5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="1" type="ORF">cgd5_1670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
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            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_626111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRS5"/>
    <dbReference type="GeneID" id="3373015"/>
    <dbReference type="KEGG" id="cpv:cgd5_1670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1670"/>
    <dbReference type="InParanoid" id="Q5CRS5"/>
    <dbReference type="OMA" id="NAPYHMA"/>
    <dbReference type="OrthoDB" id="336297at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="157" mass="16800" checksum="8FB339734AA57DC8" modified="2005-04-12" version="1">MDSGQPSVPTIPASSSILPVSGAPSIPTLYAQPKTFVPVDCRVMPGYPFASLAGVPCVIPPLPEDFVTQKSDKEGPQNTQNLPEPHRFHNGQPLNPYISPTDQTVIVNAPYHLAQFNPVSGSSMYSPCNPFVAYPYGIPARGPTPGSQPKKTGFYAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRT3</accession>
    <name>Q5CRT3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626103.1">
        <property type="nucleotide sequence ID" value="XM_626103.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRT3"/>
    <dbReference type="GeneID" id="3373020"/>
    <dbReference type="KEGG" id="cpv:cgd5_1560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1560"/>
    <dbReference type="InParanoid" id="Q5CRT3"/>
    <dbReference type="OMA" id="TLNWINS"/>
    <dbReference type="OrthoDB" id="343897at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="201"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="227" mass="26908" checksum="103F9FA3DC3F3243" modified="2005-04-12" version="1">MDVNPSTNSVEAGRCLDLLVNQLISSQYWQGTVRSHQIRNCVSLFNRYLRLSNQQDLRILTQEIRDRVANDTIYNEFLSQLDTECISYHSFWQTYKEKFVKIFKKLSNFHLIILDHAKILETKVFNLLPNFLKNSIIPSYRRPLIFIYLLNVILFILRLTAFNSKPIFHNYTKIGRYSANNNINIMDDYNYPTFLEIVYEVLMFFLNILTSIIPLALPIITLHFINR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRT6</accession>
    <name>Q5CRT6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626100.1">
        <property type="nucleotide sequence ID" value="XM_626100.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRT6"/>
    <dbReference type="GeneID" id="3373022"/>
    <dbReference type="KEGG" id="cpv:cgd5_1530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1530"/>
    <dbReference type="InParanoid" id="Q5CRT6"/>
    <dbReference type="OrthoDB" id="343611at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254307" evidence="1">
        <location>
            <begin position="19"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="243" mass="27435" checksum="7B2B2389D99AA8C8" modified="2005-04-12" version="1">MKLLLSSIFLILCVFTSGTPIPTPNEIVLAINSNVKYKYPNIEVPLDWQSRVFIKYYPEESSIKVHCPVENDAPFGRTLIRNLFRIYKRNFPSDKRIKKMKLSFQSPSGEFITAEKLSTKGYLSALNELVEDLIEEDIENVVASASSPTLPNTKLSISSLSSLSDSNVQNYPVYVFFTNEEERLKQEGMVQLLVQLGFNVAHTFGNATCNVDSTNYSVKIPEILSPTIDKNINTTFVEENPNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRV4</accession>
    <name>Q5CRV4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein NO VEIN C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626082.1">
        <property type="nucleotide sequence ID" value="XM_626082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRV4"/>
    <dbReference type="STRING" id="353152.Q5CRV4"/>
    <dbReference type="GeneID" id="3373292"/>
    <dbReference type="KEGG" id="cpv:cgd5_1350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1350"/>
    <dbReference type="InParanoid" id="Q5CRV4"/>
    <dbReference type="OrthoDB" id="913285at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052957">
        <property type="entry name" value="Auxin_embryo_med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024975">
        <property type="entry name" value="NOV_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387:SF0">
        <property type="entry name" value="PROTEIN NO VEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387">
        <property type="entry name" value="WU:FJ29H11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13020">
        <property type="entry name" value="NOV_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein NO VEIN C-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="131" mass="15521" checksum="78D4A64473C19954" modified="2005-04-12" version="1">MGEKLAFDSLKEKFSNELGIDYFNITWVNETAESGLPYDIILVFMDKTRGTKEEIFVEVKSSSKKEKNFFRISFNEWKLAERLQNNYWLFHILGVNLNAPNLSLNDIEFRIIRNPYESWKDGRLKMILSEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRW9</accession>
    <name>Q5CRW9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">CPSF metallobeta-lactamase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd5_1170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626067.1">
        <property type="nucleotide sequence ID" value="XM_626067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRW9"/>
    <dbReference type="FunCoup" id="Q5CRW9">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRW9"/>
    <dbReference type="GeneID" id="3373097"/>
    <dbReference type="KEGG" id="cpv:cgd5_1170"/>
    <dbReference type="InParanoid" id="Q5CRW9"/>
    <dbReference type="OMA" id="DCGAHCG"/>
    <dbReference type="OrthoDB" id="10249535at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016180">
        <property type="term" value="P:snRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16291">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10890:FF:000002">
        <property type="entry name" value="Integrator complex subunit 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041897">
        <property type="entry name" value="INTS11-like_MBL-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050698">
        <property type="entry name" value="MBL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011108">
        <property type="entry name" value="RMMBL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11203:SF37">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10996">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16661">
        <property type="entry name" value="Lactamase_B_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07521">
        <property type="entry name" value="RMMBL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00849">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="10">
        <location>
            <begin position="17"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="Beta-Casp" evidence="11">
        <location>
            <begin position="266"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007093"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="751" mass="85870" checksum="2219A1D2F4B3740E" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS62</accession>
    <name>Q5CS62_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_90</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625974.1">
        <property type="nucleotide sequence ID" value="XM_625974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS62"/>
    <dbReference type="GeneID" id="3373335"/>
    <dbReference type="KEGG" id="cpv:cgd5_90"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_90"/>
    <dbReference type="InParanoid" id="Q5CS62"/>
    <dbReference type="OMA" id="NFWDSEL"/>
    <dbReference type="OrthoDB" id="343841at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="91"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="566"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="267"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="595" mass="65575" checksum="3762EF166603695A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS84</accession>
    <name>Q5CS84_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 1</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">GPI mannosyltransferase I</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd1_3720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalytic subunit of the glycosylphosphatidylinositol-mannosyltransferase I complex which catalyzes the transfer of the first mannose, via an alpha-1,4 bond from a dolichol-phosphate-mannose (Dol-P-Man) to the glucosaminyl acyl phosphatidylinositol (GlcN-(acyl)PI) intermediate to generate alpha-D-Man-(1-&gt;4)-alpha-D-GlcN-(1-&gt;6)-(1-radyl,2-acyl-sn-glycero-3-phospho)-2-acyl-inositol and participates in the sixth step of the glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628183.1">
        <property type="nucleotide sequence ID" value="XM_628183.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS84"/>
    <dbReference type="FunCoup" id="Q5CS84">
        <property type="interactions" value="336"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS84"/>
    <dbReference type="GeneID" id="3371481"/>
    <dbReference type="KEGG" id="cpv:cgd1_3720"/>
    <dbReference type="InParanoid" id="Q5CS84"/>
    <dbReference type="OMA" id="MLWFIGQ"/>
    <dbReference type="OrthoDB" id="1741594at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990529">
        <property type="term" value="C:glycosylphosphatidylinositol-mannosyltransferase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051751">
        <property type="term" value="F:alpha-1,4-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007704">
        <property type="entry name" value="PIG-M"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886:SF0">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12886">
        <property type="entry name" value="PIG-M MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05007">
        <property type="entry name" value="Mannosyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11 12" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="135"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="298"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="374"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="420" mass="48844" checksum="99776BE32ACC4BC7" modified="2005-04-12" version="1" fragment="single">YVVEHVYLSTTCLHLLVLSYGLLQDRFNVSVKFTDIDYMVFTDAAKAVLQGKSPYTRHTYRYTPLLAYIASINIIFKMEILSKLLFCAVNILSGKILEWLLILLDVDNETKIKGSVTLRRFLISTWLLNPFPVVIAARGSADIIPSILVLITIYFLMKAKYDSFNNKINIIISAFFFGLSVHFKLYPVIYGFPFIFFINPNYLKKDRSLFWYILNLPIKIFTTLNIDQLIFGLVSFSTIVSLISFFYYLYGWEFLYETYLYHAIRKDHRHNFSVFFYLFYLTMYSVKEVLASNFVYKALPYIASIPQMFLVALSGISLVREGECIMAIFCQTVLFVAFNKVCTSQYFLWWFILFPLALRVYLTNNIAQLDESKGIIHSASASFTPILISLGVWLITKLSWLYFAYNIEMLGQPYFLSVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS87</accession>
    <name>Q5CS87_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extracellular membrane associated protein with 3 EGF domains and a transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_3680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628180.1">
        <property type="nucleotide sequence ID" value="XM_628180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS87"/>
    <dbReference type="STRING" id="353152.Q5CS87"/>
    <dbReference type="GeneID" id="3371445"/>
    <dbReference type="KEGG" id="cpv:cgd1_3680"/>
    <dbReference type="InParanoid" id="Q5CS87"/>
    <dbReference type="OMA" id="FLCCCNV"/>
    <dbReference type="OrthoDB" id="430340at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009986">
        <property type="term" value="C:cell surface"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000118">
        <property type="entry name" value="protein delta homolog 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050906">
        <property type="entry name" value="Notch_signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010423">
        <property type="entry name" value="Pvs25/Psv28_EGF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044">
        <property type="entry name" value="NOTCH LIGAND FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24044:SF417">
        <property type="entry name" value="WEARY, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06247">
        <property type="entry name" value="Plasmod_Pvs28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 3" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="216"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="47"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="113"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="157"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="247"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="81"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="126"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="145"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="167"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="3">
        <location>
            <begin position="186"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="268" mass="29497" checksum="426CB13B53118DE5" modified="2005-04-12" version="1" fragment="single">CYIINMLLPNENNSKEINNNSHISTTPNDNLIIKVSNQLRNLQNLPFESICAGDQTINCGENGKCISLPNVNNQKQFLCVCSDGFTGPSCKTGKFIDQLFILSFNLKKKLNLAWDACLTSGPTSLCLNGGICTSKDTPPYYECKCTVGFTGINCEVENNVCKTNNPCQNGGKCSYIGENLPIICTCLTGYSGDYCQIIVKHGIGGAGVKLHPGQIIMIWGFLLFILATILYCTFSVVYDIIVQIRAKKRKDQQEKDDDMDSPSQSDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS98</accession>
    <name>Q5CS98_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Myosin regulatory light chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628169.1">
        <property type="nucleotide sequence ID" value="XM_628169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS98"/>
    <dbReference type="GeneID" id="3371572"/>
    <dbReference type="KEGG" id="cpv:cgd1_3570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3570"/>
    <dbReference type="InParanoid" id="Q5CS98"/>
    <dbReference type="OMA" id="MNESTDK"/>
    <dbReference type="OrthoDB" id="435273at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="238"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="248"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="267" mass="30146" checksum="64A73933D0A0FB22" modified="2005-04-12" version="1">MEIINRTLDSIFVKCHDIQVENIKYGELVVLIESDDDYSGYSDADINENYGEFDGENEDNGEIANESSVEDVLEIVRQATIAKKEPTIYEIEFGNVSNTSGKCNFDDLIKFLHRLGLSPTEDQCNELKKEFGTSNIDMESALKAYNKTSTDKYTPEELIVSLESTQSEVTRKRLVILLQTFGDKMTEDEINRALDKLEIGNEPIDKNLFIEKLCAGSKQIKTSNTGCINTQSRENLNKSSENCIDPQDNNNNNNDNNVQQEEISDVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSH2</accession>
    <name>Q5CSH2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628095.1">
        <property type="nucleotide sequence ID" value="XM_628095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSH2"/>
    <dbReference type="GeneID" id="3371687"/>
    <dbReference type="KEGG" id="cpv:cgd1_2720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2720"/>
    <dbReference type="InParanoid" id="Q5CSH2"/>
    <dbReference type="OMA" id="ANTICEY"/>
    <dbReference type="OrthoDB" id="338402at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="545"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="760" mass="86387" checksum="913E5C367B0977F2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSN0</accession>
    <name>Q5CSN0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical low complexity coiled coil</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_2010</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628037.1">
        <property type="nucleotide sequence ID" value="XM_628037.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSN0"/>
    <dbReference type="GeneID" id="3371653"/>
    <dbReference type="KEGG" id="cpv:cgd1_2010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2010"/>
    <dbReference type="InParanoid" id="Q5CSN0"/>
    <dbReference type="OMA" id="NDNCNTH"/>
    <dbReference type="OrthoDB" id="342021at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="75"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="632" mass="72110" checksum="A81BF1A13FA9CA21" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSU8</accession>
    <name>Q5CSU8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted secreted protein, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Iowa type II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627969.1">
        <property type="nucleotide sequence ID" value="XM_627969.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3371594"/>
    <dbReference type="KEGG" id="cpv:cgd1_1250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1250"/>
    <dbReference type="InParanoid" id="Q5CSU8"/>
    <dbReference type="OMA" id="RERDINM"/>
    <dbReference type="OrthoDB" id="338781at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="75"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="130"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="285"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1963"/>
            <end position="1993"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2057"/>
            <end position="2111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2358"/>
            <end position="2402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="190"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1979"/>
            <end position="1990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2069"/>
            <end position="2079"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2080"/>
            <end position="2089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2443" mass="277750" checksum="B3ED8225212ED414" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT10</accession>
    <name>Q5CT10_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627907.1">
        <property type="nucleotide sequence ID" value="XM_627907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT10"/>
    <dbReference type="GeneID" id="3371414"/>
    <dbReference type="KEGG" id="cpv:cgd1_490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_490"/>
    <dbReference type="InParanoid" id="Q5CT10"/>
    <dbReference type="OrthoDB" id="341526at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="130" mass="15128" checksum="DD1BF66F408C0F8B" modified="2005-04-12" version="1">MSEFVLVGSSLFEEKLMEFFNEGVKSKKINKMNALIMKIQKHEFDLSGKFQESDSNGKELLVPKCEIEQKIEIPLDQILATERNSFGVVSTGELFENICQFLRSDDKIRDYKDDFRIILINGAYFSKYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT22</accession>
    <name>Q5CT22_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CG8205/fusilli (Animal)-like, 2x RRM domains, involved in RNA metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627895.1">
        <property type="nucleotide sequence ID" value="XM_627895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT22"/>
    <dbReference type="STRING" id="353152.Q5CT22"/>
    <dbReference type="GeneID" id="3371419"/>
    <dbReference type="KEGG" id="cpv:cgd1_350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_350"/>
    <dbReference type="InParanoid" id="Q5CT22"/>
    <dbReference type="OMA" id="KFATHED"/>
    <dbReference type="OrthoDB" id="431068at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12254">
        <property type="entry name" value="RRM_hnRNPH_ESRPs_RBM12_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050666">
        <property type="entry name" value="ESRP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13976">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="317"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="431"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="569" mass="64565" checksum="B04E185FEAE817ED" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT64</accession>
    <name>Q5CT64_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_4260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626605.1">
        <property type="nucleotide sequence ID" value="XM_626605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT64"/>
    <dbReference type="FunCoup" id="Q5CT64">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT64"/>
    <dbReference type="GeneID" id="3373688"/>
    <dbReference type="KEGG" id="cpv:cgd2_4260"/>
    <dbReference type="InParanoid" id="Q5CT64"/>
    <dbReference type="OMA" id="YVITHEK"/>
    <dbReference type="OrthoDB" id="10260596at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2650">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001377">
        <property type="entry name" value="Ribosomal_eS6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014401">
        <property type="entry name" value="Ribosomal_eS6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018282">
        <property type="entry name" value="Ribosomal_eS6_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11502">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01092">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002129">
        <property type="entry name" value="Ribosom_S6_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01405">
        <property type="entry name" value="Ribosomal_S6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00578">
        <property type="entry name" value="RIBOSOMAL_S6E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="195"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="225" mass="25963" checksum="73DC6A34A106CF49" modified="2005-04-12" version="1" fragment="single">AVPKMKLNIANPTTGLQKCIEIDDEKLLLPFFERRIGSELDCSFLGEEFKGYILKITGGNDKQGFPMMQGVLTSNRVRLLFRKGMKCYRPRRTGEMKRKSVRGCIVSHDLSVLSLVVVERGEQDIPGLTDGEKPRRLGPKRASKIRKLFNLSPSDDVRKFVVRRKIEGKEKTKAPKIQRLVTKERLQRKKKYRRTLKERSEASANAKKEYQKLLETLKENKTNTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT73</accession>
    <name>Q5CT73_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="17">Transmembrane protein 230</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">cgd2_4170</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">Involved in trafficking and recycling of synaptic vesicles.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasmic vesicle</location>
            <location evidence="5">Autophagosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasmic vesicle</location>
            <location evidence="3">Secretory vesicle</location>
            <location evidence="3">Synaptic vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Early endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Golgi apparatus</location>
            <location evidence="6">trans-Golgi network</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Late endosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Recycling endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TMEM134/TMEM230 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626596.1">
        <property type="nucleotide sequence ID" value="XM_626596.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT73"/>
    <dbReference type="GeneID" id="3373477"/>
    <dbReference type="KEGG" id="cpv:cgd2_4170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4170"/>
    <dbReference type="InParanoid" id="Q5CT73"/>
    <dbReference type="OMA" id="DAPQFAM"/>
    <dbReference type="OrthoDB" id="342763at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005776">
        <property type="term" value="C:autophagosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055037">
        <property type="term" value="C:recycling endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044234">
        <property type="entry name" value="TMEM230"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008590">
        <property type="entry name" value="TMEM_230/134"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664">
        <property type="entry name" value="C20ORF30 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15664:SF6">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 230"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05915">
        <property type="entry name" value="TMEM_230_134"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="10" id="KW-0967">Endosome</keyword>
    <keyword evidence="13" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0770">Synapse</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="51"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="84"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004412"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00004603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00007743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00024003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00024088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EAK88616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="119" mass="13435" checksum="5B395F41A9A04B9A" modified="2005-04-12" version="1">MEISQRKHFEVDKHEKARKEAHNGPSLSQKKVGFLSPKSFKTKSGLPLKPIFLSFFLFIVGSFFFYIGLALFLSKKYSDSTPSLLLGILCIIPGSYYSFSILQILRGVSGYSFEQLDIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTB8</accession>
    <name>Q5CTB8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626551.1">
        <property type="nucleotide sequence ID" value="XM_626551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTB8"/>
    <dbReference type="STRING" id="353152.Q5CTB8"/>
    <dbReference type="GeneID" id="3373620"/>
    <dbReference type="KEGG" id="cpv:cgd2_3640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3640"/>
    <dbReference type="InParanoid" id="Q5CTB8"/>
    <dbReference type="OMA" id="TISSYMQ"/>
    <dbReference type="OrthoDB" id="343702at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="318"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="490"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="520"/>
            <end position="536"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="553" mass="61125" checksum="BB452C766358B73A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTT9</accession>
    <name>Q5CTT9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-tyrosine-phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_1580</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.48" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626380.1">
        <property type="nucleotide sequence ID" value="XM_626380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTT9"/>
    <dbReference type="STRING" id="353152.Q5CTT9"/>
    <dbReference type="GeneID" id="3373715"/>
    <dbReference type="KEGG" id="cpv:cgd2_1580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1580"/>
    <dbReference type="InParanoid" id="Q5CTT9"/>
    <dbReference type="OMA" id="WSGRACT"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004725">
        <property type="term" value="F:protein tyrosine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008138">
        <property type="term" value="F:protein tyrosine/serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848:SF4">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45848">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN PHOSPHATASE 12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="121" mass="14233" checksum="00243372C89F12B5" modified="2005-04-12" version="1">MPNKYVFRCKKCGSTLFTTDHIIKHGKLNERNEEFNLKDENNLCTSYFISNTSWMEDYTEQNGRITCPNRSCDSKLGYYCWFGGKCSCGYWQTPSFQIHKSKVDYLPDSLRRNTIDITIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU28</accession>
    <name>Q5CU28_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626291.1">
        <property type="nucleotide sequence ID" value="XM_626291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU28"/>
    <dbReference type="STRING" id="353152.Q5CU28"/>
    <dbReference type="GeneID" id="3373390"/>
    <dbReference type="KEGG" id="cpv:cgd2_540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_540"/>
    <dbReference type="InParanoid" id="Q5CU28"/>
    <dbReference type="OrthoDB" id="342746at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005178">
        <property type="entry name" value="Ostalpha/TMEM184C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03619">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01417">
        <property type="entry name" value="Solute_trans_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="330"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="419"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="449"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="524"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="28"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="97"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="155"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="5">
        <location>
            <begin position="174"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="210"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="572" mass="62198" checksum="5CE3A1BB3E12CB15" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU73</accession>
    <name>Q5CU73_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Yer007c-ap/MCT-1 like PUA RNA binding domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_3970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 3">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626941.1">
        <property type="nucleotide sequence ID" value="XM_626941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU73"/>
    <dbReference type="FunCoup" id="Q5CU73">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU73"/>
    <dbReference type="GeneID" id="3373845"/>
    <dbReference type="KEGG" id="cpv:cgd3_3970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3970"/>
    <dbReference type="InParanoid" id="Q5CU73"/>
    <dbReference type="OMA" id="GVENIHY"/>
    <dbReference type="OrthoDB" id="10249667at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11609">
        <property type="entry name" value="MCT1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21155">
        <property type="entry name" value="PUA_MCTS-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.400.20:FF:000001">
        <property type="entry name" value="Malignant T-cell-amplified sequence 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016437">
        <property type="entry name" value="MCT-1/Tma20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041366">
        <property type="entry name" value="Pre-PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798:SF0">
        <property type="entry name" value="MALIGNANT T-CELL-AMPLIFIED SEQUENCE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22798">
        <property type="entry name" value="MCT-1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17832">
        <property type="entry name" value="Pre-PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005067">
        <property type="entry name" value="Tma_RNA-bind_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="92"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR005067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="179" mass="20184" checksum="11614F21AAB79097" modified="2005-04-12" version="1">MLKKFSTENISSQNQVKSSVQRSIKANILALYPLLEQVIDDILPKKENIILSKCSGHFQFIVLDSIPLFFQQRDGPWFPTLRLLHKYPDMMPTMQVDKGAIKHVLKGSNIMCPGLTSPGGRMEQVEQKQVVKIVGEGCQNACAIGITTMSTDEIRQINKGVCIENVHYLNDGLWNVHKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUH8</accession>
    <name>Q5CUH8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_2780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NELF-D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626836.1">
        <property type="nucleotide sequence ID" value="XM_626836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUH8"/>
    <dbReference type="FunCoup" id="Q5CUH8">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUH8"/>
    <dbReference type="GeneID" id="3373960"/>
    <dbReference type="KEGG" id="cpv:cgd3_2780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2780"/>
    <dbReference type="InParanoid" id="Q5CUH8"/>
    <dbReference type="OMA" id="WNPPELY"/>
    <dbReference type="OrthoDB" id="364993at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032021">
        <property type="term" value="C:NELF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034244">
        <property type="term" value="P:negative regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006942">
        <property type="entry name" value="TH1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144:SF0">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR C_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12144">
        <property type="entry name" value="NEGATIVE ELONGATION FACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04858">
        <property type="entry name" value="TH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0678">Repressor</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="928"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1096" mass="125076" checksum="235EB0932B86CBCF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUJ2</accession>
    <name>Q5CUJ2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="16">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">cgd3_2620</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="16">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15 16">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 16">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="16"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626822.1">
        <property type="nucleotide sequence ID" value="XM_626822.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CUJ2">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUJ2"/>
    <dbReference type="GeneID" id="3373777"/>
    <dbReference type="KEGG" id="cpv:cgd3_2620"/>
    <dbReference type="InParanoid" id="Q5CUJ2"/>
    <dbReference type="OMA" id="KPCMGIV"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02584">
        <property type="entry name" value="RNAP_II_Rpb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02733">
        <property type="entry name" value="RNAP_II_RPB1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22541">
        <property type="entry name" value="SP5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.132.30:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.860.120:FF:000003">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000684">
        <property type="entry name" value="RNA_pol_II_repeat_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007075">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007073">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038593">
        <property type="entry name" value="RNA_pol_Rpb1_7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF37">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04992">
        <property type="entry name" value="RNA_pol_Rpb1_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04990">
        <property type="entry name" value="RNA_pol_Rpb1_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05001">
        <property type="entry name" value="RNA_pol_Rpb1_R"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00115">
        <property type="entry name" value="RNA_POL_II_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 16 19" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0677">Repeat</keyword>
    <keyword evidence="13 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="6 16" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="18">
        <location>
            <begin position="234"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1657"/>
            <end position="1880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1657"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="1683"/>
            <end position="1864"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAK89262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1902" mass="213171" checksum="DE0ED93F88897DA0" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUL4</accession>
    <name>Q5CUL4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Putative nucleoporin, FG-rich motifs within N-terminal region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd3_2360</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nucleoporin GLFG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89079.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626800.1">
        <property type="nucleotide sequence ID" value="XM_626800.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUL4"/>
    <dbReference type="GeneID" id="3373919"/>
    <dbReference type="KEGG" id="cpv:cgd3_2360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2360"/>
    <dbReference type="InParanoid" id="Q5CUL4"/>
    <dbReference type="OMA" id="VETTICF"/>
    <dbReference type="OrthoDB" id="448516at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008139">
        <property type="term" value="F:nuclear localization sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017056">
        <property type="term" value="F:structural constituent of nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000973">
        <property type="term" value="P:post-transcriptional tethering of RNA polymerase II gene DNA at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006405">
        <property type="term" value="P:RNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034398">
        <property type="term" value="P:telomere tethering at nuclear periphery"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1610.10">
        <property type="entry name" value="Peptidase S59, nucleoporin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037665">
        <property type="entry name" value="Nucleoporin_S59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007230">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036903">
        <property type="entry name" value="Nup98_auto-Pept-S59_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021967">
        <property type="entry name" value="Nup98_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198:SF6">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN NUP98-NUP96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23198">
        <property type="entry name" value="NUCLEOPORIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04096">
        <property type="entry name" value="Nucleoporin2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12110">
        <property type="entry name" value="Nup96"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82215">
        <property type="entry name" value="C-terminal autoproteolytic domain of nucleoporin nup98"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51434">
        <property type="entry name" value="NUP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0068">Autocatalytic cleavage</keyword>
    <keyword evidence="5" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="8" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase S59" evidence="11">
        <location>
            <begin position="906"/>
            <end position="1046"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="291"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="514"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="771"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="107"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="155"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="311"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022813"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89079.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1805" mass="198089" checksum="28CA8480F4E2584F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUN1</accession>
    <name>Q5CUN1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase</fullName>
            <ecNumber evidence="4">4.2.1.134</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd3_2150</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a very-long-chain (3R)-3-hydroxyacyl-CoA = a very-long-chain (2E)-enoyl-CoA + H2O</text>
            <dbReference type="Rhea" id="RHEA:45812"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:83728"/>
            <dbReference type="ChEBI" id="CHEBI:85440"/>
            <dbReference type="EC" id="4.2.1.134"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; fatty acid biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the very long-chain fatty acids dehydratase HACD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.134" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626783.1">
        <property type="nucleotide sequence ID" value="XM_626783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUN1"/>
    <dbReference type="FunCoup" id="Q5CUN1">
        <property type="interactions" value="100"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUN1"/>
    <dbReference type="GeneID" id="3374037"/>
    <dbReference type="KEGG" id="cpv:cgd3_2150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2150"/>
    <dbReference type="InParanoid" id="Q5CUN1"/>
    <dbReference type="OMA" id="WSYILWQ"/>
    <dbReference type="OrthoDB" id="46988at2759"/>
    <dbReference type="UniPathway" id="UPA00094"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102158">
        <property type="term" value="F:very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030497">
        <property type="term" value="P:fatty acid elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030148">
        <property type="term" value="P:sphingolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042761">
        <property type="term" value="P:very long-chain fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007482">
        <property type="entry name" value="Tyr_Pase-like_PTPLA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11035:SF3">
        <property type="entry name" value="VERY-LONG-CHAIN (3R)-3-HYDROXYACYL-COA DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04387">
        <property type="entry name" value="PTPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="5" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="9" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0456">Lyase</keyword>
    <keyword evidence="10 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14 15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="201"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00036671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK89088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="247" mass="28631" checksum="5051739F85ABFF80" modified="2005-04-12" version="1">MHSSKLKSIYLIIYGIVSTLFWATTLYFTINEIIGIKSTYEQLGKHMIALRISQSLAVLDIMNSSLGIVKSQFLPTIIQVSSRLHIVWIVFYLSPENSRQISTVFSNIMIITWSLSELIRYPYYVILQCSFNFPSIRMPLFLKWLRYSAFAVLYPIGIFSEVIICSNFISDIYNNSSSSDPVYQRLLHFPTKMPNALNFEVNLACLYIVILCIYIPGSIFMYSYMIRQRKKSLINLWKSEGDNTKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUT1</accession>
    <name>Q5CUT1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626733.1">
        <property type="nucleotide sequence ID" value="XM_626733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUT1"/>
    <dbReference type="GeneID" id="3374022"/>
    <dbReference type="KEGG" id="cpv:cgd3_1600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1600"/>
    <dbReference type="InParanoid" id="Q5CUT1"/>
    <dbReference type="OrthoDB" id="343964at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="132"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="213"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="396"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="400"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="425" mass="47650" checksum="19D62EA5046D9BDB" modified="2005-04-12" version="1">MSSVKDKCNNMPKQNHNESKISIIPNTAPYKFMRGLMCFLTVSLSMLYLIFSCSFAIKYRPLVFDNILTETIKGTIKGSNGEYIQWIATIPTGLVSRTVAIICVVMFLIFGVYTMLFSFYTACKKYKFIQPWHFMLLSAMSCVGGLISIFLSNKFAVVEEFTHKKDCLLQSVVSNDCSVAIGNNEIYAYDICKAVESFCLDENASMSRYYTKAIIVAVVSFIVSVLSFAYGIVLLNLKMRYSKKLALINEKNAISEKTKSDLEMSNSSSICQYDKDNSGINCQNNQSGTGYSTTDNTNVVNSTKTNVYYPNMSNDSCKAIQPYQNEMRSIPMGIVVTTTTSKQCHIAAHRNANSQVNTSNMGNIIGNSAISCVNSIHHSCHSGNLNHNRNAHHGLSLQQQHHHHHHHHHHHGPNHGNRQHHNQFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUV0</accession>
    <name>Q5CUV0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626714.1">
        <property type="nucleotide sequence ID" value="XM_626714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUV0"/>
    <dbReference type="GeneID" id="3373980"/>
    <dbReference type="KEGG" id="cpv:cgd3_1390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1390"/>
    <dbReference type="InParanoid" id="Q5CUV0"/>
    <dbReference type="OMA" id="FEWIDIC"/>
    <dbReference type="OrthoDB" id="341958at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010490">
        <property type="entry name" value="COG6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506">
        <property type="entry name" value="COMPONENT OF OLIGOMERIC GOLGI COMPLEX 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21506:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="686"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="686"/>
            <end position="712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="802" mass="91578" checksum="E471A28ED5CFDD97" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUZ2</accession>
    <name>Q5CUZ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626672.1">
        <property type="nucleotide sequence ID" value="XM_626672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUZ2"/>
    <dbReference type="GeneID" id="3374181"/>
    <dbReference type="KEGG" id="cpv:cgd3_910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_910"/>
    <dbReference type="InParanoid" id="Q5CUZ2"/>
    <dbReference type="OMA" id="CHRIHIR"/>
    <dbReference type="OrthoDB" id="335778at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="278" mass="32623" checksum="269FC43E356422CF" modified="2005-04-12" version="1">MTGSELRTPVSGCQWLGYNRVHIRESRTYKVSPKKKVEFMRYEYNSTSGCELENYSRQIIGYGDWDVNKYTRGNQTLVDVRINWRKVIIRSRMNHVNILDDLNKINWLYKSLSPVYFYDLNLLNTCIEHLTIVPDYDISAIDSKTIKIDGETIKISNEKLNIDHIPDSKVEEALLRMVTGYSGNVISDMVKKEFSIEKDWEEFFKHKSPRMRKICQWKDIKEFCLMPPSEIIHKHSCKLPSVDHLISSDLETLKVALYPYNSTLPDTDLIEFSKYKTC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV38</accession>
    <name>Q5CV38_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative ABC transporter, 12x transmembrane domains plus 2x AAA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd3_410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626626.1">
        <property type="nucleotide sequence ID" value="XM_626626.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV38"/>
    <dbReference type="GeneID" id="3373995"/>
    <dbReference type="KEGG" id="cpv:cgd3_410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_410"/>
    <dbReference type="InParanoid" id="Q5CV38"/>
    <dbReference type="OMA" id="NCITEEL"/>
    <dbReference type="OrthoDB" id="4865934at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="410"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="992"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1058"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1134"/>
            <end position="1155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1161"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1249"/>
            <end position="1268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1274"/>
            <end position="1299"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="297"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="600"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="1004"/>
            <end position="1314"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1364"/>
            <end position="1647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="254"/>
            <end position="275"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK89221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1651" mass="189601" checksum="BBD4F68A5E89D35E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV59</accession>
    <name>Q5CV59_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ser/Thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_5320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627410.1">
        <property type="nucleotide sequence ID" value="XM_627410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV59"/>
    <dbReference type="STRING" id="353152.Q5CV59"/>
    <dbReference type="GeneID" id="3374211"/>
    <dbReference type="KEGG" id="cpv:cgd8_5320"/>
    <dbReference type="InParanoid" id="Q5CV59"/>
    <dbReference type="OrthoDB" id="343384at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="1"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="345" mass="39608" checksum="380487AEAD2C73A4" modified="2005-04-12" version="1">MFSQSLLMCHKNFVRINEVIQDQSYPFSIFVMEYLPHSCMKWNSKTQSYQAPTINSNMEDVNKVYTYHGSKLIFSQVLEGVKYLHSKGVSGIYFTPESIKLSHSLGETYIDKNGKKLTQLLLVSSTKSNNKLENSVKNKSKIEVDPELFEYWKPAKSVNISNEFDSAAISHIKHIIQEKKSLPADIQNDSFLFNPIPFVEDLRNFYNTELIQNNIRSEKGKLMVKMSSPFKGMATNHKDILFSGMFIKLAKSFQNIFLGNKWLSPPELFSRMFNSLNSEVDLRKCDVWNLGVLLHCLLVGVPPTLVNKNVIIDKKIPKEVKVLLLSLLKVDPLLRPSIFDIEQYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVE5</accession>
    <name>Q5CVE5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S15A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_4360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89733.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627324.1">
        <property type="nucleotide sequence ID" value="XM_627324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVE5"/>
    <dbReference type="FunCoup" id="Q5CVE5">
        <property type="interactions" value="380"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVE5"/>
    <dbReference type="GeneID" id="3374660"/>
    <dbReference type="KEGG" id="cpv:cgd8_4360"/>
    <dbReference type="InParanoid" id="Q5CVE5"/>
    <dbReference type="OMA" id="LPAKNFG"/>
    <dbReference type="OrthoDB" id="10250260at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.30:FF:000001">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S15a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000630">
        <property type="entry name" value="Ribosomal_uS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047863">
        <property type="entry name" value="Ribosomal_uS8_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035987">
        <property type="entry name" value="Ribosomal_uS8_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003115">
        <property type="entry name" value="PRK04034.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11758">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S15A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00410">
        <property type="entry name" value="Ribosomal_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56047">
        <property type="entry name" value="Ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00053">
        <property type="entry name" value="RIBOSOMAL_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89733.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="137" mass="15642" checksum="103C6DE5213DB896" modified="2005-04-12" version="1" fragment="single">RSKNTEKMVRVSVLSDCLKAILNAEKMGRRQVLIRPSSKVIIKFLQCMQRRGYIGEFEVVDDRRAGKICIELLGRLNKCGVISPRYDVPLSDIEQISTDLLPSRQFGYIVLSTSYGIMDQEEARRKHTGGKILGFFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVI3</accession>
    <name>Q5CVI3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit gamma</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit gamma</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_3940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Acts as a component of the translation initiation factor 2B (eIF2B) complex, which catalyzes the exchange of GDP for GTP on the eukaryotic initiation factor 2 (eIF2) complex gamma subunit. Its guanine nucleotide exchange factor activity is repressed when bound to eIF2 complex phosphorylated on the alpha subunit, thereby limiting the amount of methionyl-initiator methionine tRNA available to the ribosome and consequently global translation is repressed.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627286.1">
        <property type="nucleotide sequence ID" value="XM_627286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVI3"/>
    <dbReference type="FunCoup" id="Q5CVI3">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVI3"/>
    <dbReference type="GeneID" id="3374590"/>
    <dbReference type="KEGG" id="cpv:cgd8_3940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3940"/>
    <dbReference type="InParanoid" id="Q5CVI3"/>
    <dbReference type="OMA" id="NCVINPK"/>
    <dbReference type="OrthoDB" id="285674at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04198">
        <property type="entry name" value="eIF-2B_gamma_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051960">
        <property type="entry name" value="eIF2B_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45989:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 12" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="10">
        <location>
            <begin position="15"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="EIF2B subunit epsilon/gamma LbH" evidence="11">
        <location>
            <begin position="396"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00045373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF25084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="500" mass="56208" checksum="D96320467DABFFD4" modified="2005-04-12" version="1">MTSNNERFLYSSEFKGVIFAGGSGRMLGPLAKNISKAMIPVCNKPMIWYPLSNLIQHRIRDICIFCEEEFENSIRKYISETFSNDTIIKRFEFEETYQQNIKIIGLKEDESLLESSGTWSILSEYGKEFLRDSDFFVLTCDVIGPLDLLGLANKHRLTQAVCTILLTESPDLSKIKGSGKQTSNSNNQAQANPIGGISVDLQKDKNRSIFVIDEKDEVILSIKDFYSAKQENEVSELSKLQLFWHPNVSLRTDLVDLHVYLFKSSIFKILEIASGSQKISTIEYPEDGIESIRLELLPFLAKNQHVPGSELWGRSKFDCYHFLDDEITTSNDSSVKFTKIDLPPKIEGTSVSYFLQKLPQNSSRVNTIMALHDCNLAATSPAYFPAWLAEEHDIGTNVGKEVIIGQNCNLGKSVQLRRCVIGSNVEIGDGSKIVNCVILDNTKIGSKCTIQNSVIGQYSEIGDSCKISYSVIEHYFKVDANSKSQGEIMEKRDELFEISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVQ4</accession>
    <name>Q5CVQ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Endoplasmic reticulum oxidoreductin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">cgd8_3190</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 17">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="4">May function both as a monomer and a homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Lumenal side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EROs family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627215.1">
        <property type="nucleotide sequence ID" value="XM_627215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVQ4"/>
    <dbReference type="SMR" id="Q5CVQ4"/>
    <dbReference type="FunCoup" id="Q5CVQ4">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVQ4"/>
    <dbReference type="GeneID" id="3374242"/>
    <dbReference type="KEGG" id="cpv:cgd8_3190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3190"/>
    <dbReference type="InParanoid" id="Q5CVQ4"/>
    <dbReference type="OMA" id="PCGIRSE"/>
    <dbReference type="OrthoDB" id="269384at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071949">
        <property type="term" value="F:FAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016972">
        <property type="term" value="F:thiol oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007266">
        <property type="entry name" value="Ero1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037192">
        <property type="entry name" value="ERO1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613:SF0">
        <property type="entry name" value="ERO1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12613">
        <property type="entry name" value="ERO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04137">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017205">
        <property type="entry name" value="ERO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110019">
        <property type="entry name" value="ERO1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13 18" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0249">Electron transport</keyword>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 17" id="KW-0274">FAD</keyword>
    <keyword evidence="6" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="19" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="333"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="359"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="16">
        <location>
            <position position="299"/>
        </location>
    </feature>
    <feature type="active site" evidence="16">
        <location>
            <position position="302"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="145"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="153"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="18">
        <location>
            <begin position="299"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="PIRSR" id="PIRSR017205-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EAK89492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="395" mass="45729" checksum="DC6DA47DA3F221F4" modified="2005-04-12" version="1">MRLIAAHILSFYLTVLELIGDGNVIFIFKSLQRNGFRPDLRLNGLPTTNELFQDAQILQEKMEKIRLMNSIRIFALDLSQNCIFEENKRNSCGDTGKCQVMGNESDLSSTLFGIDKANDINIADNGNCNEKKTKVDMLKNPPSNTQYKGGEVWRHIYYEIEKVDFPLLKKLISGVQSNIAIHASERYRKIRDDDYDYSLLNFINKFVLFEDRGVNLLVTFHYIVQSICILGPSFDKFMKDLDNSAENTKLKEEVKDIFNKSHYYSCRPEYKRNIIPPQFLPKLEKFFKTFISTLGCVECEKCILHGTIKGNTLDLTVKALGGSKNIILNPTYFVTYLNGLYIFSSSITIIDLFTFRVRIFLAFSLFIAIVFFFCLKRRVSSYLNKRREITHKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVR2</accession>
    <name>Q5CVR2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">valine--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.9</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Valyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd8_3100</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Val) + L-valine + ATP = L-valyl-tRNA(Val) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:10704"/>
            <dbReference type="Rhea" id="RHEA-COMP:9672"/>
            <dbReference type="Rhea" id="RHEA-COMP:9708"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57762"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78537"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.9"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.9" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627207.1">
        <property type="nucleotide sequence ID" value="XM_627207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVR2"/>
    <dbReference type="FunCoup" id="Q5CVR2">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVR2"/>
    <dbReference type="GeneID" id="3374320"/>
    <dbReference type="KEGG" id="cpv:cgd8_3100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3100"/>
    <dbReference type="InParanoid" id="Q5CVR2"/>
    <dbReference type="OMA" id="LDTWMDS"/>
    <dbReference type="OrthoDB" id="629407at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004832">
        <property type="term" value="F:valine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006438">
        <property type="term" value="P:valyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07962">
        <property type="entry name" value="Anticodon_Ia_Val"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00817">
        <property type="entry name" value="ValRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000020">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000078">
        <property type="entry name" value="Valine--tRNA ligase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02004">
        <property type="entry name" value="Val_tRNA_synth_type1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002300">
        <property type="entry name" value="aa-tRNA-synth_Ia"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033705">
        <property type="entry name" value="Anticodon_Ia_Val"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013155">
        <property type="entry name" value="M/V/L/I-tRNA-synth_anticd-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009008">
        <property type="entry name" value="Val/Leu/Ile-tRNA-synth_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002303">
        <property type="entry name" value="Valyl-tRNA_ligase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004349">
        <property type="entry name" value="PRK05729.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00422">
        <property type="entry name" value="valS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946:SF109">
        <property type="entry name" value="VALINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11946">
        <property type="entry name" value="VALYL-TRNA SYNTHETASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08264">
        <property type="entry name" value="Anticodon_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00133">
        <property type="entry name" value="tRNA-synt_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00986">
        <property type="entry name" value="TRNASYNTHVAL"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50677">
        <property type="entry name" value="ValRS/IleRS/LeuRS editing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-tRNA synthetase class Ia" evidence="13">
        <location>
            <begin position="38"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="domain" description="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase anticodon-binding" evidence="14">
        <location>
            <begin position="747"/>
            <end position="901"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF08264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK89484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1042" mass="120262" checksum="496CAF73D65933E5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVR8</accession>
    <name>Q5CVR8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627201.1">
        <property type="nucleotide sequence ID" value="XM_627201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVR8"/>
    <dbReference type="STRING" id="353152.Q5CVR8"/>
    <dbReference type="GeneID" id="3374315"/>
    <dbReference type="KEGG" id="cpv:cgd8_3030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3030"/>
    <dbReference type="InParanoid" id="Q5CVR8"/>
    <dbReference type="OrthoDB" id="343958at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="232" mass="27430" checksum="9A4FF5AF69913614" modified="2005-04-12" version="1">MIFLPKRPNKRYAGQFLLIIFLFVFYKLAFSSEISEISESNQYDLENENISKRPEGATSIPIKKKLFENFRKEVTVDKYYTKDGKKVKVILVRKRRPAFNWLRKWRNKRKIKNKAKKRYKMNRDRKSKKPNILKRVFKRKKMNDKSEEDAKISDVNYAKENEESVSKSDIFEEDTEVNKNEEDEPRTKEPDTQLDDTAPSPSRTSSYERSSITGENTDPTDMKTSTFDISAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVT3</accession>
    <name>Q5CVT3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">DNAJ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_2860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627186.1">
        <property type="nucleotide sequence ID" value="XM_627186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVT3"/>
    <dbReference type="STRING" id="353152.Q5CVT3"/>
    <dbReference type="GeneID" id="3374322"/>
    <dbReference type="KEGG" id="cpv:cgd8_2860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2860"/>
    <dbReference type="InParanoid" id="Q5CVT3"/>
    <dbReference type="OMA" id="FSMENND"/>
    <dbReference type="OrthoDB" id="1717591at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031982">
        <property type="term" value="C:vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072318">
        <property type="term" value="P:clathrin coat disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072583">
        <property type="term" value="P:clathrin-dependent endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172">
        <property type="entry name" value="AUXILIN/CYCLIN G-ASSOCIATED KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23172:SF19">
        <property type="entry name" value="J DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="326" mass="38163" checksum="ACB58EA88A597A72" modified="2005-04-12" version="1">MDFIKKSLSALSTDSIKKHNSEHIFYCIQYANRFGEYHEPEQFNLVQSKDKLNFRSITLERIKEIIPKYKFCCCYSKNCLCDISVRYKSHDSNGIYPWVWCDLVTDQDTATPYNSKIILKILVFVNFSSSNYDGIHTKSVNSNYEAKTVNMCMPYETDEKEYVDRSNSKIQNNIFQAPTPTKFDNSDDSNFIDIVDDEQTKFLSNKKSFTSQKVLESRILESSNDEKSDNFGYEDLVEEISRWSRKPDGSYKDIRVLLSSLQQVLWENAQWEPIEFSKLMSDIELVKKAYRKAIILCHPDKNHNESEKHKSRAHLIFMAINESNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVV8</accession>
    <name>Q5CVV8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine hydroxymethyltransferase</fullName>
            <ecNumber evidence="8">2.1.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd8_2610</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Interconversion of serine and glycine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine</text>
            <dbReference type="Rhea" id="RHEA:15481"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15636"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:57453"/>
            <dbReference type="EC" id="2.1.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 7 8">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">One-carbon metabolism; tetrahydrofolate interconversion.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the SHMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.2.1" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627161.1">
        <property type="nucleotide sequence ID" value="XM_627161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVV8"/>
    <dbReference type="FunCoup" id="Q5CVV8">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVV8"/>
    <dbReference type="GeneID" id="3374577"/>
    <dbReference type="KEGG" id="cpv:cgd8_2610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2610"/>
    <dbReference type="InParanoid" id="Q5CVV8"/>
    <dbReference type="OMA" id="CQFANVQ"/>
    <dbReference type="OrthoDB" id="10265628at2759"/>
    <dbReference type="UniPathway" id="UPA00193"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004372">
        <property type="term" value="F:glycine hydroxymethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019264">
        <property type="term" value="P:glycine biosynthetic process from serine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035999">
        <property type="term" value="P:tetrahydrofolate interconversion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00378">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001085">
        <property type="entry name" value="Ser_HO-MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049943">
        <property type="entry name" value="Ser_HO-MeTrfase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019798">
        <property type="entry name" value="Ser_HO-MeTrfase_PLP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039429">
        <property type="entry name" value="SHMT-like_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000586">
        <property type="entry name" value="PRK00011.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11680:SF35">
        <property type="entry name" value="SERINE HYDROXYMETHYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00464">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000412">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00096">
        <property type="entry name" value="SHMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="6 7 8" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Serine hydroxymethyltransferase-like" evidence="9">
        <location>
            <begin position="9"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="7">
        <location>
            <position position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000412-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="445" mass="49759" checksum="A59B3676EB921BAB" modified="2005-04-12" version="1">MVFLQEKSLKELDPIMYELINEEYDRQINGLEMIASENFVSKGVLDSLSSTFSMFNNDKNMELNSTSAQELLELTNERALKAYGLDPEVWGANVKPHSGSPANFAVLNAVLKPNDRIMGLSLQHGGHLTHGHYTNLKRVNCSSHYFESLPYVTDLEGVIDYDKLEENAILFRPKMIIAGASGYPRMINFKRFRDICDKVKAYLMVDIAHYSGLVVAGKYPSPKDYADFITTTSHKTLRGPRSAIIFYRKDVESKIRVKIDESVSKEIQSSIHFNQVAALCFQLKQVVSASWVKYASRVLESSQLLCKLLEESGIKILTNGTDSHKILIDTRSLNISGAKAEKALEVCEISTSRSSLPCDGRTMNCSGVRLGTAALASRGMELDDFKFVSRIIVEVLTTARDIQKDGETLAEFVSNIKASPAIENIRQTVRKFASSFEFVSIVDKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVX5</accession>
    <name>Q5CVX5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ser/Thr protein kinase with MORN repeats at the N-terminus and a sterile alpha motif (SAM domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_2430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627144.1">
        <property type="nucleotide sequence ID" value="XM_627144.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVX5"/>
    <dbReference type="STRING" id="353152.Q5CVX5"/>
    <dbReference type="GeneID" id="3374464"/>
    <dbReference type="KEGG" id="cpv:cgd8_2430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2430"/>
    <dbReference type="InParanoid" id="Q5CVX5"/>
    <dbReference type="OMA" id="IHHEKVY"/>
    <dbReference type="OrthoDB" id="312720at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.50">
        <property type="entry name" value="Transcription Factor, Ets-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001660">
        <property type="entry name" value="SAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013761">
        <property type="entry name" value="SAM/pointed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF298">
        <property type="entry name" value="MIXED LINEAGE KINASE DOMAIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00536">
        <property type="entry name" value="SAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00109">
        <property type="entry name" value="TYRKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00454">
        <property type="entry name" value="SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47769">
        <property type="entry name" value="SAM/Pointed domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50105">
        <property type="entry name" value="SAM_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM" evidence="8">
        <location>
            <begin position="292"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="386"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="415"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="659" mass="75640" checksum="35AC7968537A7E5C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWH4</accession>
    <name>Q5CWH4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_5070</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 10">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Endoplasmic reticulum membrane</location>
            <topology evidence="2 10">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the OST1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627830.1">
        <property type="nucleotide sequence ID" value="XM_627830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWH4"/>
    <dbReference type="FunCoup" id="Q5CWH4">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWH4"/>
    <dbReference type="GeneID" id="3375826"/>
    <dbReference type="KEGG" id="cpv:cgd6_5070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5070"/>
    <dbReference type="InParanoid" id="Q5CWH4"/>
    <dbReference type="OMA" id="RYEYARE"/>
    <dbReference type="OrthoDB" id="310030at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007676">
        <property type="entry name" value="Ribophorin_I"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21049">
        <property type="entry name" value="RIBOPHORIN I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04597">
        <property type="entry name" value="Ribophorin_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 10" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005143582" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1" evidence="10">
        <location>
            <begin position="27"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="451"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK90081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="487" mass="56257" checksum="6AFE3360F1A16BE4" modified="2005-04-12" version="1">MLKMSGIKMYFLSILVLFSWISIVIGGEGNLDELVSTQVTRTFYLTKRVAKVVMEVKLKSIKDEISSFEYVFALPEDQFSRIGFISAGTSSISSNNFKVEKIEAEKSFKIEVGHLSDNERTIFIEYHMGNPYSALPKAIRLGENQLLVFEDELRLRNKYKVTKEKIVIQFLAGTIIERVIPTNMKRQENKVVHLVSQDKQGDKFLVHFSLNNHLVYFDSVSRIIEISHWGNVKVKEEYSGINMAAHNKGEFHRKEIMILSGQGFARMRNPGTVLPHNTHVCLFVDHVLPYRAVGLEYYDQIGNISYSNAWRVGASHTMLQIQPRSPLMGGWQFDYIVEYNLPLETVVFYDQSLKLYMLNLTMIPSAKGIYSENVNTQIRFPTGSSDISIDFPKNNNIPSLIQNDELDHYFGWLDILKPRPVLVYNMSSYYIPEHLLLNYKFQAYYRIKSHIITFSGTFLISFLVFIPFLIVILIKRLNNHSVKIKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWK9</accession>
    <name>Q5CWK9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative apicomplexan-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90053.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627795.1">
        <property type="nucleotide sequence ID" value="XM_627795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWK9"/>
    <dbReference type="GeneID" id="3375798"/>
    <dbReference type="KEGG" id="cpv:cgd6_4660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4660"/>
    <dbReference type="InParanoid" id="Q5CWK9"/>
    <dbReference type="OMA" id="WEYWEAY"/>
    <dbReference type="OrthoDB" id="387569at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="484"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="496"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90053.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="526" mass="59480" checksum="8CE24FD5C912FD51" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWQ1</accession>
    <name>Q5CWQ1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd6_4200</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Fe(3+)</name>
            <dbReference type="ChEBI" id="CHEBI:29034"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. PP-2B subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627753.1">
        <property type="nucleotide sequence ID" value="XM_627753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWQ1"/>
    <dbReference type="FunCoup" id="Q5CWQ1">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWQ1"/>
    <dbReference type="GeneID" id="3375767"/>
    <dbReference type="KEGG" id="cpv:cgd6_4200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4200"/>
    <dbReference type="InParanoid" id="Q5CWQ1"/>
    <dbReference type="OMA" id="YPAACNF"/>
    <dbReference type="OrthoDB" id="5593063at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033192">
        <property type="term" value="F:calmodulin-dependent protein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097720">
        <property type="term" value="P:calcineurin-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07416">
        <property type="entry name" value="MPP_PP2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000031">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041751">
        <property type="entry name" value="MPP_PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043360">
        <property type="entry name" value="PP2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45673">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0112">Calmodulin-binding</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="14">
        <location>
            <begin position="144"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK90022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="504" mass="57688" checksum="79E719322A693840" modified="2007-04-03" version="1">MQPLKDPLNDRVVKESDPPPPLPITEELLFPNGIEGNPDWRILKSHLLREGRVRKDHLLEIVRRTSEITANESNLLRLRDPITVVGDIHGQYYDLVKLLDVGGDPETTQYLFLGDYVDRGSFSIEVLLLLYSLKLNYPDTVYLLRGNHECRQMTTFFNFRDECEYKYDSTVHGYFMESFDTLPIAAIINGKFFCVHGGLSPELRSVDQILTINRFQEPPRSGLYCDILWADPIDEKDETETSEEHFVTNDVRGCSYFFATQASNKFLDQNGLLSIVRAHEAQLEGFKMHSPNVKTRFPSVITIFSAPNYCDVYNNKGAILKFENNTLNIQQFNFSAHPYYLPNFLDIFSWSLPFVSEKVTEMLYSIIQPVATSSSEPMELEEEDLPDDVRRLMDAFCINEDGKLPEEVASLGSSIIRSAQPASSVISKERADTLRKKVQSVARIMRVFSTLREQNELIVKLKGVTPGHRIPMGLLLGGRDALENELEKFNKVKTMDAYNERRPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWR3</accession>
    <name>Q5CWR3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 NT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_4070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627741.1">
        <property type="nucleotide sequence ID" value="XM_627741.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWR3"/>
    <dbReference type="GeneID" id="3375755"/>
    <dbReference type="KEGG" id="cpv:cgd6_4070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4070"/>
    <dbReference type="InParanoid" id="Q5CWR3"/>
    <dbReference type="OMA" id="DIRVEWI"/>
    <dbReference type="OrthoDB" id="340336at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019448">
        <property type="entry name" value="NT-C2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10358">
        <property type="entry name" value="NT-C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51840">
        <property type="entry name" value="C2_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2 NT-type" evidence="3">
        <location>
            <begin position="7"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="288"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="648"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="367"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="445"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="572"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="298"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="650"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="661"/>
            <end position="674"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="691" mass="79007" checksum="CFA193D4E19F54F3" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWR6</accession>
    <name>Q5CWR6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cullin domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_4040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90007.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627738.1">
        <property type="nucleotide sequence ID" value="XM_627738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWR6"/>
    <dbReference type="GeneID" id="3375752"/>
    <dbReference type="KEGG" id="cpv:cgd6_4040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4040"/>
    <dbReference type="InParanoid" id="Q5CWR6"/>
    <dbReference type="OMA" id="ECNIAIA"/>
    <dbReference type="OrthoDB" id="342492at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="4">
        <location>
            <begin position="603"/>
            <end position="984"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90007.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1204" mass="141820" checksum="A0B1F1FF9F53E68F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWU3</accession>
    <name>Q5CWU3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">40S ribosomal protein S30</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_3710</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic ribosomal protein eS30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627711.1">
        <property type="nucleotide sequence ID" value="XM_627711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWU3"/>
    <dbReference type="STRING" id="353152.Q5CWU3"/>
    <dbReference type="GeneID" id="3375901"/>
    <dbReference type="KEGG" id="cpv:cgd6_3710"/>
    <dbReference type="InParanoid" id="Q5CWU3"/>
    <dbReference type="OMA" id="YNTQNVP"/>
    <dbReference type="OrthoDB" id="3446at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006846">
        <property type="entry name" value="Ribosomal_eS30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S30/UBIQUITIN-LIKE PROTEIN FUBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12650:SF15">
        <property type="entry name" value="RIBOSOMAL PROTEIN S30, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04758">
        <property type="entry name" value="Ribosomal_S30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1 3 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="30"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU364011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="59" mass="6692" checksum="DDD8FEDC78AEE354" modified="2005-04-12" version="1" fragment="single">NMAKAHGSLARAGKVKNQTPRVEKQEKKKALTGRAKKRQQYNRRFVSVVAGRRKCNPQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWZ7</accession>
    <name>Q5CWZ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_3110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627657.1">
        <property type="nucleotide sequence ID" value="XM_627657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWZ7"/>
    <dbReference type="GeneID" id="3375686"/>
    <dbReference type="KEGG" id="cpv:cgd6_3110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3110"/>
    <dbReference type="InParanoid" id="Q5CWZ7"/>
    <dbReference type="OMA" id="FAQDCAP"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="132" mass="14100" checksum="E8A531676594819C" modified="2005-04-12" version="1">MRVKWVPIPTPPRPVPAIPPIPPVPPIPPVPPIPPVPPIPPVPPIPPVPPIPPVPPIPPIPPIPANPIVPAAPVPLKNGFCSFILEITRLIIVLNPSISEENCFFRRLLLLIPFSLSLLKSVDEVIFGIGGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX14</accession>
    <name>Q5CX14_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627640.1">
        <property type="nucleotide sequence ID" value="XM_627640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX14"/>
    <dbReference type="GeneID" id="3376164"/>
    <dbReference type="KEGG" id="cpv:cgd6_2920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2920"/>
    <dbReference type="InParanoid" id="Q5CX14"/>
    <dbReference type="OMA" id="NDILCKW"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="421" mass="48282" checksum="B78C4A18409DD75F" modified="2007-04-03" version="1">MNLHNDLTSGKAVKFQLLAFGLSILIFMGGTFYMLINSSRNLENGKQRIFLELEEKDITNQKSLDELDKLNDSMLRISLKLSESKDMFDTIGASINKIAKYVEANEKNMTAKEFIIKEESKNGFVLDSVLFPCKYSFDGPIYILLTTTPKRIDNLGKYLDLLHKQTYGIKEVILSIPYIFERTGEEYPPIPGYLQDKNRFPLLRILRGKDYGPATKFLLPIEIGNIPEDSGLVILDDDTRYSRHLVCDYIYIHEKFPEAALGRRGQAFHDKCDPTYRTDRTHRVSHDQKSANFVIRSVDLLSGVGTYFIQKKFISKDILTLKNNCPTETINHMFFTDDILISGYLAYKNISRIAFSDELSIEDLNRPYLLGSGPGALWDINKETFHNDNSTAAFGLYWGCRNKDTIVSKHGEILCRWRNEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX25</accession>
    <name>Q5CX25_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_2810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRN3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89914.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627629.1">
        <property type="nucleotide sequence ID" value="XM_627629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX25"/>
    <dbReference type="STRING" id="353152.Q5CX25"/>
    <dbReference type="GeneID" id="3376154"/>
    <dbReference type="KEGG" id="cpv:cgd6_2810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2810"/>
    <dbReference type="InParanoid" id="Q5CX25"/>
    <dbReference type="OMA" id="HEIWCEN"/>
    <dbReference type="OrthoDB" id="26970at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001042">
        <property type="term" value="F:RNA polymerase I core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001181">
        <property type="term" value="F:RNA polymerase I general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006361">
        <property type="term" value="P:transcription initiation at RNA polymerase I promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007991">
        <property type="entry name" value="RNA_pol_I_trans_ini_fac_RRN3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790:SF0">
        <property type="entry name" value="RNA POLYMERASE I-SPECIFIC TRANSCRIPTION INITIATION FACTOR RRN3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12790">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IA RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05327">
        <property type="entry name" value="RRN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="816"/>
            <end position="840"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="861"/>
            <end position="882"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89914.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="882" mass="102027" checksum="9244A2980C391E88" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2012-05-16" modified="2025-06-18" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX58</accession>
    <name>CUTA_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName>Divalent-cation tolerance protein cutA homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name type="ORF">cgd6_2410</name>
    </gene>
    <organism>
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Homotrimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CutA family.</text>
    </comment>
    <comment type="sequence caution" evidence="2">
        <conflict type="erroneous gene model prediction">
            <sequence resource="EMBL-CDS" id="EAK90138" version="1"/>
        </conflict>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90138.1"/>
        <property type="status" value="ALT_SEQ"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627596.1">
        <property type="nucleotide sequence ID" value="XM_627596.1"/>
    </dbReference>
    <dbReference type="PDB" id="4E98">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B/C=2-117"/>
    </dbReference>
    <dbReference type="PDBsum" id="4E98"/>
    <dbReference type="AlphaFoldDB" id="Q5CX58"/>
    <dbReference type="SMR" id="Q5CX58"/>
    <dbReference type="FunCoup" id="Q5CX58">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX58"/>
    <dbReference type="EnsemblProtists" id="EAK90138">
        <property type="protein sequence ID" value="EAK90138"/>
        <property type="gene ID" value="cgd6_2410"/>
    </dbReference>
    <dbReference type="GeneID" id="3375883"/>
    <dbReference type="KEGG" id="cpv:cgd6_2410"/>
    <dbReference type="InParanoid" id="Q5CX58"/>
    <dbReference type="OrthoDB" id="2017693at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CX58"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010038">
        <property type="term" value="P:response to metal ion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004323">
        <property type="entry name" value="Ion_tolerance_CutA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011322">
        <property type="entry name" value="N-reg_PII-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015867">
        <property type="entry name" value="N-reg_PII/ATP_PRibTrfase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419">
        <property type="entry name" value="DIVALENT CATION TOLERANCE CUTA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23419:SF8">
        <property type="entry name" value="FI09726P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03091">
        <property type="entry name" value="CutA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54913">
        <property type="entry name" value="GlnB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000417424" description="Divalent-cation tolerance protein cutA homolog">
        <location>
            <begin position="1"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="25"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="59"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="74"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="89"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="strand" evidence="3">
        <location>
            <begin position="95"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="helix" evidence="3">
        <location>
            <begin position="105"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1"/>
    <evidence type="ECO:0000305" key="2"/>
    <evidence type="ECO:0007829" key="3">
        <source>
            <dbReference type="PDB" id="4E98"/>
        </source>
    </evidence>
    <sequence length="117" mass="13284" checksum="65E0B7E17DDC3AF9" modified="2012-05-16" version="2">MINSNMTETKIESNIILIYISAPNQDEATSIAKTLVDEELCACVSIIPSVRSIYKFKGQVHDENEVMLLVKTTSQLFTTLKEKVTEIHSYELPEIIATKVVYGNENYINWVNQTVRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX60</accession>
    <name>Q5CX60_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec1-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627594.1">
        <property type="nucleotide sequence ID" value="XM_627594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX60"/>
    <dbReference type="STRING" id="353152.Q5CX60"/>
    <dbReference type="GeneID" id="3376127"/>
    <dbReference type="KEGG" id="cpv:cgd6_2370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2370"/>
    <dbReference type="InParanoid" id="Q5CX60"/>
    <dbReference type="OMA" id="MQTIGEM"/>
    <dbReference type="OrthoDB" id="10262287at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.850">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043155">
        <property type="entry name" value="VPS33_dom3b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="702" mass="81415" checksum="DF676EB226D4CB66" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX65</accession>
    <name>Q5CX65_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Multi-domain chromatin protein with WD40 repeats, bromodomain and PHD domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_2320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627589.1">
        <property type="nucleotide sequence ID" value="XM_627589.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX65"/>
    <dbReference type="GeneID" id="3375763"/>
    <dbReference type="KEGG" id="cpv:cgd6_2320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2320"/>
    <dbReference type="InParanoid" id="Q5CX65"/>
    <dbReference type="OMA" id="AVNHSNT"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007010">
        <property type="term" value="P:cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008360">
        <property type="term" value="P:regulation of cell shape"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05529">
        <property type="entry name" value="Bromo_WDR9_I_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052060">
        <property type="entry name" value="Bromo_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266:SF17">
        <property type="entry name" value="BRWD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16266">
        <property type="entry name" value="WD REPEAT DOMAIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0853">WD repeat</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="173"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="8">
        <location>
            <begin position="1509"/>
            <end position="1587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="519"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="911"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="911"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="955"/>
            <end position="972"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1654" mass="190504" checksum="E8EB882C8031EF36" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXB2</accession>
    <name>Q5CXB2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Phosphatidylinositol 3-kinase PI3ka plus PI3Kc domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_1760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627542.1">
        <property type="nucleotide sequence ID" value="XM_627542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXB2"/>
    <dbReference type="FunCoup" id="Q5CXB2">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXB2"/>
    <dbReference type="GeneID" id="3376122"/>
    <dbReference type="KEGG" id="cpv:cgd6_1760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1760"/>
    <dbReference type="InParanoid" id="Q5CXB2"/>
    <dbReference type="OMA" id="NPSECHI"/>
    <dbReference type="OrthoDB" id="67688at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005777">
        <property type="term" value="C:peroxisome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034271">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034272">
        <property type="term" value="C:phosphatidylinositol 3-kinase complex, class III, type II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016303">
        <property type="term" value="F:1-phosphatidylinositol-3-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00864">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00896">
        <property type="entry name" value="PI3Kc_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.70">
        <property type="entry name" value="Phosphatidylinositol 3-kinase, accessory domain (PIK)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057756">
        <property type="entry name" value="PI3-kinase_type3/VPS34_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042236">
        <property type="entry name" value="PI3K_accessory_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF7">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00613">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00145">
        <property type="entry name" value="PI3Ka"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="4">
        <location>
            <begin position="270"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="631"/>
            <end position="928"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="943" mass="109271" checksum="47F88B55EAFC11C2" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXC0</accession>
    <name>Q5CXC0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Splicing factor U2AF U2 snRNP auxiliary factor large subunit 3 RRM domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_1680</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627534.1">
        <property type="nucleotide sequence ID" value="XM_627534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXC0"/>
    <dbReference type="STRING" id="353152.Q5CXC0"/>
    <dbReference type="GeneID" id="3376115"/>
    <dbReference type="KEGG" id="cpv:cgd6_1680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1680"/>
    <dbReference type="InParanoid" id="Q5CXC0"/>
    <dbReference type="OMA" id="DVRCECE"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="117"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="362"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="492" mass="56492" checksum="03B4944E7B6440BA" modified="2007-04-03" version="1">MKLKNQNELIYSNSSKFDKDSREFIISDLDKKFFLNEIDQIHFNNNTIEFGTIERSLARDHATNYQENSFKKQCSNKHIASYSEIPSDINQCELTEIVPAGTAYLNSTSFTSKPLREVYVGNLPQGITVTELLEYINRSIIKNSVSHTNGNPVVSAWINSDGKYAFCECRSIEEANTLLRLNNLLSFKGNLLRIGKPKVSENIIGDQPSNNSTLINQITQSTSIISPYFNNIPLVLKKKETILITGINKKFVLEDIKEMLSIKNIEILELIDYRNKYKIAICEGDLNTDITDKVVNKLGTEIKILRMKNCNSKVIHAVNNHLKNLSCIVRESNKLLLKTEKFENIQSKNVISLLLPQKPCRCILLSNILTVEELLIPSTYSSIHEEIHEKCLKYGEIYKTTIPIPERALSNKDQFNDPYFGRAFIFFYNVESAIKAKLDLFKMRFLGRNMKISYYCEHEFLHGNLFSCEPNRFDPIDDQELLKIINPIQVDC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXD8</accession>
    <name>Q5CXD8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCZ1/INTU/HSP4 first Longin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_1480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627516.1">
        <property type="nucleotide sequence ID" value="XM_627516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXD8"/>
    <dbReference type="FunCoup" id="Q5CXD8">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXD8"/>
    <dbReference type="GeneID" id="3376015"/>
    <dbReference type="KEGG" id="cpv:cgd6_1480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1480"/>
    <dbReference type="InParanoid" id="Q5CXD8"/>
    <dbReference type="OMA" id="DCQALHT"/>
    <dbReference type="OrthoDB" id="240546at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013176">
        <property type="entry name" value="Ccz1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13056:SF0">
        <property type="entry name" value="VACUOLAR FUSION PROTEIN CCZ1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="538" mass="62008" checksum="EBC1114BEA0A7712" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXF4</accession>
    <name>Q5CXF4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ring finger, membrane associated, possible signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_1290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627500.1">
        <property type="nucleotide sequence ID" value="XM_627500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXF4"/>
    <dbReference type="STRING" id="353152.Q5CXF4"/>
    <dbReference type="GeneID" id="3376003"/>
    <dbReference type="KEGG" id="cpv:cgd6_1290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1290"/>
    <dbReference type="InParanoid" id="Q5CXF4"/>
    <dbReference type="OMA" id="CRCEVEP"/>
    <dbReference type="OrthoDB" id="1302410at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45676:SF159">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45676">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL51-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="110"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="207" mass="24132" checksum="48F765FF4F83AF54" modified="2007-04-03" version="1">MLIAFSVCLLATIIFCNFALIFCRRIPCEFEGNRDVRHRNSFSIRISDRNSIVSQTISNEELSKIAPVKKYSSLSNKHYRREYNIYNKSSSFSGYLSSGSTHKSKNNYSCVICLNNICDEDLVRKLPCKHIYHFNCIDEWVKIKSNCPLCNINLTSIYNQNIRDRELMHSPNRIQNYEEVEFSEIYNSSNLLNDKLLASKFDVLIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXI5</accession>
    <name>Q5CXI5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cysteine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.16</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cysteinyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627469.1">
        <property type="nucleotide sequence ID" value="XM_627469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXI5"/>
    <dbReference type="FunCoup" id="Q5CXI5">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXI5"/>
    <dbReference type="GeneID" id="3375997"/>
    <dbReference type="KEGG" id="cpv:cgd6_960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_960"/>
    <dbReference type="InParanoid" id="Q5CXI5"/>
    <dbReference type="OMA" id="FHNDMKS"/>
    <dbReference type="OrthoDB" id="438179at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004817">
        <property type="term" value="F:cysteine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006423">
        <property type="term" value="P:cysteinyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00672">
        <property type="entry name" value="CysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000027">
        <property type="entry name" value="Cysteine--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1910">
        <property type="entry name" value="Cysteine-tRNA ligase, C-terminal anti-codon recognition domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00041">
        <property type="entry name" value="Cys_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015803">
        <property type="entry name" value="Cys-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024909">
        <property type="entry name" value="Cys-tRNA/MSH_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032678">
        <property type="entry name" value="tRNA-synt_1_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00435">
        <property type="entry name" value="cysS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890:SF3">
        <property type="entry name" value="CYSTEINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10890">
        <property type="entry name" value="CYSTEINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01406">
        <property type="entry name" value="tRNA-synt_1e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00983">
        <property type="entry name" value="TRNASYNTHCYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA synthetases class I catalytic" evidence="11">
        <location>
            <begin position="54"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="581" mass="66261" checksum="A709F82C7FCB0FB7" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXL3</accession>
    <name>Q5CXL3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Vacuolar membrane-associated protein Iml1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627441.1">
        <property type="nucleotide sequence ID" value="XM_627441.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXL3"/>
    <dbReference type="GeneID" id="3375861"/>
    <dbReference type="KEGG" id="cpv:cgd6_590"/>
    <dbReference type="InParanoid" id="Q5CXL3"/>
    <dbReference type="OMA" id="ISPRDLW"/>
    <dbReference type="OrthoDB" id="39497at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027244">
        <property type="entry name" value="IML1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048255">
        <property type="entry name" value="IML1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179">
        <property type="entry name" value="DEP DOMAIN CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13179:SF8">
        <property type="entry name" value="GATOR COMPLEX PROTEIN DEPDC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12257">
        <property type="entry name" value="IML1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar membrane-associated protein Iml1 N-terminal" evidence="1">
        <location>
            <begin position="101"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1198" mass="140295" checksum="201916CDE8617304" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXM1</accession>
    <name>Q5CXM1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Synaptobrevin/VAMP-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_510</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
            <orientation evidence="7">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627433.1">
        <property type="nucleotide sequence ID" value="XM_627433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXM1"/>
    <dbReference type="FunCoup" id="Q5CXM1">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXM1"/>
    <dbReference type="GeneID" id="3376044"/>
    <dbReference type="KEGG" id="cpv:cgd6_510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_510"/>
    <dbReference type="InParanoid" id="Q5CXM1"/>
    <dbReference type="OMA" id="HYIGIIR"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45806:SF1">
        <property type="entry name" value="SYNAPTOBREVIN HOMOLOG YKT6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0488">Methylation</keyword>
    <keyword evidence="4" id="KW-0564">Palmitate</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Longin" evidence="9">
        <location>
            <begin position="7"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="165"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="225" mass="26128" checksum="52A005A4DD2567BE" modified="2005-04-12" version="1">MKLLSVLLYKWDKEHPILLTSNYNLQDYNFFQRKTIQEHIAFHSRLLCSRVQQGNRVTVTFPQDIGHCHIYISNNGLGICCITSPDYPVRCAFSLLNEYLKTYIDSSKNHDVLFSSDFTTTTNNNNSNNNNNSIASNIITKDQNESIPECDEIFKKYQDPLNNDKIFKVQKDLDEVRDVMLKNIEDLLHRGETLDTLMQKSSDLSAASYQFYRSAKKNNQCCQLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXQ0</accession>
    <name>Q5CXQ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">LigT, 2 H domain protein, involved in RNA processing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_5370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628680.1">
        <property type="nucleotide sequence ID" value="XM_628678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXQ0"/>
    <dbReference type="GeneID" id="3372144"/>
    <dbReference type="KEGG" id="cpv:cgd7_5370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5370"/>
    <dbReference type="InParanoid" id="Q5CXQ0"/>
    <dbReference type="OMA" id="HEDYKTH"/>
    <dbReference type="OrthoDB" id="277832at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010738">
        <property type="term" value="P:regulation of protein kinase A signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1140.10">
        <property type="entry name" value="Cyclic phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019510">
        <property type="entry name" value="AKAP7-like_phosphoesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052641">
        <property type="entry name" value="AKAP7_isoform_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009097">
        <property type="entry name" value="Cyclic_Pdiesterase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934:SF2">
        <property type="entry name" value="A-KINASE ANCHOR PROTEIN 7-LIKE PHOSPHOESTERASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15934">
        <property type="entry name" value="RNA 2',3'-CYCLIC PHOSPHODIESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10469">
        <property type="entry name" value="AKAP7_NLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55144">
        <property type="entry name" value="LigT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="A-kinase anchor protein 7-like phosphoesterase" evidence="2">
        <location>
            <begin position="150"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="391" mass="44550" checksum="FE563902C5CF0A1F" modified="2005-04-12" version="1">MASKKIKESKKQLNEESGVTGAEGSYNDHNSPQGSHFHSNEIEKLDEMILFPPVKAVEIRDNIFQRSGDKERGRMVSEYVDLSQIPASLLKRLSFKPTSEVQVIKEDSNFSNSESEESEEATKLGSNFDHLEFVDYLEEKDQNIKVNQTPTHFFSLSFNQHSLNLFKEFKALKKVVNESAEYGEIKPTFFIGEKKLHITLGLVRAETPQELLQCENALFELKETQEFRDILEESSSEKGFPVELHGLGYFGSPYNSRVVYAKISENHKIAMIKRLWIKLCEILIKYGVNLTISDSNSEISNKSQNLKDSIVQDYNPHVTFINTKYGNKSEKQKLTFNSSSLVKAYSKKSFGPGYISEIQLNELSGIQEIGVISNEEQVYKTISSIKINRNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXT6</accession>
    <name>Q5CXT6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">H(+)-transporting two-sector ATPase</fullName>
            <ecNumber evidence="2">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd7_5000</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628644.1">
        <property type="nucleotide sequence ID" value="XM_628642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXT6"/>
    <dbReference type="FunCoup" id="Q5CXT6">
        <property type="interactions" value="191"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXT6"/>
    <dbReference type="GeneID" id="3371954"/>
    <dbReference type="KEGG" id="cpv:cgd7_5000"/>
    <dbReference type="InParanoid" id="Q5CXT6"/>
    <dbReference type="OMA" id="RIVKTFW"/>
    <dbReference type="OrthoDB" id="1676488at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18111">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18119">
        <property type="entry name" value="ATP-synt_V_A-type_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01134">
        <property type="entry name" value="V_A-ATPase_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1140.10:FF:000002">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.20:FF:000009">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000008">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000052">
        <property type="entry name" value="V-type proton ATPase catalytic subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00309">
        <property type="entry name" value="ATP_synth_A_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031686">
        <property type="entry name" value="ATP-synth_a_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005725">
        <property type="entry name" value="ATPase_V1-cplx_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022878">
        <property type="entry name" value="V-ATPase_asu"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003220">
        <property type="entry name" value="PRK04192.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01042">
        <property type="entry name" value="V-ATPase_V1_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607:SF1">
        <property type="entry name" value="H(+)-TRANSPORTING TWO-SECTOR ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43607">
        <property type="entry name" value="V-TYPE PROTON ATPASE CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16886">
        <property type="entry name" value="ATP-synt_ab_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="11">
        <location>
            <begin position="16"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="domain" description="ATPsynthase alpha/beta subunit barrel-sandwich" evidence="12">
        <location>
            <begin position="119"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="10">
        <location>
            <begin position="226"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="13">
        <location>
            <begin position="459"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK90651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="613" mass="68280" checksum="A028F9143F152183" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXT9</accession>
    <name>Q5CXT9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein phosphatase 2A regulatory subunit (Contains a conserved version of EF hands)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_4970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628641.1">
        <property type="nucleotide sequence ID" value="XM_628639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXT9"/>
    <dbReference type="STRING" id="353152.Q5CXT9"/>
    <dbReference type="GeneID" id="3372233"/>
    <dbReference type="KEGG" id="cpv:cgd7_4970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4970"/>
    <dbReference type="InParanoid" id="Q5CXT9"/>
    <dbReference type="OrthoDB" id="5586at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041534">
        <property type="entry name" value="EF-hand_13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095:SF0">
        <property type="entry name" value="MIP22305P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14095">
        <property type="entry name" value="PHOSPHATASE 2A REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17958">
        <property type="entry name" value="EF-hand_13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="327"/>
            <end position="362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="467" mass="55824" checksum="CD88651FD9CDC1A7" modified="2005-04-12" version="1">MILLEKDVQCLFFEFLSGKINISINDENSKLGNYNIKLTNDMKRESSIVIKQPENEDIVEKLKEIFQGKENNCISYDEWEILIVEGLLGMNKLCSGTLYKIMNNEKDYEELVSKNDLNNKCSIQIEYNKVKDLFCKKMNMVQNDGGLNYFKLLSKLSRSKDCIYPFGFKPILNEIVNRHKALKFLVKDEIFKELYIETIISRIYYELDILEIRKLRFKDFKNTDLVDILINMKGNESFDDLINYFNYQHFYVLYSRFVELDSDEDRYLTLDDFKKHDSGSLTMNALTRIWECNICEKKELFEDELNRNRRMSYHDFIYFYISDEDKTTERSIRYWFEIIDFDCDGWISFSEIDYFFREQKSRCNDLNYFIPELNNISCMMNDLLMPGIQGRYRLDDFLRNKLIAGHFFNVLVNTKKCLTSMFMDAELNSIQAVILPKLGYKSPSPWELHCQYQYQIIQDSRNDQNIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXY0</accession>
    <name>Q5CXY0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide-containing protein with transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628600.1">
        <property type="nucleotide sequence ID" value="XM_628598.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372179"/>
    <dbReference type="KEGG" id="cpv:cgd7_4490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4490"/>
    <dbReference type="InParanoid" id="Q5CXY0"/>
    <dbReference type="OMA" id="INHINIC"/>
    <dbReference type="OrthoDB" id="337738at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254528" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1633" mass="182968" checksum="D011F553BE39110A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY05</accession>
    <name>Q5CY05_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed RNA polymerase III subunit RPC9</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_4200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPC9 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628575.1">
        <property type="nucleotide sequence ID" value="XM_628573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY05"/>
    <dbReference type="GeneID" id="3372077"/>
    <dbReference type="KEGG" id="cpv:cgd7_4200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4200"/>
    <dbReference type="InParanoid" id="Q5CY05"/>
    <dbReference type="OMA" id="FHDVENM"/>
    <dbReference type="OrthoDB" id="1746530at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038846">
        <property type="entry name" value="RPC9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561">
        <property type="entry name" value="CALCITONIN GENE-RELATED PEPTIDE-RECEPTOR COMPONENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15561:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="134" mass="15894" checksum="371E9D5644B53AED" modified="2005-04-12" version="1">MKPKLSTWVPLSSSEVYEAVSKTDYDEIDKEFETPSLVFFKKSLKWYLESFHSVHLIPQKEFFSLAEALYSKYDLSQQEVMQIIDIRPKKQVELHCIIPDCEKRFSEEDIFQILKLVGEILINQEEKKCLEEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY13</accession>
    <name>Q5CY13_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 protein (Part of U3 processesome)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_4110</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628567.1">
        <property type="nucleotide sequence ID" value="XM_628565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY13"/>
    <dbReference type="FunCoup" id="Q5CY13">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY13"/>
    <dbReference type="GeneID" id="3372070"/>
    <dbReference type="KEGG" id="cpv:cgd7_4110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4110"/>
    <dbReference type="InParanoid" id="Q5CY13"/>
    <dbReference type="OMA" id="GPYHIDY"/>
    <dbReference type="OrthoDB" id="10251154at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000378">
        <property type="entry name" value="U3 small nucleolar RNA-associated protein 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012952">
        <property type="entry name" value="BING4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040315">
        <property type="entry name" value="WDR46/Utp7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085:SF3">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14085">
        <property type="entry name" value="WD-REPEAT PROTEIN BING4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08149">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01033">
        <property type="entry name" value="BING4CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BING4 C-terminal" evidence="7">
        <location>
            <begin position="348"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="444"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="484"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="453"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="497"/>
            <end position="511"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="529" mass="59385" checksum="FDC1BAADC5CF77AD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY29</accession>
    <name>Q5CY29_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628551.1">
        <property type="nucleotide sequence ID" value="XM_628549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY29"/>
    <dbReference type="GeneID" id="3372137"/>
    <dbReference type="KEGG" id="cpv:cgd7_3900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3900"/>
    <dbReference type="InParanoid" id="Q5CY29"/>
    <dbReference type="OMA" id="QIVHENC"/>
    <dbReference type="OrthoDB" id="341752at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="297" mass="34532" checksum="17907D2496D0E5B9" modified="2005-04-12" version="1">MRKVNFFFNLKPFSENLKKESIEAVKEVAERMMECLETFGERIVDQKKKFWQTIDYKLVRPAVSKINSFEFWLENNGVMEIPDVILKEYLYLMALVDDSKFIDVDKAEESISITNEPIVVEDNEQKEANIDSLIADINSTITQTRVILLEVEKFGKILEQKKTQLNTRIKGQQIVEVFSPVIDDLKIKYEHIKSEGTMESFQKLINEFCSALEERNELRYRLVHGEDRIEIPDSADKNELNQDVSIDQNVNIDSNNSQNQIIDSVNSIQEKSKRYTSVVDKNAMKLFARWSLPNHPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYB1</accession>
    <name>Q5CYB1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Rhomboid-like protease</fullName>
            <ecNumber evidence="11">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_3020</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 11">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Membrane</location>
            <topology evidence="2 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="11"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628469.1">
        <property type="nucleotide sequence ID" value="XM_628467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYB1"/>
    <dbReference type="STRING" id="353152.Q5CYB1"/>
    <dbReference type="GeneID" id="3372282"/>
    <dbReference type="KEGG" id="cpv:cgd7_3020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3020"/>
    <dbReference type="InParanoid" id="Q5CYB1"/>
    <dbReference type="OMA" id="KENERWH"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017092">
        <property type="entry name" value="Pept_S54_Rhomboid-like_Rom4/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037023">
        <property type="entry name" value="Rhomboid-like_ROM4_ROM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 11 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="114"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="184"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="213"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="400"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="175"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="10">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR037023-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK90309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="464" mass="51550" checksum="305C2E33D6F661CF" modified="2005-04-12" version="1">MSDRKIFDIQSLNSHTELMNQQMPLSEDSSVVLSKEGNSKELDITTESFKFDESDSSKNHVVQPKSEENIEGKSSLKNGRTIEIKRGKHTPRNSLFLTMFCCIGGDSSVARLKVSYLATTFFASSIIFVFIQELVISQLTNGYSIIKIPDGYLFGPPPQVVFDMGALDTNLVRNGQLARLFWSFWLHTGFIHLFINLSCQIILGIILETRWVIWRYAILYLLGGISGNLASAVLDPCTISAGSSACFFALLAGIIVLLLENWRNSRWQFLYVLLVIIASLIGISLSFMSNTDNWAHIGGFVAGLLWSFASMESFSRKSKALRKSIKSSGKNTIQLPSQDNVQLSLQIKPTDVEVGHSKSQFEETSIVDSISDNEAKNEYVKGRFIPANCACSGGVQTVRVISLLLLLSLLTIGFLFLLYKPLYTKFNLVLGHLSFSGIQKCSCCDSPEGVFWCSSSPTWIRRCG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYC7</accession>
    <name>Q5CYC7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein with predicted coiled coil regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_2860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628453.1">
        <property type="nucleotide sequence ID" value="XM_628451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYC7"/>
    <dbReference type="GeneID" id="3372271"/>
    <dbReference type="KEGG" id="cpv:cgd7_2860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2860"/>
    <dbReference type="InParanoid" id="Q5CYC7"/>
    <dbReference type="OMA" id="KESHINC"/>
    <dbReference type="OrthoDB" id="339249at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="33"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="144"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="204"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="825" mass="94669" checksum="BA7CC04257F4BFD1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYE5</accession>
    <name>Q5CYE5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TPR repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628435.1">
        <property type="nucleotide sequence ID" value="XM_628433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYE5"/>
    <dbReference type="STRING" id="353152.Q5CYE5"/>
    <dbReference type="GeneID" id="3371930"/>
    <dbReference type="KEGG" id="cpv:cgd7_2640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2640"/>
    <dbReference type="InParanoid" id="Q5CYE5"/>
    <dbReference type="OMA" id="ETYMTDL"/>
    <dbReference type="OrthoDB" id="1914839at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd24142">
        <property type="entry name" value="ACL4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14559">
        <property type="entry name" value="TPR_19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="39"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="319" mass="37057" checksum="350AD3C5A91D0F2E" modified="2005-04-12" version="1">MKTLELLSKAQALVNKFPPEYENANALFTQAIKLDPLNSNVLSAYGEFMCSIGNFESARELLEKSIKVNPYDDYVKYFSLAQILDGEESLSYWNNGIEVLQESIKIVEKKGNDKSCIERLDLMKNQLCSAYCAISELFMTDLCYSDEAESQVKENLAKASEIDDEHFETLCCKLAYFKTIDDFEECKKYVFKIKYILANKYNLSVEFNDFADELRNKDIILPEYSVRLNLSRTLIDLNETELAELVLSTLLKEDEEDWQIWYLLSWCSLVSEDVSGAIECFEMFEKYGNKHIQDIEFKQQFMSDLENLKLNIEKIKTCK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYZ4</accession>
    <name>Q5CYZ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-type ATpase 3 integral membrane protein with signal peptide and 12 or more transmembrane domains possible MgtA, cation tranport ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd7_460</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628236.1">
        <property type="nucleotide sequence ID" value="XM_628234.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYZ4"/>
    <dbReference type="TCDB" id="3.A.3.10.5">
        <property type="family name" value="the p-type atpase (p-atpase) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="3371909"/>
    <dbReference type="KEGG" id="cpv:cgd7_460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_460"/>
    <dbReference type="InParanoid" id="Q5CYZ4"/>
    <dbReference type="OMA" id="AKVNICA"/>
    <dbReference type="OrthoDB" id="289856at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF11">
        <property type="entry name" value="CATION-TRANSPORTING P-TYPE ATPASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="20"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="110"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="288"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="494"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="521"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1050"/>
            <end position="1069"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1081"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1118"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1174"/>
            <end position="1191"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1203"/>
            <end position="1221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1259"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="11">
        <location>
            <begin position="353"/>
            <end position="478"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1291" mass="146507" checksum="3C7C0DB4FFFCAB31" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ09</accession>
    <name>Q5CZ09_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RAD21-N-terminal like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628221.1">
        <property type="nucleotide sequence ID" value="XM_628219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ09"/>
    <dbReference type="STRING" id="353152.Q5CZ09"/>
    <dbReference type="GeneID" id="3371898"/>
    <dbReference type="KEGG" id="cpv:cgd7_290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_290"/>
    <dbReference type="InParanoid" id="Q5CZ09"/>
    <dbReference type="OMA" id="HKWHPHT"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990414">
        <property type="term" value="P:replication-born double-strand break repair via sister chromatid exchange"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039781">
        <property type="entry name" value="Rad21/Rec8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006910">
        <property type="entry name" value="Rad21_Rec8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585:SF69">
        <property type="entry name" value="FI11703P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12585">
        <property type="entry name" value="SCC1 / RAD21 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04825">
        <property type="entry name" value="Rad21_Rec8_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein N-terminal" evidence="6">
        <location>
            <begin position="23"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="5">
        <location>
            <begin position="593"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="110"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="110"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="646" mass="72979" checksum="C1A5496701A77E9A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ20</accession>
    <name>Q5CZ20_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628210.1">
        <property type="nucleotide sequence ID" value="XM_628208.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ20"/>
    <dbReference type="GeneID" id="3372034"/>
    <dbReference type="KEGG" id="cpv:cgd7_150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_150"/>
    <dbReference type="InParanoid" id="Q5CZ20"/>
    <dbReference type="OMA" id="ICILNDN"/>
    <dbReference type="OrthoDB" id="340342at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="197"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="220" mass="25925" checksum="BF201C35C5D9EF44" modified="2005-04-12" version="1">MKKVKYCLLIYILLFEIIYGWLLNFDIVPNSISEKNDISLENCRLNYWTQHNTECMDGCSMLGELRYGPNYLSSNALQELPNSIGINCRIQSFGTLFGKKLQKEDYWIKMDVCTSMIQSLADFVITELKYDSRKFFENSIPINNNKNMINSAYIGAYHMNSIGNIIRYKYTFYKYVKYSLIIDLILICLFVINSLIYKYRLVKINRIREQCKTSMKQADK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ25</accession>
    <name>Q5CZ25_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GPN-loop GTPase 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_80</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Binds to RNA polymerase II (RNAPII).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628205.1">
        <property type="nucleotide sequence ID" value="XM_628203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ25"/>
    <dbReference type="FunCoup" id="Q5CZ25">
        <property type="interactions" value="442"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CZ25"/>
    <dbReference type="GeneID" id="3372031"/>
    <dbReference type="KEGG" id="cpv:cgd7_80"/>
    <dbReference type="InParanoid" id="Q5CZ25"/>
    <dbReference type="OMA" id="MWFGQLI"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17871">
        <property type="entry name" value="GPN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000338">
        <property type="entry name" value="GPN-loop GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030231">
        <property type="entry name" value="Gpn2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF3">
        <property type="entry name" value="GPN-LOOP GTPASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="264" mass="30011" checksum="7D5F95242A3C5E44" modified="2005-04-12" version="1">MTLFGQVLIGPPGSGKTTFVHGMHQMCTALNRPNIIVNLDPANENVPYIPDVDVRDLINFENVMNEHKLGPNGALVYCMEYLQVNIDWLIDGIRAKRKNSSYILIDIPGQVELYTHNYVLREILSVLAKDLDTRLTAVHLIDSTLLSSPTNYISALLVSLSAQMSIELPYLNVFSKIDLLEHFKDDLPFKLEYFSQLEDLNQLLTFWKHESNMGDHPLFLKYKGFQSELVDLVEDSSIMQFIPVDINDKDSVLQILQLIDKSNG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPM9</accession>
    <name>A3FPM9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CMP/dCMP-type deaminase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_1470</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidine and deoxycytidylate deaminase family. ADAT3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388375.1">
        <property type="nucleotide sequence ID" value="XM_001388338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPM9"/>
    <dbReference type="FunCoup" id="A3FPM9">
        <property type="interactions" value="69"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPM9"/>
    <dbReference type="GeneID" id="3371781"/>
    <dbReference type="KEGG" id="cpv:cgd7_1470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1470"/>
    <dbReference type="InParanoid" id="A3FPM9"/>
    <dbReference type="OMA" id="FMCAMAM"/>
    <dbReference type="OrthoDB" id="3180714at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052717">
        <property type="term" value="F:tRNA-specific adenosine-34 deaminase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002125">
        <property type="entry name" value="CMP_dCMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016193">
        <property type="entry name" value="Cytidine_deaminase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079">
        <property type="entry name" value="CYTOSINE DEAMINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11079:SF156">
        <property type="entry name" value="INACTIVE TRNA-SPECIFIC ADENOSINE DEAMINASE-LIKE PROTEIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00383">
        <property type="entry name" value="dCMP_cyt_deam_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53927">
        <property type="entry name" value="Cytidine deaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51747">
        <property type="entry name" value="CYT_DCMP_DEAMINASES_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="CMP/dCMP-type deaminase" evidence="3">
        <location>
            <begin position="157"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="344" mass="39856" checksum="64ED6A88A2F8B310" modified="2007-04-03" version="1">MSNKDENDGSVLYEEVLPDSFYDDPEFMKFYSLKLPMKLANEFSRFVNNDQFTKRFPHIKRMRKVVIKENDLELRNFSSSSNDIRVEILIGETQECLPVEADNYLKENHIDKIWNVIEVPKNPPLTREKFSQLSKIWPLSFLKPRFTPEVLSDQVQHESDKFVKLACKVGEFAQSIGNPPRGCVITLKGKIVAIGEDNRNSDYPWMHSVMKAVDNFSKRVCSSSLSMPKMTNLLDSKIQDENQGSQNNEDHKDHLIEIKSKYNISEDQILSDSELKDQYLCTNGIAYLSHEPCISCSMALVHSRISKVFYMHKDKERGFLGSNHKLHCVSELNHHYRVFRANID</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPN5</accession>
    <name>A3FPN5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor SLU7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_1750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Involved in pre-mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Associated with the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the SLU7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388381.1">
        <property type="nucleotide sequence ID" value="XM_001388344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPN5"/>
    <dbReference type="FunCoup" id="A3FPN5">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPN5"/>
    <dbReference type="GeneID" id="3371823"/>
    <dbReference type="KEGG" id="cpv:cgd7_1750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1750"/>
    <dbReference type="InParanoid" id="A3FPN5"/>
    <dbReference type="OMA" id="RPATWGT"/>
    <dbReference type="OrthoDB" id="249612at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030628">
        <property type="term" value="F:pre-mRNA 3'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021715">
        <property type="entry name" value="Slu7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039974">
        <property type="entry name" value="Splicing_factor_SLU7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942:SF2">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12942">
        <property type="entry name" value="STEP II SPLICING FACTOR SLU7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11708">
        <property type="entry name" value="Slu7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA-splicing factor SLU7" evidence="9">
        <location>
            <begin position="130"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="168"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367071"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF11708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="405" mass="46825" checksum="CC047CF9D8408FC2" modified="2007-04-03" version="1">MNLDERDDSATEEIGRDDVRGANTTSDDALNPHIPQFIAKAPWYINQQESSLEHQRLRADEARIDLDSGIKKGVLGEAHVKYRKGACTNCGSMTHQARDCLERPRKVGAKWNNLDICPDEIIPEIRKTTNLDEKRDRWRGFRPEDYKPIIEQFEAVEELARQKRAKKVEESLSNNKNNPEDKNEELDEKDELKLGDFDETTFGASSDKTRTNVRNLRIREDTAKYLRNLDLNSAFYDPKSRSMREDPFHKSSNIGNTYRGDNAIRNSGEVSKILLMEAFAYNKHKQGESIHLQALPTRSEMLYKSSISNKDNDNLKKLEEISRKYERNNQPSISKLELTERPTTVGDLSSMNTKTTKKFVSSIYVEDEYISNHTQVWGSYYDLEAKKWGFRCCKQTCRFSKCTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPN8</accession>
    <name>A3FPN8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transmembrane protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd7_2150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Membrane</location>
            <topology evidence="1 7">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the EMP24/GP25L family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388384.1">
        <property type="nucleotide sequence ID" value="XM_001388347.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPN8"/>
    <dbReference type="FunCoup" id="A3FPN8">
        <property type="interactions" value="146"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPN8"/>
    <dbReference type="GeneID" id="3371826"/>
    <dbReference type="KEGG" id="cpv:cgd7_2150"/>
    <dbReference type="InParanoid" id="A3FPN8"/>
    <dbReference type="OMA" id="YYICISC"/>
    <dbReference type="OrthoDB" id="3427at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015720">
        <property type="entry name" value="Emp24-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009038">
        <property type="entry name" value="GOLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22811">
        <property type="entry name" value="TRANSMEMBRANE EMP24 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01105">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01190">
        <property type="entry name" value="EMP24_GP25L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50866">
        <property type="entry name" value="GOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002652585" evidence="9">
        <location>
            <begin position="18"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="domain" description="GOLD" evidence="10">
        <location>
            <begin position="27"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="207" mass="24067" checksum="F2E313CDDBF756EE" modified="2007-04-03" version="1" fragment="single">QAIILFLIIKCIRVYSAIYFYVQEGTEKCFIQEVPKSVPIHVKYENVNNLGIDCTVIFKNTENIEVFSRHVNENDHKGSVAYLPEVDGDHKVCIRCDSSNWFKSEQMKWILSIDTGNISEHLDVDSIASKDEANYVEEFINSLISKVNNQVSEGEYEFEKQEMFLKQALSVNKRIVIYSIIQLTLVSVISYFSIIHMRNFLRKQRII</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ11</accession>
    <name>A3FQ11_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_5180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388452.1">
        <property type="nucleotide sequence ID" value="XM_001388415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ11"/>
    <dbReference type="STRING" id="353152.A3FQ11"/>
    <dbReference type="GeneID" id="3374366"/>
    <dbReference type="KEGG" id="cpv:cgd8_5180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5180"/>
    <dbReference type="InParanoid" id="A3FQ11"/>
    <dbReference type="OMA" id="PEIIMGH"/>
    <dbReference type="OrthoDB" id="3967at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050494">
        <property type="entry name" value="Ser_Thr_dual-spec_kinase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24058:SF103">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE PRP4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="142"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="454" mass="52263" checksum="900C0DDD958FFCB6" modified="2007-04-03" version="1">MRRSSFSRSPSPEVRSPMDSLKKESISEITSLTKADQENKILIVETKEQKNSLINEPVLASSQDNLECKDEIKQEIMKKDNKIEQNIDFEEIDDIFASDTEESKSKYIKPSGNPGYNKRLECDDDDGYYVSYIGEIIGNRYKVSSNSTGKGMFSSVVKCVDMETQNEVAIKIIRINDMMRSTGEKEYSFVKKFKGAPNIVQVQGTFMHQNHLCIVFEWLHGSLKNCIHHFSKHNIRKTQDLAFQIFQGLKIIHEKGLVHADLKPENILIDSERKTIRISDFGSMHFTTDASPACYLVSRFYRAPEIILGCISYGQPIDIWSIGCVLYECFTGDIMFKGRTNNDMIKLIMEYRGNFPKRLLNQGVFTKSHFSECLTQFKWINTQGMLQIIKNYTANKNIYNNLMDSVKSSNIVYSETEQTLIRRLSNLIEKCLIIDPKKRISAKEALEHSFFQLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ30</accession>
    <name>A3FQ30_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd3_2330</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388110.1">
        <property type="nucleotide sequence ID" value="XM_001388073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ30"/>
    <dbReference type="STRING" id="353152.A3FQ30"/>
    <dbReference type="GeneID" id="3374078"/>
    <dbReference type="KEGG" id="cpv:cgd3_2330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2330"/>
    <dbReference type="InParanoid" id="A3FQ30"/>
    <dbReference type="OMA" id="KYHILFF"/>
    <dbReference type="OrthoDB" id="10261375at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17959">
        <property type="entry name" value="DEADc_DDX54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012541">
        <property type="entry name" value="DBP10_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033517">
        <property type="entry name" value="DDX54/DBP10_DEAD-box_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF8">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01123">
        <property type="entry name" value="DBP10CT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="13">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="11">
        <location>
            <begin position="35"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="12">
        <location>
            <begin position="232"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="815"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="9">
        <location>
            <begin position="4"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAZ51438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="862" mass="97698" checksum="9DD4B7D10257447F" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ35</accession>
    <name>A3FQ35_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Trafficking protein particle complex subunit 6B, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388115.1">
        <property type="nucleotide sequence ID" value="XM_001388078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ35"/>
    <dbReference type="STRING" id="353152.A3FQ35"/>
    <dbReference type="GeneID" id="3374072"/>
    <dbReference type="KEGG" id="cpv:cgd3_2700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2700"/>
    <dbReference type="InParanoid" id="A3FQ35"/>
    <dbReference type="OMA" id="CKEFWTA"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005801">
        <property type="term" value="C:cis-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14944">
        <property type="entry name" value="TRAPPC6A_Trs33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037992">
        <property type="entry name" value="TRAPPC6/Trs33"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817:SF0">
        <property type="entry name" value="GEO08327P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12817">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="210" mass="24168" checksum="BED78663C00D6F26" modified="2007-04-03" version="1" fragment="single">MEENNQISLSLLTFLRYEYLNYCINKSSELISDEKNFQTVKHSKKLSISGLQVCKDSLIRELSMSTLEESGFYLGIRLVERLSVFRHRIYDQKEIIKFICKDLWNFIFLKQADRLKTNRRGGYAILDNELIWLSKLPSSISANSRKVQFEPAINVIIVCGIIRGALQHLGLTCSVAAEVSKIPSCKLLSRIFYFNSVLGTFQIRVYAPSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ54</accession>
    <name>A3FQ54_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleoprotein TPR</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388190.1">
        <property type="nucleotide sequence ID" value="XM_001388153.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ54"/>
    <dbReference type="GeneID" id="3373429"/>
    <dbReference type="KEGG" id="cpv:cgd2_680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_680"/>
    <dbReference type="InParanoid" id="A3FQ54"/>
    <dbReference type="OMA" id="FFWNDQR"/>
    <dbReference type="OrthoDB" id="343070at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051241">
        <property type="entry name" value="DZIP_RILPL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502:SF3">
        <property type="entry name" value="CILIUM ASSEMBLY PROTEIN DZIP1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21502">
        <property type="entry name" value="ZINC FINGER PROTEIN DZIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="902"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1460"/>
            <end position="1517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1551"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1621"/>
            <end position="1646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1672"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="35"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="196"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="361"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="581"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="702"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="815"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="953"/>
            <end position="1005"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1034"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1222"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="908"/>
            <end position="927"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1460"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1487"/>
            <end position="1514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="1552"/>
            <end position="1568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1578"/>
            <end position="1593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="3">
        <location>
            <begin position="1675"/>
            <end position="1695"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1696"/>
            <end position="1716"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1717"/>
            <end position="1736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1770"/>
            <end position="1786"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1786" mass="204014" checksum="9600E2F9194E1A99" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQE2</accession>
    <name>A3FQE2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNAJ</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388164.1">
        <property type="nucleotide sequence ID" value="XM_001388127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQE2"/>
    <dbReference type="SMR" id="A3FQE2"/>
    <dbReference type="STRING" id="353152.A3FQE2"/>
    <dbReference type="GeneID" id="3371406"/>
    <dbReference type="KEGG" id="cpv:cgd1_2280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2280"/>
    <dbReference type="InParanoid" id="A3FQE2"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052763">
        <property type="entry name" value="DnaJ_C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44825:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="10"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="185" mass="21963" checksum="ED66B3513F883BEC" modified="2007-04-03" version="1">MDSVFYRFQTAFKLLGLEVGASTKEIKSSFRSLAKKVHPDKNRGKHEKSAHESFTKLRDSYVLLCNEIERRRFEKAYWSLNDSNTLQQKGRQDSYSNRSLTVNTSKTDGLLKKEKRDRMDLESLRRESIHLVNAFKDYFEAKVVKEYKKNKRNLRWALNHARVDKIIDRFSEFEKIVLFKLAHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQP9</accession>
    <name>A3FQP9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA mismatch repair protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the post-replicative DNA mismatch repair system (MMR).</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAZ51223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388418.1">
        <property type="nucleotide sequence ID" value="XM_001388381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQP9"/>
    <dbReference type="FunCoup" id="A3FQP9">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQP9"/>
    <dbReference type="GeneID" id="3372481"/>
    <dbReference type="KEGG" id="cpv:cgd8_370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_370"/>
    <dbReference type="InParanoid" id="A3FQP9"/>
    <dbReference type="OMA" id="TPMMAQY"/>
    <dbReference type="OrthoDB" id="10252754at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1170.10">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007695">
        <property type="entry name" value="DNA_mismatch_repair_MutS-lik_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017261">
        <property type="entry name" value="DNA_mismatch_repair_MutS/MSH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016151">
        <property type="entry name" value="DNA_mismatch_repair_MutS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF148">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01624">
        <property type="entry name" value="MutS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037677">
        <property type="entry name" value="DNA_mis_repair_Msh6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55271">
        <property type="entry name" value="DNA repair protein MutS, domain I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5 6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="8">
        <location>
            <begin position="1084"/>
            <end position="1100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="157"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="7"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="36"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR037677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1242" mass="140775" checksum="14F6D1D98F9744EC" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPI2</accession>
    <name>Q5CPI2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625367.1">
        <property type="nucleotide sequence ID" value="XM_625367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPI2"/>
    <dbReference type="GeneID" id="3375647"/>
    <dbReference type="KEGG" id="cpv:cgd6_310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_310"/>
    <dbReference type="InParanoid" id="Q5CPI2"/>
    <dbReference type="OrthoDB" id="338964at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="325" mass="37534" checksum="9090869605991BFB" modified="2005-04-12" version="1">MNEIMLEEMTEQNIDNSGELSVSEISGVEYIFFTKNDEANIKFRLDKMSMDDKLLEEYLNDKKKIFMNEKILNIYQGGRVLVGIILKKEYKLCDIIFDLSNSEKQSVLSNFIWEGQYQVLVTKENNYLEIFNDGKEGNNLMNLDDGSYINLIGIYNLKSIECNLYIFQCSIIIKPQYWNDLLNFDILIKYHQNDMFENSILNDEINESCNEIGKNELNYGSPFGDLLVLNEFSDSKIYSYSLSKPIFIKVPIIISNYFLQESSQILFIEILNIGEISDSILIYDIFSHNLKLNGNSPLELPFTLGNNQSLGCSLIRVGGKKFLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPN6</accession>
    <name>Q5CPN6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">IMP4-like U3 small nucleolar ribonucleoprotein (snoRNP)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625385.1">
        <property type="nucleotide sequence ID" value="XM_625385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPN6"/>
    <dbReference type="FunCoup" id="Q5CPN6">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPN6"/>
    <dbReference type="GeneID" id="3372368"/>
    <dbReference type="KEGG" id="cpv:cgd2_160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_160"/>
    <dbReference type="InParanoid" id="Q5CPN6"/>
    <dbReference type="OMA" id="AWIISNK"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF3">
        <property type="entry name" value="RIBOSOME PRODUCTION FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Brix" evidence="2">
        <location>
            <begin position="132"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="359" mass="42520" checksum="992C05C7F126F149" modified="2005-04-12" version="1">MSNKEKKQISDKNTANKKNASKSSKNVKDKVDKETELANKEIDLKNIKNKIKRAELANQLKREKKLEKSKRRRENREKEKRGEEVVKGIPRTIENTREIDETFVHDPLNDKELHKEMENDEFSDYFSRKRSPKLLITTNNKASKHMYNFLKEIVSIIPNCDFYKRNGFNIKDIIKEVNEKGTENNYTDILIFTEHPIKKIPWGLYICHLPIGPTSYFRIRSVKLAQDMKGSAFSTTHNPEVILNNFDTRIGYRIGRQLASLFPFNPDFAGRRVIAFHNQRDFIFFRHYRYIFRKKRTTSTQNAEEQQDQAINSAGLQEIGPRFTLKLMWIQEGTFNTKKGIYEYLWRPDLQVNRKVFFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPS3</accession>
    <name>Q5CPS3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_4260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625441.1">
        <property type="nucleotide sequence ID" value="XM_625441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPS3"/>
    <dbReference type="GeneID" id="3372395"/>
    <dbReference type="KEGG" id="cpv:cgd4_4260"/>
    <dbReference type="InParanoid" id="Q5CPS3"/>
    <dbReference type="OrthoDB" id="338667at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="170" mass="19483" checksum="817F04F803526344" modified="2005-04-12" version="1">MGCCVSKDEGAVKNIKLKKKNNGLELSQKFVIRNHNGNRLLSFWDIITYEGINFGNKAHNLSTEFIQPQIKELHAIWIISILRQLRSEVDTIFLLSRLIEITELLDPLDGNSIIRNHMCESGAVEILLNTIKYHKKSPEIVLICIFLLTHLFFNDGVSERMVPIVSLRNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPT8</accession>
    <name>Q5CPT8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_4070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625426.1">
        <property type="nucleotide sequence ID" value="XM_625426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPT8"/>
    <dbReference type="GeneID" id="3372419"/>
    <dbReference type="KEGG" id="cpv:cgd4_4070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4070"/>
    <dbReference type="InParanoid" id="Q5CPT8"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="104" mass="12972" checksum="599396119B789512" modified="2005-04-12" version="1">MSNIFSSLLFYFPPPHTLLSFYFSNIYSIYYFNAISIFYFLFYFNPQNSTQTLFFCYLFNLKKKRRKLHLLSRNIFIVTFNAYLYLIYNYYVLDIPFNYYTYMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQA9</accession>
    <name>Q5CQA9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TAP42-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625739.1">
        <property type="nucleotide sequence ID" value="XM_625739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQA9"/>
    <dbReference type="FunCoup" id="Q5CQA9">
        <property type="interactions" value="122"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQA9"/>
    <dbReference type="GeneID" id="3372636"/>
    <dbReference type="KEGG" id="cpv:cgd4_1430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1430"/>
    <dbReference type="InParanoid" id="Q5CQA9"/>
    <dbReference type="OMA" id="KDTHPWG"/>
    <dbReference type="OrthoDB" id="10261753at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051721">
        <property type="term" value="F:protein phosphatase 2A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035303">
        <property type="term" value="P:regulation of dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.540">
        <property type="entry name" value="TAP42-like family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038511">
        <property type="entry name" value="TAP42/TAP46-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007304">
        <property type="entry name" value="TAP46-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10933:SF9">
        <property type="entry name" value="IMMUNOGLOBULIN-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04177">
        <property type="entry name" value="TAP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="324"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="332"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="379" mass="44710" checksum="B15AB5021B7BDAC8" modified="2005-04-12" version="1">MDFHQISEKFLNLLKRYYKEIYDDFSESDLDEIIKLRDEILDFGNEIDFSNIISKNEEVEDLNTNDIKYLLYSYIKAETTRYVRDHNVPKERVERRNDLNEIMELYLQFFNNTLEIRNTIFKDTLDLVDNSQIKNLFIEESEKKIIKDTRQIKIMRFKKIKELKSSLSLFFKSGFNLTDESENRDMILKAINLFFLESIEQVSMINNEINILNYAIKEEFTKTSENGDKRYGDNNINNINNKIQKNCPPLNIKHIAPNIRYLTSKENTSNTGFTFKDINNGTAGVVINDRENFYSKVFGPSHTLPTISIAEAADMELKEALEQEKSSNIARKNKEERDQILHDKEYSKEEEEDELKARSWDDWKDLNPKGHGNTIRNRG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQC8</accession>
    <name>Q5CQC8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L28</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd4_1230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625720.1">
        <property type="nucleotide sequence ID" value="XM_625720.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQC8"/>
    <dbReference type="STRING" id="353152.Q5CQC8"/>
    <dbReference type="GeneID" id="3372649"/>
    <dbReference type="KEGG" id="cpv:cgd4_1230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1230"/>
    <dbReference type="InParanoid" id="Q5CQC8"/>
    <dbReference type="OMA" id="CSRAMRK"/>
    <dbReference type="OrthoDB" id="338850at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002672">
        <property type="entry name" value="Ribosomal_eL28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10544">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="4">
        <location>
            <begin position="6"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="127" mass="14415" checksum="367D4C0E7B71D8D8" modified="2005-04-12" version="1">MFSTELLWQCVKKNTSFIKKNNGFTFTSEPFNIMNLNTLKYSGLAARRSISMDLVPNSNGKLVKNAKITKKNTGSSTIRCPKKLISKVNLSNNFKQAKKTIKNQISSRPDLKNVAIIRYRKIQKAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQH6</accession>
    <name>Q5CQH6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625672.1">
        <property type="nucleotide sequence ID" value="XM_625672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQH6"/>
    <dbReference type="GeneID" id="3372748"/>
    <dbReference type="KEGG" id="cpv:cgd4_680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_680"/>
    <dbReference type="InParanoid" id="Q5CQH6"/>
    <dbReference type="OMA" id="NIDTNGM"/>
    <dbReference type="OrthoDB" id="340190at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="372"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="653"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="680"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="680" mass="74529" checksum="E4A57A42ABC09A88" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQI8</accession>
    <name>Q5CQI8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625660.1">
        <property type="nucleotide sequence ID" value="XM_625660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQI8"/>
    <dbReference type="GeneID" id="3372757"/>
    <dbReference type="KEGG" id="cpv:cgd4_550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_550"/>
    <dbReference type="InParanoid" id="Q5CQI8"/>
    <dbReference type="OMA" id="CKMSTIN"/>
    <dbReference type="OrthoDB" id="341553at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="315"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="363" mass="41994" checksum="83EE3C4E52DEB54B" modified="2005-04-12" version="1">MQSQRNYAKQELIYDLLFGNNKRKLPKGGIWNFEDSNECVICKRDKFGVATGLGTELPNVIPELLCIECKRGLFSFEGFRYQCKQVKNSVSNLESISVVLNEQIRKLYNLIGKERNFSGSSKKIEQNKVPDWCNRDIPSKFGKGNFKFEEGIEQIKKDITHNEESRLSDQLELFHEDLINLQETIFTFINVLEAYIDTPWTSVLKEAKYKQETQPCVTSFNEDNIITPVESVKTQVITNQNQESNTTAQRIERIRRQQEKVRQQIKALYDNNTTDLPENNGSHYFSSVDTETNNFNKDSIGNYFLFSRDILQSDKDDDEDRANEDRKNMNSKEIGEQSQHVLRNYDILWSPSSASASSNIDSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQQ2</accession>
    <name>Q5CQQ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ydr140wp-like HemK family methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_3740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic/archaeal PrmC-related family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625950.1">
        <property type="nucleotide sequence ID" value="XM_625950.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQQ2"/>
    <dbReference type="FunCoup" id="Q5CQQ2">
        <property type="interactions" value="88"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQQ2"/>
    <dbReference type="GeneID" id="3372803"/>
    <dbReference type="KEGG" id="cpv:cgd4_3740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3740"/>
    <dbReference type="InParanoid" id="Q5CQQ2"/>
    <dbReference type="OMA" id="EWDDWME"/>
    <dbReference type="OrthoDB" id="406152at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035657">
        <property type="term" value="C:eRF1 methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008276">
        <property type="term" value="F:protein methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002052">
        <property type="entry name" value="DNA_methylase_N6_adenine_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052190">
        <property type="entry name" value="Euk-Arch_PrmC-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007848">
        <property type="entry name" value="Small_mtfrase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45875:SF1">
        <property type="entry name" value="METHYLTRANSFERASE N6AMT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05175">
        <property type="entry name" value="MTS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00092">
        <property type="entry name" value="N6_MTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase small" evidence="5">
        <location>
            <begin position="40"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="254" mass="29081" checksum="2529A59C3F07A9C2" modified="2005-04-12" version="1">MIDLSFTKKSDWENVYEPSEDSFLMEDALILEKNEILKAKPRLICEIGCGSGYLTACLLKIIKESDAEFSLPISYLVDVNTKALEMSEKVISNNKINSPIELIKMSLFTCLNRNRGLFEIIIFNPPYVPSSNKELNQSILNCGIDSAWSGGVNGLFFVSYFLFGDNRLILSETSHQFQEEEIIRIEDQFNSFPSLVDVLAPKGVCYLLLEENNCPKFTLEQILKEPRYSGWNVQFIIDRKVQLEHLYILKLTPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQR3</accession>
    <name>Q5CQR3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_3630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87763.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625939.1">
        <property type="nucleotide sequence ID" value="XM_625939.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQR3"/>
    <dbReference type="STRING" id="353152.Q5CQR3"/>
    <dbReference type="GeneID" id="3372810"/>
    <dbReference type="KEGG" id="cpv:cgd4_3630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3630"/>
    <dbReference type="InParanoid" id="Q5CQR3"/>
    <dbReference type="OMA" id="GTEQGSY"/>
    <dbReference type="OrthoDB" id="344367at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254127" evidence="3">
        <location>
            <begin position="22"/>
            <end position="967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="46"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="154"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="738"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="919"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="46"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="67"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="160"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="190"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="241"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="282"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="331"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="352"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="371"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="400"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="465"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="505"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="531"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="558"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="629"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="643"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="760"/>
            <end position="789"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87763.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="967" mass="95559" checksum="C5D8C001D8744318" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQR9</accession>
    <name>Q5CQR9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_3570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625933.1">
        <property type="nucleotide sequence ID" value="XM_625933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQR9"/>
    <dbReference type="GeneID" id="3372814"/>
    <dbReference type="KEGG" id="cpv:cgd4_3570"/>
    <dbReference type="InParanoid" id="Q5CQR9"/>
    <dbReference type="OrthoDB" id="343213at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="770" mass="90963" checksum="6582BEDD70DC4FCA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQT9</accession>
    <name>Q5CQT9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_3360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87920.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625913.1">
        <property type="nucleotide sequence ID" value="XM_625913.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQT9"/>
    <dbReference type="FunCoup" id="Q5CQT9">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQT9"/>
    <dbReference type="GeneID" id="3372936"/>
    <dbReference type="KEGG" id="cpv:cgd4_3360"/>
    <dbReference type="InParanoid" id="Q5CQT9"/>
    <dbReference type="OMA" id="RHWKPNA"/>
    <dbReference type="OrthoDB" id="2161379at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051972">
        <property type="entry name" value="Glutamate-rich_WD_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45903:SF1">
        <property type="entry name" value="GLUTAMATE-RICH WD REPEAT-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="88"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="353"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="397"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="158"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87920.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="500" mass="56758" checksum="4082C628E8D667CD" modified="2005-04-12" version="1" fragment="single">GRKHLEVEEDELPSKFTPSKPKSEMYEKQEAMMNVEGEFAEEMDDEIESEEEVIREETEDGSEIVEGADEDVEIEEHYWLPGQGDENQELVYEPKAYKMYHKCLVEWSCLTLDILPDKLGDNRTQFPHTCYVVAGTQANMEDNNHILLMKWSRMHKTKRDRDENDNSDSDLSDSDDSDDDNFADEDPIVNVAAIPHKGTINRIRVCPQLPNLVSTWSELGKVCMWDITESINNLNTDHLNSKTLKPSNLAKKSTTKPKFSYDGHLDEGFSMDWNPNQIAQFASGDRKGNICFWQPIQGGSWSVNPVHGNFQSSVEAIQWKRDSNSSSIFAAGLVNSNICIVDIRSESDQLTIENSHNGDVNCISWNPFSENLLLSGSDDATIKLWDIRSTKDPLETFIFHREPILSVDWHHQDQDVFLAASLDNSISFWDIAIDDEVIDEDNSDSKTDATLSGTPNIPKKLLFLHMGQEHIAEAKWHKQIPSLTISTAQDSFNVFIPSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQY1</accession>
    <name>Q5CQY1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10 11">Tubulin alpha chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd4_2860</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 11">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subunit">
        <text evidence="2 11">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 11">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625871.1">
        <property type="nucleotide sequence ID" value="XM_625871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQY1"/>
    <dbReference type="SMR" id="Q5CQY1"/>
    <dbReference type="FunCoup" id="Q5CQY1">
        <property type="interactions" value="62"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQY1"/>
    <dbReference type="GeneID" id="3372973"/>
    <dbReference type="KEGG" id="cpv:cgd4_2860"/>
    <dbReference type="InParanoid" id="Q5CQY1"/>
    <dbReference type="OMA" id="YMASCIL"/>
    <dbReference type="OrthoDB" id="6049624at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02186">
        <property type="entry name" value="alpha_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000005">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000001">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000004">
        <property type="entry name" value="Tubulin alpha chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002452">
        <property type="entry name" value="Alpha_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01162">
        <property type="entry name" value="ALPHATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="13">
        <location>
            <begin position="55"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="14">
        <location>
            <begin position="254"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="424"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00071544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK87929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="459" mass="51023" checksum="9DAEBB14BF7FF48A" modified="2005-04-12" version="1" fragment="single">SYSLNMREVISIHVGQAGIQIGNACWELFCLEHGINPDGTMPMSEQNMGISDDAFNTFFSETGAGKHVPRAVFVDLEPTVVDEIRSGTYRQLFHPEQLINGKEDAANNFARGHYTVGKEILEVCLDRIRKLADNCTGLQGFLMFNAVGGGTGAGLGTLLLERLSVDYGKKSKLNFCTWPSPQLSTAVVEPYNAVLSTHSLLEHADVAVMLDNEAIYDICRRNLNIEQPAYTNLNRLIAQVISSLTASLRFDGALNVDITEFQTNLVPYPRIHFMLSSYAPIISAEKAFHEQLSVAEITNAVFEPQNQMAKCDPRHGKYMACCLMYRGDVVPKDTNAAVATIKTKRTIQFVDWCPTGFKCGINYQPPTVVPGGDLAKVMRACCMISNSTAIAEVFNRMDHKFDLMYSKRAFVHWYVGEGMEEGEFSEAREDLAALEKDYEEVGIEIADGEDEEVHYEGDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR77</accession>
    <name>Q5CR77_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_1810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625775.1">
        <property type="nucleotide sequence ID" value="XM_625775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR77"/>
    <dbReference type="GeneID" id="3372905"/>
    <dbReference type="KEGG" id="cpv:cgd4_1810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1810"/>
    <dbReference type="InParanoid" id="Q5CR77"/>
    <dbReference type="OrthoDB" id="342813at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="117" mass="13911" checksum="4CA227F1EA957FE4" modified="2005-04-12" version="1">MILDFKLFYFISGDNSKYYIYTSINIFNSKEFFYEVCESKLHMKIEVVNNNRIFNWPIKPFQNWRSFTYITLIWVAWQLITPTVQGKYILIVVSTRVISAILAKFLSNILEKASFSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR99</accession>
    <name>Q5CR99_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd4_1570</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNU66/SART1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625753.1">
        <property type="nucleotide sequence ID" value="XM_625753.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR99"/>
    <dbReference type="FunCoup" id="Q5CR99">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR99"/>
    <dbReference type="GeneID" id="3372768"/>
    <dbReference type="KEGG" id="cpv:cgd4_1570"/>
    <dbReference type="InParanoid" id="Q5CR99"/>
    <dbReference type="OMA" id="LCWKFHG"/>
    <dbReference type="OrthoDB" id="5583at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000481">
        <property type="term" value="P:maturation of 5S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005011">
        <property type="entry name" value="SNU66/SART1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152">
        <property type="entry name" value="SQUAMOUS CELL CARCINOMA ANTIGEN RECOGNISED BY CYTOTOXIC T LYMPHOCYTES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14152:SF5">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03343">
        <property type="entry name" value="SART-1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="265"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="323"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="407" mass="47453" checksum="2D7E846D18086DD5" modified="2005-04-12" version="1" fragment="single">KFIFKKKINSYFIKPYYVIKQLEGIEEGGGSNMSESDRMPDQFKQGKIITFEDKHILEYKDDEDDCDQLNAKIHLNKINLGSENNRKNDDFRENKSQDKFKFKRTKIKVIKKNLRKETNFELANDEEKNSSSSVNNNDIDNNTELTNFNTNFLTNSNSIFDDTDIFYNRLKIQKKRKTLENTKNEFEFQYNNKLNSTNEENINNSESSIYLSLETEFCRKIDNSSTNDQINDSISNNAITKTEIESLYSNSLNKDNLNELQNTVLKQESSNDNNRQKTSKNTEETRVSDEKTQNNLNNNILYEEPLDFGISSTLELLKKRGNISSSNKKDPITSNNNEFGQKNENYSTDSALNSESDFQVSILHTDDNGNILNPKEAFKRLCWKFHGQKVNKNKIEKMLRNHLRNKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRB4</accession>
    <name>Q5CRB4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_3480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626272.1">
        <property type="nucleotide sequence ID" value="XM_626272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRB4"/>
    <dbReference type="GeneID" id="3373099"/>
    <dbReference type="KEGG" id="cpv:cgd5_3480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3480"/>
    <dbReference type="InParanoid" id="Q5CRB4"/>
    <dbReference type="OMA" id="ATIADNC"/>
    <dbReference type="OrthoDB" id="506431at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd03440">
        <property type="entry name" value="hot_dog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.129.10">
        <property type="entry name" value="Hotdog Thioesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029069">
        <property type="entry name" value="HotDog_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052061">
        <property type="entry name" value="PTE-AB_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006683">
        <property type="entry name" value="Thioestr_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47260:SF1">
        <property type="entry name" value="UPF0644 PROTEIN PB2B4.06"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03061">
        <property type="entry name" value="4HBT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54637">
        <property type="entry name" value="Thioesterase/thiol ester dehydrase-isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioesterase" evidence="2">
        <location>
            <begin position="110"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="208" mass="23097" checksum="6B75D8827DEC2BDC" modified="2005-04-12" version="1">MEKQATEHKLHHQSIPSTVSTSTDSIDIDSLSPKQVESDTWLDKILNEKGILDITNNILSLVNDENKLINTFNKNSCIISTKIYLSKQTEKPPSIISVIELGKNIESHSNVVHGGFSATLVDNCLGILAAQLYKFPVTKTLNLAYKKPILPGQTIVIISRVKDSEQENNESMIQSDRCTLISEIFNMNQDVLLSSEAVFVDISGRVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRE1</accession>
    <name>Q5CRE1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Histone H2B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd5_3170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 10">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 10">Belongs to the histone H2B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626245.1">
        <property type="nucleotide sequence ID" value="XM_626245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRE1"/>
    <dbReference type="FunCoup" id="Q5CRE1">
        <property type="interactions" value="51"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRE1"/>
    <dbReference type="GeneID" id="3373214"/>
    <dbReference type="KEGG" id="cpv:cgd5_3170"/>
    <dbReference type="InParanoid" id="Q5CRE1"/>
    <dbReference type="OMA" id="AQLCQTT"/>
    <dbReference type="OrthoDB" id="10036053at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22910">
        <property type="entry name" value="HFD_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000016">
        <property type="entry name" value="Histone H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000558">
        <property type="entry name" value="Histone_H2B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055333">
        <property type="entry name" value="HISTONE_H2B_site"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23428">
        <property type="entry name" value="HISTONE H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00621">
        <property type="entry name" value="HISTONEH2B"/>
    </dbReference>
    <dbReference type="SMART" id="SM00427">
        <property type="entry name" value="H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00357">
        <property type="entry name" value="HISTONE_H2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="9 10" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="11">
        <location>
            <begin position="49"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="152" mass="16813" checksum="A2024AAA31BD9BA8" modified="2005-04-12" version="1" fragment="single">GVDIKWISLQFQLCEKKGQSQSAVLHELGKLSTNSIKMAPKMSSKNNKGAAPKKIHKKKKESYSTYIYKVLKQVHPETGISKKSMMIMNSYISDTFEKIAQQAAQLCQTTKKDTIASREIQTAVRLVLPGELAKHAVSEGTKAVTKFTGGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRJ9</accession>
    <name>Q5CRJ9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd5_2500</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626187.1">
        <property type="nucleotide sequence ID" value="XM_626187.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRJ9"/>
    <dbReference type="GeneID" id="3373155"/>
    <dbReference type="KEGG" id="cpv:cgd5_2500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2500"/>
    <dbReference type="InParanoid" id="Q5CRJ9"/>
    <dbReference type="OMA" id="ESHTECT"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02668">
        <property type="entry name" value="Peptidase_C19L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033841">
        <property type="entry name" value="Pep_USP48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF722">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="141"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="365"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="589"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="905"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1063"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="639"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="184"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="590"/>
            <end position="599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="611"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="918"/>
            <end position="952"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1619" mass="184360" checksum="FC4847146D8475FE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRX9</accession>
    <name>Q5CRX9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_1060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626057.1">
        <property type="nucleotide sequence ID" value="XM_626057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRX9"/>
    <dbReference type="GeneID" id="3373076"/>
    <dbReference type="KEGG" id="cpv:cgd5_1060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1060"/>
    <dbReference type="InParanoid" id="Q5CRX9"/>
    <dbReference type="OrthoDB" id="341338at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="118"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="219" mass="25917" checksum="B00041A138F4ED86" modified="2005-04-12" version="1">MHTNLFINKRVSADNKNVNVQRLRNEKEKIKEWNENLTNLVTNINRRANNPTDKLINTNSRHNKYHDNSPKNIPFNGRLKGEQKKANEHLENKFNFTNQKNNKSNSLEDQYTLVLIEKQNIEESCNELKKRYNQLVLRFEEAIEQKESFREGLKNKINEYQKLQELHNGTQSLLAVGNKAQEELYQTQKQFQIILGKRNVEFSNVKDELEAKKTEFEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS20</accession>
    <name>Q5CS20_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF1279 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626016.1">
        <property type="nucleotide sequence ID" value="XM_626016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS20"/>
    <dbReference type="STRING" id="353152.Q5CS20"/>
    <dbReference type="GeneID" id="3373170"/>
    <dbReference type="KEGG" id="cpv:cgd5_590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_590"/>
    <dbReference type="InParanoid" id="Q5CS20"/>
    <dbReference type="OrthoDB" id="426386at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045866">
        <property type="entry name" value="FAM210A/B-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009688">
        <property type="entry name" value="FAM210A/B-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21377:SF0">
        <property type="entry name" value="PROTEIN FAM210B, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06916">
        <property type="entry name" value="FAM210A-B_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="115"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="DUF1279" evidence="2">
        <location>
            <begin position="107"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="208" mass="24420" checksum="D56436C6C0F200F2" modified="2005-04-12" version="1">MIFGNKLFFSSSTLKKVSKTINLTYKNSIFIPISSFCSSRLLFNSSSTFNQYFSPFRNDNSFKNLNYCLSGSQRLCPYYYHSLKNQFSKINISDLDKKFRLLDGFGKMKNLWNKYGYTSIFTYFTIYLATFISFWILAINNIINAAKLIKLISVLRLDNHINSSKIEQRMETPFGKLFIAWISTKIVEPFRLFSTITLTPYIYKILKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS22</accession>
    <name>Q5CS22_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626014.1">
        <property type="nucleotide sequence ID" value="XM_626014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS22"/>
    <dbReference type="GeneID" id="3373172"/>
    <dbReference type="KEGG" id="cpv:cgd5_570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_570"/>
    <dbReference type="InParanoid" id="Q5CS22"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="135" mass="16211" checksum="17F6D141E6056336" modified="2005-04-12" version="1">MIFKTKNQSKLTQKKSNTESNHGKCNNLIEISKDMDNSTYKKFINRKRNVSILLIVIIFLFFWFLIINKQELFSNLIFLKEKFNLLANKFNTSLKIFQNYHLFSFDENLTKTLIGKIYELFNNIYLTFEKCSNFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS38</accession>
    <name>Q5CS38_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Conserved protein with 2 transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625998.1">
        <property type="nucleotide sequence ID" value="XM_625998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS38"/>
    <dbReference type="FunCoup" id="Q5CS38">
        <property type="interactions" value="46"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS38"/>
    <dbReference type="GeneID" id="3373184"/>
    <dbReference type="KEGG" id="cpv:cgd5_360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_360"/>
    <dbReference type="InParanoid" id="Q5CS38"/>
    <dbReference type="OMA" id="WWTDTNV"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="398" mass="46752" checksum="CAECE5C287DFBCE1" modified="2005-04-12" version="1">MEINSGLRQRNNMEKLCDNEEKIFTNNELIYCSNEATINSNNESNLNNNNNNNVSSEYYSKISMKKEKERNEKNHFHLKNNKVINNIERWIPFYTPHYLILIYIFVGITFITVGIFLQIFSNNTIECIINYEDSPGNGKVIDTIVEIKSEHCNPSMINGNELKYLKGDFFIYYQLRNFYQNNKSFIFSRSDRQLSGELIYNEETLSDCYPVIKDKQGKIFYPCGVATLTIFNDTFTILDGQNDPIEIDDSIDTITFKSDQINYKNIPEHELLNHKFNDWLPKDIFPGRIENPHFIVWMKLSAFSTFNKIYGKLNSKKNKLILPLKIHVKNRYPVHFFNGSKHIVISQSTIFGGKNPYFGILYIISGILFILLSIYYIIRNKFNTNILGDFRFLYWNNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS52</accession>
    <name>Q5CS52_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LSM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625984.1">
        <property type="nucleotide sequence ID" value="XM_625984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS52"/>
    <dbReference type="GeneID" id="3373196"/>
    <dbReference type="KEGG" id="cpv:cgd5_200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_200"/>
    <dbReference type="InParanoid" id="Q5CS52"/>
    <dbReference type="OMA" id="NTRSYIK"/>
    <dbReference type="OrthoDB" id="342696at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="113" mass="13096" checksum="3A5FFAEA0A6D65FC" modified="2005-04-12" version="1">MELLLNSINYKIVIITLINGSTIQGTLEYRKIFLSKAQYKSIKNKRLKMIQLKNIVIIQESNKSPNFNANYNNINTLFIPIKSIHSLTCPEVENPSKHIRMYLKSSILLNMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSB7</accession>
    <name>Q5CSB7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Predicted AFG1 ATpase family AAA ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd1_3360</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">In the C-terminal section; belongs to the peptidase M41 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4">In the N-terminal section; belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628150.1">
        <property type="nucleotide sequence ID" value="XM_628150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSB7"/>
    <dbReference type="FunCoup" id="Q5CSB7">
        <property type="interactions" value="261"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSB7"/>
    <dbReference type="MEROPS" id="M41.A13"/>
    <dbReference type="GeneID" id="3371588"/>
    <dbReference type="KEGG" id="cpv:cgd1_3360"/>
    <dbReference type="InParanoid" id="Q5CSB7"/>
    <dbReference type="OMA" id="ARQKGNF"/>
    <dbReference type="OrthoDB" id="1413014at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005745">
        <property type="term" value="C:m-AAA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004176">
        <property type="term" value="F:ATP-dependent peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034982">
        <property type="term" value="P:mitochondrial protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19501">
        <property type="entry name" value="RecA-like_FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000019">
        <property type="entry name" value="AFG3-like AAA ATPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000001">
        <property type="entry name" value="ATP-dependent zinc metalloprotease FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1690.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.760">
        <property type="entry name" value="Peptidase M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01458">
        <property type="entry name" value="FtsH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050928">
        <property type="entry name" value="ATP-dep_Zn_Metalloprotease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005936">
        <property type="entry name" value="FtsH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000642">
        <property type="entry name" value="Peptidase_M41"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037219">
        <property type="entry name" value="Peptidase_M41-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01241">
        <property type="entry name" value="FtsH_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655:SF2">
        <property type="entry name" value="AFG3 LIKE MATRIX AAA PEPTIDASE SUBUNIT 2, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43655">
        <property type="entry name" value="ATP-DEPENDENT PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01434">
        <property type="entry name" value="Peptidase_M41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140990">
        <property type="entry name" value="FtsH protease domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="12" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="291"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00010550"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK88317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="719" mass="80474" checksum="DB2C65F876A7BA19" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSH6</accession>
    <name>Q5CSH6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">N-terminal acetyltransferase complex ard1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_2660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628091.1">
        <property type="nucleotide sequence ID" value="XM_628091.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSH6"/>
    <dbReference type="FunCoup" id="Q5CSH6">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSH6"/>
    <dbReference type="GeneID" id="3371351"/>
    <dbReference type="KEGG" id="cpv:cgd1_2660"/>
    <dbReference type="InParanoid" id="Q5CSH6"/>
    <dbReference type="OMA" id="EQHPSMR"/>
    <dbReference type="OrthoDB" id="10264728at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031416">
        <property type="term" value="C:NatB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004596">
        <property type="term" value="F:protein-N-terminal amino-acid acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051646">
        <property type="entry name" value="NatB_acetyltransferase_subunit"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45910:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="28"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="180" mass="20880" checksum="86D277DAB5447BB2" modified="2005-04-12" version="1" fragment="single">KFNISLFSSSLHCAFILSEFNMPQETALIYRPLKLSDIFKINKVNLDSFTETYNMNYYGDYLSTWPELCFVCEAPDHSIAGYLVSKVEGEGDQWHGHVTALSVSQQYRNSGVATKLMKFLEDISTQLNCHFIDLFVRPSNEKAVKFYKQLGYYVHQTIPSYYTDEDGYDMRKLICNKNLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSK1</accession>
    <name>Q5CSK1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein, Flx1p like mitochondrial membrane associated flavin transporter with 4 or more transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd1_2370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628066.1">
        <property type="nucleotide sequence ID" value="XM_628066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSK1"/>
    <dbReference type="STRING" id="353152.Q5CSK1"/>
    <dbReference type="GeneID" id="3371354"/>
    <dbReference type="KEGG" id="cpv:cgd1_2370"/>
    <dbReference type="InParanoid" id="Q5CSK1"/>
    <dbReference type="OMA" id="TTVWKHE"/>
    <dbReference type="OrthoDB" id="428293at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="76"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="190"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="10"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="124"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="230"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="329" mass="37668" checksum="9A2536FB72A138B0" modified="2005-04-12" version="1" fragment="single">AWHNNFMKKIKFFLTATSSLISAIITSFLLHPLDVVRTRQQVAAASDGAVIAHPTLISTINFIIDTEGVIGLYKGLNGQLVASGVSWFIFRYFFDFIRYFIEENKCFVFSYVVKSQTCFYPLQISPFSNSISTIIASVLSTALVHPLWLVKSRLEIQSVNTKKKGWKQYSAGLHGIAECMYSIYQKNGICGLYSGFIPTLMLIPHTLIQLVIYDIFRNQSINYNSKHLYLSNLRFFIFGFISKLLASALTYPLQVIRSRMQMAKIENIQLKTYDINILKLSHKEFVNFARDHYFPGLMTHIPKVSMHSGIMFLIYEAMIKLFESILSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSR2</accession>
    <name>Q5CSR2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_1650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628005.1">
        <property type="nucleotide sequence ID" value="XM_628005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSR2"/>
    <dbReference type="GeneID" id="3371642"/>
    <dbReference type="KEGG" id="cpv:cgd1_1650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1650"/>
    <dbReference type="InParanoid" id="Q5CSR2"/>
    <dbReference type="OMA" id="PLEWCSG"/>
    <dbReference type="OrthoDB" id="337100at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="133" mass="15105" checksum="AE44A6C77766CEC2" modified="2005-04-12" version="1">MENLIIMWSLMKSCCYSIGGSSCTDPVNFNADWCSLIHTNDEESKNFQYKLNSSKRDESSENQKKISMSSTDINDLVNYFIKCALNGVSVDIYDQASQSFVSGKYFINRNLNIITFKSPVHTIIIPFKAVSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSW3</accession>
    <name>Q5CSW3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_1090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627954.1">
        <property type="nucleotide sequence ID" value="XM_627954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSW3"/>
    <dbReference type="STRING" id="353152.Q5CSW3"/>
    <dbReference type="GeneID" id="3371550"/>
    <dbReference type="KEGG" id="cpv:cgd1_1090"/>
    <dbReference type="InParanoid" id="Q5CSW3"/>
    <dbReference type="OMA" id="IFRANTN"/>
    <dbReference type="OrthoDB" id="287623at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="766" mass="87964" checksum="E84DE93BCC2644CD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSZ4</accession>
    <name>Q5CSZ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glutamine cyclotransferase, predicted bacterial/plant origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627923.1">
        <property type="nucleotide sequence ID" value="XM_627923.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSZ4"/>
    <dbReference type="SMR" id="Q5CSZ4"/>
    <dbReference type="STRING" id="353152.Q5CSZ4"/>
    <dbReference type="GeneID" id="3371536"/>
    <dbReference type="KEGG" id="cpv:cgd1_730"/>
    <dbReference type="InParanoid" id="Q5CSZ4"/>
    <dbReference type="OMA" id="NDKLFQV"/>
    <dbReference type="OrthoDB" id="409395at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016603">
        <property type="term" value="F:glutaminyl-peptide cyclotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007788">
        <property type="entry name" value="QCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011044">
        <property type="entry name" value="Quino_amine_DH_bsu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31270:SF1">
        <property type="entry name" value="GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05096">
        <property type="entry name" value="Glu_cyclase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50969">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254216" evidence="1">
        <location>
            <begin position="22"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="345" mass="39820" checksum="C874EB12B92F3FD3" modified="2005-04-12" version="1">MFLLGLFLFSCLIIKWNFSLSQDSLHSVQLPNIYSVKILQEFPHYHIPENHIFSENDSSYKYNKNPFTQGLMFLNSTILIESAGLIEGSFIKLIEFPSMKNLQHKILPKRNWGEGIATLNGHIYQLTWTSRVMFGYSLDLSVVKRYSIPLTGWGLTSDNESRIWATSGSDQLFELNVPDFDSSDNKVTIKKVIMLRCLGKPMHFVNEMEYIPETKTIWGNIFQSQMIVEFSPETGECISIANLKSIYDPSKSTLLEHFDILNDVLNGIAYHPSYQEKKISNLNGPVLFVTGKRWPRIYKIELTKIPIRARKNEQINESGDFDKYFEFYSSSIENPSSISNEKFEM</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT74</accession>
    <name>Q5CT74_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_4160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626595.1">
        <property type="nucleotide sequence ID" value="XM_626595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT74"/>
    <dbReference type="GeneID" id="3373486"/>
    <dbReference type="KEGG" id="cpv:cgd2_4160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4160"/>
    <dbReference type="InParanoid" id="Q5CT74"/>
    <dbReference type="OMA" id="NERMETC"/>
    <dbReference type="OrthoDB" id="337494at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="229" mass="26095" checksum="49FDE1EEC1026413" modified="2007-04-03" version="1">MSQKIDLNQGERTESKCPETLNEFSNMYKHKKMPCKSALNFGENIINMGAPSFIPEYPTAYYSNPEVMNQGINSLVDTKQLYDYSSPVGDLEKTIEHYKMSHEIGWNASNSFTPTNSGSLELFQFERRDSPVAVDTLKNYPSFERMNSGFLGFGRKPSNSIFSIGQKLERLSSNEIINNINTLPEIENGIENGIENGIENGDIPHVDLEQYTQLSYFEKYINFNIDQIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT97</accession>
    <name>Q5CT97_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible AAA domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_3880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626572.1">
        <property type="nucleotide sequence ID" value="XM_626572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT97"/>
    <dbReference type="GeneID" id="3373402"/>
    <dbReference type="KEGG" id="cpv:cgd2_3880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3880"/>
    <dbReference type="InParanoid" id="Q5CT97"/>
    <dbReference type="OMA" id="ETIRIQY"/>
    <dbReference type="OrthoDB" id="420422at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030547">
        <property type="entry name" value="XRCC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46644:SF2">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="497" mass="57657" checksum="2610BD7CB19CA210" modified="2005-04-12" version="1">MGMLKFISKSGDLDFRKKEGINDGFSEKINGKIELKDGNENDNNHNHHYNIQEKNLLEVDDTLRGVLIKNLYSMDIKDEILKEILGKENTSFKPGDILGIMGSIGSGKSLLIMHLIAISILPEEIGGHDQKVYYIDTDSGFSIEVFTEKHLIPIIEKKLLNQNFYFQLIEENCKSNKTNFNQKDFDFSKIKTRDEQIIINQIIKKSLSNLNIIFVNDLLDLLCILKQMINNSSINYFNSDFKTITNTNIDFDSNHNHNNKAKLLVIDSINFWNADLSSLIINNYYEQIINKYHILGYFTNKNTIFNSIFSLIRQIVQFHGFIGILSFCEEPIIQFTYNNNNNNNINNNINNNNNNNNNSVNDKFKNNFTEELVEVENLFQNKKNDKNIDNYYDNYISNKKDGIKIDNNINNEKLMLKFPRIIHTKIFPNFLSKILKIEDYQSITNIIWIVKSSLPISDQIHNYPNSSIIPTYFSCISINNLQKSYLAFDDFHGLVLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTB3</accession>
    <name>Q5CTB3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pfa MAL6P1.309 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626556.1">
        <property type="nucleotide sequence ID" value="XM_626556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTB3"/>
    <dbReference type="GeneID" id="3373614"/>
    <dbReference type="KEGG" id="cpv:cgd2_3710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3710"/>
    <dbReference type="InParanoid" id="Q5CTB3"/>
    <dbReference type="OMA" id="YEYTNIF"/>
    <dbReference type="OrthoDB" id="390748at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="495" mass="57169" checksum="00C627183022E203" modified="2005-04-12" version="1">MYLHNKESNVERIRINFKDELGVVATNIFKRAFVSILKKHDKFHNGIVTAEKFCNSIKETDECLRKEDNIWGVIVDSEDKCNVSSPIITSIMSLVQITEDKYVNCKPLYLDVERIVSTVLVKNPYNESTIMVSQIQRTSLEKDHVKYSVRCPKMFLEDLYPPALESANKYSNKNRQNSIFEINRKDFSEENDTEKQEEKLPQLRALPPDKLDDFRKLYAMWNRCMLSDEDFIIHMKKDIGIEQIPREFLLQVANKGPSRTLSFRDAICSLFINDVDSLRKYRPDFLVPQPSRIPIESVYNPVTHEDTIDKSTQRILECCKKGYGKIFNSIDSLNDDMLNDFKSFGRRHKQNSSESAILKKSIEINNQLSNKNEIQVSSSDISSTISPNHSEKPKFDFVINDIDSDEERAKIRGKQLSNYHRLTVTMPNTLQTQLKRCAAGETSGNAIRQYLKYYGIPISVSMDTLLRRSDEDGSVSFTSLMKEVYHSIKNMQSSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTI0</accession>
    <name>Q5CTI0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ER lumen protein retaining receptor 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd2_2920</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626489.1">
        <property type="nucleotide sequence ID" value="XM_626489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTI0"/>
    <dbReference type="STRING" id="353152.Q5CTI0"/>
    <dbReference type="GeneID" id="3373465"/>
    <dbReference type="KEGG" id="cpv:cgd2_2920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2920"/>
    <dbReference type="InParanoid" id="Q5CTI0"/>
    <dbReference type="OMA" id="RFLWAFC"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="77"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="141"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="174"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="236"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="268"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="14">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="308" mass="34857" checksum="63276A67CD6EFEA9" modified="2005-04-12" version="1">MMMYSGHISSKLENDKLSYSCYQGREKLEYNESWFNKIKNRSEVGVSYQSQLEILFWIAFCLLLMVGYKYLSDGSFSAILTLSSAFQCFAFLLLASKVNTQCSLSGISLRSQILYSIALISKLSSTLFFNGYLPVDRSGDWVYQVADVVSLAISLLLIYWGNTKLKYQYKFDKDSVNIVIPIVFSAILAAIIHPDLNSYFPADFAWTFSLYLETTAMLPQLVMMTKIGGEVETLTSHYLASLATSKILSFVFWLFSYRELAPEHGKNVPGWTVMASFAIQIILFTDFLYAYIKSVRLGKALIIPTSIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTP8</accession>
    <name>Q5CTP8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_2160</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88778.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626421.1">
        <property type="nucleotide sequence ID" value="XM_626421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTP8"/>
    <dbReference type="GeneID" id="3373522"/>
    <dbReference type="KEGG" id="cpv:cgd2_2160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2160"/>
    <dbReference type="InParanoid" id="Q5CTP8"/>
    <dbReference type="OMA" id="NILHIRQ"/>
    <dbReference type="OrthoDB" id="340254at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026895">
        <property type="entry name" value="EMC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011678">
        <property type="entry name" value="EMC1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21573:SF0">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07774">
        <property type="entry name" value="EMC1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0732">Signal</keyword>
    <keyword evidence="4 10 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253839" description="ER membrane protein complex subunit 1" evidence="11">
        <location>
            <begin position="25"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="929"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="domain" description="ER membrane protein complex subunit 1 C-terminal" evidence="12">
        <location>
            <begin position="735"/>
            <end position="958"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF07774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88778.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="959" mass="112129" checksum="872089027F129C0A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTQ5</accession>
    <name>Q5CTQ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626414.1">
        <property type="nucleotide sequence ID" value="XM_626414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTQ5"/>
    <dbReference type="STRING" id="353152.Q5CTQ5"/>
    <dbReference type="GeneID" id="3373415"/>
    <dbReference type="KEGG" id="cpv:cgd2_2080"/>
    <dbReference type="InParanoid" id="Q5CTQ5"/>
    <dbReference type="OMA" id="RWSMEYH"/>
    <dbReference type="OrthoDB" id="10250458at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050693">
        <property type="entry name" value="Hsp70_NEF-Inhibitors"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316:SF18">
        <property type="entry name" value="HSP70-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19316">
        <property type="entry name" value="PROTEIN FOLDING REGULATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="268" mass="29942" checksum="35C97FD68B5A3B8D" modified="2005-04-12" version="1">MKNVVDPNKLILEAKDKLSLSNDEEVLASLAVIDRCVELPDCALNFEKLGIVQPLLSCLSRSEEVRSITYQILSKSMQNNLPVQNSFAKLGALSLLKQSVQGEDSETNKSKGITAISSLVRHNKTLEGSFISDNGIPLIALWLHSENVGVRERALSLLRHLLIQGVVKSEYIIGNNNSKIIDTILTLSKNNSISNKEYQNIQYGETISETLLELINAFNPKLSSSSKDKIREEVNKRMIFLIDYCKLHPDDDISPEYSTLIQCEKLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU11</accession>
    <name>Q5CU11_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase III transcription factor (TF)IIIC subunit tau/Tfc1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626308.1">
        <property type="nucleotide sequence ID" value="XM_626308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU11"/>
    <dbReference type="STRING" id="353152.Q5CU11"/>
    <dbReference type="GeneID" id="3373375"/>
    <dbReference type="KEGG" id="cpv:cgd2_730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_730"/>
    <dbReference type="InParanoid" id="Q5CU11"/>
    <dbReference type="OMA" id="PPEYFVR"/>
    <dbReference type="OrthoDB" id="5598268at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001002">
        <property type="term" value="F:RNA polymerase III type 1 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001003">
        <property type="term" value="F:RNA polymerase III type 2 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.160">
        <property type="entry name" value="TFIIIC, subcomplex tauA, subunit Sfc1, barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019136">
        <property type="entry name" value="TF_IIIC_su-5_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040454">
        <property type="entry name" value="TF_IIIC_Tfc1/Sfc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041499">
        <property type="entry name" value="Tfc1/Sfc1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042536">
        <property type="entry name" value="TFIIIC_tauA_Sfc1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230:SF5">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13230">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIIC, POLYPEPTIDE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09734">
        <property type="entry name" value="Tau95"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17682">
        <property type="entry name" value="Tau95_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Transcription factor IIIC subunit Tfc1/Sfc1 triple barrel" evidence="6">
        <location>
            <begin position="10"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="Transcription factor IIIC subunit 5 HTH" evidence="5">
        <location>
            <begin position="127"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF09734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="407" mass="46777" checksum="742ECD653AC66C02" modified="2005-04-12" version="1">MIEIPIKSIVCVEIPGRVENLDNAIFALGGMEGIEESINSKAPMKLLFCREDPYNRPIYSDFMKRTGVLLRKLKYANGRIEWRVIGDVSLVHQFIQMADFYFIPPPGFRDKKTIHEEINEEIVGTPFIPPAVFSKVTHPVNIKWISTNDNFDKSTNINNIASSIAGDTAGTPSALDVRVESGGNEVEMMDITEEQEEQMKSEGQQYWNVVFKYSDSIVPSMPLKISSSINLDKQALGTLKELFEEQPLWLRPVIESKISPEISTWKRKLLFTQVCYNISDGPWRACLCRLGYDPRKDPESRIYQTLDFRDPYLRKVLKEKRIGINVKVEEDLGETILDWQFKVPPKRGSQLYQLSNIEDNHIKKILKEAVPLESCTRESGWLKKSVIDQIRELLSLKCEQMRQLENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU96</accession>
    <name>Q5CU96_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_3700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88978.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626918.1">
        <property type="nucleotide sequence ID" value="XM_626918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU96"/>
    <dbReference type="GeneID" id="3373857"/>
    <dbReference type="KEGG" id="cpv:cgd3_3700"/>
    <dbReference type="InParanoid" id="Q5CU96"/>
    <dbReference type="OMA" id="THETSCN"/>
    <dbReference type="OrthoDB" id="340598at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="677"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="688"/>
            <end position="711"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88978.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="781" mass="91248" checksum="EAF40A90FD0184A6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUA4</accession>
    <name>Q5CUA4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">aspartyl aminopeptidase</fullName>
            <ecNumber evidence="4">3.4.11.21</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd3_3610</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate.</text>
            <dbReference type="EC" id="3.4.11.21"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the peptidase M18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.11.21" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626910.1">
        <property type="nucleotide sequence ID" value="XM_626910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUA4"/>
    <dbReference type="FunCoup" id="Q5CUA4">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUA4"/>
    <dbReference type="GeneID" id="3373936"/>
    <dbReference type="KEGG" id="cpv:cgd3_3610"/>
    <dbReference type="InParanoid" id="Q5CUA4"/>
    <dbReference type="OMA" id="GPILKVN"/>
    <dbReference type="OrthoDB" id="9880441at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05658">
        <property type="entry name" value="M18_DAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.250.10">
        <property type="entry name" value="Aminopeptidase i, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001948">
        <property type="entry name" value="Peptidase_M18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023358">
        <property type="entry name" value="Peptidase_M18_dom2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002759">
        <property type="entry name" value="PRK02813.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28570:SF3">
        <property type="entry name" value="ASPARTYL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02127">
        <property type="entry name" value="Peptidase_M18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00932">
        <property type="entry name" value="AMINO1PTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101821">
        <property type="entry name" value="Aminopeptidase/glucanase lid domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11 12" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="8 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 11" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="6 11" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="468" mass="52433" checksum="18A9FB115FF4A728" modified="2005-04-12" version="1" fragment="single">VSKMTKEFSDKFLEFLNNTGSPYHSVDETIKILKGSGFVKLDDNEEIKKGGKYYITLNYSTILAFKVGEEFDLEDERSMVVITGSHTDSPCLRVRPSSITCNEGYTQLSVSTYGGGLWHTWFDRGLGIAGKVVDNACNEYLIKIKRPICAIPNLAIHLTTSEERSSFVYDKEKHLQPIISKTDTNDKYGEQLLSLPRSLLDEICREINVQPQNISSFDLCLMDSVDSRYVGINDEFIDSPRLDNLGGVFSCFTALIDASESNSSDLLISVAFDHEEVGSVSFSGAHSDFLKQSLKLILAGLENSNLNKSTPKGVVNANRNSDLEFCKIMKRSIFLSVDMAHSIHPNYPERHQSKHKPSPNNGIVIKTNFNQAYTTDCTTRTFLKTIANNFNIKTQDFLVKNSSPCGSTIGPIVASNLGIRTADIGACMLAMHSCREFMYYSDIYDLQNFIKVFYMTWSKVKLESKLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUA7</accession>
    <name>Q5CUA7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SAC3/GANP/THP3 conserved domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_3570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626907.1">
        <property type="nucleotide sequence ID" value="XM_626907.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUA7"/>
    <dbReference type="GeneID" id="3374109"/>
    <dbReference type="KEGG" id="cpv:cgd3_3570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3570"/>
    <dbReference type="InParanoid" id="Q5CUA7"/>
    <dbReference type="OrthoDB" id="264795at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070390">
        <property type="term" value="C:transcription export complex 2"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006406">
        <property type="term" value="P:mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF3">
        <property type="entry name" value="GERMINAL-CENTER ASSOCIATED NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC3/GANP/THP3 conserved" evidence="1">
        <location>
            <begin position="83"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1541" mass="178616" checksum="5D9179BBF207F54C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUI7</accession>
    <name>Q5CUI7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein with UBC domain, ubiquitin conjugating enzyme E2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_2670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626827.1">
        <property type="nucleotide sequence ID" value="XM_626827.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUI7"/>
    <dbReference type="FunCoup" id="Q5CUI7">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUI7"/>
    <dbReference type="GeneID" id="3374062"/>
    <dbReference type="KEGG" id="cpv:cgd3_2670"/>
    <dbReference type="InParanoid" id="Q5CUI7"/>
    <dbReference type="OMA" id="DHKSQYI"/>
    <dbReference type="OrthoDB" id="9984419at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23790">
        <property type="entry name" value="UBCc_UBE2A_2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.110.10:FF:000090">
        <property type="entry name" value="Ubiquitin-conjugating enzyme E2-17 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="1"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="83"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="150" mass="17257" checksum="FF2B10EBE55E7C0F" modified="2005-04-12" version="1" fragment="single">KRRLLRDFAKLSNNPPHGICGTPIDDEMLHWDAVIFGPEGTVWEGGIFKLDIRFTEEYPNKAPKIRFVTRVFHPNIYNNGNICLDILQQHWSPVLDVCSILTCIQSLLNDPNPNSPANAEAAQLYIENKLEYYKMVQKCVKESQEEINNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUM1</accession>
    <name>Q5CUM1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89083.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626793.1">
        <property type="nucleotide sequence ID" value="XM_626793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUM1"/>
    <dbReference type="GeneID" id="3374032"/>
    <dbReference type="KEGG" id="cpv:cgd3_2260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2260"/>
    <dbReference type="InParanoid" id="Q5CUM1"/>
    <dbReference type="OMA" id="QEDHIED"/>
    <dbReference type="OrthoDB" id="340311at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89083.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="140" mass="15547" checksum="826F1C215CCA5C1C" modified="2005-04-12" version="1">MSELEALSNQSTERGVVQENSTEKMDAAENPNEISVDNNAAIELLNVNLQDMFANSFIGANVVNATRMQETIGESWPFDQYQATGLLPVDYAYWLTPYNTSIGPTAFVMMQATATFPDGTQMDAQQARARRRRHVFGVCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUY4</accession>
    <name>Q5CUY4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626680.1">
        <property type="nucleotide sequence ID" value="XM_626680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUY4"/>
    <dbReference type="GeneID" id="3374182"/>
    <dbReference type="KEGG" id="cpv:cgd3_1010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1010"/>
    <dbReference type="InParanoid" id="Q5CUY4"/>
    <dbReference type="OrthoDB" id="341844at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="251" mass="29832" checksum="8908D60FB0EAF42C" modified="2005-04-12" version="1">MNDEVEKLRRQAEIRKRRLLERSSDRLKLIYPNYEESENNESLESIADVRYGESSKSKPISEYESSINETNSRKISKNDTFSDFSQEEIGNQREKQDSRSGFKLVSYIEYWNQREFEKFRKVGSCILGIFLFMIHNFVPDSCLYQFFSAKIRINSISGIVSFIVYQFLVSQVYLYSYFSIFLNYSGSNDNENKKWYKSIFGCNNTQKVDYLVIMNNIIQFAIATRNFISEWFLLVTFYSFFSFIHICFLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV24</accession>
    <name>Q5CV24_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein with 12 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626640.1">
        <property type="nucleotide sequence ID" value="XM_626640.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV24"/>
    <dbReference type="GeneID" id="3373795"/>
    <dbReference type="KEGG" id="cpv:cgd3_550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_550"/>
    <dbReference type="InParanoid" id="Q5CV24"/>
    <dbReference type="OMA" id="RDHEANE"/>
    <dbReference type="OrthoDB" id="340954at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="163"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="349"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="378"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="404"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="432"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="470"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="493" mass="55205" checksum="2FB5CCFD9EB4D397" modified="2005-04-12" version="1">MAGSETDKRRASGRRGSLESGRGDSLGKNSNESNPGVFREMFGTKENPTVIPFKSIIKNPKIYFPIIALTATLTAGHIQNPDATRELFFKSGAFSFAPEMLESGEAFFTINNVMSVANGAVFIGHMIAGSIIDKFGLLPCALVGHILSIFGYTLMFLLHFSSYAYYFAGICFGISLSCTFASRSRFMQMFPKVKNTVGMLLTIGMDFSLLFPLLQDKLSELFGGTKIVMTSMVIIQAIILIHHAFIFPYGKLPDRMEYKNSNNSRNLEDETTDLIQKDETEEIEQDGIQGYRELSCIRKIFSLPFIAFFIYMLFFALSRIHYQLFFRSTCLMNISDQVSAKKAADYGNIVYSLASYLSLAWGYIVDYNGLIITMQYQIALLIGAYFCAGFKSVSNIIPQILSNVFAGLYTCFANSLTYSFVAGVFGYESFGVVQGLASLSAFASLMSINYWQNFLENVLQRDYNLANKLIMYAAIVILVILFILRMIYVRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV30</accession>
    <name>Q5CV30_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative fucose translocator with 8 transmembrane domains, within locus of 3 paralogous genes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626634.1">
        <property type="nucleotide sequence ID" value="XM_626634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV30"/>
    <dbReference type="GeneID" id="3373801"/>
    <dbReference type="KEGG" id="cpv:cgd3_490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_490"/>
    <dbReference type="InParanoid" id="Q5CV30"/>
    <dbReference type="OMA" id="WWTSNIV"/>
    <dbReference type="OrthoDB" id="5547497at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="235"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="268"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="7">
        <location>
            <begin position="45"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="398"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="398"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="432" mass="46790" checksum="8D9F49559F3E9246" modified="2005-04-12" version="1">MGHSKNKKSNSSSGSEAGKESERFISFLPNSVATVLAICSFIAASISSVYFNNGVFKKQIKFPVFVSCAQQLVGMIIMSIFGLIRMAISKSSESGNGKDGAEVQANGSSVSSWKKVMYAIPVAFFFSFNISFNNICLTHGKVSTYAMAKSTTLMWSLCLQFLILGIKVKLTSLISCAIIISGVLIGAFDPKSLVLVSLIYGCISSFSQSCYNITLKWVLPKIGNDSAGLLKYVQMWSILFFFIPMFGTGEVIPAFTTSGCFDFNDLNRMIYLWGLITTSALLAIGVNQSTYVVIGLTTPATFNVCGLVKQALQTIGGIFYLGESLPTQTIIAVCLTFCGSASYTAFNHFGSKPSMSPSELKVVEEKYKEVARQSVGTASDVFENAQDDILKRSGSKTKNMITPFTSKNPEAIPLKDDIEEGLPTGNNNENRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV44</accession>
    <name>Q5CV44_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">poly(A)-specific ribonuclease</fullName>
            <ecNumber evidence="5">3.1.13.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd3_350</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Exonucleolytic cleavage of poly(A) to 5'-AMP.</text>
            <dbReference type="EC" id="3.1.13.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the CAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.13.4" evidence="5"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626620.1">
        <property type="nucleotide sequence ID" value="XM_626620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV44"/>
    <dbReference type="STRING" id="353152.Q5CV44"/>
    <dbReference type="GeneID" id="3374000"/>
    <dbReference type="KEGG" id="cpv:cgd3_350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_350"/>
    <dbReference type="InParanoid" id="Q5CV44"/>
    <dbReference type="OMA" id="IKFMMRA"/>
    <dbReference type="OrthoDB" id="1164111at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004535">
        <property type="term" value="F:poly(A)-specific ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039637">
        <property type="entry name" value="CNOT7/CNOT8/Pop2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006941">
        <property type="entry name" value="RNase_CAF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10797">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04857">
        <property type="entry name" value="CAF1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 15" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="13" id="KW-0804">Transcription</keyword>
    <keyword evidence="12" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK89226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="277" mass="31838" checksum="5E34A3C9A06B6D6A" modified="2005-04-12" version="1">MTNYANNNATVASKKGVIYEVWQNNINEAFQMISEIMDDFPYVAIDTEFPGVVVRPTNNYYEYYYQTVRFNVDLLKVIQIGLSFRNKYGQAPTNICSTFQFNFKFDMECDIYSQESIQFLRHSGIEFDKHLNSGIDFLCFGEYMYGSGLVLNPKVKWISFHGCYDFAYLVKILSSQPLPETETNFIELVKALFPTLYDLKFILKQLSSLSHLSSLQKLSEHLKIQRIGIAHQAGSDALVTCCTFFKLFKLHLNSQVDDNLFNGQIYGFGLPPPTIVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV46</accession>
    <name>Q5CV46_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">Glycylpeptide N-tetradecanoyltransferase</fullName>
            <ecNumber evidence="2 5">2.3.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd3_320</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="11 12 13" key="2">
        <citation type="journal article" date="2023" name="ACS Infect. Dis." volume="9" first="1821" last="1833">
            <title>Identification of and Structural Insights into Hit Compounds Targeting &lt;i&gt;N&lt;/i&gt;-Myristoyltransferase for &lt;i&gt;Cryptosporidium&lt;/i&gt; Drug Development.</title>
            <authorList>
                <person name="Fenwick M.K."/>
                <person name="Reers A.R."/>
                <person name="Liu Y."/>
                <person name="Zigweid R."/>
                <person name="Sankaran B."/>
                <person name="Shin J."/>
                <person name="Hulverson M.A."/>
                <person name="Hammerson B."/>
                <person name="Fernandez Alvaro E."/>
                <person name="Myler P.J."/>
                <person name="Kaushansky A."/>
                <person name="Van Voorhis W.C."/>
                <person name="Fan E."/>
                <person name="Staker B.L."/>
            </authorList>
            <dbReference type="PubMed" id="37722671"/>
            <dbReference type="DOI" id="10.1021/acsinfecdis.3c00151"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 43-469 IN COMPLEX WITH TETRADECANOYL-COA</scope>
    </reference>
    <comment type="function">
        <text evidence="5">Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14 5">
            <text>N-terminal glycyl-[protein] + tetradecanoyl-CoA = N-tetradecanoylglycyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:15521"/>
            <dbReference type="Rhea" id="RHEA-COMP:12666"/>
            <dbReference type="Rhea" id="RHEA-COMP:12667"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
            <dbReference type="ChEBI" id="CHEBI:64723"/>
            <dbReference type="ChEBI" id="CHEBI:133050"/>
            <dbReference type="EC" id="2.3.1.97"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the NMT family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.97" evidence="2 5"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626618.1">
        <property type="nucleotide sequence ID" value="XM_626618.1"/>
    </dbReference>
    <dbReference type="PDB" id="8FBM">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B=43-469"/>
    </dbReference>
    <dbReference type="PDB" id="8FBT">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A/B=42-469"/>
    </dbReference>
    <dbReference type="PDB" id="8FBU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B=43-469"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV46"/>
    <dbReference type="SMR" id="Q5CV46"/>
    <dbReference type="STRING" id="353152.Q5CV46"/>
    <dbReference type="GeneID" id="3373813"/>
    <dbReference type="KEGG" id="cpv:cgd3_320"/>
    <dbReference type="InParanoid" id="Q5CV46"/>
    <dbReference type="OMA" id="GWKRDWH"/>
    <dbReference type="OrthoDB" id="60315at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004379">
        <property type="term" value="F:glycylpeptide N-tetradecanoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.170">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000903">
        <property type="entry name" value="NMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022677">
        <property type="entry name" value="NMT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022676">
        <property type="entry name" value="NMT_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377:SF5">
        <property type="entry name" value="GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11377">
        <property type="entry name" value="N-MYRISTOYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01233">
        <property type="entry name" value="NMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02799">
        <property type="entry name" value="NMT_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015892">
        <property type="entry name" value="N-myristl_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="11 12 13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4 5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase N-terminal" evidence="7">
        <location>
            <begin position="71"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="8">
        <location>
            <begin position="240"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="domain" description="Glycylpeptide N-tetradecanoyltransferase C-terminal" evidence="8">
        <location>
            <begin position="327"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="46"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="179"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="180"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="191"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11 12 13">
        <location>
            <position position="192"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="217"/>
        </location>
        <ligand>
            <name>tetradecanoyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57385"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012923"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01233"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF02799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="8FBM"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="8FBT"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="8FBU"/>
        </source>
    </evidence>
    <sequence length="469" mass="54865" checksum="750165D4FBAF678A" modified="2005-04-12" version="1" fragment="single">LIRMSGETPENSESSISNTKKITNLLKEMSLGSFMNTAANAIKPHKFWNTQPVVQNDDSSSEYSFGPIEIEPDSFRKEIYKLPDGFSWFDCNLWDIESQDFEDTYQLLKDHYVEDDDSQFRFNYSKEFLRWALCVPGQKKNWLVGVRVNETKKMVGFISAIPIKVRIHNCIMNTSVVNFLCVHKKLRSKRLAPVLIKEITRRIRCEKIFQSIYTCGKNITKPFTIGTYWHRIINVKKLLEAGFIGIPRNMTMSSLIKYHRIPADKRIEGFRPSVDSDAEQICKLFENYFMKYKDVSNETMNNLINYDEINHSKELGKQAYMKLDKIEDLQDKITIHQCFNVEDVKHYFTNIDKVIVTYVRENKNKEITDLFSFFIIESTVINNERFPTINIAYSYFNIANTCSLKELFNEMLITAKNNNCDAFNTLDLMQNLQVIQDSKFIIGTGRLRYYVFNWKIPQISPSNVGIILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVA7</accession>
    <name>Q5CVA7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large protein with possible central conserved domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627362.1">
        <property type="nucleotide sequence ID" value="XM_627362.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVA7"/>
    <dbReference type="GeneID" id="3374350"/>
    <dbReference type="KEGG" id="cpv:cgd8_4780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4780"/>
    <dbReference type="InParanoid" id="Q5CVA7"/>
    <dbReference type="OMA" id="ICTESHG"/>
    <dbReference type="OrthoDB" id="67540at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034066">
        <property type="term" value="C:Ric1-Rgp1 guanyl-nucleotide exchange factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040096">
        <property type="entry name" value="Ric1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746:SF10">
        <property type="entry name" value="GUANINE NUCLEOTIDE EXCHANGE FACTOR SUBUNIT RIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22746">
        <property type="entry name" value="RAB6A-GEF COMPLEX PARTNER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="112"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1774" mass="206599" checksum="1A36EA117216E857" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVD5</accession>
    <name>Q5CVD5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627334.1">
        <property type="nucleotide sequence ID" value="XM_627334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVD5"/>
    <dbReference type="STRING" id="353152.Q5CVD5"/>
    <dbReference type="GeneID" id="3374539"/>
    <dbReference type="KEGG" id="cpv:cgd8_4480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4480"/>
    <dbReference type="InParanoid" id="Q5CVD5"/>
    <dbReference type="OMA" id="MFSGAAK"/>
    <dbReference type="OrthoDB" id="342379at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030020">
        <property type="term" value="F:extracellular matrix structural constituent conferring tensile strength"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050149">
        <property type="entry name" value="Collagen_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023:SF1112">
        <property type="entry name" value="COL_CUTICLE_N DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24023">
        <property type="entry name" value="COLLAGEN ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="33"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="335"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="449"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="467"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="498"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="527"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="546" mass="59493" checksum="5067EA7EEBE1386A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVF6</accession>
    <name>Q5CVF6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">FAD/NAD(P)-binding rossman fold oxidoreductase fused to a glucose-methanol-choline (GMC) oxidoreductase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_4230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627313.1">
        <property type="nucleotide sequence ID" value="XM_627313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVF6"/>
    <dbReference type="STRING" id="353152.Q5CVF6"/>
    <dbReference type="GeneID" id="3374546"/>
    <dbReference type="KEGG" id="cpv:cgd8_4230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4230"/>
    <dbReference type="InParanoid" id="Q5CVF6"/>
    <dbReference type="OMA" id="WVISLER"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051871">
        <property type="entry name" value="GMC_Oxidoreductase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45968:SF3">
        <property type="entry name" value="OS04G0573100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45968">
        <property type="entry name" value="OSJNBA0019K04.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254459" evidence="2">
        <location>
            <begin position="30"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="391"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="89"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="882" mass="101269" checksum="BCE6EB3AE2473B64" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVG6</accession>
    <name>Q5CVG6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted hydrolase superfamily, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_4130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627303.1">
        <property type="nucleotide sequence ID" value="XM_627303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVG6"/>
    <dbReference type="GeneID" id="3374188"/>
    <dbReference type="KEGG" id="cpv:cgd8_4130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4130"/>
    <dbReference type="InParanoid" id="Q5CVG6"/>
    <dbReference type="OMA" id="MIEIETA"/>
    <dbReference type="OrthoDB" id="336093at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254273" evidence="3">
        <location>
            <begin position="24"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="117"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="154"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="298"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="156"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="457" mass="52554" checksum="E4116C408A51C5C3" modified="2005-04-12" version="1">MFSKSSLLTLFALLFGYISFIGGFEPWGAQTPYPSELFEPDFIRQVLKEELPQDINETLLEKYVELWTVYPHNLMTTEFPDVFPEDLSLKIHNKLVGRLFLNETKFEDYDKDKCYVLVLSGGSNRGAWEVAALRGLITRYRDEGKIINWDVISGVSVGAIGAYSALFQKSIYEWVNELWNYWWTAQQGILSDCQVPLKKNIGNWIQMLLKKMIDPDAVFQHLCGIAAPRKILKNKFGSNKRNSSRSVTITATRIEDGLPKTWYGWNSTDDELLDAVFASLAYPLVYRPIYVGGSYYMDGGIRGNANLIDPIRHCMEFKNVTIDKVVVDFIETQPIKPNWLWFSPDINIRYHINRAFDILHFNIRGLSKLKEAVETFPQATFRHYLTPSSWSDFQFWPSLALDVTDRPKMIQMMKMGLSVGMRSGTINQTQLLMYNRTTIRTKSIVSLPSLNITSSTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVJ4</accession>
    <name>Q5CVJ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627275.1">
        <property type="nucleotide sequence ID" value="XM_627275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVJ4"/>
    <dbReference type="GeneID" id="3374253"/>
    <dbReference type="KEGG" id="cpv:cgd8_3830"/>
    <dbReference type="InParanoid" id="Q5CVJ4"/>
    <dbReference type="OrthoDB" id="343706at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254276" evidence="2">
        <location>
            <begin position="23"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="104"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="134" mass="14503" checksum="117FEB577872441E" modified="2005-04-12" version="1">MKLILLLILFLVQISYIKVGYGLNVENSIHIQESSINLKTSTKDSLKSKESPVTNLNIPLDGNSTDTNILNALASVLPLKSTSNSPDDAKDKEASDLSYFEPKVLYTTIPVIVICMVGIAVLAELFGDGFESGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVJ8</accession>
    <name>Q5CVJ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sec14'Sec14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627271.1">
        <property type="nucleotide sequence ID" value="XM_627271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVJ8"/>
    <dbReference type="STRING" id="353152.Q5CVJ8"/>
    <dbReference type="GeneID" id="3374284"/>
    <dbReference type="KEGG" id="cpv:cgd8_3790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3790"/>
    <dbReference type="InParanoid" id="Q5CVJ8"/>
    <dbReference type="OMA" id="CENVTVF"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46818:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_125, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46818">
        <property type="entry name" value="DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="159"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="318" mass="37731" checksum="7B608EBC04125F0E" modified="2005-04-12" version="1">MTNSPSPKHQTPHSNSPTHHGHTIKEDRLAKYRNGREKDLTVTKYRPLEVVNFNPPIDAIRHGFGENGMRYIFGDLPLDEFEEGKIREMHTYLKSRHVSLKNTAFCDNHLLLRYLQGNEYDFVKAWDDIKRHVRWRQNFRMIEDRNKLEKLLRNGYCYIHGRDKLLRPIIVFRAKAFLDGEEPDNIIHVVYYWFEFVITNMLAWNRVEQWRVIMDLQDVTFYNAPISLLKDIATNLQRNYRGYLAQMSFINAPIIFWGLWQAISLVLPQSTRDKITLCTSDYKSELLKWINPNQLEKKYHGTASDVNSFREPVLPPLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVL5</accession>
    <name>Q5CVL5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted integral membrane protein, 7-pass transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_3610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627254.1">
        <property type="nucleotide sequence ID" value="XM_627254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVL5"/>
    <dbReference type="GeneID" id="3374306"/>
    <dbReference type="KEGG" id="cpv:cgd8_3610"/>
    <dbReference type="InParanoid" id="Q5CVL5"/>
    <dbReference type="OrthoDB" id="343132at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="345" mass="39722" checksum="3824428B80EF172F" modified="2005-04-12" version="1">MHELHYPDENIDSVKDPEDLSIQEKQLNSKLILVNEIPSGEIMYAENFSYEGEQHSNNKRKENELLSTPEQIEYFNFEDLKKDETKKFSDEKNMKLNTKKKDNKNVKGKTKHKKILEKEDFSSPKLSPEPKNRLDRFQNSLTIPIGCKDKNKTLPKKYSKEYLKYGYDDLQFEIDESISLNPTLPSITSSMQNNLLKEGASYNSSLTLKLKKTLKKRDSEGYSELFDIPSENSEDGNIPITRDTQFLQIIQHKMPKRSNKTLGSPIKPKLLNTKDMLRSEASSETLVLDRNKGSDECYSEIFESSGKKNCEQTACVKIGDLICAPQNNVKKIRVPKSSLPKRKNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVP8</accession>
    <name>Q5CVP8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ABC1 like protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_3250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. ADCK protein kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627221.1">
        <property type="nucleotide sequence ID" value="XM_627221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVP8"/>
    <dbReference type="STRING" id="353152.Q5CVP8"/>
    <dbReference type="GeneID" id="3374248"/>
    <dbReference type="KEGG" id="cpv:cgd8_3250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3250"/>
    <dbReference type="InParanoid" id="Q5CVP8"/>
    <dbReference type="OMA" id="PEYYVPR"/>
    <dbReference type="OrthoDB" id="201153at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13970">
        <property type="entry name" value="ABC1_ADCK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004147">
        <property type="entry name" value="ABC1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034646">
        <property type="entry name" value="ADCK3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051409">
        <property type="entry name" value="Atypical_kinase_ADCK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43851:SF3">
        <property type="entry name" value="COENZYME Q8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03109">
        <property type="entry name" value="ABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="220"/>
            <end position="561"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="561" mass="64403" checksum="CA7A56A75ED82BD9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVQ5</accession>
    <name>Q5CVQ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Protein phosphatase regulator like HEAT repeats containing protein that folds into a alpha-alpha superhelix</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_3180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627214.1">
        <property type="nucleotide sequence ID" value="XM_627214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVQ5"/>
    <dbReference type="STRING" id="353152.Q5CVQ5"/>
    <dbReference type="GeneID" id="3374241"/>
    <dbReference type="KEGG" id="cpv:cgd8_3180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3180"/>
    <dbReference type="InParanoid" id="Q5CVQ5"/>
    <dbReference type="OMA" id="CNENRER"/>
    <dbReference type="OrthoDB" id="2013972at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000070">
        <property type="term" value="P:mitotic sister chromatid segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024741">
        <property type="entry name" value="Condensin2_G2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16199:SF4">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT G2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12422">
        <property type="entry name" value="Condensin2nSMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="831" mass="95850" checksum="1D1328FBDE02C83E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVW0</accession>
    <name>Q5CVW0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_2590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627159.1">
        <property type="nucleotide sequence ID" value="XM_627159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVW0"/>
    <dbReference type="GeneID" id="3374575"/>
    <dbReference type="KEGG" id="cpv:cgd8_2590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2590"/>
    <dbReference type="InParanoid" id="Q5CVW0"/>
    <dbReference type="OrthoDB" id="341764at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="165" mass="19578" checksum="40E4C18B8EB5D91D" modified="2005-04-12" version="1">MNYGNCLSLKSDFENFKSTLIKEGMDEIVCKCFKQVKENIDYLKELNFGENINSLNNESCYIERDLKIKETQHLFKYCIMLLEKENNINPHYKLLFENLLFHFQTIFSLERYEVDNCLRNQLEKNSLSNTSVSSVSSFVHTSQYMPLPDFKELEKQLLFEQNQGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVZ7</accession>
    <name>Q5CVZ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_2190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627122.1">
        <property type="nucleotide sequence ID" value="XM_627122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVZ7"/>
    <dbReference type="GeneID" id="3374561"/>
    <dbReference type="KEGG" id="cpv:cgd8_2190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2190"/>
    <dbReference type="InParanoid" id="Q5CVZ7"/>
    <dbReference type="OMA" id="NQDETMF"/>
    <dbReference type="OrthoDB" id="343130at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="142" mass="16543" checksum="4AB4AFF874D9DC75" modified="2005-04-12" version="1">MDELHPLFRNNVPSTSELKSNEIYSALVEISAQKVQDTSINNNKSQLSKVDKNSSKISVLSKGINKTHNSERYIKGRYQRHLDKIKATKSRMEQEKRQNYLDNITSKNHQVTDDHHHDQQVKELAEMELCMSIWSNKNIFSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW05</accession>
    <name>Q5CW05_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">RAN binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd8_2100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627114.1">
        <property type="nucleotide sequence ID" value="XM_627114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW05"/>
    <dbReference type="GeneID" id="3374553"/>
    <dbReference type="KEGG" id="cpv:cgd8_2100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2100"/>
    <dbReference type="InParanoid" id="Q5CW05"/>
    <dbReference type="OMA" id="PITCEIA"/>
    <dbReference type="OrthoDB" id="185618at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015007">
        <property type="entry name" value="NUP2/50/61"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08911">
        <property type="entry name" value="NUP50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="6" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0811">Translocation</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="RanBD1" evidence="9">
        <location>
            <begin position="237"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="61"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="218"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="68"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="107"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="124"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="137"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="219"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="406" mass="45780" checksum="99CC2BD816132055" modified="2005-04-12" version="1">MSKRVADFQLTSENYDLEERKLCGLSSKENGKNEEGIGGDVIENKEEISTRKIVRIRKRYDDLGDSGSLLTPDTATNSEPIPVVSTFGKDLKDEKSGINDNIIDSSLDEKQNKEEEKNENKDKDEEEKNENEDKEEANEKKNEEEANDKKGEGEIETQKEVENKEEENHKEEILPFGNSGLSSSFKNPFISLAANTENSNFLFSGFSGATKNNSIGIFGASGGDGTGTTGGEEDEENNEEANEEPEIESKAFTGEEHEETVYQCKNVDLFMLKVLENEEKSFRKLATGIIHLNIPKDQNLSELPETSDKNEDTLEDQVSKTITQPRIIFRQKGIYKVLLNSPLNPEISKTFQRNSNIRKGYAVNFIAVGPESEIQQCMLRFQNESDLIDFTDKVHQIVHQHYSKSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW10</accession>
    <name>Q5CW10_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRP5 like protein involved in rRNA biogenesis with 7 S1 domains and 5 HAT repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_2050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627109.1">
        <property type="nucleotide sequence ID" value="XM_627109.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW10"/>
    <dbReference type="GeneID" id="3374496"/>
    <dbReference type="KEGG" id="cpv:cgd8_2050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2050"/>
    <dbReference type="InParanoid" id="Q5CW10"/>
    <dbReference type="OMA" id="WINDPIS"/>
    <dbReference type="OrthoDB" id="412781at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05693">
        <property type="entry name" value="S1_Rrp5_repeat_hs1_sc1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045209">
        <property type="entry name" value="Rrp5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048059">
        <property type="entry name" value="Rrp5_S1_rpt_hs1_sc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 11 PRE-RRNA PROCESSING PROTEIN RRP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23270:SF10">
        <property type="entry name" value="PROTEIN RRP5 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="50"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="501"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="888"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="1360"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="1495"/>
            <end position="1570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1649"/>
            <end position="1697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1649"/>
            <end position="1667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1676"/>
            <end position="1692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2002" mass="228478" checksum="2A441CE8AD94B347" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW37</accession>
    <name>Q5CW37_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_1760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627082.1">
        <property type="nucleotide sequence ID" value="XM_627082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW37"/>
    <dbReference type="SMR" id="Q5CW37"/>
    <dbReference type="GeneID" id="3374501"/>
    <dbReference type="KEGG" id="cpv:cgd8_1760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1760"/>
    <dbReference type="InParanoid" id="Q5CW37"/>
    <dbReference type="OMA" id="MARTINK"/>
    <dbReference type="OrthoDB" id="340363at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14560">
        <property type="entry name" value="Ubiquitin_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254305" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1240"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="712"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="209"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="121"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1240" mass="138976" checksum="885696B6BDAFDA9A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW63</accession>
    <name>Q5CW63_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Bacterial type serine/tyrosine phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_1490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627056.1">
        <property type="nucleotide sequence ID" value="XM_627056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW63"/>
    <dbReference type="STRING" id="353152.Q5CW63"/>
    <dbReference type="GeneID" id="3374585"/>
    <dbReference type="KEGG" id="cpv:cgd8_1490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1490"/>
    <dbReference type="InParanoid" id="Q5CW63"/>
    <dbReference type="OMA" id="CRINEDS"/>
    <dbReference type="OrthoDB" id="9988524at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004721">
        <property type="term" value="F:phosphoprotein phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026893">
        <property type="entry name" value="Tyr/Ser_Pase_IphP-type"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13350">
        <property type="entry name" value="Y_phosphatase3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="422" mass="49494" checksum="385493902AB941C5" modified="2005-04-12" version="1">MFLPRIPYSSKPIIRIENSEEVPFEKGVELFVEGQLEKYNLEERNWYSHGYNYYANIILGKRILLDVIPNIRDISQFLEDESIRRHVLYRGARPGSIEPDKIKHVVRDTLGIKTIIDLRGKLIFEDSYLAKDEILSRSVIWKYYTPTFENESIDNYIEERKDLEHYKIENDREQVSNDVKTLILLNSIDYREPIKLENEKSKELSSDDNQSISPFCLNCMRRYKGMEFESSRKHLNVEEIIFRKRKEAMIPRIISYNYHLFKLISPKLAEKWYVNKYLELRTMGGVYYDIAIFDSKTICRALKVITVSIPPILLHGNLGKDRVGVVIAILLSILGVGEEFIIRDYCASESGLLSITEAIEAEMEHFPDSAKDSNPEYIRYFLSKMKEEFGNMDAYLDLIGFDASWRYKLCNKFKIVPYTNSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWA5</accession>
    <name>Q5CWA5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_1070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627014.1">
        <property type="nucleotide sequence ID" value="XM_627014.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWA5"/>
    <dbReference type="STRING" id="353152.Q5CWA5"/>
    <dbReference type="GeneID" id="3374438"/>
    <dbReference type="KEGG" id="cpv:cgd8_1070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1070"/>
    <dbReference type="InParanoid" id="Q5CWA5"/>
    <dbReference type="OMA" id="NILAWVG"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="389" mass="44887" checksum="2E9788E656874197" modified="2005-04-12" version="1">MDEIGTNKNYIIILLGRRHVKAGFSKKMEPFVILQTSELFSKCVDVLEISENDNTNFSKESNYVTVFKDPINWKRSWSSLIRMLYTDYLMSNPKDYPVILLERPFFPIELSNYIKQILLENYQVPGVKRISEPIVSLFTTGFKTGIVVDIGTNETIVCPIYDGYPIEYNVKIINCGYDDFKKKFMNELFSQYKEKPEEDIIKEISNDLMDDIIFQSGIVNHEFNDNIESNPNITDFTYENLIVKDKYINLVVDKNTRTKPFEIFFGDKAFPNSEVIHHIVLDGIIQVLLNSNIETRKELSQNILICGGLASVPGFERRVSSELGELISNEKILKPLADHFFVTCPPISPFIRSYYGAALMLQHEKINYNFENTNLQRISSKINSKLEIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWE5</accession>
    <name>Q5CWE5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide plus thr stretch, charged repeats, likely mucin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_5410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627859.1">
        <property type="nucleotide sequence ID" value="XM_627859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWE5"/>
    <dbReference type="SMR" id="Q5CWE5"/>
    <dbReference type="STRING" id="353152.Q5CWE5"/>
    <dbReference type="GeneID" id="3375855"/>
    <dbReference type="KEGG" id="cpv:cgd6_5410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5410"/>
    <dbReference type="InParanoid" id="Q5CWE5"/>
    <dbReference type="OMA" id="LCIVERM"/>
    <dbReference type="OrthoDB" id="344358at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd22249">
        <property type="entry name" value="UDM1_RNF168_RNF169-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254575" evidence="2">
        <location>
            <begin position="19"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="649"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="309"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="443"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="514"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="711" mass="80662" checksum="0D8F5F51985A6837" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWF8</accession>
    <name>Q5CWF8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_5270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90096.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627846.1">
        <property type="nucleotide sequence ID" value="XM_627846.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWF8"/>
    <dbReference type="SMR" id="Q5CWF8"/>
    <dbReference type="STRING" id="353152.Q5CWF8"/>
    <dbReference type="GeneID" id="3375841"/>
    <dbReference type="KEGG" id="cpv:cgd6_5270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5270"/>
    <dbReference type="InParanoid" id="Q5CWF8"/>
    <dbReference type="OrthoDB" id="343344at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254577" evidence="1">
        <location>
            <begin position="21"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90096.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="160" mass="18569" checksum="0C54476F96047B42" modified="2007-04-03" version="1">MNIIRLFSGLYLVIIYLSVSNENHEILHTSLANIQSSRKKGKKPSRFDCEQAASEYLEYLLLKNGLMFRVSLTERYSKLLESETNSSLLELYKRKYTKSLQKMSSIAQKIESKHDQARSLFDVLLECLILFGERYSPESIFENNKDALKYLDSVEKLGNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWG9</accession>
    <name>Q5CWG9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">tRNA (guanine(37)-N1)-methyltransferase</fullName>
            <ecNumber evidence="10">2.1.1.228</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">M1G-methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA [GM37] methyltransferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">tRNA methyltransferase 5 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_5130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>guanosine(37) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(37) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:36899"/>
            <dbReference type="Rhea" id="RHEA-COMP:10145"/>
            <dbReference type="Rhea" id="RHEA-COMP:10147"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.228"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="10">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Mitochondrion matrix</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
        <text evidence="10">Predominantly in the mitochondria and in the nucleus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the TRM5 / TYW2 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.228" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627835.1">
        <property type="nucleotide sequence ID" value="XM_627835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWG9"/>
    <dbReference type="STRING" id="353152.Q5CWG9"/>
    <dbReference type="GeneID" id="3375831"/>
    <dbReference type="KEGG" id="cpv:cgd6_5130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5130"/>
    <dbReference type="InParanoid" id="Q5CWG9"/>
    <dbReference type="OMA" id="NCMVFAN"/>
    <dbReference type="OrthoDB" id="408788at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052906">
        <property type="term" value="F:tRNA (guanine(37)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070901">
        <property type="term" value="P:mitochondrial tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.110:FF:000001">
        <property type="entry name" value="tRNA (guanine(37)-N1)-methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.110">
        <property type="entry name" value="Met-10+ protein-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03152">
        <property type="entry name" value="TRM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030382">
        <property type="entry name" value="MeTrfase_TRM5/TYW2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056743">
        <property type="entry name" value="TRM5-TYW2-like_MTfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056744">
        <property type="entry name" value="TRM5/TYW2-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025792">
        <property type="entry name" value="tRNA_Gua_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245:SF43">
        <property type="entry name" value="TRNA (GUANINE(37)-N1)-METHYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23245">
        <property type="entry name" value="TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02475">
        <property type="entry name" value="TRM5-TYW2_MTfase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25133">
        <property type="entry name" value="TYW2_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51684">
        <property type="entry name" value="SAM_MT_TRM5_TYW2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="SAM-dependent methyltransferase TRM5/TYW2-type" evidence="11">
        <location>
            <begin position="161"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="289"/>
            <end position="290"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="359"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51684"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="464" mass="54266" checksum="CBDDF1B8D23A3481" modified="2005-04-12" version="1">MEELRTNIEDCFDTSKIFKSYKLPFIKVKINNCNYVQNLLKENDILFKFPRVSPIINDEKNKENKLILMGEDLLRNYYKVSDKRMKLEDRSNSELESNGDYIIELSDDFFIKIPRNVFIGLNSIDFAEYGIMDFKIEYKYLSYIECARQCIPNNIEIVSSFETIGHIAHLNLNEDNFQYRYILGKILLDKNPGIKTVVTKTGNIESTFRTYPLEVIGGENNLKARLKEQGIIYNINIDQVYWNSRLSNERQRIVELIPRKSIVFDLTCGAGAFTLPLIKIKDCTLFSNDLNPDAIKLLKENMISNKLKDDKVITSQKDCIECIHEILNRNLDPEKIFKIEKNALNLISHENDVFYWICNLPELSLNMLKGFVQGKKTYLEKKIQENSSFRNTMNHFFFYCFSKDPNPKKDIETRIFTFLESDPTTINSEYFSPINLSIHEVRDVSPNKKMYCAQFSMVIPIQVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWK3</accession>
    <name>Q5CWK3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">SNARE associated Golgi protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627801.1">
        <property type="nucleotide sequence ID" value="XM_627801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWK3"/>
    <dbReference type="GeneID" id="3375805"/>
    <dbReference type="KEGG" id="cpv:cgd6_4740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4740"/>
    <dbReference type="InParanoid" id="Q5CWK3"/>
    <dbReference type="OMA" id="EWIETHQ"/>
    <dbReference type="OrthoDB" id="343547at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="103"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="31649" checksum="7DCAB2E801A3784D" modified="2007-04-03" version="1">MTTQTDSRSSSSKILRNATIAFFLILAIVLFVVISRTTIYLIDNLYFFKKIEQISGGNLFILYSLILLNSIFYALLPFSFEPLIFLSAVYYYKNFPFYQGLALSMLSIIIAVNVGSIIIMLISRKIIYPYIKRKQENWDYLNALNDASDNLGLVFVILARLIITPHFFYDIIFGLTNISIPQLIIGNFTFFPRYLSISIFSVVINNIDIFKDRLINLNSDPSSAMFFASISWISFLILVGLLHRSYLKVKGRIPLPTEENHSSLKNSTNALNVEARV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWW6</accession>
    <name>Q5CWW6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_3440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627688.1">
        <property type="nucleotide sequence ID" value="XM_627688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWW6"/>
    <dbReference type="GeneID" id="3375711"/>
    <dbReference type="KEGG" id="cpv:cgd6_3440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3440"/>
    <dbReference type="InParanoid" id="Q5CWW6"/>
    <dbReference type="OMA" id="TSIHEIC"/>
    <dbReference type="OrthoDB" id="340884at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="189" mass="21424" checksum="39BF358B5F1D092D" modified="2005-04-12" version="1">MNDFDIIESQLAKINELRNQVEGIEKTNFNNVNNKTIIDKNLEISISSESTLQERYKSINLLYLVGQKKLIREIINTQSPSNLTNLIKRMINTPPIGDSIEKMACNRNTWIDESIWQLSKVSSEDNSDNTASSDINDKDKNLSEILELLNHYKYHFDSSLQLSGAINLSIGMLNNSNKEESINSSSSPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWY2</accession>
    <name>Q5CWY2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">26S proteasome-associated Mov34/MPN/PAD-1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_3270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627672.1">
        <property type="nucleotide sequence ID" value="XM_627672.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWY2"/>
    <dbReference type="FunCoup" id="Q5CWY2">
        <property type="interactions" value="570"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWY2"/>
    <dbReference type="MEROPS" id="M67.A11"/>
    <dbReference type="GeneID" id="3375698"/>
    <dbReference type="KEGG" id="cpv:cgd6_3270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3270"/>
    <dbReference type="InParanoid" id="Q5CWY2"/>
    <dbReference type="OMA" id="KTGRHEM"/>
    <dbReference type="OrthoDB" id="605656at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08069">
        <property type="entry name" value="MPN_RPN11_CSN5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000026">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000555">
        <property type="entry name" value="JAMM/MPN+_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050242">
        <property type="entry name" value="JAMM_MPN+_peptidase_M67A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037518">
        <property type="entry name" value="MPN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056263">
        <property type="entry name" value="RPN11_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10410">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01398">
        <property type="entry name" value="JAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23594">
        <property type="entry name" value="RPN11_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00232">
        <property type="entry name" value="JAB_MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102712">
        <property type="entry name" value="JAB1/MPN domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50249">
        <property type="entry name" value="MPN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5 8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="MPN" evidence="7">
        <location>
            <begin position="37"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="315" mass="35227" checksum="4085913819396E30" modified="2007-04-03" version="1">MSGFQSNIRSMLGNLHGFGGLMAQDPDAPIPDTSEQVYISSLALLKMLKHGRAGVPMEVMGLLLGEFIDDYSVRVVDVFSMPQSGNSVSVEAVDPVYQTDMLEMLKRVGRSELVVGWYHSHPGFGCWFSGTDVSTQQSFEQLNPRAVGIVVDPIQSVKGKVVIDCFRLISPHSVIAGQEPRQTTSNIGHLQKPSITALVHGLNRNYYSIAIRYRKNLLEQKMLLNLHKPTWSEPLRCDKEENFNERNNSMIKRICETSKQYHESTKLGLSKTSEEFELENVGKIDAKKRLNADVETVLTDNILQILKSNIASSVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWY8</accession>
    <name>Q5CWY8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_3210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627666.1">
        <property type="nucleotide sequence ID" value="XM_627666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWY8"/>
    <dbReference type="FunCoup" id="Q5CWY8">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWY8"/>
    <dbReference type="GeneID" id="3375693"/>
    <dbReference type="KEGG" id="cpv:cgd6_3210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3210"/>
    <dbReference type="InParanoid" id="Q5CWY8"/>
    <dbReference type="OMA" id="EMAHSIM"/>
    <dbReference type="OrthoDB" id="360161at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF15">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="120"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="326"/>
            <end position="467"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00024355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="480" mass="54216" checksum="EA34BE77DD031C2E" modified="2007-04-03" version="1">MDRSSFSILASGTSFTNGRKSRELWEKISYEKARLEEYGNSVENFEKEDKESKGETIINEEYIIDKRNSMNIAVDGDNKTMPLLTFKEIKECGNLPDWVLDNIMNILKYQKPTAIQSQVIPLLFSGVDLLVQSPTGSGKTLCYILPILGRLKNDKVYCANLILSPTRELAQQIVREIKIILDIHGKKYRCRYISGKIDKAQESNTKRLDIAVSTPYRLADICRNNIINLQGCSMIVLDEVDKLLDMGFAPQIDEILSHSNIPKGGKVQIAAFSATLPQIVINLADSIMKSPVKVTLGHRLAASSTIIQELVCVTKDDAKIESLRQLIKQGKIMLPTLVFTNSKDDAQRLFKKLMYDNLIVEAIHSDMPKVKRDNIIQRFRTGKIWILICTDLMARGVDFKNVSCVVNYDFPHSPSNYIHRVGRCGRAGRTGYAITFFTLRDIPKIKSIAKVIKSSGADVPSWMLKVKLNNIKKSHFKKKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX22</accession>
    <name>Q5CX22_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Sucrose-phosphatase-like HAD superfamily hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_2840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90145.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627632.1">
        <property type="nucleotide sequence ID" value="XM_627632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX22"/>
    <dbReference type="STRING" id="353152.Q5CX22"/>
    <dbReference type="DNASU" id="3375890"/>
    <dbReference type="GeneID" id="3375890"/>
    <dbReference type="KEGG" id="cpv:cgd6_2840"/>
    <dbReference type="InParanoid" id="Q5CX22"/>
    <dbReference type="OMA" id="WRYLDIL"/>
    <dbReference type="OrthoDB" id="531008at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006380">
        <property type="entry name" value="SPP-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051518">
        <property type="entry name" value="Sucrose_Phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46521">
        <property type="entry name" value="SUCROSE-PHOSPHATASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46521:SF4">
        <property type="entry name" value="SUCROSE-PHOSPHATASE 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05116">
        <property type="entry name" value="S6PP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01141">
        <property type="entry name" value="C2.B.1:_Sucrose_Phosphatase_Li"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253931" evidence="2">
        <location>
            <begin position="17"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Sucrose phosphatase-like" evidence="3">
        <location>
            <begin position="72"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Sucrose phosphatase-like" evidence="3">
        <location>
            <begin position="216"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90145.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="411" mass="47485" checksum="6AB1AB3409CFF3DC" modified="2005-04-12" version="1" fragment="single">KVNFLLFRAFLEFVLCNTEKTEWDNPPSSYGRKNYFISIKDAERESGKDAKKGLKFCLKDGNLSHIVSRPPIAIVTDLDGTLIGHDEYLKMFNEIWIRQHMFNNSKLIYSTGRNLKDFLLAAKQFNLLRPDYAICGVGTEIYEFPNKEMNLETFCQRLSNTIGRNVTKEELFSLLRFQDMGERVETKEGDEEKVTKDVNPMFPRWCKSRLFAWPVDKWLEIIRKTFNRDELKKEIQENLNKIGLEYYINGNNFHDPFRLSVSIKTEYALKVYEEIQINKKSYRFAISGQGAWKYLDVLPDKGGKHLSIIFLQDEILGNSIPLERFLVCGDSGNDAHMFTIETCKNCCVGNAQQDLKDFLLGGCLVNSDEPESRKVLSSQSELLCRIMACQNLKPPKKVSFTPKMSFCISLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX30</accession>
    <name>Q5CX30_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_2720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627624.1">
        <property type="nucleotide sequence ID" value="XM_627624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX30"/>
    <dbReference type="SMR" id="Q5CX30"/>
    <dbReference type="STRING" id="353152.Q5CX30"/>
    <dbReference type="GeneID" id="3376150"/>
    <dbReference type="KEGG" id="cpv:cgd6_2720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2720"/>
    <dbReference type="InParanoid" id="Q5CX30"/>
    <dbReference type="OMA" id="NCNLIDE"/>
    <dbReference type="OrthoDB" id="343578at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254590" evidence="3">
        <location>
            <begin position="26"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="335"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="290"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="421" mass="46507" checksum="0CDF7762F3217DC6" modified="2007-04-03" version="1">MVSLRALLPFIFLGLFQSIFLFCSGEEILQFCKKHNITLSELEDEAKQAGISISTLISMMNAEYPSPIEETAKSKVDSDSIKDPYTDSPTGNEDVLGFVPSSSVIYSSDIPRNTTIEEPATKIDSEQKVSASLDTETLKLSENTLFVNNADTRASSDKNSKTSESCSCSKHNHSSKTGDCRVIIINESKKNRVKCTKDRNARRSEIGKRYYIINKSGEREEYKVVSHHQKKVRKNKDSKANKLKRVEVVNRHIQPVIIAQPSIAPLYAPMQVPQMPGHPGYVTPPQIPRFPTQGPPQVPPQVPPQAPQMPPQTRDNGDFEYMNKNYNGSDNKNSFIGPLTISVIVIILIISCIIGGFCFCGATGANRNHGNMPLIPPPGTPNAPQNPPYNSRAPIIPQNQPPMQPPPGRQVFGYAVVPNIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXB4</accession>
    <name>Q5CXB4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Tra1p-like C-terminal FAT domain plus phoshoinositide 3-kinase domain very large protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_1740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. TRA1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89842.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627540.1">
        <property type="nucleotide sequence ID" value="XM_627540.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXB4"/>
    <dbReference type="GeneID" id="3376121"/>
    <dbReference type="KEGG" id="cpv:cgd6_1740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1740"/>
    <dbReference type="InParanoid" id="Q5CXB4"/>
    <dbReference type="OMA" id="NEWNQMQ"/>
    <dbReference type="OrthoDB" id="5570127at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000124">
        <property type="term" value="C:SAGA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05163">
        <property type="entry name" value="PIKK_TRRAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003151">
        <property type="entry name" value="PIK-rel_kinase_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014009">
        <property type="entry name" value="PIK_FAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046807">
        <property type="entry name" value="Tra1_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046805">
        <property type="entry name" value="Tra1_ring"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF1">
        <property type="entry name" value="TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02259">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20175">
        <property type="entry name" value="Tra1_central"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20206">
        <property type="entry name" value="Tra1_ring"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51189">
        <property type="entry name" value="FAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="FAT" evidence="4">
        <location>
            <begin position="4088"/>
            <end position="4852"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="3">
        <location>
            <begin position="5131"/>
            <end position="5463"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="5">
        <location>
            <begin position="5505"/>
            <end position="5542"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2661"/>
            <end position="2688"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89842.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="5542" mass="630760" checksum="674C042599573A76" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXB7</accession>
    <name>Q5CXB7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mcm10p-like'Mcm10p-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_1710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627537.1">
        <property type="nucleotide sequence ID" value="XM_627537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXB7"/>
    <dbReference type="STRING" id="353152.Q5CXB7"/>
    <dbReference type="GeneID" id="3376117"/>
    <dbReference type="KEGG" id="cpv:cgd6_1710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1710"/>
    <dbReference type="InParanoid" id="Q5CXB7"/>
    <dbReference type="OMA" id="EYHICIN"/>
    <dbReference type="OrthoDB" id="273123at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040184">
        <property type="entry name" value="Mcm10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055065">
        <property type="entry name" value="OB_MCM10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015408">
        <property type="entry name" value="Znf_Mcm10/DnaG"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13454:SF11">
        <property type="entry name" value="PROTEIN MCM10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22379">
        <property type="entry name" value="OB_MCM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09329">
        <property type="entry name" value="zf-primase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM10 OB-fold" evidence="9">
        <location>
            <begin position="20"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger Mcm10/DnaG-type" evidence="8">
        <location>
            <begin position="153"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF09329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF22379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="585" mass="67490" checksum="1404DF2BA3F77A19" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXE0</accession>
    <name>Q5CXE0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SEC14 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627514.1">
        <property type="nucleotide sequence ID" value="XM_627514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXE0"/>
    <dbReference type="STRING" id="353152.Q5CXE0"/>
    <dbReference type="GeneID" id="3376014"/>
    <dbReference type="KEGG" id="cpv:cgd6_1460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1460"/>
    <dbReference type="InParanoid" id="Q5CXE0"/>
    <dbReference type="OMA" id="QVMFNDF"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051026">
        <property type="entry name" value="PI/PC_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45657:SF1">
        <property type="entry name" value="CRAL-TRIO DOMAIN-CONTAINING PROTEIN YKL091C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03765">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="90"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="341" mass="39785" checksum="54DEAEC84D1D1008" modified="2007-04-03" version="1">MKIRWPKGFGHLSSKHSSCEIDFKEQQLKLSNLLENFNLNLESISESDYKLFFRFLKARQFNVEKSTEMLNKYFEWRGKKKVAELINTTQIPIKIDLYQRAYHGIDRLGRPIYIDCIGSSNIKQMLEIHPEKNFFNQWIYEYEFLVNVISISCQIYNALKEHLPKDSDITNINKDEIMNLLSLGEIQFQNFSTLNIIDMSGFNMGKFDGNCRKVIKELVSISQNYYPELLGKMIVINAPSIFGIIWNFLKPLIDERTAKKISVYTHSDDWKSVLFDLVDPDQLPKFLGGSPNYEGEWFNANIGPWSNQIILECIAEKYPNIPKPLIFSHTISKNNENIPEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXE1</accession>
    <name>Q5CXE1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">N-acetylgalactosaminide beta-1,3-galactosyltransferase</fullName>
            <ecNumber evidence="4">2.4.1.122</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd6_1450</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.122" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627513.1">
        <property type="nucleotide sequence ID" value="XM_627513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXE1"/>
    <dbReference type="SMR" id="Q5CXE1"/>
    <dbReference type="STRING" id="353152.Q5CXE1"/>
    <dbReference type="GeneID" id="3375870"/>
    <dbReference type="KEGG" id="cpv:cgd6_1450"/>
    <dbReference type="InParanoid" id="Q5CXE1"/>
    <dbReference type="OMA" id="LASYKWM"/>
    <dbReference type="OrthoDB" id="414175at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016263">
        <property type="term" value="F:glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026050">
        <property type="entry name" value="C1GALT1/C1GALT1_chp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033">
        <property type="entry name" value="BETA1,3-GALACTOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23033:SF14">
        <property type="entry name" value="GLYCOPROTEIN-N-ACETYLGALACTOSAMINE 3-BETA-GALACTOSYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0732">Signal</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="6 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="12">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254340" description="N-acetylgalactosaminide beta-1,3-galactosyltransferase" evidence="12">
        <location>
            <begin position="28"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="13">
        <location>
            <begin position="76"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="domain" description="Polysaccharide pyruvyl transferase" evidence="14">
        <location>
            <begin position="502"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK90125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="830" mass="95528" checksum="B225F09792C2DC4E" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXN9</accession>
    <name>Q5CXN9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Very large membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_5480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628691.1">
        <property type="nucleotide sequence ID" value="XM_628689.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372155"/>
    <dbReference type="KEGG" id="cpv:cgd7_5480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5480"/>
    <dbReference type="InParanoid" id="Q5CXN9"/>
    <dbReference type="OMA" id="ITICGIC"/>
    <dbReference type="OrthoDB" id="342277at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2323" mass="266161" checksum="B62FFC122E39444A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXS1</accession>
    <name>Q5CXS1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">U1 small nuclear ribonucleoprotein A, rrm domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_5160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628659.1">
        <property type="nucleotide sequence ID" value="XM_628657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXS1"/>
    <dbReference type="STRING" id="353152.Q5CXS1"/>
    <dbReference type="GeneID" id="3371752"/>
    <dbReference type="KEGG" id="cpv:cgd7_5160"/>
    <dbReference type="InParanoid" id="Q5CXS1"/>
    <dbReference type="OMA" id="LFQDLNC"/>
    <dbReference type="OrthoDB" id="277802at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="17"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="122" mass="13610" checksum="F5FBDC3596D0A2C4" modified="2005-04-12" version="1" fragment="single">IMLKKLVSGSEEQPANKTLYCKNLNDKINKKDLKILLFELFIQFGLIDKITIRGGSPYRGQAFILFQDLNCAINAKNSINGMNVLGKPIHIEYAKENSILNPGLAEKKSSGYILGPKMPDNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXS6</accession>
    <name>Q5CXS6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_5110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628654.1">
        <property type="nucleotide sequence ID" value="XM_628652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXS6"/>
    <dbReference type="GeneID" id="3372086"/>
    <dbReference type="KEGG" id="cpv:cgd7_5110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5110"/>
    <dbReference type="InParanoid" id="Q5CXS6"/>
    <dbReference type="OMA" id="IECELAN"/>
    <dbReference type="OrthoDB" id="336808at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="456" mass="51966" checksum="35B6C2E43E22B429" modified="2005-04-12" version="1">MSWWLEKLTKNLTTGINSENSVNHSKNNITSRNESEEEILANDSSIFSQIYELNGCYKCTLRTSGVGLGSYKCDVIFMEKQLIVLHLVSRNNLNISRILAPIAATAFATSFNGDNSKVSKGEWIVLPFDHITGVELQSQGQEVRITTKAGISYFLGDNEECILKVYEIYNERRDSLRDLENKGNAKNPNARSFTIYNADIPISSREHVGKESFSDFAPLSHIFPGCIVSITATELAEILTNDLFYGKYILDPKETFELEISKWEGQSDIVSSDKSEFWLKQGASRDIQYRRKISTGVLDIWVSFTEKHQISFPTDRSFIHILIGVIFTIFEKEVGIKILIRLVEIQENKTQFDLECELENTSSLPYLVRYQLESSTINNIKSTVENYIQGIRDHLSEICSSSMDSIPEFCSNTTICNLNYPENKIGFFKQTTAKCDESMICCFQPFHQVLRSLFQF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXX1</accession>
    <name>Q5CXX1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd7_4600</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628609.1">
        <property type="nucleotide sequence ID" value="XM_628607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXX1"/>
    <dbReference type="FunCoup" id="Q5CXX1">
        <property type="interactions" value="426"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXX1"/>
    <dbReference type="GeneID" id="3372186"/>
    <dbReference type="KEGG" id="cpv:cgd7_4600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4600"/>
    <dbReference type="InParanoid" id="Q5CXX1"/>
    <dbReference type="OMA" id="FKTIWTL"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000657">
        <property type="entry name" value="Probable ATP-dependent RNA helicase DDX41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="139"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="349"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="108"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK90432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="570" mass="64041" checksum="C67D0CE3F5355BB3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY18</accession>
    <name>Q5CY18_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L38</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_4050</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628562.1">
        <property type="nucleotide sequence ID" value="XM_628560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY18"/>
    <dbReference type="FunCoup" id="Q5CY18">
        <property type="interactions" value="391"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY18"/>
    <dbReference type="GeneID" id="3371942"/>
    <dbReference type="KEGG" id="cpv:cgd7_4050"/>
    <dbReference type="InParanoid" id="Q5CY18"/>
    <dbReference type="OMA" id="RCHRFIY"/>
    <dbReference type="OrthoDB" id="10250488at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022618">
        <property type="term" value="P:protein-RNA complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.720.90:FF:000001">
        <property type="entry name" value="60S ribosomal protein L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002675">
        <property type="entry name" value="Ribosomal_eL38"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038464">
        <property type="entry name" value="Ribosomal_eL38_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10965:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01781">
        <property type="entry name" value="Ribosomal_L38e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="82" mass="9507" checksum="B5318833CF45A3E2" modified="2005-04-12" version="1" fragment="single">LVNMPIQITDLRDFINTSRRADARSVTVVKVKKDNHITTKFKIRCSRYLYTLVMKDLEKAKKLESSLPPTLKKTTISRSVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY42</accession>
    <name>Q5CY42_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_3750</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628538.1">
        <property type="nucleotide sequence ID" value="XM_628536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY42"/>
    <dbReference type="FunCoup" id="Q5CY42">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY42"/>
    <dbReference type="GeneID" id="3372124"/>
    <dbReference type="KEGG" id="cpv:cgd7_3750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3750"/>
    <dbReference type="InParanoid" id="Q5CY42"/>
    <dbReference type="OMA" id="YGAMALE"/>
    <dbReference type="OrthoDB" id="47059at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048682">
        <property type="entry name" value="COG4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048684">
        <property type="entry name" value="COG4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013167">
        <property type="entry name" value="COG4_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048680">
        <property type="entry name" value="COG4_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24016:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20662">
        <property type="entry name" value="COG4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08318">
        <property type="entry name" value="COG4_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20663">
        <property type="entry name" value="COG4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00762">
        <property type="entry name" value="Cog4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="COG4 transport protein middle alpha-helical bundle" evidence="9">
        <location>
            <begin position="144"/>
            <end position="474"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="794" mass="92348" checksum="56A7642F6F500971" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY60</accession>
    <name>Q5CY60_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628520.1">
        <property type="nucleotide sequence ID" value="XM_628518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY60"/>
    <dbReference type="GeneID" id="3372108"/>
    <dbReference type="KEGG" id="cpv:cgd7_3570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3570"/>
    <dbReference type="InParanoid" id="Q5CY60"/>
    <dbReference type="OMA" id="PNDSIEC"/>
    <dbReference type="OrthoDB" id="340398at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="624" mass="71548" checksum="2A8239EE14397BFD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY66</accession>
    <name>Q5CY66_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628514.1">
        <property type="nucleotide sequence ID" value="XM_628512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY66"/>
    <dbReference type="GeneID" id="3372103"/>
    <dbReference type="KEGG" id="cpv:cgd7_3500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3500"/>
    <dbReference type="InParanoid" id="Q5CY66"/>
    <dbReference type="OMA" id="HCINGCT"/>
    <dbReference type="OrthoDB" id="20844at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016593">
        <property type="term" value="C:Cdc73/Paf1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007149">
        <property type="entry name" value="Leo1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04004">
        <property type="entry name" value="Leo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="268" mass="30648" checksum="F0CF922C6DE77A3E" modified="2005-04-12" version="1">MMLGHFDNHKDSPSEAIHDSNIDESDSDLFGESDSTPDQVHNDGHCFMIEKDDAKTHTSINDNINCDRINNFEDIKNLKLQLPTNYFGIDNKDQVLLTLKLPERLKVVNKTNVDNTTESGLCIKGGIKGEGDSYSNSKLVSWSDGTYSLFINDELVYDCVIGPDKAFIFDDTFDKKYKVCIERVDNKLTVRPRTIEKSKLLRDSRSRAMMPTTLEEINIHEVESRKRIDELNTISSIKIQQKRTICTTESRKKQMTSHFLEESSEESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY69</accession>
    <name>Q5CY69_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large low comlexity protein, potential zinc ribbon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90346.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628511.1">
        <property type="nucleotide sequence ID" value="XM_628509.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY69"/>
    <dbReference type="GeneID" id="3372061"/>
    <dbReference type="KEGG" id="cpv:cgd7_3470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3470"/>
    <dbReference type="InParanoid" id="Q5CY69"/>
    <dbReference type="OMA" id="DASEYWI"/>
    <dbReference type="OrthoDB" id="343537at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058565">
        <property type="entry name" value="Ig_TRAPPC9_Trs120_1st"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26254">
        <property type="entry name" value="Ig_TRAPPC9-Trs120_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Trs120/TRAPPC9 first Ig-like" evidence="1">
        <location>
            <begin position="816"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF26254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90346.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1330" mass="154013" checksum="F3F60079F3571E7C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYB0</accession>
    <name>Q5CYB0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Importin/karyopherin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_3030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628470.1">
        <property type="nucleotide sequence ID" value="XM_628468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYB0"/>
    <dbReference type="FunCoup" id="Q5CYB0">
        <property type="interactions" value="530"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYB0"/>
    <dbReference type="GeneID" id="3372286"/>
    <dbReference type="KEGG" id="cpv:cgd7_3030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3030"/>
    <dbReference type="InParanoid" id="Q5CYB0"/>
    <dbReference type="OMA" id="QQYQERW"/>
    <dbReference type="OrthoDB" id="10263328at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058584">
        <property type="entry name" value="IMB1_TNPO1-like_TPR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13513">
        <property type="entry name" value="HEAT_EZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25574">
        <property type="entry name" value="TPR_IMB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="6">
        <location>
            <begin position="21"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="882" mass="98157" checksum="8B3898C7B301B853" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYE2</accession>
    <name>Q5CYE2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Clathrin assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_2680</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628438.1">
        <property type="nucleotide sequence ID" value="XM_628436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYE2"/>
    <dbReference type="FunCoup" id="Q5CYE2">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYE2"/>
    <dbReference type="GeneID" id="3371933"/>
    <dbReference type="KEGG" id="cpv:cgd7_2680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2680"/>
    <dbReference type="InParanoid" id="Q5CYE2"/>
    <dbReference type="OMA" id="KPLIWCD"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09250">
        <property type="entry name" value="AP-1_Mu1_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14835">
        <property type="entry name" value="AP1_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018240">
        <property type="entry name" value="Clathrin_mu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00990">
        <property type="entry name" value="CLAT_ADAPTOR_M_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00991">
        <property type="entry name" value="CLAT_ADAPTOR_M_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3 5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="6">
        <location>
            <begin position="180"/>
            <end position="451"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR005992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="453" mass="51391" checksum="43A518F8C5000CE1" modified="2005-04-12" version="1">MCGVSAIFILDINGKPIIGRNYKGDISESGVLDAFQQHVIEQEESCIKPIFSSKMITYCWIKYNNLYLVLLSRKNSNAIMMITFLYKLIEILKDYFKVLEEESIRDNFVVIYELLDEIMDNGFPQITEVKVLREYIKNEAHELSAASVLVQSRNSSSSIKPPSALSNVISWRPEGIKHKKNEIFLDVIEKVNMIIGSSGDVINSEIVGTLTMKSYLSGMPELKLGLNDRLGDASISTSNANRNSASSSNRNSILKNKSVEIEDIKFHQCVRLARFESDRTISFIPPDGQFELMSYRLTPSSNLKPLFKVDVNIENISATRIKYVIKVKGQYKARSVAKNTEIQIPVPSDVIIPTFKTSMGTVKYSPERDLIVWNIKTFSGQKEFTMTAIFDIPSIINETNTSKRPVTVGFEIPYFTISGLTIRYLKITEKSGYQALPWVRYITQNGNYEIRMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYG9</accession>
    <name>Q5CYG9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RRP45-like archaeo-eukaryotic exosomal rnase, PH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_2380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628411.1">
        <property type="nucleotide sequence ID" value="XM_628409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYG9"/>
    <dbReference type="STRING" id="353152.Q5CYG9"/>
    <dbReference type="GeneID" id="3371969"/>
    <dbReference type="KEGG" id="cpv:cgd7_2380"/>
    <dbReference type="InParanoid" id="Q5CYG9"/>
    <dbReference type="OMA" id="TQHESKL"/>
    <dbReference type="OrthoDB" id="10264038at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035925">
        <property type="term" value="F:mRNA 3'-UTR AU-rich region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034473">
        <property type="term" value="P:U1 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034476">
        <property type="term" value="P:U5 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015847">
        <property type="entry name" value="ExoRNase_PH_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050590">
        <property type="entry name" value="Exosome_comp_Rrp42_subfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097:SF14">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP45"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11097">
        <property type="entry name" value="EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03725">
        <property type="entry name" value="RNase_PH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="5">
        <location>
            <begin position="46"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="221"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="432" mass="49175" checksum="45CEF18855443670" modified="2005-04-12" version="1" fragment="single">RLWPIFYKIDNNCKCKKLFIKSIKMDTFIVSVREYGLRLDGRTMNEYRNVKINLNKNYGEVEVNIGRTHVLSVVKSELVAPSQERSSEGFISFTVDIGPLSINPTSHAFRHNRTTLGTEIANYIERILKETGAIDTEILCILSGVCVWSVKCEIHVLFDDGNLFDACLMATLSGLKHYRYNEIDVDSFLKKSKCEGFGERDYQRLENTIRKLEMIPFNVHHFPLSISIGYINGKEGLSYIVDPNSDEESISDTIIHISINDKQEVCGISKFGGAKLSLNQINFAIQIATIHSEKLHQEFKKAFDGEYLKRLKCSDNKGKIVIDQFNTNSKRTETEFDANPPLIMQILSNNEPDKSDNEVSSSIAFSSPSNMEIKNAEFDEYETQHESKLEKASFSDRICESLEQVQLDQSVEPIELLNAVKSNIKIKKRKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYJ9</accession>
    <name>Q5CYJ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Small nuclear ribonucleo protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd7_2040</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628381.1">
        <property type="nucleotide sequence ID" value="XM_628379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYJ9"/>
    <dbReference type="FunCoup" id="Q5CYJ9">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYJ9"/>
    <dbReference type="GeneID" id="3371799"/>
    <dbReference type="KEGG" id="cpv:cgd7_2040"/>
    <dbReference type="InParanoid" id="Q5CYJ9"/>
    <dbReference type="OMA" id="EQTVEYV"/>
    <dbReference type="OrthoDB" id="268799at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005732">
        <property type="term" value="C:sno(s)RNA-containing ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01726">
        <property type="entry name" value="LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000044">
        <property type="entry name" value="Probable U6 snRNA-associated Sm-like protein LSm6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF1">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="10" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Sm" evidence="13">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK90614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="93" mass="10381" checksum="49461CF767FB43BE" modified="2005-04-12" version="1" fragment="single">TRSLRVFENMADSGTIKQNNKSPSDFLRQVIGSPVIVRLNSGVDYKGLLACLDDRMNIAMEDTEEYVDGVFVENHGDTFIRGNNVLYISSPPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYM5</accession>
    <name>Q5CYM5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 9">Exportin-T</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7 9">Exportin(tRNA)</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="8 9">tRNA exportin</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd7_1780</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <text evidence="9">Shuttles between the nucleus and the cytoplasm.</text>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628355.1">
        <property type="nucleotide sequence ID" value="XM_628353.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CYM5">
        <property type="interactions" value="149"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYM5"/>
    <dbReference type="GeneID" id="3371740"/>
    <dbReference type="KEGG" id="cpv:cgd7_1780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1780"/>
    <dbReference type="InParanoid" id="Q5CYM5"/>
    <dbReference type="OMA" id="FINWIDI"/>
    <dbReference type="OrthoDB" id="26399at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016363">
        <property type="term" value="C:nuclear matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071528">
        <property type="term" value="P:tRNA re-export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040017">
        <property type="entry name" value="XPOT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952:SF11">
        <property type="entry name" value="EXPORTIN-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15952">
        <property type="entry name" value="EXPORTIN-T/LOS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="9" id="KW-0813">Transport</keyword>
    <keyword evidence="4 9" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="Exportin-1/Importin-beta-like" evidence="10">
        <location>
            <begin position="121"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00032199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK90220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1303" mass="147371" checksum="E47AB2E70705739D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYR3</accession>
    <name>Q5CYR3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase with possible transmembrane region near N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd7_1330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628317.1">
        <property type="nucleotide sequence ID" value="XM_628315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYR3"/>
    <dbReference type="STRING" id="353152.Q5CYR3"/>
    <dbReference type="GeneID" id="3372259"/>
    <dbReference type="KEGG" id="cpv:cgd7_1330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1330"/>
    <dbReference type="InParanoid" id="Q5CYR3"/>
    <dbReference type="OMA" id="FEWETAS"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="157"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="820" mass="92740" checksum="E15928FA0F5D67B7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYW7</accession>
    <name>Q5CYW7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628263.1">
        <property type="nucleotide sequence ID" value="XM_628261.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372017"/>
    <dbReference type="KEGG" id="cpv:cgd7_740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_740"/>
    <dbReference type="InParanoid" id="Q5CYW7"/>
    <dbReference type="OMA" id="NTMITEM"/>
    <dbReference type="OrthoDB" id="342882at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1305"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="341"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1315"/>
            <end position="1328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1385" mass="162935" checksum="960247CC025A2D6E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPY1</accession>
    <name>A3FPY1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Coatomer protein complex subunit alpha, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd8_860</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388422.1">
        <property type="nucleotide sequence ID" value="XM_001388385.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A3FPY1">
        <property type="interactions" value="502"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPY1"/>
    <dbReference type="GeneID" id="3374641"/>
    <dbReference type="KEGG" id="cpv:cgd8_860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_860"/>
    <dbReference type="InParanoid" id="A3FPY1"/>
    <dbReference type="OMA" id="EMTYQKQ"/>
    <dbReference type="OrthoDB" id="10261470at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.470:FF:000002">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000010">
        <property type="entry name" value="Coatomer subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010714">
        <property type="entry name" value="Coatomer_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF1">
        <property type="entry name" value="COATOMER SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06957">
        <property type="entry name" value="COPI_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="47"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="89"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="209"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="253"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="12">
        <location>
            <begin position="576"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="14">
        <location>
            <begin position="787"/>
            <end position="895"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer alpha subunit C-terminal" evidence="13">
        <location>
            <begin position="1079"/>
            <end position="1381"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAZ51462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1382" mass="156339" checksum="A230A0D745A21645" modified="2007-04-03" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ32</accession>
    <name>A3FQ32_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_2430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388112.1">
        <property type="nucleotide sequence ID" value="XM_001388075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ32"/>
    <dbReference type="GeneID" id="3374075"/>
    <dbReference type="KEGG" id="cpv:cgd3_2430"/>
    <dbReference type="InParanoid" id="A3FQ32"/>
    <dbReference type="OMA" id="VICIEEW"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAZ51440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="129" mass="14982" checksum="2EF73A7F907B40F6" modified="2007-04-03" version="1" fragment="single">TLEITTSILIDCLKEILEEIKQIRQKDGDELVICIEEWEDILHRYIPAIYLASKELTEVKSSITFSDELSKVYLDFQRNEYMYTNLKISLLTLSCSITSVITGKSDFANINKKLISLTRNIRNESSQWN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQB6</accession>
    <name>A3FQB6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Exonuclease V</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the EXO5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388138.1">
        <property type="nucleotide sequence ID" value="XM_001388101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQB6"/>
    <dbReference type="FunCoup" id="A3FQB6">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQB6"/>
    <dbReference type="GeneID" id="3371503"/>
    <dbReference type="KEGG" id="cpv:cgd1_500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_500"/>
    <dbReference type="InParanoid" id="A3FQB6"/>
    <dbReference type="OMA" id="CPDKPLG"/>
    <dbReference type="OrthoDB" id="354769at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045145">
        <property type="term" value="F:single-stranded DNA 5'-3' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019190">
        <property type="entry name" value="EXOV"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14464:SF4">
        <property type="entry name" value="EXONUCLEASE V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09810">
        <property type="entry name" value="Exo5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="446" mass="51354" checksum="052E70AF3E023476" modified="2007-04-03" version="1">MNISSFRIKRRKKSEDDDDEKKDSSSYEELLEVIAPINKFKSKPALGVTTFSRQMWCEKSLEICLENNIKITSKAIEEGIKHHEELELEDHQVLSVMVENEYEKMAIEILSIVNLLDGLIERGYIRELPIIGFYKGIMLRGIIDSLQLKPKLNGIGETNNVKYSSNNINKFIILISDTKTRRNTTLPSNVQQKTTVLQLGLYRKILGEMINFGKIWKSCHPNLIDSNAIKKYLNSSSTIDLSNCCSGCSFLNNIFEFHGLDPLISFSIFQELEDAKRKQSCKEKNDICDTNQDQIQTETHSETESVVDTDGKSVLKEFENALEIGFNMLLCFSKLPDIQSEMKVEYDCQGKTFATKWYKSSEQTIELELDYLLGWWLGAREAEFVRISEAWKCKFCNVIEYCQVCPLSKEEKEKCIEKIRQDELESLLIKDLEESSNEHILTLNCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQL1</accession>
    <name>A3FQL1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_2320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388066.1">
        <property type="nucleotide sequence ID" value="XM_001388029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQL1"/>
    <dbReference type="FunCoup" id="A3FQL1">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQL1"/>
    <dbReference type="GeneID" id="3372824"/>
    <dbReference type="KEGG" id="cpv:cgd4_2320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2320"/>
    <dbReference type="InParanoid" id="A3FQL1"/>
    <dbReference type="OMA" id="CCLRFYL"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010992">
        <property type="term" value="P:ubiquitin recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.870">
        <property type="entry name" value="PFU (PLAA family ubiquitin binding), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015155">
        <property type="entry name" value="PFU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038122">
        <property type="entry name" value="PFU_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013535">
        <property type="entry name" value="PUL_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19849:SF0">
        <property type="entry name" value="PHOSPHOLIPASE A-2-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09070">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08324">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51394">
        <property type="entry name" value="PFU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51396">
        <property type="entry name" value="PUL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="9"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="101"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="PFU" evidence="6">
        <location>
            <begin position="393"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="domain" description="PUL" evidence="7">
        <location>
            <begin position="504"/>
            <end position="824"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="829" mass="95330" checksum="C9746A3714C6CE15" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="29" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQM7</accession>
    <name>A3FQM7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_31</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAZ51233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388045.1">
        <property type="nucleotide sequence ID" value="XM_001388008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQM7"/>
    <dbReference type="GeneID" id="4910865"/>
    <dbReference type="KEGG" id="cpv:cgd4_31"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_31"/>
    <dbReference type="InParanoid" id="A3FQM7"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAZ51233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="88" mass="9785" checksum="5535FB3A68885C54" modified="2007-04-03" version="1">MGAEISNCQFTKLGDACYSPFSMINNTLSEAAANNFVLNLEKSKFKSENNQYWLSCMVGSVPYNGTLECDVENYATIICGNSKLYNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQR8</accession>
    <name>A3FQR8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Casein kinase I</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd3_40</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAZ51201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388088.1">
        <property type="nucleotide sequence ID" value="XM_001388051.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQR8"/>
    <dbReference type="STRING" id="353152.A3FQR8"/>
    <dbReference type="GeneID" id="3372329"/>
    <dbReference type="KEGG" id="cpv:cgd3_40"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_40"/>
    <dbReference type="InParanoid" id="A3FQR8"/>
    <dbReference type="OMA" id="NILSCAY"/>
    <dbReference type="OrthoDB" id="337570at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000596">
        <property type="entry name" value="CK1 family protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050235">
        <property type="entry name" value="CK1_Ser-Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11909">
        <property type="entry name" value="CASEIN KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 5 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="18"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="342"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="390"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="401"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="430"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="449"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="493" mass="56426" checksum="63C403187A4B15DF" modified="2007-04-03" version="1">MVSQISSPLSNTTVCSIWKIERLIGGGSFGDIYLAVNTETNEEVAIKAESTMSRHPQLIYETKVLKLLQGGVGIANVYHCELDREVNHQIMAMELLGPSLEDLFNLCHRRFTMKTILMIADQMLQRVEYIHSKNFIHRDIKPDNFLIGRGRGSRNIYVIDFGLAKRFRDPKTLQHIPYRENKNLTGTARYASINAHLGIEQSRRDDLEAIGYVLMYFCRNGTLPWQGIRANNKEEKYKKIMEKKMGTSVETLCKSYPPEFATYLHYCRVLRFEDRPDYTYLRKLFRDLMQREGYVDDGDFDWTKLDSNSSKKVETSSMQTNNCVKTTGKSLIPQIQPNVSLDKSVFDQKKQSKSNKRYIHSSSSRKANNSGAPANSNIIQRECSPVEQKSNMENKGEKNPNETANSNICNNLTSANSGKRISDIGDQAQDHSMSLSPNPTLTRRKSKAKNKDIHEYRNTKYQDTSSKKHNMKTHNTQKPSKLKRGFCSCTKVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPD6</accession>
    <name>Q5CPD6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_4570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000018">
        <property type="protein sequence ID" value="EAK87291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625305.1">
        <property type="nucleotide sequence ID" value="XM_625305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPD6"/>
    <dbReference type="STRING" id="353152.Q5CPD6"/>
    <dbReference type="GeneID" id="3372304"/>
    <dbReference type="KEGG" id="cpv:cgd5_4570"/>
    <dbReference type="InParanoid" id="Q5CPD6"/>
    <dbReference type="OrthoDB" id="340213at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="376" mass="44006" checksum="24CCD336D055759A" modified="2005-04-12" version="1">MKFLKFLKYIPLPIFTLIIHTFSLKSDNVIKSNNLGFNQFNLNSILGNNYPDVELTIEPITTSSIKNEFSQTVNGFSKLKKNTQKYKIGNSNHRYYLVAIESINKKSRFPFYGTFITLVSCENINRMITYEQTNKQFVNIILNCIGNANVKFDHGKLTIIIEKNKYSSIEATSYKIKDFPALPKFLTNFRDDLFALNFKHEVDQSFHISVYIPQYIGYISLDSQYYYEVTFDQKYVHIPYSDKYRYIIFESTDYNYAIPIHNECHAKVNVEEGIIENTCGSLEYLYDIRNGLLFYKGVELLTRNIGGLRVIITNNMENLIILSKETLYYVEQLSKNNEKKQKEKKISQVNQQEQLNNNVTSEKKILRKGFDPFNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPK4</accession>
    <name>Q5CPK4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_50</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625345.1">
        <property type="nucleotide sequence ID" value="XM_625345.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPK4"/>
    <dbReference type="GeneID" id="3375665"/>
    <dbReference type="KEGG" id="cpv:cgd6_50"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_50"/>
    <dbReference type="InParanoid" id="Q5CPK4"/>
    <dbReference type="OrthoDB" id="10419640at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="174" mass="19242" checksum="F6887D58ED77A5C2" modified="2007-04-03" version="1">MEQLSDIPPPPSYPAPVLKTNIHHFDEAPNLHPTIKQSTVQNPQKKVANSQIGFKSSSLIINKEEITLGLRSLRRTGSRFLPPNSSIYSFEKTPPEIPKKPTFNPYLNKYGLVGNSARAKSISNQSGHFETNNEPESVEKRRENQSTAIPPPPLSPPPPPPSSTIKSAVTNRIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPU6</accession>
    <name>Q5CPU6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide plus transmembrane domain or GPI anchor, proline rich, acidic stretches</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_3970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625418.1">
        <property type="nucleotide sequence ID" value="XM_625418.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPU6"/>
    <dbReference type="STRING" id="353152.Q5CPU6"/>
    <dbReference type="GeneID" id="3372426"/>
    <dbReference type="KEGG" id="cpv:cgd4_3970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3970"/>
    <dbReference type="InParanoid" id="Q5CPU6"/>
    <dbReference type="OMA" id="ANTIYTQ"/>
    <dbReference type="OrthoDB" id="344213at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711:SF1">
        <property type="entry name" value="ECTODERMAL, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35711">
        <property type="entry name" value="EXPRESSED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="832"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="177"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="446"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="183"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="691"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="861" mass="96111" checksum="417422A05514AB1C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ13</accession>
    <name>Q5CQ13_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal peptide, predicted secreted protein of cryptosprodidium-specific SKSR gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_20</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625466.1">
        <property type="nucleotide sequence ID" value="XM_625466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ13"/>
    <dbReference type="STRING" id="353152.Q5CQ13"/>
    <dbReference type="GeneID" id="3372486"/>
    <dbReference type="KEGG" id="cpv:cgd8_20"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_20"/>
    <dbReference type="InParanoid" id="Q5CQ13"/>
    <dbReference type="OrthoDB" id="343890at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="469"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="528"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="572"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="706"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="469"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="572"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="598"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="710"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="746"/>
            <end position="790"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="924" mass="107985" checksum="EAA7BEBD0592B66F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ29</accession>
    <name>Q5CQ29_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_4350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625597.1">
        <property type="nucleotide sequence ID" value="XM_625597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ29"/>
    <dbReference type="GeneID" id="3372581"/>
    <dbReference type="KEGG" id="cpv:cgd5_4350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4350"/>
    <dbReference type="InParanoid" id="Q5CQ29"/>
    <dbReference type="OMA" id="RIKEFNI"/>
    <dbReference type="OrthoDB" id="341784at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1056" mass="123057" checksum="B01B62722252F06F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ59</accession>
    <name>Q5CQ59_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inositol-pentakisphosphate 2-kinase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_4030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625567.1">
        <property type="nucleotide sequence ID" value="XM_625567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ59"/>
    <dbReference type="GeneID" id="3372518"/>
    <dbReference type="KEGG" id="cpv:cgd5_4030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4030"/>
    <dbReference type="InParanoid" id="Q5CQ59"/>
    <dbReference type="OMA" id="CNINNEL"/>
    <dbReference type="OrthoDB" id="339431at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="537" mass="62965" checksum="D734DA2071D848CC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ83</accession>
    <name>Q5CQ83_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">HIT-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd5_3780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Required for box C/D snoRNAs accumulation involved in snoRNA processing, snoRNA transport to the nucleolus and ribosome biogenesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the BCD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625543.1">
        <property type="nucleotide sequence ID" value="XM_625543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ83"/>
    <dbReference type="STRING" id="353152.Q5CQ83"/>
    <dbReference type="GeneID" id="3372588"/>
    <dbReference type="KEGG" id="cpv:cgd5_3780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3780"/>
    <dbReference type="InParanoid" id="Q5CQ83"/>
    <dbReference type="OMA" id="YDENAFY"/>
    <dbReference type="OrthoDB" id="272357at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070761">
        <property type="term" value="C:pre-snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000492">
        <property type="term" value="P:box C/D snoRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048254">
        <property type="term" value="P:snoRNA localization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23023">
        <property type="entry name" value="zf-HIT_BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051639">
        <property type="entry name" value="BCD1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057721">
        <property type="entry name" value="BCD1_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007529">
        <property type="entry name" value="Znf_HIT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483:SF3">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13483">
        <property type="entry name" value="BOX C_D SNORNA PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25790">
        <property type="entry name" value="BCD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04438">
        <property type="entry name" value="zf-HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51083">
        <property type="entry name" value="ZF_HIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="HIT-type" evidence="8">
        <location>
            <begin position="18"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00049654"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00453"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="283" mass="33494" checksum="13510164984D4253" modified="2005-04-12" version="1">MEIDDALLAEKRDQNRKCENCDNDYKYKCPACNTKSCSLECINHHKSKTGCDGDGMKKHIGRNIAISQYNCDDMWRDFNFLEEMRRRILNASRHQGKEKHIENQIIQQNFGLISSLRGRIGEYKGRVKTNEEQKLVTVIKETSKLPRHSPIPLLKKACSIRKIKIYFCPINEMEIRKNNTTYYNKKDDLILWKMEFNIYQDNNLIEKKYLDNISENEIVIEIILKLIINLDKNNIKQVLLMNNFKDENNKAFQEIDLNKSFKENLIGKNIIEFPRFKVEIHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQB5</accession>
    <name>Q5CQB5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative ABC transporter with 11 transmembrane domains, AAA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd4_1370</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625733.1">
        <property type="nucleotide sequence ID" value="XM_625733.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQB5"/>
    <dbReference type="GeneID" id="3372639"/>
    <dbReference type="KEGG" id="cpv:cgd4_1370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1370"/>
    <dbReference type="InParanoid" id="Q5CQB5"/>
    <dbReference type="OMA" id="VYISILM"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="108"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="146"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="232"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="263"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="346"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="845"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="888"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="926"/>
            <end position="948"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="969"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="991"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1082"/>
            <end position="1101"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1217"/>
            <end position="1336"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1151"/>
            <end position="1178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1490" mass="170937" checksum="89F06FC8DAA2496E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQB7</accession>
    <name>Q5CQB7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bromo domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd4_1340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="7" key="2">
        <citation type="submission" date="2016-12" db="PDB data bank">
            <title>Second Bromodomain of cdg4_1340 from Cryptosporidium parvum, complexed with bromosporine.</title>
            <authorList>
                <consortium name="Structural Genomics Consortium (SGC)"/>
                <person name="Hou C.F.D."/>
                <person name="Lin Y.H."/>
                <person name="Loppnau P."/>
                <person name="Hutchinson A."/>
                <person name="Dong A."/>
                <person name="Bountra C."/>
                <person name="Edwards A.M."/>
                <person name="Arrowsmith C.H."/>
                <person name="Hui R."/>
                <person name="Walker J.R."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.40 ANGSTROMS) OF 300-450</scope>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_625731.1"/>
    </dbReference>
    <dbReference type="PDB" id="5U9N">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.40 A"/>
        <property type="chains" value="A/B=300-450"/>
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    <dbReference type="AlphaFoldDB" id="Q5CQB7"/>
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    <dbReference type="STRING" id="353152.Q5CQB7"/>
    <dbReference type="GeneID" id="3372614"/>
    <dbReference type="KEGG" id="cpv:cgd4_1340"/>
    <dbReference type="InParanoid" id="Q5CQB7"/>
    <dbReference type="OMA" id="NNNDPWP"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
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    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
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    <dbReference type="GO" id="GO:0005634">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
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    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
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        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
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    <keyword evidence="7" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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            <begin position="27"/>
            <end position="92"/>
        </location>
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            <end position="420"/>
        </location>
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        </location>
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        </location>
    </feature>
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        </location>
    </feature>
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            <end position="393"/>
        </location>
    </feature>
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        <location>
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            <end position="617"/>
        </location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="3">
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            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="191"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="226"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="569"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="7">
        <source>
            <dbReference type="PDB" id="5U9N"/>
        </source>
    </evidence>
    <sequence length="809" mass="93153" checksum="65D904B4CB0FC173" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQD3</accession>
    <name>Q5CQD3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625715.1">
        <property type="nucleotide sequence ID" value="XM_625715.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQD3"/>
    <dbReference type="GeneID" id="3372668"/>
    <dbReference type="KEGG" id="cpv:cgd4_1180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1180"/>
    <dbReference type="InParanoid" id="Q5CQD3"/>
    <dbReference type="OrthoDB" id="343851at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="110" mass="13027" checksum="373568D123F2C3B1" modified="2005-04-12" version="1">MSAFISTSFSLLLKELFSNKSIDTLKDKILENIDIKSAQILSKNIKKKHVSKLFNRFLLFSFLFFSTGLGYYYYTKIYKKRANKDPNYRAYNLFGDIFSKFSRKKFTKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQD4</accession>
    <name>Q5CQD4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">26S proteasome regulatory subunit 4 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd4_1170</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625714.1">
        <property type="nucleotide sequence ID" value="XM_625714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQD4"/>
    <dbReference type="FunCoup" id="Q5CQD4">
        <property type="interactions" value="388"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQD4"/>
    <dbReference type="GeneID" id="3372671"/>
    <dbReference type="KEGG" id="cpv:cgd4_1170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1170"/>
    <dbReference type="InParanoid" id="Q5CQD4"/>
    <dbReference type="OMA" id="QDDTDPM"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
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        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000030">
        <property type="entry name" value="26S protease regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="26S proteasome regulatory subunit 4"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="223"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK87628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="445" mass="49646" checksum="C5D937DF54E80CF8" modified="2005-04-12" version="1">MGNSHGVLGEGGMKNNRKSKNNGKDEKKKLESAPPPMEMKRKRKQKGPPQYARLPAVVPNAKCRLRLLKYERIKDYLMMEQEFITSMESVKPSAETAEEEHNKVDDLRGSPMNIGTLEEIIDENHAIVSSSVGSEYYVNILSFVDKNQLEPGSSVLLHNKVYSVVGIMNDEVDPLVSVMKVDKAPLESYADIGGLEQQIQEIKEAVEIPLTHPELYDDIGIKPPKGVILYGPPGTGKTLLAKAVANETSATFLRVVGSELIQKYLGDGPKLVRELFRVAEENAPSIVFIDEIDAVGTKRHDSQSGGERDIQRTMLELLNQLDGFEARGDVKVIMATNKIESLDPALIRPGRIDRKIELPNPDCKTKRRIFQIHTSKMTLSDDVDLEEFIMAKDDISGADIKAICTEAGLLALRERRMRVTQEDLRKAKEKALYRKKGGIPEGLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQG7</accession>
    <name>Q5CQG7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Small conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87721.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625681.1">
        <property type="nucleotide sequence ID" value="XM_625681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQG7"/>
    <dbReference type="GeneID" id="3372652"/>
    <dbReference type="KEGG" id="cpv:cgd4_790"/>
    <dbReference type="InParanoid" id="Q5CQG7"/>
    <dbReference type="OMA" id="HAYEDCF"/>
    <dbReference type="OrthoDB" id="370932at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1050.10">
        <property type="entry name" value="At2g23090-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039713">
        <property type="entry name" value="At2g23090-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039438">
        <property type="entry name" value="At2g23090-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007513">
        <property type="entry name" value="SERF-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026939">
        <property type="entry name" value="ZNF706/At2g23090_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788">
        <property type="entry name" value="OS07G0114300 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR33788:SF1">
        <property type="entry name" value="ZINC-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04419">
        <property type="entry name" value="SERF-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12907">
        <property type="entry name" value="zf-met2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118359">
        <property type="entry name" value="Expressed protein At2g23090/F21P24.15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small EDRK-rich factor-like N-terminal" evidence="2">
        <location>
            <begin position="6"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="At2g23090-like zinc-binding" evidence="3">
        <location>
            <begin position="46"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04419"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12907"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87721.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="82" mass="9617" checksum="43B804308CCADFBB" modified="2005-04-12" version="1" fragment="single">KEEIKMSRGNQRDIDRQRAQKRQDRTAPKTGKSIIEQKEKILSIVCNICKQTFMCTANRQTLEVHVDTKHPKLEFSQCFPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQG9</accession>
    <name>Q5CQG9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low complexity protein with large Glu repeat</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625679.1">
        <property type="nucleotide sequence ID" value="XM_625679.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQG9"/>
    <dbReference type="GeneID" id="3372743"/>
    <dbReference type="KEGG" id="cpv:cgd4_770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_770"/>
    <dbReference type="InParanoid" id="Q5CQG9"/>
    <dbReference type="OMA" id="INDEHKH"/>
    <dbReference type="OrthoDB" id="344318at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="369"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="602"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="740"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="780"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="969"/>
            <end position="1032"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1049"/>
            <end position="1127"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1387"/>
            <end position="1439"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="28"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="184"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1197"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="369"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="614"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="649"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1262"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1403"/>
            <end position="1433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1439" mass="176622" checksum="3CB9D171DE8665D1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQH0</accession>
    <name>Q5CQH0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative ASF1 anti-silencing function 1 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ASF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625678.1">
        <property type="nucleotide sequence ID" value="XM_625678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQH0"/>
    <dbReference type="FunCoup" id="Q5CQH0">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQH0"/>
    <dbReference type="GeneID" id="3372653"/>
    <dbReference type="KEGG" id="cpv:cgd4_760"/>
    <dbReference type="InParanoid" id="Q5CQH0"/>
    <dbReference type="OMA" id="PRIVKFC"/>
    <dbReference type="OrthoDB" id="29755at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1490">
        <property type="entry name" value="Histone chaperone ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006818">
        <property type="entry name" value="ASF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036747">
        <property type="entry name" value="ASF1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040">
        <property type="entry name" value="ANTI-SILENCING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12040:SF0">
        <property type="entry name" value="HISTONE CHAPERONE ASF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04729">
        <property type="entry name" value="ASF1_hist_chap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101546">
        <property type="entry name" value="ASF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="176"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="180"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="246" mass="27811" checksum="F3FB865B47F87269" modified="2005-04-12" version="1" fragment="single">KYKKYRKKKMSLVNVTSVKVFKNPTEITDPFEFEISFECLQNLEEDLEWKIVYISCAESKDMDQELDCIALGPITRGALKFIFKAPSPDFTKIPPEDIHGMAVVLILGSYRNEEFIRIGYYVHNVYTDPLLEDNPPDIPILDKLQRIILSESPRLTRFNIGWDTKQEDQNLSSCCDEDQINSQKSSNNDSQDSINSQISSNSSPKPSQISNLNSQKLSSSQGPTSQSSNPNNNENLDANMSTISSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQL7</accession>
    <name>Q5CQL7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625631.1">
        <property type="nucleotide sequence ID" value="XM_625631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQL7"/>
    <dbReference type="GeneID" id="3372715"/>
    <dbReference type="KEGG" id="cpv:cgd4_220"/>
    <dbReference type="InParanoid" id="Q5CQL7"/>
    <dbReference type="OrthoDB" id="340673at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="115" mass="13806" checksum="AA5DC1E5C578B26D" modified="2005-04-12" version="1">MLSSFMAIKKILQIQSKYSANNDYFDTVVLLRVNIALMEITLESKLNEIPEDARNKVFELKKRIITNNYVLNKYYQNQFNILNLERKNLFKVFLRYFIYPAYLDLYSYGNIILSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQM7</accession>
    <name>Q5CQM7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87735.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625621.1">
        <property type="nucleotide sequence ID" value="XM_625621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQM7"/>
    <dbReference type="STRING" id="353152.Q5CQM7"/>
    <dbReference type="GeneID" id="3372666"/>
    <dbReference type="KEGG" id="cpv:cgd4_120"/>
    <dbReference type="InParanoid" id="Q5CQM7"/>
    <dbReference type="OMA" id="DVNICEA"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="12"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="433"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87735.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="575" mass="65109" checksum="220F163C58FCF15A" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQP1</accession>
    <name>Q5CQP1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">T-complex protein 1 subunit eta</fullName>
            <shortName evidence="10">TCP-1-eta</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">CCT-eta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd4_3860</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 10">Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Heterooligomeric complex that forms two stacked rings.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625961.1">
        <property type="nucleotide sequence ID" value="XM_625961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQP1"/>
    <dbReference type="FunCoup" id="Q5CQP1">
        <property type="interactions" value="595"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQP1"/>
    <dbReference type="GeneID" id="3372933"/>
    <dbReference type="KEGG" id="cpv:cgd4_3860"/>
    <dbReference type="InParanoid" id="Q5CQP1"/>
    <dbReference type="OMA" id="HRKGNTW"/>
    <dbReference type="OrthoDB" id="1935484at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03340">
        <property type="entry name" value="TCP1_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000017">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.260.10:FF:000022">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000006">
        <property type="entry name" value="T-complex protein 1 subunit eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012720">
        <property type="entry name" value="Chap_CCT_eta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02345">
        <property type="entry name" value="chap_CCT_eta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 9" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="542"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="11">
        <location>
            <begin position="555"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00024677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK87917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="570" mass="62033" checksum="A8AEE09EE69A359E" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR01</accession>
    <name>Q5CR01_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Telomeric single stranded DNA binding POT1/Cdc13 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_2650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625851.1">
        <property type="nucleotide sequence ID" value="XM_625851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR01"/>
    <dbReference type="GeneID" id="3372836"/>
    <dbReference type="KEGG" id="cpv:cgd4_2650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2650"/>
    <dbReference type="InParanoid" id="Q5CR01"/>
    <dbReference type="OrthoDB" id="336495at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="626" mass="71962" checksum="B16813F10022528A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR39</accession>
    <name>Q5CR39_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_2230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625813.1">
        <property type="nucleotide sequence ID" value="XM_625813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR39"/>
    <dbReference type="GeneID" id="3372983"/>
    <dbReference type="KEGG" id="cpv:cgd4_2230"/>
    <dbReference type="InParanoid" id="Q5CR39"/>
    <dbReference type="OMA" id="ICMIQRI"/>
    <dbReference type="OrthoDB" id="407343at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="552" mass="62602" checksum="34FEF1973B5D1623" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR45</accession>
    <name>Q5CR45_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CDT1 Geminin-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625807.1">
        <property type="nucleotide sequence ID" value="XM_625807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR45"/>
    <dbReference type="GeneID" id="3372956"/>
    <dbReference type="KEGG" id="cpv:cgd4_2150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2150"/>
    <dbReference type="InParanoid" id="Q5CR45"/>
    <dbReference type="OMA" id="WYRINEN"/>
    <dbReference type="OrthoDB" id="341730at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000076">
        <property type="term" value="P:DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071163">
        <property type="term" value="P:DNA replication preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030174">
        <property type="term" value="P:regulation of DNA-templated DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08674">
        <property type="entry name" value="Cdt1_m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045173">
        <property type="entry name" value="Cdt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014939">
        <property type="entry name" value="CDT1_Gemini-bd-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28637">
        <property type="entry name" value="DNA REPLICATION FACTOR CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28637:SF1">
        <property type="entry name" value="DNA REPLICATION FACTOR CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08839">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01075">
        <property type="entry name" value="CDT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDT1 Geminin-binding" evidence="2">
        <location>
            <begin position="242"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="467"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="485"/>
            <end position="494"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="727" mass="84039" checksum="48EFEFDA635ED9C0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR51</accession>
    <name>Q5CR51_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd4_2080</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87942.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625801.1">
        <property type="nucleotide sequence ID" value="XM_625801.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR51"/>
    <dbReference type="STRING" id="353152.Q5CR51"/>
    <dbReference type="GeneID" id="3372758"/>
    <dbReference type="KEGG" id="cpv:cgd4_2080"/>
    <dbReference type="InParanoid" id="Q5CR51"/>
    <dbReference type="OMA" id="ICGFVEP"/>
    <dbReference type="OrthoDB" id="1924421at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF203">
        <property type="entry name" value="PALMITOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="54"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="173"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="129"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87942.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="359" mass="41463" checksum="4F9A8025E057FEC3" modified="2005-04-12" version="1" fragment="single">IYFLLLHIIFWGRFFEFGMNDSDNAFNKSKTPCCILEEDLENEIIRKNGFQKPFVALQILIWALFGSNILAYYTFVIPSLPLLLATIIGIISAILCIIVFTLGWKVTAINPGYSEEDSLFNSSNLNCSECKICHLFFEENSKHCKLCNKCIPRYDHHCKWLNTCIGEKNYRHFFLLLFFVTMLLIMIIIATISSIIMETINNNTYIYWNSRLYFWSPITFYTIGVLILAIDIPLLILNGHLFVLHCYLVFRGVTTYEYLTKIVIEDETSKNKPGICCCCNTDDFCRQIVSSVDWIVADRKKIAAKKNKIKEEKENTSKGESNYDNANIHNLVGLELSNIKQLDYEEQSISPARGSFRTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR58</accession>
    <name>Q5CR58_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Apicomplexan CP 15/60K like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87882.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625794.1">
        <property type="nucleotide sequence ID" value="XM_625794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR58"/>
    <dbReference type="SMR" id="Q5CR58"/>
    <dbReference type="GeneID" id="3372964"/>
    <dbReference type="KEGG" id="cpv:cgd4_2000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2000"/>
    <dbReference type="InParanoid" id="Q5CR58"/>
    <dbReference type="OrthoDB" id="341469at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041316">
        <property type="entry name" value="ISP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18161">
        <property type="entry name" value="ISP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISP1 C-terminal" evidence="2">
        <location>
            <begin position="380"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="281"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="162"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="281"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="331"/>
            <end position="348"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87882.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="487" mass="55697" checksum="D3DE47BD28A3424F" modified="2005-04-12" version="1">MFEFISEMFHSCCKLKKNQKNDEYIFILCPAPSDLEEEYIDQEGNVKKKKLEKIRGTARNIVDKEIVREWSGREIGSCICCHLIYEDEMNVYRADKYGRHIGKDHEEYEGSQTREENCVNSVGSLSSYGSRKHFSEEPNSADSNSTSISSDENNNAVENKSKKTKERRKLNINRSPSAIEKEIDEKEKNKKLKETKDANNKECSTISSDINNDIHNTNEKTTDNRNNKKPENTNLKNDEQIPLSDQKKYSKSSPLSKNQCPPKLGKRPPIKNELLAMNDQKNNSLKSSIPNSKKCSKKISSAPKNEFNKIILEKEKVESNSRDTHKDDKNQTGNNNSQQINHITSSSNSDKEMIDNNGEIKYEEEEMKFNKDISSKIIRHRALIGIQAEIILKDGSTTDCKVSFSDEEDDLSFICNDKVKAVPWSNIREIFTTKSELRMVNTRAAIFKDPTLIIALHLKDTGNCIPLKFNSKKGKEDFLNFALRMIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR76</accession>
    <name>Q5CR76_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_1820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87897.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625776.1">
        <property type="nucleotide sequence ID" value="XM_625776.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR76"/>
    <dbReference type="GeneID" id="3372903"/>
    <dbReference type="KEGG" id="cpv:cgd4_1820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1820"/>
    <dbReference type="InParanoid" id="Q5CR76"/>
    <dbReference type="OrthoDB" id="341175at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="630"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="413"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="497"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="633"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87897.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="651" mass="77053" checksum="184D6913BC575A24" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRC4</accession>
    <name>Q5CRC4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626262.1">
        <property type="nucleotide sequence ID" value="XM_626262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRC4"/>
    <dbReference type="GeneID" id="3373051"/>
    <dbReference type="KEGG" id="cpv:cgd5_3370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3370"/>
    <dbReference type="InParanoid" id="Q5CRC4"/>
    <dbReference type="OMA" id="VSENICW"/>
    <dbReference type="OrthoDB" id="344153at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="958"/>
            <end position="977"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1019" mass="116772" checksum="DCF9BE5B1782DB14" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRF0</accession>
    <name>Q5CRF0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_3040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626236.1">
        <property type="nucleotide sequence ID" value="XM_626236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRF0"/>
    <dbReference type="FunCoup" id="Q5CRF0">
        <property type="interactions" value="445"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRF0"/>
    <dbReference type="GeneID" id="3373213"/>
    <dbReference type="KEGG" id="cpv:cgd5_3040"/>
    <dbReference type="InParanoid" id="Q5CRF0"/>
    <dbReference type="OMA" id="AAYHKVQ"/>
    <dbReference type="OrthoDB" id="1724687at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000554">
        <property type="entry name" value="Ribosomal_eS7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11278:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01251">
        <property type="entry name" value="Ribosomal_S7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU364105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="204" mass="23050" checksum="44887696C23FC562" modified="2005-04-12" version="1" fragment="single">HTLTMKGKCIKKNDSPLTQLEKDVERCFQDIESSSNDEELKAIVQSVVFSTAKEIDCGSRKAVAVFVPYAIFMAYVRKIQGRIIAELEKKLKCPVVMIGQRSILPRNYRKYGFKSRPRSRTLTAVHDALLEDICGPSDIVGKRLRYRVDGSTLLKVILDPKDKDKDIADKVDVFGAVYKRLTNKEAEFSFPATNYYPGRLGIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRH9</accession>
    <name>Q5CRH9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87987.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626207.1">
        <property type="nucleotide sequence ID" value="XM_626207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRH9"/>
    <dbReference type="GeneID" id="3373225"/>
    <dbReference type="KEGG" id="cpv:cgd5_2700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2700"/>
    <dbReference type="InParanoid" id="Q5CRH9"/>
    <dbReference type="OrthoDB" id="343417at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253770" evidence="1">
        <location>
            <begin position="33"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87987.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="332" mass="38962" checksum="75B3297EA5195149" modified="2005-04-12" version="1">MNLIIGKGRKLSLHIMVLALILVIQLTQCVKCLDITRLNALLPGERYNLYTSLSKKRASFLELYLIEEEKNDEEGEPKVKVETDCMLSVLQYKLVDLLIGDRELNQNFDTITAKKCLRKSLSQLQSFYVRFFDLKLIYKPNCFERACFKKPEKVFFKNLENLALSMYFFFTVNNLIKEKGGFSRELALPQELEHKNEAISVLNNVNQLHSYKEGLKVCMKFNMLDIMLYPRLNNKTLLSEFKIFSSIVRILTANVEKHVRLYKYNKNNFEINGKKNYSKKLISDIKNIRSSMKLLSYVILTKYFIIADIFNLEIYEQIYNSIINTNTTYNAY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRM2</accession>
    <name>Q5CRM2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626164.1">
        <property type="nucleotide sequence ID" value="XM_626164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRM2"/>
    <dbReference type="STRING" id="353152.Q5CRM2"/>
    <dbReference type="GeneID" id="3373345"/>
    <dbReference type="KEGG" id="cpv:cgd5_2260"/>
    <dbReference type="InParanoid" id="Q5CRM2"/>
    <dbReference type="OMA" id="MNISKFW"/>
    <dbReference type="OrthoDB" id="344326at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="56"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="219"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="250"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="307" mass="37352" checksum="C34ACF57A29FADA6" modified="2005-04-12" version="1" fragment="single">FITFNNNSFKKEEEMNISKFWLLIAIILIYITSLEKDVEEKGLVKYSSQVSILELMKRKRGKSRNKKKKQKKQRKNKKSTRNDKKKSKKRVSTKEKRMKKKKINKRKQERMEKKMKQEEIKKEEELKRQKEQEKKREEELKKQKELEKKREEELKRQKRREEQERKKQERLQKKQAKEMENEAKENERKNLKEEKSKESVEQNKVKKDPFEKFKEMRNQARNNMLYNQHQAVNSDVDTDTTSEDIENDETLNSNNKGHLSQVKQVSSKSMISYPIKNQSKYESEDEGDEYEEDKNINTSKILKNYLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRN9</accession>
    <name>Q5CRN9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">SPAC694.02. SKI family SFII helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_2070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88062.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626147.1">
        <property type="nucleotide sequence ID" value="XM_626147.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRN9"/>
    <dbReference type="GeneID" id="3373261"/>
    <dbReference type="KEGG" id="cpv:cgd5_2070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2070"/>
    <dbReference type="InParanoid" id="Q5CRN9"/>
    <dbReference type="OMA" id="RRINCAD"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001039">
        <property type="entry name" value="ATP-dependent RNA helicase DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055124">
        <property type="entry name" value="PIN-like_DDX60"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052431">
        <property type="entry name" value="SKI2_subfamily_helicases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059032">
        <property type="entry name" value="WHD_DDX60"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533">
        <property type="entry name" value="DEAD/H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44533:SF4">
        <property type="entry name" value="DEAD_H RNA HELICASE, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23002">
        <property type="entry name" value="PIN-like_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26076">
        <property type="entry name" value="WHD_DDX60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="1062"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1539"/>
            <end position="1708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="677"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="753"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="941"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="677"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="769"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="948"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="960"/>
            <end position="973"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88062.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2123" mass="243225" checksum="907F73F31AEBA054" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRR5</accession>
    <name>Q5CRR5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RAB/RAS GTpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_1770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626121.1">
        <property type="nucleotide sequence ID" value="XM_626121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRR5"/>
    <dbReference type="STRING" id="353152.Q5CRR5"/>
    <dbReference type="GeneID" id="3373008"/>
    <dbReference type="KEGG" id="cpv:cgd5_1770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1770"/>
    <dbReference type="InParanoid" id="Q5CRR5"/>
    <dbReference type="OMA" id="MPMIYYK"/>
    <dbReference type="OrthoDB" id="299781at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="185" mass="21545" checksum="21AECF8083696A74" modified="2005-04-12" version="1">MFNYRVYYRTVRLPPEDSEIGDPISLCLEIEDLPGIESSYINDQFVNRYFNMARRELFIPPGTKDIIPFKIWRPPKVPLAAGQKYLPLTQGRMGFIFVCDINDIDSIKAIELLYQKFQSISELSISSIKPVVFLCANKVDKDTETKNFELNLFRIEDFASRMFIRLWKTSALTGKNIRHVSDKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRV5</accession>
    <name>Q5CRV5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">SPAC25G10.01-like RRM domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_1330</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88114.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626081.1">
        <property type="nucleotide sequence ID" value="XM_626081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRV5"/>
    <dbReference type="FunCoup" id="Q5CRV5">
        <property type="interactions" value="473"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRV5"/>
    <dbReference type="GeneID" id="3373293"/>
    <dbReference type="KEGG" id="cpv:cgd5_1330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1330"/>
    <dbReference type="InParanoid" id="Q5CRV5"/>
    <dbReference type="OMA" id="YKGVQNM"/>
    <dbReference type="OrthoDB" id="5970at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="71"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="140"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="169"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="179"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="202"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="241"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88114.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="253" mass="29614" checksum="6890821DBFCDA919" modified="2005-04-12" version="1">MPEAKKRGRKPIFRKMEEDNSEPQTCQAEEGNSQTQHELEQAEPIQEATNAESDEKNQVAPQIERSNDPSCTLYVCRLSLKTKEDDLRRLFEDYGEVTDCHLVTNPLSGESRCFGFVTMGNEEEAARAKDALDGKEYQDASLKVETARRAKPYDPTPGEYKGPQYRSIKYNSRTGYSRSSHRGNSFRHSTRSRYDYPPPSHSRGDQYNRHNDDYYNRYYDSRYPRPDDYHSSRYHSPPRYSRADPYDSRYSRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRW3</accession>
    <name>Q5CRW3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Tsr1p GTpase, multitransmembrane region protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_1240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Bms1-like GTPase family. TSR1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626073.1">
        <property type="nucleotide sequence ID" value="XM_626073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRW3"/>
    <dbReference type="FunCoup" id="Q5CRW3">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRW3"/>
    <dbReference type="GeneID" id="3373063"/>
    <dbReference type="KEGG" id="cpv:cgd5_1240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1240"/>
    <dbReference type="InParanoid" id="Q5CRW3"/>
    <dbReference type="OMA" id="MNLPRFK"/>
    <dbReference type="OrthoDB" id="119302at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000479">
        <property type="term" value="P:endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012948">
        <property type="entry name" value="AARP2CN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039761">
        <property type="entry name" value="Bms1/Tsr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007034">
        <property type="entry name" value="BMS1_TSR1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858:SF1">
        <property type="entry name" value="PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12858">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08142">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04950">
        <property type="entry name" value="RIBIOP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22298">
        <property type="entry name" value="Tsr1_G-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00785">
        <property type="entry name" value="AARP2CN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01362">
        <property type="entry name" value="DUF663"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AARP2CN" evidence="3">
        <location>
            <begin position="230"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome biogenesis protein BMS1/TSR1 C-terminal" evidence="4">
        <location>
            <begin position="418"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="750" mass="86749" checksum="FF9740FCC7ECF2B7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRZ2</accession>
    <name>Q5CRZ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pre-mRNA splicing factor Pro1/Prp6. HAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626044.1">
        <property type="nucleotide sequence ID" value="XM_626044.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRZ2"/>
    <dbReference type="FunCoup" id="Q5CRZ2">
        <property type="interactions" value="495"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRZ2"/>
    <dbReference type="GeneID" id="3373133"/>
    <dbReference type="KEGG" id="cpv:cgd5_920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_920"/>
    <dbReference type="InParanoid" id="Q5CRZ2"/>
    <dbReference type="OMA" id="DGWAWYY"/>
    <dbReference type="OrthoDB" id="440128at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000256">
        <property type="entry name" value="Probable pre-mRNA splicing factor prp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010491">
        <property type="entry name" value="PRP1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06424">
        <property type="entry name" value="PRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13428">
        <property type="entry name" value="TPR_14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PRP1 splicing factor N-terminal" evidence="6">
        <location>
            <begin position="28"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF06424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="923" mass="106144" checksum="70CEDFD8577BC49C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSI3</accession>
    <name>Q5CSI3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Arl1p/ARF like GTpase involved in vesicular transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_2580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628084.1">
        <property type="nucleotide sequence ID" value="XM_628084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSI3"/>
    <dbReference type="STRING" id="353152.Q5CSI3"/>
    <dbReference type="GeneID" id="3371692"/>
    <dbReference type="KEGG" id="cpv:cgd1_2580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2580"/>
    <dbReference type="InParanoid" id="Q5CSI3"/>
    <dbReference type="OMA" id="HIVDRNC"/>
    <dbReference type="OrthoDB" id="25466at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="247" mass="27828" checksum="9082A214938B017E" modified="2005-04-12" version="1">MKSLFSFDFLGKCNSRCFNILLTGPASSGRTTFLLRHLKGRYVDSATTENIYSAVIERENCVLNIVDKDIFSQSDNSYNCTLKIKNRNEIDKNGCIVKKKGKDKMQIIGKDTINDEDNSNIDGILFFIDSSDHGRIPLARRLLMQLLKKANKQTPILIIATRQDIIGALAPGELAAKLKIEDIASMFEDQAWDYGIIGVSAYTGLGCNEALDWISEAIWRHQLLCHCIPFNRFCYNLCNSGILMLNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSI6</accession>
    <name>Q5CSI6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Copper transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_2550</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628081.1">
        <property type="nucleotide sequence ID" value="XM_628081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSI6"/>
    <dbReference type="STRING" id="353152.Q5CSI6"/>
    <dbReference type="GeneID" id="3371695"/>
    <dbReference type="KEGG" id="cpv:cgd1_2550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2550"/>
    <dbReference type="InParanoid" id="Q5CSI6"/>
    <dbReference type="OMA" id="CCHSAKS"/>
    <dbReference type="OrthoDB" id="161814at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005375">
        <property type="term" value="F:copper ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007274">
        <property type="entry name" value="Cop_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483:SF27">
        <property type="entry name" value="COPPER TRANSPORT PROTEIN CTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12483">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 31 COPPER TRANSPORTERS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04145">
        <property type="entry name" value="Ctr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0186">Copper</keyword>
    <keyword evidence="5" id="KW-0187">Copper transport</keyword>
    <keyword evidence="5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="70"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="108"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU367022"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="178" mass="20477" checksum="804F154F2846F151" modified="2005-04-12" version="1">MCCSSKQNAIRLIKDTHGVHSAIIQDPTKDDLNQINNKSLLSIAMQMTFHQSFESVILFESWRTSNRFDYFISCLFIILMGCFTMFISSINKKYIKEIKKNRVEHENLGIKVICTNVLLTILYYFMHYLLMLIAMTFNWGLFFSVIIGLSIGYGIFELGSITKNECSCNNDCDLPSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSS3</accession>
    <name>Q5CSS3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Dynein intermediate chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_1540</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627994.1">
        <property type="nucleotide sequence ID" value="XM_627994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSS3"/>
    <dbReference type="FunCoup" id="Q5CSS3">
        <property type="interactions" value="130"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSS3"/>
    <dbReference type="GeneID" id="3371612"/>
    <dbReference type="KEGG" id="cpv:cgd1_1540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1540"/>
    <dbReference type="InParanoid" id="Q5CSS3"/>
    <dbReference type="OMA" id="MHDRPEY"/>
    <dbReference type="OrthoDB" id="4189at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005868">
        <property type="term" value="C:cytoplasmic dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045504">
        <property type="term" value="F:dynein heavy chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045503">
        <property type="term" value="F:dynein light chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010970">
        <property type="term" value="P:transport along microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050687">
        <property type="entry name" value="Dynein_IC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442:SF22">
        <property type="entry name" value="CYTOPLASMIC DYNEIN 1 INTERMEDIATE CHAIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12442">
        <property type="entry name" value="DYNEIN INTERMEDIATE CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="497"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="658"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="658"/>
            <end position="667"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="677" mass="74815" checksum="5518FCDF4F10D8B8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CST1</accession>
    <name>Q5CST1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted secreted protein, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627986.1">
        <property type="nucleotide sequence ID" value="XM_627986.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CST1"/>
    <dbReference type="STRING" id="353152.Q5CST1"/>
    <dbReference type="GeneID" id="3371619"/>
    <dbReference type="KEGG" id="cpv:cgd1_1450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1450"/>
    <dbReference type="InParanoid" id="Q5CST1"/>
    <dbReference type="OMA" id="IDICITH"/>
    <dbReference type="OrthoDB" id="340633at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254207" evidence="1">
        <location>
            <begin position="22"/>
            <end position="785"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="785" mass="90800" checksum="CB42AA909A6AE618" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSV9</accession>
    <name>Q5CSV9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_1130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF-assemblin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627958.1">
        <property type="nucleotide sequence ID" value="XM_627958.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSV9"/>
    <dbReference type="GeneID" id="3371598"/>
    <dbReference type="KEGG" id="cpv:cgd1_1130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1130"/>
    <dbReference type="InParanoid" id="Q5CSV9"/>
    <dbReference type="OMA" id="EHTANDM"/>
    <dbReference type="OrthoDB" id="436841at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008374">
        <property type="entry name" value="SF_assemblin/giardin_b"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06705">
        <property type="entry name" value="SF-assemblin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="237" mass="27446" checksum="04E2066ABBE929F2" modified="2005-04-12" version="1">MIENQLSCSSAGKMKEIIKIQEQLRDEVLECIQSRKSKMAELQSETEELGNQMIQEVTMKVLHRIELIMNTLESILCRCEKVEAKFISYKRDSNSKSQQVGELAERFESVKHELKHYFVIIERIAGIFSETNHLNNQMIKTINDKLSRLSCNNSHIPIQEQIQKFHENFENNSKLNVFNPNNQFSNFVLQEFKSIQNAINSTSKLRQEADDSIANAMKEFTDTLQNGLKIAVSHSKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSZ7</accession>
    <name>Q5CSZ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627920.1">
        <property type="nucleotide sequence ID" value="XM_627920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSZ7"/>
    <dbReference type="GeneID" id="3371537"/>
    <dbReference type="KEGG" id="cpv:cgd1_690"/>
    <dbReference type="InParanoid" id="Q5CSZ7"/>
    <dbReference type="OrthoDB" id="341166at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="251" mass="28690" checksum="F11CEF6B39D1B100" modified="2005-04-12" version="1">MNGEKSFKDLETLVSRYIKLNMSEERGEGEEEGGTRRRKGRSGEEEEEKIFIDSFELCKGAKSIRNKRRKIEDSNSSYTNSENLNHRKLTGTIAQYLLSRVPLPTSRVDIQKKFIKPEGSKKIDLDSILNTINDKFKSCMGLGIFGLDKSITNQTSSNPKYYVVQLNRSKAHLDLVYQFGNIDFKSIGELTINQDENHLVSNRLCNSFLTFLSFIYGFFEITSSDEDLIQDDEDSSKIIQSNEEIEIPIGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT49</accession>
    <name>Q5CT49_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_50</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627868.1">
        <property type="nucleotide sequence ID" value="XM_627868.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT49"/>
    <dbReference type="STRING" id="353152.Q5CT49"/>
    <dbReference type="GeneID" id="3371441"/>
    <dbReference type="KEGG" id="cpv:cgd1_50"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_50"/>
    <dbReference type="InParanoid" id="Q5CT49"/>
    <dbReference type="OMA" id="SFMLNLH"/>
    <dbReference type="OrthoDB" id="64915at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038375">
        <property type="entry name" value="NDUFAF7_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="1">
        <location>
            <begin position="535"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="956" mass="109514" checksum="7AB27A7EE3D30A47" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTB9</accession>
    <name>Q5CTB9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626550.1">
        <property type="nucleotide sequence ID" value="XM_626550.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTB9"/>
    <dbReference type="STRING" id="353152.Q5CTB9"/>
    <dbReference type="GeneID" id="3373621"/>
    <dbReference type="KEGG" id="cpv:cgd2_3630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3630"/>
    <dbReference type="InParanoid" id="Q5CTB9"/>
    <dbReference type="OrthoDB" id="342507at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="426"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="34"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="202"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="233"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="261"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="426"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="465"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="480"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="492" mass="55734" checksum="8920CEEDCC604180" modified="2005-04-12" version="1">MEGVKYSRGGKVHVGEERSRGGRGGYVGMFVDGKGNGRGGGTYRGNRFSRGNKTKSGSIYRDQNTKLDFTRKLQSSTETTVGPDELEKSSASADCSNKVVVDTSDLLASSFRIPPEKKCDEKIGVIPNGISSTEASEYCKSQGSSQNPSPLGGCQEKFNTSSNFYGDSKHFSNYKHYKKNHFQSAYRGRRKMFNKTQGEKALEMNREPEKQDLTSPTPSPVEPAQIEGVESINTKKDEPKLPTSDKKIPSQEDILESPSKMPDKNSKCTETLIKDQDNNINSNSQMIRDVINWMKERQGEAIQWLKENGKYPQEEYVQNSVRKPRKFSQDGGFREKKQSWNGSERNIEEKNQRFPAKYKGQKKDTPSSYSPKTLVNPTNQDKSSNSTSECLELSKCRETSKQFGANIPNKDLGQKLDLRAKQKFEYNRRFSREKTGNFHFQNKTKEDESRRSTGTINDSKDGEKSTNSNSNFNTPTKYRNQYHKKQSVQKDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTH4</accession>
    <name>Q5CTH4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Vesicle-fusing ATPase</fullName>
            <ecNumber evidence="6">3.6.4.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_3010</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="6">Binds 1 Mg(2+) ion per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.6" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626495.1">
        <property type="nucleotide sequence ID" value="XM_626495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTH4"/>
    <dbReference type="FunCoup" id="Q5CTH4">
        <property type="interactions" value="174"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTH4"/>
    <dbReference type="GeneID" id="3373457"/>
    <dbReference type="KEGG" id="cpv:cgd2_3010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3010"/>
    <dbReference type="InParanoid" id="Q5CTH4"/>
    <dbReference type="OMA" id="VINWGTP"/>
    <dbReference type="OrthoDB" id="9982946at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005795">
        <property type="term" value="C:Golgi stack"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043001">
        <property type="term" value="P:Golgi to plasma membrane protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035494">
        <property type="term" value="P:SNARE complex disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000115">
        <property type="entry name" value="N-ethylmaleimide-sensitive fusion protein, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000154">
        <property type="entry name" value="Vesicle-fusing ATPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000166">
        <property type="entry name" value="vesicle-fusing ATPase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039812">
        <property type="entry name" value="Vesicle-fus_ATPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078:SF3">
        <property type="entry name" value="VESICLE-FUSING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23078">
        <property type="entry name" value="VESICULAR-FUSION PROTEIN NSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="262"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="543"/>
            <end position="679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="747" mass="82530" checksum="D00102E564071F99" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTK5</accession>
    <name>Q5CTK5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626464.1">
        <property type="nucleotide sequence ID" value="XM_626464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTK5"/>
    <dbReference type="GeneID" id="3373638"/>
    <dbReference type="KEGG" id="cpv:cgd2_2620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2620"/>
    <dbReference type="InParanoid" id="Q5CTK5"/>
    <dbReference type="OMA" id="TNWLINI"/>
    <dbReference type="OrthoDB" id="338777at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="599" mass="71257" checksum="4EE6FCDFDC8EBCE5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTT1</accession>
    <name>Q5CTT1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apicomplexan small protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_1690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626388.1">
        <property type="nucleotide sequence ID" value="XM_626388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTT1"/>
    <dbReference type="FunCoup" id="Q5CTT1">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="3373678"/>
    <dbReference type="KEGG" id="cpv:cgd2_1690"/>
    <dbReference type="InParanoid" id="Q5CTT1"/>
    <dbReference type="OMA" id="YMFSEFY"/>
    <dbReference type="OrthoDB" id="439796at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="100" mass="11264" checksum="8147B20BA16C4076" modified="2005-04-12" version="1" fragment="single">TMSVVSYSRFLDSAIMGIFTICLSGLTLYLFGEFWGLCQSPPLSKWSIGKIMSTLFPFKRTFDVNLTHILLFSIIICLLSLRSDQGTNSSKCGQKQKRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTX8</accession>
    <name>Q5CTX8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Syntaxin, putative, SMART syntaxin+tSNARE+transmembrane domain or GPI anchor at C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_1140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the syntaxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626341.1">
        <property type="nucleotide sequence ID" value="XM_626341.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTX8"/>
    <dbReference type="FunCoup" id="Q5CTX8">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTX8"/>
    <dbReference type="GeneID" id="3373588"/>
    <dbReference type="KEGG" id="cpv:cgd2_1140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1140"/>
    <dbReference type="InParanoid" id="Q5CTX8"/>
    <dbReference type="OMA" id="RWICFIL"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006887">
        <property type="term" value="P:exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048278">
        <property type="term" value="P:vesicle docking"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15848">
        <property type="entry name" value="SNARE_syntaxin1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045242">
        <property type="entry name" value="Syntaxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006012">
        <property type="entry name" value="Syntaxin/epimorphin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006011">
        <property type="entry name" value="Syntaxin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957:SF307">
        <property type="entry name" value="PROTEIN SSO1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19957">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05739">
        <property type="entry name" value="SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00804">
        <property type="entry name" value="Syntaxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00397">
        <property type="entry name" value="t_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00914">
        <property type="entry name" value="SYNTAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="295"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="8">
        <location>
            <begin position="222"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="110"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="225"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="322" mass="37015" checksum="8672F3D11DCCB60E" modified="2005-04-12" version="1">MIDLLYDLRKYAVAKHPEFSAAISNAEKGVAQVGVDQGVNEQNGNSKNDEEMSSYYSEIRSIGVSLGYINKMIDGIRINKQRALLTTSSSKDEEISENLAKILDETHEKTLELKNNIEYLRIQNENLKKKASKKEATEIMIRENLLQTISKRFRETIYEFQSVQSEYKTEMRNKIFRQIKIVYPDATQSAIESIAEEEGKITTTQLIKMKLSGSHETIGNAITELQDRYRDIRKLEKSVEELQQLFIELASLINEQGEMLDHIEFSVSTAKDYTEKADIELISARKYQKKTQKKMLWIILCIFILILVVLLPIIIGFTIESS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU21</accession>
    <name>Q5CU21_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd2_620</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SEC61-beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626298.1">
        <property type="nucleotide sequence ID" value="XM_626298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU21"/>
    <dbReference type="STRING" id="353152.Q5CU21"/>
    <dbReference type="GeneID" id="3373655"/>
    <dbReference type="KEGG" id="cpv:cgd2_620"/>
    <dbReference type="InParanoid" id="Q5CU21"/>
    <dbReference type="OMA" id="AYMSIVI"/>
    <dbReference type="OrthoDB" id="5401193at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005784">
        <property type="term" value="C:Sec61 translocon complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030671">
        <property type="entry name" value="Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016482">
        <property type="entry name" value="SecG/Sec61-beta/Sbh"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13509">
        <property type="entry name" value="SEC61 SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03911">
        <property type="entry name" value="Sec61_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="35"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="66" mass="7371" checksum="E73930CE9A30F3C7" modified="2005-04-12" version="1" fragment="single">IRQRRALASSVTSSRENLAQNLMSYYVDDTPGLKLGPMTVLVMTLAYMSIVIVLHILGKFKEKIMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU34</accession>
    <name>Q5CU34_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626285.1">
        <property type="nucleotide sequence ID" value="XM_626285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU34"/>
    <dbReference type="GeneID" id="3373687"/>
    <dbReference type="KEGG" id="cpv:cgd2_480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_480"/>
    <dbReference type="InParanoid" id="Q5CU34"/>
    <dbReference type="OMA" id="WEINLAS"/>
    <dbReference type="OrthoDB" id="344157at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.160.10">
        <property type="entry name" value="Porin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023614">
        <property type="entry name" value="Porin_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="471" mass="52385" checksum="AB4E7FEA17E50A70" modified="2005-04-12" version="1">MVLVGDFNKEVIGLFKSKYPTEKDKLLELNLTSICKNPSFSYNISTPSNGGKNGNKSKCCNDGNGCCGENNSNNNSKQIFSLDGNSTLKWNICSSQMETKMDMNGISIMEVKTKPYYGISLTSKYERFPKLTNSLGSYNNTNNGSGCLEIGGDIQGEYIQSRFRISPTIKTLGCLNKSNKENKDSIGMMLSNTITLRPFSCINSLSLGSMISSSNINLPHNNNNKNSLKLMLGLMLKGPLFMRSCKDTINERSQGYEQFNYQGLIHKKENFGSRFKNSMICNNNNTNDNNDLYEGIGGSSTLSPISILTPNYVLSLQTNTNHQNNKLSGFTGGLILNNLVRNYLTLGLMISYNTENNNGNNNEDNIQQIEDNGLGLITKNKVSKTYYENYLTKFSDKVQYTIGGKISFGSMTNNMKSTDLRFKVMNNLKMAYSLTHNFTKNISATFGAQIDPRKLNDPDSVKYGFILDMSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU78</accession>
    <name>Q5CU78_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_3900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626936.1">
        <property type="nucleotide sequence ID" value="XM_626936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU78"/>
    <dbReference type="STRING" id="353152.Q5CU78"/>
    <dbReference type="GeneID" id="3373848"/>
    <dbReference type="KEGG" id="cpv:cgd3_3900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3900"/>
    <dbReference type="InParanoid" id="Q5CU78"/>
    <dbReference type="OMA" id="TNECRIC"/>
    <dbReference type="OrthoDB" id="341422at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="255"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="256"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="266"/>
            <end position="287"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1007" mass="112308" checksum="177A00CC186816A5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU85</accession>
    <name>Q5CU85_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA ligase</fullName>
            <ecNumber evidence="14">6.5.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd3_3820</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho-(deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + diphosphate.</text>
            <dbReference type="EC" id="6.5.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the ATP-dependent DNA ligase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.5.1.1" evidence="14"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626929.1">
        <property type="nucleotide sequence ID" value="XM_626929.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU85"/>
    <dbReference type="FunCoup" id="Q5CU85">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU85"/>
    <dbReference type="GeneID" id="3373851"/>
    <dbReference type="KEGG" id="cpv:cgd3_3820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3820"/>
    <dbReference type="InParanoid" id="Q5CU85"/>
    <dbReference type="OMA" id="WIKYKRD"/>
    <dbReference type="OrthoDB" id="206088at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003910">
        <property type="term" value="F:DNA ligase (ATP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071897">
        <property type="term" value="P:DNA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006273">
        <property type="term" value="P:lagging strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07900">
        <property type="entry name" value="Adenylation_DNA_ligase_I_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07969">
        <property type="entry name" value="OBF_DNA_ligase_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000062">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.30:FF:000002">
        <property type="entry name" value="DNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3260.10">
        <property type="entry name" value="DNA ligase, ATP-dependent, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050191">
        <property type="entry name" value="ATP-dep_DNA_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000977">
        <property type="entry name" value="DNA_ligase_ATP-dep"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012309">
        <property type="entry name" value="DNA_ligase_ATP-dep_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012310">
        <property type="entry name" value="DNA_ligase_ATP-dep_cent"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016059">
        <property type="entry name" value="DNA_ligase_ATP-dep_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012308">
        <property type="entry name" value="DNA_ligase_ATP-dep_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036599">
        <property type="entry name" value="DNA_ligase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00574">
        <property type="entry name" value="dnl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674:SF4">
        <property type="entry name" value="DNA LIGASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45674">
        <property type="entry name" value="DNA LIGASE 1/3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04679">
        <property type="entry name" value="DNA_ligase_A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01068">
        <property type="entry name" value="DNA_ligase_A_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04675">
        <property type="entry name" value="DNA_ligase_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117018">
        <property type="entry name" value="ATP-dependent DNA ligase DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00697">
        <property type="entry name" value="DNA_LIGASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00333">
        <property type="entry name" value="DNA_LIGASE_A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50160">
        <property type="entry name" value="DNA_LIGASE_A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 14" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9 14" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="10 14" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 14 18" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATP-dependent DNA ligase family profile" evidence="17">
        <location>
            <begin position="544"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="73"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="73"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="104"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU000617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU004196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAK88972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="825" mass="93061" checksum="1B9BD6A63ABAF8CA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUC7</accession>
    <name>Q5CUC7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2-(3-amino-3-carboxypropyl)histidine synthase subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_3360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626887.1">
        <property type="nucleotide sequence ID" value="XM_626887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUC7"/>
    <dbReference type="FunCoup" id="Q5CUC7">
        <property type="interactions" value="99"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUC7"/>
    <dbReference type="GeneID" id="3374125"/>
    <dbReference type="KEGG" id="cpv:cgd3_3360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3360"/>
    <dbReference type="InParanoid" id="Q5CUC7"/>
    <dbReference type="OMA" id="IEMYILL"/>
    <dbReference type="OrthoDB" id="361972at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090560">
        <property type="term" value="F:2-(3-amino-3-carboxypropyl)histidine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11840">
        <property type="entry name" value="Diphthamide synthesis DPH1/DPH2 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016435">
        <property type="entry name" value="DPH1/DPH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042263">
        <property type="entry name" value="DPH1/DPH2_1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00322">
        <property type="entry name" value="diphth2_R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762:SF2">
        <property type="entry name" value="2-(3-AMINO-3-CARBOXYPROPYL)HISTIDINE SYNTHASE SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10762">
        <property type="entry name" value="DIPHTHAMIDE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01866">
        <property type="entry name" value="Diphthamide_syn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00032">
        <property type="entry name" value="Radical_SAM_3-amino-3-carboxyp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="551" mass="63573" checksum="0C83A74C86E8A428" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUC9</accession>
    <name>Q5CUC9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SECIS binding protein. pelota RNA binding domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_3340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626885.1">
        <property type="nucleotide sequence ID" value="XM_626885.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUC9"/>
    <dbReference type="GeneID" id="3373865"/>
    <dbReference type="KEGG" id="cpv:cgd3_3340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3340"/>
    <dbReference type="InParanoid" id="Q5CUC9"/>
    <dbReference type="OrthoDB" id="263617at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003730">
        <property type="term" value="F:mRNA 3'-UTR binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035368">
        <property type="term" value="F:selenocysteine insertion sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040051">
        <property type="entry name" value="SECISBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13284:SF4">
        <property type="entry name" value="C2H2-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13284">
        <property type="entry name" value="GH01354P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="2">
        <location>
            <begin position="1320"/>
            <end position="1395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="182"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1088"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="36"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="182"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1064"/>
            <end position="1088"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1445" mass="156249" checksum="D488D1C84EEF5912" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUF6</accession>
    <name>Q5CUF6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_3010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626858.1">
        <property type="nucleotide sequence ID" value="XM_626858.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3374094"/>
    <dbReference type="KEGG" id="cpv:cgd3_3010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3010"/>
    <dbReference type="InParanoid" id="Q5CUF6"/>
    <dbReference type="OMA" id="FIASECI"/>
    <dbReference type="OrthoDB" id="340646at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2421" mass="282505" checksum="EE696F61C2508ADD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUR9</accession>
    <name>Q5CUR9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Signal peptide containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89121.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626745.1">
        <property type="nucleotide sequence ID" value="XM_626745.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUR9"/>
    <dbReference type="GeneID" id="3374164"/>
    <dbReference type="KEGG" id="cpv:cgd3_1730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1730"/>
    <dbReference type="InParanoid" id="Q5CUR9"/>
    <dbReference type="OrthoDB" id="343597at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254973" description="Signal peptide containing protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89121.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="298" mass="32978" checksum="FA0809977F06AE00" modified="2005-04-12" version="1">MLMSSSIINFLLVLLFTVSSTSNNFVKNFILEVSFLNAASLETGSEGEPVALPQQDAQKPQFGVLQGRGSTVLSDFMTSNGVGLDLSVNKKCSKGELQKLLKLLENTMLTLFEIHGKSVGLEKTINEQTHSSNLEISRLNDLRAKEISLNEKLEQLLAEIFSCLLRMAAKRYSGKSIRTNEKGCTILSVTYFSALKSASEAILAVLKKVLKELTKLYNKCLTSVHIDPNSCRCYGFSLSSAQDSFSAQKQISKNSASEKIKCKRYVRNKITTRLLGGIRARASGETVFEDEQEVNTYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV14</accession>
    <name>Q5CV14_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626650.1">
        <property type="nucleotide sequence ID" value="XM_626650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV14"/>
    <dbReference type="GeneID" id="3374144"/>
    <dbReference type="KEGG" id="cpv:cgd3_650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_650"/>
    <dbReference type="InParanoid" id="Q5CV14"/>
    <dbReference type="OMA" id="RDICEAC"/>
    <dbReference type="OrthoDB" id="341330at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253883" evidence="2">
        <location>
            <begin position="23"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="863" mass="99919" checksum="F80D9A003A0FA6CD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV16</accession>
    <name>Q5CV16_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_630</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89197.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626648.1">
        <property type="nucleotide sequence ID" value="XM_626648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV16"/>
    <dbReference type="GeneID" id="3374143"/>
    <dbReference type="KEGG" id="cpv:cgd3_630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_630"/>
    <dbReference type="InParanoid" id="Q5CV16"/>
    <dbReference type="OMA" id="ELECEKD"/>
    <dbReference type="OrthoDB" id="344082at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254261" evidence="2">
        <location>
            <begin position="28"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89197.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="315" mass="37404" checksum="850B0242209244D8" modified="2005-04-12" version="1">MKMHIIKFGRLFLPILVIFSFVWLSESVRLENYEILAEDQIAEIENSQKQNNDQVCEINTIGESCSGRILKLKSNIQQGVVLNIKTEFSLISNDNSTQISESSSISKAKLSLRNNQRNEIKNSANIDLHSEIYNPIQGKEKEKSEKKTDDEKKTENEKKDEKEKDEKKMEEEKERKKKVEEGKKTENEKYKKKVEDEKMAENEKDEKKTDEEKKTDNEKDEKKVEDEKMAENEKDEKKTEEEKKTDEEKKTENEKKDEKKTENEKDEKKVEDKKMAENEKKYEKKTEEEKDKKEMDEKVEEKKKTEKEDEKKRKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV21</accession>
    <name>Q5CV21_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626643.1">
        <property type="nucleotide sequence ID" value="XM_626643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV21"/>
    <dbReference type="GeneID" id="3373792"/>
    <dbReference type="KEGG" id="cpv:cgd3_580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_580"/>
    <dbReference type="InParanoid" id="Q5CV21"/>
    <dbReference type="OMA" id="TFECDEL"/>
    <dbReference type="OrthoDB" id="341395at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254264" evidence="2">
        <location>
            <begin position="24"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="603"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="688" mass="81102" checksum="76543C5CABC05AC9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV27</accession>
    <name>Q5CV27_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cysteine-rich extracellular protein with a signal peptide and two apple domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626637.1">
        <property type="nucleotide sequence ID" value="XM_626637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV27"/>
    <dbReference type="STRING" id="353152.Q5CV27"/>
    <dbReference type="GeneID" id="3373798"/>
    <dbReference type="KEGG" id="cpv:cgd3_520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_520"/>
    <dbReference type="InParanoid" id="Q5CV27"/>
    <dbReference type="OMA" id="ANIFYKI"/>
    <dbReference type="OrthoDB" id="336094at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14295">
        <property type="entry name" value="PAN_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00223">
        <property type="entry name" value="APPLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="385"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="683" mass="75870" checksum="71CBF035B2FB9CE8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV80</accession>
    <name>Q5CV80_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_5090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627389.1">
        <property type="nucleotide sequence ID" value="XM_627389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV80"/>
    <dbReference type="GeneID" id="3374228"/>
    <dbReference type="KEGG" id="cpv:cgd8_5090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5090"/>
    <dbReference type="InParanoid" id="Q5CV80"/>
    <dbReference type="OrthoDB" id="342594at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="306" mass="35798" checksum="6E155EA013B80AAC" modified="2005-04-12" version="1">MKETQDESKMWSGTRNNDFEISPEIKEQSQTLSQQKHSKRVKNCLTYLLVAAFTTIALILIFVIFDKNGRNPIQVYFQGVFPSKSGEREIFNPSLQKVADGHSFMEKSVTSEYDNGSEKSNKIAHTYDSGHYQSVLELYMNRLFVTPLNKMSLTVPINDQVLRSYQVEAIDYSIDDEMILYLSLEHQLKINNETMVLYDKSMNVISHFPTYEDEEGTEKKNIKQGSNNQKSSNTENKLRNNENKRHLQQLQQHEYYNYTSTSEWNHKPEVVNNIIPTYYPRNPYVPPYGNPYYFAPNILVPYVYIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVC5</accession>
    <name>Q5CVC5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627344.1">
        <property type="nucleotide sequence ID" value="XM_627344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVC5"/>
    <dbReference type="FunCoup" id="Q5CVC5">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="GeneID" id="3374443"/>
    <dbReference type="KEGG" id="cpv:cgd8_4590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4590"/>
    <dbReference type="InParanoid" id="Q5CVC5"/>
    <dbReference type="OMA" id="AYIMEHY"/>
    <dbReference type="OrthoDB" id="16729at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="59"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="224" mass="26294" checksum="492ECBDCC817C1C1" modified="2005-04-12" version="1">MAEVIDIEEFLNSIERRIQKCENIISSKKEDFRNNYDQGVSNKSKENNSLTPTIQNRLAVGQNSLMANLENEIQELDKVKDDQSYSINYKLDCIESIIKKIFSLGPLENWLSTYETIKAYLEMDSADFESSVLTLDLRKAYIMEHFDEFNTMKSQLIELENLLPFLNQEIDIQSINDTGKRLKDLENRSKRISNETKLLWENLEKLVFSYSNFVYKYNILTLNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVG3</accession>
    <name>Q5CVG3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627306.1">
        <property type="nucleotide sequence ID" value="XM_627306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVG3"/>
    <dbReference type="GeneID" id="3374191"/>
    <dbReference type="KEGG" id="cpv:cgd8_4160"/>
    <dbReference type="InParanoid" id="Q5CVG3"/>
    <dbReference type="OMA" id="REVHNIG"/>
    <dbReference type="OrthoDB" id="339750at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="370" mass="42442" checksum="6A7C2911F428EF7F" modified="2005-04-12" version="1">MLASTGIQPYFEAPSILICPITVPDVTGNQIFNKRGVNDEIEFLDDNQFFLVLRSQGILGYKKAPVRRCGRNCLCFETNQGDFTSLDNQTLDKHPIEDTFIMKTSKTRGKSSSDITELNLSGRLDVDYLELWMFHKHLDPNKRIVKVGLYGNNTPLVHGDFPKTATWHIMKLGDITLFLLRLIRFRSEEFSLYHIMDLILFFLPNKVNKHNSSFYMYNIHSGHFINPSLNNENFVNAINRIKLATREDINIEQDSNSLTVLHLEASSKFIKEVYKIGQSMSIAAFFGCLVILIVLVNNVGVFKLCFKRRIINEEDSNDEIKPKLCVSAPVKAISCYLLSENHQDDHKYKVHNNQDECKMPINLESINTLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVS6</accession>
    <name>Q5CVS6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Eft2p GTpase translation elongation factor 2 (EF-2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_2930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89704.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627193.1">
        <property type="nucleotide sequence ID" value="XM_627193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVS6"/>
    <dbReference type="FunCoup" id="Q5CVS6">
        <property type="interactions" value="419"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVS6"/>
    <dbReference type="GeneID" id="3374334"/>
    <dbReference type="KEGG" id="cpv:cgd8_2930"/>
    <dbReference type="InParanoid" id="Q5CVS6"/>
    <dbReference type="OMA" id="ASWNTEN"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01681">
        <property type="entry name" value="aeEF2_snRNP_like_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16268">
        <property type="entry name" value="EF2_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16261">
        <property type="entry name" value="EF2_snRNP_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000010">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000006">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000003">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000058">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF10">
        <property type="entry name" value="EUKARYOTIC TRANSLATION ELONGATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="8">
        <location>
            <begin position="21"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="584"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="597"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89704.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="836" mass="93274" checksum="0FECF53089AB9CE3" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVS8</accession>
    <name>Q5CVS8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ferlin-like type II membrane associated protein with 5 C2 domains, transmembrane domain or GPI anchor at C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_2910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627191.1">
        <property type="nucleotide sequence ID" value="XM_627191.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVS8"/>
    <dbReference type="GeneID" id="3374325"/>
    <dbReference type="KEGG" id="cpv:cgd8_2910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2910"/>
    <dbReference type="InParanoid" id="Q5CVS8"/>
    <dbReference type="OMA" id="HIPTCTP"/>
    <dbReference type="OrthoDB" id="270970at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007009">
        <property type="term" value="P:plasma membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012968">
        <property type="entry name" value="FerIin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037721">
        <property type="entry name" value="Ferlin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032362">
        <property type="entry name" value="Ferlin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546">
        <property type="entry name" value="FER-1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12546:SF33">
        <property type="entry name" value="SPERM VESICLE FUSION PROTEIN FER-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16165">
        <property type="entry name" value="Ferlin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM01202">
        <property type="entry name" value="FerI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1350"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="157"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="470"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="7">
        <location>
            <begin position="1141"/>
            <end position="1265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1371" mass="154368" checksum="525C0A89B0C5080B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVV1</accession>
    <name>Q5CVV1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical secreted protein, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89456.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627168.1">
        <property type="nucleotide sequence ID" value="XM_627168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVV1"/>
    <dbReference type="GeneID" id="3374385"/>
    <dbReference type="KEGG" id="cpv:cgd8_2680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2680"/>
    <dbReference type="InParanoid" id="Q5CVV1"/>
    <dbReference type="OrthoDB" id="340356at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254293" evidence="1">
        <location>
            <begin position="25"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89456.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="298" mass="34341" checksum="AAA5BDF5E404D9AA" modified="2005-04-12" version="1">MKNLKYKFLLFIAISLLFISKVKSSRIIYLDENATRLESNATEPISNNKFPYLPNISNDTFNNMQENIIKAVVGFDSFIFDIAKNITSGMRIAQFFILNKTKTFILPFVMFPDEKSFENFKNSTSNETEVDNLKLEKLFPININLLSPNKSNFTNSTLEETLIKPEMLIPYLRGSHKTIRYNDTTNENLKNFTTVNSTDDSEKIINSTLIRLNKYLLTPNNGSLNINNQTSRLRFLQFTSAYGLEDISDQQFGQDLNYLDGIPNVGGISSFAQDYDQWIPSNNFDFYNGYGFDFLFME</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVV5</accession>
    <name>Q5CVV5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Conserved metal binding motif protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_2640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627164.1">
        <property type="nucleotide sequence ID" value="XM_627164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVV5"/>
    <dbReference type="GeneID" id="3374380"/>
    <dbReference type="KEGG" id="cpv:cgd8_2640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2640"/>
    <dbReference type="InParanoid" id="Q5CVV5"/>
    <dbReference type="OMA" id="DSTCITH"/>
    <dbReference type="OrthoDB" id="26899at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16651">
        <property type="entry name" value="SPL-RING_NSE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004181">
        <property type="entry name" value="Znf_MIZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11789">
        <property type="entry name" value="zf-Nse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SP-RING-type" evidence="4">
        <location>
            <begin position="105"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="204" mass="23939" checksum="EAE02C3907117755" modified="2005-04-12" version="1">MDDILRNYLNSLNGLSIKYDSLSEKYKLGENLSQDERKKLYELFVSFERMKLWIKSVLYGENDQQFENFNSPSAEFEYFKEMLMARLELTCNTRRNKEKDQVSVVSRKVLPKVCCLTRDVFKDPVSHRYDTSEKVENMCKNHIYEKDALLKYLGSSKKKICPIAGCNFLVVKKFLKRDQEVLDQIQCDSAVKSEVQEGIQNLLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWD7</accession>
    <name>Q5CWD7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626982.1">
        <property type="nucleotide sequence ID" value="XM_626982.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWD7"/>
    <dbReference type="GeneID" id="3374491"/>
    <dbReference type="KEGG" id="cpv:cgd8_720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_720"/>
    <dbReference type="InParanoid" id="Q5CWD7"/>
    <dbReference type="OrthoDB" id="340201at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="114" mass="12974" checksum="A459E6C0F05D1D47" modified="2005-04-12" version="1">MSFNEHKFKGIKNEWNSEQVIPYIKIQLAEIRSNALKVVEEAFSGIHDSKITNDINIIEAEKRKSDGVAKNIAKEDASILKCSQLDLLKFLKYSNDKLSKYNIGVENISMINSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWE8</accession>
    <name>Q5CWE8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_5380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90106.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627856.1">
        <property type="nucleotide sequence ID" value="XM_627856.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3375851"/>
    <dbReference type="KEGG" id="cpv:cgd6_5380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5380"/>
    <dbReference type="InParanoid" id="Q5CWE8"/>
    <dbReference type="OMA" id="HEREYIG"/>
    <dbReference type="OrthoDB" id="336736at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="709"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1077"/>
            <end position="1104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90106.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1410" mass="164230" checksum="ECA7A29A96FE9A67" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWF7</accession>
    <name>Q5CWF7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_5280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627847.1">
        <property type="nucleotide sequence ID" value="XM_627847.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWF7"/>
    <dbReference type="SMR" id="Q5CWF7"/>
    <dbReference type="GeneID" id="3375842"/>
    <dbReference type="KEGG" id="cpv:cgd6_5280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5280"/>
    <dbReference type="InParanoid" id="Q5CWF7"/>
    <dbReference type="OrthoDB" id="342501at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255031" evidence="2">
        <location>
            <begin position="29"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="223"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="756"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="311"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="396"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="760"/>
            <end position="777"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1114" mass="123698" checksum="1E47AB4CA35609B3" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWK6</accession>
    <name>Q5CWK6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SAC3/GANP/Rpn12p family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_4690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627798.1">
        <property type="nucleotide sequence ID" value="XM_627798.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWK6"/>
    <dbReference type="STRING" id="353152.Q5CWK6"/>
    <dbReference type="GeneID" id="3375801"/>
    <dbReference type="KEGG" id="cpv:cgd6_4690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4690"/>
    <dbReference type="InParanoid" id="Q5CWK6"/>
    <dbReference type="OMA" id="NNARGWI"/>
    <dbReference type="OrthoDB" id="337508at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045107">
        <property type="entry name" value="SAC3/GANP/THP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005062">
        <property type="entry name" value="SAC3/GANP/THP3_conserved"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436">
        <property type="entry name" value="80 KDA MCM3-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12436:SF4">
        <property type="entry name" value="LEUKOCYTE RECEPTOR CLUSTER MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03399">
        <property type="entry name" value="SAC3_GANP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="2">
        <location>
            <begin position="509"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="237"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="691" mass="79173" checksum="52DC0C93731ED8CA" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2010-03-23" modified="2025-02-05" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWQ7</accession>
    <accession>Q7YYM7</accession>
    <name>DRE2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Anamorsin homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Fe-S cluster assembly protein DRE2 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">cgd6_4130</name>
    </gene>
    <organism>
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2003" name="Genome Res." volume="13" first="1787" last="1799">
            <title>Integrated mapping, chromosomal sequencing and sequence analysis of Cryptosporidium parvum.</title>
            <authorList>
                <person name="Bankier A.T."/>
                <person name="Spriggs H.F."/>
                <person name="Fartmann B."/>
                <person name="Konfortov B.A."/>
                <person name="Madera M."/>
                <person name="Vogel C."/>
                <person name="Teichmann S.A."/>
                <person name="Ivens A."/>
                <person name="Dear P.H."/>
            </authorList>
            <dbReference type="PubMed" id="12869580"/>
            <dbReference type="DOI" id="10.1101/gr.1555203"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [GENOMIC DNA]</scope>
        <source>
            <strain>Iowa II</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion intermembrane space</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="1">The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.</text>
    </comment>
    <comment type="domain">
        <text evidence="1">The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the anamorsin family.</text>
    </comment>
    <dbReference type="EMBL" id="BX538352">
        <property type="protein sequence ID" value="CAD98454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627747.1">
        <property type="nucleotide sequence ID" value="XM_627747.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWQ7"/>
    <dbReference type="SMR" id="Q5CWQ7"/>
    <dbReference type="STRING" id="353152.Q5CWQ7"/>
    <dbReference type="EnsemblProtists" id="EAK90016">
        <property type="protein sequence ID" value="EAK90016"/>
        <property type="gene ID" value="cgd6_4130"/>
    </dbReference>
    <dbReference type="GeneID" id="3375761"/>
    <dbReference type="KEGG" id="cpv:cgd6_4130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4130"/>
    <dbReference type="InParanoid" id="Q5CWQ7"/>
    <dbReference type="OrthoDB" id="311633at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000242991">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005758">
        <property type="term" value="C:mitochondrial intermembrane space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009055">
        <property type="term" value="F:electron transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03115">
        <property type="entry name" value="Anamorsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007785">
        <property type="entry name" value="Anamorsin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046408">
        <property type="entry name" value="CIAPIN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13273:SF14">
        <property type="entry name" value="ANAMORSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05093">
        <property type="entry name" value="CIAPIN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0001">2Fe-2S</keyword>
    <keyword id="KW-0004">4Fe-4S</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0408">Iron</keyword>
    <keyword id="KW-0411">Iron-sulfur</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <feature type="chain" id="PRO_0000392352" description="Anamorsin homolog">
        <location>
            <begin position="1"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="N-terminal SAM-like domain" evidence="1">
        <location>
            <begin position="1"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Linker" evidence="1">
        <location>
            <begin position="143"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site A" evidence="1">
        <location>
            <begin position="175"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Fe-S binding site B" evidence="1">
        <location>
            <begin position="218"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 1" evidence="1">
        <location>
            <begin position="218"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Cx2C motif 2" evidence="1">
        <location>
            <begin position="229"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="175"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="229"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="232"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03115"/>
        </source>
    </evidence>
    <sequence length="298" mass="32851" checksum="CD028CD7A6129886" modified="2007-04-03" version="1">MTQLIITHQSDSKLEESEVFLSELNRIKKEEDKFGKFSSLSDLRAIVKKGEFRIVSIYLSSGSILGEIFTFEFLKEFYGVLDFGSVLKVNILALDSIDKVKAFERNLLFSGFIKVKKLKGDGLNSSDSDFEIVIKAEKPSWKPEEGKVLVDDIDLEGSVPDIKNYVPLGQGKESCKSKERACNNCNCGRADLEKEIGVEAARKVYQEKVETGTARSSCGNCYLGDAFRCSGCPYKGMPAFKPGEKVSLANAEGDANDHTVDMNLIHEEKVDLITTTFDDDGSGVNNVQSKGGVLKLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWT8</accession>
    <name>Q5CWT8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627716.1">
        <property type="nucleotide sequence ID" value="XM_627716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWT8"/>
    <dbReference type="GeneID" id="3375903"/>
    <dbReference type="KEGG" id="cpv:cgd6_3770"/>
    <dbReference type="InParanoid" id="Q5CWT8"/>
    <dbReference type="OMA" id="YLNPYYC"/>
    <dbReference type="OrthoDB" id="336754at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="237"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="319"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="370" mass="43652" checksum="EDAC6BF5B85061A2" modified="2005-04-12" version="1" fragment="single">VEKQTFVSSNTLSNYYYHYYSRNKQQQRQNSQRYDALYIVSEKEEDIMKMKGTKDKLKFKEIGNESRKTNKDSISDTSLGYICSLIYNFRNNNTIRSKQSQLTLWEIMKQFYLINNLFFILKVLKTLISSNKTHRLSQDMGWVSFMCLLSTFMTSILAYLTRSFIFYHRIADKYTNKLFSPFHVYCQIRKVGDEMPEALFMLERVNWTYTLIMHILEDIPQLFASSIFLSYYGNDFYAFFMITWSSCMIITTSIRMGISYPLIGTLSLIFSRKPPVDSPTLNEATTTTLHFPLFMAAITFIWAVSDSLCLYFTHGFWTILFYFGLTANILASTLFILYYVHLSKQASAYTRQLNSLYFTEDFSRIQSRHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX33</accession>
    <name>Q5CX33_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="2 5">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_2690</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="2 5"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627621.1">
        <property type="nucleotide sequence ID" value="XM_627621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX33"/>
    <dbReference type="STRING" id="353152.Q5CX33"/>
    <dbReference type="GeneID" id="3376147"/>
    <dbReference type="KEGG" id="cpv:cgd6_2690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2690"/>
    <dbReference type="InParanoid" id="Q5CX33"/>
    <dbReference type="OMA" id="TIAYHID"/>
    <dbReference type="OrthoDB" id="1902587at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001179">
        <property type="entry name" value="PPIase_FKBP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000774">
        <property type="entry name" value="PPIase_FKBP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811:SF19">
        <property type="entry name" value="39 KDA FK506-BINDING NUCLEAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43811">
        <property type="entry name" value="FKBP-TYPE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00254">
        <property type="entry name" value="FKBP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01346">
        <property type="entry name" value="FKBP_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50059">
        <property type="entry name" value="FKBP_PPIASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5 8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0697">Rotamase</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253933" description="peptidylprolyl isomerase" evidence="6">
        <location>
            <begin position="21"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="PPIase FKBP-type" evidence="7">
        <location>
            <begin position="220"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="325" mass="36814" checksum="2BBD80165F40C720" modified="2007-04-03" version="1">MKLFLKVILFLSFVSTISLCSRLEWTGDEFEVKRLTDFIPGTVPQVQRTLMCESCQLITFALKEYISKKLSIYKSSQPPKGFTDIVVSNFLESHVACSNHIWQPLADNSLEFTIEDFISACRSNLSTWEPELELISTSKLSFDQEISRICLGTKSCKDKSELWTEQEYPENRESKKSLLKKRSDEFIAKNKDRKGVITTSSGLQYIVVKEGTGQEKPKPEDEVEVFYRGKTLGGIEFDSSYNRGEEPSKLQISQLIPAWIEALTMMTEGQEVILFAPYDLAYGEQGAGELIGPNEVIIFKLKLGKIIKNENKKPDNEISSASDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX34</accession>
    <name>Q5CX34_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_2680</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627620.1">
        <property type="nucleotide sequence ID" value="XM_627620.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX34"/>
    <dbReference type="GeneID" id="3376145"/>
    <dbReference type="KEGG" id="cpv:cgd6_2680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2680"/>
    <dbReference type="InParanoid" id="Q5CX34"/>
    <dbReference type="OMA" id="VIEIFRI"/>
    <dbReference type="OrthoDB" id="344130at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="915" mass="104719" checksum="D1C6336D93F0A619" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX38</accession>
    <name>Q5CX38_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_2630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627616.1">
        <property type="nucleotide sequence ID" value="XM_627616.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3376143"/>
    <dbReference type="KEGG" id="cpv:cgd6_2630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2630"/>
    <dbReference type="InParanoid" id="Q5CX38"/>
    <dbReference type="OMA" id="FTISNTH"/>
    <dbReference type="OrthoDB" id="336486at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1609" mass="185009" checksum="5F122EC1A3970AED" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXD4</accession>
    <name>Q5CXD4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNA repair protein Rad4p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_1530</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89825.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627520.1">
        <property type="nucleotide sequence ID" value="XM_627520.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXD4"/>
    <dbReference type="STRING" id="353152.Q5CXD4"/>
    <dbReference type="GeneID" id="3376018"/>
    <dbReference type="KEGG" id="cpv:cgd6_1530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1530"/>
    <dbReference type="InParanoid" id="Q5CXD4"/>
    <dbReference type="OMA" id="TAKRANI"/>
    <dbReference type="OrthoDB" id="340039at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000111">
        <property type="term" value="C:nucleotide-excision repair factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071942">
        <property type="term" value="C:XPC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.20.110">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2460">
        <property type="entry name" value="Rad4, beta-hairpin domain BHD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.260.10">
        <property type="entry name" value="Transglutaminase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018327">
        <property type="entry name" value="BHD_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004583">
        <property type="entry name" value="DNA_repair_Rad4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018325">
        <property type="entry name" value="Rad4/PNGase_transGLS-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018326">
        <property type="entry name" value="Rad4_beta-hairpin_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018328">
        <property type="entry name" value="Rad4_beta-hairpin_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042488">
        <property type="entry name" value="Rad4_BHD3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036985">
        <property type="entry name" value="Transglutaminase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-C CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12135">
        <property type="entry name" value="DNA REPAIR PROTEIN XP-C / RAD4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10403">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10405">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03835">
        <property type="entry name" value="Rad4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01030">
        <property type="entry name" value="BHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01031">
        <property type="entry name" value="BHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01032">
        <property type="entry name" value="BHD_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="6">
        <location>
            <begin position="436"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="7">
        <location>
            <begin position="489"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Rad4 beta-hairpin" evidence="8">
        <location>
            <begin position="550"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89825.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="735" mass="86154" checksum="587C17FE4DE765EB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXD5</accession>
    <name>Q5CXD5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Threonylcarbamoyladenosine tRNA methylthiotransferase</fullName>
            <ecNumber evidence="4">2.8.4.5</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">tRNA-t(6)A37 methylthiotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd6_1520</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-SH + AH2 + 2 S-adenosyl-L-methionine = 2-methylsulfanyl-N(6)-L-threonylcarbamoyladenosine(37) in tRNA + (sulfur carrier)-H + 5'-deoxyadenosine + L-methionine + A + S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:37075"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="Rhea" id="RHEA-COMP:11092"/>
            <dbReference type="Rhea" id="RHEA-COMP:14737"/>
            <dbReference type="Rhea" id="RHEA-COMP:14739"/>
            <dbReference type="ChEBI" id="CHEBI:13193"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:17499"/>
            <dbReference type="ChEBI" id="CHEBI:29917"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:64428"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:74420"/>
            <dbReference type="EC" id="2.8.4.5"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the methylthiotransferase family. CDKAL1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.4.5" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627519.1">
        <property type="nucleotide sequence ID" value="XM_627519.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXD5"/>
    <dbReference type="FunCoup" id="Q5CXD5">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXD5"/>
    <dbReference type="GeneID" id="3376017"/>
    <dbReference type="KEGG" id="cpv:cgd6_1520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1520"/>
    <dbReference type="InParanoid" id="Q5CXD5"/>
    <dbReference type="OMA" id="HYAYPTG"/>
    <dbReference type="OrthoDB" id="1730074at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035598">
        <property type="term" value="F:tRNA (N(6)-L-threonylcarbamoyladenosine(37)-C(2))-methylthiotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.80.30.20:FF:000002">
        <property type="entry name" value="threonylcarbamoyladenosine tRNA methylthiotransferase isoform X2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12160">
        <property type="entry name" value="Methylthiotransferase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.30.20">
        <property type="entry name" value="tm_1862 like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005839">
        <property type="entry name" value="Methylthiotransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020612">
        <property type="entry name" value="Methylthiotransferase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013848">
        <property type="entry name" value="Methylthiotransferase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038135">
        <property type="entry name" value="Methylthiotransferase_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006466">
        <property type="entry name" value="MiaB-like_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023404">
        <property type="entry name" value="rSAM_horseshoe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01578">
        <property type="entry name" value="MiaB-like-B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00089">
        <property type="entry name" value="MiaB/RimO family radical SAM methylthiotransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918">
        <property type="entry name" value="RADICAL SAM PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11918:SF45">
        <property type="entry name" value="THREONYLCARBAMOYLADENOSINE TRNA METHYLTHIOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00919">
        <property type="entry name" value="UPF0004"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01082">
        <property type="entry name" value="B12-binding_domain_containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51449">
        <property type="entry name" value="MTTASE_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01278">
        <property type="entry name" value="MTTASE_RADICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="15" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="15" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0819">tRNA processing</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="MTTase N-terminal" evidence="16">
        <location>
            <begin position="102"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="17">
        <location>
            <begin position="245"/>
            <end position="475"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00018810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00031213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00051661"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAK89824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="543" mass="61246" checksum="CDC45BC99D2B1B88" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXP3</accession>
    <name>Q5CXP3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Very large low complexity protein, probably membrane associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_5440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628687.1">
        <property type="nucleotide sequence ID" value="XM_628685.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXP3"/>
    <dbReference type="GeneID" id="3372151"/>
    <dbReference type="KEGG" id="cpv:cgd7_5440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5440"/>
    <dbReference type="InParanoid" id="Q5CXP3"/>
    <dbReference type="OMA" id="IRISSWQ"/>
    <dbReference type="OrthoDB" id="343704at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1992"/>
            <end position="2012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1994"/>
            <end position="2012"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="3229" mass="363419" checksum="42FF51B3AF9762F6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXQ4</accession>
    <name>Q5CXQ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin/PDI, cyanobacterial type, signal peptide plus 4 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_5330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628676.1">
        <property type="nucleotide sequence ID" value="XM_628674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXQ4"/>
    <dbReference type="GeneID" id="3372142"/>
    <dbReference type="KEGG" id="cpv:cgd7_5330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5330"/>
    <dbReference type="InParanoid" id="Q5CXQ4"/>
    <dbReference type="OMA" id="AINEMIW"/>
    <dbReference type="OrthoDB" id="343052at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="126"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="186"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="405"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="633"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="436"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="544"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="636"/>
            <end position="649"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="664" mass="75575" checksum="7B18A94C2685AC33" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXT8</accession>
    <name>Q5CXT8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large uncharacterized low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628642.1">
        <property type="nucleotide sequence ID" value="XM_628640.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372234"/>
    <dbReference type="KEGG" id="cpv:cgd7_4980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4980"/>
    <dbReference type="InParanoid" id="Q5CXT8"/>
    <dbReference type="OMA" id="GSHIMIN"/>
    <dbReference type="OrthoDB" id="341860at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="561"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="817"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2031"/>
            <end position="2057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2072"/>
            <end position="2098"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="173"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="565"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2038"/>
            <end position="2056"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2076"/>
            <end position="2098"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2151" mass="246628" checksum="055F1D6E01CFE0C9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXW0</accession>
    <name>Q5CXW0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628620.1">
        <property type="nucleotide sequence ID" value="XM_628618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXW0"/>
    <dbReference type="GeneID" id="3372196"/>
    <dbReference type="KEGG" id="cpv:cgd7_4720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4720"/>
    <dbReference type="InParanoid" id="Q5CXW0"/>
    <dbReference type="OMA" id="GTHRSYT"/>
    <dbReference type="OrthoDB" id="337815at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="210"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="224"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="239" mass="26151" checksum="C7F0E44FDEC31AA1" modified="2005-04-12" version="1">MEEPRVTYSEDRRRQSELLAEAQNQAMEGELSRGFFVSTEVENNQSSVCGIGCGSNGQRLTHTIRAFTKPIPVAPGQVKLNSADELIGKPIIKQRLNEMYTNRNLNTSTTNKFMSFGVASLRSMNSNALSSYRSTGSGSMPTNRSYTYLSQVNTNNFSTMNTGISQYSRGVTSNTSSVFNTFTTILNGLCSCPGFISVCNNKKKIHAIEQEQIPSDSDFAESGSESDDAGLDVAQEEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXW4</accession>
    <name>Q5CXW4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628616.1">
        <property type="nucleotide sequence ID" value="XM_628614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXW4"/>
    <dbReference type="GeneID" id="3372191"/>
    <dbReference type="KEGG" id="cpv:cgd7_4680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4680"/>
    <dbReference type="InParanoid" id="Q5CXW4"/>
    <dbReference type="OMA" id="RWILICI"/>
    <dbReference type="OrthoDB" id="341970at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255073" evidence="2">
        <location>
            <begin position="24"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="139"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="388" mass="44830" checksum="64A3D81BBBE74CE2" modified="2005-04-12" version="1">MMKVLVGLGCLLLIVTHILCANAIHLGSPNYRTVYVSRKKIPTRPLPERFRGELYSDGSIGWLCSRRINGRWTGWIPVSESRVPPQMVKQMRSQLSRKPRKVPQMYRERIMSPSFEELDQEMFSEDSFELVQPSITQQQGKQFTWDEESQSDEASPLQLQEMPSISTKSHREYNTRAGGYPALQQTRIERKTIPSRIQKVYQTSTTVPGDSDEADIARYFEEQNTPPIAGRKGIKGIFRDTFKTTVPELELASPTFSQNSPIQAIPPKGYLPIQPQHPSDYDLNRMQWRFFLTSYSPELDNVRIIKRIPPLGMKLSKTVTECTNNYHKAFKLHYLTVSGMMFSNKINRVVSNSINRELKQWCSGMMTNWYRQLQKMGLVVPKPSKFIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY12</accession>
    <name>Q5CY12_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UDP-N-acetylgalactosamine: polypeptide N-acetylgalactosaminyltransferase, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_4120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628568.1">
        <property type="nucleotide sequence ID" value="XM_628566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY12"/>
    <dbReference type="STRING" id="353152.Q5CY12"/>
    <dbReference type="GeneID" id="3372071"/>
    <dbReference type="KEGG" id="cpv:cgd7_4120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4120"/>
    <dbReference type="InParanoid" id="Q5CY12"/>
    <dbReference type="OMA" id="RANCKPF"/>
    <dbReference type="OrthoDB" id="6119243at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005112">
        <property type="term" value="F:Notch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008593">
        <property type="term" value="P:regulation of Notch signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF63">
        <property type="entry name" value="POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254532" evidence="2">
        <location>
            <begin position="22"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="3">
        <location>
            <begin position="61"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="414" mass="47631" checksum="A252F3EE61D0A5D4" modified="2005-04-12" version="1">MRNAFPLGLAICYLMLKVALTTFVFGSKEEFTTLPRELINSWLEENEYAGLYGKSDIFSIVIIPDCEDNELIDVTINSILLTANRNLLHEIIIISNDCRDSGKDIKSHLGEKFLDKPLIKIIETELQELGELQNLGANNSTGEIILFVPSATLFPKNWMSPIMRSLSDNYKSIIVPRFKKLNKDKWTFSNNDPVYSPKMMFTKEFELTNIHTLDNKVPMFYSKIFAITKSWWLNISKLSDPTINLIFKTSINFDISLRSWNCGGRVAQIAELSFGVTKVKIPQPSLEIRQVLLESWIDEPTKQMIMNNSEKLANYMKLSSGLFEVLINKRKELIKEYECDQKLIFTSKFYNELSEFGLIEYPRSQIVFSGNGKCFTLIGNEKKSGEKNFELKLSECKPNENAQIFYIDNESKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY48</accession>
    <name>Q5CY48_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Crooked neck protein HAT repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_3690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the crooked-neck family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90363.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628532.1">
        <property type="nucleotide sequence ID" value="XM_628530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY48"/>
    <dbReference type="FunCoup" id="Q5CY48">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY48"/>
    <dbReference type="GeneID" id="3372118"/>
    <dbReference type="KEGG" id="cpv:cgd7_3690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3690"/>
    <dbReference type="InParanoid" id="Q5CY48"/>
    <dbReference type="OMA" id="HIKVWIS"/>
    <dbReference type="OrthoDB" id="541719at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071014">
        <property type="term" value="C:post-mRNA release spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003107">
        <property type="entry name" value="HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059164">
        <property type="entry name" value="HAT_PRP39_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045075">
        <property type="entry name" value="Syf1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246:SF3">
        <property type="entry name" value="CROOKED NECK-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11246">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23241">
        <property type="entry name" value="HAT_PRP39_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23240">
        <property type="entry name" value="HAT_PRP39_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00386">
        <property type="entry name" value="HAT"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90363.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="736" mass="87915" checksum="7CBE01D787C1D002" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY75</accession>
    <name>Q5CY75_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">SNF5 like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90341.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628505.1">
        <property type="nucleotide sequence ID" value="XM_628503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY75"/>
    <dbReference type="GeneID" id="3372056"/>
    <dbReference type="KEGG" id="cpv:cgd7_3410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3410"/>
    <dbReference type="InParanoid" id="Q5CY75"/>
    <dbReference type="OMA" id="RQTHICA"/>
    <dbReference type="OrthoDB" id="338486at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90341.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="592" mass="68504" checksum="51D4D8567F9AF0CF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY76</accession>
    <name>Q5CY76_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628504.1">
        <property type="nucleotide sequence ID" value="XM_628502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY76"/>
    <dbReference type="GeneID" id="3372055"/>
    <dbReference type="KEGG" id="cpv:cgd7_3400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3400"/>
    <dbReference type="InParanoid" id="Q5CY76"/>
    <dbReference type="OrthoDB" id="341533at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254370" evidence="1">
        <location>
            <begin position="23"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="145" mass="16366" checksum="E469C1801CA4EDBE" modified="2005-04-12" version="1">MMEFKYIVVCVILYLIHDTIEANSIHNKIQLGSFAEYDILDIIANTKRSGTNLRRNLSSLEINKQFNSSIVPAYMKINHGACKEQYREQTIHISSSPVFISLNYSIDNQIEVNGTDSISIKCCSTIISPKLITNVNTTHVVDLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYA1</accession>
    <name>Q5CYA1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">LisH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628479.1">
        <property type="nucleotide sequence ID" value="XM_628477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYA1"/>
    <dbReference type="GeneID" id="3372294"/>
    <dbReference type="KEGG" id="cpv:cgd7_3140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3140"/>
    <dbReference type="InParanoid" id="Q5CYA1"/>
    <dbReference type="OMA" id="ILVMIRE"/>
    <dbReference type="OrthoDB" id="337720at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="187" mass="22042" checksum="E494FE7674F8389A" modified="2005-04-12" version="1">MNELDQEYVQEKIHEFLDDERLIKSIKSYLRIHITKALRKKSNIKFNLLQDEKLVILFKLIHEFLNFYEINNTCRMLEEECADIFQVNIEAFDDRLGELGALNGGSECNTKIETLLENKLFCREKCEIDEVTNTVLIEASNCIESLQDEIKTLHNAYFEQVNTAREIMEKKVSNIEKLYLESLLRND</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYE4</accession>
    <name>Q5CYE4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">S-adenosylmethionine synthase</fullName>
            <ecNumber evidence="10">2.5.1.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd7_2650</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2019" name="Acta Crystallogr. F Struct. Biol. Commun." volume="75" first="290" last="298">
            <title>Structure of a critical metabolic enzyme: S-adenosylmethionine synthetase from Cryptosporidium parvum.</title>
            <authorList>
                <person name="Ohren J."/>
                <person name="Parungao G.G."/>
                <person name="Viola R.E."/>
            </authorList>
            <dbReference type="PubMed" id="30950830"/>
            <dbReference type="DOI" id="10.1107/s2053230x19002772"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) IN COMPLEX WITH MG(2+)</scope>
    </reference>
    <comment type="function">
        <text evidence="10">Catalyzes the formation of S-adenosylmethionine from methionine and ATP.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-methionine + ATP + H2O = S-adenosyl-L-methionine + phosphate + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21080"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="EC" id="2.5.1.6"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
        <text evidence="10">Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="10">Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the AdoMet synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.6" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90283.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628436.1">
        <property type="nucleotide sequence ID" value="XM_628434.1"/>
    </dbReference>
    <dbReference type="PDB" id="6C07">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.85 A"/>
        <property type="chains" value="A/B/C/D=1-406"/>
    </dbReference>
    <dbReference type="PDBsum" id="6C07"/>
    <dbReference type="AlphaFoldDB" id="Q5CYE4"/>
    <dbReference type="SMR" id="Q5CYE4"/>
    <dbReference type="FunCoup" id="Q5CYE4">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYE4"/>
    <dbReference type="GeneID" id="3371931"/>
    <dbReference type="KEGG" id="cpv:cgd7_2650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2650"/>
    <dbReference type="InParanoid" id="Q5CYE4"/>
    <dbReference type="OMA" id="ASYMARY"/>
    <dbReference type="OrthoDB" id="5852090at2759"/>
    <dbReference type="BRENDA" id="2.5.1.6">
        <property type="organism ID" value="1728"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00315">
        <property type="reaction ID" value="UER00080"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004478">
        <property type="term" value="F:methionine adenosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006730">
        <property type="term" value="P:one-carbon metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006556">
        <property type="term" value="P:S-adenosylmethionine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18079">
        <property type="entry name" value="S-AdoMet_synt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.10:FF:000003">
        <property type="entry name" value="S-adenosylmethionine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.10">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022631">
        <property type="entry name" value="ADOMET_SYNTHASE_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022630">
        <property type="entry name" value="S-AdoMet_synt_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022629">
        <property type="entry name" value="S-AdoMet_synt_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022628">
        <property type="entry name" value="S-AdoMet_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002133">
        <property type="entry name" value="S-AdoMet_synthetase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022636">
        <property type="entry name" value="S-AdoMet_synthetase_sfam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01034">
        <property type="entry name" value="metK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11964">
        <property type="entry name" value="S-ADENOSYLMETHIONINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02773">
        <property type="entry name" value="S-AdoMet_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02772">
        <property type="entry name" value="S-AdoMet_synt_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00438">
        <property type="entry name" value="S-AdoMet_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000497">
        <property type="entry name" value="MAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55973">
        <property type="entry name" value="S-adenosylmethionine synthetase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00376">
        <property type="entry name" value="ADOMET_SYNTHASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00377">
        <property type="entry name" value="ADOMET_SYNTHASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10 17" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0554">One-carbon metabolism</keyword>
    <keyword evidence="9 10" id="KW-0630">Potassium</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="S-adenosylmethionine synthetase N-terminal" evidence="12">
        <location>
            <begin position="23"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase central" evidence="13">
        <location>
            <begin position="134"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="S-adenosylmethionine synthetase C-terminal" evidence="14">
        <location>
            <begin position="260"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="62"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="182"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>4</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>3</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009685"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF02772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK90283.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="6C07"/>
        </source>
    </evidence>
    <sequence length="406" mass="44841" checksum="DCE63CD2D4AEAC27" modified="2007-04-03" version="1">MDSSRFSGNKSTYTDLQTTSEQFLFSSESVCSGHPDKLCDQISDAILDACLEQDPESFVACETCTKTGFIMVFGEITTKANVNYERVVRETVKEIGYDSEEKGLDYKTMDVIIKLEQQSNQIAGCVHVDKNVEDIGAGDQGMMFGYATNETKELMPLTHVLATSITRELDYIRVKGVSSRVGWLRPDGKAQVTVEYNCKHGVLIPKRIHTILVSVQHDENIENEEIREFVLENVIKKVCPSDLMDKETRILINPSGRFTIGGPAADAGLTGRKIIVDTYGGWGAHGGGAFSGKDATKVDRSGAYMARLVAKSIVFSGLCSRCLVQVSYGIGIARPLSLYINTFGTAKDGYNDAKLLEIVNKVFDFRPGILIKQLNLKSPIFKKTSSGGHFGRSEEEFLWEKPIILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYE7</accession>
    <name>Q5CYE7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ClpB ATpase (Bacterial), signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_2620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628433.1">
        <property type="nucleotide sequence ID" value="XM_628431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYE7"/>
    <dbReference type="FunCoup" id="Q5CYE7">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYE7"/>
    <dbReference type="GeneID" id="3371928"/>
    <dbReference type="KEGG" id="cpv:cgd7_2620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2620"/>
    <dbReference type="InParanoid" id="Q5CYE7"/>
    <dbReference type="OMA" id="DASHIAY"/>
    <dbReference type="OrthoDB" id="47330at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034605">
        <property type="term" value="P:cellular response to heat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041546">
        <property type="entry name" value="ClpA/ClpB_AAA_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050130">
        <property type="entry name" value="ClpA_ClpB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638">
        <property type="entry name" value="ATP-DEPENDENT CLP PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11638:SF18">
        <property type="entry name" value="HEAT SHOCK PROTEIN 104"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07724">
        <property type="entry name" value="AAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17871">
        <property type="entry name" value="AAA_lid_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254379" evidence="3">
        <location>
            <begin position="32"/>
            <end position="1263"/>
        </location>
    </feature>
    <feature type="domain" description="ClpA/ClpB AAA lid" evidence="5">
        <location>
            <begin position="651"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase AAA-type core" evidence="4">
        <location>
            <begin position="983"/>
            <end position="1141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF07724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1263" mass="145141" checksum="9BC0970D8C6A95F2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYG1</accession>
    <name>Q5CYG1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">TBC domain protein (Small GTpase GAP), 3 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_2460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628419.1">
        <property type="nucleotide sequence ID" value="XM_628417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYG1"/>
    <dbReference type="STRING" id="353152.Q5CYG1"/>
    <dbReference type="GeneID" id="3372216"/>
    <dbReference type="KEGG" id="cpv:cgd7_2460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2460"/>
    <dbReference type="InParanoid" id="Q5CYG1"/>
    <dbReference type="OMA" id="GRINICF"/>
    <dbReference type="OrthoDB" id="206700at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045913">
        <property type="entry name" value="TBC20/Gyp8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913:SF7">
        <property type="entry name" value="RE60063P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20913">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 20/GTPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="204"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="228"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="347"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="3">
        <location>
            <begin position="1"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="379" mass="44728" checksum="4EE908DF781F959A" modified="2005-04-12" version="1">MNDSRRFVWCILLKISIEDINRKISISSLVQNADKTLINQVNCDVDRCDLQSDIDKLNLKRLLISVFSYRRENYSYIQGIHEIGKVFLTLFHEYKKSNLANIKKKLSKLIVFSERFEAIILCKLLIKKFNSEKGRADICFKAFDRFLMLYSTPYIYKSDSLAQINLEYILSNISRDLLYLLNKRSPILYNFFVKLKAKDDKESSVCIFILPWIITYFSHNISVKQKKLTYYIFDHIISSHPLYIVFLIVEIIIQSETKLFDYLEQNFGLDISLNFEENEIYPFVHFFFQNLDISNLNWKVIVSCSHKYLSSTRLNILNSYFLWEAGKGSKHDLRIGTTLFSKMNVKVLIYSIFLVLISSLLFSIYVGEFNFLKIIKKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYI2</accession>
    <name>Q5CYI2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_2240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628398.1">
        <property type="nucleotide sequence ID" value="XM_628396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYI2"/>
    <dbReference type="GeneID" id="3372203"/>
    <dbReference type="KEGG" id="cpv:cgd7_2240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2240"/>
    <dbReference type="InParanoid" id="Q5CYI2"/>
    <dbReference type="OMA" id="TSRMIEN"/>
    <dbReference type="OrthoDB" id="338188at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254550" evidence="2">
        <location>
            <begin position="26"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="86"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="544" mass="62063" checksum="CA8F17846497893B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYL3</accession>
    <name>Q5CYL3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NADH:ubiquinone reductase (non-electrogenic)</fullName>
            <ecNumber evidence="2">1.6.5.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_1900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a quinone + NADH + H(+) = a quinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:46160"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:24646"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:132124"/>
            <dbReference type="EC" id="1.6.5.9"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ubiquinone + NADH + H(+) = a ubiquinol + NAD(+)</text>
            <dbReference type="Rhea" id="RHEA:23152"/>
            <dbReference type="Rhea" id="RHEA-COMP:9565"/>
            <dbReference type="Rhea" id="RHEA-COMP:9566"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16389"/>
            <dbReference type="ChEBI" id="CHEBI:17976"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the NADH dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.5.9" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628367.1">
        <property type="nucleotide sequence ID" value="XM_628365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYL3"/>
    <dbReference type="FunCoup" id="Q5CYL3">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYL3"/>
    <dbReference type="GeneID" id="3371749"/>
    <dbReference type="KEGG" id="cpv:cgd7_1900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1900"/>
    <dbReference type="InParanoid" id="Q5CYL3"/>
    <dbReference type="OMA" id="QIPAQKD"/>
    <dbReference type="OrthoDB" id="3244603at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050136">
        <property type="term" value="F:NADH dehydrogenase (quinone) (non-electrogenic) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023753">
        <property type="entry name" value="FAD/NAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045024">
        <property type="entry name" value="NDH-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706:SF47">
        <property type="entry name" value="EXTERNAL NADH-UBIQUINONE OXIDOREDUCTASE 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43706">
        <property type="entry name" value="NADH DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07992">
        <property type="entry name" value="Pyr_redox_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="6" id="KW-0520">NAD</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD/NAD(P)-binding" evidence="9">
        <location>
            <begin position="64"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047599"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF07992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="568" mass="64181" checksum="0E04C22EC2FA41B4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYR1</accession>
    <name>Q5CYR1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_1350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628319.1">
        <property type="nucleotide sequence ID" value="XM_628317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYR1"/>
    <dbReference type="GeneID" id="3372237"/>
    <dbReference type="KEGG" id="cpv:cgd7_1350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1350"/>
    <dbReference type="InParanoid" id="Q5CYR1"/>
    <dbReference type="OMA" id="QWLENIK"/>
    <dbReference type="OrthoDB" id="342822at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="75"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="402" mass="44472" checksum="E799EFAAB349E306" modified="2005-04-12" version="1">MQPIGAFGMVPQLINPPVMMVPGRSSGKGSSGNCCGGSNSKRKGSCGSCGRCFGSLFIILFAFICTSCCYAYPIYNSFTNPEYFKKQETPIWTWETAFSKAKEIGYSMSLTKSPEDGNGTSENTARSREMDRVQFLKLNSTDDNNRNASTFINLENILGQNSSKIFFPPYNNTYISSLLYSNPERKLSIRGGVGGLNLVKDLAIGVKTKQIPNKYFNKEYCDRGREEKSEGVWNEFCNYKHNVTNLECIDMMNGPAICVGIRNRKYEVFSVSKQCKFIDPEIPVEIFPTISDICYSGKYLNSSLATFNITKPICPCMISSSPVDNLELNENTTIATTLTGNQKTRDFILQDKANPETQKMLRGPEGISDSSSNSGLIHSTAKTLNHAIPGNNTNSTLKMLNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYR6</accession>
    <name>Q5CYR6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_1290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90186.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628314.1">
        <property type="nucleotide sequence ID" value="XM_628312.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYR6"/>
    <dbReference type="GeneID" id="3372257"/>
    <dbReference type="KEGG" id="cpv:cgd7_1290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1290"/>
    <dbReference type="InParanoid" id="Q5CYR6"/>
    <dbReference type="OMA" id="KPADTIK"/>
    <dbReference type="OrthoDB" id="344267at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253992" evidence="2">
        <location>
            <begin position="25"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="371"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="392"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="447"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="534"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90186.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="579" mass="66113" checksum="A75B2F5841DBB148" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYT9</accession>
    <name>Q5CYT9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Imp3p-like 40S ribosomal protein S9. S4 RNA binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_1040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628291.1">
        <property type="nucleotide sequence ID" value="XM_628289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYT9"/>
    <dbReference type="FunCoup" id="Q5CYT9">
        <property type="interactions" value="125"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYT9"/>
    <dbReference type="GeneID" id="3371776"/>
    <dbReference type="KEGG" id="cpv:cgd7_1040"/>
    <dbReference type="InParanoid" id="Q5CYT9"/>
    <dbReference type="OMA" id="FRIKHEQ"/>
    <dbReference type="OrthoDB" id="10248812at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001912">
        <property type="entry name" value="Ribosomal_uS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00163">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01390">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="10" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS4 N-terminal" evidence="9">
        <location>
            <begin position="8"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="112"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM01390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="188" mass="22280" checksum="47E6B3D97E2F8670" modified="2005-04-12" version="1" fragment="single">VGEVLMRKLKFHEQKLLKKVNLYSWKKEDNERETKILRRYYIQDREDYTKYNKLCGLITKLVSGIRKLPPEDEFRKTTSEMLLKKLYHMGVIPTYKSLEAINELSASAFCRRRLAVVLVQLKFCPNLKDSVKFIEQGHIRIGPNTITNPAYHISREMEDHITWTQGSKIKSIMQKFNNEYDDFDFLGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYY1</accession>
    <name>Q5CYY1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser/Thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628249.1">
        <property type="nucleotide sequence ID" value="XM_628247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYY1"/>
    <dbReference type="STRING" id="353152.Q5CYY1"/>
    <dbReference type="GeneID" id="3372004"/>
    <dbReference type="KEGG" id="cpv:cgd7_590"/>
    <dbReference type="InParanoid" id="Q5CYY1"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="1"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="228" mass="26661" checksum="09E6C151BCF97ABC" modified="2005-04-12" version="1">MRGQWRYILLYCGGDFQESGLAPLIATTGTKYSHPKYKIRHALALITPYCEYGNGISLIKNLSGQRHIYYYTCDLLHYNLLLIIKALSFLESYEIFHGNIKLSNIYVNATGFILLLGDFMLPLRIKHWFIEIMKKNANIPLNVSPELRYALTKPNYKTYEDFEKEVDLHKNDVFCLAMVFLSLSLIYEPKEKDYKRLRSFVKESLLKLAADPAWSAGKFLKYQQWFLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYZ3</accession>
    <name>Q5CYZ3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">L-lactate dehydrogenase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd7_470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2007" name="Mol. Biochem. Parasitol." volume="151" first="100" last="110">
            <title>Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.</title>
            <authorList>
                <person name="Vedadi M."/>
                <person name="Lew J."/>
                <person name="Artz J."/>
                <person name="Amani M."/>
                <person name="Zhao Y."/>
                <person name="Dong A."/>
                <person name="Wasney G.A."/>
                <person name="Gao M."/>
                <person name="Hills T."/>
                <person name="Brokx S."/>
                <person name="Qiu W."/>
                <person name="Sharma S."/>
                <person name="Diassiti A."/>
                <person name="Alam Z."/>
                <person name="Melone M."/>
                <person name="Mulichak A."/>
                <person name="Wernimont A."/>
                <person name="Bray J."/>
                <person name="Loppnau P."/>
                <person name="Plotnikova O."/>
                <person name="Newberry K."/>
                <person name="Sundararajan E."/>
                <person name="Houston S."/>
                <person name="Walker J."/>
                <person name="Tempel W."/>
                <person name="Bochkarev A."/>
                <person name="Kozieradzki I."/>
                <person name="Edwards A."/>
                <person name="Arrowsmith C."/>
                <person name="Roos D."/>
                <person name="Kain K."/>
                <person name="Hui R."/>
            </authorList>
            <dbReference type="PubMed" id="17125854"/>
            <dbReference type="DOI" id="10.1016/j.molbiopara.2006.10.011"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.20 ANGSTROMS)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>(S)-lactate + NAD(+) = pyruvate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:23444"/>
            <dbReference type="ChEBI" id="CHEBI:15361"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16651"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="EC" id="1.1.1.27"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the LDH/MDH superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628237.1">
        <property type="nucleotide sequence ID" value="XM_628235.1"/>
    </dbReference>
    <dbReference type="PDB" id="2HJR">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.20 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H/I/J/K/L=1-328"/>
    </dbReference>
    <dbReference type="PDBsum" id="2HJR"/>
    <dbReference type="AlphaFoldDB" id="Q5CYZ3"/>
    <dbReference type="SMR" id="Q5CYZ3"/>
    <dbReference type="FunCoup" id="Q5CYZ3">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYZ3"/>
    <dbReference type="GeneID" id="3371767"/>
    <dbReference type="KEGG" id="cpv:cgd7_470"/>
    <dbReference type="InParanoid" id="Q5CYZ3"/>
    <dbReference type="OMA" id="EIMINAQ"/>
    <dbReference type="OrthoDB" id="4069699at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CYZ3"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004459">
        <property type="term" value="F:L-lactate dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006089">
        <property type="term" value="P:lactate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01339">
        <property type="entry name" value="LDH-like_MDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000018">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.110.10:FF:000004">
        <property type="entry name" value="Malate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.110.10">
        <property type="entry name" value="Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00487">
        <property type="entry name" value="Malate_dehydrog_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001557">
        <property type="entry name" value="L-lactate/malate_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022383">
        <property type="entry name" value="Lactate/malate_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001236">
        <property type="entry name" value="Lactate/malate_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015955">
        <property type="entry name" value="Lactate_DH/Glyco_Ohase_4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011275">
        <property type="entry name" value="Malate_DH_type3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01763">
        <property type="entry name" value="MalateDH_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004863">
        <property type="entry name" value="PRK06223.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128">
        <property type="entry name" value="L-2-HYDROXYCARBOXYLATE DEHYDROGENASE (NAD(P)(+))"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43128:SF16">
        <property type="entry name" value="L-LACTATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02866">
        <property type="entry name" value="Ldh_1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00056">
        <property type="entry name" value="Ldh_1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000102">
        <property type="entry name" value="Lac_mal_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00086">
        <property type="entry name" value="LLDHDRGNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56327">
        <property type="entry name" value="LDH C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 7" id="KW-0520">NAD</keyword>
    <keyword evidence="2 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Lactate/malate dehydrogenase N-terminal" evidence="9">
        <location>
            <begin position="16"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Lactate/malate dehydrogenase C-terminal" evidence="10">
        <location>
            <begin position="159"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="187"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="21"/>
            <end position="26"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="45"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="94"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="100"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="130"/>
            <end position="132"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="132"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00016495"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00049258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000102-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02866"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK90670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="2HJR"/>
        </source>
    </evidence>
    <sequence length="328" mass="35080" checksum="AD845C7533C9900F" modified="2005-04-12" version="1" fragment="single">LKKISYKYNTVIMRKKISIIGAGQIGSTIALLLGQKDLGDVYMFDIIEGVPQGKALDLNHCMALIGSPAKIFGENNYEYLQNSDVVIITAGVPRKPNMTRSDLLTVNAKIVGSVAENVGKYCPNAFVICITNPLDAMVYYFKEKSGIPANKVCGMSGVLDSARFRCNLSRALGVKPSDVSAIVVGGHGDEMIPLTSSVTIGGILLSDFVEQGKITHSQINEIIKKTAFGGGEIVELLKTGSAFYAPAASAVAMAQAYLKDSKSVLVCSTYLTGQYNVNNLFVGVPVVIGKNGIEDVVIVNLSDDEKSLFSKSVESIQNLVQDLKSLNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPL6</accession>
    <name>A3FPL6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">cAMP-dependent protein kinase regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd7_120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cAMP-dependent kinase regulatory chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388362.1">
        <property type="nucleotide sequence ID" value="XM_001388325.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPL6"/>
    <dbReference type="FunCoup" id="A3FPL6">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPL6"/>
    <dbReference type="GeneID" id="3371821"/>
    <dbReference type="KEGG" id="cpv:cgd7_120"/>
    <dbReference type="InParanoid" id="A3FPL6"/>
    <dbReference type="OMA" id="WSPPHHP"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030552">
        <property type="term" value="F:cAMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004862">
        <property type="term" value="F:cAMP-dependent protein kinase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034236">
        <property type="term" value="F:protein kinase A catalytic subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00038">
        <property type="entry name" value="CAP_ED"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000039">
        <property type="entry name" value="cAMP-dependent protein kinase regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.10:FF:000006">
        <property type="entry name" value="cAMP-dependent protein kinase type I-alpha regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050503">
        <property type="entry name" value="cAMP-dep_PK_reg_su-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012198">
        <property type="entry name" value="cAMP_dep_PK_reg_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018488">
        <property type="entry name" value="cNMP-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000595">
        <property type="entry name" value="cNMP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018490">
        <property type="entry name" value="cNMP-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE REGULATORY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11635:SF152">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE TYPE I REGULATORY SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00027">
        <property type="entry name" value="cNMP_binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000548">
        <property type="entry name" value="PK_regulatory"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00103">
        <property type="entry name" value="CAMPKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00100">
        <property type="entry name" value="cNMP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51206">
        <property type="entry name" value="cAMP-binding domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00888">
        <property type="entry name" value="CNMP_BINDING_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00889">
        <property type="entry name" value="CNMP_BINDING_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50042">
        <property type="entry name" value="CNMP_BINDING_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0114">cAMP</keyword>
    <keyword evidence="4 8" id="KW-0116">cAMP-binding</keyword>
    <keyword evidence="6 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="99"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclic nucleotide-binding" evidence="10">
        <location>
            <begin position="222"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="178"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="287"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="296"/>
        </location>
        <ligand>
            <name>3',5'-cyclic AMP</name>
            <dbReference type="ChEBI" id="CHEBI:58165"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000548-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="345" mass="38794" checksum="55FF720997D50F54" modified="2007-04-03" version="1" fragment="single">NFYSASSVDAVHPKKSSGKEDKRKKTSGTSSGSESESDSDDVRDNIEIPKNFLARGPRTSVSAEAYGAWNKMKDFTPPSYPKTKEQEKRIREKLLESFMFTSLDDDELKTVILACVETSVKKDTEIITQGDNGDKLYIIDQGVVECYKKTSTEPRKHLCDLNPGDAFGELALLYNCPRAASVVAKTDCLLWALDRETFNHIVKGSASKRISTYETFLKEVEILKTMDVYELNKLTMVLKSSIFEDGQEIIKQGEQGDTFYLIITGNAVALKDNVEVMSYKRGDYFGELALLRNAPRAATVKARGRCKVAYLDRKAFKRVLGPIEDILKRNTDKYKTVIKKITTKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPQ8</accession>
    <name>A3FPQ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Sec61-gamma subunit of protein translocation complex, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd7_4210</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SecE/SEC61-gamma family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388404.1">
        <property type="nucleotide sequence ID" value="XM_001388367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPQ8"/>
    <dbReference type="FunCoup" id="A3FPQ8">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPQ8"/>
    <dbReference type="GeneID" id="3371806"/>
    <dbReference type="KEGG" id="cpv:cgd7_4210"/>
    <dbReference type="InParanoid" id="A3FPQ8"/>
    <dbReference type="OMA" id="KPDQKEY"/>
    <dbReference type="OrthoDB" id="2401875at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006605">
        <property type="term" value="P:protein targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.820">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00422">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023391">
        <property type="entry name" value="Prot_translocase_SecE_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008158">
        <property type="entry name" value="Translocase_Sec61-g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001901">
        <property type="entry name" value="Translocase_SecE/Sec61-g"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00327">
        <property type="entry name" value="secE_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12309">
        <property type="entry name" value="SEC61 GAMMA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00584">
        <property type="entry name" value="SecE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103456">
        <property type="entry name" value="Preprotein translocase SecE subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="87" mass="9653" checksum="4A17ACDBF6D4873F" modified="2007-04-03" version="1" fragment="single">ALIFLNMGVPDFLQDKSNPAGYVFQSAQEFALDSIRLVRRCTKPDAKEFRNVAYACTVGFFLMGFIGYSVKLVFIPINNIIMGGQAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPR6</accession>
    <name>A3FPR6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cyclin-dependent kinase 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="7">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_4850</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="4">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388412.1">
        <property type="nucleotide sequence ID" value="XM_001388375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPR6"/>
    <dbReference type="STRING" id="353152.A3FPR6"/>
    <dbReference type="GeneID" id="3371814"/>
    <dbReference type="KEGG" id="cpv:cgd7_4850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4850"/>
    <dbReference type="InParanoid" id="A3FPR6"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="1"/>
            <end position="283"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="286" mass="32275" checksum="11146326CDBD1D3A" modified="2007-04-03" version="1">MDFFIGGGTFGTVKLLRDSESGKLIVNKTANSVEKNDDLKREEALLRKLGGKHVVETYGSFMNENGLFTIILEYFPADLRKIILQGEANNFFMKKKILFGILKGIDYIHSLKIAHNDLKPENILVSKDFNIKICDFGMATETNNKIIECNKILTNLKYKSPERLLGTRNSNDLFASDMWSFGCIALELLTGKALFNGRNEIDQLFGIFRLVGTPLGTSLDYLKSLPSISESGLVLPIFKTNWDLLKLINKEDKAFFELIISSLNPSSTERITAKQALRLEIFLDFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ39</accession>
    <name>A3FQ39_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein kinase, cAMP-dependent, catalytic chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd3_3040</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388119.1">
        <property type="nucleotide sequence ID" value="XM_001388082.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ39"/>
    <dbReference type="FunCoup" id="A3FQ39">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ39"/>
    <dbReference type="GeneID" id="3373827"/>
    <dbReference type="KEGG" id="cpv:cgd3_3040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3040"/>
    <dbReference type="InParanoid" id="A3FQ39"/>
    <dbReference type="OMA" id="NDPFFDW"/>
    <dbReference type="OrthoDB" id="63267at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005952">
        <property type="term" value="C:cAMP-dependent protein kinase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004691">
        <property type="term" value="F:cAMP-dependent protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05580">
        <property type="entry name" value="STKc_PKA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000005">
        <property type="entry name" value="cAMP-dependent protein kinase catalytic subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000961">
        <property type="entry name" value="AGC-kinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353:SF37">
        <property type="entry name" value="CAMP-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT PRKX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24353">
        <property type="entry name" value="CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51285">
        <property type="entry name" value="AGC_KINASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="85"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="domain" description="AGC-kinase C-terminal" evidence="10">
        <location>
            <begin position="340"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="367"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="19"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="44"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="114"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="392" mass="45453" checksum="F85B9CE43B3435D1" modified="2007-04-03" version="1">MDGIWKRLVSGGKNHSSKEGGNSQKNAVAANNRTCENGRSLDFNTNNKSHNNPNNDTRYPATSNMNKHDTDISGNNQKKYSIDDFQLIRTLGTGSFGRVFLSKHKEDNSIYAIKRLKKSVVIRQKQVDHITNEKAILSRIKHPFLVRMFGTFKDDRYLYIMMEFVIGGEFFTYLRRCRHFDNETSRFYAAQVVLMFEYLHGKNIIYRDLKPENILIDKDGYLKLTDFGFAKAIEYRTFTLCGTPEYIAPEVLLNKGHGKPVDWWTLGILIYEMVVGFPPFYDDEPMGIYQKILAGKIFFPKYFDKNCKSLVKRLLTPDLTKRYGNLKGGVSDIKLHKWFYNYDFNSLISRKVDPPYIPKVNSYDDSSNFEEYPDSHEQPTTVTGNADPFVDW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ53</accession>
    <name>A3FQ53_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">tRNA/rRNA methyltransferase-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388189.1">
        <property type="nucleotide sequence ID" value="XM_001388152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ53"/>
    <dbReference type="STRING" id="353152.A3FQ53"/>
    <dbReference type="GeneID" id="3373430"/>
    <dbReference type="KEGG" id="cpv:cgd2_570"/>
    <dbReference type="InParanoid" id="A3FQ53"/>
    <dbReference type="OMA" id="CDHFVYI"/>
    <dbReference type="OrthoDB" id="270651at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18096">
        <property type="entry name" value="SpoU-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051259">
        <property type="entry name" value="rRNA_Methyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001537">
        <property type="entry name" value="SpoU_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191:SF7">
        <property type="entry name" value="OBP33PEP LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43191">
        <property type="entry name" value="RRNA METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00588">
        <property type="entry name" value="SpoU_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA/rRNA methyltransferase SpoU type" evidence="3">
        <location>
            <begin position="16"/>
            <end position="152"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="214" mass="24033" checksum="C05D6D855B830C0E" modified="2007-04-03" version="1">MDDIKINKDPKDLPEFYLVLSNISKRQNFGTLLRSACGFGVSEVLVVGEKKLMTFGNKGTLPHLSLTQYENIDQVVDIIKEKEMDLVGIEISDESRPIYPHPFKRSTAFLLGNEGTGLSQKYIKLCDYLIHIPLYGNGTASLNVAIAGSIVFHHFAIWAKFTESSKKGAKYIIQDDSNSNNNNNNNNHNIDISNVKGKIRHYLFPSELGTFFSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ64</accession>
    <name>A3FQ64_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">ATP synthase subunit beta</fullName>
            <ecNumber evidence="13">7.1.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd2_1360</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O + 4 H(+)(in) = ADP + phosphate + 5 H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:57720"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.1.2.2"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="13">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) and CF(0) have multiple subunits.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.2.2" evidence="13"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388200.1">
        <property type="nucleotide sequence ID" value="XM_001388163.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ64"/>
    <dbReference type="SMR" id="A3FQ64"/>
    <dbReference type="FunCoup" id="A3FQ64">
        <property type="interactions" value="153"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ64"/>
    <dbReference type="GeneID" id="3373660"/>
    <dbReference type="KEGG" id="cpv:cgd2_1360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1360"/>
    <dbReference type="InParanoid" id="A3FQ64"/>
    <dbReference type="OMA" id="SMEEGGW"/>
    <dbReference type="OrthoDB" id="14523at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042776">
        <property type="term" value="P:proton motive force-driven mitochondrial ATP synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18110">
        <property type="entry name" value="ATP-synt_F1_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18115">
        <property type="entry name" value="ATP-synt_F1_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01133">
        <property type="entry name" value="F1-ATPase_beta_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001630">
        <property type="entry name" value="ATP synthase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1140.10">
        <property type="entry name" value="Bovine Mitochondrial F1-atpase, Atp Synthase Beta Chain, Chain D, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01347">
        <property type="entry name" value="ATP_synth_beta_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005722">
        <property type="entry name" value="ATP_synth_F1_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050053">
        <property type="entry name" value="ATPase_alpha/beta_chains"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024034">
        <property type="entry name" value="ATPase_F1/V1_b/a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01039">
        <property type="entry name" value="atpD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184">
        <property type="entry name" value="ATP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15184:SF82">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT BETA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 13" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11 13" id="KW-0139">CF(1)</keyword>
    <keyword evidence="6" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="14">
        <location>
            <begin position="198"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAZ51373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="540" mass="59734" checksum="987895E281633013" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ76</accession>
    <name>A3FQ76_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_1890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388212.1">
        <property type="nucleotide sequence ID" value="XM_001388175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ76"/>
    <dbReference type="GeneID" id="3373443"/>
    <dbReference type="KEGG" id="cpv:cgd2_1890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1890"/>
    <dbReference type="InParanoid" id="A3FQ76"/>
    <dbReference type="OMA" id="NFEGHIN"/>
    <dbReference type="OrthoDB" id="342641at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="234" mass="27741" checksum="98E0D5724A1A9142" modified="2007-04-03" version="1">MFDYSKRIEHLMTNFEQISRINDENKLVKNILIKEISGIEGNIEMLKLEFYRISSRLSDSLKEKDYLEYELNKLKNKYKSTNDELNEIRNKLSARNEEYDEFKKLNECMRKEVEDLELAITLEENAISEKRKELKNLEMVSIGKETEIRKLDKLASQTISELKRKVKIREIIEDKVNAPSRSIPVKVRHVNKESKNSNHKDFKDQNKILINERGKLCSSLQNIKIKRIMAQHII</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQB3</accession>
    <name>A3FQB3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ATP-dependent RNA helicase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51312.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388135.1">
        <property type="nucleotide sequence ID" value="XM_001388098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQB3"/>
    <dbReference type="FunCoup" id="A3FQB3">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQB3"/>
    <dbReference type="GeneID" id="3371473"/>
    <dbReference type="KEGG" id="cpv:cgd1_250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_250"/>
    <dbReference type="InParanoid" id="A3FQB3"/>
    <dbReference type="OMA" id="GMPYPKQ"/>
    <dbReference type="OrthoDB" id="10261904at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF24">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="9">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="32"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="305"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51312.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="499" mass="56869" checksum="C763364B78543CB4" modified="2007-04-03" version="1">MEFLNLGLHKWVQDTCDSLKIRTPTAIQSKSIPYILKGRNVVGNAPTGSGKTLCYCLPILQILAEDPFSVFGLVLVPSRELSYQVLDQFQVFGNKVNANCQVLTGGFDESEQIHILNQKRPHILIGTPGRLSSIISYPGSNISDLLRNLRFLVLDEADRLLSESLEDDMLPILSILPKSCTGRQTLLFSATLTNAIKEIVNNYSTAPKEMKGKKPQELPMIIVNENPDDSPVEKIRQMYLFLNHRVRLVYLHYILSNVHFFNIDSVDKAKFEKNSTFFEDSQEDVDENVTFGTKNKKKFIKKQEQVIDQNKIIKQGIIFTATKQQCQMLTSCLEIMGYSVTGLHSLMNQRRRLASLGKFRSKTSKLLVATGVAARGLDIPDVEFVINYDFPRSFEDYIHRIGRVGRANKTGISLTFVTEQDVPYVYEFESKMKKEMELLKLDEDEVLKNMNRVTVAQQKALLMLEEIGFNEKNQEARERKLKVLMSKNKIPSDNKKTIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQD7</accession>
    <name>A3FQD7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 10">tRNA(His) guanylyltransferase</fullName>
            <ecNumber evidence="2 10">2.7.7.79</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">tRNA-histidine guanylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd1_1990</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end ribonucleotide-tRNA(His) + GTP + ATP + H2O = a 5'-end phospho-guanosine-ribonucleotide-tRNA(His) + AMP + 2 diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54564"/>
            <dbReference type="Rhea" id="RHEA-COMP:14193"/>
            <dbReference type="Rhea" id="RHEA-COMP:14917"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:138282"/>
            <dbReference type="ChEBI" id="CHEBI:141847"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.7.7.79"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="12">Binds 2 magnesium ions per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the tRNA(His) guanylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.79" evidence="2 10"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388159.1">
        <property type="nucleotide sequence ID" value="XM_001388122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQD7"/>
    <dbReference type="FunCoup" id="A3FQD7">
        <property type="interactions" value="276"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQD7"/>
    <dbReference type="GeneID" id="3371411"/>
    <dbReference type="KEGG" id="cpv:cgd1_1990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1990"/>
    <dbReference type="InParanoid" id="A3FQD7"/>
    <dbReference type="OMA" id="WKQHTEI"/>
    <dbReference type="OrthoDB" id="62560at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008193">
        <property type="term" value="F:tRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3000">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025845">
        <property type="entry name" value="Thg1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024956">
        <property type="entry name" value="tRNAHis_GuaTrfase_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007537">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038469">
        <property type="entry name" value="tRNAHis_GuaTrfase_Thg1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12729:SF6">
        <property type="entry name" value="TRNA(HIS) GUANYLYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04446">
        <property type="entry name" value="Thg1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14413">
        <property type="entry name" value="Thg1C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028980">
        <property type="entry name" value="tRNAHis_guanylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8 10 12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNAHis guanylyltransferase catalytic" evidence="13">
        <location>
            <begin position="6"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="domain" description="Thg1 C-terminal" evidence="14">
        <location>
            <begin position="139"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="29"/>
            <end position="34"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="29"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="75"/>
            <end position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR028980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR028980-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF04446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF14413"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAZ51336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="296" mass="35502" checksum="90190F7C92497785" modified="2007-04-03" version="1">MACSKYEYIKTYEQPSRIVKNCWFVVRIDGHSFHEFTKDHEFHKPNDKRGLDLMSRCAENVMKNLGDIVISYGQSDEFSFVFRRKTDLWSRKNDKILTHVVSLFTSSFIFFWDSFFPGKKLLYPPTFDGRIIMYPTDEDIRTYLSWRQADCHINNLYNTCFWSLVSINKLNEREATEKLKFTDSSYKNELLFKEFGINYNNISPQFRKGTTIYKARPKEKKSRDEYLLLKNNDILLFDKCKEATIETDHRDYTELDKPLNPIWKIDDEMVIISCIYKCHCDIIQDKFWHENDHLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQE1</accession>
    <name>A3FQE1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">AT hook motif protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_2240</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388163.1">
        <property type="nucleotide sequence ID" value="XM_001388126.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQE1"/>
    <dbReference type="SMR" id="A3FQE1"/>
    <dbReference type="STRING" id="353152.A3FQE1"/>
    <dbReference type="GeneID" id="3371403"/>
    <dbReference type="KEGG" id="cpv:cgd1_2240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2240"/>
    <dbReference type="InParanoid" id="A3FQE1"/>
    <dbReference type="OMA" id="CGVHMEN"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06096">
        <property type="entry name" value="Plasmepsin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033866">
        <property type="entry name" value="Plasmepsin_5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683">
        <property type="entry name" value="ASPARTYL PROTEASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683:SF375">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002653048" evidence="8">
        <location>
            <begin position="23"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="9">
        <location>
            <begin position="38"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="56"/>
        </location>
    </feature>
    <feature type="active site" evidence="6">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="7">
        <location>
            <begin position="69"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="425" mass="48444" checksum="6317679F7873579C" modified="2007-04-03" version="1">MWINKLISVILQIIIAIKLSVGRITINVHNTKDENGYYFINAFVGNPPQKQTLILDSGSSQISFTCITCINCGSHEYPPFDIMKSITGKNCNRKLLGGEKCKYFHRFNEGSVISGKYFSDTLRFEEVQQNSGIIKDHFEIKYDYLGCNELETKKIYRQRATGVFGIGLKSSLDDHVNIINSLLTSLESNTNIKGSNNLVISICLLYSGGRIVIGEQDEKITNRNSNFSENKRNHVYWVPIIYPSNVYKVSLEGLSIGSGKFSLLEEETSLFAIVDVGSTYSFFPSNLYNKIINKFSKLCELLNKLDINKCITINQSLCFSDPAKLHALLPIMNIKFGGQPNLIKWIHSSYLIKRERAWCVGIKEQTSYQNHIILGVSFMKKRQIILDPRKKRIGFNLNTTARCKYEQNKTMTNQVKLLNEYTRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQE8</accession>
    <name>A3FQE8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd1_2650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388170.1">
        <property type="nucleotide sequence ID" value="XM_001388133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQE8"/>
    <dbReference type="STRING" id="353152.A3FQE8"/>
    <dbReference type="GeneID" id="3371399"/>
    <dbReference type="KEGG" id="cpv:cgd1_2650"/>
    <dbReference type="InParanoid" id="A3FQE8"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF83">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ATP-DEPENDENT RNA HELICASE DHX16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="210"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="430"/>
            <end position="610"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="867" mass="98265" checksum="C9301670A484D7D9" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQF7</accession>
    <name>A3FQF7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Nucleolar protein 10</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_3270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388179.1">
        <property type="nucleotide sequence ID" value="XM_001388142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQF7"/>
    <dbReference type="FunCoup" id="A3FQF7">
        <property type="interactions" value="526"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQF7"/>
    <dbReference type="GeneID" id="3371390"/>
    <dbReference type="KEGG" id="cpv:cgd1_3270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3270"/>
    <dbReference type="InParanoid" id="A3FQF7"/>
    <dbReference type="OMA" id="GYFMDVR"/>
    <dbReference type="OrthoDB" id="273340at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056551">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040382">
        <property type="entry name" value="NOL10/Enp2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056550">
        <property type="entry name" value="NOL10_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14927:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23098">
        <property type="entry name" value="Beta-prop_NOL10_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23097">
        <property type="entry name" value="NOL10_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="3">
        <location>
            <begin position="14"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like N-terminal" evidence="3">
        <location>
            <begin position="266"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="Nucleolar protein 10-like second" evidence="2">
        <location>
            <begin position="427"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="527"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="551"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="561"/>
            <end position="572"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF23098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="604" mass="69657" checksum="FA1076DC72F3E8E3" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQJ9</accession>
    <name>A3FQJ9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Superoxide dismutase</fullName>
            <ecNumber evidence="8">1.15.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd5_3230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Destroys radicals which are normally produced within the cells and which are toxic to biological systems.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>2 superoxide + 2 H(+) = H2O2 + O2</text>
            <dbReference type="Rhea" id="RHEA:20696"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:18421"/>
            <dbReference type="EC" id="1.15.1.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="3">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the iron/manganese superoxide dismutase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.15.1.1" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388283.1">
        <property type="nucleotide sequence ID" value="XM_001388246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQJ9"/>
    <dbReference type="FunCoup" id="A3FQJ9">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQJ9"/>
    <dbReference type="GeneID" id="3373329"/>
    <dbReference type="KEGG" id="cpv:cgd5_3230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3230"/>
    <dbReference type="InParanoid" id="A3FQJ9"/>
    <dbReference type="OMA" id="DSLINWD"/>
    <dbReference type="OrthoDB" id="239262at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004784">
        <property type="term" value="F:superoxide dismutase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.990:FF:000002">
        <property type="entry name" value="Superoxide dismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.990">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.55.40.20">
        <property type="entry name" value="Iron/manganese superoxide dismutase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001189">
        <property type="entry name" value="Mn/Fe_SOD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019833">
        <property type="entry name" value="Mn/Fe_SOD_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019832">
        <property type="entry name" value="Mn/Fe_SOD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019831">
        <property type="entry name" value="Mn/Fe_SOD_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036324">
        <property type="entry name" value="Mn/Fe_SOD_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036314">
        <property type="entry name" value="SOD_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769">
        <property type="entry name" value="SUPEROXIDE DISMUTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42769:SF3">
        <property type="entry name" value="SUPEROXIDE DISMUTASE [FE] 2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02777">
        <property type="entry name" value="Sod_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00081">
        <property type="entry name" value="Sod_Fe_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000349">
        <property type="entry name" value="SODismutase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01703">
        <property type="entry name" value="MNSODISMTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54719">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46609">
        <property type="entry name" value="Fe,Mn superoxide dismutase (SOD), N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00088">
        <property type="entry name" value="SOD_MN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0408">Iron</keyword>
    <keyword evidence="4 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Manganese/iron superoxide dismutase N-terminal" evidence="9">
        <location>
            <begin position="27"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Manganese/iron superoxide dismutase C-terminal" evidence="10">
        <location>
            <begin position="115"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="99"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000349-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000414"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="221" mass="25471" checksum="BDB1FCF00A132B44" modified="2007-04-03" version="1">MSIRFIFNNNSKKLVNKFCRLFSGMPFELPPLPYDKKALEPVISPETLDYHYGKHHAGYVTKLNSLIKSTEFENETDLMKVIMKSSGPIYNNASQIWNHTFYWSCLRSPSETNKPTSKVSKLIEESFGSFESFKESFTANATGHFGSGWIWVVIDPINNQKLKIVQTHDGDNPEKLGLGKPVLTCDVWEHAYYIDYRNNRGSYVDQFFSIINWDFVESNLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQP5</accession>
    <name>A3FQP5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vacuolar protein-sorting protein VPS45, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_4180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STXBP/unc-18/SEC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAZ51230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388292.1">
        <property type="nucleotide sequence ID" value="XM_001388255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQP5"/>
    <dbReference type="FunCoup" id="A3FQP5">
        <property type="interactions" value="312"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQP5"/>
    <dbReference type="GeneID" id="3372564"/>
    <dbReference type="KEGG" id="cpv:cgd5_4180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4180"/>
    <dbReference type="InParanoid" id="A3FQP5"/>
    <dbReference type="OMA" id="XGRSTES"/>
    <dbReference type="OrthoDB" id="10266265at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.830.10">
        <property type="entry name" value="Syntaxin Binding Protein 1, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043127">
        <property type="entry name" value="Sec-1-like_dom3a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001619">
        <property type="entry name" value="Sec1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036045">
        <property type="entry name" value="Sec1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11679">
        <property type="entry name" value="VESICLE PROTEIN SORTING-ASSOCIATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00995">
        <property type="entry name" value="Sec1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56815">
        <property type="entry name" value="Sec1/munc18-like (SM) proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="418" mass="48870" checksum="33D24996D69B9000" modified="2007-04-03" version="1">MYNLPSSWTTYEETLFSRMIEGIYSASLQLGEIPVIRYLANSPLCRNIAFAVERRLLDSNLIDLVSGEFVNTRSESYDDKRNESTILLILDRREDPVTPLLTQWTYHAMIHELLEIKNNRLCLDNGGFSNKEKEEYVLSEQYDDFFRDHKYDNFGDIGFSIRDLVNNHHESSKTNHRLETIDDISRFVQMYPDFKKEYNNIYKHVNILHELSRIVQERDLMRISALEQDLTVCDNVDEHSRQIGNLLSDTRISQFDKLRLALLYSLKYEKEEIQINNFKYHLGTQANYIDKLLQVFGENFRSGDLFLNKTLLNIAKNTINKSNNNNIYIQHKTLLYYILENLVKGKLKNSRFPSTTDDYNSSKKPLKIMVFVVGGVTLEESRDVNVIRNLYDVDIILGGTNLLNSKLFIKDLELLINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPE3</accession>
    <name>Q5CPE3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_4610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000017">
        <property type="protein sequence ID" value="EAK87298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625309.1">
        <property type="nucleotide sequence ID" value="XM_625309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPE3"/>
    <dbReference type="STRING" id="353152.Q5CPE3"/>
    <dbReference type="GeneID" id="3372311"/>
    <dbReference type="KEGG" id="cpv:cgd5_4610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4610"/>
    <dbReference type="InParanoid" id="Q5CPE3"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="259" mass="29923" checksum="E37F2455F468CB3B" modified="2005-04-12" version="1">MFIKNKILLLLLLLLLFINFLFFFENITDNFLFKKDVSLIKIRNETPNEGSSSSGNKNSEGLSRGGGEGGGDRGKKKPVLRMMKSFPFKGSEKSSHCHHHHHHHHKDKHCKGKKHTIIHQHIPGKTSGKKVIVAMPTLRMKDPDDPSSYPSDMPSDEPSHNPDDDEESCDDDDDDYNDDDDDDDEEQCDDEEEEEERYQREKEKEEHENKHDQLDSGKKRRRKRKARKSKSNLRSRGSGKHFSEKICGPCKNINMEDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPJ0</accession>
    <name>Q5CPJ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oocyst wall protein 8</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625359.1">
        <property type="nucleotide sequence ID" value="XM_625359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPJ0"/>
    <dbReference type="STRING" id="353152.Q5CPJ0"/>
    <dbReference type="GeneID" id="3375640"/>
    <dbReference type="KEGG" id="cpv:cgd6_200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_200"/>
    <dbReference type="InParanoid" id="Q5CPJ0"/>
    <dbReference type="OMA" id="CHHSVSL"/>
    <dbReference type="OrthoDB" id="338192at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254078" evidence="1">
        <location>
            <begin position="23"/>
            <end position="457"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="457" mass="49991" checksum="12DF31F5F37538F9" modified="2007-04-03" version="1">MISLRKINTIIMMAMLPLSCYAGDHHHHHQQQAVSTVSVVNVPTMVCPTGYTLDSNRQCVAREEIMPERVCLNGGELMSDFNCMKTTNPIMKCPVEYTLVGENMCQKNVEIDPVAVCPSGFTLTDGQMCSGSKTVAPIKKCMQGVLNEMQNECILQKSVSPISTCPSPDFTLVSNERCVREVLYDCTPAATAVRYTTTSHHGHGHGHHHHQTSYVVPQAVVSRTCSRSESVPAQMICPEGAVKSLTGFGCLYTSTTEPTLGCANGSMVANGECVEVITVPAELECPNPTPKPTNEFYDGKYYSLRNSPQQSVKSLGYGSQYVYEQGSQNFNQPAGIITRRLGKRGVSHHHHHNAYYPIQTYVQQTYVQPIPVIQEVPRKKCFDTQTVPGELGCPVGYTDGDKGLCKSIVPSTLNCPSGTTLNANGTCIRNVVVQPTMASQQQEIIQTTITGGRHHHH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPJ2</accession>
    <name>Q5CPJ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_180</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625357.1">
        <property type="nucleotide sequence ID" value="XM_625357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPJ2"/>
    <dbReference type="STRING" id="353152.Q5CPJ2"/>
    <dbReference type="GeneID" id="3375638"/>
    <dbReference type="KEGG" id="cpv:cgd6_180"/>
    <dbReference type="InParanoid" id="Q5CPJ2"/>
    <dbReference type="OMA" id="YSIAESW"/>
    <dbReference type="OrthoDB" id="343448at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005672">
        <property type="term" value="C:transcription factor TFIIA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.18.10">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009088">
        <property type="entry name" value="TFIIA_b-brl"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50784">
        <property type="entry name" value="Transcription factor IIA (TFIIA), beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="142"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="230"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="142"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="236"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="270"/>
            <end position="279"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="333" mass="38120" checksum="F3A0E73FB7C7F3F7" modified="2005-04-12" version="1">MLEQLKLRWISKLNDLCLGVTKDEKSDRNQEWVPTEMEVIAPKLDGVLPVKIESVPKKSDISEISNNINYGNINNHHNDSISEFNSNEIIVCDNRINNKRFSEGSLQSIPTPIISSKEMRNVNELNIEYDFCKMVSKKSKLDDSDSKYVGNEDEKDIEKEEEEGKERNAFLEEKQNTTCEQFNTEKCQNSNGNENNNNDEFEDDEFGDASWDVVAPSESESTKDNLTDNFQEQNKSKSNNQNSTTNGQISGNNDHFDEEILSDPGSDLENVSDLDDEEPECSDVIIGHFEKVIRPYTRKKNQKGKWRVKLRNGIAQIANQEIPFDTLIGEFEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPK7</accession>
    <name>Q5CPK7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Inosine-5-monophosphate dehydrogenase</fullName>
            <ecNumber evidence="15">1.1.1.205</ecNumber>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd6_20</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="17" key="2">
        <citation type="journal article" date="2010" name="J. Am. Chem. Soc." volume="132" first="1230" last="1231">
            <title>The structural basis of Cryptosporidium-specific IMP dehydrogenase inhibitor selectivity.</title>
            <authorList>
                <person name="Macpherson I.S."/>
                <person name="Kirubakaran S."/>
                <person name="Gorla S.K."/>
                <person name="Riera T.V."/>
                <person name="D'Aquino J.A."/>
                <person name="Zhang M."/>
                <person name="Cuny G.D."/>
                <person name="Hedstrom L."/>
            </authorList>
            <dbReference type="PubMed" id="20052976"/>
            <dbReference type="DOI" id="10.1021/ja909947a"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 3-91 AND 137-402 IN COMPLEX WITH IMP</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>IMP + NAD(+) + H2O = XMP + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11708"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57464"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
            <dbReference type="EC" id="1.1.1.205"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the IMPDH/GMPR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.205" evidence="15"/>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625342.1">
        <property type="nucleotide sequence ID" value="XM_625342.1"/>
    </dbReference>
    <dbReference type="PDB" id="3KHJ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.80 A"/>
        <property type="chains" value="A/B/C/D/E/F/G/H=3-91, A/B/C/D/E/F/G/H=137-402"/>
    </dbReference>
    <dbReference type="PDBsum" id="3KHJ"/>
    <dbReference type="AlphaFoldDB" id="Q5CPK7"/>
    <dbReference type="SMR" id="Q5CPK7"/>
    <dbReference type="FunCoup" id="Q5CPK7">
        <property type="interactions" value="221"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPK7"/>
    <dbReference type="BindingDB" id="Q5CPK7"/>
    <dbReference type="GeneID" id="3375651"/>
    <dbReference type="KEGG" id="cpv:cgd6_20"/>
    <dbReference type="InParanoid" id="Q5CPK7"/>
    <dbReference type="OMA" id="PGSHCTT"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CPK7"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003938">
        <property type="term" value="F:IMP dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006177">
        <property type="term" value="P:GMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006183">
        <property type="term" value="P:GTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00381">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000424">
        <property type="entry name" value="Inosine-5'-monophosphate dehydrogenase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005990">
        <property type="entry name" value="IMP_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015875">
        <property type="entry name" value="IMP_DH/GMP_Rdtase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001093">
        <property type="entry name" value="IMP_DH_GMPRt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911:SF111">
        <property type="entry name" value="INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11911">
        <property type="entry name" value="INOSINE-5-MONOPHOSPHATE DEHYDROGENASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00478">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000130">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01240">
        <property type="entry name" value="IMPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51412">
        <property type="entry name" value="Inosine monophosphate dehydrogenase (IMPDH)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00487">
        <property type="entry name" value="IMP_DH_GMP_RED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="17" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-0332">GMP biosynthesis</keyword>
    <keyword evidence="7 11" id="KW-0520">NAD</keyword>
    <keyword evidence="6 15" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5 12" id="KW-0630">Potassium</keyword>
    <keyword evidence="4" id="KW-0658">Purine biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="IMP dehydrogenase/GMP reductase" evidence="14">
        <location>
            <begin position="11"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="98"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="98"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="active site" description="Thioimidate intermediate" evidence="9">
        <location>
            <position position="221"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="317"/>
        </location>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="165"/>
            <end position="167"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="214"/>
            <end position="216"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="216"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 17">
        <location>
            <position position="219"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" description="in other chain" evidence="12">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>K(+)</name>
            <dbReference type="ChEBI" id="CHEBI:29103"/>
            <note>ligand shared between two tetrameric partners</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="254"/>
            <end position="256"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="254"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="256"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="277"/>
            <end position="278"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="278"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="301"/>
            <end position="305"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="301"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="17">
        <location>
            <position position="305"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10 17">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>IMP</name>
            <dbReference type="ChEBI" id="CHEBI:58053"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR000130-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK87356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="3KHJ"/>
        </source>
    </evidence>
    <sequence length="402" mass="43282" checksum="51858B059C00FF24" modified="2005-04-12" version="1" fragment="single">SNMGTKNIGKGLTFEDILLVPNYSEVLPREVSLETKLTKNVSLKIPLISSAMDTVTEHLMAVGMARLGGIGIIHKNMDMESQVNEVLKVKNWISNLEKNESTPDQNLDKESTDGKDTKSNNNIDAYSNENLDNKGRLRVGAAIGVNEIERAKLLVEAGVDVIVLDSAHGHSLNIIRTLKEIKSKMNIDVIVGNVVTEEATKELIENGADGIKVGIGPGSICTTRIVAGVGVPQITAIEKCSSVASKFGIPIIADGGIRYSGDIGKALAVGASSVMIGSILAGTEESPGEKELIGDTVYKYYRGMGSVGAMKSGSGDRYFQEKRPENKMVPEGIEGRVKYKGEMEGVVYQLVGGLRSCMGYLGSASIEELWKKSSYVEITTSGLRESHVHDVEIVKEVMNYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPM1</accession>
    <name>Q5CPM1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Nucleoside transporter, 10 transmembrane domain domain, nucleoside binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625400.1">
        <property type="nucleotide sequence ID" value="XM_625400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPM1"/>
    <dbReference type="SMR" id="Q5CPM1"/>
    <dbReference type="STRING" id="353152.Q5CPM1"/>
    <dbReference type="GeneID" id="3372385"/>
    <dbReference type="KEGG" id="cpv:cgd2_310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_310"/>
    <dbReference type="InParanoid" id="Q5CPM1"/>
    <dbReference type="OMA" id="ARGMNEF"/>
    <dbReference type="OrthoDB" id="427043at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005337">
        <property type="term" value="F:nucleoside transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002259">
        <property type="entry name" value="Eqnu_transpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10332:SF10">
        <property type="entry name" value="EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01733">
        <property type="entry name" value="Nucleoside_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01130">
        <property type="entry name" value="DERENTRNSPRT"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="33"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="169"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="352"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="383"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="425"/>
            <end position="446"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="449" mass="50521" checksum="DEC6EDB56BC976FA" modified="2007-04-03" version="1">MKSERLENSSTASIPYFTSLFQSGGLIPKRERLYARLVFITFGIASLFMWNTYLSCYGILNKQLFPGMGFIQYVQTSYMTSVFIGNLTMVFGLTHIFDPHHCTVIFNCVGALQSSIICLSVWLLHGTYLGCSLNILIAGLVAFSCAILIPETFTLAAIMPESFCSDVSLGQSFSGAITFTLTIILDIFIPHDIQGRKLLVTVMFALSTIISLFAAFLAQSLTKSPWCYSAIAEIRRKSNSSTLISVNQYRNDSQLSYEDSLVSVPISLETENSFECRSTHLEVTRQIWPQLYNIFMSFMVTLAVFPTICAEWDTFLPEKYSNILMVILVGMFHLGDMLGRHVPKFGFTIPPSLLWILTTSRLAFIPLYAAIKNASYDSFLASIWTKIIVQFFLAFTNGLSAYLAFIYGPETVYFRHNKEKASFLLAIYNVAGMTAGSWLMNLLVWVKYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPM2</accession>
    <name>Q5CPM2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kelch repeat-containing proteins that is fused to a HSP90-like ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_300</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625399.1">
        <property type="nucleotide sequence ID" value="XM_625399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPM2"/>
    <dbReference type="FunCoup" id="Q5CPM2">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="GeneID" id="3372356"/>
    <dbReference type="KEGG" id="cpv:cgd2_300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_300"/>
    <dbReference type="InParanoid" id="Q5CPM2"/>
    <dbReference type="OMA" id="IGPRSHY"/>
    <dbReference type="OrthoDB" id="10251809at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093">
        <property type="entry name" value="ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46093:SF18">
        <property type="entry name" value="FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1097"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1097"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1109"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1248" mass="141198" checksum="C48A62FED4981C2F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPU9</accession>
    <name>Q5CPU9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625415.1">
        <property type="nucleotide sequence ID" value="XM_625415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPU9"/>
    <dbReference type="FunCoup" id="Q5CPU9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPU9"/>
    <dbReference type="GeneID" id="3372427"/>
    <dbReference type="KEGG" id="cpv:cgd4_3940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3940"/>
    <dbReference type="InParanoid" id="Q5CPU9"/>
    <dbReference type="OMA" id="SEDTNCD"/>
    <dbReference type="OrthoDB" id="344309at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008157">
        <property type="term" value="F:protein phosphatase 1 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004865">
        <property type="term" value="F:protein serine/threonine phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011107">
        <property type="entry name" value="PPI_Ypi1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20835">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE PPP1R11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07491">
        <property type="entry name" value="PPI_Ypi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="19"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="93"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="22"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="127" mass="14362" checksum="E0B640ED2B0570D7" modified="2005-04-12" version="1">MSQTIYKTNTLTILKVEDNDKLNNSSDNTNNNSKIEDKEEIIQDSNINNDLDYKKIHRKSTNSVTWDESAIDNEMMNKKKSKKCCIFHKKRNFGESSSSESDSDSESDSDSESDSSSSCNNKCGKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPX9</accession>
    <name>Q5CPX9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein phosphatase inhibitor 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625500.1">
        <property type="nucleotide sequence ID" value="XM_625500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPX9"/>
    <dbReference type="FunCoup" id="Q5CPX9">
        <property type="interactions" value="39"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPX9"/>
    <dbReference type="GeneID" id="3372449"/>
    <dbReference type="KEGG" id="cpv:cgd8_390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_390"/>
    <dbReference type="InParanoid" id="Q5CPX9"/>
    <dbReference type="OMA" id="HYDEYKT"/>
    <dbReference type="OrthoDB" id="551302at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004864">
        <property type="term" value="F:protein phosphatase inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009966">
        <property type="term" value="P:regulation of signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007062">
        <property type="entry name" value="PPI-2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398:SF20">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY INHIBITOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12398">
        <property type="entry name" value="PROTEIN PHOSPHATASE INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04979">
        <property type="entry name" value="IPP-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="180" mass="20545" checksum="A0B0322B1CA33D3C" modified="2005-04-12" version="1">MSEKEKFNIHLKEDKVKISKCITWDEETIAMHDAERGTRMEINEPDTPYYYGSSSSSDYEEPNTKSKVRQKFSVDLNELSSKLFEHSNRIDESLDEFSFSNFNNNTSSPIHKSKQDLFKEKRKMHYREFITAKSKLPKANDSDSSSSSGSNSNSNSDSDSDSDSDSNSGSKPYSNYKPKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPZ4</accession>
    <name>Q5CPZ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Transcription factor TFIID, TBP</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625485.1">
        <property type="nucleotide sequence ID" value="XM_625485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPZ4"/>
    <dbReference type="STRING" id="353152.Q5CPZ4"/>
    <dbReference type="GeneID" id="3372468"/>
    <dbReference type="KEGG" id="cpv:cgd8_210"/>
    <dbReference type="InParanoid" id="Q5CPZ4"/>
    <dbReference type="OMA" id="EVHNIQA"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="195" mass="22157" checksum="3B8C709B40AC6487" modified="2005-04-12" version="1" fragment="single">HLIYCIFRADIPDKHTKSVVTVSAFSNGKIQATGGVSVECTKNSLKKIVRKLRSKGFEKAKLLSFEVHNIQAVIDAGFPIDLRVLREIYVFVDYEPERNPGLRIRIPVLYLYNQGCNPEFLQRQLLAHQYGNVNQNKGRLERANNPAFFRNGKIEIVTLTIHFSGKIGMAGGRSVEGLQKVLEYIKPYLIRSRLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ38</accession>
    <name>Q5CQ38_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_4260</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat UTP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625588.1">
        <property type="nucleotide sequence ID" value="XM_625588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ38"/>
    <dbReference type="STRING" id="353152.Q5CQ38"/>
    <dbReference type="GeneID" id="3372573"/>
    <dbReference type="KEGG" id="cpv:cgd5_4260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4260"/>
    <dbReference type="InParanoid" id="Q5CQ38"/>
    <dbReference type="OMA" id="DLNRATY"/>
    <dbReference type="OrthoDB" id="1935146at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045161">
        <property type="entry name" value="Utp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359:SF0">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18359">
        <property type="entry name" value="WD-REPEAT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="294"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="491" mass="56050" checksum="ABD5CF2BDA8C44C2" modified="2005-04-12" version="1">MEEVQKVQKSSRVWCDSDDENVEIDISDNLKLRKLRKVDGEKSIDGKEYSKRLREFHQNKVFKTKGNEWIYKARKEIFESVDTDHLDQESVNNIKSDSLSNLETFNKVKTGKIYKYIQDYKSRKNDKLIKSGKSIISQSKIDIKRLTNANIQSPSGCVVKSLEFHKGQHIENGNNVSLLSVSGWDKKIKLFNVDGIENKLISSLFFDDFPIYESRFTSSTEEMMFLGPRARIGVFDLLEGKINFLPGIAGRKDKRYWNLTIQKSEGLDKSYIGLSTSNGTILVLDEQTKQLVRSFKMNDSVTGLAFHPLENDKIISTSNTGEIYIWDINTGRCRERIVDYGSLCITSIVSSYKSKVQRRAISSSYIMTGSTTGFVNIYSLDDNIQKTQDKSENPNINSIFKTPRFTIDNICTSITSMAIHPRNEIAAISSKWTKDSLKLINLYTGHVYSNWPTARTPLKYVTSMDFSEYGGYLATGNDKGDVLLYRINDYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ45</accession>
    <name>Q5CQ45_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_4190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625581.1">
        <property type="nucleotide sequence ID" value="XM_625581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ45"/>
    <dbReference type="GeneID" id="3372565"/>
    <dbReference type="KEGG" id="cpv:cgd5_4190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4190"/>
    <dbReference type="InParanoid" id="Q5CQ45"/>
    <dbReference type="OMA" id="CHISMIN"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.50.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046357">
        <property type="entry name" value="PPIase_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54534">
        <property type="entry name" value="FKBP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="748" mass="86655" checksum="BDC99F902EB7FD9A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ69</accession>
    <name>Q5CQ69_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625557.1">
        <property type="nucleotide sequence ID" value="XM_625557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ69"/>
    <dbReference type="GeneID" id="3372601"/>
    <dbReference type="KEGG" id="cpv:cgd5_3930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3930"/>
    <dbReference type="InParanoid" id="Q5CQ69"/>
    <dbReference type="OrthoDB" id="337835at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254110" evidence="1">
        <location>
            <begin position="24"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="174" mass="20228" checksum="EF958AF656B6E2CF" modified="2005-04-12" version="1">MKIKSFVAILVIKGLLLTTRVNSCGIHDLDINDENSNCKNSYFEITEEISLNSLDSLKLNELIFDSIELIINQIKWRFEKDHERYLSESQKSLSFVNNISLDERIDNYIKNANFLTGEEIKKGVLQILKNYQKNDKLNNFDSSNRIIHSEVIENNKIPLNQGFINLVVFPNEYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ79</accession>
    <name>Q5CQ79_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625547.1">
        <property type="nucleotide sequence ID" value="XM_625547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ79"/>
    <dbReference type="GeneID" id="3372592"/>
    <dbReference type="KEGG" id="cpv:cgd5_3830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3830"/>
    <dbReference type="InParanoid" id="Q5CQ79"/>
    <dbReference type="OMA" id="FKFQNKN"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="33"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="47"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="66"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="179" mass="21376" checksum="7CEE99746801E3EE" modified="2005-04-12" version="1">MDELKSKIEPNERHIEIHSNELEVNTETIDEIEQSKNHDKNLESDYQHQNQNPVLNQEQEQDQEEQNQKEQDQIEDQYKSETDIETRQKECEIDNELYIQNDCIYGDEDVKLYNNNNNDNNNQLDRKISDIYTNHMDNNSDHQLETSDYEQEPNDFNDSNNIDDHNSALFSEEIPINQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQI0</accession>
    <name>Q5CQI0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular protein with a signal peptide, FN3 domain and a predicted transmembrane region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625668.1">
        <property type="nucleotide sequence ID" value="XM_625668.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQI0"/>
    <dbReference type="GeneID" id="3372751"/>
    <dbReference type="KEGG" id="cpv:cgd4_640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_640"/>
    <dbReference type="InParanoid" id="Q5CQI0"/>
    <dbReference type="OMA" id="HRISIFN"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00063">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003961">
        <property type="entry name" value="FN3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036116">
        <property type="entry name" value="FN3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00041">
        <property type="entry name" value="fn3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49265">
        <property type="entry name" value="Fibronectin type III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50853">
        <property type="entry name" value="FN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254122" evidence="2">
        <location>
            <begin position="23"/>
            <end position="2430"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2400"/>
            <end position="2426"/>
        </location>
    </feature>
    <feature type="domain" description="Fibronectin type-III" evidence="3">
        <location>
            <begin position="1568"/>
            <end position="1666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2430" mass="284242" checksum="C9177DCC1C1EFB16" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQJ0</accession>
    <name>Q5CQJ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">26S proteasome regulatory subunit 5a with a vWA domain and two ubiquitin interacting motifs (UIM)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd4_530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S5A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625658.1">
        <property type="nucleotide sequence ID" value="XM_625658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQJ0"/>
    <dbReference type="FunCoup" id="Q5CQJ0">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQJ0"/>
    <dbReference type="GeneID" id="3372727"/>
    <dbReference type="KEGG" id="cpv:cgd4_530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_530"/>
    <dbReference type="InParanoid" id="Q5CQJ0"/>
    <dbReference type="OMA" id="QMSMQDQ"/>
    <dbReference type="OrthoDB" id="1731724at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.410:FF:000005">
        <property type="entry name" value="26S proteasome non-ATPase regulatory subunit 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3990">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027040">
        <property type="entry name" value="PSMD4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002035">
        <property type="entry name" value="VWF_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10223:SF0">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13519">
        <property type="entry name" value="VWA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00726">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50234">
        <property type="entry name" value="VWFA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VWFA" evidence="4">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="237"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="302"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="302"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="360"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="383" mass="41494" checksum="D207DC4E90B273B0" modified="2005-04-12" version="1">MTLEATVICLDNSNYSRNGDYGTSRMLQQQDATNFISGIKTQQNPENLVGILSMAGERIELRVTPTSDLSKTMHAMDGIRLNGKIDLLRGIQIAQLALKHRLNKNLRQRIVCFVGSPLEDDLTEKQLEKLGKVLKKNNVSIDIISFGEILVNRERLQALVNAANNDNTSNFVEVAAPTNLTDALMASPIVLGEGTSSGVYADGLAGAAGETSGFEFGIDPNADPELYMALRMSMEEERNRQMRLEGNTEGNPSSAEPANSAQGQSTTNNFDSIPTINEINAMEVDDELRQALLLSIQDFSGNDSTNNTNTSNQQQGTSTSENTSNTSTNPNQGNNAQAGSTSDPNSIEGLIQGIPGVDINDPRIQDALRQLNKSDSEDKKDKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQL1</accession>
    <name>Q5CQL1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625637.1">
        <property type="nucleotide sequence ID" value="XM_625637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQL1"/>
    <dbReference type="STRING" id="353152.Q5CQL1"/>
    <dbReference type="GeneID" id="3372662"/>
    <dbReference type="KEGG" id="cpv:cgd4_290"/>
    <dbReference type="InParanoid" id="Q5CQL1"/>
    <dbReference type="OMA" id="IMPRRSC"/>
    <dbReference type="OrthoDB" id="10264446at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000331">
        <property type="entry name" value="Phosphoprotein phosphatase, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002554">
        <property type="entry name" value="PP2A_B56"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10257:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 56 KDA REGULATORY SUBUNIT GAMMA ISOFORM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01603">
        <property type="entry name" value="B56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="176"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="51"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="176"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="691" mass="79038" checksum="8B06A6BB737B1AD9" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQU1</accession>
    <name>Q5CQU1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Noc3 like protein involved in nuclear export of pre-ribosomes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_3320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625911.1">
        <property type="nucleotide sequence ID" value="XM_625911.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQU1"/>
    <dbReference type="STRING" id="353152.Q5CQU1"/>
    <dbReference type="GeneID" id="3372779"/>
    <dbReference type="KEGG" id="cpv:cgd4_3320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3320"/>
    <dbReference type="InParanoid" id="Q5CQU1"/>
    <dbReference type="OMA" id="NIALLEC"/>
    <dbReference type="OrthoDB" id="10263597at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011501">
        <property type="entry name" value="Noc3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016903">
        <property type="entry name" value="Nucleolar_cplx-assoc_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14428:SF5">
        <property type="entry name" value="NUCLEOLAR COMPLEX PROTEIN 3 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07540">
        <property type="entry name" value="NOC3p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleolar complex-associated protein 3 N-terminal" evidence="2">
        <location>
            <begin position="114"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="695" mass="79973" checksum="A3FBC73B74053623" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQV5</accession>
    <name>Q5CQV5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 6</fullName>
            <shortName evidence="6">eIF-6</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="primary">EIF6</name>
        <name evidence="7" type="ORF">cgd4_3130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Monomer. Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
            <location evidence="6">Nucleolus</location>
        </subcellularLocation>
        <text evidence="6">Shuttles between cytoplasm and nucleus/nucleolus.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the eIF-6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625897.1">
        <property type="nucleotide sequence ID" value="XM_625897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQV5"/>
    <dbReference type="FunCoup" id="Q5CQV5">
        <property type="interactions" value="425"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQV5"/>
    <dbReference type="GeneID" id="3372790"/>
    <dbReference type="KEGG" id="cpv:cgd4_3130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3130"/>
    <dbReference type="InParanoid" id="Q5CQV5"/>
    <dbReference type="OMA" id="WCAFCGM"/>
    <dbReference type="OrthoDB" id="4155914at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00527">
        <property type="entry name" value="IF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.75.10.10:FF:000006">
        <property type="entry name" value="Eukaryotic translation initiation factor 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.75.10.10">
        <property type="entry name" value="L-arginine/glycine Amidinotransferase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00032">
        <property type="entry name" value="eIF_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002769">
        <property type="entry name" value="eIF6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00323">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10784">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01912">
        <property type="entry name" value="eIF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006413">
        <property type="entry name" value="IF-6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00654">
        <property type="entry name" value="eIF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55909">
        <property type="entry name" value="Pentein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 6 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0690">Ribosome biogenesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="252" mass="27397" checksum="2805CC0AAF2819AD" modified="2005-04-12" version="1">MALRVAYESSSEIGVFANLTNRYCLLAHGSSAAFTSVFEAELMDHIPIINTLIGGTRLVGRCTVGNRNGLLVSNMATDQELQHLRNSLPDNVKVQRIEERLSALGNCIACNDYVALIHTDMDKESEEIIQDVLGVEVFRTTIAGHVLVGSYAKFTNQGGIVHTLASEDEMNELSALLQIPITSGTVNRGSDVVSAGCVVNDWAGFVGMETTAAEMAVIERIFKLGTYSNVNNQEEMREKDIKLKSSIIDTLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQZ4</accession>
    <name>Q5CQZ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative coiled-coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625858.1">
        <property type="nucleotide sequence ID" value="XM_625858.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQZ4"/>
    <dbReference type="GeneID" id="3372840"/>
    <dbReference type="KEGG" id="cpv:cgd4_2730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2730"/>
    <dbReference type="InParanoid" id="Q5CQZ4"/>
    <dbReference type="OMA" id="DMETKNR"/>
    <dbReference type="OrthoDB" id="342134at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="24"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="282"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="386"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="449"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="724"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="24"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="987" mass="115543" checksum="0DF3CA5BA6A2801F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQZ6</accession>
    <name>Q5CQZ6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">NADPH--hemoprotein reductase</fullName>
            <ecNumber evidence="8">1.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_2700</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FMN</name>
            <dbReference type="ChEBI" id="CHEBI:58210"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.6.2.4" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87834.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625856.1">
        <property type="nucleotide sequence ID" value="XM_625856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQZ6"/>
    <dbReference type="FunCoup" id="Q5CQZ6">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQZ6"/>
    <dbReference type="GeneID" id="3372841"/>
    <dbReference type="KEGG" id="cpv:cgd4_2700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2700"/>
    <dbReference type="InParanoid" id="Q5CQZ6"/>
    <dbReference type="OMA" id="MTPTRIH"/>
    <dbReference type="OrthoDB" id="1688044at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003958">
        <property type="term" value="F:NADPH-hemoprotein reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.360">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.990.10">
        <property type="entry name" value="NADPH-cytochrome p450 Reductase, Chain A, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.80">
        <property type="entry name" value="Nucleotide-binding domain of ferredoxin-NADP reductase (FNR) module"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003097">
        <property type="entry name" value="CysJ-like_FAD-binding"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001094">
        <property type="entry name" value="Flavdoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008254">
        <property type="entry name" value="Flavodoxin/NO_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001709">
        <property type="entry name" value="Flavoprot_Pyr_Nucl_cyt_Rdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029039">
        <property type="entry name" value="Flavoprotein-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039261">
        <property type="entry name" value="FNR_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023173">
        <property type="entry name" value="NADPH_Cyt_P450_Rdtase_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001433">
        <property type="entry name" value="OxRdtase_FAD/NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017938">
        <property type="entry name" value="Riboflavin_synthase-like_b-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384:SF17">
        <property type="entry name" value="NADPH--CYTOCHROME P450 REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19384">
        <property type="entry name" value="NITRIC OXIDE SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00667">
        <property type="entry name" value="FAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00258">
        <property type="entry name" value="Flavodoxin_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00175">
        <property type="entry name" value="NAD_binding_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00369">
        <property type="entry name" value="FLAVODOXIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00371">
        <property type="entry name" value="FPNCR"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52343">
        <property type="entry name" value="Ferredoxin reductase-like, C-terminal NADP-linked domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52218">
        <property type="entry name" value="Flavoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63380">
        <property type="entry name" value="Riboflavin synthase domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50902">
        <property type="entry name" value="FLAVODOXIN_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0288">FMN</keyword>
    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="7" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavodoxin-like" evidence="9">
        <location>
            <begin position="45"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022643"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87834.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="651" mass="74662" checksum="4B3FC2BD6814599B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR37</accession>
    <name>Q5CR37_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative phosphopantothenoylcysteine synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_2250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625815.1">
        <property type="nucleotide sequence ID" value="XM_625815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR37"/>
    <dbReference type="FunCoup" id="Q5CR37">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR37"/>
    <dbReference type="GeneID" id="3372950"/>
    <dbReference type="KEGG" id="cpv:cgd4_2250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2250"/>
    <dbReference type="InParanoid" id="Q5CR37"/>
    <dbReference type="OMA" id="LERYQHH"/>
    <dbReference type="OrthoDB" id="70224at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10300">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035929">
        <property type="entry name" value="CoaB-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102645">
        <property type="entry name" value="CoaB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="308" mass="35343" checksum="8C282D2B5E5B93F4" modified="2005-04-12" version="1">MESIKLRPNKINLSEFILREIKIHNRNIVVITSGGTYVPLEKNMVRYIDNFSTGTRGAQSAEYFLKSGFSVIFFHRKGSHIPFTIDCPSKYDMLMAIANNIVSLNGDHFNLLINERFKKVIEASQNLTKYSDRMFLMEFGSVHEYFNGVDYITSHCTEFPGNFIFFLAAAVSDFYIPENLLPKNKISSSSGISLDLENEPKTPSITLELYSTPKYARYIRNKLPLCFLVLFKLETEYEILFKKSDNLLKICDANVICANLLQDRRDHVIILTANSKTEIKKMSGPIEEAIVSNIISLYENYSLNNTRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR73</accession>
    <name>Q5CR73_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RNase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_1850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625779.1">
        <property type="nucleotide sequence ID" value="XM_625779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR73"/>
    <dbReference type="SMR" id="Q5CR73"/>
    <dbReference type="FunCoup" id="Q5CR73">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR73"/>
    <dbReference type="GeneID" id="3372900"/>
    <dbReference type="KEGG" id="cpv:cgd4_1850"/>
    <dbReference type="InParanoid" id="Q5CR73"/>
    <dbReference type="OMA" id="STHEGCA"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050410">
        <property type="entry name" value="CCR4/nocturin_mRNA_transcr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121:SF37">
        <property type="entry name" value="2',5'-PHOSPHODIESTERASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12121">
        <property type="entry name" value="CARBON CATABOLITE REPRESSOR PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="689" mass="80554" checksum="FEBE2BB5DBEFE823" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRQ2</accession>
    <name>Q5CRQ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pleckstrin homology (PH) domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626134.1">
        <property type="nucleotide sequence ID" value="XM_626134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRQ2"/>
    <dbReference type="GeneID" id="3373268"/>
    <dbReference type="KEGG" id="cpv:cgd5_1920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1920"/>
    <dbReference type="InParanoid" id="Q5CRQ2"/>
    <dbReference type="OrthoDB" id="335979at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="208" mass="23223" checksum="FC075A28E226FB73" modified="2005-04-12" version="1">MDLSHNKRRFSIEFEDVQKSIVFHVCDSSMDRGLWTGAIQAHLKKAIEVRHRTGHHIDWRALEFEVCRIRYESGIKGKFWRCSTEAHNRMYEVHPPRHEIASFGSLNSVIWGSDGYKRNNSVLSTGSVIEPGTGTATSGCWNRRRTGSIASSTAGAFGNKYRAPSISGLSDCNLLRKDSVNIVGVTTCSGASGTYPGNSRRHSTERQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRV1</accession>
    <name>Q5CRV1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F11M21.28-like protein having 3 CCCH RNA binding domains involved in RNA metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_1380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626085.1">
        <property type="nucleotide sequence ID" value="XM_626085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRV1"/>
    <dbReference type="GeneID" id="3373290"/>
    <dbReference type="KEGG" id="cpv:cgd5_1380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1380"/>
    <dbReference type="InParanoid" id="Q5CRV1"/>
    <dbReference type="OrthoDB" id="20534at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045234">
        <property type="entry name" value="Unkempt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493:SF50">
        <property type="entry name" value="RING FINGER PROTEIN UNKEMPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493">
        <property type="entry name" value="UNKEMPT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="57"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="13"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="57"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="351" mass="40888" checksum="01797727769938FF" modified="2005-04-12" version="1">MANALLSIEELTRFRTKLCRRSLREGCDFGPLRCQYSHNVYWPRRCPFYLSDRSALRYLPDICPDITILDHETGKVANFCNRGGYCPYSHSMEEVIYHPLIYKSELCTAFQKGECKTYYCHLIHGLAERRQERIYTLPFTRGINLNKYPNVKLVEKTTSESENTAKSSMFSGNKNDEITNLEIITSHDRNSGVTKQKSLKCIHDSENTKNFLIQPQLENKPLLGKGFNINKSNLRWEESNNLSCFSNNIDLDPSTEIKQLLNKWRKVAEYPELYISEINLARLEYWQYINSYLHEISSIIHELGKVYCNKTIYHKESLHNLGRGQINNIEFKECIEFSSVFAEANSDSFLP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS06</accession>
    <name>Q5CS06_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626030.1">
        <property type="nucleotide sequence ID" value="XM_626030.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS06"/>
    <dbReference type="GeneID" id="3373142"/>
    <dbReference type="KEGG" id="cpv:cgd5_760"/>
    <dbReference type="InParanoid" id="Q5CS06"/>
    <dbReference type="OrthoDB" id="340143at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="642" mass="74350" checksum="B525A0400577D02A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS15</accession>
    <name>Q5CS15_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_650</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626021.1">
        <property type="nucleotide sequence ID" value="XM_626021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS15"/>
    <dbReference type="GeneID" id="3373308"/>
    <dbReference type="KEGG" id="cpv:cgd5_650"/>
    <dbReference type="InParanoid" id="Q5CS15"/>
    <dbReference type="OMA" id="LPWPIGQ"/>
    <dbReference type="OrthoDB" id="360784at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="663" mass="76526" checksum="326520C8053C1BFD" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS83</accession>
    <name>Q5CS83_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glutamine--fructose-6-phosphate aminotransferase [isomerizing]</fullName>
            <ecNumber evidence="2">2.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_3730</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate</text>
            <dbReference type="Rhea" id="RHEA:13237"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:58725"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="EC" id="2.6.1.16"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628184.1">
        <property type="nucleotide sequence ID" value="XM_628184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS83"/>
    <dbReference type="FunCoup" id="Q5CS83">
        <property type="interactions" value="83"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS83"/>
    <dbReference type="MEROPS" id="C44.A08"/>
    <dbReference type="GeneID" id="3371514"/>
    <dbReference type="KEGG" id="cpv:cgd1_3730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3730"/>
    <dbReference type="InParanoid" id="Q5CS83"/>
    <dbReference type="OMA" id="ASEYRYA"/>
    <dbReference type="OrthoDB" id="15235at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004360">
        <property type="term" value="F:glutamine-fructose-6-phosphate transaminase (isomerizing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006047">
        <property type="term" value="P:UDP-N-acetylglucosamine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00714">
        <property type="entry name" value="GFAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05008">
        <property type="entry name" value="SIS_GlmS_GlmD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05009">
        <property type="entry name" value="SIS_GlmS_GlmD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000006">
        <property type="entry name" value="Glutamine--fructose-6-phosphate aminotransferase [isomerizing]"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000036">
        <property type="entry name" value="Glutamine-fructose-6-phosphate transaminase (Isomerizing), variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017932">
        <property type="entry name" value="GATase_2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005855">
        <property type="entry name" value="GFAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047084">
        <property type="entry name" value="GFAT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035466">
        <property type="entry name" value="GlmS/AgaS_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035490">
        <property type="entry name" value="GlmS/FrlB_SIS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001347">
        <property type="entry name" value="SIS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01135">
        <property type="entry name" value="glmS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001484">
        <property type="entry name" value="PRK00331.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937">
        <property type="entry name" value="GLUCOSAMINE--FRUCTOSE-6-PHOSPHATE AMINOTRANSFERASE, ISOMERIZING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10937:SF0">
        <property type="entry name" value="GLUTAMINE--FRUCTOSE-6-PHOSPHATE TRANSAMINASE (ISOMERIZING)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13522">
        <property type="entry name" value="GATase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01380">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51278">
        <property type="entry name" value="GATASE_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51464">
        <property type="entry name" value="SIS"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 10" id="KW-0032">Aminotransferase</keyword>
    <keyword evidence="7" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glutamine amidotransferase type-2" evidence="8">
        <location>
            <begin position="84"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="9">
        <location>
            <begin position="373"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="SIS" evidence="9">
        <location>
            <begin position="545"/>
            <end position="686"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022576"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="696" mass="76469" checksum="598A0E61446453C7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSA6</accession>
    <name>Q5CSA6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628161.1">
        <property type="nucleotide sequence ID" value="XM_628161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSA6"/>
    <dbReference type="GeneID" id="3371579"/>
    <dbReference type="KEGG" id="cpv:cgd1_3490"/>
    <dbReference type="InParanoid" id="Q5CSA6"/>
    <dbReference type="OMA" id="FANSIQH"/>
    <dbReference type="OrthoDB" id="342020at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="137" mass="15107" checksum="91FC526F729A3235" modified="2005-04-12" version="1">MKTAFQGELNLMNNYYEGPPQQSPRLSALDAGATGFSLNEIFKVATFATSFDHSLFGITNARAAMATSYFIGLGSFIGFIILIALIRIIYFAAKKRNSRSEYTNPNSQRFVVRSSDDIVSNNFGSDKFPAISNRAKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSC2</accession>
    <name>Q5CSC2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cyclin domain protein, possible cyclin H</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_3310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628145.1">
        <property type="nucleotide sequence ID" value="XM_628145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSC2"/>
    <dbReference type="FunCoup" id="Q5CSC2">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSC2"/>
    <dbReference type="GeneID" id="3371454"/>
    <dbReference type="KEGG" id="cpv:cgd1_3310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3310"/>
    <dbReference type="InParanoid" id="Q5CSC2"/>
    <dbReference type="OMA" id="PQIVECA"/>
    <dbReference type="OrthoDB" id="340962at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd20524">
        <property type="entry name" value="CYCLIN_CCNH_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="2">
        <location>
            <begin position="70"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="227" mass="26913" checksum="CB616510ED4BBCAD" modified="2005-04-12" version="1">MSVYPSESHHLKEWVFGSLDLLKTKKNYINEKAKENWKDIFRQISSENFEINELLLTSKDEETLISYYGRQLIEFCNHKQLPFVSKYNASILYHRFFTNQSVMDYDPRIIIFTSISLALKLEEFGLHFTLEKLFGDVPGLNIQEVFRHELTVCNTLKFHLYILNPRNTLEGLRLLYKKYYIDILVVDENLDNNDHKKTENKKNQLISLLSKVILKAETYVLMILHTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSI1</accession>
    <name>Q5CSI1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Transcription factor TAF5p, TBP associated protein involved in transcription</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_2600</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88361.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628086.1">
        <property type="nucleotide sequence ID" value="XM_628086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSI1"/>
    <dbReference type="STRING" id="353152.Q5CSI1"/>
    <dbReference type="GeneID" id="3371690"/>
    <dbReference type="KEGG" id="cpv:cgd1_2600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2600"/>
    <dbReference type="InParanoid" id="Q5CSI1"/>
    <dbReference type="OMA" id="TSECANA"/>
    <dbReference type="OrthoDB" id="10266330at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005669">
        <property type="term" value="C:transcription factor TFIID complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016251">
        <property type="term" value="F:RNA polymerase II general transcription initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08044">
        <property type="entry name" value="TAF5_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.500">
        <property type="entry name" value="TFIID subunit TAF5, NTD2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007582">
        <property type="entry name" value="TFIID_NTD2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037264">
        <property type="entry name" value="TFIID_NTD2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879:SF7">
        <property type="entry name" value="PROTEASOMAL ATPASE-ASSOCIATED FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19879">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR TFIID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04494">
        <property type="entry name" value="TFIID_NTD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160897">
        <property type="entry name" value="Taf5 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="TFIID subunit TAF5 NTD2" evidence="6">
        <location>
            <begin position="125"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="560"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88361.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="753" mass="86145" checksum="3D98416B2A5965DE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSQ0</accession>
    <name>Q5CSQ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative Rab5-interacting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_1770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628017.1">
        <property type="nucleotide sequence ID" value="XM_628017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSQ0"/>
    <dbReference type="GeneID" id="3371359"/>
    <dbReference type="KEGG" id="cpv:cgd1_1770"/>
    <dbReference type="InParanoid" id="Q5CSQ0"/>
    <dbReference type="OMA" id="WILQICA"/>
    <dbReference type="OrthoDB" id="286395at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029008">
        <property type="entry name" value="EMC6-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07019">
        <property type="entry name" value="EMC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="70"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="95" mass="10566" checksum="8B1F1B0674CEB7A9" modified="2005-04-12" version="1" fragment="single">TRKSNFQDEVSLITYWILQICALLFGVGCGIFGLKGATVLISAILGLVFIGTTYLNLLDIPERILDPTEIVIENVATCLVTFILTWTTMYTLIHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSS0</accession>
    <name>Q5CSS0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription factor E2F</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="EAK88436.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_627997.1"/>
    </dbReference>
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    <dbReference type="STRING" id="353152.Q5CSS0"/>
    <dbReference type="GeneID" id="3371609"/>
    <dbReference type="KEGG" id="cpv:cgd1_1570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1570"/>
    <dbReference type="InParanoid" id="Q5CSS0"/>
    <dbReference type="OMA" id="ECGPMEM"/>
    <dbReference type="OrthoDB" id="344073at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="11"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="174"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="214"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88436.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="582" mass="70667" checksum="9AF8ED446EDECDD0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSS5</accession>
    <name>Q5CSS5_CRYPI</name>
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        <submittedName>
            <fullName evidence="4">Extracellular membrane associated protein with a signal peptide, EGF domain, 9x transmembrane domains and a pentraxin domain</fullName>
        </submittedName>
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        <name evidence="4" type="ORF">cgd1_1520</name>
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        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
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        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
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                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="nucleotide sequence ID" value="XM_627992.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSS5"/>
    <dbReference type="GeneID" id="3371613"/>
    <dbReference type="KEGG" id="cpv:cgd1_1520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1520"/>
    <dbReference type="InParanoid" id="Q5CSS5"/>
    <dbReference type="OMA" id="IASENTC"/>
    <dbReference type="OrthoDB" id="340489at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00185">
        <property type="entry name" value="TNFRSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011641">
        <property type="entry name" value="Tyr-kin_ephrin_A/B_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264:SF3">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07699">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01411">
        <property type="entry name" value="Ephrin_rec_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
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        <location>
            <begin position="9"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="260"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="323"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
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        </location>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="433"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="526"/>
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    <feature type="transmembrane region" description="Helical" evidence="2">
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            <end position="584"/>
        </location>
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        <location>
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            <end position="624"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="738"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine-protein kinase ephrin type A/B receptor-like" evidence="3">
        <location>
            <begin position="75"/>
            <end position="118"/>
        </location>
    </feature>
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            <begin position="1320"/>
            <end position="1353"/>
        </location>
    </feature>
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        </location>
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            <end position="2247"/>
        </location>
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        </location>
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            <begin position="2983"/>
            <end position="3008"/>
        </location>
    </feature>
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            <begin position="1324"/>
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        </location>
    </feature>
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        <location>
            <begin position="1734"/>
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        </location>
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        <location>
            <begin position="1803"/>
            <end position="1814"/>
        </location>
    </feature>
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        <location>
            <begin position="2983"/>
            <end position="2998"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF07699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="3008" mass="343678" checksum="F09C5C3ED972011C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSS7</accession>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="KEGG" id="cpv:cgd1_1500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1500"/>
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    <dbReference type="OrthoDB" id="340434at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
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    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="21"/>
            <end position="43"/>
        </location>
    </feature>
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            <begin position="59"/>
            <end position="76"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAK88443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="245" mass="28052" checksum="6E7738AF2A4CA75A" modified="2005-04-12" version="1">MEGGENKNHVGMNCSLDDLIRKEAPKRPNVNKSIKKNTSRGKPVMKNKKMVRSERTFISKRNNGSAQVSSGRNNASGLYRGTYKKEGKSQSLYMRRKKDFQMRTELNKNDNIPDKYCELSNLDERERIIKMIRLEHKDEDFTLQVLLDSNPIIIVNKITGVIKLNSFNCRTSSMLDVWNLLLKPLGLSLQVVNMGSDCTNWSITDGSCYMENFKDGMIVRGSGSRDTARNARFSILEQHIRQLII</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2026-01-28" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
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    <gene>
        <name evidence="4" type="primary">SKSR1</name>
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        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
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            <taxon>Sar</taxon>
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            <taxon>Coccidia</taxon>
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    <reference key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Iowa II</strain>
        </source>
    </reference>
    <reference key="2">
        <citation type="journal article" date="2025" name="Nat. Commun." volume="16" first="4694" last="4694">
            <title>SKSR1 identified as key virulence factor in Cryptosporidium by genetic crossing.</title>
            <authorList>
                <person name="He W."/>
                <person name="Sun L."/>
                <person name="Hou T."/>
                <person name="Yang Z."/>
                <person name="Yang F."/>
                <person name="Zhang S."/>
                <person name="Wang T."/>
                <person name="Wang X."/>
                <person name="Li N."/>
                <person name="Guo Y."/>
                <person name="Sibley L.D."/>
                <person name="Feng Y."/>
                <person name="Xiao L."/>
            </authorList>
            <dbReference type="PubMed" id="40394032"/>
            <dbReference type="DOI" id="10.1038/s41467-025-60088-7"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>TISSUE SPECIFICITY</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <scope>DISRUPTION PHENOTYPE</scope>
    </reference>
    <comment type="function">
        <text evidence="3">Virulence factor secreted into the parasite-host interface during the late phase of the invasion process. Whether SKSR1 acts as a virulence factor by regulating host cellular responses requires future studies.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Vesicle</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Secreted</location>
        </subcellularLocation>
        <text evidence="3">Localizes in small vesicles near the nucleus (PubMed:40394032). Translocates to the parasite-host interface during invasion (PubMed:40394032).</text>
    </comment>
    <comment type="tissue specificity">
        <text evidence="3">Expressed in sporozoites as well as at most time points of the asexual development.</text>
    </comment>
    <comment type="disruption phenotype">
        <text evidence="3">Significantly reduces growth in vitro, and attenuates parasite virulence in vivo (PubMed:40394032). Reduces infection intensity and abolishes weight loss and mortality in infected mice (PubMed:40394032).</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627876.1">
        <property type="nucleotide sequence ID" value="XM_627876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT41"/>
    <dbReference type="STRING" id="353152.Q5CT41"/>
    <dbReference type="EnsemblProtists" id="EAK88534">
        <property type="protein sequence ID" value="EAK88534"/>
        <property type="gene ID" value="cgd1_140"/>
    </dbReference>
    <dbReference type="GeneID" id="3371434"/>
    <dbReference type="KEGG" id="cpv:cgd1_140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_140"/>
    <dbReference type="InParanoid" id="Q5CT41"/>
    <dbReference type="OMA" id="CQQNNIS"/>
    <dbReference type="OrthoDB" id="344251at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032922">
        <property type="entry name" value="SON"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46528:SF1">
        <property type="entry name" value="PROTEIN SON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at transcript level"/>
    <keyword id="KW-0325">Glycoprotein</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0964">Secreted</keyword>
    <keyword id="KW-0732">Signal</keyword>
    <keyword id="KW-0843">Virulence</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254221" description="Virulence factor SKSR1">
        <location>
            <begin position="25"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="139"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="257"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="267"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="275"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="303"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="733"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="868"/>
        </location>
    </feature>
    <feature type="glycosylation site" description="N-linked (GlcNAc...) asparagine" evidence="2">
        <location>
            <position position="957"/>
        </location>
    </feature>
    <evidence type="ECO:0000255" key="1"/>
    <evidence type="ECO:0000255" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="3">
        <source>
            <dbReference type="PubMed" id="40394032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="4">
        <source>
            <dbReference type="PubMed" id="40394032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="963" mass="110972" checksum="DAE0C8EB50C08C8F" modified="2005-04-12" version="1" precursor="true"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT55</accession>
    <name>Q5CT55_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_4370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626614.1">
        <property type="nucleotide sequence ID" value="XM_626614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT55"/>
    <dbReference type="GeneID" id="3373706"/>
    <dbReference type="KEGG" id="cpv:cgd2_4370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4370"/>
    <dbReference type="InParanoid" id="Q5CT55"/>
    <dbReference type="OrthoDB" id="344237at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="217"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="374" mass="43104" checksum="4EFF0426EB51C9CA" modified="2005-04-12" version="1">MVYLFVLAIALLYTNTNYIINNRISTQLSLLTIQLSSSSSRHDSIVLSELTLEQSYRSCLDDLQILKQSLAASIEEFEACKAVEAELESSYHRKSSVCRLLEEDYNKYCKSHNFKPPALEKDLCRTLLERIKECLEQKRKLGGNLNKKTRECQELKKEINARTEMYNKLDKKCSKIEQQLFNERSQAGIHVVDSESIMDKPTSSLCSADIPLLLEVITKTEIKLEVCMEQLTELSERLAEKTNEMYEISEQITTALGGAISKKGLLGKKKSKSAEIKSLESALKLLEEQKMGLKKFQLAKENECRNLQTKLDQAKERLQIAELQSTTSEGRTGRRGYFSRFTGFVSRTYRRLTSRLTSRFTRNNSRRRRRESRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTC8</accession>
    <name>Q5CTC8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">4x PHD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_3540</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88674.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626541.1">
        <property type="nucleotide sequence ID" value="XM_626541.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTC8"/>
    <dbReference type="GeneID" id="3373752"/>
    <dbReference type="KEGG" id="cpv:cgd2_3540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3540"/>
    <dbReference type="InParanoid" id="Q5CTC8"/>
    <dbReference type="OMA" id="YINCILA"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd15571">
        <property type="entry name" value="ePHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034732">
        <property type="entry name" value="EPHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF164">
        <property type="entry name" value="ALHAMBRA, ISOFORM P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51805">
        <property type="entry name" value="EPHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="571"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="969"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="7">
        <location>
            <begin position="1575"/>
            <end position="1679"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="2136"/>
            <end position="2194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="736"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1744"/>
            <end position="1779"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1906"/>
            <end position="1946"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2259"/>
            <end position="2295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2320"/>
            <end position="2350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2391"/>
            <end position="2445"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="741"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1911"/>
            <end position="1945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2259"/>
            <end position="2286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2322"/>
            <end position="2350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2395"/>
            <end position="2417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="2424"/>
            <end position="2445"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51805"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88674.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2445" mass="277816" checksum="FCC4DA970073D674" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTI6</accession>
    <name>Q5CTI6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_2850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626483.1">
        <property type="nucleotide sequence ID" value="XM_626483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTI6"/>
    <dbReference type="GeneID" id="3373467"/>
    <dbReference type="KEGG" id="cpv:cgd2_2850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2850"/>
    <dbReference type="InParanoid" id="Q5CTI6"/>
    <dbReference type="OMA" id="NLLIINC"/>
    <dbReference type="OrthoDB" id="336387at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254506" evidence="1">
        <location>
            <begin position="18"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="184" mass="20955" checksum="C326F09692768AE0" modified="2005-04-12" version="1">MKNNLFLIFILIGSVFTSIIKCSKKDIIAARSSTRKISDELNDLLASKAYFLVDPNYFWSLDATTQVETKAPLSESEFLVVNAPSIGIEELIFIKNRKKDGEIFYSHESNSFLTYTLECINIGKTGGWVLKQPSSEIAYGFAINNGNEESENCKRALMPYKLEKWYNSLNQQIKDMLVTQIWIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTM0</accession>
    <name>Q5CTM0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_2470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626449.1">
        <property type="nucleotide sequence ID" value="XM_626449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTM0"/>
    <dbReference type="STRING" id="353152.Q5CTM0"/>
    <dbReference type="GeneID" id="3373497"/>
    <dbReference type="KEGG" id="cpv:cgd2_2470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2470"/>
    <dbReference type="InParanoid" id="Q5CTM0"/>
    <dbReference type="OMA" id="TIEYKSA"/>
    <dbReference type="OrthoDB" id="342617at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="26"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="234" mass="27400" checksum="1CF6708F27A2D9D6" modified="2005-04-12" version="1">MFKKINIFLKNETFIFNGSIIGYQEILFIILITTVLVYFGIISVLYDAEILQNVIDEATEIHNRESINNINSLNNISAQRLVCKFISSFNKIVYDANELSSSQKFNERLLKLLSESFPSNSIDISYQFLFLIYRKILISKTKYLVISHLQDFSEVMLHRLKIPKHTLVMCYSEIIKLDDSILSKEEKNHFMHEKERLQIIMNIERDVVLQNIKLNILRVAKKIKFAIEVAIFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU06</accession>
    <name>Q5CU06_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CpCCp3, multidomain extracellular protein with a signal peptide and the following architecture: LH2+LCCL+2xSR+LCCL+pentraxin+2xLCCL</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88868.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626313.1">
        <property type="nucleotide sequence ID" value="XM_626313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU06"/>
    <dbReference type="SMR" id="Q5CU06"/>
    <dbReference type="FunCoup" id="Q5CU06">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU06"/>
    <dbReference type="GeneID" id="3373372"/>
    <dbReference type="KEGG" id="cpv:cgd2_790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_790"/>
    <dbReference type="InParanoid" id="Q5CU06"/>
    <dbReference type="OMA" id="AGENLCG"/>
    <dbReference type="OrthoDB" id="536948at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02899">
        <property type="entry name" value="PLAT_SR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.60.20">
        <property type="entry name" value="PLAT/LH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.250.10">
        <property type="entry name" value="SRCR-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001024">
        <property type="entry name" value="PLAT/LH2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036392">
        <property type="entry name" value="PLAT/LH2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017229">
        <property type="entry name" value="Scavenger_rcpt_PxSR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001190">
        <property type="entry name" value="SRCR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036772">
        <property type="entry name" value="SRCR-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13385">
        <property type="entry name" value="Laminin_G_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01477">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00530">
        <property type="entry name" value="SRCR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037512">
        <property type="entry name" value="PxSR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00202">
        <property type="entry name" value="SR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49723">
        <property type="entry name" value="Lipase/lipooxygenase domain (PLAT/LH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56487">
        <property type="entry name" value="SRCR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50095">
        <property type="entry name" value="PLAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50287">
        <property type="entry name" value="SRCR_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLAT" evidence="3">
        <location>
            <begin position="180"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="5">
        <location>
            <begin position="296"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="416"/>
            <end position="526"/>
        </location>
    </feature>
    <feature type="domain" description="SRCR" evidence="4">
        <location>
            <begin position="538"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="5">
        <location>
            <begin position="691"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="5">
        <location>
            <begin position="1039"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="5">
        <location>
            <begin position="1145"/>
            <end position="1244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88868.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1247" mass="134533" checksum="7B0B82466FF9F1D5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU51</accession>
    <name>Q5CU51_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Secreted insulinase like peptidase, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd3_4200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626963.1">
        <property type="nucleotide sequence ID" value="XM_626963.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU51"/>
    <dbReference type="GeneID" id="3373887"/>
    <dbReference type="KEGG" id="cpv:cgd3_4200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4200"/>
    <dbReference type="InParanoid" id="Q5CU51"/>
    <dbReference type="OMA" id="MRASDIT"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="7">
        <location>
            <begin position="177"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="8">
        <location>
            <begin position="339"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1286" mass="148679" checksum="ED406A54FD91868F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU55</accession>
    <name>Q5CU55_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_4160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626959.1">
        <property type="nucleotide sequence ID" value="XM_626959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU55"/>
    <dbReference type="STRING" id="353152.Q5CU55"/>
    <dbReference type="GeneID" id="3373891"/>
    <dbReference type="KEGG" id="cpv:cgd3_4160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4160"/>
    <dbReference type="InParanoid" id="Q5CU55"/>
    <dbReference type="OMA" id="YICSSTH"/>
    <dbReference type="OrthoDB" id="341198at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042246">
        <property type="entry name" value="ZCCHC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242:SF1">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46242">
        <property type="entry name" value="ZINC FINGER CCHC DOMAIN-CONTAINING PROTEIN 9 ZCCHC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00098">
        <property type="entry name" value="zf-CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="domain" description="CCHC-type" evidence="3">
        <location>
            <begin position="252"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="7"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="78"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="330" mass="37522" checksum="9BD0679760C89C02" modified="2005-04-12" version="1">MSKIKTNIKEKSEKKKEKRSKEVEKNSKKKVSEILNEPVNIEKTLEKKKKSKSKQLDENHEEKNICSDKQAKEEDLKVKKKSKGSKKAKKIKSGCWTTDMINESIQNLESMLNDESGKLSKSKKRRIIMRLSKLKKGLRGEVEIGGQIQKSIKTIKREMKQKSMNSSISLRKNSNVVCLCCRKKGHQMSDCRYYKQTNEEAENGDNEINSISERNASGKEVFKCFLCGELGHTLKDCKKPRNDNSVLPFASCFRCGKTGHIVAFCPNNETGSIYPRGGSCNICGSVKHLARNCDQQISKTNKNKKSIEGKNKEKMNIGMDDPDLMWNEAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU68</accession>
    <name>Q5CU68_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">eIF-3 p25/subunit 11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_4020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626946.1">
        <property type="nucleotide sequence ID" value="XM_626946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU68"/>
    <dbReference type="FunCoup" id="Q5CU68">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU68"/>
    <dbReference type="GeneID" id="3373923"/>
    <dbReference type="KEGG" id="cpv:cgd3_4020"/>
    <dbReference type="InParanoid" id="Q5CU68"/>
    <dbReference type="OMA" id="GDDLCAD"/>
    <dbReference type="OrthoDB" id="337745at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006446">
        <property type="term" value="P:regulation of translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.250">
        <property type="entry name" value="ARM repeat, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03010">
        <property type="entry name" value="eIF3k"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033464">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009374">
        <property type="entry name" value="eIF3k"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016020">
        <property type="entry name" value="Transl_init_fac_sub12_N_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13022:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10075">
        <property type="entry name" value="CSN8_PSD8_EIF3K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSN8/PSMD8/EIF3K" evidence="1">
        <location>
            <begin position="92"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10075"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="262" mass="29988" checksum="19E105999A8023A0" modified="2005-04-12" version="1" fragment="single">NFGFCLNLGIIQIYKKSVIDQDEELILNLFLLKMAQVDQKITSLLNSASRYDVSNLDIFENCVRDQIIKGQYSILNNLVVLLQYSIYPKRTNLEIVQDILLLSIIRGPLSSDFLSCTYQIPLSVQNDPNIKQIIQLNDLLTSCRYANMWNLLKTNDQLRSKVEKIQGFYDSIRDIIIYSVNCSHSCISTAVLSELLDFPKDSTELKNIIEKNKWILDSACEIIRIPLPENPIENVDSNANKNKSLGCNEVIFKNYLNLLSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU80</accession>
    <name>Q5CU80_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Snu114p GTpase, U5 snRNP-specific protein, 116 kDa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd3_3880</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626934.1">
        <property type="nucleotide sequence ID" value="XM_626934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU80"/>
    <dbReference type="FunCoup" id="Q5CU80">
        <property type="interactions" value="565"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU80"/>
    <dbReference type="GeneID" id="3373849"/>
    <dbReference type="KEGG" id="cpv:cgd3_3880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3880"/>
    <dbReference type="InParanoid" id="Q5CU80"/>
    <dbReference type="OMA" id="YIFRPIR"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04098">
        <property type="entry name" value="eEF2_C_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04090">
        <property type="entry name" value="EF2_II_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01683">
        <property type="entry name" value="EF2_IV_snRNP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04167">
        <property type="entry name" value="Snu114p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.240:FF:000004">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000029">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000009">
        <property type="entry name" value="116 kDa U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000646">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031950">
        <property type="entry name" value="EFTUD2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031157">
        <property type="entry name" value="G_TR_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044121">
        <property type="entry name" value="Snu114_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005517">
        <property type="entry name" value="Transl_elong_EFG/EF2_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035655">
        <property type="entry name" value="U5-116kDa_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF6">
        <property type="entry name" value="116 KDA U5 SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03764">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16004">
        <property type="entry name" value="EFTUD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00889">
        <property type="entry name" value="EFG_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00301">
        <property type="entry name" value="G_TR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="10">
        <location>
            <begin position="173"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="13"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1035" mass="117822" checksum="9156E840B55EB7E4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU84</accession>
    <name>Q5CU84_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">PUB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_3830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626930.1">
        <property type="nucleotide sequence ID" value="XM_626930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU84"/>
    <dbReference type="GeneID" id="3373850"/>
    <dbReference type="KEGG" id="cpv:cgd3_3830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3830"/>
    <dbReference type="InParanoid" id="Q5CU84"/>
    <dbReference type="OMA" id="KNTHCKE"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd09212">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PUB" evidence="2">
        <location>
            <begin position="491"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF09409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="592" mass="68692" checksum="D6E5123D7025AE9B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU94</accession>
    <name>Q5CU94_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_3720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626920.1">
        <property type="nucleotide sequence ID" value="XM_626920.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU94"/>
    <dbReference type="GeneID" id="3373856"/>
    <dbReference type="KEGG" id="cpv:cgd3_3720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3720"/>
    <dbReference type="InParanoid" id="Q5CU94"/>
    <dbReference type="OrthoDB" id="121932at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="106" mass="11905" checksum="6F6DD34E269FF59B" modified="2005-04-12" version="1">MNESIGELTTIPIIYSKQHKERLVLLEFQGSLSISKLNTETGEMINSENNDDFNDTVIGQLINFDKISQSLNNPEIVNPLESAIQYSKNNPIELKVGYHKLIGKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU95</accession>
    <name>Q5CU95_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_3710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88975.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626919.1">
        <property type="nucleotide sequence ID" value="XM_626919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU95"/>
    <dbReference type="GeneID" id="3373854"/>
    <dbReference type="KEGG" id="cpv:cgd3_3710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3710"/>
    <dbReference type="InParanoid" id="Q5CU95"/>
    <dbReference type="OMA" id="FVEYRII"/>
    <dbReference type="OrthoDB" id="339477at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="523"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="387"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="523"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88975.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="546" mass="61232" checksum="DEAC2543AF01E8CA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUA2</accession>
    <name>Q5CUA2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_3630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88982.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626912.1">
        <property type="nucleotide sequence ID" value="XM_626912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUA2"/>
    <dbReference type="GeneID" id="3373861"/>
    <dbReference type="KEGG" id="cpv:cgd3_3630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3630"/>
    <dbReference type="InParanoid" id="Q5CUA2"/>
    <dbReference type="OMA" id="TMESYNI"/>
    <dbReference type="OrthoDB" id="344032at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="345"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="468"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88982.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="490" mass="57727" checksum="10B1A74DF264F87A" modified="2005-04-12" version="1">MSRKHSILNNTKIIMNLFSFLEISDLVKMRNLNSCCKLISDHYIKMSIHRDKSKYKNIEIENNDESNSSNNNNMNNIANYFCPSKINNNNNISQLRMKFLQLWNIYSNKNLIEKVNYYDYNLCFIIKILIYLISNVKDGLDLSLIFATNNFYLQQIYGYGLDDSNSLSSNINNHSKNSHIFNIERDLDIDIEQDEYIDFQSNSSTIGLNHNHESIPIYIQEFFRNEGIWKVIAKLSGYNLSNAELSSESNGIFEYYLWPEKMEDPKYSIIDQNIIENIFSTILKMKTLDPNIRKQVTILMNKNLKAELTFYSNTGNIINRSNINIVKDQFNPSYYSSIDNNNNNNHHHHHHHHNCNTDFQRDNSHNINSNYPSEMIYSLLQPCTFINSQLSSIILLWIINFLKLQKQLPCLKQIPKNDKFLFNANNNNNNKYRLQHRNHQFLHNHNYNYNKIPLNSKFSSTSRFSKLNNINNQNQRSNPKSKPKPKSKPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUF2</accession>
    <name>Q5CUF2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">WD40 repeat-containing protein SMU1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_3070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus speckle</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the WD repeat SMU1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626862.1">
        <property type="nucleotide sequence ID" value="XM_626862.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUF2"/>
    <dbReference type="STRING" id="353152.Q5CUF2"/>
    <dbReference type="GeneID" id="3374091"/>
    <dbReference type="KEGG" id="cpv:cgd3_3070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3070"/>
    <dbReference type="InParanoid" id="Q5CUF2"/>
    <dbReference type="OMA" id="MMKQQEP"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045184">
        <property type="entry name" value="SMU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254970" description="WD40 repeat-containing protein SMU1" evidence="9">
        <location>
            <begin position="28"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="399"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="595" mass="67886" checksum="9A78F2ECD09B5A1F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUF5</accession>
    <name>Q5CUF5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit delta</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit delta</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_3020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eIF-2B alpha/beta/delta subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89031.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626859.1">
        <property type="nucleotide sequence ID" value="XM_626859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUF5"/>
    <dbReference type="STRING" id="353152.Q5CUF5"/>
    <dbReference type="GeneID" id="3374095"/>
    <dbReference type="KEGG" id="cpv:cgd3_3020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3020"/>
    <dbReference type="InParanoid" id="Q5CUF5"/>
    <dbReference type="OMA" id="YAEGIIC"/>
    <dbReference type="OrthoDB" id="10254737at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10470">
        <property type="entry name" value="Translation initiation factor eif-2b, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000649">
        <property type="entry name" value="IF-2B-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042529">
        <property type="entry name" value="IF_2B-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037171">
        <property type="entry name" value="NagB/RpiA_transferase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10233:SF14">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT DELTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01008">
        <property type="entry name" value="IF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100950">
        <property type="entry name" value="NagB/RpiA/CoA transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044356"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89031.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="357" mass="40480" checksum="EEE8788F56EC5C58" modified="2005-04-12" version="1">MEKKNVVQNIFNCPICPYFGRNSISHSFISILDQSKIHPAILRLGMRMKDRKIVGTNMRSKCLLIAIGQMLEDYYCPPYKSIEKHLKMVLDVHISYITSQRQHNIAMGNVIKWLKKQICKINPSLPPNEIINQLISSIKTYIYQRIVNACERISYLVSNKYITDGDVIVTYSNSSSVIKSLFKAAEMNKNFQLIVVDSKNNLDSSSQDIAKKLSLKGIKITYTLLNCLAYHLRYATKVIIGSCAIFSNGYVMNRSGSSLVAMLANIHHIPVMIVSESYKLCEKNYFEYSTVFNEVVEQGISDNLQYVPENSESLPKPQIATFIPCYDVIPPKFINAIVTEDGIFSAESFSIQNKPIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUH1</accession>
    <name>Q5CUH1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_2850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626843.1">
        <property type="nucleotide sequence ID" value="XM_626843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUH1"/>
    <dbReference type="GeneID" id="3374107"/>
    <dbReference type="KEGG" id="cpv:cgd3_2850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2850"/>
    <dbReference type="InParanoid" id="Q5CUH1"/>
    <dbReference type="OMA" id="NENTCLF"/>
    <dbReference type="OrthoDB" id="339072at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="369" mass="41500" checksum="0D8F8F92B4F4EF4F" modified="2005-04-12" version="1">MSGFNIEKLINLNSFSQGISENETLALSLPTGNTVDLDFESYCYYYSDNTYNNEDISSILNKKNEINGINNWVNFNSVENTKYFEECIPSNINTNINGMNHVNDAEYTCHDYYNKDNFLPSLINSNFVTNYFHNSEVKVKSKVKSIVLFLRANLGINVAKNFKEEVEALGAYVFIADNCKELLDVNNELDGCKRLIVTSADVALNERLAEEISKKKLSNFLGVVLYCGPHAEYHIKWCSKVSSIKFLSQNLIEVRRAISWLFSESLLNANEMPNIGRRGKKVALQDLKRSSQSKINSVASSFPSLGMQTIGTQSISEEDRNIHSTGSYSPFGINNGNPHDNIASMFRTLALETKIATQVNNGQFFSIDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUH4</accession>
    <name>Q5CUH4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_2820</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626840.1">
        <property type="nucleotide sequence ID" value="XM_626840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUH4"/>
    <dbReference type="FunCoup" id="Q5CUH4">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUH4"/>
    <dbReference type="GeneID" id="3373958"/>
    <dbReference type="KEGG" id="cpv:cgd3_2820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2820"/>
    <dbReference type="InParanoid" id="Q5CUH4"/>
    <dbReference type="OMA" id="RRTMSHN"/>
    <dbReference type="OrthoDB" id="442863at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000172">
        <property type="term" value="C:ribonuclease MRP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001682">
        <property type="term" value="P:tRNA 5'-leader removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029043">
        <property type="entry name" value="GcvT/YgfZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039182">
        <property type="entry name" value="Pop1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055079">
        <property type="entry name" value="POP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009723">
        <property type="entry name" value="Pop1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012590">
        <property type="entry name" value="POPLD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731">
        <property type="entry name" value="RIBONUCLEASES P/MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22731:SF3">
        <property type="entry name" value="RIBONUCLEASES P_MRP PROTEIN SUBUNIT POP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22770">
        <property type="entry name" value="POP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06978">
        <property type="entry name" value="POP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08170">
        <property type="entry name" value="POPLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101790">
        <property type="entry name" value="Aminomethyltransferase beta-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pop1 N-terminal" evidence="4">
        <location>
            <begin position="32"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="POPLD" evidence="5">
        <location>
            <begin position="503"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="POP1 C-terminal" evidence="6">
        <location>
            <begin position="751"/>
            <end position="799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06978"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF22770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="823" mass="97434" checksum="49204F1248D94852" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUL8</accession>
    <name>Q5CUL8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible domain AAA, ATpase family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626796.1">
        <property type="nucleotide sequence ID" value="XM_626796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUL8"/>
    <dbReference type="GeneID" id="3374033"/>
    <dbReference type="KEGG" id="cpv:cgd3_2290"/>
    <dbReference type="InParanoid" id="Q5CUL8"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ATPase AAA-type core" evidence="1">
        <location>
            <begin position="13"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="130" mass="15408" checksum="4CAF108C96900F2B" modified="2005-04-12" version="1">MPVFNLTNIYHRLGKSFLVSSIADSLNYSIKYVHTADIFNATIGFFERYLKEIIDVCTRKRKYILVIEDIDQYLLEENNTLLSLMFFFDIISRSNKWMHSEIMIFGTSTSKNIVCTRMFQVCCFLRGFIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUT3</accession>
    <name>Q5CUT3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Glucosidase II subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd3_1580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycan metabolism; N-glycan metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89133.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626731.1">
        <property type="nucleotide sequence ID" value="XM_626731.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUT3"/>
    <dbReference type="GeneID" id="3374023"/>
    <dbReference type="KEGG" id="cpv:cgd3_1580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1580"/>
    <dbReference type="InParanoid" id="Q5CUT3"/>
    <dbReference type="OMA" id="HEEDIWE"/>
    <dbReference type="OrthoDB" id="440381at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14752">
        <property type="entry name" value="GH31_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011013">
        <property type="entry name" value="Gal_mutarotase_sf_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030458">
        <property type="entry name" value="Glyco_hydro_31_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74650">
        <property type="entry name" value="Galactose mutarotase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00129">
        <property type="entry name" value="GLYCOSYL_HYDROL_F31_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="11">
        <location>
            <begin position="174"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="10">
        <location>
            <begin position="490"/>
            <end position="918"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042895"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89133.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1387" mass="161232" checksum="7517075F03885297" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUT9</accession>
    <name>Q5CUT9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626725.1">
        <property type="nucleotide sequence ID" value="XM_626725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUT9"/>
    <dbReference type="GeneID" id="3374019"/>
    <dbReference type="KEGG" id="cpv:cgd3_1500"/>
    <dbReference type="InParanoid" id="Q5CUT9"/>
    <dbReference type="OMA" id="KTRINTC"/>
    <dbReference type="OrthoDB" id="344021at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="298"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="305"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="325" mass="37937" checksum="C51F7AF769BB6310" modified="2005-04-12" version="1">METMSREYEQLKNSILELANGISNISENKNLPILLNILMDGIGAYNSMISRQSNFTDSMLEMSFWSIELMDTIYATNGGMTTLLDYTLEKIQDQFPSILNTFDEINYLDKFSTRYKISEIYRGLVRLNFGLDQRIKSLEEMINKRQKSRNKSKAWELYNREEVLLKINNLRELSDFLKYEFISLIKDILFFSKYLGIDDEHNSAINSSHETDTDSIKGSYDDLISEIETVCEIFQNGQVHKTREIMDRIISNLDVEEFEEILGAFNLLNWLKGRVSICLGRNLENNIEEISAICSNKQQESSSSDLDKDDERLLNHQETRYYDED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUZ0</accession>
    <name>Q5CUZ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626674.1">
        <property type="nucleotide sequence ID" value="XM_626674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUZ0"/>
    <dbReference type="GeneID" id="3374177"/>
    <dbReference type="KEGG" id="cpv:cgd3_940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_940"/>
    <dbReference type="InParanoid" id="Q5CUZ0"/>
    <dbReference type="OMA" id="YWIEITF"/>
    <dbReference type="OrthoDB" id="341771at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="208" mass="24118" checksum="ECC2B9B4B51B3F34" modified="2005-04-12" version="1">MHENNENDLSLFKLKKLPQFPRLTSLNLNISLEKHSEECEKPEYKESHPKCKKKKPRDTLPQNVNNENTIIFQLGSSISKKKCVDVLKKKEIVTEKNHYSPKNDNIEETNNTQQKTKEELLQIGKNHSIESIQNIYQKILMVSIEMNESRESSSKEISNMITEINQIKESLVDYWIELTLTQAKSMNNNLESNSDADTVLNQALTKQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV22</accession>
    <name>Q5CV22_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal peptide containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626642.1">
        <property type="nucleotide sequence ID" value="XM_626642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV22"/>
    <dbReference type="GeneID" id="3373793"/>
    <dbReference type="KEGG" id="cpv:cgd3_570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_570"/>
    <dbReference type="InParanoid" id="Q5CV22"/>
    <dbReference type="OMA" id="WESSLPM"/>
    <dbReference type="OrthoDB" id="342965at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254434" description="Signal peptide containing protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="423"/>
            <end position="447"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="447" mass="51612" checksum="515E59344ED64FDE" modified="2005-04-12" version="1">MFELKFLFLFLALALLRNAAGDEFSDYSIFQSPESSTELSGGSLGMLNFGQKQSLEDTTFDTQSQVLLDHFQDPNEPSTIGNMISENNYPVERKEIIGSFDDKYKESPYSETSMSSRRGKRSQNIFSINKILSKYSKEELALLNEYLISFSMLLKRRFRKFIFKKYSPSRIRSQFAKMYVDKFGGSKSKALLKLREFEKILSLKHSAARRLFHSQFNLLISTLNSAEALIYLTEKWRYQPTYISEPLLVVSKSSYNKLMNLCKKKSRKTKIVLVSASSELIPKKFRKSDLNDSFQELSKFSKTIHSFQESASSGGADSKLSLGTTQCNWDSSRKKKAKFTKSSLKCFFKPKKRSFFHIHYYDITNTAKFKYLMQVLLRYKPNPYSQNAYPLIIIPVLIGIPQIDKNGSILGLNSITEVTKKKRKYGKSFNHRNKKKSNKKKRTKLGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV34</accession>
    <name>Q5CV34_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mRNA 5'-phosphatase</fullName>
            <ecNumber evidence="3">3.6.1.74</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_450</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a 5'-end triphospho-ribonucleoside in mRNA + H2O = a 5'-end diphospho-ribonucleoside in mRNA + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:67004"/>
            <dbReference type="Rhea" id="RHEA-COMP:17164"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167618"/>
            <dbReference type="EC" id="3.6.1.74"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:67005"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.74" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626630.1">
        <property type="nucleotide sequence ID" value="XM_626630.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV34"/>
    <dbReference type="GeneID" id="3373806"/>
    <dbReference type="KEGG" id="cpv:cgd3_450"/>
    <dbReference type="InParanoid" id="Q5CV34"/>
    <dbReference type="OMA" id="NSCTINR"/>
    <dbReference type="OrthoDB" id="272147at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140818">
        <property type="term" value="F:mRNA 5'-triphosphate monophosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004651">
        <property type="term" value="F:polynucleotide 5'-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.10">
        <property type="entry name" value="mRNA triphosphatase Cet1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033469">
        <property type="entry name" value="CYTH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004206">
        <property type="entry name" value="mRNA_triPase_Cet1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037009">
        <property type="entry name" value="mRNA_triPase_Cet1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02940">
        <property type="entry name" value="mRNA_triPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55154">
        <property type="entry name" value="CYTH-like phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="mRNA triphosphatase Cet1-like" evidence="5">
        <location>
            <begin position="11"/>
            <end position="191"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00035028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047740"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="331" mass="38096" checksum="6BA0D5C8B49B3B1B" modified="2005-04-12" version="1">MCLLLPSEKEFSYRFSPGLEKWQMTSVVEELRKDFDESKIPYIIKNRNTNDYYVHNPNKSETEDKSLIRLSYISPKNQKDKPTEAIWKEKIAVFDFCSPGQPGDLETKHNIENGTLLKDFRIAINLEHKENPIEVANTVTGPIENSCVLERRRERETVEVSNFVLDSTHVVQIESRRGFRQCETYELELELKPSHFIPLLKSYIEDTNNGKLKVIGTHPFIKLLTNFVNLVFGITLFLNNKKPNEQIESSIQNSSGNENQIMDLTSCTQSNEIVQAFKKYVSPITPILGDYLYRAVASEKQKLNRPQDIICKDDIDISLGIKPLPPDTKEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV54</accession>
    <name>Q5CV54_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_5370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627415.1">
        <property type="nucleotide sequence ID" value="XM_627415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV54"/>
    <dbReference type="GeneID" id="3374217"/>
    <dbReference type="KEGG" id="cpv:cgd8_5370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5370"/>
    <dbReference type="InParanoid" id="Q5CV54"/>
    <dbReference type="OrthoDB" id="344303at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="54"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="104"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="111"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="158" mass="17652" checksum="D31D68C9E314C7E4" modified="2005-04-12" version="1">MLLNKNSSSKSFCFTFLVLFYLCVYLYLYEEKIVVRTYTISLVKLQTLPNVDEIDQRSTGSNPERKHDDGDQTKAEDTTGVVGGTYGPVRCRYPSAPGFQILSVVDMGPTKNKEGNGNEGHRLRNRHKRGSGKNRKRNSSGLKPHTDSGNDADCESTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVD1</accession>
    <name>Q5CVD1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Large protein with possible domain of nucleoporin, Non-repetitive/WGA-negative nucleoporin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_4520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89588.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627338.1">
        <property type="nucleotide sequence ID" value="XM_627338.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVD1"/>
    <dbReference type="GeneID" id="3374543"/>
    <dbReference type="KEGG" id="cpv:cgd8_4520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4520"/>
    <dbReference type="InParanoid" id="Q5CVD1"/>
    <dbReference type="OMA" id="SHITACC"/>
    <dbReference type="OrthoDB" id="339701at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89588.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2222" mass="257505" checksum="D9CF2618659B788F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVD3</accession>
    <name>Q5CVD3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">1-phosphatidylinositol 4-kinase</fullName>
            <ecNumber evidence="2">2.7.1.67</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_4500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19877"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57880"/>
            <dbReference type="ChEBI" id="CHEBI:58178"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.67"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.67" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627336.1">
        <property type="nucleotide sequence ID" value="XM_627336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVD3"/>
    <dbReference type="SMR" id="Q5CVD3"/>
    <dbReference type="FunCoup" id="Q5CVD3">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVD3"/>
    <dbReference type="BindingDB" id="Q5CVD3"/>
    <dbReference type="GeneID" id="3374540"/>
    <dbReference type="KEGG" id="cpv:cgd8_4500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4500"/>
    <dbReference type="InParanoid" id="Q5CVD3"/>
    <dbReference type="OMA" id="YEESFAY"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004430">
        <property type="term" value="F:1-phosphatidylinositol 4-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05168">
        <property type="entry name" value="PI4Kc_III_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1070.11:FF:000016">
        <property type="entry name" value="PIK1p Phosphatidylinositol 4-kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001263">
        <property type="entry name" value="PI3K_accessory_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057754">
        <property type="entry name" value="PI4-kinase_beta/PIK1_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049160">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048:SF22">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21245">
        <property type="entry name" value="PI4KB-PIK1_PIK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51545">
        <property type="entry name" value="PIK_HELICAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PIK helical" evidence="6">
        <location>
            <begin position="1"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="5">
        <location>
            <begin position="830"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1114" mass="129008" checksum="ABEE3A687BD9E3B8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVE6</accession>
    <name>Q5CVE6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_4350</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627323.1">
        <property type="nucleotide sequence ID" value="XM_627323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVE6"/>
    <dbReference type="FunCoup" id="Q5CVE6">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVE6"/>
    <dbReference type="GeneID" id="3374529"/>
    <dbReference type="KEGG" id="cpv:cgd8_4350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4350"/>
    <dbReference type="InParanoid" id="Q5CVE6"/>
    <dbReference type="OMA" id="IVEPWIA"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01657">
        <property type="entry name" value="Ribosomal_L7_archeal_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1390.20:FF:000004">
        <property type="entry name" value="60S ribosomal protein L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035808">
        <property type="entry name" value="Ribosomal_uL30_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016082">
        <property type="entry name" value="Ribosomal_uL30_ferredoxin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012988">
        <property type="entry name" value="Ribosomal_uL30_N_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00327">
        <property type="entry name" value="Ribosomal_L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08079">
        <property type="entry name" value="Ribosomal_L30_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL30 N-terminal eukaryotes" evidence="5">
        <location>
            <begin position="12"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL30-like ferredoxin-like fold" evidence="4">
        <location>
            <begin position="87"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="251" mass="29063" checksum="E1F362A9E3198821" modified="2005-04-12" version="1">MSRFVTKKVPPSESKKLKLERNMKIFSDFQSKIKSDRVKLNDLRKKAKIEALKLQKQYKEHVKSIIDLKRQAKQNGGLYRPAEPKVVFVIRLKGINKLSPKVRKIFQLFRLRQINNGVFLPLNKATIEMLKVIDPFVAYGYPSISMIRKLLYKRGYLKVGKRGSYQRIRIQDNSIIQKKLASKGVYGIEGMVRELFFCGEQFKAVTSLLWPFKLSSPNGGFVRKSTRFTEARGGDCGNRENLINKLIDRMC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVM5</accession>
    <name>Q5CVM5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Thioredoxin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PITHD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627244.1">
        <property type="nucleotide sequence ID" value="XM_627244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVM5"/>
    <dbReference type="STRING" id="353152.Q5CVM5"/>
    <dbReference type="GeneID" id="3374621"/>
    <dbReference type="KEGG" id="cpv:cgd8_3510"/>
    <dbReference type="InParanoid" id="Q5CVM5"/>
    <dbReference type="OMA" id="PCTQELT"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.470">
        <property type="entry name" value="PITH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045099">
        <property type="entry name" value="PITH1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010400">
        <property type="entry name" value="PITH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037047">
        <property type="entry name" value="PITH_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175">
        <property type="entry name" value="AD039 HT014 THIOREDOXIN FAMILY TRP26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12175:SF5">
        <property type="entry name" value="OS03G0795500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06201">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51532">
        <property type="entry name" value="PITH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PITH" evidence="2">
        <location>
            <begin position="1"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025788"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="175" mass="20145" checksum="38B59CEF6DEE8CC9" modified="2005-04-12" version="1" fragment="single">FLIQFLSIIDFIKKTSIECLNEDRNFPFKNALFQTNLEMFCSSLDDHELLAKFNFVQPVNLTGVSFKLLEKDVIEGFGPKKIKLFADATSYSIGDAEIENGTQEFELTKSQLISGECIDLKMVKFKNVNFIQIYISENYGNENTRIGKINIYGEKGDFVDITKWKPYREEKPPLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVT5</accession>
    <name>Q5CVT5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627184.1">
        <property type="nucleotide sequence ID" value="XM_627184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVT5"/>
    <dbReference type="GeneID" id="3374345"/>
    <dbReference type="KEGG" id="cpv:cgd8_2840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2840"/>
    <dbReference type="InParanoid" id="Q5CVT5"/>
    <dbReference type="OrthoDB" id="428826at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="452"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="463"/>
            <end position="477"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="556" mass="60001" checksum="7A729424D2C39132" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW15</accession>
    <name>Q5CW15_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9 10">RNA cytidine acetyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">18S rRNA cytosine acetyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd8_2000</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in 18S rRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in 18S rRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:51424"/>
            <dbReference type="Rhea" id="RHEA-COMP:13575"/>
            <dbReference type="Rhea" id="RHEA-COMP:13576"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a cytidine in tRNA + acetyl-CoA + ATP + H2O = an N(4)-acetylcytidine in tRNA + ADP + phosphate + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53876"/>
            <dbReference type="Rhea" id="RHEA-COMP:13670"/>
            <dbReference type="Rhea" id="RHEA-COMP:13671"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:74900"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
            <location evidence="1 10">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627104.1">
        <property type="nucleotide sequence ID" value="XM_627104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW15"/>
    <dbReference type="FunCoup" id="Q5CW15">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW15"/>
    <dbReference type="GeneID" id="3374492"/>
    <dbReference type="KEGG" id="cpv:cgd8_2000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2000"/>
    <dbReference type="InParanoid" id="Q5CW15"/>
    <dbReference type="OMA" id="HLHYIMS"/>
    <dbReference type="OrthoDB" id="10067491at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990883">
        <property type="term" value="F:18S rRNA cytidine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051392">
        <property type="term" value="F:tRNA cytidine N4-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904812">
        <property type="term" value="P:rRNA acetylation involved in maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051391">
        <property type="term" value="P:tRNA acetylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002218">
        <property type="entry name" value="tRNA(Met) cytidine acetyltransferase TmcA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03211">
        <property type="entry name" value="RNA_acetyltr_Nat10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033688">
        <property type="entry name" value="NAT10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007807">
        <property type="entry name" value="TcmA/NAT10_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032672">
        <property type="entry name" value="TmcA/NAT10/Kre33"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013562">
        <property type="entry name" value="TmcA/NAT10_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027992">
        <property type="entry name" value="tRNA_bind_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925">
        <property type="entry name" value="N-ACETYLTRANSFERASE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10925:SF5">
        <property type="entry name" value="RNA CYTIDINE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13718">
        <property type="entry name" value="GNAT_acetyltr_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05127">
        <property type="entry name" value="NAT10_TcmA_helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08351">
        <property type="entry name" value="TmcA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13725">
        <property type="entry name" value="tRNA_bind_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="TmcA/NAT10 N-terminal" evidence="13">
        <location>
            <begin position="7"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="TcmA/NAT10 helicase" evidence="12">
        <location>
            <begin position="298"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="14">
        <location>
            <begin position="568"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="domain" description="Possible tRNA binding" evidence="15">
        <location>
            <begin position="822"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1017"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="1021"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="303"/>
            <end position="312"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="494"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="669"/>
            <end position="671"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="676"/>
            <end position="682"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="791"/>
        </location>
        <ligand>
            <name>acetyl-CoA</name>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00068357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF05127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF08351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF13718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF13725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK89399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1058" mass="119037" checksum="35D598DB422CA5ED" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW21</accession>
    <name>Q5CW21_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="13">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd8_1940</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the helicase family. RAD25/XPB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="13"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627098.1">
        <property type="nucleotide sequence ID" value="XM_627098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW21"/>
    <dbReference type="SMR" id="Q5CW21"/>
    <dbReference type="FunCoup" id="Q5CW21">
        <property type="interactions" value="424"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW21"/>
    <dbReference type="GeneID" id="3374470"/>
    <dbReference type="KEGG" id="cpv:cgd8_1940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1940"/>
    <dbReference type="InParanoid" id="Q5CW21"/>
    <dbReference type="OMA" id="RCQEIDY"/>
    <dbReference type="OrthoDB" id="10262986at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000112">
        <property type="term" value="C:nucleotide-excision repair factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18029">
        <property type="entry name" value="DEXHc_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18789">
        <property type="entry name" value="SF2_C_XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000077">
        <property type="entry name" value="Probable DNA repair helicase RAD25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050615">
        <property type="entry name" value="ATP-dep_DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032438">
        <property type="entry name" value="ERCC3_RAD25_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006935">
        <property type="entry name" value="Helicase/UvrB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001161">
        <property type="entry name" value="XPB/Ssl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032830">
        <property type="entry name" value="XPB/Ssl2_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00603">
        <property type="entry name" value="rad25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11274">
        <property type="entry name" value="RAD25/XP-B DNA REPAIR HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16203">
        <property type="entry name" value="ERCC3_RAD25_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13625">
        <property type="entry name" value="Helicase_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04851">
        <property type="entry name" value="ResIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00851">
        <property type="entry name" value="XRODRMPGMNTB"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="9" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="16">
        <location>
            <begin position="325"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="17">
        <location>
            <begin position="543"/>
            <end position="721"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="230"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="241"/>
            <end position="252"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006637"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAK89396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="835" mass="94540" checksum="BC4146380D7B29F0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW38</accession>
    <name>Q5CW38_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide, possible ER retention motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_1750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89380.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627081.1">
        <property type="nucleotide sequence ID" value="XM_627081.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW38"/>
    <dbReference type="GeneID" id="3374605"/>
    <dbReference type="KEGG" id="cpv:cgd8_1750"/>
    <dbReference type="InParanoid" id="Q5CW38"/>
    <dbReference type="OMA" id="DCNGGDC"/>
    <dbReference type="OrthoDB" id="343909at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254482" evidence="2">
        <location>
            <begin position="21"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="166"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="234"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="258"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="275"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="286"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89380.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="338" mass="35587" checksum="3BD47E35B2B24EBF" modified="2005-04-12" version="1">MNFPYFFWIIFSILICKVRLEVVIENEDPKADMSALEHLDSSFMQDRGSVGIENLSSNIDLSAGFADNEAQDNSNLSMDKPIEGIDNEKFSIEGLDTNDGFEEVKDSSFQNQLDIEENKNSDHSVGNGIYSEDSILNGSFESKSVDLNDVDKVSAENNLNDKFENLSFSDKSVGGFDEQGKNNDFPEIEENQKDFSSVGKDFSLANKESGEENLPGEYTSTTVVERMDSDQQDSRSSMFRESTLPTPPPQTTESTEVTGGGGGGGNGNGGGFPNTSTSVPTETTTGSGGSGGGSGGGSGGGNGGGSGGGNGGGSGGSGGDGDQNQVGRLNFYDILYEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWE7</accession>
    <name>Q5CWE7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_5390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627857.1">
        <property type="nucleotide sequence ID" value="XM_627857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWE7"/>
    <dbReference type="GeneID" id="3375852"/>
    <dbReference type="KEGG" id="cpv:cgd6_5390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5390"/>
    <dbReference type="InParanoid" id="Q5CWE7"/>
    <dbReference type="OMA" id="SDENTPH"/>
    <dbReference type="OrthoDB" id="343264at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254312" evidence="1">
        <location>
            <begin position="26"/>
            <end position="543"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="543" mass="61814" checksum="BCBACDE3D736465C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWK2</accession>
    <name>Q5CWK2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Splicing factor 3B subunit1-like HEAT repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_4750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3B1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627802.1">
        <property type="nucleotide sequence ID" value="XM_627802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWK2"/>
    <dbReference type="FunCoup" id="Q5CWK2">
        <property type="interactions" value="498"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWK2"/>
    <dbReference type="GeneID" id="3375804"/>
    <dbReference type="KEGG" id="cpv:cgd6_4750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4750"/>
    <dbReference type="InParanoid" id="Q5CWK2"/>
    <dbReference type="OMA" id="LVMNYVW"/>
    <dbReference type="OrthoDB" id="438939at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000039">
        <property type="entry name" value="Splicing factor 3B subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.10.10:FF:000088">
        <property type="entry name" value="Splicing factor 3b, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054573">
        <property type="entry name" value="PP2A/SF3B1-like_HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015016">
        <property type="entry name" value="SF3b_su1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038737">
        <property type="entry name" value="SF3b_su1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12097">
        <property type="entry name" value="SPLICING FACTOR 3B, SUBUNIT 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22646">
        <property type="entry name" value="PPP2R1A-like_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08920">
        <property type="entry name" value="SF3b1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Splicing factor 3B subunit 1" evidence="9">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like HEAT repeat" evidence="10">
        <location>
            <begin position="814"/>
            <end position="891"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="27"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="56"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="79"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005754"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF22646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK90059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1031" mass="116932" checksum="65E0E30A98FE6BFE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWL3</accession>
    <name>Q5CWL3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_4620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627791.1">
        <property type="nucleotide sequence ID" value="XM_627791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWL3"/>
    <dbReference type="FunCoup" id="Q5CWL3">
        <property type="interactions" value="421"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWL3"/>
    <dbReference type="GeneID" id="3376000"/>
    <dbReference type="KEGG" id="cpv:cgd6_4620"/>
    <dbReference type="InParanoid" id="Q5CWL3"/>
    <dbReference type="OMA" id="VRIMRGD"/>
    <dbReference type="OrthoDB" id="1688503at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06089">
        <property type="entry name" value="KOW_RPL26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000009">
        <property type="entry name" value="60S ribosomal protein L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005756">
        <property type="entry name" value="Ribosomal_uL24_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041988">
        <property type="entry name" value="Ribosomal_uL24_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01080">
        <property type="entry name" value="rplX_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11143">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L26 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16906">
        <property type="entry name" value="Ribosomal_L26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="KOW" evidence="5">
        <location>
            <begin position="44"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="135" mass="15388" checksum="EF1C4FF363C73287" modified="2005-04-12" version="1" fragment="single">TDVSSSASKCRKSHFATTSTQRRELMASPLSKELRQKYNVRSLPIRKGDEVMVIRGSNHDYEGVVTRVHRKKFVINVERITRKKTNGESVPIGIHPSNVVITKLKLNRDRRELLARKNRSTKKGKYTNADAADLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWU1</accession>
    <name>Q5CWU1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">subtilisin</fullName>
            <ecNumber evidence="2">3.4.21.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_3730</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.</text>
            <dbReference type="EC" id="3.4.21.62"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627713.1">
        <property type="nucleotide sequence ID" value="XM_627713.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWU1"/>
    <dbReference type="GeneID" id="3375731"/>
    <dbReference type="KEGG" id="cpv:cgd6_3730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3730"/>
    <dbReference type="InParanoid" id="Q5CWU1"/>
    <dbReference type="OMA" id="KMSNACK"/>
    <dbReference type="OrthoDB" id="341834at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255037" description="subtilisin" evidence="5">
        <location>
            <begin position="33"/>
            <end position="2269"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="2251"/>
            <end position="2268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="558"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1048"/>
            <end position="1073"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1144"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1195"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1945"/>
            <end position="1967"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="2149"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="558"/>
            <end position="574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="576"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1048"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1145"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1195"/>
            <end position="1237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1247"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1282"/>
            <end position="1292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1947"/>
            <end position="1958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="2153"/>
            <end position="2170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2269" mass="252701" checksum="FE7045F2C72CABA5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX05</accession>
    <name>Q5CX05_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein with C-terminal RCC1 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_3030</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627649.1">
        <property type="nucleotide sequence ID" value="XM_627649.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX05"/>
    <dbReference type="GeneID" id="3375678"/>
    <dbReference type="KEGG" id="cpv:cgd6_3030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3030"/>
    <dbReference type="InParanoid" id="Q5CX05"/>
    <dbReference type="OMA" id="YNTHENN"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="922"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="1089"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="3">
        <location>
            <begin position="1139"/>
            <end position="1218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="13"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1444" mass="165984" checksum="DDB90BD520359BE4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXE4</accession>
    <name>Q5CXE4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627510.1">
        <property type="nucleotide sequence ID" value="XM_627510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXE4"/>
    <dbReference type="GeneID" id="3376011"/>
    <dbReference type="KEGG" id="cpv:cgd6_1400"/>
    <dbReference type="InParanoid" id="Q5CXE4"/>
    <dbReference type="OMA" id="AFECSNT"/>
    <dbReference type="OrthoDB" id="338107at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="148" mass="17029" checksum="850376B594643337" modified="2007-04-03" version="1">MIYIQDALYLLPDLAPKVTSSLQLEEGEDLNAVKHDILYRANYISTGFECANDLISKMRQLRPLNGEDAERYLNKIEELRSKNDNCVKELKCVSEECTIVLDKLNVSISKYVEDSINKNIISNDTENKMNMTLGEMYEINYHARSNDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXG7</accession>
    <name>Q5CXG7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_1150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627487.1">
        <property type="nucleotide sequence ID" value="XM_627487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXG7"/>
    <dbReference type="GeneID" id="3376031"/>
    <dbReference type="KEGG" id="cpv:cgd6_1150"/>
    <dbReference type="InParanoid" id="Q5CXG7"/>
    <dbReference type="OrthoDB" id="343356at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="235" mass="26124" checksum="406DBCCBC3E67B56" modified="2005-04-12" version="1">MAKGKHNKSLKGERVGVVDIGGSFLTKEILRLENSINTLSHISSEITESLYNFISAFHFNQADFPDSNEFSNLRSEAVVNKLQGSLNAMQNNNANHDYNDQVQSSNLYSNIFSVQSTHNPASCVNAQFSTHFKNGKSIENQIHGNGYLDEQRHQEQFNSEAPKVQSSGNEYSVPTQIPNIEANNAISNPELYIDDTLLQGKDTNFDDASRIEYNGGTPNASTTYEFNSNIYSSLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXI4</accession>
    <name>Q5CXI4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627470.1">
        <property type="nucleotide sequence ID" value="XM_627470.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXI4"/>
    <dbReference type="STRING" id="353152.Q5CXI4"/>
    <dbReference type="GeneID" id="3376093"/>
    <dbReference type="KEGG" id="cpv:cgd6_980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_980"/>
    <dbReference type="InParanoid" id="Q5CXI4"/>
    <dbReference type="OMA" id="CTHEENF"/>
    <dbReference type="OrthoDB" id="1028014at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197:SF251">
        <property type="entry name" value="EG:BACR7C10.4 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="53"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="467" mass="55557" checksum="9DC618038043953E" modified="2005-04-12" version="1">MHKVLDDDDWLSSELQILFDDTYKSNKREKINKSLYDFENRLSRKRANNYISPKIALNSSQESNTWVAFENISKGELILAEKPLCWITTKIGNHFKDYSLVLWKKLIKKCKNDNKLLRNLKLFFPRTQADIKKIRQESENYKIPIKKISRFYEANPDLANKIRFNEALRIYLVVKYNQMSVSTMPELWKNPFYWTEIFSINSLYFKSSFLDHSCSPNVARFYIGTVAVFRALRPIKRKETLSICYIESEYIQDPLWVRSSELNFFCRCELCQKEGRFSPDESTSRIFEINKISRKLNKRCSLISKKYIYMLQGLSLEERISVIEDILVESFLPNEQVNLSKAQKLVGLDASKLIGFLVYDYISYKNLDKAQYWLDIMYRMIHIKDEHNIPVLIIIGLISKDPEIQEKYFRKAARISETVFGSSIKFFMKRYWLDIKLFGKMLYENKRERTSFLRHISSLIRSIFSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXK1</accession>
    <name>Q5CXK1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative extracellular protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_780</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627453.1">
        <property type="nucleotide sequence ID" value="XM_627453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXK1"/>
    <dbReference type="STRING" id="353152.Q5CXK1"/>
    <dbReference type="GeneID" id="3375995"/>
    <dbReference type="KEGG" id="cpv:cgd6_780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_780"/>
    <dbReference type="InParanoid" id="Q5CXK1"/>
    <dbReference type="OMA" id="TNICEEG"/>
    <dbReference type="OrthoDB" id="336181at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052065">
        <property type="entry name" value="Compl_asym_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22906:SF43">
        <property type="entry name" value="PROPERDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="597"/>
            <end position="620"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="551"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="625" mass="70595" checksum="094B28A146014684" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXK5</accession>
    <name>Q5CXK5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">14-3-3 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_730</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627449.1">
        <property type="nucleotide sequence ID" value="XM_627449.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXK5"/>
    <dbReference type="GeneID" id="3376056"/>
    <dbReference type="KEGG" id="cpv:cgd6_730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_730"/>
    <dbReference type="InParanoid" id="Q5CXK5"/>
    <dbReference type="OrthoDB" id="342158at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032682">
        <property type="entry name" value="Cnd1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF1">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12717">
        <property type="entry name" value="Cnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin complex subunit 1 C-terminal" evidence="7">
        <location>
            <begin position="1619"/>
            <end position="1762"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="213"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="527"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="240"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="537"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1937" mass="225099" checksum="19B4EF336CA47BE5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXS3</accession>
    <name>Q5CXS3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">A surface protein with 2 conserved cysteines</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_5140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628657.1">
        <property type="nucleotide sequence ID" value="XM_628655.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXS3"/>
    <dbReference type="STRING" id="353152.Q5CXS3"/>
    <dbReference type="GeneID" id="3372089"/>
    <dbReference type="KEGG" id="cpv:cgd7_5140"/>
    <dbReference type="InParanoid" id="Q5CXS3"/>
    <dbReference type="OMA" id="NIWINAI"/>
    <dbReference type="OrthoDB" id="340921at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253952" evidence="1">
        <location>
            <begin position="20"/>
            <end position="258"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="258" mass="27921" checksum="A2B39B83111FA550" modified="2005-04-12" version="1">MARISIATLFLASIALVKGAKTHLGLSESVFNQLVNKGYTKSDIESLVGTIRSSLLTVDDEQIGQCGEGLKGLLDRQLIPGDPDALERVSGIIHQGNFQLFRGKLPIVTLSSTSILLPIDSISDICFGIRSDKGIGYNVCTKNRNMRNIWMNAITEMVLCEKTGVRSGKLPAISKKQNVLAGSNVGELKPSGIDIIIKDSSQGKPFLTINGKPISQIIQKQTMAAQNALTTPKGEESEEDSVEIPAEIDGKFFYQLMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXS8</accession>
    <name>Q5CXS8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SET domain protein with MYND insert (Skm/BOP family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_5090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628652.1">
        <property type="nucleotide sequence ID" value="XM_628650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXS8"/>
    <dbReference type="STRING" id="353152.Q5CXS8"/>
    <dbReference type="GeneID" id="3371751"/>
    <dbReference type="KEGG" id="cpv:cgd7_5090"/>
    <dbReference type="InParanoid" id="Q5CXS8"/>
    <dbReference type="OMA" id="ADPDICC"/>
    <dbReference type="OrthoDB" id="265717at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050869">
        <property type="entry name" value="H3K4_H4K5_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002893">
        <property type="entry name" value="Znf_MYND"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12197">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144232">
        <property type="entry name" value="HIT/MYND zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01360">
        <property type="entry name" value="ZF_MYND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50865">
        <property type="entry name" value="ZF_MYND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SET" evidence="5">
        <location>
            <begin position="19"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="MYND-type" evidence="6">
        <location>
            <begin position="64"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="587" mass="67808" checksum="D6608F464D74390E" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY36</accession>
    <name>Q5CY36_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628544.1">
        <property type="nucleotide sequence ID" value="XM_628542.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372130"/>
    <dbReference type="KEGG" id="cpv:cgd7_3820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3820"/>
    <dbReference type="InParanoid" id="Q5CY36"/>
    <dbReference type="OMA" id="PIVEANW"/>
    <dbReference type="OrthoDB" id="337240at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255080" evidence="1">
        <location>
            <begin position="26"/>
            <end position="1421"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1421" mass="166122" checksum="0A6CAFAB4BEA8101" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY68</accession>
    <name>Q5CY68_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cytidylyltransferase (HIGH family) exon-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628512.1">
        <property type="nucleotide sequence ID" value="XM_628510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY68"/>
    <dbReference type="STRING" id="353152.Q5CY68"/>
    <dbReference type="GeneID" id="3371960"/>
    <dbReference type="KEGG" id="cpv:cgd7_3480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3480"/>
    <dbReference type="InParanoid" id="Q5CY68"/>
    <dbReference type="OrthoDB" id="330671at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016779">
        <property type="term" value="F:nucleotidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02164">
        <property type="entry name" value="PPAT_CoAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="624" mass="71508" checksum="6AB84E254DD1A51D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYI1</accession>
    <name>Q5CYI1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_2250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628399.1">
        <property type="nucleotide sequence ID" value="XM_628397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYI1"/>
    <dbReference type="FunCoup" id="Q5CYI1">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYI1"/>
    <dbReference type="GeneID" id="3372201"/>
    <dbReference type="KEGG" id="cpv:cgd7_2250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2250"/>
    <dbReference type="InParanoid" id="Q5CYI1"/>
    <dbReference type="OMA" id="NKKKWMI"/>
    <dbReference type="OrthoDB" id="10248446at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02413">
        <property type="entry name" value="KH-II_40S_S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1140.32:FF:000004">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.300.20:FF:000006">
        <property type="entry name" value="40S ribosomal protein S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1140.32">
        <property type="entry name" value="Ribosomal protein S3, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015946">
        <property type="entry name" value="KH_dom-like_a/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004044">
        <property type="entry name" value="KH_dom_type_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009019">
        <property type="entry name" value="KH_sf_prok-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036419">
        <property type="entry name" value="Ribosomal_S3_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057258">
        <property type="entry name" value="Ribosomal_uS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001351">
        <property type="entry name" value="Ribosomal_uS3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005703">
        <property type="entry name" value="Ribosomal_uS3_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003219">
        <property type="entry name" value="PRK04191.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01008">
        <property type="entry name" value="uS3_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11760:SF32">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07650">
        <property type="entry name" value="KH_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00189">
        <property type="entry name" value="Ribosomal_S3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54814">
        <property type="entry name" value="Prokaryotic type KH domain (KH-domain type II)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54821">
        <property type="entry name" value="Ribosomal protein S3 C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50823">
        <property type="entry name" value="KH_TYPE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="KH type-2" evidence="7">
        <location>
            <begin position="22"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="221" mass="24851" checksum="501B52095E1FF3AD" modified="2005-04-12" version="1">MAPQLISKKRKFINDGVFEAELNEFLSCTLAEDGYAGVEVRVTPIKTEIIIRATRTREVLGVKGRRIRELTSLIQKRFNFPEGSVELFAERIENRGLCAMAQAESLRYKLLKGVAVRRACYGVLRHVMESGAKGCEVIVSGKLRAQRAKSMKFRDGYMIATGQPFRDFVDKAVRNVMMKQGVLGVQVKIMLPYDPEGKTGPSKPLPDAVMVREPKEYPINQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYS2</accession>
    <name>Q5CYS2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_1230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628308.1">
        <property type="nucleotide sequence ID" value="XM_628306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYS2"/>
    <dbReference type="GeneID" id="3371853"/>
    <dbReference type="KEGG" id="cpv:cgd7_1230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1230"/>
    <dbReference type="InParanoid" id="Q5CYS2"/>
    <dbReference type="OMA" id="CINTTIR"/>
    <dbReference type="OrthoDB" id="337429at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="457" mass="52568" checksum="FCC6963EEA95AEEF" modified="2005-04-12" version="1">MHLKEFILSLDDVRALVERKLERNREFKPKISFIKHLASYSVTIPSLTKISDEALKIAKKDGNEKAIYMDTIIVPALPRSLKREDNLSSLQCRFSYSQKPCSISPTTHYDLLSNIFGYENSQDANIFADRFCLRRLIDFSLGSISSENADIMVSTKLRIDDNGELERISPIKMLPINITEGFPSVGFQFETYLTRSEIGLGLNPDATLKMADSCFVVDEISFGDLRLIRRCEIDAVSKRHVYGDSKERSKQEEYKNSLCHKSWEQKIYNTDTEFMERRMSPPCRVFLSDNFKSSKLSPENRVEIKSISCRNTHNFSWVSVYFQMLIGSTPILIRGCHNRGFFTQRSITSFNLDQVKEFSEKELTARKIPNLDFSESNWDTITSAIAFSEAILTYISNDLLELIGSYLFKENGPGDHFVNFTIKKKENNIIFQILNPNENLPNIAGPINYWNDYLSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYS5</accession>
    <name>Q5CYS5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_1200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628305.1">
        <property type="nucleotide sequence ID" value="XM_628303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYS5"/>
    <dbReference type="STRING" id="353152.Q5CYS5"/>
    <dbReference type="GeneID" id="3371850"/>
    <dbReference type="KEGG" id="cpv:cgd7_1200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1200"/>
    <dbReference type="InParanoid" id="Q5CYS5"/>
    <dbReference type="OMA" id="SKCEDIP"/>
    <dbReference type="OrthoDB" id="10250320at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="558"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="587"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="927"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="632"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="657"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="677"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="726"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="929"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1013" mass="111817" checksum="FC9EB17962F83E1E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYW3</accession>
    <name>Q5CYW3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628267.1">
        <property type="nucleotide sequence ID" value="XM_628265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYW3"/>
    <dbReference type="GeneID" id="3372020"/>
    <dbReference type="KEGG" id="cpv:cgd7_780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_780"/>
    <dbReference type="InParanoid" id="Q5CYW3"/>
    <dbReference type="OrthoDB" id="340557at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="491" mass="54504" checksum="19360827D6DCD0DE" modified="2005-04-12" version="1">MIKQELNFGNDRIIHSAQNENTYKTVKTAEISPLRSGLMINEESEEKFGVGAMNNRGSASLGLNSGFSENYYSGFPTQQPQVYFQTKNIPMFSEAMSSGQHISIGGYNMLSSHSVGPVFQQSENTNYMTNTSSGMQIKRLNIPSNSVKSVSTIPSNGVSDIPIIGGTSGYEYKDGSVLNGVCQQPFQTQNLAKNITGNSSNLHITGNKSTKIQENLNLNTNSSSITIHPNNTNNSNVYPSEKPLPSARAKDDYLQYEQYSSVNTKSFISQQNTALQTNFQSNNLSNVPFFSTNTSNPNQMNSLMNPHYLNSVPLLAQIRIECIQDLPNNFHHHSMGIYSSITNMDYSIVASFNNIDDKNETYRIGPFPSSSMSNSKLNCIVQDEISIPFSWSQPILKLKILEENDFKADIIGVCSISIDMSSIGIPSQACLIDPQTNQVRGTLRFVVKLVPNQQNPNYRFDQIHGPNSILNRRYSHDDSIFNIFKGFCCAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYZ5</accession>
    <name>Q5CYZ5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16 17">Phosphatidate cytidylyltransferase</fullName>
            <ecNumber evidence="6 16 17">2.7.7.41</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">cgd7_450</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 16 17">
            <text>a 1,2-diacyl-sn-glycero-3-phosphate + CTP + H(+) = a CDP-1,2-diacyl-sn-glycerol + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:16229"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:58332"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="EC" id="2.7.7.41"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3 16 17">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 16 17">Belongs to the CDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6 16 17"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628235.1">
        <property type="nucleotide sequence ID" value="XM_628233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYZ5"/>
    <dbReference type="FunCoup" id="Q5CYZ5">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYZ5"/>
    <dbReference type="GeneID" id="3372024"/>
    <dbReference type="KEGG" id="cpv:cgd7_450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_450"/>
    <dbReference type="InParanoid" id="Q5CYZ5"/>
    <dbReference type="OMA" id="FVIESTM"/>
    <dbReference type="OrthoDB" id="10260889at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000374">
        <property type="entry name" value="PC_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016720">
        <property type="entry name" value="PC_Trfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13773:SF8">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, PHOTORECEPTOR-SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01148">
        <property type="entry name" value="CTP_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018269">
        <property type="entry name" value="PC_trans_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01315">
        <property type="entry name" value="CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 16" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="12 16" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10 16 17" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="14 16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="15 16" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 16 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="164"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="270"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="18">
        <location>
            <begin position="17"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="18">
        <location>
            <begin position="29"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRNR" id="PIRNR018269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU003938"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAK90504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="450" mass="51510" checksum="3B764485BB60E464" modified="2005-04-12" version="1">MKNSRYIRSNSIFDDTEHETESDNFFSEVELRRRNGNRKESSEKNGHKEGNKNGIIENSKITGNHSSTNNSGDLNWVTRTIWTIILLSSFLVILAAGHTYSAMLVLILISAVYQEVNSLKRSAEEDKRLPFFYTLRWYWLGVTLFSTGKLWWVPLIEKYRRNYYLLYLIVYYHSLISYVGALFGFIAFILSLRNYTLRYQFSQFGIMILSLLLVVTQSVFMIANTYRGLIWFILPSCLVICNDIFAYIVGKIFGKTRLFRLSPKKTVEGFIGASIITIFAAIILGNVLSKSQIFICPQNELLEKPFSMWYELKCDPNPVFIQKPYNIPPFLHFIFGKEPFLIPDSQFHAIAIGIFAAFVAPFGGFFASGLKRALRIKDFGSAIPGHGGITDRFDCQILIGLFTYLYIRAFIFTNPKSVSLDIVIKLAKMLPEPEIQHLISVLSSHISSQQ</sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPQ6</accession>
    <name>ASNA_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">ATPase ASNA1 homolog</fullName>
            <ecNumber evidence="1">3.6.-.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Arsenical pump-driving ATPase homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Arsenite-stimulated ATPase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">cgd7_4070</name>
    </gene>
    <organism>
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the arsA ATPase family.</text>
    </comment>
    <dbReference type="EC" id="3.6.-.-" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388402.1">
        <property type="nucleotide sequence ID" value="XM_001388365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPQ6"/>
    <dbReference type="SMR" id="A3FPQ6"/>
    <dbReference type="FunCoup" id="A3FPQ6">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPQ6"/>
    <dbReference type="EnsemblProtists" id="EAZ51595">
        <property type="protein sequence ID" value="EAZ51595"/>
        <property type="gene ID" value="cgd7_4070"/>
    </dbReference>
    <dbReference type="GeneID" id="3371804"/>
    <dbReference type="KEGG" id="cpv:cgd7_4070"/>
    <dbReference type="InParanoid" id="A3FPQ6"/>
    <dbReference type="OMA" id="IGNNEPR"/>
    <dbReference type="OrthoDB" id="1770at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043529">
        <property type="term" value="C:GET complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071816">
        <property type="term" value="P:tail-anchored membrane protein insertion into ER membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02035">
        <property type="entry name" value="ArsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001459">
        <property type="entry name" value="ATPase ASNA1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03112">
        <property type="entry name" value="Asna1_Get3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025723">
        <property type="entry name" value="ArsA/GET3_ATPase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016300">
        <property type="entry name" value="ATPase_ArsA/GET3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027542">
        <property type="entry name" value="ATPase_ArsA/GET3_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00345">
        <property type="entry name" value="GET3_arsA_TRC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803">
        <property type="entry name" value="ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10803:SF3">
        <property type="entry name" value="ATPASE GET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02374">
        <property type="entry name" value="ArsA_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0067">ATP-binding</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword id="KW-0378">Hydrolase</keyword>
    <keyword id="KW-0547">Nucleotide-binding</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0813">Transport</keyword>
    <feature type="chain" id="PRO_0000388166" description="ATPase ASNA1 homolog">
        <location>
            <begin position="1"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="active site" evidence="1">
        <location>
            <position position="62"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="33"/>
            <end position="40"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03112"/>
        </source>
    </evidence>
    <sequence length="366" mass="40886" checksum="F1FCC2E2BDE1CECC" modified="2007-04-03" version="1">MSTAYFDADCDLEPSLKSLFSLKTLKWIFVGGKGGVGKTTTSCSIASRLAEERESVLILSTDPAHNLSDAFVQKFSNAPTLVNGYKNLYAMELDASYQQAVEFKLKEENSLFSKFLPDLISALPGIDEALGFATLMQSVKSMSYSVIVFDTAPTGHTLRLLSFPSLLEKGLSKLFSIKQNMSGALQLINSVSGNAIEEETLNSKLEDLKAITTSVKETFQDPSKTTFVCVCIPEFLSVYETERLIQELAKQSISCSHIVVNQVMFPIDLPSGNDQGESVLKDSSELLKLEDIPSDHSKLVEFTEKIVCSYNKLLSYSKLLYSKYYSKRNMQMKYLEQIRDLYSYDFHVAYIPTLNNEVSKIRVLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPT0</accession>
    <name>A3FPT0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNAJ protein-like, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51503.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388309.1">
        <property type="nucleotide sequence ID" value="XM_001388272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPT0"/>
    <dbReference type="SMR" id="A3FPT0"/>
    <dbReference type="GeneID" id="3375934"/>
    <dbReference type="KEGG" id="cpv:cgd6_1190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1190"/>
    <dbReference type="InParanoid" id="A3FPT0"/>
    <dbReference type="OMA" id="FPTWREY"/>
    <dbReference type="OrthoDB" id="445556at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042977">
        <property type="entry name" value="AtJ6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056453">
        <property type="entry name" value="HTH_DNAJC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44916">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44916:SF1">
        <property type="entry name" value="CHAPERONE DNAJ-DOMAIN SUPERFAMILY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23302">
        <property type="entry name" value="HTH_DNAJC9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="1">
        <location>
            <begin position="6"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51503.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="247" mass="29211" checksum="AC889A53DBA8C917" modified="2007-04-03" version="1">MVKDIRLYEIIGVSPNAGAAEIKKEYRLRALALHPDKNQNDEKSKERFQELQKAYEILRNEESRKLYDETGIIEGEEGKKFDDIINYFKQFTKKISEKDIQEYKERYRGSDDEWEDLSNFYLRFNGNCKLLLEYIPFSEPEDINYYVSMIEDAIKDGRLPQKKEFKGSIKELHAQGKKWKAKMKREKSKHSSNMEDLVQAIQSSSKKRMGGFASIISKFSDDSFEEVDESKFQEIQENLLKNKKKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPU0</accession>
    <name>A3FPU0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative kinesin heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_1920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388319.1">
        <property type="nucleotide sequence ID" value="XM_001388282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPU0"/>
    <dbReference type="SMR" id="A3FPU0"/>
    <dbReference type="STRING" id="353152.A3FPU0"/>
    <dbReference type="GeneID" id="3375944"/>
    <dbReference type="KEGG" id="cpv:cgd6_1920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1920"/>
    <dbReference type="InParanoid" id="A3FPU0"/>
    <dbReference type="OMA" id="RIEQANC"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01374">
        <property type="entry name" value="KISc_CENP_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF75">
        <property type="entry name" value="CENTROMERE-ASSOCIATED PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1 4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 3" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="5">
        <location>
            <begin position="60"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="426"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="676"/>
            <end position="703"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="758"/>
            <end position="823"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="139"/>
            <end position="146"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="925" mass="106961" checksum="6163110523B7BF1D" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPV0</accession>
    <name>A3FPV0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_2750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C85 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388329.1">
        <property type="nucleotide sequence ID" value="XM_001388292.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPV0"/>
    <dbReference type="STRING" id="353152.A3FPV0"/>
    <dbReference type="GeneID" id="3375954"/>
    <dbReference type="KEGG" id="cpv:cgd6_2750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2750"/>
    <dbReference type="InParanoid" id="A3FPV0"/>
    <dbReference type="OrthoDB" id="342198at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061578">
        <property type="term" value="F:K63-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF4">
        <property type="entry name" value="OTU DOMAIN-CONTAINING PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8" id="KW-0645">Protease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="OTU" evidence="7">
        <location>
            <begin position="11"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="399" mass="46449" checksum="D91ED4317983ABD6" modified="2007-04-03" version="1">MREECLLPYEVRVKNIEGDGNCLFRSIGSQLYGESEHHEIIRSACMDYVDLNKESFSGFVHEYSSIEKYIQEKRKLGVWADNIEVQALSDLYRIPIYIFEKVRNSKLNASLLEKHRLEGFSGTMSENIFYENKEFVYKLLCKIEPRHSSFLDQIKNYYSNSRPIRLLYYNDLHYDSLFYRREHQTPIINKDIGIIEAESIKNLKVYRAIAKQKEKSSKFPVRGSKIKTDQVGHFNHTSYALLRKKAIKKFPVNYGSSSESDNYVAKSPFFLSVKNKYRDEPESFFEGNYLDKISEGETHFEKLHPKSKEPHSKFISGPKSFSERAIGKPACVSKIKSLNNTHLGVVDRYARDVQLSSHQKEFKKLLINDSPRLSSTPNPRKKCVAIYCPQILKQSAFRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPV3</accession>
    <name>A3FPV3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">T24f1.1 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_2800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the GTR/RAG GTP-binding protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388332.1">
        <property type="nucleotide sequence ID" value="XM_001388295.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPV3"/>
    <dbReference type="IntAct" id="A3FPV3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPV3"/>
    <dbReference type="GeneID" id="3375956"/>
    <dbReference type="KEGG" id="cpv:cgd6_2800"/>
    <dbReference type="InParanoid" id="A3FPV3"/>
    <dbReference type="OMA" id="LIPNMQD"/>
    <dbReference type="OrthoDB" id="10020193at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990131">
        <property type="term" value="C:Gtr1-Gtr2 GTPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009267">
        <property type="term" value="P:cellular response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010507">
        <property type="term" value="P:negative regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11384">
        <property type="entry name" value="RagA_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006762">
        <property type="entry name" value="Gtr1_RagA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039397">
        <property type="entry name" value="RagA/B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259">
        <property type="entry name" value="RAS-RELATED GTP BINDING RAG/GTR YEAST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11259:SF1">
        <property type="entry name" value="RAS-RELATED GTP-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04670">
        <property type="entry name" value="Gtr1_RagA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007756"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="340" mass="39136" checksum="C527142D0B6F5273" modified="2007-04-03" version="1" fragment="single">MNSDRKKVLLMGRAGAGKTSMRSIIFANYLPKDTSRLTATNNIEHSHLRFFGNMVLSLWDCGGQDIFMENYFESQREHIFRSTEVLIYVLEVRKDYSSKHATKDIEQDFAYFKSTVENLKLLSPKSHLFCLVHKMDKLSAIERESAINYYEREIGRVASNMNYRVFPTTIWDETLFAAWSEIVYALIPNVGLLEKNLKILAESCNAVELVLFEKSTFLVISHAENSNTLDSKHHRSRFERISNICKQFKLTCAKSQTNFVGINLETPNFSSIIKRFTQNSYILVVINDKSKLINNQVTIKYHLINVKLGVTSASALYNIEHARDHFETIIASHLNSEINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPX6</accession>
    <name>A3FPX6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Serine/threonine-protein kinase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_4960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388355.1">
        <property type="nucleotide sequence ID" value="XM_001388318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPX6"/>
    <dbReference type="STRING" id="353152.A3FPX6"/>
    <dbReference type="GeneID" id="3375980"/>
    <dbReference type="KEGG" id="cpv:cgd6_4960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4960"/>
    <dbReference type="InParanoid" id="A3FPX6"/>
    <dbReference type="OMA" id="DTEVITM"/>
    <dbReference type="OrthoDB" id="343108at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF110">
        <property type="entry name" value="NON-SPECIFIC SERINE_THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="3">
        <location>
            <begin position="43"/>
            <end position="444"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="445" mass="51981" checksum="F8AAA2F2F4AF56DB" modified="2007-04-03" version="1">MIFKIKSLLNLDRNGFLWVLVKTNIENDDLSVNYCLNNYAYNSSKEGFLGEGSYFRAYRGRKLFSFNKDSVGSILTTLKIGLLSCLKSHKVALVMENNQKIILSVYERVILEYLIMRKLNHSSIPRVLDLIEVPESNQIVLVHEYLPFQLMYWNRYGKFYSVINNSRRIMVYSEKISIIILYQLLVCVDYLHEHRIVHRDIKPENIFLTEKVDESDLICTFEDLNSLDEDEEDEDELFEEKCLWEDAPIFESTSGAKAEQIRLLRERDVEEEEEKTDFLGRSSLMQLLVLKEYMEYFKKDFPSTNKESDTALKFISKFQVKLSDFNSSIIVNDSGLIYDSEGSMLFTPPECFKLECTKDGIDGFKRDIWSIGCVMYCILNGSPPFFGQDTRELLRSIKENSENLVFNREGISLETRMLIQDMLCIDPINRISVKNAIERVRKMLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ44</accession>
    <name>A3FQ44_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_3530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388124.1">
        <property type="nucleotide sequence ID" value="XM_001388087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ44"/>
    <dbReference type="STRING" id="353152.A3FQ44"/>
    <dbReference type="GeneID" id="3373822"/>
    <dbReference type="KEGG" id="cpv:cgd3_3530"/>
    <dbReference type="InParanoid" id="A3FQ44"/>
    <dbReference type="OrthoDB" id="338816at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045893">
        <property type="term" value="P:positive regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039128">
        <property type="entry name" value="TRIP4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12963">
        <property type="entry name" value="THYROID RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAZ51452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="192" mass="22219" checksum="F882CF13FAFBEAC4" modified="2007-04-03" version="1" fragment="single">MRSIRISDIQFQQKKGNKKNKKNNISGYDNKISDSNIGADSSVLVECGCYAKLHAIYITCIQCGKLRIKISFLGRISCELEKDIIELNNECIFCKSKLVKDESGDFISEGNNEDEEIAHYFQALERRDRLLEYAKNSTSRTRVIDEETDWFSEFENPWNTKDERLLALKMSKECAESAAKSRFSKYIFVIRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ49</accession>
    <name>A3FQ49_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="10">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd3_3920</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7 10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="10">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388129.1">
        <property type="nucleotide sequence ID" value="XM_001388092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ49"/>
    <dbReference type="FunCoup" id="A3FQ49">
        <property type="interactions" value="466"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ49"/>
    <dbReference type="GeneID" id="3373817"/>
    <dbReference type="KEGG" id="cpv:cgd3_3920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3920"/>
    <dbReference type="InParanoid" id="A3FQ49"/>
    <dbReference type="OMA" id="LMEFHSQ"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17942">
        <property type="entry name" value="DEADc_DDX18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000379">
        <property type="entry name" value="RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044773">
        <property type="entry name" value="DDX18/Has1_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="14">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="57"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="258"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="473"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="8">
        <location>
            <begin position="26"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="476"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="508"/>
            <end position="519"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAZ51457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="519" mass="58471" checksum="BDDAA186A8CAADD7" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ56</accession>
    <name>A3FQ56_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Calmodulin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd2_810</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the calmodulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388192.1">
        <property type="nucleotide sequence ID" value="XM_001388155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ56"/>
    <dbReference type="SMR" id="A3FQ56"/>
    <dbReference type="STRING" id="353152.A3FQ56"/>
    <dbReference type="GeneID" id="3373427"/>
    <dbReference type="KEGG" id="cpv:cgd2_810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_810"/>
    <dbReference type="InParanoid" id="A3FQ56"/>
    <dbReference type="OMA" id="ARKMKEC"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000042">
        <property type="entry name" value="Calmodulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000398">
        <property type="entry name" value="Calmodulin-like protein 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF0">
        <property type="entry name" value="CALMODULIN LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="7" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="8"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="44"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="81"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="9">
        <location>
            <begin position="117"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="149" mass="16765" checksum="E0634F1FD4F4E81D" modified="2007-04-03" version="1">MAEQLTEEQIAEFKEAFSLFDKDGDGSITTKELGTVMRSLGQNPTEAELLDMINEVDADGNGTIDFPEFLSLMARKMKDTDTEDELIEAFKVFDRDGNGFISAAELRHVMTNLGEKLSDEEVDEMIREADVDGDGQIMYEEFTKMMLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQK4</accession>
    <name>A3FQK4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Small nuclear ribonucleoprotein E</fullName>
            <shortName evidence="11">snRNP-E</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Sm protein E</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd4_1660</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388059.1">
        <property type="nucleotide sequence ID" value="XM_001388022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQK4"/>
    <dbReference type="FunCoup" id="A3FQK4">
        <property type="interactions" value="396"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQK4"/>
    <dbReference type="GeneID" id="3372831"/>
    <dbReference type="KEGG" id="cpv:cgd4_1660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1660"/>
    <dbReference type="InParanoid" id="A3FQK4"/>
    <dbReference type="OMA" id="KVMTQPI"/>
    <dbReference type="OrthoDB" id="25620at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005687">
        <property type="term" value="C:U4 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01718">
        <property type="entry name" value="Sm_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027078">
        <property type="entry name" value="snRNP-E"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11193">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 11" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="12">
        <location>
            <begin position="17"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU365053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAZ51247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="92" mass="10875" checksum="3C4C72BC665FCF0D" modified="2007-04-03" version="1" fragment="single">MNSQTKRKTQKMMLQPINQIFHLFTSKQRVQIWLYDHKNLVLEGVIQGFDEYMNIVLDQASEVYTKKEVRRETSVGQLLLRGENISLICECK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQK6</accession>
    <name>A3FQK6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd4_2050</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388061.1">
        <property type="nucleotide sequence ID" value="XM_001388024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQK6"/>
    <dbReference type="STRING" id="353152.A3FQK6"/>
    <dbReference type="GeneID" id="3372829"/>
    <dbReference type="KEGG" id="cpv:cgd4_2050"/>
    <dbReference type="InParanoid" id="A3FQK6"/>
    <dbReference type="OMA" id="FTRCARI"/>
    <dbReference type="OrthoDB" id="342627at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="1"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00040674"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="133" mass="14498" checksum="8F90528928163E10" modified="2007-04-03" version="1" fragment="single">IGGGIIIGKGIIELCGVPGSGKTLLCKILALNIQIPKSIGGPGLNAIYIGDSEGGFSDNRLREISKSTLNYINAKKKTEDMTCENLIKNIKYIRIFDLEELINVLTLLPSVSLKQSFELFTIFTRCARIIILA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPI3</accession>
    <name>Q5CPI3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625366.1">
        <property type="nucleotide sequence ID" value="XM_625366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPI3"/>
    <dbReference type="GeneID" id="3375646"/>
    <dbReference type="KEGG" id="cpv:cgd6_300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_300"/>
    <dbReference type="InParanoid" id="Q5CPI3"/>
    <dbReference type="OrthoDB" id="338739at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="220" mass="25852" checksum="4E3AFF8610959BD3" modified="2005-04-12" version="1">MYITKPINWPVKSTIYKWLRAYWFDDASLISPIRLCTTLFMDKTYKDEKHSMSTSARFVQLGFFGALRFGSNRIDIYSPSNGYQILSLRKVGINLPPYVPFSLGSVVIPESDSYKINTNIQQSYYNQNNQAGYYVDDYNNYYGNPNFEYDNNNYYNEQIIFNGMGLVQNITENINNTRTKVNNNSTKIIKKEQNIDNYHYKFGLENINEAENIYIRRNLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPU4</accession>
    <name>Q5CPU4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625420.1">
        <property type="nucleotide sequence ID" value="XM_625420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPU4"/>
    <dbReference type="GeneID" id="3372424"/>
    <dbReference type="KEGG" id="cpv:cgd4_3990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3990"/>
    <dbReference type="InParanoid" id="Q5CPU4"/>
    <dbReference type="OMA" id="PITRHIN"/>
    <dbReference type="OrthoDB" id="337798at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="580" mass="67174" checksum="6B07566328499E85" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPY6</accession>
    <name>Q5CPY6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA polymerase III C5 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_300</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625493.1">
        <property type="nucleotide sequence ID" value="XM_625493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPY6"/>
    <dbReference type="FunCoup" id="Q5CPY6">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPY6"/>
    <dbReference type="GeneID" id="3372511"/>
    <dbReference type="KEGG" id="cpv:cgd8_300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_300"/>
    <dbReference type="InParanoid" id="Q5CPY6"/>
    <dbReference type="OMA" id="KKKCRAF"/>
    <dbReference type="OrthoDB" id="270173at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07032">
        <property type="entry name" value="RNAP_I_II_AC40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.120.12">
        <property type="entry name" value="DNA-directed RNA polymerase, insert domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00320">
        <property type="entry name" value="RNApol_arch_Rpo3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011262">
        <property type="entry name" value="DNA-dir_RNA_pol_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011263">
        <property type="entry name" value="DNA-dir_RNA_pol_RpoA/D/Rpb3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022842">
        <property type="entry name" value="RNAP_Rpo3/Rpb3/RPAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033901">
        <property type="entry name" value="RNAPI/III_AC40"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036643">
        <property type="entry name" value="RNApol_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050518">
        <property type="entry name" value="Rpo3/RPB3_RNA_Pol_subunit"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001988">
        <property type="entry name" value="PRK00783.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11800:SF13">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01000">
        <property type="entry name" value="RNA_pol_A_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01193">
        <property type="entry name" value="RNA_pol_L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00662">
        <property type="entry name" value="RPOLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56553">
        <property type="entry name" value="Insert subdomain of RNA polymerase alpha subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RpoA/D/Rpb3-type" evidence="4">
        <location>
            <begin position="66"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025804"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="344" mass="38869" checksum="C9E6E716544C053B" modified="2005-04-12" version="1">MVSEKKERNNRYLECTTEGPRNVGGYGYIGSNELNSIIKGDNYRKQTVEEIIETIDIKVNELKSDYINFDISGIDASIANALRRILLVEIPTVAIETVQIYQNNGVIQDEVLAHRLGLIPMLIDPNTIEFRNEDEDLNEKNSVCFKLNVKCTKDDINHEKGITSKAIYSKDLVWIPLSDNQRKKFGKTPPKVVTDDILITKLRPGQSIEAILYCEKNIGRVHAKWSPVCTASYRLLPEFGFPNGPISGSDALKLRDTVCPMKVFDIEDVTGNAVPTNPRNCTTCRACIEKFPNKIKLLKDKFHFIFSIETTGCIPPVELVKTAIDILRKKGEKIKSSVKLFYEQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ19</accession>
    <name>Q5CQ19_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_4460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625607.1">
        <property type="nucleotide sequence ID" value="XM_625607.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ19"/>
    <dbReference type="GeneID" id="3372550"/>
    <dbReference type="KEGG" id="cpv:cgd5_4460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4460"/>
    <dbReference type="InParanoid" id="Q5CQ19"/>
    <dbReference type="OrthoDB" id="10296210at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="340" mass="41048" checksum="99037B22DD70CB1E" modified="2005-04-12" version="1">MELILNWNHINNSIKGYINQLKNDLLINIWINYDFIQMFMIPSSFSCRFIYMRIHFWINILSIPLSKMLINSNEDFNNVRITLEYPMKYFKKLLIIKDFNIFKENIINFSINFIIDSVRLIQLSYFKIILKMFISKIQKNNTLHNLEFEEFTKFIFKLITYMKLISNKTKLELESNHVNNQFKIDNNTKCDIIDIISLLISYLNQVSEAVHDFLVIRQEFIQNNNNDNNNNNDFKIDDKPIQQINYELLKKKTEWINYFIYSSNLNYSDHSENITKFNILEYILNHNNKYSLSIEFQKLPKIFQYIKKETSKMTIHKLQFFNNLTFSDCTFSNTNTIQLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ49</accession>
    <name>Q5CQ49_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_4140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625577.1">
        <property type="nucleotide sequence ID" value="XM_625577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ49"/>
    <dbReference type="GeneID" id="3372529"/>
    <dbReference type="KEGG" id="cpv:cgd5_4140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4140"/>
    <dbReference type="InParanoid" id="Q5CQ49"/>
    <dbReference type="OMA" id="IVYYETH"/>
    <dbReference type="OrthoDB" id="338434at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="198"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="233"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="274" mass="31353" checksum="F81DE51ED46AE1D5" modified="2005-04-12" version="1">MDSEKSVERGRKINKDRGSERVGVIGRKMSDMDKILPSKEHIEEGLAPNEGELAIIYHDTTAGSTKHIVTKSPNISPAKQEESSLLGNNSFQNYVNPHSLYSPVYTSNQIGGEYAFPKVKFSSLIFPWSAFLAVIISYVLTSFSWYYLFYNDDYRLVLAPFVTSSIICFFESPVMLAKYLFRKMRKSLIWRLIPMGSMVFHSLLLLIASVPINLLYCSYILNKGDPSQIFNLPLHYLILAGIQALYIIPCILFLIAHSRFESQILKDRTEYDHW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ64</accession>
    <name>Q5CQ64_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625562.1">
        <property type="nucleotide sequence ID" value="XM_625562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ64"/>
    <dbReference type="GeneID" id="3372514"/>
    <dbReference type="KEGG" id="cpv:cgd5_3980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3980"/>
    <dbReference type="InParanoid" id="Q5CQ64"/>
    <dbReference type="OrthoDB" id="340166at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="578" mass="66181" checksum="934D8E5D78B9C69C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQD8</accession>
    <name>Q5CQD8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PhnP like hydrolase of the metallobetalactamase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87633.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625710.1">
        <property type="nucleotide sequence ID" value="XM_625710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQD8"/>
    <dbReference type="SMR" id="Q5CQD8"/>
    <dbReference type="STRING" id="353152.Q5CQD8"/>
    <dbReference type="GeneID" id="3372676"/>
    <dbReference type="KEGG" id="cpv:cgd4_1130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1130"/>
    <dbReference type="InParanoid" id="Q5CQD8"/>
    <dbReference type="OMA" id="CGPDFRQ"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12706">
        <property type="entry name" value="Lactamase_B_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="1">
        <location>
            <begin position="74"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87633.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="354" mass="40572" checksum="321B1CEA5D3735B7" modified="2005-04-12" version="1">MKLPCGILFVGTGVSSSVPLLHHALNSENYKCLCSYVGKKEGPYDMTKNTRNNVSILVRIPNIKEKENGDDDCYNILIDLGKSFREAAISVFPNYSISKIDSVILTHFHNDAVAGFSSILHFQQKKETLVPIYLNAETLDLVNKRHNKIINNYAFEDNLVNSKDLKRRYELNVFDIYNGKIEKCLNSNKLYNILDSFNKESKFKNNKEFKKIEFSINNIKITAFPMNHGNCICMGYCFHFEEQNVIYISDYTFPMLDSSIEFLNSIKDEKRSTLILDSISYNKISNAHANISQSLKFIQEFSPDYVYFIGMSCSVEHDETNKILNNELINLKNDGKCINTISIELAYDGLFLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQH4</accession>
    <name>Q5CQH4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Conserved protein of possible plant or bacterial origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625674.1">
        <property type="nucleotide sequence ID" value="XM_625674.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQH4"/>
    <dbReference type="FunCoup" id="Q5CQH4">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQH4"/>
    <dbReference type="GeneID" id="3372656"/>
    <dbReference type="KEGG" id="cpv:cgd4_700"/>
    <dbReference type="InParanoid" id="Q5CQH4"/>
    <dbReference type="OMA" id="MQLRYHD"/>
    <dbReference type="OrthoDB" id="10268090at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005811">
        <property type="term" value="C:lipid droplet"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009247">
        <property type="term" value="P:glycolipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051276">
        <property type="entry name" value="Saccharopine_DH-like_oxidrdct"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12286:SF5">
        <property type="entry name" value="SACCHAROPINE DEHYDROGENASE-LIKE OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="429" mass="47154" checksum="7E29671C6EDD4E66" modified="2005-04-12" version="1" fragment="single">SEMSGPQKQYDLFIWGSTGFTGNLICDLLVRTYKPGTTNLNYCFGGRSVDKMEALRKCLIDTLDKETGTSKGEEMISSVPMFVCNNNEEIGKCIANSKVCINVSGPYTECGEIIVSLCCEHYTHYIDLSGEYAWAKKMQKLYGASIASKGLKFATSCGFVSTIVDLGLLHLQNFAAQTSGLPCQEVIHYSQHDGYNQSASYGTVKSVLLTINGPMRNEIKQNDPYGMCNGTLCLSNIAEVTEKNRVACKPIYNSSLQSWTSPNMLSGPYSMFVHFANEEMGYPYGMDFVFSSRSINNSYLSALTGCFKDKIGRFLSERYIISKMVHCGAPYLIGTGPDVSKAKDTVINSTFVGTTMQGKSYKCVVQARDLETYSISAVTALACSFSIIFDYDNLPQTAGFSTPSTLFGVSAIKQCQDLGIQFEVEHLEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQM1</accession>
    <name>Q5CQM1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">MMS19 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625627.1">
        <property type="nucleotide sequence ID" value="XM_625627.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372719"/>
    <dbReference type="KEGG" id="cpv:cgd4_180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_180"/>
    <dbReference type="InParanoid" id="Q5CQM1"/>
    <dbReference type="OMA" id="ICIENEF"/>
    <dbReference type="OrthoDB" id="342900at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029240">
        <property type="entry name" value="MMS19_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14500">
        <property type="entry name" value="MMS19_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MMS19 N-terminal" evidence="1">
        <location>
            <begin position="199"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1474" mass="172230" checksum="8F1877B3312FC306" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQP3</accession>
    <name>Q5CQP3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ank, ankyrin repeats containing protein with 9 transmembrane domains at C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_3840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625959.1">
        <property type="nucleotide sequence ID" value="XM_625959.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372918"/>
    <dbReference type="KEGG" id="cpv:cgd4_3840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3840"/>
    <dbReference type="InParanoid" id="Q5CQP3"/>
    <dbReference type="OMA" id="WRINEVI"/>
    <dbReference type="OrthoDB" id="341259at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1426"/>
            <end position="1444"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1554"/>
            <end position="1573"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1579"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1708"/>
            <end position="1729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1777"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1804"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2061"/>
            <end position="2080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2092"/>
            <end position="2115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="2168"/>
            <end position="2186"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="439"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1118"/>
            <end position="1158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1893"/>
            <end position="1917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1121"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2187" mass="251942" checksum="2D2E6E5AA4A0D35B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQV9</accession>
    <name>Q5CQV9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oocyst wall protein 6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Iowa type II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625893.1">
        <property type="nucleotide sequence ID" value="XM_625893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQV9"/>
    <dbReference type="GeneID" id="3372792"/>
    <dbReference type="KEGG" id="cpv:cgd4_3090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3090"/>
    <dbReference type="InParanoid" id="Q5CQV9"/>
    <dbReference type="OMA" id="DKYSCIC"/>
    <dbReference type="OrthoDB" id="7250310at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254849" evidence="1">
        <location>
            <begin position="23"/>
            <end position="538"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="538" mass="58617" checksum="673E46690D5E7DF9" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQX6</accession>
    <name>Q5CQX6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Aminopeptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd4_2910</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M24B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87928.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625876.1">
        <property type="nucleotide sequence ID" value="XM_625876.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQX6"/>
    <dbReference type="FunCoup" id="Q5CQX6">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQX6"/>
    <dbReference type="GeneID" id="3372972"/>
    <dbReference type="KEGG" id="cpv:cgd4_2910"/>
    <dbReference type="InParanoid" id="Q5CQX6"/>
    <dbReference type="OMA" id="EPGMILS"/>
    <dbReference type="OrthoDB" id="9995434at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01085">
        <property type="entry name" value="APP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.230.10:FF:000007">
        <property type="entry name" value="Xaa-Pro aminopeptidase P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000587">
        <property type="entry name" value="Creatinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033740">
        <property type="entry name" value="Pept_M24B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032416">
        <property type="entry name" value="Peptidase_M24_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050422">
        <property type="entry name" value="X-Pro_aminopeptidase_P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43763:SF6">
        <property type="entry name" value="XAA-PRO AMINOPEPTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01321">
        <property type="entry name" value="Creatinase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16189">
        <property type="entry name" value="Creatinase_N_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16188">
        <property type="entry name" value="Peptidase_M24_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53092">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Creatinase N-terminal" evidence="7">
        <location>
            <begin position="21"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24" evidence="6">
        <location>
            <begin position="377"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M24 C-terminal" evidence="8">
        <location>
            <begin position="617"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008766"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00557"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87928.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="694" mass="79336" checksum="42FE911526707013" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRJ7</accession>
    <name>Q5CRJ7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Mediator complex subunit 6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="primary">MED6</name>
        <name evidence="7" type="ORF">cgd5_2520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626189.1">
        <property type="nucleotide sequence ID" value="XM_626189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRJ7"/>
    <dbReference type="STRING" id="353152.Q5CRJ7"/>
    <dbReference type="GeneID" id="3373205"/>
    <dbReference type="KEGG" id="cpv:cgd5_2520"/>
    <dbReference type="InParanoid" id="Q5CRJ7"/>
    <dbReference type="OMA" id="FEYRITY"/>
    <dbReference type="OrthoDB" id="344220at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.580">
        <property type="entry name" value="Mediator complex, subunit Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007018">
        <property type="entry name" value="Mediator_Med6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038566">
        <property type="entry name" value="Mediator_Med6_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13104">
        <property type="entry name" value="MED-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04934">
        <property type="entry name" value="Med6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007526"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="199" mass="23114" checksum="FDD16270659BEB36" modified="2005-04-12" version="1" fragment="single">IFKENLGSTLSKFLVRIIHHFSGLYYSLLRSLCILAKKFEFILFHIFSASEGFEYRITYINEEGLGNVPQPPGSTWNTPNQFGIFIIQKFFIEFQREIPLNIYYILSGTIYEAPTLSNVFLHRTAEAFLSMEKIFDTLSEMSRFSLYEGYTWDNLEVTSKINSDIENADSKNTNSGEEESLGTFLLFLFCVFVKLNYFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRM9</accession>
    <name>Q5CRM9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nuc1p like endonuclease G</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_2190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA/RNA non-specific endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626157.1">
        <property type="nucleotide sequence ID" value="XM_626157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRM9"/>
    <dbReference type="STRING" id="353152.Q5CRM9"/>
    <dbReference type="GeneID" id="3373110"/>
    <dbReference type="KEGG" id="cpv:cgd5_2190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2190"/>
    <dbReference type="InParanoid" id="Q5CRM9"/>
    <dbReference type="OMA" id="MANCPAT"/>
    <dbReference type="OrthoDB" id="336129at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.570.10">
        <property type="entry name" value="Extracellular Endonuclease, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044929">
        <property type="entry name" value="DNA/RNA_non-sp_Endonuclease_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001604">
        <property type="entry name" value="Endo_G_ENPP1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020821">
        <property type="entry name" value="ENPP1-3/EXOG-like_nuc-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044925">
        <property type="entry name" value="His-Me_finger_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040255">
        <property type="entry name" value="Non-specific_endonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966:SF5">
        <property type="entry name" value="ENDONUCLEASE G, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13966">
        <property type="entry name" value="ENDONUCLEASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01223">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00892">
        <property type="entry name" value="Endonuclease_NS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00477">
        <property type="entry name" value="NUC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54060">
        <property type="entry name" value="His-Me finger endonucleases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254885" evidence="4">
        <location>
            <begin position="21"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="domain" description="DNA/RNA non-specific endonuclease/pyrophosphatase/phosphodiesterase" evidence="6">
        <location>
            <begin position="85"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="domain" description="ENPP1-3/EXOG-like endonuclease/phosphodiesterase" evidence="5">
        <location>
            <begin position="86"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="149"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR640255-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="472" mass="53876" checksum="C62FFACBE9A3098A" modified="2005-04-12" version="1">MTMKSTVNLMLGVAIGTAIGYKLYPNIEGNNLKHNLLKNMDIQHVNIGQKYFSKKFNKYSDKIVKSVTGGFYPSVKLPSTENLILRESYLSSVSFRDKIPNWVAEKISNETCSGKANRADCVFQVDPDVPLIWSAENKDYFASGYSRGHMAAAGQHKNTETAQSDTFYLSGNILPQDLSNNGADWYRLELISRELTNYYQDVYVVSGPLFAPNYMRSKDFKKLAQNLESIKKEDPPKDALGQICVIHKKDVLDKARELGDEKKMDPNLIVKSDLKDTPVNTVTYEVIGDKLVSAPPHLFKVILAVNPKKEKDIDVPPVAFGSFIMKNEPESKRHLITEYMVPLKSIEISTGLDFSGLKEFTINYLKANISRKDFKKLLNYEDLDEFENMYSICNVKDTLRHGKSAQSICNDEDSERVKSWRYLGYIKLSKTKKELEDIWNTIKSNGYDKENFFLRKEYVNKCKSLGIEPEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRR6</accession>
    <name>Q5CRR6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">H/ACA ribonucleoprotein complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd5_1760</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the GAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626120.1">
        <property type="nucleotide sequence ID" value="XM_626120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRR6"/>
    <dbReference type="STRING" id="353152.Q5CRR6"/>
    <dbReference type="GeneID" id="3373007"/>
    <dbReference type="KEGG" id="cpv:cgd5_1760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1760"/>
    <dbReference type="InParanoid" id="Q5CRR6"/>
    <dbReference type="OMA" id="KPQDGIV"/>
    <dbReference type="OrthoDB" id="2187159at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034513">
        <property type="term" value="F:box H/ACA snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000454">
        <property type="term" value="P:snoRNA guided rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.230:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.230">
        <property type="entry name" value="Probable tRNA pseudouridine synthase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038664">
        <property type="entry name" value="Gar1/Naf1_Cbf5-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007504">
        <property type="entry name" value="H/ACA_rnp_Gar1/Naf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237:SF6">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23237">
        <property type="entry name" value="NUCLEOLAR PROTEIN FAMILY A MEMBER 1 SNORNP PROTEIN GAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04410">
        <property type="entry name" value="Gar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="123"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="27"/>
            <end position="39"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="182" mass="19526" checksum="606A20F12CF820D4" modified="2005-04-12" version="1">MSARGSRGNFRGGRGSSRGKGGVPSNGRPSFSGPPSSITELGEVLHSSEHELVCKSFLNDQVPYFNGRIFLENKEEIGKVDEILGPINTYFFSIKMNNGVKAESFVTGTKIFIDPQQLLPMSRFLPKPSTQKTTKKTGEAAIGKKRGFNGSPGRGGQSRGVRGRGFARGASPRGFRGRGTSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRX4</accession>
    <name>Q5CRX4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C2H2 finger domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_1110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626062.1">
        <property type="nucleotide sequence ID" value="XM_626062.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRX4"/>
    <dbReference type="GeneID" id="3373072"/>
    <dbReference type="KEGG" id="cpv:cgd5_1110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1110"/>
    <dbReference type="InParanoid" id="Q5CRX4"/>
    <dbReference type="OMA" id="HMSEANI"/>
    <dbReference type="OrthoDB" id="343266at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="3">
        <location>
            <begin position="196"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="231"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="234"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="251" mass="28543" checksum="25DC2A6972482745" modified="2005-04-12" version="1">MPYSNKSFFSHEQVENIIQENKQLIYGINSFKKNDRHEEFLRVLLSRLQKNLFLLAHLSNQPKAPNHLTVNDLLRPVFSCDYSSENKRATPQQTISNRAPNIALNSPILSSNTSQPIYFEANNVDFRINDQKISDQQNLQSCENPNIISNPQLSKLCYEPIASISPEFDPQNGIGISIGNSSSSPNYIQTQNNEHFICRYCQRKCRNQSGLTQHTMKVHPDAPEVQHLLKQAQSRSSPNPLSIINISSSTY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS59</accession>
    <name>Q5CS59_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine(9)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88191.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625977.1">
        <property type="nucleotide sequence ID" value="XM_625977.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS59"/>
    <dbReference type="FunCoup" id="Q5CS59">
        <property type="interactions" value="179"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS59"/>
    <dbReference type="GeneID" id="3373198"/>
    <dbReference type="KEGG" id="cpv:cgd5_120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_120"/>
    <dbReference type="InParanoid" id="Q5CS59"/>
    <dbReference type="OMA" id="FKKNDGW"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="7">
        <location>
            <begin position="98"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88191.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="343" mass="40386" checksum="7659D4D85D69B804" modified="2005-04-12" version="1">MISNPLLDLNLSNNDIKKSESSNKRLTKSQKKMIARENRKLKLKSQRVEERKRQRSQASSQRKEFLNSMTEDERRSYILRERFIEEHKRFFLSKFSISHFSDYKFEKTGNPHICFNFSFENKMTEKEMNSLIRQISLANSYMMRSLKIVDTENPDSDAMKTLLELGPNSETSKSYYNRFNWKGWVDFHISSIKLNDTFHQIGIEKYSMNKWFMKLHEKPFWEVFPLSQIVVLSPDSSEELEEFEPDKVYIIGGLVDRTVTKYESLNQALEKKCVCKKLPVKSLISGRANCILNVNTVVEILVNRYHQNDWKTSISQAIPVRKAQNHSRRAVKKQKLLNSSTNC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSF0</accession>
    <name>Q5CSF0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ER lumen protein retaining receptor 1 KDEL recpetor 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd1_3010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628117.1">
        <property type="nucleotide sequence ID" value="XM_628117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSF0"/>
    <dbReference type="STRING" id="353152.Q5CSF0"/>
    <dbReference type="GeneID" id="3371712"/>
    <dbReference type="KEGG" id="cpv:cgd1_3010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3010"/>
    <dbReference type="InParanoid" id="Q5CSF0"/>
    <dbReference type="OMA" id="YILLPCI"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="86"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="115"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="149"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="178"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="210"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="284" mass="32576" checksum="F099F22FDE80B8CF" modified="2005-04-12" version="1">MEVVNSAVTIISDPEKCRTWVSQHKSSVKAYISLAIFCVIVFFFLSDGDFSFLLTLSSLTSAFSFAMVCLKIEITKSCAGVSLRMMEAYVILIFARLCSIIPFEGYLPYDRSGDWLYQTLEASCMIIAGTIVYLCRYRYKETYDPNSDEFNSMYLIIPAFLMALVFHPSLNSWMPADIAWTFALYLESVVVLPQLFMFQKERKVVPFTSHFLAMQAVSKVLAFIFWISSYTELNDPSKVLKKHVGYWVIIMQIVQLALMGDFVYHYARCITRGVPVQFILMENV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSF5</accession>
    <name>Q5CSF5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd1_2960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628112.1">
        <property type="nucleotide sequence ID" value="XM_628112.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSF5"/>
    <dbReference type="FunCoup" id="Q5CSF5">
        <property type="interactions" value="121"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSF5"/>
    <dbReference type="GeneID" id="3371345"/>
    <dbReference type="KEGG" id="cpv:cgd1_2960"/>
    <dbReference type="InParanoid" id="Q5CSF5"/>
    <dbReference type="OMA" id="NHKGPNG"/>
    <dbReference type="OrthoDB" id="2649at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050684">
        <property type="term" value="P:regulation of mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000275">
        <property type="entry name" value="SRSF protein kinase 2 isoform X3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051334">
        <property type="entry name" value="SRPK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47634:SF9">
        <property type="entry name" value="PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="81"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="266"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="266"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="294"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="331"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="370"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="765" mass="87854" checksum="3955ECD6A8FF16DA" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSG8</accession>
    <name>Q5CSG8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Obg-like ATPase homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_2760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628099.1">
        <property type="nucleotide sequence ID" value="XM_628099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSG8"/>
    <dbReference type="FunCoup" id="Q5CSG8">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSG8"/>
    <dbReference type="GeneID" id="3371349"/>
    <dbReference type="KEGG" id="cpv:cgd1_2760"/>
    <dbReference type="InParanoid" id="Q5CSG8"/>
    <dbReference type="OMA" id="VLRCFDN"/>
    <dbReference type="OrthoDB" id="424823at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04867">
        <property type="entry name" value="TGS_YchF_OLA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01900">
        <property type="entry name" value="YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.300:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.30:FF:000001">
        <property type="entry name" value="Ribosome-binding ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.300">
        <property type="entry name" value="TGS-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00944">
        <property type="entry name" value="YchF_OLA1_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004396">
        <property type="entry name" value="ATPase_YchF/OLA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012676">
        <property type="entry name" value="TGS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023192">
        <property type="entry name" value="TGS-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013029">
        <property type="entry name" value="YchF_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041706">
        <property type="entry name" value="YchF_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00092">
        <property type="entry name" value="redox-regulated ATPase YchF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305">
        <property type="entry name" value="OBG GTPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23305:SF11">
        <property type="entry name" value="OBG-LIKE ATPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06071">
        <property type="entry name" value="YchF-GTPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006641">
        <property type="entry name" value="CHP00092"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81271">
        <property type="entry name" value="TGS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OBG-type G" evidence="4">
        <location>
            <begin position="23"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="TGS" evidence="5">
        <location>
            <begin position="307"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00068719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="398" mass="44678" checksum="235B4B1EF73DDF1D" modified="2005-04-12" version="1" fragment="single">KMPPKKNEQKEVKVLLGRPRGNLKMGLVGLPNVGKSTTFNLLCKQAVPAENFPFCTIEPHEARMNVPDDRFRALCKHFSPKSEVPATLTIFDIAGLVPGAHKGEGLGNAFLSNIQAVDGIYHVVRAFESDEIVHTEGEVNPVKDLETISNELRMKDLERVDKLISELNRLTKNGTDRTKKEQVAALQILKDVYAHLEAGNWISSKYDWKSSEVELLNEHQFLTAKPVVYLVNLSEKDYIRQKNKFLPKIAEWVKEHIDGVIIPYSAEFEAALAELHTEEEKMAYIKEKGASKSMIDKIINTGYSALNLLHYFTAGEDEVKCWTIRSGTKAPQAAGIIHTDFERGFICAEVYKFTDLMELGSEAAIKAAGKYLQKGKDYVVEDGDIIFFKFNVTNSGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSJ2</accession>
    <name>Q5CSJ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628075.1">
        <property type="nucleotide sequence ID" value="XM_628075.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSJ2"/>
    <dbReference type="GeneID" id="3371701"/>
    <dbReference type="KEGG" id="cpv:cgd1_2460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2460"/>
    <dbReference type="InParanoid" id="Q5CSJ2"/>
    <dbReference type="OrthoDB" id="340849at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="190" mass="20988" checksum="D38ED724F762C9C3" modified="2005-04-12" version="1">MSNKSSERKTFGGYYNSHNNRRKKRDLVVSNCSNTNGSSSTAYNKYYNKANRDDPGALILKLLHSGRNIETASVVPQSNSYIRPQSRTKNCESVEPNFKMQSEEPINVNSENPNATSVNLFATPPPNRKGRYSVVSSYGTNNPKFVNYSNSGGNKSLQSSSSNPTNFALPMYMRSPNPESIPMPCGFPIG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSW9</accession>
    <name>Q5CSW9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627948.1">
        <property type="nucleotide sequence ID" value="XM_627948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSW9"/>
    <dbReference type="GeneID" id="3371554"/>
    <dbReference type="KEGG" id="cpv:cgd1_1030"/>
    <dbReference type="InParanoid" id="Q5CSW9"/>
    <dbReference type="OrthoDB" id="342618at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="173" mass="19395" checksum="5D1EFE08A472ECD3" modified="2005-04-12" version="1">MCLEGKNSTNSENQPKKFTLNDEKLLNYLSERVIKTAKISTERGLILNDYYSEQGTNSPHTSLSQVPAQEIACDMLFACIPKSLTNVGERLKRRFGEYKTTNDSGNTDKNNASLNKNPKNQYIGVKRGINKRAPPIITKSTPSKRAPPHKSLKLNVNNDVSNGNILEFLKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSX0</accession>
    <name>Q5CSX0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rnh202 triple barrel domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627947.1">
        <property type="nucleotide sequence ID" value="XM_627947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSX0"/>
    <dbReference type="GeneID" id="3371597"/>
    <dbReference type="KEGG" id="cpv:cgd1_1020"/>
    <dbReference type="InParanoid" id="Q5CSX0"/>
    <dbReference type="OrthoDB" id="342618at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041195">
        <property type="entry name" value="Rnh202_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17745">
        <property type="entry name" value="Ydr279_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rnh202 triple barrel" evidence="1">
        <location>
            <begin position="18"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="163" mass="18748" checksum="78A891BEEFBE9499" modified="2005-04-12" version="1">MEYKNKKFVVFPDTNTGLERNLTIITLPHPSVSTLCEYLFDTVNNEVYEIFELSERSSGIKPSAFFGNDCISKLELCGAVNVDTFFFLISALVFARNKKYVNKELSQVVIYYISNLKLELEQSDFDLFDEVKDGILELFQKFLLDTKLIEKIEKVCDISLGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSX6</accession>
    <name>Q5CSX6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_950</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627941.1">
        <property type="nucleotide sequence ID" value="XM_627941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSX6"/>
    <dbReference type="SMR" id="Q5CSX6"/>
    <dbReference type="GeneID" id="3371557"/>
    <dbReference type="KEGG" id="cpv:cgd1_950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_950"/>
    <dbReference type="InParanoid" id="Q5CSX6"/>
    <dbReference type="OrthoDB" id="341897at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254214" evidence="3">
        <location>
            <begin position="30"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="448"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="305"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="310"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="481" mass="54124" checksum="1F378C1398E74B00" modified="2005-04-12" version="1">MASIKIFKSLPFNFLLLFTLLVFSIGVVSVKSNDNSEKLPVFALVDIFHVPPESRQKCSTILGWLATKYPNNYVLMSVRNIIYQLALPHSMLQENAEKELIAAMDSLQGTMSNVSGLEPGTYISILTCSVDNKGRTILQKMVEHGLVQALSHTLSQKFWVGAKLNKLLDTEGNNLAHLAAMSENDELVHYVLGIMFKSNIVAEMLESLNSNGQKPIDIAIFHRDQQTVDTMKNFFRVTTLAEREGFVDGVEVIEDSVALAEKEAENKRFKEFIEKEEDAASKITNAEITRDIEYAKQDNYKESINDDISDSQSQSFESSAAEDSMNSSQLTQSLEDEFSIKPRLKDQDILQNENNQQEQTFSDENIYDEQMEDSIINGNQRFSAINKIENTEKGDEPRETELNFSSLRGAVENNMDQETQHHHYQDDQEEIKQVNKEPQSKWNATAKAIVGASILVGTSILAATVVFIVCKGYGNKEENSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSY0</accession>
    <name>Q5CSY0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ZnF A20 and Znf AN1 domains, involved in signaling</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627937.1">
        <property type="nucleotide sequence ID" value="XM_627937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSY0"/>
    <dbReference type="FunCoup" id="Q5CSY0">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSY0"/>
    <dbReference type="GeneID" id="3371370"/>
    <dbReference type="KEGG" id="cpv:cgd1_910"/>
    <dbReference type="InParanoid" id="Q5CSY0"/>
    <dbReference type="OMA" id="VLCENNC"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050652">
        <property type="entry name" value="AN1_A20_ZnFinger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002653">
        <property type="entry name" value="Znf_A20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634:SF149">
        <property type="entry name" value="AN1-TYPE DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10634">
        <property type="entry name" value="AN1-TYPE ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01754">
        <property type="entry name" value="zf-A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00259">
        <property type="entry name" value="ZnF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51036">
        <property type="entry name" value="ZF_A20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51039">
        <property type="entry name" value="ZF_AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="A20-type" evidence="6">
        <location>
            <begin position="21"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="7">
        <location>
            <begin position="134"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="105"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="57"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00449"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="199" mass="21878" checksum="B52682F9880C1A91" modified="2005-04-12" version="1" fragment="single">IQKLIIFIMDSNTPPVSSSPAHSPSLCLNNCGFYGNPTTNNLCSKCYKDSISGNSVSNQSSVSHPQSSDSVGPSKDSECGFLETSKEFKQESSSPTLIEQEITSIETTKEKDSQDLTTEPASSSASLSSPTEKPSIPGRCYHCNKKVGIYGFNCRCGFNFCSTHRYADAHDCTFDYKTFEREQLRKTNQAVIADKIQRI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT06</accession>
    <name>Q5CT06_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted secreted protein, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627911.1">
        <property type="nucleotide sequence ID" value="XM_627911.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT06"/>
    <dbReference type="GeneID" id="3371547"/>
    <dbReference type="KEGG" id="cpv:cgd1_550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_550"/>
    <dbReference type="InParanoid" id="Q5CT06"/>
    <dbReference type="OMA" id="NITIRIC"/>
    <dbReference type="OrthoDB" id="342760at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2995" mass="347001" checksum="5D4464C069D333D6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2009-11-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT19</accession>
    <name>COQ4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial</fullName>
        </recommendedName>
        <alternativeName>
            <fullName>4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase</fullName>
            <ecNumber evidence="1">4.1.1.130</ecNumber>
        </alternativeName>
        <alternativeName>
            <fullName evidence="1">Coenzyme Q biosynthesis protein 4 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name type="ORF">cgd1_380</name>
    </gene>
    <organism>
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoic acid into 2-methoxy-6-(all-trans-polyprenyl)phenol during ubiquinone biosynthesis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a 4-hydroxy-3-methoxy-5-(all-trans-polyprenyl)benzoate + H(+) = a 2-methoxy-6-(all-trans-polyprenyl)phenol + CO2</text>
            <dbReference type="Rhea" id="RHEA:81179"/>
            <dbReference type="Rhea" id="RHEA-COMP:9551"/>
            <dbReference type="Rhea" id="RHEA-COMP:10931"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:62731"/>
            <dbReference type="ChEBI" id="CHEBI:84443"/>
            <dbReference type="EC" id="4.1.1.130"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="1">Cofactor biosynthesis; ubiquinone biosynthesis.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of a multi-subunit COQ enzyme complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="miscellaneous">
        <text evidence="1">This protein may be expected to contain an N-terminal transit peptide but none has been predicted.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ4 family.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.130" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627898.1">
        <property type="nucleotide sequence ID" value="XM_627898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT19"/>
    <dbReference type="SMR" id="Q5CT19"/>
    <dbReference type="STRING" id="353152.Q5CT19"/>
    <dbReference type="EnsemblProtists" id="EAK88604">
        <property type="protein sequence ID" value="EAK88604"/>
        <property type="gene ID" value="cgd1_380"/>
    </dbReference>
    <dbReference type="GeneID" id="3371528"/>
    <dbReference type="KEGG" id="cpv:cgd1_380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_380"/>
    <dbReference type="InParanoid" id="Q5CT19"/>
    <dbReference type="OMA" id="YYERHFH"/>
    <dbReference type="OrthoDB" id="4249at2759"/>
    <dbReference type="UniPathway" id="UPA00232"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031314">
        <property type="term" value="C:extrinsic component of mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120539">
        <property type="term" value="F:4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03111">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007715">
        <property type="entry name" value="Coq4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027540">
        <property type="entry name" value="Coq4_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12922:SF7">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS PROTEIN COQ4 HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05019">
        <property type="entry name" value="Coq4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword id="KW-0456">Lyase</keyword>
    <keyword id="KW-0472">Membrane</keyword>
    <keyword id="KW-0479">Metal-binding</keyword>
    <keyword id="KW-0496">Mitochondrion</keyword>
    <keyword id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0831">Ubiquinone biosynthesis</keyword>
    <keyword id="KW-0862">Zinc</keyword>
    <feature type="chain" id="PRO_0000388075" description="Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial">
        <location>
            <begin position="1"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="151"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="154"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <position position="166"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000255" key="1">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03111"/>
        </source>
    </evidence>
    <sequence length="305" mass="35648" checksum="5B10196B27C666DD" modified="2005-04-12" version="1">MNKFTNLLIKRTASSLKGGDFRELFRKNYIPITQFEKVLLSVTSCVEGLKNPTDSNSVACITELTSNRALRRLQILMNSTPDGRRIIKNRPLIDSSKYSIKDLMAFPDDSLGRRYGEFLTTYNLEINRDPVRYVNSEDLAYVLTRFRQIHDILHTAFELNITVESEVTLKLFEFLHAGIPFGAIGAFMGLFITPILKVRPKEIFENHNKTHVYPSKPIQIHQDCDKYLNSLEITKKEILYPKRIVIKELIPWIYKAEKKMRHNIYTIMVEDWFPRPIADFQNYLNISPPPKQLQKYTRIKPMPFC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT68</accession>
    <name>Q5CT68_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_4220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626601.1">
        <property type="nucleotide sequence ID" value="XM_626601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT68"/>
    <dbReference type="GeneID" id="3373481"/>
    <dbReference type="KEGG" id="cpv:cgd2_4220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4220"/>
    <dbReference type="InParanoid" id="Q5CT68"/>
    <dbReference type="OMA" id="FLKCKIG"/>
    <dbReference type="OrthoDB" id="341899at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="443"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="134"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="936" mass="108385" checksum="780543E747A89C56" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT91</accession>
    <name>Q5CT91_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit H</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_3960</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase H subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88638.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626578.1">
        <property type="nucleotide sequence ID" value="XM_626578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT91"/>
    <dbReference type="FunCoup" id="Q5CT91">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT91"/>
    <dbReference type="GeneID" id="3373396"/>
    <dbReference type="KEGG" id="cpv:cgd2_3960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3960"/>
    <dbReference type="InParanoid" id="Q5CT91"/>
    <dbReference type="OMA" id="MKLCTHN"/>
    <dbReference type="OrthoDB" id="10263554at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.150">
        <property type="entry name" value="V-type ATPase, subunit H, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004908">
        <property type="entry name" value="ATPase_V1-cplx_hsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011987">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038497">
        <property type="entry name" value="ATPase_V1-cplx_hsu_C_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10698:SF0">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11698">
        <property type="entry name" value="V-ATPase_H_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03224">
        <property type="entry name" value="V-ATPase_H_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF032184">
        <property type="entry name" value="ATPase_V1_H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase V1 complex subunit H C-terminal" evidence="7">
        <location>
            <begin position="360"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="176"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="178"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR032184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF11698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88638.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="493" mass="55670" checksum="9E207E34B089C8E3" modified="2005-04-12" version="1">MRSTEQVKLIGKLASSEHTSTAEKRSRILSHAPHWKKYELAGALPVGSSVKLMALHNQSLLVRSQLLSSDKQLRQLVLNCLGITPDLEPAQYILTMIYELVRDDAGQYHGFVETTKGIPIFEKFMQFLERPKVDSYLSDKLLFFLSGLISHSNDGAYTKENITELIDHLFKTPENRRSLSGASQDDSSSSSIASSSNVNRMESSYSTLNGGYCSVIGALDVLGNLVKVDAYRMLVLSHPNVVEFISSNLSSSSPTSHIYKACVIVWLLSFNEETVPILVSRDLIRQIANTIIDCRSEKVVRVTLNLLKNVMNNDAAIESIIDLGLLQYLTILEYEKWLDPEIYEEIRQGQIMIDQKLKQFSNFDRYCIELEKKKFKWSFLHTEKFWLENVMNFESDEFAAIKKLAHLLKTSDDPVTLAVACFDIGEFARLYPMGKQILGKLNVKEVLMTLMTSPNREISKEALLSIQKLMLNKWNRANIGSNSGSNTTTTVKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTF5</accession>
    <name>Q5CTF5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">ARF GAP-like zinc finger-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_3240</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626514.1">
        <property type="nucleotide sequence ID" value="XM_626514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTF5"/>
    <dbReference type="FunCoup" id="Q5CTF5">
        <property type="interactions" value="15"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTF5"/>
    <dbReference type="GeneID" id="3373700"/>
    <dbReference type="KEGG" id="cpv:cgd2_3240"/>
    <dbReference type="InParanoid" id="Q5CTF5"/>
    <dbReference type="OMA" id="PWWEKGQ"/>
    <dbReference type="OrthoDB" id="983479at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08830">
        <property type="entry name" value="ArfGap_ArfGap1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF18">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE-ACTIVATING PROTEIN GCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="7">
        <location>
            <begin position="9"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="146"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="313"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="329"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="358"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="417" mass="45478" checksum="4A5805C3B238D0D8" modified="2005-04-12" version="1" fragment="single">IEIMDNKTQQFFKSIKEKDPLNNKCIDCGAPHPQWASVSHGCLMCLTCSGVHRGLGVHISFIRSITMDSWTPKQMKAMELGGNTRLTEIFSEYGLNGCDIKKKYNSQIAAYYRGMLKDLCEGNTPGPKPSKSIGCLEYVPESNNKNNNVGSNNGFSPMRTGTSFSSSNSFGNNPSDDKYANLFDRNIGSKGFGGILDSLSSFSMKVISNTKSYAESTINHVNERGILESAIDSVKAGGTYIEEAGRAVVEKVQDEKFWSNTATTMQNSAQWVNNTIQSGISGVNEVIQTAIDPSNFNDPLNNIFGDDINEAETDRSGQIDPQKSLDSINSNSFNSSNSNFTRTIGRKPSPPSESLATNMNSNSKASPSNKAPQSVISSSNSNVNIVQSDVKNINLWESDLGDDWEPKDFKKGNTKKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTK4</accession>
    <name>Q5CTK4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_2630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626465.1">
        <property type="nucleotide sequence ID" value="XM_626465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTK4"/>
    <dbReference type="GeneID" id="3373637"/>
    <dbReference type="KEGG" id="cpv:cgd2_2630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2630"/>
    <dbReference type="InParanoid" id="Q5CTK4"/>
    <dbReference type="OrthoDB" id="340715at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="303"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="347"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="513"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="620"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="656" mass="74018" checksum="39089CBBBE6FFAE3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTN4</accession>
    <name>Q5CTN4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_2310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626435.1">
        <property type="nucleotide sequence ID" value="XM_626435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTN4"/>
    <dbReference type="STRING" id="353152.Q5CTN4"/>
    <dbReference type="GeneID" id="3373503"/>
    <dbReference type="KEGG" id="cpv:cgd2_2310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2310"/>
    <dbReference type="InParanoid" id="Q5CTN4"/>
    <dbReference type="OMA" id="MTIANRN"/>
    <dbReference type="OrthoDB" id="10252354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050660">
        <property type="entry name" value="NEK_Ser/Thr_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE NEK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43671:SF13">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="6">
        <location>
            <begin position="260"/>
            <end position="544"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="544" mass="63670" checksum="A5A83DAE7C9DFA8C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTP7</accession>
    <name>Q5CTP7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar GTP-binding protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_2170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
            <location evidence="1 5">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626422.1">
        <property type="nucleotide sequence ID" value="XM_626422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTP7"/>
    <dbReference type="FunCoup" id="Q5CTP7">
        <property type="interactions" value="172"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTP7"/>
    <dbReference type="GeneID" id="3373521"/>
    <dbReference type="KEGG" id="cpv:cgd2_2170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2170"/>
    <dbReference type="InParanoid" id="Q5CTP7"/>
    <dbReference type="OMA" id="RTQGFNH"/>
    <dbReference type="OrthoDB" id="444945at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01858">
        <property type="entry name" value="NGP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000559">
        <property type="entry name" value="Nuclear/nucleolar GTPase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1580.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024929">
        <property type="entry name" value="GNL2_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023179">
        <property type="entry name" value="GTP-bd_ortho_bundle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012971">
        <property type="entry name" value="NOG2_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050755">
        <property type="entry name" value="TRAFAC_YlqF/YawG_RiboMat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089">
        <property type="entry name" value="GTP-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11089:SF9">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08153">
        <property type="entry name" value="NGP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="234"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="23"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="26"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="39"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="562" mass="65075" checksum="B8988669397A2CB4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTQ4</accession>
    <name>Q5CTQ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_2100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626415.1">
        <property type="nucleotide sequence ID" value="XM_626415.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTQ4"/>
    <dbReference type="GeneID" id="3373527"/>
    <dbReference type="KEGG" id="cpv:cgd2_2100"/>
    <dbReference type="InParanoid" id="Q5CTQ4"/>
    <dbReference type="OMA" id="EIDHMSK"/>
    <dbReference type="OrthoDB" id="340807at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254957" evidence="2">
        <location>
            <begin position="26"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="25"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="178" mass="19898" checksum="E3F4F09F4E75B0AD" modified="2005-04-12" version="1">MKGFIGIQFIAYLFLFFYCLNVARCDNKINNLLELRQSILQHEKELENLHGATSNLVGEAADVLSFSKKRPIFSELNNFSTPGAPTTTIKMTLKFPNTAPVSINQGKLREEIRNTATGNGDAVPSINPIPLVVIRPDALTNLLSSLSATVHQRKKIECKFIKNLIFILIIFSEKNYST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTS2</accession>
    <name>Q5CTS2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PDI like thioredoxin domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_1780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626397.1">
        <property type="nucleotide sequence ID" value="XM_626397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTS2"/>
    <dbReference type="STRING" id="353152.Q5CTS2"/>
    <dbReference type="GeneID" id="3373741"/>
    <dbReference type="KEGG" id="cpv:cgd2_1780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1780"/>
    <dbReference type="InParanoid" id="Q5CTS2"/>
    <dbReference type="OMA" id="FCYINNE"/>
    <dbReference type="OrthoDB" id="427280at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052842">
        <property type="entry name" value="ER_Co-chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45184">
        <property type="entry name" value="DNAJ PROTEIN ERDJ3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45184:SF1">
        <property type="entry name" value="DNAJ PROTEIN ERDJ3A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253843" evidence="1">
        <location>
            <begin position="23"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="438" mass="49735" checksum="4745F93ECB31B2A1" modified="2005-04-12" version="1">MILLYVLSFLFSTFVSFPCASSKVILDPLQHDVQILTAPNFESLLSKYRKSGVTSVFFYNGDDKVAVSELLGWYNDAARELKGMAKVAAINCKEFKQFCSKIGNSGKIIIYPVIPIPTFEFNGEKSVRNLKNQLLRYIPRDNVSVIGVPNQESSKVIKIEDFLTRHISVPKVLVFSEKEIPPTIIHSLANEFNKKLLFGFIPNCKKNDVSIGITKKFQISSFPTIMVYKTASKLPEFYKGEIKFLPLFEFLNVYAETFVMGGGFSDNESQDSGSKPWLLQRIPELTGLSYNDVCGKHKNLCFIYLKNGEISLEEQSMLEELQDLFTPHIAGRGTNFKWMWMDISMEDEFMKLFNDDGNKIALPSAVVLGTSKRLKFTVLPRNIEGELQTANKDTIKDFLDKVIGGDARFTNIKGQKLPKFIERVQNKNTKLEKSRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTX3</accession>
    <name>Q5CTX3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">2'-phosphotransferase</fullName>
            <ecNumber evidence="3">2.7.1.160</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_1210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>2'-phospho-[ligated tRNA] + NAD(+) = mature tRNA + ADP-alpha-D-ribose 1'',2''-cyclic phosphate + nicotinamide</text>
            <dbReference type="Rhea" id="RHEA:23324"/>
            <dbReference type="Rhea" id="RHEA-COMP:11106"/>
            <dbReference type="Rhea" id="RHEA-COMP:11107"/>
            <dbReference type="ChEBI" id="CHEBI:17154"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:76596"/>
            <dbReference type="ChEBI" id="CHEBI:82883"/>
            <dbReference type="ChEBI" id="CHEBI:85027"/>
            <dbReference type="EC" id="2.7.1.160"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the KptA/TPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.160" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626346.1">
        <property type="nucleotide sequence ID" value="XM_626346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTX3"/>
    <dbReference type="STRING" id="353152.Q5CTX3"/>
    <dbReference type="GeneID" id="3373584"/>
    <dbReference type="KEGG" id="cpv:cgd2_1210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1210"/>
    <dbReference type="InParanoid" id="Q5CTX3"/>
    <dbReference type="OMA" id="RHGASQM"/>
    <dbReference type="OrthoDB" id="419694at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000215">
        <property type="term" value="F:tRNA 2'-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.170.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.970">
        <property type="entry name" value="RNA 2'-phosphotransferase, Tpt1/KptA family, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002745">
        <property type="entry name" value="Ptrans_KptA/Tpt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042081">
        <property type="entry name" value="RNA_2'-PTrans_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042080">
        <property type="entry name" value="RNA_2'-PTrans_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684">
        <property type="entry name" value="PUTATIVE PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12684:SF2">
        <property type="entry name" value="TRNA 2'-PHOSPHOTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01885">
        <property type="entry name" value="PTS_2-RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56399">
        <property type="entry name" value="ADP-ribosylation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="254" mass="29132" checksum="0DB1A2BF0999CA12" modified="2005-04-12" version="1">MTKTSNVLISKKLTWLLRHGDPAKTGLNMRNDGYVEVNEILKQTCISLEKLHYIVENDPKGRFRIIDENGKNLIRANQGHSLSFIEDEKLLARFEIDNNSEFIQRIIIHGTYLDKWKNIKINGLSRMSRSHIHFVSATNFKLESIKQGSKISEDMCIDQIVREMCNYKCTAGIRPNCEVLVFIDVVNCVTNSAEYKFYLSDNGVVLTRGNSQGIIDSTMFLFCIDIKNGEILLNNINNEHKITEIVRFIVNSAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUE0</accession>
    <name>Q5CUE0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ser/thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_3230</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626874.1">
        <property type="nucleotide sequence ID" value="XM_626874.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUE0"/>
    <dbReference type="GeneID" id="3373874"/>
    <dbReference type="KEGG" id="cpv:cgd3_3230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3230"/>
    <dbReference type="InParanoid" id="Q5CUE0"/>
    <dbReference type="OMA" id="NICKAER"/>
    <dbReference type="OrthoDB" id="341578at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13996">
        <property type="entry name" value="STKc_EIF2AK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF178">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="284"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="802"/>
            <end position="828"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="805"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="314"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1548" mass="178110" checksum="414C21A843FFDFF3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUG7</accession>
    <name>Q5CUG7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Prp8. JAB/PAD domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd3_2890</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626847.1">
        <property type="nucleotide sequence ID" value="XM_626847.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CUG7">
        <property type="interactions" value="612"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUG7"/>
    <dbReference type="GeneID" id="3374104"/>
    <dbReference type="KEGG" id="cpv:cgd3_2890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2890"/>
    <dbReference type="InParanoid" id="Q5CUG7"/>
    <dbReference type="OMA" id="ANKWNTS"/>
    <dbReference type="OrthoDB" id="1931567at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097157">
        <property type="term" value="F:pre-mRNA intronic binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030619">
        <property type="term" value="F:U1 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030620">
        <property type="term" value="F:U2 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030623">
        <property type="term" value="F:U5 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000393">
        <property type="term" value="P:spliceosomal conformational changes to generate catalytic conformation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000244">
        <property type="term" value="P:spliceosomal tri-snRNP complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08056">
        <property type="entry name" value="MPN_PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd13838">
        <property type="entry name" value="RNase_H_like_Prp8_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.80.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.230:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.140.10:FF:000002">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1570.40:FF:000001">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.80.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1570.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.140.10">
        <property type="entry name" value="Cytidine Deaminase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.43.40">
        <property type="entry name" value="Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012591">
        <property type="entry name" value="PRO8NT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012592">
        <property type="entry name" value="PROCN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012984">
        <property type="entry name" value="PROCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027652">
        <property type="entry name" value="PRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021983">
        <property type="entry name" value="PRP8_domainIV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043173">
        <property type="entry name" value="Prp8_domainIV_fingers"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043172">
        <property type="entry name" value="Prp8_domainIV_palm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019581">
        <property type="entry name" value="Prp8_U5-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042516">
        <property type="entry name" value="Prp8_U5-snRNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019580">
        <property type="entry name" value="Prp8_U6-snRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019582">
        <property type="entry name" value="RRM_spliceosomal_PrP8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR PRP8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11140:SF0">
        <property type="entry name" value="PRE-MRNA-PROCESSING-SPLICING FACTOR 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08082">
        <property type="entry name" value="PRO8NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08083">
        <property type="entry name" value="PROCN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08084">
        <property type="entry name" value="PROCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12134">
        <property type="entry name" value="PRP8_domainIV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10598">
        <property type="entry name" value="RRM_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10597">
        <property type="entry name" value="U5_2-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10596">
        <property type="entry name" value="U6-snRNA_bdg"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="PRO8NT" evidence="7">
        <location>
            <begin position="46"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="PROCN" evidence="8">
        <location>
            <begin position="386"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="domain" description="RNA recognition motif spliceosomal PrP8" evidence="12">
        <location>
            <begin position="976"/>
            <end position="1066"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-processing-splicing factor 8 U5-snRNA-binding" evidence="11">
        <location>
            <begin position="1242"/>
            <end position="1379"/>
        </location>
    </feature>
    <feature type="domain" description="Pre-mRNA-processing-splicing factor 8 U6-snRNA-binding" evidence="10">
        <location>
            <begin position="1449"/>
            <end position="1606"/>
        </location>
    </feature>
    <feature type="domain" description="PRP8" evidence="13">
        <location>
            <begin position="1770"/>
            <end position="1999"/>
        </location>
    </feature>
    <feature type="domain" description="PROCT" evidence="9">
        <location>
            <begin position="2249"/>
            <end position="2362"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF10596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF10598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF12134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK89040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2379" mass="279299" checksum="F7E34085B1982FD4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUJ7</accession>
    <name>Q5CUJ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TBC1 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626817.1">
        <property type="nucleotide sequence ID" value="XM_626817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUJ7"/>
    <dbReference type="FunCoup" id="Q5CUJ7">
        <property type="interactions" value="403"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUJ7"/>
    <dbReference type="GeneID" id="3373905"/>
    <dbReference type="KEGG" id="cpv:cgd3_2560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2560"/>
    <dbReference type="InParanoid" id="Q5CUJ7"/>
    <dbReference type="OMA" id="SCYNIFN"/>
    <dbReference type="OrthoDB" id="26371at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957:SF26">
        <property type="entry name" value="LD44506P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="43"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="369" mass="43610" checksum="7E286B9883ACE91A" modified="2005-04-12" version="1">MSLDVLINSTEPTKEGRFLSVLEQECIDIKLLQDLLWSGVPRGSPPELRRDAWQIMLGYLPPRKDRKNSYKLKKINEYRLLLKEHIEHDNYSEQEKKILRQIRVDLPRTSIEYESLKNRIILDLMERVLFLWAIRNPASGYVQGINDLLPPFLVVFLLPFSPEGDIELLDINKISSERMFEIEVEIYWCLTRMLDTLQENYVTEQPGIHKLIVHLQDIIKRTNKPLFQHLKEQGVDFLQFSFRWMNCLLTREFPTKCVVRLWDTYIAENTLNKTNKPLRSSSITSLDQIPTGNNVISHFNAFHVYVCAAFLLHWEKKLRNMEFSEIMLFLQNSPTKNWTERDIDSLLAQAFVLQSLFHFSPRHLIDYSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUQ6</accession>
    <name>Q5CUQ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">DNA-directed RNA polymerase 2 subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd3_1870</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626758.1">
        <property type="nucleotide sequence ID" value="XM_626758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUQ6"/>
    <dbReference type="FunCoup" id="Q5CUQ6">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUQ6"/>
    <dbReference type="GeneID" id="3374152"/>
    <dbReference type="KEGG" id="cpv:cgd3_1870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1870"/>
    <dbReference type="InParanoid" id="Q5CUQ6"/>
    <dbReference type="OMA" id="DTSMVLF"/>
    <dbReference type="OrthoDB" id="282270at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001193">
        <property type="term" value="P:maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10508">
        <property type="entry name" value="Zn-ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019761">
        <property type="entry name" value="DNA-dir_RNA_pol-M_15_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001529">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034012">
        <property type="entry name" value="Zn_ribbon_RPB9_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02150">
        <property type="entry name" value="Zn_ribbon_RPB9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00661">
        <property type="entry name" value="RPOL9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01030">
        <property type="entry name" value="RNA_POL_M_15KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="10">
        <location>
            <begin position="78"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="167" mass="19593" checksum="1AD2307CADF529F6" modified="2005-04-12" version="1">MERDIRFCPECNNILCPKENIERRKLLYACRNCEYFSYADPTNAEENVVNCITYQYEGKEDILVARGLHQDPTLGRTLEWNCRGCGHNVAVFFQLPERVCSEAMTLVFVCVSCGEWVKEGKETDDEMDYSEDHTNIFNRPYFNIDNISFEPKKEETEENNYQQIKEG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUS2</accession>
    <name>Q5CUS2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1700</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89124.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626742.1">
        <property type="nucleotide sequence ID" value="XM_626742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUS2"/>
    <dbReference type="GeneID" id="3374014"/>
    <dbReference type="KEGG" id="cpv:cgd3_1700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1700"/>
    <dbReference type="InParanoid" id="Q5CUS2"/>
    <dbReference type="OrthoDB" id="341866at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254253" evidence="2">
        <location>
            <begin position="23"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="194"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="652"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="662"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="681"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89124.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="702" mass="79916" checksum="61896F9B74B8B616" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUW9</accession>
    <name>Q5CUW9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89162.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626695.1">
        <property type="nucleotide sequence ID" value="XM_626695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUW9"/>
    <dbReference type="GeneID" id="3374166"/>
    <dbReference type="KEGG" id="cpv:cgd3_1170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1170"/>
    <dbReference type="InParanoid" id="Q5CUW9"/>
    <dbReference type="OrthoDB" id="10372825at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254427" description="Secreted protein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="300"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89162.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="300" mass="34353" checksum="C5B436D61E4D5DE7" modified="2005-04-12" version="1">MLFKCLLCIVFFSQISNIKHCAPAPDIVRKSHKKHGVEFNAEISLLQTGARSLSYGFKRQASGGIPPDPYENLVELYEAEYNPTATVGLLQKYNNVFLRTLSKRTLENTQDFLVRALRSDITDCIILEEKLDVKLSVYLVEPEKFHEEIQILLTNYKAMIESKVESIAKYSKILTRVMSSLLSRMIKEYRTTSYSLFKLNNDNIQAIQRGLSFYQGLVSYLTDMGRMLSCNHNYMKETALCAFITTSIADYSSRYSSLIETLPGTKEYQMFEDIDHEEDIKEKKIGKSVGKKGKHGTKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUY9</accession>
    <name>Q5CUY9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Hypothetical conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CND2 H2 (condensin-2 subunit 2) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89176.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626675.1">
        <property type="nucleotide sequence ID" value="XM_626675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUY9"/>
    <dbReference type="STRING" id="353152.Q5CUY9"/>
    <dbReference type="GeneID" id="3374180"/>
    <dbReference type="KEGG" id="cpv:cgd3_950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_950"/>
    <dbReference type="InParanoid" id="Q5CUY9"/>
    <dbReference type="OMA" id="FDPPEHK"/>
    <dbReference type="OrthoDB" id="10038475at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051306">
        <property type="term" value="P:mitotic sister chromatid separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031737">
        <property type="entry name" value="CNDH2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009378">
        <property type="entry name" value="H2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031739">
        <property type="entry name" value="Ncaph2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14324">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14324:SF3">
        <property type="entry name" value="CONDENSIN-2 COMPLEX SUBUNIT H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16858">
        <property type="entry name" value="CNDH2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06278">
        <property type="entry name" value="CNDH2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensin II complex subunit H2 N-terminal" evidence="5">
        <location>
            <begin position="12"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Condensin-2 complex subunit H2 C-terminal" evidence="6">
        <location>
            <begin position="542"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="301"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="674"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="301"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="697"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF06278"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89176.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="706" mass="81380" checksum="5211EC3A6260F95E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV05</accession>
    <name>Q5CV05_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HMG-like nuclear protein, Nhp2p, pelota RNA binding domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_760</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626659.1">
        <property type="nucleotide sequence ID" value="XM_626659.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV05"/>
    <dbReference type="STRING" id="353152.Q5CV05"/>
    <dbReference type="GeneID" id="3373811"/>
    <dbReference type="KEGG" id="cpv:cgd3_760"/>
    <dbReference type="InParanoid" id="Q5CV05"/>
    <dbReference type="OMA" id="EDNYEAR"/>
    <dbReference type="OrthoDB" id="5364946at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="3">
        <location>
            <begin position="62"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="172" mass="19602" checksum="2CB9ED56223BEBC9" modified="2005-04-12" version="1" fragment="single">KVEEMKEDTTELSHVEDEIEMEGEEAITNKSAIADPIFGGKLLERCLKLVKKVQEYEKEERKEKGSKKVRYIRRGVHEVTKSIRKGQTGLVLIACDIHPVDIIAHIPILCEEKNIYYGYLGSKKTLGTICKSKRPASVLMISFNSESSVQDKPFYSIYSKVISNIKKVHPYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV06</accession>
    <name>Q5CV06_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626658.1">
        <property type="nucleotide sequence ID" value="XM_626658.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV06"/>
    <dbReference type="GeneID" id="3374135"/>
    <dbReference type="KEGG" id="cpv:cgd3_750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_750"/>
    <dbReference type="InParanoid" id="Q5CV06"/>
    <dbReference type="OrthoDB" id="343271at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="131"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="194" mass="21745" checksum="A3D33A865AC345FD" modified="2005-04-12" version="1">MNKRKERSEGVEVSCHEQLMGGNFDIYGFGDKRRNLNEYYNGRQVLGFIGDICEKENSVLAPTASLGTGNEITEAGVGSENVLGTRTVSGTEVEGRRLQDLESAEEQQSYGQLVKKYESLQNSHTTLQKVVKSLLDKLSQLNELCSQKDRELSEYKVQLKKLVDANETLNMYIQSSHSSIMSNSMINKFGSDIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV45</accession>
    <name>Q5CV45_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89227.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626619.1">
        <property type="nucleotide sequence ID" value="XM_626619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV45"/>
    <dbReference type="GeneID" id="3374001"/>
    <dbReference type="KEGG" id="cpv:cgd3_340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_340"/>
    <dbReference type="InParanoid" id="Q5CV45"/>
    <dbReference type="OMA" id="NICTLYK"/>
    <dbReference type="OrthoDB" id="342394at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="132"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89227.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="374" mass="42436" checksum="23E0933E7513B43F" modified="2005-04-12" version="1">MFKSIKKKRDEFLFKWNRRRYSYRMGWYYSMLSIVSGIIILVSFILFFLLKMNSCTGRRCGIFRTFSCSPTSVSLLSSAFISLGSIYSIKSAFSYMLSRLLYSFANYRTTDFMALGKFASILGALVKHIPFLIALCTICNGIICITGVIYILIGLCSHSYSSATQIIVDNCRLYFSNCENPTVNSIFDCNDPSQLISSPFLQLRCLPGSSEICRYSQELKSGSNPCTKDMLKSYLISTGDSEIIEELEKLTGRTLSISMPNQVDKENSRKIIERKLGSTYISTLQGVSNRELLDLYLLPSSPSDQSELISSYGFSDLYAAARVWIAAACYTYVSTTILFFFVKYFSPQDSCFSFVRSPNEFFLLKILNIFTPWQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV65</accession>
    <name>Q5CV65_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Srp101p GTpase, signal recognition particle receptor alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd8_5260</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GTP-binding SRP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627404.1">
        <property type="nucleotide sequence ID" value="XM_627404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV65"/>
    <dbReference type="FunCoup" id="Q5CV65">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV65"/>
    <dbReference type="GeneID" id="3374225"/>
    <dbReference type="KEGG" id="cpv:cgd8_5260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5260"/>
    <dbReference type="InParanoid" id="Q5CV65"/>
    <dbReference type="OMA" id="NCEESKG"/>
    <dbReference type="OrthoDB" id="1727884at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14826">
        <property type="entry name" value="SR_alpha_SRX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17876">
        <property type="entry name" value="SRalpha_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000188">
        <property type="entry name" value="signal recognition particle receptor subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43134:SF1">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE RECEPTOR SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 10" id="KW-0675">Receptor</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="9">
        <location>
            <begin position="521"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="139"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="149"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="193"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="548" mass="61100" checksum="6E35DB97D3F0AE18" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV77</accession>
    <name>Q5CV77_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RRM domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_5130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627392.1">
        <property type="nucleotide sequence ID" value="XM_627392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV77"/>
    <dbReference type="FunCoup" id="Q5CV77">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV77"/>
    <dbReference type="GeneID" id="3374663"/>
    <dbReference type="KEGG" id="cpv:cgd8_5130"/>
    <dbReference type="InParanoid" id="Q5CV77"/>
    <dbReference type="OMA" id="IVISKPM"/>
    <dbReference type="OrthoDB" id="10258585at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005684">
        <property type="term" value="C:U2-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034393">
        <property type="entry name" value="TatSF1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608:SF0">
        <property type="entry name" value="HIV TAT-SPECIFIC FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15608">
        <property type="entry name" value="SPLICING FACTOR U2AF-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="40"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="274" mass="31711" checksum="B1E814B49FDC94C8" modified="2005-04-12" version="1" fragment="single">KKAIVSFYLIRLYIEFINAMDSKKIKKLNKKKAKGTLVNTSIYVQGLPKDITFEEMKYFFGRGGIIKIDPTTLSPKIKLYNDELTKEFSGNALVVYKYEQSIELALKYLNETEIRPGFKVKIEKAIFNKSSKSNIAPLSETEINKKRKQLKAAEMEEERLLSWSNEQHSLNSNIASRIVVLRPMYSRKEAEMYPEGDDFYSELEIEVQEEVTKYCEVVSVTCIPRHPQGIVCVKLKSQHDAEIVIDIFNQRYFDGRQIEVHMYDGSTDFKASCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVA2</accession>
    <name>Q5CVA2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular protein with a signal peptide, kazal domain and mucin like low complexity repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_4830</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627367.1">
        <property type="nucleotide sequence ID" value="XM_627367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVA2"/>
    <dbReference type="STRING" id="353152.Q5CVA2"/>
    <dbReference type="GeneID" id="3374372"/>
    <dbReference type="KEGG" id="cpv:cgd8_4830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4830"/>
    <dbReference type="InParanoid" id="Q5CVA2"/>
    <dbReference type="OMA" id="NCISITF"/>
    <dbReference type="OrthoDB" id="343609at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00050">
        <property type="entry name" value="Kazal_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00280">
        <property type="entry name" value="KAZAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005697453" evidence="2">
        <location>
            <begin position="20"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="3">
        <location>
            <begin position="31"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="152"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="475" mass="50081" checksum="C8CDBB2181441505" modified="2005-04-12" version="1">MFIKRNILSLATLLVGASASGIFRQFGDKITQQANPCHITCPREYAPVCATDAETYENLCLFGVAKCMNRDLQLVANVTCPDLLIHLTHLAQKGMVESMNAIDSTYQTFGNITKGTAEMISSTLDSVPLIKLPNFNLPIFGIPPIPPQVLKTTSTSTSTSTTTTTTTSTSTSTTENTSTNFESDSSSESTSEYTSTSTSTSSTITSDIEPTSTSTSTSASTSTSTSTSASTSALPTSTTTIATSTKSSRKLIEIPSLEQGASGVIAQVTKTIQSALSGSGVSGSSPTTSSSAALGLNNLDDARTTIEGMVKTIPYTPGKNSSNILLVDGVSQIVKLPNGKESKNLLSNITSTESFNLPNITNLTNGSLSNITEKITSRNITLNGENLISNPNFQSLRNLTSSTLDNNNISNTTAINGTNSGLNINGTSLLTDSKFNKLVNGRFNTTDIFKGIGNTINNITKNIKEQVENEIENIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVA8</accession>
    <name>Q5CVA8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RSE1/DDB1/CPSF1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89609.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627361.1">
        <property type="nucleotide sequence ID" value="XM_627361.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVA8"/>
    <dbReference type="GeneID" id="3374349"/>
    <dbReference type="KEGG" id="cpv:cgd8_4770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4770"/>
    <dbReference type="InParanoid" id="Q5CVA8"/>
    <dbReference type="OMA" id="WSINDIN"/>
    <dbReference type="OrthoDB" id="339551at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="1">
        <location>
            <begin position="1713"/>
            <end position="1906"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89609.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1965" mass="222838" checksum="31DDC0BE334FE57C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVP3</accession>
    <name>Q5CVP3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ylr022cp-like protein that has a C2H2 zinc finger and is a component of the exosome</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd8_3310</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">Associates with the 60S ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SDO1/SBDS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627226.1">
        <property type="nucleotide sequence ID" value="XM_627226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVP3"/>
    <dbReference type="FunCoup" id="Q5CVP3">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVP3"/>
    <dbReference type="GeneID" id="3374615"/>
    <dbReference type="KEGG" id="cpv:cgd8_3310"/>
    <dbReference type="InParanoid" id="Q5CVP3"/>
    <dbReference type="OMA" id="CYKNKVF"/>
    <dbReference type="OrthoDB" id="10253092at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1250.10:FF:000001">
        <property type="entry name" value="SBDS, ribosome maturation factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1250.10">
        <property type="entry name" value="Ribosome maturation protein SBDS, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.900">
        <property type="entry name" value="SBDS protein C-terminal domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018023">
        <property type="entry name" value="Ribosome_mat_SBDS_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036786">
        <property type="entry name" value="Ribosome_mat_SBDS_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002140">
        <property type="entry name" value="Sdo1/SBDS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039100">
        <property type="entry name" value="Sdo1/SBDS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018978">
        <property type="entry name" value="SDO1/SBDS_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037188">
        <property type="entry name" value="Sdo1/SBDS_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019783">
        <property type="entry name" value="SDO1/SBDS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00291">
        <property type="entry name" value="RNA_SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10927:SF1">
        <property type="entry name" value="RIBOSOME MATURATION PROTEIN SBDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09377">
        <property type="entry name" value="SBDS_domain_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01172">
        <property type="entry name" value="SBDS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89895">
        <property type="entry name" value="FYSH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109728">
        <property type="entry name" value="Hypothetical protein AF0491, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01267">
        <property type="entry name" value="UPF0023"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS N-terminal" evidence="8">
        <location>
            <begin position="20"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosome maturation protein SDO1/SBDS central" evidence="9">
        <location>
            <begin position="116"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00049708"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF09377"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="379" mass="44015" checksum="9883976BA15764E1" modified="2005-04-12" version="1" fragment="single">FTIFLKMSLFQPSNQIKLTNVAVVRYKSHGKRFEVACYKNKILNWRSGVEWDLDEVLQIRTIFANVSKGQLANSDDLNTVFGTNSIDNICKTILSKGEIQISETERSYMLDKQFTDICHMLNRMTVNPKNNLPLSVKIIESELKDSGFSVSLNKTTKEQALKAFDILKKRIPDQIERAKMMLKLSVDIVNKQNITKKLNEFNVFPISSEEKHNTYTITFLCEPRYYREIDQLDCKLLLLDSNVKTLDKNSNFDNAEAIQLELSNKSDILFNSITSDPRHIIDKKLEKTEVSIKENANAFVKPIVSSLNIEESKREIKSNMLLCRKCNIQLMDHNAFKQHYRSEWHIFNTKRNARKMEPISEEEFLELQQDIKLGFLAVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVS7</accession>
    <name>Q5CVS7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Vps60p /Vps20p like protein involved in vacuolar protein sorting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_2920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627192.1">
        <property type="nucleotide sequence ID" value="XM_627192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVS7"/>
    <dbReference type="GeneID" id="3374326"/>
    <dbReference type="KEGG" id="cpv:cgd8_2920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2920"/>
    <dbReference type="InParanoid" id="Q5CVS7"/>
    <dbReference type="OMA" id="WICANNN"/>
    <dbReference type="OrthoDB" id="337946at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007034">
        <property type="term" value="P:vacuolar transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="453" mass="52372" checksum="0334EA8B4BFD6BEE" modified="2005-04-12" version="1">MRMGTNSIFPKVKDIGEWQKLCSYNFHDQEEYKLEWWLGIIEKFCDKNKSLLIEINSLKAIAQEEFKFWPIEVLSLPNIFKGLIKRKKLVNLDFINKYMVKIWENAVEVEKSQSRSKVSRIGFAWVRSIIGTFFNDTFILETDESTAELDTFVCIPLLDKLSNKLVNDINRGSLGSISKSTGIDELLILSTKFNDYLVQNYELCETAKNVLNDMMIWYFITYSPGEWSLKPFVVHKGNNNHVNAIKFSRSYSSVAKKEIEINDTDIADIILKITEEDLQKSLTNLEKKFLFHDSKCKEYALCDQKQLAINHLKQRHQIEKALNDVNEQLLLLSQSRVTLDTSNARISLVNALETSTSITKDIFNESEILKKLENINIMREEVEVTQESINSMIKSCVKDASKNMEATSYDLERELEEILHKADISIPAIEQNCQFQESPSEFEAEKHQVTNTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVU4</accession>
    <name>Q5CVU4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89460.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627175.1">
        <property type="nucleotide sequence ID" value="XM_627175.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVU4"/>
    <dbReference type="GeneID" id="3374338"/>
    <dbReference type="KEGG" id="cpv:cgd8_2750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2750"/>
    <dbReference type="InParanoid" id="Q5CVU4"/>
    <dbReference type="OrthoDB" id="341366at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="283"/>
            <end position="310"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89460.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="315" mass="36627" checksum="43C922AEF617AE25" modified="2005-04-12" version="1">MNVIFELIRNGIRLVRLKVGSFSRDNFEEFTRVVYDEYSGFHIVEEFDIAESESFLIVSKECLIQNCEFKCCSSNSSEYVREIKSGANQINLDPNCKSLSRQQQFLDFESTKINAHESGSALACITPTKTSSMDISRNRRDDFLINSIFEDTNEPYFLKGLINSEKEKFELTNFVDTPILFREDCVTPKLPDSKYRQNLKNDKICFTPDGFDCHFDDNTKLNDDFKKSDILLLLRLKRKKLAMLESQLKRDVKLLNINGSSENESKPDNLSSIEKMVRCPAQLYFIKRRIENIKENIENTERDIAILEEKTSETY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW41</accession>
    <name>Q5CW41_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Alcohol dehydrogenase 4</fullName>
            <ecNumber evidence="2">1.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Alcohol dehydrogenase IV</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd8_1720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">In the N-terminal section; belongs to the aldehyde dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627078.1">
        <property type="nucleotide sequence ID" value="XM_627078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW41"/>
    <dbReference type="STRING" id="353152.Q5CW41"/>
    <dbReference type="GeneID" id="3374407"/>
    <dbReference type="KEGG" id="cpv:cgd8_1720"/>
    <dbReference type="InParanoid" id="Q5CW41"/>
    <dbReference type="OMA" id="KIMWVLY"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008774">
        <property type="term" value="F:acetaldehyde dehydrogenase (acetylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015976">
        <property type="term" value="P:carbon utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006113">
        <property type="term" value="P:fermentation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd08178">
        <property type="entry name" value="AAD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07122">
        <property type="entry name" value="ALDH_F20_ACDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1970:FF:000003">
        <property type="entry name" value="Alcohol dehydrogenase, iron-containing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1090.10:FF:000001">
        <property type="entry name" value="Aldehyde-alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.605.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.309.10">
        <property type="entry name" value="Aldehyde Dehydrogenase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034789">
        <property type="entry name" value="AAD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018211">
        <property type="entry name" value="ADH_Fe_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016161">
        <property type="entry name" value="Ald_DH/histidinol_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016163">
        <property type="entry name" value="Ald_DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016162">
        <property type="entry name" value="Ald_DH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015590">
        <property type="entry name" value="Aldehyde_DH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012079">
        <property type="entry name" value="Bifunc_Ald-ADH"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010378">
        <property type="entry name" value="PRK13805.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00171">
        <property type="entry name" value="Aldedh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000111">
        <property type="entry name" value="ALDH_ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53720">
        <property type="entry name" value="ALDH-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00913">
        <property type="entry name" value="ADH_IRON_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00060">
        <property type="entry name" value="ADH_IRON_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aldehyde dehydrogenase" evidence="11">
        <location>
            <begin position="12"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="12">
        <location>
            <begin position="448"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="13">
        <location>
            <begin position="640"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00035645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00074847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00076695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK89685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="867" mass="94735" checksum="FDCD5147CF550538" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW69</accession>
    <name>Q5CW69_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_1430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627050.1">
        <property type="nucleotide sequence ID" value="XM_627050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW69"/>
    <dbReference type="STRING" id="353152.Q5CW69"/>
    <dbReference type="GeneID" id="3374581"/>
    <dbReference type="KEGG" id="cpv:cgd8_1430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1430"/>
    <dbReference type="InParanoid" id="Q5CW69"/>
    <dbReference type="OMA" id="NNCINAM"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="2">
        <location>
            <begin position="412"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="752" mass="86965" checksum="8EC67E8CDD22C766" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW84</accession>
    <name>Q5CW84_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Centrin, caltractin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_1280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the centrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89676.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627035.1">
        <property type="nucleotide sequence ID" value="XM_627035.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW84"/>
    <dbReference type="STRING" id="353152.Q5CW84"/>
    <dbReference type="GeneID" id="3374398"/>
    <dbReference type="KEGG" id="cpv:cgd8_1280"/>
    <dbReference type="InParanoid" id="Q5CW84"/>
    <dbReference type="OMA" id="YMDVDEL"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000232">
        <property type="entry name" value="Centrin-2, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF59">
        <property type="entry name" value="EF-HAND SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="22"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="58"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="95"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="131"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89676.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="166" mass="18856" checksum="881B6D45407AA470" modified="2005-04-12" version="1" fragment="single">TMKRRTSPTRKRGNEWPGLTDDEIEEIRKTFNLFDTDGSGTIDPKEMKAAMQSLGFESQNPTMYQLIADLDREGSSAIDFEEFLDAIASKLGDKDSREGIQKIFAMFDDDKTGSITLKNLKRVAHELGETMTDDELREMIERADSNGDGEISFEDFYSIMTKKTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWB1</accession>
    <name>Q5CWB1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_1000</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627008.1">
        <property type="nucleotide sequence ID" value="XM_627008.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWB1"/>
    <dbReference type="GeneID" id="3374433"/>
    <dbReference type="KEGG" id="cpv:cgd8_1000"/>
    <dbReference type="InParanoid" id="Q5CWB1"/>
    <dbReference type="OMA" id="HTIVNIP"/>
    <dbReference type="OrthoDB" id="10333356at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="389" mass="44014" checksum="19A1C7BC2CF8399E" modified="2005-04-12" version="1">MNEIFNMNNFDKFYVSAYLETFSSLVLELGIRDNILSQSMDIGSGGEKGEIFKLKIRQSLINLVQSDSTVSLIEKILNYIIICRRKGNNLDADKSSCLMGISILLLSMLSSKIKIFRTNGRLESLIDSILAHPTLLFHAEKSSKCGLNSRFSSDEYDNSLIDNNTTSFNLCNYCLNFGFNHNIEDIKLITNVSIIVALLRLNHVNSRAISKSNLIKDIFLQSISGILNTNNKASSVSHGYMGIILSSIYLSYDQIQSLSLVHNLYIQKFLVKEFVCDVLNFDKNPVENLNLSPCMIFHYSVLFSYLVFILKTTPWWLNISDLINLTFINKLGKIYKSLQTSAIIYNDENDNIGEYLISLTEILLKIVQETIMARSNSSSSYIQGKLISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWV4</accession>
    <name>Q5CWV4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_3580</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627700.1">
        <property type="nucleotide sequence ID" value="XM_627700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWV4"/>
    <dbReference type="FunCoup" id="Q5CWV4">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWV4"/>
    <dbReference type="GeneID" id="3375719"/>
    <dbReference type="KEGG" id="cpv:cgd6_3580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3580"/>
    <dbReference type="InParanoid" id="Q5CWV4"/>
    <dbReference type="OMA" id="LWRCVTS"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="99"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="275" mass="31415" checksum="D99C9A9D89B4C505" modified="2007-04-03" version="1">MFNDSSPQGWYKNLPPITRSILTITFFSTLLITFGMLNPWYILFDWEYIFRKAQIWRFLTSFFFVGPFSIGWIMSQWMFTSFSSKLERSGSVGSSSGSYLYFILILMTGINIIGTAFDYPTGRKIGGSSLIFGIIYYWSKKFPTSLVSIWGFTLQAYQLPYALLFLDVLTGNSLIDDLIGLLAGHSYYYIRDIIYENNANNFLARTPKHFDKFVDYSSLLIKNYVYDFSSLNGHPNVINYPNSNVNRAGSSYNPFSGNSAQPRAFSGRGFRLGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWV6</accession>
    <name>Q5CWV6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA pseudouridine(55) synthase</fullName>
            <ecNumber evidence="2">5.4.99.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_3560</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase Pus10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.4.99.25" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627698.1">
        <property type="nucleotide sequence ID" value="XM_627698.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWV6"/>
    <dbReference type="STRING" id="353152.Q5CWV6"/>
    <dbReference type="GeneID" id="3375721"/>
    <dbReference type="KEGG" id="cpv:cgd6_3560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3560"/>
    <dbReference type="InParanoid" id="Q5CWV6"/>
    <dbReference type="OMA" id="WHYNSSS"/>
    <dbReference type="OrthoDB" id="271937at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160148">
        <property type="term" value="F:tRNA pseudouridine(55) synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.3190:FF:000001">
        <property type="entry name" value="tRNA pseudouridine synthase Pus10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2510">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.3190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039894">
        <property type="entry name" value="Pus10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048741">
        <property type="entry name" value="Pus10-like_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21568:SF0">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE PUS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21238">
        <property type="entry name" value="Pus10_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pus10-like C-terminal" evidence="5">
        <location>
            <begin position="230"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="domain" description="Pus10-like C-terminal" evidence="5">
        <location>
            <begin position="362"/>
            <end position="515"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012787"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF21238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="539" mass="62425" checksum="DC1A727F18BB1725" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWV8</accession>
    <name>Q5CWV8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_3530</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627696.1">
        <property type="nucleotide sequence ID" value="XM_627696.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWV8"/>
    <dbReference type="GeneID" id="3375718"/>
    <dbReference type="KEGG" id="cpv:cgd6_3530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3530"/>
    <dbReference type="InParanoid" id="Q5CWV8"/>
    <dbReference type="OMA" id="WISHDYS"/>
    <dbReference type="OrthoDB" id="337348at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="629" mass="71950" checksum="A852C36E5CCD245A" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWW7</accession>
    <name>Q5CWW7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM (2xRRMs) domaincontaining protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_3430</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89965.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627687.1">
        <property type="nucleotide sequence ID" value="XM_627687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWW7"/>
    <dbReference type="STRING" id="353152.Q5CWW7"/>
    <dbReference type="GeneID" id="3375710"/>
    <dbReference type="KEGG" id="cpv:cgd6_3430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3430"/>
    <dbReference type="InParanoid" id="Q5CWW7"/>
    <dbReference type="OMA" id="CTIEFEN"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="95"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="242"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="278"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89965.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="293" mass="33174" checksum="4DAB23A35CCBCD3A" modified="2007-04-03" version="1">MTENCVFIRNLSPLANKKSVLNIFNELEDEIIDIEFHNYPESDQRFCQISFKSSNGVTKSIGFNGSTLLGVPMSITVLPPIQIQKSEQKRIVSNREISVKNLPSSLSDLRITSIFQKYGQIVSIKRQDPNINSNSIIIEFQNESSAADLIEKRYLTLESGEKIEISSDFEIQKYIPSNLETNSNLHDINDTLLNLESIPVPLAYQQIKKLEWDSKLSKIYSIKKKIEERLLNTLNNDLKLQSGFNQDSYQPRSPTPSPSPPLSDTKVPLDKKVITGGRTRSLSRSVSPFHSNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWX3</accession>
    <name>Q5CWX3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative zinc finger and putative FYVE domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_3360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627681.1">
        <property type="nucleotide sequence ID" value="XM_627681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWX3"/>
    <dbReference type="STRING" id="353152.Q5CWX3"/>
    <dbReference type="GeneID" id="3375705"/>
    <dbReference type="KEGG" id="cpv:cgd6_3360"/>
    <dbReference type="InParanoid" id="Q5CWX3"/>
    <dbReference type="OrthoDB" id="79871at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="135" mass="15769" checksum="45A16DC1C0092275" modified="2005-04-12" version="1">MKDTEICEECMNLDEFHKICCTLCGRVKCSNCNISNTVEYKIYDKLICEECISKLYLETNNILQEELDVKDQINLNLKKGLEEQFQIISKCKQFIIALEEIISFQGLWKSICEIEGTENIQNLLFESQGKFSFMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWY6</accession>
    <name>Q5CWY6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Nop2p family of SUN/fmu RNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_3230</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89949.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627668.1">
        <property type="nucleotide sequence ID" value="XM_627668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWY6"/>
    <dbReference type="FunCoup" id="Q5CWY6">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWY6"/>
    <dbReference type="GeneID" id="3375694"/>
    <dbReference type="KEGG" id="cpv:cgd6_3230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3230"/>
    <dbReference type="InParanoid" id="Q5CWY6"/>
    <dbReference type="OMA" id="ITACEKP"/>
    <dbReference type="OrthoDB" id="427002at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009383">
        <property type="term" value="F:rRNA (cytosine-C5-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1170:FF:000001">
        <property type="entry name" value="Ribosomal RNA methyltransferase Nop2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1170">
        <property type="entry name" value="Sun protein, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011023">
        <property type="entry name" value="Nop2p"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023273">
        <property type="entry name" value="RCMT_NOP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00446">
        <property type="entry name" value="nop2p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF30">
        <property type="entry name" value="28S RRNA (CYTOSINE(4447)-C(5))-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02012">
        <property type="entry name" value="RCMTNOP2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9 12" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="7 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="11">
        <location>
            <begin position="150"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="486"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="487"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="520"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="533"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="242"/>
            <end position="248"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="266"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="310"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89949.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="542" mass="60546" checksum="053E028E978A12EF" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX04</accession>
    <name>Q5CX04_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-polymerase II-associated protein 3-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_3040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89934.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627650.1">
        <property type="nucleotide sequence ID" value="XM_627650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX04"/>
    <dbReference type="GeneID" id="3375679"/>
    <dbReference type="KEGG" id="cpv:cgd6_3040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3040"/>
    <dbReference type="InParanoid" id="Q5CX04"/>
    <dbReference type="OMA" id="NDIRNSH"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025986">
        <property type="entry name" value="RPAP3-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13877">
        <property type="entry name" value="RPAP3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA-polymerase II-associated protein 3-like C-terminal" evidence="2">
        <location>
            <begin position="297"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF13877"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89934.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="434" mass="51461" checksum="8D3425D30EAA0A94" modified="2007-04-03" version="1">MEEFHRIPIVIVEDEDELERIVNEGKNKLEVQDEDEDKKSRIDPKDLANRMKEKGGQCYKEKKFDEALGFYLKALGILELEQSLKENGEDFELLMGEIVLRSNCIACYVEKKDFERAVSESRKLLKYINEEGDFYLKKNGELPTLWVNIENKTRYRLSVSLYNLFGCGDVFSDEISKSSINESFEMIQTVLDYYQHWLKVSPPHEITVLYSKVKRAIESQNYETKKVNSSLENLDFREKEVQSQTEKQDEEEISTKQNESHYLTSYITCFLEEYFEESGSCPKSIKSPIQIVDKMNCNNSIEFLRIWQNIYQNNQFIDYYLFFSHIFTNLDKIYNKTEIEVNILEKILERISVVLDELLKNSFQSKPKEKLISHIFKIIQNLEKTKRFDFVVLMLNENFQILNKMVQFEKYLSNNLLQEIKHFQENQTSKGIQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX15</accession>
    <name>Q5CX15_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627639.1">
        <property type="nucleotide sequence ID" value="XM_627639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX15"/>
    <dbReference type="GeneID" id="3376162"/>
    <dbReference type="KEGG" id="cpv:cgd6_2910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2910"/>
    <dbReference type="InParanoid" id="Q5CX15"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="202" mass="23808" checksum="C0A6EF5986527881" modified="2005-04-12" version="1">MKLSCNFLILLEFACMLIITGGIIIYLYIQEFPSNNNPRSFFLENYPQFDYLDCNLNFDGNLDQINLQNITKQNRDNTTEICLSDEQIRIFNLTKNLRPRLNTNYSGYMGPWIEDGVFCNWITQYSTKQIKVCNESEPIPPVYIPIFWTSIHRNKVELDLKKEWKKEAQDVLNSLKNETMYFTVLQVSFKIFGIIPNIQSFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX35</accession>
    <name>Q5CX35_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_2670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627619.1">
        <property type="nucleotide sequence ID" value="XM_627619.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX35"/>
    <dbReference type="GeneID" id="3376144"/>
    <dbReference type="KEGG" id="cpv:cgd6_2670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2670"/>
    <dbReference type="InParanoid" id="Q5CX35"/>
    <dbReference type="OrthoDB" id="340081at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="490" mass="56329" checksum="B07C25E4A8C912FF" modified="2007-04-03" version="1">MLLASENSFLEKYNNCPDLQLEFNGGKDLVIEEKTGKETEIIIPNNKEFEESTNTVINQAECEIPNCKGENIVNCHHSFGDGIDKSGLKELNPYYVLQGDSFSSSKICNIGEIIGSESLSGVVSDSNIHEELFSIGCQESDDCRELKVFTNEIGGLKSDHSQHKALSNFHFHHNFSMFGEVIQDNGQRIVHSQCYQHQIRSSGLDKFTAVDRNGKRSILNEVETQAQLMPSIPGVYFDRRQIGYRVRYHNSYVGWVALSRHSSIKDAYEYAKQLWLKARNKSKLNKCQTDQIEAGNRGMGARKRARFTVYDDNQELNQTILCKSGPSSEDNIYFDSSHIENNQIFQTKCYNSDYSSGNDGYGVHSIIENGYTFSENAMEKQVLEKESSNELSKMSQYSALETMRKLYYATQEYMEKWPSEDGHYTIHWSNTSDLSSYLYGEENEQNHKKDLNNKKSKNQRKIYINSEKQNINFDNLNLNKKQLESFNYIW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX39</accession>
    <name>Q5CX39_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Vesicle-associated membrane protein,MSP (Major sperm protein) domain, transmembrane domain or GPI at C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_2620</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VAMP-associated protein (VAP) (TC 9.B.17) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627615.1">
        <property type="nucleotide sequence ID" value="XM_627615.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX39"/>
    <dbReference type="FunCoup" id="Q5CX39">
        <property type="interactions" value="82"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX39"/>
    <dbReference type="GeneID" id="3375887"/>
    <dbReference type="KEGG" id="cpv:cgd6_2620"/>
    <dbReference type="InParanoid" id="Q5CX39"/>
    <dbReference type="OMA" id="VTKYMGY"/>
    <dbReference type="OrthoDB" id="264603at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090158">
        <property type="term" value="P:endoplasmic reticulum membrane organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061817">
        <property type="term" value="P:endoplasmic reticulum-plasma membrane tethering"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000535">
        <property type="entry name" value="MSP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008962">
        <property type="entry name" value="PapD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016763">
        <property type="entry name" value="VAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809:SF6">
        <property type="entry name" value="AT11025P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10809">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00635">
        <property type="entry name" value="Motile_Sperm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF019693">
        <property type="entry name" value="VAMP-associated"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49354">
        <property type="entry name" value="PapD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50202">
        <property type="entry name" value="MSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="243"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="domain" description="MSP" evidence="8">
        <location>
            <begin position="21"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="194"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="263" mass="28970" checksum="24382FBA2533D646" modified="2005-04-12" version="1" fragment="single">LLYILCGNHIPIRMSMEGAKLVRVHPEKALEFPLVLYSSVTTPLILENITSSTVAFKIKTTAPRGYLVRPSSGLIQAGQSKEIQVILQPLQSVEQASPSHRFLIQTTACDSSVEQLTKDFWQDLSKEQLFEHRLSVIFKQENMGVNEPLSSSAVGTSSNASQGVPTSLISSAAGSSSSNTAQAGSMDSEFKNKYDELVQYCLALEKQSNELKEEVVSLREKLDKSESKLKSSNQGNIAQGFEFWHIIAMIIVAIVALKLINYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX79</accession>
    <name>Q5CX79_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">60S ribosomal protein L11</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd6_2170</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the universal ribosomal protein uL5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627575.1">
        <property type="nucleotide sequence ID" value="XM_627575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX79"/>
    <dbReference type="FunCoup" id="Q5CX79">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX79"/>
    <dbReference type="GeneID" id="3376168"/>
    <dbReference type="KEGG" id="cpv:cgd6_2170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2170"/>
    <dbReference type="InParanoid" id="Q5CX79"/>
    <dbReference type="OMA" id="NPMKELK"/>
    <dbReference type="OrthoDB" id="1734943at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1440.10:FF:000004">
        <property type="entry name" value="60S ribosomal protein L11, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1440.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002132">
        <property type="entry name" value="Ribosomal_uL5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031309">
        <property type="entry name" value="Ribosomal_uL5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022803">
        <property type="entry name" value="Ribosomal_uL5_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057266">
        <property type="entry name" value="Ribosomal_uL5_euk/arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031310">
        <property type="entry name" value="Ribosomal_uL5_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003258">
        <property type="entry name" value="PRK04219.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11994">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00281">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00673">
        <property type="entry name" value="Ribosomal_L5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002161">
        <property type="entry name" value="Ribosomal_L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55282">
        <property type="entry name" value="RL5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7 10 13" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL5 N-terminal" evidence="11">
        <location>
            <begin position="6"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Large ribosomal subunit protein uL5 C-terminal" evidence="12">
        <location>
            <begin position="63"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003930"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00281"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK89870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="172" mass="19636" checksum="BD526586A8712BF1" modified="2007-04-03" version="1">MTAEVNPMKNIKIEKLVINISVGQSGDRLTRAAKVLEQLTDQKPVFGQARFTIRSFSIRRAEKISCYVTVRGDKAEEILEKGLKVKEYELRKRNFSATGNFGFGIDEHIDLGIKYDPSTGIYGMDFFVQLTRPGNRVSLRRKCRSKVGKHGRVTKDEAMQWFQSKYDGIILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXD9</accession>
    <name>Q5CXD9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Protein with SET domain flanked by cysteine clusters plus a C-terminal PHD domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_1470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89820.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627515.1">
        <property type="nucleotide sequence ID" value="XM_627515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXD9"/>
    <dbReference type="STRING" id="353152.Q5CXD9"/>
    <dbReference type="GeneID" id="3376013"/>
    <dbReference type="KEGG" id="cpv:cgd6_1470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1470"/>
    <dbReference type="InParanoid" id="Q5CXD9"/>
    <dbReference type="OMA" id="RIRHIEC"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd10529">
        <property type="entry name" value="SET_SETD5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006560">
        <property type="entry name" value="AWS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050777">
        <property type="entry name" value="SET2_Histone-Lys_MeTrsfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22884">
        <property type="entry name" value="SET DOMAIN PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51215">
        <property type="entry name" value="AWS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="AWS" evidence="9">
        <location>
            <begin position="49"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="8">
        <location>
            <begin position="105"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89820.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="879" mass="103247" checksum="8EE14C31B7AE044D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXF8</accession>
    <name>Q5CXF8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_1250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627496.1">
        <property type="nucleotide sequence ID" value="XM_627496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXF8"/>
    <dbReference type="GeneID" id="3376040"/>
    <dbReference type="KEGG" id="cpv:cgd6_1250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1250"/>
    <dbReference type="InParanoid" id="Q5CXF8"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="534" mass="61979" checksum="0EE2B84231E98B52" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXG5</accession>
    <name>Q5CXG5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627489.1">
        <property type="nucleotide sequence ID" value="XM_627489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXG5"/>
    <dbReference type="GeneID" id="3376033"/>
    <dbReference type="KEGG" id="cpv:cgd6_1170"/>
    <dbReference type="InParanoid" id="Q5CXG5"/>
    <dbReference type="OrthoDB" id="342991at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="253" mass="28726" checksum="1845F06F7D79704B" modified="2005-04-12" version="1">MGSGSEVGFIAPTAEQNYNNLMEIAKGAKSVKVLEIHKNEVLSPVKEPNIKNYQNVVHGISEEKGAKIISPEIIEKQETNELKEKESEKLKEKKPDELKEKKSEKDILIKPEGSIPEKKEGKFLFKPFAEVARAVGIPAHSSYKEKSELHISFNGVLDSTTLLELYYFDYDRFVISRPILDGKEDAWISKSLLSLLYKSEQEEPLSFLMLSYGITSTHWQNFIPEEDLDAPETVVEEAIQEHDPSRGDIIFDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXH6</accession>
    <name>Q5CXH6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein with spectrin repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_1060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89791.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627478.1">
        <property type="nucleotide sequence ID" value="XM_627478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXH6"/>
    <dbReference type="GeneID" id="3376023"/>
    <dbReference type="KEGG" id="cpv:cgd6_1060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1060"/>
    <dbReference type="InParanoid" id="Q5CXH6"/>
    <dbReference type="OrthoDB" id="342153at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="262"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="21"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="202"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="500"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="262"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89791.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="558" mass="64033" checksum="37D7715D05D724CB" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXH7</accession>
    <name>Q5CXH7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Iron-sulfur cluster assembly protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_1050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>[2Fe-2S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:190135"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion matrix</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the NifU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627477.1">
        <property type="nucleotide sequence ID" value="XM_627477.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXH7"/>
    <dbReference type="FunCoup" id="Q5CXH7">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXH7"/>
    <dbReference type="GeneID" id="3376022"/>
    <dbReference type="KEGG" id="cpv:cgd6_1050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1050"/>
    <dbReference type="InParanoid" id="Q5CXH7"/>
    <dbReference type="OMA" id="SMVTEMV"/>
    <dbReference type="OrthoDB" id="1925777at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06664">
        <property type="entry name" value="IscU_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1010.10:FF:000013">
        <property type="entry name" value="Iron-sulfur cluster assembly enzyme ISCU, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1010.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011339">
        <property type="entry name" value="ISCU"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002871">
        <property type="entry name" value="NIF_FeS_clus_asmbl_NifU_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01999">
        <property type="entry name" value="iscU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10093">
        <property type="entry name" value="IRON-SULFUR CLUSTER ASSEMBLY ENZYME NIFU HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01592">
        <property type="entry name" value="NifU_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82649">
        <property type="entry name" value="SufE/NifU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0001">2Fe-2S</keyword>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0809">Transit peptide</keyword>
    <feature type="domain" description="NIF system FeS cluster assembly NifU N-terminal" evidence="3">
        <location>
            <begin position="26"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU362089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="150" mass="16613" checksum="AA869BDFEB7AED1A" modified="2007-04-03" version="1">MLQLRQLIDKRILIKKCVPICQRLFYSDTVHDHFRNPRNVGSLPSDDKNVGTAVVGKASCGDVVKLQVDIRDGIIKDAKFKTFGCGSAIASTSYATELIIGKTTEEALKINNKTIADHLNLPPIKLHCSLLAEDAIKHAIKNYQDKQLKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXK0</accession>
    <name>Q5CXK0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CpTSP9, extracellular protein with 3 TSP1 domains and an EGF domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90180.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627454.1">
        <property type="nucleotide sequence ID" value="XM_627454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXK0"/>
    <dbReference type="STRING" id="353152.Q5CXK0"/>
    <dbReference type="GeneID" id="3375996"/>
    <dbReference type="KEGG" id="cpv:cgd6_800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_800"/>
    <dbReference type="InParanoid" id="Q5CXK0"/>
    <dbReference type="OMA" id="FACNCTH"/>
    <dbReference type="OrthoDB" id="347314at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000019">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039942">
        <property type="entry name" value="SBSPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920">
        <property type="entry name" value="RPE-SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920:SF5">
        <property type="entry name" value="SMB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00008">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00022">
        <property type="entry name" value="EGF_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="6">
        <location>
            <begin position="355"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="4">
        <location>
            <begin position="382"/>
            <end position="391"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90180.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="457" mass="51722" checksum="50850F0DD6E14881" modified="2007-04-03" version="1">MLSCHIINGIILIGLLFFLRFDNISSQIADFRLPETRLCTNPYTFGFAIEQDTDIQLIDDDIWPLNQVFSAGGSISDNGFQILFATAKKNSYELIISVYPLLTTVVRECTYEGKVVRRLKSVVEHSPRFEKWPFFDKWVISFQRQEYGISISFNQGYTESLFWKRCLNEPIVSVKVESKDAYLSADQVDCIVSEWSSWSQCSSSCQIGTRSRTRLILRPASFEGTTCPNLIENEGCNTSISCEDCAYSSWSPWSECSVTCQGGFRSRTRKLIWKSDIKGRCEDNESDIESCNEQSCPVNCRLSSWTSWSICSSTCGPGNKMRYRIILAQSDLGGVQCPTEKEITERASCQLQECEKSCSTGEICKNGGTCIDIPNSGFSCECAEDYFGKFCEHKKYSWWVYFVFCIATQIIIGAIVKSTFLSRPAPITETPVTYNQEYAFNDYPTAFDQNTDISGVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXN3</accession>
    <name>Q5CXN3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">COPI associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_380</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627421.1">
        <property type="nucleotide sequence ID" value="XM_627421.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXN3"/>
    <dbReference type="GeneID" id="3376100"/>
    <dbReference type="KEGG" id="cpv:cgd6_380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_380"/>
    <dbReference type="InParanoid" id="Q5CXN3"/>
    <dbReference type="OMA" id="CSMETRD"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013714">
        <property type="entry name" value="Golgi_TVP15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28128:SF1">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08507">
        <property type="entry name" value="COPI_assoc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="48"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="102"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="147" mass="16913" checksum="8656B8979429AEA3" modified="2005-04-12" version="1">MSRKTSSESRKTTFKIFILQLLWIGFFIILILGGLSDLILFYDIKRMVLNVFIILSGIISLLAEAYCFKFYSYILFIYTPIGRGLFMAILSCLNLNENLYSLIISSILFLNSLIYLLISVIFGGINKPLFNNSLKHELNLRAQAIFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXV1</accession>
    <name>Q5CXV1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal peptide plus GPI anchored membrane protein with N-terminal multiple cysteines</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_4820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628629.1">
        <property type="nucleotide sequence ID" value="XM_628627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXV1"/>
    <dbReference type="STRING" id="353152.Q5CXV1"/>
    <dbReference type="GeneID" id="3372223"/>
    <dbReference type="KEGG" id="cpv:cgd7_4820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4820"/>
    <dbReference type="InParanoid" id="Q5CXV1"/>
    <dbReference type="OMA" id="ISTQWIK"/>
    <dbReference type="OrthoDB" id="341776at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255072" evidence="3">
        <location>
            <begin position="20"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="303"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="395" mass="45223" checksum="38B6B1C508DB422D" modified="2005-04-12" version="1">MWAIFKLIWLFSQFYLTFASNAKTTRLFGLTPEEQCKNFGCKTANNPNYYTSCGQSVFCSQCLLNSFKPLTHICGGWNLGKFERILLANGSIYSNSKISGNTFEDLSADWGENEPIDLSKCQLENFNYNSAYSAFSTGSYTSLYSTVTFNIAVLINKPKGKTIPPIEFQIDLDETLEEINMRGMNVRASRGNSLCPITHNLNPLKLKHKKTKETMTMISRSFSLPLDRSGVYRPYEFKVKAKCKEKKSCDMRFYKFCLRLSCSRMLESQLAQYKIVQGLLKDYPGNTVQQEEYEDEEDFEEFEHGRVSKNAQSSNKEDEDKDEAEKNYKYTEKVQISRKVPREVSRELQLGRQIVFSGKPPNSLQSFLSSNTFYLVLGFGALLVLAVLCFLLIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXW1</accession>
    <name>Q5CXW1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628619.1">
        <property type="nucleotide sequence ID" value="XM_628617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXW1"/>
    <dbReference type="GeneID" id="3372195"/>
    <dbReference type="KEGG" id="cpv:cgd7_4710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4710"/>
    <dbReference type="InParanoid" id="Q5CXW1"/>
    <dbReference type="OMA" id="RCSKIVF"/>
    <dbReference type="OrthoDB" id="339297at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="2">
        <location>
            <begin position="157"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="331" mass="36939" checksum="EABDA7C4352FF6DB" modified="2005-04-12" version="1">MWDLLSGVNGTNSVSNKLEKKTTENQGTSSPNQTRCATRNTTSEYPSNVASNGAIIGERLEVVYPKTEREKVLYQEYIQKTQEALNSFLSVIEDFNVAQESESNFKALGSCQKTPQVHVNLGNMGDALCSRFDSSSSKSEDALSTYVGKCSFGTSLTPKQIFDFMINVENKPLYDSTCAESSIIYYLGHLALAKQCYRGMMGVQGREFLIMGRNFTLSDNCYALVASSVSDTKNLTESEEEIPVTESYVRGEIKFVGFLIRQFKGETELFFAQKMDLGGSVPLMLQRIVLATQLQSLNALKKHLLDNIDLYFSQDKEDEISESSSTREEDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXX0</accession>
    <name>Q5CXX0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Divergent membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_4610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628610.1">
        <property type="nucleotide sequence ID" value="XM_628608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXX0"/>
    <dbReference type="GeneID" id="3372187"/>
    <dbReference type="KEGG" id="cpv:cgd7_4610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4610"/>
    <dbReference type="InParanoid" id="Q5CXX0"/>
    <dbReference type="OMA" id="PFNHIER"/>
    <dbReference type="OrthoDB" id="361691at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043198">
        <property type="entry name" value="Cyclin/Ssn8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10026">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="355" mass="40964" checksum="B59501FD4056E0DC" modified="2005-04-12" version="1">MKIFLQNERKKCNDKFSPFYTELPILLLRFQPTTLRISTLGILETLETCGAKHLIILILVKFVKMNVKSASQPELWQLARNSSGYRELLLGTSKLATVLCTNLHLSPGTTLTSCHYIYKFWSKFDILETDRKFIAAAAVLLSWKVREDIEPTRSSRKLSELSRFLYRIIKANSLSQVSSAPIPLELSSSFWIYKDSGKEYTHYMEQIKTYEFALLRAINFDLVPIELPFSHIERFTRILLYSPKLNEYVEEGEEGEEEGKEFESLKMFRLLASTISQDFYRLPNVCMQYNALEVSLCSVWYAGIFLSMSFAYEEISGSNQSWISKACPEVNAERVVRCMDECSKVLIWLINSDSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY01</accession>
    <name>Q5CY01_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_4250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628579.1">
        <property type="nucleotide sequence ID" value="XM_628577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY01"/>
    <dbReference type="STRING" id="353152.Q5CY01"/>
    <dbReference type="DNASU" id="3372081"/>
    <dbReference type="GeneID" id="3372081"/>
    <dbReference type="KEGG" id="cpv:cgd7_4250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4250"/>
    <dbReference type="InParanoid" id="Q5CY01"/>
    <dbReference type="OMA" id="TISEYEH"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17729">
        <property type="entry name" value="BRCT_CTDP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.10">
        <property type="entry name" value="S15/NS1, RNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="9">
        <location>
            <begin position="169"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="domain" description="BRCT" evidence="8">
        <location>
            <begin position="413"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="50"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="51"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="595" mass="66353" checksum="C6F876F2FF56F4C3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY08</accession>
    <name>Q5CY08_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Extracellular protein with a signal peptide followed by family 2 glycosyltransferase and ricin domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd7_4160</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628572.1">
        <property type="nucleotide sequence ID" value="XM_628570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY08"/>
    <dbReference type="STRING" id="353152.Q5CY08"/>
    <dbReference type="GeneID" id="3372074"/>
    <dbReference type="KEGG" id="cpv:cgd7_4160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4160"/>
    <dbReference type="InParanoid" id="Q5CY08"/>
    <dbReference type="OMA" id="IGCKLGF"/>
    <dbReference type="OrthoDB" id="416652at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027791">
        <property type="entry name" value="Galactosyl_T_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF126">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02709">
        <property type="entry name" value="Glyco_transf_7C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5" id="KW-0430">Lectin</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="12">
        <location>
            <begin position="177"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="domain" description="Galactosyltransferase C-terminal" evidence="14">
        <location>
            <begin position="348"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="13">
        <location>
            <begin position="493"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK90398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="637" mass="72521" checksum="AB5891760F92D26D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY63</accession>
    <name>Q5CY63_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_3540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628517.1">
        <property type="nucleotide sequence ID" value="XM_628515.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY63"/>
    <dbReference type="GeneID" id="3371983"/>
    <dbReference type="KEGG" id="cpv:cgd7_3540"/>
    <dbReference type="InParanoid" id="Q5CY63"/>
    <dbReference type="OMA" id="YHYNETQ"/>
    <dbReference type="OrthoDB" id="341115at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="403"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="522" mass="59141" checksum="084D20B21B4944F1" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY84</accession>
    <name>Q5CY84_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">E3 ubiquitin-protein ligase CHFR</fullName>
            <ecNumber evidence="4">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd7_3320</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the CHFR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628496.1">
        <property type="nucleotide sequence ID" value="XM_628494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY84"/>
    <dbReference type="STRING" id="353152.Q5CY84"/>
    <dbReference type="GeneID" id="3372048"/>
    <dbReference type="KEGG" id="cpv:cgd7_3320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3320"/>
    <dbReference type="InParanoid" id="Q5CY84"/>
    <dbReference type="OMA" id="YNIEETH"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006302">
        <property type="term" value="P:double-strand break repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051657">
        <property type="entry name" value="RNF168/RNF169_E3_ubiq-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23328">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23328:SF0">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="9 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="80"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="14">
        <location>
            <begin position="573"/>
            <end position="647"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00017908"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK90333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="873" mass="99450" checksum="FD39DDB1977145B7" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYB8</accession>
    <name>Q5CYB8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">ethanolamine-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="10">2.7.7.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">CTP:phosphoethanolamine cytidylyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_2950</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="9">Phospholipid metabolism; phosphatidylethanolamine biosynthesis; phosphatidylethanolamine from ethanolamine: step 2/3.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.14" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628462.1">
        <property type="nucleotide sequence ID" value="XM_628460.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYB8"/>
    <dbReference type="FunCoup" id="Q5CYB8">
        <property type="interactions" value="148"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYB8"/>
    <dbReference type="GeneID" id="3371975"/>
    <dbReference type="KEGG" id="cpv:cgd7_2950"/>
    <dbReference type="InParanoid" id="Q5CYB8"/>
    <dbReference type="OMA" id="FESNNWV"/>
    <dbReference type="OrthoDB" id="40021at2759"/>
    <dbReference type="UniPathway" id="UPA00558">
        <property type="reaction ID" value="UER00742"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004306">
        <property type="term" value="F:ethanolamine-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02173">
        <property type="entry name" value="ECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044608">
        <property type="entry name" value="Ect1/PCYT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45780:SF2">
        <property type="entry name" value="ETHANOLAMINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="18"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Cytidyltransferase-like" evidence="12">
        <location>
            <begin position="220"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00024221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00031473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK90627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="405" mass="46008" checksum="1906BEDC11C21B9A" modified="2005-04-12" version="1" fragment="single">LKLINMNTKNSNNSRIFVDGVFDLMHAGHFNALRKAKQFGNELVVGINSDLDCFNLKGCYPIYNQDERGELMKGCKWADEIVIGTPYIVEGSLLNQLNCEFVAHGDDLVLCSDGTDPYNEPRILGRLKIFQRTEGVSTTSVMTRIFRVLGLELEDILPLNKFDNSGMNGKENFIASKIDKFLDGDYSPCQSLISASRVLSFACGIASAKQVYNSNPNVTYIDGSFDIFHIGHLRFLERVKKIFGGVLIIGIYDDSTAQLIYGDGFPILKMMERALTLLSMRVVDDVIFGAPIKITKKLIETYKINNVVSCKIIENYVSSEHLKKNNFDSENSAEYASKLEEFCYEIPKKMGIFCNTTILKKEEICTNRDIFSRIMNRRDSILYVIKKRWAKELSFYENEVNTKLH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYJ6</accession>
    <name>Q5CYJ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large membrane associated channel</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628384.1">
        <property type="nucleotide sequence ID" value="XM_628382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYJ6"/>
    <dbReference type="GeneID" id="3371887"/>
    <dbReference type="KEGG" id="cpv:cgd7_2070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2070"/>
    <dbReference type="InParanoid" id="Q5CYJ6"/>
    <dbReference type="OMA" id="IATCMER"/>
    <dbReference type="OrthoDB" id="339281at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1050" mass="122203" checksum="BDC0EB359DA775D6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYK2</accession>
    <name>Q5CYK2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_2010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628378.1">
        <property type="nucleotide sequence ID" value="XM_628376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYK2"/>
    <dbReference type="GeneID" id="3371884"/>
    <dbReference type="KEGG" id="cpv:cgd7_2010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2010"/>
    <dbReference type="InParanoid" id="Q5CYK2"/>
    <dbReference type="OMA" id="IHSINMA"/>
    <dbReference type="OrthoDB" id="341720at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057600">
        <property type="entry name" value="TORTIFOLIA1/SINE1-2_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24714">
        <property type="entry name" value="TOR1L1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TORTIFOLIA1/SINE1-2 N-terminal" evidence="3">
        <location>
            <begin position="16"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="401"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="521"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="430"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="637" mass="71581" checksum="F63322FFC1790F37" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYK6</accession>
    <name>Q5CYK6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Nuclear pore associated protein (NLP4) with N-terminal ubiquitin domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_1970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_628372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYK6"/>
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    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYK6"/>
    <dbReference type="GeneID" id="3371796"/>
    <dbReference type="KEGG" id="cpv:cgd7_1970"/>
    <dbReference type="InParanoid" id="Q5CYK6"/>
    <dbReference type="OMA" id="MYGYYKE"/>
    <dbReference type="OrthoDB" id="10251089at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd08061">
        <property type="entry name" value="MPN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd17055">
        <property type="entry name" value="Ubl_AtNPL4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016563">
        <property type="entry name" value="Npl4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007717">
        <property type="entry name" value="NPL4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024682">
        <property type="entry name" value="Npl4_Ub-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007716">
        <property type="entry name" value="NPL4_Zn-bd_put"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12710:SF0">
        <property type="entry name" value="NUCLEAR PROTEIN LOCALIZATION PROTEIN 4 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05021">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11543">
        <property type="entry name" value="UN_NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05020">
        <property type="entry name" value="zf-NPL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF010052">
        <property type="entry name" value="Polyub_prc_Npl4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="2"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="NPL4 zinc-binding putative" evidence="2">
        <location>
            <begin position="165"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Nuclear pore localisation protein NPL4 C-terminal" evidence="3">
        <location>
            <begin position="214"/>
            <end position="478"/>
        </location>
    </feature>
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        <location>
            <begin position="88"/>
            <end position="132"/>
        </location>
    </feature>
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        <location>
            <begin position="88"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="109"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF05021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF11543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="491" mass="55259" checksum="48DA72F5F5E3E4F5" modified="2005-04-12" version="1" fragment="single">IMHEEWIIRVFSSSGRSRVTIPSTCNLSMLKSKIAQSLKVPEEQQLLSLDSHGNTLLKGDSLSVLQHGLFNGSIVYLITDATPQIATQSIQRPKHMTTSDLPPLEKKPSNSNYPSSSSADSKDMNNSVEKSEGPHFKSFDSFLSERNFVTDDLPLKQSYKSFFISKGVMNKIPPSVTLRHQAYRHVDHLEMMNLSEAMQFVDYWRSKLGMMKQRVGWMYGYYREDSTYPMGIRAVMEAIYEPPQDEKAEPGKLILENDSFKSTVDRVAQSLGLECLGLVFTHNERDEVLTSNEIVTLGKLQLEALKTPHYTGYPVSSFICCTIAPCKSIQGGDPIPNAFAVSDLGLALLRDKIIDEKGLKDDTHIVIREEDKGEILPQILEKGVSTRKFDAHWLIVRINESAPIQPKPFFSSSQFPRENRIVPQKPSDVSEFIKSRLTSVPLTSCNLLNDFHLLLYLAKLFDEATAISICESIINKTAVDQHLLDILMSLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYP6</accession>
    <name>Q5CYP6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_1510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628334.1">
        <property type="nucleotide sequence ID" value="XM_628332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYP6"/>
    <dbReference type="GeneID" id="3372251"/>
    <dbReference type="KEGG" id="cpv:cgd7_1510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1510"/>
    <dbReference type="InParanoid" id="Q5CYP6"/>
    <dbReference type="OrthoDB" id="342308at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="382"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="422"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="747"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="775"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="513"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="383"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="444"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="699"/>
            <end position="713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="783"/>
            <end position="793"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="798"/>
            <end position="812"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="931" mass="106009" checksum="1B8B6ED77C7C51FB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYR7</accession>
    <name>Q5CYR7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_1280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628313.1">
        <property type="nucleotide sequence ID" value="XM_628311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYR7"/>
    <dbReference type="STRING" id="353152.Q5CYR7"/>
    <dbReference type="GeneID" id="3371857"/>
    <dbReference type="KEGG" id="cpv:cgd7_1280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1280"/>
    <dbReference type="InParanoid" id="Q5CYR7"/>
    <dbReference type="OMA" id="MIKASMI"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254410" evidence="2">
        <location>
            <begin position="20"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="155"/>
            <end position="168"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="187" mass="20218" checksum="0C1A674B1D730C96" modified="2005-04-12" version="1">MRFYLFFFALLVFFVATNAVRIRGGEQNKLESETPEETTTTTTTTAQPDSTSDEDTTTTTTTTTTTTTTTTTTTTTTEAPEPVETKEGEETDENTDETTTTTTTASPKPKSPSYKDRLLSFFGSNGGSMFGLGKSSTTTTTTTAPVSSEDNKPEDSEDEKESESESDSSNEGSSNSEDSEEKTRKTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYY2</accession>
    <name>Q5CYY2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_580</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90541.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628248.1">
        <property type="nucleotide sequence ID" value="XM_628246.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYY2"/>
    <dbReference type="GeneID" id="3371916"/>
    <dbReference type="KEGG" id="cpv:cgd7_580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_580"/>
    <dbReference type="InParanoid" id="Q5CYY2"/>
    <dbReference type="OMA" id="NTNNIER"/>
    <dbReference type="OrthoDB" id="343282at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90541.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1055" mass="119434" checksum="71022CA635BEF19E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPM4</accession>
    <name>A3FPM4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative patched family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_850</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388370.1">
        <property type="nucleotide sequence ID" value="XM_001388333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPM4"/>
    <dbReference type="GeneID" id="3371869"/>
    <dbReference type="KEGG" id="cpv:cgd7_850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_850"/>
    <dbReference type="InParanoid" id="A3FPM4"/>
    <dbReference type="OMA" id="STHICHT"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF92">
        <property type="entry name" value="PATCHED-RELATED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="397"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="429"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="462"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="501"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="905"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1128"/>
            <end position="1145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1152"/>
            <end position="1173"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1218"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1254"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="4">
        <location>
            <begin position="396"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="676"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="753"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="829"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="834"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1280" mass="144235" checksum="BF8FF6A9C5C89755" modified="2007-04-03" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPR5</accession>
    <name>A3FPR5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein S4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_4760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388411.1">
        <property type="nucleotide sequence ID" value="XM_001388374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPR5"/>
    <dbReference type="FunCoup" id="A3FPR5">
        <property type="interactions" value="255"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPR5"/>
    <dbReference type="GeneID" id="3371813"/>
    <dbReference type="KEGG" id="cpv:cgd7_4760"/>
    <dbReference type="InParanoid" id="A3FPR5"/>
    <dbReference type="OMA" id="CIVTIRD"/>
    <dbReference type="OrthoDB" id="1109245at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06087">
        <property type="entry name" value="KOW_RPS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.740:FF:000001">
        <property type="entry name" value="40S ribosomal protein S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000051">
        <property type="entry name" value="40S ribosomal protein S4, X isoform"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00485">
        <property type="entry name" value="Ribosomal_eS4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000876">
        <property type="entry name" value="Ribosomal_eS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032277">
        <property type="entry name" value="Ribosomal_eS4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013845">
        <property type="entry name" value="Ribosomal_eS4_central_region"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038237">
        <property type="entry name" value="Ribosomal_eS4_central_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041982">
        <property type="entry name" value="Ribosomal_eS4_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013843">
        <property type="entry name" value="Ribosomal_eS4_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018199">
        <property type="entry name" value="Ribosomal_eS4_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581">
        <property type="entry name" value="30S/40S RIBOSOMAL PROTEIN S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11581:SF0">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16121">
        <property type="entry name" value="40S_S4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00467">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00900">
        <property type="entry name" value="Ribosomal_S4e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08071">
        <property type="entry name" value="RS4NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002116">
        <property type="entry name" value="Ribosomal_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00528">
        <property type="entry name" value="RIBOSOMAL_S4E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="7">
        <location>
            <begin position="41"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="260" mass="28987" checksum="B4CFCE62D64200AB" modified="2007-04-03" version="1" fragment="single">ARGPKKHLKRVAAPSNWMLDKLTGVYAPRPSSGPHKLRECIPLAILLRNRLKFALTYTEAKYIVMQRLIKVDGKVRTDICFPLGLMDVVSIDRVGKNIRIMYDTKGRFVPVQIDSKEAGFKLCKVTKVALGAKGIPTATTNDARTLRYIHPDVKANDTVKVDLATGKVIDFVKCEVGNMCMVTGGRSQGRVGTITHFERKMGAQCIVTIRDQKGATFATLMKNIFVIGEEGKPLVTLPKDKGIRLSNVEDRNLRMKKHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPS0</accession>
    <name>A3FPS0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Acetyl-coenzyme A transporter 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388299.1">
        <property type="nucleotide sequence ID" value="XM_001388262.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A3FPS0">
        <property type="interactions" value="77"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPS0"/>
    <dbReference type="GeneID" id="3375924"/>
    <dbReference type="KEGG" id="cpv:cgd6_470"/>
    <dbReference type="InParanoid" id="A3FPS0"/>
    <dbReference type="OMA" id="ICTTSWI"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008521">
        <property type="term" value="F:acetyl-CoA transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035348">
        <property type="term" value="P:acetyl-CoA transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024371">
        <property type="entry name" value="AcetylCoA_trans_1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004752">
        <property type="entry name" value="AmpG_permease/AT-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778:SF9">
        <property type="entry name" value="ACETYL-COENZYME A TRANSPORTER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12778">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 33 ACETYL-COA TRANSPORTER -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13000">
        <property type="entry name" value="Acatn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="9"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="75"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="114"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="206"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="260"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="305"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="377"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="451" mass="51555" checksum="929A1FFA787CCE38" modified="2007-04-03" version="1">MDLLECLNIFYLLILYTIQGLPMGISYSIPFLLQGKISYTEQSMFGMVVLPFSLKLLWAPLVDSVYIEKMGRRKTWIIPTQLVCSILMIIGSYSPFLPTWLCEEVGISNLTEKLSPNVTLLTIYFSTLYFLMATQDIAVDAWAVNLLSPQHKSLASTCNIIGQSFGHITSYLGFLFLNDPKVCNKYVRPLLGLEIVDKPICKMSQFIYFWGVVILLVTIITGILKKEDNSYTNVIDNKKDDDAAQEDQEAELTIKEAYSLLYKILTLKPVISLIILLFIIRIPSAITDSSLEFKLMEFGMKKSEIMLIGPILIPFSFITPFIMTKFVYKGKSPLKFLTIILPLKLILSLFFCLLLIWSRIIYKPWINTEEVADTPNLFYYTYLALSICSSILCDSQSLIFMTLFNLISXXQXCWNLHLAXXRDXXKRIXDINGQKVLVYGFWIIQTINTVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPT9</accession>
    <name>A3FPT9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Kinesin heavy chain, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_1900</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388318.1">
        <property type="nucleotide sequence ID" value="XM_001388281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPT9"/>
    <dbReference type="SMR" id="A3FPT9"/>
    <dbReference type="STRING" id="353152.A3FPT9"/>
    <dbReference type="GeneID" id="3375943"/>
    <dbReference type="KEGG" id="cpv:cgd6_1900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1900"/>
    <dbReference type="InParanoid" id="A3FPT9"/>
    <dbReference type="OMA" id="CCHVAND"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005875">
        <property type="term" value="C:microtubule associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051231">
        <property type="term" value="P:spindle elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01376">
        <property type="entry name" value="KISc_KID_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969">
        <property type="entry name" value="CHROMOSOME-ASSOCIATED KINESIN KIF4A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47969:SF29">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0505">Motor protein</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="3">
        <location>
            <begin position="66"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="631"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="679"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="631"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="binding site" evidence="1">
        <location>
            <begin position="154"/>
            <end position="161"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="714" mass="79329" checksum="01EA86151583B3A5" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPU8</accession>
    <name>A3FPU8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA dimethylallyltransferase</fullName>
            <ecNumber evidence="3">2.5.1.75</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_2540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13 14">
            <text>adenosine(37) in tRNA + dimethylallyl diphosphate = N(6)-dimethylallyladenosine(37) in tRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:26482"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10375"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57623"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74415"/>
            <dbReference type="EC" id="2.5.1.75"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the IPP transferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.75" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388327.1">
        <property type="nucleotide sequence ID" value="XM_001388290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPU8"/>
    <dbReference type="FunCoup" id="A3FPU8">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPU8"/>
    <dbReference type="GeneID" id="3375952"/>
    <dbReference type="KEGG" id="cpv:cgd6_2540"/>
    <dbReference type="InParanoid" id="A3FPU8"/>
    <dbReference type="OMA" id="WGLHLKS"/>
    <dbReference type="OrthoDB" id="775260at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052381">
        <property type="term" value="F:tRNA dimethylallyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00185">
        <property type="entry name" value="IPP_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039657">
        <property type="entry name" value="Dimethylallyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018022">
        <property type="entry name" value="IPT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00174">
        <property type="entry name" value="miaA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11088:SF60">
        <property type="entry name" value="TRNA DIMETHYLALLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01715">
        <property type="entry name" value="IPPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="361" mass="42109" checksum="EF150282469047DF" modified="2007-04-03" version="1" fragment="single">CVASGKTRLSIDIWKYLDKKGFKSEIINCDSMQLYKGFDIGTAKVSKEIRNRIPHHLLDVFDIDEDCTASKYISIAVPIIDRLISENVTPIIVGGTHMYLKALIWKSIIDSETCSSVNPSIKDEEYSNFTNEELLEQLSKIDPERALSLNINDRRKIIRGIEIYNTNGLTFTELKKIHPYKVRYNNSVLFWVRNNNIRECIDIRINEMINDGLLKEVFLLKERLLTCNKYIGLLQGIAYKEFIDILDKKTKIEDISEEELNICIENLRIKTFQYSKRQEKFIKKHIINRGLNVNILEFDGEVSDSQKLELLEFNFQSTSIIYKYLSKLFNLKNNSESKQVYSSWEKSVLTRAFMILDKKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPV2</accession>
    <name>A3FPV2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd6_2790</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9 10">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388331.1">
        <property type="nucleotide sequence ID" value="XM_001388294.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPV2"/>
    <dbReference type="SMR" id="A3FPV2"/>
    <dbReference type="STRING" id="353152.A3FPV2"/>
    <dbReference type="GeneID" id="3375957"/>
    <dbReference type="KEGG" id="cpv:cgd6_2790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2790"/>
    <dbReference type="InParanoid" id="A3FPV2"/>
    <dbReference type="OMA" id="DMIRVMK"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23649">
        <property type="entry name" value="Khc_CBD_cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01369">
        <property type="entry name" value="KISc_KHC_KIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059182">
        <property type="entry name" value="Khc_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968">
        <property type="entry name" value="CENTROMERE PROTEIN E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47968:SF17">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="7 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="29"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="622"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="556"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="118"/>
            <end position="125"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAZ51525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="757" mass="85119" checksum="0AE835D8DACE7FB6" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ03</accession>
    <name>A3FQ03_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd8_4470</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the SEC23/SEC24 family. SEC24 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388444.1">
        <property type="nucleotide sequence ID" value="XM_001388407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ03"/>
    <dbReference type="FunCoup" id="A3FQ03">
        <property type="interactions" value="288"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ03"/>
    <dbReference type="GeneID" id="3374357"/>
    <dbReference type="KEGG" id="cpv:cgd8_4470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4470"/>
    <dbReference type="InParanoid" id="A3FQ03"/>
    <dbReference type="OMA" id="AVECSKQ"/>
    <dbReference type="OrthoDB" id="49016at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070971">
        <property type="term" value="C:endoplasmic reticulum exit site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090110">
        <property type="term" value="P:COPII-coated vesicle cargo loading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1670">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.730">
        <property type="entry name" value="Sec23/Sec24 helical domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.20.10">
        <property type="entry name" value="Severin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.380">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029006">
        <property type="entry name" value="ADF-H/Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012990">
        <property type="entry name" value="Beta-sandwich_Sec23_24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007123">
        <property type="entry name" value="Gelsolin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036180">
        <property type="entry name" value="Gelsolin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006900">
        <property type="entry name" value="Sec23/24_helical_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036175">
        <property type="entry name" value="Sec23/24_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006896">
        <property type="entry name" value="Sec23/24_trunk_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050550">
        <property type="entry name" value="SEC23_SEC24_subfamily"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006895">
        <property type="entry name" value="Znf_Sec23_Sec24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036174">
        <property type="entry name" value="Znf_Sec23_Sec24_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803">
        <property type="entry name" value="SEC24-RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13803:SF39">
        <property type="entry name" value="SECRETORY 24AB, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00626">
        <property type="entry name" value="Gelsolin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08033">
        <property type="entry name" value="Sec23_BS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04815">
        <property type="entry name" value="Sec23_helical"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04811">
        <property type="entry name" value="Sec23_trunk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04810">
        <property type="entry name" value="zf-Sec23_Sec24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81995">
        <property type="entry name" value="beta-sandwich domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82754">
        <property type="entry name" value="C-terminal, gelsolin-like domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81811">
        <property type="entry name" value="Helical domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82919">
        <property type="entry name" value="Zn-finger domain of Sec23/24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0653">Protein transport</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Zinc finger Sec23/Sec24-type" evidence="14">
        <location>
            <begin position="197"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 trunk" evidence="15">
        <location>
            <begin position="271"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 beta-sandwich" evidence="17">
        <location>
            <begin position="521"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Sec23/Sec24 helical" evidence="16">
        <location>
            <begin position="618"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="domain" description="Gelsolin-like" evidence="13">
        <location>
            <begin position="734"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="50"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="16"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="53"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004586"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF04810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF08033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAZ51484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="874" mass="97377" checksum="BCF067DA7114C9F5" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQE5</accession>
    <name>A3FQE5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Serine/threonine-protein phosphatase 2A activator</fullName>
            <ecNumber evidence="7">5.2.1.8</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Phosphotyrosyl phosphatase activator</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_2470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 7">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 7">Belongs to the PTPA-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388167.1">
        <property type="nucleotide sequence ID" value="XM_001388130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQE5"/>
    <dbReference type="FunCoup" id="A3FQE5">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQE5"/>
    <dbReference type="GeneID" id="3371402"/>
    <dbReference type="KEGG" id="cpv:cgd1_2470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2470"/>
    <dbReference type="InParanoid" id="A3FQE5"/>
    <dbReference type="OMA" id="IHESQDV"/>
    <dbReference type="OrthoDB" id="16120at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008160">
        <property type="term" value="F:protein tyrosine phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04087">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1150:FF:000002">
        <property type="entry name" value="Serine/threonine-protein phosphatase 2A activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004327">
        <property type="entry name" value="Phstyr_phstse_ac"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043170">
        <property type="entry name" value="PTPA_C_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037218">
        <property type="entry name" value="PTPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE 2A REGULATORY SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10012:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 2A ACTIVATOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03095">
        <property type="entry name" value="PTPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016325">
        <property type="entry name" value="Phstyr_phstse_ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140984">
        <property type="entry name" value="PTPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0697">Rotamase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="316" mass="36547" checksum="C7579CB490FF0E30" modified="2007-04-03" version="1">MSLAERVECIAKITDLTQLNYFICGKTHSDIIDFIKLLSESIKGKILVQQHEYEESGKERSDIGFNSIINILKLLSKLDSNIDEIPPIKQPMRFGNKAFQTWYDKTNQTCTSYISDILKENSDEYLQEVKSYFVESFGNRSRVDYGTGHELNFILFLMCIHRLGAFQKNDLPDLILVVFYRYILLMRRLQSIYLLEPAGSRGVWGLDDYQFLPFLFGSAQLINSNELFPVLTNQILDRSILEIYSAKSLYINSIQHILNMKTNVYFAECSPILYSLTSVPTWEKIYSGMIKMYVAEILNKFPVAQHILFGSLIPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQI7</accession>
    <name>A3FQI7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Dolichol-phosphate mannosyltransferase subunit 1</fullName>
            <ecNumber evidence="13">2.4.1.83</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd5_2040</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>a di-trans,poly-cis-dolichyl phosphate + GDP-alpha-D-mannose = a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate + GDP</text>
            <dbReference type="Rhea" id="RHEA:21184"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19501"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58211"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="5 13">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="13">Component of the dolichol-phosphate mannose (DPM) synthase complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4 13">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6 13">Belongs to the glycosyltransferase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.83" evidence="13"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388271.1">
        <property type="nucleotide sequence ID" value="XM_001388234.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQI7"/>
    <dbReference type="SMR" id="A3FQI7"/>
    <dbReference type="FunCoup" id="A3FQI7">
        <property type="interactions" value="398"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQI7"/>
    <dbReference type="GeneID" id="3373355"/>
    <dbReference type="KEGG" id="cpv:cgd5_2040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2040"/>
    <dbReference type="InParanoid" id="A3FQI7"/>
    <dbReference type="OMA" id="KCFRREV"/>
    <dbReference type="OrthoDB" id="2603at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004582">
        <property type="term" value="F:dolichyl-phosphate beta-D-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006066">
        <property type="term" value="P:alcohol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006720">
        <property type="term" value="P:isoprenoid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035269">
        <property type="term" value="P:protein O-linked glycosylation via mannose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06442">
        <property type="entry name" value="DPM1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000036">
        <property type="entry name" value="Dolichol-phosphate mannosyltransferase subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039528">
        <property type="entry name" value="DPM1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43398:SF1">
        <property type="entry name" value="DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 13" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0464">Manganese</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="14">
        <location>
            <begin position="9"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00006739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU365083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAZ51293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="242" mass="27598" checksum="640A0782BBE8FCD5" modified="2007-04-03" version="1">MLKVSPMYSVIIPTYNERENVGIMVELLHETFSKLPVNWEIIIVDDSSPDGTAEVVEKLQKCYPEVNIKLVKRKGKLGLGTAYMKGFEHSEGDFIILMDCDLSHHPKYIADFIEKQETKDFDIVSGSRYIRNGGVSGWTWDRILVSRVANFLANFLLQPRASDLTGSFRLYKRDVFKSILGSNMVSKGYVFQMEIIARATKFGYSIADVPIVFVDRLYGDSKLGKNEIFGYIKGLLQLFWIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQI8</accession>
    <name>A3FQI8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DNA methyltransferase PMT1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_2100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388272.1">
        <property type="nucleotide sequence ID" value="XM_001388235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQI8"/>
    <dbReference type="STRING" id="353152.A3FQI8"/>
    <dbReference type="GeneID" id="3373354"/>
    <dbReference type="KEGG" id="cpv:cgd5_2100"/>
    <dbReference type="InParanoid" id="A3FQI8"/>
    <dbReference type="OMA" id="IDLACAN"/>
    <dbReference type="OrthoDB" id="414133at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.120.10">
        <property type="entry name" value="DNA Methylase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050750">
        <property type="entry name" value="C5-MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001525">
        <property type="entry name" value="C5_MeTfrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46098:SF1">
        <property type="entry name" value="TRNA (CYTOSINE(38)-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00145">
        <property type="entry name" value="DNA_methylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="303" mass="35256" checksum="B9D35DB30E7B8923" modified="2007-04-03" version="1" fragment="single">MLSLDGQNKLPKAWFVENVANFETSNTHKEMIKMLSKLNFCTFEFMLSPTLIGVPNTRVRYYCVSVRKDSANLIKQLNELKISIYQKNCQSIASNVLLSHSIEKNTEDFKPEKIPLEYSNLLCSLPYEYNQIIQMIDNIPNSISDVVMKSNDIDYESFNLLKQFAKNIIKNNPSFKFDIVNINSKASTTFTKSYIETKGRGGPLFDFSENHEKIEKSIIDYYDTYSHIFNTRILEHQRFQTARDNDNLRCFHPKEMLLIMGFPNNWFEGVNIDLKKQYSLIGNSISIHIVTILLHFMLELLVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQJ7</accession>
    <name>A3FQJ7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Cullin family profile domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_3100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388281.1">
        <property type="nucleotide sequence ID" value="XM_001388244.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQJ7"/>
    <dbReference type="GeneID" id="3373327"/>
    <dbReference type="KEGG" id="cpv:cgd5_3100"/>
    <dbReference type="InParanoid" id="A3FQJ7"/>
    <dbReference type="OrthoDB" id="343985at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264:SF3">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="5">
        <location>
            <begin position="1198"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="132"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="6">
        <location>
            <position position="1401"/>
        </location>
    </feature>
    <feature type="unsure residue" description="E or Q" evidence="6">
        <location>
            <position position="1404"/>
        </location>
    </feature>
    <feature type="unsure residue" description="I or L" evidence="6">
        <location>
            <position position="1407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1422" mass="163617" checksum="9C6783FAAB485C3B" modified="2013-05-29" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPE5</accession>
    <name>Q5CPE5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_4590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000017">
        <property type="protein sequence ID" value="EAK87296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625307.1">
        <property type="nucleotide sequence ID" value="XM_625307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPE5"/>
    <dbReference type="GeneID" id="3372309"/>
    <dbReference type="KEGG" id="cpv:cgd5_4590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4590"/>
    <dbReference type="InParanoid" id="Q5CPE5"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="172"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="209" mass="23546" checksum="DCE40BFC20A10406" modified="2005-04-12" version="1">MYLKSVILIFFLFINFLFLFENVTDNFLFKKDVSLIKIRNETPNEGSSSSGNSNKKCSSRGGGRGGGGSGGKKPVLKNVNLSKKGGAGNCSIYHHHHHHHHQLSSTPQTRDPSNLSSDPFDEPLDGPYQNSNNKNDNKEDEEEEEEEEEEEEEDHNRNENRQKGKKTDSNKKQRNGNNKKKKRRGGKDDLRGLLRGLSGSSKDILHDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPJ1</accession>
    <name>Q5CPJ1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625358.1">
        <property type="nucleotide sequence ID" value="XM_625358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPJ1"/>
    <dbReference type="STRING" id="353152.Q5CPJ1"/>
    <dbReference type="GeneID" id="3375639"/>
    <dbReference type="KEGG" id="cpv:cgd6_190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_190"/>
    <dbReference type="InParanoid" id="Q5CPJ1"/>
    <dbReference type="OMA" id="CNIALNI"/>
    <dbReference type="OrthoDB" id="339921at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="494"/>
            <end position="607"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="609" mass="71039" checksum="04AC8A1116BB85F4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPQ7</accession>
    <name>Q5CPQ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_4420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625457.1">
        <property type="nucleotide sequence ID" value="XM_625457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPQ7"/>
    <dbReference type="GeneID" id="3372440"/>
    <dbReference type="KEGG" id="cpv:cgd4_4420"/>
    <dbReference type="InParanoid" id="Q5CPQ7"/>
    <dbReference type="OrthoDB" id="344006at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="97"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="154" mass="17923" checksum="5AF79B2BE83E018F" modified="2005-04-12" version="1">MDSDSQESKPSRRKVLQRQNQEVKALKEQWKKALASCNKKGSKKELDKEYQSKMEALQLSHKMELMKLSGEGNLENEEDSVEQSSENNRNIDDSNTNKLSLVEKLQTMDEVPSLYSNATFQVTKSEKRKKKRQKELEQKYMKSLEECALNSKFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPY5</accession>
    <name>Q5CPY5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SWIM-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625494.1">
        <property type="nucleotide sequence ID" value="XM_625494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPY5"/>
    <dbReference type="GeneID" id="3372512"/>
    <dbReference type="KEGG" id="cpv:cgd8_310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_310"/>
    <dbReference type="InParanoid" id="Q5CPY5"/>
    <dbReference type="OrthoDB" id="337581at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097196">
        <property type="term" value="C:Shu complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28498:SF1">
        <property type="entry name" value="ZINC FINGER SWIM DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="88"/>
            <end position="137"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="230" mass="26607" checksum="47A334251DD40AF8" modified="2005-04-12" version="1">MSCMLKYCTIKNQDHINSLLCLVSELKPVNARLDFQPEDHENSIMDFNLKILQTISEIYPGLVEKAISLIDHGKIDVYIERKSCRRFYIMEATTKGQDMSYLVMRHFCTCHSYIDKVVLQKKEITCKHELAYYLLDSMYISDIIINSLDTDPKLYPESGYERGSVKKENEQVNKINQEEKVINLMGSSNPLIKVHLVSETMFSEVYLEYTSRFFIDSGLFKKIGGKNKGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ17</accession>
    <name>Q5CQ17_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large low complexity protein, possible apicomplexan-specific</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_4480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87592.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625609.1">
        <property type="nucleotide sequence ID" value="XM_625609.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ17"/>
    <dbReference type="GeneID" id="3372552"/>
    <dbReference type="KEGG" id="cpv:cgd5_4480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4480"/>
    <dbReference type="InParanoid" id="Q5CQ17"/>
    <dbReference type="OrthoDB" id="272810at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="193"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="896"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1180"/>
            <end position="1204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="193"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="224"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="261"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="898"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1182"/>
            <end position="1204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87592.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2253" mass="257982" checksum="2FF5C09315D92EA1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ65</accession>
    <name>Q5CQ65_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein with 3 transmembrane domains, ring domain, and possible signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_3970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625561.1">
        <property type="nucleotide sequence ID" value="XM_625561.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ65"/>
    <dbReference type="GeneID" id="3372604"/>
    <dbReference type="KEGG" id="cpv:cgd5_3970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3970"/>
    <dbReference type="InParanoid" id="Q5CQ65"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="218"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="310" mass="35744" checksum="6961BC77C8EB30F9" modified="2005-04-12" version="1">MRKYNGYFGICVLITTICFYATRLPYFDYQEDSNNSNSSGSSSSVNNNNNNQLEEENYRLKKRKIFIQHILSVISCCGFGFSLSGSVLLLSTRITSPWVNSCFITIISQSLDLLLRGYLGLIIDHHSFEEKKIRYYKYVFPSYLLKDEEKIHCNNNGQREWVVKCNYNSQPPPLIFKHSFISISLTKISSTFFSLNNFSNNEEQTDSQSNNASQTTNCMICYENPSNIVFSPCLHSGICDNCIDELMKWTVCKLKKIPCCHLCRSPIEIAWQLNPNESNSNENNYFSEKCTEVIYPKLQIYDDSNEKSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ75</accession>
    <name>Q5CQ75_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">YprA. Lhr1/Ski2 family RNA SFII helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_3870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625551.1">
        <property type="nucleotide sequence ID" value="XM_625551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ75"/>
    <dbReference type="STRING" id="353152.Q5CQ75"/>
    <dbReference type="GeneID" id="3372559"/>
    <dbReference type="KEGG" id="cpv:cgd5_3870"/>
    <dbReference type="InParanoid" id="Q5CQ75"/>
    <dbReference type="OMA" id="NIDFIHW"/>
    <dbReference type="OrthoDB" id="18781at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036297">
        <property type="term" value="P:interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47957:SF3">
        <property type="entry name" value="ATP-DEPENDENT HELICASE HRQ1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0347">Helicase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254400" evidence="3">
        <location>
            <begin position="18"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="275"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="516"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="851" mass="98508" checksum="1891EC62ADCF9D28" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ95</accession>
    <name>Q5CQ95_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625531.1">
        <property type="nucleotide sequence ID" value="XM_625531.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ95"/>
    <dbReference type="GeneID" id="3372539"/>
    <dbReference type="KEGG" id="cpv:cgd5_3650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3650"/>
    <dbReference type="InParanoid" id="Q5CQ95"/>
    <dbReference type="OMA" id="NRIRIMM"/>
    <dbReference type="OrthoDB" id="338280at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="145"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="304" mass="35001" checksum="EFCC5454CEB2ACD4" modified="2005-04-12" version="1">MTGELVSRLQRVRAQMDDHAVHYVGGGESSRADARNSVFKLKWKFATMPDKNKIKIAMDMHGHVLGEQDPSDDEAWGNWNTNKLKQCKMVGKLEQTKDIGSVLVSEFENVTKTEKEMEAKGLINTPYLNEKTETEKRDEILREEEASSSSDDEYSQKDKNGVQRFNTLQKEFMLQNLTEWYREIVKQYKEGIKLIKVAKSGKKFIRIVKLTDSGFFEISSVTSNSDRMVHLTDIKNIELGIDAPEFKECKKVNPKNPPVPGLSCVINLPDKKTLCLMFNDEEARNSFVFMIRVLKRKFENYKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQE3</accession>
    <name>Q5CQE3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_1080</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625705.1">
        <property type="nucleotide sequence ID" value="XM_625705.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQE3"/>
    <dbReference type="STRING" id="353152.Q5CQE3"/>
    <dbReference type="GeneID" id="3372674"/>
    <dbReference type="KEGG" id="cpv:cgd4_1080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1080"/>
    <dbReference type="InParanoid" id="Q5CQE3"/>
    <dbReference type="OMA" id="LIVYTHW"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02995">
        <property type="entry name" value="PDI_a_PDI_a'_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929">
        <property type="entry name" value="PROTEIN DISULFIDE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18929:SF132">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="9">
        <location>
            <begin position="546"/>
            <end position="675"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="679" mass="78478" checksum="1159D12C296F4CCB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQP5</accession>
    <name>Q5CQP5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_3820</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87748.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625957.1">
        <property type="nucleotide sequence ID" value="XM_625957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQP5"/>
    <dbReference type="STRING" id="353152.Q5CQP5"/>
    <dbReference type="GeneID" id="3372920"/>
    <dbReference type="KEGG" id="cpv:cgd4_3820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3820"/>
    <dbReference type="InParanoid" id="Q5CQP5"/>
    <dbReference type="OMA" id="VENAICT"/>
    <dbReference type="OrthoDB" id="340321at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87748.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="895" mass="102938" checksum="3CC6B2D1566CE576" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQR7</accession>
    <name>Q5CQR7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625935.1">
        <property type="nucleotide sequence ID" value="XM_625935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQR7"/>
    <dbReference type="GeneID" id="3372854"/>
    <dbReference type="KEGG" id="cpv:cgd4_3590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3590"/>
    <dbReference type="InParanoid" id="Q5CQR7"/>
    <dbReference type="OMA" id="NDIWRIG"/>
    <dbReference type="OrthoDB" id="337574at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="452"/>
            <end position="473"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="926" mass="108061" checksum="E0062F1242201EA0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQX9</accession>
    <name>Q5CQX9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87818.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625873.1">
        <property type="nucleotide sequence ID" value="XM_625873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQX9"/>
    <dbReference type="GeneID" id="3372996"/>
    <dbReference type="KEGG" id="cpv:cgd4_2880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2880"/>
    <dbReference type="InParanoid" id="Q5CQX9"/>
    <dbReference type="OMA" id="NEIRNTW"/>
    <dbReference type="OrthoDB" id="342911at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="145"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="256"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87818.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="436" mass="50843" checksum="C8543F8E1B3187E5" modified="2005-04-12" version="1">MVFQKENKNNNGWVANYDAHNTQLGSALFEITEKAAKVRTILEKKRRNEEICNLISSSNEQTLINNIKKEIARENQASFCKVADLIESKILDFSEQNKKCINVNIERSIEASNETIKISSAEIIEKLLSNIIKSNDLNSLNESLANLLLEQKDNINNSLKELINTINQKESRISQEVCELIRENGEKEKSIYLSQLNIIQRQYELIIRDLRRRIMFLERDIESKQIREKKLCEEIKSMDNNAKEAVLIFGEKDLKINFLSSQINQLKDENKELREEITILLNKKQEITMNYSSKYCLLKNKYLFLGIEFLHETLGKIISSRRKEVFNILKYNSEFNSINSNMNENSAMAYRDSNKYNINTQVRIKINESNLFGLLDVEKRIEEQEKERSLINALLSMINGHNFAQLASFTKIINQKRIEILTKIFTMLKNQKNISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR03</accession>
    <name>Q5CR03_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosome biogenesis protein NOP53</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625849.1">
        <property type="nucleotide sequence ID" value="XM_625849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR03"/>
    <dbReference type="GeneID" id="3372847"/>
    <dbReference type="KEGG" id="cpv:cgd4_2630"/>
    <dbReference type="InParanoid" id="Q5CR03"/>
    <dbReference type="OrthoDB" id="342649at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31960" checksum="0A59C2450A5F1C8C" modified="2005-04-12" version="1">MTMVQPKKKFRKIKLQDENYVWKRGSIERNIDDSLNSGKLFTFDTKILFNSRSNLDRKKKNCDTIKKRCKLKYFNKDGADASMSKRPLKKVRNLNPNELDIWGSSVSTSKSVNSGMNYPGELLRIKGPSIQMPHSGQSINPSEPDRQDALLRSSSVLNINTNSRNNAFPASLVNSFISSYYESDEVIKLTEPQKYHLVNSLLNGKVLGLDSIGDLELVSDTKDEIDNNSYSRQQNNGIRKKKSEINKEIRRKKELMFNKEKTRIKKLNKDVQNMGKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR72</accession>
    <name>Q5CR72_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625780.1">
        <property type="nucleotide sequence ID" value="XM_625780.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR72"/>
    <dbReference type="GeneID" id="3372899"/>
    <dbReference type="KEGG" id="cpv:cgd4_1860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1860"/>
    <dbReference type="InParanoid" id="Q5CR72"/>
    <dbReference type="OMA" id="ICIRSEN"/>
    <dbReference type="OrthoDB" id="342975at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="284"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="380"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="427"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="663" mass="75826" checksum="D157357F19C22ECD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR86</accession>
    <name>Q5CR86_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625766.1">
        <property type="nucleotide sequence ID" value="XM_625766.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR86"/>
    <dbReference type="GeneID" id="3372921"/>
    <dbReference type="KEGG" id="cpv:cgd4_1710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1710"/>
    <dbReference type="InParanoid" id="Q5CR86"/>
    <dbReference type="OMA" id="CRSINMN"/>
    <dbReference type="OrthoDB" id="436262at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000779">
        <property type="term" value="C:condensed chromosome, centromeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010032">
        <property type="term" value="P:meiotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026971">
        <property type="entry name" value="CND1/NCAPD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222">
        <property type="entry name" value="CONDENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14222:SF2">
        <property type="entry name" value="CONDENSIN COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1443"/>
            <end position="1466"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1466" mass="170625" checksum="4D2C89EE84832DC9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRB7</accession>
    <name>Q5CRB7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Nascent polypeptide associated complex alpha chain with an NAC domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_3450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626269.1">
        <property type="nucleotide sequence ID" value="XM_626269.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRB7"/>
    <dbReference type="FunCoup" id="Q5CRB7">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRB7"/>
    <dbReference type="GeneID" id="3373058"/>
    <dbReference type="KEGG" id="cpv:cgd5_3450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3450"/>
    <dbReference type="InParanoid" id="Q5CRB7"/>
    <dbReference type="OMA" id="SQKMIFA"/>
    <dbReference type="OrthoDB" id="3169036at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005854">
        <property type="term" value="C:nascent polypeptide-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22054">
        <property type="entry name" value="NAC_NACA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14358">
        <property type="entry name" value="UBA_NAC_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.30">
        <property type="entry name" value="Nascent polypeptide-associated complex domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016641">
        <property type="entry name" value="EGD2/NACA0like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044034">
        <property type="entry name" value="NAC-like_UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038187">
        <property type="entry name" value="NAC_A/B_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002715">
        <property type="entry name" value="Nas_poly-pep-assoc_cplx_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21713">
        <property type="entry name" value="NASCENT POLYPEPTIDE ASSOCIATED COMPLEX ALPHA SUBUNIT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01849">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19026">
        <property type="entry name" value="UBA_HYPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015901">
        <property type="entry name" value="NAC_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01407">
        <property type="entry name" value="NAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51151">
        <property type="entry name" value="NAC_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAC-A/B" evidence="2">
        <location>
            <begin position="41"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="38"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="146"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="196" mass="21096" checksum="BB211A53E14B7DBF" modified="2005-04-12" version="1">MVGEQEPKIVEIHDDQISSGESSEDEDLNSGKTEGVRPRHNKGEKKNRKLVQKLGLKPLPDFEKVVVRGARGLSFQIVNPEVYCVPGTKSYIVFGDAKLEDRNTASQAAALANATSQLEQKLAAMKTQDDDASKNNPTTSSSKDDAADEEDVDETGVDSANIDLVINQTGCSRAKAVKALKSNNNDVVEAILSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRC5</accession>
    <name>Q5CRC5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adenylate kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_3360</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="8" key="2">
        <citation type="submission" date="2007-11" db="PDB data bank">
            <title>Crystal structure of Cryptosporidium parvum adenylate kinase cgd5_3360.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Lew J."/>
                <person name="Kozieradzki I."/>
                <person name="Lin Y.H."/>
                <person name="Sun X."/>
                <person name="Khuu C."/>
                <person name="Zhao Y."/>
                <person name="Schapira M."/>
                <person name="Arrowsmith C.H."/>
                <person name="Edwards A.M."/>
                <person name="Weigelt J."/>
                <person name="Bochkarev A."/>
                <person name="Hui R."/>
                <person name="Artz J.D."/>
                <person name="Amani M."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 4-219</scope>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626261.1">
        <property type="nucleotide sequence ID" value="XM_626261.1"/>
    </dbReference>
    <dbReference type="PDB" id="3BE4">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.60 A"/>
        <property type="chains" value="A=4-219"/>
    </dbReference>
    <dbReference type="PDBsum" id="3BE4"/>
    <dbReference type="AlphaFoldDB" id="Q5CRC5"/>
    <dbReference type="SMR" id="Q5CRC5"/>
    <dbReference type="FunCoup" id="Q5CRC5">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRC5"/>
    <dbReference type="GeneID" id="3373218"/>
    <dbReference type="KEGG" id="cpv:cgd5_3360"/>
    <dbReference type="InParanoid" id="Q5CRC5"/>
    <dbReference type="OMA" id="VYHEQTA"/>
    <dbReference type="OrthoDB" id="439792at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CRC5"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000106">
        <property type="entry name" value="Adenylate kinase mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006259">
        <property type="entry name" value="Adenyl_kin_sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007862">
        <property type="entry name" value="Adenylate_kinase_lid-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01351">
        <property type="entry name" value="adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001380">
        <property type="entry name" value="PRK00279.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001381">
        <property type="entry name" value="PRK00279.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF011100">
        <property type="entry name" value="PRK14527.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05191">
        <property type="entry name" value="ADK_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 4 6" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Adenylate kinase active site lid" evidence="5">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="3BE4"/>
        </source>
    </evidence>
    <sequence length="221" mass="24356" checksum="4E16292DBF4485C6" modified="2005-04-12" version="1" fragment="single">KMSNSKKHNLILIGAPGSGKGTQCEFIKKEYGLAHLSTGDMLREAIKNGTKIGLEAKSIIESGNFVGDEIVLGLVKEKFDLGVCVNGFVLDGFPRTIPQAEGLAKILSEIGDSLTSVIYFEIDDSEIIERISGRCTHPASGRIYHVKYNPPKQPGIDDVTGEPLVWRDDDNAEAVKVRLDVFHKQTAPLVKFYEDLGILKRVNAKLPPKEVTEQIKKILEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRJ4</accession>
    <name>Q5CRJ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Polyubiquitin with 3 Ub domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_2550</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88214.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626192.1">
        <property type="nucleotide sequence ID" value="XM_626192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRJ4"/>
    <dbReference type="FunCoup" id="Q5CRJ4">
        <property type="interactions" value="73"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRJ4"/>
    <dbReference type="GeneID" id="3373352"/>
    <dbReference type="KEGG" id="cpv:cgd5_2550"/>
    <dbReference type="InParanoid" id="Q5CRJ4"/>
    <dbReference type="OMA" id="NTNMQIF"/>
    <dbReference type="OrthoDB" id="428577at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd01803">
        <property type="entry name" value="Ubl_ubiquitin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.20.90:FF:000158">
        <property type="entry name" value="Polyubiquitin 5"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019956">
        <property type="entry name" value="Ubiquitin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050158">
        <property type="entry name" value="Ubiquitin_ubiquitin-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10666">
        <property type="entry name" value="UBIQUITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00348">
        <property type="entry name" value="UBIQUITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0832">Ubl conjugation</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="13"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="89"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="165"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88214.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="241" mass="27261" checksum="167094887F1F1B1A" modified="2005-04-12" version="1" fragment="single">LIYYRDCSKNTNMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGMQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRP7</accession>
    <name>Q5CRP7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AtPH1 like protein with a pleckstrin homology (PH) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626139.1">
        <property type="nucleotide sequence ID" value="XM_626139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRP7"/>
    <dbReference type="STRING" id="353152.Q5CRP7"/>
    <dbReference type="GeneID" id="3373083"/>
    <dbReference type="KEGG" id="cpv:cgd5_1970"/>
    <dbReference type="InParanoid" id="Q5CRP7"/>
    <dbReference type="OMA" id="SECLTVR"/>
    <dbReference type="OrthoDB" id="185175at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd13276">
        <property type="entry name" value="PH_AtPH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000286">
        <property type="entry name" value="PH-protein kinase domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051707">
        <property type="entry name" value="PI-Interact_SigTrans_Reg"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336:SF8">
        <property type="entry name" value="PROTEIN OPY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14336">
        <property type="entry name" value="TANDEM PH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="17"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="123" mass="14771" checksum="329C169DAC56C0F6" modified="2005-04-12" version="1" fragment="single">LPHMFLGSPQISIRQDEIVKQGWLYKQSRFLKDWRRRWFVLTRNYLASFKDQRSLSTPTESLMLSECLTVRSADEDTNKENSFRVDTPNRVFFLIAENPIEKEEWIGQIGRQMIRPTVYQHDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRS7</accession>
    <name>Q5CRS7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein with signal peptide, and 11 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_1630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626109.1">
        <property type="nucleotide sequence ID" value="XM_626109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRS7"/>
    <dbReference type="STRING" id="353152.Q5CRS7"/>
    <dbReference type="GeneID" id="3373090"/>
    <dbReference type="KEGG" id="cpv:cgd5_1630"/>
    <dbReference type="InParanoid" id="Q5CRS7"/>
    <dbReference type="OMA" id="IPAWVYY"/>
    <dbReference type="OrthoDB" id="513400at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF702">
        <property type="entry name" value="AMINO ACID TRANSPORTER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="41"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="208"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="300"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="346"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="492"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="10"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="552" mass="62015" checksum="1430C0EA03397626" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRV2</accession>
    <name>Q5CRV2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_1370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626084.1">
        <property type="nucleotide sequence ID" value="XM_626084.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRV2"/>
    <dbReference type="GeneID" id="3373289"/>
    <dbReference type="KEGG" id="cpv:cgd5_1370"/>
    <dbReference type="InParanoid" id="Q5CRV2"/>
    <dbReference type="OrthoDB" id="27923at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="177" mass="20176" checksum="87EC99DAE3AA4F84" modified="2005-04-12" version="1">MALFSSNLMDLISSLPSINLEKINIFIDHLAGFFSYTKSIFNWMINQSIDFIRKHCFSNCAELYSKFVTNFKNLGCLLSSITRKFTEASKNVGSKLQTLLENISRLSKDTIEKTNLFGKELCVFGKEIFIKVKSAILAIKEGSAGKFLEVYLGQFTFFRFQLRDYPAITKVVCKLVC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS00</accession>
    <name>Q5CS00_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Membrane associated protein with a transmembrane domain near C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd5_830</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TIP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626036.1">
        <property type="nucleotide sequence ID" value="XM_626036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS00"/>
    <dbReference type="FunCoup" id="Q5CS00">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="GeneID" id="3373137"/>
    <dbReference type="KEGG" id="cpv:cgd5_830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_830"/>
    <dbReference type="InParanoid" id="Q5CS00"/>
    <dbReference type="OMA" id="PGDWIPW"/>
    <dbReference type="OrthoDB" id="10022113at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057089">
        <property type="entry name" value="C2_TIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013517">
        <property type="entry name" value="FG-GAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028994">
        <property type="entry name" value="Integrin_alpha_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024881">
        <property type="entry name" value="Tip"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412:SF0">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13412">
        <property type="entry name" value="T-CELL IMMUNOMODULATORY PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23122">
        <property type="entry name" value="C2_ITFG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13517">
        <property type="entry name" value="FG-GAP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69318">
        <property type="entry name" value="Integrin alpha N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="860"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="domain" description="T-cell immunomodulatory protein TIP C2" evidence="9">
        <location>
            <begin position="724"/>
            <end position="849"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF23122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="901" mass="102194" checksum="42C5F44D747E91EF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS10</accession>
    <name>Q5CS10_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein with 5 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd5_710</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the YIF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626026.1">
        <property type="nucleotide sequence ID" value="XM_626026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS10"/>
    <dbReference type="STRING" id="353152.Q5CS10"/>
    <dbReference type="GeneID" id="3373305"/>
    <dbReference type="KEGG" id="cpv:cgd5_710"/>
    <dbReference type="InParanoid" id="Q5CS10"/>
    <dbReference type="OMA" id="PFGARAN"/>
    <dbReference type="OrthoDB" id="341140at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005793">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005578">
        <property type="entry name" value="Yif1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083">
        <property type="entry name" value="YIP1 INTERACTING FACTOR HOMOLOG YIF1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14083:SF0">
        <property type="entry name" value="YIP1D-INTERACTING FACTOR 1, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03878">
        <property type="entry name" value="YIF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="256"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="289"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="347"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="410" mass="45369" checksum="B3E8B80886B17D14" modified="2005-04-12" version="1" fragment="single">IDCSKYNTIHMNGIRKVNNTSEHMHNYGGDKPLNNPFGARANVSGFPENNYYSNNPSMSYSQNGHLSGQQMDFYNWDSNTNNSFNVGSGAFSLNTNDADSNTFNTFNNANQQFPAFSNDNYQSYNAPEMNSNGSNGGFGGVNNGGSIPGNNMLNFGNNTSQLVMGIVSNTVKETTGLNSEKISQLQLWFPQTIASLRSHFAVSHEYVIKKILLIICPYITFFTQNKRKSFSYENHTSISSNANDGGVNLPTLFSDLYIPLMGFITYILADGVINGVFSQFNPQMLGSTATFSIVLLITEIILFQLVAYIFAARVLSTLDLISTLGYKYTSIVLCDFALLSTGGIKTYLFWALFIYFSISSSLLVYMMLKVISTRSFSNQFSMIQQSGLTIVIIISSLVQIPLCWILLPSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS53</accession>
    <name>Q5CS53_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">OB domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88188.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625983.1">
        <property type="nucleotide sequence ID" value="XM_625983.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS53"/>
    <dbReference type="GeneID" id="3373195"/>
    <dbReference type="KEGG" id="cpv:cgd5_190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_190"/>
    <dbReference type="InParanoid" id="Q5CS53"/>
    <dbReference type="OMA" id="EFKIHDF"/>
    <dbReference type="OrthoDB" id="25571at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000781">
        <property type="term" value="C:chromosome, telomeric region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005662">
        <property type="term" value="C:DNA replication factor A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040260">
        <property type="entry name" value="RFA2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989">
        <property type="entry name" value="REPLICATION PROTEIN A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13989:SF16">
        <property type="entry name" value="REPLICATION PROTEIN A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OB" evidence="5">
        <location>
            <begin position="120"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88188.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="346" mass="39618" checksum="5C8274939F4E7BF0" modified="2005-04-12" version="1">MFFSSGSFGESPFSTRNECNSSTRSSSISKSESNNTFNYFNNTNSDGIENRWNNNNNSLVTPSRRVSITTNNTTINSNNRNENMNRIQRMCLPVNISMILKSLESSPSVFKMFERRISSVTLVGWITHREILASRMIFRVSDGTGGIDARFDIDSETLGDEINSYLDNLREGTIVRLVGQVVPGKGDISTYISCYTVLKIEEMGEYAYYHSIEVAYVTNQFEQEIMENELNIKEENNTYLSPYTISTNNSNTNELMNEDFNLDLIKDINVPDDITNKTHQIVYKTLSYEIMNLKSEEKKSLGINKDHIIKILRPYYEPSTILSTISDLESKYAVIYETMDNHYCIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS64</accession>
    <name>Q5CS64_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Phosphoenolpyruvate carboxylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_70</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625972.1">
        <property type="nucleotide sequence ID" value="XM_625972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS64"/>
    <dbReference type="FunCoup" id="Q5CS64">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS64"/>
    <dbReference type="GeneID" id="3373336"/>
    <dbReference type="KEGG" id="cpv:cgd5_70"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_70"/>
    <dbReference type="InParanoid" id="Q5CS64"/>
    <dbReference type="OMA" id="VFGWTQS"/>
    <dbReference type="OrthoDB" id="1365747at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008964">
        <property type="term" value="F:phosphoenolpyruvate carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015977">
        <property type="term" value="P:carbon fixation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006099">
        <property type="term" value="P:tricarboxylic acid cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1440.90">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021135">
        <property type="entry name" value="PEP_COase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033129">
        <property type="entry name" value="PEPCASE_His_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015813">
        <property type="entry name" value="Pyrv/PenolPyrv_kinase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30523:SF6">
        <property type="entry name" value="PHOSPHOENOLPYRUVATE CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00311">
        <property type="entry name" value="PEPcase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00150">
        <property type="entry name" value="PEPCARBXLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51621">
        <property type="entry name" value="Phosphoenolpyruvate/pyruvate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00393">
        <property type="entry name" value="PEPCASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0670">Pyruvate</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" evidence="1">
        <location>
            <position position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1148" mass="130836" checksum="38A076418DF5A022" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSD1</accession>
    <name>Q5CSD1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_3200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628136.1">
        <property type="nucleotide sequence ID" value="XM_628136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSD1"/>
    <dbReference type="STRING" id="353152.Q5CSD1"/>
    <dbReference type="GeneID" id="3371462"/>
    <dbReference type="KEGG" id="cpv:cgd1_3200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3200"/>
    <dbReference type="InParanoid" id="Q5CSD1"/>
    <dbReference type="OMA" id="IWSINAL"/>
    <dbReference type="OrthoDB" id="343397at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070072">
        <property type="term" value="P:vacuolar proton-transporting V-type ATPase complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021013">
        <property type="entry name" value="ATPase_Vma12"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11712">
        <property type="entry name" value="Vma12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="166"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="219"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="219"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="254" mass="29046" checksum="DBF12D4C4E5506E9" modified="2005-04-12" version="1">MKVSVTPELKDFFSKYGDKSFKNSDNIDVDTLYKAYSKIVKEYNSINKENGTDEKNVDSIPSLQELLLNSKKEIDLDQNQKNATQKNLSIIEILRKRSEERKYQSSIKNLSQAKYTKTSNNVPDAFGVHYSRDVLMSMNALIGLILTFIGGFYAPLYMGLEDINSRIFIGIACSILCLIAEVGLFMIYDIKRNMKVSKVMKEDPVYKYLNSKERSKTTNIYKPITNNNKTNNNKQTSKNKNSAKSKKGKKHKTD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSD5</accession>
    <name>Q5CSD5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">mRNA 3' end processing protein RNA14, HAT repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_3160</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628132.1">
        <property type="nucleotide sequence ID" value="XM_628132.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSD5"/>
    <dbReference type="GeneID" id="3371466"/>
    <dbReference type="KEGG" id="cpv:cgd1_3160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3160"/>
    <dbReference type="InParanoid" id="Q5CSD5"/>
    <dbReference type="OMA" id="NEIKWIC"/>
    <dbReference type="OrthoDB" id="3366823at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045243">
        <property type="entry name" value="Rna14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008847">
        <property type="entry name" value="Suf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980:SF0">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19980">
        <property type="entry name" value="RNA CLEAVAGE STIMULATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05843">
        <property type="entry name" value="Suf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Suppressor of forked" evidence="5">
        <location>
            <begin position="11"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="domain" description="Suppressor of forked" evidence="5">
        <location>
            <begin position="241"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="413"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="806"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1303"/>
            <end position="1365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1433"/>
            <end position="1452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="421"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="476"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1303"/>
            <end position="1340"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1350"/>
            <end position="1365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1452" mass="165177" checksum="7D1D9DA5055931D8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSE3</accession>
    <name>Q5CSE3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Splicing factor U2AF like SnRNP auxilary factor large subunit, RRM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_3080</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628124.1">
        <property type="nucleotide sequence ID" value="XM_628124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSE3"/>
    <dbReference type="STRING" id="353152.Q5CSE3"/>
    <dbReference type="GeneID" id="3371342"/>
    <dbReference type="KEGG" id="cpv:cgd1_3080"/>
    <dbReference type="InParanoid" id="Q5CSE3"/>
    <dbReference type="OMA" id="FYDGFQW"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="56"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="330" mass="37100" checksum="BFCA81C7639DFADB" modified="2005-04-12" version="1" fragment="single">TFLFRCIKKAGGFQKLAQSEGKEPTPVFYDGFQWVAKTGSTASMDPATMNNTRRFRRLYFGNLPINLGLTESSFQQIVWQEMALRGLCLNPNENPILCVWFAQKKGNYGFVEFRTVEETEKALQLDGFACMGSKIKVSRPNDYSQALQSSSSSTAVGGSGTNIQSPYNSVLNPINNLNSHTTINGAITKDNAFYLGQETALQLLFTLEDTYSLGTRNLDSKVLRITNVLDPCQIQDPEECREIKRDFCDGIQYKDSIISSRIITIDDISRLCQELAEKDIQLEPADILLEFDSNTNLQLSVSAMSIANYNNKIPKMNLFDEDFYHNHLKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSE9</accession>
    <name>Q5CSE9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 8">Fructose-bisphosphate aldolase</fullName>
            <ecNumber evidence="4 8">4.1.2.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_3020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 8">
            <text>beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate</text>
            <dbReference type="Rhea" id="RHEA:14729"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.1.2.13"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 9">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 4/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the class I fructose-bisphosphate aldolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.13" evidence="4 8"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628118.1">
        <property type="nucleotide sequence ID" value="XM_628118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSE9"/>
    <dbReference type="SMR" id="Q5CSE9"/>
    <dbReference type="FunCoup" id="Q5CSE9">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSE9"/>
    <dbReference type="GeneID" id="3371343"/>
    <dbReference type="KEGG" id="cpv:cgd1_3020"/>
    <dbReference type="InParanoid" id="Q5CSE9"/>
    <dbReference type="OMA" id="WRAVITI"/>
    <dbReference type="OrthoDB" id="36455at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00183"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004332">
        <property type="term" value="F:fructose-bisphosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00948">
        <property type="entry name" value="FBP_aldolase_I_a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.70:FF:000140">
        <property type="entry name" value="Fructose-bisphosphate aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029768">
        <property type="entry name" value="Aldolase_I_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000741">
        <property type="entry name" value="FBA_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF033379">
        <property type="entry name" value="FrucBisAld_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11627">
        <property type="entry name" value="FRUCTOSE-BISPHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00274">
        <property type="entry name" value="Glycolytic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00158">
        <property type="entry name" value="ALDOLASE_CLASS_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 8 10" id="KW-0456">Lyase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0704">Schiff base</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004714"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="369" mass="39968" checksum="72B3EEA57F3EED12" modified="2005-04-12" version="1" fragment="single">KISFYLFQKKKMSICQERAKELAENARKIASPGKGILAADESTGTIKKRFDQVGIENTEANRAAYRELLFKTEGLNQYISGVILYEETLFQSTASGEKMTDLLKKQGILPGIKVDMGLTTLPLTDGETSTTGLDGLGARCKKYYDAGARFAKWRAVLTIDQAKGKPSCLSISETAHTLARYAAICQENGLVPIVEPEILSDGSHDIEFCAKVTEKVLAEVVKALHLHRVLLEGSLLKPNMVTPGSDCPKRASSQEVAFYTVRTLKRTIPSAMAGVMFLSGGQSEEEASLNLCEMNKIKDCPLFLSFSYGRALQASVLKAWKGDASNVPAAQKALLERAKANSEAQLGVYKGGVGGSAASEGLFVKSYVY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSJ9</accession>
    <name>Q5CSJ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical secreted/membrane associated protein signal peptide plus possible GPI signal</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_2390</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628068.1">
        <property type="nucleotide sequence ID" value="XM_628068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSJ9"/>
    <dbReference type="GeneID" id="3371667"/>
    <dbReference type="KEGG" id="cpv:cgd1_2390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2390"/>
    <dbReference type="InParanoid" id="Q5CSJ9"/>
    <dbReference type="OMA" id="VINPCHY"/>
    <dbReference type="OrthoDB" id="339062at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253798" evidence="2">
        <location>
            <begin position="23"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="219" mass="24035" checksum="3E684DDFE8319876" modified="2005-04-12" version="1">MKTITVAIVLSLVWIYVHFCSSFENRIEDIALLKLRGSVEMGDQLKGGPHYTGMMVGGRHVGIEHSLDLGDLSQVYRCLFYSTHPGSCNPSGTVINPCHFCRTEVVYAVASAKCPGDESFPPSLAPLYMWVLKPYHIRKRLGHQYLCAVEPNPAAKYASRPSNESPLSSDENSYPLPPEIPFSPSNNQNESLSESTLMIIIGSGVLLTLLLCGVGLYMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSK2</accession>
    <name>Q5CSK2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_2350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628065.1">
        <property type="nucleotide sequence ID" value="XM_628065.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSK2"/>
    <dbReference type="GeneID" id="3371669"/>
    <dbReference type="KEGG" id="cpv:cgd1_2350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2350"/>
    <dbReference type="InParanoid" id="Q5CSK2"/>
    <dbReference type="OMA" id="NARAKIC"/>
    <dbReference type="OrthoDB" id="338281at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="559" mass="63959" checksum="8ED1F52B54248B1F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSP3</accession>
    <name>Q5CSP3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G-patch domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_1850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628024.1">
        <property type="nucleotide sequence ID" value="XM_628024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSP3"/>
    <dbReference type="GeneID" id="3371663"/>
    <dbReference type="KEGG" id="cpv:cgd1_1850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1850"/>
    <dbReference type="InParanoid" id="Q5CSP3"/>
    <dbReference type="OMA" id="NNDCKIP"/>
    <dbReference type="OrthoDB" id="77405at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="107"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="149" mass="16913" checksum="DE9ED290BA25CEE9" modified="2005-04-12" version="1">MDDLYFGLPPPVSKRSNPDTETSSSSGIDEISAIKKSNTWNIFIDSSINHNIVCEMEGQDIRCGNKSGNLLDLEYDPKSPNTYTIHQNKSESPPAENKISVEKTEIKFEIGQKLLEKMGWKQGEGLGKNNQGIKFPIKIYRKKDFIKRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSS9</accession>
    <name>Q5CSS9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627988.1">
        <property type="nucleotide sequence ID" value="XM_627988.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSS9"/>
    <dbReference type="GeneID" id="3371617"/>
    <dbReference type="KEGG" id="cpv:cgd1_1470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1470"/>
    <dbReference type="InParanoid" id="Q5CSS9"/>
    <dbReference type="OMA" id="YEIATYE"/>
    <dbReference type="OrthoDB" id="332663at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="665" mass="76833" checksum="5A2D75DABEF3F747" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT00</accession>
    <name>Q5CT00_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted secreted protein, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
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        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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            <begin position="1"/>
            <end position="25"/>
        </location>
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            <end position="1273"/>
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            <begin position="345"/>
            <end position="381"/>
        </location>
    </feature>
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            <end position="757"/>
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            <end position="973"/>
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            <end position="659"/>
        </location>
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            <end position="678"/>
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        </source>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAK88502.1"/>
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    </evidence>
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        <source>
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        </source>
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    <sequence length="1273" mass="145821" checksum="22C7896DF38C705E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT04</accession>
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        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
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                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_590"/>
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    <dbReference type="OMA" id="LENACEN"/>
    <dbReference type="OrthoDB" id="344127at2759"/>
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    </dbReference>
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            <end position="22"/>
        </location>
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            <end position="950"/>
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            <end position="1026"/>
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    </evidence>
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    </evidence>
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        <source>
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        </source>
    </evidence>
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        <source>
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        </source>
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</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT45</accession>
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        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
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    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
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                <person name="Abrahamsen M.S."/>
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                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="nucleotide sequence ID" value="XM_627872.1"/>
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    <dbReference type="GeneID" id="3371433"/>
    <dbReference type="KEGG" id="cpv:cgd1_100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_100"/>
    <dbReference type="InParanoid" id="Q5CT45"/>
    <dbReference type="OMA" id="TWIINIT"/>
    <dbReference type="OrthoDB" id="342592at2759"/>
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    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1038" mass="121290" checksum="70C0235A976B876D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT60</accession>
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        <submittedName>
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    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
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                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
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            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
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        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
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    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="STRING" id="353152.Q5CT60"/>
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    <dbReference type="KEGG" id="cpv:cgd2_4300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4300"/>
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    <dbReference type="OMA" id="DYQKEDN"/>
    <dbReference type="OrthoDB" id="10267058at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
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    <dbReference type="GO" id="GO:0047429">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00985">
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        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="HAMAP" id="MF_00528">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029001">
        <property type="entry name" value="ITPase-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003697">
        <property type="entry name" value="Maf-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213:SF4">
        <property type="entry name" value="7-METHYL-GTP PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43213">
        <property type="entry name" value="BIFUNCTIONAL DTTP/UTP PYROPHOSPHATASE/METHYLTRANSFERASE PROTEIN-RELATED"/>
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    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006305">
        <property type="entry name" value="Maf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52972">
        <property type="entry name" value="ITPase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="211" mass="23712" checksum="843946A5F2A408F2" modified="2005-04-12" version="1">MYENHNFKKDYKIVFGSTSESRRMVFSKANIKLSEFVSADIDERAITDDDPNKLVIKLSEAKMDAVLEKLPYKNGEDKVIVICADTIALKDGEVRNKAKDSDERLRYVKSYSESYADCITGVTVYNYFTGRRLSNVTVSRVHYKKMPDEAIQQIVENSEIIKYSCGALAIDCPFMGKFVDGIQGDVDNIMGISVCNTVELMEKSIALGVVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT75</accession>
    <name>Q5CT75_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Articulin family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_4150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626594.1">
        <property type="nucleotide sequence ID" value="XM_626594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT75"/>
    <dbReference type="GeneID" id="3373487"/>
    <dbReference type="KEGG" id="cpv:cgd2_4150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4150"/>
    <dbReference type="InParanoid" id="Q5CT75"/>
    <dbReference type="OMA" id="EPDIHTM"/>
    <dbReference type="OrthoDB" id="375509at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022086">
        <property type="entry name" value="IMCp"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12314">
        <property type="entry name" value="IMCp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="11"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="392" mass="43707" checksum="F537D4DFF077BD6A" modified="2005-04-12" version="1">MAEVPVSEDISASQQPPSSSYSLPPQFSNEPDVRTMASIKATLSKKAEELVKAGQPYVMTSLGPIPLPDNVRNQIPEKFVAAPVLEEREVIVARREVQERIIEVPQIQYEHKFVEVPQKVVVEKIIPIPKDVVREVEIPRYTATVEEKVIEVPQGVKFVEVPVEVPIAYPPRIVPVPKPYIVERTVELSRPVIEERLLEVPQKVYRQVPYYKDVEVPFVVPRYVEKLVEIPFHPGMMYDENMLNQSIPPIPPQSQPPFMMGGPGSAPTSAPLLSMPPPMYGTNDPEDVASDGLPSHPAIPPYHMLPQPQPGVIPQMIPLANSYAAFPLPQGVGMSPHMLNSGNTAHIPGKTPVPFNPPQQPPQNLLNGVNINQIQFPPNQRQQFPYQFPPQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTE3</accession>
    <name>Q5CTE3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_3360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88686.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626526.1">
        <property type="nucleotide sequence ID" value="XM_626526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTE3"/>
    <dbReference type="SMR" id="Q5CTE3"/>
    <dbReference type="GeneID" id="3373764"/>
    <dbReference type="KEGG" id="cpv:cgd2_3360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3360"/>
    <dbReference type="InParanoid" id="Q5CTE3"/>
    <dbReference type="OMA" id="HRIKYIN"/>
    <dbReference type="OrthoDB" id="342998at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254503" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1007"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="768"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="937"/>
            <end position="1002"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88686.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1007" mass="117119" checksum="84EBEC3396CDA628" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTU8</accession>
    <name>Q5CTU8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">THH1/TOM1/TOM3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_1490</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the plant tobamovirus multiplication TOM1 protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88822.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626371.1">
        <property type="nucleotide sequence ID" value="XM_626371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTU8"/>
    <dbReference type="GeneID" id="3373724"/>
    <dbReference type="KEGG" id="cpv:cgd2_1490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1490"/>
    <dbReference type="InParanoid" id="Q5CTU8"/>
    <dbReference type="OMA" id="LFWSQVY"/>
    <dbReference type="OrthoDB" id="19798at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040226">
        <property type="entry name" value="THH1/TOM1/TOM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009457">
        <property type="entry name" value="THH1/TOM1/TOM3_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142:SF3">
        <property type="entry name" value="THH1_TOM1_TOM3 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31142">
        <property type="entry name" value="TOBAMOVIRUS MULTIPLICATION PROTEIN 1-LIKE ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06454">
        <property type="entry name" value="THH1_TOM1-3_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="45"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="101"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="132"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="160"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="THH1/TOM1/TOM3" evidence="7">
        <location>
            <begin position="83"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88822.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="333" mass="38020" checksum="DA50FA01AFCE2806" modified="2005-04-12" version="1">MILFYTIDLILFITLDVVILQQALKMKSTYYSEMRFTSMSSISHRTRVCFILLCLLANITRTISIIILDLTWPIVSEYRLLLKNETNIEEWSLDLLRTLPSLVYLSSYSVVVLFWAHVYYTSILISTPQMVSFFVAINTIIYGLYIIGMVVSLFSNILSFASISMFLLAISYISISISMLYYGIKVVSHLTRRAASGTILRYNVIQRVLFLTIFCPVLLFIRGIISGVQCIYSIIGFPTYFKIFDKTPIGDSVIFILTELFPSIVIVVSFWQKISPSTLTVSTRGLGFTSGVFSNIQNTNDNYNTHHSFHLIQNINALNNIDELVKKKDREIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU47</accession>
    <name>Q5CU47_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Insulinase like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd3_4240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626967.1">
        <property type="nucleotide sequence ID" value="XM_626967.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU47"/>
    <dbReference type="SMR" id="Q5CU47"/>
    <dbReference type="STRING" id="353152.Q5CU47"/>
    <dbReference type="GeneID" id="3374006"/>
    <dbReference type="KEGG" id="cpv:cgd3_4240"/>
    <dbReference type="InParanoid" id="Q5CU47"/>
    <dbReference type="OMA" id="FRRICIF"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="7">
        <location>
            <begin position="44"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="8">
        <location>
            <begin position="207"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1113" mass="130236" checksum="4A3726C8CA7EACDB" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU53</accession>
    <name>Q5CU53_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Secreted insulinase like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_4180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626961.1">
        <property type="nucleotide sequence ID" value="XM_626961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU53"/>
    <dbReference type="SMR" id="Q5CU53"/>
    <dbReference type="STRING" id="353152.Q5CU53"/>
    <dbReference type="GeneID" id="3374007"/>
    <dbReference type="KEGG" id="cpv:cgd3_4180"/>
    <dbReference type="InParanoid" id="Q5CU53"/>
    <dbReference type="OMA" id="CINYSAG"/>
    <dbReference type="OrthoDB" id="4953at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="95"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="256"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="538"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="577"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="597"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1215" mass="138917" checksum="B55FAE2FDE1179CF" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU65</accession>
    <name>Q5CU65_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_4050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the cyclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626949.1">
        <property type="nucleotide sequence ID" value="XM_626949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU65"/>
    <dbReference type="STRING" id="353152.Q5CU65"/>
    <dbReference type="GeneID" id="3374008"/>
    <dbReference type="KEGG" id="cpv:cgd3_4050"/>
    <dbReference type="InParanoid" id="Q5CU65"/>
    <dbReference type="OMA" id="MINMEVE"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.472.10:FF:000001">
        <property type="entry name" value="G2/mitotic-specific cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013763">
        <property type="entry name" value="Cyclin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048258">
        <property type="entry name" value="Cyclins_cyclin-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00385">
        <property type="entry name" value="CYCLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00292">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="1" id="KW-0132">Cell division</keyword>
    <keyword evidence="2 4" id="KW-0195">Cyclin</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin-like" evidence="5">
        <location>
            <begin position="83"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00385"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="344" mass="40318" checksum="0B1A120D988D6FC9" modified="2005-04-12" version="1" fragment="single">NKKKSLLFTMVKRSAKEVTSNYNESYENGIYYKQLNKQDTRNSDFVNEFEIKNVTTLQEEKNNYNKKLIENGLNNICRVIVLDWLIGVHRKFQFRPATIHIGITLFDRFIRLNNKHGLINCDNLQLVGATCLHIASKYEDMNPAVLLDYCIMSNSEFNPKDMINMEVEILNTLHFKIADNTTLIDYLDSFFEYGILKGVNKKKLPKYFYSSALYISELSLLHQAMIFYRPKVLSTSILLLLCLLFEKDESERNNLSILKDLKYSLKRFSKINNITKEIRICIKSLLGIIKEQFFLEVKIKEGFENSIIGVNPEEEIPFIYLKDLTSKWRNAYTNLYKKISSLRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU79</accession>
    <name>Q5CU79_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L30, pelota RNA binding domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_3890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="5">Iowa type II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL30 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626935.1">
        <property type="nucleotide sequence ID" value="XM_626935.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU79"/>
    <dbReference type="FunCoup" id="Q5CU79">
        <property type="interactions" value="364"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU79"/>
    <dbReference type="GeneID" id="3373925"/>
    <dbReference type="KEGG" id="cpv:cgd3_3890"/>
    <dbReference type="InParanoid" id="Q5CU79"/>
    <dbReference type="OMA" id="YFQGGNN"/>
    <dbReference type="OrthoDB" id="1928736at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000001">
        <property type="entry name" value="60S ribosomal protein L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039109">
        <property type="entry name" value="Ribosomal_eL30-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022991">
        <property type="entry name" value="Ribosomal_eL30_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002172">
        <property type="entry name" value="PRK01018.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11449">
        <property type="entry name" value="RIBOSOMAL PROTEIN L30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00993">
        <property type="entry name" value="RIBOSOMAL_L30E_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="4">
        <location>
            <begin position="17"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="111" mass="12178" checksum="4FF9FF541FB8B21C" modified="2005-04-12" version="1" fragment="single">IKMAKKGSSKGKSEGMTSRLQLVMKSGKVCLGYRSTVKSIRNGTARLVIISNNCPPLRRSEIEYYAMLSKIGVHHFQGGNNDLGTSCGKLYRVSCMTVTDPGDSDIIRSYE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU93</accession>
    <name>Q5CU93_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_3730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626921.1">
        <property type="nucleotide sequence ID" value="XM_626921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU93"/>
    <dbReference type="GeneID" id="3373855"/>
    <dbReference type="KEGG" id="cpv:cgd3_3730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3730"/>
    <dbReference type="InParanoid" id="Q5CU93"/>
    <dbReference type="OMA" id="TCTHRDL"/>
    <dbReference type="OrthoDB" id="343601at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022773">
        <property type="entry name" value="Siva"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05458">
        <property type="entry name" value="Siva"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="122" mass="14309" checksum="92D929AA507CA1E1" modified="2005-04-12" version="1">MKRERNYDYENETNFNTIKKSERVIDKDNKQKHTVWCLTQSQKNLNQIIKEYCSLCNRRSLNKSNLNIEKVKCGYCDRSTCDNANCKLSECSNCELVICNLCGNYNYGNNTYNNSIYCPNCI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUC5</accession>
    <name>Q5CUC5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd3_3380</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89255.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626889.1">
        <property type="nucleotide sequence ID" value="XM_626889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUC5"/>
    <dbReference type="FunCoup" id="Q5CUC5">
        <property type="interactions" value="22"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUC5"/>
    <dbReference type="GeneID" id="3373940"/>
    <dbReference type="KEGG" id="cpv:cgd3_3380"/>
    <dbReference type="InParanoid" id="Q5CUC5"/>
    <dbReference type="OMA" id="NASEQCV"/>
    <dbReference type="OrthoDB" id="1191041at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF21">
        <property type="entry name" value="DEAD-BOX HELICASE 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="48"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="278"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038041"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89255.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="664" mass="75549" checksum="8CC40F1D495DB2E6" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUJ1</accession>
    <name>Q5CUJ1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Diacylglycerol kinase</fullName>
            <shortName evidence="12">DAG kinase</shortName>
            <ecNumber evidence="12">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd3_2630</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>a 1,2-diacyl-sn-glycerol + ATP = a 1,2-diacyl-sn-glycero-3-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10272"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58608"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.107"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="12"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626823.1">
        <property type="nucleotide sequence ID" value="XM_626823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUJ1"/>
    <dbReference type="FunCoup" id="Q5CUJ1">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUJ1"/>
    <dbReference type="GeneID" id="3373969"/>
    <dbReference type="KEGG" id="cpv:cgd3_2630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2630"/>
    <dbReference type="InParanoid" id="Q5CUJ1"/>
    <dbReference type="OMA" id="CIADEIN"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20805">
        <property type="entry name" value="C1_DGK_rpt2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002219">
        <property type="entry name" value="PKC_DAG/PE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF54">
        <property type="entry name" value="DIACYLGLYCEROL KINASE THETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00109">
        <property type="entry name" value="C1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00045">
        <property type="entry name" value="DAGKa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00046">
        <property type="entry name" value="DAGKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50081">
        <property type="entry name" value="ZF_DAG_PE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 12 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="9" id="KW-0862">Zinc</keyword>
    <keyword evidence="7" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="87"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="Phorbol-ester/DAG-type" evidence="14">
        <location>
            <begin position="187"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="DAGKc" evidence="15">
        <location>
            <begin position="347"/>
            <end position="487"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK89058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="919" mass="105006" checksum="F08990C0C1852CC1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUP4</accession>
    <name>Q5CUP4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_2000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat cdt2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626770.1">
        <property type="nucleotide sequence ID" value="XM_626770.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUP4"/>
    <dbReference type="GeneID" id="3374047"/>
    <dbReference type="KEGG" id="cpv:cgd3_2000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2000"/>
    <dbReference type="InParanoid" id="Q5CUP4"/>
    <dbReference type="OMA" id="KINTNHE"/>
    <dbReference type="OrthoDB" id="2096344at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051865">
        <property type="entry name" value="WD-repeat_CDT2_adapter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852:SF0">
        <property type="entry name" value="DENTICLELESS PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22852">
        <property type="entry name" value="LETHAL 2 DENTICLELESS PROTEIN RETINOIC ACID-REGULATED NUCLEAR MATRIX-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="124"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="536"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="730"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="545"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="559"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="734"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="793" mass="87995" checksum="DB03AE2D301BF73A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUR4</accession>
    <name>Q5CUR4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89115.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626750.1">
        <property type="nucleotide sequence ID" value="XM_626750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUR4"/>
    <dbReference type="GeneID" id="3374158"/>
    <dbReference type="KEGG" id="cpv:cgd3_1780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1780"/>
    <dbReference type="InParanoid" id="Q5CUR4"/>
    <dbReference type="OrthoDB" id="343914at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254972" evidence="2">
        <location>
            <begin position="18"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="55"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="160"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89115.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="551" mass="64099" checksum="B69F1F473AC161EC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUX1</accession>
    <name>Q5CUX1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_1150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89163.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626693.1">
        <property type="nucleotide sequence ID" value="XM_626693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUX1"/>
    <dbReference type="GeneID" id="3374167"/>
    <dbReference type="KEGG" id="cpv:cgd3_1150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1150"/>
    <dbReference type="InParanoid" id="Q5CUX1"/>
    <dbReference type="OrthoDB" id="10457442at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="146"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89163.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="323" mass="37903" checksum="11461AC757C26F0B" modified="2005-04-12" version="1">MNLSFIYVMGFFPVKFFPILFFSITINNGLFSRNYEESLIDFSLSQLSAESESNDGSSRSLRSFLSLESFESCFSEFQSQSSYYTALDYGSDDSTDKVPCEFECKYSKEEILKSIRKGNYKKLKKIRTIFLEELMDEIITKVMNIILNYERQMSRKENLLAQYEVHKQLNKNKIKKIKKEIKLLKLETDCYLTRLDLYLYNLFKHLFSIKIKNFKSTTKVLKSSLHYNKINSLQREIAFNYELLSFLEAAFLHYLCNNGLFANRHLCAFILKQSLKITKFNEKIISLHKKAIDKIGVFTRPDSGSESRLETIPEEPSNSYEPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV40</accession>
    <name>Q5CV40_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="9">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd3_390</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="9"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626624.1">
        <property type="nucleotide sequence ID" value="XM_626624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV40"/>
    <dbReference type="SMR" id="Q5CV40"/>
    <dbReference type="FunCoup" id="Q5CV40">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV40"/>
    <dbReference type="GeneID" id="3373997"/>
    <dbReference type="KEGG" id="cpv:cgd3_390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_390"/>
    <dbReference type="InParanoid" id="Q5CV40"/>
    <dbReference type="OMA" id="VEYSECH"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF105">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE Q1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4 14" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="12">
        <location>
            <begin position="120"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="13">
        <location>
            <begin position="356"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="537"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="43"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="559"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK89223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="762" mass="87788" checksum="10CEF0C931071B36" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV90</accession>
    <name>Q5CV90_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Apicomplexan-conserved protein Pf 23619083 and Py 23490592 low complexity 1667 aa</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_4970</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627379.1">
        <property type="nucleotide sequence ID" value="XM_627379.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3374201"/>
    <dbReference type="KEGG" id="cpv:cgd8_4970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4970"/>
    <dbReference type="InParanoid" id="Q5CV90"/>
    <dbReference type="OMA" id="YLHFEHG"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025697">
        <property type="entry name" value="CLU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264:SF3">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51823">
        <property type="entry name" value="CLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Clu" evidence="2">
        <location>
            <begin position="120"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1667" mass="193308" checksum="ABBFC991F3141D19" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV97</accession>
    <name>Q5CV97_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative clathrin assembly protein AP19, small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_4890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627372.1">
        <property type="nucleotide sequence ID" value="XM_627372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV97"/>
    <dbReference type="GeneID" id="3374426"/>
    <dbReference type="KEGG" id="cpv:cgd8_4890"/>
    <dbReference type="InParanoid" id="Q5CV97"/>
    <dbReference type="OMA" id="NNEMGHI"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="113" mass="13397" checksum="80C2867017E13F82" modified="2005-04-12" version="1">MHEILDTSNRFSGVKRNSPLYLDSDLNIEGKMIFHRFHKRKWKMYIDSSKTKIFRMRRTQTGGVIPTNIQLGANQKIRIEAIDCLDCRIDHSDTIERRDHGVTSLIKKDEFRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVP5</accession>
    <name>Q5CVP5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted bacterial type DHHB/UbiG like methyltransferase involved in ubiquinone/menaquinone biosynthesis, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627224.1">
        <property type="nucleotide sequence ID" value="XM_627224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVP5"/>
    <dbReference type="STRING" id="353152.Q5CVP5"/>
    <dbReference type="GeneID" id="3374250"/>
    <dbReference type="KEGG" id="cpv:cgd8_3290"/>
    <dbReference type="InParanoid" id="Q5CVP5"/>
    <dbReference type="OMA" id="IESAHCY"/>
    <dbReference type="OrthoDB" id="506498at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050447">
        <property type="entry name" value="Erg6_SMT_methyltransf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068:SF11">
        <property type="entry name" value="GERANYL DIPHOSPHATE 2-C-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44068">
        <property type="entry name" value="ZGC:194242"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="2" id="KW-0830">Ubiquinone</keyword>
    <feature type="domain" description="Methyltransferase" evidence="1">
        <location>
            <begin position="116"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="262" mass="29768" checksum="19A1DAE3FA67C62B" modified="2005-04-12" version="1">MKILTVIDSILTFVWLTYWHLKSLLNIAPSFWRFCYNACNSLFTKLQYTSNIDVSFMNYGYAIKTPHSPPENSELDKFIESKLEKLKKESPPNFNDVWNSVQLYTAVLSTYDDDFKGKSILEVGCGRGGGSVVVCSVAEPMSYAGIDISDQGIELCRQIYRNDLIPAGNKVFYVGSSMELENYFAPESFDIVLNVESAHCYPNFDKFVKGVFDLLKPGGMMLFADISPTIAWPDIKVSLQNIKESSFNTRLGYNCKYWIPNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVQ8</accession>
    <name>Q5CVQ8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cytosolic Fe-S cluster assembly factor NUBP1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_3140</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="8">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
        <text evidence="8">Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Heterotetramer of 2 NUBP1 and 2 NUBP2 chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627211.1">
        <property type="nucleotide sequence ID" value="XM_627211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVQ8"/>
    <dbReference type="FunCoup" id="Q5CVQ8">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVQ8"/>
    <dbReference type="GeneID" id="3374239"/>
    <dbReference type="KEGG" id="cpv:cgd8_3140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3140"/>
    <dbReference type="InParanoid" id="Q5CVQ8"/>
    <dbReference type="OMA" id="DEHITIC"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03038">
        <property type="entry name" value="NUBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028601">
        <property type="entry name" value="NUBP1/Nbp35"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264:SF19">
        <property type="entry name" value="CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR NUBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23264">
        <property type="entry name" value="NUCLEOTIDE-BINDING PROTEIN NBP35 YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 8" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 8" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 8" id="KW-0408">Iron</keyword>
    <keyword evidence="7 8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="8">
        <location>
            <position position="66"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="80"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="83"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="117"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="355" mass="38804" checksum="17F6346E37D61D28" modified="2005-04-12" version="1">MKIASNRIAIFFGGLISGIIFKDYFKTFSRLTINYLKSIIFSISYIKTDSVNSKYQNHFNIQIGNCVGVDSPDAGIADSCAGCPNALICASGQAKKKPTENIENLSKIKNIILVLSGKGGVGKSTISSQISWCLSSKKFNVGLLDIDICGPSAPKMMGVQGNDVHISANGWSPVYVNDNLSVMSTAFLLPQSDDAVIWRGPKKNGLIKQFLSDVVWGELDFLIIDTPPGTSDEHLSIVSYLNGSNVNGALIVTTPQEIALQDVRKEINFCKKVGLNILGVVENMGMIFKNAEHDSSVKDMCDNMEVEYLNKIPWDKELLYVCDLGLSICEKFPQSPSSIGIKKLVDIIIYQSKIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVS3</accession>
    <name>Q5CVS3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">NIC+MI domains containing protein. nucampholin/yeast Cwc22p like protein involved in mRNA splicing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_2960</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CWC22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627196.1">
        <property type="nucleotide sequence ID" value="XM_627196.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVS3"/>
    <dbReference type="FunCoup" id="Q5CVS3">
        <property type="interactions" value="475"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVS3"/>
    <dbReference type="GeneID" id="3374328"/>
    <dbReference type="KEGG" id="cpv:cgd8_2960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2960"/>
    <dbReference type="InParanoid" id="Q5CVS3"/>
    <dbReference type="OMA" id="VIEGCCE"/>
    <dbReference type="OrthoDB" id="1924287at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050781">
        <property type="entry name" value="CWC22_splicing_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003891">
        <property type="entry name" value="Initiation_fac_eIF4g_MI"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18034:SF3">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR CWC22 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02847">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00544">
        <property type="entry name" value="MA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51366">
        <property type="entry name" value="MI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MI" evidence="6">
        <location>
            <begin position="326"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="619" mass="72141" checksum="7C565B306C2D482B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVU8</accession>
    <name>Q5CVU8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">NADPH:ferredoxin--NADP+ reductase with a rossman fold nucleotide binding domain and a 2Fe-2S ferredoxin domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_2710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627171.1">
        <property type="nucleotide sequence ID" value="XM_627171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVU8"/>
    <dbReference type="FunCoup" id="Q5CVU8">
        <property type="interactions" value="108"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVU8"/>
    <dbReference type="GeneID" id="3374396"/>
    <dbReference type="KEGG" id="cpv:cgd8_2710"/>
    <dbReference type="InParanoid" id="Q5CVU8"/>
    <dbReference type="OMA" id="AYVITQA"/>
    <dbReference type="OrthoDB" id="333024at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055275">
        <property type="entry name" value="Ferredox_Rdtase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48467:SF1">
        <property type="entry name" value="GLUTAMATE SYNTHASE 1 [NADH], CHLOROPLASTIC-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00419">
        <property type="entry name" value="ADXRDTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51971">
        <property type="entry name" value="Nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="2" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="4" id="KW-0521">NADP</keyword>
    <keyword evidence="5" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="571" mass="66485" checksum="8F8894621A0E2398" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVV2</accession>
    <name>Q5CVV2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Secreted glucose methanol choline like oxidoreductase of the FAD dependent oxidoreductase like fold, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_2670</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the GMC oxidoreductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627167.1">
        <property type="nucleotide sequence ID" value="XM_627167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVV2"/>
    <dbReference type="STRING" id="353152.Q5CVV2"/>
    <dbReference type="GeneID" id="3374383"/>
    <dbReference type="KEGG" id="cpv:cgd8_2670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2670"/>
    <dbReference type="InParanoid" id="Q5CVV2"/>
    <dbReference type="OMA" id="LYWDGQC"/>
    <dbReference type="OrthoDB" id="409726at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044550">
        <property type="term" value="P:secondary metabolite biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.410.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.560.10">
        <property type="entry name" value="Glucose Oxidase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012132">
        <property type="entry name" value="GMC_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552:SF138">
        <property type="entry name" value="DEHYDROGENASE PKFF-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11552">
        <property type="entry name" value="GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000137">
        <property type="entry name" value="Alcohol_oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54373">
        <property type="entry name" value="FAD-linked reductases, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0274">FAD</keyword>
    <keyword evidence="3" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="2" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="4">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254476" evidence="4">
        <location>
            <begin position="25"/>
            <end position="698"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="5">
        <location>
            <begin position="307"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <begin position="642"/>
            <end position="643"/>
        </location>
        <ligand>
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000137-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="698" mass="76893" checksum="4840D2160CEBBDD0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVW8</accession>
    <name>Q5CVW8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_2500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627151.1">
        <property type="nucleotide sequence ID" value="XM_627151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVW8"/>
    <dbReference type="GeneID" id="3374276"/>
    <dbReference type="KEGG" id="cpv:cgd8_2500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2500"/>
    <dbReference type="InParanoid" id="Q5CVW8"/>
    <dbReference type="OMA" id="WEGNTIM"/>
    <dbReference type="OrthoDB" id="340320at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254564" evidence="2">
        <location>
            <begin position="25"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="451"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="516" mass="59429" checksum="9AB71AEB491633D8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVZ0</accession>
    <name>Q5CVZ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Phosphatidylinositol glycan class O, integral membrane protein with signal peptide sequence and 12 or more transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_2260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627129.1">
        <property type="nucleotide sequence ID" value="XM_627129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVZ0"/>
    <dbReference type="STRING" id="353152.Q5CVZ0"/>
    <dbReference type="GeneID" id="3374390"/>
    <dbReference type="KEGG" id="cpv:cgd8_2260"/>
    <dbReference type="InParanoid" id="Q5CVZ0"/>
    <dbReference type="OMA" id="MIIPEIF"/>
    <dbReference type="OrthoDB" id="272139at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051377">
        <property type="term" value="F:mannose-ethanolamine phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd16023">
        <property type="entry name" value="GPI_EPT_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.720.10">
        <property type="entry name" value="Alkaline Phosphatase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017850">
        <property type="entry name" value="Alkaline_phosphatase_core_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037675">
        <property type="entry name" value="PIG-O_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039524">
        <property type="entry name" value="PIGO/GPI13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071:SF1">
        <property type="entry name" value="GPI ETHANOLAMINE PHOSPHATE TRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23071">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53649">
        <property type="entry name" value="Alkaline phosphatase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="530"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="601"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="633"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="679"/>
            <end position="702"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="708"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="770"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="795"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="817"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="929"/>
            <end position="947"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="967"/>
            <end position="992"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1004"/>
            <end position="1024"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1030"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1054" mass="124090" checksum="EEFA77B842BCC471" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW34</accession>
    <name>Q5CW34_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627085.1">
        <property type="nucleotide sequence ID" value="XM_627085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW34"/>
    <dbReference type="GeneID" id="3374503"/>
    <dbReference type="KEGG" id="cpv:cgd8_1790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1790"/>
    <dbReference type="InParanoid" id="Q5CW34"/>
    <dbReference type="OrthoDB" id="343641at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="238"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="283"/>
            <end position="298"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="480" mass="54487" checksum="B5EB671036F8540A" modified="2005-04-12" version="1">MIIYNEIEERTPRIEVGKKVIISPLKLELLDNGSNYSKTQSFNSINSTFHEMSQRGISSTESLEYQDKYVTPSILSDDNESDIERAKIVEEAAIVAEKLMSSQLSKINYETELRTMETRFPTRVNSPRYYNEKKEVMDRANRMLMKGRRECSSIPGFFQNKLGWFNCVENFFSVCNDEQIVEDNESCTIIETNPYFSPKKKSNADTNMKILEELKTLNLDSVTKNSTIGEGRKLAKKVTTNSTNEGRVQKTQPSKKLVNTEKSSIASKTKTDINSNNDKKTTQVKVSNKSLKPNNEISSNSKKVVISESNSYDIENDVFYLDDGAGYITFNSSILDFSEMEKRPKPQTTKTKSENNSEKTKIISLNPKDSDIENQKISVSSLVNMNSENAKKSPTMRKSNYAKTNKIDTIATEKIQNQVSSNDIPKKECKKKLKATKLKNSTELNGAIIENSNIDDQNIFNYSSNCIRGRMDYISTDVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW42</accession>
    <name>Q5CW42_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627077.1">
        <property type="nucleotide sequence ID" value="XM_627077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW42"/>
    <dbReference type="GeneID" id="3374603"/>
    <dbReference type="KEGG" id="cpv:cgd8_1710"/>
    <dbReference type="InParanoid" id="Q5CW42"/>
    <dbReference type="OrthoDB" id="341042at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="124" mass="13833" checksum="52BCA48B4973571E" modified="2005-04-12" version="1">MTEIEVALSFTSFLMLVLTSSIPNLYRYIALLLIELCSCIIVSILLIIKPKSNQRSLLPTIALISYSLINGFIGTILTIFTAFFLGAHLVDFGTIVLSLYFGLVTFRTCIFTGFKSLLVMIIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW62</accession>
    <name>Q5CW62_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">FH2 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_1500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627057.1">
        <property type="nucleotide sequence ID" value="XM_627057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW62"/>
    <dbReference type="STRING" id="353152.Q5CW62"/>
    <dbReference type="GeneID" id="3374586"/>
    <dbReference type="KEGG" id="cpv:cgd8_1500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1500"/>
    <dbReference type="InParanoid" id="Q5CW62"/>
    <dbReference type="OMA" id="MLAICEM"/>
    <dbReference type="OrthoDB" id="1668162at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="217"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="796"/>
            <end position="845"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="142"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="796"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="833"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="967" mass="107699" checksum="FD90E6091F03340A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW94</accession>
    <name>Q5CW94_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_1180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89673.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627025.1">
        <property type="nucleotide sequence ID" value="XM_627025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW94"/>
    <dbReference type="FunCoup" id="Q5CW94">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW94"/>
    <dbReference type="GeneID" id="3374638"/>
    <dbReference type="KEGG" id="cpv:cgd8_1180"/>
    <dbReference type="InParanoid" id="Q5CW94"/>
    <dbReference type="OMA" id="IRKPPIM"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="7">
        <location>
            <begin position="11"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="81"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="151"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="412"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="729"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89673.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="832" mass="93247" checksum="F6412217CED6C178" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWC6</accession>
    <name>Q5CWC6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">26S proteasome regulatory subunit S10b like AAA+ ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd8_840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626993.1">
        <property type="nucleotide sequence ID" value="XM_626993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWC6"/>
    <dbReference type="FunCoup" id="Q5CWC6">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWC6"/>
    <dbReference type="GeneID" id="3374429"/>
    <dbReference type="KEGG" id="cpv:cgd8_840"/>
    <dbReference type="InParanoid" id="Q5CWC6"/>
    <dbReference type="OMA" id="DHEPCVI"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000008">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000034">
        <property type="entry name" value="26S protease regulatory subunit 10B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="183"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="36"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="9"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK89665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="406" mass="45544" checksum="C81AB16A142DA95C" modified="2005-04-12" version="1" fragment="single">IVELGYSKADAEQTKMSGEDEHKNTLATYAQKVKEHRELEVSLKKKRMEIRELSKVYDKTEDDLKALQSVGQIIGEVLRHLDDEKCIVKASTGPRYVVGCRSKLDKSKLTSGTRVALDATTLTIMRRLPREVDPMVYNMLHEDPGSVSYSQVGGLNEQIREIREVIELPLTNPELFKRVGIKTPKGVLLYGPPGTGKTLLARAMASSMNCNFMKVVASAIVDKYIGESARVIREMFGYAKDHQPCVIFMDEIDAIGGKRFSQGTSADREIQRTLMELLNQLDGFDELGAVKIIMATNRPDVLDPALLRPGRLDRKVEIPLPNETSRVEILKIHSSKLAKQGEIDFDAICKLCDGFNGADMRNVCSEAGMFAIRAERDYIIEEDFLKAVRKLAENKKMEGNLDYEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWE4</accession>
    <name>Q5CWE4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_5420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90109.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627860.1">
        <property type="nucleotide sequence ID" value="XM_627860.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3375854"/>
    <dbReference type="KEGG" id="cpv:cgd6_5420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5420"/>
    <dbReference type="InParanoid" id="Q5CWE4"/>
    <dbReference type="OMA" id="ENEYRTV"/>
    <dbReference type="OrthoDB" id="342995at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255028" evidence="1">
        <location>
            <begin position="25"/>
            <end position="1316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90109.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1316" mass="146449" checksum="B8FC1A412ECEC448" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWG4</accession>
    <name>Q5CWG4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_5180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627840.1">
        <property type="nucleotide sequence ID" value="XM_627840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWG4"/>
    <dbReference type="GeneID" id="3375835"/>
    <dbReference type="KEGG" id="cpv:cgd6_5180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5180"/>
    <dbReference type="InParanoid" id="Q5CWG4"/>
    <dbReference type="OMA" id="RTHKEND"/>
    <dbReference type="OrthoDB" id="339725at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="735" mass="82315" checksum="FA37DB137D4EA571" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWH8</accession>
    <name>Q5CWH8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">methylated diphthine methylhydrolase</fullName>
            <ecNumber evidence="6">3.1.1.97</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_5020</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>diphthine methyl ester-[translation elongation factor 2] + H2O = diphthine-[translation elongation factor 2] + methanol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42656"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10173"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17790"/>
            <dbReference type="ChEBI" id="CHEBI:79005"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="EC" id="3.1.1.97"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Protein modification; peptidyl-diphthamide biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the DPH7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.97" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627826.1">
        <property type="nucleotide sequence ID" value="XM_627826.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWH8"/>
    <dbReference type="FunCoup" id="Q5CWH8">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWH8"/>
    <dbReference type="GeneID" id="3375920"/>
    <dbReference type="KEGG" id="cpv:cgd6_5020"/>
    <dbReference type="InParanoid" id="Q5CWH8"/>
    <dbReference type="OMA" id="CIDEPIM"/>
    <dbReference type="OrthoDB" id="273771at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061685">
        <property type="term" value="F:diphthine methylesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052415">
        <property type="entry name" value="Diphthine_MTase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46042:SF1">
        <property type="entry name" value="DIPHTHINE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 8" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="50"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="8">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00039131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="216" mass="25175" checksum="BFB131670486A511" modified="2005-04-12" version="1" fragment="single">PNSFESLNSNFRKTCYSISDGRVFIIRNSEIIENEFYAHPNTEVWTVSFLDPEGNLLATGADDCSLSLWDLRTSCIDEPIMKNKKSHSMGVTCIQKSNRNHQFWSGSYDETLRFWDFRMINSPIYEHKTNGGIWRINQFEDYLGMAQCYYGLEYLKLDPNLNVEKQYISVPNDSESQFSHNSIVYGIDTFRMNNTLFGFSCSFYDKTALIFQILEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWJ6</accession>
    <name>Q5CWJ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90065.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627808.1">
        <property type="nucleotide sequence ID" value="XM_627808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWJ6"/>
    <dbReference type="GeneID" id="3375810"/>
    <dbReference type="KEGG" id="cpv:cgd6_4810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4810"/>
    <dbReference type="InParanoid" id="Q5CWJ6"/>
    <dbReference type="OrthoDB" id="336132at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254317" evidence="1">
        <location>
            <begin position="28"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90065.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="108" mass="12303" checksum="3DC89D143B597252" modified="2005-04-12" version="1">MMSKKEFERLQAVILVCLLYLCIHVEGNGRNVTGFVPEFRNSRREPILTRAPPVTILGDPSISLTIPARKVCYKGSFDSKYNSCTYIDKNDEAVPIYKVSNMKDFQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWK5</accession>
    <name>Q5CWK5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Mrd1p like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_4710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627799.1">
        <property type="nucleotide sequence ID" value="XM_627799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWK5"/>
    <dbReference type="FunCoup" id="Q5CWK5">
        <property type="interactions" value="188"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWK5"/>
    <dbReference type="GeneID" id="3375802"/>
    <dbReference type="KEGG" id="cpv:cgd6_4710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4710"/>
    <dbReference type="InParanoid" id="Q5CWK5"/>
    <dbReference type="OMA" id="FNNTCIQ"/>
    <dbReference type="OrthoDB" id="439639at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12565">
        <property type="entry name" value="RRM1_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12320">
        <property type="entry name" value="RRM6_RBM19_RRM5_MRD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="17"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="287"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="491"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="602"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="715"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="125"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="206"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="126"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="212"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="245"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="806" mass="90413" checksum="FA812D46F7D10E76" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWL8</accession>
    <name>Q5CWL8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="14">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">cgd6_4550</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="14"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627786.1">
        <property type="nucleotide sequence ID" value="XM_627786.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWL8"/>
    <dbReference type="FunCoup" id="Q5CWL8">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWL8"/>
    <dbReference type="GeneID" id="3375791"/>
    <dbReference type="KEGG" id="cpv:cgd6_4550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4550"/>
    <dbReference type="InParanoid" id="Q5CWL8"/>
    <dbReference type="OMA" id="FVPCEHT"/>
    <dbReference type="OrthoDB" id="361536at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02658">
        <property type="entry name" value="Peptidase_C19B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016652">
        <property type="entry name" value="Ubiquitinyl_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041432">
        <property type="entry name" value="UBP13_Znf-UBP_var"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF10">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17807">
        <property type="entry name" value="zf-UBP_var"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016308">
        <property type="entry name" value="UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 14" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 14" id="KW-0645">Protease</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="9 14" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="7 14" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="10 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="18">
        <location>
            <begin position="161"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="17">
        <location>
            <begin position="331"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="16">
        <location>
            <begin position="691"/>
            <end position="732"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="549"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="741"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="742"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="11">
        <location>
            <position position="340"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="11">
        <location>
            <position position="861"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="188"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="205"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR016308-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAK90046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="921" mass="104508" checksum="9447C853FF572F67" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWQ8</accession>
    <name>Q5CWQ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_4120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627746.1">
        <property type="nucleotide sequence ID" value="XM_627746.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWQ8"/>
    <dbReference type="GeneID" id="3375760"/>
    <dbReference type="KEGG" id="cpv:cgd6_4120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4120"/>
    <dbReference type="InParanoid" id="Q5CWQ8"/>
    <dbReference type="OMA" id="SHHLAIF"/>
    <dbReference type="OrthoDB" id="338009at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="157" mass="18271" checksum="AF8123073E2F7B28" modified="2007-04-03" version="1">MSEKYWSRLLLDVATNVRSMHDGVSRMPFNYRENQKYPEYLDDIGALCACIRVFQDSLSPISQHLALHPYEKIYKDPISMPDLLTTSISDQMREEIKASESIVEELKGTDDFDQMFFKDMDRSQICNRINEFNNSIINISQTISDLDLLQFNDNTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWR4</accession>
    <name>Q5CWR4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_4060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMEM208 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90009.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627740.1">
        <property type="nucleotide sequence ID" value="XM_627740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWR4"/>
    <dbReference type="STRING" id="353152.Q5CWR4"/>
    <dbReference type="GeneID" id="3375754"/>
    <dbReference type="KEGG" id="cpv:cgd6_4060"/>
    <dbReference type="InParanoid" id="Q5CWR4"/>
    <dbReference type="OMA" id="STRLQQW"/>
    <dbReference type="OrthoDB" id="276296at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005773">
        <property type="term" value="C:vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006624">
        <property type="term" value="P:vacuolar protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008506">
        <property type="entry name" value="SND2/TMEM208"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13505:SF7">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN 208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05620">
        <property type="entry name" value="TMEM208_SND2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="82"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90009.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="129" mass="14675" checksum="622020191DBF5BA4" modified="2007-04-03" version="1">MAGQSAKRIAKEAAKYTSIYLYIMISCISIHFIFKGLYSPSKLIGKSGIGFAIISSIYFFTYSSIKSRLEVGVGYSMYQDVYILNSMVAILSVVSNYFWYIFLLIPIYIIYKIGKLIINWVFTPEPVSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWT7</accession>
    <name>Q5CWT7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative membrane protein with signal peptide and transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89988.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627717.1">
        <property type="nucleotide sequence ID" value="XM_627717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWT7"/>
    <dbReference type="GeneID" id="3375733"/>
    <dbReference type="KEGG" id="cpv:cgd6_3780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3780"/>
    <dbReference type="InParanoid" id="Q5CWT7"/>
    <dbReference type="OrthoDB" id="335959at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89988.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="209" mass="24469" checksum="1C17C4A64F28835C" modified="2007-04-03" version="1">MQRLTHVTCFFLIVCGWVINVFWPFVEGIGIRDLEIHGTSKNSQKNSSNITYSWFLENPNEFVEGESSNNDTNLIGTSIPYKIEDEDYKLTKDTSYYQRKHHDLLYLDQVGIWVKFHDYASNVDILVESTQTRNTLTDSSRKYGRLLEDQIKGNLSRNGSNEDLGLHSLRKNGRKSGWCLFHSFFQVVSKDWLLGWNFICNYFKEFILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX90</accession>
    <name>Q5CX90_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">dolichyl-diphosphooligosaccharide--protein glycotransferase</fullName>
            <ecNumber evidence="6">2.4.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">cgd6_2040</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>a di-trans,poly-cis-dolichyl diphosphooligosaccharide + L-asparaginyl-[protein] = N(4)-(oligosaccharide-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl-(1-&gt;4)-N-acetyl-beta-D-glucosaminyl)-L-asparaginyl-[protein] + a di-trans,poly-cis-dolichyl diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22980"/>
            <dbReference type="Rhea" id="RHEA-COMP:12804"/>
            <dbReference type="Rhea" id="RHEA-COMP:12805"/>
            <dbReference type="Rhea" id="RHEA-COMP:19506"/>
            <dbReference type="Rhea" id="RHEA-COMP:19509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:50347"/>
            <dbReference type="ChEBI" id="CHEBI:57497"/>
            <dbReference type="ChEBI" id="CHEBI:57570"/>
            <dbReference type="ChEBI" id="CHEBI:132529"/>
            <dbReference type="EC" id="2.4.99.18"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endomembrane system</location>
            <topology evidence="3">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the STT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.99.18" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627564.1">
        <property type="nucleotide sequence ID" value="XM_627564.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX90"/>
    <dbReference type="FunCoup" id="Q5CX90">
        <property type="interactions" value="418"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX90"/>
    <dbReference type="GeneID" id="3376021"/>
    <dbReference type="KEGG" id="cpv:cgd6_2040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2040"/>
    <dbReference type="InParanoid" id="Q5CX90"/>
    <dbReference type="OMA" id="TWYAIGT"/>
    <dbReference type="OrthoDB" id="10261066at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004579">
        <property type="term" value="F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003674">
        <property type="entry name" value="Oligo_trans_STT3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048999">
        <property type="entry name" value="STT3-PglB_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048307">
        <property type="entry name" value="STT3_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13872:SF1">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE SUBUNIT STT3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02516">
        <property type="entry name" value="STT3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21436">
        <property type="entry name" value="STT3-PglB_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14" id="KW-0464">Manganese</keyword>
    <keyword evidence="13 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 16" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="117"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="182"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="219"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="249"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="280"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="375"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="417"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="442"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="482"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="domain" description="Oligosaccharyl transferase STT3 N-terminal" evidence="17">
        <location>
            <begin position="28"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="STT3/PglB/AglB core" evidence="18">
        <location>
            <begin position="549"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00010810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00048829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF02516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF21436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAK89828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="722" mass="81898" checksum="8948AF258F49C20D" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXI6</accession>
    <name>Q5CXI6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pdr17p-like Sec14 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627468.1">
        <property type="nucleotide sequence ID" value="XM_627468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXI6"/>
    <dbReference type="GeneID" id="3376092"/>
    <dbReference type="KEGG" id="cpv:cgd6_950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_950"/>
    <dbReference type="InParanoid" id="Q5CXI6"/>
    <dbReference type="OMA" id="HEAYWEE"/>
    <dbReference type="OrthoDB" id="75724at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008526">
        <property type="term" value="F:phosphatidylinositol transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011074">
        <property type="entry name" value="CRAL/TRIO_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052578">
        <property type="entry name" value="PI_Transfer_CRAL-TRIO"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45824:SF29">
        <property type="entry name" value="GH16843P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01100">
        <property type="entry name" value="CRAL_TRIO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="176"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="393"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="393"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="422"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="440" mass="49760" checksum="9CF12ED7977CE0EA" modified="2007-04-03" version="1">MVNYKISPILSEWKKTPQGPGAKTEKEEKALSSLRQLLEVQNKAAENKQNLEKQKAANGLVKKQSTSEAVFDKIKHFASSAFKNKESCVISSVSSPNKPGKIIKTRLLLKAPLSPYELDWCTDACLLRYLRGYNLKVIKSFEALAKTIHFRRKYAPQFISPRNISSGNNVEGLIRYGLDKEGRPCIFMRAKYSDSNIDVSLVLNSLLYSMERACLYIDQVSTSDNKINLIVDFTGYKSTQQPPVSLSLKFAKAMVDHYPERLHRAFIIQPGWFFKAVWGLISPCIPGNTAEKFVLIDPESDGSESFNALKSYIEDKYLDKEWGGSCEDVFDPNEYWQKENTEFDKFCEFCQNNFYTPEHPIPVIDPNSKSAVKVPTDVDPTEVPQLAVALLDDEDIDPNEPVEDGGHQPGEPFKPLSQQQSEEIEENNDFDVLDDTNTSQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXJ0</accession>
    <name>Q5CXJ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627464.1">
        <property type="nucleotide sequence ID" value="XM_627464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXJ0"/>
    <dbReference type="STRING" id="353152.Q5CXJ0"/>
    <dbReference type="GeneID" id="3376089"/>
    <dbReference type="KEGG" id="cpv:cgd6_900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_900"/>
    <dbReference type="InParanoid" id="Q5CXJ0"/>
    <dbReference type="OMA" id="DNTHEGL"/>
    <dbReference type="OrthoDB" id="417506at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071567">
        <property type="term" value="F:deUFMylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012462">
        <property type="entry name" value="UFSP1/2_DUB_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48153:SF2">
        <property type="entry name" value="UFM1-SPECIFIC PROTEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07910">
        <property type="entry name" value="Peptidase_C78"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UFSP1/2/DUB catalytic" evidence="2">
        <location>
            <begin position="506"/>
            <end position="698"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07910"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="713" mass="83529" checksum="5E3FF58A3D436DF9" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXS4</accession>
    <name>Q5CXS4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical low complexity protein with coiled coil regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_5130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628656.1">
        <property type="nucleotide sequence ID" value="XM_628654.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXS4"/>
    <dbReference type="GeneID" id="3372088"/>
    <dbReference type="KEGG" id="cpv:cgd7_5130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5130"/>
    <dbReference type="InParanoid" id="Q5CXS4"/>
    <dbReference type="OMA" id="NERETWE"/>
    <dbReference type="OrthoDB" id="342770at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="674"/>
            <end position="731"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="764"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="928"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1189"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1451"/>
            <end position="1478"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1568"/>
            <end position="1599"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="684"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="794"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="928"/>
            <end position="1023"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1117"/>
            <end position="1133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1141"/>
            <end position="1150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1176"/>
            <end position="1189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1624" mass="190740" checksum="F249813409CFE8E3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY22</accession>
    <name>Q5CY22_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628558.1">
        <property type="nucleotide sequence ID" value="XM_628556.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY22"/>
    <dbReference type="GeneID" id="3372064"/>
    <dbReference type="KEGG" id="cpv:cgd7_4000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4000"/>
    <dbReference type="InParanoid" id="Q5CY22"/>
    <dbReference type="OrthoDB" id="342293at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="263"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="370" mass="42743" checksum="2E9356A82836EE8F" modified="2005-04-12" version="1">MYPLSPRNCIGTNQNSRAASSEIISGSSFAYPNSSNESFINVRDENNSNLLEFDSFKVQLNIDKSNSKVSGEELNENSTKLKLITTHHSHNLDSNIKDESSNNIRVKNNIYSDISIENNFSNFELKTEPYINLSKEQLYKIIYQKHDELQQMKLQLNEAKIKELNLGKNYELSIAKQNELKTINSNLENLVNQLRTKKSHQVNSIASRLKLGNYNDKIFEKLDNLLDSITKLKEYASLFTIEDQVDINEIKKLKSSIDNLTPSKEINTEIEYLKEERQQLIQLLTALSSNNNFYIDNNFCDNELRNENVKQVNISLCDQIQILEFKLKRSNEIHKKKLSKIKNMIELLEKSESITSPILQDIKNEVNTII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY39</accession>
    <name>Q5CY39_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Unconventional myosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_3790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90372.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628541.1">
        <property type="nucleotide sequence ID" value="XM_628539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY39"/>
    <dbReference type="SMR" id="Q5CY39"/>
    <dbReference type="FunCoup" id="Q5CY39">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY39"/>
    <dbReference type="GeneID" id="3372127"/>
    <dbReference type="KEGG" id="cpv:cgd7_3790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3790"/>
    <dbReference type="InParanoid" id="Q5CY39"/>
    <dbReference type="OMA" id="MTYGDIG"/>
    <dbReference type="OrthoDB" id="312459at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF270">
        <property type="entry name" value="MYOSIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="7">
        <location>
            <begin position="87"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="641"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90372.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="816" mass="91480" checksum="17B221ACF7D525D0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYB5</accession>
    <name>Q5CYB5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Low complexity protein witha potential C2C2 zinc ribbon</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_2980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628465.1">
        <property type="nucleotide sequence ID" value="XM_628463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYB5"/>
    <dbReference type="STRING" id="353152.Q5CYB5"/>
    <dbReference type="GeneID" id="3372281"/>
    <dbReference type="KEGG" id="cpv:cgd7_2980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2980"/>
    <dbReference type="InParanoid" id="Q5CYB5"/>
    <dbReference type="OMA" id="NEANIHE"/>
    <dbReference type="OrthoDB" id="342715at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="443" mass="50333" checksum="B1D0431653D78570" modified="2005-04-12" version="1">MEELINDIENISINSNNVDESNTKDPEKNDNFFDYEILLPTRNQLEDDSILSLTPVKDNDKELFKNCILCRDYSSPICKECSKHNSKTSRKSKLKKNKIIPDGKVKALAMQFENILPEVTNSSPSFSIVNDNFMLEKSEPAHFQADISINSIIEHTNVDNRDYLNTSLLGDQTNILSIDSENDNAKSKMAKNQLTPIIDPNLCEKIDPIKAIITSSNSYINIVGNTEIGNCASADTKVRSIATEINHLFECGFPENDLIFDQFESLNPLEQRALLLKWITEILKTSEASSKLSNNEFKEIIKILKSIVDELERNETYKISKSSPNNNSTEYQSILSHVFDEKDERLIIKRNGIQIPNTKNSIKLVNSKLQINISIPEDEEIEEERINELILNKYIYSSSNFESNSIIIDENSLSPKSEIVLDDEEIVGNSIKEIGNNFFGFFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYC9</accession>
    <name>Q5CYC9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_2830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628451.1">
        <property type="nucleotide sequence ID" value="XM_628449.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYC9"/>
    <dbReference type="GeneID" id="3372269"/>
    <dbReference type="KEGG" id="cpv:cgd7_2830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2830"/>
    <dbReference type="InParanoid" id="Q5CYC9"/>
    <dbReference type="OMA" id="EESTIEW"/>
    <dbReference type="OrthoDB" id="338842at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="797" mass="92317" checksum="9B4A6B990CE3391C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYI0</accession>
    <name>Q5CYI0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized conserved protein, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_2260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628400.1">
        <property type="nucleotide sequence ID" value="XM_628398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYI0"/>
    <dbReference type="STRING" id="353152.Q5CYI0"/>
    <dbReference type="GeneID" id="3372200"/>
    <dbReference type="KEGG" id="cpv:cgd7_2260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2260"/>
    <dbReference type="InParanoid" id="Q5CYI0"/>
    <dbReference type="OMA" id="MHLVRDM"/>
    <dbReference type="OrthoDB" id="10039147at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032469">
        <property type="term" value="P:endoplasmic reticulum calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012879">
        <property type="entry name" value="CCDC47"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883">
        <property type="entry name" value="ADIPOCYTE-SPECIFIC PROTEIN 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12883:SF0">
        <property type="entry name" value="PAT COMPLEX SUBUNIT CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07946">
        <property type="entry name" value="CCDC47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="295"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="295"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="323"/>
            <end position="332"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004167"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="332" mass="38816" checksum="BB6FCAAE6A7219D7" modified="2005-04-12" version="1">MIGLQELCEIYWMELIAFWVLLIMVIVLLRGIRSNYEVAINWFKSSQEFLESNFSRSALIKKSFWLDSWSQFDIFATGRKNCPFMYMNVICKPRQDLLTGILLQPLLRNYDKVYIEIPIEKMEPIMLLVCSKGELKSALIDYPEIEIHCSQKKINLSKNIVYANSNACVEYILTSGSFSKFISSQLAERLVNYIYISDQTTCPRLTNSYSKITSVLKACIRVPSKDDIDFMSHNNLNLNYLFKNILSLCETLQTLELPEKTIQHINNNRLQIEKTFSKMNNNGVNEKVEAKRREKIRSEAIKVSRMSPKEQKKYQEKKDKQQARSRIKLKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYI3</accession>
    <name>Q5CYI3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_2230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628397.1">
        <property type="nucleotide sequence ID" value="XM_628395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYI3"/>
    <dbReference type="GeneID" id="3371802"/>
    <dbReference type="KEGG" id="cpv:cgd7_2230"/>
    <dbReference type="InParanoid" id="Q5CYI3"/>
    <dbReference type="OMA" id="SWANICK"/>
    <dbReference type="OrthoDB" id="5566667at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049372">
        <property type="entry name" value="PPP1R21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21636">
        <property type="entry name" value="PPP1R21_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein phosphatase 1 regulatory subunit 21 C-terminal" evidence="2">
        <location>
            <begin position="739"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="11"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="130"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="647"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="733"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="834" mass="97334" checksum="327F56EE0229D504" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYK3</accession>
    <name>Q5CYK3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bub1p related protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_2000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
            <location evidence="1">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628377.1">
        <property type="nucleotide sequence ID" value="XM_628375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYK3"/>
    <dbReference type="STRING" id="353152.Q5CYK3"/>
    <dbReference type="GeneID" id="3371883"/>
    <dbReference type="KEGG" id="cpv:cgd7_2000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2000"/>
    <dbReference type="InParanoid" id="Q5CYK3"/>
    <dbReference type="OMA" id="RESIMYT"/>
    <dbReference type="OrthoDB" id="248495at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032991">
        <property type="term" value="C:protein-containing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051754">
        <property type="term" value="P:meiotic sister chromatid cohesion, centromeric"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015661">
        <property type="entry name" value="Bub1/Mad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030:SF4">
        <property type="entry name" value="BUB1 KINASE, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14030">
        <property type="entry name" value="MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0137">Centromere</keyword>
    <keyword evidence="2" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="5">
        <location>
            <begin position="436"/>
            <end position="778"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="850" mass="96877" checksum="42AAE8EF28836833" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYL1</accession>
    <name>Q5CYL1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">GINS subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_1920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GINS3/PSF3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628369.1">
        <property type="nucleotide sequence ID" value="XM_628367.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYL1"/>
    <dbReference type="FunCoup" id="Q5CYL1">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYL1"/>
    <dbReference type="GeneID" id="3371795"/>
    <dbReference type="KEGG" id="cpv:cgd7_1920"/>
    <dbReference type="InParanoid" id="Q5CYL1"/>
    <dbReference type="OMA" id="PIWLARE"/>
    <dbReference type="OrthoDB" id="10251744at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11713">
        <property type="entry name" value="GINS_A_psf3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021151">
        <property type="entry name" value="GINS_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010492">
        <property type="entry name" value="GINS_Psf3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038437">
        <property type="entry name" value="GINS_Psf3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22768:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05916">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GINS subunit" evidence="5">
        <location>
            <begin position="31"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF05916"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="144" mass="16568" checksum="763F886B192025B3" modified="2005-04-12" version="1" fragment="single">ILAGEILQLPIWLARELYSRGFVGIDYPDFLSSKMSNALRTDPCSVDLNNISPYFFQVSVIFLGLLQDELFLKVILESFRSRLEKLFLVSIYLHLPNSSESSKMNNDHTQVFLKSLTSIEKDMLEESSISYFQSANALYCRRVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYN6</accession>
    <name>Q5CYN6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Signal recognition particle 54 kDa protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd7_1640</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.4"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:19670"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="13">The M domain binds the 7SL RNA in presence of SRP19 and binds the signal sequence of presecretory proteins.</text>
    </comment>
    <comment type="domain">
        <text evidence="13">The NG domain, also named G domain, is a special guanosine triphosphatase (GTPase) domain, which binds GTP and forms a guanosine 5'-triphosphate (GTP)-dependent complex with a homologous NG domain in the SRP receptor subunit SRPRA. The two NG domains undergo cooperative rearrangements upon their assembly, which culminate in the reciprocal activation of the GTPase activity of one another. SRP receptor compaction upon binding with cargo-loaded SRP and GTPase rearrangement drive SRP-mediated cotranslational protein translocation into the ER.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the GTP-binding SRP family. SRP54 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628344.1">
        <property type="nucleotide sequence ID" value="XM_628342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYN6"/>
    <dbReference type="FunCoup" id="Q5CYN6">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYN6"/>
    <dbReference type="GeneID" id="3371788"/>
    <dbReference type="KEGG" id="cpv:cgd7_1640"/>
    <dbReference type="InParanoid" id="Q5CYN6"/>
    <dbReference type="OMA" id="GMTGQDA"/>
    <dbReference type="OrthoDB" id="10250817at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006616">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17875">
        <property type="entry name" value="SRP54_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000022">
        <property type="entry name" value="Signal recognition particle 54 kDa subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.140">
        <property type="entry name" value="Signal recognition particle SRP54, nucleotide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.30">
        <property type="entry name" value="Signal recognition particle, SRP54 subunit, M-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00306">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036891">
        <property type="entry name" value="Signal_recog_part_SRP54_M_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013822">
        <property type="entry name" value="Signal_recog_particl_SRP54_hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004125">
        <property type="entry name" value="Signal_recog_particle_SRP54_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036225">
        <property type="entry name" value="SRP/SRP_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022941">
        <property type="entry name" value="SRP54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006325">
        <property type="entry name" value="SRP54_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000897">
        <property type="entry name" value="SRP54_GTPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042101">
        <property type="entry name" value="SRP54_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01425">
        <property type="entry name" value="SRP54_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 54K PROTEIN SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11564:SF5">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00448">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02881">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02978">
        <property type="entry name" value="SRP_SPB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00962">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00963">
        <property type="entry name" value="SRP54_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47364">
        <property type="entry name" value="Domain of the SRP/SRP receptor G-proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47446">
        <property type="entry name" value="Signal peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00300">
        <property type="entry name" value="SRP54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 13" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11 13" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8 13" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="10 13" id="KW-0733">Signal recognition particle</keyword>
    <feature type="domain" description="SRP54-type proteins GTP-binding" evidence="14">
        <location>
            <begin position="284"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005450"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU364034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS00300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK90603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="515" mass="56924" checksum="87268F8300730A38" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYU7</accession>
    <name>Q5CYU7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">Putative Sec61 signal peptide plus 9 transmembrane domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd7_950</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Membrane</location>
            <topology evidence="10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the SecY/SEC61-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628283.1">
        <property type="nucleotide sequence ID" value="XM_628281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYU7"/>
    <dbReference type="FunCoup" id="Q5CYU7">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYU7"/>
    <dbReference type="GeneID" id="3371991"/>
    <dbReference type="KEGG" id="cpv:cgd7_950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_950"/>
    <dbReference type="InParanoid" id="Q5CYU7"/>
    <dbReference type="OMA" id="PMMRQMF"/>
    <dbReference type="OrthoDB" id="420669at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.3370.10:FF:000002">
        <property type="entry name" value="Transport Sec61 subunit alpha isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3370.10">
        <property type="entry name" value="SecY subunit domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002208">
        <property type="entry name" value="SecY/SEC61-alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030659">
        <property type="entry name" value="SecY_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023201">
        <property type="entry name" value="SecY_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019561">
        <property type="entry name" value="Translocon_Sec61/SecY_plug_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00967">
        <property type="entry name" value="3a0501s007"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006341">
        <property type="entry name" value="PRK08568.1-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10906">
        <property type="entry name" value="SECY/SEC61-ALPHA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10559">
        <property type="entry name" value="Plug_translocon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00344">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004557">
        <property type="entry name" value="SecY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103491">
        <property type="entry name" value="Preprotein translocase SecY subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00755">
        <property type="entry name" value="SECY_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00756">
        <property type="entry name" value="SECY_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 10" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 10" id="KW-0811">Translocation</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="118"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="146"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="175"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="286"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="441"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="Translocon Sec61/SecY plug" evidence="13">
        <location>
            <begin position="42"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF10559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK90569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="473" mass="52377" checksum="8F236CC1A393E5AE" modified="2005-04-12" version="1">MAKGLRFLNLIKPALCVIPEVSSPDRRVPFKERVLWTLISLFVFLVCCQIPLYGVLSSKSSDPFYWVRVILASNRGTLMELGISPIVTSSMVMQLLAGSKIIDVDQSLKEDRALFQGAQKLFGLLITLGEAVAYVISGMYGDIRTIGAWNAILIIIQLFFAGVVVILLDELMQKGYGLGSGISLFIATNICETIVWKAFSPTTINTGRGTEFEGAVIALFHLLFTKPDKISALREAFYRSHATNMTNLLATVLVFLIVIYFQGFRVDLAVKYQKVRGQQGSFPIKLFYTSNIPIILQTALVSNLYFFSQLLYRRFKSNMLVNILGQWQELDVGGQSIPVGGIAYYISPPNSLVDVVSDPIHTFFYISFVLISCALFSKTWIEVSGSSAKDVAKQLRDQQMIMKGYRDSSLVQVLNRYIPTAAAFGGMCIGALTIIADFLGAIGSGTGILLAVTIIFQYYEMFAKERESGNIVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ11</accession>
    <name>Q5CZ11_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conserved integral membrane protein with 4 transmembrane domains, possible plant or bacterial origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CCC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628219.1">
        <property type="nucleotide sequence ID" value="XM_628217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ11"/>
    <dbReference type="STRING" id="353152.Q5CZ11"/>
    <dbReference type="GeneID" id="3371764"/>
    <dbReference type="KEGG" id="cpv:cgd7_260"/>
    <dbReference type="InParanoid" id="Q5CZ11"/>
    <dbReference type="OMA" id="SRIGWLR"/>
    <dbReference type="OrthoDB" id="73465at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005384">
        <property type="term" value="F:manganese ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02434">
        <property type="entry name" value="Nodulin-21_like_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008217">
        <property type="entry name" value="Ccc1_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31851">
        <property type="entry name" value="FE(2+)/MN(2+) TRANSPORTER PCL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01988">
        <property type="entry name" value="VIT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="218"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="253"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="312" mass="35440" checksum="3BA0F7B0F009D0C6" modified="2005-04-12" version="1" fragment="single">LKDFIIAYLNEVKDWRKQEKLIGSVISRGQRKFNNFICLETRLINNEFFKQKYVLFSLVHKRYPHKEEHLGTQSELLKVIVFGGLDGIITIFSLVSGCVAAGFTTIQLFTICMGSLLADAFAMSVGEYVSSKAEKEFVHSEQEREKWEVENCPEEEISEMYNLYQLKYGFSEEDAQKMVDLTFKYKDFFISNMMFEELGLIIEQGDSSQPSPLKTATFMFFSFALFGLIPMLSFVSFKYIFSLSDLLNEFSQALSFSTACICCAVTLYVLGYVKGKFCNMPPIRSAITMLVSGLIPGTVSYSVAAFVTYLTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPN9</accession>
    <name>A3FPN9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PIN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_2290</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the UTP23/FCF1 family. FCF1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388385.1">
        <property type="nucleotide sequence ID" value="XM_001388348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPN9"/>
    <dbReference type="FunCoup" id="A3FPN9">
        <property type="interactions" value="493"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPN9"/>
    <dbReference type="GeneID" id="3371827"/>
    <dbReference type="KEGG" id="cpv:cgd7_2290"/>
    <dbReference type="InParanoid" id="A3FPN9"/>
    <dbReference type="OMA" id="GMMDCLL"/>
    <dbReference type="OrthoDB" id="76105at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09864">
        <property type="entry name" value="PIN_Fcf1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000004">
        <property type="entry name" value="rRNA-processing protein FCF1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037503">
        <property type="entry name" value="Fcf1_PIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002716">
        <property type="entry name" value="PIN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00670">
        <property type="entry name" value="PINc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="PIN" evidence="6">
        <location>
            <begin position="23"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00024026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="156" mass="18108" checksum="8149AB14A62E3590" modified="2007-04-03" version="1" fragment="single">YSFRPNVPSSLFFNYNNNLGPPFHILLDTNFINFSIQHKLDIFKGTMDCLVAKCIPCITDCVIGELEKMGHRYNLALKLARDPRFKRLHCLHKGTYADDCIVQRVTEHKCYIVGTNDTELKRRIRRIPGVPIMYVTNHKYSIERLPESLVSVPLKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPP6</accession>
    <name>A3FPP6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_3080</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51585.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388392.1">
        <property type="nucleotide sequence ID" value="XM_001388355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPP6"/>
    <dbReference type="STRING" id="353152.A3FPP6"/>
    <dbReference type="GeneID" id="3371834"/>
    <dbReference type="KEGG" id="cpv:cgd7_3080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3080"/>
    <dbReference type="InParanoid" id="A3FPP6"/>
    <dbReference type="OMA" id="SFTECND"/>
    <dbReference type="OrthoDB" id="5337378at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000306">
        <property type="entry name" value="IKS protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF138">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE IKS1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="265"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAZ51585.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="665" mass="77023" checksum="0C334FD85A18A3DE" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPT5</accession>
    <name>A3FPT5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Signal recognition particle receptor subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_1650</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SRP receptor beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388314.1">
        <property type="nucleotide sequence ID" value="XM_001388277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPT5"/>
    <dbReference type="FunCoup" id="A3FPT5">
        <property type="interactions" value="197"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPT5"/>
    <dbReference type="GeneID" id="3375939"/>
    <dbReference type="KEGG" id="cpv:cgd6_1650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1650"/>
    <dbReference type="InParanoid" id="A3FPT5"/>
    <dbReference type="OMA" id="FVICEVI"/>
    <dbReference type="OrthoDB" id="41266at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019009">
        <property type="entry name" value="SRP_receptor_beta_su"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09439">
        <property type="entry name" value="SRPRB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="29"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020256"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="191" mass="21919" checksum="B2973383DB77C167" modified="2007-04-03" version="1" fragment="single">MFWELLFYTIAIVIGVSLLHSLKFIDIGIYLANYIISIILFSIQGTKSQNIYSLIIGPSGSGKTTLFYKVKKNKTTRTTTSIVPGVTRIKDNRYLVDIPGNRRIINDFILKYLNNSVSIIFVIDSNDKSSFKDAAEILFSIIREIHNIKIYSNNDSETKKQIYRVLILFNKSDLITSRSISYIKDELERSM</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPT6</accession>
    <name>A3FPT6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ribosomal eL28/Mak16 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_1820</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MAK16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388315.1">
        <property type="nucleotide sequence ID" value="XM_001388278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPT6"/>
    <dbReference type="STRING" id="353152.A3FPT6"/>
    <dbReference type="GeneID" id="3375940"/>
    <dbReference type="KEGG" id="cpv:cgd6_1820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1820"/>
    <dbReference type="InParanoid" id="A3FPT6"/>
    <dbReference type="OMA" id="CPLANTK"/>
    <dbReference type="OrthoDB" id="10251342at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.390.110:FF:000001">
        <property type="entry name" value="Protein MAK16 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006958">
        <property type="entry name" value="Mak16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029004">
        <property type="entry name" value="Ribosomal_eL28/Mak16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405">
        <property type="entry name" value="MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23405:SF4">
        <property type="entry name" value="PROTEIN MAK16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04874">
        <property type="entry name" value="Mak16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01778">
        <property type="entry name" value="Ribosomal_L28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003352">
        <property type="entry name" value="MAK16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal eL28/Mak16" evidence="4">
        <location>
            <begin position="6"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="258" mass="30233" checksum="F9604BDB299C37CD" modified="2007-04-03" version="1" fragment="single">MNDPELIWNSVSNNFCSFKVKCDKTSFCRNEYNVTGLCNRTSCPLSNLLYATVIEHEGDCYLYMKTAERAHTPRYLWEKIKLSNNFLVAISQINDNLKNVYPEHQILKCKHRLTRIRQTLIRARKMALTVRPKLVPIKKKTERREASREHKALNAAKIENEIENELLLRLKEGLYDGIYNYPTNNFEKTLDNLENVTQDEVSNGDSLENELAEYIEGIDDDSEDELEAMHKHELREILSKKKKINLEYEVEEDIKMTS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPU9</accession>
    <name>A3FPU9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_2650</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388328.1">
        <property type="nucleotide sequence ID" value="XM_001388291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPU9"/>
    <dbReference type="FunCoup" id="A3FPU9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPU9"/>
    <dbReference type="GeneID" id="3375953"/>
    <dbReference type="KEGG" id="cpv:cgd6_2650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2650"/>
    <dbReference type="InParanoid" id="A3FPU9"/>
    <dbReference type="OMA" id="APRHFPW"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043183">
        <property type="entry name" value="DNJB2/6-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168:SF3">
        <property type="entry name" value="DNAJ HEAT SHOCK PROTEIN FAMILY (HSP40) MEMBER B2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45168">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="2"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="218"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="242"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="260"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="273" mass="30796" checksum="B584530C94E7AD50" modified="2007-04-03" version="1">MDYYEILEVKRDASTSEIKKSYRKLALKWHPDKNPDNREEAEEMFKKIAEAYEVLSDPEKRNRYDTYGADGVSADFSSDFHGFDRHFSMGHASRIFEEFFGTNNIFDIFSSFGEFPGFNEPSRSSRGFSRSRGSRLSPFDDLHSQIFSNFGLSGSGFGNMQSFSSSSFSSGMGFQGGVSKSVSTSTSVINGRVITRTKTTERLADGTVRETVQEIEEDGRGNRVIRNSDNSSGSSRNRMLRQGSSQEFNDGFSLSTGNLHRTRSHRQSRTQNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPW1</accession>
    <name>A3FPW1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">41-2 protein antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_3740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388340.1">
        <property type="nucleotide sequence ID" value="XM_001388303.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPW1"/>
    <dbReference type="FunCoup" id="A3FPW1">
        <property type="interactions" value="103"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPW1"/>
    <dbReference type="GeneID" id="3375965"/>
    <dbReference type="KEGG" id="cpv:cgd6_3740"/>
    <dbReference type="InParanoid" id="A3FPW1"/>
    <dbReference type="OMA" id="YMVKFDD"/>
    <dbReference type="OrthoDB" id="10254842at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990070">
        <property type="term" value="C:TRAPPI protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990071">
        <property type="term" value="C:TRAPPII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990072">
        <property type="term" value="C:TRAPPIII protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14943">
        <property type="entry name" value="TRAPPC5_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000002">
        <property type="entry name" value="Trafficking protein particle complex subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016696">
        <property type="entry name" value="TRAPP-I_su5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902">
        <property type="entry name" value="41-2 PROTEIN ANTIGEN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20902:SF0">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017479">
        <property type="entry name" value="TRAPP_I_complex_Trs31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="171" mass="19379" checksum="3596F0D363B2458A" modified="2007-04-03" version="1" fragment="single">INLSSFAFLFSEMVQYSLSCLKPGIRLEDKLHEMGISVGFKIVELISIRDKAHQKRETRILQILSFISQKCWKYLFGHTGDLLKGQESDDEYMINDKNLLLNKFISVPRDLEHINCGAYAAGIVSGILDSSEFPANVTAHTTEDTPNNYSTTILIKFDKSVLLRDKSIQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ70</accession>
    <name>A3FQ70_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CysQ, sulfite synthesis pathway protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_1810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>1D-myo-inositol 1,3,4-trisphosphate + H2O = 1D-myo-inositol 3,4-bisphosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:70319"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58414"/>
            <dbReference type="ChEBI" id="CHEBI:83241"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:70320"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15553"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58282"/>
            <dbReference type="ChEBI" id="CHEBI:58469"/>
            <dbReference type="EC" id="3.1.3.57"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="6">
            <dbReference type="Rhea" id="RHEA:15554"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the inositol monophosphatase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388206.1">
        <property type="nucleotide sequence ID" value="XM_001388169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ70"/>
    <dbReference type="STRING" id="353152.A3FQ70"/>
    <dbReference type="GeneID" id="3373448"/>
    <dbReference type="KEGG" id="cpv:cgd2_1810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:Cgd2_1810"/>
    <dbReference type="InParanoid" id="A3FQ70"/>
    <dbReference type="OMA" id="NTCYYAN"/>
    <dbReference type="OrthoDB" id="10254945at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004441">
        <property type="term" value="F:inositol-1,4-bisphosphate 1-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01638">
        <property type="entry name" value="CysQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.190.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.540.10">
        <property type="entry name" value="Fructose-1,6-Bisphosphatase, subunit A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050725">
        <property type="entry name" value="CysQ/Inositol_MonoPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020583">
        <property type="entry name" value="Inositol_monoP_metal-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000760">
        <property type="entry name" value="Inositol_monophosphatase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43028:SF5">
        <property type="entry name" value="3'(2'),5'-BISPHOSPHATE NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00459">
        <property type="entry name" value="Inositol_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00377">
        <property type="entry name" value="IMPHPHTASES"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56655">
        <property type="entry name" value="Carbohydrate phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00629">
        <property type="entry name" value="IMP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0452">Lithium</keyword>
    <keyword evidence="4 7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <position position="87"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="107"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="110"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00044465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR600760-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="314" mass="35765" checksum="15DEDE67A36A8F47" modified="2007-04-03" version="1" fragment="single">MSLDEFNKLCYETNLDSKVVISAREVVEIGFLASKVIMEIYKNIDAELRINYKDKDNSPVTTADLNANEIICAKLSSKWPQIPIISEESETDTWENRQKYKICWLIDPLDGTKEFLRRNGEFTVNIGLCENGKPTLGVVSIPNTGISFFSFNNLGGAYKIATLNSSNVICGKTSLEFIPKSNKPFPNNGVIRILKSHNYKCPILDLFSEKFFQNNIKIPFGSSIKFIELIESRADIYPRFHDCMEWDTCASHIIIRQTCGDIYKLETFFSGSETQFKLGEPLTYNKEVLINPYFVAANEKVIETLRNRILSKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQD1</accession>
    <name>A3FQD1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SWI/SNF-related, matrix associated, actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_1330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388153.1">
        <property type="nucleotide sequence ID" value="XM_001388116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQD1"/>
    <dbReference type="FunCoup" id="A3FQD1">
        <property type="interactions" value="111"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQD1"/>
    <dbReference type="GeneID" id="3371489"/>
    <dbReference type="KEGG" id="cpv:cgd1_1330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1330"/>
    <dbReference type="InParanoid" id="A3FQD1"/>
    <dbReference type="OMA" id="CCKAKLH"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="4">
        <location>
            <begin position="205"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="5">
        <location>
            <begin position="656"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="462"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="502"/>
            <end position="529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="807" mass="93699" checksum="C0CBA24A494ACDE5" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQG8</accession>
    <name>A3FQG8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Fringe-like glycosyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd5_540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388252.1">
        <property type="nucleotide sequence ID" value="XM_001388215.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQG8"/>
    <dbReference type="GeneID" id="3373029"/>
    <dbReference type="KEGG" id="cpv:cgd5_540"/>
    <dbReference type="InParanoid" id="A3FQG8"/>
    <dbReference type="OMA" id="INQLWAN"/>
    <dbReference type="OrthoDB" id="421979at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003378">
        <property type="entry name" value="Fringe-like_glycosylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10811">
        <property type="entry name" value="FRINGE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02434">
        <property type="entry name" value="Fringe"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="384"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="10">
        <location>
            <begin position="206"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="domain" description="Fringe-like glycosyltransferase" evidence="10">
        <location>
            <begin position="274"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="507" mass="59910" checksum="F878A0B6A6BA737E" modified="2007-04-03" version="1" fragment="single">NKSILDILLIDNKIPKDNVYYLSENIPYKYPQDTLLLPILFRYVKESNNNNFDWFFIINSYTRFNPILLNELLFKLNKEQTIFEKIQNVPNISSNIKSPNNNFIGVQINDNVPSIVHHYNLDKNFKYPFHHSGYAIRRFTIESLQVSIKSSSNYINNKNNYKIYTDVNFEVCYFIMSLLLIIIKLINLLCIIFTSLNNINQKYIINPNEVVIAIKTTQKYHNNRISQINQLWANKKYLNYNSINSNPYCKNYFSSISHLIKPFNDKSIHIDILSDHNDIINNIPINDLKTGNQSNGHCLKLYSIIHFLYNKYIINNINSNYKIKYFALVDDDTLIIPFSLLNSLTYINHQYNDNDHFDLYLGLRYSFGSIIDNWSIDYITGKFYLFYLFIYYYYFFFFTIXLGGGGXIINSNXLSXLAKXKGXVKILECICNKPDEPDDMALGRWFKFLNIKAINFNGFHQAESIHYHSYYNYFSHIISFHKIESNIYNTAQKYNPKIFNLLYPXIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQG9</accession>
    <name>A3FQG9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Beta-Casp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51275.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388253.1">
        <property type="nucleotide sequence ID" value="XM_001388216.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQG9"/>
    <dbReference type="STRING" id="353152.A3FQG9"/>
    <dbReference type="GeneID" id="3373028"/>
    <dbReference type="KEGG" id="cpv:cgd5_550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_550"/>
    <dbReference type="InParanoid" id="A3FQG9"/>
    <dbReference type="OMA" id="KHDINDA"/>
    <dbReference type="OrthoDB" id="343043at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032039">
        <property type="term" value="C:integrator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034472">
        <property type="term" value="P:snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10890">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022712">
        <property type="entry name" value="Beta_Casp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027074">
        <property type="entry name" value="Integrator_9su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46094:SF1">
        <property type="entry name" value="INTEGRATOR COMPLEX SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01027">
        <property type="entry name" value="Beta-Casp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Beta-Casp" evidence="6">
        <location>
            <begin position="593"/>
            <end position="723"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="128"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="524"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="128"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="531"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51275.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1002" mass="116091" checksum="DD8C8B2485BBB991" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQK3</accession>
    <name>A3FQK3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Co-chaperone GrpE, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_3510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GrpE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388287.1">
        <property type="nucleotide sequence ID" value="XM_001388250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQK3"/>
    <dbReference type="FunCoup" id="A3FQK3">
        <property type="interactions" value="213"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQK3"/>
    <dbReference type="GeneID" id="3373333"/>
    <dbReference type="KEGG" id="cpv:cgd5_3510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3510"/>
    <dbReference type="InParanoid" id="A3FQK3"/>
    <dbReference type="OMA" id="PHRHQAI"/>
    <dbReference type="OrthoDB" id="201635at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000774">
        <property type="term" value="F:adenyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042803">
        <property type="term" value="F:protein homodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00446">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.20.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.22.10">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01151">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000740">
        <property type="entry name" value="GrpE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013805">
        <property type="entry name" value="GrpE_CC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009012">
        <property type="entry name" value="GrpE_head"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237">
        <property type="entry name" value="GRPE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21237:SF23">
        <property type="entry name" value="GRPE PROTEIN HOMOLOG, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01025">
        <property type="entry name" value="GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00773">
        <property type="entry name" value="GRPEPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58014">
        <property type="entry name" value="Coiled-coil domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51064">
        <property type="entry name" value="Head domain of nucleotide exchange factor GrpE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="63"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="234" mass="26134" checksum="1EB25E4CDBB09EBE" modified="2007-04-03" version="1">MLPFLTLARNLGAGSVRVGLVSNFSKGQLFFVGKNLLKNLGTRAISSKSKPTSVCEEEERAILEAEVAKIGVLQERIKTLEKDASGYIHKIEESKEKLLRSLAENENLRQRHRKDLEAAREYSISGFAKSLLDVSDSLSRALLSVDIENVDKNSIKSLYNGISMTYSSLEKVFEAHGIKRFQSLGKQFNPKEHEAVFEVKDTSKPKGQVCEELLPGYKIHDRVLRAAKVATIKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQQ3</accession>
    <name>A3FQQ3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">UBX domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_4030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAZ51215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388082.1">
        <property type="nucleotide sequence ID" value="XM_001388045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQQ3"/>
    <dbReference type="SMR" id="A3FQQ3"/>
    <dbReference type="FunCoup" id="A3FQQ3">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQQ3"/>
    <dbReference type="GeneID" id="3372414"/>
    <dbReference type="KEGG" id="cpv:cgd4_4030"/>
    <dbReference type="InParanoid" id="A3FQQ3"/>
    <dbReference type="OMA" id="SRCQRSC"/>
    <dbReference type="OrthoDB" id="25887at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061025">
        <property type="term" value="P:membrane fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031468">
        <property type="term" value="P:nuclear membrane reassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01770">
        <property type="entry name" value="UBX_UBXN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.210">
        <property type="entry name" value="SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036241">
        <property type="entry name" value="NSFL1C_SEP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012989">
        <property type="entry name" value="SEP_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001012">
        <property type="entry name" value="UBX_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333:SF20">
        <property type="entry name" value="NSFL1 COFACTOR P47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23333">
        <property type="entry name" value="UBX DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08059">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00789">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00553">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102848">
        <property type="entry name" value="NSFL1 (p97 ATPase) cofactor p47, SEP domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51399">
        <property type="entry name" value="SEP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50033">
        <property type="entry name" value="UBX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEP" evidence="2">
        <location>
            <begin position="20"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="UBX" evidence="1">
        <location>
            <begin position="124"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51399"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="202" mass="22456" checksum="A9B951CD6B1A6F4A" modified="2007-04-03" version="1" fragment="single">SGLAVENPGEYNSNGRGIPENAIKVVLYKNGFIIDDEEFRDISIPENEAFIRDIKNSVAPEELRKRSKNNQTINVAVDDRSSEIYVPPKKPMEMFSGSGNSLGQTRSSALQVNIESEAQVTVDKNKPTTNIQLRFHNGQKKVVTLNHDHTIADLHCIFMECAPVDGEYQLVSGFPPKEIKFDPSTTLKNAGLLQETISQNLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPM5</accession>
    <name>Q5CPM5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit D</fullName>
            <shortName evidence="5">eIF3d</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_270</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="6">Iowa type II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="5">The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit D family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625396.1">
        <property type="nucleotide sequence ID" value="XM_625396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPM5"/>
    <dbReference type="FunCoup" id="Q5CPM5">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPM5"/>
    <dbReference type="GeneID" id="3372359"/>
    <dbReference type="KEGG" id="cpv:cgd2_270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_270"/>
    <dbReference type="InParanoid" id="Q5CPM5"/>
    <dbReference type="OMA" id="FMDKRDN"/>
    <dbReference type="OrthoDB" id="16538at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098808">
        <property type="term" value="F:mRNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002191">
        <property type="term" value="P:cap-dependent translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03003">
        <property type="entry name" value="eIF3d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007783">
        <property type="entry name" value="eIF3d"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12399:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05091">
        <property type="entry name" value="eIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016281">
        <property type="entry name" value="EIF-3_zeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="RNA gate" evidence="5">
        <location>
            <begin position="278"/>
            <end position="292"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="545" mass="62158" checksum="073974BA7E52D711" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPM9</accession>
    <name>Q5CPM9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphoinositide 5-phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.36</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_230</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptojanin family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.36" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625392.1">
        <property type="nucleotide sequence ID" value="XM_625392.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPM9"/>
    <dbReference type="GeneID" id="3372363"/>
    <dbReference type="KEGG" id="cpv:cgd2_230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_230"/>
    <dbReference type="InParanoid" id="Q5CPM9"/>
    <dbReference type="OMA" id="CETAHEV"/>
    <dbReference type="OrthoDB" id="405996at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004439">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046856">
        <property type="term" value="P:phosphatidylinositol dephosphorylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046985">
        <property type="entry name" value="IP5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000300">
        <property type="entry name" value="IPPc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002013">
        <property type="entry name" value="SAC_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200">
        <property type="entry name" value="INOSITOL 5-PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11200:SF275">
        <property type="entry name" value="LD06095P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22669">
        <property type="entry name" value="Exo_endo_phos2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02383">
        <property type="entry name" value="Syja_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00128">
        <property type="entry name" value="IPPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50275">
        <property type="entry name" value="SAC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SAC" evidence="6">
        <location>
            <begin position="469"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="176"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="413"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="415"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013044"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1596" mass="182000" checksum="ADC79FE72A7C91CF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPN3</accession>
    <name>Q5CPN3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GOT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625388.1">
        <property type="nucleotide sequence ID" value="XM_625388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPN3"/>
    <dbReference type="FunCoup" id="Q5CPN3">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPN3"/>
    <dbReference type="GeneID" id="3372366"/>
    <dbReference type="KEGG" id="cpv:cgd2_190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_190"/>
    <dbReference type="InParanoid" id="Q5CPN3"/>
    <dbReference type="OMA" id="MWLTDAQ"/>
    <dbReference type="OrthoDB" id="204784at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045176">
        <property type="entry name" value="Got1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493">
        <property type="entry name" value="CGI-141-RELATED/LIPASE CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21493:SF9">
        <property type="entry name" value="GOLGI TRANSPORT PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="7"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="66"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004653"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025799"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="136" mass="15338" checksum="1FF1D0A6C5EEB0F7" modified="2005-04-12" version="1">MMDDNRKIGLGCCGLGMILIILGVLLFFDKALLTIGNFTFVAGLTLVLGLSKVTRFFLKPDKLKGTLFYFGGLFVIIVKSTIIGFILQMFGLFYLFNSFLPNIVSYIKLSPLSFILELPGIKQLSEWIYDQRRLPL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPT9</accession>
    <name>Q5CPT9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">B-box zinc finger domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_4060</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625425.1">
        <property type="nucleotide sequence ID" value="XM_625425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPT9"/>
    <dbReference type="STRING" id="353152.Q5CPT9"/>
    <dbReference type="GeneID" id="3372435"/>
    <dbReference type="KEGG" id="cpv:cgd4_4060"/>
    <dbReference type="InParanoid" id="Q5CPT9"/>
    <dbReference type="OMA" id="CDIKHHE"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19821">
        <property type="entry name" value="Bbox1_BBX-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049808">
        <property type="entry name" value="CONSTANS-like_Bbox1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31717">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31717:SF45">
        <property type="entry name" value="ZINC FINGER PROTEIN CONSTANS-LIKE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="5">
        <location>
            <begin position="207"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="5">
        <location>
            <begin position="259"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="459"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1090" mass="125066" checksum="F35DE14E5D5F3C4D" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ93</accession>
    <name>Q5CQ93_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_3670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625533.1">
        <property type="nucleotide sequence ID" value="XM_625533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ93"/>
    <dbReference type="GeneID" id="3372541"/>
    <dbReference type="KEGG" id="cpv:cgd5_3670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3670"/>
    <dbReference type="InParanoid" id="Q5CQ93"/>
    <dbReference type="OMA" id="KHIWIAL"/>
    <dbReference type="OrthoDB" id="338066at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="404" mass="46898" checksum="88A1D62347A353AF" modified="2005-04-12" version="1">MMKNVPEEQLSEIIESLNTIMLTNPDLYLKLAQEEFKNSKNLKILDVDIKYVVNSNFVFIDVSSPMTKNITKLGSIFRLELKIGFTKEMLKPQIKIGNQYREAETLEELNTSELTVSFDNFLEKDLKTEKGVKIIQVESVLHEMVFEKILKDEIFKYYMISIIHDRILLRLKAQIVPQNSETIIEKIISKAKAERLIPKSGTTDQIGFSKDEMTIYDLEFMKMKKQSIKHVLNLTCYTSYDELFNEKDTELKDYQKQLPIQTKVVEEVKSLNPKKTIELPTEWKELDHLCGIQIKNDYLPIKFKALINSGKLVFLFQFNGPNGFISNLNRANAHVSILSARVTYDSNTIININLEDFIQEYHHCSLCKPTFDYKNSILMCNQKLLKLSLTVNNICDAVKHKLKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQC6</accession>
    <name>Q5CQC6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_1250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625722.1">
        <property type="nucleotide sequence ID" value="XM_625722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQC6"/>
    <dbReference type="GeneID" id="3372645"/>
    <dbReference type="KEGG" id="cpv:cgd4_1250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1250"/>
    <dbReference type="InParanoid" id="Q5CQC6"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="101" mass="12109" checksum="6DD456E1ADE5B3C9" modified="2005-04-12" version="1">MKNEDQSIEFSFTKPLYFVLYDVIAIPEINENLHLKFIEDLYLKFKLGHKTVDEAHEQISCQYTFNVYEILYIGEKYGHYDIFFKVKNLVDDINNTFRIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQG4</accession>
    <name>Q5CQG4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cleavage stimulation factor 50 kDa subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd4_820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87655.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625684.1">
        <property type="nucleotide sequence ID" value="XM_625684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQG4"/>
    <dbReference type="STRING" id="353152.Q5CQG4"/>
    <dbReference type="GeneID" id="3372700"/>
    <dbReference type="KEGG" id="cpv:cgd4_820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_820"/>
    <dbReference type="InParanoid" id="Q5CQG4"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005848">
        <property type="term" value="C:mRNA cleavage stimulating factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031124">
        <property type="term" value="P:mRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044633">
        <property type="entry name" value="CstF1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44133:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="275"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="451"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="7">
        <location>
            <begin position="502"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="210"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00029851"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87655.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="737" mass="82731" checksum="E20ED082C58D73C9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQM0</accession>
    <name>Q5CQM0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625628.1">
        <property type="nucleotide sequence ID" value="XM_625628.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372716"/>
    <dbReference type="KEGG" id="cpv:cgd4_190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_190"/>
    <dbReference type="InParanoid" id="Q5CQM0"/>
    <dbReference type="OMA" id="WESITEL"/>
    <dbReference type="OrthoDB" id="344064at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="9"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2099" mass="246114" checksum="DE55F16B07AFCBE4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQN7</accession>
    <name>Q5CQN7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87741.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625965.1">
        <property type="nucleotide sequence ID" value="XM_625965.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQN7"/>
    <dbReference type="GeneID" id="3372913"/>
    <dbReference type="KEGG" id="cpv:cgd4_3910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3910"/>
    <dbReference type="InParanoid" id="Q5CQN7"/>
    <dbReference type="OrthoDB" id="339610at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87741.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="337" mass="38331" checksum="72762CA7E2221387" modified="2005-04-12" version="1">MIDPASAFCVGVYFLGVGVVGSVLYIPISLMRAIEYYHLDGDRRKNKRNTLLDGDSFLQNFGNIPNNNNGPIAINGNNSRNSNNQSICDDNSSLFFERPELLLIHKKKVLRDMLNGNNYLNNLVDFDDKSDYSFGAYERFTTYQNSTLNNDNTCNIGRSRSDLGNSRKYISKYRNSIIHGHESVRDILSTTTPSDKDENDNQLEIVIDDESAIFSLEYFKQIGFKKDYENHTTNYNSMYVCSSTNSTSSIISYEVGNSNHNINFPNRRGEFINDCKIVQVSQEHYSCVNTGLKNDDRDHHLKQKRSLSVSLNDAYFNKIKESAIIEEISAVHDILAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQS2</accession>
    <name>Q5CQS2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625930.1">
        <property type="nucleotide sequence ID" value="XM_625930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQS2"/>
    <dbReference type="FunCoup" id="Q5CQS2">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="GeneID" id="3372857"/>
    <dbReference type="KEGG" id="cpv:cgd4_3540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3540"/>
    <dbReference type="InParanoid" id="Q5CQS2"/>
    <dbReference type="OMA" id="INCWSAT"/>
    <dbReference type="OrthoDB" id="341336at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254271" evidence="1">
        <location>
            <begin position="22"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="240" mass="26829" checksum="AAB67BFD503B2E1F" modified="2005-04-12" version="1">MVSLRLLFIIALTALIQNVRSSNIILNENYTKISEKESIIESLEIIKREYDQGKNLTDLIKDLEHSEENRELFENMDTNTTEIISDSWDKIEAAMKNTTVVTPVAPFNSSSIGSCVKLASDVNIVFGSHRDEFQNAVAKCSRKALGSYKNTFRCISKLSFDGLKLSAQCNDCWAKTAHCGVKHCASQCLFNTCVAKCQKCSIRECSKQLNECAGTTWMPLPCALDPHKPIPDHFKANDPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQU5</accession>
    <name>Q5CQU5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GATA-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625907.1">
        <property type="nucleotide sequence ID" value="XM_625907.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQU5"/>
    <dbReference type="GeneID" id="3372777"/>
    <dbReference type="KEGG" id="cpv:cgd4_3280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3280"/>
    <dbReference type="InParanoid" id="Q5CQU5"/>
    <dbReference type="OrthoDB" id="343345at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.50.10">
        <property type="entry name" value="Erythroid Transcription Factor GATA-1, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013088">
        <property type="entry name" value="Znf_NHR/GATA"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="468"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="538"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="558" mass="59151" checksum="D74ABCA70438C3FD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR59</accession>
    <name>Q5CR59_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRp1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_1990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87883.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625793.1">
        <property type="nucleotide sequence ID" value="XM_625793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR59"/>
    <dbReference type="STRING" id="353152.Q5CR59"/>
    <dbReference type="GeneID" id="3372965"/>
    <dbReference type="KEGG" id="cpv:cgd4_1990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1990"/>
    <dbReference type="InParanoid" id="Q5CR59"/>
    <dbReference type="OMA" id="ISLIFCH"/>
    <dbReference type="OrthoDB" id="2019504at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010301">
        <property type="entry name" value="RRP1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026">
        <property type="entry name" value="NNP-1 PROTEIN NOVEL NUCLEAR PROTEIN 1 NOP52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13026:SF0">
        <property type="entry name" value="RIBOSOMAL RNA PROCESSING 1B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05997">
        <property type="entry name" value="Nop52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="357"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="470"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="369"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="472"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87883.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="493" mass="57127" checksum="BE893ACA9753CB0F" modified="2005-04-12" version="1">MKGNSENENELLMRLSKTLTSISPASRKKGLDIITRYISKHNNSMTRLQMLKIWKGLYYSMWLSDKVLIQREIAVNISQLQKRFEVKEYLFSFIEEFYLMMRFRWDGMDHYRMDKFTFLQRTMLAESLNLLSKKNFDPEFAKGLLDVYRRCLFVENIDNENSIGKKRKFLMISDHIGSGDEVDPSINSYSNRSTGIGVSLIFCKQFPQESVYLLYEQYKLIKENPSNKNLLNEYISSFFIEYSEFIINVIRTCTTHSTLTENIYSQLILKFVDFDSLLDQVVCDIDDLNINQEERNLISSFLLENIVNLMSKLHSSLSNLSKSNENSITQNKRNNIYSTMEKISNFLKNNVALSNSLPKVSKNKKRNSLNKQGSANYESKNEDKEKRVRFDMSKNVRMLLPDSISTSRALVKIFDKKSDMKGSNKINCILFRSSPNSDIQNDPELCSSDSCKNYNLNSLKNIEIISAEKALSKPSESNSSPSKSILKRRGINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR71</accession>
    <name>Q5CR71_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_1870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625781.1">
        <property type="nucleotide sequence ID" value="XM_625781.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR71"/>
    <dbReference type="GeneID" id="3372896"/>
    <dbReference type="KEGG" id="cpv:cgd4_1870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1870"/>
    <dbReference type="InParanoid" id="Q5CR71"/>
    <dbReference type="OMA" id="ENQFHIV"/>
    <dbReference type="OrthoDB" id="337041at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="222" mass="25606" checksum="E75AB7FF4973D64A" modified="2005-04-12" version="1">MNQLNKEIKLCGVFECNYTDTGGEIIHISPTNNYYSNLNINEEITKVLLPYYIDVNFDGISQFESQYHLVLRFNNTSEDIMVRLHRMYIVHEGIPVQVHNLNCYLLGKKTKISNDMKLSLLGSSSIKNKTQYFKSIRVVIKIENPENDASERFSNTNSIRILLDYFIDSNDLIASINVIQNDLKDINYIKDLPIEESEEALSETCSEDHSFTPILMPTMGHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRB9</accession>
    <name>Q5CRB9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNAj protein with possible transmembrane domain within C-terminal region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd5_3430</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626267.1">
        <property type="nucleotide sequence ID" value="XM_626267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRB9"/>
    <dbReference type="FunCoup" id="Q5CRB9">
        <property type="interactions" value="150"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRB9"/>
    <dbReference type="GeneID" id="3373056"/>
    <dbReference type="KEGG" id="cpv:cgd5_3430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3430"/>
    <dbReference type="InParanoid" id="Q5CRB9"/>
    <dbReference type="OMA" id="ARSREHN"/>
    <dbReference type="OrthoDB" id="552049at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015399">
        <property type="entry name" value="DUF1977_DnaJ-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09320">
        <property type="entry name" value="DUF1977"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="280"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="8">
        <location>
            <begin position="130"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="54"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="102"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="255"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="423" mass="48382" checksum="66E87B5F55629D14" modified="2005-04-12" version="1">MDSNKEEADRCVMLAKKAIHGGDLDKAKRLLEKANRMYPSQTITEMLINLKSCGSSTPEAQHNHHQTHHTHHHSHKASSPKNMHNHSSKGKKRNEDDDSRNSHSARSNFSSGSASESSESMCKRILKAKNFYDTLGVPKDADDAAIKKAYKKLALQLHPDKCKAPSAEEAFKRIALAFQTLSDAEKRKNYDTFGEDGPPMHSASGDVRYYQYHQGDGFLTPEDLFRMFFGGMPAEVSFNRQRFPNRSGHSRSHNRTYTTNMNSGGATSDGLHTGPIWQKIAGIIQILPVLLMLFLAIMGNFMPTLFPEDKPIYSFNRTREYSKQRWTGIHNVGFYTNPKANFDSKFPPNSSKLHELEVKIEIIHFTRECSVEERTILQDIAYAKYYQSKSKLKEIQNRSKPNCDKLKWLRDKYPSIYRQTMRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRG2</accession>
    <name>Q5CRG2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">C1p1p GTpase. Pre-mRNA cleavaage complex protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_2880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626224.1">
        <property type="nucleotide sequence ID" value="XM_626224.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRG2"/>
    <dbReference type="FunCoup" id="Q5CRG2">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRG2"/>
    <dbReference type="GeneID" id="3373240"/>
    <dbReference type="KEGG" id="cpv:cgd5_2880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2880"/>
    <dbReference type="InParanoid" id="Q5CRG2"/>
    <dbReference type="OMA" id="CILGVSY"/>
    <dbReference type="OrthoDB" id="258143at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051731">
        <property type="term" value="F:polynucleotide 5'-hydroxyl-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1030">
        <property type="entry name" value="Clp1, DNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045116">
        <property type="entry name" value="Clp1/Grc3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032324">
        <property type="entry name" value="Clp1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038239">
        <property type="entry name" value="Clp1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032319">
        <property type="entry name" value="CLP1_P"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755">
        <property type="entry name" value="CLEAVAGE/POLYADENYLATION FACTOR IA SUBUNIT CLP1P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12755:SF6">
        <property type="entry name" value="POLYRIBONUCLEOTIDE 5'-HYDROXYL-KINASE CLP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16573">
        <property type="entry name" value="CLP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16575">
        <property type="entry name" value="CLP1_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="3">
        <location>
            <begin position="198"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="601" mass="64600" checksum="BBF94C89A5218771" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRM8</accession>
    <name>Q5CRM8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">T8M16_190-plant like protein with RRM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_2200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626158.1">
        <property type="nucleotide sequence ID" value="XM_626158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRM8"/>
    <dbReference type="STRING" id="353152.Q5CRM8"/>
    <dbReference type="GeneID" id="3373109"/>
    <dbReference type="KEGG" id="cpv:cgd5_2200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2200"/>
    <dbReference type="InParanoid" id="Q5CRM8"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050886">
        <property type="entry name" value="RNA-binding_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024">
        <property type="entry name" value="GEO13361P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48024:SF25">
        <property type="entry name" value="UBP1-ASSOCIATED PROTEIN 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="97"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="185"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="600" mass="68614" checksum="0FE2C9271079A67F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRN6</accession>
    <name>Q5CRN6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Protein with conserved N-terminal localized cysteine-rich domain predicted archaeo-eukaryotic ribosomal protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd5_2110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELOF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88059.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626150.1">
        <property type="nucleotide sequence ID" value="XM_626150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRN6"/>
    <dbReference type="STRING" id="353152.Q5CRN6"/>
    <dbReference type="GeneID" id="3373117"/>
    <dbReference type="KEGG" id="cpv:cgd5_2110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2110"/>
    <dbReference type="InParanoid" id="Q5CRN6"/>
    <dbReference type="OMA" id="NCDKCQA"/>
    <dbReference type="OrthoDB" id="445983at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008023">
        <property type="term" value="C:transcription elongation factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.190:FF:000001">
        <property type="entry name" value="Transcription elongation factor 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007808">
        <property type="entry name" value="Elf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038567">
        <property type="entry name" value="T_Elf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20934:SF0">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05129">
        <property type="entry name" value="Zn_ribbon_Elf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="11" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="137"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="162"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="195"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="228"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003357"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88059.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="248" mass="28364" checksum="ED05281C5B640011" modified="2005-04-12" version="1">MGKRKTKKVEVKKSKVPKLDKEFNCPFCNNVKTVGVRMNHKERLGHLSCRVCGVEYTSRIGKFDEAVDIYSNWIDKCYEVNSMEQSTSSSAVEQPILSEDYALTGHSGDNKISQGLGNGDLANNMIYSRNQKKISFTMDDDVNEDRYSNENSSRGLRRMKEDEEDDYDDLRDFIVNDDEEEAKDNDNSKQQPKSSNDEIIEKMKKDLEINKSRKIKEDSGVFDINNITKSSSMPKSFTVNEDDGLFSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRQ6</accession>
    <name>Q5CRQ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">LETM1/MRS7 family protein with a transmembrane region at the N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd5_1870</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626130.1">
        <property type="nucleotide sequence ID" value="XM_626130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRQ6"/>
    <dbReference type="STRING" id="353152.Q5CRQ6"/>
    <dbReference type="GeneID" id="3373275"/>
    <dbReference type="KEGG" id="cpv:cgd5_1870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1870"/>
    <dbReference type="InParanoid" id="Q5CRQ6"/>
    <dbReference type="OMA" id="WHHFKDE"/>
    <dbReference type="OrthoDB" id="275278at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030003">
        <property type="term" value="P:intracellular monoatomic cation homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033122">
        <property type="entry name" value="LETM1-like_RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044202">
        <property type="entry name" value="LETM1/MDM38-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009">
        <property type="entry name" value="LEUCINE ZIPPER-EF-HAND CONTAINING TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14009:SF1">
        <property type="entry name" value="MITOCHONDRIAL PROTON_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07766">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51758">
        <property type="entry name" value="LETM1_RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 7" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="domain" description="Letm1 RBD" evidence="9">
        <location>
            <begin position="121"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51758"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="303" mass="35597" checksum="0B6EB4B7CB8CE237" modified="2005-04-12" version="1">MIRFKRVVEGIPRNSYLRGFNHALKEGFNWSVCGFRHFFYNLKYTNSLIQKRILGNGLTFNEKQLVKTTIKDTIKIIPFSFFIIVPFAEFGLPFVIKLFPNMLPSTFALKSTKERDDNILNKRKIELLEFHSLIQNVISNLKKSDNSDIISGVKSLEKIHLELLEKNKLDQEELGKVISGPIKEEFKLENLNIETLQSISRVMGVPSTRSKLLLMLRIRYRILKLKNEDKDILWDGTDQMDKQQLQKALISRFIDRNKKEYSIEEYKKLLMNWIRLSSMKQLPLSLMLWIQATRLISDNIDKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRY1</accession>
    <name>Q5CRY1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Arfgap'arfgap like finger domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_1040</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2007-02" db="PDB data bank">
            <title>Crystal structure of putative GTPase activating protein for ADP ribosylation factor from Cryptosporidium parvum (cgd5_1040).</title>
            <authorList>
                <person name="Dong A."/>
                <person name="Lew J."/>
                <person name="Zhao Y."/>
                <person name="Hassanali A."/>
                <person name="Lin L."/>
                <person name="Ravichandran M."/>
                <person name="Wasney G."/>
                <person name="Vedadi M."/>
                <person name="Kozieradzki I."/>
                <person name="Bochkarev A."/>
                <person name="Edwards A.M."/>
                <person name="Arrowsmith C.H."/>
                <person name="Weigelt J."/>
                <person name="Sundstrom M."/>
                <person name="Hui R."/>
                <person name="Qiu W."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 1-137 IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626055.1">
        <property type="nucleotide sequence ID" value="XM_626055.1"/>
    </dbReference>
    <dbReference type="PDB" id="2OWA">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B=1-137"/>
    </dbReference>
    <dbReference type="PDBsum" id="2OWA"/>
    <dbReference type="AlphaFoldDB" id="Q5CRY1"/>
    <dbReference type="SMR" id="Q5CRY1"/>
    <dbReference type="STRING" id="353152.Q5CRY1"/>
    <dbReference type="GeneID" id="3373077"/>
    <dbReference type="KEGG" id="cpv:cgd5_1040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1040"/>
    <dbReference type="InParanoid" id="Q5CRY1"/>
    <dbReference type="OrthoDB" id="10266696at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CRY1"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048205">
        <property type="term" value="P:COPI coating of Golgi vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08959">
        <property type="entry name" value="ArfGap_ArfGap1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.150">
        <property type="entry name" value="Arf GTPase activating protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037278">
        <property type="entry name" value="ARFGAP/RecO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001164">
        <property type="entry name" value="ArfGAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038508">
        <property type="entry name" value="ArfGAP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686:SF4">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45686">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR GTPASE ACTIVATING PROTEIN 3, ISOFORM H-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01412">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00405">
        <property type="entry name" value="REVINTRACTNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00105">
        <property type="entry name" value="ArfGap"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57863">
        <property type="entry name" value="ArfGap/RecO-like zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50115">
        <property type="entry name" value="ARFGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="2 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Arf-GAP" evidence="6">
        <location>
            <begin position="23"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="41"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="61"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="2OWA"/>
        </source>
    </evidence>
    <sequence length="215" mass="24576" checksum="919626586953AFC0" modified="2005-04-12" version="1">MNISNLINADVDEKGFVSDKLRDNFFQIVRNRPENRTCFDCESRNPTWLSLSFAVFICLNCSSDHRKMGVHISFVRSSDLDKFTPIQLVRMDIGGNGRARNYFKQVLGVNFSPKTKEYASSICGRQYKQILDSEISEFDNLSPKNPNEFVLIDRDNYTANPEKVDTQSTGNVQTIKFNSMPSTVGKYNNIQKQGSLINQKGRRLDENFDFDSLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS07</accession>
    <name>Q5CS07_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Malic enzyme</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd5_750</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="7">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="7">Divalent metal cations. Prefers magnesium or manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the malic enzymes family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626029.1">
        <property type="nucleotide sequence ID" value="XM_626029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS07"/>
    <dbReference type="STRING" id="353152.Q5CS07"/>
    <dbReference type="GeneID" id="3373304"/>
    <dbReference type="KEGG" id="cpv:cgd5_750"/>
    <dbReference type="InParanoid" id="Q5CS07"/>
    <dbReference type="OMA" id="YPNMVVQ"/>
    <dbReference type="OrthoDB" id="5365701at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004471">
        <property type="term" value="F:malate dehydrogenase (decarboxylating) (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006108">
        <property type="term" value="P:malate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05312">
        <property type="entry name" value="NAD_bind_1_malic_enz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10380">
        <property type="entry name" value="Malic enzyme, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046346">
        <property type="entry name" value="Aminoacid_DH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015884">
        <property type="entry name" value="Malic_enzyme_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012301">
        <property type="entry name" value="Malic_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037062">
        <property type="entry name" value="Malic_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012302">
        <property type="entry name" value="Malic_NAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001891">
        <property type="entry name" value="Malic_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010052">
        <property type="entry name" value="PRK13529.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406">
        <property type="entry name" value="MALIC ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23406:SF32">
        <property type="entry name" value="NADP-DEPENDENT MALIC ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00390">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03949">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000106">
        <property type="entry name" value="ME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00072">
        <property type="entry name" value="MALOXRDTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01274">
        <property type="entry name" value="malic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00919">
        <property type="entry name" value="Malic_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53223">
        <property type="entry name" value="Aminoacid dehydrogenase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00331">
        <property type="entry name" value="MALIC_ENZYMES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Malic enzyme N-terminal" evidence="10">
        <location>
            <begin position="130"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="Malic enzyme NAD-binding" evidence="9">
        <location>
            <begin position="324"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="5">
        <location>
            <position position="228"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="210"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="299"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="300"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="323"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="466"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="511"/>
        </location>
        <ligand>
            <name>(S)-malate</name>
            <dbReference type="ChEBI" id="CHEBI:15589"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008785"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000106-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM01274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="614" mass="68864" checksum="3367531771DCAA9F" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS40</accession>
    <name>Q5CS40_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal peptide containing protein with threonine stretches,possible mucin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88179.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625996.1">
        <property type="nucleotide sequence ID" value="XM_625996.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS40"/>
    <dbReference type="GeneID" id="3373186"/>
    <dbReference type="KEGG" id="cpv:cgd5_340"/>
    <dbReference type="InParanoid" id="Q5CS40"/>
    <dbReference type="OrthoDB" id="343653at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254183" evidence="1">
        <location>
            <begin position="20"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88179.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="322" mass="36754" checksum="0AA0C77BC78F7ABE" modified="2005-04-12" version="1">MHSLKQIIILVFIIGLTLLNGIESKGYRESRINKVIKIETRSKSNAKSDSNDTCNVNTMHISNFMNTSRWRRIRNKLGTGWDDELIPPLIFCVKILDKPTNTSNSCNRNTFDLILNDGIHKSKNSVVIATVSDILKGEEKCIFVSPCEILRRIYWNDNNFTNSISNLEFNINSTFESISPNQRFISVISIKGLARSLKKAKNPWDNHLKLVQKFKNVQALSLFIPYKPHSKSFISDTCIVKPKVTSIFYGKNKPSVCKFNNCMWNIWIGQLSGEFVNERCTIGKASSKGDYIVGWFSPXXNXFXNSXXSEIXXAMEFTRRSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS42</accession>
    <name>Q5CS42_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Carboxylesterase, lysophospholipase, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625994.1">
        <property type="nucleotide sequence ID" value="XM_625994.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS42"/>
    <dbReference type="SMR" id="Q5CS42"/>
    <dbReference type="STRING" id="353152.Q5CS42"/>
    <dbReference type="ESTHER" id="crypv-q5cs42">
        <property type="family name" value="LYsophospholipase_carboxylesterase"/>
    </dbReference>
    <dbReference type="GeneID" id="3373188"/>
    <dbReference type="KEGG" id="cpv:cgd5_320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_320"/>
    <dbReference type="InParanoid" id="Q5CS42"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF67">
        <property type="entry name" value="PHOSPHOLIPASE_CARBOXYLESTERASE SUPERFAMILY (AFU_ORTHOLOGUE AFUA_5G09340)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254315" evidence="3">
        <location>
            <begin position="18"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="4">
        <location>
            <begin position="289"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="51"/>
            <end position="78"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="473" mass="55883" checksum="8A930C26FF6C3122" modified="2005-04-12" version="1">MKLITFLFIIIIKAVYSKNSTIYIEKIDTHNIPSLTYYSPLLFFSKDQNSLIHLERTLKRLRLINKNLKEKAKSEALNYEDPYLNPERFTKSKIWRFFNYFRLKRKKKKQPRHPGKIAKAFSFEEYLILNYHQNLNFTNQTDITTLKANETYYYGINQTIQDNETTEFNRCTSTKCHSLDNFDLYSNSVTPGDYSSILEIFKPRRPKNIIISLLGVSSDQIYLEAFKYTYYPFISQMKMYGDQFRKDTGIIFVHPFLRKFKPIGSIKWVYRYAWADFAFGVRLKQVNLKQWMYSVESVIMLINYLIEVEKYDPKRIFIYGYSQGGALSLSVTLRTKYVLGGLVSTASFLPERAMKKLISMDPLITNEGLKTPILLTYCNPDFVFPFRSAKKDIKYLINNFKANIKNTLMLGEGHSCLTKYSMVYIDWIYSVLSNYKDSNYKPKEFSYKLLDINNDFQEFYNFGSIEEKKSNNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS63</accession>
    <name>Q5CS63_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_80</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625973.1">
        <property type="nucleotide sequence ID" value="XM_625973.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS63"/>
    <dbReference type="GeneID" id="3373319"/>
    <dbReference type="KEGG" id="cpv:cgd5_80"/>
    <dbReference type="InParanoid" id="Q5CS63"/>
    <dbReference type="OMA" id="KERYHNG"/>
    <dbReference type="OrthoDB" id="342583at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="496" mass="59602" checksum="D35604F798535DA7" modified="2005-04-12" version="1" fragment="single">NKILNMSELYNKIDKPENSTDSLIFNEYSNEFNYPEVDSAIKKAHYFDRIETERNMIYLEEMINNFQKNTEVLDHLETKKISNEISKDKKMICSMLYDIPNFVKQLSNHNQGDSESEYDCLSFESSEFQNKENEINQNINLNTNKYKYLIFKERYHNGNYYDKYGRFCGFFNNGIFHSFYYYYQQYLNSNNFLNEINENETSLSLKESENTFNHQVQDYNQEYYSQENEIKPELEEYEHKIDCNEKNKNTQIISDFQGSHLKECKQMSKIQEILISEIKEYQNRICKEEAFDNENLKFFGYNTESNLEILIENQKNHEQKQNAKSLFQIISKEELKYIYCIILKFIYQSKTKYCQEKAFTEIPLINSLLNLNKESSEINLLRENCENENVDYESSELCNKEQQNKILISQNEFVEYNHHQFEYIKLINEIGGIPNDKQPCMEEINQDLEKVRDDELEQREIEEHSNLQILDFENILDFDFEDNEIECIGIKKIKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS82</accession>
    <name>Q5CS82_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ankyrin repeat protein with over 9 transmembrane domains at C-terminus, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_3740</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628185.1">
        <property type="nucleotide sequence ID" value="XM_628185.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS82"/>
    <dbReference type="GeneID" id="3371513"/>
    <dbReference type="KEGG" id="cpv:cgd1_3740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3740"/>
    <dbReference type="InParanoid" id="Q5CS82"/>
    <dbReference type="OMA" id="INTWILA"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198">
        <property type="entry name" value="ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24198:SF165">
        <property type="entry name" value="ANKYRIN REPEAT-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254902" evidence="6">
        <location>
            <begin position="19"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="893"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="946"/>
            <end position="968"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="974"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1094"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1139"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1263"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1301"/>
            <end position="1324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="1385"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="216"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="249"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="776"/>
            <end position="809"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="786"/>
            <end position="809"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1407" mass="160524" checksum="529079B680AF2D1D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSF8</accession>
    <name>Q5CSF8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_2900</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628109.1">
        <property type="nucleotide sequence ID" value="XM_628109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSF8"/>
    <dbReference type="GeneID" id="3371718"/>
    <dbReference type="KEGG" id="cpv:cgd1_2900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2900"/>
    <dbReference type="InParanoid" id="Q5CSF8"/>
    <dbReference type="OMA" id="SETHSIA"/>
    <dbReference type="OrthoDB" id="340569at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="590" mass="68213" checksum="DE3DF33BAC3D535E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSJ0</accession>
    <name>Q5CSJ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2510</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628077.1">
        <property type="nucleotide sequence ID" value="XM_628077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSJ0"/>
    <dbReference type="GeneID" id="3371699"/>
    <dbReference type="KEGG" id="cpv:cgd1_2510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2510"/>
    <dbReference type="InParanoid" id="Q5CSJ0"/>
    <dbReference type="OMA" id="SANNDFM"/>
    <dbReference type="OrthoDB" id="340887at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="292" mass="32571" checksum="CE9B299671121BC5" modified="2005-04-12" version="1">MLFKKIYKCIFSHEIDINEAVPYVACAAIKEPWSILSLDISFKEKKKNSKITIGLYNILLLLLILLVFLLILFSGGITIGQMAPPPIFIGNIYGLPIKTDSLTVSADGTFIATLKMPVYNKSLLSGRLSIRNINFVPVSTKFVCTPNKSNNNIFSHSILDKDLSNGFIFPLNKKLPTDNDKILIAKKVTLVTENKDLRQLEHILGRYGEAEAKLGAWLPPGKNEFLMLIKGDVDFEGAKKVLNETLGSNCINGVVRSFVVDVQLDFNMRYFLGSISYVQQDIGYVLFPACNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSL8</accession>
    <name>Q5CSL8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628049.1">
        <property type="nucleotide sequence ID" value="XM_628049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSL8"/>
    <dbReference type="GeneID" id="3371681"/>
    <dbReference type="KEGG" id="cpv:cgd1_2150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2150"/>
    <dbReference type="InParanoid" id="Q5CSL8"/>
    <dbReference type="OMA" id="RIIYYIY"/>
    <dbReference type="OrthoDB" id="360388at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="1">
        <location>
            <begin position="37"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="689" mass="78803" checksum="ADEEAC62CD3B2241" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSN3</accession>
    <name>Q5CSN3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">COPI associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628034.1">
        <property type="nucleotide sequence ID" value="XM_628034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSN3"/>
    <dbReference type="GeneID" id="3371654"/>
    <dbReference type="KEGG" id="cpv:cgd1_1970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1970"/>
    <dbReference type="InParanoid" id="Q5CSN3"/>
    <dbReference type="OMA" id="YLCNAYQ"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="43"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="73"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="110"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="189" mass="20728" checksum="8A5877F30EA80BE3" modified="2005-04-12" version="1">MVNDYGRQAATTIQNCGNQLLGSGRDYLQNSHIIGEGPKPLRALCFVGGIFLSLASLLGIFSISQLFLSPGSYLFEAVLFGLGIVVMIVESKDIEKLKPFRDFCLEWAKFLTVPAGKGTLYLLSGILAMSIFRINFLELFAGTYMAFLGVICIMVQFGCRNQLQAAGISIDSTGSFSRENTNERFNRLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSX1</accession>
    <name>Q5CSX1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_1010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627946.1">
        <property type="nucleotide sequence ID" value="XM_627946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSX1"/>
    <dbReference type="GeneID" id="3371555"/>
    <dbReference type="KEGG" id="cpv:cgd1_1010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1010"/>
    <dbReference type="InParanoid" id="Q5CSX1"/>
    <dbReference type="OMA" id="CFFTEIC"/>
    <dbReference type="OrthoDB" id="341565at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="231" mass="25844" checksum="81C5C03C2C300ECB" modified="2005-04-12" version="1">MNDLDDSTFRFYTSPEDRNELVNYRSSLSKFDHDEFMLQSTARQSGYVVNSYIHGRAASEYSCSSGSFRDLNSSAEQTTFERSLSPVNRTLDTTTSEVSTIPSARSIVECNRRGRSPSLSYTVTTLQAQRGANQAFKGLTNTNNNIGWNNNQLISSNDRNPLCTLTMKSIDLNPPCLSEDNLSTTRVINNGMLTGSVKNKNYTDKTARSSLCTFFDFCNCFGPRVKDIHNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT63</accession>
    <name>Q5CT63_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Secreted insulinase-like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_4270</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626606.1">
        <property type="nucleotide sequence ID" value="XM_626606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT63"/>
    <dbReference type="SMR" id="Q5CT63"/>
    <dbReference type="FunCoup" id="Q5CT63">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT63"/>
    <dbReference type="GeneID" id="3373689"/>
    <dbReference type="KEGG" id="cpv:cgd2_4270"/>
    <dbReference type="InParanoid" id="Q5CT63"/>
    <dbReference type="OMA" id="QDGYVAF"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="20"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="105"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="267"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="11">
        <location>
            <begin position="574"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="12">
        <location>
            <begin position="949"/>
            <end position="1026"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="355"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1220"/>
            <end position="1257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1220"/>
            <end position="1245"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1257" mass="141065" checksum="506F0CFC2FFFF51D" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT66</accession>
    <name>Q5CT66_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">P-type ATpase3 cation transport ATpase, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd2_4240</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626603.1">
        <property type="nucleotide sequence ID" value="XM_626603.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT66"/>
    <dbReference type="GeneID" id="3373480"/>
    <dbReference type="KEGG" id="cpv:cgd2_4240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4240"/>
    <dbReference type="InParanoid" id="Q5CT66"/>
    <dbReference type="OMA" id="MPEWGYL"/>
    <dbReference type="OrthoDB" id="289856at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF11">
        <property type="entry name" value="CATION-TRANSPORTING P-TYPE ATPASE N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-1278">Translocase</keyword>
    <keyword evidence="2 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="517"/>
            <end position="536"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1255"/>
            <end position="1277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1298"/>
            <end position="1316"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1354"/>
            <end position="1372"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1384"/>
            <end position="1403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1456"/>
            <end position="1474"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="11">
        <location>
            <begin position="331"/>
            <end position="392"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1488" mass="169680" checksum="85856B3E76918449" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTI7</accession>
    <name>Q5CTI7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pleckstrin homology (PH) domain containing protein with N-terminal ankyrin repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_2840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88905.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626482.1">
        <property type="nucleotide sequence ID" value="XM_626482.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTI7"/>
    <dbReference type="GeneID" id="3373702"/>
    <dbReference type="KEGG" id="cpv:cgd2_2840"/>
    <dbReference type="InParanoid" id="Q5CTI7"/>
    <dbReference type="OMA" id="HAAMEQN"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="993"/>
            <end position="1102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="29"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="128"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88905.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1110" mass="127196" checksum="6FD0FBE9B2AAB77E" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTL6</accession>
    <name>Q5CTL6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_2510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626453.1">
        <property type="nucleotide sequence ID" value="XM_626453.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTL6"/>
    <dbReference type="STRING" id="353152.Q5CTL6"/>
    <dbReference type="GeneID" id="3373648"/>
    <dbReference type="KEGG" id="cpv:cgd2_2510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2510"/>
    <dbReference type="InParanoid" id="Q5CTL6"/>
    <dbReference type="OMA" id="IMTYCAR"/>
    <dbReference type="OrthoDB" id="269227at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050660">
        <property type="term" value="F:flavin adenine dinucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016614">
        <property type="term" value="F:oxidoreductase activity, acting on CH-OH group of donors"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051871">
        <property type="entry name" value="GMC_Oxidoreductase-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000172">
        <property type="entry name" value="GMC_OxRdtase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007867">
        <property type="entry name" value="GMC_OxRtase_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45968:SF3">
        <property type="entry name" value="OS04G0573100 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45968">
        <property type="entry name" value="OSJNBA0019K04.7 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05199">
        <property type="entry name" value="GMC_oxred_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00732">
        <property type="entry name" value="GMC_oxred_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00624">
        <property type="entry name" value="GMC_OXRED_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253834" description="Glucose-methanol-choline oxidoreductase N-terminal domain-containing protein" evidence="2">
        <location>
            <begin position="26"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="domain" description="Glucose-methanol-choline oxidoreductase N-terminal" evidence="3">
        <location>
            <begin position="375"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS00624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="764" mass="85173" checksum="85D0FAB8DA1B709A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTL8</accession>
    <name>Q5CTL8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_2490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626451.1">
        <property type="nucleotide sequence ID" value="XM_626451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTL8"/>
    <dbReference type="STRING" id="353152.Q5CTL8"/>
    <dbReference type="GeneID" id="3373495"/>
    <dbReference type="KEGG" id="cpv:cgd2_2490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2490"/>
    <dbReference type="InParanoid" id="Q5CTL8"/>
    <dbReference type="OMA" id="VIYESKQ"/>
    <dbReference type="OrthoDB" id="337043at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.10">
        <property type="entry name" value="Gamma-glutamyl cyclotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="270"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="294" mass="34260" checksum="8D35A8804043136B" modified="2005-04-12" version="1">MTFLFIYDHLMDPFEFKQCFPNVEFRLFGIGRLDNFKINWIAKGLPFCCRTRPTLTPSLNTATYGVIIEINSYEKKMIRKYVKYLPNNLLIETNAVIIKLNFENSGKNSQKNMLFSNSGIRESKNQSSFDLKVMTFFTETSNMIFDSTFTDFLLEKQDDFSNYTYLTELSKSSKKISPALPSENYINLITKVAKFYRLPEVYIEENLNLSSKQRLSVFESLVRKIALKYIYLITKFQIQGIGVGIIDLLWELDPKDPLVFADYGKINKGIVFLIATFIIMLLSPILCFITFFWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTR6</accession>
    <name>Q5CTR6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mif2/CENP-C cupin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88794.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626403.1">
        <property type="nucleotide sequence ID" value="XM_626403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTR6"/>
    <dbReference type="GeneID" id="3373735"/>
    <dbReference type="KEGG" id="cpv:cgd2_1930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1930"/>
    <dbReference type="InParanoid" id="Q5CTR6"/>
    <dbReference type="OMA" id="ILSCKAN"/>
    <dbReference type="OrthoDB" id="341022at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd02208">
        <property type="entry name" value="cupin_RmlC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.10">
        <property type="entry name" value="Jelly Rolls"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014710">
        <property type="entry name" value="RmlC-like_jellyroll"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011051">
        <property type="entry name" value="RmlC_Cupin_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51182">
        <property type="entry name" value="RmlC-like cupins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88794.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="165" mass="18465" checksum="1CAF6D3D25D1DE87" modified="2005-04-12" version="1">MRKKKSSSHLNNENSIVENIERLPSLGKVPEHEGAILMSSEISKSMKRSSSQITDELAISSLLSNAKFTLSVIKIGGNTKTKYEKNTHGFIVVHILSCKADSLIYSLDNKYEFVMSNGSYVHIPPNHFFSFKNLSNESAKISFVVLPKRIREVGSEPAFHRPIVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTR8</accession>
    <name>Q5CTR8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative phosphatidylinositol-4-phosphate 5-kinase, MORN beta hairpin repeats glycine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_1910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626401.1">
        <property type="nucleotide sequence ID" value="XM_626401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTR8"/>
    <dbReference type="STRING" id="353152.Q5CTR8"/>
    <dbReference type="GeneID" id="3373731"/>
    <dbReference type="KEGG" id="cpv:cgd2_1910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1910"/>
    <dbReference type="InParanoid" id="Q5CTR8"/>
    <dbReference type="OMA" id="PRLEIKA"/>
    <dbReference type="OrthoDB" id="282259at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084:SF179">
        <property type="entry name" value="OS10G0565000 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23084">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="347"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="534" mass="60446" checksum="B11B7C1038BAA1FA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTX0</accession>
    <name>Q5CTX0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein with 2 EFh</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_1240</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626349.1">
        <property type="nucleotide sequence ID" value="XM_626349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTX0"/>
    <dbReference type="STRING" id="353152.Q5CTX0"/>
    <dbReference type="GeneID" id="3373683"/>
    <dbReference type="KEGG" id="cpv:cgd2_1240"/>
    <dbReference type="InParanoid" id="Q5CTX0"/>
    <dbReference type="OMA" id="SEELTCY"/>
    <dbReference type="OrthoDB" id="524326at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006897">
        <property type="term" value="P:endocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000261">
        <property type="entry name" value="EH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11216">
        <property type="entry name" value="EH DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12763">
        <property type="entry name" value="EH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50031">
        <property type="entry name" value="EH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EH" evidence="3">
        <location>
            <begin position="66"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="72"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="195"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="433" mass="50523" checksum="2F0E8F8F710FC2A8" modified="2005-04-12" version="1" fragment="single">KLIIFRLDMDLSIKNENSLANFTSEELTCYETWYKIIQHFSDKYPSSSEPINHHDIPKFGMITARFLKTSGIPKDVLHDIWQIVDTENKGILGFSDFGNACRLVSFFQHEKIFPNQHMLSKIPLKLAYFNISKFWEEAEKAVKVDEQDINSIINSYFSDTSHISDCLKRFKDLDEKKSGYLDGITIFNKYISSNLVRKELKQIWDFSDLDEDGKLSAAEFIIFNTLVKVSIERNISINSGVSKQSMLIVINKIIEMESEYKGTDYRNILKLRENNLIQFTPAEEKEVEKLKSEIEMLNGEIDDFKQAKNILTRYKESDDQQILKLSEKKLMLMSEHKELIQNLNEKHSEIVKNRDLINYLYQDIKFLKETNNLLSNFDLPKAINVRNGKVGPDTSINKNIPKINTNIGDVVFEKCQNRRYKDWVEFPSRGNHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTZ7</accession>
    <name>Q5CTZ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative T complex chaperonin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626322.1">
        <property type="nucleotide sequence ID" value="XM_626322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTZ7"/>
    <dbReference type="FunCoup" id="Q5CTZ7">
        <property type="interactions" value="460"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTZ7"/>
    <dbReference type="GeneID" id="3373650"/>
    <dbReference type="KEGG" id="cpv:cgd2_900"/>
    <dbReference type="InParanoid" id="Q5CTZ7"/>
    <dbReference type="OMA" id="WGLKYAV"/>
    <dbReference type="OrthoDB" id="1748577at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03341">
        <property type="entry name" value="TCP1_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000008">
        <property type="entry name" value="T-complex protein 1 subunit theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012721">
        <property type="entry name" value="Chap_CCT_theta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02346">
        <property type="entry name" value="chap_CCT_theta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="564" mass="60980" checksum="367CA8F1E93B7CBC" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU35</accession>
    <name>Q5CU35_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Very low complexity large protein, possible unreal ORF</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626284.1">
        <property type="nucleotide sequence ID" value="XM_626284.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU35"/>
    <dbReference type="GeneID" id="3373686"/>
    <dbReference type="KEGG" id="cpv:cgd2_470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_470"/>
    <dbReference type="InParanoid" id="Q5CU35"/>
    <dbReference type="OrthoDB" id="343728at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="821"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="922"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1101"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1333"/>
            <end position="1359"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="835"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="926"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="980"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1017"/>
            <end position="1031"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1048"/>
            <end position="1057"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1115"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1129"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1142"/>
            <end position="1180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1190"/>
            <end position="1199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1336"/>
            <end position="1359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1359" mass="163893" checksum="B6E2A9CA4A191F5B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU40</accession>
    <name>Q5CU40_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">RNA polymerase Rpb4/RPC9 core domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_4320</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic RPB4 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626974.1">
        <property type="nucleotide sequence ID" value="XM_626974.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU40"/>
    <dbReference type="FunCoup" id="Q5CU40">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU40"/>
    <dbReference type="GeneID" id="3374061"/>
    <dbReference type="KEGG" id="cpv:cgd3_4320"/>
    <dbReference type="InParanoid" id="Q5CU40"/>
    <dbReference type="OMA" id="YQCNFIL"/>
    <dbReference type="OrthoDB" id="2186918at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030880">
        <property type="term" value="C:RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006590">
        <property type="entry name" value="RNA_pol_Rpb4/RPC9_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045222">
        <property type="entry name" value="Rpb4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005574">
        <property type="entry name" value="Rpb4/RPC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038324">
        <property type="entry name" value="Rpb4/RPC9_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21297">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03874">
        <property type="entry name" value="RNA_pol_Rpb4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00657">
        <property type="entry name" value="RPOL4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNA polymerase Rpb4/RPC9 core" evidence="4">
        <location>
            <begin position="19"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025724"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="124" mass="14393" checksum="A353DED1B78EC59A" modified="2005-04-12" version="1" fragment="single">IIYQCNFILLSYELILTQNLELNGIKCLNLSELRLLLEDRMRTYPSGSDEAHTLIKSAYDYSYKFGKIKNRASVILIREALDETTKLHEFEIASLVNLLPRTPDEAKVSMKHPSLYENLIFLRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU46</accession>
    <name>Q5CU46_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Secreted insulinase like peptidase, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_4250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626968.1">
        <property type="nucleotide sequence ID" value="XM_626968.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU46"/>
    <dbReference type="STRING" id="353152.Q5CU46"/>
    <dbReference type="GeneID" id="3373885"/>
    <dbReference type="KEGG" id="cpv:cgd3_4250"/>
    <dbReference type="InParanoid" id="Q5CU46"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254240" evidence="7">
        <location>
            <begin position="26"/>
            <end position="1198"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="93"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="253"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1198" mass="138880" checksum="BA7ECBC67177FECF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU52</accession>
    <name>Q5CU52_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted insulinase like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_4190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88948.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626962.1">
        <property type="nucleotide sequence ID" value="XM_626962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU52"/>
    <dbReference type="GeneID" id="3373886"/>
    <dbReference type="KEGG" id="cpv:cgd3_4190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4190"/>
    <dbReference type="InParanoid" id="Q5CU52"/>
    <dbReference type="OrthoDB" id="343870at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254967" evidence="1">
        <location>
            <begin position="24"/>
            <end position="1085"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88948.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1085" mass="123467" checksum="F253B8212F4DA55E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUA9</accession>
    <name>Q5CUA9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_3550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626905.1">
        <property type="nucleotide sequence ID" value="XM_626905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUA9"/>
    <dbReference type="STRING" id="353152.Q5CUA9"/>
    <dbReference type="GeneID" id="3373863"/>
    <dbReference type="KEGG" id="cpv:cgd3_3550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3550"/>
    <dbReference type="InParanoid" id="Q5CUA9"/>
    <dbReference type="OMA" id="NTNCYLI"/>
    <dbReference type="OrthoDB" id="343643at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37156">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37156:SF2">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253858" evidence="2">
        <location>
            <begin position="25"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="157"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1115" mass="118667" checksum="A8F8CC7A7F426EF8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUE1</accession>
    <name>Q5CUE1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Possible relation to actin related protein 2/3 (Arp2/3) complex subunit 4</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_3220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARPC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89016.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626873.1">
        <property type="nucleotide sequence ID" value="XM_626873.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUE1"/>
    <dbReference type="STRING" id="353152.Q5CUE1"/>
    <dbReference type="GeneID" id="3373876"/>
    <dbReference type="KEGG" id="cpv:cgd3_3220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3220"/>
    <dbReference type="InParanoid" id="Q5CUE1"/>
    <dbReference type="OMA" id="KEYCLIE"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030041">
        <property type="term" value="P:actin filament polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1460.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034666">
        <property type="entry name" value="ARPC2/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008384">
        <property type="entry name" value="ARPC4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629:SF0">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22629">
        <property type="entry name" value="ARP2/3 COMPLEX 20 KD SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05856">
        <property type="entry name" value="ARPC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69645">
        <property type="entry name" value="Arp2/3 complex subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89016.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="313" mass="36746" checksum="38A343CC2C92D042" modified="2005-04-12" version="1">MQSKKIELHDTDSNAPLLPYLRRLFNTLNREICLFYLPLNLPCMYSVPFIEQEHLIKNLSSADNIDISSSKKSFNRNNKVELIKSLYVYRHSKEFCYIESCIDSVRVSLKFYFKCEFERRLFNQLTIFMKKNSDYLQLVRKKSIEGFDISFLITNHILNSYNNKICISNKSNYDGQMGKYDVIHFILKFVVDIDRQIQDKMLQSTYFSRYYIRKLLQEFNVNVLYKQNSINIPKHKKQLDETNKSEIKGIDPNKAEISISEKNNNLLETKKSLTSTKNINSGSIATQLNDSIGRDAIVLKALKTRNRIKNLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUE3</accession>
    <name>Q5CUE3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ser/Thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_3180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626871.1">
        <property type="nucleotide sequence ID" value="XM_626871.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUE3"/>
    <dbReference type="STRING" id="353152.Q5CUE3"/>
    <dbReference type="GeneID" id="3373878"/>
    <dbReference type="KEGG" id="cpv:cgd3_3180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3180"/>
    <dbReference type="InParanoid" id="Q5CUE3"/>
    <dbReference type="OrthoDB" id="338859at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="329"/>
            <end position="661"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="675" mass="75709" checksum="1CE7AC4CC03D2972" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUJ8</accession>
    <name>Q5CUJ8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed RNA polymerase I subunit RPA12</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_2550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626816.1">
        <property type="nucleotide sequence ID" value="XM_626816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUJ8"/>
    <dbReference type="STRING" id="353152.Q5CUJ8"/>
    <dbReference type="GeneID" id="3373778"/>
    <dbReference type="KEGG" id="cpv:cgd3_2550"/>
    <dbReference type="InParanoid" id="Q5CUJ8"/>
    <dbReference type="OMA" id="SHNEAFF"/>
    <dbReference type="OrthoDB" id="282152at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd10507">
        <property type="entry name" value="Zn-ribbon_RPA12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012164">
        <property type="entry name" value="Rpa12/Rpb9/Rpc10/TFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034004">
        <property type="entry name" value="Zn_ribbon_RPA12_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11239:SF12">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS-type" evidence="6">
        <location>
            <begin position="160"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00018784"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="203" mass="23431" checksum="5AB6482D40E9F94E" modified="2005-04-12" version="1" fragment="single">IDVDINTTKQRNSNFPKFQFSFSKGDNFNSQLYGGCPSCGNSYDFLFLLDAFENEYTSSSHNLIENHYLRCKICNYRFLKLHNHNSSDSTINTNSNSFEKKRIYITGIRKSLCFGTNNKWWAKSISVGKRIEKESDNKSGKSNSVIRVLDAMHKKKAPKIQEICPECSHNEAFFTQFQARSADEGTTVMYECCKCQHRRVINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUP0</accession>
    <name>Q5CUP0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative prolyl 4-hydroxylase alpha subunit homolog, 2-oxoglutarate-dependent dioxygenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_2050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626774.1">
        <property type="nucleotide sequence ID" value="XM_626774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUP0"/>
    <dbReference type="STRING" id="353152.Q5CUP0"/>
    <dbReference type="GeneID" id="3374046"/>
    <dbReference type="KEGG" id="cpv:cgd3_2050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2050"/>
    <dbReference type="InParanoid" id="Q5CUP0"/>
    <dbReference type="OMA" id="GHFMPHV"/>
    <dbReference type="OrthoDB" id="69177at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044862">
        <property type="entry name" value="Pro_4_hyd_alph_FE2OG_OXY"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13640">
        <property type="entry name" value="2OG-FeII_Oxy_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 7" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="6">
        <location>
            <begin position="48"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="313" mass="36326" checksum="F460431E06012694" modified="2005-04-12" version="1">MGNYSKYLSIVKEKDMVDEEKVIASFVHEKDPSVDTKNITRQKVPGFPYAEIWDNVFSEDECKEMIASLEKSGEFSFWNPGHSSKKSYRNVDTIEGNMYLLSKFIWERIKNIFNYHEFEINENDSYSEEDNIGKWKSIGIYEKMFFGRYRDGGHFGPHTDCSVCIDTNTRTLWTVLVYLNTIPEEGGGATSFVDESQKTQKRFIDESGRERTNPNNVITRVQPRAGRIVTFFIADMHEGEPLCAGYTKYILRTDILYRRVNPILTSEADQRAYILWLKGKDLTYRGKMDEANEIFKQVSEISPELATKFNCLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUP5</accession>
    <name>Q5CUP5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Hpc2-related domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626769.1">
        <property type="nucleotide sequence ID" value="XM_626769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUP5"/>
    <dbReference type="GeneID" id="3374048"/>
    <dbReference type="KEGG" id="cpv:cgd3_1990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1990"/>
    <dbReference type="InParanoid" id="Q5CUP5"/>
    <dbReference type="OMA" id="CSHEESH"/>
    <dbReference type="OrthoDB" id="341523at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014840">
        <property type="entry name" value="HRD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08729">
        <property type="entry name" value="HUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Hpc2-related" evidence="2">
        <location>
            <begin position="226"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="383"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="632"/>
            <end position="656"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="844"/>
            <end position="904"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="35"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="141"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="633"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="862"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1031" mass="117111" checksum="0DBA3654785F9EA2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUQ7</accession>
    <name>Q5CUQ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">Extracellular protein with a signal peptide and 9 EGF domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd3_1860</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89110.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626757.1">
        <property type="nucleotide sequence ID" value="XM_626757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUQ7"/>
    <dbReference type="STRING" id="353152.Q5CUQ7"/>
    <dbReference type="GeneID" id="3374153"/>
    <dbReference type="KEGG" id="cpv:cgd3_1860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1860"/>
    <dbReference type="InParanoid" id="Q5CUQ7"/>
    <dbReference type="OMA" id="GCENINE"/>
    <dbReference type="OrthoDB" id="5981079at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000014">
        <property type="entry name" value="Latent-transforming growth factor beta-binding protein 3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000009">
        <property type="entry name" value="Low-density lipoprotein receptor isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF205">
        <property type="entry name" value="NIDOGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01186">
        <property type="entry name" value="EGF_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 13" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="12" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0675">Receptor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0964">Secreted</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="218"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="302"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="14">
        <location>
            <begin position="346"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK89110.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="568" mass="62834" checksum="4A7271E4CC57D4FF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUR3</accession>
    <name>Q5CUR3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Importin N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd3_1790</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPO2/CSE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89116.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626751.1">
        <property type="nucleotide sequence ID" value="XM_626751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUR3"/>
    <dbReference type="SMR" id="Q5CUR3"/>
    <dbReference type="FunCoup" id="Q5CUR3">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUR3"/>
    <dbReference type="GeneID" id="3374159"/>
    <dbReference type="KEGG" id="cpv:cgd3_1790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1790"/>
    <dbReference type="InParanoid" id="Q5CUR3"/>
    <dbReference type="OMA" id="AENEFLM"/>
    <dbReference type="OrthoDB" id="3268246at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005043">
        <property type="entry name" value="XPO2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013713">
        <property type="entry name" value="XPO2_central"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997:SF8">
        <property type="entry name" value="EXPORTIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10997">
        <property type="entry name" value="IMPORTIN-7, 8, 11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03378">
        <property type="entry name" value="CAS_CSE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08506">
        <property type="entry name" value="Cse1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="8">
        <location>
            <begin position="22"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89116.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1124" mass="127428" checksum="7CCFD57BC91E8567" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUS8</accession>
    <name>Q5CUS8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_1630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UPF0587 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626736.1">
        <property type="nucleotide sequence ID" value="XM_626736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUS8"/>
    <dbReference type="FunCoup" id="Q5CUS8">
        <property type="interactions" value="252"/>
    </dbReference>
    <dbReference type="GeneID" id="3373831"/>
    <dbReference type="KEGG" id="cpv:cgd3_1630"/>
    <dbReference type="InParanoid" id="Q5CUS8"/>
    <dbReference type="OMA" id="NWCDYNQ"/>
    <dbReference type="OrthoDB" id="10248838at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008584">
        <property type="entry name" value="CXXC_Zn-binding_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12857:SF0">
        <property type="entry name" value="CXXC MOTIF CONTAINING ZINC BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05907">
        <property type="entry name" value="CXXC_Zn-b_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141678">
        <property type="entry name" value="MAL13P1.257-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="186" mass="21432" checksum="824F8D57EF7E8960" modified="2005-04-12" version="1" fragment="single">LLVLNPLGSNNNISLFKFQKLYIEMTVFVLYVQADFEGIEELIFPENYTWCFDIEQSAGSLTKERITVDPNESIEMENSRGIVNFAMKWESDKRQSTITCIKLNNISRMKVTSEDEGKLVPVAAFDCRGINLTKWNPSFGYNVISNSGKKFENINLEELEWCDFDENSNESVGIYNLNSEFRVHKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUT2</accession>
    <name>Q5CUT2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd3_1590</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13 7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626732.1">
        <property type="nucleotide sequence ID" value="XM_626732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUT2"/>
    <dbReference type="STRING" id="353152.Q5CUT2"/>
    <dbReference type="GeneID" id="3373832"/>
    <dbReference type="KEGG" id="cpv:cgd3_1590"/>
    <dbReference type="InParanoid" id="Q5CUT2"/>
    <dbReference type="OMA" id="AYKEHEC"/>
    <dbReference type="OrthoDB" id="7396459at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17960">
        <property type="entry name" value="DEADc_DDX55"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="60"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="317"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="621"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="721"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="640"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="727"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="741"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="752"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="763"/>
            <end position="776"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="792" mass="91571" checksum="0C69CE11B1FD380F" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUW4</accession>
    <name>Q5CUW4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_1240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626700.1">
        <property type="nucleotide sequence ID" value="XM_626700.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUW4"/>
    <dbReference type="GeneID" id="3373990"/>
    <dbReference type="KEGG" id="cpv:cgd3_1240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1240"/>
    <dbReference type="InParanoid" id="Q5CUW4"/>
    <dbReference type="OMA" id="HINIRNT"/>
    <dbReference type="OrthoDB" id="342342at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="456" mass="52607" checksum="F8CB6DCD5C40C036" modified="2005-04-12" version="1">MKEDSNHGLLLDVPFTSPICTINSTDDKILVGTWDGYFYQICLNKKDDVVTVQIEPSYPIRYISALKDSNCEVDPHTGAQKSYELILGGTYRTKVRMKNRINSPITPLEELEISSDSHYQIIETRSSLEPFESHTKGIEFGNKYHGGPLFLFSSTINSYFGFNSEKGEIEILIGNFNLPDREFVILDYDFLNNHLLIVERSPERLDYYALCSLQILELPNSQNYLQEEVDSSNITNLAEIPPKYILNFPIKNPLFITSNIKSDLTLNSSAEYNNFKDSTHVYKYLYSTMFSISDFKKRPLNIFKSMYNLCDAKFWGFNSFIFLVSNHTIIAIDVLFSKDNEFVTNTNTKCKFCIKSPDRNITSISTTNYNYLVALTEKNRIFLLNRNGEIVYSISNITPNKSNFRWVWPAHVFVTHTGTIIFSTTKGLYYIHCDLLDKRKTQFTKNQSFIIDLPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUX3</accession>
    <name>Q5CUX3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89165.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626691.1">
        <property type="nucleotide sequence ID" value="XM_626691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUX3"/>
    <dbReference type="GeneID" id="3374169"/>
    <dbReference type="KEGG" id="cpv:cgd3_1130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1130"/>
    <dbReference type="InParanoid" id="Q5CUX3"/>
    <dbReference type="OrthoDB" id="342535at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="84"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89165.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="228" mass="26397" checksum="5B47742BF6D6DD7E" modified="2005-04-12" version="1">MAFNIFVEYLYILVIFKVNYVISIRNNKSSNKNPTSILNKLGEYSVDLKIIELQKKVDLCSSTLSKTNNELISARLRIAGKQSNSQEIDNNKSEEEIIDELTKKIQEINQECNSFVDLLLLKRIYRFSQITLDENINTEIQVKEEINNVIRNLVITENNAPFIRSLINKAKCNNFSINEHCKLLTSKLLYYMAITPKEIIENFENVQLVDTELAQNCTIQKINNENQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV20</accession>
    <name>Q5CV20_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626644.1">
        <property type="nucleotide sequence ID" value="XM_626644.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV20"/>
    <dbReference type="FunCoup" id="Q5CV20">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV20"/>
    <dbReference type="ESTHER" id="crypv-q5cv20">
        <property type="family name" value="Duf_900"/>
    </dbReference>
    <dbReference type="GeneID" id="3373791"/>
    <dbReference type="KEGG" id="cpv:cgd3_590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_590"/>
    <dbReference type="InParanoid" id="Q5CV20"/>
    <dbReference type="OMA" id="QIHIMAH"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010297">
        <property type="entry name" value="DUF900_hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36513">
        <property type="entry name" value="ABC TRANSMEMBRANE TYPE-1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36513:SF1">
        <property type="entry name" value="TRANSMEMBRANE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05990">
        <property type="entry name" value="DUF900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="63"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="104"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="134"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="247"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1019"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1027"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1089"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1173" mass="134073" checksum="DAE1FCBB7987257B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV95</accession>
    <name>Q5CV95_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD repeats containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_4920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89621.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627374.1">
        <property type="nucleotide sequence ID" value="XM_627374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV95"/>
    <dbReference type="STRING" id="353152.Q5CV95"/>
    <dbReference type="GeneID" id="3374377"/>
    <dbReference type="KEGG" id="cpv:cgd8_4920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4920"/>
    <dbReference type="InParanoid" id="Q5CV95"/>
    <dbReference type="OMA" id="DNIETRT"/>
    <dbReference type="OrthoDB" id="7668193at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF1">
        <property type="entry name" value="GUANINE NUCLEOTIDE-BINDING PROTEIN SUBUNIT BETA-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="279"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89621.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="312" mass="35964" checksum="C7CFC7A8F45A4C71" modified="2005-04-12" version="1">MKSKGKGLISEENEEVPVILLRKLTKNETILSLEFIKDDSHLISGNISGVLDIWDLEIMRCSSSINMKFDSPIIKTIYDEKKEIIYVQNRKGEIYLVDNTENFKKLDLNGIYYSLAKMIILPTRESIIFPRENDLLLKNINNSKHDDIQFNYPTEKSDKLIEVESLNDHSVLLGFESGNVVIWDLRKPDSHVYMNNVTQNSPILSMKRSFNRIWISTFDSKLRVFNRNCFDHPIKEIDSLNVVDKISIRSDSLITVTSNTLNTNMDIFENKSLNYIKTFKFHSTEVSSIQFSNSSNLFAASSNTISIWDLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVB4</accession>
    <name>Q5CVB4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627355.1">
        <property type="nucleotide sequence ID" value="XM_627355.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVB4"/>
    <dbReference type="GeneID" id="3374453"/>
    <dbReference type="KEGG" id="cpv:cgd8_4710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4710"/>
    <dbReference type="InParanoid" id="Q5CVB4"/>
    <dbReference type="OrthoDB" id="343171at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="571"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="347"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="438"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="585"/>
            <end position="605"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="605" mass="72218" checksum="B1534139D281D20C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVE2</accession>
    <name>Q5CVE2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627327.1">
        <property type="nucleotide sequence ID" value="XM_627327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVE2"/>
    <dbReference type="GeneID" id="3374532"/>
    <dbReference type="KEGG" id="cpv:cgd8_4390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4390"/>
    <dbReference type="InParanoid" id="Q5CVE2"/>
    <dbReference type="OMA" id="DYFAAWI"/>
    <dbReference type="OrthoDB" id="342576at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="137"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="177" mass="19289" checksum="1D98C83328F4A398" modified="2005-04-12" version="1">MSYAETLKNQSESLLSSAQQGIDKAREYADYEKASGFLFPHPLGKVGPLPLRRVVTILSSVTLAFSIFQIFTAMSFPGLIVAIARFGVGVIGLIAAYQKQESTSKMFAYAQALLLTISSLLLVSAIFFAIIRLGFSVFSFVVLIISIITVGFDYFAAWVASSYYEALRRGVSVESQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVF0</accession>
    <name>Q5CVF0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_4300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627319.1">
        <property type="nucleotide sequence ID" value="XM_627319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVF0"/>
    <dbReference type="GeneID" id="3374551"/>
    <dbReference type="KEGG" id="cpv:cgd8_4300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4300"/>
    <dbReference type="InParanoid" id="Q5CVF0"/>
    <dbReference type="OrthoDB" id="361676at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="177" mass="19660" checksum="E86C06CB061A6AF9" modified="2005-04-12" version="1">MVKLSNLKKAILLLGCIGMSNALTVFHLTNPFDLLQGLSHVKLERTTELPVSHKTLRFLQEKIKSFSVDGDNVAKEAIQGISSTTGVNFKTTPLSQEAFKLQSNTLFAEAAEKRKVAKYLQEQSGMTETELTQAEIDPKKNPEKAAAITNMKRAKVLLAQAYILEGKVLYLNKKLIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVM4</accession>
    <name>Q5CVM4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted protein with cysteine rich repeats and a mucin like threonine rich repeat, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627245.1">
        <property type="nucleotide sequence ID" value="XM_627245.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVM4"/>
    <dbReference type="STRING" id="353152.Q5CVM4"/>
    <dbReference type="GeneID" id="3374289"/>
    <dbReference type="KEGG" id="cpv:cgd8_3520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3520"/>
    <dbReference type="InParanoid" id="Q5CVM4"/>
    <dbReference type="OMA" id="NIMEERA"/>
    <dbReference type="OrthoDB" id="343442at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053121">
        <property type="entry name" value="Spore_Coat_Assembly"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35365">
        <property type="entry name" value="LP04239P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR35365:SF18">
        <property type="entry name" value="MUCIN-19-LIKE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254282" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="443"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="881"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1104"/>
            <end position="1124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="477"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="881"/>
            <end position="1020"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1041"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1069"/>
            <end position="1080"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1124" mass="120833" checksum="E3EB73E8DC34C87E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVM6</accession>
    <name>Q5CVM6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_3500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627243.1">
        <property type="nucleotide sequence ID" value="XM_627243.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3374288"/>
    <dbReference type="KEGG" id="cpv:cgd8_3500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3500"/>
    <dbReference type="InParanoid" id="Q5CVM6"/>
    <dbReference type="OrthoDB" id="344144at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1427" mass="167760" checksum="16B42A4E99A42D55" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVN3</accession>
    <name>Q5CVN3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Zincin/aminopeptidase N like metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd8_3430</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89509.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627236.1">
        <property type="nucleotide sequence ID" value="XM_627236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVN3"/>
    <dbReference type="STRING" id="353152.Q5CVN3"/>
    <dbReference type="MEROPS" id="M01.005"/>
    <dbReference type="GeneID" id="3374302"/>
    <dbReference type="KEGG" id="cpv:cgd8_3430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3430"/>
    <dbReference type="InParanoid" id="Q5CVN3"/>
    <dbReference type="OMA" id="MDRINPR"/>
    <dbReference type="OrthoDB" id="10031169at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09600">
        <property type="entry name" value="M1_APN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2010.30:FF:000002">
        <property type="entry name" value="Putative aminopeptidase N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1840">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2010.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.10">
        <property type="entry name" value="Neutral Protease Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.50.10">
        <property type="entry name" value="Peptidase M1, alanyl aminopeptidase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1730">
        <property type="entry name" value="tricorn interacting facor f3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045357">
        <property type="entry name" value="Aminopeptidase_N-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042097">
        <property type="entry name" value="Aminopeptidase_N-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038438">
        <property type="entry name" value="PepN_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001930">
        <property type="entry name" value="Peptidase_M1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014782">
        <property type="entry name" value="Peptidase_M1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012779">
        <property type="entry name" value="Peptidase_M1_pepN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024601">
        <property type="entry name" value="Peptidase_M1_pepN_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037144">
        <property type="entry name" value="Peptidase_M1_pepN_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035414">
        <property type="entry name" value="Peptidase_M1_pepN_Ig-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027268">
        <property type="entry name" value="Peptidase_M4/M1_CTD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02414">
        <property type="entry name" value="pepN_proteo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46322">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46322:SF1">
        <property type="entry name" value="PUROMYCIN-SENSITIVE AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11940">
        <property type="entry name" value="DUF3458"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17432">
        <property type="entry name" value="DUF3458_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01433">
        <property type="entry name" value="Peptidase_M1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17900">
        <property type="entry name" value="Peptidase_M1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00756">
        <property type="entry name" value="ALADIPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63737">
        <property type="entry name" value="Leukotriene A4 hydrolase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55486">
        <property type="entry name" value="Metalloproteases ('zincins'), catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 13" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 13" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="4 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminopeptidase N-like N-terminal" evidence="12">
        <location>
            <begin position="45"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 membrane alanine aminopeptidase" evidence="9">
        <location>
            <begin position="265"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 alanyl aminopeptidase Ig-like fold" evidence="10">
        <location>
            <begin position="483"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M1 alanyl aminopeptidase C-terminal" evidence="11">
        <location>
            <begin position="584"/>
            <end position="932"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF11940"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF17432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK89509.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="936" mass="105910" checksum="27E2AAB5AB8554C8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVR7</accession>
    <name>Q5CVR7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted membrane associated protein, transmembrane domain near C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89481.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627202.1">
        <property type="nucleotide sequence ID" value="XM_627202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVR7"/>
    <dbReference type="GeneID" id="3374317"/>
    <dbReference type="KEGG" id="cpv:cgd8_3040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3040"/>
    <dbReference type="InParanoid" id="Q5CVR7"/>
    <dbReference type="OMA" id="PLERWCI"/>
    <dbReference type="OrthoDB" id="343065at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254471" evidence="2">
        <location>
            <begin position="17"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="824"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89481.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="875" mass="101132" checksum="BEDE622E90138FB5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVU5</accession>
    <name>Q5CVU5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627174.1">
        <property type="nucleotide sequence ID" value="XM_627174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVU5"/>
    <dbReference type="GeneID" id="3374388"/>
    <dbReference type="KEGG" id="cpv:cgd8_2740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2740"/>
    <dbReference type="InParanoid" id="Q5CVU5"/>
    <dbReference type="OrthoDB" id="341529at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="222"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="229"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="341" mass="39486" checksum="7E83BB7C84172D18" modified="2005-04-12" version="1">MSCSNNDKTYQEDDYLIILHKDECSNDREFEEAIKLNLGSYYYIYQRTEFIDDSENYHRFPSQILLKRINLLKTYIKTSNLNIPLNLNRLKEMINEFLSLDVDFLQKIGSINKEIENLKIFITSNFENNIKKFGPNIEYKKKIQKSIDFIYWLLKKKTDFHCSESETEEFFNLNKVKSESKVNDGFKGSSQIESEVSFEQKIHDISSNNKIIELAASKKTQDYQGNTSPDKEMNHFDLNDNSSLRSAIGGEQIMNGTENDSSDNSNIDDVDSDISQKSEPIINKNRMHKLYRRAGTVINGNNSSIISDAKLDKDKYLKLIESYKGLTKSTEIKENISANQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVU7</accession>
    <name>Q5CVU7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Insulinase like metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_2720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627172.1">
        <property type="nucleotide sequence ID" value="XM_627172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVU7"/>
    <dbReference type="STRING" id="353152.Q5CVU7"/>
    <dbReference type="GeneID" id="3374386"/>
    <dbReference type="KEGG" id="cpv:cgd8_2720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2720"/>
    <dbReference type="InParanoid" id="Q5CVU7"/>
    <dbReference type="OMA" id="CVEGPFW"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016:SF16">
        <property type="entry name" value="METALLOPROTEASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_4G07610)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43016">
        <property type="entry name" value="PRESEQUENCE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="1">
        <location>
            <begin position="78"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="2">
        <location>
            <begin position="245"/>
            <end position="434"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1201" mass="138472" checksum="80E1434C8A7C328E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW48</accession>
    <name>Q5CW48_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PRA1 family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_1640</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Membrane</location>
            <topology evidence="1 5">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PRA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627071.1">
        <property type="nucleotide sequence ID" value="XM_627071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW48"/>
    <dbReference type="STRING" id="353152.Q5CW48"/>
    <dbReference type="TCDB" id="9.A.49.1.11">
        <property type="family name" value="the prenylated rab acceptor protein 1 (pra1) family"/>
    </dbReference>
    <dbReference type="GeneID" id="3374599"/>
    <dbReference type="KEGG" id="cpv:cgd8_1640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1640"/>
    <dbReference type="InParanoid" id="Q5CW48"/>
    <dbReference type="OMA" id="CIHAASH"/>
    <dbReference type="OrthoDB" id="63113at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004895">
        <property type="entry name" value="Prenylated_rab_accept_PRA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19317:SF0">
        <property type="entry name" value="PRENYLATED RAB ACCEPTOR PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03208">
        <property type="entry name" value="PRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="119"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="172"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="226" mass="24677" checksum="FDECCDB43C41E1F8" modified="2005-04-12" version="1">MYREQSSTVLDSPMNGGSAKLGASSSSSMSSNFTRMDSFNRSGSKTGSIAPKSSEYGPTVQQILETYESLRLKAQGLAKRKLRSWDGDFFCLSSFQKVSQPKEITDRLERNLRYFLLNYIVIILGMTMLSLILNPISLIIILISTFSSAFVASRPTDMVVLPGDNVISKKVALYVIAGTSTVIILVFSGALLFTSLAVSLILVCIHAVIHIGKSNYDQVANLESEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWU0</accession>
    <name>Q5CWU0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="3">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_3750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90157.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627714.1">
        <property type="nucleotide sequence ID" value="XM_627714.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWU0"/>
    <dbReference type="STRING" id="353152.Q5CWU0"/>
    <dbReference type="GeneID" id="3375902"/>
    <dbReference type="KEGG" id="cpv:cgd6_3750"/>
    <dbReference type="InParanoid" id="Q5CWU0"/>
    <dbReference type="OMA" id="DSCWIHS"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037439">
        <property type="entry name" value="Branching_enzy"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF11">
        <property type="entry name" value="MALTO-OLIGOSYLTREHALOSE TREHALOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000463">
        <property type="entry name" value="GlgB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="6">
        <location>
            <begin position="156"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="318"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="5">
        <location>
            <position position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000463-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90157.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="642" mass="75216" checksum="DEDCAB01871C3528" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX52</accession>
    <name>Q5CX52_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Sulfhydryl oxidase</fullName>
            <ecNumber evidence="8">1.8.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_2470</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2 R'C(R)SH + O2 = R'C(R)S-S(R)CR' + H2O2</text>
            <dbReference type="Rhea" id="RHEA:17357"/>
            <dbReference type="ChEBI" id="CHEBI:15379"/>
            <dbReference type="ChEBI" id="CHEBI:16240"/>
            <dbReference type="ChEBI" id="CHEBI:16520"/>
            <dbReference type="ChEBI" id="CHEBI:17412"/>
            <dbReference type="EC" id="1.8.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 8">
            <name>FAD</name>
            <dbReference type="ChEBI" id="CHEBI:57692"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.8.3.2" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89893.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627602.1">
        <property type="nucleotide sequence ID" value="XM_627602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX52"/>
    <dbReference type="STRING" id="353152.Q5CX52"/>
    <dbReference type="GeneID" id="3376133"/>
    <dbReference type="KEGG" id="cpv:cgd6_2470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2470"/>
    <dbReference type="InParanoid" id="Q5CX52"/>
    <dbReference type="OMA" id="YYGFCNI"/>
    <dbReference type="OrthoDB" id="59470at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005615">
        <property type="term" value="C:extracellular space"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016971">
        <property type="term" value="F:flavin-dependent sulfhydryl oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.310">
        <property type="entry name" value="ERV/ALR sulfhydryl oxidase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036774">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxid_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017905">
        <property type="entry name" value="ERV/ALR_sulphydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039798">
        <property type="entry name" value="Sulfhydryl_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897">
        <property type="entry name" value="QUIESCIN Q6-RELATED SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22897:SF8">
        <property type="entry name" value="SULFHYDRYL OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04777">
        <property type="entry name" value="Evr1_Alr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69000">
        <property type="entry name" value="FAD-dependent thiol oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51324">
        <property type="entry name" value="ERV_ALR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 8" id="KW-0274">FAD</keyword>
    <keyword evidence="2 8" id="KW-0285">Flavoprotein</keyword>
    <keyword evidence="7" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 8" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="30"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="624"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="ERV/ALR sulfhydryl oxidase" evidence="9">
        <location>
            <begin position="369"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022827"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU371123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89893.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="655" mass="75263" checksum="7E2AC8A5C9DA5629" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX83</accession>
    <name>Q5CX83_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_2110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627571.1">
        <property type="nucleotide sequence ID" value="XM_627571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX83"/>
    <dbReference type="GeneID" id="3376079"/>
    <dbReference type="KEGG" id="cpv:cgd6_2110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2110"/>
    <dbReference type="InParanoid" id="Q5CX83"/>
    <dbReference type="OrthoDB" id="341241at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="964" mass="111815" checksum="6D55C1EBB156564D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXB6</accession>
    <name>Q5CXB6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_1720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627538.1">
        <property type="nucleotide sequence ID" value="XM_627538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXB6"/>
    <dbReference type="GeneID" id="3376119"/>
    <dbReference type="KEGG" id="cpv:cgd6_1720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1720"/>
    <dbReference type="InParanoid" id="Q5CXB6"/>
    <dbReference type="OMA" id="CEMIRKI"/>
    <dbReference type="OrthoDB" id="339375at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="281" mass="32984" checksum="C8B0744C08D0D19B" modified="2007-04-03" version="1">MLYKMDEECFNVHSPGVFEVRKAGKSFRKSAPAVVRAIPRVNKRYAKPPFSVEQLEKICADYIRPYRQIYRNAVLTYTERKIKSKRKCELFRKVLLNRENLYFNSLKKCVIFDTDWAKEKLKQEENKIISLTNNETKSLIDIYLLRSVANEKTNKQRELLVKLKQFWSEYPEKLNKKIEFERNKVLDMMKLIGESKLKGELVIETTQDISINSSRPNTFTNNDKFSLEQLEQIRLMATGYEVTTGKFSVMINNLTQRIDHILGAEKRLNNVAKALVLNSEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXK3</accession>
    <name>Q5CXK3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-like protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd6_760</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627451.1">
        <property type="nucleotide sequence ID" value="XM_627451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXK3"/>
    <dbReference type="STRING" id="353152.Q5CXK3"/>
    <dbReference type="GeneID" id="3376058"/>
    <dbReference type="KEGG" id="cpv:cgd6_760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_760"/>
    <dbReference type="InParanoid" id="Q5CXK3"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="567"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="638"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="669"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="697"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="727"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="904"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="12">
        <location>
            <begin position="633"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="341"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="49"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="107"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="177"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="217"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="11">
        <location>
            <begin position="345"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="359"/>
            <end position="377"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK89768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="990" mass="109018" checksum="EE178B6FF6526EE0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXL9</accession>
    <name>Q5CXL9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Low complexity protein having signal peptide and glycine-rich repeat at C-terminal region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627435.1">
        <property type="nucleotide sequence ID" value="XM_627435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXL9"/>
    <dbReference type="GeneID" id="3376047"/>
    <dbReference type="KEGG" id="cpv:cgd6_530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_530"/>
    <dbReference type="InParanoid" id="Q5CXL9"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="359"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="360"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="741" mass="81565" checksum="AF7F364821F0B4D2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXM6</accession>
    <name>Q5CXM6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627428.1">
        <property type="nucleotide sequence ID" value="XM_627428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXM6"/>
    <dbReference type="GeneID" id="3376041"/>
    <dbReference type="KEGG" id="cpv:cgd6_450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_450"/>
    <dbReference type="InParanoid" id="Q5CXM6"/>
    <dbReference type="OrthoDB" id="360521at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="360" mass="41342" checksum="CECB6D94F8AC3BD2" modified="2005-04-12" version="1">MIGEIPKGEELLYELNTLNSSSNNNDNNGNQTNGISELLGNYVSSEINLLNNDTYKKIGYGTLIDNDLNIASEKSANINTGFFERFNCHGAKILEFTNSGNNAVFNRQNELDFEYSQNYLQTKQHPSNANSNSQLLDINPVNFFSSSRNKLDVNMKKEEEDNNNNNTRRVKFNFNKTNKNNKNDHDSLFNNPISRNVLLNCTKQIQHEQINQLGLFNKNNLIQKKSNEIDSKNQILFELQNNQSDNNIDQIKEEKPIWMQQIQQEHIQAIELLKYFWGLSLSPKDNDERRKTIESLNKITHNIELLVHDNKNISASSLSTFGQSSNTIRSICLPILETIKSARNFHIKLDEIINSLSINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXS9</accession>
    <name>Q5CXS9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_5080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628651.1">
        <property type="nucleotide sequence ID" value="XM_628649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXS9"/>
    <dbReference type="STRING" id="353152.Q5CXS9"/>
    <dbReference type="GeneID" id="3372084"/>
    <dbReference type="KEGG" id="cpv:cgd7_5080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5080"/>
    <dbReference type="InParanoid" id="Q5CXS9"/>
    <dbReference type="OMA" id="NTCEYEL"/>
    <dbReference type="OrthoDB" id="339613at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5044262341" evidence="2">
        <location>
            <begin position="22"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="568"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="610"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="635"/>
            <end position="654"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="670" mass="76916" checksum="6BDCD218AD557781" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXU6</accession>
    <name>Q5CXU6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiqutin C-terminal hydrolase of the cysteine proteinase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628634.1">
        <property type="nucleotide sequence ID" value="XM_628632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXU6"/>
    <dbReference type="GeneID" id="3372227"/>
    <dbReference type="KEGG" id="cpv:cgd7_4900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4900"/>
    <dbReference type="InParanoid" id="Q5CXU6"/>
    <dbReference type="OMA" id="NCETQAR"/>
    <dbReference type="OrthoDB" id="286820at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF747">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="590"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="910" mass="105580" checksum="91CECD3CB4811A20" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXV0</accession>
    <name>Q5CXV0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_4830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 3">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90449.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628630.1">
        <property type="nucleotide sequence ID" value="XM_628628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXV0"/>
    <dbReference type="FunCoup" id="Q5CXV0">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXV0"/>
    <dbReference type="GeneID" id="3372222"/>
    <dbReference type="KEGG" id="cpv:cgd7_4830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4830"/>
    <dbReference type="InParanoid" id="Q5CXV0"/>
    <dbReference type="OMA" id="WGNWQRI"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="6">
        <location>
            <begin position="749"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="495"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="545"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="935"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="29"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="495"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR017209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90449.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="954" mass="110827" checksum="63B602EF3FA13F7A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXV7</accession>
    <name>Q5CXV7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_4750</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90444.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628623.1">
        <property type="nucleotide sequence ID" value="XM_628621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXV7"/>
    <dbReference type="GeneID" id="3372198"/>
    <dbReference type="KEGG" id="cpv:cgd7_4750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4750"/>
    <dbReference type="InParanoid" id="Q5CXV7"/>
    <dbReference type="OMA" id="TECCYTI"/>
    <dbReference type="OrthoDB" id="336185at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90444.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="246" mass="28510" checksum="665373678DDE1E94" modified="2005-04-12" version="1">MDLTIPEVTTRRRIVLEGYLDFSNSVTSWDIYKNMLRKSSEMFVYCHSKKALICPTPRRRGVKEDGCIIAYNSGYILSIGENEETCTEYISWLRKKFRQHDPSVPLEIKQVNSILRVEMPSKIGLINIFKLYNTIIASNHVFEILFDPELYTAMIISFQPNGIYSNEDTTSANKFLRFPDEQVEEAKNEITQCCFVVSVNYILVHKVKDHAQGLEAVQMLMKYLYRNDLIVAPIDTNVPYSRDIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXX9</accession>
    <name>Q5CXX9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sgnal peptide, large secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628601.1">
        <property type="nucleotide sequence ID" value="XM_628599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXX9"/>
    <dbReference type="STRING" id="353152.Q5CXX9"/>
    <dbReference type="GeneID" id="3372180"/>
    <dbReference type="KEGG" id="cpv:cgd7_4500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4500"/>
    <dbReference type="InParanoid" id="Q5CXX9"/>
    <dbReference type="OMA" id="FMEMIWE"/>
    <dbReference type="OrthoDB" id="343379at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254355" evidence="2">
        <location>
            <begin position="23"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="144"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="206"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="836" mass="91717" checksum="D22A020544CB17EE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXZ8</accession>
    <name>Q5CXZ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide, large secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628582.1">
        <property type="nucleotide sequence ID" value="XM_628580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXZ8"/>
    <dbReference type="STRING" id="353152.Q5CXZ8"/>
    <dbReference type="GeneID" id="3372161"/>
    <dbReference type="KEGG" id="cpv:cgd7_4280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4280"/>
    <dbReference type="InParanoid" id="Q5CXZ8"/>
    <dbReference type="OMA" id="GIMESKM"/>
    <dbReference type="OrthoDB" id="341717at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255078" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1103"/>
            <end position="1113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1113" mass="120693" checksum="326153B31A0E2D15" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY00</accession>
    <name>Q5CY00_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_4260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628580.1">
        <property type="nucleotide sequence ID" value="XM_628578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY00"/>
    <dbReference type="GeneID" id="3372080"/>
    <dbReference type="KEGG" id="cpv:cgd7_4260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4260"/>
    <dbReference type="InParanoid" id="Q5CY00"/>
    <dbReference type="OMA" id="IASMEWK"/>
    <dbReference type="OrthoDB" id="337924at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="606" mass="68838" checksum="0CF0154C0F18C162" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY03</accession>
    <name>Q5CY03_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628577.1">
        <property type="nucleotide sequence ID" value="XM_628575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY03"/>
    <dbReference type="STRING" id="353152.Q5CY03"/>
    <dbReference type="GeneID" id="3372160"/>
    <dbReference type="KEGG" id="cpv:cgd7_4230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4230"/>
    <dbReference type="InParanoid" id="Q5CY03"/>
    <dbReference type="OMA" id="TENIWIC"/>
    <dbReference type="OrthoDB" id="338920at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="610" mass="67166" checksum="238A0AD86C59BEFB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY56</accession>
    <name>Q5CY56_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RPR domain protein (Involved in RNA metabolism)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628524.1">
        <property type="nucleotide sequence ID" value="XM_628522.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY56"/>
    <dbReference type="GeneID" id="3372110"/>
    <dbReference type="KEGG" id="cpv:cgd7_3610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3610"/>
    <dbReference type="InParanoid" id="Q5CY56"/>
    <dbReference type="OMA" id="NLINIEY"/>
    <dbReference type="OrthoDB" id="340651at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00582">
        <property type="entry name" value="RPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48464">
        <property type="entry name" value="ENTH/VHS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51391">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="10"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51391"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="300" mass="34658" checksum="099E7BCD64711D92" modified="2005-04-12" version="1">MPFFTNTGFNTEEFESQLHLFAQKLQTINTQQDVICALSESIICIKENTVILQLYMRVVEEYSSRAPPEHLIPLVYILNDFAQKCKSQAHYTSEALFNIFNQINLYHTEYMAKARRCYNIWKIREIFDNDTLRKLDCALLGLTPPVPSALSCGNLKELQALNSEPYHRANAVNNLTDSSQRNQTNNDTYNEPNYLELQFNTHNEDDLKLESQYLTLCASVDNVLKDAASIREKRKIIQNICSMNRTSKLSSNEKLLKLIEMEWDLRCNICLNLQETLNLLDHLHSEVIIRLSNTVTTLQG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYC4</accession>
    <name>Q5CYC4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SLBP family of RNA binding proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_2890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628456.1">
        <property type="nucleotide sequence ID" value="XM_628454.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYC4"/>
    <dbReference type="STRING" id="353152.Q5CYC4"/>
    <dbReference type="GeneID" id="3371974"/>
    <dbReference type="KEGG" id="cpv:cgd7_2890"/>
    <dbReference type="InParanoid" id="Q5CYC4"/>
    <dbReference type="OMA" id="EKSHDIM"/>
    <dbReference type="OrthoDB" id="265795at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071204">
        <property type="term" value="C:histone pre-mRNA 3'end processing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071207">
        <property type="term" value="F:histone pre-mRNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1120">
        <property type="entry name" value="Histone RNA hairpin-binding protein RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026502">
        <property type="entry name" value="SLBP1/SLBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029344">
        <property type="entry name" value="SLBP_RNA_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038294">
        <property type="entry name" value="SLBP_RNA_bind_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408:SF0">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15247">
        <property type="entry name" value="SLBP_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Histone RNA hairpin-binding protein RNA-binding" evidence="3">
        <location>
            <begin position="21"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="353" mass="41028" checksum="44416F619A38F2A4" modified="2005-04-12" version="1" fragment="single">AALFIIITRSLGIFKLLSKIEERRISQRLKQINIAKNSVGYQRYTTAVRKNERKRELSFTWHPSTPDPYSNTSKSCFSGRLKEWKLRLHLWGNLDDLEYSNLIQNNLKFPPGANSNPFSKVNYFENILDNGNDNTNESSLKFIRFSELRISPISFSGQNSLIKTNRGERISKSDSLVNSIKLSRKILLPKVMDCEKSHDIMKYITLFIPDNYKGMLIWKSTNFIRHCDIILTAHKHRLKILKHGLSLFEFNKRYNIDVSGLAHNSNNFLKDIQISISGIDSNSNKLCKLSDKPYKNICTLISHQKMISHFSKKVVLTQNKLFGFREQDVFKLSFAYHPSSIIYYKILEKLHKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYG4</accession>
    <name>Q5CYG4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Translation initiation factor eIF-5 Tif5p, ZnR+W2 domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_2430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-beta/eIF-5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628416.1">
        <property type="nucleotide sequence ID" value="XM_628414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYG4"/>
    <dbReference type="FunCoup" id="Q5CYG4">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYG4"/>
    <dbReference type="GeneID" id="3372213"/>
    <dbReference type="KEGG" id="cpv:cgd7_2430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2430"/>
    <dbReference type="InParanoid" id="Q5CYG4"/>
    <dbReference type="OMA" id="MLNLKCA"/>
    <dbReference type="OrthoDB" id="10250831at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071074">
        <property type="term" value="F:eukaryotic initiation factor eIF2 binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005092">
        <property type="term" value="F:GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11561">
        <property type="entry name" value="W2_eIF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.350:FF:000001">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.170:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.350">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.30.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045196">
        <property type="entry name" value="IF2/IF5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002735">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016189">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016190">
        <property type="entry name" value="Transl_init_fac_IF2/IF5_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23001:SF7">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01873">
        <property type="entry name" value="eIF-5_eIF-2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02020">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00653">
        <property type="entry name" value="eIF2B_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100966">
        <property type="entry name" value="Translation initiation factor 2 beta, aIF2beta, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75689">
        <property type="entry name" value="Zinc-binding domain of translation initiation factor 2 beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="2 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="7">
        <location>
            <begin position="209"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="136"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="377"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="427"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="157"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="185"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="377"/>
            <end position="401"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="460" mass="52016" checksum="E9C5D4391719D45D" modified="2005-04-12" version="1">MLNIPSTVDDPNYRYKMPKLVSKIEGRGNGIRTKIVNMADIARSLKRPPAYPTKFFGCELGALSKWEDKEEKSIVNGAHQQNDLQRLMDKFIQMYVLCPNCELPEIDIIVKKERVSCKCNACGYIGALDNNHKITTYISKNPPGGVESTMGSKNKKERRERDKDRSSEGCNNSNGSTAADNEKPSKHKSKKASKKSSKKSPHELDIFEKDVLTFESPEIVDVIERLTNFMQKNEEVSPEDFFSELRVLQVSQDFDEFMRFSVLLAVLFGLKDPIDPKVFKLRIPYISKAVEGSLRSNAIISIFESYCVEKNPSTLATYPYLIQQLYDADILSEKVILKYYQKDAPTSWVSGCSTQDTFEKAKKSCEPFVDWLLDGSNDESDLSDENNDDYDTNNSDIDEDDSHSPVRSSRVKVKSLNLSEKLDSYKFESCSGSEDDGSLTKNVENSQSQNSDSDLDIDNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYH5</accession>
    <name>Q5CYH5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Thioesterase of the a/b hydrolase superfamily, possible bacterial origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628405.1">
        <property type="nucleotide sequence ID" value="XM_628403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYH5"/>
    <dbReference type="ESTHER" id="crypi-q5cyh5">
        <property type="family name" value="Thioesterase"/>
    </dbReference>
    <dbReference type="GeneID" id="3372206"/>
    <dbReference type="KEGG" id="cpv:cgd7_2320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2320"/>
    <dbReference type="InParanoid" id="Q5CYH5"/>
    <dbReference type="OMA" id="PCSIFRA"/>
    <dbReference type="OrthoDB" id="541883at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008610">
        <property type="term" value="P:lipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012223">
        <property type="entry name" value="TEII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487:SF0">
        <property type="entry name" value="S-ACYL FATTY ACID SYNTHASE THIOESTERASE, MEDIUM CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11487">
        <property type="entry name" value="THIOESTERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12697">
        <property type="entry name" value="Abhydrolase_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="1">
        <location>
            <begin position="33"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12697"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="339" mass="39618" checksum="BD1949A55FFE79A5" modified="2005-04-12" version="1">MSKSDFDKWFPSYSKVNSHLINLGSRNQPICRLLCIHGAGGSDQIFVKKDLNTGRESSNILLDYAQENGIELLVLQLPGRAGRSHEACYEDIATLINDFYPVFKSHFFGKANLTEYIELIPWVIVGHSMGGLIGFELLKRIKFEQLKDFSAKFGVTDQSGFENKIVKLLREKRIFPELFIIMSSFPPNIPEYDRPWRKNEELNDEEFKQECREWGINQNVFKKGIWEEFEKQLRCDFTMFDSFEMNLVDKIFYCSNQSLYNFMYPLGVDAQLWSASQDSKVTKDIMNKWKELLTSNGNSLDTREIDAQHNFLHDPKARKEWMQDLSTSLDKIILDLEYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYJ8</accession>
    <name>Q5CYJ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hch1p like mystery proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_2050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628382.1">
        <property type="nucleotide sequence ID" value="XM_628380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYJ8"/>
    <dbReference type="STRING" id="353152.Q5CYJ8"/>
    <dbReference type="GeneID" id="3371800"/>
    <dbReference type="KEGG" id="cpv:cgd7_2050"/>
    <dbReference type="InParanoid" id="Q5CYJ8"/>
    <dbReference type="OMA" id="EDNDYEI"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009">
        <property type="entry name" value="HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13009:SF22">
        <property type="entry name" value="LD43819P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="24"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="3">
        <location>
            <begin position="240"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="173"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="389" mass="44950" checksum="5058E13C0AEA0DF3" modified="2005-04-12" version="1" fragment="single">LREAKKMTEISGSLWNANNWHWEEKDYSKWGKEELRTIMESIKYSFELEAPKFELSFSDLSIRGEASISVRKKQPILAYEFSISGTWSVNEVESQKKIILGQITIPEFSVDNYEEDFPIMITCKEVISKDYNSELILSEMKKKVVVKLRKKLMEFHNKLLNKENDQRKIETERVKREEEIKTAEIARVEKEEEKRQIYNQQIEKETLIKQRESEASTKTIDPHPQAQGSVWNANNWHWEEKPETNWVISTLTKMIEDLSTNKSDSGNSDLIPISFSEVKVTGEASSSVRKGKKICVLDCSVFGRFNAIIPEGMLSQNKESNLIGSFSLTEINMMDTHDYGKKINYESAELGLKTADIPEFIDFKGKIEKQILGSLDSAIQKFCVEFLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYU3</accession>
    <name>Q5CYU3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_990</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628287.1">
        <property type="nucleotide sequence ID" value="XM_628285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYU3"/>
    <dbReference type="GeneID" id="3371996"/>
    <dbReference type="KEGG" id="cpv:cgd7_990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_990"/>
    <dbReference type="InParanoid" id="Q5CYU3"/>
    <dbReference type="OrthoDB" id="340498at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="457" mass="52595" checksum="167243A60140CBD9" modified="2005-04-12" version="1">MSRKEHEDDDRGLEKLLEHLTLQNDAFSSSNKLLMNYYKTLKIQTCNLMSLIKALICITNPNSLSQEDENCALIVNTCKLKWVESLYNFLNITEHDLETIVISPIIESYSLSEAKFELKMSLIKSELNLQKDSLYKNFYSNIIGSLNLIHDSKGIREFVFEALNLFQDKKLENSVTNEEPLFNIFLVKLFNNHNSEEAILITSNQNEGSSQIFCERLNFVDPSKYFCFDKCILFNKFNLRFLVYNSAGGLCWSDRICDMNTQFLQDYFFLFKFDNPKRKLIFNIISSLNQFISNFMINSIDALNIDQYNNALKLNQNCEFQNTNNSLLENKPSEPLSPIETFNTINKVLSSNDSLLSTSIIKPGNTIQSSIINSINTFTSCVSQEIHLDKIDISSNQVTNFSDSSLPIIQRSNSNTTTLSEFIGERNNHTSSSETQNSINIDFFYENDLHSHEWVLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYU4</accession>
    <name>Q5CYU4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein with MYND plus SET domains plus 5 Ank repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628286.1">
        <property type="nucleotide sequence ID" value="XM_628284.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CYU4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYU4"/>
    <dbReference type="GeneID" id="3371995"/>
    <dbReference type="KEGG" id="cpv:cgd7_980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_980"/>
    <dbReference type="InParanoid" id="Q5CYU4"/>
    <dbReference type="OMA" id="NGYNPFE"/>
    <dbReference type="OrthoDB" id="430364at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.2220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053010">
        <property type="entry name" value="SET_SmydA-8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455:SF5">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="980"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1013"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1078"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1383"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1393"/>
            <end position="1404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1560" mass="176147" checksum="71DF364797FEAAF5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPM7</accession>
    <name>A3FPM7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_1140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388373.1">
        <property type="nucleotide sequence ID" value="XM_001388336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPM7"/>
    <dbReference type="STRING" id="353152.A3FPM7"/>
    <dbReference type="GeneID" id="3371872"/>
    <dbReference type="KEGG" id="cpv:cgd7_1140"/>
    <dbReference type="InParanoid" id="A3FPM7"/>
    <dbReference type="OMA" id="VHRQNAY"/>
    <dbReference type="OrthoDB" id="344009at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="16"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="375"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="632"/>
            <end position="700"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="155"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="765" mass="90917" checksum="D571F120CFAFF294" modified="2007-04-03" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPP3</accession>
    <name>A3FPP3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">FALZ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_2720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388389.1">
        <property type="nucleotide sequence ID" value="XM_001388352.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPP3"/>
    <dbReference type="GeneID" id="3371831"/>
    <dbReference type="KEGG" id="cpv:cgd7_2720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2720"/>
    <dbReference type="InParanoid" id="A3FPP3"/>
    <dbReference type="OMA" id="CKESHIN"/>
    <dbReference type="OrthoDB" id="422637at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 4" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Bromo" evidence="5">
        <location>
            <begin position="1690"/>
            <end position="1760"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1782" mass="204715" checksum="DB331C4E51F3343A" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPS4</accession>
    <name>A3FPS4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">OSK4, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388303.1">
        <property type="nucleotide sequence ID" value="XM_001388266.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPS4"/>
    <dbReference type="GeneID" id="3375928"/>
    <dbReference type="KEGG" id="cpv:cgd6_650"/>
    <dbReference type="InParanoid" id="A3FPS4"/>
    <dbReference type="OMA" id="QDERNIK"/>
    <dbReference type="OrthoDB" id="193931at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12122">
        <property type="entry name" value="AMPKA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000003">
        <property type="entry name" value="Non-specific serine/threonine protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.80">
        <property type="entry name" value="Kinase associated domain 1, KA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028375">
        <property type="entry name" value="KA1/Ssp2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF82">
        <property type="entry name" value="KP78A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103243">
        <property type="entry name" value="KA1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="21"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="422"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="600"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="423"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="609"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="632"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="677"/>
            <end position="701"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="859" mass="97026" checksum="6591CF7FF9EF6524" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPV1</accession>
    <name>A3FPV1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uvb-resistance protein uvr8, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_2770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388330.1">
        <property type="nucleotide sequence ID" value="XM_001388293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPV1"/>
    <dbReference type="STRING" id="353152.A3FPV1"/>
    <dbReference type="GeneID" id="3375955"/>
    <dbReference type="KEGG" id="cpv:cgd6_2770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2770"/>
    <dbReference type="InParanoid" id="A3FPV1"/>
    <dbReference type="OMA" id="QAYSWGW"/>
    <dbReference type="OrthoDB" id="10256179at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RCC1-like" evidence="5">
        <location>
            <begin position="7"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="8"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="61"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="111"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="169"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="221"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="274"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="327"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="385"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="459"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF25390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="487" mass="52530" checksum="D42D267683A315E5" modified="2007-04-03" version="1">MGQNLSKSGVVVWGSTEYGQHGSKGEEVSPGPHLVDGLRHLSSISKVSCGSNYSAAITNSGDLILWGYGGCGQLGFGNLEDCLVPRVNLSLKNVIQVACSDRHTAAILSNGELYTWGCSKNGKLGHGQFELSISNNVVSQPMKVKALEGEKVIQVSCGSYHTGCLTDDKKALTWGLGLQGRLGHGDTQDIFTPKLIESLAGLPIKEISCGGHHTAILLVTGKLYMFGGGAFGKLGFGSTDDVLIPRLLEGPLEDIQITKVSLGSQHSAAVTKCGKVYTWGQGGRLGHIFNGPEHDFLSPKRLSNLEKAFIVDISCGNSHSVALSDVGDIYTWGMTKNIGHGIQGIHPNMPSKHPILQNKNIVQVVCSSSHSIALSDIGALVQKSSETRKPQSLAEDQEPKKADQSIEEFKTGLDSLIRRKILQGIKDKLKAGGDREKIEYLMDELEKSEEQNAVLVSLLDVSVRKLEILRKENEELRSKLELTRTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ86</accession>
    <name>A3FQ86_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Bromo domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_2690</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="submission" date="2018-03" db="PDB data bank">
            <title>Crystal structure of Cryptosporidium parvum bromodomain cgd2_2690.</title>
            <authorList>
                <consortium name="Structural Genomics Consortium (SGC)"/>
                <person name="Lin L."/>
                <person name="Dong A."/>
                <person name="Bountra C."/>
                <person name="Arrowsmith C.H."/>
                <person name="Edwards A.M."/>
                <person name="Hui R."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.38 ANGSTROMS) OF 3-107</scope>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388222.1">
        <property type="nucleotide sequence ID" value="XM_001388185.1"/>
    </dbReference>
    <dbReference type="PDB" id="6CW0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.38 A"/>
        <property type="chains" value="A/B=3-107"/>
    </dbReference>
    <dbReference type="PDBsum" id="6CW0"/>
    <dbReference type="AlphaFoldDB" id="A3FQ86"/>
    <dbReference type="SMR" id="A3FQ86"/>
    <dbReference type="STRING" id="353152.A3FQ86"/>
    <dbReference type="GeneID" id="3373550"/>
    <dbReference type="KEGG" id="cpv:cgd2_2690"/>
    <dbReference type="InParanoid" id="A3FQ86"/>
    <dbReference type="OrthoDB" id="21449at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050935">
        <property type="entry name" value="Bromo_chromatin_reader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880:SF225">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN BET-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22880">
        <property type="entry name" value="FALZ-RELATED BROMODOMAIN-CONTAINING PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1 2" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Bromo" evidence="3">
        <location>
            <begin position="18"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="6CW0"/>
        </source>
    </evidence>
    <sequence length="205" mass="24231" checksum="DE1C1784508001DC" modified="2007-04-03" version="1">MIMEDYSREYSEVLLQLKELQDSEAFLEPVNWKKLGLDDYPDIVKNPMDLKTIGKKIKANFYTKAEQFWADIDLIWHNCQLYNHESSEVYQQSIRMQDAANNLRDMLFPSISKKINKRKYEYDSHTESEDEDSSNILKKTLLCQRMSRLSPELLALVVRHIYSQDQQIIQHSGEHKFSIDIDFMNNQLFSTTSALTKRLLRLQLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQA0</accession>
    <name>A3FQA0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Programmed cell death 2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_3420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388236.1">
        <property type="nucleotide sequence ID" value="XM_001388199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQA0"/>
    <dbReference type="STRING" id="353152.A3FQA0"/>
    <dbReference type="GeneID" id="3373540"/>
    <dbReference type="KEGG" id="cpv:cgd2_3420"/>
    <dbReference type="InParanoid" id="A3FQA0"/>
    <dbReference type="OMA" id="TVYVFCC"/>
    <dbReference type="OrthoDB" id="443682at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298">
        <property type="entry name" value="PCDC2 PROGRAMMED CELL DEATH PROTEIN 2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12298:SF4">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="2">
        <location>
            <begin position="229"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="179"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="179"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="329" mass="37786" checksum="A32DD10BF0AD39AF" modified="2007-04-03" version="1">MNDVLLGYLEKPRTPLVLDSRYFPSKFGGKPAWLNPQNLPQYRDLQCNSCGTRMRFLLQVYAPQDDREDLFHRSIFLFICTNCTCSVQAFRCQLPRMNDYYDYNPAPTSFLFEDVNPEETILELKELKFNNICNTCGLPLSTESKCQQSNTHDKCNAIDSGAGKVILDEFSLDIEICSTDEEDEDDDQEETQDDNFENDPDEEMTPITGENDLGLEELPDQLDNINKKDVLFDKFINNSRKYPGHIIRYSHNGSPLWISDKNIPSETPQKCPLCNSNRVFEFQIQPEAIVLGNLPSKVEFGVIAIFTCSKNCRIDYYAPECVLIQNNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQH8</accession>
    <name>A3FQH8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd5_1180</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388262.1">
        <property type="nucleotide sequence ID" value="XM_001388225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQH8"/>
    <dbReference type="FunCoup" id="A3FQH8">
        <property type="interactions" value="441"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQH8"/>
    <dbReference type="GeneID" id="3373364"/>
    <dbReference type="KEGG" id="cpv:cgd5_1180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1180"/>
    <dbReference type="InParanoid" id="A3FQH8"/>
    <dbReference type="OMA" id="VIHNVYS"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031422">
        <property type="term" value="C:RecQ family helicase-topoisomerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000003">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF21">
        <property type="entry name" value="DNA TOPOISOMERASE 3-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="46"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="9">
        <location>
            <begin position="212"/>
            <end position="669"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="814" mass="93393" checksum="803AC55406820F75" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQI0</accession>
    <name>A3FQI0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_1340</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388264.1">
        <property type="nucleotide sequence ID" value="XM_001388227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQI0"/>
    <dbReference type="FunCoup" id="A3FQI0">
        <property type="interactions" value="90"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQI0"/>
    <dbReference type="GeneID" id="3373362"/>
    <dbReference type="KEGG" id="cpv:cgd5_1340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1340"/>
    <dbReference type="InParanoid" id="A3FQI0"/>
    <dbReference type="OMA" id="WSLHGKN"/>
    <dbReference type="OrthoDB" id="336771at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003865">
        <property type="term" value="F:3-oxo-5-alpha-steroid 4-dehydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016095">
        <property type="term" value="P:polyprenol catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001104">
        <property type="entry name" value="3-oxo-5_a-steroid_4-DH_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039698">
        <property type="entry name" value="Dfg10/SRD5A3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624">
        <property type="entry name" value="DFG10 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14624:SF0">
        <property type="entry name" value="POLYPRENOL REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02544">
        <property type="entry name" value="Steroid_dh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50244">
        <property type="entry name" value="S5A_REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="131"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="193"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="228"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="domain" description="3-oxo-5-alpha-steroid 4-dehydrogenase C-terminal" evidence="6">
        <location>
            <begin position="151"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="273" mass="31776" checksum="AD471658D9E4AF3B" modified="2007-04-03" version="1">MQEIDYKLVNGTHSLLTTYFLVSTVAVIFSSVVRFANLITTHGKLRKKNLSSENIGSTSTDKVIYLILGLSVNKGWFRYFYLVGVFTTLICVYLGYPNCHRLLFFLIHVIRRLYEEVFISYHNTNYSKMSIFVFLFGISYYIIMPITLLATQDFYGKFVVLQYISFAAFSLVQYKSHVKLSNIRRANSEEYGIPYGGMFKFVSCPHYFSEIGIYISLFFDAIFNSNNLHIAAALLYIISCMYLNAIRAHKWYINYYKESYLSLNRKAIIPYIV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQM3</accession>
    <name>A3FQM3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RNA binding protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_3410</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388078.1">
        <property type="nucleotide sequence ID" value="XM_001388041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQM3"/>
    <dbReference type="FunCoup" id="A3FQM3">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="GeneID" id="3372772"/>
    <dbReference type="KEGG" id="cpv:cgd4_3410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3410"/>
    <dbReference type="InParanoid" id="A3FQM3"/>
    <dbReference type="OMA" id="ILECKVM"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00201">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000359">
        <property type="entry name" value="CUGBP Elav-like family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.70.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001202">
        <property type="entry name" value="WW_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036020">
        <property type="entry name" value="WW_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00397">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00456">
        <property type="entry name" value="WW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51045">
        <property type="entry name" value="WW domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01159">
        <property type="entry name" value="WW_DOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50020">
        <property type="entry name" value="WW_DOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="306"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="406"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="domain" description="WW" evidence="4">
        <location>
            <begin position="690"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="735"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="856"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="31"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="71"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="84"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="94"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="906" mass="99601" checksum="6A2B7241A03F7128" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQN6</accession>
    <name>A3FQN6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">thioredoxin-dependent peroxiredoxin</fullName>
            <ecNumber evidence="2">1.11.1.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd4_740</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8 14">
            <text>a hydroperoxide + [thioredoxin]-dithiol = an alcohol + [thioredoxin]-disulfide + H2O</text>
            <dbReference type="Rhea" id="RHEA:62620"/>
            <dbReference type="Rhea" id="RHEA-COMP:10698"/>
            <dbReference type="Rhea" id="RHEA-COMP:10700"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:35924"/>
            <dbReference type="ChEBI" id="CHEBI:50058"/>
            <dbReference type="EC" id="1.11.1.24"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.11.1.24" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAZ51242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388054.1">
        <property type="nucleotide sequence ID" value="XM_001388017.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQN6"/>
    <dbReference type="SMR" id="A3FQN6"/>
    <dbReference type="FunCoup" id="A3FQN6">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQN6"/>
    <dbReference type="GeneID" id="3372626"/>
    <dbReference type="KEGG" id="cpv:cgd4_740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_740"/>
    <dbReference type="InParanoid" id="A3FQN6"/>
    <dbReference type="OMA" id="FWYPKDF"/>
    <dbReference type="OrthoDB" id="185659at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008379">
        <property type="term" value="F:thioredoxin peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033554">
        <property type="term" value="P:cellular response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042744">
        <property type="term" value="P:hydrogen peroxide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03015">
        <property type="entry name" value="PRX_Typ2cys"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000003">
        <property type="entry name" value="Peroxiredoxin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000866">
        <property type="entry name" value="AhpC/TSA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050217">
        <property type="entry name" value="Peroxiredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024706">
        <property type="entry name" value="Peroxiredoxin_AhpC-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019479">
        <property type="entry name" value="Peroxiredoxin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10681:SF164">
        <property type="entry name" value="THIOREDOXIN PEROXIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10417">
        <property type="entry name" value="1-cysPrx_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00578">
        <property type="entry name" value="AhpC-TSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000239">
        <property type="entry name" value="AHPC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 9" id="KW-0049">Antioxidant</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5 9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="3 9 12" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="7 9" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="11">
        <location>
            <begin position="3"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="active site" description="Cysteine sulfenic acid (-SOH) intermediate; for peroxidase activity" evidence="10">
        <location>
            <position position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00049091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRNR" id="PIRNR000239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR000239-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="196" mass="21772" checksum="61463C697AC89818" modified="2007-04-03" version="1">MSTLVRKLAPNFTAEAVMADGSFKKVSLSDYRGKYVVLFFYPLNFTFVCPSEILAFNQAQKDFEKLGVQLLAVSVDSQYSHAAWRRTPLEQGGIGPVNFPLISDSSHSISKNYGVLLEEEGIALRGLFIIDKEGVVRSEVIYDLPLGRSVEETLRVIDALQFTETYGEVCPANWKKGQKGMSATHEGVSSYLKDSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQP7</accession>
    <name>A3FQP7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin-conjugating enzyme e2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the ubiquitin-conjugating enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAZ51221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388416.1">
        <property type="nucleotide sequence ID" value="XM_001388379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQP7"/>
    <dbReference type="FunCoup" id="A3FQP7">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQP7"/>
    <dbReference type="GeneID" id="3372479"/>
    <dbReference type="KEGG" id="cpv:cgd8_220"/>
    <dbReference type="InParanoid" id="A3FQP7"/>
    <dbReference type="OrthoDB" id="10249039at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd23794">
        <property type="entry name" value="UBCc_UBE2F_UBE2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050113">
        <property type="entry name" value="Ub_conjugating_enzyme"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023313">
        <property type="entry name" value="UBQ-conjugating_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24067">
        <property type="entry name" value="UBIQUITIN-CONJUGATING ENZYME E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00179">
        <property type="entry name" value="UQ_con"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00212">
        <property type="entry name" value="UBCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00183">
        <property type="entry name" value="UBC_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UBC core" evidence="5">
        <location>
            <begin position="31"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU362109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="190" mass="21868" checksum="FF4F8BDAAEAE7622" modified="2007-04-03" version="1">MLSLINSGYIYINSIYYRPKFSLKAKTNMDVSLLRLRKEFEDVGLPEFCKVKFNTETALDNDTIENLCDTSKLDLDNISNCFVVVLQPKEGIWTDKTLQFIIRVPKEYPFKPPKVKCLSKILHPNIDKLGHVCINIIREDWKPTLTISIVICGLLNLLIEPSNSDPFNEFASILFESNLSLFKSINRSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQS0</accession>
    <name>A3FQS0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="13">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd3_250</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PPP phosphatase family. BSU subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="13"/>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAZ51203.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388090.1">
        <property type="nucleotide sequence ID" value="XM_001388053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQS0"/>
    <dbReference type="STRING" id="353152.A3FQS0"/>
    <dbReference type="GeneID" id="3372327"/>
    <dbReference type="KEGG" id="cpv:cgd3_250"/>
    <dbReference type="InParanoid" id="A3FQS0"/>
    <dbReference type="OMA" id="FRHTSWM"/>
    <dbReference type="OrthoDB" id="309851at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009742">
        <property type="term" value="P:brassinosteroid mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.80">
        <property type="entry name" value="Kelch-type beta propeller"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015915">
        <property type="entry name" value="Kelch-typ_b-propeller"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012391">
        <property type="entry name" value="Ser/Thr_prot_Pase_BSU1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46422">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE BSL3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46422:SF7">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE BSL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24681">
        <property type="entry name" value="Kelch_KLHDC2_KLHL20_DRC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036363">
        <property type="entry name" value="PPP_BSU1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117281">
        <property type="entry name" value="Kelch motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0880">Kelch repeat</keyword>
    <keyword evidence="9" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="15">
        <location>
            <begin position="528"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="242"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="262"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAZ51203.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="772" mass="87429" checksum="320FE76EC4399132" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPJ9</accession>
    <name>Q5CPJ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Leucine rich repeat (LRR) protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625350.1">
        <property type="nucleotide sequence ID" value="XM_625350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPJ9"/>
    <dbReference type="STRING" id="353152.Q5CPJ9"/>
    <dbReference type="GeneID" id="3375653"/>
    <dbReference type="KEGG" id="cpv:cgd6_100"/>
    <dbReference type="InParanoid" id="Q5CPJ9"/>
    <dbReference type="OMA" id="IRQFCFG"/>
    <dbReference type="OrthoDB" id="277458at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025875">
        <property type="entry name" value="Leu-rich_rpt_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050836">
        <property type="entry name" value="SDS22/Internalin_LRR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652:SF7">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46652">
        <property type="entry name" value="LEUCINE-RICH REPEAT AND IQ DOMAIN-CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00560">
        <property type="entry name" value="LRR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12799">
        <property type="entry name" value="LRR_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00365">
        <property type="entry name" value="LRR_SD22"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="295"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="328" mass="37362" checksum="3893036B7906ABB9" modified="2005-04-12" version="1" fragment="single">DKHKYKVFVDFSNYYFELMSKNLSIVELSKYVPNGDILGSQELKLRELEITGIDELTQAKNLRKIDVSKNKLESVSFLKYCWNLTDINLSNNNLTSVDEICNLENVKILNISNNSIKSIENLCRSPGLQKSLKVLIANHNKIRYIPDLSHFKELETVILSHNEAIEIENPKNHCPKLKKMSLSNNCLKQFPFSLNFNMVQELRLNNNKILSLPSDITYMGNIKILELGHNFITEIDPLLSLTKLKSLNISKNPCIIAEGTEGDNSNSIKTLNLIKEKLPSLDSLNGSFISKSNDKKRINKKKGIKNENKKKFSTGKPNSLNKKIIKKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPM6</accession>
    <name>Q5CPM6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625395.1">
        <property type="nucleotide sequence ID" value="XM_625395.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPM6"/>
    <dbReference type="GeneID" id="3372360"/>
    <dbReference type="KEGG" id="cpv:cgd2_260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_260"/>
    <dbReference type="InParanoid" id="Q5CPM6"/>
    <dbReference type="OrthoDB" id="340835at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="218" mass="25001" checksum="874E086FD7F6CA9D" modified="2005-04-12" version="1">MKESEKEKTVSSNREFLEINEENNSNRLEDLVLVVDHNKTNKNNIINFKEKDDDSQNKLPPWKRKPISLDNDILKRAKNFLSLCETIGNEKVTQSYNEDKHVVMNVHMGVFDINGKLPEDSSLSNNEIVDVSNLDFKTSQDNELCQIERDEDDSDDNDESDNYEDDITGSSFRYDPDSKSSLEEQMAIHKMLTQSKSGNGSSKKNKNFVQVISSKDNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPP9</accession>
    <name>Q5CPP9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_10</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625372.1">
        <property type="nucleotide sequence ID" value="XM_625372.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPP9"/>
    <dbReference type="STRING" id="353152.Q5CPP9"/>
    <dbReference type="GeneID" id="3372344"/>
    <dbReference type="KEGG" id="cpv:cgd2_10"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_10"/>
    <dbReference type="InParanoid" id="Q5CPP9"/>
    <dbReference type="OrthoDB" id="343728at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="445" mass="55458" checksum="2297FFC8F3BCD44C" modified="2005-04-12" version="1">MVHTTNNEFQDFDKYSSAIAHHTQKTVSRIIKEWYLYTLKQKILLELESYVGNNRKKKIKSKILREWFELSMKQKLNTVKEEYILNKKNQQLLKNSLQYWYKDHYLNKKNEFKIYCHIKKFYFSHLIKQVLQLWYSEFINQRKIQKFQKDKLQKKIFFLWYYEYINLLTIRNELEISKKRRIIFGYLEYIHLKKKRKEILKEKSYIIEKNKLNKLFNNWIILLQYSMNKRYTILQWQINLLNNKMLQIIKEWKIIIYKKKQDKFKYQFIKTKYENNIQIFVFNLWYILAQESYREKTMLIISGLSARRQLLMNGFHSFKQYLIHRKQSKILKEKSCLFLANYVLMVFQRNSSNYAKHKIQLQHATYIFQINNLKIYWKKWFEYINSIRIYKSKSQILINNYNKRILEKTYKIWNYVWFKTITNKMIIDCIQTKININIKEKYPIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPW5</accession>
    <name>Q5CPW5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625514.1">
        <property type="nucleotide sequence ID" value="XM_625514.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPW5"/>
    <dbReference type="GeneID" id="3372458"/>
    <dbReference type="KEGG" id="cpv:cgd8_530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_530"/>
    <dbReference type="InParanoid" id="Q5CPW5"/>
    <dbReference type="OMA" id="IGENYLH"/>
    <dbReference type="OrthoDB" id="343972at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="46"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="86"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="212"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="238" mass="27175" checksum="D5257A0E55C0C141" modified="2005-04-12" version="1">MALSISIFPPRIWSKIISRTNGRSLDIFKYCCCCTSSTTKALYRFISIWSGFLLIFNILILLLCLRTSNKYPLFLKYLFPKLSEALSVEIGIIYILLYIISASNIITGFVGAITTYSYNIIALKIYMVCNYLNIIKDIIFFIVINILLNKWHIAFIHVVTFFFMLFLIFILIGLLSSFVAENLLYILEEERDESSTAQNTETASDSTNSRIAKNDENGNKDLEVAKDDETNNNSAIQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPY9</accession>
    <name>Q5CPY9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625490.1">
        <property type="nucleotide sequence ID" value="XM_625490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPY9"/>
    <dbReference type="STRING" id="353152.Q5CPY9"/>
    <dbReference type="GeneID" id="3372507"/>
    <dbReference type="KEGG" id="cpv:cgd8_270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_270"/>
    <dbReference type="InParanoid" id="Q5CPY9"/>
    <dbReference type="OMA" id="ILNCQTK"/>
    <dbReference type="OrthoDB" id="498611at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004594">
        <property type="term" value="F:pantothenate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004567">
        <property type="entry name" value="Type_II_PanK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280:SF20">
        <property type="entry name" value="4'-PHOSPHOPANTETHEINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12280">
        <property type="entry name" value="PANTOTHENATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03630">
        <property type="entry name" value="Fumble"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="373" mass="42985" checksum="C6175EDC49F15D7C" modified="2005-04-12" version="1">MGNSLGVEIFRNQADICIAINELTSKKEKVLILEKIIKRDEMKEKFVILGGSLKDIELEETKSQRFLLIFIRTSLLDFKRIILEIMEEIQKKIQISVMVEDKQNQESFYLLKGSLGTDFDKLEVLLYEKESTFDPVRILKHNFELEDFLERYTFKNNFTKTLGIFNCLDDQEPIQLQSLNNNMVDLTHFVHINIGKSCTEFLHFTENSCSKRVGNIEIGEYTFWGLVNILDLKIENMEDIDKIVSKGNIQNCDLIVKDIYGQSYPEINLEGDSVASSLGKLQFLNHDQKNFSPEDLIKSIVILLTNQLVQKGILHSQILQENNIIISGFITSSPKIMAAIHNTFQVLSDKFNVFFIKSIINTACICPNFEIKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ04</accession>
    <name>Q5CQ04_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625475.1">
        <property type="nucleotide sequence ID" value="XM_625475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ04"/>
    <dbReference type="GeneID" id="3372495"/>
    <dbReference type="KEGG" id="cpv:cgd8_110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_110"/>
    <dbReference type="InParanoid" id="Q5CQ04"/>
    <dbReference type="OMA" id="KDWIDSG"/>
    <dbReference type="OrthoDB" id="342915at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="135" mass="14758" checksum="67EA9D7B55B9666D" modified="2005-04-12" version="1">MLGVTKLPGHGSSTNDQNSKDDPSKRVNNCQVQSPELYKRFLVSTGVYALFGTIISGTIGSIALKSPISRRFALGVGFGAGLGWGVKSANDFIKYTEKRNFVPPFPKSSDEWIDKGVLTFQKFKNALKNAVDKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ20</accession>
    <name>Q5CQ20_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_4450</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625606.1">
        <property type="nucleotide sequence ID" value="XM_625606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ20"/>
    <dbReference type="GeneID" id="3372549"/>
    <dbReference type="KEGG" id="cpv:cgd5_4450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4450"/>
    <dbReference type="InParanoid" id="Q5CQ20"/>
    <dbReference type="OrthoDB" id="343713at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1057"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1096" mass="129838" checksum="89AC5344DCABC158" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ53</accession>
    <name>Q5CQ53_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_4100</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87558.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625573.1">
        <property type="nucleotide sequence ID" value="XM_625573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ53"/>
    <dbReference type="GeneID" id="3372525"/>
    <dbReference type="KEGG" id="cpv:cgd5_4100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4100"/>
    <dbReference type="InParanoid" id="Q5CQ53"/>
    <dbReference type="OMA" id="NSCRINE"/>
    <dbReference type="OrthoDB" id="329742at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87558.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="553" mass="62085" checksum="447AAF0A9C4EA689" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ84</accession>
    <name>Q5CQ84_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative arginine N-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd5_3770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>L-arginyl-[protein] + 2 S-adenosyl-L-methionine = N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:48096"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11991"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61897"/>
            <dbReference type="EC" id="2.1.1.319"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:48097"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625542.1">
        <property type="nucleotide sequence ID" value="XM_625542.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ84"/>
    <dbReference type="FunCoup" id="Q5CQ84">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ84"/>
    <dbReference type="GeneID" id="3372557"/>
    <dbReference type="KEGG" id="cpv:cgd5_3770"/>
    <dbReference type="InParanoid" id="Q5CQ84"/>
    <dbReference type="OMA" id="YSHFAIH"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 6 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="8">
        <location>
            <begin position="491"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="245"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="665" mass="76619" checksum="AECD482490A4DE6F" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQF4</accession>
    <name>Q5CQF4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Poly(A) polymerase</fullName>
            <ecNumber evidence="11">2.7.7.19</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd4_930</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Polymerase that creates the 3'-poly(A) tail of mRNA's.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>RNA(n) + ATP = RNA(n)-3'-adenine ribonucleotide + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:11332"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17347"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="ChEBI" id="CHEBI:173115"/>
            <dbReference type="EC" id="2.7.7.19"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="13">Binds 2 magnesium ions. Also active with manganese.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.19" evidence="11"/>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625694.1">
        <property type="nucleotide sequence ID" value="XM_625694.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQF4"/>
    <dbReference type="FunCoup" id="Q5CQF4">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQF4"/>
    <dbReference type="GeneID" id="3372690"/>
    <dbReference type="KEGG" id="cpv:cgd4_930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_930"/>
    <dbReference type="InParanoid" id="Q5CQF4"/>
    <dbReference type="OMA" id="PAYPAMC"/>
    <dbReference type="OrthoDB" id="412748at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990817">
        <property type="term" value="F:poly(A) RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031123">
        <property type="term" value="P:RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05402">
        <property type="entry name" value="NT_PAP_TUTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.460.10:FF:000002">
        <property type="entry name" value="Poly(A) polymerase alpha, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1410.10:FF:000001">
        <property type="entry name" value="Putative poly(A) polymerase gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1410.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.590">
        <property type="entry name" value="Poly(A) polymerase predicted RNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011068">
        <property type="entry name" value="NuclTrfase_I-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007012">
        <property type="entry name" value="PolA_pol_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048840">
        <property type="entry name" value="PolA_pol_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007010">
        <property type="entry name" value="PolA_pol_RNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014492">
        <property type="entry name" value="PolyA_polymerase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682">
        <property type="entry name" value="POLY A POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10682:SF10">
        <property type="entry name" value="POLYNUCLEOTIDE ADENYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04928">
        <property type="entry name" value="PAP_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20750">
        <property type="entry name" value="PAP_NTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04926">
        <property type="entry name" value="PAP_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018425">
        <property type="entry name" value="PolyA_polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55003">
        <property type="entry name" value="PAP/Archaeal CCA-adding enzyme, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81631">
        <property type="entry name" value="PAP/OAS1 substrate-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly(A) polymerase nucleotidyltransferase" evidence="17">
        <location>
            <begin position="21"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase central" evidence="16">
        <location>
            <begin position="219"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="Poly(A) polymerase RNA-binding" evidence="15">
        <location>
            <begin position="373"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="544"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="544"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="100"/>
            <end position="102"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <begin position="113"/>
            <end position="115"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="115"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="167"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>2</label>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="228"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR018425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR018425-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF04928"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF20750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAK87645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="699" mass="79294" checksum="A3A2D6B8656F16FA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQG6</accession>
    <name>Q5CQG6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Yip1p like integral membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the YIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625682.1">
        <property type="nucleotide sequence ID" value="XM_625682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQG6"/>
    <dbReference type="STRING" id="353152.Q5CQG6"/>
    <dbReference type="GeneID" id="3372742"/>
    <dbReference type="KEGG" id="cpv:cgd4_800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_800"/>
    <dbReference type="InParanoid" id="Q5CQG6"/>
    <dbReference type="OrthoDB" id="440385at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005802">
        <property type="term" value="C:trans-Golgi network"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048280">
        <property type="term" value="P:vesicle fusion with Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045231">
        <property type="entry name" value="Yip1/4-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236">
        <property type="entry name" value="GOLGI MEMBRANE PROTEIN YIP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21236:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="374"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="431"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="463"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="102"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="211"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="264"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="106"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="211"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="264"/>
            <end position="286"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="481" mass="51918" checksum="FD7ADDD21FE878AB" modified="2005-04-12" version="1">MEQQVNGFGNTYNNSVGFGGINNNYDSNSGDRNANSLQFYTMSKLKNDGGGNEINSLVGMGGSGTTTGVGISGSSGNNKMFNNLNYSNYNYNLAKTNKGNLSQIPNSNYTSDNNNNYHNNSNNHYNHPPSLSFSPSSSSMNNNIPRKSPFNISESNNQFGGRSEPSIGGKGMMEMAMQGKPGNNDDFNQVVGSGNFGNVPLGPMSTPFPQNGSSRIQTGNGIFSSTGNSPNSMDHPIQQGGKTSSYSSLTSLIKLLNPGLLWTSGQDNSSSSSSSSYGGASTQQGGNDDDYDDILNEPPLLEELGIDPENIARYLKCVIMFKSIKEYSGNNNICTKSDGSPNNHEIEWDMAGPILLIACLGFFLLLAGKIHFGYIYGIGILSCIGTYILLNIMSSSQSIDLYTTMSILGYSLLPIVILAGISVVFSLRSKVGIIMAIFFNMWSTITASRFFEYTVSLKHQRYLIAYPIALLYASFTIVTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQI5</accession>
    <name>Q5CQI5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87670.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625663.1">
        <property type="nucleotide sequence ID" value="XM_625663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQI5"/>
    <dbReference type="STRING" id="353152.Q5CQI5"/>
    <dbReference type="GeneID" id="3372755"/>
    <dbReference type="KEGG" id="cpv:cgd4_580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_580"/>
    <dbReference type="InParanoid" id="Q5CQI5"/>
    <dbReference type="OMA" id="FAIHAYY"/>
    <dbReference type="OrthoDB" id="435275at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024943">
        <property type="entry name" value="Enhancer_polycomb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14898">
        <property type="entry name" value="ENHANCER OF POLYCOMB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="31"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="293"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="31"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="76"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="94"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="659"/>
            <end position="676"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87670.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="746" mass="83468" checksum="4DB0483E6C8FDB34" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQP9</accession>
    <name>Q5CQP9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_3780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625953.1">
        <property type="nucleotide sequence ID" value="XM_625953.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQP9"/>
    <dbReference type="GeneID" id="3372917"/>
    <dbReference type="KEGG" id="cpv:cgd4_3780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3780"/>
    <dbReference type="InParanoid" id="Q5CQP9"/>
    <dbReference type="OrthoDB" id="338782at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="122" mass="14701" checksum="F1508F582A0A195B" modified="2005-04-12" version="1">MEVCEWIKNLEMGVLAAIEITRNSILENSSNKEFNIMNEYDKLYNKIETLCKDQKEFYEYILESSVRDESDLERIKEFQDKIKLEKITQKLENSKEYLKECIKCELQNINYIDTLSIMWKHS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQR5</accession>
    <name>Q5CQR5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_3610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87766.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625937.1">
        <property type="nucleotide sequence ID" value="XM_625937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQR5"/>
    <dbReference type="GeneID" id="3372813"/>
    <dbReference type="KEGG" id="cpv:cgd4_3610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3610"/>
    <dbReference type="InParanoid" id="Q5CQR5"/>
    <dbReference type="OrthoDB" id="340978at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87766.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="582" mass="68491" checksum="2BD642B7541B4A40" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQV6</accession>
    <name>Q5CQV6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Alpha-1,3-glucosyltransferase</fullName>
            <ecNumber evidence="10">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd4_3120</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the ALG6/ALG8 glucosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87923.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625896.1">
        <property type="nucleotide sequence ID" value="XM_625896.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQV6"/>
    <dbReference type="STRING" id="353152.Q5CQV6"/>
    <dbReference type="GeneID" id="3372939"/>
    <dbReference type="KEGG" id="cpv:cgd4_3120"/>
    <dbReference type="InParanoid" id="Q5CQV6"/>
    <dbReference type="OMA" id="FQVPPMH"/>
    <dbReference type="OrthoDB" id="339981at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042281">
        <property type="term" value="F:dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004856">
        <property type="entry name" value="Glyco_trans_ALG6/ALG8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413">
        <property type="entry name" value="DOLICHYL GLYCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12413:SF1">
        <property type="entry name" value="DOLICHYL PYROPHOSPHATE MAN9GLCNAC2 ALPHA-1,3-GLUCOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03155">
        <property type="entry name" value="Alg6_Alg8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 10" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="208"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="233"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="326"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="355"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="450"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="485"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU363110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87923.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="532" mass="60998" checksum="9A24F01F0DF77A20" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQW7</accession>
    <name>Q5CQW7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625885.1">
        <property type="nucleotide sequence ID" value="XM_625885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQW7"/>
    <dbReference type="GeneID" id="3372989"/>
    <dbReference type="KEGG" id="cpv:cgd4_3010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3010"/>
    <dbReference type="InParanoid" id="Q5CQW7"/>
    <dbReference type="OMA" id="DQAEWIS"/>
    <dbReference type="OrthoDB" id="341182at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="160"/>
            <end position="194"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="271" mass="30879" checksum="6C95CE63C526054D" modified="2005-04-12" version="1">MDINDVTATVKTAFCNTQIAEAFAAAVVASSKGKENVIQESYDLEIKKLSNELNALKNCINDMQQSFLNKFGAGSNSKKTSEVNDSPICEENNITNEEFLNREWKTMQKYIYEHFKNQTEIQSKVKEIEDHIIHGKENFSLKSSEIHSLEKNLEVSTGHITTLAHLIENQKDKINLLEEKVGLLESKINRLDDRFVTNFQVLENVAKSTDSLMNMLNSQTKSWENSRKIFKKLSSDADYLLKRTADTFEENSIADELALLLKKFIDVMQGV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR08</accession>
    <name>Q5CR08_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 7">Phosphoinositide phospholipase C</fullName>
            <ecNumber evidence="1 7">3.1.4.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd4_2560</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H(+)</text>
            <dbReference type="Rhea" id="RHEA:33179"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17815"/>
            <dbReference type="ChEBI" id="CHEBI:58456"/>
            <dbReference type="ChEBI" id="CHEBI:203600"/>
            <dbReference type="EC" id="3.1.4.11"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.4.11" evidence="1 7"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87844.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625844.1">
        <property type="nucleotide sequence ID" value="XM_625844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR08"/>
    <dbReference type="STRING" id="353152.Q5CR08"/>
    <dbReference type="GeneID" id="3372851"/>
    <dbReference type="KEGG" id="cpv:cgd4_2560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2560"/>
    <dbReference type="InParanoid" id="Q5CR08"/>
    <dbReference type="OMA" id="HWQREMS"/>
    <dbReference type="OrthoDB" id="269822at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004435">
        <property type="term" value="F:phosphatidylinositol-4,5-bisphosphate phospholipase C activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051209">
        <property type="term" value="P:release of sequestered calcium ion into cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00275">
        <property type="entry name" value="C2_PLC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15898">
        <property type="entry name" value="EFh_PI-PLC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08558">
        <property type="entry name" value="PI-PLCc_eukaryota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001192">
        <property type="entry name" value="PI-PLC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000909">
        <property type="entry name" value="PLipase_C_PInositol-sp_X_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001711">
        <property type="entry name" value="PLipase_C_Pinositol-sp_Y"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336:SF36">
        <property type="entry name" value="1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE BETA-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10336">
        <property type="entry name" value="PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00388">
        <property type="entry name" value="PI-PLC-X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00387">
        <property type="entry name" value="PI-PLC-Y"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00390">
        <property type="entry name" value="PHPHLIPASEC"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00148">
        <property type="entry name" value="PLCXc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00149">
        <property type="entry name" value="PLCYc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50007">
        <property type="entry name" value="PIPLC_X_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50008">
        <property type="entry name" value="PIPLC_Y_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 7" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="5 7" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0807">Transducer</keyword>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="210"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="10">
        <location>
            <begin position="246"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="domain" description="PI-PLC Y-box" evidence="9">
        <location>
            <begin position="586"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="domain" description="C2" evidence="8">
        <location>
            <begin position="691"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012368"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023224"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50008"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87844.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="883" mass="100509" checksum="F5EE00A722B8C342" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR30</accession>
    <name>Q5CR30_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625822.1">
        <property type="nucleotide sequence ID" value="XM_625822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR30"/>
    <dbReference type="GeneID" id="3372889"/>
    <dbReference type="KEGG" id="cpv:cgd4_2340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2340"/>
    <dbReference type="InParanoid" id="Q5CR30"/>
    <dbReference type="OrthoDB" id="340448at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="149" mass="16738" checksum="64812D09B92C15DC" modified="2005-04-12" version="1">MNKSILKLLRALLILLSLILGFLSILAFAWITESNSEYSQYYLDGVKFSNEEKKVAFTDAINKACSFSEAYKINKKDAMENQQFSKFFSGRDPMIDPISYCETITSSKTPSIVTESILITIQILIFLISTVSNTKFVQGAPDAVTLIKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR34</accession>
    <name>Q5CR34_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">AD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625818.1">
        <property type="nucleotide sequence ID" value="XM_625818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR34"/>
    <dbReference type="FunCoup" id="Q5CR34">
        <property type="interactions" value="85"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR34"/>
    <dbReference type="GeneID" id="3372981"/>
    <dbReference type="KEGG" id="cpv:cgd4_2290"/>
    <dbReference type="InParanoid" id="Q5CR34"/>
    <dbReference type="OMA" id="FIHKTHP"/>
    <dbReference type="OrthoDB" id="1057137at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047574">
        <property type="entry name" value="AD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039683">
        <property type="entry name" value="Lsm12-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019181">
        <property type="entry name" value="LSM12_ABD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13542">
        <property type="entry name" value="LSM12 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09793">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00995">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52001">
        <property type="entry name" value="AD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AD" evidence="1">
        <location>
            <begin position="41"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS52001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="138" mass="15871" checksum="8DCD578794170D64" modified="2005-04-12" version="1" fragment="single">YFSEKDIRNGFSAFDVINSESISEVKPYSEGKCSEIDVDLPKNYVDIIKKREEIIISNAKSNIKYWGNNVTPMGQATFDFIHKTHPNCLWNNENIEVMGITVSPPYLPENCSGDDKRALERIRCVIEKFRERISGEPH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR70</accession>
    <name>Q5CR70_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_1880</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87891.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625782.1">
        <property type="nucleotide sequence ID" value="XM_625782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR70"/>
    <dbReference type="GeneID" id="3372897"/>
    <dbReference type="KEGG" id="cpv:cgd4_1880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1880"/>
    <dbReference type="InParanoid" id="Q5CR70"/>
    <dbReference type="OMA" id="WIHYTIN"/>
    <dbReference type="OrthoDB" id="339403at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87891.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1143" mass="131031" checksum="0FCF234DD16735A7" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRB2</accession>
    <name>Q5CRB2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd5_3500</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88043.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626274.1">
        <property type="nucleotide sequence ID" value="XM_626274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRB2"/>
    <dbReference type="GeneID" id="3373101"/>
    <dbReference type="KEGG" id="cpv:cgd5_3500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3500"/>
    <dbReference type="InParanoid" id="Q5CRB2"/>
    <dbReference type="OMA" id="CNILQQV"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="28"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="109"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="135"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="201"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="279"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="359"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="448"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88043.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="481" mass="53580" checksum="540FEB4287492677" modified="2005-04-12" version="1">MGKSKNSKIISEAEPLVMAKNKSSGFNAYFLVSLAFLQMLVSSGIILGWQSLANIIKDTGAYRFLCEDPSLPCVEEEVYLANLMSISQSVQMFSVLFLSILMDVIGPKFMAVCQFITALGTFMIAVGNPRGSIDYIWYGAILQNLCGCIYIPSFIHLSNLFPKGRAVIASTFSTLYGFSSLTFLVVQLIHSHFQTTLKVSLLPLAFIQAFFVLFSLLLPNRIIHLGDSCGFSLKKCGFYSIKGNTNEGNSENQVNVVRSDRENNSGFVQSKIKPLFRSIFSEMFVVQFLLEVLVVVSVNFYVSTLSLQIEELSGLSSIEERKKIGYYWSTIFTTVSPFGSIVGVLEGYLVDRYGLWKSALVPTILLVVCAIFKLVPNVSFQLLTFIAYTTSQEAVFSSAYSLFTLAIPTDVICTFAGVNLLLQSFPVGYLPQYLISLFSQNGWTFQEINFMLIPPTIIVGVIYVKFLYTLERKSKLQSINE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRF3</accession>
    <name>Q5CRF3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Plus3 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_3010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_626233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRF3"/>
    <dbReference type="STRING" id="353152.Q5CRF3"/>
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    <dbReference type="KEGG" id="cpv:cgd5_3010"/>
    <dbReference type="InParanoid" id="Q5CRF3"/>
    <dbReference type="OMA" id="PSVMWET"/>
    <dbReference type="OrthoDB" id="166375at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.200">
        <property type="entry name" value="Plus-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Plus-3_dom"/>
    </dbReference>
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        <property type="entry name" value="Plus3-like_sf"/>
    </dbReference>
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        <property type="entry name" value="Plus-3"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Plus3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159042">
        <property type="entry name" value="Plus3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51360">
        <property type="entry name" value="PLUS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Plus3" evidence="3">
        <location>
            <begin position="272"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="145"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="604"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="424"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="96"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="159"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="176"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="194"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="217"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="609"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="724" mass="84306" checksum="D5E7F5041DB22A4E" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRF4</accession>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_2990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
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            <taxon>Sar</taxon>
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            <taxon>Coccidia</taxon>
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            <taxon>Eimeriorina</taxon>
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            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_626232.1"/>
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    </dbReference>
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    <dbReference type="GeneID" id="3373246"/>
    <dbReference type="KEGG" id="cpv:cgd5_2990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2990"/>
    <dbReference type="InParanoid" id="Q5CRF4"/>
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    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
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        <property type="entry name" value="NOP9"/>
    </dbReference>
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        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
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        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13102:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="612"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="718"/>
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    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="725"/>
            <end position="735"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="764" mass="88569" checksum="8BEA132BA9E6FBFA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRF6</accession>
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        <submittedName>
            <fullName evidence="9">DNAj domain protein</fullName>
        </submittedName>
    </protein>
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    </gene>
    <organism evidence="9 10">
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        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
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                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
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            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="EAK88223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_626230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRF6"/>
    <dbReference type="STRING" id="353152.Q5CRF6"/>
    <dbReference type="GeneID" id="3373211"/>
    <dbReference type="KEGG" id="cpv:cgd5_2950"/>
    <dbReference type="InParanoid" id="Q5CRF6"/>
    <dbReference type="OMA" id="DTCGEEF"/>
    <dbReference type="OrthoDB" id="5894at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000046">
        <property type="entry name" value="dnaJ homolog subfamily C member 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051964">
        <property type="entry name" value="Chaperone_stress_response"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041661">
        <property type="entry name" value="ZN622/Rei1/Reh1_Znf-C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44029:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12756">
        <property type="entry name" value="zf-C2H2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50157">
        <property type="entry name" value="ZINC_FINGER_C2H2_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="34"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="334"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="domain" description="C2H2-type" evidence="8">
        <location>
            <begin position="548"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="379"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="505"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="263"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="389"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="416"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="429"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="460"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="531"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="588" mass="70293" checksum="3165F14E212067F9" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRI9</accession>
    <name>Q5CRI9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative leucine aminopeptidase of possible plant or bacterial origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_2600</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M17 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626197.1">
        <property type="nucleotide sequence ID" value="XM_626197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRI9"/>
    <dbReference type="FunCoup" id="Q5CRI9">
        <property type="interactions" value="120"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRI9"/>
    <dbReference type="GeneID" id="3373203"/>
    <dbReference type="KEGG" id="cpv:cgd5_2600"/>
    <dbReference type="InParanoid" id="Q5CRI9"/>
    <dbReference type="OMA" id="LGKMDGP"/>
    <dbReference type="OrthoDB" id="412814at2759"/>
    <dbReference type="BRENDA" id="3.4.11.1">
        <property type="organism ID" value="1728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070006">
        <property type="term" value="F:metalloaminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00433">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.220.10">
        <property type="entry name" value="Leucine Aminopeptidase, subunit E, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.10">
        <property type="entry name" value="Zn peptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011356">
        <property type="entry name" value="Leucine_aapep/pepB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043472">
        <property type="entry name" value="Macro_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000819">
        <property type="entry name" value="Peptidase_M17_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963:SF23">
        <property type="entry name" value="CYTOSOL AMINOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11963">
        <property type="entry name" value="LEUCINE AMINOPEPTIDASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00883">
        <property type="entry name" value="Peptidase_M17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00481">
        <property type="entry name" value="LAMNOPPTDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52949">
        <property type="entry name" value="Macro domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53187">
        <property type="entry name" value="Zn-dependent exopeptidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00631">
        <property type="entry name" value="CYTOSOL_AP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cytosol aminopeptidase" evidence="5">
        <location>
            <begin position="402"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS00631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="550" mass="61170" checksum="3C80CFB81E216165" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRL7</accession>
    <name>Q5CRL7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_2320</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88209.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626169.1">
        <property type="nucleotide sequence ID" value="XM_626169.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRL7"/>
    <dbReference type="FunCoup" id="Q5CRL7">
        <property type="interactions" value="323"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRL7"/>
    <dbReference type="GeneID" id="3373347"/>
    <dbReference type="KEGG" id="cpv:cgd5_2320"/>
    <dbReference type="InParanoid" id="Q5CRL7"/>
    <dbReference type="OMA" id="NEGTHFQ"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF1">
        <property type="entry name" value="PROHIBITIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3 6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Band 7" evidence="7">
        <location>
            <begin position="33"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88209.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="284" mass="31832" checksum="2E8D751692355975" modified="2005-04-12" version="1" fragment="single">LAFFMSRIEKGFNILANLGIMLVAGGSILASNSMYNVDAGHRAIKFSRIHGVQRRIYGEGTHFMLPWIERPVIFDIRARPRVVVSLTGSKDLQMVNITCRVLSRPDKEKLVEIYRNIGLDHDEKILPSIINEVLKSVVAQYNASQLLTMREDVSKTIRDLLVKRAQEFNIILDDVSLTHLSFSQDYEKAVESKQVAQQQAERAKYLVLKANEEKKSTIIKAEGEAKAAKLIGDAINENPAFIALKQVETYREISNILAKSTSKSLINLSSFLPSLPNSNLQSSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRN3</accession>
    <name>Q5CRN3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">CCHC-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88056.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626153.1">
        <property type="nucleotide sequence ID" value="XM_626153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRN3"/>
    <dbReference type="GeneID" id="3373114"/>
    <dbReference type="KEGG" id="cpv:cgd5_2140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2140"/>
    <dbReference type="InParanoid" id="Q5CRN3"/>
    <dbReference type="OrthoDB" id="344360at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="40"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="549"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88056.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="572" mass="66519" checksum="F431429789A93274" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRW5</accession>
    <name>Q5CRW5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_1220</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626071.1">
        <property type="nucleotide sequence ID" value="XM_626071.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRW5"/>
    <dbReference type="GeneID" id="3373065"/>
    <dbReference type="KEGG" id="cpv:cgd5_1220"/>
    <dbReference type="InParanoid" id="Q5CRW5"/>
    <dbReference type="OMA" id="RECVPAV"/>
    <dbReference type="OrthoDB" id="344277at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254460" evidence="2">
        <location>
            <begin position="25"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="354" mass="37942" checksum="255AB7532075F602" modified="2005-04-12" version="1">MNFLQVFSTLFFFLLLQFSKYALCEVNTITYSENKSEAWNSELGGNQITPSNIDESYVTNSKNASEGILTGIGGIDLPGMPLSTEYTNSTNLDSSKVLLGNDSTVKSSSFFNPMDLSHPFFQMKEQFFRPFRPVTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTXTTTHHTTTTXHYTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTAESLALNSPSLGITASNEVSQINSNSSQEIAKPNFFLPIDLNNPFFQMKEKFLNPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRY7</accession>
    <name>Q5CRY7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88141.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626049.1">
        <property type="nucleotide sequence ID" value="XM_626049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRY7"/>
    <dbReference type="GeneID" id="3373128"/>
    <dbReference type="KEGG" id="cpv:cgd5_980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_980"/>
    <dbReference type="InParanoid" id="Q5CRY7"/>
    <dbReference type="OMA" id="EYTCALI"/>
    <dbReference type="OrthoDB" id="339874at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="143"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="42"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="153"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88141.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="266" mass="31142" checksum="A685FE99386BC007" modified="2005-04-12" version="1">MDANILEMLDLEELIIIEGRLKNSILDLNKLIFELYNENCRILQHNLELNSLKNRSSNAKERIGKLLKNAFFPKFNKLEEFDSLSLTYNSKNDVCLSKYDKNDKALFNHCEETKNFIGKKSDLNNHFKQLKVMKYGQNSPLFKEVQDSDNHTSQDSNQCDLNPEPTSKINEGQAVNIEYGDMAKYEINLLINENNYVKIQFSEFENDQIREDFAKEIIKSIGLKPIYFDCIKNLLKHIESKSEHVENLIDIANLDPWENDHKFLRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS02</accession>
    <name>Q5CS02_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Leucine-rich repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_810</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626034.1">
        <property type="nucleotide sequence ID" value="XM_626034.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS02"/>
    <dbReference type="GeneID" id="3373138"/>
    <dbReference type="KEGG" id="cpv:cgd5_810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_810"/>
    <dbReference type="InParanoid" id="Q5CS02"/>
    <dbReference type="OMA" id="WCVDCSL"/>
    <dbReference type="OrthoDB" id="660555at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050576">
        <property type="entry name" value="Cilia_flagella_integrity"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001611">
        <property type="entry name" value="Leu-rich_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003591">
        <property type="entry name" value="Leu-rich_rpt_typical-subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973:SF9">
        <property type="entry name" value="LEUCINE-RICH REPEAT-CONTAINING PROTEIN 46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45973">
        <property type="entry name" value="PROTEIN PHOSPHATASE 1 REGULATORY SUBUNIT SDS22-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00364">
        <property type="entry name" value="LRR_BAC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00369">
        <property type="entry name" value="LRR_TYP"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52058">
        <property type="entry name" value="L domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51450">
        <property type="entry name" value="LRR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0966">Cell projection</keyword>
    <keyword evidence="4" id="KW-0969">Cilium</keyword>
    <keyword evidence="2" id="KW-0433">Leucine-rich repeat</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2116"/>
            <end position="2141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="2212"/>
            <end position="2265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2116"/>
            <end position="2132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="2217"/>
            <end position="2232"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="2240"/>
            <end position="2255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022614"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2338" mass="267008" checksum="B3BBCA5CE6E8769C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSD3</accession>
    <name>Q5CSD3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_3180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628134.1">
        <property type="nucleotide sequence ID" value="XM_628134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSD3"/>
    <dbReference type="GeneID" id="3371464"/>
    <dbReference type="KEGG" id="cpv:cgd1_3180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3180"/>
    <dbReference type="InParanoid" id="Q5CSD3"/>
    <dbReference type="OrthoDB" id="341726at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="456" mass="52916" checksum="8BD030C5F3C96475" modified="2005-04-12" version="1">MDSEFCIEDLIVSIYGTEMLLKQIKERQIRNCLYNWKYKSQLERELSLQKKKYNKYMLDGFYALARQTQSICMLFHTMKLIEYKKQRFAMDKLISNFKQSNNRQEAIMDKSRSCESTELENESELLSLDENTMLEFQQNLIRYFHGINSVVNIIESKKDKIFYYSFYKVKNFKGNEKQKTVISNQKIEINVTKDNLVAPSSSLNKPEVNDKENISSNTLGKQLNNGLTLNREELYFELIPEKKQFYTRKQNASFNNGPISNPSLERKTSNISEFTKQKQISRDFTQQSYGSSNHFHKQIGNNVVIGNNIIDFTHANPVLFSTIQSPVNSNPVLTIFPPHSPNFNFTNHANKGKYPQFNNNLNYANQLSSGSTPLNTTKYSKDNLPNINNTFSKNQLQHKPELGRNFTIKRYSSNDRKSPRSAEITKNILKPCINFTQDSTNLIQNITDSFKSAILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSF7</accession>
    <name>Q5CSF7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Golgi transport SNARE BOS1 secretory pathway protein, possible transmembrane or GPI anchor at C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_2920</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628110.1">
        <property type="nucleotide sequence ID" value="XM_628110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSF7"/>
    <dbReference type="STRING" id="353152.Q5CSF7"/>
    <dbReference type="GeneID" id="3371716"/>
    <dbReference type="KEGG" id="cpv:cgd1_2920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2920"/>
    <dbReference type="InParanoid" id="Q5CSF7"/>
    <dbReference type="OMA" id="LKYDSRH"/>
    <dbReference type="OrthoDB" id="158360at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012507">
        <property type="term" value="C:ER to Golgi transport vesicle membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031201">
        <property type="term" value="C:SNARE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000149">
        <property type="term" value="F:SNARE binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006906">
        <property type="term" value="P:vesicle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027027">
        <property type="entry name" value="GOSR2/Membrin/Bos1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230:SF1">
        <property type="entry name" value="GOLGI SNAP RECEPTOR COMPLEX MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21230">
        <property type="entry name" value="VESICLE TRANSPORT V-SNARE PROTEIN VTI1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028865">
        <property type="entry name" value="Membrin-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="194"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR028865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="220" mass="25437" checksum="989BD6AF91147D2A" modified="2005-04-12" version="1">MSLETLSALYPKATKSKNEAERLLEQFELGLDRSIALQQRLSAILNDFCRQVTELKQVLDKLKSSKSIDRSQEKIWDRRIDNLVSDSNSLRESISKQLDHIHKSQIEEQKKLSYSSPEKNSGVGALIREKAIWQESHIAIDHALEQARSIVFNLKNQNRMLKSVRKKALDMASRLGISHSLLSNIERRNLVDQILVYGCILLTSLIFITIYLFIHYVYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSK9</accession>
    <name>Q5CSK9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA-directed RNA polymerases I, II, and III subunit RPABC3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_2260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 4">Belongs to the eukaryotic RPB8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628058.1">
        <property type="nucleotide sequence ID" value="XM_628058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSK9"/>
    <dbReference type="FunCoup" id="Q5CSK9">
        <property type="interactions" value="486"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSK9"/>
    <dbReference type="GeneID" id="3371673"/>
    <dbReference type="KEGG" id="cpv:cgd1_2260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2260"/>
    <dbReference type="InParanoid" id="Q5CSK9"/>
    <dbReference type="OMA" id="KEDDKGW"/>
    <dbReference type="OrthoDB" id="10249565at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005570">
        <property type="entry name" value="RPABC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10917:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03870">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000779">
        <property type="entry name" value="RNA_pol_Rpb8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00658">
        <property type="entry name" value="RPOL8c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR000779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="144" mass="16496" checksum="7E81919D99793595" modified="2005-04-12" version="1">MSLPSCLFEDRFVINSVDSGKFDRIGRIRGRSVGFDADLILDINNELFPVREKESLYIGLSSQVSVNPNDIVWDNSGPQTLMDQYDYVMYGKIYRVEEKQSDRRSLYASFGGLLMSLTADKNLVGDFSLDMRLYCLVRRSEDII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSV5</accession>
    <name>Q5CSV5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RAD54 like SWI/SNF2 ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_1180</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627962.1">
        <property type="nucleotide sequence ID" value="XM_627962.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSV5"/>
    <dbReference type="FunCoup" id="Q5CSV5">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSV5"/>
    <dbReference type="GeneID" id="3371603"/>
    <dbReference type="KEGG" id="cpv:cgd1_1180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1180"/>
    <dbReference type="InParanoid" id="Q5CSV5"/>
    <dbReference type="OMA" id="CKIEFRD"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015616">
        <property type="term" value="F:DNA translocase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18004">
        <property type="entry name" value="DEXHc_RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000021">
        <property type="entry name" value="DNA repair and recombination protein RAD54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000332">
        <property type="entry name" value="DNA repair and recombination protein RAD54-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.850">
        <property type="entry name" value="SWI2/SNF2 ATPases, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="154"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="514"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="785"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="838"/>
            <end position="877"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="93"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="789"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="841"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="851"/>
            <end position="867"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="868"/>
            <end position="877"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="877" mass="98162" checksum="F2768F9262E6F86D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSX5</accession>
    <name>Q5CSX5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">RING finger containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_960</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627942.1">
        <property type="nucleotide sequence ID" value="XM_627942.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSX5"/>
    <dbReference type="GeneID" id="3371560"/>
    <dbReference type="KEGG" id="cpv:cgd1_960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_960"/>
    <dbReference type="InParanoid" id="Q5CSX5"/>
    <dbReference type="OrthoDB" id="344310at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="485" mass="55332" checksum="C1E727A06E0A9200" modified="2005-04-12" version="1">MNYYIPKKPKYPSYPRNGLSSALNNSKGTQFSQSFTTNNNLKQYNSVHSFNYKAAKSDINTNNAQDSVADRFEVDELHINNIGGNITATVYSLIPEWINNNYGMIQNKKSEFEQNPINTSNKFTYFGENHYDGNIVSNIEEECELAGNGFTKSINGNISAINNNNNNNNCNSGNKRPRHFFCFSCNQFKPRSTKARFKVCKHVSCYHCLRKALHVEYWAAKNDIWDKCRAECPFCHISLDWTKMKPYIVLSLEAKQFPLMSLCDAEERQGEAFQVIQSFFPKGVPSYIIYGNKIDFSVKPKVTQFLFGHYLELINGLDSYDKFFKPERVEQFCLDSCNKTLELENLNLTGSNKNDGFKPFKPIKDYNNSGNSSNSNSGSSITSKLEVHSQANIDPNYYSYAISYTSASTTAPSCNTTTICANIDTSVSSTLESEEEITTEYEVETEYEEGKRDYESNKNVAWARTYNIYPDIFVSWRRSLLNPPV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSY5</accession>
    <name>Q5CSY5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sen1p/ NAM7 like superfamily I RNA helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_830</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627932.1">
        <property type="nucleotide sequence ID" value="XM_627932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSY5"/>
    <dbReference type="FunCoup" id="Q5CSY5">
        <property type="interactions" value="24"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSY5"/>
    <dbReference type="GeneID" id="3371565"/>
    <dbReference type="KEGG" id="cpv:cgd1_830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_830"/>
    <dbReference type="InParanoid" id="Q5CSY5"/>
    <dbReference type="OMA" id="DENYDYC"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18042">
        <property type="entry name" value="DEXXQc_SETX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18808">
        <property type="entry name" value="SF1_C_Upf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000326">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045055">
        <property type="entry name" value="DNA2/NAM7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041679">
        <property type="entry name" value="DNA2/NAM7-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041677">
        <property type="entry name" value="DNA2/NAM7_AAA_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047187">
        <property type="entry name" value="SF1_C_Upf1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887">
        <property type="entry name" value="DNA2/NAM7 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10887:SF495">
        <property type="entry name" value="HELICASE SENATAXIN ISOFORM X1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13086">
        <property type="entry name" value="AAA_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13087">
        <property type="entry name" value="AAA_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA2/NAM7 helicase helicase" evidence="5">
        <location>
            <begin position="506"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="domain" description="DNA2/NAM7 helicase-like C-terminal" evidence="6">
        <location>
            <begin position="608"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="994" mass="113772" checksum="2E5056CD415DEE2A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT07</accession>
    <name>Q5CT07_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">V-type proton ATPase proteolipid subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd1_540</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Vacuole membrane</location>
            <topology evidence="9">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627910.1">
        <property type="nucleotide sequence ID" value="XM_627910.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT07"/>
    <dbReference type="STRING" id="353152.Q5CT07"/>
    <dbReference type="GeneID" id="3371374"/>
    <dbReference type="KEGG" id="cpv:cgd1_540"/>
    <dbReference type="InParanoid" id="Q5CT07"/>
    <dbReference type="OMA" id="TNGMPLY"/>
    <dbReference type="OrthoDB" id="433895at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18175">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18176">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6C_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000001">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011555">
        <property type="entry name" value="ATPase_proteolipid_su_C_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01100">
        <property type="entry name" value="V_ATP_synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <keyword evidence="9" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="57"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="129"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="18"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="94"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="167" mass="16986" checksum="05754575B524AF11" modified="2005-04-12" version="1" fragment="single">IKMAPPFCTPTATLFGMLGSTLATALSNFGAAYGTAKAGLAIASCGVMRPDLVMRSIIPAVMAGILGVYGLIVGVIICSQIRTDYSLYQGYCHLAAGLISGFSCAASGFTIGVAGDAGIRGTAQQSKLFVASMLILIFGEALAIYGIIVSLVLISSPSANNLCVPIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT24</accession>
    <name>Q5CT24_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CDC48 like AAA ATPase ortholog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627893.1">
        <property type="nucleotide sequence ID" value="XM_627893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT24"/>
    <dbReference type="FunCoup" id="Q5CT24">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT24"/>
    <dbReference type="GeneID" id="3371378"/>
    <dbReference type="KEGG" id="cpv:cgd1_330"/>
    <dbReference type="InParanoid" id="Q5CT24"/>
    <dbReference type="OMA" id="VWPAYPE"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097352">
        <property type="term" value="P:autophagosome maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051228">
        <property type="term" value="P:mitotic spindle disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19519">
        <property type="entry name" value="RecA-like_CDC48_r1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19528">
        <property type="entry name" value="RecA-like_CDC48_r2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000001">
        <property type="entry name" value="Cell division control 48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000079">
        <property type="entry name" value="Cell division cycle protein 48 homologue"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000003">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000012">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000048">
        <property type="entry name" value="Transitional endoplasmic reticulum ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.20.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005938">
        <property type="entry name" value="AAA_ATPase_CDC48"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009010">
        <property type="entry name" value="Asp_de-COase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004201">
        <property type="entry name" value="Cdc48_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003338">
        <property type="entry name" value="CDC4_N-term_subdom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01243">
        <property type="entry name" value="CDC48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02933">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02359">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM01072">
        <property type="entry name" value="CDC48_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01073">
        <property type="entry name" value="CDC48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50692">
        <property type="entry name" value="ADC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CDC48 N-terminal subdomain" evidence="6">
        <location>
            <begin position="46"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="CDC48" evidence="5">
        <location>
            <begin position="146"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="257"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="4">
        <location>
            <begin position="530"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="820" mass="90561" checksum="A272CF2B6CC02AEB" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT47</accession>
    <name>Q5CT47_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_80</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627870.1">
        <property type="nucleotide sequence ID" value="XM_627870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT47"/>
    <dbReference type="GeneID" id="3371440"/>
    <dbReference type="KEGG" id="cpv:cgd1_80"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_80"/>
    <dbReference type="InParanoid" id="Q5CT47"/>
    <dbReference type="OrthoDB" id="337898at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="147" mass="17028" checksum="B8DFA17BB0B7CB1B" modified="2005-04-12" version="1">MLINKSFILFSAVLIINIVEYILCFEKLRITPNVIEDLQNGKITLTEALDRYIVPNDIIVAYVKALSEESQKRINVDLNGVTAEVFFVGDTYYIGGIPPKPENELTIYERLRDLSDPGNPGRRWCWKFVKHAQVSYFPFSFLEEFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTB0</accession>
    <name>Q5CTB0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_3740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626559.1">
        <property type="nucleotide sequence ID" value="XM_626559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTB0"/>
    <dbReference type="GeneID" id="3373616"/>
    <dbReference type="KEGG" id="cpv:cgd2_3740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3740"/>
    <dbReference type="InParanoid" id="Q5CTB0"/>
    <dbReference type="OrthoDB" id="343342at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254944" evidence="2">
        <location>
            <begin position="21"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="351"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="453"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="462" mass="53042" checksum="25522E2C8D52D944" modified="2005-04-12" version="1">MFRNRKVLTFFLYIFYLLSGSGILGQIQKDMTEFSYNILKICKDHRRLKQEQQKLIITWIDEIFESKSVAFNVRYNLKKCKKSVRNMLDGKATMKDKIVKFFFEKRLKNYQEQCRKLATASDPLSFKKEELEELRKFTEETSSEPNSGLRLNDFYSSKFENEADSILGNSFNLGESFKSALAADQNQTSQSDEESEIVKYILPYSSYDEYLDENEIPLIEETEKFILKHDSLLLLVPKVLPMHMNYVKMPLPQIEPQPREIRIDYSTNAPESQIVAIDELFKEESESSIKSRDSVIEDEIVDEKLDIFDSSESSSGMLSESEFMDFESINIKDSIIGGKYKEKKRFKSVSVLNEPNSTDNEHISFNDKGQEAGKSESTNRTQSDKDEEVESSVGSNLSETDEESSRYEHSKSEESGSSGTDGYYETEDSTDNSQNTDDLQDQSTSESQDDSSEQSGSSGEYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTD7</accession>
    <name>Q5CTD7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="1">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_3450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626532.1">
        <property type="nucleotide sequence ID" value="XM_626532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTD7"/>
    <dbReference type="FunCoup" id="Q5CTD7">
        <property type="interactions" value="245"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTD7"/>
    <dbReference type="GeneID" id="3373697"/>
    <dbReference type="KEGG" id="cpv:cgd2_3450"/>
    <dbReference type="InParanoid" id="Q5CTD7"/>
    <dbReference type="OMA" id="KSHNFWL"/>
    <dbReference type="OrthoDB" id="292964at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02674">
        <property type="entry name" value="Peptidase_C19R"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="1" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="3">
        <location>
            <begin position="33"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="17"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="384" mass="43357" checksum="030235ADC873B1B6" modified="2005-04-12" version="1" fragment="single">SNMGNSVPSSSSSVSSETVNTNRNGAENMSSPIGIKNFGNTCYMNAGLQFISAMGIFTEENFGGIKLNKSSSEEVCRSLISILIQLGKPSRITDAISPYQLFKQLRQQNSDLFNQHQQDAHEFIMYILEIIHDGTIKPCNAPKLSNEDLEKLSKKSTRPGNVFWNNHMMRNNSILNNTICGQFRSRITCENCGNNSDTFDPFWDITLALPEVSDDYEKISIGSCFRKFFEQQNLFHENDEPNYNCSHCKSVVNATRCINISQFPNVLLVTLKRFNNNGEKCNGIVSFKTAGIILKSLTEIGHFKLVAVLQHNGSTLFQGHYISYVFKKEFNGWFKFDDDIVTLVDDILEEDIQAYCLLYILESKSALNSNSEQAYSVGIRNQRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTG0</accession>
    <name>Q5CTG0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_3160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626509.1">
        <property type="nucleotide sequence ID" value="XM_626509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTG0"/>
    <dbReference type="GeneID" id="3373559"/>
    <dbReference type="KEGG" id="cpv:cgd2_3160"/>
    <dbReference type="InParanoid" id="Q5CTG0"/>
    <dbReference type="OrthoDB" id="342201at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="140" mass="16793" checksum="E383F93D0E78F04D" modified="2005-04-12" version="1">MELLREQSLCREFIKGIDRVICMIKEIYNEKNESKDKLHMKKKIENLKIEKEYLKDILIKQMSTYCILKSLHNENKANMGNNFIIDSNENKNSIQMNNLDLEEDVMSYFDVFPQKYSISNLENTDQIPFNNKFMKERIEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTU4</accession>
    <name>Q5CTU4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nitrogen permease regulator 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_1530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NPR2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626375.1">
        <property type="nucleotide sequence ID" value="XM_626375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTU4"/>
    <dbReference type="STRING" id="353152.Q5CTU4"/>
    <dbReference type="GeneID" id="3373719"/>
    <dbReference type="KEGG" id="cpv:cgd2_1530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1530"/>
    <dbReference type="InParanoid" id="Q5CTU4"/>
    <dbReference type="OMA" id="MYVINEN"/>
    <dbReference type="OrthoDB" id="338854at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990130">
        <property type="term" value="C:GATOR1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010508">
        <property type="term" value="P:positive regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009348">
        <property type="entry name" value="NPR2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991:SF10">
        <property type="entry name" value="GATOR COMPLEX PROTEIN NPRL2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12991">
        <property type="entry name" value="NITROGEN PERMEASE REGULATOR 2/TUMOR SUPPRESSOR CANDIDATE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06218">
        <property type="entry name" value="NPR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="403" mass="46521" checksum="B5033682957E5E82" modified="2005-04-12" version="1">MNTHFSLWPKIEAIIFCKFDEELGPIVLCSSPSDIFGSEKSQLYSIITKYLLPDIHFAGKTISFVIGNRWKAIGVPIFIEGSQYLRNSFQFTVCIIVEKKPYNFYQEIYSRHIARTLGSAFKLLEEDCGILYYYCTYTENLPNLLKKVTKNNNEISSFPKNILEVIENVRSQLNKRHQVFVEFGDASILNFRIRRPPSNIIIYPEDIPFPSENTLISDIKHIGLDFSLIKILPYINGVNTSFEISRYCSLPIEDVIVCLEHLVLYGLISMIDMISSENKYRFIGGEDKHGLYRKLCNECINEGNVLSFTKKYHKELRKHKIKSIYKFIAAGVVSKKITRLHEIPIIFADTKELSGIEKELLQLCNGNSKLDHIQILLGFNTKSEIIKFISNVFDKSSIYWAYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTV6</accession>
    <name>Q5CTV6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88828.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626363.1">
        <property type="nucleotide sequence ID" value="XM_626363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTV6"/>
    <dbReference type="STRING" id="353152.Q5CTV6"/>
    <dbReference type="GeneID" id="3373730"/>
    <dbReference type="KEGG" id="cpv:cgd2_1400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1400"/>
    <dbReference type="InParanoid" id="Q5CTV6"/>
    <dbReference type="OMA" id="KSICHYW"/>
    <dbReference type="OrthoDB" id="339201at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88828.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="613" mass="70330" checksum="E1AD87844F5CFADB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTZ0</accession>
    <name>Q5CTZ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative DNA-directed RNA polymerase 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_980</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88922.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626329.1">
        <property type="nucleotide sequence ID" value="XM_626329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTZ0"/>
    <dbReference type="FunCoup" id="Q5CTZ0">
        <property type="interactions" value="546"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTZ0"/>
    <dbReference type="GeneID" id="3373684"/>
    <dbReference type="KEGG" id="cpv:cgd2_980"/>
    <dbReference type="InParanoid" id="Q5CTZ0"/>
    <dbReference type="OMA" id="VRDRGYF"/>
    <dbReference type="OrthoDB" id="248779at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.940.20:FF:000001">
        <property type="entry name" value="DNA-directed RNA polymerases I, II, and III subunit RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1340.10">
        <property type="entry name" value="RNA polymerase, Rpb5, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.20">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00025">
        <property type="entry name" value="RNApol_Rpo5_RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014381">
        <property type="entry name" value="Arch_Rpo5/euc_Rpb5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005571">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036710">
        <property type="entry name" value="RNA_pol_Rpb5_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000783">
        <property type="entry name" value="RNA_pol_subH/Rpb5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020608">
        <property type="entry name" value="RNA_pol_subH/Rpb5_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035913">
        <property type="entry name" value="RPB5-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007129">
        <property type="entry name" value="PRK09570.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10535:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01191">
        <property type="entry name" value="RNA_pol_Rpb5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03871">
        <property type="entry name" value="RNA_pol_Rpb5_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000747">
        <property type="entry name" value="RPB5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53036">
        <property type="entry name" value="Eukaryotic RPB5 N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55287">
        <property type="entry name" value="RPB5-like RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01110">
        <property type="entry name" value="RNA_POL_H_23KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase Rpb5 N-terminal" evidence="6">
        <location>
            <begin position="14"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase subunit H/Rpb5 C-terminal" evidence="5">
        <location>
            <begin position="141"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00025765"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03871"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88922.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="214" mass="25092" checksum="94EEE6448A4B9E16" modified="2005-04-12" version="1" fragment="single">DRVRCILIIMDSSDNRFFRARRTLCEMLEDRGYIVSSQDKEEDFSTFKERFESHQRLRSRMLMVASHRQDQTKRIICYFADESKKTGVKPIRDIVEKMDEHAIQRAILISQNVLTAHAKVAILDAAPKHYIESFLENELLVNITKHELVPKHILLSDDEKLQLLDRYKIKETQLPRIQYADPVARYFGLAKGQVVKIIRPSETAGRYVTYRLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU74</accession>
    <name>Q5CU74_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PUG domain fused to an UBA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_3950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88967.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626940.1">
        <property type="nucleotide sequence ID" value="XM_626940.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU74"/>
    <dbReference type="STRING" id="353152.Q5CU74"/>
    <dbReference type="GeneID" id="3373846"/>
    <dbReference type="KEGG" id="cpv:cgd3_3950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3950"/>
    <dbReference type="InParanoid" id="Q5CU74"/>
    <dbReference type="OMA" id="CANAKDH"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd10462">
        <property type="entry name" value="PUB_UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14295">
        <property type="entry name" value="UBA1_atUBP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018997">
        <property type="entry name" value="PUB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46713">
        <property type="entry name" value="F13M7.16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46713:SF1">
        <property type="entry name" value="F13M7.16 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09409">
        <property type="entry name" value="PUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22562">
        <property type="entry name" value="UBA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00580">
        <property type="entry name" value="PUG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="20"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="88"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88967.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="299" mass="35005" checksum="F7708A37DE426219" modified="2005-04-12" version="1">MTDTEKPTNISDNCDDIKNYVDKNLLNSLMEMGFGQVESEKAIFFTRNKGLENAVTWLEENSKDDSIKEPIIEISGSDSIPGAPKLTDEEALEKAKELQRRARELRIQREKEEEIEKEKRRIASTKQLLEAQRKLEEAERIRNIEKAAKEKNAHEVERQRQLSLLKEEWEERFGCPYPEEKTNEVPKGNKEKVAYYCNRMNKEYRSKDLQGIMTCFNLLKTYINNVHSHPYEEKYKRIRLKNPTFESKVLKYQGSIEILMACGFVKDNNEEFLVIPPEKIPDTFVCSQAIKFLTLLTQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUB1</accession>
    <name>Q5CUB1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Putative sodium/calcium cation exchanger having 12 transmembrane domains and signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd3_3520</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626903.1">
        <property type="nucleotide sequence ID" value="XM_626903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUB1"/>
    <dbReference type="STRING" id="353152.Q5CUB1"/>
    <dbReference type="GeneID" id="3374111"/>
    <dbReference type="KEGG" id="cpv:cgd3_3520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3520"/>
    <dbReference type="InParanoid" id="Q5CUB1"/>
    <dbReference type="OMA" id="IQWTERS"/>
    <dbReference type="OrthoDB" id="417205at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008324">
        <property type="term" value="F:monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1420.30">
        <property type="entry name" value="NCX, central ion-binding region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051359">
        <property type="entry name" value="CaCA_antiporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004837">
        <property type="entry name" value="NaCa_Exmemb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044880">
        <property type="entry name" value="NCX_ion-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266:SF0">
        <property type="entry name" value="MITOCHONDRIAL SODIUM_CALCIUM EXCHANGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12266">
        <property type="entry name" value="NA+/CA2+ K+ INDEPENDENT EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01699">
        <property type="entry name" value="Na_Ca_ex"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="3 6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254246" evidence="7">
        <location>
            <begin position="18"/>
            <end position="939"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="99"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="173"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="217"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="705"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="778"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="818"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="848"/>
            <end position="870"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="890"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="918"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="106"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="domain" description="Sodium/calcium exchanger membrane region" evidence="8">
        <location>
            <begin position="785"/>
            <end position="935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="939" mass="105358" checksum="A1B1AB3EFAD499FE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUK3</accession>
    <name>Q5CUK3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Thioredoxin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_2500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626811.1">
        <property type="nucleotide sequence ID" value="XM_626811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUK3"/>
    <dbReference type="GeneID" id="3373910"/>
    <dbReference type="KEGG" id="cpv:cgd3_2500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2500"/>
    <dbReference type="InParanoid" id="Q5CUK3"/>
    <dbReference type="OMA" id="CVTHDTF"/>
    <dbReference type="OrthoDB" id="390285at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="2">
        <location>
            <begin position="186"/>
            <end position="289"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="444" mass="52293" checksum="763BBF95553F325E" modified="2005-04-12" version="1">MFFDKRILALLMNPFRRNIKRNSFNINTFNRKCFDLFRNKDSFRFNYTIFSISISFAFLAKYYFQNTRKQLNMKAISSDEIEILSSKSKNMIVLNLIKGMEINKSNFIKELSKQIKSKELNRLNIQIYYTENNCSESAPNVTLFKGYGSRISNIDLNFKNNNIEQIKSFFDPKSEKIINGNPSTIKNISHDTFESDVINKSDENNPLLLMYYDDYCLMCFLIRPLINSLAARLRNTKNIQFGRYNIGRNDLHEFSPPVKATPSFVLFRGRQEPERLDEYKPKDIINKIIEIKCRVENNDCGKKELAELSTLEQKVLIRFHLFTVLNIWNLYLKELQAKLINTPKSQFDQLNFMHLEELLSISCLFLQDQNVSSKNSKSFDEINFEKISYDKIAENINFQEIFLENIKKDMKRSDTIEENINHLLNEIEGCCNDYIAMKKLIKNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUP1</accession>
    <name>Q5CUP1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cca1p, tRNA adenylyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_2040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626773.1">
        <property type="nucleotide sequence ID" value="XM_626773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUP1"/>
    <dbReference type="STRING" id="353152.Q5CUP1"/>
    <dbReference type="GeneID" id="3374041"/>
    <dbReference type="KEGG" id="cpv:cgd3_2040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2040"/>
    <dbReference type="InParanoid" id="Q5CUP1"/>
    <dbReference type="OMA" id="SINTIMR"/>
    <dbReference type="OrthoDB" id="445712at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052929">
        <property type="term" value="F:ATP:3'-cytidine-cytidine-tRNA adenylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052927">
        <property type="term" value="F:CC tRNA cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001680">
        <property type="term" value="P:tRNA 3'-terminal CCA addition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd05398">
        <property type="entry name" value="NT_ClassII-CCAase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.460.10">
        <property type="entry name" value="Beta Polymerase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3090.10">
        <property type="entry name" value="cca-adding enzyme, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043519">
        <property type="entry name" value="NT_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002646">
        <property type="entry name" value="PolA_pol_head_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734:SF5">
        <property type="entry name" value="CCA TRNA NUCLEOTIDYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13734">
        <property type="entry name" value="TRNA-NUCLEOTIDYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01743">
        <property type="entry name" value="PolyA_pol"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81301">
        <property type="entry name" value="Nucleotidyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81891">
        <property type="entry name" value="Poly A polymerase C-terminal region-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 4 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Poly A polymerase head" evidence="5">
        <location>
            <begin position="63"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="673" mass="78498" checksum="AB58FA3FD17BBD96" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUS0</accession>
    <name>Q5CUS0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1720</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89122.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626744.1">
        <property type="nucleotide sequence ID" value="XM_626744.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUS0"/>
    <dbReference type="STRING" id="353152.Q5CUS0"/>
    <dbReference type="GeneID" id="3374012"/>
    <dbReference type="KEGG" id="cpv:cgd3_1720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1720"/>
    <dbReference type="InParanoid" id="Q5CUS0"/>
    <dbReference type="OrthoDB" id="341943at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89122.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="272" mass="31544" checksum="9890051006323E83" modified="2005-04-12" version="1">MNMPIANSCKYAFFHYMCAYLFILTVISFLYWDGFTEILEMNQVSLFQVGIPQYQSFSEAKPLFSGKGSKEYRDFLAEFGVLDGLEIAKVRSNKALKKLLLELKQIFIKYYSLKGLVLSFKKKPSSVENQDLVENNNRMLQEANTELSKLLLEIFSCIVLKKASKYKNYTVSNNHFDCTIYSYVYYSSMKELSKRIIILLEETLSSFSKSKCSCQQFNVNVKQSPCYYLFFSVKAIKASIATETSYYCQYKRIKKNCGPYANLSLRKALSFR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUW5</accession>
    <name>Q5CUW5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">SPAC14C4.06c-like PWI+4CCCH domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd3_1230</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ZC3H14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626699.1">
        <property type="nucleotide sequence ID" value="XM_626699.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUW5"/>
    <dbReference type="FunCoup" id="Q5CUW5">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUW5"/>
    <dbReference type="GeneID" id="3373993"/>
    <dbReference type="KEGG" id="cpv:cgd3_1230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1230"/>
    <dbReference type="InParanoid" id="Q5CUW5"/>
    <dbReference type="OMA" id="NEACKLW"/>
    <dbReference type="OrthoDB" id="5589010at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043488">
        <property type="term" value="P:regulation of mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040366">
        <property type="entry name" value="Nab2/ZC3H14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14738:SF29">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 8" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="8">
        <location>
            <begin position="214"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="85"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="85"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="147"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="183"/>
            <end position="213"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008423"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="369" mass="40557" checksum="0CBDE616F8B74D11" modified="2005-04-12" version="1">MESSSGGGSSVGEVVTPEVQSKITSKLQEIFGDDDVSVLTDYICHMVNHNQPKEHIINELKEFLSDEASQFGTWVFQLVESSKNDYSTNNNMPNINHDNGLGKNNSSPNDTHKSSTQSNQNKDSLDFAISNAIKNKSGSGRSKPFQPASSHKNNHSLINHESSSGPMVGNNRLPRVNYRNAPYTRSNNFNQSGAPYNSSNQAANSSTGPSSTHGKIKIRCKNWPNCDKGDHCFYIHPSEACKSWPLCPYGPGCFFIHPTVPCRYGLACYNSLCNYSHPNGWDPNHVEAPVFKYGGYKNSSLIINNNKQSQTIGNANSNSAESNNDNSTNTISINLNQENTDMPSYDSNCNANTGHFNLESEKNNSFGHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV01</accession>
    <name>Q5CV01_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626663.1">
        <property type="nucleotide sequence ID" value="XM_626663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV01"/>
    <dbReference type="GeneID" id="3374131"/>
    <dbReference type="KEGG" id="cpv:cgd3_810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_810"/>
    <dbReference type="InParanoid" id="Q5CV01"/>
    <dbReference type="OrthoDB" id="342667at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="930"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="424"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="932"/>
            <end position="948"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="986" mass="113422" checksum="3EB0B426A3DA253B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV25</accession>
    <name>Q5CV25_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein with 12 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626639.1">
        <property type="nucleotide sequence ID" value="XM_626639.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV25"/>
    <dbReference type="GeneID" id="3373796"/>
    <dbReference type="KEGG" id="cpv:cgd3_540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_540"/>
    <dbReference type="InParanoid" id="Q5CV25"/>
    <dbReference type="OMA" id="NSERMMI"/>
    <dbReference type="OrthoDB" id="341672at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="280"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="323"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="351"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="381"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="414"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="491" mass="56284" checksum="BC2263E348CA3102" modified="2005-04-12" version="1">MMEKPFTCENQTKSGFSSTTLLLFYVVSAPMVGAPYLLPSAVKELLMNNDAYYWLDPDFKLTTMNSLCSLGTSSLLLSGVLGAYFVDLFNNRNTAILSAAFHIMGWIFCFFLDKTWFYFPYIGICLWGISTQLLTLTKTSISVFYDSKKHLVVAMVGGSVGMSFAYMQIMVNLVRYISSKGIDFHYLGINPTQFIIIINCFFSILWMIGFYFIIPKHPFVTPTVDYCTRVSISRSQIMNSLTEFDHEERLSLINSQMVVEVNRCKEDIPYQWTLTFKEQLISIPTILFTIIYSLMWFVRLYFTVNMKSILLDQTSGDLQYSESIINIFGLLLGTTFIAAILVGIFVDLMGIYLFLVLFVASSLLILVLFANFIPYCFLSHLFGIVICVFCYSYFIGCSFSLFTSAFGYTHLNSIQGISSTIAGFFTLVYNLWDSFIHRNYKDNFFFPTIIAIIINSFILILSIFILLYTKRWNSHNSTYFFSINKKTSLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV57</accession>
    <name>Q5CV57_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_5340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627412.1">
        <property type="nucleotide sequence ID" value="XM_627412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV57"/>
    <dbReference type="STRING" id="353152.Q5CV57"/>
    <dbReference type="GeneID" id="3374214"/>
    <dbReference type="KEGG" id="cpv:cgd8_5340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5340"/>
    <dbReference type="InParanoid" id="Q5CV57"/>
    <dbReference type="OMA" id="CEYCATL"/>
    <dbReference type="OrthoDB" id="342494at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253887" evidence="2">
        <location>
            <begin position="23"/>
            <end position="1138"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="630"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="818"/>
            <end position="1009"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1138" mass="127537" checksum="BD3F7EAA49229B9B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVA4</accession>
    <name>Q5CVA4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-serine/threonine phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_4810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627365.1">
        <property type="nucleotide sequence ID" value="XM_627365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVA4"/>
    <dbReference type="STRING" id="353152.Q5CVA4"/>
    <dbReference type="GeneID" id="3374354"/>
    <dbReference type="KEGG" id="cpv:cgd8_4810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4810"/>
    <dbReference type="InParanoid" id="Q5CVA4"/>
    <dbReference type="OMA" id="IINECIV"/>
    <dbReference type="OrthoDB" id="10249888at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039189">
        <property type="entry name" value="Fcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081">
        <property type="entry name" value="RNA POLYMERASE II CTD PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23081:SF36">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12738">
        <property type="entry name" value="PTCB-BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="7">
        <location>
            <begin position="225"/>
            <end position="469"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013081"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="762" mass="89824" checksum="B3B0BBA09997DED9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVE1</accession>
    <name>Q5CVE1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Transcription elongation factor TFIIS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_4400</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627328.1">
        <property type="nucleotide sequence ID" value="XM_627328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVE1"/>
    <dbReference type="STRING" id="353152.Q5CVE1"/>
    <dbReference type="GeneID" id="3374533"/>
    <dbReference type="KEGG" id="cpv:cgd8_4400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4400"/>
    <dbReference type="InParanoid" id="Q5CVE1"/>
    <dbReference type="OMA" id="RFVVMTH"/>
    <dbReference type="OrthoDB" id="44867at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13749">
        <property type="entry name" value="Zn-ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.930.10">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035100">
        <property type="entry name" value="TF_IIS-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035441">
        <property type="entry name" value="TFIIS/LEDGF_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017923">
        <property type="entry name" value="TFIIS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001222">
        <property type="entry name" value="Znf_TFIIS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477:SF0">
        <property type="entry name" value="IP08861P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11477">
        <property type="entry name" value="TRANSCRIPTION FACTOR S-II ZINC FINGER DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08711">
        <property type="entry name" value="Med26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01096">
        <property type="entry name" value="Zn_ribbon_TFIIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006704">
        <property type="entry name" value="TF_IIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00510">
        <property type="entry name" value="TFS2M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00440">
        <property type="entry name" value="ZnF_C2C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47676">
        <property type="entry name" value="Conserved domain common to transcription factors TFIIS, elongin A, CRSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51319">
        <property type="entry name" value="TFIIS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00466">
        <property type="entry name" value="ZF_TFIIS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51133">
        <property type="entry name" value="ZF_TFIIS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIS N-terminal" evidence="9">
        <location>
            <begin position="12"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS central" evidence="10">
        <location>
            <begin position="161"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="TFIIS-type" evidence="8">
        <location>
            <begin position="291"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="94"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00472"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00649"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="332" mass="38400" checksum="EAC621A9B66D4650" modified="2005-04-12" version="1">MSDSKDIILEIKLMKESLERLILNKESESTYDEVMKILEKLESVCINREILKQTKIGVVMTAVKKGFCTVNNIAIVTKADELIRKWKDSLATNTQQAPNNNEKLNDQNVSSTAKKLKQSAENKTKDIQESQNQVKNETKEEIKEEEILHKEYTGPLTGDVMRDKARHFLWKAMVTGVPYSQAKLMKESQVCEIAAEIESVLHREYIVKGDNSVRDYNLQLKTIKWNLSDLKNPELNSKLYVGKITPEEIARMQSREMASDAKQKEREKHKQESLEACQSDWDLRNLIQKEGQFTCGKCKTNKTTYYQMQTRSADEPMTTFVRCLNCGNRWKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVF2</accession>
    <name>Q5CVF2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Zz domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_4280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the KRI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627317.1">
        <property type="nucleotide sequence ID" value="XM_627317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVF2"/>
    <dbReference type="FunCoup" id="Q5CVF2">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVF2"/>
    <dbReference type="GeneID" id="3374631"/>
    <dbReference type="KEGG" id="cpv:cgd8_4280"/>
    <dbReference type="InParanoid" id="Q5CVF2"/>
    <dbReference type="OMA" id="WDNYDPR"/>
    <dbReference type="OrthoDB" id="10252032at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02249">
        <property type="entry name" value="ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018034">
        <property type="entry name" value="Kri1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024626">
        <property type="entry name" value="Kri1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490:SF5">
        <property type="entry name" value="PROTEIN KRI1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14490">
        <property type="entry name" value="ZINC FINGER, ZZ TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05178">
        <property type="entry name" value="Kri1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12936">
        <property type="entry name" value="Kri1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Kri1-like C-terminal" evidence="7">
        <location>
            <begin position="561"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="38"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="106"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="628"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="333"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="38"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="58"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="116"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="129"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="650"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="663"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="685" mass="80601" checksum="6CBD08037D8238E4" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVI4</accession>
    <name>Q5CVI4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">LepA like TRAFAC class GTpase, 2 transmembrane domain near C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_3930</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627285.1">
        <property type="nucleotide sequence ID" value="XM_627285.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVI4"/>
    <dbReference type="STRING" id="353152.Q5CVI4"/>
    <dbReference type="GeneID" id="3374589"/>
    <dbReference type="KEGG" id="cpv:cgd8_3930"/>
    <dbReference type="InParanoid" id="Q5CVI4"/>
    <dbReference type="OMA" id="YEFETNH"/>
    <dbReference type="OrthoDB" id="1716625at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027094">
        <property type="entry name" value="Mitofusin_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465:SF4">
        <property type="entry name" value="DYNAMIN N-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10465">
        <property type="entry name" value="TRANSMEMBRANE GTPASE FZO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="373"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="419"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="G" evidence="8">
        <location>
            <begin position="57"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="8"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="478" mass="53493" checksum="B9B26FFEEF44422F" modified="2005-04-12" version="1">MGRKGGKSRNLDRFINQYEDEMEGYEEELENNDDGLGLYSISRALNLKVSKLGRKATVMIIGNVSAGKSTLINWLLQENIQKTGMAIETCGISFVVSGKQVNEIGGETALMILPELREVVERNPTLLPSLSVKTFPSNQGRLQSINFIDTPGLLDGDSIYSFDIDNVIRDIAMSLCDLVLICIDPSGQALSKRLLSFAKYIAQNAPRKTSFLLTKIDEIPTEEDRIKVICQVTQNLSSSIAIKHGFDLIPIYIAGAKDGTYLTLNTLQSLGESFSNSENQNITNVRTKSGKSHAPDKLSQVGNGLPTLNRILEVVDQIEKVVDRKVQDDIATLLNDCQTLLEHNKCLIYKQTQLEKNKENLYRQKNLYKKSSLFIILLMLIMAIFQVCNYSGFNIFSNSEAIQQNGTAASFDLTPENQISVWLFLTASLLTSLLLYRNVQKEQQQCFHRSLKTLKKYLSVLNSINSKAVDLHDSYINI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVI5</accession>
    <name>Q5CVI5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">PIR protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3920</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627284.1">
        <property type="nucleotide sequence ID" value="XM_627284.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVI5"/>
    <dbReference type="GeneID" id="3374260"/>
    <dbReference type="KEGG" id="cpv:cgd8_3920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3920"/>
    <dbReference type="InParanoid" id="Q5CVI5"/>
    <dbReference type="OMA" id="FVLWILI"/>
    <dbReference type="OrthoDB" id="337412at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253899" description="PIR protein" evidence="2">
        <location>
            <begin position="30"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="205"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="244" mass="28472" checksum="D93E1166F43C3169" modified="2005-04-12" version="1">MPISIRRYLNINSFILILVISIFFSSLDAAKKVIENKYDGNKQKEESLSPGINQPIENSQGESLALFEAYTKSLKFVLEGMFGPEYSQIISNKKNYENLPLCRENEQMVNKGCNVMMYSCSKHKNGKFSCYFYYWSFCQCSKPWKLKFLNYFIPPLYDCYPSVATEEDFSLALTSQNEEKIPLEKEFSKISEDLEIPVGICGTNVVFVIWILLVSSFFTWVIYRIYKFGCYIKNQITLSNRKRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVL0</accession>
    <name>Q5CVL0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627259.1">
        <property type="nucleotide sequence ID" value="XM_627259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVL0"/>
    <dbReference type="GeneID" id="3374309"/>
    <dbReference type="KEGG" id="cpv:cgd8_3670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3670"/>
    <dbReference type="InParanoid" id="Q5CVL0"/>
    <dbReference type="OrthoDB" id="338362at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="29"/>
            <end position="48"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="224" mass="26036" checksum="B144AA983981EB79" modified="2005-04-12" version="1">MHAIIISCVRQFAYGKIIELYKYLNSFRLFMKMPSFISTIYILIGLLMKIEISYSKFEFLRRDHAYKNEIFEKNNQSISQNKENLHHYLPIFNFSEEFVAPNRTYQFLELYKEISTIKSANSVSLKKAYVDQVLIPKTDAKVAKLKAETAYIETKNAAKKKKMSQVKGDFEKNITFSSLIGNLLNSSSQINGTQILNNIYNETFYYLNNKNMSNSTEGIVYELA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVY5</accession>
    <name>Q5CVY5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627134.1">
        <property type="nucleotide sequence ID" value="XM_627134.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVY5"/>
    <dbReference type="GeneID" id="3374457"/>
    <dbReference type="KEGG" id="cpv:cgd8_2310"/>
    <dbReference type="InParanoid" id="Q5CVY5"/>
    <dbReference type="OMA" id="RYASKCL"/>
    <dbReference type="OrthoDB" id="341670at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="148" mass="17301" checksum="840A5B33A6039384" modified="2005-04-12" version="1">MFETVVLVAIFTIVFTGLIMAGYIQYYENAPIEDIRKLLKESYIILALMELLFGLFGIISFKVEIVLQFLDWWLFYQASNKYPYIFSMDSFFPVKVIIVTLIKAIISIRTSFNIPFRSLIFPYIMSTVCILPLLFAFSYPYEDSVSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="127" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW06</accession>
    <name>Q5CW06_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Cation-transporting ATPase</fullName>
            <ecNumber evidence="13">7.2.2.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">cgd8_2090</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 13">Membrane</location>
            <topology evidence="1 13">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.-" evidence="13"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627113.1">
        <property type="nucleotide sequence ID" value="XM_627113.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CW06">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW06"/>
    <dbReference type="TCDB" id="3.A.3.10.14">
        <property type="family name" value="the p-type atpase (p-atpase) superfamily"/>
    </dbReference>
    <dbReference type="GeneID" id="3374500"/>
    <dbReference type="KEGG" id="cpv:cgd8_2090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2090"/>
    <dbReference type="InParanoid" id="Q5CW06"/>
    <dbReference type="OMA" id="FSCFQYM"/>
    <dbReference type="OrthoDB" id="425043at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140358">
        <property type="term" value="F:P-type transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047819">
        <property type="entry name" value="P5A-ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF8">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12409">
        <property type="entry name" value="P5-ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 13" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 13 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="62"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="307"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="487"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1241"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1309"/>
            <end position="1331"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1363"/>
            <end position="1382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1394"/>
            <end position="1412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="1432"/>
            <end position="1453"/>
        </location>
    </feature>
    <feature type="domain" description="P5B-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="50"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="15">
        <location>
            <begin position="356"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="703"/>
            <end position="722"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF12409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAK89407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1491" mass="168793" checksum="6D8C2E566B15C1FC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW27</accession>
    <name>Q5CW27_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Vps9p/ RAB5 like RAB GTpase binding protein involved in vacuolar sorting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_1880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627092.1">
        <property type="nucleotide sequence ID" value="XM_627092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW27"/>
    <dbReference type="STRING" id="353152.Q5CW27"/>
    <dbReference type="GeneID" id="3374509"/>
    <dbReference type="KEGG" id="cpv:cgd8_1880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1880"/>
    <dbReference type="InParanoid" id="Q5CW27"/>
    <dbReference type="OMA" id="VFNMDAH"/>
    <dbReference type="OrthoDB" id="300289at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030139">
        <property type="term" value="C:endocytic vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.80">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003123">
        <property type="entry name" value="VPS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045046">
        <property type="entry name" value="Vps9-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037191">
        <property type="entry name" value="VPS9_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101:SF25">
        <property type="entry name" value="GTPASE-ACTIVATING PROTEIN AND VPS9 DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23101">
        <property type="entry name" value="RAB GDP/GTP EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02204">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00167">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109993">
        <property type="entry name" value="VPS9 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51205">
        <property type="entry name" value="VPS9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="VPS9" evidence="3">
        <location>
            <begin position="208"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="406"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="463" mass="53199" checksum="8B0785F3AC65CBF2" modified="2005-04-12" version="1">MNDVNKKETKSMEYSDSVTGSPNDFCRADLDGVDYNNESPGLGVNIGNSREFVNSGTCEGLEIKVDGEKNNSSSSTDNQQTKNVAPYNRFLILLKDKTCSDIVFFIAKFIQHYPRLDEGLVDLIYGESRERFDLEEIINGNEDIGTQVLANILHSFVGFCGNLLMETKVFNKVGNEEEEKIFIIEGLEKLVTTKLYNVLFDAVSFENDDADHYLFRKLKVLKTFVKLDHFDISKHYVETLQSDSLWLDICKNELYKLIRVKSPKDKVVLIVNICKILLSYMNNINKMRLETDSNSGEERISSPPAADDLLPLLIFCIIQSNPTKIKAHVEFVSLFRNSILLVSEDLYFFTHFYSAITFLEKLDGRQIQLNIDNVIFEEQFKSSEKKLFGNNLLHLLTPYSESRLSFQEKQNKLQEITNKLSSLKLTFEDYNSSDELKIGEIPQLFQEYKQLLNLFKELKQNSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW95</accession>
    <name>Q5CW95_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Amino acid permease like integral membrane protein, signal peptide plus 11 transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_1170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627024.1">
        <property type="nucleotide sequence ID" value="XM_627024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW95"/>
    <dbReference type="SMR" id="Q5CW95"/>
    <dbReference type="FunCoup" id="Q5CW95">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW95"/>
    <dbReference type="GeneID" id="3374568"/>
    <dbReference type="KEGG" id="cpv:cgd8_1170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1170"/>
    <dbReference type="InParanoid" id="Q5CW95"/>
    <dbReference type="OMA" id="FAYICHY"/>
    <dbReference type="OrthoDB" id="28208at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="217"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="251"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="376"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="440"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="6"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="462" mass="51339" checksum="A0DF6FAF7A797E81" modified="2005-04-12" version="1">MFSHEKSSMLTTILIVVATSVGVGCFYIPAAFKNCGAMAGLIISLIVGTFSVLSMKTLANASVKSGAESYGSLLFMAYSEEITTSLRIQRSENPFFSIPRLFDFLVFLDCLFCIPLFLIVLSDLIPALISYFGFVNDYLFMFSSKTAIISLFSLLFFPICIPSGCFNWIGLTFLSVISIFLCFASVISQSISSGFGINNIIKEISNISFNSNSISSYFSLLNICIFAFFAQFNIIQAASNLNNPSKSRLRILTAVTGIIIVFTYSIMSLISFSFLGDRTEEFLLNSLTDTSYLFFISRLLVVVSLFFIIPLHIYPMLDALTNFIDNDYLNEMLGSRNVQSGFNEQGMPLINNGNNVIASGTINKKTTFIRTKTGRISLLTLILFLSCIIGICFQNKPSSLVIMAGGFVDSIFVFLFPALIHHRVIYNKKEKFTSSPVRLLFSLFFIISVLGSVNSLLKLFYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWI5</accession>
    <name>Q5CWI5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_4940</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627819.1">
        <property type="nucleotide sequence ID" value="XM_627819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWI5"/>
    <dbReference type="GeneID" id="3375817"/>
    <dbReference type="KEGG" id="cpv:cgd6_4940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4940"/>
    <dbReference type="InParanoid" id="Q5CWI5"/>
    <dbReference type="OMA" id="QIEVWNE"/>
    <dbReference type="OrthoDB" id="338152at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="364"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="399"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="452" mass="54065" checksum="4A996F884702951F" modified="2007-04-03" version="1">MNRDLGEYFAIMGIKDCEYYSLEEVLERVKTSNIRFNRDVMRNVFLSIKPTHIDKCSGKQIKDNYLKRRWELQTMLDTCFREFEALEQLRQQAENNLRRYENVASKYDQEESKLMIQVVSLDLQKEMNLEVGYKVHLECQDQVIETQWKRYQHDKKCVFWNELFSFEIERKFATEANILDIILLDSRSNLQLGGCNVILDELADQRKHELRKEIYSNTDEVVIGSLLISCQWLYSRHILYKSYVREFKQKRDQKMEDLNTYQNELACLDEPFLPKSNNLSLYSYLSSVPDYLANKLDNSLTQFKINGPEVLYKYVIFISFLLQWIASATRSCYLDSLTTCYIFWCNLGNEGFASSRWTNNGFKFILYSIFISLIIDIFWMNIFFPAWSVSSEEGDLRNFSKVFTFFNFVWKIILFFIIWKSRNDFIKFQQYDEALLRKNKHGNLSLQNHLNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWJ3</accession>
    <name>Q5CWJ3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">subtilisin</fullName>
            <ecNumber evidence="7">3.4.21.62</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd6_4840</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides.</text>
            <dbReference type="EC" id="3.4.21.62"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 8 9">Belongs to the peptidase S8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.62" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627811.1">
        <property type="nucleotide sequence ID" value="XM_627811.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWJ3"/>
    <dbReference type="STRING" id="353152.Q5CWJ3"/>
    <dbReference type="GeneID" id="3375811"/>
    <dbReference type="KEGG" id="cpv:cgd6_4840"/>
    <dbReference type="InParanoid" id="Q5CWJ3"/>
    <dbReference type="OMA" id="MWINQKE"/>
    <dbReference type="OrthoDB" id="531541at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007160">
        <property type="term" value="P:cell-matrix adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07473">
        <property type="entry name" value="Peptidases_S8_Subtilisin_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.200">
        <property type="entry name" value="Peptidase S8/S53 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003886">
        <property type="entry name" value="NIDO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000209">
        <property type="entry name" value="Peptidase_S8/S53_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036852">
        <property type="entry name" value="Peptidase_S8/S53_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051048">
        <property type="entry name" value="Peptidase_S8/S53_subtilisin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023827">
        <property type="entry name" value="Peptidase_S8_Asp-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022398">
        <property type="entry name" value="Peptidase_S8_His-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023828">
        <property type="entry name" value="Peptidase_S8_Ser-AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015500">
        <property type="entry name" value="Peptidase_S8_subtilisin-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034204">
        <property type="entry name" value="PfSUB1-like_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399:SF4">
        <property type="entry name" value="CELL WALL-ASSOCIATED PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43399">
        <property type="entry name" value="SUBTILISIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06119">
        <property type="entry name" value="NIDO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00082">
        <property type="entry name" value="Peptidase_S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00723">
        <property type="entry name" value="SUBTILISIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52743">
        <property type="entry name" value="Subtilisin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51892">
        <property type="entry name" value="SUBTILASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00136">
        <property type="entry name" value="SUBTILASE_ASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00137">
        <property type="entry name" value="SUBTILASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00138">
        <property type="entry name" value="SUBTILASE_SER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 8 9" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5" id="KW-0865">Zymogen</keyword>
    <feature type="domain" description="Peptidase S8/S53" evidence="11">
        <location>
            <begin position="302"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="domain" description="NIDO" evidence="12">
        <location>
            <begin position="1012"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="894"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="899"/>
            <end position="909"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="310"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="366"/>
        </location>
    </feature>
    <feature type="active site" description="Charge relay system" evidence="8">
        <location>
            <position position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011073"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023619"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003355"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF06119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK90066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1197" mass="132940" checksum="0157CD5F7285D356" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWT5</accession>
    <name>Q5CWT5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Phosphotransferase</fullName>
            <ecNumber evidence="11">2.7.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd6_3800</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-fructose + ATP = D-fructose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16125"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37721"/>
            <dbReference type="ChEBI" id="CHEBI:61527"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:16126"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>a D-hexose + ATP = a D-hexose 6-phosphate + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:22740"/>
            <dbReference type="ChEBI" id="CHEBI:4194"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:229467"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:22741"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 1/4.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate metabolism; hexose metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the hexokinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.-" evidence="11"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89990.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627719.1">
        <property type="nucleotide sequence ID" value="XM_627719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWT5"/>
    <dbReference type="FunCoup" id="Q5CWT5">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWT5"/>
    <dbReference type="GeneID" id="3375735"/>
    <dbReference type="KEGG" id="cpv:cgd6_3800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3800"/>
    <dbReference type="InParanoid" id="Q5CWT5"/>
    <dbReference type="OMA" id="ADCVQQF"/>
    <dbReference type="OrthoDB" id="419537at2759"/>
    <dbReference type="BRENDA" id="2.7.1.1">
        <property type="organism ID" value="1728"/>
    </dbReference>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00180"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005536">
        <property type="term" value="F:D-glucose binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008865">
        <property type="term" value="F:fructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004340">
        <property type="term" value="F:glucokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001678">
        <property type="term" value="P:intracellular glucose homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd24000">
        <property type="entry name" value="ASKHA_NBD_HK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.367.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001312">
        <property type="entry name" value="Hexokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022673">
        <property type="entry name" value="Hexokinase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022672">
        <property type="entry name" value="Hexokinase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443">
        <property type="entry name" value="HEXOKINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19443:SF16">
        <property type="entry name" value="HEXOKINASE TYPE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00349">
        <property type="entry name" value="Hexokinase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03727">
        <property type="entry name" value="Hexokinase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00475">
        <property type="entry name" value="HEXOKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51748">
        <property type="entry name" value="HEXOKINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 11 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Hexokinase N-terminal" evidence="12">
        <location>
            <begin position="14"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="domain" description="Hexokinase C-terminal" evidence="13">
        <location>
            <begin position="282"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004888"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047905"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU362007"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF03727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK89990.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="518" mass="58457" checksum="949B769F3E6505A2" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWU2</accession>
    <name>Q5CWU2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Pyrroline-5-carboxylate reductase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_3720</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pyrroline-5-carboxylate reductase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627712.1">
        <property type="nucleotide sequence ID" value="XM_627712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWU2"/>
    <dbReference type="FunCoup" id="Q5CWU2">
        <property type="interactions" value="91"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWU2"/>
    <dbReference type="GeneID" id="3375900"/>
    <dbReference type="KEGG" id="cpv:cgd6_3720"/>
    <dbReference type="InParanoid" id="Q5CWU2"/>
    <dbReference type="OMA" id="VWAVKPQ"/>
    <dbReference type="OrthoDB" id="10263291at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004735">
        <property type="term" value="F:pyrroline-5-carboxylate reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055129">
        <property type="term" value="P:L-proline biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3730.10">
        <property type="entry name" value="ProC C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01925">
        <property type="entry name" value="P5C_reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008927">
        <property type="entry name" value="6-PGluconate_DH-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028939">
        <property type="entry name" value="P5C_Rdtase_cat_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029036">
        <property type="entry name" value="P5CR_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000304">
        <property type="entry name" value="Pyrroline-COOH_reductase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11645:SF0">
        <property type="entry name" value="PYRROLINE-5-CARBOXYLATE REDUCTASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03807">
        <property type="entry name" value="F420_oxidored"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14748">
        <property type="entry name" value="P5CR_dimer"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000193">
        <property type="entry name" value="Pyrrol-5-carb_rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48179">
        <property type="entry name" value="6-phosphogluconate dehydrogenase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase catalytic N-terminal" evidence="4">
        <location>
            <begin position="4"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="Pyrroline-5-carboxylate reductase dimerisation" evidence="5">
        <location>
            <begin position="174"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF14748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="281" mass="31159" checksum="D0872525ABD26D86" modified="2005-04-12" version="1" fragment="single">KQYLGFIGCGNIANAIISGFLSSEKIKSDQIFLFDSNKNSLESLKREFSGINISENFQSLVGNSELIFICVKPHILSQILSEINNLNIESDLKSGDKVLISVCAGKTISDILKEFQSNEIHCIRVMPNLTLSICQGTWLYYENPVAHFTKYKQNNSNEIIEILSSCGTVYKINEDIFSHCTSISGCGPGYFSNIAHHFIQSGIKIGIPEDLARKLVIETMYGTSKLLFESSIDPQVFQSKVSTPGGSTQAGIDILEDRLIGKIFQDCLYSSLDRCNQLSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWY1</accession>
    <name>Q5CWY1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">1,4-alpha-glucan branching enzyme</fullName>
            <ecNumber evidence="4">2.4.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_3280</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Transfers a segment of a (1-&gt;4)-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain.</text>
            <dbReference type="EC" id="2.4.1.18"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Glycan biosynthesis; glycogen biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.18" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89954.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627673.1">
        <property type="nucleotide sequence ID" value="XM_627673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWY1"/>
    <dbReference type="STRING" id="353152.Q5CWY1"/>
    <dbReference type="GeneID" id="3375699"/>
    <dbReference type="KEGG" id="cpv:cgd6_3280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3280"/>
    <dbReference type="InParanoid" id="Q5CWY1"/>
    <dbReference type="OMA" id="ERYKFEI"/>
    <dbReference type="OrthoDB" id="5590356at2759"/>
    <dbReference type="UniPathway" id="UPA00164"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043169">
        <property type="term" value="F:cation binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005978">
        <property type="term" value="P:glycogen biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd11322">
        <property type="entry name" value="AmyAc_Glg_BE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02855">
        <property type="entry name" value="E_set_GBE_prok_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006048">
        <property type="entry name" value="A-amylase/branching_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006407">
        <property type="entry name" value="GlgB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044143">
        <property type="entry name" value="GlgB_N_E_set_prok"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004193">
        <property type="entry name" value="Glyco_hydro_13_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01515">
        <property type="entry name" value="branching_enzym"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003811">
        <property type="entry name" value="PRK05402.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF008967">
        <property type="entry name" value="PRK12313.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02806">
        <property type="entry name" value="Alpha-amylase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02922">
        <property type="entry name" value="CBM_48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="7" id="KW-0320">Glycogen biosynthesis</keyword>
    <keyword evidence="5" id="KW-0321">Glycogen metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="10">
        <location>
            <begin position="542"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="51"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="298"/>
            <end position="308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000826"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89954.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1030" mass="118357" checksum="1F05A332F01FFC99" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX08</accession>
    <name>Q5CX08_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Folate receptor-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_2980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89931.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627646.1">
        <property type="nucleotide sequence ID" value="XM_627646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX08"/>
    <dbReference type="STRING" id="353152.Q5CX08"/>
    <dbReference type="GeneID" id="3375676"/>
    <dbReference type="KEGG" id="cpv:cgd6_2980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2980"/>
    <dbReference type="InParanoid" id="Q5CX08"/>
    <dbReference type="OMA" id="CYQNDVL"/>
    <dbReference type="OrthoDB" id="342101at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053305">
        <property type="entry name" value="Folate-binding_rcpt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018143">
        <property type="entry name" value="Folate_rcpt-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37390:SF1">
        <property type="entry name" value="FOLATE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37390">
        <property type="entry name" value="OS02G0592500 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03024">
        <property type="entry name" value="Folate_rec"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="271"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="domain" description="Folate receptor-like" evidence="4">
        <location>
            <begin position="40"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89931.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="295" mass="34005" checksum="F6F0C2FA62AF27EE" modified="2007-04-03" version="1">MQKSLSIHKHKMVLKLLLTSLLGLLNIIVWANGEEREPFCLEIYDNKNDEKHLPYYFLNEFPICKEHERRTCCKKSHSEAISRLFSTLVARSSLSTRCSNFYQKSLCSYCDADIGVGKKVIQKSPILCQSYCNLWYDACYEDYFDNIQNSYIRNIEDISFIRLNLIPCTDSSAICSPLHAITLDPTEFCSLNGFSTHQDFHSSSGPASLTEYNTECFNGIPAASVLKPGIRQKTQSYKYKRSQYSKKPKAKNKFYQIIQDHINVFLENVKVPLPVIVFISIISIWIINQVINFFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX36</accession>
    <name>Q5CX36_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">DNA repair helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd6_2660</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627618.1">
        <property type="nucleotide sequence ID" value="XM_627618.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX36"/>
    <dbReference type="FunCoup" id="Q5CX36">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX36"/>
    <dbReference type="GeneID" id="3375888"/>
    <dbReference type="KEGG" id="cpv:cgd6_2660"/>
    <dbReference type="InParanoid" id="Q5CX36"/>
    <dbReference type="OMA" id="NCATIVA"/>
    <dbReference type="OrthoDB" id="19182at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070182">
        <property type="term" value="F:DNA polymerase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016818">
        <property type="term" value="F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045910">
        <property type="term" value="P:negative regulation of DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904430">
        <property type="term" value="P:negative regulation of t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010569">
        <property type="term" value="P:regulation of double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090657">
        <property type="term" value="P:telomeric loop disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18788">
        <property type="entry name" value="SF2_C_XPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006555">
        <property type="entry name" value="ATP-dep_Helicase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045028">
        <property type="entry name" value="DinG/Rad3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014013">
        <property type="entry name" value="Helic_SF1/SF2_ATP-bd_DinG/Rad3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006554">
        <property type="entry name" value="Helicase-like_DEXD_c2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010614">
        <property type="entry name" value="RAD3-like_helicase_DEAD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057498">
        <property type="entry name" value="Rtel1_ARCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472">
        <property type="entry name" value="DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11472:SF34">
        <property type="entry name" value="REGULATOR OF TELOMERE ELONGATION HELICASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23109">
        <property type="entry name" value="ARCH_RTEL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06733">
        <property type="entry name" value="DEAD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13307">
        <property type="entry name" value="Helicase_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00488">
        <property type="entry name" value="DEXDc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00491">
        <property type="entry name" value="HELICc2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51193">
        <property type="entry name" value="HELICASE_ATP_BIND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="11" id="KW-0234">DNA repair</keyword>
    <keyword evidence="10" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="12" id="KW-0413">Isomerase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="19"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="923"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="964"/>
            <end position="990"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="923"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="964"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK90143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1108" mass="124400" checksum="31EC6065E5E19F20" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX91</accession>
    <name>Q5CX91_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Transmembrane protein with 6 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_2030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627563.1">
        <property type="nucleotide sequence ID" value="XM_627563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX91"/>
    <dbReference type="STRING" id="353152.Q5CX91"/>
    <dbReference type="GeneID" id="3375873"/>
    <dbReference type="KEGG" id="cpv:cgd6_2030"/>
    <dbReference type="InParanoid" id="Q5CX91"/>
    <dbReference type="OMA" id="KQIFMIN"/>
    <dbReference type="OrthoDB" id="754047at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF0">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="90"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="129"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="193"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="301" mass="33260" checksum="1A0A2D00A65CB2D6" modified="2005-04-12" version="1" fragment="single">SLKKQALVVETSGINGGAETVSDYFGSKALGALATAYFSGSLLDTYSKQGIFLTTSIFPLFVFIACLIMDDKKQTEDLTAKNQLFSLKEFLKKPIIWGPAIYIFTYTAGPDYDDAMFFYFTNRLGFSPTFMGSLRLTYGIAGIIGIVLYRIILKKTPFREILLWTTLFSIPIYILPLALVTGLNLNMGISNRMFALSGGFLIEAIAEIQLLPLLVMTAKFCPKGLEGSVYAVMMSIRSLGIGVSKVISAGLAYSLGITAFNFSNLGLLIWISSAFLLLPLFFLNLVSYHTFSIFQVHFFRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX95</accession>
    <name>Q5CX95_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_1980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627559.1">
        <property type="nucleotide sequence ID" value="XM_627559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX95"/>
    <dbReference type="GeneID" id="3376070"/>
    <dbReference type="KEGG" id="cpv:cgd6_1980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1980"/>
    <dbReference type="InParanoid" id="Q5CX95"/>
    <dbReference type="OMA" id="ETLVACY"/>
    <dbReference type="OrthoDB" id="341962at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253937" evidence="2">
        <location>
            <begin position="20"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="166"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="206" mass="23506" checksum="B3F180EC3C669D55" modified="2007-04-03" version="1">MKHTKYLLLLLTPTFLVYCSNITPKLENDTFIDALDKDLSENEKEKKMTVCFELTQKEFIEKRDVYQKIAASIKDKESITSNDALRALFHQNLITCYFNSNIKDINSVINRNIPKEGIAKMFTVSENTPLRFSSNQLKILERVISMSTKNTGKQISGGIAKQLSGFYGHLYFIFALLLIGVSFYFALDRLNKSIKGAKGKITKKNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXB5</accession>
    <name>Q5CXB5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cleavage and polyadenylation specificity factor 4-like 3x Zn C3H1 domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_1730</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627539.1">
        <property type="nucleotide sequence ID" value="XM_627539.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXB5"/>
    <dbReference type="STRING" id="353152.Q5CXB5"/>
    <dbReference type="GeneID" id="3376120"/>
    <dbReference type="KEGG" id="cpv:cgd6_1730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1730"/>
    <dbReference type="InParanoid" id="Q5CXB5"/>
    <dbReference type="OMA" id="QYDYERM"/>
    <dbReference type="OrthoDB" id="1914176at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045348">
        <property type="entry name" value="CPSF4/Yth1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102:SF24">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23102">
        <property type="entry name" value="CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 9" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="10">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="9">
        <location>
            <begin position="93"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="178" mass="20776" checksum="C0912E17CA75587A" modified="2007-04-03" version="1">MSARLSIEDVIERMEDEKLRLLQNQSVTRYDPNVRGRHSVVCRHWIRNMCMKGDFCDFLHQYNYERMPPCFIYQKYGVCVDEALGNCPFKHKADDTPLCAQYFLGFCKYGPKCKRRHEPKARHEIPDFLPDSFLLSIIQDKNLIPKMDPETSSIIKVLDDICKESYAQAVCSEVSSNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXN1</accession>
    <name>Q5CXN1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pre-mRNA polyadenylation factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the FIP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89745.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627423.1">
        <property type="nucleotide sequence ID" value="XM_627423.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXN1"/>
    <dbReference type="STRING" id="353152.Q5CXN1"/>
    <dbReference type="GeneID" id="3376102"/>
    <dbReference type="KEGG" id="cpv:cgd6_400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_400"/>
    <dbReference type="InParanoid" id="Q5CXN1"/>
    <dbReference type="OMA" id="MLEIHDN"/>
    <dbReference type="OrthoDB" id="1917198at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007854">
        <property type="entry name" value="Fip1_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05182">
        <property type="entry name" value="Fip1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Pre-mRNA polyadenylation factor Fip1" evidence="6">
        <location>
            <begin position="148"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="78"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="302"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="87"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="307"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007459"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF05182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89745.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="327" mass="36436" checksum="65AD1E9B3E6C4E9C" modified="2005-04-12" version="1">MSGSNLEDNISKNNNGTKNEDYDENDNEDDDEDITFLICGGNEEGGLKDFSKLNDKISSTGGDNEVDNSINPASDVLKKGMTDCKPGNTGASNGNSSNINNQKMNTGDQNLHALNVSNTIYIDNEDTATEENPCKNLQMVWDNNPELRPWSRLLDVSPWFNYGFTEKTFKEYIIRQLGIRWERIKKQNIETSDDLLNKSTITSGISNSNNVNANLNINNSNTGLPNPNIKMMNNLPPPPPITGFPSNMIYFPPPPPPHLNPPIPGHPNIYHQQHMFNNFPHHIPHHSHIPPPIPSHQIMHHPGLPPNNMNPGANTAFNARSKKRPAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXP1</accession>
    <name>Q5CXP1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">VPS16 vacuolar sorting protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_5460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628689.1">
        <property type="nucleotide sequence ID" value="XM_628687.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXP1"/>
    <dbReference type="FunCoup" id="Q5CXP1">
        <property type="interactions" value="470"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXP1"/>
    <dbReference type="GeneID" id="3372154"/>
    <dbReference type="KEGG" id="cpv:cgd7_5460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5460"/>
    <dbReference type="InParanoid" id="Q5CXP1"/>
    <dbReference type="OMA" id="WCGDDCL"/>
    <dbReference type="OrthoDB" id="1792at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042144">
        <property type="term" value="P:vacuole fusion, non-autophagic"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.780">
        <property type="entry name" value="Vps16, C-terminal region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016534">
        <property type="entry name" value="VPS16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006925">
        <property type="entry name" value="Vps16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038132">
        <property type="entry name" value="Vps16_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006926">
        <property type="entry name" value="Vps16_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12811:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 16 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04840">
        <property type="entry name" value="Vps16_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04841">
        <property type="entry name" value="Vps16_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007949">
        <property type="entry name" value="VPS16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps16 N-terminal" evidence="3">
        <location>
            <begin position="3"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="2">
        <location>
            <begin position="570"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="domain" description="Vps16 C-terminal" evidence="2">
        <location>
            <begin position="760"/>
            <end position="941"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="966" mass="108288" checksum="72F5C35A34CDBE8A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXR7</accession>
    <name>Q5CXR7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">2-phosphoglycerate kinase involved in 2,3 diphosphoglycerate synthesis (P-loop kinase, distorted P-loop)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_5200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628663.1">
        <property type="nucleotide sequence ID" value="XM_628661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXR7"/>
    <dbReference type="GeneID" id="3372094"/>
    <dbReference type="KEGG" id="cpv:cgd7_5200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5200"/>
    <dbReference type="InParanoid" id="Q5CXR7"/>
    <dbReference type="OMA" id="ICYKSTI"/>
    <dbReference type="OrthoDB" id="271259at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0418">Kinase</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="290" mass="33225" checksum="3745E25196C82466" modified="2005-04-12" version="1">MLTLNTFNIRRLLLTCQVYDNDQIDKILDTLSEINVDEYKDEFLDMLAKNTLLIINRDISKEIKVMKEMFTSKLAIVPLIFGIQGSNKSSVIIDLSHYLNIPNVVSTNTVKETLRIYHGKTNNTKENDNFSFSNYLIDSREITKGIQVDIEKAIKQGKSIILSGHNLFLPYIFELHSGGLFPAPILINEMEDDSVNHSFPLYFLPRKNEDSISLLFIPILLKADLKKTRVNPEKIDFLQKLQDEIISNTVNNATNWPVHIVSHDPEIPQKTSRTIHQIIIKSLKKAIHPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXT2</accession>
    <name>Q5CXT2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_5040</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628648.1">
        <property type="nucleotide sequence ID" value="XM_628646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXT2"/>
    <dbReference type="GeneID" id="3372083"/>
    <dbReference type="KEGG" id="cpv:cgd7_5040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5040"/>
    <dbReference type="InParanoid" id="Q5CXT2"/>
    <dbReference type="OMA" id="INNIPAC"/>
    <dbReference type="OrthoDB" id="340461at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="624"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="650"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1040" mass="118275" checksum="391688C15146DD4F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXV3</accession>
    <name>Q5CXV3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">ABC transporter, amino acid transporter 12 transmembrane spanning subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_4800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628627.1">
        <property type="nucleotide sequence ID" value="XM_628625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXV3"/>
    <dbReference type="STRING" id="353152.Q5CXV3"/>
    <dbReference type="GeneID" id="3371952"/>
    <dbReference type="KEGG" id="cpv:cgd7_4800"/>
    <dbReference type="InParanoid" id="Q5CXV3"/>
    <dbReference type="OMA" id="NCTIFFY"/>
    <dbReference type="OrthoDB" id="339469at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF666">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="96"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="138"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="204"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="239"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="284"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="522"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="548"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="584"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="28"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="6">
        <location>
            <begin position="517"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="619" mass="69169" checksum="50C9ADA2162C81CC" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY30</accession>
    <name>Q5CY30_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">DNAJ domain protein sec63 ortholog, 4 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd7_3880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90381.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628550.1">
        <property type="nucleotide sequence ID" value="XM_628548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY30"/>
    <dbReference type="FunCoup" id="Q5CY30">
        <property type="interactions" value="489"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY30"/>
    <dbReference type="GeneID" id="3372136"/>
    <dbReference type="KEGG" id="cpv:cgd7_3880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3880"/>
    <dbReference type="InParanoid" id="Q5CY30"/>
    <dbReference type="OMA" id="LIPCTYI"/>
    <dbReference type="OrthoDB" id="1734229at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031207">
        <property type="term" value="C:Sec62/Sec63 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008320">
        <property type="term" value="F:protein transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006620">
        <property type="term" value="P:post-translational protein targeting to endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000077">
        <property type="entry name" value="Translocation protein SEC63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075">
        <property type="entry name" value="SEC63 DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24075:SF0">
        <property type="entry name" value="TRANSLOCATION PROTEIN SEC63 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="217"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="11">
        <location>
            <begin position="129"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="607"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90381.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="627" mass="71593" checksum="21E4071B29C964FF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYA4</accession>
    <name>Q5CYA4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">LsmAD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_3100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628476.1">
        <property type="nucleotide sequence ID" value="XM_628474.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYA4"/>
    <dbReference type="STRING" id="353152.Q5CYA4"/>
    <dbReference type="GeneID" id="3372292"/>
    <dbReference type="KEGG" id="cpv:cgd7_3100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3100"/>
    <dbReference type="InParanoid" id="Q5CYA4"/>
    <dbReference type="OrthoDB" id="2275718at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010494">
        <property type="term" value="C:cytoplasmic stress granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034063">
        <property type="term" value="P:stress granule assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045117">
        <property type="entry name" value="ATXN2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009604">
        <property type="entry name" value="LsmAD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854">
        <property type="entry name" value="ATAXIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12854:SF7">
        <property type="entry name" value="ATAXIN-2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06741">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01272">
        <property type="entry name" value="LsmAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LsmAD" evidence="2">
        <location>
            <begin position="236"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="322"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="325"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01272"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="554" mass="64311" checksum="CC72453344F81EFD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYG8</accession>
    <name>Q5CYG8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Tyrosyl-DNA phodphodiesterase 1 (Tdp1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd7_2390</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the tyrosyl-DNA phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628412.1">
        <property type="nucleotide sequence ID" value="XM_628410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYG8"/>
    <dbReference type="STRING" id="353152.Q5CYG8"/>
    <dbReference type="GeneID" id="3372210"/>
    <dbReference type="KEGG" id="cpv:cgd7_2390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2390"/>
    <dbReference type="InParanoid" id="Q5CYG8"/>
    <dbReference type="OMA" id="PLIKECW"/>
    <dbReference type="OrthoDB" id="47785at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017005">
        <property type="term" value="F:3'-tyrosyl-DNA phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004527">
        <property type="term" value="F:exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09122">
        <property type="entry name" value="PLDc_Tdp1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09123">
        <property type="entry name" value="PLDc_Tdp1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010347">
        <property type="entry name" value="Tdp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12415:SF0">
        <property type="entry name" value="TYROSYL-DNA PHOSPHODIESTERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06087">
        <property type="entry name" value="Tyr-DNA_phospho"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="active site" description="Nucleophile" evidence="9">
        <location>
            <position position="161"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="9">
        <location>
            <position position="390"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="163"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="392"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Interaction with DNA" evidence="11">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010205"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR610347-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="511" mass="59911" checksum="2B6F684596720517" modified="2005-04-12" version="1">MAANEKFDVLRSPHFKKPKFGYDVIEISSDSSIESKLGDISSNNYLKLETPIYLNKLNFEKKNLKNLSFKSLFVVNDCTPIEKSVWRIKHILFSSYLADVNWVINEIGDSELICENIESILFVSHGFDNPQNYKLKNFNKVKNKKISTYSPYLKVPYGVFHPKFILLVFEHLVQPKKNFVRFVVTSANLIQQDWELKIQSIWVQDFFHSIERKDCEFLDYLQEFLKNILNGSKLKDFWLSKVQEFNFEDATVKLVASVPGYFFGDEMFMWGHLRVRSLIKRFVSKDQDKSDELREKRERIVLQFSSLGRISEKWLYTELASSLSEIPGTELEIIFPTVEQVVNSIEGINGGGSLPVKKEYICKPWIKKLLHKWGTGTMKKNATDEKVIPHIKTFLKYKIFGNAIKIIWLVQGSYNLSNAAWGQIQKDGSQFCIRNYELGIFIHKDQFEFERYFKLNEEFPKFFWKRKSNCSLISEINANQPNVLLNFPLPFKLPPKRYSNSDHPWNIELLM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYQ1</accession>
    <name>Q5CYQ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_1450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628329.1">
        <property type="nucleotide sequence ID" value="XM_628327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYQ1"/>
    <dbReference type="GeneID" id="3372247"/>
    <dbReference type="KEGG" id="cpv:cgd7_1450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1450"/>
    <dbReference type="InParanoid" id="Q5CYQ1"/>
    <dbReference type="OMA" id="KFTNTHE"/>
    <dbReference type="OrthoDB" id="339017at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="369" mass="42218" checksum="D8F33C7C4FCDB6FB" modified="2005-04-12" version="1">MRFVFTSDYNDDNSLSHSSYLNRPNAYGYSRKEFKARSLEHSSKTAKRILSHIIPELSISQFNESVRIFNAYLESYKNTPKSIPRIESLISASAYISVRKDGGYLSLLDIASRLKSKNYRSFASLIKRICTRLRIKNLPNPSIEESLNHLCYKVEKFLKEKTIQNANEQYQKETIIFQNPEKETDDIRNLMLDSLIKDSSIDLESKKLRNYNSNPGSFLNSMKHLKTKTEAKTSLDSLIKAKNFSLLILKTIALDQDHASLNNHDDILNPLWLSNGVSSTPIISASLYFSFKLYCRNISFNDLLKATGVSKSSIIKARRSLSHKLRLISQKLFPGWLSSDMLNCNSELPPTIIESLTKLIQSYYSNLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYS4</accession>
    <name>Q5CYS4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_1210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628306.1">
        <property type="nucleotide sequence ID" value="XM_628304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYS4"/>
    <dbReference type="STRING" id="353152.Q5CYS4"/>
    <dbReference type="GeneID" id="3371851"/>
    <dbReference type="KEGG" id="cpv:cgd7_1210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1210"/>
    <dbReference type="InParanoid" id="Q5CYS4"/>
    <dbReference type="OrthoDB" id="344231at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254671" evidence="3">
        <location>
            <begin position="21"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="43"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="149"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="57"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="70"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="203" mass="22818" checksum="A5448B7536BB33B9" modified="2005-04-12" version="1">MKFCLIIVSIFFVFLNHFLGFSADVQIAGNSFLKIRVKSGNQDLNSNSESDDKKGSESNSGASEAALTSQPPPPPPPPSLPPPVVCKKCNLTPKQEIVITASITKLKRFLQRLEDLEKELSPEIKILYSKLKKILLKLLQCLESCLVDISSCIKCLESVEEELEKLIKEAEKDVDEDFLEVIREILKFVQSVKQYKHCNLPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYV0</accession>
    <name>Q5CYV0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein with 2 possible TPR domains, possible n-terminal acetyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_920</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628280.1">
        <property type="nucleotide sequence ID" value="XM_628278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYV0"/>
    <dbReference type="FunCoup" id="Q5CYV0">
        <property type="interactions" value="341"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYV0"/>
    <dbReference type="GeneID" id="3371775"/>
    <dbReference type="KEGG" id="cpv:cgd7_920"/>
    <dbReference type="InParanoid" id="Q5CYV0"/>
    <dbReference type="OMA" id="MEMRADY"/>
    <dbReference type="OrthoDB" id="10263032at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1010">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1040">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021183">
        <property type="entry name" value="NatA_aux_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767:SF2">
        <property type="entry name" value="N(ALPHA)-ACETYLTRANSFERASE 15_16, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22767">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12569">
        <property type="entry name" value="NatA_aux_su"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="100"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1067" mass="125068" checksum="E8BFCC482BE7DFCC" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYV2</accession>
    <name>Q5CYV2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628278.1">
        <property type="nucleotide sequence ID" value="XM_628276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYV2"/>
    <dbReference type="GeneID" id="3371989"/>
    <dbReference type="KEGG" id="cpv:cgd7_900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_900"/>
    <dbReference type="InParanoid" id="Q5CYV2"/>
    <dbReference type="OrthoDB" id="343845at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="66"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="113"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="471"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="279"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="288"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="316"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="58346" checksum="D25D6D92964C12DD" modified="2005-04-12" version="1">MIDNYQEFLTDSERSHELSFSTVLDEIIISELNEDPNINLDNWTSVPKMKIDLFSYLEIMDKLGEILFYKYSFNILVFLLIQIIQRNSRNILDFDNKFDTILIKSNIFIYNSWSFYLLVYTIGVIYSIFLFNKEKYLCKFLFFQNDIFNHNQFSGIYNTWCSIIGVVSRFHEIVDIIFFSYLSSQYLKLSQSVLFFLVRLSFLVIQVRSFLAAGNITSSFNWITNNTQNPGQTSSFGSQNLHSSSSSSSSSYYSTIKAELYQNQDNFGCQEVNQQISPLSSSSFHSTKSQEQDIGRDQSMDIHSKKRSKKKDDCHLSSQVLSDLPSSSSSSSSSLSVSLTSFLSALPSVHQDNFLFCKFSQTFFTQGLISYFHFNASDSFRVALTKYTSQLKQNQTKIKPFKILQLADLAFYLDLFSLENILYSLYILNKHKETHEFNISTYFLWKVLSNDLIINIYKLFFLIFVSRLSKIYIILTLTISSLSISSLFLYLHVNKQVINDVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ24</accession>
    <name>Q5CZ24_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ring domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_100</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90663.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628206.1">
        <property type="nucleotide sequence ID" value="XM_628204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ24"/>
    <dbReference type="STRING" id="353152.Q5CZ24"/>
    <dbReference type="GeneID" id="3371760"/>
    <dbReference type="KEGG" id="cpv:cgd7_100"/>
    <dbReference type="InParanoid" id="Q5CZ24"/>
    <dbReference type="OMA" id="MCPICVH"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051438">
        <property type="entry name" value="RNF_E3_ubiq-protein_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018957">
        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46016:SF1">
        <property type="entry name" value="RING-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46016">
        <property type="entry name" value="ZINC FINGER, RING/FYVE/PHD-TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="50"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90663.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="344" mass="38339" checksum="7792DEFC418C3A19" modified="2005-04-12" version="1" fragment="single">EVECGGAFEIEMFEWTNIFSSFSRPSDLALDTDKNDVSKDFIEIPEQFMCPICLGAFVDPCTLSCSHSFCISCVRGSHECPICRSLLKEELWLSKSDQLVDQSILRSMNETKTKCHCGAEISISEANSHASKCSYCKEDDSPTSESKLIASLSKQSFVNNDLQAQSSNGPSNTRTTSNTTGPTFVCPLCLMNSKIPNSSCLKYNVESLISHCETMHKDEYSETQQESNHMTTMCPICVHIGDENAEVECKRFLQHLKSKHLLISTFLAAARASLNSGSPESRFQLLEDILFQYALSRSRYESCMNPGNDNSQSFGSSVIEIIGLDDEQDNSEMFQDDDEIQEIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ30</accession>
    <name>Q5CZ30_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Large uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_30</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628200.1">
        <property type="nucleotide sequence ID" value="XM_628198.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372027"/>
    <dbReference type="KEGG" id="cpv:cgd7_30"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_30"/>
    <dbReference type="InParanoid" id="Q5CZ30"/>
    <dbReference type="OMA" id="DWIHESK"/>
    <dbReference type="OrthoDB" id="71437at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2474" mass="279626" checksum="84EBD99FBF662A2F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPT3</accession>
    <name>A3FPT3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Cyclin-dependent kinase 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="9">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd6_1420</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="6">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388312.1">
        <property type="nucleotide sequence ID" value="XM_001388275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPT3"/>
    <dbReference type="STRING" id="353152.A3FPT3"/>
    <dbReference type="GeneID" id="3375937"/>
    <dbReference type="KEGG" id="cpv:cgd6_1420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1420"/>
    <dbReference type="InParanoid" id="A3FPT3"/>
    <dbReference type="OMA" id="EANDHTD"/>
    <dbReference type="OrthoDB" id="387075at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032968">
        <property type="term" value="P:positive regulation of transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF546">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="10"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="417"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="543"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="421"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="465"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="543"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="555"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="576"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="589"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="618"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="633"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAZ51506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="645" mass="75033" checksum="41E0BE42709641E4" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPZ6</accession>
    <name>A3FPZ6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">type I protein arginine methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.319</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_3420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>L-arginyl-[protein] + S-adenosyl-L-methionine = N(omega)-methyl-L-arginyl-[protein] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48100"/>
            <dbReference type="Rhea" id="RHEA-COMP:10532"/>
            <dbReference type="Rhea" id="RHEA-COMP:11990"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29965"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65280"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="5">
            <dbReference type="Rhea" id="RHEA:48101"/>
        </physiologicalReaction>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.319" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51477.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388437.1">
        <property type="nucleotide sequence ID" value="XM_001388400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPZ6"/>
    <dbReference type="STRING" id="353152.A3FPZ6"/>
    <dbReference type="GeneID" id="3374656"/>
    <dbReference type="KEGG" id="cpv:cgd8_3420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3420"/>
    <dbReference type="InParanoid" id="A3FPZ6"/>
    <dbReference type="OMA" id="QQTMIYF"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035242">
        <property type="term" value="F:protein-arginine omega-N asymmetric methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035241">
        <property type="term" value="F:protein-arginine omega-N monomethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000003">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF124">
        <property type="entry name" value="ARGININE METHYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="7">
        <location>
            <begin position="149"/>
            <end position="309"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51477.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="324" mass="36966" checksum="88FC94EF1A9C9964" modified="2007-04-03" version="1">MSTLDTYSRSYDDLLVHQLMLQDVERVEAYKRSFEENKELFKGKIVLDVGCGTGILSMLAAKCGAKAVYAVDGSNISFLAKTIVEDNELSEVVKVIHGVIEEIELPVNQVDIIVSEWMGFYLLHEGMLDSVIFARDKWLNSKHGVIFPEKASLYVSLVEIEDFWYKNIEGINNIQGFDYSSMRRIIHSSYLKSPLILGVEPKNVENFSFARILSLDLLKININDLDIIKSQFTLKVKKDTEFVHGFIVWFDIEFPAHKSNAIILSTSPYDKPTHWKQTIVLFQDCLEAKAGLNLKCLSKLERCVNESKRCYTISIEVQDASIEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPZ9</accession>
    <name>A3FPZ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd8_4110</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SEC13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388440.1">
        <property type="nucleotide sequence ID" value="XM_001388403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPZ9"/>
    <dbReference type="STRING" id="353152.A3FPZ9"/>
    <dbReference type="GeneID" id="3374659"/>
    <dbReference type="KEGG" id="cpv:cgd8_4110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4110"/>
    <dbReference type="InParanoid" id="A3FPZ9"/>
    <dbReference type="OMA" id="MNDKPHN"/>
    <dbReference type="OrthoDB" id="364224at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030127">
        <property type="term" value="C:COPII vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090114">
        <property type="term" value="P:COPII-coated vesicle budding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000655">
        <property type="entry name" value="Protein transport protein SEC13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024:SF2">
        <property type="entry name" value="PROTEIN SEC13 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="9" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0811">Translocation</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4 11" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="9"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="11">
        <location>
            <begin position="53"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="324"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="324"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="364"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="414"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="474"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="542"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="560"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="12">
        <location>
            <begin position="581"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAZ51480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="601" mass="63718" checksum="5C293CF13C51D6AC" modified="2007-04-03" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ04</accession>
    <name>A3FQ04_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribosomal processing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388445.1">
        <property type="nucleotide sequence ID" value="XM_001388408.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A3FQ04">
        <property type="interactions" value="568"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ04"/>
    <dbReference type="GeneID" id="3374359"/>
    <dbReference type="KEGG" id="cpv:cgd8_4530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4530"/>
    <dbReference type="InParanoid" id="A3FQ04"/>
    <dbReference type="OMA" id="DIRSSTX"/>
    <dbReference type="OrthoDB" id="10249065at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051733">
        <property type="entry name" value="WD_repeat_DCAF13/WDSOF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851:SF0">
        <property type="entry name" value="DDB1- AND CUL4-ASSOCIATED FACTOR 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22851">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA U3 SNORNA ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="62"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="106"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="269" mass="30560" checksum="17582A5B2AF27FD5" modified="2007-04-03" version="1">MKVKVLQRDVNKYQDRSKGSVQRIYHNPDPNIHPFEKAREYSRALMSVKLRKMFSKPLVSVFEGHSDTVQCLARAHHHLSDIYSGGFDGTIRYWNLAGSRRCEYMIRAHEGAVRGLCVTNNDKHLFSCGDDKKLQMWKISKRESVNEMNLMELEDGGNVEDVFNGYDNISSFSKAIIPETTFLANNQLYSLDHHWNSGVLISSGVGGLHVWDRHRSTPLQEFEWGNETVYSAKINPSEPHIVATVSSDNSVGLFDIRSSTXXXXVXXSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ99</accession>
    <name>A3FQ99_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd2_3410</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388235.1">
        <property type="nucleotide sequence ID" value="XM_001388198.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ99"/>
    <dbReference type="STRING" id="353152.A3FQ99"/>
    <dbReference type="GeneID" id="3373539"/>
    <dbReference type="KEGG" id="cpv:cgd2_3410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3410"/>
    <dbReference type="InParanoid" id="A3FQ99"/>
    <dbReference type="OMA" id="IRQRHWF"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003500">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="24"/>
            <end position="31"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="31"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="70"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="126"/>
            <end position="129"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAZ51408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="182" mass="20701" checksum="1F205309BCC2C6F7" modified="2007-04-03" version="1">MGLALSRIWNRLFGKKEMRILMVGLDAAGKTTILYKLKLGEVVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYYTNTDGIIFVVDSNDRERINDSRDELMRMLGEDELRDATLLVLANKQDLPNAMSVTEVTEKLQLSSLRHRSWFIQSTCATAGDGLYEGLDWLARNLEKAAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQA8</accession>
    <name>A3FQA8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ORF 73, contains large complex repeat CR 73, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_4130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388244.1">
        <property type="nucleotide sequence ID" value="XM_001388207.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQA8"/>
    <dbReference type="GeneID" id="3373664"/>
    <dbReference type="KEGG" id="cpv:cgd2_4130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4130"/>
    <dbReference type="InParanoid" id="A3FQA8"/>
    <dbReference type="OMA" id="DFICTYH"/>
    <dbReference type="OrthoDB" id="343286at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90257">
        <property type="entry name" value="Myosin rod fragments"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="141"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="244"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="49"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="244"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="267"/>
            <end position="276"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="340" mass="38694" checksum="5EB67484A97CB7C5" modified="2007-04-03" version="1">MSLLSIQKPQGVLELGISEIENSTRKLVENETRKFEAYIDILRDQMMGMGELEHENEILQGEVARITEQLSLRELDMESKEKKIFELEKSSKDFQQMNKDYEKKLSELTEEKNSLKTQLNEMNAQIEKLLNEKITSEKVVQGNDEKQIASKIKSKKRTQEEHADENNSTNKVSKEAPTLKKSRLRRPQNEDSSESKKSISKDTEPIIQEEKLEKEENPLKSVLGKTNLGRLRAPLLRNRVVKAAEAANPEVENAPELKTIEKEKSGSGRSSKSSSVESKKSGKKTSKVAKIAKIPHYDENILNSMKVIELKDVCSKLQLEISQRARKSDLIQSIISFQGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQC4</accession>
    <name>A3FQC4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_740</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388146.1">
        <property type="nucleotide sequence ID" value="XM_001388109.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQC4"/>
    <dbReference type="STRING" id="353152.A3FQC4"/>
    <dbReference type="GeneID" id="3371496"/>
    <dbReference type="KEGG" id="cpv:cgd1_740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_740"/>
    <dbReference type="InParanoid" id="A3FQC4"/>
    <dbReference type="OMA" id="CMARANC"/>
    <dbReference type="OrthoDB" id="10266026at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12872">
        <property type="entry name" value="SPRY_Ash2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037353">
        <property type="entry name" value="ASH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001309">
        <property type="entry name" value="Pept_C14_p20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598">
        <property type="entry name" value="SET1/ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10598:SF0">
        <property type="entry name" value="SET1_ASH2 HISTONE METHYLTRANSFERASE COMPLEX SUBUNIT ASH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00449">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50208">
        <property type="entry name" value="CASPASE_P20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="4">
        <location>
            <begin position="28"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Caspase family p20" evidence="5">
        <location>
            <begin position="78"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="282" mass="31655" checksum="2331EA47829FC4BA" modified="2007-04-03" version="1" fragment="single">MTENSVKIESHSKKETISHLNESASTSNPRKKSRKNTGKDNKVDNFDSPVFSVRYKDPSIELSDDRLTAVGYKGWSTVLLTHGASSGVWYFEITVLEPRVISKFLGHSKFLNLKQDPSIRVGWSCRYNRLDTPVGTSTFGYSFNTKTYSIFSNAKAQEIHESEKITQINPGDVIGCLIKLSGVPYELEDPRNCPHLHPYLELGLLCNPEVLPKVINDPNSLIEFYINGKKLSANFTNIPSGFYHPTVSLYMGSSVKINIGPNFAFFPHTELEPALKLLRPQI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQS2</accession>
    <name>A3FQS2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Peptidase'insulinase like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_5520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000016">
        <property type="protein sequence ID" value="EAZ51200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388359.1">
        <property type="nucleotide sequence ID" value="XM_001388322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQS2"/>
    <dbReference type="SMR" id="A3FQS2"/>
    <dbReference type="STRING" id="353152.A3FQS2"/>
    <dbReference type="GeneID" id="3375634"/>
    <dbReference type="KEGG" id="cpv:cgd6_5520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5520"/>
    <dbReference type="InParanoid" id="A3FQS2"/>
    <dbReference type="OMA" id="ENICHET"/>
    <dbReference type="OrthoDB" id="446660at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002652590" evidence="7">
        <location>
            <begin position="22"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="83"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="229"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="570" mass="68418" checksum="8098F1F2F1DAF0C5" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPG9</accession>
    <name>Q5CPG9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625324.1">
        <property type="nucleotide sequence ID" value="XM_625324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPG9"/>
    <dbReference type="GeneID" id="3372317"/>
    <dbReference type="KEGG" id="cpv:cgd3_100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_100"/>
    <dbReference type="InParanoid" id="Q5CPG9"/>
    <dbReference type="OMA" id="QTCESEY"/>
    <dbReference type="OrthoDB" id="341631at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="365"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="383"/>
            <end position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="397" mass="45457" checksum="BB4A9E1E02BC3119" modified="2005-04-12" version="1">MVAWKKTILFQYIYVTILLGISLIFVCAEEVQNVSEFSQALPNTELNFGYNQGQALVESNIRFPTIGSFFSWLGSFNSLYVKYERTFEEIATSIPPKEDLESQITLMTTYSFLLQCLKTMGELNSIYEASILETNSDMLSDDSSSSVSNLLKECLIPFKDLLLKSFIALQDQAFDSGKTYSPALLKSSELIMELYEICWSIFTTILGYITMFQQSMNILLRNRSENQEKLKFLENKQEKSSLEQLQSNIYTRRLVDISREEKLISLVLTLFEGDFSVSINILELESLITTENKRSISELEESIKNLEKSIKCDVNSEENSNMLLVKALKEELDSRTNDLVRQTSGPPIYLQRYDQELTEIFTKLNLEGSQSDSTNEQNEADDETKVKVEEADPKEVQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPH4</accession>
    <name>Q5CPH4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_50</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM135 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625319.1">
        <property type="nucleotide sequence ID" value="XM_625319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPH4"/>
    <dbReference type="ESTHER" id="crypv-q5cph4">
        <property type="family name" value="Duf_676"/>
    </dbReference>
    <dbReference type="GeneID" id="3372322"/>
    <dbReference type="KEGG" id="cpv:cgd3_50"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_50"/>
    <dbReference type="InParanoid" id="Q5CPH4"/>
    <dbReference type="OMA" id="CHIGCII"/>
    <dbReference type="OrthoDB" id="273452at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022122">
        <property type="entry name" value="DUF3657"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482:SF5">
        <property type="entry name" value="DUF676 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12394">
        <property type="entry name" value="DUF3657"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DUF676" evidence="2">
        <location>
            <begin position="949"/>
            <end position="1133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007949"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1208" mass="137023" checksum="5F1D7F9661E0EF49" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPL7</accession>
    <name>Q5CPL7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5 6">Eukaryotic translation initiation factor 3 subunit B</fullName>
            <shortName evidence="5 6">eIF3b</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 9</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.</text>
    </comment>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 6">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5 6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the eIF-3 subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625404.1">
        <property type="nucleotide sequence ID" value="XM_625404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPL7"/>
    <dbReference type="FunCoup" id="Q5CPL7">
        <property type="interactions" value="622"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPL7"/>
    <dbReference type="GeneID" id="3372383"/>
    <dbReference type="KEGG" id="cpv:cgd2_360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_360"/>
    <dbReference type="InParanoid" id="Q5CPL7"/>
    <dbReference type="OMA" id="LWGGPQF"/>
    <dbReference type="OrthoDB" id="10250414at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03001">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011400">
        <property type="entry name" value="EIF3B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 EIF3 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14068:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036424">
        <property type="entry name" value="eIF3b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5 6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="7">
        <location>
            <begin position="408"/>
            <end position="614"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03001"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR036424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="724" mass="84047" checksum="7F3F8675BF843B30" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPM8</accession>
    <name>Q5CPM8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ubiquitin-conjugating enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625393.1">
        <property type="nucleotide sequence ID" value="XM_625393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPM8"/>
    <dbReference type="GeneID" id="3372362"/>
    <dbReference type="KEGG" id="cpv:cgd2_240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_240"/>
    <dbReference type="InParanoid" id="Q5CPM8"/>
    <dbReference type="OMA" id="WEEQIND"/>
    <dbReference type="OrthoDB" id="5596422at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd23814">
        <property type="entry name" value="UEV_AKTIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000608">
        <property type="entry name" value="UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50127">
        <property type="entry name" value="UBC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBC core" evidence="1">
        <location>
            <begin position="47"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="288" mass="33704" checksum="6D9B754406012709" modified="2005-04-12" version="1">MNLGLWNPITLEVENSRLTYFSIRSDQLLKKSNSNKNNEDKLVREIILDYKYLIDYSCLLEFSPDGLYVIPEYENIYTWQGGIFIRSGLYAGAFYRFQIELALEREYVSDGSELKTHKVEFLNPPAHPLVSISSGLLYIPNEWQAKIQNNVLALLFFIKNIFYLPELITYKLDDQEIGNVEMSDSVRNDPKKAIYKIQRSVKDSIEKSCRAYNSKFSPFKLNYHVNDSDKNEDKEEAKQEFHYNIDDDLSADIVEYIKECVQNSSNINEQKESLNEWILNIVDKNKLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPU2</accession>
    <name>Q5CPU2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Small ribosomal subunit protein uS5</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">40S ribosomal protein S2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_4020</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the universal ribosomal protein uS5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625422.1">
        <property type="nucleotide sequence ID" value="XM_625422.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPU2"/>
    <dbReference type="FunCoup" id="Q5CPU2">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPU2"/>
    <dbReference type="GeneID" id="3372408"/>
    <dbReference type="KEGG" id="cpv:cgd4_4020"/>
    <dbReference type="InParanoid" id="Q5CPU2"/>
    <dbReference type="OMA" id="PYEEWSD"/>
    <dbReference type="OrthoDB" id="10253125at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.160.20:FF:000002">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000004">
        <property type="entry name" value="40S ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000851">
        <property type="entry name" value="Ribosomal_uS5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005324">
        <property type="entry name" value="Ribosomal_uS5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005711">
        <property type="entry name" value="Ribosomal_uS5_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013810">
        <property type="entry name" value="Ribosomal_uS5_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018192">
        <property type="entry name" value="Ribosomal_uS5_N_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01020">
        <property type="entry name" value="uS5_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718:SF4">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13718">
        <property type="entry name" value="RIBOSOMAL S SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00333">
        <property type="entry name" value="Ribosomal_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03719">
        <property type="entry name" value="Ribosomal_S5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00585">
        <property type="entry name" value="RIBOSOMAL_S5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50881">
        <property type="entry name" value="S5_DSRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="S5 DRBM" evidence="9">
        <location>
            <begin position="98"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="23"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="278" mass="30314" checksum="430D4D51D0A5875F" modified="2005-04-12" version="1" fragment="single">ILINLNSIDYLYLASERGGFGKGFGSRGGDRGGRGKGPRGRSRASPAEDELKSWVPVTKLGRLVRDGKINSIEEIYLHSLPIKEHQIVDYFFSGSSQLSEEVMKIMPVQKQTRAGQRTRYKAFVAVGDFNGHIGLGVKCAKEVATAIRGGIIAAKLSLVPVRRGYWGNKIGEPHTVPMKVSGKCGSVLVRLVPAPRGTAIVGAPTTKKMLQFAGVKDCFTSSRGCTKTRGNFMLAIFAALKSTYAYLTPDLWKEYSFTPSPYKQFSDFLAVTNSKVTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPW2</accession>
    <name>Q5CPW2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Proteasome regulatory subunit S2 (RPN1)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_570</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the proteasome subunit S2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625517.1">
        <property type="nucleotide sequence ID" value="XM_625517.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CPW2">
        <property type="interactions" value="532"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPW2"/>
    <dbReference type="GeneID" id="3372475"/>
    <dbReference type="KEGG" id="cpv:cgd8_570"/>
    <dbReference type="InParanoid" id="Q5CPW2"/>
    <dbReference type="OMA" id="GTCNGDI"/>
    <dbReference type="OrthoDB" id="10252509at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008540">
        <property type="term" value="C:proteasome regulatory particle, base subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034515">
        <property type="term" value="C:proteasome storage granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030234">
        <property type="term" value="F:enzyme regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042176">
        <property type="term" value="P:regulation of protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016643">
        <property type="entry name" value="26S_Psome_Rpn1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002015">
        <property type="entry name" value="Proteasome/cyclosome_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041433">
        <property type="entry name" value="RPN1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040892">
        <property type="entry name" value="RPN1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10943:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01851">
        <property type="entry name" value="PC_rep"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18051">
        <property type="entry name" value="RPN1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17781">
        <property type="entry name" value="RPN1_RPN2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015965">
        <property type="entry name" value="26S_Psome_Rpn1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0647">Proteasome</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="RPN1 N-terminal" evidence="5">
        <location>
            <begin position="55"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="domain" description="26S proteasome non-ATPase regulatory subunit RPN1 C-terminal" evidence="6">
        <location>
            <begin position="982"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="659"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="14"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF18051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1045" mass="114956" checksum="14FE17E86F4795A5" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPZ0</accession>
    <name>Q5CPZ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625489.1">
        <property type="nucleotide sequence ID" value="XM_625489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPZ0"/>
    <dbReference type="GeneID" id="3372508"/>
    <dbReference type="KEGG" id="cpv:cgd8_260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_260"/>
    <dbReference type="InParanoid" id="Q5CPZ0"/>
    <dbReference type="OMA" id="MELCILE"/>
    <dbReference type="OrthoDB" id="339138at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="788" mass="90026" checksum="D98C003502E8ACAE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ06</accession>
    <name>Q5CQ06_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_90</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625473.1">
        <property type="nucleotide sequence ID" value="XM_625473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ06"/>
    <dbReference type="GeneID" id="3372493"/>
    <dbReference type="KEGG" id="cpv:cgd8_90"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_90"/>
    <dbReference type="InParanoid" id="Q5CQ06"/>
    <dbReference type="OMA" id="TINRIYI"/>
    <dbReference type="OrthoDB" id="339747at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="949" mass="109394" checksum="8654E79F25A1BBA7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ56</accession>
    <name>Q5CQ56_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Matrin-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd5_4060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625570.1">
        <property type="nucleotide sequence ID" value="XM_625570.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ56"/>
    <dbReference type="FunCoup" id="Q5CQ56">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ56"/>
    <dbReference type="GeneID" id="3372522"/>
    <dbReference type="KEGG" id="cpv:cgd5_4060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4060"/>
    <dbReference type="InParanoid" id="Q5CQ56"/>
    <dbReference type="OrthoDB" id="76567at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030627">
        <property type="term" value="F:pre-mRNA 5'-splice site binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000395">
        <property type="term" value="P:mRNA 5'-splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013085">
        <property type="entry name" value="U1-CZ_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017340">
        <property type="entry name" value="U1_snRNP-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31148:SF1">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06220">
        <property type="entry name" value="zf-U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037969">
        <property type="entry name" value="U1_snRNP-C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="9">
        <location>
            <begin position="4"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="174"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="102"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="198" mass="22431" checksum="EE4922050BD18599" modified="2005-04-12" version="1">MPKFYCDYCDIYLTHSSTNGRKQHNLGRKHINNKIDHYKNVIKSPSFSAPLMFDSEYNVIGHLGNVRQFLLNLEKQLSVDKKHTNKHETKDKESAKPTSYKNNKTPIGNNNNHSNNIIKGGSGNANYNTGNPYVNQERFHYKSTNSGGNSAFANYGRPEHSSYSNNYSNYYRGGQIDDGDGGSRSYKKGPVQNYGGRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ82</accession>
    <name>Q5CQ82_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">SNF7 ortholog</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_3790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625544.1">
        <property type="nucleotide sequence ID" value="XM_625544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ82"/>
    <dbReference type="FunCoup" id="Q5CQ82">
        <property type="interactions" value="303"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ82"/>
    <dbReference type="GeneID" id="3372589"/>
    <dbReference type="KEGG" id="cpv:cgd5_3790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3790"/>
    <dbReference type="InParanoid" id="Q5CQ82"/>
    <dbReference type="OMA" id="DKIDDMM"/>
    <dbReference type="OrthoDB" id="5592979at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009898">
        <property type="term" value="C:cytoplasmic side of plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000815">
        <property type="term" value="C:ESCRT III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005771">
        <property type="term" value="C:multivesicular body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032511">
        <property type="term" value="P:late endosome to vacuole transport via multivesicular body sorting pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006900">
        <property type="term" value="P:vesicle budding from membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005024">
        <property type="entry name" value="Snf7_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761">
        <property type="entry name" value="CHARGED MULTIVESICULAR BODY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22761:SF10">
        <property type="entry name" value="GH13992P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03357">
        <property type="entry name" value="Snf7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0967">Endosome</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="30"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="205" mass="23195" checksum="65658D51D36807E9" modified="2005-04-12" version="1">MFLFRRKQEKEETNPLSEIESAHEKALKASQAIQRSLLDLEEKEKKLENEAANLALQGDKNSALLVLRRKKLVTQEREKLLSSSLLLEQQLLNLETAKTQQMTMSALSASAMAHQSIISSTNTDKLEKISDTIKEQQSIHDEISQIINQSLPSMNEADLMEELSAIQAKEIDRKILESSEIFTTNNKVLLNSSTSNLDEKIMEKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQB0</accession>
    <name>Q5CQB0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">carnosine N-methyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_1420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the carnosine N-methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87610.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625738.1">
        <property type="nucleotide sequence ID" value="XM_625738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQB0"/>
    <dbReference type="GeneID" id="3372637"/>
    <dbReference type="KEGG" id="cpv:cgd4_1420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1420"/>
    <dbReference type="InParanoid" id="Q5CQB0"/>
    <dbReference type="OMA" id="WSHHATE"/>
    <dbReference type="OrthoDB" id="978at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030735">
        <property type="term" value="F:carnosine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012901">
        <property type="entry name" value="CARME"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12303:SF6">
        <property type="entry name" value="CARNOSINE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07942">
        <property type="entry name" value="CARME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01296">
        <property type="entry name" value="N2227"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87610.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="437" mass="50978" checksum="A9E8699FF393EA56" modified="2005-04-12" version="1">MSDIDSSSDNEKMNEIVYYNGNDEDMFRYLEYFQNNFPLCPKEIDNNEEVKEHIESDYNHFISVVTSFLMYEWDCIKDLARIERNFYSLSREDRELLGISNIEDEINKFRNCINANQNFLKLMLSPDLYYDQIELNNNNNNNNNNNNNNRLNENKSFKTSANKNINHIPNTTLNNLCKVKATLRQFVRDWSEHGREEREESYDPMIQALKDYLPINTNSSSSEKIKVLIPGAGLGRLLFEVARLGYSCQGNEISYAMLLGSNFALNYMFKVNSIVIYPYVLSLSNRPKKEDNLRPIHIPDICVNEYIKQGHDLSMCAGDFVEIYSKQAQAWDAILTCFFLDTAKNIITYIRTITNLLPPNGVWINLGPLLYHYSGLNNVISIEPSWEEIKRIISKYFKIVKEEWRNATYTRNNSSMFKIVYKCIFFVAIRNKVGLSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQN6</accession>
    <name>Q5CQN6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_10</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625612.1">
        <property type="nucleotide sequence ID" value="XM_625612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQN6"/>
    <dbReference type="STRING" id="353152.Q5CQN6"/>
    <dbReference type="GeneID" id="3372609"/>
    <dbReference type="KEGG" id="cpv:cgd4_10"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_10"/>
    <dbReference type="InParanoid" id="Q5CQN6"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254269" evidence="2">
        <location>
            <begin position="23"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="160" mass="17840" checksum="A5B3270CC7B15BF1" modified="2005-04-12" version="1">MKIFKLHLFISFLFLIFQYPSSISFHSNLLSFSFIKVKSPCCKAMRRIRRRLCCCCCSTSCDSDSEDELNSSSNTSEEQGHSNCQFNPESIDLEVIPPPPPFPAPQAPVESLSFSPPPSQEEIGSSFSSEDPDSLPSLPPPPPPVLPKPRRSVLRRVLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQT8</accession>
    <name>Q5CQT8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625914.1">
        <property type="nucleotide sequence ID" value="XM_625914.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQT8"/>
    <dbReference type="GeneID" id="3372776"/>
    <dbReference type="KEGG" id="cpv:cgd4_3370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3370"/>
    <dbReference type="InParanoid" id="Q5CQT8"/>
    <dbReference type="OMA" id="NTCIGHI"/>
    <dbReference type="OrthoDB" id="339515at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="19"/>
            <end position="32"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="199" mass="22923" checksum="AD7239F51894B06A" modified="2005-04-12" version="1">MVSDGSSYYSEDSERSLTSEEENFSEGSWEDEEDAEYIFNSREVFGLKLIADDKKTIKPLDNGEFHVDGSDGVSRWIRVMIDSSIQTEHKKVIEEILNNVFQGFGVSKDSSKIEFPAKIKIKNKKTGIEECLILDFQLPRGDEILLAETPSESKPVVNSLMSHLYIYKYNEDGLKFKNYHKDQKVDDGFGFKTWHKYSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR56</accession>
    <name>Q5CR56_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Vacuolar import/degradation Vid27 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625796.1">
        <property type="nucleotide sequence ID" value="XM_625796.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR56"/>
    <dbReference type="STRING" id="353152.Q5CR56"/>
    <dbReference type="GeneID" id="3372962"/>
    <dbReference type="KEGG" id="cpv:cgd4_2020"/>
    <dbReference type="InParanoid" id="Q5CR56"/>
    <dbReference type="OMA" id="NCICELA"/>
    <dbReference type="OrthoDB" id="10251113at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040458">
        <property type="entry name" value="Vid27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013863">
        <property type="entry name" value="VID27_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31913:SF0">
        <property type="entry name" value="VACUOLAR IMPORT AND DEGRADATION PROTEIN 27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08553">
        <property type="entry name" value="VID27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vacuolar import/degradation Vid27 C-terminal" evidence="2">
        <location>
            <begin position="321"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="663" mass="76369" checksum="8BFEBB29A929303F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR63</accession>
    <name>Q5CR63_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RPR46-like RNAse PH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_1950</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625789.1">
        <property type="nucleotide sequence ID" value="XM_625789.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR63"/>
    <dbReference type="STRING" id="353152.Q5CR63"/>
    <dbReference type="GeneID" id="3372762"/>
    <dbReference type="KEGG" id="cpv:cgd4_1950"/>
    <dbReference type="InParanoid" id="Q5CR63"/>
    <dbReference type="OMA" id="CIINEQG"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF1">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP46"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0271">Exosome</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="6">
        <location>
            <begin position="20"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="244" mass="27173" checksum="BD643197EB33E4B6" modified="2005-04-12" version="1" fragment="single">VSFKLMVIRYDGRTNLECGAISANVGIFNSLNGSAEFSIGLSKVIATVWRPEEASSNKCKSYLEVILRPRIGQPQESHKLIEYHILRLFEKVIDFNSFSRCVISITLQIVSEDGPILPVCINAAVLALIDLGIPMEFFPLAVSIAESSHFYGERDISHLMLDPTQSEFEQCISCSTIVINTTEKNIFSCITNKGTGISHNELLDEIHPISLSIATSNSLIRHLSEILLDNIKCKVVRPYNNNLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR81</accession>
    <name>Q5CR81_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Altered inheritance of mitochondria protein 24, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_1770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625771.1">
        <property type="nucleotide sequence ID" value="XM_625771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR81"/>
    <dbReference type="GeneID" id="3372907"/>
    <dbReference type="KEGG" id="cpv:cgd4_1770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1770"/>
    <dbReference type="InParanoid" id="Q5CR81"/>
    <dbReference type="OMA" id="WIASPRI"/>
    <dbReference type="OrthoDB" id="336104at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="242" mass="27424" checksum="F0B5496B356C09C2" modified="2005-04-12" version="1">MQNLEQEIVDRSSTNNTNNREEIEINAENIISVIPRSIVDGSKLILRLKKDEKLSYESPTRILFSNKQLKLERSIWWLTDVILTEPSLIVLDSCSSGMKFFPVPMKKFGTLYSREGVGHVVTGDIIRSRICSRSIPYRNCNKFEHAPRNIGNLRDVNSSDNEDEDIDIVYLRGDESIIRYTLQPNEQIELGAGTVIAWTSGVSFNFKSFCFMKFVTSIVGDSSSISTVWIANSGSKMLYQHG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRG5</accession>
    <name>Q5CRG5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626221.1">
        <property type="nucleotide sequence ID" value="XM_626221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRG5"/>
    <dbReference type="GeneID" id="3373236"/>
    <dbReference type="KEGG" id="cpv:cgd5_2850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2850"/>
    <dbReference type="InParanoid" id="Q5CRG5"/>
    <dbReference type="OMA" id="KEICQTH"/>
    <dbReference type="OrthoDB" id="343848at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="304"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="379"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="457"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="308"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="340"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="393"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="472"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="493"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="603"/>
            <end position="630"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="671" mass="77323" checksum="39EF5F972BE1D345" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRK0</accession>
    <name>Q5CRK0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Protein YIPF</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87971.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626186.1">
        <property type="nucleotide sequence ID" value="XM_626186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRK0"/>
    <dbReference type="STRING" id="353152.Q5CRK0"/>
    <dbReference type="GeneID" id="3373153"/>
    <dbReference type="KEGG" id="cpv:cgd5_2490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2490"/>
    <dbReference type="InParanoid" id="Q5CRK0"/>
    <dbReference type="OMA" id="FCYSISI"/>
    <dbReference type="OrthoDB" id="10256463at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039765">
        <property type="entry name" value="Yip5/YIPF1/YIPF2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12822:SF2">
        <property type="entry name" value="PROTEIN YIPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="238"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="300"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87971.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="320" mass="36676" checksum="4C70D9B5411A0C31" modified="2005-04-12" version="1">MNVDDLNFNIETVNLDSELEFETFDRKTHVESQPLKNSGYLGRIDEFEPGTSIGGEIGQSYMSGQTQKGLEGEDLVSRFLGWFNPVNWQVLKGHFNVTTEEIKQRLISIALVTFSKKSILKNINTFMTNIKNPAISGISVFPHKGQNDLFENGFELFYCKSLDQNKRSDLYGPFWLNITMAMLIGTYSTILPHLKSKYVLNPDITRLTMSFSYIFTSLAITCSVIYGILLYNRENLPITLIFTIYGYSSLTYFPGILLIILFNHTILNWIFLTISSLFNMMFLYNSLFINGSRTHTHLNVALCVIIPNILHIILLKFLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRL6</accession>
    <name>Q5CRL6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Actin-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_2330</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the actin family. ARP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626170.1">
        <property type="nucleotide sequence ID" value="XM_626170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRL6"/>
    <dbReference type="SMR" id="Q5CRL6"/>
    <dbReference type="FunCoup" id="Q5CRL6">
        <property type="interactions" value="78"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRL6"/>
    <dbReference type="GeneID" id="3373122"/>
    <dbReference type="KEGG" id="cpv:cgd5_2330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2330"/>
    <dbReference type="InParanoid" id="Q5CRL6"/>
    <dbReference type="OMA" id="YTTWTGG"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="CDD" id="cd10216">
        <property type="entry name" value="ASKHA_NBD_Arp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000188">
        <property type="entry name" value="Actin like 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000007">
        <property type="entry name" value="Actin like 7B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00190">
        <property type="entry name" value="ACTIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="395" mass="43690" checksum="F175C11E39C350D7" modified="2005-04-12" version="1">MATLHYDDVITSQPAIIDNGSGTIKCGFAGEEAPRVIVNSYVGRPKYKRCMAGALEGDIFVGSKCTENRGILSISHPITNGIITDWYDMEALWTYCFSEMKTSSEDHPVLLTEAALNPRKHREKMAEVFFEVYRVPALFISTQAVLSLYSSGRTTGVVLDSGDGVTHAVPIYQGFALSNAITRSEIAGRNITEYLNLQLRIAGTVFHTKSEMEIVKDIKETACFVSSNIQKDENDENQMGNSTFDAVTSSGNRVASGYPYKLPDGQVIYLGKERFRAPELLFQPSLIGYEYPGIHEVLTHTINKCDLEIRRSLASQIVLAGGSTMFPGLGDRLLFELRKALPKDVKIRINASSDRNLLPWIGGSILGSLATFKTIWISKQEFMEEGPNIVHSKTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRM1</accession>
    <name>Q5CRM1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626165.1">
        <property type="nucleotide sequence ID" value="XM_626165.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRM1"/>
    <dbReference type="GeneID" id="3373120"/>
    <dbReference type="KEGG" id="cpv:cgd5_2280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2280"/>
    <dbReference type="InParanoid" id="Q5CRM1"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="63"/>
            <end position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="209" mass="23537" checksum="6AF339F5867A0CB0" modified="2005-04-12" version="1">MMIINENNSNISINYKISCKDNHVSMSNLLSSNLYVLKEKVLWIGNLEISFNSTKLANYSNGIIFTILILSLLISAPILGLLAVAIKSIIKRFDSREISHLRIPLTENVNTKFKNTLEAGRQSKYNEGEKYPIRTLEIPFRLKKDFISPLSSPVSSQADISRSLYNQLQSPDQIELFTAISNNISSESIQYNTDTCSSPSTIKSITFKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRN2</accession>
    <name>Q5CRN2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein with signal peptide and 8 transmembrane domains possible ZIP zinc transporter family member</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_2150</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626154.1">
        <property type="nucleotide sequence ID" value="XM_626154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRN2"/>
    <dbReference type="FunCoup" id="Q5CRN2">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRN2"/>
    <dbReference type="GeneID" id="3373113"/>
    <dbReference type="KEGG" id="cpv:cgd5_2150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2150"/>
    <dbReference type="InParanoid" id="Q5CRN2"/>
    <dbReference type="OMA" id="IFIECVA"/>
    <dbReference type="OrthoDB" id="448280at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005385">
        <property type="term" value="F:zinc ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003689">
        <property type="entry name" value="ZIP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040">
        <property type="entry name" value="ZINC/IRON TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11040:SF140">
        <property type="entry name" value="ZRT (ZRT), IRT- (IRT-) LIKE PROTEIN TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02535">
        <property type="entry name" value="Zip"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="44"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="74"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="207"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="233"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="265"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="292"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="325"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="353" mass="38110" checksum="292E2709CBD4CBA3" modified="2005-04-12" version="1">MDLFWHKFTCSILLLISAILGYFFPAKIDNDEKNKGRKSKILPIMTAFGAGAFIALALVHLIPDAIEDSSSGLLSFKIAGIEVNCVCHLILLGFLFSIIFESIADEYFGSNGIHGHSHTRHNTDSNHMKDNINSNMMSTNVSSEYSSDEDSCIIDKFGTDLTAGRENSSLCISGSINKNPTLSSKKARVNLAENDNGLKAELGKSSVGFVLVCALFFHSLFEGMVVGTSKSIMGTWMITCVIFAHKWIEILIVYMTLISKGINPLAYIIILSFGSPLGAMIGAIVIISNSVASAVCSALAAGTILYVACIEVIPDVFNDKHSIRTLIKLGSFVTGILTVSTITLVSEIVENSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRQ8</accession>
    <name>Q5CRQ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">GPI1/PIG-Q like N-acetylglucosaminyl-phosphatidylinositol transferase involved in GIP anchor biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626128.1">
        <property type="nucleotide sequence ID" value="XM_626128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRQ8"/>
    <dbReference type="STRING" id="353152.Q5CRQ8"/>
    <dbReference type="GeneID" id="3373108"/>
    <dbReference type="KEGG" id="cpv:cgd5_1850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1850"/>
    <dbReference type="InParanoid" id="Q5CRQ8"/>
    <dbReference type="OMA" id="INCAIFL"/>
    <dbReference type="OrthoDB" id="70250at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007720">
        <property type="entry name" value="PigQ/GPI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329:SF3">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21329">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05024">
        <property type="entry name" value="Gpi1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="431"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="482"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="508"/>
            <end position="535"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="670" mass="77353" checksum="24237BA2B3C74464" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRS8</accession>
    <name>Q5CRS8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">CW-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_1620</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626108.1">
        <property type="nucleotide sequence ID" value="XM_626108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRS8"/>
    <dbReference type="GeneID" id="3373091"/>
    <dbReference type="KEGG" id="cpv:cgd5_1620"/>
    <dbReference type="InParanoid" id="Q5CRS8"/>
    <dbReference type="OMA" id="ANEQNFL"/>
    <dbReference type="OrthoDB" id="757982at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055300">
        <property type="entry name" value="CWZF3/5/7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011124">
        <property type="entry name" value="Znf_CW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46524">
        <property type="entry name" value="CW-TYPE ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46524:SF7">
        <property type="entry name" value="CW-TYPE ZINC FINGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07496">
        <property type="entry name" value="zf-CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51050">
        <property type="entry name" value="ZF_CW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CW-type" evidence="5">
        <location>
            <begin position="25"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="453"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="763"/>
            <end position="824"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="904"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="478"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="805"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="907"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="924" mass="106429" checksum="FBD30350E3359EF5" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRT7</accession>
    <name>Q5CRT7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_1520</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88097.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626099.1">
        <property type="nucleotide sequence ID" value="XM_626099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRT7"/>
    <dbReference type="GeneID" id="3373023"/>
    <dbReference type="KEGG" id="cpv:cgd5_1520"/>
    <dbReference type="InParanoid" id="Q5CRT7"/>
    <dbReference type="OrthoDB" id="10476023at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88097.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="111" mass="12459" checksum="0F29E80F61AFDD78" modified="2005-04-12" version="1">MKLNLEISGNIHTIEQGLKQSSLNSTLNSINNTASEELTKGMLGYVSKHTLTNFKNPKDLEKNVLEHRNSSDLEINSYNTTNNNSTSEIKMSLTNENEIKKKIIEIPLLQA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRX7</accession>
    <name>Q5CRX7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Phospholipid/glycerol acyltransferase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd5_1080</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626059.1">
        <property type="nucleotide sequence ID" value="XM_626059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRX7"/>
    <dbReference type="STRING" id="353152.Q5CRX7"/>
    <dbReference type="GeneID" id="3373297"/>
    <dbReference type="KEGG" id="cpv:cgd5_1080"/>
    <dbReference type="InParanoid" id="Q5CRX7"/>
    <dbReference type="OMA" id="KTYWLPK"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008374">
        <property type="term" value="F:O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07991">
        <property type="entry name" value="LPLAT_LPCAT1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045252">
        <property type="entry name" value="LPCAT1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF52">
        <property type="entry name" value="LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="9 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="11" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="20"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="82"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="114"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="329"/>
            <end position="353"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="14">
        <location>
            <begin position="172"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK88250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="446" mass="51484" checksum="65DF4E5C6A5F2FF2" modified="2005-04-12" version="1" fragment="single">LYFMSLHTLLENISFVFKIYAGLSAFSVLWFTYSYNVYIKRSPNKLKNINQSKFSFCERLDHENISLLYSVLGSILYCPLRIFVLCLTTIVVITILLALKLIGSIFPWMNEAHLYNYIHILIVKFVGFFTLRLLGVLEVDHFVLEKNGIDDSGKIKYSYQKSDGLPAIDDIVTIVSNHISILDISFFMRYVSCGFVAQKEIRENYIFGTVADIIGCIYVDRSCMETRSKAKHLIQDRQLRRFELVQSRASETIICSEKAKDSKCLLFRSEINKHLNSLEKTPLVIFPEGTTTNGSSIIPFKLGAFESLTPVTPVVLLYKYSAFSPAFDIIPFWVLICLLFCNYGKITLSAYWLPQMHAIELNNKEISTKEFADRVRKLMIEVLREAEEFKSEGYLWVSQKKNSHIDTKKNFRKRFEISTSKNLDSSNLTTTGSLRLKQEYIRMLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS75</accession>
    <name>Q5CS75_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_3810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628192.1">
        <property type="nucleotide sequence ID" value="XM_628192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS75"/>
    <dbReference type="STRING" id="353152.Q5CS75"/>
    <dbReference type="GeneID" id="3371508"/>
    <dbReference type="KEGG" id="cpv:cgd1_3810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3810"/>
    <dbReference type="InParanoid" id="Q5CS75"/>
    <dbReference type="OMA" id="ISKSIMF"/>
    <dbReference type="OrthoDB" id="340562at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="912" mass="102438" checksum="D9D64BEAE07E8F7B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS85</accession>
    <name>Q5CS85_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Acetyl-coenzyme A synthetase</fullName>
            <ecNumber evidence="5">6.2.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_3710</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>acetate + ATP + CoA = acetyl-CoA + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23176"/>
            <dbReference type="ChEBI" id="CHEBI:30089"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.2.1.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.2.1.1" evidence="5"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628182.1">
        <property type="nucleotide sequence ID" value="XM_628182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS85"/>
    <dbReference type="FunCoup" id="Q5CS85">
        <property type="interactions" value="159"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS85"/>
    <dbReference type="GeneID" id="3371515"/>
    <dbReference type="KEGG" id="cpv:cgd1_3710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3710"/>
    <dbReference type="InParanoid" id="Q5CS85"/>
    <dbReference type="OMA" id="INVSYNC"/>
    <dbReference type="OrthoDB" id="1706066at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003987">
        <property type="term" value="F:acetate-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016208">
        <property type="term" value="F:AMP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019427">
        <property type="term" value="P:acetyl-CoA biosynthetic process from acetate"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05966">
        <property type="entry name" value="ACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12780:FF:000001">
        <property type="entry name" value="Acetyl-coenzyme A synthetase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011904">
        <property type="entry name" value="Ac_CoA_lig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032387">
        <property type="entry name" value="ACAS_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025110">
        <property type="entry name" value="AMP-bd_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045851">
        <property type="entry name" value="AMP-bd_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02188">
        <property type="entry name" value="Ac_CoA_lig_AcsA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001208">
        <property type="entry name" value="PRK00174.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24095:SF14">
        <property type="entry name" value="ACETYL-COENZYME A SYNTHETASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16177">
        <property type="entry name" value="ACAS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13193">
        <property type="entry name" value="AMP-binding_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 5" id="KW-0436">Ligase</keyword>
    <keyword evidence="3 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Acetyl-coenzyme A synthetase N-terminal" evidence="9">
        <location>
            <begin position="62"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="7">
        <location>
            <begin position="121"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-binding enzyme C-terminal" evidence="8">
        <location>
            <begin position="568"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="9"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361147"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="695" mass="78015" checksum="ADF9AEE4F5E352B6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSA0</accession>
    <name>Q5CSA0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mucin-like low complexity glycoprotein with a signal peptide and an apple domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_3550</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88303.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628167.1">
        <property type="nucleotide sequence ID" value="XM_628167.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSA0"/>
    <dbReference type="STRING" id="353152.Q5CSA0"/>
    <dbReference type="GeneID" id="3371574"/>
    <dbReference type="KEGG" id="cpv:cgd1_3550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3550"/>
    <dbReference type="InParanoid" id="Q5CSA0"/>
    <dbReference type="OMA" id="FEYLSAP"/>
    <dbReference type="OrthoDB" id="342002at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="SMART" id="SM00223">
        <property type="entry name" value="APPLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Apple" evidence="4">
        <location>
            <begin position="331"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="509"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="590"/>
            <end position="694"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="594"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="604"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="634"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88303.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="925" mass="103836" checksum="A8FB6EF39830E91B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSD6</accession>
    <name>Q5CSD6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cyclin'cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628131.1">
        <property type="nucleotide sequence ID" value="XM_628131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSD6"/>
    <dbReference type="GeneID" id="3371467"/>
    <dbReference type="KEGG" id="cpv:cgd1_3150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3150"/>
    <dbReference type="InParanoid" id="Q5CSD6"/>
    <dbReference type="OrthoDB" id="338366at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="1">
        <location>
            <begin position="88"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="327" mass="38377" checksum="C094D2420C43D91A" modified="2005-04-12" version="1">MIKIYSKLKDENEETSNSLSNFRKKNVSKIGRNLTSNISRFYKTLYEENYLRIISEEIFDFQSLKDINGLNLDSFNDFVMSIKSPYIKSIESIPYFDQKHNIGSNERFKIIYWLSLHSNRLKFQSCTFHLSCRIFDTFLIETHVQYNNSELAATAAACFLLASNIIETVSDMIVPSIRQFCNAAKWLNPDKILKRQLEILTHVNTSFGINYTPSKLLYIYISRIKYHSILSKEFLHLYRNGEIIRIFDSSLAICDLLQYTPLPTTKNGQSLISIIPCFILWAKLETYIIFNEFDCQYIQNLFFKEICSLNNYLCKEIVNIIYQITKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSE0</accession>
    <name>Q5CSE0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Gamma tubulin complex component C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_3110</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628127.1">
        <property type="nucleotide sequence ID" value="XM_628127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSE0"/>
    <dbReference type="GeneID" id="3371470"/>
    <dbReference type="KEGG" id="cpv:cgd1_3110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3110"/>
    <dbReference type="InParanoid" id="Q5CSE0"/>
    <dbReference type="OMA" id="FESKHIC"/>
    <dbReference type="OrthoDB" id="341600at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="4" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="587"/>
            <end position="844"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="845" mass="99447" checksum="DD1DB41BF490D53B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSG5</accession>
    <name>Q5CSG5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mediator of RNA polymerase II transcription subunit 7</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_2800</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the Mediator complex subunit 7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628102.1">
        <property type="nucleotide sequence ID" value="XM_628102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSG5"/>
    <dbReference type="STRING" id="353152.Q5CSG5"/>
    <dbReference type="GeneID" id="3371721"/>
    <dbReference type="KEGG" id="cpv:cgd1_2800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2800"/>
    <dbReference type="InParanoid" id="Q5CSG5"/>
    <dbReference type="OMA" id="LESPPCI"/>
    <dbReference type="OrthoDB" id="10253553at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070847">
        <property type="term" value="C:core mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037212">
        <property type="entry name" value="Med7/Med21-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009244">
        <property type="entry name" value="Mediatior_Med7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044888">
        <property type="entry name" value="Mediatior_Med7_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21428:SF11">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05983">
        <property type="entry name" value="Med7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140718">
        <property type="entry name" value="Mediator hinge subcomplex-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0010">Activator</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0804">Transcription</keyword>
    <keyword evidence="3 6" id="KW-0805">Transcription regulation</keyword>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="125"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU364060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="173" mass="19753" checksum="81D60D5D8B1D8DC3" modified="2005-04-12" version="1">MDNANGQQNIVSSFPPPPPYFRLFDHEDKVAKIKPPPCIEGPFTCFGSQLSSDISIHPLDSDTILYNESNVDLPAELMMLNEMFQMEILKLLENSGKGVVDTSSVKKIIKIYNNMNHILEKLRIIQTYHQICDELEAQVNEKNQLLDQMKQHLEEYKSLLDDLSKENSGKLSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSG7</accession>
    <name>Q5CSG7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 16">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="5 16">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">cgd1_2770</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 16">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="14">In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Apicoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 15">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="5 16"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628100.1">
        <property type="nucleotide sequence ID" value="XM_628100.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CSG7">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSG7"/>
    <dbReference type="GeneID" id="3371722"/>
    <dbReference type="KEGG" id="cpv:cgd1_2770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2770"/>
    <dbReference type="InParanoid" id="Q5CSG7"/>
    <dbReference type="OMA" id="FFGVVHY"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020011">
        <property type="term" value="C:apicoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000006">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009674">
        <property type="entry name" value="Rpa2_dom_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06883">
        <property type="entry name" value="RNA_pol_Rpa2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0933">Apicoplast</keyword>
    <keyword evidence="7 16" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="10 16" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12 16" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 16" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="19">
        <location>
            <begin position="13"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="20">
        <location>
            <begin position="480"/>
            <end position="543"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase I subunit RPA2" evidence="21">
        <location>
            <begin position="619"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="17">
        <location>
            <begin position="760"/>
            <end position="1165"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="18">
        <location>
            <begin position="1167"/>
            <end position="1272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00026088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="Pfam" id="PF06883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EAK88354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1281" mass="143589" checksum="00122D0ED28DD1BC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSH8</accession>
    <name>Q5CSH8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_2630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628089.1">
        <property type="nucleotide sequence ID" value="XM_628089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSH8"/>
    <dbReference type="FunCoup" id="Q5CSH8">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSH8"/>
    <dbReference type="GeneID" id="3371484"/>
    <dbReference type="KEGG" id="cpv:cgd1_2630"/>
    <dbReference type="InParanoid" id="Q5CSH8"/>
    <dbReference type="OMA" id="KCENIVI"/>
    <dbReference type="OrthoDB" id="347657at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050236">
        <property type="entry name" value="Ser_Thr_kinase_AGC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356:SF163">
        <property type="entry name" value="3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24356">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="31"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="410" mass="47265" checksum="3506A15AFE53FCBE" modified="2005-04-12" version="1" fragment="single">IMKRGFLKNLVNKRSYEQKKNETLKVEIDDFELFELIGTGNFTQVFRAFDIVNKTYVAIKVANKSQLRALKKEGEILNEKKICTKLNNSRSRNVIKLLNSFANEENVYLVYELCTDGELWQKILPIGIKPLRQAVYYLAQLLIAIEDIHNLNIVHRDIKAENCLLMKNGQLKLADFGSSIHLDDVVCNSQNCGSSCECRFTINRGRREFKYFVGTPQFMAPETIRNKPPTKAVDLWSFGCTVFQVICGYPPFNAPSEFLVFCRVFQNGLRFPPDFPKDAKLLVESLLKQEPSERATIEEVKKSKFFEDVNFRELISEKEYLNFPPSLKDLCLIQVAKSYEKYKTEDLEKLNALDDSDTILGRLRFEAERKEYEGPRDTWQSEFCDQIFNENISGNTNNCTSSSSSESNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSM5</accession>
    <name>Q5CSM5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_2070</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628042.1">
        <property type="nucleotide sequence ID" value="XM_628042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSM5"/>
    <dbReference type="GeneID" id="3371648"/>
    <dbReference type="KEGG" id="cpv:cgd1_2070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2070"/>
    <dbReference type="InParanoid" id="Q5CSM5"/>
    <dbReference type="OMA" id="CTNINTV"/>
    <dbReference type="OrthoDB" id="343562at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="499" mass="58062" checksum="3139D3128E17BB70" modified="2005-04-12" version="1">MLENDFPHNELVWWRMTRKQRYLPGRTVTLELENKTVGIEEEHEKLLMKLVKQGSVIIHSFDDMKYAVCSSSNVRLYPALSEQEQKSLEKECIRSTKMNYRALLRIKKIVELRKLDQAQFENSETNMSLLEIRMIQFFKDRDSITNISESIEYLENNTAIELLGAIVNRKTLKTMIGQSPQAFFYLDKTIFNEKSKHLSEKEDISVGSIDSKHWQNELNEIIVNRKTICELLSCIPFELLSSSHNGKNNIELMAGRIFVNDPEDSLIEEFCEKSIDAIYRGKFIMEYIKLSILYLRVLSKSIALRVVSANKKKNTRQRSILEYVVVLSLELLFCDPYEAKMLSLTKLKHEETSISNVNNCLVSLSIDIDSNNSSKKMPENISKAEKSNVHGLLLNFKTTVPSRDSKENELYYKVDLNRISSQLAISEELQNAYSYYNKKFTLKELEHRTKSFHVIKTSCPIMIKLLREWILNANRGEFDHIDSIDQLKKIKENLLNVDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSP6</accession>
    <name>Q5CSP6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted integral membrane protein, 4 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628021.1">
        <property type="nucleotide sequence ID" value="XM_628021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSP6"/>
    <dbReference type="GeneID" id="3371628"/>
    <dbReference type="KEGG" id="cpv:cgd1_1820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1820"/>
    <dbReference type="InParanoid" id="Q5CSP6"/>
    <dbReference type="OMA" id="CAVITSC"/>
    <dbReference type="OrthoDB" id="337182at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="75"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="107"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="192" mass="21842" checksum="C661EB8D0000FA47" modified="2005-04-12" version="1">MIVWSSLFFTIDEEQFIGLYNIIFPLCKLINYFIILQVLIGAISLFYLNNQILGLLEIFFFVGNGIVTTHLQVPILYIIYSITSIIGCLVHFFNAEIQNATLSDLNFISFISGITNHFCCSILSLKIFLLLINNIDWESKIMSMGGNLHIAYIGYPRFNNSTSNIGYYMPLEEGLNNIEPKELLSSTTEINL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSV6</accession>
    <name>Q5CSV6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ubiquitin carboxyl-terminal hydrolase</fullName>
            <ecNumber evidence="8">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_1170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 12">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7 8">Belongs to the peptidase C12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627961.1">
        <property type="nucleotide sequence ID" value="XM_627961.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSV6"/>
    <dbReference type="FunCoup" id="Q5CSV6">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSV6"/>
    <dbReference type="GeneID" id="3371365"/>
    <dbReference type="KEGG" id="cpv:cgd1_1170"/>
    <dbReference type="InParanoid" id="Q5CSV6"/>
    <dbReference type="OMA" id="XAKEKQN"/>
    <dbReference type="OrthoDB" id="1924260at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.860">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.532.10">
        <property type="entry name" value="Peptidase C12, ubiquitin carboxyl-terminal hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001578">
        <property type="entry name" value="Peptidase_C12_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036959">
        <property type="entry name" value="Peptidase_C12_UCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041507">
        <property type="entry name" value="UCH_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10589:SF16">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE ISOZYME L5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01088">
        <property type="entry name" value="Peptidase_C12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18031">
        <property type="entry name" value="UCH_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00707">
        <property type="entry name" value="UBCTHYDRLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52048">
        <property type="entry name" value="UCH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 7 8" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 7 8" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4 7 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="UCH catalytic" evidence="9">
        <location>
            <begin position="28"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="7">
        <location>
            <position position="113"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="7">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="7">
        <location>
            <position position="107"/>
        </location>
    </feature>
    <feature type="site" description="Important for enzyme activity" evidence="7">
        <location>
            <position position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01393"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361215"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="398" mass="45502" checksum="C5CDCD366EEE60EC" modified="2005-04-12" version="1" fragment="single">YKYKYIYIHIYLYANKLVNLIFEIMSGDWCTIESDPGVFTELVERYGVKGIQFAEIYDYSESGMEFIANEYGNIYGIIFLFKFTEKFKGNHFSQPIEAPPGMFYANQVINNACATQAILSIILNRLDIDIGSHLEEFKKFSSSFDPMTKGLVIGNSEVLRTAHNSFRPISSLEVSDPDSNDSKGDAFHYICYIPFGKNVYELDGLTTGVVDLGSPKVNDSENFSLDNEISALYDKPNLWVSRVMEEVKRRIELQNEDSSHGEIRFSLLAVVPDKISVTEKKVKYLKISRQAHIAKLLSLGGDLSTDLESLSEEEIESDELDSILSSIPNDIALIQKEITKITHEISENLSIIQNEKYNREIWKKENERRRHDFLPFVLTLLRHASKKGLLMKKLSQLQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSV8</accession>
    <name>Q5CSV8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_1150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627959.1">
        <property type="nucleotide sequence ID" value="XM_627959.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSV8"/>
    <dbReference type="GeneID" id="3371605"/>
    <dbReference type="KEGG" id="cpv:cgd1_1150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1150"/>
    <dbReference type="InParanoid" id="Q5CSV8"/>
    <dbReference type="OrthoDB" id="335744at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="126" mass="14266" checksum="5FC6B06681F48F3A" modified="2005-04-12" version="1">MCNNNFFCFESYPANNRRCSCCCFDLRRGCSQQLMCTNRRPVVHRYICRICIPRVNRMPALQNRNTCFECSACGQKAGTAPIQSQKPEVLDKCEHNQSCSHNQGPIQKNPTGGCRCGECCIVFCGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="123" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSZ3</accession>
    <name>Q5CSZ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="17">Dynein heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">cgd1_750</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the dynein heavy chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627924.1">
        <property type="nucleotide sequence ID" value="XM_627924.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CSZ3">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSZ3"/>
    <dbReference type="GeneID" id="3371535"/>
    <dbReference type="KEGG" id="cpv:cgd1_750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_750"/>
    <dbReference type="InParanoid" id="Q5CSZ3"/>
    <dbReference type="OMA" id="CAWLRGL"/>
    <dbReference type="OrthoDB" id="424310at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005929">
        <property type="term" value="C:cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030286">
        <property type="term" value="C:dynein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045505">
        <property type="term" value="F:dynein intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051959">
        <property type="term" value="F:dynein light intermediate chain binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008569">
        <property type="term" value="F:minus-end-directed microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.920.20:FF:000002">
        <property type="entry name" value="Cytoplasmic dynein 1 heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000071">
        <property type="entry name" value="Cytoplasmic dynein heavy chain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.710:FF:000001">
        <property type="entry name" value="Dynein axonemal heavy chain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.140.100:FF:000001">
        <property type="entry name" value="dynein heavy chain 17, axonemal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002357">
        <property type="entry name" value="Glutathione S-transferase class-mu 26 kDa isozyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.2620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1220">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1120">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.490.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1060">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.100">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.180.20">
        <property type="entry name" value="Dynein heavy chain, N-terminal domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.720">
        <property type="entry name" value="Region D6 of dynein motor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035699">
        <property type="entry name" value="AAA_6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035706">
        <property type="entry name" value="AAA_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041658">
        <property type="entry name" value="AAA_lid_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042219">
        <property type="entry name" value="AAA_lid_11_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026983">
        <property type="entry name" value="DHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054354">
        <property type="entry name" value="DYNC2H1-like_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042222">
        <property type="entry name" value="Dynein_2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043157">
        <property type="entry name" value="Dynein_AAA1S"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041466">
        <property type="entry name" value="Dynein_AAA5_ext"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041228">
        <property type="entry name" value="Dynein_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043160">
        <property type="entry name" value="Dynein_C_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024743">
        <property type="entry name" value="Dynein_HC_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024317">
        <property type="entry name" value="Dynein_heavy_chain_D4_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004273">
        <property type="entry name" value="Dynein_heavy_D6_P-loop"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013602">
        <property type="entry name" value="Dynein_heavy_linker"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013594">
        <property type="entry name" value="Dynein_heavy_tail"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042228">
        <property type="entry name" value="Dynein_linker_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703">
        <property type="entry name" value="DYNEIN HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45703:SF36">
        <property type="entry name" value="DYNEIN HEAVY CHAIN, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12774">
        <property type="entry name" value="AAA_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12775">
        <property type="entry name" value="AAA_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12780">
        <property type="entry name" value="AAA_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12781">
        <property type="entry name" value="AAA_9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18198">
        <property type="entry name" value="AAA_lid_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08385">
        <property type="entry name" value="DHC_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08393">
        <property type="entry name" value="DHC_N2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22597">
        <property type="entry name" value="DYN_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17852">
        <property type="entry name" value="Dynein_AAA_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18199">
        <property type="entry name" value="Dynein_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03028">
        <property type="entry name" value="Dynein_heavy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12777">
        <property type="entry name" value="MT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="13" id="KW-0966">Cell projection</keyword>
    <keyword evidence="10" id="KW-0969">Cilium</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="12" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-0243">Dynein</keyword>
    <keyword evidence="5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="11" id="KW-0505">Motor protein</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2168"/>
            <end position="2303"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2459"/>
            <end position="2847"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="2891"/>
            <end position="3043"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="16">
        <location>
            <begin position="3276"/>
            <end position="3742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="993"/>
            <end position="1015"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1576"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="2653"/>
            <end position="2701"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="4245"/>
            <end position="4267"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3582"/>
            <end position="3634"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="3814"/>
            <end position="3848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="998"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1596"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="2670"/>
            <end position="2679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAK88498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="5246" mass="595649" checksum="28F5652E4F3C8F37" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT79</accession>
    <name>Q5CT79_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">YawG/Kre35p-like, Yjeq GTpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_4090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626590.1">
        <property type="nucleotide sequence ID" value="XM_626590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT79"/>
    <dbReference type="FunCoup" id="Q5CT79">
        <property type="interactions" value="320"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT79"/>
    <dbReference type="GeneID" id="3373693"/>
    <dbReference type="KEGG" id="cpv:cgd2_4090"/>
    <dbReference type="InParanoid" id="Q5CT79"/>
    <dbReference type="OMA" id="WETNDLE"/>
    <dbReference type="OrthoDB" id="61815at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01857">
        <property type="entry name" value="HSR1_MMR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030378">
        <property type="entry name" value="G_CP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043358">
        <property type="entry name" value="GNL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709:SF2">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45709">
        <property type="entry name" value="LARGE SUBUNIT GTPASE 1 HOMOLOG-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01926">
        <property type="entry name" value="MMR_HSR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51721">
        <property type="entry name" value="G_CP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CP-type G" evidence="7">
        <location>
            <begin position="179"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="315"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="355"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="666" mass="76851" checksum="67E1375C44CCFD57" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT82</accession>
    <name>Q5CT82_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">PNPLA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_4050</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626587.1">
        <property type="nucleotide sequence ID" value="XM_626587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT82"/>
    <dbReference type="STRING" id="353152.Q5CT82"/>
    <dbReference type="GeneID" id="3373491"/>
    <dbReference type="KEGG" id="cpv:cgd2_4050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4050"/>
    <dbReference type="InParanoid" id="Q5CT82"/>
    <dbReference type="OMA" id="EEWIEIC"/>
    <dbReference type="OrthoDB" id="10049244at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004806">
        <property type="term" value="F:triacylglycerol lipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd07232">
        <property type="entry name" value="Pat_PLPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050301">
        <property type="entry name" value="NTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021771">
        <property type="entry name" value="Triacylglycerol_lipase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226">
        <property type="entry name" value="NEUROPATHY TARGET ESTERASE/SWISS CHEESE D.MELANOGASTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14226:SF10">
        <property type="entry name" value="TRIACYLGLYCEROL LIPASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11815">
        <property type="entry name" value="DUF3336"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 4" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="3 4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="36"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="6">
        <location>
            <begin position="476"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="4">
        <location>
            <begin position="507"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="509"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="4">
        <location>
            <position position="660"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="821" mass="95220" checksum="BDC0C5A5B9C1F715" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTD3</accession>
    <name>Q5CTD3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein with low complexity regions and an apicomplexan specific domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_3490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626536.1">
        <property type="nucleotide sequence ID" value="XM_626536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTD3"/>
    <dbReference type="STRING" id="353152.Q5CTD3"/>
    <dbReference type="GeneID" id="3373755"/>
    <dbReference type="KEGG" id="cpv:cgd2_3490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3490"/>
    <dbReference type="InParanoid" id="Q5CTD3"/>
    <dbReference type="OMA" id="WINQLKH"/>
    <dbReference type="OrthoDB" id="333966at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043565">
        <property type="term" value="F:sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312:SF1">
        <property type="entry name" value="BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTOR A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14312">
        <property type="entry name" value="CREB/ATF BZIP TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="8">
        <location>
            <begin position="341"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="244"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="300"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="676"/>
            <end position="745"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1071"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="954"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="252"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="272"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="676"/>
            <end position="743"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1071"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1105"/>
            <end position="1195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1275" mass="129115" checksum="BFB2BF080B4C7C4D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTH9</accession>
    <name>Q5CTH9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_2930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626490.1">
        <property type="nucleotide sequence ID" value="XM_626490.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTH9"/>
    <dbReference type="GeneID" id="3373464"/>
    <dbReference type="KEGG" id="cpv:cgd2_2930"/>
    <dbReference type="InParanoid" id="Q5CTH9"/>
    <dbReference type="OMA" id="ECIMSIT"/>
    <dbReference type="OrthoDB" id="341531at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="192"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="17"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="345"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="208"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="594" mass="68419" checksum="BAC1878D4F0FCD2C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTK2</accession>
    <name>Q5CTK2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_2650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626467.1">
        <property type="nucleotide sequence ID" value="XM_626467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTK2"/>
    <dbReference type="GeneID" id="3373635"/>
    <dbReference type="KEGG" id="cpv:cgd2_2650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2650"/>
    <dbReference type="InParanoid" id="Q5CTK2"/>
    <dbReference type="OrthoDB" id="342566at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="418" mass="48357" checksum="5CC40D64DB191B7E" modified="2005-04-12" version="1">MQSKNIPYLFFLLHFQNIFTYRRRLTALHLRFKQKKLMKIRKLSLILTLSFMKFFYVFCFDESSNSIKESLLNCLPLKKEKLGKIINGKEIYPLVSLEIKTQQLKLEGEIIPSKIVSRRILIAKGVVQSRLLPNDVLYFNTNTNSNQAVKAKQLVGVVTYGKNNRKEELYSSCDGIIKEVLPQGFHDFEATFFVIYCDLKNPVLSTYFGYSIVPITEKNTVFGKFENAPAKKEMNIKKDKLNDRNTRLISNKEHKKLYFEQSTHHKYNSSLEYQNRQSTHCAGKFQLNSICMNEGDSASSDNSENPSNVKRVEFLYKKCVPNKSKPADSSLTVKLKAYRKSLEALKQSVANITDFSRVGNIKLEDEKQLDFDKQKNLASKMSTLSIKYRIWISFAFTIIILTLIALLRISRYSFTHST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTU0</accession>
    <name>Q5CTU0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative vacuolar protein sorting/targeting protein 26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_1570</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88812.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626379.1">
        <property type="nucleotide sequence ID" value="XM_626379.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTU0"/>
    <dbReference type="SMR" id="Q5CTU0"/>
    <dbReference type="STRING" id="353152.Q5CTU0"/>
    <dbReference type="GeneID" id="3373714"/>
    <dbReference type="KEGG" id="cpv:cgd2_1570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1570"/>
    <dbReference type="InParanoid" id="Q5CTU0"/>
    <dbReference type="OMA" id="FKWKFSS"/>
    <dbReference type="OrthoDB" id="3821113at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030904">
        <property type="term" value="C:retromer complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.640:FF:000015">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.640">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014752">
        <property type="entry name" value="Arrestin-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028934">
        <property type="entry name" value="Vps26-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12233">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 26 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03643">
        <property type="entry name" value="Vps26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88812.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="306" mass="34906" checksum="34078E1DB8017E5D" modified="2005-04-12" version="1">MLSFLSSINACNLELSINQDVGRKSAPLSKNKKGEKGLIFSDGEDISGVAIVAIKPGRKLDHQGIRVEVIGQIDVIYDQSSSYDFFSITKDLEPSGSLFETKQYKWKFNAVDKPYETYYGTNIQLRYFVRLTVLRAYASNIVKEVDFVVQNLSNGIPSSISEKNKIQDGIKMEVGVEGCLHIELEYDKSTYHLKDVVIGKVYFSIVRLKIKYMEIDIIRLETCGSGPTAITETEVLSKFEIMDGAPAKQETIPLRMYLCGCDLTPTYKNLQNKLSVRYFLNLIIVDEEDRRYFKRQEITLWRKKLG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTU9</accession>
    <name>Q5CTU9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Splicing factor U2AF U2 SnRNP auxiliary factor large subunit, RRM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_1480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88821.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626370.1">
        <property type="nucleotide sequence ID" value="XM_626370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTU9"/>
    <dbReference type="STRING" id="353152.Q5CTU9"/>
    <dbReference type="GeneID" id="3373723"/>
    <dbReference type="KEGG" id="cpv:cgd2_1480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1480"/>
    <dbReference type="InParanoid" id="Q5CTU9"/>
    <dbReference type="OMA" id="CEYADIC"/>
    <dbReference type="OrthoDB" id="10266058at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd12232">
        <property type="entry name" value="RRM3_U2AF65"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23139">
        <property type="entry name" value="RNA-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="177"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88821.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="438" mass="50030" checksum="ABF4395817AB4451" modified="2005-04-12" version="1">MNSKPLYELNFLFMDKLNYENKLELKETKWKRNIDESDPAFRTVEFGSDPHVFNSETVEIFLTGVILTILGKASNDSEKLKLIEEVVESDFSSLSCSTGLIANLENSIQIDNIFCVTFTSSLFSLICLKLDGLIIDSQNIKLFCRRPNKYSNLNNEKVLDTFIIPRISQHDNFKENEKCILKNLPTDINEEKIRQHLESIGKLKSLTIIYDPITGIPKGVGSFEFEESSLCKKAIAILHGKPIESTKNGIWNIYLGSGTITNYKSNKGQFNQSNFSVNSNIIQNSEYLHITEIPTSMTYNIFSNPVLGLMMKYSKQVGETPSQIIQLLNIFLPEELVDNEIYNSTLDSVRSEAEVYGTILEIFCPRPKVIEEFHSCSGAGKVFIYFSDITAARRAQYQFNGRVFDNIKTVSATFFPLEKYLKHEYSVISYYDEDQKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUB3</accession>
    <name>Q5CUB3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nop12p nucleolar protein, RRM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_3500</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88991.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626901.1">
        <property type="nucleotide sequence ID" value="XM_626901.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUB3"/>
    <dbReference type="FunCoup" id="Q5CUB3">
        <property type="interactions" value="13"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUB3"/>
    <dbReference type="GeneID" id="3374113"/>
    <dbReference type="KEGG" id="cpv:cgd3_3500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3500"/>
    <dbReference type="InParanoid" id="Q5CUB3"/>
    <dbReference type="OMA" id="KCTDEQM"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017069">
        <property type="term" value="F:snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051183">
        <property type="entry name" value="U1_U11-U12_snRNP_70-35kDa"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13952">
        <property type="entry name" value="U1 SMALL NUCLEAR RIBONUCLEOPROTEIN 70 KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="82"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="190"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="274"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="49"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="296"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="310"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88991.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="349" mass="39304" checksum="19980C2EC6FCC7E9" modified="2005-04-12" version="1">MEKAEKVTSITDIIARNSRSKGATEEINPNIEKLLSECSDNPRILAPKNQEKNRSENVAKEEKPKEFTKVKYDKNNDPRIENTLFVGNVALHISEKELLSKLEIKQGEVESMRFRSLPIHPKFASKKKVGAALECFSGNSSTKNAYIVLKEKERMKPIIDKFSGIVLAGNILRLTPASKGNQFSTFDRKRTVFIGGLPKFCTEDELRRFVTMSLNEDCVHSVRIIKSATTGKPKGFGFVLFNDRKFVISSVKMLSGAQFKDSKISVTRALSEEEAKSKANSNNSRRRMINNGTQSKNKEGDDSMRENRFISKKNAKNKVNKIKKKLKKVVKKAPNIKKASKSKKSKSKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUB7</accession>
    <name>Q5CUB7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RING-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_3460</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88995.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626897.1">
        <property type="nucleotide sequence ID" value="XM_626897.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUB7"/>
    <dbReference type="STRING" id="353152.Q5CUB7"/>
    <dbReference type="GeneID" id="3374117"/>
    <dbReference type="KEGG" id="cpv:cgd3_3460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3460"/>
    <dbReference type="InParanoid" id="Q5CUB7"/>
    <dbReference type="OMA" id="PTHTAHY"/>
    <dbReference type="OrthoDB" id="341679at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014891">
        <property type="entry name" value="DWNN_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08783">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01180">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51282">
        <property type="entry name" value="DWNN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DWNN" evidence="4">
        <location>
            <begin position="3"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="116"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="543"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="543"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="573"/>
            <end position="584"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88995.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="584" mass="64745" checksum="339A69A0F3CE5D4C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUC6</accession>
    <name>Q5CUC6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_3370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626888.1">
        <property type="nucleotide sequence ID" value="XM_626888.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUC6"/>
    <dbReference type="GeneID" id="3374124"/>
    <dbReference type="KEGG" id="cpv:cgd3_3370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3370"/>
    <dbReference type="InParanoid" id="Q5CUC6"/>
    <dbReference type="OMA" id="YRIWIGF"/>
    <dbReference type="OrthoDB" id="340622at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254524" evidence="1">
        <location>
            <begin position="29"/>
            <end position="1507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1507" mass="165852" checksum="EAE94A99424E5C07" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUF3</accession>
    <name>Q5CUF3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative exportin 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_3060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the exportin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89026.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626861.1">
        <property type="nucleotide sequence ID" value="XM_626861.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUF3"/>
    <dbReference type="FunCoup" id="Q5CUF3">
        <property type="interactions" value="594"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUF3"/>
    <dbReference type="GeneID" id="3374090"/>
    <dbReference type="KEGG" id="cpv:cgd3_3060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3060"/>
    <dbReference type="InParanoid" id="Q5CUF3"/>
    <dbReference type="OMA" id="WAFKHNN"/>
    <dbReference type="OrthoDB" id="27218at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005049">
        <property type="term" value="F:nuclear export signal receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006611">
        <property type="term" value="P:protein export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041123">
        <property type="entry name" value="CRM1_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041235">
        <property type="entry name" value="Exp1_repeat_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013598">
        <property type="entry name" value="Exportin-1/Importin-b-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001494">
        <property type="entry name" value="Importin-beta_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045065">
        <property type="entry name" value="XPO1/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014877">
        <property type="entry name" value="XPO1_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040485">
        <property type="entry name" value="XPO1_repeat_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223">
        <property type="entry name" value="EXPORTIN 1/5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11223:SF2">
        <property type="entry name" value="EXPORTIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08767">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18777">
        <property type="entry name" value="CRM1_repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18784">
        <property type="entry name" value="CRM1_repeat_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18787">
        <property type="entry name" value="CRM1_repeat_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03810">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08389">
        <property type="entry name" value="Xpo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01102">
        <property type="entry name" value="CRM1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00913">
        <property type="entry name" value="IBN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50166">
        <property type="entry name" value="IMPORTIN_B_NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Importin N-terminal" evidence="7">
        <location>
            <begin position="39"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1246"/>
            <end position="1266"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1253"/>
            <end position="1266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89026.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1266" mass="146353" checksum="09C62C5C73973370" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUF4</accession>
    <name>Q5CUF4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_3050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626860.1">
        <property type="nucleotide sequence ID" value="XM_626860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUF4"/>
    <dbReference type="GeneID" id="3374092"/>
    <dbReference type="KEGG" id="cpv:cgd3_3050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3050"/>
    <dbReference type="InParanoid" id="Q5CUF4"/>
    <dbReference type="OMA" id="FTHCSSG"/>
    <dbReference type="OrthoDB" id="343590at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="319" mass="36625" checksum="F5B87CFA3F75E586" modified="2005-04-12" version="1">MSIRREEEERRFCQNISPRGCRKENVKKDQLEFEGVDGDEFKDINPVYGCLVPCLKCCIYPCRAFFLTGRCISQKRRMKKAKYSKRKYNNNNAYSYNANNQKPQYNQFYSASSNIGVSPNLQGSINADGSVKGNLRHPTLAGNCITPICSGSSASFCTIQAEYPSNRRSVLPSSSSYGPRRYVEKTVESPIFNEPNKLTCNCLGNSHQEIEFEERYDNIESNSFHKIVDNTLSREIIDENYFIKHSENQSNEFKDFFPENSERECFCIEECFEHNLKDNKAYPNKGNLLTNSIFSSCTPCEYSDHVSLKYSQGNCFVDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUH9</accession>
    <name>Q5CUH9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_2770</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RRN7/TAF1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626835.1">
        <property type="nucleotide sequence ID" value="XM_626835.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUH9"/>
    <dbReference type="GeneID" id="3373963"/>
    <dbReference type="KEGG" id="cpv:cgd3_2770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2770"/>
    <dbReference type="InParanoid" id="Q5CUH9"/>
    <dbReference type="OMA" id="MRISNER"/>
    <dbReference type="OrthoDB" id="340175at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070860">
        <property type="term" value="C:RNA polymerase I core factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001164">
        <property type="term" value="F:RNA polymerase I core promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042790">
        <property type="term" value="P:nucleolar large rRNA transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033599">
        <property type="entry name" value="TAF1B/Rrn7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31576:SF2">
        <property type="entry name" value="TATA BOX-BINDING PROTEIN-ASSOCIATED FACTOR RNA POLYMERASE I SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4" id="KW-0863">Zinc-finger</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="976" mass="114043" checksum="7163448C73279AC8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUI0</accession>
    <name>Q5CUI0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">DNA-directed primase/polymerase protein</fullName>
            <ecNumber evidence="3">2.7.7.102</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_2760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>DNA(n) + a 2'-deoxyribonucleoside 5'-triphosphate = DNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:22508"/>
            <dbReference type="Rhea" id="RHEA-COMP:17339"/>
            <dbReference type="Rhea" id="RHEA-COMP:17340"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61560"/>
            <dbReference type="ChEBI" id="CHEBI:173112"/>
            <dbReference type="EC" id="2.7.7.7"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="4">
            <dbReference type="Rhea" id="RHEA:22509"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="2">
            <text>ssDNA + n NTP = ssDNA/pppN(pN)n-1 hybrid + (n-1) diphosphate.</text>
            <dbReference type="EC" id="2.7.7.102"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.102" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626834.1">
        <property type="nucleotide sequence ID" value="XM_626834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUI0"/>
    <dbReference type="STRING" id="353152.Q5CUI0"/>
    <dbReference type="GeneID" id="3373962"/>
    <dbReference type="KEGG" id="cpv:cgd3_2760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2760"/>
    <dbReference type="InParanoid" id="Q5CUI0"/>
    <dbReference type="OMA" id="HYEVIQD"/>
    <dbReference type="OrthoDB" id="5988181at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042276">
        <property type="term" value="P:error-prone translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006264">
        <property type="term" value="P:mitochondrial DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009411">
        <property type="term" value="P:response to UV"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044917">
        <property type="entry name" value="PRIMPOL"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399">
        <property type="entry name" value="DNA-DIRECTED PRIMASE / POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31399:SF0">
        <property type="entry name" value="DNA-DIRECTED PRIMASE_POLYMERASE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03121">
        <property type="entry name" value="Herpes_UL52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00026139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00044677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00044768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00047303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="502" mass="60115" checksum="D3910A357978E741" modified="2005-04-12" version="1">MDYTQRNLEKTVLDNHHICLNLKRKNKLTSENKDHIYYELLENKYINPYLDQIDYSKIFKRFFSQKDAIEYYDSINSHFGQIENSDDSRILPIGVFAEETTINGSRNYIVSSYESIWNYISSLCKYERHVYEVILANQPCWLYFDIEYNKSQYNLDDNRILIDFTSHLKLWIKLLFGYSIDKKDIIYLCSSNADKFSYHIIIKRIDMVQNFSTLFKDNISMKIFVTHFISFLNKNNVLLDEFDHFNLQNIIDTGVYTRNRCFRMLYSSKFGKKSILQIDEMNTSFVLTEILPIKLFRSMITFLNTRTFSKSNFISRINVINQLCFNLEKFCLPKICGINEISFNEYKSNENTKFIPRHLVKLTEYVILFWNKLSEELQNNPELMLSNLEESKLIDYCLKKINFDFDDKISIRIQMFISTTMYFKEKELIIISVSKLNKLCFNIEREHISNGIKLIIDFYNKRFYQKCFDPDCINFKSRSFTVPESLINYSYDILELSEMIKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUL9</accession>
    <name>Q5CUL9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_2280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89081.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626795.1">
        <property type="nucleotide sequence ID" value="XM_626795.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUL9"/>
    <dbReference type="GeneID" id="3373921"/>
    <dbReference type="KEGG" id="cpv:cgd3_2280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2280"/>
    <dbReference type="InParanoid" id="Q5CUL9"/>
    <dbReference type="OMA" id="DYISNCK"/>
    <dbReference type="OrthoDB" id="341474at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89081.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="551" mass="62929" checksum="32D4D6335372689D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUM3</accession>
    <name>Q5CUM3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_2240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the POMP/UMP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626791.1">
        <property type="nucleotide sequence ID" value="XM_626791.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUM3"/>
    <dbReference type="GeneID" id="3373782"/>
    <dbReference type="KEGG" id="cpv:cgd3_2240"/>
    <dbReference type="InParanoid" id="Q5CUM3"/>
    <dbReference type="OMA" id="KVQRHPG"/>
    <dbReference type="OrthoDB" id="15001at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043248">
        <property type="term" value="P:proteasome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008012">
        <property type="entry name" value="Ump1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828:SF3">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12828">
        <property type="entry name" value="PROTEASOME MATURATION PROTEIN UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05348">
        <property type="entry name" value="UMP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00043974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="90" mass="10007" checksum="64F4EF6906BEA435" modified="2005-04-12" version="1" fragment="single">GFIRTLENELNMLSAIQGYHSAAKSRMEQDLVSKVQRHPGIPSSHLSLDLLMNMDDKIEISDILGTEKPINPLGKKTISDTLESIFNINS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUT8</accession>
    <name>Q5CUT8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA-editing substrate-binding complex 6 protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89138.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626726.1">
        <property type="nucleotide sequence ID" value="XM_626726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUT8"/>
    <dbReference type="STRING" id="353152.Q5CUT8"/>
    <dbReference type="GeneID" id="3374028"/>
    <dbReference type="KEGG" id="cpv:cgd3_1520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1520"/>
    <dbReference type="InParanoid" id="Q5CUT8"/>
    <dbReference type="OMA" id="CCTIDEW"/>
    <dbReference type="OrthoDB" id="442505at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005759">
        <property type="term" value="C:mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035770">
        <property type="term" value="C:ribonucleoprotein granule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000963">
        <property type="term" value="P:mitochondrial RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044528">
        <property type="term" value="P:regulation of mitochondrial mRNA stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050870">
        <property type="entry name" value="FAST_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058917">
        <property type="entry name" value="RESC6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228">
        <property type="entry name" value="FAST LEU-RICH DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21228:SF40">
        <property type="entry name" value="LD45607P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26188">
        <property type="entry name" value="RESC6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="569"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="RNA-editing substrate-binding complex 6 protein" evidence="2">
        <location>
            <begin position="136"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89138.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="589" mass="67578" checksum="A8D7DC5894981F48" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUX8</accession>
    <name>Q5CUX8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_1080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626686.1">
        <property type="nucleotide sequence ID" value="XM_626686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUX8"/>
    <dbReference type="GeneID" id="3374171"/>
    <dbReference type="KEGG" id="cpv:cgd3_1080"/>
    <dbReference type="InParanoid" id="Q5CUX8"/>
    <dbReference type="OrthoDB" id="343312at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="114" mass="13488" checksum="6809F73D1FE4ED2D" modified="2005-04-12" version="1">MEWKLYIWIPPLDKGKIAYSVCCKNEKYPERLIYSYLRELNKSTLRIERINENMPNKINELNGIKNFKEDIKSLVSQYDDFENFDKIVQLEDSAKEIAGTIQNNIQILLNNKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV26</accession>
    <name>Q5CV26_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SCAR/WAVE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626638.1">
        <property type="nucleotide sequence ID" value="XM_626638.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV26"/>
    <dbReference type="GeneID" id="3373797"/>
    <dbReference type="KEGG" id="cpv:cgd3_530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_530"/>
    <dbReference type="InParanoid" id="Q5CV26"/>
    <dbReference type="OMA" id="FNILECI"/>
    <dbReference type="OrthoDB" id="342312at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071933">
        <property type="term" value="F:Arp2/3 complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034237">
        <property type="term" value="F:protein kinase A regulatory subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030036">
        <property type="term" value="P:actin cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000601">
        <property type="term" value="P:positive regulation of Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028288">
        <property type="entry name" value="SCAR/WAVE_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902">
        <property type="entry name" value="WASP-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12902:SF1">
        <property type="entry name" value="WISKOTT-ALDRICH SYNDROME PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="69"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1795"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1833"/>
            <end position="1895"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2131"/>
            <end position="2285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="99"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="236"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="286"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="323"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="345"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1800"/>
            <end position="1821"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="1833"/>
            <end position="1848"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1866"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2157"/>
            <end position="2169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2170"/>
            <end position="2184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2189"/>
            <end position="2210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2218"/>
            <end position="2237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2238"/>
            <end position="2249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2250"/>
            <end position="2264"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2265"/>
            <end position="2285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2285" mass="256027" checksum="6877487642979362" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV55</accession>
    <name>Q5CV55_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_5360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627414.1">
        <property type="nucleotide sequence ID" value="XM_627414.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV55"/>
    <dbReference type="GeneID" id="3374216"/>
    <dbReference type="KEGG" id="cpv:cgd8_5360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5360"/>
    <dbReference type="InParanoid" id="Q5CV55"/>
    <dbReference type="OMA" id="MDVEYQH"/>
    <dbReference type="OrthoDB" id="10590559at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="252"/>
            <end position="261"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="261" mass="28132" checksum="9AC0A466550FADB2" modified="2005-04-12" version="1">MNINLKPLIFISFLVLYISYFYSFEESNEFKDALVQYSHLQLRGRKCPSCFSGLGARIRRFFGRGERGIRRRQEATSGYQSHGNRMTLRPLEGSGDGTAGNAEPAGMGGSGLTIENPYADDRNQNNENQNNDENQDNDENQNNDGNQDNDENQNNDGNQNNDGNQDNEQSNGSEAPTPMPPTSGSGGEKPVPKPRTRALGGGRPVPKPRTRALGGGRPVPKPRTKSSGSGNNGGSTPISEQEQVGSDGGEGGPDDDEAVFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV93</accession>
    <name>Q5CV93_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Trehalose-6-phosphate synthase of likely plant origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_4940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the glycosyltransferase 20 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627376.1">
        <property type="nucleotide sequence ID" value="XM_627376.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV93"/>
    <dbReference type="GeneID" id="3374378"/>
    <dbReference type="KEGG" id="cpv:cgd8_4940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4940"/>
    <dbReference type="InParanoid" id="Q5CV93"/>
    <dbReference type="OMA" id="CKDHYRK"/>
    <dbReference type="OrthoDB" id="755951at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004805">
        <property type="term" value="F:trehalose-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005992">
        <property type="term" value="P:trehalose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001830">
        <property type="entry name" value="Glyco_trans_20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003337">
        <property type="entry name" value="Trehalose_PPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788:SF94">
        <property type="entry name" value="ALPHA,ALPHA-TREHALOSE-PHOSPHATE SYNTHASE [UDP-FORMING] 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10788">
        <property type="entry name" value="TREHALOSE-6-PHOSPHATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00982">
        <property type="entry name" value="Glyco_transf_20"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02358">
        <property type="entry name" value="Trehalose_PPase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="494"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="782"/>
            <end position="818"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1083"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1306"/>
            <end position="1335"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1183"/>
            <end position="1215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="499"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="801"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1091"/>
            <end position="1136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1417" mass="159243" checksum="86391A04AEC714DC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVA9</accession>
    <name>Q5CVA9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Arginine n-methyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_4760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627360.1">
        <property type="nucleotide sequence ID" value="XM_627360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVA9"/>
    <dbReference type="FunCoup" id="Q5CVA9">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVA9"/>
    <dbReference type="GeneID" id="3374348"/>
    <dbReference type="KEGG" id="cpv:cgd8_4760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4760"/>
    <dbReference type="InParanoid" id="Q5CVA9"/>
    <dbReference type="OMA" id="CTHTKVK"/>
    <dbReference type="OrthoDB" id="7848332at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042054">
        <property type="term" value="F:histone methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016274">
        <property type="term" value="F:protein-arginine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.70.160.11:FF:000001">
        <property type="entry name" value="Blast:Protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000116">
        <property type="entry name" value="probable protein arginine N-methyltransferase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025799">
        <property type="entry name" value="Arg_MeTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055135">
        <property type="entry name" value="PRMT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11006:SF53">
        <property type="entry name" value="PROTEIN ARGININE N-METHYLTRANSFERASE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06325">
        <property type="entry name" value="PrmA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22528">
        <property type="entry name" value="PRMT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51678">
        <property type="entry name" value="SAM_MT_PRMT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 6" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 6 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein arginine N-methyltransferase" evidence="7">
        <location>
            <begin position="171"/>
            <end position="333"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="348" mass="40447" checksum="F2EC9BFCFC9882F3" modified="2005-04-12" version="1">MIKPTEEELKEFKNSWNPLVQEDISSADYYFNSYAHFGIHEEMLKDSVRTGSYQKAIMSNKHLFQDKIVLDVGSGTGILCMFAAMAGAKHVYGIECSEIVHVARNIIKDNNLSDKITFIQSKAEEAVLPVEKVDIIISEWMGYLLLYESMLDTVLFCRDKWLKEDGLIFPDRAQMYIAGIEDAEYKQEKLGYWNNVYGFNYQYVKPCIMEEPIIDTVGENAVNTSSYCILDIDLYKCKKEDLEFVSPFYLKAARKDFVHAFIVWFDIIFGCGHKPVTFTTSPFGKYTHWKQSVFYFEEDLVCDTNDMISGIFALKKNTKNVRDLDIKIKFNFTKNNSSIERINYYRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVF4</accession>
    <name>Q5CVF4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_4260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89568.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627315.1">
        <property type="nucleotide sequence ID" value="XM_627315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVF4"/>
    <dbReference type="FunCoup" id="Q5CVF4">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVF4"/>
    <dbReference type="GeneID" id="3374549"/>
    <dbReference type="KEGG" id="cpv:cgd8_4260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4260"/>
    <dbReference type="InParanoid" id="Q5CVF4"/>
    <dbReference type="OMA" id="MKIYCAR"/>
    <dbReference type="OrthoDB" id="442921at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd16116">
        <property type="entry name" value="Ubl_Smt3_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022617">
        <property type="entry name" value="Rad60/SUMO-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10562">
        <property type="entry name" value="SMALL UBIQUITIN-RELATED MODIFIER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11976">
        <property type="entry name" value="Rad60-SLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="43"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89568.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="122" mass="13384" checksum="5DFB7020EB66D9A4" modified="2005-04-12" version="1">MDPGFTDNSSMGAGEGSNDGHQIEQKPVIDQGTGGASDDSQYVTVKVRSPDGEQVLYRIKKKTRLQKLMNSFCQRTGQNEQSIRFLFEGERLRPEMTAEDAGLQEGDLIDAMISQVGGGIRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVF5</accession>
    <name>Q5CVF5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Possible spliceosome factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_4240</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627314.1">
        <property type="nucleotide sequence ID" value="XM_627314.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CVF5">
        <property type="interactions" value="605"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVF5"/>
    <dbReference type="GeneID" id="3374548"/>
    <dbReference type="KEGG" id="cpv:cgd8_4240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4240"/>
    <dbReference type="InParanoid" id="Q5CVF5"/>
    <dbReference type="OMA" id="PRATGHW"/>
    <dbReference type="OrthoDB" id="436637at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:001143">
        <property type="entry name" value="Pre-mRNA-splicing factor rse-1, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018846">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_1st"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058543">
        <property type="entry name" value="Beta-prop_RSE1/DDB1/CPSF1_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050358">
        <property type="entry name" value="RSE1/DDB1/CFT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004871">
        <property type="entry name" value="RSE1/DDB1/CPSF1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10644">
        <property type="entry name" value="DNA REPAIR/RNA PROCESSING CPSF FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10433">
        <property type="entry name" value="Beta-prop_RSE1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23726">
        <property type="entry name" value="Beta-prop_RSE1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03178">
        <property type="entry name" value="CPSF_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69322">
        <property type="entry name" value="Tricorn protease domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="RSE1/DDB1/CPSF1 first beta-propeller" evidence="7">
        <location>
            <begin position="14"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 second beta-propeller" evidence="8">
        <location>
            <begin position="440"/>
            <end position="781"/>
        </location>
    </feature>
    <feature type="domain" description="RSE1/DDB1/CPSF1 C-terminal" evidence="6">
        <location>
            <begin position="945"/>
            <end position="1284"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03178"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF10433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF23726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1317" mass="146809" checksum="239174E13C1DD6EF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVG8</accession>
    <name>Q5CVG8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_4100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627301.1">
        <property type="nucleotide sequence ID" value="XM_627301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVG8"/>
    <dbReference type="FunCoup" id="Q5CVG8">
        <property type="interactions" value="577"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVG8"/>
    <dbReference type="GeneID" id="3374187"/>
    <dbReference type="KEGG" id="cpv:cgd8_4100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4100"/>
    <dbReference type="InParanoid" id="Q5CVG8"/>
    <dbReference type="OMA" id="MKVYPLY"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.1080:FF:000001">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000007">
        <property type="entry name" value="Pre-mRNA-splicing factor ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000615">
        <property type="entry name" value="pre-mRNA-splicing factor ATP-dependent RNA helicase DEAH7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011709">
        <property type="entry name" value="DEAD-box_helicase_OB_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048333">
        <property type="entry name" value="HA2_WH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF109">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21010">
        <property type="entry name" value="HA2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07717">
        <property type="entry name" value="OB_NTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04408">
        <property type="entry name" value="WHD_HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="56"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="247"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="714" mass="81590" checksum="6B55F044116C0A1F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVK1</accession>
    <name>Q5CVK1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted membrane associated protein, signal peptide, transmembrane domain near C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3760</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627268.1">
        <property type="nucleotide sequence ID" value="XM_627268.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3374282"/>
    <dbReference type="KEGG" id="cpv:cgd8_3760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3760"/>
    <dbReference type="InParanoid" id="Q5CVK1"/>
    <dbReference type="OMA" id="CAHATIH"/>
    <dbReference type="OrthoDB" id="445004at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254556" evidence="2">
        <location>
            <begin position="25"/>
            <end position="2123"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="2013"/>
            <end position="2036"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2123" mass="241884" checksum="050EF806AAA1F3F7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVM8</accession>
    <name>Q5CVM8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S ribosomal protein L34</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_3480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL34 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89713.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627241.1">
        <property type="nucleotide sequence ID" value="XM_627241.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVM8"/>
    <dbReference type="FunCoup" id="Q5CVM8">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVM8"/>
    <dbReference type="GeneID" id="3374620"/>
    <dbReference type="KEGG" id="cpv:cgd8_3480"/>
    <dbReference type="InParanoid" id="Q5CVM8"/>
    <dbReference type="OMA" id="RCHKCVR"/>
    <dbReference type="OrthoDB" id="277449at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.340.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.370.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008195">
        <property type="entry name" value="Ribosomal_eL34"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038562">
        <property type="entry name" value="Ribosomal_eL34_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018065">
        <property type="entry name" value="Ribosomal_eL34_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10759">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L34"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01199">
        <property type="entry name" value="Ribosomal_L34e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01250">
        <property type="entry name" value="RIBOSOMALL34"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01145">
        <property type="entry name" value="RIBOSOMAL_L34E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="109"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="109"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="126"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009875"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89713.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="138" mass="15749" checksum="0CBA507373ACE264" modified="2005-04-12" version="1" fragment="single">FQKMSPRVTYRRKCRYNTPSNRVRVVKTPGGRNLIQNIGKVYSRPKCGDCKKPLAGIPACAPYEMKHLKKRERTVARAYGGTKCPTCVRQRILRAFLLEEQKVVKSVIAEKEQQKKSEEKPKVNKKSAGSKQASSKRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVN6</accession>
    <name>Q5CVN6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Rrp12p like nucleolar protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_3380</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RRP12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627233.1">
        <property type="nucleotide sequence ID" value="XM_627233.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVN6"/>
    <dbReference type="GeneID" id="3374299"/>
    <dbReference type="KEGG" id="cpv:cgd8_3380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3380"/>
    <dbReference type="InParanoid" id="Q5CVN6"/>
    <dbReference type="OMA" id="WALDACK"/>
    <dbReference type="OrthoDB" id="2192888at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012978">
        <property type="entry name" value="HEAT_RRP12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052087">
        <property type="entry name" value="RRP12"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48287:SF1">
        <property type="entry name" value="ARM REPEAT SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08161">
        <property type="entry name" value="RRP12_HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RRP12 HEAT" evidence="3">
        <location>
            <begin position="390"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1268"/>
            <end position="1296"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1339" mass="155343" checksum="613E9D9046DAFBC4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW73</accession>
    <name>Q5CW73_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627046.1">
        <property type="nucleotide sequence ID" value="XM_627046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW73"/>
    <dbReference type="GeneID" id="3374516"/>
    <dbReference type="KEGG" id="cpv:cgd8_1390"/>
    <dbReference type="InParanoid" id="Q5CW73"/>
    <dbReference type="OMA" id="NEREHRQ"/>
    <dbReference type="OrthoDB" id="339406at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="303" mass="35008" checksum="5C3AFB2806A0AB6B" modified="2005-04-12" version="1">MINTAQLRYENSNDQVSKKESIALNWNSWYFFPEQIIDLSLVKIQDFLILDKNLMNSNDNNIYEKLKEISLKRWNMPNTGSYSITITDDVVPGHYLILILNGTKNFVNINNLVENGLVSKPIIINQRPTKEQRIILNYPKSSRPYGFSDVIYVNYRIFNEKNEIEDAKNKASIHIYSVDPDDSSLIEPRQYFETISNEISILGLGLEKCPTYYKITAKMLEHPFHQDSSQYIWVLPKNTSPLSLSNADLLSIRQLCIRQNNKFGMFPTIIEFGILLIITVINIIGLITLGVIINKLNKKKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW78</accession>
    <name>Q5CW78_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mediator of RNA polymerase II transcription subunit 14</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="1">Mediator complex subunit 14</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_1340</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the Mediator complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the Mediator complex subunit 14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89348.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627041.1">
        <property type="nucleotide sequence ID" value="XM_627041.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW78"/>
    <dbReference type="GeneID" id="3374510"/>
    <dbReference type="KEGG" id="cpv:cgd8_1340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1340"/>
    <dbReference type="InParanoid" id="Q5CW78"/>
    <dbReference type="OMA" id="INDNDRE"/>
    <dbReference type="OrthoDB" id="205099at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031461">
        <property type="term" value="C:cullin-RING ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016592">
        <property type="term" value="C:mediator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990756">
        <property type="term" value="F:ubiquitin-like ligase-substrate adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032436">
        <property type="term" value="P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019138">
        <property type="entry name" value="De-etiolated_protein_1_Det1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055122">
        <property type="entry name" value="Med14_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374:SF3">
        <property type="entry name" value="DET1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13374">
        <property type="entry name" value="DET1 HOMOLOG DE-ETIOLATED-1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08638">
        <property type="entry name" value="Med14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0010">Activator</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Mediator complex subunit MED14 N-terminal" evidence="3">
        <location>
            <begin position="18"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2069"/>
            <end position="2227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2251"/>
            <end position="2395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2450"/>
            <end position="2470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2540"/>
            <end position="2595"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2655"/>
            <end position="2674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2686"/>
            <end position="2709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2772"/>
            <end position="2799"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2072"/>
            <end position="2144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2155"/>
            <end position="2202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="2203"/>
            <end position="2227"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2251"/>
            <end position="2331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="2339"/>
            <end position="2395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89348.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2806" mass="324952" checksum="647EF8E42777A64C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWA1</accession>
    <name>Q5CWA1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ER lumen protein-retaining receptor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_1110</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the ERD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89671.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627018.1">
        <property type="nucleotide sequence ID" value="XM_627018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWA1"/>
    <dbReference type="FunCoup" id="Q5CWA1">
        <property type="interactions" value="110"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWA1"/>
    <dbReference type="GeneID" id="3374636"/>
    <dbReference type="KEGG" id="cpv:cgd8_1110"/>
    <dbReference type="InParanoid" id="Q5CWA1"/>
    <dbReference type="OMA" id="WKSRSCE"/>
    <dbReference type="OrthoDB" id="7694678at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046923">
        <property type="term" value="F:ER retention sequence binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006621">
        <property type="term" value="P:protein retention in ER lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000133">
        <property type="entry name" value="ER_ret_rcpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10585">
        <property type="entry name" value="ER LUMEN PROTEIN RETAINING RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00810">
        <property type="entry name" value="ER_lumen_recept"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00660">
        <property type="entry name" value="ERLUMENR"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00952">
        <property type="entry name" value="ER_LUMEN_RECEPTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10 11 12" id="KW-0675">Receptor</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="62"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="154"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="182"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010120"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000634"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89671.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="220" mass="26213" checksum="82B96CA70A319A94" modified="2005-04-12" version="1" fragment="single">KMNGFRLCGDMLHLLSIFLLLKKLRKSKSCLGISCKMQEIYLIVFCSRYIDLLWSFVSVYNTLMKVVFIASTSYCIYLMRYQIPISRTYDSNADSFPYHKYLLLPALLLGFITSEKWIVSEILWSFSIWLESVAILPQLVLLQQLREVENLTSNYVVTMGLYRLFYIFNWIYRFYAQHYVNWVGWIGGLIQTAIYVDFFYYYAMSKWYGQKLILPYSIEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWI7</accession>
    <name>Q5CWI7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90070.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627817.1">
        <property type="nucleotide sequence ID" value="XM_627817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWI7"/>
    <dbReference type="GeneID" id="3375815"/>
    <dbReference type="KEGG" id="cpv:cgd6_4920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4920"/>
    <dbReference type="InParanoid" id="Q5CWI7"/>
    <dbReference type="OMA" id="ICNEIRM"/>
    <dbReference type="OrthoDB" id="340773at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90070.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="573" mass="66569" checksum="0487D26026A6F680" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWP9</accession>
    <name>Q5CWP9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_4230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627755.1">
        <property type="nucleotide sequence ID" value="XM_627755.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWP9"/>
    <dbReference type="SMR" id="Q5CWP9"/>
    <dbReference type="GeneID" id="3375769"/>
    <dbReference type="KEGG" id="cpv:cgd6_4230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4230"/>
    <dbReference type="InParanoid" id="Q5CWP9"/>
    <dbReference type="OrthoDB" id="343614at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253925" evidence="2">
        <location>
            <begin position="22"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="172"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="89"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="173"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="243"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="489" mass="55274" checksum="1F3C4703E385F61C" modified="2007-04-03" version="1">MTVLYSYISLLFLFLLQFSFGSSLKSNPLGNENNYQAYSDRNHYSSNKKVGPKGIVSPGGLGSNRANYSYNSQSVNNGGALSHSRTVHSRSSLSPGNQILLTQPSSSYSTSSLNPSVQSTFYKYYLESIGKSPTAQSSQYNIYGQRFSNYSPLNPHRTPFYDYYLSSVGQSSYRKDSDRSYDKNKQKPLTNLGYNDSKKQWREQKSIYGQTLPHKSPTTDLQIINSKSKQSLRSQQGSTTKTETSHSEKPHTSELKEVIERLSNETSTVRGPVIDKQPLTLSVILIEEDYQSFRRVSRCCILIQDFVDIALMIISNIVKTWTGNSELLEEMLIQATTAFSILHSSLSSCKTKLLSLDPSNKFALSITHGPYIDEETVKHSEKSLDIEDEKQYKTVLRSIRKISFKVNENSDLITKIFKLKQMDQQCKDFGISSCRRALINILNIYSKVLKEELDKAQLAADIYTANEIFDESAQSDFDKYVLKISESSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWY4</accession>
    <name>Q5CWY4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_3250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627670.1">
        <property type="nucleotide sequence ID" value="XM_627670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWY4"/>
    <dbReference type="GeneID" id="3375696"/>
    <dbReference type="KEGG" id="cpv:cgd6_3250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3250"/>
    <dbReference type="InParanoid" id="Q5CWY4"/>
    <dbReference type="OrthoDB" id="344057at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="30"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="73"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="225" mass="26068" checksum="826E3E5F30385579" modified="2007-04-03" version="1">MSDVSENTLKIIKAANRSLQLHQDRLGKTKIAENKENSQFKSQNKIELGDEKSSRLKTKRVNSKKEIEIVTKKQHDEESIEKTQEKVRELEDQISKILEYSSVLEETLKKNIDQTNKINKNHCCCNQQTHNKKLDKLMIADIVKDVVYSLNRKKIQPQVKPYIIHTKTQSKINSNLSIYTSTVEYLSNFILELCIDDILTSLDTSIHNFSVKLVKGKYFETETIP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX51</accession>
    <name>Q5CX51_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CCR4-NOT transcription complex, subunit 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_2480</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627603.1">
        <property type="nucleotide sequence ID" value="XM_627603.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX51"/>
    <dbReference type="STRING" id="353152.Q5CX51"/>
    <dbReference type="GeneID" id="3375884"/>
    <dbReference type="KEGG" id="cpv:cgd6_2480"/>
    <dbReference type="InParanoid" id="Q5CX51"/>
    <dbReference type="OMA" id="RIHSKWI"/>
    <dbReference type="OrthoDB" id="25391at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="124"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="17"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="276"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="281"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="320"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="342" mass="38859" checksum="3B473B2F278FBB21" modified="2005-04-12" version="1" fragment="single">SVCKGFILPNSKSLMDAKNQVQKSSSSSCDQEDTSPQNNTINSQNQCDQQTSTQNNVDKDLSLEDILYETNQQAISYNRTNYGLLGILNVIRMTDSDLNILALGTDLTTLGLNLNSSECLYLNFDSPWSSSKPAQPESETNEIIQAFANTPNNVSQIIGLKSTYVQKFALETLFYIFYNMPQDLLQGFAAVELCNRGWLYYPDSLQWYSKVQNEEKQTAEWQVFDTDKWCKVPISDPPSSNLLSIDEIRPSVEEGVRIHSKWIQEQNQIYQIVQQQMQQQSNSRNKGSEPQINSNMNNISDFSSAYNQRSIQQTFSQAGNNQTINSNNYSNFRSSNRHNSSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX57</accession>
    <name>Q5CX57_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">SRR1-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_2420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89889.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627597.1">
        <property type="nucleotide sequence ID" value="XM_627597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX57"/>
    <dbReference type="GeneID" id="3376129"/>
    <dbReference type="KEGG" id="cpv:cgd6_2420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2420"/>
    <dbReference type="InParanoid" id="Q5CX57"/>
    <dbReference type="OMA" id="YICDPAF"/>
    <dbReference type="OrthoDB" id="337854at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012942">
        <property type="entry name" value="SRR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040044">
        <property type="entry name" value="SRR1L"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28626:SF3">
        <property type="entry name" value="SRR1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07985">
        <property type="entry name" value="SRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SRR1-like" evidence="2">
        <location>
            <begin position="76"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009856"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF07985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89889.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="269" mass="31125" checksum="717B6885A875D934" modified="2007-04-03" version="1">MKSSIDKNINTNVNIRSLKAKVLECKRKLLKSEFWGTIVEHLETEIFENWIKGRKCSSSRCILRGRCICYNNVFFVIGLGSLESTINSNLSSFFQLAAVIALNERINLEGIYFCDPEFTQADRELIFELFMEFKTHIEVFTSHDLSIPLNTVNHQLKNKLYGRDSQINILFFMPHCDRCVFGMIINYFNSGEGKTLYSDSARMIVWGNNLETFQIDSNENFNKRCEYCKVLSTSLSKMNFSTINFPVNDYKTIFCSSFSDLSIYHLPVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX63</accession>
    <name>Q5CX63_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_2340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SLC43A transporter (TC 2.A.1.44) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627591.1">
        <property type="nucleotide sequence ID" value="XM_627591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX63"/>
    <dbReference type="GeneID" id="3376182"/>
    <dbReference type="KEGG" id="cpv:cgd6_2340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2340"/>
    <dbReference type="InParanoid" id="Q5CX63"/>
    <dbReference type="OMA" id="QIMNITT"/>
    <dbReference type="OrthoDB" id="330047at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052599">
        <property type="entry name" value="SLC43A_AATransporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20772:SF2">
        <property type="entry name" value="PROTEIN FMP42"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="454"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="480"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="505"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="541"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="572"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006595"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="599" mass="67534" checksum="A13EC10C590B75A5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX68</accession>
    <name>Q5CX68_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sphingomyelinase C</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_2290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the neutral sphingomyelinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89880.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627586.1">
        <property type="nucleotide sequence ID" value="XM_627586.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX68"/>
    <dbReference type="STRING" id="353152.Q5CX68"/>
    <dbReference type="GeneID" id="3376178"/>
    <dbReference type="KEGG" id="cpv:cgd6_2290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2290"/>
    <dbReference type="InParanoid" id="Q5CX68"/>
    <dbReference type="OMA" id="CDYIFLP"/>
    <dbReference type="OrthoDB" id="387657at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004767">
        <property type="term" value="F:sphingomyelin phosphodiesterase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038772">
        <property type="entry name" value="Sph/SMPD2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320:SF23">
        <property type="entry name" value="SPHINGOMYELINASE C 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16320">
        <property type="entry name" value="SPHINGOMYELINASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Endonuclease/exonuclease/phosphatase" evidence="2">
        <location>
            <begin position="16"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF03372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89880.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="509" mass="57773" checksum="5F532E8FADC448B1" modified="2007-04-03" version="1">MWADEDELPDRISFLTFNAGLLEYRICGVKLYQNPPYTSHRLLQIPSALRGINADIIALQEVFDEKHSDYIIESLQPVYPYFARETKQSQNQKSMRWQPISVIHNQLALHNGLLVLSKYPILNARFTCFSDVTLIEEWFVSKGMLEVTIQLPGMDKSPLTLFNIHMASGAVNPESETIETLRNKEIEQLLGACDHAIRRGEVPVIIGDLNAAPNCCGSNYNYFIDRGWRDCFECFKHENRYSTSASSNISSQINLKSRQNDFDYKGKQTYIDMDDLYDDLSCYSKENFAHREEQIEEEEHATPSSNDSFSTRIEIDTTPMINMSIGSSSINKGNDDVAVVNKLVSSFAVAKAAVEVAKRGFSSCSPESTSIEVVSTTKSSNCSNNINEFQENYPIKQYFPGNKDYCSSKLFSSDFTWDPNNPLNVIGPHSNCHGQRCDHIFLPPTHLSKKLAQYEPYKSSVILREPRVLVDGWCFGCVGSTVLVTLSDHYGVYVELKRKLDNNYRNSQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX78</accession>
    <name>Q5CX78_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 5B</fullName>
            <ecNumber evidence="3">3.6.5.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">Translation initiation factor IF-2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd6_2180</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627576.1">
        <property type="nucleotide sequence ID" value="XM_627576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX78"/>
    <dbReference type="FunCoup" id="Q5CX78">
        <property type="interactions" value="313"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX78"/>
    <dbReference type="GeneID" id="3375881"/>
    <dbReference type="KEGG" id="cpv:cgd6_2180"/>
    <dbReference type="InParanoid" id="Q5CX78"/>
    <dbReference type="OMA" id="FRQSKPA"/>
    <dbReference type="OrthoDB" id="4928at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03703">
        <property type="entry name" value="aeIF5B_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16266">
        <property type="entry name" value="IF2_aeIF5B_IV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01887">
        <property type="entry name" value="IF2_eIF5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000013">
        <property type="entry name" value="eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000026">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10050:FF:000002">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000112">
        <property type="entry name" value="Eukaryotic translation initiation factor 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10050">
        <property type="entry name" value="Translation initiation factor IF- 2, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029459">
        <property type="entry name" value="EFTU-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015760">
        <property type="entry name" value="TIF_IF2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023115">
        <property type="entry name" value="TIF_IF2_dom3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036925">
        <property type="entry name" value="TIF_IF2_dom3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003078">
        <property type="entry name" value="PRK04004.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 5B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43381">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR IF-2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14578">
        <property type="entry name" value="GTP_EFTU_D4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11987">
        <property type="entry name" value="IF-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52156">
        <property type="entry name" value="Initiation factor IF2/eIF5b, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6 16" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="14">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254505" description="Eukaryotic translation initiation factor 5B" evidence="14">
        <location>
            <begin position="21"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="domain" description="Tr-type G" evidence="15">
        <location>
            <begin position="301"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="61"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="13">
        <location>
            <begin position="63"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="87"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="101"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK90136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="896" mass="100883" checksum="C0E46074461EEF19" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX85</accession>
    <name>Q5CX85_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CpCOWP1, oocyst wall protein with type I and type II cysteine-rich repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_2090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627569.1">
        <property type="nucleotide sequence ID" value="XM_627569.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX85"/>
    <dbReference type="GeneID" id="3375880"/>
    <dbReference type="KEGG" id="cpv:cgd6_2090"/>
    <dbReference type="InParanoid" id="Q5CX85"/>
    <dbReference type="OMA" id="THECHEN"/>
    <dbReference type="OrthoDB" id="7250310at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006150">
        <property type="entry name" value="Cys_repeat_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157:SF4">
        <property type="entry name" value="EB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157">
        <property type="entry name" value="PRION-LIKE-(Q/N-RICH) DOMAIN-BEARING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00289">
        <property type="entry name" value="WR1"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254594" evidence="2">
        <location>
            <begin position="22"/>
            <end position="1629"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="737"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1458"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="745"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1458"/>
            <end position="1467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1468"/>
            <end position="1482"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1629" mass="176497" checksum="2742CF366EF51258" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXL2</accession>
    <name>Q5CXL2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Vesicle transport protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_630</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Membrane</location>
            <topology evidence="1 8">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7 8">Belongs to the SFT2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627442.1">
        <property type="nucleotide sequence ID" value="XM_627442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXL2"/>
    <dbReference type="FunCoup" id="Q5CXL2">
        <property type="interactions" value="36"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXL2"/>
    <dbReference type="GeneID" id="3375862"/>
    <dbReference type="KEGG" id="cpv:cgd6_630"/>
    <dbReference type="InParanoid" id="Q5CXL2"/>
    <dbReference type="OMA" id="ISCCDTE"/>
    <dbReference type="OrthoDB" id="660759at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007305">
        <property type="entry name" value="Vesicle_transpt_Got1/SFT2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011691">
        <property type="entry name" value="Vesicle_transpt_SFT2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137:SF36">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN SFT2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23137">
        <property type="entry name" value="VESICLE TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04178">
        <property type="entry name" value="Got1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2 8" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="42"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="73"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="131"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00025800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU363111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="186" mass="20820" checksum="0E93BC82316929BB" modified="2005-04-12" version="1" fragment="single">NCRKNQLKMMLAKITTESAKNVIYKAQQKVQDTTETLNPQKILTFLLCMGTSILFLSLSFMFLPIIVVSPHKFAILFTFGSFFFMASFAVLKGLGGFFKYMVEKERLPFSFVYISSLSLTLYATLFLKSYLLTLLFSLVQIIALVSFLITNFPGGYSALNYVSNNLFSGLASKLSFSSGKNTPLPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXP6</accession>
    <name>Q5CXP6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_5410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90489.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628684.1">
        <property type="nucleotide sequence ID" value="XM_628682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXP6"/>
    <dbReference type="GeneID" id="3372146"/>
    <dbReference type="KEGG" id="cpv:cgd7_5410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5410"/>
    <dbReference type="InParanoid" id="Q5CXP6"/>
    <dbReference type="OrthoDB" id="342119at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040324">
        <property type="entry name" value="WDR44/Dgr2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221">
        <property type="entry name" value="WD REPEAT DOMAIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14221:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 44"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="549"/>
            <end position="592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90489.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="890" mass="99894" checksum="DA34D973D1115C56" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXX8</accession>
    <name>Q5CXX8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ABC ATpase (2 ABC domains) with 10 transmembrane domains, adjacent duplicated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_4520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628602.1">
        <property type="nucleotide sequence ID" value="XM_628600.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXX8"/>
    <dbReference type="GeneID" id="3372181"/>
    <dbReference type="KEGG" id="cpv:cgd7_4520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4520"/>
    <dbReference type="InParanoid" id="Q5CXX8"/>
    <dbReference type="OMA" id="QVTDAWT"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
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        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
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    </dbReference>
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        <property type="match status" value="2"/>
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        <property type="match status" value="2"/>
    </dbReference>
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        <property type="match status" value="2"/>
    </dbReference>
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    <feature type="transmembrane region" description="Helical" evidence="10">
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            <begin position="135"/>
            <end position="156"/>
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            <begin position="202"/>
            <end position="219"/>
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            <begin position="314"/>
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            <begin position="447"/>
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            <begin position="1055"/>
            <end position="1076"/>
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            <end position="1102"/>
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            <begin position="136"/>
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            <begin position="526"/>
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            <begin position="838"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
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        <source>
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            <dbReference type="ARBA" id="ARBA00022989"/>
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        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
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        <source>
            <dbReference type="PROSITE" id="PS50929"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAK90427.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1393" mass="156512" checksum="12683D6C894D12C8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY20</accession>
    <name>Q5CY20_CRYPI</name>
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        <submittedName>
            <fullName evidence="3">Hypothetical low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
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            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
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            <taxon>Apicomplexa</taxon>
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            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        </location>
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        <location>
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        <source>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAK90390.1"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="586" mass="63594" checksum="EDBC56D14D4EE5BA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY99</accession>
    <name>Q5CY99_CRYPI</name>
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        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
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            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_628479.1"/>
    </dbReference>
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    <dbReference type="KEGG" id="cpv:cgd7_3160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3160"/>
    <dbReference type="InParanoid" id="Q5CY99"/>
    <dbReference type="OMA" id="IMCAFIL"/>
    <dbReference type="OrthoDB" id="340726at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="353"/>
            <end position="375"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="384" mass="44364" checksum="D7822600D230EE2E" modified="2005-04-12" version="1">MNEEFKNIDSWRGSVAGTTLRINGRKRNENTTSFFRTEIFNLLIVQITMISIMCIFIFIGVSLHVVKLKKIHADEYISHFNLDNDTSNILTENLRSIENSMGQMSFFRVLRNNLDLSLPMKNNKDGNIIFCGGTHRRGTNWSEEVINITKRTIEIALGNRVLIEFKRGLVFAINTVDIESSNIGVNQDHLNQLNNGSMLFKLFLASSGYVSPCYMFGKRLYSYILGKNSGFLGYFMVMIPWFFSILSPQPMLLVHFPRLLIYFLIAMHRVIFLHIIINIAEKKLFSFDFSDHIVLYAMYILIISIEWCAIGYNIKNKFVVSCIRGYCLSLLAIISYSSFFTALYFHFPLETLAGFIIAFFGLFGIFWMLIFLEYIDLTKIGLHK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYB3</accession>
    <name>Q5CYB3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Repressor of RNA polymerase III transcription</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the MAF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628467.1">
        <property type="nucleotide sequence ID" value="XM_628465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYB3"/>
    <dbReference type="STRING" id="353152.Q5CYB3"/>
    <dbReference type="GeneID" id="3372284"/>
    <dbReference type="KEGG" id="cpv:cgd7_3000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3000"/>
    <dbReference type="InParanoid" id="Q5CYB3"/>
    <dbReference type="OMA" id="FYVIENI"/>
    <dbReference type="OrthoDB" id="277029at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000994">
        <property type="term" value="F:RNA polymerase III core binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016480">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1000.50">
        <property type="entry name" value="Repressor of RNA polymerase III transcription Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015257">
        <property type="entry name" value="Maf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038564">
        <property type="entry name" value="Maf1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22504:SF0">
        <property type="entry name" value="REPRESSOR OF RNA POLYMERASE III TRANSCRIPTION MAF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09174">
        <property type="entry name" value="Maf1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037240">
        <property type="entry name" value="RNA_polIII_Trep_MAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0678">Repressor</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRNR" id="PIRNR037240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="218" mass="25274" checksum="C7902F5ADBF0C814" modified="2005-04-12" version="1">MRFLEHSGLNRLSVLLSNLDVGDRILNGRIELFTCSEKVVEECDLSERVDREVCVSPQWISNSPIGPVQRQDVRELLVNLISTMNQCFPDYEFSLIKPDNLFKEKSFSIVYNNINYHLSSIVERIYPSFLLELWENIRDAVEIKYTEIYSYRLMGNDELSPFLDDGSLFSFDYFFYDTKSQKILFFACTTKSKLNIGFTDNGLDSSEESIDDNEIGSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYE1</accession>
    <name>Q5CYE1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628439.1">
        <property type="nucleotide sequence ID" value="XM_628437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYE1"/>
    <dbReference type="GeneID" id="3371934"/>
    <dbReference type="KEGG" id="cpv:cgd7_2690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2690"/>
    <dbReference type="InParanoid" id="Q5CYE1"/>
    <dbReference type="OMA" id="HANILGE"/>
    <dbReference type="OrthoDB" id="443257at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90286.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="279" mass="32330" checksum="2737850BA3A52CEB" modified="2005-04-12" version="1">MKNDLFTDKNRFLSTLGLIGVVIGGVWYITKNNKKEISNRKLDNEEIKNLLVSISNELHPILMEFSNLVSSINIPIDINSIEFSNYSEIIFSNGGFKDKIVRAQKEVIDNLAIDQENFEKLLYSACKVDEEVLMLKLGIDRMYEDSFKGVYPLLPYFGLKADFSKKYPNFTQDHVLRRLRELNNEKEKGLKAVVKELDGLSRHVKEHPISGVIPSEKLSKRLEEINKQSENTVFESIESKRLFSHAIALYSREVEFAEKKRILEREHCDNILNIILNYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYE3</accession>
    <name>Q5CYE3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RAD24/Rf-C activator 1 AAA+ ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_2660</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the rad17/RAD24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90284.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628437.1">
        <property type="nucleotide sequence ID" value="XM_628435.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYE3"/>
    <dbReference type="STRING" id="353152.Q5CYE3"/>
    <dbReference type="GeneID" id="3371932"/>
    <dbReference type="KEGG" id="cpv:cgd7_2660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2660"/>
    <dbReference type="InParanoid" id="Q5CYE3"/>
    <dbReference type="OMA" id="CTILEWI"/>
    <dbReference type="OrthoDB" id="10265971at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00267">
        <property type="entry name" value="ABC_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004582">
        <property type="entry name" value="Checkpoint_prot_Rad17_Rad24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12172:SF0">
        <property type="entry name" value="CELL CYCLE CHECKPOINT PROTEIN RAD17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03215">
        <property type="entry name" value="Rad17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="8">
        <location>
            <begin position="44"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90284.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="701" mass="80571" checksum="AB5AC0E6717EAFF2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYF8</accession>
    <name>Q5CYF8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclin'cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_2490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628422.1">
        <property type="nucleotide sequence ID" value="XM_628420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYF8"/>
    <dbReference type="STRING" id="353152.Q5CYF8"/>
    <dbReference type="GeneID" id="3371918"/>
    <dbReference type="KEGG" id="cpv:cgd7_2490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2490"/>
    <dbReference type="InParanoid" id="Q5CYF8"/>
    <dbReference type="OMA" id="MIPIEAQ"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="386" mass="44562" checksum="049490F5A2E2C01A" modified="2005-04-12" version="1">MLLGAMTRLISNLTQFEGNEKNFSENISGEFEHKNDKIPILKSRLSYSKNSGTILWKYWNKPSEASTRNNSNDELSLLVNQNELSESLTSKSSLFDSGNLDKEKNSVGHSVVEIKRFNESNIKQELRSAISRKSANYGKDRNQLHENNNSMQFNYRSYPLSNSQISSWMNNSWSEYETVEKDIKKCVIMEIDKINNKTEENKKIITPFHSLATPKISIGDYFISRIVKFVSLTPVDFCVMVILIRRAVEKSKGRLSVTSLTAHRLVLATALLTYKLMYDVQYGIKFWAHIGGVPQWEMLMLEYHILKILNWDLSINYHEFKKTYLEILSNKEVRKIMISSKASSSKIDRTEYQNKADYSQVNSDGNKRTKLQLNVSKLSSNRKKCV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYJ0</accession>
    <name>Q5CYJ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Pre-mRNA splicing factor SF3a. 2xSWAP domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_2160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628390.1">
        <property type="nucleotide sequence ID" value="XM_628388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYJ0"/>
    <dbReference type="FunCoup" id="Q5CYJ0">
        <property type="interactions" value="502"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYJ0"/>
    <dbReference type="GeneID" id="3371801"/>
    <dbReference type="KEGG" id="cpv:cgd7_2160"/>
    <dbReference type="InParanoid" id="Q5CYJ0"/>
    <dbReference type="OMA" id="VKYQEQQ"/>
    <dbReference type="OrthoDB" id="447637at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000002">
        <property type="entry name" value="Splicing factor 3A subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.790:FF:000001">
        <property type="entry name" value="Splicing factor 3a, subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.790">
        <property type="entry name" value="Surp module"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045146">
        <property type="entry name" value="SF3A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022030">
        <property type="entry name" value="SF3A1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000061">
        <property type="entry name" value="Surp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035967">
        <property type="entry name" value="SWAP/Surp_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316">
        <property type="entry name" value="SPLICEOSOME ASSOCIATED PROTEIN 114/SWAP SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15316:SF1">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12230">
        <property type="entry name" value="PRP21_like_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01805">
        <property type="entry name" value="Surp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00648">
        <property type="entry name" value="SWAP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109905">
        <property type="entry name" value="Surp module (SWAP domain)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50128">
        <property type="entry name" value="SURP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="19"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="SURP motif" evidence="8">
        <location>
            <begin position="143"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="288"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="462" mass="52986" checksum="601DCB2752BFDFEA" modified="2005-04-12" version="1" fragment="single">ANMSNQVGLIYPPFELRATIDKTASFVAKNGEEFESRILSESGSIKFTFLNKDNPFHLYYKKRIEDFKNGVSIDNSGPTIPRAILDMNSRKEKQIIAEKEVLMLTSFSGGFGFMGGAVMEPEEPRKDQYTISHPIISIKDESVIKITAMYLARNGQSFLSDLTARESNNPQFDFLKPGHALFGYFADLVEAYSLCLIPNKSYLRGMKNESEDLQAIFRRCYKNSLWRKKEVETNSGLLELENRDHVDLEWVAINIVETVDFDDLNLDLPEPVDFSMLSKLVLESSLDMLNENDRNDLLESEIQNEERQINVLVIEKEQINDNVSDELNNTNNDDAFEEEFKNIKIIKNYVRVPKKRGLVTKSEQKKKGKMYRCPITGQLIPDEEISNHMRILLLDPKWKQQKDQLVQRAQQESALTASSNIEENLIAFITKRPDLFGTIEEAVAGTHGFEENGEKNKKQKFQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYX7</accession>
    <name>Q5CYX7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ym1014wp-like, Ymb4 methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_630</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628253.1">
        <property type="nucleotide sequence ID" value="XM_628251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYX7"/>
    <dbReference type="STRING" id="353152.Q5CYX7"/>
    <dbReference type="GeneID" id="3372007"/>
    <dbReference type="KEGG" id="cpv:cgd7_630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_630"/>
    <dbReference type="InParanoid" id="Q5CYX7"/>
    <dbReference type="OMA" id="PCALRKV"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106335">
        <property type="term" value="F:tRNA (5-carboxymethyluridine(34)-5-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002098">
        <property type="term" value="P:tRNA wobble uridine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051422">
        <property type="entry name" value="AlkB_tRNA_MeTrf/Diox"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013216">
        <property type="entry name" value="Methyltransf_11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13069:SF21">
        <property type="entry name" value="ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08241">
        <property type="entry name" value="Methyltransf_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase type 11" evidence="3">
        <location>
            <begin position="85"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF08241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="315" mass="36321" checksum="145EE3B69A07B404" modified="2005-04-12" version="1">MGRSKNKIICNIKPSDKECRPLTCSVPEMLDEKGNILEDKCDELENKYVHEIYETMAEHFSHTRGIPWPKVKDFVSSFEPGSLLLDVGCGNGRFMDCIKDSKVCFMGTDRCKSLLGSAIARNPDLQVFVDDCMRLNVRSGTFDGIICIAVLHHLSTPERRIQAVSELIRCLRRNGTLLIYVWAFEQKKGTVGSRDFSSKDTMVPWHFQKKYAKDEKGEEIQECTLDQFREEKNNYHKEAGAPGNIVKVSPEKYLIALQRYYHLFEEQEIVEICNKGIEKYRENTKCEKNCESDENVTIIETYFDCNNWAIKIAKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ19</accession>
    <name>Q5CZ19_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628211.1">
        <property type="nucleotide sequence ID" value="XM_628209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ19"/>
    <dbReference type="STRING" id="353152.Q5CZ19"/>
    <dbReference type="GeneID" id="3371762"/>
    <dbReference type="KEGG" id="cpv:cgd7_170"/>
    <dbReference type="InParanoid" id="Q5CZ19"/>
    <dbReference type="OMA" id="EHIQIYQ"/>
    <dbReference type="OrthoDB" id="2288928at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="94" mass="10818" checksum="5E33829FE22B3457" modified="2005-04-12" version="1" fragment="single">FILFSFFKKASTNKLFQNNSKIVCGTDEGNLLFFSWDNFGDCTDRMLIPFVDGFENDNSVEHIQIYQDQFAIISTSDGILKVVEFFPNEILGKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ26</accession>
    <name>Q5CZ26_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Integral membrane protein with 6 transmembrane domains and possible ring domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_70</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628204.1">
        <property type="nucleotide sequence ID" value="XM_628202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ26"/>
    <dbReference type="GeneID" id="3372030"/>
    <dbReference type="KEGG" id="cpv:cgd7_70"/>
    <dbReference type="InParanoid" id="Q5CZ26"/>
    <dbReference type="OMA" id="EAVFLAC"/>
    <dbReference type="OrthoDB" id="3045089at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="20"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="51"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="142"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="222"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="328"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="328"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="410" mass="46237" checksum="C13EC1E412D344B0" modified="2005-04-12" version="1">MGVGVLRLTVSWCLLSDVVIRIVHIIGLLSRGISLVMLISYAIIGIPDLEIPLALITGAVIFQVLFASLSSSLRCPWVILRFLFIDIWIGLLLFQIFLRISSESKYYREISKDHFTWETSSQFHGNLTSIAEKFQQIPSWWVVFWPCWFWCGVIFSFSTVFCVLGVADRMLAIFGVFLGCLSTTILITCLDLADFLNDTIYLKENKYAVSYHVYEQNSHIRLWHICIICTQTMIAVMSAVISQGLIQESDEGFSLSSTDDHFITSNIKQFKKMISPYKIGSEVILTKMGTGVFHKIENQSNNTLSQGYSDSKELLSCEAISTHTLSTVNSPTSTNSLSPILSHTPKSKRESFSDSNCTLTPYDDNHEQVCIICCDNNCESVFLPCGHGGLCSNCALREFYRVSYFFNTIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ31</accession>
    <name>Q5CZ31_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_10</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90506.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628199.1">
        <property type="nucleotide sequence ID" value="XM_628197.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ31"/>
    <dbReference type="GeneID" id="3372026"/>
    <dbReference type="KEGG" id="cpv:cgd7_10"/>
    <dbReference type="InParanoid" id="Q5CZ31"/>
    <dbReference type="OrthoDB" id="344124at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005884">
        <property type="term" value="C:actin filament"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030048">
        <property type="term" value="P:actin filament-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053099">
        <property type="entry name" value="WAS/WASL-interacting_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48226">
        <property type="entry name" value="OS06G0326200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48226:SF1">
        <property type="entry name" value="WAS_WASL-INTERACTING PROTEIN FAMILY MEMBER 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="35"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="301"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="560"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="301"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="707"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="760"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="782"/>
            <end position="794"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90506.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="808" mass="89249" checksum="1F8F7E7B4ABE4183" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPQ5</accession>
    <name>A3FPQ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388401.1">
        <property type="nucleotide sequence ID" value="XM_001388364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPQ5"/>
    <dbReference type="STRING" id="353152.A3FPQ5"/>
    <dbReference type="GeneID" id="3371803"/>
    <dbReference type="KEGG" id="cpv:cgd7_4010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4010"/>
    <dbReference type="InParanoid" id="A3FPQ5"/>
    <dbReference type="OMA" id="ITECIIM"/>
    <dbReference type="OrthoDB" id="5370059at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="560"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="620"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="758"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="847"/>
            <end position="874"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="891" mass="102415" checksum="04137E5EA36B6A45" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPW9</accession>
    <name>A3FPW9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Myosin-related protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_4340</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388348.1">
        <property type="nucleotide sequence ID" value="XM_001388311.1"/>
    </dbReference>
    <dbReference type="SMR" id="A3FPW9"/>
    <dbReference type="STRING" id="353152.A3FPW9"/>
    <dbReference type="GeneID" id="3375973"/>
    <dbReference type="KEGG" id="cpv:cgd6_4340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4340"/>
    <dbReference type="InParanoid" id="A3FPW9"/>
    <dbReference type="OMA" id="GADDMCE"/>
    <dbReference type="OrthoDB" id="10249697at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.240.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004009">
        <property type="entry name" value="SH3_Myosin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF752">
        <property type="entry name" value="MYOSIN-M HEAVY CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51844">
        <property type="entry name" value="SH3_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 7" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin N-terminal SH3-like" evidence="10">
        <location>
            <begin position="12"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Myosin motor" evidence="9">
        <location>
            <begin position="67"/>
            <end position="869"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="7">
        <location>
            <begin position="731"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="999"/>
            <end position="1061"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1088"/>
            <end position="1115"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1186"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="1281"/>
            <end position="1368"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="181"/>
            <end position="188"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51844"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1480" mass="170082" checksum="512AA8C47DEDD1BC" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPY8</accession>
    <name>A3FPY8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_2360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388429.1">
        <property type="nucleotide sequence ID" value="XM_001388392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPY8"/>
    <dbReference type="GeneID" id="3374648"/>
    <dbReference type="KEGG" id="cpv:cgd8_2360"/>
    <dbReference type="InParanoid" id="A3FPY8"/>
    <dbReference type="OMA" id="WIYLWRN"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAZ51469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="63" mass="7640" checksum="529D9A16323F70A1" modified="2007-04-03" version="1" fragment="single">YIYFSHIFIGSYNWIYLWRNQWCIPCTKIQELYGNSSLCCKSKTNSESNFVNNLIPLLDWWSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPZ3</accession>
    <name>A3FPZ3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_3170</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PTH2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388434.1">
        <property type="nucleotide sequence ID" value="XM_001388397.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPZ3"/>
    <dbReference type="FunCoup" id="A3FPZ3">
        <property type="interactions" value="513"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPZ3"/>
    <dbReference type="GeneID" id="3374653"/>
    <dbReference type="KEGG" id="cpv:cgd8_3170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3170"/>
    <dbReference type="InParanoid" id="A3FPZ3"/>
    <dbReference type="OMA" id="CRQTLNN"/>
    <dbReference type="OrthoDB" id="1733656at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd02430">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1490.10:FF:000001">
        <property type="entry name" value="Peptidyl-tRNA hydrolase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00283">
        <property type="entry name" value="arch_pth2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12649:SF11">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE 2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="102" mass="11126" checksum="174572C97F3D4E4A" modified="2007-04-03" version="1">MGRGKVASQCGHAVLGAYKKAIKRHPKMVEAWERSGQAKVVLKVSFKELLESERRAKEKNITSCLIKDAGRTQIAAGEYTAIAIGPGPSELIDEITGEYKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ21</accession>
    <name>A3FQ21_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 2 homolog</fullName>
            <ecNumber evidence="2">2.7.11.22</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">cgd3_1510</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.22"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="8">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.22" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51429.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388101.1">
        <property type="nucleotide sequence ID" value="XM_001388064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ21"/>
    <dbReference type="STRING" id="353152.A3FQ21"/>
    <dbReference type="GeneID" id="3374086"/>
    <dbReference type="KEGG" id="cpv:cgd3_1510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1510"/>
    <dbReference type="InParanoid" id="A3FQ21"/>
    <dbReference type="OMA" id="NWQIFVP"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000307">
        <property type="term" value="C:cyclin-dependent protein kinase holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030332">
        <property type="term" value="F:cyclin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004693">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000082">
        <property type="term" value="P:G1/S transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010389">
        <property type="term" value="P:regulation of G2/M transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000574">
        <property type="entry name" value="Cell division related protein kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000927">
        <property type="entry name" value="Cyclin-dependent kinase 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF254">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 14 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 15" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="28"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047811"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048367"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAZ51429.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="331" mass="37620" checksum="4BBC8EC2474410C5" modified="2007-04-03" version="1">MEVHSSTVGCQTECTSTFEDTQGLEKNYSMVRVIGEGTYGIVWEGLRKDTGEVVALKKIRFDSDEILDEVGLPSTAIREIVLLRELKHPNIVALLEVSCTGMQIWLIFEYCETDLRRYLRLNRKKGLSINQVKSLLRQLLSGLAFCHGKRILHRDLKPQNLLLSDSGNTLKIADFGLARTFTPPLKPNTHEVVTLWYRAPELLLGQRCYNCSVDLWSVGCIMVEMISGKPIFPGDSEIDTLFYIFRLLGTANESNWPGVTQLPCYKSVFPQWKVNPKLNLHALLPNLDQAGVDLLFRLLQYCPKKRITALEALQHPWLNTNTQNINVEMTI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ31</accession>
    <name>A3FQ31_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Steroid dehydrogenase kik-i, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_2370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388111.1">
        <property type="nucleotide sequence ID" value="XM_001388074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ31"/>
    <dbReference type="SMR" id="A3FQ31"/>
    <dbReference type="FunCoup" id="A3FQ31">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ31"/>
    <dbReference type="GeneID" id="3374076"/>
    <dbReference type="KEGG" id="cpv:cgd3_2370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2370"/>
    <dbReference type="InParanoid" id="A3FQ31"/>
    <dbReference type="OMA" id="LVAPGMM"/>
    <dbReference type="OrthoDB" id="1393670at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05356">
        <property type="entry name" value="17beta-HSD1_like_SDR_c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051019">
        <property type="entry name" value="VLCFA-Steroid_DH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43899:SF13">
        <property type="entry name" value="RH59310P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000126">
        <property type="entry name" value="11-beta-HSD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="234" mass="26463" checksum="F9253A1235A41800" modified="2007-04-03" version="1">MNYLSMAINKLFLLLNRPEKKLTSFGSWAIITGASDGIGKAMAKELFKEDLNLILIGRNREKLQNVVNELLSLKKPDSNQEIRYYLMDFTDPTCYSNFCGYLNSIDDVGILINNVGISYPYAQYFEETSLDLINELIEVNVRSVLMMTRIVYSYMKKRDRGAILCIGSGSSQLQTDPLYSAYAATKSVAESLCRSLRAECESENITIQCHTPLLVTTKLSKAKRETLFTISTKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ58</accession>
    <name>A3FQ58_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_910</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388194.1">
        <property type="nucleotide sequence ID" value="XM_001388157.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ58"/>
    <dbReference type="STRING" id="353152.A3FQ58"/>
    <dbReference type="GeneID" id="3373425"/>
    <dbReference type="KEGG" id="cpv:cgd2_910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_910"/>
    <dbReference type="InParanoid" id="A3FQ58"/>
    <dbReference type="OMA" id="TINIHYT"/>
    <dbReference type="OrthoDB" id="10252171at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF24">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein kinase" evidence="1">
        <location>
            <begin position="7"/>
            <end position="374"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="376" mass="43602" checksum="F0D5C987549DCF7B" modified="2007-04-03" version="1">MKFPNTLEIKEKISKRVFNAKYKSQDVVLKLFTPDDLDGCAAQIKHVFDEYEGTDCDYLETSLDDRVLYCINIHYLIQRKLGISMTSEYYRKDMQEWVFETIVDGQRDYLESSLSEENRSRTSKDMKNSFIQLIHVFGVRFDQKSQVFTSQDQFIGLIFPKLGQPLMNFAQNQRWVPNPIYLSSVFSDELSIAHIFKDVVKSALFLLRELNIVHKDIKIENICTVLDNPESNKIHPIIIDFGESQILSNNGMLRDAYGTHTMLPPEAFTYSFCSHNDENYMGYSAEKREVWTLGCLLHTLVFGYPPYFDIFSKKSPIEFQLKLCDESITIDIPTYSSVLNADISHNLRNLLSSILVKAPNNRLCLENILLHPWLQP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQC3</accession>
    <name>A3FQC3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd1_700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388145.1">
        <property type="nucleotide sequence ID" value="XM_001388108.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQC3"/>
    <dbReference type="GeneID" id="3371497"/>
    <dbReference type="KEGG" id="cpv:cgd1_700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_700"/>
    <dbReference type="InParanoid" id="A3FQC3"/>
    <dbReference type="OMA" id="ACAQWFH"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000838">
        <property type="entry name" value="ABC multidrug transporter (Eurofung)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF399">
        <property type="entry name" value="ABC TRANSPORTER ATNG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="266"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="347"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="376"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="843"/>
            <end position="865"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="877"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="968"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1064"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1089"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="251"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="439"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="843"/>
            <end position="1122"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1192"/>
            <end position="1426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1431" mass="162219" checksum="90A820F30959E258" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQE4</accession>
    <name>A3FQE4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="6">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_2360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388166.1">
        <property type="nucleotide sequence ID" value="XM_001388129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQE4"/>
    <dbReference type="FunCoup" id="A3FQE4">
        <property type="interactions" value="373"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQE4"/>
    <dbReference type="GeneID" id="3371404"/>
    <dbReference type="KEGG" id="cpv:cgd1_2360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2360"/>
    <dbReference type="InParanoid" id="A3FQE4"/>
    <dbReference type="OMA" id="QSTMPID"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07415">
        <property type="entry name" value="MPP_PP2A_PP4_PP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000005">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047129">
        <property type="entry name" value="PPA2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45619">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="7">
        <location>
            <begin position="108"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00038328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="304" mass="35153" checksum="476951FD07A5EB59" modified="2007-04-03" version="1">MSDLDRQIEQLRRCEPIKESEVKLLCMKAREILVEEANVQRIDTPVTICGDIHGQFFDLMELFKVGGELPDTNYLFLGDFVDRGYYSVETFLLLIALKVRYPDRIMLIRGNHETRQITQVYGFYDECLRKYGSVNVWRYCTEIFDYLSLASLIEDRILCVHGGLSPSIATIDEIRSLDRKQEVPHDGSMCDLLWSDPEEINGWGISPRGAGYIFGSDVVKSFNHCNDIELITRAHQLAMDGYKWWFEQNLVTVWSAPNYCYRCGNIATVMELDEQLNYHFKTFEAAPAEQRGIPAKRPAPDYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQJ6</accession>
    <name>A3FQJ6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Doublecortin domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_3050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388280.1">
        <property type="nucleotide sequence ID" value="XM_001388243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQJ6"/>
    <dbReference type="STRING" id="353152.A3FQJ6"/>
    <dbReference type="GeneID" id="3373326"/>
    <dbReference type="KEGG" id="cpv:cgd5_3050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3050"/>
    <dbReference type="InParanoid" id="A3FQJ6"/>
    <dbReference type="OMA" id="FRNGDEH"/>
    <dbReference type="OrthoDB" id="548799at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046785">
        <property type="term" value="P:microtubule polymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01617">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.230">
        <property type="entry name" value="Doublecortin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003533">
        <property type="entry name" value="Doublecortin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036572">
        <property type="entry name" value="Doublecortin_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008907">
        <property type="entry name" value="TPP/p25"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03607">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05517">
        <property type="entry name" value="p25-alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00537">
        <property type="entry name" value="DCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89837">
        <property type="entry name" value="Doublecortin (DC)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50309">
        <property type="entry name" value="DC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Doublecortin" evidence="2">
        <location>
            <begin position="159"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50309"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="251" mass="29152" checksum="F9E24D3C90E763B2" modified="2007-04-03" version="1">MHARRLNSTKLEEITYLPEEEDILIWHSKSLESKEKSNLEHRHSSKAKKNSNNLKLQTKLISSPDTEKQTKLVNKFHTIPEDSKTSVFDRLLDPKLYTGMHKYRFDKDGNGLGKAGREYLFREDGYTESTKRKHEVVSSSIKRHSYANISSNDFLQKAKVIWLYKNGDKYDKGTIYYVKPYIRNMTQLLNEINRNVRLLGGPVRALYDQGLKQINGVSEIVDGAKYLCTSGEQPTSIEKLEKFLSYWIINK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQM2</accession>
    <name>A3FQM2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Mob1/phocein family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_3350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388077.1">
        <property type="nucleotide sequence ID" value="XM_001388040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQM2"/>
    <dbReference type="STRING" id="353152.A3FQM2"/>
    <dbReference type="GeneID" id="3372774"/>
    <dbReference type="KEGG" id="cpv:cgd4_3350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3350"/>
    <dbReference type="InParanoid" id="A3FQM2"/>
    <dbReference type="OMA" id="NERFHIV"/>
    <dbReference type="OrthoDB" id="8170117at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.140.30">
        <property type="entry name" value="MOB kinase activator"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005301">
        <property type="entry name" value="MOB_kinase_act_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036703">
        <property type="entry name" value="MOB_kinase_act_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22599">
        <property type="entry name" value="MPS ONE BINDER KINASE ACTIVATOR-LIKE MOB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03637">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01388">
        <property type="entry name" value="Mob1_phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101152">
        <property type="entry name" value="Mob1/phocein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAZ51265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="369" mass="41849" checksum="D99837562B21C12C" modified="2007-04-03" version="1">MATNNKQPMDTVMKAPISCDVLSQTFDTSILYEAVKNPEGINRDEWAAHKVMDLFKDAQMAWGFVSNVCHCPLMRAHFMVFKWQEDPKKAALPLPATVYIKSLFLWVDSQISDTRIFPLKPGVPFTDDFQLIVKNILRRLFRVYSHIYCHHWTHVESITATAHVNYCLKHFVYTVMLNNLLECNELKPLEELANHIMEEGLNFGQNSVILANRIQEKDSNQECQKTQVNSVLVKADISSPDTHIPSTNSLTADSPISEDRIEISHTIPNSGEDSTITKSIKANISSYPQDISKTQNVGRVQSTCSDSMLITTSKSRADKKDNSIHSRKIKTYPWTELAKKLILCTKRKKKDGKLFISGFLTPKATSENL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQQ9</accession>
    <name>A3FQQ9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">ABC transporter family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_60</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAZ51210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388185.1">
        <property type="nucleotide sequence ID" value="XM_001388148.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQQ9"/>
    <dbReference type="GeneID" id="3372353"/>
    <dbReference type="KEGG" id="cpv:cgd2_60"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_60"/>
    <dbReference type="InParanoid" id="A3FQQ9"/>
    <dbReference type="OMA" id="RLEIYMC"/>
    <dbReference type="OrthoDB" id="4865934at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="267"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="363"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="876"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="921"/>
            <end position="940"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1105"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1131"/>
            <end position="1152"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="86"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="484"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="906"/>
            <end position="1123"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="1300"/>
            <end position="1540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1174"/>
            <end position="1209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="1174"/>
            <end position="1203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAZ51210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="15">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1541" mass="174538" checksum="9EBE7C714AB83BD6" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPW0</accession>
    <name>Q5CPW0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secrted alpha/beta hydrolase superfamiy protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_625519.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q5CPW0">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPW0"/>
    <dbReference type="ESTHER" id="crypv-q5cpw0">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="MEROPS" id="S33.010"/>
    <dbReference type="GeneID" id="3372461"/>
    <dbReference type="KEGG" id="cpv:cgd8_600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_600"/>
    <dbReference type="InParanoid" id="Q5CPW0"/>
    <dbReference type="OMA" id="ECCHLVI"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="2">
        <location>
            <begin position="64"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="417"/>
        </location>
    </feature>
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        <location>
            <begin position="374"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="391"/>
            <end position="407"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="417" mass="47577" checksum="0AA5431B1B3FCC51" modified="2005-04-12" version="1">MWLFKYIFAIISFAYVGIFKVYGEEQKVIPDHFYFEEGSKIQLSHGIVNYQLHKENDDGPISVCLHCFMGTISDCSSISKNLAKNGYRALRFDFYGHGLSQYKNFGQYSVDDYVDQTMELLEKLGLYNVTAISEEELHSSSFIPKLHVIGTSLGGFVAMRIAQRFPKHISKLVLDAPPGLLKKKVAPYLQYSIINYPLQLFANIYSPVWGCYQFMDPPSENLSSPKLDFRAKHYCKQILLTSLQLFLGINLWNNQQIYQEFSKVDVPTLFFWGAEDRLCPLSSAITILNEYVPNTKIIVYENCKHRCSKYCKEQFVEDVIKYFNNELDQELVSMSQYYNSVHDIVHSSEKRSLPSIRGTKTDTLLEPSSIPEDTCSTSTSGSQEIAVQLASSTEENTETGSSMSSSENFDDFCKTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ24</accession>
    <name>Q5CQ24_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_4410</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625602.1">
        <property type="nucleotide sequence ID" value="XM_625602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ24"/>
    <dbReference type="GeneID" id="3372547"/>
    <dbReference type="KEGG" id="cpv:cgd5_4410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4410"/>
    <dbReference type="InParanoid" id="Q5CQ24"/>
    <dbReference type="OMA" id="KQNTHIV"/>
    <dbReference type="OrthoDB" id="344028at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="83"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="182"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="262"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="275"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="319" mass="37869" checksum="F54FA08585042263" modified="2005-04-12" version="1">MSESNKENKAKKARSAGQRIRDIKRLLENKKFQISEEKKIELEEEAKVLKDTISKNNSSYKKKLNKYLQYKKNKQKTMRFVELVKVKRKINQLQKDLVEILRNNEIEEEIQQDENNSDIDNAEGNPKECLDLSFSENDTVRDKILKIKSKILVYKRYEDYIRLLPFFKERKYIPLFSNTELDSEMIKRREEYINDVQELKEELRRKKIKTSEINNLSLKDSFLAQDDSDDLECDQNLNKEHDTLKRPIKKIEYMIGGNQTRNSSNTKKSSNKINVKKDKDKYKDKYKDKSNSNNYPISESETKTKIKPSNSHVIFSDSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ42</accession>
    <name>Q5CQ42_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane associated protein with a signal peptide, EGF domain and 7 transmembrane domains at the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_4220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625584.1">
        <property type="nucleotide sequence ID" value="XM_625584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ42"/>
    <dbReference type="GeneID" id="3372568"/>
    <dbReference type="KEGG" id="cpv:cgd5_4220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4220"/>
    <dbReference type="InParanoid" id="Q5CQ42"/>
    <dbReference type="OrthoDB" id="420410at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899">
        <property type="entry name" value="DOMAIN OOKINETE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899:SF1">
        <property type="entry name" value="PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="27"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="39"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="482" mass="53281" checksum="CF947178EA1A2F21" modified="2005-04-12" version="1">MAIIDLASLCSPIHTFKRGLIFAQNQNSPSKDQGFETLNNSQSRIHSNSNSSLGAQGDISNYATLNATHLKTKGEYSIPGRNIEYNSNPNSSSLETARSELGAGTGAVIGTGAIIGTGAGIGTGAGIGAGTILGPSTSLGLVSGLGQKSESSSNYESNKSETKLGCHLKTNQESAVLVKQIPNNQTQRGGLNLMKITQNIQSYGYRYNYDNLNIFANHNNLNTNTYQKNTIAIFDLDDTLIPTDWIRDTYTKIRQNPALSYLFSNSSNNVYQYIRMQIDQQVNYQLIPSIIRILSYAKNMFLDVAIVTNARSTGWLKVVDTMFPELSNALNELGIQIIRTNPIGQEPDIEDGEKYFNYWMLAKKFEFEKIVTRWTSNIDNIKLDLISIGDNDFEECAAVHLAVVDKAVRYSKIIRCSSGLSPKAFITQLQAISNAIEIERKRNSSHSWINYSNTVSSIIIESGQPFNSETMNIFEDYSTEDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ68</accession>
    <name>Q5CQ68_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625558.1">
        <property type="nucleotide sequence ID" value="XM_625558.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ68"/>
    <dbReference type="GeneID" id="3372600"/>
    <dbReference type="KEGG" id="cpv:cgd5_3940"/>
    <dbReference type="InParanoid" id="Q5CQ68"/>
    <dbReference type="OrthoDB" id="441724at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253739" evidence="1">
        <location>
            <begin position="18"/>
            <end position="265"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="265" mass="30686" checksum="4851AD28D44293D3" modified="2005-04-12" version="1">MNATLFFLILFLVYAKSQKPIKNEIELRENENIKIPVFLDNFSNKLGLDLVIGKKTVRLVIDTLNEGIRLFQDGTEACNKGKLSYSFRSGTGFEDDSEISRIGKSQSNNDSCYDPLSSDSASWCYNKDHCRISYYMDSYTCEKKKEFPDTRENGIFNAFFHSNERVYDGISKFEVMLEGNELVIIPWMVPELVLQEFPIKLIKSDLSTGNGENWPSFHNFDGFIGLVGKLIFFYYLEWETGSRLSYLKLNHIFIALSLIYQLYYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQB9</accession>
    <name>Q5CQB9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_1320</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TMCO4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87616.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625729.1">
        <property type="nucleotide sequence ID" value="XM_625729.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQB9"/>
    <dbReference type="ESTHER" id="crypv-q5cqb9">
        <property type="family name" value="Duf_726"/>
    </dbReference>
    <dbReference type="GeneID" id="3372643"/>
    <dbReference type="KEGG" id="cpv:cgd4_1320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1320"/>
    <dbReference type="InParanoid" id="Q5CQB9"/>
    <dbReference type="OMA" id="DIYMTER"/>
    <dbReference type="OrthoDB" id="277931at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007941">
        <property type="entry name" value="DUF726"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920:SF3">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17920">
        <property type="entry name" value="TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4 TMCO4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05277">
        <property type="entry name" value="DUF726"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="463"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="527"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87616.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="801" mass="91251" checksum="A8357CC967057788" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQG8</accession>
    <name>Q5CQG8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">DNA topoisomerase 2</fullName>
            <ecNumber evidence="13">5.6.2.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd4_780</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 12 13">
            <text>ATP-dependent breakage, passage and rejoining of double-stranded DNA.</text>
            <dbReference type="EC" id="5.6.2.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 13">Belongs to the type II topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.2" evidence="13"/>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87659.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625680.1">
        <property type="nucleotide sequence ID" value="XM_625680.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CQG8">
        <property type="interactions" value="316"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQG8"/>
    <dbReference type="GeneID" id="3372744"/>
    <dbReference type="KEGG" id="cpv:cgd4_780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_780"/>
    <dbReference type="InParanoid" id="Q5CQG8"/>
    <dbReference type="OMA" id="TWTQDFK"/>
    <dbReference type="OrthoDB" id="276498at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003918">
        <property type="term" value="F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000819">
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
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    </dbReference>
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        <property type="entry name" value="Topoisomerase II, domain 5"/>
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        <property type="entry name" value="Topoisomerase, domain 3"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="HATPase_C_sf"/>
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        <property type="entry name" value="HATPase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
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        <property type="entry name" value="Topo_IIA_A/C_ab"/>
    </dbReference>
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        <property type="entry name" value="Topo_IIA_A_a_sf"/>
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        <property type="entry name" value="DNA TOPOISOMERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10169">
        <property type="entry name" value="DNA TOPOISOMERASE/GYRASE"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="DNA_gyraseB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00521">
        <property type="entry name" value="DNA_topoisoIV"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02518">
        <property type="entry name" value="HATPase_c"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16898">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01158">
        <property type="entry name" value="TOPISMRASEII"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00418">
        <property type="entry name" value="TPI2FAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00433">
        <property type="entry name" value="TOP2c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00434">
        <property type="entry name" value="TOP4c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56719">
        <property type="entry name" value="Type II DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52040">
        <property type="entry name" value="TOPO_IIA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00177">
        <property type="entry name" value="TOPOISOMERASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="10 12 13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11 12 13" id="KW-0413">Isomerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12 13" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="16">
        <location>
            <begin position="580"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IIA-type catalytic" evidence="17">
        <location>
            <begin position="832"/>
            <end position="1400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="297"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1022"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1436"/>
            <end position="1657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1681"/>
            <end position="1797"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="1370"/>
            <end position="1420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="297"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="333"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="369"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="384"/>
            <end position="396"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1438"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1450"/>
            <end position="1460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="15">
        <location>
            <begin position="1468"/>
            <end position="1479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1484"/>
            <end position="1509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1529"/>
            <end position="1548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="15">
        <location>
            <begin position="1610"/>
            <end position="1621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1622"/>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1645"/>
            <end position="1656"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1681"/>
            <end position="1693"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1706"/>
            <end position="1720"/>
        </location>
    </feature>
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        <location>
            <begin position="1726"/>
            <end position="1737"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="1752"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="active site" description="O-(5'-phospho-DNA)-tyrosine intermediate" evidence="12">
        <location>
            <position position="922"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU362094"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS52040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAK87659.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1797" mass="204211" checksum="E7A7D707E5968DC0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQH3</accession>
    <name>Q5CQH3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RRM domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF2/ABP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625675.1">
        <property type="nucleotide sequence ID" value="XM_625675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQH3"/>
    <dbReference type="FunCoup" id="Q5CQH3">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQH3"/>
    <dbReference type="GeneID" id="3372746"/>
    <dbReference type="KEGG" id="cpv:cgd4_710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_710"/>
    <dbReference type="InParanoid" id="Q5CQH3"/>
    <dbReference type="OMA" id="ILAIPHC"/>
    <dbReference type="OrthoDB" id="287393at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000447">
        <property type="term" value="P:endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034462">
        <property type="term" value="P:small-subunit processome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12263">
        <property type="entry name" value="RRM_ABT1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039119">
        <property type="entry name" value="ABT1/Esf2"/>
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    <dbReference type="InterPro" id="IPR034353">
        <property type="entry name" value="ABT1/ESF2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12311:SF7">
        <property type="entry name" value="ACTIVATOR OF BASAL TRANSCRIPTION 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0694">RNA-binding</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="178"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="224" mass="26382" checksum="A83E9F63985F875A" modified="2005-04-12" version="1">MTPEETTKELNKTNEKSEILSAFENAINDEKNRGIIYISRIPPKMQPHHIREIMSKFGEVDRIFLRPEDKSKHEQRVKMKGGNYIRYIDGWVEFKDKKVAKIVASSLNNTNVGGKKRHNAWRDDIWCIKYLSNFKWHNLTEHNRYLKSVRKTKLQARITQVQKENNFYLQQVEKAHRMKKSEKLDANNPTQQGNVDPNKSKTYEKPLIESNESKISQKSLISLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQM3</accession>
    <name>Q5CQM3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nucleolus and neural progenitor protein-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87699.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625625.1">
        <property type="nucleotide sequence ID" value="XM_625625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQM3"/>
    <dbReference type="GeneID" id="3372720"/>
    <dbReference type="KEGG" id="cpv:cgd4_160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_160"/>
    <dbReference type="InParanoid" id="Q5CQM3"/>
    <dbReference type="OrthoDB" id="114080at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="96"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87699.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="293" mass="33873" checksum="F2882E1486935547" modified="2005-04-12" version="1">MEKINYYCKALSQELKLLERVIYKFKNQHGRLGYFKSIFRITKELKLFYIALQETFYNNKSTENAENYYKNLKDLRKIVRRIKWDLKDAGTSISRLLSHGFFLTLVFLLFSILSRIFSVIINIKVTIDHIIPTIPVKSSHSNQSSSISINSHKNNKINSNFINKTSEPLQMQYFDEEVEDLGEVVSYSSIVEKSDIPLNSKNSTSLKISNDNNSLEPETDVKNSFIDLITEQVAEKEICSSNSLQNDATIHYENVDQDLVIQSTATNTNASIKLIRAWNSHMILRSKRRKLTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQN2</accession>
    <name>Q5CQN2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Extracellular membrane associated protein with a signal peptide, an EGF domain followed by 10 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_60</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87736.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625616.1">
        <property type="nucleotide sequence ID" value="XM_625616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQN2"/>
    <dbReference type="STRING" id="353152.Q5CQN2"/>
    <dbReference type="GeneID" id="3372667"/>
    <dbReference type="KEGG" id="cpv:cgd4_60"/>
    <dbReference type="InParanoid" id="Q5CQN2"/>
    <dbReference type="OMA" id="FCNYGEY"/>
    <dbReference type="OrthoDB" id="338325at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.50.10">
        <property type="entry name" value="Tumor Necrosis Factor Receptor, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002049">
        <property type="entry name" value="LE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01248">
        <property type="entry name" value="EGF_LAM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254412" evidence="2">
        <location>
            <begin position="34"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="239"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="511"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="551"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="588"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="domain" description="Laminin EGF-like" evidence="3">
        <location>
            <begin position="160"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87736.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="789" mass="89717" checksum="82C8DADC5023E65D" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQS4</accession>
    <name>Q5CQS4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_3520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625928.1">
        <property type="nucleotide sequence ID" value="XM_625928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQS4"/>
    <dbReference type="STRING" id="353152.Q5CQS4"/>
    <dbReference type="GeneID" id="3372861"/>
    <dbReference type="KEGG" id="cpv:cgd4_3520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3520"/>
    <dbReference type="InParanoid" id="Q5CQS4"/>
    <dbReference type="OMA" id="NSPYNYP"/>
    <dbReference type="OrthoDB" id="344168at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254416" evidence="2">
        <location>
            <begin position="27"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="441"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="495"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="656"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="775"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="441"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="451"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="563"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="583"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="661"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="676"/>
            <end position="686"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="687"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="777"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="790"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="807"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="838"/>
            <end position="857"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1002" mass="113078" checksum="8AD7E21C27173243" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQS6</accession>
    <name>Q5CQS6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_3500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625926.1">
        <property type="nucleotide sequence ID" value="XM_625926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQS6"/>
    <dbReference type="GeneID" id="3372858"/>
    <dbReference type="KEGG" id="cpv:cgd4_3500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3500"/>
    <dbReference type="InParanoid" id="Q5CQS6"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="138" mass="16462" checksum="02736A2396C96340" modified="2005-04-12" version="1">MYMLLKKILLSIFFLNWFLIIKRIKGIDLNDDKEILIRELGIPLRMKPFGENRVPSLRNFNYKTQGENNNYRVEINNLYINDRFQLSYYLKIGDKNAKFLSCGFKFRFNNTTLPMLVNRGEVSFNKLKKKGNYFSSIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQS7</accession>
    <name>Q5CQS7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625925.1">
        <property type="nucleotide sequence ID" value="XM_625925.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQS7"/>
    <dbReference type="GeneID" id="3372862"/>
    <dbReference type="KEGG" id="cpv:cgd4_3490"/>
    <dbReference type="InParanoid" id="Q5CQS7"/>
    <dbReference type="OMA" id="RMSKEAD"/>
    <dbReference type="OrthoDB" id="343778at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="424" mass="49745" checksum="29A9B65E4C2E4CE4" modified="2005-04-12" version="1">MMVVNKRYLIYIYIIVFFGVFHSFTKEITCSVIVKFFRIIKEQKEKFKPYEERTPKISKQSELSEFEKRQLYWYYKDYIGIKEINKIWKIKNNNNNNITDEEIFSNKSFIPIINEFSRFGQPIQNNFKNNTANSINNDFGIGTLEKSNVIFYRGDNKLNLNNLGKLEKEDQLNINLKENSEYIWASLISPCDGEIQFNIELEETLIFHENKSLYIIYCMNGNIKERYSPFKGKVIEFLNGRMILNISDNINSKLDLNKKFFVRKGEVILRILENYYPPIFESNLIAIPLFMPCNGRVAWGKEHGKVFVKGEQIVEFICIEKEKIVIKHLISPSRGYTESLQQNKSENKTTINFLDQSFNSPIIQIADPIGIMWLELNGINLGEERFPSSSKEILIKMPCNGRIEYPISESSFVLKNEVSHQVFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQU6</accession>
    <name>Q5CQU6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 9">tRNA (guanine(26)-N(2))-dimethyltransferase</fullName>
            <ecNumber evidence="7 9">2.1.1.216</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_3250</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>guanosine(26) in tRNA + 2 S-adenosyl-L-methionine = N(2)-dimethylguanosine(26) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:43140"/>
            <dbReference type="Rhea" id="RHEA-COMP:10359"/>
            <dbReference type="Rhea" id="RHEA-COMP:10360"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74513"/>
            <dbReference type="EC" id="2.1.1.216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.216" evidence="7 9"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87796.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625906.1">
        <property type="nucleotide sequence ID" value="XM_625906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQU6"/>
    <dbReference type="FunCoup" id="Q5CQU6">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQU6"/>
    <dbReference type="GeneID" id="3372784"/>
    <dbReference type="KEGG" id="cpv:cgd4_3250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3250"/>
    <dbReference type="InParanoid" id="Q5CQU6"/>
    <dbReference type="OMA" id="PNPTPYW"/>
    <dbReference type="OrthoDB" id="6349953at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160104">
        <property type="term" value="F:tRNA (guanine(26)-N2)-dimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002940">
        <property type="term" value="P:tRNA N2-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.70">
        <property type="entry name" value="N2,N2-dimethylguanosine tRNA methyltransferase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002905">
        <property type="entry name" value="Trm1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042296">
        <property type="entry name" value="tRNA_met_Trm1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631">
        <property type="entry name" value="N 2 ,N 2 -DIMETHYLGUANOSINE TRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10631:SF3">
        <property type="entry name" value="TRNA (GUANINE(26)-N(2))-DIMETHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02005">
        <property type="entry name" value="TRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51626">
        <property type="entry name" value="SAM_MT_TRM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 9 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3 9 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 9" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="1 9" id="KW-0820">tRNA-binding</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00039099"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00051897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87796.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="637" mass="71322" checksum="CD3C2102D47AB81C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQV8</accession>
    <name>Q5CQV8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Guanylate cyclase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_3100</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625894.1">
        <property type="nucleotide sequence ID" value="XM_625894.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CQV8">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQV8"/>
    <dbReference type="GeneID" id="3372791"/>
    <dbReference type="KEGG" id="cpv:cgd4_3100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3100"/>
    <dbReference type="InParanoid" id="Q5CQV8"/>
    <dbReference type="OMA" id="THDRCEN"/>
    <dbReference type="OrthoDB" id="194468at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009190">
        <property type="term" value="P:cyclic nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47455">
        <property type="entry name" value="ADENYLYL CYCLASE BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47455:SF1">
        <property type="entry name" value="GUANYLATE CYCLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="123"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="425"/>
            <end position="557"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="224"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="606"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="918"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1567"/>
            <end position="1607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="625"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="642"/>
            <end position="653"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="921"/>
            <end position="937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1577"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1591"/>
            <end position="1606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1631" mass="183034" checksum="F08D3BFF1C90D49C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQW2</accession>
    <name>Q5CQW2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3060</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625890.1">
        <property type="nucleotide sequence ID" value="XM_625890.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQW2"/>
    <dbReference type="GeneID" id="3372794"/>
    <dbReference type="KEGG" id="cpv:cgd4_3060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3060"/>
    <dbReference type="InParanoid" id="Q5CQW2"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="108"/>
            <end position="129"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="130" mass="15828" checksum="CC7292386B843BE7" modified="2005-04-12" version="1">MRFIPQSQFPDLFSYIDFFKYFLIYFSFHMFFEYLYMWNTHKIIYRLIRLVKNNPTIFKCNNNNNCSIKALYAIKNTSKFKSFTRALLSQLIIYMHISVYLYSFIFAMKYLCKIINVCLLFISIFLSALK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQZ2</accession>
    <name>Q5CQZ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PWP1 family protein with WD40 repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd4_2750</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625860.1">
        <property type="nucleotide sequence ID" value="XM_625860.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQZ2"/>
    <dbReference type="FunCoup" id="Q5CQZ2">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQZ2"/>
    <dbReference type="GeneID" id="3372837"/>
    <dbReference type="KEGG" id="cpv:cgd4_2750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2750"/>
    <dbReference type="InParanoid" id="Q5CQZ2"/>
    <dbReference type="OMA" id="TPESTIW"/>
    <dbReference type="OrthoDB" id="270624at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044285">
        <property type="entry name" value="PWP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14091:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="200"/>
            <end position="242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="429" mass="47603" checksum="81E978544A29F871" modified="2005-04-12" version="1">MDCNAVSSLSWVPRGYAKEVPIKNAHYAMNDEDVEQYFVSHNIEHEINNQTKTIIDTNLNTSGRDDKNSKDFSFYGENFFHTVERGLSKFGKDPNMKQDQFIDSDDEALQIKAGDSLLATTTIEDDVATLQVYLYSIEDGSFYVHHDVIIGDYPLCSEWISLGSHNKNNIVAVGSFNGEVNLWNLDFIDSIDPILTLHSDLGHSDAVMSLAAHNGNSKLLASGSADETIKLWDLNEGSCIITYSNSTNKVQCLEWHHSENNILIAADYNRSLQFIDIRTVGRQALLNYNKEHGDPESIVLPSAGIYDNGNTVIISTENGLISGYDIRMLSENCAKSKFSVVANHNSKPITSICCTSISNMLVSCDLDGISKVWDLSHMKECVIEKPLKGGKLFTCKSCPDEKAIVAFGGESTILWNISQEDVVSKKFDL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR33</accession>
    <name>Q5CR33_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Ubiquitin-activating enzyme E1 (UBA)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_2300</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the ubiquitin-activating E1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625819.1">
        <property type="nucleotide sequence ID" value="XM_625819.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR33"/>
    <dbReference type="FunCoup" id="Q5CR33">
        <property type="interactions" value="311"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR33"/>
    <dbReference type="GeneID" id="3372980"/>
    <dbReference type="KEGG" id="cpv:cgd4_2300"/>
    <dbReference type="InParanoid" id="Q5CR33"/>
    <dbReference type="OMA" id="GANLHAF"/>
    <dbReference type="OrthoDB" id="10252231at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031510">
        <property type="term" value="C:SUMO activating enzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019948">
        <property type="term" value="F:SUMO activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004839">
        <property type="term" value="F:ubiquitin activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016925">
        <property type="term" value="P:protein sumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01491">
        <property type="entry name" value="Ube1_repeat1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01490">
        <property type="entry name" value="Ube1_repeat2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.50.80:FF:000005">
        <property type="entry name" value="Ubiquitin-activating enzyme E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.180:FF:000002">
        <property type="entry name" value="Ubiquitin-activating enzyme E1 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.180">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, FCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.80">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12550">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, inactive adenylation domain, subdomain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2660">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, SCCH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.60">
        <property type="entry name" value="Ubiquitin-activating enzyme E1, UFD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042302">
        <property type="entry name" value="E1_FCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018965">
        <property type="entry name" value="Ub-activating_enz_E1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042449">
        <property type="entry name" value="Ub-E1_IAD_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038252">
        <property type="entry name" value="UBA_E1_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019572">
        <property type="entry name" value="UBA_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042063">
        <property type="entry name" value="Ubi_acti_E1_SCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018075">
        <property type="entry name" value="UBQ-activ_enz_E1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033127">
        <property type="entry name" value="UBQ-activ_enz_E1_Cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000011">
        <property type="entry name" value="UBQ/SUMO-activ_enz_E1-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01408">
        <property type="entry name" value="Ube1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF4">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09358">
        <property type="entry name" value="E1_UFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10585">
        <property type="entry name" value="UBA_E1_SCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01849">
        <property type="entry name" value="UBIQUITINACT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00985">
        <property type="entry name" value="UBA_e1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00865">
        <property type="entry name" value="UBIQUITIN_ACTIVAT_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0436">Ligase</keyword>
    <keyword evidence="4 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-activating enzyme E1 C-terminal" evidence="9">
        <location>
            <begin position="924"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="7">
        <location>
            <position position="619"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1067" mass="120522" checksum="6ED4918DAD34397F" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR42</accession>
    <name>Q5CR42_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Membrane associated aspartyl protease with a transmembrane domain at the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd4_2190</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87870.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625810.1">
        <property type="nucleotide sequence ID" value="XM_625810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR42"/>
    <dbReference type="STRING" id="353152.Q5CR42"/>
    <dbReference type="MEROPS" id="A01.075"/>
    <dbReference type="GeneID" id="3372952"/>
    <dbReference type="KEGG" id="cpv:cgd4_2190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2190"/>
    <dbReference type="InParanoid" id="Q5CR42"/>
    <dbReference type="OMA" id="RCNFASY"/>
    <dbReference type="OrthoDB" id="2747330at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd06096">
        <property type="entry name" value="Plasmepsin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033866">
        <property type="entry name" value="Plasmepsin_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032861">
        <property type="entry name" value="TAXi_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683">
        <property type="entry name" value="ASPARTYL PROTEASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13683:SF375">
        <property type="entry name" value="PEPTIDASE A1 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14543">
        <property type="entry name" value="TAXi_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 13" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0732">Signal</keyword>
    <keyword evidence="3 10 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="11">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254142" evidence="11">
        <location>
            <begin position="18"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="512"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="12">
        <location>
            <begin position="34"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00046288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK87870.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="550" mass="63533" checksum="6BD6A57A8558BF0B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR67</accession>
    <name>Q5CR67_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DUF676 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_1910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625785.1">
        <property type="nucleotide sequence ID" value="XM_625785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR67"/>
    <dbReference type="ESTHER" id="crypv-q5cr67">
        <property type="family name" value="Duf_676"/>
    </dbReference>
    <dbReference type="GeneID" id="3372892"/>
    <dbReference type="KEGG" id="cpv:cgd4_1910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1910"/>
    <dbReference type="InParanoid" id="Q5CR67"/>
    <dbReference type="OMA" id="NWITIQQ"/>
    <dbReference type="OrthoDB" id="10255013at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007751">
        <property type="entry name" value="DUF676_lipase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044294">
        <property type="entry name" value="Lipase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12482">
        <property type="entry name" value="LIPASE ROG1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05057">
        <property type="entry name" value="DUF676"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="DUF676" evidence="2">
        <location>
            <begin position="70"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="481" mass="55729" checksum="81F5B89AC4481819" modified="2005-04-12" version="1">MISYKEQKLNNLPENKYKSSLGSNDSFLESPNEGMSLEITFLISSIIICIVVSLISIVTQGKNQIRVNCSDPNHIVVMTHGWAGTPANMDVLAERILNKYNILDNSQWTENNQIQKSECILIYKIHSNWGYFRSIFITSDGIENGALRMSKELQQVIIRTPSLEKISFIGHSLGGLYNRAVLPLMSNYPLEKEIQSKNSTGLIGGLKPMNFISIGTPHKGVLSDDCTFFGFEILKVLFPWKWISWLPTISQLLLMDKNKPLIADMMNNMNMINPLSWFKHRHTIGSLKGDLLVPPTSASLLPFCIDNENLSLVSFNIYEFERRYQTNNIYRLKNFKQNYQLYSKTNKNHSNFVPNIIKAKSGEKDNLIEWITVIDSGNEKSYENKNEIYYRNIKNRKKLINLVKEKYHNFLNHKTLSDVFDKSPNGNLDKLVWMKTSVLFKSKIHRFFSHQLMMFCFENWGYFLLGNNFQLLDHIIENMKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR89</accession>
    <name>Q5CR89_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Brl1/Brr6 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_1680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625763.1">
        <property type="nucleotide sequence ID" value="XM_625763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR89"/>
    <dbReference type="GeneID" id="3372922"/>
    <dbReference type="KEGG" id="cpv:cgd4_1680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1680"/>
    <dbReference type="InParanoid" id="Q5CR89"/>
    <dbReference type="OMA" id="HNQNSTH"/>
    <dbReference type="OrthoDB" id="343714at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031965">
        <property type="term" value="C:nuclear membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055088">
        <property type="term" value="P:lipid homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006998">
        <property type="term" value="P:nuclear envelope organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040202">
        <property type="entry name" value="Brl1/Brr6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018767">
        <property type="entry name" value="Brl1/Brr6_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136:SF1">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRL1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28136">
        <property type="entry name" value="NUCLEUS EXPORT PROTEIN BRR6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10104">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01042">
        <property type="entry name" value="Brr6_like_C_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="domain" description="Brl1/Brr6" evidence="2">
        <location>
            <begin position="180"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="336" mass="39028" checksum="2F4E5BDF1B8B6BC6" modified="2005-04-12" version="1">MSNTVLEELEIEELSQKLMLKLSPKILKEEKFDEDMINAMIIDESSNGLVDNNFLNFDNKKNSEHIKTTDFINSFKPIDQKLNKENNDNLKPNLTINYKYIGNNCNKINQTLSNRSNSLPPRNNNYYCKGLNLLKKREIKAINNDFNSEKFNCNSFNQLSHGLNQNSYINSLKRMNIDNTHEFIRLIFNIIIVFITLYIIFGIIFVIKNDIESKIQISITNILDEMNICSKHYVDNKCHPEQRVPAMESKCTEWERCMSQNPTIIARKSIFTAQIIGEIINTFLDQISFKSALFIFGFIIALIIGNYFVLSSTFCFNRNINHTRNSLESTSIIKKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR93</accession>
    <name>Q5CR93_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_1630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87910.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625759.1">
        <property type="nucleotide sequence ID" value="XM_625759.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR93"/>
    <dbReference type="GeneID" id="3372926"/>
    <dbReference type="KEGG" id="cpv:cgd4_1630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1630"/>
    <dbReference type="InParanoid" id="Q5CR93"/>
    <dbReference type="OrthoDB" id="339343at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87910.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="212" mass="24887" checksum="8FBA6BB1888EA11A" modified="2005-04-12" version="1">MNEIYKWLILKRLFGEKKKSLNDNSKNLEKTMNKSGYCSEIAKNDYKKMEVEILGEPRIRRTCLSPRSTPIVLEINFCPKLLSEEKSLSKSLKVEWGATHDEIVTKKCFYFNNKQEENNCENLQNYENELSVAYLGRQNKRVYLEKNESIEMKILARNDDFDSTKVNLSKKSKLENTHSRHLDLGENNNNIKNYGNGGYEDLVLVEEWLFEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRD0</accession>
    <name>Q5CRD0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Large protein with 4 PHD domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_3300</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626256.1">
        <property type="nucleotide sequence ID" value="XM_626256.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRD0"/>
    <dbReference type="GeneID" id="3373048"/>
    <dbReference type="KEGG" id="cpv:cgd5_3300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3300"/>
    <dbReference type="InParanoid" id="Q5CRD0"/>
    <dbReference type="OMA" id="RSENIPC"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13832">
        <property type="entry name" value="zf-HC5HC2H_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="834"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="1102"/>
            <end position="1146"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="1278"/>
            <end position="1378"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger PHD-type" evidence="6">
        <location>
            <begin position="1508"/>
            <end position="1590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="106"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="645"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="106"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="122"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2084" mass="234625" checksum="F56FD73474C2E6E0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRI2</accession>
    <name>Q5CRI2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Predicted mannitol dehydrogenase zinc dependent alcohol dehydrogenase like rossmann fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_2670</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the zinc-containing alcohol dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626204.1">
        <property type="nucleotide sequence ID" value="XM_626204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRI2"/>
    <dbReference type="STRING" id="353152.Q5CRI2"/>
    <dbReference type="GeneID" id="3373207"/>
    <dbReference type="KEGG" id="cpv:cgd5_2670"/>
    <dbReference type="InParanoid" id="Q5CRI2"/>
    <dbReference type="OMA" id="EAIFPMV"/>
    <dbReference type="OrthoDB" id="1879366at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05283">
        <property type="entry name" value="CAD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000022">
        <property type="entry name" value="Cinnamyl alcohol dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.180.10">
        <property type="entry name" value="Medium-chain alcohol dehydrogenases, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013149">
        <property type="entry name" value="ADH-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013154">
        <property type="entry name" value="ADH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002328">
        <property type="entry name" value="ADH_Zn_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047109">
        <property type="entry name" value="CAD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020843">
        <property type="entry name" value="ER"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42683">
        <property type="entry name" value="ALDEHYDE REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08240">
        <property type="entry name" value="ADH_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00107">
        <property type="entry name" value="ADH_zinc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00829">
        <property type="entry name" value="PKS_ER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00059">
        <property type="entry name" value="ADH_ZINC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Enoyl reductase (ER)" evidence="6">
        <location>
            <begin position="24"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU361277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="365" mass="40057" checksum="AF85A061CF4C9DBD" modified="2005-04-12" version="1" fragment="single">LNIIFVEQKFKMAVYESKAYAALGPSQDLVPHKYEIKSYEPNEAKIKVLYCGICHSDVHQVKNEWFPGIFPMVPGHEIIGIVEEIGENVTKVKVGDCVGIGCIVDSCMSCNACKDGYEQFCGSLSLTYNGRYKNGMNTYGGYGTYVTCNEHFLLKIPENLDKAAAAPLLCAGVTVYSPMIRNKMNRPGFKLAVVGLGGLGHMAVKFGVSFGCEVAVITRSESKKEYALAMGAKHFIKFDDPEALEKFSGYFDGIIDTVSGKRSVENLLKLLSYHGVMACVGAPPAGETSEFNSFSVIFGEKTITGGNIGNIEITQQMLNYCGEHNITSTIELIKLNQVNEAYEKMLKSDVKFRFVIDVANSQDQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRW8</accession>
    <name>Q5CRW8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Nucleolar protein NOP4 rrm domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_1190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626068.1">
        <property type="nucleotide sequence ID" value="XM_626068.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRW8"/>
    <dbReference type="STRING" id="353152.Q5CRW8"/>
    <dbReference type="GeneID" id="3373096"/>
    <dbReference type="KEGG" id="cpv:cgd5_1190"/>
    <dbReference type="InParanoid" id="Q5CRW8"/>
    <dbReference type="OMA" id="NDHIFRH"/>
    <dbReference type="OrthoDB" id="3945418at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051945">
        <property type="entry name" value="RRM_MRD1_RNA_proc_ribogen"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039">
        <property type="entry name" value="RNA-BINDING MOTIF PROTEIN 14B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48039:SF5">
        <property type="entry name" value="RNA-BINDING PROTEIN 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="6">
        <location>
            <begin position="24"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="390" mass="45217" checksum="9102B8B188C18762" modified="2005-04-12" version="1" fragment="single">FYPKIVTMVEKTFRKITDDTDEGKTIFLRNIPFEMSEFSLKELIEGKFGETLYVKIVFSKLTQLPKGVAFVKFKNIESVEKVLEGEKVADRFYNDHIFRHKRKPISDSGNFSAIILPPEIGIQFNGRRIFARLALNRTEIANIESSKLSESSDKLSKNLDLLKKGLILPGMKEAEGISSHDLRLRENSWKEMKIKMSNPNYEVNKYRLCIRNIPTKIKSSELNDILIREISKMRDIEVQNLGHEIVSEFEKSENSNFKKILMSLRRNINSPKKCKLVFKRLINKVNIVRETSSKSSKSRGFAFVNTSSFSLSKSLLEALNNNPKIFTSEKRPIVEFAIEDKRALFIQKKRIENLKRREKKSSEICDKKPRKSYNISKVGRGRRQRIKNAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRX3</accession>
    <name>Q5CRX3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">DNMAP1 like Myb domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_1120</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626063.1">
        <property type="nucleotide sequence ID" value="XM_626063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRX3"/>
    <dbReference type="FunCoup" id="Q5CRX3">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRX3"/>
    <dbReference type="GeneID" id="3373071"/>
    <dbReference type="KEGG" id="cpv:cgd5_1120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1120"/>
    <dbReference type="InParanoid" id="Q5CRX3"/>
    <dbReference type="OMA" id="CEKYECH"/>
    <dbReference type="OrthoDB" id="19740at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035267">
        <property type="term" value="C:NuA4 histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000812">
        <property type="term" value="C:Swr1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032563">
        <property type="entry name" value="DAMP1_SANT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027109">
        <property type="entry name" value="Swc4/Dmap1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855:SF10">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12855">
        <property type="entry name" value="DNA METHYLTRANSFERASE 1-ASSOCIATED PROTEIN 1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16282">
        <property type="entry name" value="SANT_DAMP1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="DAMP1 SANT/Myb-like" evidence="7">
        <location>
            <begin position="135"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="445"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="458"/>
            <end position="468"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF16282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="576" mass="66501" checksum="C895AD4D46EDCCBE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS49</accession>
    <name>Q5CS49_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">G patch domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625987.1">
        <property type="nucleotide sequence ID" value="XM_625987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS49"/>
    <dbReference type="STRING" id="353152.Q5CS49"/>
    <dbReference type="GeneID" id="3373317"/>
    <dbReference type="KEGG" id="cpv:cgd5_240"/>
    <dbReference type="InParanoid" id="Q5CS49"/>
    <dbReference type="OMA" id="NGMWWEN"/>
    <dbReference type="OrthoDB" id="29523at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000467">
        <property type="entry name" value="G_patch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050656">
        <property type="entry name" value="PINX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23149">
        <property type="entry name" value="G PATCH DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01585">
        <property type="entry name" value="G-patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00443">
        <property type="entry name" value="G_patch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50174">
        <property type="entry name" value="G_PATCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="G-patch" evidence="2">
        <location>
            <begin position="30"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="167"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="113"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="124"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50174"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="189" mass="21211" checksum="165695E718F728DB" modified="2005-04-12" version="1" fragment="single">FIADIFKCKMSKNYFDKLNSGGLHSAIPFSSNIGINLLQKMGWTEGKGLGKEEVGMQECIQIKKKSDNLGLGAKVTRESSQDWSDWWKDAYNNVANKLSTNINDSRYEDLNSDDLSTDSEDESQSISSKSSKSSNSKKDKKKTKSKQKFESNVENITCKDDIIKVKKKTEKSDKKSKKSDKNKSKGNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS70</accession>
    <name>Q5CS70_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_10</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88201.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625966.1">
        <property type="nucleotide sequence ID" value="XM_625966.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS70"/>
    <dbReference type="STRING" id="353152.Q5CS70"/>
    <dbReference type="GeneID" id="3373339"/>
    <dbReference type="KEGG" id="cpv:cgd5_10"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_10"/>
    <dbReference type="InParanoid" id="Q5CS70"/>
    <dbReference type="OrthoDB" id="344096at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253787" evidence="2">
        <location>
            <begin position="21"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="105"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="170"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="191"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88201.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="576" mass="64764" checksum="F76A2C1000E54993" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS94</accession>
    <name>Q5CS94_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted protein of the alpha beta hydrolase superfamily, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_3610</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628173.1">
        <property type="nucleotide sequence ID" value="XM_628173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS94"/>
    <dbReference type="GeneID" id="3371519"/>
    <dbReference type="KEGG" id="cpv:cgd1_3610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3610"/>
    <dbReference type="InParanoid" id="Q5CS94"/>
    <dbReference type="OMA" id="CLAERIY"/>
    <dbReference type="OrthoDB" id="340906at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016042">
        <property type="term" value="P:lipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1090.10">
        <property type="entry name" value="Cytosolic phospholipase A2 catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016035">
        <property type="entry name" value="Acyl_Trfase/lysoPLipase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002641">
        <property type="entry name" value="PNPLA_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01734">
        <property type="entry name" value="Patatin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52151">
        <property type="entry name" value="FabD/lysophospholipase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51635">
        <property type="entry name" value="PNPLA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0442">Lipid degradation</keyword>
    <keyword evidence="1 2" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="21"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="PNPLA" evidence="4">
        <location>
            <begin position="149"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXGXXG" evidence="2">
        <location>
            <begin position="153"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="GXSXG" evidence="2">
        <location>
            <begin position="186"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="DGA/G" evidence="2">
        <location>
            <begin position="329"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="188"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="2">
        <location>
            <position position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="935" mass="108629" checksum="7508A7A0E7A0E152" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSR1</accession>
    <name>Q5CSR1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L36</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_1660</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL36 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628006.1">
        <property type="nucleotide sequence ID" value="XM_628006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSR1"/>
    <dbReference type="FunCoup" id="Q5CSR1">
        <property type="interactions" value="319"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSR1"/>
    <dbReference type="GeneID" id="3371640"/>
    <dbReference type="KEGG" id="cpv:cgd1_1660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1660"/>
    <dbReference type="InParanoid" id="Q5CSR1"/>
    <dbReference type="OMA" id="NKGHKTE"/>
    <dbReference type="OrthoDB" id="25649at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1760:FF:000001">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1760">
        <property type="entry name" value="60S ribosomal protein L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000509">
        <property type="entry name" value="Ribosomal_eL36"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038097">
        <property type="entry name" value="Ribosomal_eL36_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10114">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01158">
        <property type="entry name" value="Ribosomal_L36e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01190">
        <property type="entry name" value="RIBOSOMAL_L36E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006509"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000665"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="107" mass="12025" checksum="DF516B77D6410DDC" modified="2005-04-12" version="1">MTSSISTGTVVGLNTGFIVTKRPQRPRPSSRKGKLSARNALVRQVIREVAGFAPYEKRMMELLKVGSASTAKRAMRFARARLGTERRAKKKRDELVDIIQQQRKRAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSV7</accession>
    <name>Q5CSV7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted secreted protein, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627960.1">
        <property type="nucleotide sequence ID" value="XM_627960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSV7"/>
    <dbReference type="GeneID" id="3371604"/>
    <dbReference type="KEGG" id="cpv:cgd1_1160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1160"/>
    <dbReference type="InParanoid" id="Q5CSV7"/>
    <dbReference type="OMA" id="YSIVEVW"/>
    <dbReference type="OrthoDB" id="344060at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254208" evidence="1">
        <location>
            <begin position="23"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="297" mass="34740" checksum="12205E0D45562EBB" modified="2005-04-12" version="1">MRITFLAFLVVIFFFLVKTSKGEENEKLMKTSRRFLVQICKSLQISKNPEDLVNCYKSSIYFCEYLWVIAYIIEEKKSFKTQMILPKGVIDDKNCMEINFQQCITIANFLINESSISVEYNAINSMVSPVIEECNFENTNLLLSLNALWLKNSNKISDLTQGVIIGRGYQELVQFTNPFLDLSTIICQDVKMYLFTEKYKMKLKAVMKDLIQYKNLSLTIPDPVYVRLPLKYDEELDLNWLYCQDLPKYLNKLDEVSDQIKLDLRGKSLIINKDIITKCTLKNNNKVMKIITWKIIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT13</accession>
    <name>Q5CT13_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627904.1">
        <property type="nucleotide sequence ID" value="XM_627904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT13"/>
    <dbReference type="GeneID" id="3371545"/>
    <dbReference type="KEGG" id="cpv:cgd1_460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_460"/>
    <dbReference type="InParanoid" id="Q5CT13"/>
    <dbReference type="OMA" id="NPLHINI"/>
    <dbReference type="OrthoDB" id="343156at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="122"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="239"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="495"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="604" mass="71463" checksum="1FBA69B76D7B7CDD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT42</accession>
    <name>Q5CT42_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal peptide, predicted secreted protein with a cysteine cluster at the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_130</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627875.1">
        <property type="nucleotide sequence ID" value="XM_627875.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT42"/>
    <dbReference type="GeneID" id="3371435"/>
    <dbReference type="KEGG" id="cpv:cgd1_130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_130"/>
    <dbReference type="InParanoid" id="Q5CT42"/>
    <dbReference type="OrthoDB" id="344140at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254366" evidence="3">
        <location>
            <begin position="25"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="535"/>
            <end position="562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="266"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="297"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="323"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="354"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="432"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="469"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="493"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="513"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="690" mass="76653" checksum="ABCF016CF409C34C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT59</accession>
    <name>Q5CT59_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_4310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88612.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626610.1">
        <property type="nucleotide sequence ID" value="XM_626610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT59"/>
    <dbReference type="GeneID" id="3373709"/>
    <dbReference type="KEGG" id="cpv:cgd2_4310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4310"/>
    <dbReference type="InParanoid" id="Q5CT59"/>
    <dbReference type="OrthoDB" id="342756at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88612.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="161" mass="18518" checksum="9C9572538A26AD36" modified="2005-04-12" version="1">MSLFFHDYLSGSDDDCTAFEDSSVCKEGANEFKLSIVVNSGQLRSEKSDNFVACYEGNLQKKDQITPKTYIEPNLTKQISSKIGVKKKEKRKKKNKYLNEFYEISSIENVKTLDLDDLKKSDQAVGFPDNLSREKKLNADKELRQSCNQKRKHQVSITFIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT87</accession>
    <name>Q5CT87_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_4000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88635.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626582.1">
        <property type="nucleotide sequence ID" value="XM_626582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT87"/>
    <dbReference type="GeneID" id="3373393"/>
    <dbReference type="KEGG" id="cpv:cgd2_4000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4000"/>
    <dbReference type="InParanoid" id="Q5CT87"/>
    <dbReference type="OMA" id="HWNSDEM"/>
    <dbReference type="OrthoDB" id="336864at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="93"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88635.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="134" mass="15643" checksum="D782529E6DEBB233" modified="2005-04-12" version="1">MVVIVDQTKANFLFLIIASLGGISSVCRSDYNLPLFAFIWWSYFNLSENQKSRQQRFLRRFILLSCLQDIIFVLYWSPMWFSMQWKTNESSTFGSHILIITIAVINLFLKFITLFILKGGTGFASNQVIVYNNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTD6</accession>
    <name>Q5CTD6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">C-terminal region conserved, zinc finger, myb DNA binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_3460</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626533.1">
        <property type="nucleotide sequence ID" value="XM_626533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTD6"/>
    <dbReference type="STRING" id="353152.Q5CTD6"/>
    <dbReference type="GeneID" id="3373696"/>
    <dbReference type="KEGG" id="cpv:cgd2_3460"/>
    <dbReference type="InParanoid" id="Q5CTD6"/>
    <dbReference type="OMA" id="CHTKLAV"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="322"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="322"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="CHY-type" evidence="7">
        <location>
            <begin position="625"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="8"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="19"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="43"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="736" mass="83737" checksum="AB683114BA70F0AE" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTH5</accession>
    <name>Q5CTH5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">40S ribosomal protein S16</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_3000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uS9 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88714.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626494.1">
        <property type="nucleotide sequence ID" value="XM_626494.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTH5"/>
    <dbReference type="FunCoup" id="Q5CTH5">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTH5"/>
    <dbReference type="GeneID" id="3373458"/>
    <dbReference type="KEGG" id="cpv:cgd2_3000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3000"/>
    <dbReference type="InParanoid" id="Q5CTH5"/>
    <dbReference type="OMA" id="WPIEMAR"/>
    <dbReference type="OrthoDB" id="426865at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.230.10:FF:000007">
        <property type="entry name" value="40S ribosomal protein S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000754">
        <property type="entry name" value="Ribosomal_uS9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020574">
        <property type="entry name" value="Ribosomal_uS9_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001749">
        <property type="entry name" value="PRK00474.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569:SF16">
        <property type="entry name" value="RIBOSOMAL PROTEIN S16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21569">
        <property type="entry name" value="RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00380">
        <property type="entry name" value="Ribosomal_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00360">
        <property type="entry name" value="RIBOSOMAL_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88714.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="144" mass="16096" checksum="7ECD2896E5B0AE33" modified="2005-04-12" version="1">MTMESRMVQTFGRKKNAVAVALCREGKGLVHFNGKPLDLIQPEQLKVKAFEPILLLGKQIFSGVDIRIRVSGGGYTSQVFAIRQALAKAIVAYTQKFVDEATKQEIRDILVSYDRSLVIADPRRCEPKKFGGPGARARIQKSYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTK7</accession>
    <name>Q5CTK7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626462.1">
        <property type="nucleotide sequence ID" value="XM_626462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTK7"/>
    <dbReference type="GeneID" id="3373641"/>
    <dbReference type="KEGG" id="cpv:cgd2_2600"/>
    <dbReference type="InParanoid" id="Q5CTK7"/>
    <dbReference type="OrthoDB" id="342360at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="247" mass="28130" checksum="BA1D784581B96EF5" modified="2005-04-12" version="1">MIHKIKNFISIILFYIDIFQSFPYVNLRENQHISCFMQVGVHRRFVNPYRNKITVGPYDQEKTCKIACCSKKCYCATKQSSYSKRKHLDMPNCNYSNNLSPCSGCKGSSCTYSNLCNHSCPKNCNSSCFELHSSAFISCPNLSPNDLCLTFPRFKKNHSKKNCKCCTQFELSEDELVKIKNETGVFGKFNESSEITTESESSEIVDFEINMNKTSNSSEAKFSYDVSVNLFIIFNLTIALDLSSNYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTN8</accession>
    <name>Q5CTN8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_2270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Iowa type II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626431.1">
        <property type="nucleotide sequence ID" value="XM_626431.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTN8"/>
    <dbReference type="GeneID" id="3373515"/>
    <dbReference type="KEGG" id="cpv:cgd2_2270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2270"/>
    <dbReference type="InParanoid" id="Q5CTN8"/>
    <dbReference type="OMA" id="NEHSHFT"/>
    <dbReference type="OrthoDB" id="341377at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="345" mass="39286" checksum="811E045E07AA8FB9" modified="2005-04-12" version="1">MIFLTPLLSILSCFCLHYLWKYFEKEFGIITSLLSISIVIITFYGAYIYFKKSLYIEIDFGKFANKKEDFAEFNSNLMLSVFERYNRERENYLSGGLVTVKQGEDDPSEIKNKKFVSQSETHSSEMKDTDILFHDSKLSFFGLSMNSPNTSKKLYQHNNCYNSSHKICSPSLLADTFIQAADIARNYQSEHYRGIHNNSQLQNSNILIGSNTNTLAKAAETKNSNSRLFRSVGYSFHSNIEFARSRFEDYISSLQFRITNKRVRNSLPGRLLSSVSNSESGVKKNAISKHRKSSIPSILIESVDDKSTKAKANSSTPTRKIYNSFLSPLPTSKPSPILLFTDNKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTP0</accession>
    <name>Q5CTP0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626429.1">
        <property type="nucleotide sequence ID" value="XM_626429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTP0"/>
    <dbReference type="GeneID" id="3373517"/>
    <dbReference type="KEGG" id="cpv:cgd2_2240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2240"/>
    <dbReference type="InParanoid" id="Q5CTP0"/>
    <dbReference type="OMA" id="KIGRWHE"/>
    <dbReference type="OrthoDB" id="340447at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="461" mass="52159" checksum="D5CDB322F5EB8F99" modified="2005-04-12" version="1">MEGIQIPEIYINSDMILSFDEEACNWNETSSNLSNSPKILNTSIQNTSNKLNVNVNVNVNGNVNYNHSNSKCSFSTNNISEEVNASECNPKFLEIHRGNTNHKKISESISFSQEETPKSIIIDCLLKDQNQFKTENQYVESSQNLNLFSYLENNLTEKVNSDKFKSINKENNMVRRRRDDPKLCWRCHKRDATPHMRSCEPCRVADRQRWSRRRNLSKIISGKNVNNTNSEHSVNHFNNQLKDDSSISLCSDNPKIDTFNGGYIQNSTQLKCDNQYISNTNEHYRAFNTGISNANSSAQVTGFSVGYPFKTDQWREQQQSISFRENRNIHPCAEISQNLSYITISYFPSSFSGLTTLPVSAKFASDGSMNGLETLPSVVLSFIVDKCNEQLLQRQLGRQNHQNLVSGNTLCNSQVESGLGNILMSNAEANKNINGTGGIGSFHNFHCTNIHSNTLDSRFYC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTT4</accession>
    <name>Q5CTT4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit</fullName>
            <shortName evidence="8">Oligosaccharyl transferase 48 kDa subunit</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd2_1650</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 8">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the oligosaccharyltransferase (OST) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endoplasmic reticulum membrane</location>
            <topology evidence="8">Single-pass type I membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the DDOST 48 kDa subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626385.1">
        <property type="nucleotide sequence ID" value="XM_626385.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTT4"/>
    <dbReference type="SMR" id="Q5CTT4"/>
    <dbReference type="FunCoup" id="Q5CTT4">
        <property type="interactions" value="416"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTT4"/>
    <dbReference type="GeneID" id="3373749"/>
    <dbReference type="KEGG" id="cpv:cgd2_1650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1650"/>
    <dbReference type="InParanoid" id="Q5CTT4"/>
    <dbReference type="OMA" id="AHDEYPR"/>
    <dbReference type="OrthoDB" id="29105at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005013">
        <property type="entry name" value="DDOST_48_kDa_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055459">
        <property type="entry name" value="OST48_MD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055457">
        <property type="entry name" value="OST48_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10830:SF0">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE 48 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23358">
        <property type="entry name" value="OST48_MD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03345">
        <property type="entry name" value="OST48_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005143581" description="Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit" evidence="8">
        <location>
            <begin position="19"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="444"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 N-terminal" evidence="9">
        <location>
            <begin position="40"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="domain" description="OST48 middle" evidence="10">
        <location>
            <begin position="331"/>
            <end position="465"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008743"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU361142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF23358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="468" mass="53573" checksum="E7C379E100857556" modified="2005-04-12" version="1">MLKLFILFIYSFIYLIEAGSGTLGEAPKQIFNADLASLELLILTNSNEKSIKQKYSIFISNLVSAGHEITIKTYNRYSQEQDLELFLYDEFLYNNIIILDIDNSDVHPSFPMSYVPKILNFIDRGGNLMIFVDTIDDTNLNIGENKAIIRLAKECAGIEFLPQNTRLFDVTTDGVGKSSKIFSNNFIESDAIFSPENFTKKGILYHGVGFSNSIPSNELVIPILTACHTCISVNNDIKSKSISLFGNYISSSTGEEIGLVMALQGRNGARATFTSDGKLCSDETIKSNSENSEFCKDIFLWSFQQKGLIKIAEISHRKLNDSFETIVENYDETLNYTVEDIVRFSAEFYKFSNDKWENYDSEDIQLEFTMLDPYIRTYLKQSEEESRRSTFSSTFKIPEVWGVYKFVINHKRIGYNTISYESITTVRNFRHDQNERFNISAMPYYSAFILTIISFCYFTLLFITKSSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTU3</accession>
    <name>Q5CTU3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Cell growth-regulating nucleolar protein, metal binding domain at N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_1540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626376.1">
        <property type="nucleotide sequence ID" value="XM_626376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTU3"/>
    <dbReference type="STRING" id="353152.Q5CTU3"/>
    <dbReference type="GeneID" id="3373718"/>
    <dbReference type="KEGG" id="cpv:cgd2_1540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1540"/>
    <dbReference type="InParanoid" id="Q5CTU3"/>
    <dbReference type="OMA" id="QCITEKE"/>
    <dbReference type="OrthoDB" id="21474at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.490:FF:000001">
        <property type="entry name" value="cell growth-regulating nucleolar protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039999">
        <property type="entry name" value="LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014898">
        <property type="entry name" value="Znf_C2H2_LYAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100:SF10">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13100">
        <property type="entry name" value="CELL GROWTH-REGULATING NUCLEOLAR PROTEIN LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08790">
        <property type="entry name" value="zf-LYAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51804">
        <property type="entry name" value="ZF_C2HC_LYAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger C2H2 LYAR-type" evidence="8">
        <location>
            <begin position="32"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF08790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="151" mass="17463" checksum="AEE8991A05462EF1" modified="2005-04-12" version="1">MVSFVCGNCQDVLKKNKVDSHCVGKCRDAWEFTCIDCNFTFEGFDYKSHNSCITEKEKYCGKLANIKKPVHYPGNSFVDRKKEFQLIIEKILKKNGSMNWKKLVKESIKEYMNSGINDNIEDKILKWECLAAIPISYTTSESNMVSFKQSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU05</accession>
    <name>Q5CU05_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626314.1">
        <property type="nucleotide sequence ID" value="XM_626314.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU05"/>
    <dbReference type="STRING" id="353152.Q5CU05"/>
    <dbReference type="GeneID" id="3373610"/>
    <dbReference type="KEGG" id="cpv:cgd2_800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_800"/>
    <dbReference type="InParanoid" id="Q5CU05"/>
    <dbReference type="OMA" id="SHDIANI"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06174">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="198"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="224"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="286"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="370"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="393"/>
            <end position="419"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="440"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="466"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="506"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="565"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="146"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="604" mass="68021" checksum="E0BC323C83C60FAB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU15</accession>
    <name>Q5CU15_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Large low complexity protein with glycine-rich repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626304.1">
        <property type="nucleotide sequence ID" value="XM_626304.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373381"/>
    <dbReference type="KEGG" id="cpv:cgd2_690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_690"/>
    <dbReference type="InParanoid" id="Q5CU15"/>
    <dbReference type="OMA" id="TYDSKMY"/>
    <dbReference type="OrthoDB" id="9970435at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SPX" evidence="5">
        <location>
            <begin position="17"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="512"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="593"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1262"/>
            <end position="1311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1271"/>
            <end position="1304"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1361" mass="151384" checksum="E1F73413C257E8C9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU18</accession>
    <name>Q5CU18_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_650</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626301.1">
        <property type="nucleotide sequence ID" value="XM_626301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU18"/>
    <dbReference type="GeneID" id="3373383"/>
    <dbReference type="KEGG" id="cpv:cgd2_650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_650"/>
    <dbReference type="InParanoid" id="Q5CU18"/>
    <dbReference type="OrthoDB" id="342281at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005635">
        <property type="term" value="C:nuclear envelope"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043495">
        <property type="term" value="F:protein-membrane adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045119">
        <property type="entry name" value="SUN1-5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911:SF8">
        <property type="entry name" value="KLAROID PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12911">
        <property type="entry name" value="SAD1/UNC-84-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="8">
        <location>
            <begin position="415"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="672"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="297"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="678"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="692" mass="81886" checksum="82D770678F97B033" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU77</accession>
    <name>Q5CU77_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Prolyl 4-hydroxylase alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_3910</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>L-ascorbate</name>
            <dbReference type="ChEBI" id="CHEBI:38290"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626937.1">
        <property type="nucleotide sequence ID" value="XM_626937.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU77"/>
    <dbReference type="STRING" id="353152.Q5CU77"/>
    <dbReference type="GeneID" id="3373862"/>
    <dbReference type="KEGG" id="cpv:cgd3_3910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3910"/>
    <dbReference type="InParanoid" id="Q5CU77"/>
    <dbReference type="OMA" id="MSENCAT"/>
    <dbReference type="OrthoDB" id="407973at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005506">
        <property type="term" value="F:iron ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031418">
        <property type="term" value="F:L-ascorbic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004656">
        <property type="term" value="F:procollagen-proline 4-dioxygenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.620">
        <property type="entry name" value="q2cbj1_9rhob like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045054">
        <property type="entry name" value="P4HA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006620">
        <property type="entry name" value="Pro_4_hyd_alph"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869">
        <property type="entry name" value="PROLYL 4-HYDROXYLASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10869:SF246">
        <property type="entry name" value="TRANSMEMBRANE PROLYL 4-HYDROXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00702">
        <property type="entry name" value="P4Hc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0223">Dioxygenase</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Prolyl 4-hydroxylase alpha subunit" evidence="7">
        <location>
            <begin position="457"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="53"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="221"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="491"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="642"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="689"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="53"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="491"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="642"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022964"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="717" mass="76483" checksum="87264068E0D86184" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU97</accession>
    <name>Q5CU97_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="4">3.4.19.12</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Deubiquitinating enzyme MINDY-3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_3680</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2">Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the MINDY deubiquitinase family. FAM188 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89249.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626917.1">
        <property type="nucleotide sequence ID" value="XM_626917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU97"/>
    <dbReference type="FunCoup" id="Q5CU97">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU97"/>
    <dbReference type="GeneID" id="3373934"/>
    <dbReference type="KEGG" id="cpv:cgd3_3680"/>
    <dbReference type="InParanoid" id="Q5CU97"/>
    <dbReference type="OMA" id="INYSESM"/>
    <dbReference type="OrthoDB" id="10263628at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990380">
        <property type="term" value="F:K48-linked deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071108">
        <property type="term" value="P:protein K48-linked deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025257">
        <property type="entry name" value="MINDY-3/4_CD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039785">
        <property type="entry name" value="MINY3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003903">
        <property type="entry name" value="UIM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12473:SF8">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE MINDY-4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13898">
        <property type="entry name" value="MINDY-3_4_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01174">
        <property type="entry name" value="DUF4205"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50330">
        <property type="entry name" value="UIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="EF-hand" evidence="7">
        <location>
            <begin position="493"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00002107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00033208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89249.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="661" mass="76510" checksum="1448DD25FE5FADFC" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUE8</accession>
    <name>Q5CUE8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">AOX1,alternative oxidase, possible fungal or bacterial origin, 2 transmembrane regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd3_3120</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="12">
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
        </cofactor>
        <text evidence="12">Binds 2 iron ions per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the alternative oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89022.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626866.1">
        <property type="nucleotide sequence ID" value="XM_626866.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUE8"/>
    <dbReference type="SMR" id="Q5CUE8"/>
    <dbReference type="STRING" id="353152.Q5CUE8"/>
    <dbReference type="GeneID" id="3373882"/>
    <dbReference type="KEGG" id="cpv:cgd3_3120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3120"/>
    <dbReference type="InParanoid" id="Q5CUE8"/>
    <dbReference type="OMA" id="VHTYTRA"/>
    <dbReference type="OrthoDB" id="16906at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009916">
        <property type="term" value="F:alternative oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010230">
        <property type="term" value="P:alternative respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01053">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1260.140">
        <property type="entry name" value="Alternative oxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002680">
        <property type="entry name" value="AOX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038659">
        <property type="entry name" value="AOX_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31803:SF3">
        <property type="entry name" value="ALTERNATIVE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01786">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005229">
        <property type="entry name" value="AOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0249">Electron transport</keyword>
    <keyword evidence="10 12" id="KW-0408">Iron</keyword>
    <keyword evidence="11 13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0679">Respiratory chain</keyword>
    <keyword evidence="5 13 14" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 13" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="165"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="212"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="215"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="264"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="317"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Fe cation</name>
            <dbReference type="ChEBI" id="CHEBI:24875"/>
            <label>2</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022660"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR005229-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK89022.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="335" mass="39120" checksum="6FEBBDCAE28C0055" modified="2007-04-03" version="1">MYYVRNLSNTNKLRYFYGRHLWLLSSKVNLNNLCSIVHSNKGQKITSKLYITLEKDRSSNNQGDFSKKRTLECKSDQINKFDAENEEKVGSHFMKKSNHAASILEGKEYGFNSPIWDLEEVNNVQKTHLCPNGFKDKMSYYLVIALRKSFDLLTRYKKGHNEYQWCRRIIFLETVAGVPGMVGAMLRHFSSLRKMKRDNGWIHTLLEEAENERMHLLISLQLINKPSILTRVSVIGTQFAFLIFYTVFYIISPKYSHRFVGYLEEEAVSTYTHLIEEIDKGLLPGFERKAPKFASVYYGLPEDATIRDLFLAMRRDESHHRDVNHNLADIRLNGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUG2</accession>
    <name>Q5CUG2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">KRR1 small subunit processome component</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">KRR-R motif-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd3_2950</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Component of the ribosomal small subunit (SSU) processome.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the KRR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89036.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626852.1">
        <property type="nucleotide sequence ID" value="XM_626852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUG2"/>
    <dbReference type="FunCoup" id="Q5CUG2">
        <property type="interactions" value="434"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUG2"/>
    <dbReference type="GeneID" id="3374100"/>
    <dbReference type="KEGG" id="cpv:cgd3_2950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2950"/>
    <dbReference type="InParanoid" id="Q5CUG2"/>
    <dbReference type="OMA" id="TPDIDKW"/>
    <dbReference type="OrthoDB" id="441223at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22393">
        <property type="entry name" value="KH-I_KRR1_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd22394">
        <property type="entry name" value="KH-I_KRR1_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1370.10:FF:000014">
        <property type="entry name" value="KRR1 small subunit processome component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041174">
        <property type="entry name" value="KRR1-like_KH1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048550">
        <property type="entry name" value="KRR1-like_KH1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048548">
        <property type="entry name" value="KRR1-like_KH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048549">
        <property type="entry name" value="KRR1-like_KH2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024166">
        <property type="entry name" value="rRNA_assembly_KRR1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581">
        <property type="entry name" value="HIV-1 REV BINDING PROTEIN 2, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12581:SF0">
        <property type="entry name" value="KRR1 SMALL SUBUNIT PROCESSOME COMPONENT HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17903">
        <property type="entry name" value="KH_KRR1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21800">
        <property type="entry name" value="KH_KRR1_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006515">
        <property type="entry name" value="KRR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="5 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 8" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="K Homology" evidence="10">
        <location>
            <begin position="142"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="286"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR006515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89036.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="358" mass="42407" checksum="7DB80FAA4DEC8CBA" modified="2005-04-12" version="1">MLEMSVGTPMENQEIISKKRRYRKDKPWDTDDIDHWNVPKLTPEDNPHGLLEESSFAVLFPKYREKYLRDIWPDIRNALKAHHIKCELDLVEGSITVRTTGKTWDPFIIIRARDMVKLLSRSVPFHQAVRILGEGEDDNNLGCDIIKIGHRNKEKMVKRRQRLVGPNGSTLKAIELLTNCYVLVQGQTVSVIGSYKSLKLVRRIVEDCMNNIHPVYHIKELMIKRELEKDERLRGENWDRFLPKFKNKCVKRKVKKQIKKKNKSIFPPEPTPRKEDMLLETGEYFYSELERKAKQIKERISEQKEKKNEKHMEREKMYIPPNEKLFLKNKTSNQNEINYKTFGQNSEKYKNNLSNFVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUP2</accession>
    <name>Q5CUP2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative choline kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2010-03" db="PDB data bank">
            <title>Crystal structure of choline kinase from Cryptosporidium parvum Iowa II, cgd3_2030.</title>
            <authorList>
                <person name="Qiu W."/>
                <person name="Wernimont A."/>
                <person name="Hills T."/>
                <person name="Lew J."/>
                <person name="Artz J.D."/>
                <person name="Xiao T."/>
                <person name="Allali-Hassani A."/>
                <person name="Vedadi M."/>
                <person name="Kozieradzki I."/>
                <person name="Cossar D."/>
                <person name="Bountra C."/>
                <person name="Weigelt J."/>
                <person name="Arrowsmith C.H."/>
                <person name="Edwards A.M."/>
                <person name="Hui R."/>
                <person name="Ma D."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) IN COMPLEX WITH ADP AND MG(2+)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the choline/ethanolamine kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626772.1">
        <property type="nucleotide sequence ID" value="XM_626772.1"/>
    </dbReference>
    <dbReference type="PDB" id="3MES">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.35 A"/>
        <property type="chains" value="A/B=1-405"/>
    </dbReference>
    <dbReference type="PDBsum" id="3MES"/>
    <dbReference type="AlphaFoldDB" id="Q5CUP2"/>
    <dbReference type="SMR" id="Q5CUP2"/>
    <dbReference type="FunCoup" id="Q5CUP2">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUP2"/>
    <dbReference type="GeneID" id="3373788"/>
    <dbReference type="KEGG" id="cpv:cgd3_2030"/>
    <dbReference type="InParanoid" id="Q5CUP2"/>
    <dbReference type="OMA" id="PLSCHEI"/>
    <dbReference type="OrthoDB" id="3649325at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CUP2"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004103">
        <property type="term" value="F:choline kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004305">
        <property type="term" value="F:ethanolamine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006646">
        <property type="term" value="P:phosphatidylethanolamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14021">
        <property type="entry name" value="ChoK-like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1200.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603">
        <property type="entry name" value="CHOLINE/ETHANOALAMINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22603:SF93">
        <property type="entry name" value="RE24176P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01633">
        <property type="entry name" value="Choline_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="4">
        <location>
            <position position="63"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="64"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="65"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="89"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="130"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="131"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="285"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="288"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="3MES"/>
        </source>
    </evidence>
    <sequence length="405" mass="47537" checksum="A9671F3D7D420183" modified="2005-04-12" version="1" fragment="single">KKKKEMPFPNKKIELGDKLSESIRSFSTITDTEIIIGICRKNIPGWKEINESYIEVKQIFSGLTNQLFVVSIVNESMSLSLKHPRILFRIYGKHVGKFYDSKVELDVFRYLSNINIAPNIIADFPEGRIEEFIDGEPLTTKQLQLTHICVEVAKNMGSLHIINSKRADFPSRFDKEPILFKRIYLWREEAKIQVSKNNFQIDKELYSKILEEIDQLEELIMGGEKFSMERALELKLYSPAFSLVFAHNDLQENNLLQTQNNIRMIDYEYSAINFAGADIANYFCEYIYDYCSEKQPYFKFKYEDYPCEELRKLFISVYLSQTLQEQVMPSQQIVHIMTKAVEVFTLISHITWGLWSIARTPGYQPNSVEFDFTEYANTRFTHYLQKKKELIDQGILPLNSWLFNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUR0</accession>
    <name>Q5CUR0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626754.1">
        <property type="nucleotide sequence ID" value="XM_626754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUR0"/>
    <dbReference type="GeneID" id="3374156"/>
    <dbReference type="KEGG" id="cpv:cgd3_1830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1830"/>
    <dbReference type="InParanoid" id="Q5CUR0"/>
    <dbReference type="OMA" id="DIEISKC"/>
    <dbReference type="OrthoDB" id="340966at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254251" evidence="1">
        <location>
            <begin position="31"/>
            <end position="1099"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1099" mass="125346" checksum="F51B333F72E444BE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUS6</accession>
    <name>Q5CUS6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">protein-synthesizing GTPase</fullName>
            <ecNumber evidence="2">3.6.5.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_1650</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>GTP + H2O = GDP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19669"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="EC" id="3.6.5.3"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.3" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626738.1">
        <property type="nucleotide sequence ID" value="XM_626738.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUS6"/>
    <dbReference type="FunCoup" id="Q5CUS6">
        <property type="interactions" value="324"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUS6"/>
    <dbReference type="GeneID" id="3374004"/>
    <dbReference type="KEGG" id="cpv:cgd3_1650"/>
    <dbReference type="InParanoid" id="Q5CUS6"/>
    <dbReference type="OMA" id="NIGMVGH"/>
    <dbReference type="OrthoDB" id="1045173at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01888">
        <property type="entry name" value="eIF2_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03688">
        <property type="entry name" value="eIF2_gamma_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15490">
        <property type="entry name" value="eIF2_gamma_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000009">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000065">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.30.10:FF:000075">
        <property type="entry name" value="Translation initiation factor 2 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004161">
        <property type="entry name" value="EFTu-like_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050543">
        <property type="entry name" value="eIF2G"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015256">
        <property type="entry name" value="eIF2g_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044127">
        <property type="entry name" value="eIF2g_dom_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044128">
        <property type="entry name" value="eIF2g_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009001">
        <property type="entry name" value="Transl_elong_EF1A/Init_IF2_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003077">
        <property type="entry name" value="PRK04000.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42854:SF3">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09173">
        <property type="entry name" value="eIF2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03144">
        <property type="entry name" value="GTP_EFTU_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50465">
        <property type="entry name" value="EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="9">
        <location>
            <begin position="41"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007249"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="474" mass="52148" checksum="5BC1AB5EE09671DE" modified="2005-04-12" version="1" fragment="single">KKLFVDIEFIKMSSDHLSKQDADNLDLTKLTPITPEVISRQATINLGTIGHVAHGKSTVVRAVSGVQTVRFKDEKERNITIKLGYANAKIYKCTNPNCPPPKCYRSYGSNKEDEPMCEVPSCNHKMQLLRHVSFVDCPGHDILMSTMLNGAAVMDAALLLVAGNETCPQPQTSEHLAAVEIMKLKHIIILQNKVELIKEAQAQEQYKQIKDFVAGTSAQDAPIIPISAVLKFNIDVLCEYICTQIPIPIRDFTSSPRMIIIRSFDVNKPGEDAQNMRGGVAGGSIIKGVLKIGDEIEVRPGIYNKDADGEFTCRPIRSKIVSLFAEHNDLKYAVSGGLIGVGTKIDPTLTRANRLSGQVLGHPGFLPEIYDSINITLYRMRRLLGVRAHDGSKAQAKVSKLREGELLMVNIGSTTTGGRVTKIRDDLATFQLSSPVCCSVGDKLAISRRVDKHWRLIGFGDIISGDTVRIINDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUZ4</accession>
    <name>Q5CUZ4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase</fullName>
            <ecNumber evidence="7">2.1.1.205</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>cytidine(32)/guanosine(34) in tRNA + 2 S-adenosyl-L-methionine = 2'-O-methylcytidine(32)/2'-O-methylguanosine(34) in tRNA + 2 S-adenosyl-L-homocysteine + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:42396"/>
            <dbReference type="Rhea" id="RHEA-COMP:10246"/>
            <dbReference type="Rhea" id="RHEA-COMP:10247"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:74445"/>
            <dbReference type="ChEBI" id="CHEBI:74495"/>
            <dbReference type="ChEBI" id="CHEBI:82748"/>
            <dbReference type="EC" id="2.1.1.205"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.205" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626670.1">
        <property type="nucleotide sequence ID" value="XM_626670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUZ4"/>
    <dbReference type="FunCoup" id="Q5CUZ4">
        <property type="interactions" value="521"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUZ4"/>
    <dbReference type="GeneID" id="3373809"/>
    <dbReference type="KEGG" id="cpv:cgd3_890"/>
    <dbReference type="InParanoid" id="Q5CUZ4"/>
    <dbReference type="OMA" id="YDDMIND"/>
    <dbReference type="OrthoDB" id="289250at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106340">
        <property type="term" value="F:tRNA (guanosine(34)-2'-O)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000220">
        <property type="entry name" value="CAMK protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03162">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028590">
        <property type="entry name" value="RNA_methyltr_E_TRM7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF12">
        <property type="entry name" value="TRNA (CYTIDINE(32)_GUANOSINE(34)-2'-O)-METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 10" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="6" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="9">
        <location>
            <begin position="42"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00035677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="296" mass="33743" checksum="FB37F4A0972D18C5" modified="2005-04-12" version="1" fragment="single">IDLQNKKKILNLKIYNSIVLQMGKLSRDRRDIYYRRAKQEGFRARSAYKLIQIDEKYNIFDKVTRAVDLCAAPGSWSQVLSTKLLNNSEYNEGQPKETDQIDSNNGEAPLIVAVDLQEMAPIYGVNIIKGDITSQLTVSRILEYFQGKKADLVLCDGSPDVTGLHDIDEYIQNQLLVSSLSITSKIMRKGGTFVAKIFRGENISRIYQQMFCYFELVDCCKPESSRNSSLEAFIVCRYFKFDDQDSTNVNFEIPDPLTVPFISCGDLSEYDPDKTYETEYTSSLEPIQPPINAPYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV10</accession>
    <name>Q5CV10_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_710</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626654.1">
        <property type="nucleotide sequence ID" value="XM_626654.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3374139"/>
    <dbReference type="KEGG" id="cpv:cgd3_710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_710"/>
    <dbReference type="InParanoid" id="Q5CV10"/>
    <dbReference type="OMA" id="FRERAYG"/>
    <dbReference type="OrthoDB" id="342926at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1181"/>
            <end position="1214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1015"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1199"/>
            <end position="1212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1320" mass="151683" checksum="91ED82CDC35A3206" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVG4</accession>
    <name>Q5CVG4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM+RGG RNA binding repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_4150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627305.1">
        <property type="nucleotide sequence ID" value="XM_627305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVG4"/>
    <dbReference type="STRING" id="353152.Q5CVG4"/>
    <dbReference type="GeneID" id="3374627"/>
    <dbReference type="KEGG" id="cpv:cgd8_4150"/>
    <dbReference type="InParanoid" id="Q5CVG4"/>
    <dbReference type="OMA" id="HMENELC"/>
    <dbReference type="OrthoDB" id="48651at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="130"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="39"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="211"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="46"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="81"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="219"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="258"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="290"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="327"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="389"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="417"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="440"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="451"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="468"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="507" mass="54709" checksum="62583D45D3F32990" modified="2005-04-12" version="1" fragment="single">FQLSLHRFYINKTNHMENELCRSRTTRWADVEAEEDDLDMSLPIERTNQTSTTSVSDVNTALSSSNMNNSNDKADSKKKFNINNNQSSSYNNNNNNNNNNNSNNNGSNNNNSGTARQNKKVVNLPREAPFIAKVTNLDYSLQLKDIQDFFKNNKIEDVKIKLPMRNGNNEGVAIVEFENFDDLSNSVNNLDGLCIGSRNIRVNAVIQKNKMDDNKTIHRGNNNISRNGGNHSNNNSSYSSGNSQSNSGQSNFISNNNRGNKSHNMSNRDSSPDFTIVRRMNPTKSDESNPKNQSSANSSSSNNTSSSGSKPTSSAQKDYFSDKSKSASKSRSNNSSDQPHSSSNTHSETSNNSTNKNTVTSYESERSGGASGNRRWNFGASKEKGRYKQSGNESSQFRTVKGSSGGGRGNESMGRDFVGGGGISRGGGNRDGSDSKRGGRGYQGSGGEGVGNNHSNASRGAGSGSNNGGVSESRVSSGSKGKVFSHKGGSNNASIETRNRFAALDES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVH6</accession>
    <name>Q5CVH6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627293.1">
        <property type="nucleotide sequence ID" value="XM_627293.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVH6"/>
    <dbReference type="GeneID" id="3374596"/>
    <dbReference type="KEGG" id="cpv:cgd8_4020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4020"/>
    <dbReference type="InParanoid" id="Q5CVH6"/>
    <dbReference type="OrthoDB" id="340641at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="202"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="416"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="540"/>
            <end position="596"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="783" mass="89400" checksum="3BD65A7CA0BAF8A7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVR6</accession>
    <name>Q5CVR6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_3050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627203.1">
        <property type="nucleotide sequence ID" value="XM_627203.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVR6"/>
    <dbReference type="GeneID" id="3374236"/>
    <dbReference type="KEGG" id="cpv:cgd8_3050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3050"/>
    <dbReference type="InParanoid" id="Q5CVR6"/>
    <dbReference type="OMA" id="LNMINAT"/>
    <dbReference type="OrthoDB" id="337792at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="404" mass="45206" checksum="CF1706FD811F1093" modified="2005-04-12" version="1">MSNLNNLALQLVQILNQHSSDGGPQSAVSSNQTDTANKFLLEHYNNFFLPYISRTGNEHILSNPCNQNSTPIDQLLTSYPNNTGTPIGSILNYDQCGNLKSPSQSTDQEQLNSKQNLDPLTYNSAVKSTQLLLTLQNQTPLIGLQNTPIEVSRPQVSSSSTQQVAPLNILNNNLNNWAESALSTLLDKPDMLMNLMRLGAASIMASYYGQTQNPTGVNILQQSSPFIYNMSLSPKQAETPCINNVSPIEMNNSSMAFTPVKSPSTEKIEHQTPVFTPNASQQFSDELVFYNFLEQSRKLSCDIKNQNEKKNLSTNKSNGQPIRKSCAGRPRLDRSDWCCSLCRCIETAQWRYLRNTLENNQNNICHRGKILVCNACYLRVSKENKIRQKINTYKLEGNIKIDDT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="115" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVW7</accession>
    <name>Q5CVW7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Mtr4p like SKI family SFII helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd8_2520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627152.1">
        <property type="nucleotide sequence ID" value="XM_627152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVW7"/>
    <dbReference type="FunCoup" id="Q5CVW7">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVW7"/>
    <dbReference type="GeneID" id="3374277"/>
    <dbReference type="KEGG" id="cpv:cgd8_2520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2520"/>
    <dbReference type="InParanoid" id="Q5CVW7"/>
    <dbReference type="OMA" id="CIYQISA"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006401">
        <property type="term" value="P:RNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000083">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000141">
        <property type="entry name" value="ATP-dependent RNA helicase DOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.300">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025696">
        <property type="entry name" value="Beta-barrel_MTR4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016438">
        <property type="entry name" value="SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF7">
        <property type="entry name" value="EXOSOME RNA HELICASE MTR4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13234">
        <property type="entry name" value="MTR4_beta-barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005198">
        <property type="entry name" value="Antiviral_helicase_SKI2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="108"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="337"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="590"/>
            <end position="615"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1280" mass="146500" checksum="5F95C92020599DBD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVZ9</accession>
    <name>Q5CVZ9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_2170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627120.1">
        <property type="nucleotide sequence ID" value="XM_627120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVZ9"/>
    <dbReference type="FunCoup" id="Q5CVZ9">
        <property type="interactions" value="187"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVZ9"/>
    <dbReference type="GeneID" id="3374559"/>
    <dbReference type="KEGG" id="cpv:cgd8_2170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2170"/>
    <dbReference type="InParanoid" id="Q5CVZ9"/>
    <dbReference type="OMA" id="CALESQH"/>
    <dbReference type="OrthoDB" id="193243at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000008">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="15"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="11">
        <location>
            <begin position="98"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="137" mass="14590" checksum="31CF540C0622A1ED" modified="2005-04-12" version="1">MSGKVTSSGGRGGGKKTTRKTMSNSAKAGLQFPVGRVARYLKKGRYAKRIGAAAPVYLAAVLEYLCAELLELAGNAARDAKKTRITPRQIQLAVRNDEELSKFLGNVTIASGGVLPNIPTVLLPKKSKSKQGNSQEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW33</accession>
    <name>Q5CW33_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_1800</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627086.1">
        <property type="nucleotide sequence ID" value="XM_627086.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW33"/>
    <dbReference type="SMR" id="Q5CW33"/>
    <dbReference type="GeneID" id="3374504"/>
    <dbReference type="KEGG" id="cpv:cgd8_1800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1800"/>
    <dbReference type="InParanoid" id="Q5CW33"/>
    <dbReference type="OMA" id="NACPTIN"/>
    <dbReference type="OrthoDB" id="343325at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255018" evidence="3">
        <location>
            <begin position="22"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="255"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="148"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="272"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="307"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="365"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="365" mass="40856" checksum="12A37B02B1E74FC1" modified="2005-04-12" version="1">MNFRLVSVLVALFAVVQFAVSTSVIGLLEGFSKYFYSLSYERKQNIVHEAVQELQSVFPQGMETISLPESVDLDTCKATLQKAVQQNHEWYLLAMGQFTQLKFYNSFLNEKVSGDLKEAIEKASMSSNSQGSSDSIVVNGVLYNTQQLSQVLADAQALREENVQLRNALSSVREDLEKSATTIEELKLEAQSSLQEAIRAKADINKFEKRLSVCRRNEYNLKKIIYENKRGRFSRFKSAISKPFRAHKLKKALGKEGYKAHKQKKQADSKKRKEMVKKIKKEMRQSKSDKRKKLLNKSIAPGEDTPIPSSVESSLQTEQSLGKGETSTSNPLENSVSSVASFSTTENSKSEKGDSSMGSIFEGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWB6</accession>
    <name>Q5CWB6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Clathrin coat assembly protein AP50</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_950</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627003.1">
        <property type="nucleotide sequence ID" value="XM_627003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWB6"/>
    <dbReference type="FunCoup" id="Q5CWB6">
        <property type="interactions" value="157"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWB6"/>
    <dbReference type="GeneID" id="3374633"/>
    <dbReference type="KEGG" id="cpv:cgd8_950"/>
    <dbReference type="InParanoid" id="Q5CWB6"/>
    <dbReference type="OMA" id="DYGYIQN"/>
    <dbReference type="OrthoDB" id="10259133at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030131">
        <property type="term" value="C:clathrin adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09253">
        <property type="entry name" value="AP-4_Mu4_Cterm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14838">
        <property type="entry name" value="AP4_Mu_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.450.60:FF:000002">
        <property type="entry name" value="AP-2 complex subunit mu, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1170">
        <property type="entry name" value="Mu homology domain, subdomain B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050431">
        <property type="entry name" value="Adaptor_comp_med_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036168">
        <property type="entry name" value="AP2_Mu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001392">
        <property type="entry name" value="Clathrin_mu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028565">
        <property type="entry name" value="MHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10529">
        <property type="entry name" value="AP COMPLEX SUBUNIT MU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00928">
        <property type="entry name" value="Adap_comp_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005992">
        <property type="entry name" value="Clathrin_mu"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00314">
        <property type="entry name" value="CLATHRINADPT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49447">
        <property type="entry name" value="Second domain of Mu2 adaptin subunit (ap50) of ap2 adaptor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51072">
        <property type="entry name" value="MHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="MHD" evidence="5">
        <location>
            <begin position="268"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="548" mass="62911" checksum="7B09A18692F9A33F" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWB7</accession>
    <name>Q5CWB7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89320.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627002.1">
        <property type="nucleotide sequence ID" value="XM_627002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWB7"/>
    <dbReference type="GeneID" id="3374421"/>
    <dbReference type="KEGG" id="cpv:cgd8_940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_940"/>
    <dbReference type="InParanoid" id="Q5CWB7"/>
    <dbReference type="OMA" id="KMIDDMH"/>
    <dbReference type="OrthoDB" id="439961at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89320.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="174" mass="19799" checksum="64EBE2F3196DE035" modified="2005-04-12" version="1">MAKGLRSKVKRRFRTAKRLLIKNTLELSRNTEKSNALREIGEGTYVQKEIPLNAFLYPESKNAIFPQKNRNASIDFRSESISSIAGYMGPGNRRKYYPGEEIPILSIMGDGNMTNSRDVEIINTTNMNMNIDSTNQVKDVVEFETEKRQVSIPVIKDSIKGAYEASFKKKSKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWB8</accession>
    <name>Q5CWB8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">RBX1 ortholog, RING finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_930</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627001.1">
        <property type="nucleotide sequence ID" value="XM_627001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWB8"/>
    <dbReference type="FunCoup" id="Q5CWB8">
        <property type="interactions" value="431"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWB8"/>
    <dbReference type="GeneID" id="3374420"/>
    <dbReference type="KEGG" id="cpv:cgd8_930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_930"/>
    <dbReference type="InParanoid" id="Q5CWB8"/>
    <dbReference type="OMA" id="NACPLDN"/>
    <dbReference type="OrthoDB" id="8962942at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16485">
        <property type="entry name" value="mRING-H2-C3H2C2D_RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000010">
        <property type="entry name" value="E3 ubiquitin-protein ligase RBX1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051031">
        <property type="entry name" value="RING-box_E3_Ubiquitin_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024766">
        <property type="entry name" value="Znf_RING_H2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11210">
        <property type="entry name" value="RING BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12678">
        <property type="entry name" value="zf-rbx1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="57"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="124" mass="14444" checksum="A36EC606823AE2F2" modified="2005-04-12" version="1">MDTRSCEQVNEEMIDQKIEENNTANNSVNTEPGQKRFEIKKWNAVALWSWDIVVDNCAICRNHIMDLCIECQANTGSAQRSEECTVTWGQCNHAFHLHCISRWLKTRNVCPLDNTEWVFQKQGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWI9</accession>
    <name>Q5CWI9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Transporter protein with conserved Zn ribbon C11C7CxxC</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_4890</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CRT-like transporter family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90068.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627815.1">
        <property type="nucleotide sequence ID" value="XM_627815.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWI9"/>
    <dbReference type="STRING" id="353152.Q5CWI9"/>
    <dbReference type="GeneID" id="3375813"/>
    <dbReference type="KEGG" id="cpv:cgd6_4890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4890"/>
    <dbReference type="InParanoid" id="Q5CWI9"/>
    <dbReference type="OMA" id="FAYIIPM"/>
    <dbReference type="OrthoDB" id="416555at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042910">
        <property type="term" value="F:xenobiotic transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006865">
        <property type="term" value="P:amino acid transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013936">
        <property type="entry name" value="CRT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017258">
        <property type="entry name" value="Transprt_Chloroquine"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31326">
        <property type="entry name" value="PROTEIN CLT2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31326:SF1">
        <property type="entry name" value="PROTEIN CLT2, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08627">
        <property type="entry name" value="CRT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037671">
        <property type="entry name" value="Transprt_Chloroquine_res"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="44"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="138"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="169"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="236"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="311"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="370"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90068.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="446" mass="49699" checksum="43FECA38BD6C2344" modified="2007-04-03" version="1">MNGSGRELLLGSESENEQIQIITLIKNGMSALNEGVIKPCKENFFLIVCMMSLLISSVFNSVFFKKMTSAMPNHVWFLTQLTSALYIPLFGLVLLISYFRGELSRDNLEFPMSKFWMMGFFDAFSSILTLLASTHTSGVMQVVLGQMCTPITLVMLSSICKDRFHKLQYIGATVMVMGIFIVKSTLILGIRKSSGAENSNQLIFNILFVIACIPASASSVYKDLSFREYSSLNENYLQFCVAATQVIIGFILVPINSLSILGPQKIEMNQIPSLLFDGANCLFLKRNSITESCGGELQRPCDNCNSAQFPVLIYFIANVICNVFSVLVLKHGTASTGFIVSTLRLPVTTLVFFSPRLVGKEATEPKVEDLIGILILILGLILYRLGSVKINQEEEEIQTEEEPERDYYELSSMTYSKETIDKIKSNTSSTTCSFNIEYDSSHFHSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWS4</accession>
    <name>Q5CWS4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_3930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627730.1">
        <property type="nucleotide sequence ID" value="XM_627730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWS4"/>
    <dbReference type="STRING" id="353152.Q5CWS4"/>
    <dbReference type="GeneID" id="3375904"/>
    <dbReference type="KEGG" id="cpv:cgd6_3930"/>
    <dbReference type="InParanoid" id="Q5CWS4"/>
    <dbReference type="OMA" id="QLMEQDF"/>
    <dbReference type="OrthoDB" id="344359at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037">
        <property type="entry name" value="FORMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13037:SF24">
        <property type="entry name" value="POLYCOMB PROTEIN PCL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0945">Host-virus interaction</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="22"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="265"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="30"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="69"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="157"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="215"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="381"/>
            <end position="391"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="421"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="435"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="455"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="508"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="607"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="708"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="737"/>
            <end position="774"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="775"/>
            <end position="784"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022581"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="844" mass="91591" checksum="C4E0661ABBB0CF4D" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWT3</accession>
    <name>Q5CWT3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Membrane bound aspartyl proteinase with a signal peptide plus transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_3820</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 7">Belongs to the peptidase A1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627721.1">
        <property type="nucleotide sequence ID" value="XM_627721.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWT3"/>
    <dbReference type="SMR" id="Q5CWT3"/>
    <dbReference type="STRING" id="353152.Q5CWT3"/>
    <dbReference type="MEROPS" id="A01.058"/>
    <dbReference type="GeneID" id="3375737"/>
    <dbReference type="KEGG" id="cpv:cgd6_3820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3820"/>
    <dbReference type="InParanoid" id="Q5CWT3"/>
    <dbReference type="OMA" id="DMQYYGE"/>
    <dbReference type="OrthoDB" id="771136at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.70.10:FF:000115">
        <property type="entry name" value="Lysosomal aspartic protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001461">
        <property type="entry name" value="Aspartic_peptidase_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001969">
        <property type="entry name" value="Aspartic_peptidase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033121">
        <property type="entry name" value="PEPTIDASE_A1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47966:SF51">
        <property type="entry name" value="BETA-SITE APP-CLEAVING ENZYME, ISOFORM A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00026">
        <property type="entry name" value="Asp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00792">
        <property type="entry name" value="PEPSIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00141">
        <property type="entry name" value="ASP_PROTEASE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51767">
        <property type="entry name" value="PEPTIDASE_A1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="6" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="2 7" id="KW-0645">Protease</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="8 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255035" evidence="9">
        <location>
            <begin position="21"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="447"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase A1" evidence="10">
        <location>
            <begin position="96"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="114"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="305"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="6">
        <location>
            <begin position="127"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR601461-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="467" mass="52406" checksum="0323BF197582A328" modified="2007-04-03" version="1">MVFQVFFILMMLKISAFCEGLSNKIRSNARAELGMEAILSNGLFNSNAQKVELKLSLSEGGMKYSEGNYFSRWITKSKYSETMDSQDLRNYQNSQYFGKIEVGTPPREFVVIFDTGSSSVWIPSIECKHKGCEPHNKYDPKLSTSYQKLGDGSLETYIQYGTGSCVLKFGKEVINIGKLKIEDQSFGMAIEESTSPFAELPFDGLVGLGFPDKNSKKNNIPTIVENIKERNILPRNLFGVYISRDSSTPGSISFGAADPKYTISGQKITWHRLTGSHYWEIKIKDIKINGVSTNYCFGDCKAAIDTGSSVSTAPSSFMRKITKVIPMEGECNRYLSSPRITYVIEDIHGNEIEMHMDPQDYVIDEGGPSSFNAFSYYWGPQEHYCSIGYIPLDIPAPRGPLFVLGNNFIRKYYSIFDRDNLMVGFTLAKHSKYGPMFISLSSNSESVLKMATFGITIILSLLLFIIY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWT6</accession>
    <name>Q5CWT6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Glyceraldehyde-3-phosphate dehydrogenase</fullName>
            <ecNumber evidence="10">1.2.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_3790</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2008-04" db="PDB data bank">
            <title>Crystal structure of Cryptosporidium parvum glyceraldehyde-3-phosphate dehydrogenase.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Lew J."/>
                <person name="Kozieradzki I."/>
                <person name="Cossar D."/>
                <person name="Schapiro M."/>
                <person name="Bochkarev A."/>
                <person name="Bountra C."/>
                <person name="Weigelt J."/>
                <person name="Edwards A.M."/>
                <person name="Hui R."/>
                <person name="Pizarro J."/>
                <person name="Hills T."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 4-339 IN COMPLEX WITH NAD(+)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>D-glyceraldehyde 3-phosphate + phosphate + NAD(+) = (2R)-3-phospho-glyceroyl phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10300"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="1.2.1.12"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 1/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2 10">Homotetramer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.2.1.12" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627718.1">
        <property type="nucleotide sequence ID" value="XM_627718.1"/>
    </dbReference>
    <dbReference type="PDB" id="3CPS">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B=4-339"/>
    </dbReference>
    <dbReference type="PDBsum" id="3CPS"/>
    <dbReference type="AlphaFoldDB" id="Q5CWT6"/>
    <dbReference type="SMR" id="Q5CWT6"/>
    <dbReference type="FunCoup" id="Q5CWT6">
        <property type="interactions" value="33"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWT6"/>
    <dbReference type="GeneID" id="3375734"/>
    <dbReference type="KEGG" id="cpv:cgd6_3790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3790"/>
    <dbReference type="InParanoid" id="Q5CWT6"/>
    <dbReference type="OMA" id="YGYTCNM"/>
    <dbReference type="OrthoDB" id="1152826at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00184"/>
    </dbReference>
    <dbReference type="EvolutionaryTrace" id="Q5CWT6"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004365">
        <property type="term" value="F:glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051287">
        <property type="term" value="F:NAD binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006006">
        <property type="term" value="P:glucose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd18126">
        <property type="entry name" value="GAPDH_I_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05214">
        <property type="entry name" value="GAPDH_I_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.360.10:FF:000001">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000474">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.360.10">
        <property type="entry name" value="Dihydrodipicolinate Reductase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020831">
        <property type="entry name" value="GlycerAld/Erythrose_P_DH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020830">
        <property type="entry name" value="GlycerAld_3-P_DH_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020829">
        <property type="entry name" value="GlycerAld_3-P_DH_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020828">
        <property type="entry name" value="GlycerAld_3-P_DH_NAD(P)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006424">
        <property type="entry name" value="Glyceraldehyde-3-P_DH_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01534">
        <property type="entry name" value="GAPDH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836">
        <property type="entry name" value="GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10836:SF76">
        <property type="entry name" value="GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02800">
        <property type="entry name" value="Gp_dh_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00044">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000149">
        <property type="entry name" value="GAP_DH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00078">
        <property type="entry name" value="G3PDHDRGNASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00846">
        <property type="entry name" value="Gp_dh_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55347">
        <property type="entry name" value="Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00071">
        <property type="entry name" value="GAPDH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="4 7 10" id="KW-0520">NAD</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3 10" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glyceraldehyde 3-phosphate dehydrogenase NAD(P) binding" evidence="11">
        <location>
            <begin position="3"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="153"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="12"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="12"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="13"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 14">
        <location>
            <position position="34"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 14">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="152"/>
            <end position="154"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="183"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="214"/>
            <end position="215"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="237"/>
        </location>
        <ligand>
            <name>D-glyceraldehyde 3-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7 14">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </ligand>
    </feature>
    <feature type="site" description="Activates thiol group during catalysis" evidence="8">
        <location>
            <position position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007406"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR000149-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000397"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="3CPS"/>
        </source>
    </evidence>
    <sequence length="339" mass="36126" checksum="015FD24450C68610" modified="2007-04-03" version="1">MTATLGINGFGRIGRLVLRACMERNDITVVAINDPFMDVEYMAYLLKYDSVHGNFNGTVEVSGKDLCINGKVVKVFQAKDPAEIPWGASGAQIVCESTGVFTTEEKASLHLKGGAKKVIISAPPKDNVPMYVMGVNNTEYDPSKFNVISNASCTTNCLAPLAKIINDKFGIVEGLMTTVHSLTANQLTVDGPSKGGKDWRAGRCAGNNIIPASTGAAKAVGKVIPALNGKLTGMAIRVPTPDVSVVDLTCKLAKPASIEEIYQAVKEASNGPMKGIMGYTSDDVVSTDFIGCKYSSIFDKNACIALNDSFVKLISWYDNESGYSNRLVDLAVYVASRGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWU6</accession>
    <name>Q5CWU6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_3670</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89984.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627708.1">
        <property type="nucleotide sequence ID" value="XM_627708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWU6"/>
    <dbReference type="GeneID" id="3375729"/>
    <dbReference type="KEGG" id="cpv:cgd6_3670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3670"/>
    <dbReference type="InParanoid" id="Q5CWU6"/>
    <dbReference type="OMA" id="CNINKSI"/>
    <dbReference type="OrthoDB" id="336832at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89984.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="210" mass="24635" checksum="35BEC51C5DB1B4E3" modified="2007-04-03" version="1">MKETYIEIAHQIGKGWNTLSKYIQRSVNAISHLLATLELHFSNDIICNQTSEETLQSSRFNIINDLTTRIKNLSSELRSYVNQFFKEHFSNLEKTIKWINDEYSTFNHYNSDKDSKITSIKRVQVLHNSLKLCTLIKSNYDFILSFTCIIANNIDEFVQQKLIDSNKKYPNNSSTPFDNKVLDEIHKIEKFNCYNCQAELEIISNYLEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWW1</accession>
    <name>Q5CWW1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the STK19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89969.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627693.1">
        <property type="nucleotide sequence ID" value="XM_627693.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWW1"/>
    <dbReference type="GeneID" id="3375714"/>
    <dbReference type="KEGG" id="cpv:cgd6_3500"/>
    <dbReference type="InParanoid" id="Q5CWW1"/>
    <dbReference type="OMA" id="MALREEC"/>
    <dbReference type="OrthoDB" id="10261701at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018865">
        <property type="entry name" value="STK19-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15243:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE 19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10494">
        <property type="entry name" value="Stk19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00093458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89969.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="214" mass="25060" checksum="FF0FCA26C8277080" modified="2005-04-12" version="1">MLVKDGELRKLKVPRSLSYKNITSSIGYSLKSDILRVLKQRIQEKYSNLECQNRLNGCFLECLFNNENNNILLQNILNLIKENIFQNYKTISINNKHLLDYLSLICIQWKSQYKICQSHQTNFSGDFLLNLLIKFGILRSDASDLHSLIFTTPSMGLFIQYLESGNTVIINSLKRSKYKELFEDKFNTLKLGKSLLPLDFHLRDLHGNRNYKRM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWY3</accession>
    <name>Q5CWY3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_3260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627671.1">
        <property type="nucleotide sequence ID" value="XM_627671.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWY3"/>
    <dbReference type="FunCoup" id="Q5CWY3">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="3375697"/>
    <dbReference type="KEGG" id="cpv:cgd6_3260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3260"/>
    <dbReference type="InParanoid" id="Q5CWY3"/>
    <dbReference type="OMA" id="CPNISIT"/>
    <dbReference type="OrthoDB" id="360402at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="876" mass="103360" checksum="4D5EDD5E0AE22BC5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWZ9</accession>
    <name>Q5CWZ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_3090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89939.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627655.1">
        <property type="nucleotide sequence ID" value="XM_627655.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3375684"/>
    <dbReference type="KEGG" id="cpv:cgd6_3090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3090"/>
    <dbReference type="InParanoid" id="Q5CWZ9"/>
    <dbReference type="OMA" id="SCKESKY"/>
    <dbReference type="OrthoDB" id="5945655at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89939.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1498" mass="175468" checksum="0B12F25B0C2B4D3E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX12</accession>
    <name>Q5CX12_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cullin domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_2940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627642.1">
        <property type="nucleotide sequence ID" value="XM_627642.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3375671"/>
    <dbReference type="KEGG" id="cpv:cgd6_2940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2940"/>
    <dbReference type="InParanoid" id="Q5CX12"/>
    <dbReference type="OMA" id="ENTEIMD"/>
    <dbReference type="OrthoDB" id="339337at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007091">
        <property type="term" value="P:metaphase/anaphase transition of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044554">
        <property type="entry name" value="ANAPC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45957:SF1">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="3">
        <location>
            <begin position="894"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1204"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1283"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1350"/>
            <end position="1370"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1411"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1210"/>
            <end position="1233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1256"/>
            <end position="1267"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1286"/>
            <end position="1296"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1411"/>
            <end position="1425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1467" mass="167222" checksum="3D182A7201344FFE" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX17</accession>
    <name>Q5CX17_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_2890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627637.1">
        <property type="nucleotide sequence ID" value="XM_627637.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX17"/>
    <dbReference type="GeneID" id="3376161"/>
    <dbReference type="KEGG" id="cpv:cgd6_2890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2890"/>
    <dbReference type="InParanoid" id="Q5CX17"/>
    <dbReference type="OMA" id="INCLYET"/>
    <dbReference type="OrthoDB" id="338775at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="406" mass="47167" checksum="07CDA3A921BD1C49" modified="2007-04-03" version="1">MSHIRPVIKLKGIEPIWKNSTDILSFEETSIIQKSLKHMSNEIKELKECKQSLSYLEVVDIYKRFGDLINCFVTHFDFNRVKIFSQRRSIAKYSYHILICIINIIEDKSFQLDKESLVKSCQICLNYYFPSKAIKQMESNSNKSEFDLNSSSQRFDLNRSQDLCSTPPRSSVSMDISNCLPNPSPFNLSLISPGSSSISIYQQPITRYNSSENCLSEYTNLHIQHNQEEPFSCESEFFPNEFQLPMPIEEAKRRLREKLLRKEISDMKKQKNKELDYQSDYSNLSSPLKSKSLLHSWGSEQSDKSELHIEDLAGASSENPYKSNKVVNIKHNLQTQSDFWESTKVAAQLAETLPEPHRTRRIRKEIYQQSIERSVELLKSLGICRNFRPSVLTKTMIHTVECIIDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX29</accession>
    <name>Q5CX29_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein with signal peptide plus possible GPI signal or transmembrane domain at C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_2730</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627625.1">
        <property type="nucleotide sequence ID" value="XM_627625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX29"/>
    <dbReference type="GeneID" id="3376151"/>
    <dbReference type="KEGG" id="cpv:cgd6_2730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2730"/>
    <dbReference type="InParanoid" id="Q5CX29"/>
    <dbReference type="OMA" id="FQTISCI"/>
    <dbReference type="OrthoDB" id="342484at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255046" evidence="3">
        <location>
            <begin position="22"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="104"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="257" mass="29482" checksum="D0941AB40549346F" modified="2007-04-03" version="1">MRLEVLFALILLIFNINYSQGLGLRRNYNSYSESAYTDIKSSEAKDSDSDYSDVKDSSEILNKSIPLNKSEKSNYTSQVESEDEDDEPEALSNKVKSDKHFSEKDDGEDDYNSNIESSEIESSRNHSQSKKISKEEVNMPQVQYMARQQRFNLASTVNPPSDVSNINYVFLSPAAQRRIDRKISKLQKGGRYQGSMRETKAIGEWQKRYYSRPETEYSEAMSSNQGNNSIFMWVILGFIVLLLTLICICGMRFITKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX86</accession>
    <name>Q5CX86_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Kem1p-like 5'-3' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_2080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the 5'-3' exonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89865.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627568.1">
        <property type="nucleotide sequence ID" value="XM_627568.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX86"/>
    <dbReference type="GeneID" id="3376077"/>
    <dbReference type="KEGG" id="cpv:cgd6_2080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2080"/>
    <dbReference type="InParanoid" id="Q5CX86"/>
    <dbReference type="OMA" id="VYINHNE"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.750">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041385">
        <property type="entry name" value="SH3_12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047008">
        <property type="entry name" value="XRN1_SH3_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF7">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18129">
        <property type="entry name" value="SH3_12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="6">
        <location>
            <begin position="305"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="6">
        <location>
            <begin position="483"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="6">
        <location>
            <begin position="569"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="domain" description="5'-3' exoribonuclease 1 SH3-like" evidence="7">
        <location>
            <begin position="1344"/>
            <end position="1418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF18129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89865.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1588" mass="184068" checksum="0E1E37A28269A689" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXD1</accession>
    <name>Q5CXD1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Yju2p / cwf16-like Zn finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_1560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90127.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627523.1">
        <property type="nucleotide sequence ID" value="XM_627523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXD1"/>
    <dbReference type="STRING" id="353152.Q5CXD1"/>
    <dbReference type="GeneID" id="3375872"/>
    <dbReference type="KEGG" id="cpv:cgd6_1560"/>
    <dbReference type="InParanoid" id="Q5CXD1"/>
    <dbReference type="OMA" id="FTIRCNG"/>
    <dbReference type="OrthoDB" id="674963at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007590">
        <property type="entry name" value="Saf4/Yju2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12111:SF1">
        <property type="entry name" value="SPLICING FACTOR YJU2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04502">
        <property type="entry name" value="Saf4_Yju2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90127.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="270" mass="31476" checksum="DEBC15A9627CEC12" modified="2005-04-12" version="1" fragment="single">KMSERKVLNRYFPPDFDPKKLEESKKLLKKSKPNSRGGGYRKKKLLNIRMLYPFTIRCNGCEVYHYVGTKFNSKVEKVQSESYLGIPIWRFYGRCTQCGNEIVFKTDPKSGDYILESGAKQNFNMNNKEVVKKKSEDDFESKVINSVLESRSMEELEILKNLNKRLMNREATELNALKHILDENEIIPEDQFITPTDNKCNEIISDRERQLITNSVRNCIDSYEENPKFQKKLGSCVVNSDGSKRLNAAVKVKEKNSKDLFFNYYDTESE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXP4</accession>
    <name>Q5CXP4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible 2 transmembrane domains, low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_5430</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628686.1">
        <property type="nucleotide sequence ID" value="XM_628684.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXP4"/>
    <dbReference type="GeneID" id="3372156"/>
    <dbReference type="KEGG" id="cpv:cgd7_5430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5430"/>
    <dbReference type="InParanoid" id="Q5CXP4"/>
    <dbReference type="OMA" id="CRTNIAN"/>
    <dbReference type="OrthoDB" id="342892at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="581" mass="67422" checksum="A38C162FF393FDCC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXP8</accession>
    <name>Q5CXP8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_5390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628682.1">
        <property type="nucleotide sequence ID" value="XM_628680.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXP8"/>
    <dbReference type="GeneID" id="3372148"/>
    <dbReference type="KEGG" id="cpv:cgd7_5390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5390"/>
    <dbReference type="InParanoid" id="Q5CXP8"/>
    <dbReference type="OrthoDB" id="341555at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="327" mass="36553" checksum="EF99B666FBF4CA5E" modified="2005-04-12" version="1">MICNIVNYTRGRIWCPKGFNVIFPPKALEKYEFGEEIPEDETYKIISGTFDENDVVSDEVVEDIFETLNEISENKNDQEFPINFNDTSSRGQDTISNNLFTSSSRYVKKSQADIQAVQMRGMGIDMENNVEFLTNEFENSSKNCIKDKGICGDSKGLKDDESEIGVGKRKWDDIGNNNNIMLRRLQEMAFGGTLATQMFEPGLEKELEFGPLSGVYMGNYGNVFGKETEEEIIISGNLGQLIGNNQATTAPLLQYVEKKAQFFKEPACSLVVAVHSTNCTPLQCKSPFLKEINHILRDWAVFVLQADPDSGSNLIPNGKDLPFTNAG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXQ2</accession>
    <name>Q5CXQ2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM8</name>
        <name evidence="11" type="ORF">cgd7_5350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90660.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628678.1">
        <property type="nucleotide sequence ID" value="XM_628676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXQ2"/>
    <dbReference type="FunCoup" id="Q5CXQ2">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXQ2"/>
    <dbReference type="GeneID" id="3371757"/>
    <dbReference type="KEGG" id="cpv:cgd7_5350"/>
    <dbReference type="InParanoid" id="Q5CXQ2"/>
    <dbReference type="OMA" id="TLESYMN"/>
    <dbReference type="OrthoDB" id="10263346at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01727">
        <property type="entry name" value="LSm8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034103">
        <property type="entry name" value="Lsm8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044642">
        <property type="entry name" value="PTHR15588"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588">
        <property type="entry name" value="LSM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15588:SF9">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="2"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK90660.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="99" mass="11291" checksum="59545D175DB058E9" modified="2005-04-12" version="1" fragment="single">QMNSSTLEQFINKTVSVLTVDNKVYVGNLVGFDQLTNIVLQNCFEKIYNKDLNKVETVSMESLVLRGDCIGMVGEGYEDLTQNFEKDQQVYKRQKISDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXZ6</accession>
    <name>Q5CXZ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Low complexity protein with coiled coil regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_4300</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628584.1">
        <property type="nucleotide sequence ID" value="XM_628582.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXZ6"/>
    <dbReference type="GeneID" id="3372162"/>
    <dbReference type="KEGG" id="cpv:cgd7_4300"/>
    <dbReference type="InParanoid" id="Q5CXZ6"/>
    <dbReference type="OrthoDB" id="340402at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="167" mass="19608" checksum="D327740CC84514B8" modified="2005-04-12" version="1">MGQLTNWCNQVEKYIEIKGQKKGLFRAKKKSLLANFEKVLVQSREYINNTLRPEVKKCSAICSLLEQQFNEVESIRTKVNNMSRSGSYSATETSELVSKYNEISKTFLREIVHNNKKILFWNATVEEIHNQVKEMVNLFNEQIDMLSREFNSKMIFTLFLPQKVIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY21</accession>
    <name>Q5CY21_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cryptopsoridial mucin, large thr stretch, signal peptide sequence</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628559.1">
        <property type="nucleotide sequence ID" value="XM_628557.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY21"/>
    <dbReference type="GeneID" id="3372065"/>
    <dbReference type="KEGG" id="cpv:cgd7_4020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4020"/>
    <dbReference type="InParanoid" id="Q5CY21"/>
    <dbReference type="OMA" id="DTMDIAN"/>
    <dbReference type="OrthoDB" id="344047at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="518"/>
            <end position="580"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="801"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="849"/>
            <end position="868"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="883"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1186"/>
            <end position="1205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1334"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1489"/>
            <end position="1591"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1765"/>
            <end position="1791"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1888"/>
            <end position="1937"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="883"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1337"/>
            <end position="1354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1381"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1894"/>
            <end position="1920"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1937" mass="202605" checksum="653E4360C34B8938" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY35</accession>
    <name>Q5CY35_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_3830</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628545.1">
        <property type="nucleotide sequence ID" value="XM_628543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY35"/>
    <dbReference type="GeneID" id="3372131"/>
    <dbReference type="KEGG" id="cpv:cgd7_3830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3830"/>
    <dbReference type="InParanoid" id="Q5CY35"/>
    <dbReference type="OMA" id="NIDMEGY"/>
    <dbReference type="OrthoDB" id="339108at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254534" description="Secreted protein" evidence="2">
        <location>
            <begin position="23"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="563"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="575"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="603" mass="68993" checksum="671D844AC6C465AE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY67</accession>
    <name>Q5CY67_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Ribosomal protein L1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628513.1">
        <property type="nucleotide sequence ID" value="XM_628511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY67"/>
    <dbReference type="STRING" id="353152.Q5CY67"/>
    <dbReference type="GeneID" id="3372104"/>
    <dbReference type="KEGG" id="cpv:cgd7_3490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3490"/>
    <dbReference type="InParanoid" id="Q5CY67"/>
    <dbReference type="OMA" id="KKDTIRH"/>
    <dbReference type="OrthoDB" id="10251727at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="250" mass="28713" checksum="01416B6CC65FC9C2" modified="2005-04-12" version="1">MDRFKLSNPIKAQKHLEDAVNALKELVKIKKCPEDLLFNKNSQFITLIISLSNTPEFVKSKHVRIKIPNSLYKHPGNEVCLFVKDPQRKWKELISSSSIEPKVVSKVIGVSKLSKKYSTYKDRRELCSGYDLFLSDDRIIEKMPKLLGSYFIKANKMPIAIKIRESNFKNSLESALSSTFMSIKKGKCIGIRVARVDMNTKQVVQNLIEAIKQVSDFFEGNGSKNWRNSIESLYIQSTNTMSLPIWFKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY89</accession>
    <name>Q5CY89_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Importin/karyopherin (Arm repeats)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_3270</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628491.1">
        <property type="nucleotide sequence ID" value="XM_628489.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY89"/>
    <dbReference type="FunCoup" id="Q5CY89">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY89"/>
    <dbReference type="GeneID" id="3372043"/>
    <dbReference type="KEGG" id="cpv:cgd7_3270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3270"/>
    <dbReference type="InParanoid" id="Q5CY89"/>
    <dbReference type="OMA" id="NDSCYQD"/>
    <dbReference type="OrthoDB" id="543373at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006606">
        <property type="term" value="P:protein import into nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000357">
        <property type="entry name" value="HEAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040122">
        <property type="entry name" value="Importin_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041653">
        <property type="entry name" value="Importin_rep_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057672">
        <property type="entry name" value="TPR_IPO4/5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10527">
        <property type="entry name" value="IMPORTIN BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02985">
        <property type="entry name" value="HEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18808">
        <property type="entry name" value="Importin_rep_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25780">
        <property type="entry name" value="TPR_IPO5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="IPO4/5-like TPR repeats" evidence="8">
        <location>
            <begin position="108"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1127" mass="127557" checksum="27D5AABEBF8890F0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYI7</accession>
    <name>Q5CYI7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">guanylate kinase</fullName>
            <ecNumber evidence="2">2.7.4.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_2190</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the guanylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.8" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90247.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628393.1">
        <property type="nucleotide sequence ID" value="XM_628391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYI7"/>
    <dbReference type="FunCoup" id="Q5CYI7">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYI7"/>
    <dbReference type="GeneID" id="3371895"/>
    <dbReference type="KEGG" id="cpv:cgd7_2190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2190"/>
    <dbReference type="InParanoid" id="Q5CYI7"/>
    <dbReference type="OMA" id="NFITHEV"/>
    <dbReference type="OrthoDB" id="6334211at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004385">
        <property type="term" value="F:GMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00071">
        <property type="entry name" value="GMPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.63.10:FF:000002">
        <property type="entry name" value="Guanylate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.10">
        <property type="entry name" value="Guanylate Kinase phosphate binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008145">
        <property type="entry name" value="GK/Ca_channel_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008144">
        <property type="entry name" value="Guanylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017665">
        <property type="entry name" value="Guanylate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03263">
        <property type="entry name" value="guanyl_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117:SF13">
        <property type="entry name" value="GUANYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23117">
        <property type="entry name" value="GUANYLATE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00625">
        <property type="entry name" value="Guanylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00072">
        <property type="entry name" value="GuKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50052">
        <property type="entry name" value="GUANYLATE_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Guanylate kinase-like" evidence="7">
        <location>
            <begin position="2"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90247.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="193" mass="22327" checksum="81A91770285FBEB5" modified="2005-04-12" version="1">MKDILVICGPSGVGKGTLISHLMQEFPDKFGFSISHTSRSPRGKESNGVEYYFCSNEEFINMISMDGFVEYAEVHKYFYGTSKQAIEDIINQRKICLIDIDIQGVEQIQKSSFGDRAYYIGILPKSQMDLEERLRKRKTDSEQAIQIRLQNSVEEIERINRNPNIYKLVNDDLKTACDEIARLVKSYWEDISY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYM3</accession>
    <name>Q5CYM3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oocyst wall protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_1800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90221.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628357.1">
        <property type="nucleotide sequence ID" value="XM_628355.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYM3"/>
    <dbReference type="GeneID" id="3371741"/>
    <dbReference type="KEGG" id="cpv:cgd7_1800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1800"/>
    <dbReference type="InParanoid" id="Q5CYM3"/>
    <dbReference type="OMA" id="MGEHINP"/>
    <dbReference type="OrthoDB" id="7250310at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157:SF2">
        <property type="entry name" value="EB DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37157">
        <property type="entry name" value="PRION-LIKE-(Q/N-RICH) DOMAIN-BEARING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90221.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1378" mass="153667" checksum="F9380ACDC2C6130B" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYR9</accession>
    <name>Q5CYR9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd7_1260</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628311.1">
        <property type="nucleotide sequence ID" value="XM_628309.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYR9"/>
    <dbReference type="SMR" id="Q5CYR9"/>
    <dbReference type="STRING" id="353152.Q5CYR9"/>
    <dbReference type="GeneID" id="3371779"/>
    <dbReference type="KEGG" id="cpv:cgd7_1260"/>
    <dbReference type="InParanoid" id="Q5CYR9"/>
    <dbReference type="OMA" id="ECKNEHA"/>
    <dbReference type="OrthoDB" id="346907at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="282"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="403"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="819"/>
            <end position="854"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="888"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="950"/>
            <end position="985"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="172"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="604"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="648"/>
            <end position="668"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="31"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="650"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="432"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAK90682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1042" mass="115540" checksum="972BEEBC97AB406D" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYS9</accession>
    <name>Q5CYS9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_1160</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628301.1">
        <property type="nucleotide sequence ID" value="XM_628299.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYS9"/>
    <dbReference type="GeneID" id="3371847"/>
    <dbReference type="KEGG" id="cpv:cgd7_1160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1160"/>
    <dbReference type="InParanoid" id="Q5CYS9"/>
    <dbReference type="OMA" id="CHILISK"/>
    <dbReference type="OrthoDB" id="5600252at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17917">
        <property type="entry name" value="DEXHc_RHA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1080">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54768">
        <property type="entry name" value="dsRNA-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="483"/>
            <end position="664"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="744"/>
            <end position="934"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="706"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="34"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="709"/>
            <end position="723"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1396" mass="160592" checksum="871D387B80A6F551" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYY0</accession>
    <name>Q5CYY0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628250.1">
        <property type="nucleotide sequence ID" value="XM_628248.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYY0"/>
    <dbReference type="GeneID" id="3372003"/>
    <dbReference type="KEGG" id="cpv:cgd7_600"/>
    <dbReference type="InParanoid" id="Q5CYY0"/>
    <dbReference type="OrthoDB" id="10327630at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="58"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="60"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="124" mass="14487" checksum="6F57A6FF6C4DFC91" modified="2005-04-12" version="1">MRNLRSATLLFRWDKKSLPPDLHRLDAPWIHLLKVQVQRDKDLQNWIQKQWDDSRDKFFKSRGLKPPKRKKTIEQAIGTSEEKAQVNDKTKKKKGSKSNDDTEGSDKPPQVANDDMRFAAKMVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPM2</accession>
    <name>A3FPM2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CAF1B/HIR1 beta-propeller domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd7_560</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat HIR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388368.1">
        <property type="nucleotide sequence ID" value="XM_001388331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPM2"/>
    <dbReference type="FunCoup" id="A3FPM2">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPM2"/>
    <dbReference type="GeneID" id="3371867"/>
    <dbReference type="KEGG" id="cpv:cgd7_560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_560"/>
    <dbReference type="InParanoid" id="A3FPM2"/>
    <dbReference type="OMA" id="QIYWHES"/>
    <dbReference type="OrthoDB" id="538223at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033186">
        <property type="term" value="C:CAF-1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006335">
        <property type="term" value="P:DNA replication-dependent chromatin assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055410">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045145">
        <property type="entry name" value="PTHR15271"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15271:SF4">
        <property type="entry name" value="CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24105">
        <property type="entry name" value="Beta-prop_CAF1B_HIR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117289">
        <property type="entry name" value="Nucleoporin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 9" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="1"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="21"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="61"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="129"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="164"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="CAF1B/HIR1 beta-propeller" evidence="11">
        <location>
            <begin position="358"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="198"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="587"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="10">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="10">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="600"/>
            <end position="609"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF24105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="664" mass="74002" checksum="4C4256645E95E99C" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPQ2</accession>
    <name>A3FPQ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Pleiotropic regulator 1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_3960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat PRL1/PRL2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388398.1">
        <property type="nucleotide sequence ID" value="XM_001388361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPQ2"/>
    <dbReference type="FunCoup" id="A3FPQ2">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPQ2"/>
    <dbReference type="GeneID" id="3371818"/>
    <dbReference type="KEGG" id="cpv:cgd7_3960"/>
    <dbReference type="InParanoid" id="A3FPQ2"/>
    <dbReference type="OrthoDB" id="10256122at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045241">
        <property type="entry name" value="Prp46/PLRG1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923:SF0">
        <property type="entry name" value="PLEIOTROPIC REGULATOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19923">
        <property type="entry name" value="WD40 REPEAT PROTEINPRL1/PRL2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 4" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="127"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="169"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="211"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="253"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="4">
        <location>
            <begin position="388"/>
            <end position="427"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="427" mass="48756" checksum="BDDF426C99826C03" modified="2007-04-03" version="1">MNLSAFKMADYFQEVVLNRLNFFSSEQGYIRNSFSKQYGNINKLLKARNEYCKSQLGDQVSKSMPCDALAPYRAEYKYNSLNLYGNTEAPLYKKKRTDELNISNINKYLARDHGIKWAPRFKLNKVISGHKGWVRSIAVDPSNNFFVSGSSDKLIKFWDINSGILKLTLIGHIAAVRKVLFSERHPFLFSCSEDKTMKCWDLEQNRIVRNYARHSSGIYCLDIHPRLDIVATGSRDGSVVLWDIRTRESIHLFKNHKAAISSILMQSIEPQLISGSYDRTIRTWDIVAGKARDILTRHIKPIRALAKHPIHYSFLSAGADCIKIWEGEDSTYLRDLSSSQSIINTITIRSQENNSIVLAGCDNGQLHFWDYETGTLYDTIQSNIQPGSVEAENSILDCKFDRTESVLITGECDKTIKIWNLKTAELI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPS3</accession>
    <name>A3FPS3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd6_620</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. The alpha chain contains the catalytic site.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51496.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388302.1">
        <property type="nucleotide sequence ID" value="XM_001388265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPS3"/>
    <dbReference type="FunCoup" id="A3FPS3">
        <property type="interactions" value="269"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPS3"/>
    <dbReference type="GeneID" id="3375927"/>
    <dbReference type="KEGG" id="cpv:cgd6_620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_620"/>
    <dbReference type="InParanoid" id="A3FPS3"/>
    <dbReference type="OMA" id="ECHMIEW"/>
    <dbReference type="OrthoDB" id="10254671at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14132">
        <property type="entry name" value="STKc_CK2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000059">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000088">
        <property type="entry name" value="Casein kinase II subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045216">
        <property type="entry name" value="CK2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24054:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 10 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 11" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="44"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="79"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00059329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAZ51496.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="341" mass="40193" checksum="47F69024215AF053" modified="2007-04-03" version="1">MSNNSNSANKWPLPRLYSDVNIYKPREYWDYESFQIEYSNPNNYEIIKKVGRGKYSEVFEGINVITNEKVIIKVLRPVKRKKIKREIKILYNLHGGPNIVKLLDIIKDPSSGTISLVFECLDNVDFKSLFPTFNDNDIRFYIYQILKALDFCHSQGIMHRDVKPHNVIIDPKKKELRLIDWGLAEFYHPRQDYNVRVASRYYKGPELLIDFQYYDYSLDIWSLGCVLAGLIFKRDPFFCGVDNNDQLVKIARVLGTDGLFEYLAKYKKQLEPYFDDLLGRHTRKPWSKFINAENQHLVNPVVLDLLDKMLVYDHAERILPREALAHPYFEKIHQEEQKGSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ12</accession>
    <name>A3FQ12_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Scully CG7113-PA, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388092.1">
        <property type="nucleotide sequence ID" value="XM_001388055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ12"/>
    <dbReference type="FunCoup" id="A3FQ12">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ12"/>
    <dbReference type="GeneID" id="3373948"/>
    <dbReference type="KEGG" id="cpv:cgd3_330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_330"/>
    <dbReference type="InParanoid" id="A3FQ12"/>
    <dbReference type="OMA" id="RHIFEND"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658:SF8">
        <property type="entry name" value="17-BETA-HYDROXYSTEROID DEHYDROGENASE 14-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43658">
        <property type="entry name" value="SHORT-CHAIN DEHYDROGENASE/REDUCTASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="284" mass="30663" checksum="41BC1D3FDDCC1119" modified="2007-04-03" version="1">MKIEDSVIVVTGGMSGLGKAVVEELLKENPRKVCLMDAVLKEGELEEEPINKCEKYCVDVTDYNCIKSAAKSIIDKYSKIDAVVHCAGITHCPTPIVQKDDNGKIMENNEDIPEIWGKVVNVNVIGTLNVIHCLSPFLAMNQGNSHGFEKGVFILVSSSTARDGPAQNQGYIASKGAINSLTLPLARELGPLGIRVVTIGPGVFDTPMSKHAMSEKTSSTLLKSIPLGRFGVPNEFAETVVNVGLKSEYISGEIIYLDGAWRPPFITSGSVRRLSIQKSSSNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ33</accession>
    <name>A3FQ33_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">UbiA prenyltransferase family member (3I27), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_2460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UbiA prenyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388113.1">
        <property type="nucleotide sequence ID" value="XM_001388076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ33"/>
    <dbReference type="STRING" id="353152.A3FQ33"/>
    <dbReference type="GeneID" id="3374074"/>
    <dbReference type="KEGG" id="cpv:cgd3_2460"/>
    <dbReference type="InParanoid" id="A3FQ33"/>
    <dbReference type="OrthoDB" id="18170at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016765">
        <property type="term" value="F:transferase activity, transferring alkyl or aryl (other than methyl) groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006744">
        <property type="term" value="P:ubiquinone biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.357.140">
        <property type="entry name" value="UbiA prenyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039653">
        <property type="entry name" value="Prenyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044878">
        <property type="entry name" value="UbiA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048:SF28">
        <property type="entry name" value="4-HYDROXYBENZOATE POLYPRENYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11048">
        <property type="entry name" value="PRENYLTRANSFERASES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="50"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="118" mass="13289" checksum="074BD7EF18985A4B" modified="2007-04-03" version="1">MNTIRPNYGFINSSFSKTCIQSVFRTSRGICKMNFKHYIKLYRINNPTGFWLLFIPTFGSLTLASNSLLPKANITALFALGSVASRSAGCVINDLADRQFDSKVVFHTFFIHYHLLSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ42</accession>
    <name>A3FQ42_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">deoxyribose-phosphate aldolase</fullName>
            <ecNumber evidence="3">4.1.2.4</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">2-deoxy-D-ribose 5-phosphate aldolase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">Phosphodeoxyriboaldolase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd3_3200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde</text>
            <dbReference type="Rhea" id="RHEA:12821"/>
            <dbReference type="ChEBI" id="CHEBI:15343"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="ChEBI" id="CHEBI:62877"/>
            <dbReference type="EC" id="4.1.2.4"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.2.4" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51450.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388122.1">
        <property type="nucleotide sequence ID" value="XM_001388085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ42"/>
    <dbReference type="FunCoup" id="A3FQ42">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ42"/>
    <dbReference type="GeneID" id="3373824"/>
    <dbReference type="KEGG" id="cpv:cgd3_3200"/>
    <dbReference type="InParanoid" id="A3FQ42"/>
    <dbReference type="OMA" id="INGETPC"/>
    <dbReference type="OrthoDB" id="70823at2759"/>
    <dbReference type="UniPathway" id="UPA00002">
        <property type="reaction ID" value="UER00468"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004139">
        <property type="term" value="F:deoxyribose-phosphate aldolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016052">
        <property type="term" value="P:carbohydrate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009264">
        <property type="term" value="P:deoxyribonucleotide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046386">
        <property type="term" value="P:deoxyribose phosphate catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011343">
        <property type="entry name" value="DeoC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002915">
        <property type="entry name" value="DeoC/FbaB/LacD_aldolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10889:SF3">
        <property type="entry name" value="DEOXYRIBOSE-PHOSPHATE ALDOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01133">
        <property type="entry name" value="DeoC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51569">
        <property type="entry name" value="Aldolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0704">Schiff base</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009473"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00031814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00032755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51450.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="394" mass="43590" checksum="CF8C85D67C95C5B1" modified="2007-04-03" version="1">MKEDQKEFLRKVANVCELTLYTSEMNNKLLKNAIREASSDQLLAPVSISTYPQFIPSVKHSLPENSSTALSTVVAWPRGDGCSEAIDAEIYNAVEYYKVHEIEYVVDYRHQLLLQQMEKVINEIARVKSLIGPNILLKVVLEIGEINEASRLSSLVRCAILGGADFIVTCTGKVKKGLNSQDLKQLLIEVKSSIEGESPCDKEIAAGDDEEVLEGLQAHYDESFVKGTLILPNRLRYLQKRKVGIKLQGGVSSLDIAREFIKQVEDVLGNEYVSSPNTFRIGSSTLHPLIIQELLGIDDELRIVHTLGIKPINAEQVNQEDNISSPENELVGISHPSAPISSNQTREKIGSQEVIDINKDIIKVEALNGDKTIISDSDLVGNKSKVISVEYLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ79</accession>
    <name>A3FQ79_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1 10">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="1 10">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_1960</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2010-09" db="PDB data bank">
            <title>Crystal structure of MapK from Cryptosporidium Parvum, cgd2_1960.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Lew J."/>
                <person name="Lin Y.H."/>
                <person name="Sullivan H."/>
                <person name="Hassanali A."/>
                <person name="Kozieradzki I."/>
                <person name="Cossar D."/>
                <person name="Arrowsmith C.H."/>
                <person name="Bochkarev A."/>
                <person name="Bountra C."/>
                <person name="Edwards A.M."/>
                <person name="Weigelt J."/>
                <person name="Hui R."/>
                <person name="Neculai A.M."/>
                <person name="Hutchinson A."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.37 ANGSTROMS) OF 4-390</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="1 10"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388215.1">
        <property type="nucleotide sequence ID" value="XM_001388178.1"/>
    </dbReference>
    <dbReference type="PDB" id="3OZ6">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.37 A"/>
        <property type="chains" value="A/B=4-390"/>
    </dbReference>
    <dbReference type="PDBsum" id="3OZ6"/>
    <dbReference type="AlphaFoldDB" id="A3FQ79"/>
    <dbReference type="SMR" id="A3FQ79"/>
    <dbReference type="STRING" id="353152.A3FQ79"/>
    <dbReference type="BindingDB" id="A3FQ79"/>
    <dbReference type="ChEMBL" id="CHEMBL4295632"/>
    <dbReference type="GeneID" id="3373441"/>
    <dbReference type="KEGG" id="cpv:cgd2_1960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1960"/>
    <dbReference type="InParanoid" id="A3FQ79"/>
    <dbReference type="OMA" id="MDVKPIS"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="EvolutionaryTrace" id="A3FQ79"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106310">
        <property type="term" value="F:protein serine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07852">
        <property type="entry name" value="STKc_MAPK15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000238">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000166">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="15" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 10 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 10 13" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="13"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="433"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="433"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="43"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012411"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAZ51388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="3OZ6"/>
        </source>
    </evidence>
    <sequence length="710" mass="80116" checksum="6F15FD562BE58567" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ88</accession>
    <name>A3FQ88_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription factor, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_2820</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPT4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388224.1">
        <property type="nucleotide sequence ID" value="XM_001388187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ88"/>
    <dbReference type="FunCoup" id="A3FQ88">
        <property type="interactions" value="293"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ88"/>
    <dbReference type="GeneID" id="3373548"/>
    <dbReference type="KEGG" id="cpv:cgd2_2820"/>
    <dbReference type="InParanoid" id="A3FQ88"/>
    <dbReference type="OMA" id="FDGMIAV"/>
    <dbReference type="OrthoDB" id="248751at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000993">
        <property type="term" value="F:RNA polymerase II complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140673">
        <property type="term" value="P:transcription elongation-coupled chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07973">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009287">
        <property type="entry name" value="Spt4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022800">
        <property type="entry name" value="Spt4/RpoE2_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038510">
        <property type="entry name" value="Spt4_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882">
        <property type="entry name" value="SUPPRESSOR OF TY 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12882:SF1">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06093">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01389">
        <property type="entry name" value="Spt4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="Spt4/RpoE2 zinc finger" evidence="5">
        <location>
            <begin position="32"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010464"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="124" mass="14069" checksum="5F71562B3B08467A" modified="2007-04-03" version="1" fragment="single">FLIHLLGTRKIIQIRDSKTNKSTTKENYVLRLRACLSCRIILSDQQFYEGGCPNCTHLAMEFDRQKVNSCTSMSFKGMISMLKPNESWVARYNKLLPNIVPGCYAVSVSGDMVSDDEGNYNGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ95</accession>
    <name>A3FQ95_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Replication factor C subunit 5, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51404.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388231.1">
        <property type="nucleotide sequence ID" value="XM_001388194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ95"/>
    <dbReference type="FunCoup" id="A3FQ95">
        <property type="interactions" value="384"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ95"/>
    <dbReference type="GeneID" id="3373431"/>
    <dbReference type="KEGG" id="cpv:cgd2_3180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3180"/>
    <dbReference type="InParanoid" id="A3FQ95"/>
    <dbReference type="OMA" id="LKADIMH"/>
    <dbReference type="OrthoDB" id="761538at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF1">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13177">
        <property type="entry name" value="DNA_pol3_delta2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21960">
        <property type="entry name" value="RCF1-5-like_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22534">
        <property type="entry name" value="RFC_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51404.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="345" mass="38669" checksum="223549E84053B994" modified="2007-04-03" version="1" fragment="single">MLWIDKYQPRYLRDLKCNKELNSLLEKITSNSNGNIPHLLFYGPSGGGKKVRISSVLHEIFGDSVDKVKADMIKPEGTNSEFVLCQSPHHMQISAPDLGTKDGIVTQYLIKQLSSQMGANSFFSKGPNYRVFTILEADVLSLKAQAGLRRTMEKYSNNSRLILHCEQLSSIIPPLRSRCLCIRVPLPSPEEVLQVLRFISNSENLQVPNNYLEQIVTESECNLRRAILILETAHTQSFSNPPSALKLPWQKVCIDIATSIVKNPHPKTLLDVREPLYDLLCSCIPADLILVTLTKQLLSIVSASAQPIIINAAAHYAHTLKLGSKDIWHIEAFLAQVMNCHKYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQA6</accession>
    <name>A3FQA6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_4070</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388242.1">
        <property type="nucleotide sequence ID" value="XM_001388205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQA6"/>
    <dbReference type="SMR" id="A3FQA6"/>
    <dbReference type="STRING" id="353152.A3FQA6"/>
    <dbReference type="GeneID" id="3373665"/>
    <dbReference type="KEGG" id="cpv:cgd2_4070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4070"/>
    <dbReference type="InParanoid" id="A3FQA6"/>
    <dbReference type="OMA" id="MTLMINT"/>
    <dbReference type="OrthoDB" id="1861185at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045003">
        <property type="term" value="P:double-strand break repair via synthesis-dependent strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071140">
        <property type="term" value="P:resolution of mitotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090656">
        <property type="term" value="P:t-circle formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000722">
        <property type="term" value="P:telomere maintenance via recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46487:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN XRCC3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="1">
        <location>
            <begin position="34"/>
            <end position="236"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="304" mass="34439" checksum="F5C3211018F56FDA" modified="2007-04-03" version="1">MKKESGKGGGFELTWWRSRGAEEIISTSEQMLMDDTRLSTGSNVVDKAFNGGIPKRILFEITGEAGTGKTQWCLTLITSVLLRNLDFSKVMGELNSDIGIVCVLYTENGVFSNGRLSEILKSKLEFEYLKANSKEKLDNNEDDLLNILHNKLMNYVKVYKINTLEDLNIFLQRVIPGICLNHKIDAIFIDSITNLYRSKVSFSENSSASTSLIQFSNVFKRISVDQDSWLIVTNQTTTELNEFHIPGSNIFGNKQKPSLGLIWSNSINWRIFLSKSISPSFEKDLNISYRELRVELSSEIPKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQD5</accession>
    <name>A3FQD5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">Vesicle-trafficking protein SEC22b</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">SEC22 vesicle-trafficking protein homolog B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">cgd1_1890</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="13">Endoplasmic reticulum-Golgi intermediate compartment membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388157.1">
        <property type="nucleotide sequence ID" value="XM_001388120.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQD5"/>
    <dbReference type="FunCoup" id="A3FQD5">
        <property type="interactions" value="481"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQD5"/>
    <dbReference type="GeneID" id="3371412"/>
    <dbReference type="KEGG" id="cpv:cgd1_1890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1890"/>
    <dbReference type="InParanoid" id="A3FQD5"/>
    <dbReference type="OMA" id="FIYWRFF"/>
    <dbReference type="OrthoDB" id="1719357at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033116">
        <property type="term" value="C:endoplasmic reticulum-Golgi intermediate compartment membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005484">
        <property type="term" value="F:SNAP receptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15866">
        <property type="entry name" value="R-SNARE_SEC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044565">
        <property type="entry name" value="Sec22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45837">
        <property type="entry name" value="VESICLE-TRAFFICKING PROTEIN SEC22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11 16" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="10" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="12 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="206"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="18">
        <location>
            <begin position="6"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="19">
        <location>
            <begin position="144"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00024187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00024248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00033315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EAZ51334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="226" mass="26039" checksum="949EF4DCE395318F" modified="2007-04-03" version="1">MCETTFIGRASDGLILTETWDDLSSNRSLQSYKHQAKQILKSIGNDQGVEKCSIDSGNYVFHYIVNDGIIYMTLSGKSYPKKLAFSFLDEIKRLFIEELGREFANRDEFKSLIDAIDKPYYFIKFDRIIQRCKSEYKDPNSNKSLQKLNDSLIEVTNIMRRNVDDILLRGENLNDVERKANDLKFASLEFSRAAKKLSLHALIQKYAPILALSAIVLIIIIWKLIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQD6</accession>
    <name>A3FQD6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd1_1950</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388158.1">
        <property type="nucleotide sequence ID" value="XM_001388121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQD6"/>
    <dbReference type="STRING" id="353152.A3FQD6"/>
    <dbReference type="GeneID" id="3371409"/>
    <dbReference type="KEGG" id="cpv:cgd1_1950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1950"/>
    <dbReference type="InParanoid" id="A3FQD6"/>
    <dbReference type="OMA" id="NTTIFCQ"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029067">
        <property type="entry name" value="CDC48_domain_2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045191">
        <property type="entry name" value="MBR1/2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937:SF65">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE ARK2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22937">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF165"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54585">
        <property type="entry name" value="Cdc48 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="6 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="11">
        <location>
            <begin position="363"/>
            <end position="404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="413" mass="47170" checksum="C1BC3E0FF73E97FE" modified="2007-04-03" version="1">MDSGEQLKNVLSRIQLLPWKEQHDIELLLKVLRKYEVENRVLKPFDKVYIDERNYFVVLFCDPVEGGALSESTQVFANGKPLMSLQKVHFLALPPFNAALSPLAQKVSTIRLNRLLQDQREFEREIEVSNSEVENLCGSDQLCRLYIEPYFQKKRKEPIYVGRKVEIDGITFLVWACEPTQVGVIDGNTAVYINWDCFGEFKRIHVMPFSDTLPQTYSFDIFQDYLKPFLSRYTFHPFSEGESFTYNGVQFKIIATDPAGVKARIGDNTTIYCQGSLTPSIVDLLPVHLLENIIRLPPRSRPFSILQALAHLPPSDVDRIFGSADSNNSRGINNEIVNKITQKSYYYGEGNETCSSSDDAPLCTVCLSEVNEGDFVVRLDCQHIFHHQCIKEWFKMSVICPLCKVDVRGSNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQG0</accession>
    <name>A3FQG0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Fork head domain protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388182.1">
        <property type="nucleotide sequence ID" value="XM_001388145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQG0"/>
    <dbReference type="STRING" id="353152.A3FQG0"/>
    <dbReference type="GeneID" id="3371387"/>
    <dbReference type="KEGG" id="cpv:cgd1_3470"/>
    <dbReference type="InParanoid" id="A3FQG0"/>
    <dbReference type="OMA" id="KIPTANW"/>
    <dbReference type="OrthoDB" id="444265at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050923">
        <property type="entry name" value="Cell_Proc_Reg/RNA_Proc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23308">
        <property type="entry name" value="NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="1">
        <location>
            <begin position="109"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="195" mass="22913" checksum="65EDF066E07E2BF9" modified="2007-04-03" version="1" fragment="single">KKRNYYNNKMQSYKINEFGNEIHNNKINFEPSGLLAKESNSLNGVFLKYSKPSDSCNSHKKWKLYVFKYNYPHDVGKNDNTGIVHVNNDSSCGQHVYNETIPLYNNEYYLIGKDARVVNINLKEDSIEDQHAVIQHRVNKKGIPTIYIIDLDSKYGTFINDERIESRRYYELIEKDSIRFGECKNEYILLHDGMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQG6</accession>
    <name>A3FQG6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51272.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388250.1">
        <property type="nucleotide sequence ID" value="XM_001388213.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373031"/>
    <dbReference type="KEGG" id="cpv:cgd5_420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_420"/>
    <dbReference type="InParanoid" id="A3FQG6"/>
    <dbReference type="OMA" id="CCALPHN"/>
    <dbReference type="OrthoDB" id="344085at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="273"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="830"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1098"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="228"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="839"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1391"/>
            <end position="1409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51272.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1432" mass="158202" checksum="606F08939CEFAEED" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPF6</accession>
    <name>Q5CPF6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PPP4R2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625337.1">
        <property type="nucleotide sequence ID" value="XM_625337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPF6"/>
    <dbReference type="STRING" id="353152.Q5CPF6"/>
    <dbReference type="GeneID" id="3372335"/>
    <dbReference type="KEGG" id="cpv:cgd3_240"/>
    <dbReference type="InParanoid" id="Q5CPF6"/>
    <dbReference type="OrthoDB" id="341898at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015267">
        <property type="entry name" value="PPP4R2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09184">
        <property type="entry name" value="PPP4R2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009207"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="219" mass="25472" checksum="A013B3275C7463B8" modified="2005-04-12" version="1">MESISTTKDTHDTEILHFNNQSNSFQDLDHDHKIDTENINTGTDNIKIDSREELIPSLDFDDLSMIERVSKEGVDKSFNMKSNVDENEIIEWKVLKKALRKEIVLKSNQMFEKYGGLDQLDYLPYNCKLHSNLENSHLDEVSPRHKNIEYSCPDCGKSILENFLMDILEAFDCHTDFPPTIQRICELLLFPDCYNNTKSFLYALDKVCLTRISFSSFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPQ3</accession>
    <name>Q5CPQ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted, membrane-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_4470</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625461.1">
        <property type="nucleotide sequence ID" value="XM_625461.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPQ3"/>
    <dbReference type="STRING" id="353152.Q5CPQ3"/>
    <dbReference type="GeneID" id="3372430"/>
    <dbReference type="KEGG" id="cpv:cgd4_4470"/>
    <dbReference type="InParanoid" id="Q5CPQ3"/>
    <dbReference type="OMA" id="VEMWNID"/>
    <dbReference type="OrthoDB" id="344317at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="50"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="50"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="97"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="584" mass="66489" checksum="5C0E3EBA48775106" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQJ8</accession>
    <name>Q5CQJ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ORC5 like AAA+ ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87679.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625650.1">
        <property type="nucleotide sequence ID" value="XM_625650.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQJ8"/>
    <dbReference type="STRING" id="353152.Q5CQJ8"/>
    <dbReference type="GeneID" id="3372732"/>
    <dbReference type="KEGG" id="cpv:cgd4_430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_430"/>
    <dbReference type="InParanoid" id="Q5CQJ8"/>
    <dbReference type="OMA" id="DMCKNIL"/>
    <dbReference type="OrthoDB" id="365981at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020796">
        <property type="entry name" value="ORC5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047088">
        <property type="entry name" value="ORC5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12705:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14630">
        <property type="entry name" value="ORC5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 5 C-terminal" evidence="2">
        <location>
            <begin position="526"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF14630"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87679.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="739" mass="84339" checksum="18D65ED95C60F715" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQL6</accession>
    <name>Q5CQL6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_230</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87693.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625632.1">
        <property type="nucleotide sequence ID" value="XM_625632.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQL6"/>
    <dbReference type="GeneID" id="3372714"/>
    <dbReference type="KEGG" id="cpv:cgd4_230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_230"/>
    <dbReference type="InParanoid" id="Q5CQL6"/>
    <dbReference type="OMA" id="RNNIRNC"/>
    <dbReference type="OrthoDB" id="340659at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87693.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="437" mass="51622" checksum="33BE22EF7AFD58B7" modified="2005-04-12" version="1">MNLNYLEVYFFQAVFIFVIFFGLALSENIDEYKEIENYNNTSDDVIGNNRGQIIMEEVENMIKRLQVDTNLTFDSEKLDNKTEITREITEEDIKKVVEKEKMEKNKILTEMFETLLDHEFDSNLTRNNKFESLTPLKKGEEISNVIIDENFLSKLNDLDWQITMEKMHNTIWYYWDNEIHKEYVQRIPSALRQLRQISQKMGVSSLFDEGELGDTINKLNNKSKTADRKYKKLFKKLFVNDFNQNIPEIKYKRSEEAMINMVIELKGYIRILLKLIDIKASQVGLLLLNKVQRKSFKKLSTNLNLFRSNIKSCPVHTAFSYRYQDENFDILMHHEKGFGIWNTRDLSNIDRKKSIEISREIDEMINFVHNEFIAPIALLGSSIEDTALIHSSLVRNLWKNITVQNKIPLYVIFESISKATFFFIKQINNKIYMVNNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQP0</accession>
    <name>Q5CQP0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large protein with signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87743.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625962.1">
        <property type="nucleotide sequence ID" value="XM_625962.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372915"/>
    <dbReference type="KEGG" id="cpv:cgd4_3870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3870"/>
    <dbReference type="InParanoid" id="Q5CQP0"/>
    <dbReference type="OMA" id="QMESSRI"/>
    <dbReference type="OrthoDB" id="342259at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87743.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2068" mass="242144" checksum="800DDC7E678318B4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQV3</accession>
    <name>Q5CQV3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cullin-like protein of probable plant origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd4_3150</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2 3">Belongs to the cullin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87800.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625899.1">
        <property type="nucleotide sequence ID" value="XM_625899.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQV3"/>
    <dbReference type="FunCoup" id="Q5CQV3">
        <property type="interactions" value="247"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQV3"/>
    <dbReference type="GeneID" id="3372788"/>
    <dbReference type="KEGG" id="cpv:cgd4_3150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3150"/>
    <dbReference type="InParanoid" id="Q5CQV3"/>
    <dbReference type="OMA" id="IREWDRY"/>
    <dbReference type="OrthoDB" id="27073at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1310.10">
        <property type="entry name" value="Cullin Repeats"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.130">
        <property type="entry name" value="Cullin, Chain C, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045093">
        <property type="entry name" value="Cullin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059120">
        <property type="entry name" value="Cullin-like_AB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016158">
        <property type="entry name" value="Cullin_homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036317">
        <property type="entry name" value="Cullin_homology_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001373">
        <property type="entry name" value="Cullin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019559">
        <property type="entry name" value="Cullin_neddylation_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016159">
        <property type="entry name" value="Cullin_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11932">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00888">
        <property type="entry name" value="Cullin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26557">
        <property type="entry name" value="Cullin_AB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10557">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00182">
        <property type="entry name" value="CULLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00884">
        <property type="entry name" value="Cullin_Nedd8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75632">
        <property type="entry name" value="Cullin homology domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF74788">
        <property type="entry name" value="Cullin repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50069">
        <property type="entry name" value="CULLIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cullin family profile" evidence="4">
        <location>
            <begin position="434"/>
            <end position="702"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87800.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="826" mass="96447" checksum="6BBE71C68F7CFA07" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQX1</accession>
    <name>Q5CQX1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ERCC4/XP-G-type excision repair nuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd4_2960</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625881.1">
        <property type="nucleotide sequence ID" value="XM_625881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQX1"/>
    <dbReference type="STRING" id="353152.Q5CQX1"/>
    <dbReference type="GeneID" id="3372971"/>
    <dbReference type="KEGG" id="cpv:cgd4_2960"/>
    <dbReference type="InParanoid" id="Q5CQX1"/>
    <dbReference type="OMA" id="HEGYSEN"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20078">
        <property type="entry name" value="XPF_nuclease_XPF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10130:FF:000002">
        <property type="entry name" value="DNA repair endonuclease XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010994">
        <property type="entry name" value="RuvA_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047520">
        <property type="entry name" value="XPF_nuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47781">
        <property type="entry name" value="RuvA domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="10">
        <location>
            <begin position="58"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="308" mass="35380" checksum="419BBC66731C1EB1" modified="2005-04-12" version="1" fragment="single">EKLLNAIKSEELSWIGLERHKKTLVVPLSDITEGEILAKLSNSSIYQDRYKEENDIQKIIVDIREFRSSLPYQLFCKGVKIIPMSLEIGDYVISRDVCIERKSLPDLVNSLSNGRLFTQLQWISKHYSTPVILIELNSLIEILNHQGMQQNFLPMKFNSCDIYLKLILLTRHFPNIKFIWSCNSSFSSLVILRIKKDREQPNLKDASTLNTGILKANDISIEKEKKSKGKKRKVSSDSTKSNYYATAFLRYLPGINAKNIKVLTSNFRSIKEIINTPLENLINHLGISFGTSLFRALHEGYSENINLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQY8</accession>
    <name>Q5CQY8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Putative ethanolaminephosphotransferase (ETHPT) 9 transmembrane domain protein involved in lipid metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_2790</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the CDP-alcohol phosphatidyltransferase class-I family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625864.1">
        <property type="nucleotide sequence ID" value="XM_625864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQY8"/>
    <dbReference type="FunCoup" id="Q5CQY8">
        <property type="interactions" value="76"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQY8"/>
    <dbReference type="GeneID" id="3373004"/>
    <dbReference type="KEGG" id="cpv:cgd4_2790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2790"/>
    <dbReference type="InParanoid" id="Q5CQY8"/>
    <dbReference type="OMA" id="SVYANCK"/>
    <dbReference type="OrthoDB" id="196717at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016780">
        <property type="term" value="F:phosphotransferase activity, for other substituted phosphate groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008654">
        <property type="term" value="P:phospholipid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1760">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000462">
        <property type="entry name" value="CDP-OH_P_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043130">
        <property type="entry name" value="CDP-OH_PTrfase_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048254">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014472">
        <property type="entry name" value="CHOPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414:SF37">
        <property type="entry name" value="BB IN A BOXCAR, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10414">
        <property type="entry name" value="ETHANOLAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01066">
        <property type="entry name" value="CDP-OH_P_transf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015665">
        <property type="entry name" value="CHOPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00379">
        <property type="entry name" value="CDP_ALCOHOL_P_TRANSF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5 7" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="59"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="90"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="259"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="285"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="316"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="346"/>
            <end position="367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="428" mass="48328" checksum="644B4E7C3196323B" modified="2005-04-12" version="1">MASSSKEKITHVGVFGSFISEVGLKNIKEYSYKSGGVTFLDYAMNPFWEFFAHQIPECISPNLLTIFGFLCSLIAMLLTMMTCPMLDNAIPLNLSLFISLLLFLYQTFDAADGKHARRLKISSPLGQLLDHGLDSYTTIFFSTIFCACCKMGWSYKFFIFLSIVQFKMFSFIWLECHCKIFRCSSSDYLGVTESQLIVMFFTVYSSTNGFNILFKNLLFNISTIDLIILSIIATGFITLINDILSGLDECRSTTSKKVASLEICGVLCHLTFQFLFLSSGTYKKFPIMTMFILTTSSSIVALRMNVSSFTLEELPYVHWPALPFYTSSVFLLFGRNIFGKFFDSQIILLIVALWNVIYTIDYVSIIINSICHHLSISLISTKISNGDSAEKNTSDKATANNFSNNRAEDISSKLKLSISRSFKKNHRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR04</accession>
    <name>Q5CR04_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_2620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87841.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625848.1">
        <property type="nucleotide sequence ID" value="XM_625848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR04"/>
    <dbReference type="STRING" id="353152.Q5CR04"/>
    <dbReference type="GeneID" id="3372848"/>
    <dbReference type="KEGG" id="cpv:cgd4_2620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2620"/>
    <dbReference type="InParanoid" id="Q5CR04"/>
    <dbReference type="OrthoDB" id="342255at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87841.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="324" mass="38263" checksum="849BC63C6F05D1CC" modified="2005-04-12" version="1">MSESLENNDAYIFKSNQRKNFNDMIKIFRGKILSKSDQLNNKRNSINCTSSTKKVNEKFVFENSDINDDKDSHINIAHLSNRLQLRSMKNEFEGGEIINLKRIFNYSRPNKNFFRRKKSEEKLEIQEKKLTSKDLFERIESARDMGRERIKRANLYYNKLLSYVKYYAVDEASEFIINDLSRREIYLLVEHDFKHIFSNDFQEKSLQEVYSQVRSKIHDSAINNKGIPLMFEEILDEKLFETKEPEEDFNFDFLDSFSNLRLQGDENLNVFLNSIGTSSAFVEFSIEYLLSRTCNVSLEVNRTVVDCIKKDIIDINTGIYKKGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR38</accession>
    <name>Q5CR38_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_2240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87867.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625814.1">
        <property type="nucleotide sequence ID" value="XM_625814.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372949"/>
    <dbReference type="KEGG" id="cpv:cgd4_2240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2240"/>
    <dbReference type="InParanoid" id="Q5CR38"/>
    <dbReference type="OMA" id="HESSTNC"/>
    <dbReference type="OrthoDB" id="341418at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87867.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1321" mass="151585" checksum="369952329EA8B796" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRA6</accession>
    <name>Q5CRA6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88046.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626280.1">
        <property type="nucleotide sequence ID" value="XM_626280.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373104"/>
    <dbReference type="KEGG" id="cpv:cgd5_3570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3570"/>
    <dbReference type="InParanoid" id="Q5CRA6"/>
    <dbReference type="OMA" id="CYINIFA"/>
    <dbReference type="OrthoDB" id="340098at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253766" evidence="1">
        <location>
            <begin position="20"/>
            <end position="1490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88046.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1490" mass="165525" checksum="6CB5FF4D34A21D32" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRE5</accession>
    <name>Q5CRE5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Midasin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd5_3110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the midasin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88015.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626241.1">
        <property type="nucleotide sequence ID" value="XM_626241.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRE5"/>
    <dbReference type="GeneID" id="3373253"/>
    <dbReference type="KEGG" id="cpv:cgd5_3110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3110"/>
    <dbReference type="InParanoid" id="Q5CRE5"/>
    <dbReference type="OrthoDB" id="5186at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000142">
        <property type="entry name" value="Midasin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040848">
        <property type="entry name" value="AAA_lid_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011704">
        <property type="entry name" value="ATPase_dyneun-rel_AAA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041190">
        <property type="entry name" value="Midasin_AAA_lid_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025662">
        <property type="entry name" value="Sigma_54_int_dom_ATP-bd_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103:SF2">
        <property type="entry name" value="MIDASIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48103">
        <property type="entry name" value="MIDASIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07728">
        <property type="entry name" value="AAA_5"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17865">
        <property type="entry name" value="AAA_lid_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17867">
        <property type="entry name" value="AAA_lid_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00675">
        <property type="entry name" value="SIGMA54_INTERACT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0143">Chaperone</keyword>
    <keyword evidence="9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="777"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="1381"/>
            <end position="1527"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="1732"/>
            <end position="2020"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="10">
        <location>
            <begin position="2368"/>
            <end position="2539"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="1786"/>
            <end position="1841"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00017143"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88015.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2893" mass="338111" checksum="7D51CD0AA9390616" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRL4</accession>
    <name>Q5CRL4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">SnRNP assembly defective 1 like ubiquitin C-terminal hydrolase with a UBP finger at the N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd5_2350</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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        <property type="protein sequence ID" value="EAK87961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_626172.1"/>
    </dbReference>
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    <dbReference type="FunCoup" id="Q5CRL4">
        <property type="interactions" value="468"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRL4"/>
    <dbReference type="MEROPS" id="C19.972"/>
    <dbReference type="GeneID" id="3373124"/>
    <dbReference type="KEGG" id="cpv:cgd5_2350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2350"/>
    <dbReference type="InParanoid" id="Q5CRL4"/>
    <dbReference type="OMA" id="QLRRFKC"/>
    <dbReference type="OrthoDB" id="10263353at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
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    </dbReference>
    <dbReference type="InterPro" id="IPR050185">
        <property type="entry name" value="Ub_carboxyl-term_hydrolase"/>
    </dbReference>
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        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033809">
        <property type="entry name" value="USP39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001607">
        <property type="entry name" value="Znf_UBP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646:SF16">
        <property type="entry name" value="U4_U6.U5 TRI-SNRNP-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21646">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02148">
        <property type="entry name" value="zf-UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00290">
        <property type="entry name" value="ZnF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50271">
        <property type="entry name" value="ZF_UBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBP-type" evidence="11">
        <location>
            <begin position="10"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="10">
        <location>
            <begin position="130"/>
            <end position="495"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK87961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="498" mass="56972" checksum="CBCA3B25CD5346C7" modified="2005-04-12" version="1">MGDHSEKDGERCPYLSSIKRSVLDFDYEKICSVTLREEHIYCCLVCGINYQGKGKGSMAYKHSLELKHHLFINLTNSSIICLPNDYEIYEHSLEDIKGYLQPRFNSEIISSSLYDVSRTFDGIEFSPGFIGLSNFGNNDSLNSIILILSRITEFRDLCLSYQLYSKEIEKRIPDPLLFSIIESIQKIYNPNNLKGKFSPYNLVKIIEKKSNGKFSFSKISNISTSSNSFIQSNVGTQNSTIIDPMALFSWITYNLKKKIDKYLRKFQIKFIPDIDKNTNKSNMNIFDVCIKGELYNKASKYPNNKKSESSTDNLMKSKKCSELKSTASICFNCLSLTLPSIIETTMGISNSAQSNEDKTISQIPIYQLLDSKFFSSSSSSQLISKLPYYLFIHFSRFSKANLNLEKNKTLVSFPLIDLDLSSYIHPDYISLNPCTKYNLIANISHKGTIQSGKFLTQLLHPTRNEWIEIEDINVKVVLPQEILLNETYIIVYKRSDLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRN4</accession>
    <name>Q5CRN4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Chromatin associated proein with a chromodomain at the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2130</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88057.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626152.1">
        <property type="nucleotide sequence ID" value="XM_626152.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRN4"/>
    <dbReference type="GeneID" id="3373115"/>
    <dbReference type="KEGG" id="cpv:cgd5_2130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2130"/>
    <dbReference type="InParanoid" id="Q5CRN4"/>
    <dbReference type="OMA" id="SENKESC"/>
    <dbReference type="OrthoDB" id="340605at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00024">
        <property type="entry name" value="CD_CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="Chromo-like_dom_sf"/>
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        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
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        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
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        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
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        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50013">
        <property type="entry name" value="CHROMO_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromo" evidence="2">
        <location>
            <begin position="1002"/>
            <end position="1064"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="786"/>
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        </location>
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        <location>
            <begin position="889"/>
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        </location>
    </feature>
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        <location>
            <begin position="28"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="791"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="818"/>
            <end position="834"/>
        </location>
    </feature>
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        <location>
            <begin position="903"/>
            <end position="915"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="916"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="959"/>
            <end position="969"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50013"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88057.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1075" mass="120131" checksum="0FE09C46B827F592" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRS6</accession>
    <name>Q5CRS6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_1660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626110.1">
        <property type="nucleotide sequence ID" value="XM_626110.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRS6"/>
    <dbReference type="GeneID" id="3373016"/>
    <dbReference type="KEGG" id="cpv:cgd5_1660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1660"/>
    <dbReference type="InParanoid" id="Q5CRS6"/>
    <dbReference type="OrthoDB" id="343460at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254170" evidence="2">
        <location>
            <begin position="20"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="119"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="195"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="316" mass="35368" checksum="4346D2FCD4E97266" modified="2005-04-12" version="1">MKFFVSIKLLFCYIYLVAAINGTKRKRKSIGLVFRKSSYTDSFCSLLGCKDGKGYASSGDGECYSVTRCTKCKKTNVSESSMAYCSAIPTIPNELTLFQGFLKTSKSGQEILNSSVFMDESSDMSENDEQKTDDSEGSQDYDDNDDDDDDDDDDDDDSDRENAAGINRGYPSKHISMSTSNLNGKSEYSLLELVSQMTESESEEENENLSNLPKSNKSRSKGLFGRIFSKKKKNKPDENQATQFKKTNRFSFNLNSLKNKFRDKNGPNKLNLSSKEFDKSTVNQKLKSAQISKGTIIEWEASGSILNERLNKCTVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS55</accession>
    <name>Q5CS55_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625981.1">
        <property type="nucleotide sequence ID" value="XM_625981.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373199"/>
    <dbReference type="KEGG" id="cpv:cgd5_170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_170"/>
    <dbReference type="InParanoid" id="Q5CS55"/>
    <dbReference type="OMA" id="WIAWERE"/>
    <dbReference type="OrthoDB" id="337624at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1285" mass="151639" checksum="3EBDE30500A11A74" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSJ1</accession>
    <name>Q5CSJ1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Signal recognition particle subunit SRP68</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_2500</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SRP68 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628076.1">
        <property type="nucleotide sequence ID" value="XM_628076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSJ1"/>
    <dbReference type="STRING" id="353152.Q5CSJ1"/>
    <dbReference type="GeneID" id="3371700"/>
    <dbReference type="KEGG" id="cpv:cgd1_2500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2500"/>
    <dbReference type="InParanoid" id="Q5CSJ1"/>
    <dbReference type="OMA" id="DERFIHI"/>
    <dbReference type="OrthoDB" id="10255118at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030942">
        <property type="term" value="F:endoplasmic reticulum signal peptide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005047">
        <property type="term" value="F:signal recognition particle binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006614">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd15481">
        <property type="entry name" value="SRP68-RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3450.40">
        <property type="entry name" value="Signal recognition particle, SRP68 subunit, RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026258">
        <property type="entry name" value="SRP68"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034652">
        <property type="entry name" value="SRP68-RBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038253">
        <property type="entry name" value="SRP68_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 68 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12860:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE SUBUNIT SRP68"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16969">
        <property type="entry name" value="SRP68"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6" id="KW-0733">Signal recognition particle</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00029498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="632" mass="73253" checksum="A15639FAB839257D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSL9</accession>
    <name>Q5CSL9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PI31 proteasome regulator N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_2140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628048.1">
        <property type="nucleotide sequence ID" value="XM_628048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSL9"/>
    <dbReference type="GeneID" id="3371683"/>
    <dbReference type="KEGG" id="cpv:cgd1_2140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2140"/>
    <dbReference type="InParanoid" id="Q5CSL9"/>
    <dbReference type="OMA" id="AWDENFR"/>
    <dbReference type="OrthoDB" id="340763at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="32120" checksum="5200D91BB668C57B" modified="2005-04-12" version="1">MDRSFWIHILFKHANPEDLYENVLVITHSILLDLGFIPVKSIKGEDDEIDNTLDHTCISEEFGVPINSRDDSISMELLPSNWRSKSKKNRLFYISKICSKKIEKVIPELIFDLNSSETSVQLSVKSNLIGEAMKLEFPFKISENYSSNESLMFELSGLIRNEIDGFFNRNKIYNNNSKINIEEGHKIPIIKCEPLLETERSFEEYIGNNFRKSVDPLIDSNGVRGSLVGPESIIFKNQPKIFGKPKNIPISSIPGGTTIPDNDMFFPPGNNNSNYMFNFRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSR5</accession>
    <name>Q5CSR5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RPB7 like OB fold RNA polymerase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_1620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628002.1">
        <property type="nucleotide sequence ID" value="XM_628002.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSR5"/>
    <dbReference type="STRING" id="353152.Q5CSR5"/>
    <dbReference type="GeneID" id="3371646"/>
    <dbReference type="KEGG" id="cpv:cgd1_1620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1620"/>
    <dbReference type="InParanoid" id="Q5CSR5"/>
    <dbReference type="OMA" id="AQNPWYV"/>
    <dbReference type="OrthoDB" id="10250504at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04328">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041901">
        <property type="entry name" value="RNAP_I_Rpa43_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="256" mass="29219" checksum="4A44C94E578758F4" modified="2005-04-12" version="1">MYQIPWVVKESCVVTNEVAYHLIGKCIRNLAKLGKSEFEENPSSMQETVREVEKLSTEQLQNIRESFINKGEYDNECFELLRVKGTVQLLPNSIGNIEDSIKKYLCCFLFHYIAEFQGVWICFHKISTVNTYGYVPDCEPNGSFLVNVEFKALVFKPKIGELLICRISHVSPSHVSGITYGILNVVIPMKSFKGDEYEFQKADSLTYETNTLVNKINKEKNLKVGSIIFVRIKKYSFSDNGDFISSISGQFESLID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CST6</accession>
    <name>Q5CST6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_1390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627981.1">
        <property type="nucleotide sequence ID" value="XM_627981.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CST6"/>
    <dbReference type="GeneID" id="3371624"/>
    <dbReference type="KEGG" id="cpv:cgd1_1390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1390"/>
    <dbReference type="InParanoid" id="Q5CST6"/>
    <dbReference type="OMA" id="TIQKEAM"/>
    <dbReference type="OrthoDB" id="339185at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="463" mass="53450" checksum="060B5DB43AA0A79D" modified="2005-04-12" version="1">MLNKDTSNSLKIPEYCFRRRNFKGEGELENSKLHAFTDECWDSPRITPNFGDENDSLLPNRTLSRVPRIYSLAEGDFEDFENKPEAHKPLFDAARESSSIDSEITIHAEEYTKPANDGYDYDDDYYDDDDEALTPLASSAARYRLYDIDWDEKSRLKKDEQISNIHEIQDDIKLKDSDFCLLDSTGIKGPKEFETKQGKVIISEDGDFSFEFSDRRKLFTVKGGGCFVLVSDVIDKKRRVSDDSSFESADVTNQEYNESKYHVSELPQQHLKRYIYGTHLCETIKSFIPKVKLKVPQEGTYFLMSNHLTFADFRAEFISNLSGQVLSAHLTNYQSTVIFTSKSGKRVEFDKLILDKMGVFEEVDQAFEEIKYNDYLIKKSHEVSECGIEWSTIIKIWRLILDRLVDCKNLELKGLKAYSESLISSDVDLTLSESFSIGGNCMMDWHIKKSVFENIFPIQVEKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSV3</accession>
    <name>Q5CSV3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_1200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627964.1">
        <property type="nucleotide sequence ID" value="XM_627964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSV3"/>
    <dbReference type="GeneID" id="3371601"/>
    <dbReference type="KEGG" id="cpv:cgd1_1200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1200"/>
    <dbReference type="InParanoid" id="Q5CSV3"/>
    <dbReference type="OMA" id="ERIEFNT"/>
    <dbReference type="OrthoDB" id="343031at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="307" mass="34920" checksum="295C7D8ED2164780" modified="2005-04-12" version="1">MKGEVSLIEKKHITGGNDEYVSAVEVKKTAQQQSEAAKDIMSCSNLNIYYPIQTTQRKSNEIDSEGFCFEKNQYPSSTRVLSELDDCTEESFESLSGVGKTCNKTISRKESLECIEWSGEERVFSPETKFPLSKIEFYSNWKNIINHQDAPRTPQFRATYILPTSPHFSDSDEFYSDSSSNSSESLLYIQKETPIMRKNNNAFKTNSRRVNGISWNQYEGANEVNYNCISPSLPIPSSIQGRNRLDILLSQWVSYFSGRQSIDINDIDYATQYFTGLDGATLAAVTSSLIYIGHCARYTQIRKYNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSY4</accession>
    <name>Q5CSY4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mnd1 HTH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88584.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627933.1">
        <property type="nucleotide sequence ID" value="XM_627933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSY4"/>
    <dbReference type="STRING" id="353152.Q5CSY4"/>
    <dbReference type="GeneID" id="3371372"/>
    <dbReference type="KEGG" id="cpv:cgd1_840"/>
    <dbReference type="InParanoid" id="Q5CSY4"/>
    <dbReference type="OMA" id="GNDHVYM"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040453">
        <property type="entry name" value="Mnd1_HTH"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03962">
        <property type="entry name" value="Mnd1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Mnd1 HTH" evidence="1">
        <location>
            <begin position="1"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF03962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88584.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="66" mass="7472" checksum="1CD1445CD721DD57" modified="2005-04-12" version="1" fragment="single">KECFNLKEIEKLGKKCGIIEQTVKDVLQSLVDDSLVVSDKIGSLNIFWALPSAAKFSKENRLEYLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT28</accession>
    <name>Q5CT28_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="2">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd1_290</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627889.1">
        <property type="nucleotide sequence ID" value="XM_627889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT28"/>
    <dbReference type="FunCoup" id="Q5CT28">
        <property type="interactions" value="585"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT28"/>
    <dbReference type="GeneID" id="3371382"/>
    <dbReference type="KEGG" id="cpv:cgd1_290"/>
    <dbReference type="InParanoid" id="Q5CT28"/>
    <dbReference type="OMA" id="FKSDAEY"/>
    <dbReference type="OrthoDB" id="333239at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061136">
        <property type="term" value="P:regulation of proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02657">
        <property type="entry name" value="Peptidase_C19A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044635">
        <property type="entry name" value="UBP14-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43982:SF1">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="15"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="124"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="499" mass="56680" checksum="78F063B08E93A9A4" modified="2005-04-12" version="1" fragment="single">TQVIINIKLNAMEQIKVTVKWNVKTFEDVDLVFSSPLSEFRERLSNLTGVPASKQKLMSQRGVLRDGMDLNKLGLKPGSKIVLVGTAEGGELKAPSEKTIFFEDLTSDERAKILHEKEIVPLPVGLENLGNTCYLNSIIHMLRSIPSFLQILRNSNLSSSERTSSSSGNSIKFLNSFKQLMDKMDGSIERVVPGECVDLFRRQFPQYSTTTGGAFAMYQQQDAEEVLGSLLTLFRNELDGKDGDDQTIGDIFRFRMKTKFKNTALETDEEVKMEENYKLMCHMGTQLNPVDFLTQGIKLSLDEKVEKKSSETGIDSIYQKTSEIDSLPPYLLVQLVRFEWKKSSEIARTEATRAKVCRKIEFSQNLDLYEFCSEDLKKILNIGRDISEKKKSKAIEKPDQEEQKMETELYTDCPTGVYELECVVTHQGRTADSGHYVAWRYCPNDREYIIKFDDDKVSRIKAKDADLSGGRSDYHIAVMLLYKKTVIKASEEEMATLLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT36</accession>
    <name>Q5CT36_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Narf-like protein nuclear prelamin A recognition factor</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NARF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627881.1">
        <property type="nucleotide sequence ID" value="XM_627881.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT36"/>
    <dbReference type="FunCoup" id="Q5CT36">
        <property type="interactions" value="66"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT36"/>
    <dbReference type="GeneID" id="3371428"/>
    <dbReference type="KEGG" id="cpv:cgd1_190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_190"/>
    <dbReference type="InParanoid" id="Q5CT36"/>
    <dbReference type="OMA" id="GYLHHVL"/>
    <dbReference type="OrthoDB" id="10253113at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1780">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.950.10">
        <property type="entry name" value="Fe-only Hydrogenase (Larger Subunit), Chain L, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050340">
        <property type="entry name" value="Cytosolic_Fe-S_CAF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009016">
        <property type="entry name" value="Fe_hydrogenase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004108">
        <property type="entry name" value="Fe_hydrogenase_lsu_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11615">
        <property type="entry name" value="NITRATE, FORMATE, IRON DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02906">
        <property type="entry name" value="Fe_hyd_lg_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53920">
        <property type="entry name" value="Fe-only hydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="2">
        <location>
            <begin position="99"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Iron hydrogenase large subunit C-terminal" evidence="2">
        <location>
            <begin position="235"/>
            <end position="463"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="560" mass="63091" checksum="F3A3B18F9A4C4F7B" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT93</accession>
    <name>Q5CT93_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted fatty acid binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_3940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626576.1">
        <property type="nucleotide sequence ID" value="XM_626576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT93"/>
    <dbReference type="GeneID" id="3373398"/>
    <dbReference type="KEGG" id="cpv:cgd2_3940"/>
    <dbReference type="InParanoid" id="Q5CT93"/>
    <dbReference type="OrthoDB" id="354351at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="124" mass="14598" checksum="ABA7CBC14A2BC525" modified="2005-04-12" version="1">MEQFLQKIGVGMLKRKVINKGSYTLKVEISNEKLLVIKIEPFFGPTQILNWDLSGEIFIEKNPEVGIWRNRVEFIEFKHEKTNNQLVTAICMTRESENLPGKVIETRWTQPGDENTKIKFIRYR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT94</accession>
    <name>Q5CT94_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">eIF4G eukaryotic initiation factor 4, Nic domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_3920</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626575.1">
        <property type="nucleotide sequence ID" value="XM_626575.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT94"/>
    <dbReference type="STRING" id="353152.Q5CT94"/>
    <dbReference type="GeneID" id="3373399"/>
    <dbReference type="KEGG" id="cpv:cgd2_3920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3920"/>
    <dbReference type="InParanoid" id="Q5CT94"/>
    <dbReference type="OMA" id="FYYFNVP"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="938"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="540"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="852"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="24"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="99"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="138"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="173"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="217"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="234"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="259"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="292"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="346"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="394"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="462"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="543"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="571"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="600"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="616"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="687"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="742"/>
            <end position="772"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="774"/>
            <end position="785"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="788"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="852"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="872"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1235" mass="137607" checksum="C8FCA14EFFA9DC9F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTE0</accession>
    <name>Q5CTE0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_3390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626529.1">
        <property type="nucleotide sequence ID" value="XM_626529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTE0"/>
    <dbReference type="GeneID" id="3373760"/>
    <dbReference type="KEGG" id="cpv:cgd2_3390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3390"/>
    <dbReference type="InParanoid" id="Q5CTE0"/>
    <dbReference type="OMA" id="IIETCST"/>
    <dbReference type="OrthoDB" id="338403at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="164" mass="18582" checksum="B01AE846D67BB71E" modified="2005-04-12" version="1">MYLEKESLHLLNGSFFRVNFKAISQGELKNILKACGLKSSTNTSSNQQIALLEGIRRYLLTEDLSELTDLSNPNIKSIESKRYTFDYKNIINEDTISLELILKSLRRSPLTLEKIMMSNSVSVSEIAECCSSYLNTPKSVFLNKIILDKIQLVLDSLKIKNIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTF9</accession>
    <name>Q5CTF9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Tbc domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_3170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88698.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626510.1">
        <property type="nucleotide sequence ID" value="XM_626510.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTF9"/>
    <dbReference type="STRING" id="353152.Q5CTF9"/>
    <dbReference type="GeneID" id="3373558"/>
    <dbReference type="KEGG" id="cpv:cgd2_3170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3170"/>
    <dbReference type="InParanoid" id="Q5CTF9"/>
    <dbReference type="OMA" id="DANFSLY"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="99"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88698.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="678" mass="78493" checksum="151611CE10EBE4BF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTJ6</accession>
    <name>Q5CTJ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">ARM repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626473.1">
        <property type="nucleotide sequence ID" value="XM_626473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTJ6"/>
    <dbReference type="GeneID" id="3373630"/>
    <dbReference type="KEGG" id="cpv:cgd2_2720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2720"/>
    <dbReference type="InParanoid" id="Q5CTJ6"/>
    <dbReference type="OMA" id="AKWSGYE"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1003" mass="115921" checksum="D8832F5A43D799CF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTQ6</accession>
    <name>Q5CTQ6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">General transcription factor IIH subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd2_2060</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TFB2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88784.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626413.1">
        <property type="nucleotide sequence ID" value="XM_626413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTQ6"/>
    <dbReference type="FunCoup" id="Q5CTQ6">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTQ6"/>
    <dbReference type="GeneID" id="3373528"/>
    <dbReference type="KEGG" id="cpv:cgd2_2060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2060"/>
    <dbReference type="InParanoid" id="Q5CTQ6"/>
    <dbReference type="OMA" id="RRQLKMW"/>
    <dbReference type="OrthoDB" id="364513at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2610">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040662">
        <property type="entry name" value="Tfb2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004598">
        <property type="entry name" value="TFIIH_p52/Tfb2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152:SF0">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13152">
        <property type="entry name" value="TFIIH, POLYPEPTIDE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03849">
        <property type="entry name" value="Tfb2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18307">
        <property type="entry name" value="Tfb2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0227">DNA damage</keyword>
    <keyword evidence="6 8" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 8" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="Transcription factor Tfb2 C-terminal" evidence="9">
        <location>
            <begin position="616"/>
            <end position="701"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF18307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88784.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="709" mass="81387" checksum="EE829E6219CD0CBE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTR2</accession>
    <name>Q5CTR2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apicomplexan protein with signal peptide and 3 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_2000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626407.1">
        <property type="nucleotide sequence ID" value="XM_626407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTR2"/>
    <dbReference type="GeneID" id="3373533"/>
    <dbReference type="KEGG" id="cpv:cgd2_2000"/>
    <dbReference type="InParanoid" id="Q5CTR2"/>
    <dbReference type="OMA" id="AKHRIMI"/>
    <dbReference type="OrthoDB" id="423534at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="68"/>
            <end position="94"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="186" mass="20812" checksum="BB6E2A401622893E" modified="2005-04-12" version="1">MINSLFQLLFGILLMILDVPGSPRWSARGRALIRKEARFLTHLTGKSLCLLFLSCLTSTTLWPQRRGAGVLALLAFLTSIAVAGVAIIGLLISLQKSVRLERVRKNIITTKTSTVADVYRRYAIADPVYGMQFEEFSRMAADYTNGRQQFGVTDLSIIYNALDENQKSGINEREFSEWVNGSTVYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTS1</accession>
    <name>Q5CTS1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_1790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88799.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626398.1">
        <property type="nucleotide sequence ID" value="XM_626398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTS1"/>
    <dbReference type="GeneID" id="3373740"/>
    <dbReference type="KEGG" id="cpv:cgd2_1790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1790"/>
    <dbReference type="InParanoid" id="Q5CTS1"/>
    <dbReference type="OMA" id="KCISITI"/>
    <dbReference type="OrthoDB" id="361362at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88799.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1039" mass="122223" checksum="C04FFB59E55666EA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTT6</accession>
    <name>Q5CTT6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_1620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88810.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626383.1">
        <property type="nucleotide sequence ID" value="XM_626383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTT6"/>
    <dbReference type="GeneID" id="3373712"/>
    <dbReference type="KEGG" id="cpv:cgd2_1620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1620"/>
    <dbReference type="InParanoid" id="Q5CTT6"/>
    <dbReference type="OrthoDB" id="342883at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="111"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="218"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88810.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="252" mass="29079" checksum="1D56D8F23AEA4406" modified="2005-04-12" version="1">MNINKNEVSLSPLNSLSTQLDSNTNKENHFDVKNQKPQCISDNTEANIKHEDFEKSNIKKKYKKNLIWDGPRWDLAHFDPTMSARERKKLVYYEALFNKLENDVVLRCNEHNNKNVKNPNQKRKMRNNTLDSSPKTELSDLKGMKEHKSDIDSGDSSKSDNYSKANQEKFVNSHNSNQIGILLTPDRSFSRSENIISPILEEPRKCSRSNANSQTPANERENSSIRRSNDWRVKLLNKRCSLQATPYRGATP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTZ2</accession>
    <name>Q5CTZ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626327.1">
        <property type="nucleotide sequence ID" value="XM_626327.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTZ2"/>
    <dbReference type="GeneID" id="3373601"/>
    <dbReference type="KEGG" id="cpv:cgd2_960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_960"/>
    <dbReference type="InParanoid" id="Q5CTZ2"/>
    <dbReference type="OMA" id="PINNDIP"/>
    <dbReference type="OrthoDB" id="341549at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="72"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="345"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="360"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="610" mass="70029" checksum="6E780567946D534D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTZ5</accession>
    <name>Q5CTZ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Peptidase'insulinase-like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_930</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626324.1">
        <property type="nucleotide sequence ID" value="XM_626324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTZ5"/>
    <dbReference type="SMR" id="Q5CTZ5"/>
    <dbReference type="STRING" id="353152.Q5CTZ5"/>
    <dbReference type="GeneID" id="3373604"/>
    <dbReference type="KEGG" id="cpv:cgd2_930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_930"/>
    <dbReference type="InParanoid" id="Q5CTZ5"/>
    <dbReference type="OMA" id="INQVMEH"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043171">
        <property type="term" value="P:peptide catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000012">
        <property type="entry name" value="Protease 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032632">
        <property type="entry name" value="Peptidase_M16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054734">
        <property type="entry name" value="PqqF-like_C_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16187">
        <property type="entry name" value="Peptidase_M16_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22456">
        <property type="entry name" value="PqqF-like_C_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="9">
        <location>
            <begin position="35"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="10">
        <location>
            <begin position="200"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 middle/third" evidence="11">
        <location>
            <begin position="394"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="domain" description="Coenzyme PQQ synthesis protein F-like C-terminal lobe" evidence="12">
        <location>
            <begin position="825"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF22456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1013" mass="116229" checksum="37E2ECC5D8D52A95" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU04</accession>
    <name>Q5CU04_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative translation initiation factor 1 (eIF1), SUI1p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_820</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SUI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626315.1">
        <property type="nucleotide sequence ID" value="XM_626315.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU04"/>
    <dbReference type="FunCoup" id="Q5CU04">
        <property type="interactions" value="389"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU04"/>
    <dbReference type="GeneID" id="3373609"/>
    <dbReference type="KEGG" id="cpv:cgd2_820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_820"/>
    <dbReference type="InParanoid" id="Q5CU04"/>
    <dbReference type="OMA" id="VENHIHI"/>
    <dbReference type="OrthoDB" id="10248435at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11566">
        <property type="entry name" value="eIF1_SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005874">
        <property type="entry name" value="SUI1_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10388">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004499">
        <property type="entry name" value="SUI1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="30"/>
            <end position="100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="112" mass="12199" checksum="613A8F5C3675FFAC" modified="2005-04-12" version="1">MASSSDTVGIPTPFVVDALSEVGKSSSGYVHIRNQQRNGKKSLTTVQGLSAEFDLKRLLKAFKKNFSCNGTIIDDPEHGPILQIQGDHRHNVARFLVGENIVNSDEIKIHGA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU69</accession>
    <name>Q5CU69_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_4010</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626945.1">
        <property type="nucleotide sequence ID" value="XM_626945.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU69"/>
    <dbReference type="FunCoup" id="Q5CU69">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU69"/>
    <dbReference type="GeneID" id="3373902"/>
    <dbReference type="KEGG" id="cpv:cgd3_4010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4010"/>
    <dbReference type="InParanoid" id="Q5CU69"/>
    <dbReference type="OMA" id="YGWDQSA"/>
    <dbReference type="OrthoDB" id="164025at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044548">
        <property type="term" value="F:S100 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031625">
        <property type="term" value="F:ubiquitin protein ligase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06468">
        <property type="entry name" value="p23_CacyBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052289">
        <property type="entry name" value="Calcyclin-binding_UBL-bridge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037893">
        <property type="entry name" value="CS_CacyBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007699">
        <property type="entry name" value="SGS_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164:SF3">
        <property type="entry name" value="CALCYCLIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13164">
        <property type="entry name" value="CALICYLIN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51048">
        <property type="entry name" value="SGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="3">
        <location>
            <begin position="82"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="SGS" evidence="2">
        <location>
            <begin position="158"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="245" mass="27793" checksum="DE8327A7E9D5FB13" modified="2005-04-12" version="1">MSNLSIIQGDLNELKALKTQCKRDGVKMILSNQIRLLEEKQRNMCISDAGRKNLEYNQLNVNNVPESISKKQNENLPLEAYTSITKYSWDQSDKSVKIYIDLVGVQDKPDCIEIKFGKDNVEMYVKNLDNKFYSFTVKLHDTISPEECSHKVKKDMIVITLKKANNSSKWPRLSYKDSPLKKTSATSDPSSGMGNFGDMGGAGMKDPMAGIQDLMKKMYEEGDDEMKRTIAKAWTEAQSKNLKMP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUB5</accession>
    <name>Q5CUB5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large Sec7 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_3480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626899.1">
        <property type="nucleotide sequence ID" value="XM_626899.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUB5"/>
    <dbReference type="GeneID" id="3374115"/>
    <dbReference type="KEGG" id="cpv:cgd3_3480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3480"/>
    <dbReference type="InParanoid" id="Q5CUB5"/>
    <dbReference type="OMA" id="KKFYYKI"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF375">
        <property type="entry name" value="LD29171P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="2">
        <location>
            <begin position="517"/>
            <end position="708"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1908"/>
            <end position="1935"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1261"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1912"/>
            <end position="1935"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2578" mass="304881" checksum="2413B4BE895B6CD0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUB9</accession>
    <name>Q5CUB9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Heat shock protein HSP70, mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_3440</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626895.1">
        <property type="nucleotide sequence ID" value="XM_626895.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUB9"/>
    <dbReference type="SMR" id="Q5CUB9"/>
    <dbReference type="FunCoup" id="Q5CUB9">
        <property type="interactions" value="263"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUB9"/>
    <dbReference type="GeneID" id="3374119"/>
    <dbReference type="KEGG" id="cpv:cgd3_3440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3440"/>
    <dbReference type="InParanoid" id="Q5CUB9"/>
    <dbReference type="OMA" id="MGTDWKI"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11733">
        <property type="entry name" value="ASKHA_NBD_HSP70_HSPA9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000014">
        <property type="entry name" value="Chaperone protein DnaK HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000003">
        <property type="entry name" value="Heat shock protein 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000004">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000003">
        <property type="entry name" value="Molecular chaperone DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00332">
        <property type="entry name" value="DnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012725">
        <property type="entry name" value="Chaperone_DnaK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02350">
        <property type="entry name" value="prok_dnaK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0346">Stress response</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="654"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="296"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="606"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="659"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="683" mass="74642" checksum="2C18E60EE260727D" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUE9</accession>
    <name>Q5CUE9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Transcription factor TFIIH with a vWA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_3110</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626865.1">
        <property type="nucleotide sequence ID" value="XM_626865.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUE9"/>
    <dbReference type="FunCoup" id="Q5CUE9">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUE9"/>
    <dbReference type="GeneID" id="3373883"/>
    <dbReference type="KEGG" id="cpv:cgd3_3110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3110"/>
    <dbReference type="InParanoid" id="Q5CUE9"/>
    <dbReference type="OMA" id="INWVEVP"/>
    <dbReference type="OrthoDB" id="284275at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000439">
        <property type="term" value="C:transcription factor TFIIH core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005675">
        <property type="term" value="C:transcription factor TFIIH holo complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.410">
        <property type="entry name" value="von Willebrand factor, type A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046349">
        <property type="entry name" value="C1-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007198">
        <property type="entry name" value="Ssl1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004595">
        <property type="entry name" value="TFIIH_C1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012170">
        <property type="entry name" value="TFIIH_SSL1/p44"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036465">
        <property type="entry name" value="vWFA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00622">
        <property type="entry name" value="ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12695:SF2">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04056">
        <property type="entry name" value="Ssl1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01047">
        <property type="entry name" value="C1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57889">
        <property type="entry name" value="Cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53300">
        <property type="entry name" value="vWA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="365"/>
            <end position="417"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="423" mass="47985" checksum="266C470F8C00FDB7" modified="2005-04-12" version="1">MDFAEKLADTSNNSLDEQEVVYSWEQGLIKNWERLVETESGLVVIDDETRFDSNNADESYNIELLKRGPNTNIRRGLLRNIVIILDMTSNMLELDYKPDRLQCMVKCNEIFIKQLLEDNPLTQISVISIYDGIGEVIISYNSNFLEIMTSILNYLKKGCKGSMSIQNGLEKAKYLLVSIPPYGTKEIIFFLGSMRSVDNSFLFNEWVEGFSSNNIIINAILFIPELYIIKTITKMTGGVCLCAMNNDHLLKLTLENFIKPPPNNIASTPLNINLVTMGFPEYVSNQTHPFGCSCHRSLTHRGYSCPKCKSIVCYLPTKCPVCLIYLISPNHLAKSFAYLFQHPDITPIKNGEYSKIESSSIKTKCELCESQFSNNVYLNSGSRSNIINKYLCTNCSTQFCNECCKFIFNTLHQCPICCSLRIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUG5</accession>
    <name>Q5CUG5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Cysteine protease</fullName>
            <ecNumber evidence="11">3.4.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd3_2920</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>[protein]-C-terminal L-amino acid-glycyl-phosphatidylethanolamide + H2O = [protein]-C-terminal L-amino acid-glycine + a 1,2-diacyl-sn-glycero-3-phosphoethanolamine</text>
            <dbReference type="Rhea" id="RHEA:67548"/>
            <dbReference type="Rhea" id="RHEA-COMP:17323"/>
            <dbReference type="Rhea" id="RHEA-COMP:17324"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:64612"/>
            <dbReference type="ChEBI" id="CHEBI:172940"/>
            <dbReference type="ChEBI" id="CHEBI:172941"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67549"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the peptidase C54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.-" evidence="11"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626849.1">
        <property type="nucleotide sequence ID" value="XM_626849.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUG5"/>
    <dbReference type="STRING" id="353152.Q5CUG5"/>
    <dbReference type="GeneID" id="3374102"/>
    <dbReference type="KEGG" id="cpv:cgd3_2920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2920"/>
    <dbReference type="InParanoid" id="Q5CUG5"/>
    <dbReference type="OMA" id="CMIRSTQ"/>
    <dbReference type="OrthoDB" id="2960936at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019786">
        <property type="term" value="F:protein-phosphatidylethanolamide deconjugating activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035973">
        <property type="term" value="P:aggrephagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000423">
        <property type="term" value="P:mitophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016485">
        <property type="term" value="P:protein processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005078">
        <property type="entry name" value="Peptidase_C54"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046792">
        <property type="entry name" value="Peptidase_C54_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624:SF49">
        <property type="entry name" value="CYSTEINE PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22624">
        <property type="entry name" value="CYSTEINE PROTEASE ATG4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03416">
        <property type="entry name" value="Peptidase_C54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 11" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 11" id="KW-0645">Protease</keyword>
    <keyword evidence="8 11" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Peptidase C54 catalytic" evidence="12">
        <location>
            <begin position="42"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010958"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029362"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK89038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="348" mass="40060" checksum="6764ABC1724BF6B2" modified="2005-04-12" version="1">MNFGRTIYFSISSFFREMTQKFLSAEEEIFMLKNKFAPEEKKYFLKEFHDIILFTYRNEFKNIIITRNTVQLTKNYSKNINSDVGWGCMYRVTQMSIAHGICQFMKRFLGNLNIEKILNNFQDNESAKFSIHNMVNIGLSEFGIDPTSWIGPTTSSMIANKLINDNRSIISNIQIASITYVEGTIYRDQAVKHFSEVGSDSCTFVWLCMKLGTSKFNINSYKKTVISMSNVSQFICIMGGNNYSSGALLIVAFSNSFLYCLDPHIKVLPSFSDKNFIRDDFIQKVPTRIYWGELNSSLSMVYICRNLEDFDDLCSNLTRINSDLFEVINNCDFEVKSINELDSGFLVV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUP9</accession>
    <name>Q5CUP9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TCTP domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_1940</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the TCTP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626765.1">
        <property type="nucleotide sequence ID" value="XM_626765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUP9"/>
    <dbReference type="FunCoup" id="Q5CUP9">
        <property type="interactions" value="289"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUP9"/>
    <dbReference type="GeneID" id="3374146"/>
    <dbReference type="KEGG" id="cpv:cgd3_1940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1940"/>
    <dbReference type="InParanoid" id="Q5CUP9"/>
    <dbReference type="OMA" id="CAMITEG"/>
    <dbReference type="OrthoDB" id="10248936at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.150.10">
        <property type="entry name" value="Metal Binding Protein, Guanine Nucleotide Exchange Factor, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011057">
        <property type="entry name" value="Mss4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011323">
        <property type="entry name" value="Mss4/transl-control_tumour"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034737">
        <property type="entry name" value="TCTP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018105">
        <property type="entry name" value="Translational_control_tumour_p"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991">
        <property type="entry name" value="TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11991:SF0">
        <property type="entry name" value="TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00838">
        <property type="entry name" value="TCTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01653">
        <property type="entry name" value="TCTPROTEIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51316">
        <property type="entry name" value="Mss4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51797">
        <property type="entry name" value="TCTP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TCTP" evidence="3">
        <location>
            <begin position="1"/>
            <end position="172"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="172" mass="19982" checksum="37A1FC2EE354FDCE" modified="2005-04-12" version="1">MKVYKCIFTGDEVMSDSYKQTSPFGKAEFDDIAFEVQSKRVQKSAEDFGIAHNTEEGEAEVVDADVETVNDIIDAFKLESTPFTKKEYMTYIKAYLARIKEAMEKSNPDRVETFMKNAQTFVKYLLERFDDLEFYLGPSLDCEGIIIYGYYEDGDLAPRFIYFKDALNEERY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUQ4</accession>
    <name>Q5CUQ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane bound phosphatase with 3 transmembrane domains and a dual specificity phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_1890</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89108.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626760.1">
        <property type="nucleotide sequence ID" value="XM_626760.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUQ4"/>
    <dbReference type="STRING" id="353152.Q5CUQ4"/>
    <dbReference type="GeneID" id="3374151"/>
    <dbReference type="KEGG" id="cpv:cgd3_1890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1890"/>
    <dbReference type="InParanoid" id="Q5CUQ4"/>
    <dbReference type="OMA" id="ERANYSS"/>
    <dbReference type="OrthoDB" id="16692at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016314">
        <property type="term" value="F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14510">
        <property type="entry name" value="PTP_VSP_TPTE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.190.10">
        <property type="entry name" value="Protein tyrosine phosphatase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051281">
        <property type="entry name" value="Dual-spec_lipid-protein_phosph"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029021">
        <property type="entry name" value="Prot-tyrosine_phosphatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045102">
        <property type="entry name" value="PTP_VSP_TPTE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029023">
        <property type="entry name" value="Tensin_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016130">
        <property type="entry name" value="Tyr_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000387">
        <property type="entry name" value="Tyr_Pase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12305">
        <property type="entry name" value="PHOSPHATASE WITH HOMOLOGY TO TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22785">
        <property type="entry name" value="Tc-R-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52799">
        <property type="entry name" value="(Phosphotyrosine protein) phosphatases II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51181">
        <property type="entry name" value="PPASE_TENSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00383">
        <property type="entry name" value="TYR_PHOSPHATASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50056">
        <property type="entry name" value="TYR_PHOSPHATASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="40"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="76"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatase tensin-type" evidence="4">
        <location>
            <begin position="173"/>
            <end position="349"/>
        </location>
    </feature>
    <feature type="domain" description="Tyrosine specific protein phosphatases" evidence="3">
        <location>
            <begin position="279"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89108.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="734" mass="85376" checksum="801E06845D1B57E1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUV6</accession>
    <name>Q5CUV6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1330</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626708.1">
        <property type="nucleotide sequence ID" value="XM_626708.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUV6"/>
    <dbReference type="GeneID" id="3373985"/>
    <dbReference type="KEGG" id="cpv:cgd3_1330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1330"/>
    <dbReference type="InParanoid" id="Q5CUV6"/>
    <dbReference type="OMA" id="TECCHKA"/>
    <dbReference type="OrthoDB" id="344280at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254256" evidence="2">
        <location>
            <begin position="24"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="32"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="362"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="36"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="69"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="132"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="364"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="429"/>
            <end position="455"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="514" mass="55434" checksum="21E7F6201DEB1F35" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUZ7</accession>
    <name>Q5CUZ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89181.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626667.1">
        <property type="nucleotide sequence ID" value="XM_626667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUZ7"/>
    <dbReference type="GeneID" id="3374127"/>
    <dbReference type="KEGG" id="cpv:cgd3_850"/>
    <dbReference type="InParanoid" id="Q5CUZ7"/>
    <dbReference type="OrthoDB" id="343690at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="15"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89181.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="122" mass="13787" checksum="588CD07E8C7DC707" modified="2005-04-12" version="1">MFDFINKYVGEVANASASENTEKTLSETGSTPPPEESSDEESDVISHTMDWGFLDYVEHLLMLSRSDEGEDLEITKTKVIQDSWSSIDNRALSLHKALLIKVSLKVFIHLLLFTIKYSSIFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV07</accession>
    <name>Q5CV07_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626657.1">
        <property type="nucleotide sequence ID" value="XM_626657.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV07"/>
    <dbReference type="GeneID" id="3374136"/>
    <dbReference type="KEGG" id="cpv:cgd3_740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_740"/>
    <dbReference type="InParanoid" id="Q5CV07"/>
    <dbReference type="OMA" id="WHIENIV"/>
    <dbReference type="OrthoDB" id="341588at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="78"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="224"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="256"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="285"/>
            <end position="305"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="351" mass="40709" checksum="D52EEF2547C726B6" modified="2005-04-12" version="1">MIGNNDVLGILGTKPLNNLIKDNLFLENEQFNESLSDYWKSFLWEFQFSRLYFKLARGDCRIIFSNSWLPYVNHSKVLLFRLFCLVFFCTIILYDIFTEIKIWRIENLARYYTTNWCSIATIGYFLVLSIVSIQAQNLVSSSIDDNIYGKNIAEIEDIIGKASYLNWTCWYAWMIQSFLLPTGLIVNIGYWMVSHPNTSVTLILAIAKHAIASILVFWDCYSTYQPFFLLHGLYLYAYIIGILLAIGAINLFPNSFLSLLPISINGLYTFFNFNDENHIKIAPSLLIFIFTLFYPLLLIFLWFLFREKNLLVDPLPNNNLISSSESKCEIMKAETSEKVALISNDEQLEKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV31</accession>
    <name>Q5CV31_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626633.1">
        <property type="nucleotide sequence ID" value="XM_626633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV31"/>
    <dbReference type="GeneID" id="3373802"/>
    <dbReference type="KEGG" id="cpv:cgd3_480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_480"/>
    <dbReference type="InParanoid" id="Q5CV31"/>
    <dbReference type="OMA" id="HYINRII"/>
    <dbReference type="OrthoDB" id="340991at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254541" evidence="1">
        <location>
            <begin position="28"/>
            <end position="366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="366" mass="42565" checksum="D0FD274C4BACF5E2" modified="2005-04-12" version="1">MRNIRFFPLLGIFVLGLIIICFGVSECYQEEKSLEGSQVFQEDPQFKLEQSGSYKEDPERMRNLDEFIKYLVNDVLFPLEGIVKGYCLFRSVSDEAKEDLGLYNKESIAVATILLSGKWKNPINFILRCRESLRVVSNGMKVSSFEHSSESWSSITSARRKMKASRIKICFKARICSRMMKKEEGTDNLRRFLINRTQYGLIYPDQGSEMAVWNTVREFKDILSAGILKGSIKNHIRVIIMFNYMNKILSQIGKQPVTLFVCIALINSMVRERSLSEWLSFSRSKTSSRNRLNELGIDPVTNLRYDTRLNIKENIINFQIRTCNHVIWTSEVLLSERQVQVIGVNSNQIYTLRKRITWMCNKMFTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV36</accession>
    <name>Q5CV36_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">VPS13p like protein involved in vacuolar sorting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626628.1">
        <property type="nucleotide sequence ID" value="XM_626628.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV36"/>
    <dbReference type="GeneID" id="3373808"/>
    <dbReference type="KEGG" id="cpv:cgd3_430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_430"/>
    <dbReference type="InParanoid" id="Q5CV36"/>
    <dbReference type="OMA" id="EYEINIF"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="622"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1942"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3822"/>
            <end position="3864"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="4330"/>
            <end position="4368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="629"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1944"/>
            <end position="1961"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="3822"/>
            <end position="3854"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="3855"/>
            <end position="3864"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="4330"/>
            <end position="4353"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="4354"/>
            <end position="4366"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="4420" mass="505019" checksum="B048825660130B58" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV41</accession>
    <name>Q5CV41_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89224.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626623.1">
        <property type="nucleotide sequence ID" value="XM_626623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV41"/>
    <dbReference type="STRING" id="353152.Q5CV41"/>
    <dbReference type="GeneID" id="3373998"/>
    <dbReference type="KEGG" id="cpv:cgd3_380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_380"/>
    <dbReference type="InParanoid" id="Q5CV41"/>
    <dbReference type="OMA" id="CQEIRIN"/>
    <dbReference type="OrthoDB" id="342766at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="530"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="614"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="802"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1060"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="710"/>
            <end position="720"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="725"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="802"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="813"/>
            <end position="827"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="829"/>
            <end position="852"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="933"/>
            <end position="943"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1024"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89224.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1060" mass="115426" checksum="73D29E0F394CF462" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV50</accession>
    <name>Q5CV50_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">DNA-3-methyladenine glycosidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_5410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkylbase DNA glycosidase AlkA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89739.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627419.1">
        <property type="nucleotide sequence ID" value="XM_627419.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV50"/>
    <dbReference type="STRING" id="353152.Q5CV50"/>
    <dbReference type="GeneID" id="3374666"/>
    <dbReference type="KEGG" id="cpv:cgd8_5410"/>
    <dbReference type="InParanoid" id="Q5CV50"/>
    <dbReference type="OMA" id="WYIWRSL"/>
    <dbReference type="OrthoDB" id="415889at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032993">
        <property type="term" value="C:protein-DNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032131">
        <property type="term" value="F:alkylated DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008725">
        <property type="term" value="F:DNA-3-methyladenine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043916">
        <property type="term" value="F:DNA-7-methylguanine glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006307">
        <property type="term" value="P:DNA alkylation repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000004">
        <property type="entry name" value="DNA-3-methyladenine glycosylase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051912">
        <property type="entry name" value="Alkylbase_DNA_Glycosylase/TA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43003:SF5">
        <property type="entry name" value="DNA-3-METHYLADENINE GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="4">
        <location>
            <begin position="55"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89739.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="217" mass="25564" checksum="17F1CD69A9F063F2" modified="2005-04-12" version="1" fragment="single">NYHSMKFNYTERELEVLKLRDEKMKKIIEEIGYIDREYIDDLFQGLFYIIIGQQVSQKAQVSIWNKAKTTLKSIDPETISNYSLEEIRKVGVSLKKATFIKGIAEKIINKEIDLNLLHEKDDEEVCEELTKLNGIGVWSAEMAMIFCMNRKNVFSFSDIAIKRALKMIYGHKEITKEIFEHYRELFSPYCSIVSLYLWEISNGDYKDKLSKKNVKLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV62</accession>
    <name>Q5CV62_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Large protein with possible signal peptide and acidic plus glycine repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_5290</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627407.1">
        <property type="nucleotide sequence ID" value="XM_627407.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV62"/>
    <dbReference type="GeneID" id="3374227"/>
    <dbReference type="KEGG" id="cpv:cgd8_5290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5290"/>
    <dbReference type="InParanoid" id="Q5CV62"/>
    <dbReference type="OMA" id="SRKGSYM"/>
    <dbReference type="OrthoDB" id="344366at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254988" evidence="3">
        <location>
            <begin position="23"/>
            <end position="2256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="551"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2063"/>
            <end position="2095"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="2172"/>
            <end position="2206"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="157"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="577"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="630"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="660"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="704"/>
            <end position="717"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="718"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="750"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="787"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="816"/>
            <end position="838"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="839"/>
            <end position="851"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="852"/>
            <end position="863"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="886"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="911"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="951"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="986"/>
            <end position="997"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="1050"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1125"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="2067"/>
            <end position="2086"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="2192"/>
            <end position="2201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2256" mass="248368" checksum="6DAFB43A890CD774" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVA6</accession>
    <name>Q5CVA6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Proteolipid subunit of the vacuolar ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_4790</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the V-ATPase proteolipid subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89611.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627363.1">
        <property type="nucleotide sequence ID" value="XM_627363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVA6"/>
    <dbReference type="FunCoup" id="Q5CVA6">
        <property type="interactions" value="192"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVA6"/>
    <dbReference type="GeneID" id="3374351"/>
    <dbReference type="KEGG" id="cpv:cgd8_4790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4790"/>
    <dbReference type="InParanoid" id="Q5CVA6"/>
    <dbReference type="OMA" id="TSPYMWG"/>
    <dbReference type="OrthoDB" id="10264021at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18177">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18178">
        <property type="entry name" value="ATP-synt_Vo_c_ATP6F_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.120.610:FF:000002">
        <property type="entry name" value="V-type proton ATPase proteolipid subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.610">
        <property type="entry name" value="lithium bound rotor ring of v- atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002379">
        <property type="entry name" value="ATPase_proteolipid_c-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000245">
        <property type="entry name" value="ATPase_proteolipid_csu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035921">
        <property type="entry name" value="F/V-ATP_Csub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10263">
        <property type="entry name" value="V-TYPE PROTON ATPASE PROTEOLIPID SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00137">
        <property type="entry name" value="ATP-synt_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00122">
        <property type="entry name" value="VACATPASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81333">
        <property type="entry name" value="F1F0 ATP synthase subunit C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="7 9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="18"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="60"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="110"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="152"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="21"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="domain" description="V-ATPase proteolipid subunit C-like" evidence="10">
        <location>
            <begin position="114"/>
            <end position="171"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU363060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89611.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="181" mass="19354" checksum="ED87F4EE1588022F" modified="2005-04-12" version="1">MAYQTYSEIFLSIPPLHFAYLGVVLCIVLSTFGAGWGIFTTGNSLVGAALRSPRIRSKNLISVIFCEATAIYGVIATFLLMSKIRSLPDIDIISGQPKDAWEVQIVKSSWILLCSGLTIGLSNLFSGISVGITGSSTALADAQRGELFSKMLVVEIFAGALGLFGMIVGFYQLSLADFPSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVB7</accession>
    <name>Q5CVB7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apicomplexan specific Pf 23612804 and Py 23478322</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4670</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627352.1">
        <property type="nucleotide sequence ID" value="XM_627352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVB7"/>
    <dbReference type="STRING" id="353152.Q5CVB7"/>
    <dbReference type="GeneID" id="3374451"/>
    <dbReference type="KEGG" id="cpv:cgd8_4670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4670"/>
    <dbReference type="InParanoid" id="Q5CVB7"/>
    <dbReference type="OMA" id="QFGEKQQ"/>
    <dbReference type="OrthoDB" id="311468at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="23"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="194" mass="22900" checksum="5D4BFD073EF6DFA0" modified="2005-04-12" version="1">MKEVSDDIYSRVRKIKFKRLGLDPSKKSNQSEKVDYNNNKKDKDDEHQYLVSFNSKVEEKKKKGEGRIITSNTTVQGFHTKFQQELKIGDYIEIEHPNTLIKESRQVVSIVSERTLIVDSEFSCDLVSTSEYYYYTNTNDNDLDILNKSNTYSYREKDGMFKYKTVVKSVNSKLSREDILDIRAKKQRDKYCWI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVG2</accession>
    <name>Q5CVG2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CCAAT-binding factor domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_4170</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CBF/MAK21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89562.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627307.1">
        <property type="nucleotide sequence ID" value="XM_627307.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVG2"/>
    <dbReference type="GeneID" id="3374192"/>
    <dbReference type="KEGG" id="cpv:cgd8_4170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4170"/>
    <dbReference type="InParanoid" id="Q5CVG2"/>
    <dbReference type="OMA" id="EIWCNDE"/>
    <dbReference type="OrthoDB" id="28947at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005612">
        <property type="entry name" value="CCAAT-binding_factor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040155">
        <property type="entry name" value="CEBPZ/Mak21-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048">
        <property type="entry name" value="CCAAT-BINDING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12048:SF0">
        <property type="entry name" value="CCAAT_ENHANCER-BINDING PROTEIN ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03914">
        <property type="entry name" value="CBF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CCAAT-binding factor" evidence="3">
        <location>
            <begin position="512"/>
            <end position="744"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="662"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="662"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="682"/>
            <end position="691"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF03914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89562.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1024" mass="120228" checksum="25926BAE3E62EF51" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVH3</accession>
    <name>Q5CVH3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ribosomal protein S29</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_4050</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the universal ribosomal protein uS14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89726.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627296.1">
        <property type="nucleotide sequence ID" value="XM_627296.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVH3"/>
    <dbReference type="FunCoup" id="Q5CVH3">
        <property type="interactions" value="285"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVH3"/>
    <dbReference type="GeneID" id="3374625"/>
    <dbReference type="KEGG" id="cpv:cgd8_4050"/>
    <dbReference type="InParanoid" id="Q5CVH3"/>
    <dbReference type="OMA" id="HCFREIA"/>
    <dbReference type="OrthoDB" id="10252683at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.830.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.830.10">
        <property type="entry name" value="30s Ribosomal Protein S14, Chain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001209">
        <property type="entry name" value="Ribosomal_uS14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018271">
        <property type="entry name" value="Ribosomal_uS14_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039744">
        <property type="entry name" value="RIbosomal_uS14_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043140">
        <property type="entry name" value="Ribosomal_uS14_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF004424">
        <property type="entry name" value="PRK05766.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12010:SF2">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00253">
        <property type="entry name" value="Ribosomal_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00527">
        <property type="entry name" value="RIBOSOMAL_S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89726.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="64" mass="7663" checksum="A6B8E4C7DEE589A3" modified="2005-04-12" version="1" fragment="single">NKTYINLRMGYSKVYNSHPKTYGQGSRCCRVCYNHHGLIRKYSLNICRQCFRERAEAIGFHKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVS4</accession>
    <name>Q5CVS4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Yh1017wp/PTM1-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_2950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89474.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627195.1">
        <property type="nucleotide sequence ID" value="XM_627195.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVS4"/>
    <dbReference type="STRING" id="353152.Q5CVS4"/>
    <dbReference type="GeneID" id="3374327"/>
    <dbReference type="KEGG" id="cpv:cgd8_2950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2950"/>
    <dbReference type="InParanoid" id="Q5CVS4"/>
    <dbReference type="OMA" id="WIAYEVY"/>
    <dbReference type="OrthoDB" id="19932at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053937">
        <property type="entry name" value="GOST_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009637">
        <property type="entry name" value="GPR107/GPR108-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229:SF1">
        <property type="entry name" value="GH17801P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21229">
        <property type="entry name" value="LUNG SEVEN TRANSMEMBRANE RECEPTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06814">
        <property type="entry name" value="GOST_TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="228"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="420"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="domain" description="GOST seven transmembrane" evidence="7">
        <location>
            <begin position="197"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF06814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89474.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="559" mass="64674" checksum="7902B82D9842C47F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVX1</accession>
    <name>Q5CVX1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_2470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627148.1">
        <property type="nucleotide sequence ID" value="XM_627148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVX1"/>
    <dbReference type="GeneID" id="3374273"/>
    <dbReference type="KEGG" id="cpv:cgd8_2470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2470"/>
    <dbReference type="InParanoid" id="Q5CVX1"/>
    <dbReference type="OMA" id="DEVAYRP"/>
    <dbReference type="OrthoDB" id="340700at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="49"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="77"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="208"/>
            <end position="247"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="208"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="247" mass="26181" checksum="D3E2A699A8CB1949" modified="2005-04-12" version="1">MCSFGSSGLYSVPPSEKCRKYARQLKFLLIIEFMTLIILFVLVPTGGTVWVLLQVFSIILAYISVKDANAYRPPILQMYIFISALGTLFCTIYFAVSLSIAGSPLSIAACTLFAVNALVLAACTRISWQLFKELMLCSPLITGTTGAYIFGTATSNANNGPSSHSNMNNGPIEMTNDRASMSNPFTGSNIGSSGGFVPFGGEGYKLSGSKNSASNEKPVTLGSSSKSIGGNSTDNNVSNNNEIKSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVY2</accession>
    <name>Q5CVY2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cold shock RNA binding domain of the OB fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_2340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89694.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627137.1">
        <property type="nucleotide sequence ID" value="XM_627137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVY2"/>
    <dbReference type="STRING" id="353152.Q5CVY2"/>
    <dbReference type="GeneID" id="3374391"/>
    <dbReference type="KEGG" id="cpv:cgd8_2340"/>
    <dbReference type="InParanoid" id="Q5CVY2"/>
    <dbReference type="OMA" id="GKVVSWM"/>
    <dbReference type="OrthoDB" id="422005at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04458">
        <property type="entry name" value="CSP_CDS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011129">
        <property type="entry name" value="CSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002059">
        <property type="entry name" value="CSP_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46565">
        <property type="entry name" value="COLD SHOCK DOMAIN PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46565:SF20">
        <property type="entry name" value="COLD SHOCK DOMAIN-CONTAINING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00313">
        <property type="entry name" value="CSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00050">
        <property type="entry name" value="COLDSHOCK"/>
    </dbReference>
    <dbReference type="SMART" id="SM00357">
        <property type="entry name" value="CSP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51857">
        <property type="entry name" value="CSD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CSD" evidence="2">
        <location>
            <begin position="10"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="112"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89694.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="135" mass="15054" checksum="7982187B131A1EEE" modified="2005-04-12" version="1" fragment="single">EKPIKLVKMPLSGVCKWFDSTKGFGFITPDDGSEDIFVHQQNIKVEGFRSLAQDERVEYEIETDDKGRRKAVNVSGPNGAPVKGDRRRGRGRGRGRGMRGRGRGGRGRGFYQNQNQSQPQSQQQPVSTQSQPVAH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVZ1</accession>
    <name>Q5CVZ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Rat1 Kar1/Rat1 like 5'-3' exonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_2250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627128.1">
        <property type="nucleotide sequence ID" value="XM_627128.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CVZ1">
        <property type="interactions" value="463"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVZ1"/>
    <dbReference type="GeneID" id="3374485"/>
    <dbReference type="KEGG" id="cpv:cgd8_2250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2250"/>
    <dbReference type="InParanoid" id="Q5CVZ1"/>
    <dbReference type="OMA" id="TCNSAFF"/>
    <dbReference type="OrthoDB" id="372487at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004534">
        <property type="term" value="F:5'-3' RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000956">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18673">
        <property type="entry name" value="PIN_XRN1-2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.1050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12390">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027073">
        <property type="entry name" value="5_3_exoribonuclease"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041412">
        <property type="entry name" value="Xrn1_helical"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004859">
        <property type="entry name" value="Xrn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017151">
        <property type="entry name" value="Xrn2/3/4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341:SF41">
        <property type="entry name" value="5'-3' EXORIBONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12341">
        <property type="entry name" value="5'-&gt;3' EXORIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17846">
        <property type="entry name" value="XRN_M"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03159">
        <property type="entry name" value="XRN_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037239">
        <property type="entry name" value="Exonuclease_Xrn2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0269">Exonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Xrn1 N-terminal" evidence="9">
        <location>
            <begin position="1"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="10">
        <location>
            <begin position="364"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="domain" description="Xrn1 helical" evidence="10">
        <location>
            <begin position="687"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="544"/>
            <end position="581"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="614"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1228"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="8">
        <location>
            <begin position="1228"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1251"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="1262"/>
            <end position="1285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="1324"/>
            <end position="1335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006994"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022839"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF03159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF17846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1350" mass="155969" checksum="DAE710F07281A294" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVZ2</accession>
    <name>Q5CVZ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_2240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627127.1">
        <property type="nucleotide sequence ID" value="XM_627127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVZ2"/>
    <dbReference type="GeneID" id="3374484"/>
    <dbReference type="KEGG" id="cpv:cgd8_2240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2240"/>
    <dbReference type="InParanoid" id="Q5CVZ2"/>
    <dbReference type="OrthoDB" id="10505534at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="106" mass="12204" checksum="58DC7F0240C570AF" modified="2005-04-12" version="1">MLQVKTILKKFVFQKNNKNLDFKKIAIPLFGKITNNQTKCEKQFNTAITNQPITKYKNIVTVHCIRHAESTMNALRNHNIKTLNIHELLSSKDPGKLLSSFPIIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW14</accession>
    <name>Q5CW14_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">N-alpha-acetyltransferase 60</fullName>
            <ecNumber evidence="7">2.3.1.259</ecNumber>
            <ecNumber evidence="1">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_2010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-methionyl-[transmembrane protein] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-methionyl-[transmembrane protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50604"/>
            <dbReference type="Rhea" id="RHEA-COMP:12745"/>
            <dbReference type="Rhea" id="RHEA-COMP:12746"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64731"/>
            <dbReference type="ChEBI" id="CHEBI:133414"/>
            <dbReference type="EC" id="2.3.1.259"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the acetyltransferase family. NAA60 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.259" evidence="7"/>
    <dbReference type="EC" id="2.3.1.48" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627105.1">
        <property type="nucleotide sequence ID" value="XM_627105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW14"/>
    <dbReference type="STRING" id="353152.Q5CW14"/>
    <dbReference type="GeneID" id="3374494"/>
    <dbReference type="KEGG" id="cpv:cgd8_2010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2010"/>
    <dbReference type="InParanoid" id="Q5CW14"/>
    <dbReference type="OMA" id="QTWKQWF"/>
    <dbReference type="OrthoDB" id="47374at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120518">
        <property type="term" value="F:protein N-terminal-methionine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045141">
        <property type="entry name" value="NAA60-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14744:SF15">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="3" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="11">
        <location>
            <begin position="39"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00025774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00026111"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="290" mass="34045" checksum="6AB960D0A737BA91" modified="2005-04-12" version="1">MTTISSAFPPELKNPAKCSRVHDVYQGWKHENPTKNPIIDFRRVIPEDVAQLEELHKELFPIVYDKQFYEGIASGITHGWVAVWRLRESLESSYFESDELIIGFVTTSQDCRIIKDNDYKHVIKSIPEPFLLQELREKIQDESFEISPSPFGVNVYKYLVYILTMGVVEEFRFLGIAKQLLNTVIGYYQKFSPTVNALFLHVVDYNSSAINLYRRLKFEEILHWNNFYKILDGFYGSYLFSYNYDRSDSTNLFDSYIDIGSNFQADQRRKYGLFNYINKFISNSSKLPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW45</accession>
    <name>Q5CW45_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89376.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627074.1">
        <property type="nucleotide sequence ID" value="XM_627074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW45"/>
    <dbReference type="GeneID" id="3374601"/>
    <dbReference type="KEGG" id="cpv:cgd8_1680"/>
    <dbReference type="InParanoid" id="Q5CW45"/>
    <dbReference type="OMA" id="MASTCIR"/>
    <dbReference type="OrthoDB" id="343209at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="310"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="105"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="193"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="246"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="314"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89376.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="481" mass="53833" checksum="C54F49048322F2E2" modified="2005-04-12" version="1">MPPKSKGQTIQLRDLQRMAYENGEVMEGILPTQSLGLERTDSYNSNRGGSRMSSRYDNDEKIAQMLETDWRKGRDGGDLQRTNSKSGRDRFNRPDIDDAIYNTNWRDDAGRSTEKPKPELDFRRGTSKNYDNSSEPSSINFNWRDSSNSAQSGTGSSSGFGSRFGRENSAKVHVDDRPDYLKNRFKKRTDIENTTQSNGSNNVTNSSNIDNISFSQKLNISDPKPSSNTASNHSSSLNGILNLNNRPQQSNNTQTTSKVEKKPKQVKKIQPVKETKKIDDSETNLALWEVSDPIILNTFEKELFAFLTGETPKENSSPASPIEPNTYSPPSSDKIHGFISNFVEKSISPEDSQSLSIIAKLSHVFTLFSTAMRCIDDVILLSKSLSPIFNHFITKNKAGEATAKLYILIEIQRMASVIGNPKVDNVTSILESLWISLLKSKIVSRDTFNLWLSKNDLLGEDSKLGRKNALFEVSLFLFGVD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW58</accession>
    <name>Q5CW58_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Coiled coil, low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_1540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89366.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627061.1">
        <property type="nucleotide sequence ID" value="XM_627061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW58"/>
    <dbReference type="GeneID" id="3374474"/>
    <dbReference type="KEGG" id="cpv:cgd8_1540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1540"/>
    <dbReference type="InParanoid" id="Q5CW58"/>
    <dbReference type="OrthoDB" id="2161449at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039102">
        <property type="entry name" value="FAM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059029">
        <property type="entry name" value="FAM13A_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904">
        <property type="entry name" value="FAM13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15904:SF17">
        <property type="entry name" value="RHO-GAP DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26116">
        <property type="entry name" value="FAM13A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM13A-like" evidence="2">
        <location>
            <begin position="130"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="FAM13A-like" evidence="2">
        <location>
            <begin position="191"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="262"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF26116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89366.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="264" mass="30890" checksum="A25B474C9807F734" modified="2005-04-12" version="1">MNNEASRLVNLYIKNIPSFYQFQVVKAQYEENNINNNLSSLESINYKLIETQKKVNERYQLLLNNSQINQFTNDSDISGEERLLSILETLGLELTENGIINIPNNPLVNTETGNNSDNVNSLTFITTTNNNNFLNTLKSNIKSELKKFDSDFQMLYGKLPSKSDKEPLKPLYLLYRHLKDSTYRTKNHPTQDLISEIESLKKKKTQLRGLLETFQDQFLKKNHRKVLYHKDLLPIEKEYLEYKSIKNKIKQLEDIYSNQKLNST</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW92</accession>
    <name>Q5CW92_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">HECT-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="2">2.3.2.26</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_1200</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.26"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.26" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627027.1">
        <property type="nucleotide sequence ID" value="XM_627027.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW92"/>
    <dbReference type="GeneID" id="3374261"/>
    <dbReference type="KEGG" id="cpv:cgd8_1200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:Cgd8_1200"/>
    <dbReference type="InParanoid" id="Q5CW92"/>
    <dbReference type="OMA" id="FALHSRI"/>
    <dbReference type="OrthoDB" id="8068875at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00078">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2410.10:FF:000003">
        <property type="entry name" value="probable E3 ubiquitin-protein ligase HERC4 isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044611">
        <property type="entry name" value="E3A/B/C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45700:SF2">
        <property type="entry name" value="UBIQUITIN-PROTEIN LIGASE E3C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0436">Ligase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="HECT" evidence="6">
        <location>
            <begin position="1197"/>
            <end position="1561"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="5">
        <location>
            <position position="1529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1561" mass="184249" checksum="A2C74BDF56E67513" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW93</accession>
    <name>Q5CW93_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627026.1">
        <property type="nucleotide sequence ID" value="XM_627026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW93"/>
    <dbReference type="GeneID" id="3374570"/>
    <dbReference type="KEGG" id="cpv:cgd8_1190"/>
    <dbReference type="InParanoid" id="Q5CW93"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="102" mass="11937" checksum="4C7C07CAD08A762F" modified="2005-04-12" version="1">MEMHVKAGNEQLEETLTKSEETLHAENSIESTISEETLNSSLNNTTIDKRNIINNKKKLVLNELKEKWKNKKERYLYELDDIIDDLSDYSLNESLSIETNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWJ1</accession>
    <name>Q5CWJ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Nucleolar protein GU2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_4860</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90174.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627813.1">
        <property type="nucleotide sequence ID" value="XM_627813.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWJ1"/>
    <dbReference type="FunCoup" id="Q5CWJ1">
        <property type="interactions" value="243"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWJ1"/>
    <dbReference type="GeneID" id="3375919"/>
    <dbReference type="KEGG" id="cpv:cgd6_4860"/>
    <dbReference type="InParanoid" id="Q5CWJ1"/>
    <dbReference type="OMA" id="CESFKLC"/>
    <dbReference type="OrthoDB" id="4255at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12937">
        <property type="entry name" value="GUCT_RH7_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.2280">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012562">
        <property type="entry name" value="GUCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08152">
        <property type="entry name" value="GUCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="7">
        <location>
            <begin position="95"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="8">
        <location>
            <begin position="325"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="514"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="699"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="6">
        <location>
            <begin position="706"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90174.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="738" mass="81836" checksum="1F59DD670F429F10" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWS1</accession>
    <name>Q5CWS1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Glutaredoxin-like protein 2 thioredoxin folds</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_3970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90002.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627733.1">
        <property type="nucleotide sequence ID" value="XM_627733.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWS1"/>
    <dbReference type="FunCoup" id="Q5CWS1">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWS1"/>
    <dbReference type="GeneID" id="3375747"/>
    <dbReference type="KEGG" id="cpv:cgd6_3970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3970"/>
    <dbReference type="InParanoid" id="Q5CWS1"/>
    <dbReference type="OMA" id="DYGHYNI"/>
    <dbReference type="OrthoDB" id="415696at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03028">
        <property type="entry name" value="GRX_PICOT_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002109">
        <property type="entry name" value="Glutaredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033658">
        <property type="entry name" value="GRX_PICOT-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004480">
        <property type="entry name" value="Monothiol_GRX-rel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293">
        <property type="entry name" value="GLUTAREDOXIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10293:SF73">
        <property type="entry name" value="GLUTAREDOXIN-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00462">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51354">
        <property type="entry name" value="GLUTAREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0408">Iron</keyword>
    <keyword evidence="3" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutaredoxin" evidence="4">
        <location>
            <begin position="131"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90002.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="219" mass="24675" checksum="141D42FB8E57B8D9" modified="2007-04-03" version="1">MSTTLNSFVGITDFVLGNCLSAILILSGKEEIDGSLLELENVLQESFSNVKFGKISPSGVNEISAIKQFDVKELPSILLFTCQSLKPYKVISGYNPSELHTNLEELIKIQNLSIPSQNEKFKILTNFKSLMVFMKGIKEEPYCRFAKGLVSLLDSIKVKNYGHYNIFENEETRQGLKEYHNWPTFPQICINGEFIGGLDILNEMHSNGELVNEIPKDAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWT1</accession>
    <name>Q5CWT1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">HOI-POLLOI protein U4/U6.U5 snRNP component Snu13p pelota RNA binding domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_3850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Common component of the spliceosome and rRNA processing machinery.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
            <location evidence="1 9">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the eukaryotic ribosomal protein eL8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89993.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627723.1">
        <property type="nucleotide sequence ID" value="XM_627723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWT1"/>
    <dbReference type="FunCoup" id="Q5CWT1">
        <property type="interactions" value="507"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWT1"/>
    <dbReference type="GeneID" id="3375738"/>
    <dbReference type="KEGG" id="cpv:cgd6_3850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3850"/>
    <dbReference type="InParanoid" id="Q5CWT1"/>
    <dbReference type="OMA" id="IKNQIYA"/>
    <dbReference type="OrthoDB" id="1924699at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd21104">
        <property type="entry name" value="SNU13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000002">
        <property type="entry name" value="NHP2-like protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002415">
        <property type="entry name" value="H/ACA_rnp_Nhp2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004038">
        <property type="entry name" value="Ribosomal_eL8/eL30/eS12/Gad45"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018492">
        <property type="entry name" value="Ribosomal_eL8/Nhp2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01248">
        <property type="entry name" value="Ribosomal_L7Ae"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00881">
        <property type="entry name" value="L7ARS6FAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00883">
        <property type="entry name" value="NUCLEARHMG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Ribosomal protein eL8/eL30/eS12/Gadd45" evidence="10">
        <location>
            <begin position="28"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU366039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89993.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="134" mass="14445" checksum="22392CEAD493E483" modified="2007-04-03" version="1">MSQNEASEDTGFNPKAFPLASPDLNNKIINLVQQACNYKQLRKGANEATKALNRGIAEIVLLAADAEPLEILLHLPLVCEDKNTPYVFVRSKVALGRACGVSRPVIAAAITSKDGSSLSSQITELKDQIEQILV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWU8</accession>
    <name>Q5CWU8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Signal peptide, large secreted protein with N terminal ankyrin repeats + 8+ transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_3650</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627706.1">
        <property type="nucleotide sequence ID" value="XM_627706.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWU8"/>
    <dbReference type="GeneID" id="3375728"/>
    <dbReference type="KEGG" id="cpv:cgd6_3650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3650"/>
    <dbReference type="InParanoid" id="Q5CWU8"/>
    <dbReference type="OMA" id="QSANTHQ"/>
    <dbReference type="OrthoDB" id="20872at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004540">
        <property type="term" value="F:RNA nuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24141:SF1">
        <property type="entry name" value="2-5A-DEPENDENT RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254492" evidence="7">
        <location>
            <begin position="21"/>
            <end position="2330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1117"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1303"/>
            <end position="1325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1332"/>
            <end position="1352"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1907"/>
            <end position="1929"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="1980"/>
            <end position="2004"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="2234"/>
            <end position="2254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="2309"/>
            <end position="2328"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1159"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1589"/>
            <end position="1610"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="753"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1159"/>
            <end position="1177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1592"/>
            <end position="1604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2330" mass="265982" checksum="7252823559582F30" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWV9</accession>
    <name>Q5CWV9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627695.1">
        <property type="nucleotide sequence ID" value="XM_627695.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3375715"/>
    <dbReference type="KEGG" id="cpv:cgd6_3520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3520"/>
    <dbReference type="InParanoid" id="Q5CWV9"/>
    <dbReference type="OMA" id="SHEMIRM"/>
    <dbReference type="OrthoDB" id="435593at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148:SF14">
        <property type="entry name" value="MYND-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16148">
        <property type="entry name" value="NF-KAPPA-B-REPRESSING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="348"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1030"/>
            <end position="1079"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1399" mass="157884" checksum="805440C4AF13EA89" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWZ3</accession>
    <name>Q5CWZ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89943.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627661.1">
        <property type="nucleotide sequence ID" value="XM_627661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWZ3"/>
    <dbReference type="GeneID" id="3375688"/>
    <dbReference type="KEGG" id="cpv:cgd6_3150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3150"/>
    <dbReference type="InParanoid" id="Q5CWZ3"/>
    <dbReference type="OMA" id="ITIGQRA"/>
    <dbReference type="OrthoDB" id="339991at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007268">
        <property type="entry name" value="Rad9/Ddc1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04139">
        <property type="entry name" value="Rad9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="347"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="448"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="356"/>
            <end position="369"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89943.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="485" mass="55177" checksum="6A1E5EAF34D9CC2F" modified="2007-04-03" version="1">MISVEGDNSIIKQLNNCLSCLLRGFKCQDVLIRITNEYLMLYSFPFGGFSSCFQFNFDGRLFDKFETGDIVEFERLYKVDSLIKCFNNTQWFKATRFIFEISGNDDDTLRVTLHGKIGVIRKHCIYPVIGHQDRILLHETIFWKRRHGLRISSGLLKDIFGYMEIKESKMTLSISSQESLISIKVQPIGISGYDVPITGSSIGTGNTSGNSVSNNSTYQDIQIKKEQIDTLSLCESILENSNFTFNSREFKIAIALAENCQLPVFITLRAPGSPLIISIGQRAIIDQMCVSDLGNDIIPFEYHWEKPLFHSKLFEIDHEFIEKTQIITGFSAVFLLSTSIDPESPPDLVTSFNSPIEDHDPDQDQDRDQDYHAPMVISQMSEPRNYTPVSSKNISDIKKDYSPTSSKAIREAPPEECSLKKEVETFDCSFSKLDQFNLDSIFQKFGIENQDSSKDPENSNNYSKIDIPTKDQGVKSFDWISSLLW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX28</accession>
    <name>Q5CX28_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RRM domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_2740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627626.1">
        <property type="nucleotide sequence ID" value="XM_627626.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX28"/>
    <dbReference type="STRING" id="353152.Q5CX28"/>
    <dbReference type="GeneID" id="3375889"/>
    <dbReference type="KEGG" id="cpv:cgd6_2740"/>
    <dbReference type="InParanoid" id="Q5CX28"/>
    <dbReference type="OMA" id="CENPERG"/>
    <dbReference type="OrthoDB" id="439808at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050441">
        <property type="entry name" value="RBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48034">
        <property type="entry name" value="TRANSFORMER-2 SEX-DETERMINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="27"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="103"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="105"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="225"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="270"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="299"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="324"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="344" mass="40661" checksum="03A0BE6C47981562" modified="2005-04-12" version="1" fragment="single">VLCEKVLLLGLKNNMANPVRGNRDPRRSLLIRSLRFDTPTSLVRREFERFGAIRDVYLPLDYRSRRPRGFGFVEYVEEEDARAALEKMDGATLDGVTINVTFAQEGRKSPESMRHREYESFHGNGGRHLSGHRYGPHNHYKSDPYRRYPSPRDYREGSRSYGGNRHPPYRSRSRSPPPSRGYERYKEQYNYRRDEDFRREDYPRSHNIRGRSYSNGNEGGNYRSEIYERNYPQRDSARSYSRGRSRSRSGSIGRSRSRSRSRDRIRSRSRSMSEFGSRNVSCSVSRNRSTSLNQSSCENPERGRNNHRKIETPQNESNFFQKEFMNEHNEKNYDRSDSDRQMSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX99</accession>
    <name>Q5CX99_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Origin recognition complex subunit 3 winged helix C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627555.1">
        <property type="nucleotide sequence ID" value="XM_627555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX99"/>
    <dbReference type="GeneID" id="3376068"/>
    <dbReference type="KEGG" id="cpv:cgd6_1940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1940"/>
    <dbReference type="InParanoid" id="Q5CX99"/>
    <dbReference type="OMA" id="DATHENR"/>
    <dbReference type="OrthoDB" id="342182at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040855">
        <property type="entry name" value="ORC_WH_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18137">
        <property type="entry name" value="WHD_ORC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 3 winged helix C-terminal" evidence="1">
        <location>
            <begin position="688"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="945" mass="110075" checksum="ED95C6F724781D48" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXC4</accession>
    <name>Q5CXC4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">p23 HSP20-like chaperones fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_1630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the p23/wos2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90130.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627530.1">
        <property type="nucleotide sequence ID" value="XM_627530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXC4"/>
    <dbReference type="STRING" id="353152.Q5CXC4"/>
    <dbReference type="GeneID" id="3375875"/>
    <dbReference type="KEGG" id="cpv:cgd6_1630"/>
    <dbReference type="InParanoid" id="Q5CXC4"/>
    <dbReference type="OMA" id="EEGPYWP"/>
    <dbReference type="OrthoDB" id="1564555at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051131">
        <property type="term" value="P:chaperone-mediated protein complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06465">
        <property type="entry name" value="p23_hB-ind1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045250">
        <property type="entry name" value="p23-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932:SF1">
        <property type="entry name" value="CO-CHAPERONE PROTEIN DAF-41"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22932">
        <property type="entry name" value="TELOMERASE-BINDING PROTEIN P23 HSP90 CO-CHAPERONE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253941" evidence="3">
        <location>
            <begin position="25"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="domain" description="CS" evidence="4">
        <location>
            <begin position="32"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="167"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="181"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="197"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00025733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90130.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="213" mass="24773" checksum="A10CE82631BA61CF" modified="2005-04-12" version="1" fragment="single">PPSHLFVKITLTVKLLLIIRRISTVKPSFYNMLFPTVLWAQTKKALFVTVDLPDLKDYKVELEEQYLKFHANVENNEYEFRLDFLKPINKEESRYQVTRSLHFMITKKEEERWSSIVKDSSKTKNWLKCDWNRWIDTDEEENPSSKFDMFGGMDGMMGGMGGMGGFDLSQLGDMSGMGDMNFDEDDVPDDEDDEEPKGEPDCSNKCCDSEHKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXF3</accession>
    <name>Q5CXF3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89811.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627501.1">
        <property type="nucleotide sequence ID" value="XM_627501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXF3"/>
    <dbReference type="GeneID" id="3376004"/>
    <dbReference type="KEGG" id="cpv:cgd6_1300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1300"/>
    <dbReference type="InParanoid" id="Q5CXF3"/>
    <dbReference type="OMA" id="SWIECAR"/>
    <dbReference type="OrthoDB" id="347314at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039942">
        <property type="entry name" value="SBSPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920">
        <property type="entry name" value="RPE-SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920:SF5">
        <property type="entry name" value="SMB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254601" evidence="1">
        <location>
            <begin position="29"/>
            <end position="354"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89811.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="354" mass="39965" checksum="84C065DB340274C2" modified="2007-04-03" version="1">MVIFPIRYIRNTLVLFIIFFIHNINCKAQEKPEMANCPNYGSVSHGFLCLGLNKLKSFKTESWISCANECTKHSASFKYRKCKYWSWRATDFSCSLKSKSSRCSARDDSYVSGTIPTSMAGYCSTTCVVGEWSGWSRCTRSRPCGGYSERMRNVIFSPMFPGEICPNKSELRSCKLDKLRCPANCPDYGIVALGWGCSAYEIPGGGSKLIQNIDIKKCRDECINNKSCVYWSYGIWDQTIGERSTFPKIEMVSIEDGTPVCINVYNHIGCMFKLEGWVSGNSETIISEKACSIDCATSMWSNWSNCIFNPNDGQSYKKRYRSIITKNNDSGLECPDLQETSLCETTSNNERFNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXG8</accession>
    <name>Q5CXG8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627486.1">
        <property type="nucleotide sequence ID" value="XM_627486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXG8"/>
    <dbReference type="STRING" id="353152.Q5CXG8"/>
    <dbReference type="GeneID" id="3376030"/>
    <dbReference type="KEGG" id="cpv:cgd6_1140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1140"/>
    <dbReference type="InParanoid" id="Q5CXG8"/>
    <dbReference type="OrthoDB" id="341656at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="123"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="190"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="740" mass="81594" checksum="9BC411AA71746BDB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXH9</accession>
    <name>Q5CXH9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_1030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89789.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627475.1">
        <property type="nucleotide sequence ID" value="XM_627475.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXH9"/>
    <dbReference type="STRING" id="353152.Q5CXH9"/>
    <dbReference type="GeneID" id="3376099"/>
    <dbReference type="KEGG" id="cpv:cgd6_1030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1030"/>
    <dbReference type="InParanoid" id="Q5CXH9"/>
    <dbReference type="OMA" id="VDSSCHY"/>
    <dbReference type="OrthoDB" id="344184at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="84"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="108"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="150"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="161"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="193"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="215"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="230"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="257"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="320"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="323"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="398"/>
            <end position="416"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89789.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="565" mass="62050" checksum="C0980C7914762EF1" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXK2</accession>
    <name>Q5CXK2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89767.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627452.1">
        <property type="nucleotide sequence ID" value="XM_627452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXK2"/>
    <dbReference type="STRING" id="353152.Q5CXK2"/>
    <dbReference type="GeneID" id="3376057"/>
    <dbReference type="KEGG" id="cpv:cgd6_770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_770"/>
    <dbReference type="InParanoid" id="Q5CXK2"/>
    <dbReference type="OrthoDB" id="340843at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89767.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="258" mass="28229" checksum="7EEB48D8B42A42D3" modified="2007-04-03" version="1">MSYSNNANQITCQCGKQDRLLPVLPQSSNSRMMRMIQQQGCGCMTPSSLNNNQNYYFDNQSNISGCLFCQRLQHCCICDFSRRTGTGMMNQGNMFCSCCTCPMQQQFPSCQCGTNYFNTQHSNPVTPQQAQITEITNSNNGTMNGNVVGNGLDNTIPNNSTPGNVLVSTNLNSIQNQGQQITTQSELLNLKNTSINPEMINIALSGQTPESLSISIDSKGVITLGVNNHPAPVSNIPTTTNSNEESRNRIRNALGDRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXQ3</accession>
    <name>Q5CXQ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_5340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628677.1">
        <property type="nucleotide sequence ID" value="XM_628675.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXQ3"/>
    <dbReference type="GeneID" id="3372143"/>
    <dbReference type="KEGG" id="cpv:cgd7_5340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5340"/>
    <dbReference type="InParanoid" id="Q5CXQ3"/>
    <dbReference type="OMA" id="ICHNINN"/>
    <dbReference type="OrthoDB" id="339104at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="548" mass="62698" checksum="C903498D2210EC19" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXQ5</accession>
    <name>Q5CXQ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cwf5-like with 2 ZnR domains (CCCH and RRM domains missing)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_5320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90484.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628675.1">
        <property type="nucleotide sequence ID" value="XM_628673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXQ5"/>
    <dbReference type="STRING" id="353152.Q5CXQ5"/>
    <dbReference type="GeneID" id="3372141"/>
    <dbReference type="KEGG" id="cpv:cgd7_5320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5320"/>
    <dbReference type="InParanoid" id="Q5CXQ5"/>
    <dbReference type="OrthoDB" id="10259600at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071006">
        <property type="term" value="C:U2-type catalytic step 1 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071007">
        <property type="term" value="C:U2-type catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036002">
        <property type="term" value="F:pre-mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017070">
        <property type="term" value="F:U6 snRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039171">
        <property type="entry name" value="Cwc2/Slt11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048995">
        <property type="entry name" value="STL11/RBM22-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14089:SF6">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR RBM22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21369">
        <property type="entry name" value="STL11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="STL11/RBM22-like N-terminal" evidence="2">
        <location>
            <begin position="13"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF21369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90484.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="186" mass="21498" checksum="B86CFEAE6B1B9D74" modified="2005-04-12" version="1">MSHGLSYEDCNFPIVCDRCLGESKFLRMTKSNQERSCKICNRPCTMFRWKLHNSKKYNQTTICYSCGKIKNVCQSCVSDLNFGLSLYARDDYIKSKKEQGDETALQIMNIPDSVDNRDHFMENKLNGNDETFIKRIDENQKKRKEILKKILAKDDKIEAKEVTNYSKNTTECGSSSKTTIKSISKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXY9</accession>
    <name>Q5CXY9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coronin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_4400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the WD repeat coronin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628591.1">
        <property type="nucleotide sequence ID" value="XM_628589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXY9"/>
    <dbReference type="STRING" id="353152.Q5CXY9"/>
    <dbReference type="GeneID" id="3372171"/>
    <dbReference type="KEGG" id="cpv:cgd7_4400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4400"/>
    <dbReference type="InParanoid" id="Q5CXY9"/>
    <dbReference type="OMA" id="EREMAIW"/>
    <dbReference type="OrthoDB" id="1850764at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015505">
        <property type="entry name" value="Coronin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015048">
        <property type="entry name" value="DUF1899"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10856:SF0">
        <property type="entry name" value="CORONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08953">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16300">
        <property type="entry name" value="WD40_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01166">
        <property type="entry name" value="DUF1899"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01167">
        <property type="entry name" value="DUF1900"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3 4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="DUF1899" evidence="6">
        <location>
            <begin position="3"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="75"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="125"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="415"/>
            <end position="459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU280818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM01166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="463" mass="52103" checksum="7D3F8014C9CE3F01" modified="2005-04-12" version="1">MSRIVHDSKFRNLYGECMQDRFSGLHIVTSRHTVDGCGIAASTEFIAFPAECSGGGSVGVIDNSSFGYKPNVVYFKGHKAAVSDVEFSPFYSCLLVSASQDKTIKLWEIPEHAAQKSLKDPLAVFRGHTKKVSLVKFNPSAEWILASASRDNTIKIWNCETVQDEINIGLPGLPTSIKWSYDGSLLAVSCMDKVTRIIDPRSERITYQWQAHNGSRKSRCEWMGGTMGNPNWLLTTGFSDKGERQIGVWDVRYLDKSVGVEFVDIEQPSLIPFWDEGTGLFYLAGKGDTNIKVFEYSKTDGCVRRLEEYRSVNSLKGYCLTPKQNVEVMKCEIDRILRLESGGVIQPVSFIVPRKTNEFYSDLYPDAIGNEAAMGPEEWISGHTGEPMRMSLRPDIVQTQSNMFKRMRSVVKNARVILKKDLAKAEMQLSTMQDELYSIESLKYQLKEKENEIAQLKAKTSLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY11</accession>
    <name>Q5CY11_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ynl022cp-like. SUN family methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_4130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628569.1">
        <property type="nucleotide sequence ID" value="XM_628567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY11"/>
    <dbReference type="FunCoup" id="Q5CY11">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY11"/>
    <dbReference type="GeneID" id="3371944"/>
    <dbReference type="KEGG" id="cpv:cgd7_4130"/>
    <dbReference type="InParanoid" id="Q5CY11"/>
    <dbReference type="OMA" id="MNFYQHA"/>
    <dbReference type="OrthoDB" id="435282at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807:SF4">
        <property type="entry name" value="28S RRNA (CYTOSINE-C(5))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22807">
        <property type="entry name" value="NOP2 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 7" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="6">
        <location>
            <begin position="127"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="430"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="237"/>
            <end position="243"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="261"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="298"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="378"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="508" mass="57812" checksum="99A794F668A2C679" modified="2005-04-12" version="1" fragment="single">PNPMSTLYLEAAKVLNKIEKKNVGIRSVIYSEKQNKCNIRKLSALVHGVSGKRKELELILQKSHLLEDSNINQISNYWLLLVLAYEQLFGNLKIQGGGALARLVRKNKDKLYECFSKEYPDLINQVKHSKVYEQIPRYLRVNTTIESTESVLNSILDQVKQTNQFANDDIQNYIWIDKHIKNVIACKHEVAKLLCLDRIPSSNELIKTSKVVLQDKGSCFSAICAKITPGDFVLDACSAPGSKSLHIIDMLNKRGRLVALDKDSTRIKTLIKRISEVPYLAGPFVYKKKNFVTIQIEDISDECLLGEIGCIFLDKESKLIRNNKLIMIDYLDNFKPPDLLIHVAKCDFLSLTPTAEDHLLPWYHYKNTISNLRVIVLDPSCSGSGLPQHGKVESVNIEKRLKSLSEFQTKMLIHSLSSFQSVETVCYSTCSIFTEENEQVVLNSLEKCKNSGNLQFSLEIALENWENPNRSYQDSSFGEIYKKCIFVNSETHNCRGFFLAKFVKNSSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYD1</accession>
    <name>Q5CYD1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ortholog of kin17 (RNA metabolism proteins): a family of highly conserved zinc binding C-rich proteins with KOW domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2810</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628449.1">
        <property type="nucleotide sequence ID" value="XM_628447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYD1"/>
    <dbReference type="STRING" id="353152.Q5CYD1"/>
    <dbReference type="GeneID" id="3372267"/>
    <dbReference type="KEGG" id="cpv:cgd7_2810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2810"/>
    <dbReference type="InParanoid" id="Q5CYD1"/>
    <dbReference type="OrthoDB" id="10266249at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2030">
        <property type="entry name" value="DNA/RNA-binding protein Kin17, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056767">
        <property type="entry name" value="C2H2-Znf_KIN17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019447">
        <property type="entry name" value="DNA/RNA-bd_Kin17_WH-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037321">
        <property type="entry name" value="KIN17-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038254">
        <property type="entry name" value="KIN17_WH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805:SF0">
        <property type="entry name" value="DNA_RNA-BINDING PROTEIN KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12805">
        <property type="entry name" value="KIN17 KIN, ANTIGENIC DETERMINANT OF RECA PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25095">
        <property type="entry name" value="C2H2-zf_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10357">
        <property type="entry name" value="WH_KIN17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01253">
        <property type="entry name" value="Kin17_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="265" mass="31511" checksum="0469114C3ABB0483" modified="2005-04-12" version="1">MPKAEVGTVKWLSKQIKSKGLQKLRWYCQLCEKQCRDENGFKCHRMSDAHLRQMEVFEQNSKKILNDYSKQFELAFMRLMKTRYSKSKVLANTVYNDLIHDRNHIHMNSTIWTTLTEFIHYLSNTNKCEIEYSDKGWYIQYIGHEGEKKNKDLDSKNKFRLTEDNRRERRIGMVVKSNSSSNQRASFIQRCPTVFLRNTTNLEDDDGKISIQINNNRNNISEHNSVQNLFNFQEQDFTCNGNFEFQNCCQEKYKVRSSSLSREGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYG0</accession>
    <name>Q5CYG0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">14-3-3 domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_2470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2011" name="PLoS ONE" volume="6" first="e14827" last="e14827">
            <title>Characterization of 14-3-3 proteins from Cryptosporidium parvum.</title>
            <authorList>
                <person name="Brokx S.J."/>
                <person name="Wernimont A.K."/>
                <person name="Dong A."/>
                <person name="Wasney G.A."/>
                <person name="Lin Y.H."/>
                <person name="Lew J."/>
                <person name="Vedadi M."/>
                <person name="Lee W.H."/>
                <person name="Hui R."/>
            </authorList>
            <dbReference type="PubMed" id="21853016"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0014827"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.82 ANGSTROMS) OF 7-232</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628420.1">
        <property type="nucleotide sequence ID" value="XM_628418.1"/>
    </dbReference>
    <dbReference type="PDB" id="2O8P">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.82 A"/>
        <property type="chains" value="A=7-232"/>
    </dbReference>
    <dbReference type="PDBsum" id="2O8P"/>
    <dbReference type="AlphaFoldDB" id="Q5CYG0"/>
    <dbReference type="SMR" id="Q5CYG0"/>
    <dbReference type="STRING" id="353152.Q5CYG0"/>
    <dbReference type="GeneID" id="3372217"/>
    <dbReference type="KEGG" id="cpv:cgd7_2470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2470"/>
    <dbReference type="InParanoid" id="Q5CYG0"/>
    <dbReference type="OMA" id="KEHINTW"/>
    <dbReference type="OrthoDB" id="342398at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CYG0"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd08774">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="2">
        <location>
            <begin position="18"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2O8P"/>
        </source>
    </evidence>
    <sequence length="232" mass="27617" checksum="922190D7F52334EE" modified="2005-04-12" version="1">MNLLFKEMDERLLQKYRAQVFEWGGCFDKMFEALKSLIYLSEFENSEFDDEERHLLTLCIKHKISDYRTMTSQVLQEQTKQLNNDELVKICSEYVFSLRKDIKAFLQSFEDCVDRLVEKSFFSKFFKLKVKSDISRYKLEFGLCSLEDSKKIHQDAFTLLCEHPDKIEQLPLGFIQNLAYILSEKYGEKKQVFNMLNSLGKILELQIKEQENMDRKAQITVYLQGIKDYIEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYV3</accession>
    <name>Q5CYV3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90566.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628277.1">
        <property type="nucleotide sequence ID" value="XM_628275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYV3"/>
    <dbReference type="GeneID" id="3371988"/>
    <dbReference type="KEGG" id="cpv:cgd7_890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_890"/>
    <dbReference type="InParanoid" id="Q5CYV3"/>
    <dbReference type="OMA" id="NINTHPK"/>
    <dbReference type="OrthoDB" id="344118at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="61"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="193"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="553"/>
            <end position="606"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="625"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="701"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="67"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="199"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="270"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="574"/>
            <end position="591"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="628"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="653"/>
            <end position="662"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90566.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="743" mass="83985" checksum="A3D75EC0419C8F93" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYZ1</accession>
    <name>Q5CYZ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628239.1">
        <property type="nucleotide sequence ID" value="XM_628237.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYZ1"/>
    <dbReference type="GeneID" id="3371910"/>
    <dbReference type="KEGG" id="cpv:cgd7_490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_490"/>
    <dbReference type="InParanoid" id="Q5CYZ1"/>
    <dbReference type="OMA" id="KYQESNT"/>
    <dbReference type="OrthoDB" id="342947at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="136"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="214" mass="24320" checksum="5F1AAE7B45B0C8E4" modified="2005-04-12" version="1">MSSLIEIMTIVESKGGKEDVEVELSKDLPEADFNKLREQLFMMGFELQNQNIEKDQKSGSSGNTGDNCRKFKLKKESYNELIVKEISNMSLKNQQEASIPLTPKSALKSKKDNFVDKSQKLDEELAAIRAEKARQFKDSSGHSYRNTNNTCNSNNSRTSTDSQSSFRRFMNFDWFTSMFSSRRRGTSQRDRMHLDSSYYRSKNTGCCGSSCGGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPZ0</accession>
    <name>A3FPZ0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">K Homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_2980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388431.1">
        <property type="nucleotide sequence ID" value="XM_001388394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPZ0"/>
    <dbReference type="STRING" id="353152.A3FPZ0"/>
    <dbReference type="GeneID" id="3374650"/>
    <dbReference type="KEGG" id="cpv:cgd8_2980"/>
    <dbReference type="InParanoid" id="A3FPZ0"/>
    <dbReference type="OrthoDB" id="1650at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071034">
        <property type="term" value="P:CUT catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000467">
        <property type="term" value="P:exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071035">
        <property type="term" value="P:nuclear polyadenylation-dependent rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071038">
        <property type="term" value="P:TRAMP-dependent tRNA surveillance pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22525">
        <property type="entry name" value="KH-I_Rrp4_eukar"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026699">
        <property type="entry name" value="Exosome_RNA_bind1/RRP40/RRP4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321:SF4">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT RRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21321">
        <property type="entry name" value="PNAS-3 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15985">
        <property type="entry name" value="KH_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="K Homology" evidence="2">
        <location>
            <begin position="39"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="144" mass="16441" checksum="7801024DCBF10E02" modified="2007-04-03" version="1" fragment="single">MKSILDEGDVICTEVQRVQSEGICHLHTRSAKYGKLANGMVVKVPNKLIQRQAQHIVKLKYGIQLILGLNGYVWISLPFEHSHTDTLNYSSSSVKPEIVNSNIRKSIVMLAFIIKLFGLKNMQITPERICKVFDRFTELHLSYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQB0</accession>
    <name>A3FQB0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Mitogen-activated protein kinase</fullName>
            <ecNumber evidence="7">2.7.11.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd2_4340</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.24"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="7">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="7">Activated by threonine and tyrosine phosphorylation.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.24" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388246.1">
        <property type="nucleotide sequence ID" value="XM_001388209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQB0"/>
    <dbReference type="FunCoup" id="A3FQB0">
        <property type="interactions" value="34"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQB0"/>
    <dbReference type="GeneID" id="3373661"/>
    <dbReference type="KEGG" id="cpv:cgd2_4340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4340"/>
    <dbReference type="InParanoid" id="A3FQB0"/>
    <dbReference type="OMA" id="ANWEVGT"/>
    <dbReference type="OrthoDB" id="192887at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004707">
        <property type="term" value="F:MAP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07834">
        <property type="entry name" value="STKc_MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000046">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003527">
        <property type="entry name" value="MAP_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01351">
        <property type="entry name" value="MAPK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2 7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="9">
        <location>
            <begin position="139"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="93"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="111"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="169"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU361165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="563" mass="64170" checksum="3A91A2D416083235" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQB1</accession>
    <name>A3FQB1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Cyclin-dependent kinase 2 homolog</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd1_60</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="7">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388133.1">
        <property type="nucleotide sequence ID" value="XM_001388096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQB1"/>
    <dbReference type="STRING" id="353152.A3FQB1"/>
    <dbReference type="GeneID" id="3371475"/>
    <dbReference type="KEGG" id="cpv:cgd1_60"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_60"/>
    <dbReference type="InParanoid" id="A3FQB1"/>
    <dbReference type="OMA" id="IMDYCTS"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07829">
        <property type="entry name" value="STKc_CDK_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 11 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 12" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="13">
        <location>
            <begin position="28"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="57"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAZ51310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="300" mass="34570" checksum="EEE64D799E119ABA" modified="2007-04-03" version="1">MNMIQKLIWDSINFTLGDGEKDSSIGDYEYLEIIGEGTYGVVYKCKCKQSGELFAVKTFRSATSEFSTTTLREISILREINHSNIVSVQDVILSSKGVNIVFEFFPYDLKRYLSMFPDKVPPVKFIKHIIFEILKGIFHLHMHRIIHRDLKPQNILISCDRNLPDVKIADFGLSRILSTPFKTLTREVVTLWYRAPELLLGNKNYSSSIDIWSVGCIFIELLIGRPIFSGDSEVSTLFKIFKTLGTPNPKVYSNINSLPNYSPDWPKWDIDENWVDNQICMYSPTKQYLLETDAKNLIKM</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQC7</accession>
    <name>A3FQC7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd1_890</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:17990"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="9">
            <dbReference type="Rhea" id="RHEA:46609"/>
        </physiologicalReaction>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388149.1">
        <property type="nucleotide sequence ID" value="XM_001388112.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQC7"/>
    <dbReference type="GeneID" id="3371493"/>
    <dbReference type="KEGG" id="cpv:cgd1_890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_890"/>
    <dbReference type="InParanoid" id="A3FQC7"/>
    <dbReference type="OMA" id="VTIDEHI"/>
    <dbReference type="OrthoDB" id="1405469at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004694">
        <property type="term" value="F:eukaryotic translation initiation factor 2alpha kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13996">
        <property type="entry name" value="STKc_EIF2AK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050339">
        <property type="entry name" value="CC_SR_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042:SF160">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11042">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2-ALPHA KINASE EIF2-ALPHA KINASE -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0652">Protein synthesis inhibitor</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="14">
        <location>
            <begin position="667"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="418"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="611"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="764"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="855"/>
            <end position="880"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="611"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="633"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="796"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="697"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048977"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAZ51326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1332" mass="149230" checksum="C3A6B691EF78231B" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQH0</accession>
    <name>A3FQH0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51276.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388254.1">
        <property type="nucleotide sequence ID" value="XM_001388217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQH0"/>
    <dbReference type="GeneID" id="3373027"/>
    <dbReference type="KEGG" id="cpv:cgd5_560"/>
    <dbReference type="InParanoid" id="A3FQH0"/>
    <dbReference type="OMA" id="YFESRIN"/>
    <dbReference type="OrthoDB" id="390933at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="54"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="210"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51276.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="635" mass="73361" checksum="BA6817426E373FF5" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQI6</accession>
    <name>A3FQI6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Peptidase M60 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_1990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388270.1">
        <property type="nucleotide sequence ID" value="XM_001388233.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQI6"/>
    <dbReference type="MEROPS" id="M98.A03"/>
    <dbReference type="GeneID" id="3373356"/>
    <dbReference type="KEGG" id="cpv:cgd5_1990"/>
    <dbReference type="InParanoid" id="A3FQI6"/>
    <dbReference type="OMA" id="ENINMES"/>
    <dbReference type="OrthoDB" id="10260387at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.390.80">
        <property type="entry name" value="Peptidase M60, enhancin-like domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.390.30">
        <property type="entry name" value="Peptidase M60, enhancin-like domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042279">
        <property type="entry name" value="Pep_M60_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031161">
        <property type="entry name" value="Peptidase_M60_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051244">
        <property type="entry name" value="TCAF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15730">
        <property type="entry name" value="EXPERIMENTAL AUTOIMMUNE PROSTATITIS ANTIGEN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15730:SF5">
        <property type="entry name" value="SI:CH211-210B2.2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13402">
        <property type="entry name" value="Peptidase_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01276">
        <property type="entry name" value="M60-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51723">
        <property type="entry name" value="PEPTIDASE_M60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="931"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M60" evidence="2">
        <location>
            <begin position="531"/>
            <end position="900"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1025" mass="119960" checksum="1CA3F3FDA0941A2C" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQI9</accession>
    <name>A3FQI9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388273.1">
        <property type="nucleotide sequence ID" value="XM_001388236.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQI9"/>
    <dbReference type="STRING" id="353152.A3FQI9"/>
    <dbReference type="GeneID" id="3373353"/>
    <dbReference type="KEGG" id="cpv:cgd5_2160"/>
    <dbReference type="InParanoid" id="A3FQI9"/>
    <dbReference type="OMA" id="HTRESAK"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="137" mass="15396" checksum="59AB84BBE651DCB9" modified="2007-04-03" version="1" fragment="single">IDELRQFFKIVDRDKAGKISEEKIIHMLNAIGVQLTKRDKLAIKAGESNERGLYTVDDLIRIGEVVYNDRAIARDLVESLQSISNGKDTISSAELRKHLLNIGSIIKLTPEEVNCILSDIGESNINIYDFVSYCISE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQL3</accession>
    <name>A3FQL3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 7">UDP-glucose 4-epimerase</fullName>
            <ecNumber evidence="4 7">5.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd4_2600</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>UDP-alpha-D-glucose = UDP-alpha-D-galactose</text>
            <dbReference type="Rhea" id="RHEA:22168"/>
            <dbReference type="ChEBI" id="CHEBI:58885"/>
            <dbReference type="ChEBI" id="CHEBI:66914"/>
            <dbReference type="EC" id="5.1.3.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2 7">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 7">Carbohydrate metabolism; galactose metabolism.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the NAD(P)-dependent epimerase/dehydratase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.1.3.2" evidence="4 7"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51256.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388068.1">
        <property type="nucleotide sequence ID" value="XM_001388031.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQL3"/>
    <dbReference type="STRING" id="353152.A3FQL3"/>
    <dbReference type="GeneID" id="3372822"/>
    <dbReference type="KEGG" id="cpv:cgd4_2600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2600"/>
    <dbReference type="InParanoid" id="A3FQL3"/>
    <dbReference type="OMA" id="GEHLICN"/>
    <dbReference type="OrthoDB" id="9402762at2759"/>
    <dbReference type="UniPathway" id="UPA00214"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003978">
        <property type="term" value="F:UDP-glucose 4-epimerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006012">
        <property type="term" value="P:galactose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05247">
        <property type="entry name" value="UDP_G4E_1_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.25.10">
        <property type="entry name" value="UDP-galactose 4-epimerase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005886">
        <property type="entry name" value="UDP_G4E"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01179">
        <property type="entry name" value="galE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43725:SF47">
        <property type="entry name" value="UDP-GLUCOSE 4-EPIMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01713">
        <property type="entry name" value="NUCEPIMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0119">Carbohydrate metabolism</keyword>
    <keyword evidence="6 7" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5 7" id="KW-0520">NAD</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="8">
        <location>
            <begin position="9"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU366046"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51256.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="345" mass="38571" checksum="C0C25B981AEDB0BF" modified="2007-04-03" version="1">MSKSEIKILCTGGAGYIGSHTVIALIEEGYSVHILDNFSNSDPEVVNRIEKITKVKVPFFEIDIRDKERMLDLFLKERYNAVIHFAGLKAVGVSVSQPLEYYENNVVGTIRLLEVMKEANCNILVFSSSATVYLPKSTPLLETDPLGASNPYGQTKFMIELMMKDIYNASKNTKFSILRYFNPVGCHPSSLIGEDPEEPNNLLPYIQLVSIGRKEKLFVFGNDWPTRDGTGVRDYIHVTDLANGHVKALEKLLNLSNTDKTLDIYNLGCGSGISVLEMVKNFENASGKQIPYEIINRRPGDLASVIADPSKAEKELGWKAKHSIFDACKSAYDWQFNNPNGYSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPE4</accession>
    <name>Q5CPE4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_4600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000017">
        <property type="protein sequence ID" value="EAK87297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625308.1">
        <property type="nucleotide sequence ID" value="XM_625308.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPE4"/>
    <dbReference type="STRING" id="353152.Q5CPE4"/>
    <dbReference type="GeneID" id="3372310"/>
    <dbReference type="KEGG" id="cpv:cgd5_4600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4600"/>
    <dbReference type="InParanoid" id="Q5CPE4"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="43"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="61"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="159"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="182"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="203"/>
            <end position="224"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="244" mass="27847" checksum="D9663CFD11F559ED" modified="2005-04-12" version="1">MFIKNKIIIILLLLFINFLFLFENITDNFLVKKDVSLIKIRNETPNEGSSSSGNKNSEGSSRGGGGGGGGGRGKKKPVLKMMKSLPFEGSEKSSHCHHHHHKRKHCIDKKRNTAYQYIPGESSGKNMIRSSLTLPMKDLDDPSSYPSDMPSDEPSHNPDDDEEPCDDDDEEQCDEEDEEEEKYQREKEKEKNEDKHDQVDSGRKHRRKRKLRKSKSNLRSRGSGKHFSEKICGPCKNINMEDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPM0</accession>
    <name>Q5CPM0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Activator of Hsp90 ATPase homologue 1/2-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_320</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625401.1">
        <property type="nucleotide sequence ID" value="XM_625401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPM0"/>
    <dbReference type="STRING" id="353152.Q5CPM0"/>
    <dbReference type="GeneID" id="3372354"/>
    <dbReference type="KEGG" id="cpv:cgd2_320"/>
    <dbReference type="InParanoid" id="Q5CPM0"/>
    <dbReference type="OMA" id="RNGWTEN"/>
    <dbReference type="OrthoDB" id="567237at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd08892">
        <property type="entry name" value="SRPBCC_Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013538">
        <property type="entry name" value="ASHA1/2-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08327">
        <property type="entry name" value="AHSA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Activator of Hsp90 ATPase homologue 1/2-like C-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08327"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="134" mass="15474" checksum="F7E40005BF7AEB59" modified="2005-04-12" version="1" fragment="single">FRVPPRVLYNSFLDESDLTRLSLGSKCLMDPKEGGKFSLYNGSVEGTNISLDKDTRIEQNWRFSSWEEGVYSKVVIEFRPLIGEDDCTEVVLVQTGIPSLDKFGNPGCLEQCMLGWERNFWDRFEKIMGYPKFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPQ5</accession>
    <name>Q5CPQ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Possible transporter with 11 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_4450</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87405.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625459.1">
        <property type="nucleotide sequence ID" value="XM_625459.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPQ5"/>
    <dbReference type="STRING" id="353152.Q5CPQ5"/>
    <dbReference type="GeneID" id="3372439"/>
    <dbReference type="KEGG" id="cpv:cgd4_4450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4450"/>
    <dbReference type="InParanoid" id="Q5CPQ5"/>
    <dbReference type="OMA" id="WIRNISK"/>
    <dbReference type="OrthoDB" id="1684102at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="78"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="106"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="151"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="221"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="262"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="299"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="336"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="462"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="489"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="523"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="7">
        <location>
            <begin position="77"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87405.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="560" mass="61461" checksum="58477955EBA9364A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPX6</accession>
    <name>Q5CPX6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Low complexity coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625503.1">
        <property type="nucleotide sequence ID" value="XM_625503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPX6"/>
    <dbReference type="GeneID" id="3372470"/>
    <dbReference type="KEGG" id="cpv:cgd8_420"/>
    <dbReference type="InParanoid" id="Q5CPX6"/>
    <dbReference type="OMA" id="HRCSMPI"/>
    <dbReference type="OrthoDB" id="341101at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="668"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="904"/>
            <end position="944"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="26"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="106"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="162"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="730"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="782"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="671"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="904"/>
            <end position="930"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1100" mass="128456" checksum="A3B3A19E61187B34" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPZ7</accession>
    <name>Q5CPZ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625482.1">
        <property type="nucleotide sequence ID" value="XM_625482.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372501"/>
    <dbReference type="KEGG" id="cpv:cgd8_180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_180"/>
    <dbReference type="InParanoid" id="Q5CPZ7"/>
    <dbReference type="OMA" id="IMKSKEC"/>
    <dbReference type="OrthoDB" id="340782at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2484" mass="290090" checksum="2BEE8D3DF896A2B4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ22</accession>
    <name>Q5CQ22_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD40 repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_4430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625604.1">
        <property type="nucleotide sequence ID" value="XM_625604.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ22"/>
    <dbReference type="STRING" id="353152.Q5CQ22"/>
    <dbReference type="GeneID" id="3372555"/>
    <dbReference type="KEGG" id="cpv:cgd5_4430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4430"/>
    <dbReference type="InParanoid" id="Q5CQ22"/>
    <dbReference type="OMA" id="DALICHR"/>
    <dbReference type="OrthoDB" id="4096at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:2000234">
        <property type="term" value="P:positive regulation of rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011047">
        <property type="entry name" value="Quinoprotein_ADH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053826">
        <property type="entry name" value="WDR75"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44215:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 75"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50998">
        <property type="entry name" value="Quinoprotein alcohol dehydrogenase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6" id="KW-0804">Transcription</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1050" mass="119792" checksum="E04637F02953CF02" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ33</accession>
    <name>Q5CQ33_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_4310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625593.1">
        <property type="nucleotide sequence ID" value="XM_625593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ33"/>
    <dbReference type="GeneID" id="3372572"/>
    <dbReference type="KEGG" id="cpv:cgd5_4310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4310"/>
    <dbReference type="InParanoid" id="Q5CQ33"/>
    <dbReference type="OMA" id="WAENINS"/>
    <dbReference type="OrthoDB" id="342945at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="252"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="419"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="476" mass="55767" checksum="37C6D4DBECD4BE44" modified="2005-04-12" version="1">MRQFYKILNNYFNCSELNQYENLFNEKRLATSILKTVPLIFVFLDIMIMGYESFAFTNLIGLSMGSINVGPNDLEKWYFEDLVKLCFTGFVISMVHLTYLSIFDVIMDIFYCHELKRVVSNEEIGPHIQDESFMNGRNLNITSLIRESRQDIGNNSQILNDLIRDEQLLLENAINPLSISWLKYFVSSTSLLKNLQFVNLTNNEDLNELNLRNELFFSVNNSDIYYNKYVIAPRVIPIKLSEKSKWSIYRLVFIYSFLLIMYQFLDILLKFSIIYLLIQMSFWPWNFLITTTLQLIFMGMCFSFHNSPITNLIIGLFINIFGVLPLLLTSQNRIKHNVCITCSLLSLRSMEFLISILIIIIIPFNANSDDMQWLHANTGNFNVPTYLHAIKNYVWKNDVAKNIVSNINGEKSEINIDQFFWIIIAIFFIHEMLLFLVQKIITTPKSTQGEYLSENPSSERIEMANSIEYIPYFRFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ37</accession>
    <name>Q5CQ37_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_4270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87576.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625589.1">
        <property type="nucleotide sequence ID" value="XM_625589.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ37"/>
    <dbReference type="FunCoup" id="Q5CQ37">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ37"/>
    <dbReference type="GeneID" id="3372575"/>
    <dbReference type="KEGG" id="cpv:cgd5_4270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4270"/>
    <dbReference type="InParanoid" id="Q5CQ37"/>
    <dbReference type="OMA" id="DITWPIN"/>
    <dbReference type="OrthoDB" id="339187at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="498"/>
            <end position="522"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87576.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="530" mass="63652" checksum="47C8205D63351DC9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ67</accession>
    <name>Q5CQ67_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ran-binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_3950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625559.1">
        <property type="nucleotide sequence ID" value="XM_625559.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ67"/>
    <dbReference type="FunCoup" id="Q5CQ67">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ67"/>
    <dbReference type="GeneID" id="3372603"/>
    <dbReference type="KEGG" id="cpv:cgd5_3950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3950"/>
    <dbReference type="InParanoid" id="Q5CQ67"/>
    <dbReference type="OMA" id="HYIYPNK"/>
    <dbReference type="OrthoDB" id="2357150at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005643">
        <property type="term" value="C:nuclear pore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006913">
        <property type="term" value="P:nucleocytoplasmic transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13179">
        <property type="entry name" value="RanBD_RanBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000312">
        <property type="entry name" value="Ran binding protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000156">
        <property type="entry name" value="Ran_bind_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045255">
        <property type="entry name" value="RanBP1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045256">
        <property type="entry name" value="RanBP1_RanBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138:SF87">
        <property type="entry name" value="E3 SUMO-PROTEIN LIGASE RANBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23138">
        <property type="entry name" value="RAN BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00638">
        <property type="entry name" value="Ran_BP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00160">
        <property type="entry name" value="RanBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50196">
        <property type="entry name" value="RANBD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RanBD1" evidence="2">
        <location>
            <begin position="50"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="187"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="218"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="218" mass="25470" checksum="B87EB1DEAE4E976E" modified="2005-04-12" version="1">MSELEKKFELGTPNPATQEPKPSEDATAEGGNASGDERYYPEEELTEGNWNTPQVELKQVEVMTGEEDEEEFWKHRAKLYRFVNGEWKERGVGNAKLLQHKETKKIRFLLRQEKTLKIVANHYVIQKDSFCKLTPNSGSNKIWVWTVHDFSEEQKLEQFALKFGQTEQADIFKSKFEEAVEINSKLFNTAEEEDSESKKQKDDEKKEDTSDRQNEEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ71</accession>
    <name>Q5CQ71_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">PH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_3910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625555.1">
        <property type="nucleotide sequence ID" value="XM_625555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ71"/>
    <dbReference type="GeneID" id="3372598"/>
    <dbReference type="KEGG" id="cpv:cgd5_3910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3910"/>
    <dbReference type="InParanoid" id="Q5CQ71"/>
    <dbReference type="OrthoDB" id="342079at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="518" mass="61663" checksum="0F9983CA9186CA51" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQD2</accession>
    <name>Q5CQD2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87626.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625716.1">
        <property type="nucleotide sequence ID" value="XM_625716.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQD2"/>
    <dbReference type="GeneID" id="3372669"/>
    <dbReference type="KEGG" id="cpv:cgd4_1190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1190"/>
    <dbReference type="InParanoid" id="Q5CQD2"/>
    <dbReference type="OMA" id="NSKDANY"/>
    <dbReference type="OrthoDB" id="341593at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="85"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="87"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87626.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="135" mass="16030" checksum="2F3A9DF43C513AB3" modified="2005-04-12" version="1">MAKCRGFKPGGVDNPYYYNKRKIVKQEGSTIKERLQRSTRPTWEELRKMANKTSEGFCNIDDNTIRNDEYKRKLDRTREEKLSSMMNYNSNNQNKYYKNNDNNENSCNSGKYNKVCVEKKRSRSFDRSSPNNDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQD5</accession>
    <name>Q5CQD5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Conserved protein with transmembrane region at C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_1160</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625713.1">
        <property type="nucleotide sequence ID" value="XM_625713.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQD5"/>
    <dbReference type="STRING" id="353152.Q5CQD5"/>
    <dbReference type="GeneID" id="3372619"/>
    <dbReference type="KEGG" id="cpv:cgd4_1160"/>
    <dbReference type="InParanoid" id="Q5CQD5"/>
    <dbReference type="OMA" id="THWILRR"/>
    <dbReference type="OrthoDB" id="538249at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01335">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.70">
        <property type="entry name" value="Aldolase class I"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013785">
        <property type="entry name" value="Aldolase_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040072">
        <property type="entry name" value="Methyltransferase_A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544">
        <property type="entry name" value="23S RRNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30544:SF8">
        <property type="entry name" value="RADICAL SAM SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51918">
        <property type="entry name" value="RADICAL_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="5" id="KW-0408">Iron</keyword>
    <keyword evidence="6" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="579"/>
            <end position="595"/>
        </location>
    </feature>
    <feature type="domain" description="Radical SAM core" evidence="9">
        <location>
            <begin position="141"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="116"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="116"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="602" mass="68853" checksum="AD09DC82B02B410A" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQE4</accession>
    <name>Q5CQE4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_1040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625704.1">
        <property type="nucleotide sequence ID" value="XM_625704.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQE4"/>
    <dbReference type="GeneID" id="3372679"/>
    <dbReference type="KEGG" id="cpv:cgd4_1040"/>
    <dbReference type="InParanoid" id="Q5CQE4"/>
    <dbReference type="OrthoDB" id="336008at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="216" mass="24713" checksum="620C3AC26154A33B" modified="2005-04-12" version="1">MTYCNGLILNEYEQENEDTNNIQHLNENYNNHENSSYMSMSGFIPQFIQASKYFTCFYGSNNIENSSLVNRSNHNMSLTTTITGETISENEQEIITITNNNSINNTNYSCQNQSQNQIIDFELDTSCYLNQHDGQLAPFCPIIDDENAFFSKNKNSLRKAIYIHSLYDGSNLGTIFCDDINDDSEDVVLLHYDSDGMEIACGTNYGLLRRYKHIFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQJ2</accession>
    <name>Q5CQJ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Oocyst wall protein 7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625656.1">
        <property type="nucleotide sequence ID" value="XM_625656.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQJ2"/>
    <dbReference type="STRING" id="353152.Q5CQJ2"/>
    <dbReference type="GeneID" id="3372685"/>
    <dbReference type="KEGG" id="cpv:cgd4_500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_500"/>
    <dbReference type="InParanoid" id="Q5CQJ2"/>
    <dbReference type="OMA" id="HEDHCIQ"/>
    <dbReference type="OrthoDB" id="7250310at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="709"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="709"/>
            <end position="726"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="727"/>
            <end position="739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="840" mass="93941" checksum="EC302E71CD1F55EB" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQQ6</accession>
    <name>Q5CQQ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_3700</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87753.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625946.1">
        <property type="nucleotide sequence ID" value="XM_625946.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQQ6"/>
    <dbReference type="GeneID" id="3372800"/>
    <dbReference type="KEGG" id="cpv:cgd4_3700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3700"/>
    <dbReference type="InParanoid" id="Q5CQQ6"/>
    <dbReference type="OrthoDB" id="342569at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87753.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="255" mass="29508" checksum="84861CA7820EA0CB" modified="2005-04-12" version="1">MITNIKGNNAELCDFYNDPKRRERENDYINKETFPTLDLSIEGIQESISKVWDECQQGQELLEEIDRILTILYSKISAFSSSNNACFSLQSVSELDSLVKEYEIKRSLIYETLSGKINLKSELELLYLDFIKKQFQETHIPLEGVQETTNINQSFFSNNITQMSSNSCSDWSMINEIDQNAYSSGLDSFEDDDDQDNESMILDMSISGSHSTNFEYIHQTQEDRLEQNGQEILNVLEIEQERSDDGFIPSFIFHF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQR1</accession>
    <name>Q5CQR1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625941.1">
        <property type="nucleotide sequence ID" value="XM_625941.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQR1"/>
    <dbReference type="STRING" id="353152.Q5CQR1"/>
    <dbReference type="GeneID" id="3372804"/>
    <dbReference type="KEGG" id="cpv:cgd4_3650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3650"/>
    <dbReference type="InParanoid" id="Q5CQR1"/>
    <dbReference type="OrthoDB" id="344040at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254414" evidence="1">
        <location>
            <begin position="19"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="245" mass="27949" checksum="436B16CA48AA5B07" modified="2005-04-12" version="1">MKLCNLFVLIYSIALIKQNIIDLFGGQNKIISPLLYSLLQLTAGVQGTAGSREDLNSEFGGLSLIEDEIDGEAEASGRQTVSYSHAELVSLKDSTKEPFKKIEESYRRLVEHPVDKECVAAMFLILQACISELGRSDAFCKMLRRNYNIVRKQVKNYKVVTEKYASYFKSAVSTLFSLNSLIKLNPQNVELELSFVNDIEKFLEEILSFLMRTESFIEYIILLFMKFCSPQGLTYYTNRIEGRIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQZ8</accession>
    <name>Q5CQZ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">N-methyl-D-aspartate receptor-associated protein, 7 transmembrane domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_2680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the BI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87933.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625854.1">
        <property type="nucleotide sequence ID" value="XM_625854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQZ8"/>
    <dbReference type="FunCoup" id="Q5CQZ8">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQZ8"/>
    <dbReference type="GeneID" id="3372977"/>
    <dbReference type="KEGG" id="cpv:cgd4_2680"/>
    <dbReference type="InParanoid" id="Q5CQZ8"/>
    <dbReference type="OMA" id="FHVADWD"/>
    <dbReference type="OrthoDB" id="7933078at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006214">
        <property type="entry name" value="Bax_inhibitor_1-related"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291">
        <property type="entry name" value="BAX INHIBITOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23291:SF47">
        <property type="entry name" value="TRANSMEMBRANE BAX INHIBITOR MOTIF CONTAINING 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01027">
        <property type="entry name" value="Bax1-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0675">Receptor</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="47"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="134"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="167"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="191"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="229"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU004379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87933.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="256" mass="29203" checksum="5F702AFFD8FEABD9" modified="2005-04-12" version="1" fragment="single">INFKFVIMAFEHREAVIKDLEIESNPTDSIFICNLETKLRHDFVKRVYSLLSISIAITFGIVSFFSFYETASKWLIEHYWVSVVFSICSLIFIILFSCIPSIAKSHYVGVTLLLLLSLFFGMSISGIAVCVNKFSVLLACGITILIFLALTIFSIQVKFDFTGWGPYLLIGVLIVLIYSIILIFIPRNNIAYIILGALGVMIFSFYIIYDTQLIIGGKHRQHQFCIDEYVFATISLYLDIVNVFTYILMIINSIDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR35</accession>
    <name>Q5CR35_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_2280</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87866.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625817.1">
        <property type="nucleotide sequence ID" value="XM_625817.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR35"/>
    <dbReference type="GeneID" id="3372948"/>
    <dbReference type="KEGG" id="cpv:cgd4_2280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2280"/>
    <dbReference type="InParanoid" id="Q5CR35"/>
    <dbReference type="OMA" id="PLATIRC"/>
    <dbReference type="OrthoDB" id="336925at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87866.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="253" mass="29047" checksum="3531B38CB856E461" modified="2005-04-12" version="1">MMFIFRNLFDWCKLDDNCLSVVGSSMPRNPPSKESTLKSMFSNQVYLEYEDHLDNYLLKQEAKKLTDSSSVMKFIDEGTEETKKEVNKFIELSQVFANEMINGVNIELVLGDGKAHILHLSLSKDLNALYLRRSGKKLILPLNIVSLVEIPSEKLISEAPELQNVDDCELERIVAISTVSDDWYIFIMKNPEMRDRFYQQMRLLVASIKISLVGSDRYWGKAYNGPLMDSVHIESDDEAVFLFQEEGNEVTNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR83</accession>
    <name>Q5CR83_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625769.1">
        <property type="nucleotide sequence ID" value="XM_625769.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR83"/>
    <dbReference type="GeneID" id="3372908"/>
    <dbReference type="KEGG" id="cpv:cgd4_1750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1750"/>
    <dbReference type="InParanoid" id="Q5CR83"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="69"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="110" mass="12878" checksum="46226926EFE87A5E" modified="2005-04-12" version="1">MKSDNFNKVESKTSKQDPIFISKKLRGIYAFPYIVSRRIGFISLPLTILLMCVLLFSRLHSALCINHIIIIWLILFILKYLTSFIIVSISQNNIDRLKNWNFDFNKINAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRC8</accession>
    <name>Q5CRC8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_3320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626258.1">
        <property type="nucleotide sequence ID" value="XM_626258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRC8"/>
    <dbReference type="GeneID" id="3373049"/>
    <dbReference type="KEGG" id="cpv:cgd5_3320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3320"/>
    <dbReference type="InParanoid" id="Q5CRC8"/>
    <dbReference type="OrthoDB" id="366102at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="109" mass="12722" checksum="D3490F4F243C1C53" modified="2005-04-12" version="1">MIFPTSHGNLLNLSSLLVRRSFLTSNSKQFLHIFKYFKNSKFNLNKKSEIINGDKIADQARMQEKLWKTLVPEKYITFNSSSFFFLAALTLGLHQYNVQKEKSKNSKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRD3</accession>
    <name>Q5CRD3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Secreted lipopolysaccharide sugar transferase like family 8 glycosyltransferase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88025.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626253.1">
        <property type="nucleotide sequence ID" value="XM_626253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRD3"/>
    <dbReference type="GeneID" id="3373045"/>
    <dbReference type="KEGG" id="cpv:cgd5_3260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3260"/>
    <dbReference type="InParanoid" id="Q5CRD3"/>
    <dbReference type="OrthoDB" id="6238971at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002495">
        <property type="entry name" value="Glyco_trans_8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01501">
        <property type="entry name" value="Glyco_transf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88025.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="171" mass="19582" checksum="37C4D4F32B2777A7" modified="2005-04-12" version="1">MATLKQKISLVIVIFSAIICITVPFIMGISSVKIFHRKNSSIFKSMNDSLRVKYEITFSSDKQVFPLFPTLLNSIYSNLGLGEYANVHIIAMPDVTPSDYSMLSKLNDELGFSEKLTLIFYPFTYKIKYKQTLKHVSEATMCRLLLPEMIDKRIDKILYVDTDAIVNHSLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRI4</accession>
    <name>Q5CRI4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87983.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626202.1">
        <property type="nucleotide sequence ID" value="XM_626202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRI4"/>
    <dbReference type="GeneID" id="3373221"/>
    <dbReference type="KEGG" id="cpv:cgd5_2650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2650"/>
    <dbReference type="InParanoid" id="Q5CRI4"/>
    <dbReference type="OrthoDB" id="343310at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="103"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87983.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="140" mass="15833" checksum="24C0EC0A437F6650" modified="2005-04-12" version="1">MKLRLKKLLLLLSNALIPGSGPLFYGISNISIFGIISGIAILFAFAFVILIALNGEFFSYETYNNIFLALFHRYNGHKLEKALWTILFIILVSTLTLYGYLVYLSYKITLSLNKNIQIDIKQNSKDGREPKCTKSCQTNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRS2</accession>
    <name>Q5CRS2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TsaA-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_1700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the tRNA methyltransferase O family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626114.1">
        <property type="nucleotide sequence ID" value="XM_626114.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRS2"/>
    <dbReference type="GeneID" id="3373089"/>
    <dbReference type="KEGG" id="cpv:cgd5_1700"/>
    <dbReference type="InParanoid" id="Q5CRS2"/>
    <dbReference type="OMA" id="NPRTINW"/>
    <dbReference type="OrthoDB" id="4882at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.70">
        <property type="entry name" value="YaeB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023370">
        <property type="entry name" value="TrmO-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040372">
        <property type="entry name" value="YaeB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036413">
        <property type="entry name" value="YaeB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036414">
        <property type="entry name" value="YaeB_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818">
        <property type="entry name" value="TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12818:SF0">
        <property type="entry name" value="TRNA (ADENINE(37)-N6)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01980">
        <property type="entry name" value="TrmO_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118196">
        <property type="entry name" value="YaeB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51668">
        <property type="entry name" value="TSAA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <feature type="domain" description="TsaA-like" evidence="3">
        <location>
            <begin position="20"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00033753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="316" mass="36510" checksum="21139C2CAA8C4C09" modified="2005-04-12" version="1" fragment="single">WTTGVKKKKITLKANKMIEIPIIGRVNSCYNEKWGTPRQGKYGLSSLATIELNTNIVCRDKLKDLEEHSHTILIFIFNLNKIKNSQKKNFLYINNTNAYFVHQNAKVTPPKIDSGEKRGCLATRSPHRPVPIGLTICNIVNIDLFGMKIQVGGVDIIDGTPIVEIFPYSLNYSISRNVIHTPNWVKPEKNSGIINLCIYFSFASFLDILGISKLKKIETNIQFFDDGDSYRNFNKLRNFIVEILKIDPRSRYSKKKTKLTLFGIKLFNSFQLIYHHHKMCIKVIRFLHTSNLLVEGLNPRTINWYNRLKNFISLDM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS08</accession>
    <name>Q5CS08_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88156.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626028.1">
        <property type="nucleotide sequence ID" value="XM_626028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS08"/>
    <dbReference type="STRING" id="353152.Q5CS08"/>
    <dbReference type="GeneID" id="3373143"/>
    <dbReference type="KEGG" id="cpv:cgd5_740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_740"/>
    <dbReference type="InParanoid" id="Q5CS08"/>
    <dbReference type="OMA" id="KIRAMPA"/>
    <dbReference type="OrthoDB" id="427795at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022052">
        <property type="entry name" value="Histone-bd_RBBP4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050459">
        <property type="entry name" value="WD_repeat_RBAP46/RBAP48/MSI1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22850">
        <property type="entry name" value="WD40 REPEAT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12265">
        <property type="entry name" value="CAF1C_H4-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 6" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Histone-binding protein RBBP4-like N-terminal" evidence="7">
        <location>
            <begin position="23"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="177"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="255"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="6">
        <location>
            <begin position="427"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF12265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88156.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="470" mass="53472" checksum="0FAA40E554FE500C" modified="2005-04-12" version="1">MQALTSNEGPTTLNNNVDDDIQYIWRRNCPYLYDTMLSYTLEWPTLTIDWLPNSYKSADGSYSVHKIIYGTHTSDQEPNYLIIAEVHIGDLEANDDLMNVESFAEYSYNPENTNMNIVQFEVKAKLNHPEEVNKALHMPEHPFIIASRVVNGDILVFDYSKHESFPTDEFVHPQLLLKGHSKEGYAMDWGNSTSNDYLISGGSDRIINLWDFNKNTNGILNSSAKNHFIYNNKADPDSQESSEYSPPILEPIKSISWHNSDVNDLKWHPSSLSVFGSVSDDGTFALWDLRSSSENSPSLFKNTVSGINTLSFNQFVPTMVSTGNLDGIVQIWDFRNLNEELFSFNLHSKKPIICMEWSKWSPNILMTGGVDNKVVVWDLYKNHNPSENNAYLQNGLENINQNNQTYEDPNKAHSQKDSFDPNAIFIHYGHTAPITSISWNPNEHGDPLLVASASEDNTIQFWQFSDTFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS25</accession>
    <name>Q5CS25_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Symplekin C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626011.1">
        <property type="nucleotide sequence ID" value="XM_626011.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CS25">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS25"/>
    <dbReference type="GeneID" id="3373173"/>
    <dbReference type="KEGG" id="cpv:cgd5_510"/>
    <dbReference type="InParanoid" id="Q5CS25"/>
    <dbReference type="OMA" id="THEPENK"/>
    <dbReference type="OrthoDB" id="341331at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021850">
        <property type="entry name" value="Symplekin/Pta1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022075">
        <property type="entry name" value="Symplekin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245:SF20">
        <property type="entry name" value="SYMPLEKIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15245">
        <property type="entry name" value="SYMPLEKIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12295">
        <property type="entry name" value="Symplekin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Symplekin C-terminal" evidence="3">
        <location>
            <begin position="1498"/>
            <end position="1691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="461"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="596"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="461"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="484"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF12295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1720" mass="202150" checksum="3FB373FC77B6BB33" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS65</accession>
    <name>Q5CS65_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Centrin like protein with 4x EF hands</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_60</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625971.1">
        <property type="nucleotide sequence ID" value="XM_625971.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS65"/>
    <dbReference type="FunCoup" id="Q5CS65">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS65"/>
    <dbReference type="GeneID" id="3373337"/>
    <dbReference type="KEGG" id="cpv:cgd5_60"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_60"/>
    <dbReference type="InParanoid" id="Q5CS65"/>
    <dbReference type="OMA" id="EFFMIMK"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016460">
        <property type="term" value="C:myosin II complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000077">
        <property type="entry name" value="Centrin 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050230">
        <property type="entry name" value="CALM/Myosin/TropC-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048:SF48">
        <property type="entry name" value="CENTRIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23048">
        <property type="entry name" value="MYOSIN LIGHT CHAIN 1, 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0106">Calcium</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="34"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="70"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="107"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="5">
        <location>
            <begin position="143"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="178" mass="20603" checksum="B7677D94C23EE297" modified="2005-04-12" version="1">MLQRKEHVGGISVGGASSGAASRRRRLRNEISDEQKQEIKEAFELFDTEKTGRIDYHELKVAMRALGFEVKKAQVLEIMREYDKSGSGQVEYKDFVEIMTQKILERDPREEILKAFKLFDDDNTGKISLKNLRRVARELGESISDDELQAMIEEFDKDMDGEINEEEFISIMKQTSLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS97</accession>
    <name>Q5CS97_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628170.1">
        <property type="nucleotide sequence ID" value="XM_628170.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS97"/>
    <dbReference type="GeneID" id="3371571"/>
    <dbReference type="KEGG" id="cpv:cgd1_3580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3580"/>
    <dbReference type="InParanoid" id="Q5CS97"/>
    <dbReference type="OrthoDB" id="343182at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="42"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="77"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="142" mass="15778" checksum="30E918B891E67489" modified="2005-04-12" version="1">MKLNNALCGFSLYMIFIFLLGNVASIHINRELQNLSIESEGNIKVGNSAKDSEDDVNDESNSIIKGEEEKNNDQGLTMNNTESGNSTSTENTNDNNETISQNITEADSNNNNNDSLKHHVYNGTFDLKKTFFLDGIAYNSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS99</accession>
    <name>Q5CS99_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_3560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88302.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628168.1">
        <property type="nucleotide sequence ID" value="XM_628168.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS99"/>
    <dbReference type="GeneID" id="3371573"/>
    <dbReference type="KEGG" id="cpv:cgd1_3560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3560"/>
    <dbReference type="InParanoid" id="Q5CS99"/>
    <dbReference type="OrthoDB" id="10322427at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88302.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="126" mass="14599" checksum="446647F75EF8D179" modified="2005-04-12" version="1">MDILNKENVPQKYPNRLEKLFGHYKVTLLEEGLPKTKPIDGIKMGYNDLSPMIFASNHPITPVSLLLDKKPNIYYDPNNHHHNSNDSLYDDTILPQELILYLRSISEVTISPHVIPYYEQYVLTFG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSA3</accession>
    <name>Q5CSA3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_3520</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628164.1">
        <property type="nucleotide sequence ID" value="XM_628164.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSA3"/>
    <dbReference type="STRING" id="353152.Q5CSA3"/>
    <dbReference type="GeneID" id="3371575"/>
    <dbReference type="KEGG" id="cpv:cgd1_3520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3520"/>
    <dbReference type="InParanoid" id="Q5CSA3"/>
    <dbReference type="OrthoDB" id="333966at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="400"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="348"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="348"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="373"/>
            <end position="384"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="556" mass="60346" checksum="E84505E1835C961E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSD7</accession>
    <name>Q5CSD7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-loop nucleotide (UMP) kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_3140</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>UMP + ATP = UDP + ADP</text>
            <dbReference type="Rhea" id="RHEA:24400"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58223"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.14"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the adenylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628130.1">
        <property type="nucleotide sequence ID" value="XM_628130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSD7"/>
    <dbReference type="FunCoup" id="Q5CSD7">
        <property type="interactions" value="225"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSD7"/>
    <dbReference type="GeneID" id="3371340"/>
    <dbReference type="KEGG" id="cpv:cgd1_3140"/>
    <dbReference type="InParanoid" id="Q5CSD7"/>
    <dbReference type="OMA" id="GTQCDRM"/>
    <dbReference type="OrthoDB" id="442176at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019205">
        <property type="term" value="F:nucleobase-containing compound kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016776">
        <property type="term" value="F:phosphotransferase activity, phosphate group as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006207">
        <property type="term" value="P:'de novo' pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009123">
        <property type="term" value="P:nucleoside monophosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006221">
        <property type="term" value="P:pyrimidine nucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01428">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00235">
        <property type="entry name" value="Adenylate_kinase_Adk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000850">
        <property type="entry name" value="Adenylat/UMP-CMP_kin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033690">
        <property type="entry name" value="Adenylat_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006266">
        <property type="entry name" value="UMP_CMP_kinase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01359">
        <property type="entry name" value="UMP_CMP_kin_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23359">
        <property type="entry name" value="NUCLEOTIDE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00406">
        <property type="entry name" value="ADK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00094">
        <property type="entry name" value="ADENYLTKNASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00113">
        <property type="entry name" value="ADENYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 9 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 9" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="205" mass="23563" checksum="9504B2DBDD0EFD56" modified="2005-04-12" version="1" fragment="single">FFFGIRMSQNKPFVLFCLGPPGSGKGTQCAKIVDEFSFIHLSAGDCLREAMSRKDETSELIDSYIREGLIVPVEITVGLLKKKMQEYGWNDKYFLIDGFPRNQNNLDGWYKIIPDTDVNVIGCLFLNCDDNIVVERLLHRGETSGRVDDNKETIVKRLRVYHEETTPIIEYFKNSNKCFTVDTTGSIESVWEDLKKLFREKIISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSR6</accession>
    <name>Q5CSR6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_1610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628001.1">
        <property type="nucleotide sequence ID" value="XM_628001.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSR6"/>
    <dbReference type="GeneID" id="3371645"/>
    <dbReference type="KEGG" id="cpv:cgd1_1610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1610"/>
    <dbReference type="InParanoid" id="Q5CSR6"/>
    <dbReference type="OMA" id="FICTETC"/>
    <dbReference type="OrthoDB" id="339257at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="465" mass="52778" checksum="C50685973B6B1D5D" modified="2005-04-12" version="1">MIMEHDSNYGCSGENGRIYASVGYESCSGGITEGNLQVSHSNQHINIDDIRNISPQKLICENSSCFNNNDNNNLYEPVNLTNSFMDHRESGSLPTVRRNSMRGRRRYRRTLLRNYEQPLGQNSHGNQTYIEHCDDFESNNQRRVYLRNPNIGGANGGMNYSSFKFNSNFDNYSKVSKPSWDGGRLVKLLQGHGLNIENYEKENKCLLNKSWGSKQINTQNSQLGSISNNRDFSTSAVLNGQSYVQLSHIYHGVNLKVCDVVEHQKISNTKNIQSLPSYANDQKDSFGLCHKETLIHEGNPLNQINHLEKKVFLQDNLTEGDSISNESLETQKTDRFALVSSFENQHLLKSNQNIEDSSNIIGITHKNSLFNLYESSKESDFNSERKYSITSLIPGMDKQVVNIDNQLSFNMEEHESEHASNSTYCDLNHSLYNISQEELFITLGDTPTSKSNYNISTIFVPNQDS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT51</accession>
    <name>Q5CT51_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted membrane protein with 12+xtransmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_30</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88542.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627866.1">
        <property type="nucleotide sequence ID" value="XM_627866.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT51"/>
    <dbReference type="GeneID" id="3371442"/>
    <dbReference type="KEGG" id="cpv:cgd1_30"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_30"/>
    <dbReference type="InParanoid" id="Q5CT51"/>
    <dbReference type="OMA" id="IFANFQG"/>
    <dbReference type="OrthoDB" id="341745at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="154"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="390"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="431"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="495"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="537"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="596"/>
            <end position="623"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="916"/>
            <end position="935"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1201"/>
            <end position="1223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1264"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1303"/>
            <end position="1323"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1344"/>
            <end position="1367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1379"/>
            <end position="1397"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="1409"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1581"/>
            <end position="1644"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88542.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1650" mass="190244" checksum="7A07FC89C664C267" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT77</accession>
    <name>Q5CT77_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible UBC domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_4110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626592.1">
        <property type="nucleotide sequence ID" value="XM_626592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT77"/>
    <dbReference type="GeneID" id="3373485"/>
    <dbReference type="KEGG" id="cpv:cgd2_4110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4110"/>
    <dbReference type="InParanoid" id="Q5CT77"/>
    <dbReference type="OMA" id="NINICKK"/>
    <dbReference type="OrthoDB" id="344052at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd00195">
        <property type="entry name" value="UBCc_UEV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.110.10">
        <property type="entry name" value="Ubiquitin Conjugating Enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016135">
        <property type="entry name" value="UBQ-conjugating_enzyme/RWD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54495">
        <property type="entry name" value="UBC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="556"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="556"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="764" mass="87563" checksum="3C600EACAC72A088" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT78</accession>
    <name>Q5CT78_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_4100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626591.1">
        <property type="nucleotide sequence ID" value="XM_626591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT78"/>
    <dbReference type="GeneID" id="3373488"/>
    <dbReference type="KEGG" id="cpv:cgd2_4100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4100"/>
    <dbReference type="InParanoid" id="Q5CT78"/>
    <dbReference type="OrthoDB" id="339671at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="76"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="115" mass="12347" checksum="7FEE2D455C78EB82" modified="2005-04-12" version="1">MEDSLKLQILDIYAKLIIVVSPFGAIFFILMGILMLRSTLIIEGIPVGSENYSDSTLASLIAGASFLVILILALIYRSYRAKSAAKKVANAQGNQENGYNYITGNNEGVVISSSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTC3</accession>
    <name>Q5CTC3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chorein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_3590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626546.1">
        <property type="nucleotide sequence ID" value="XM_626546.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTC3"/>
    <dbReference type="GeneID" id="3373624"/>
    <dbReference type="KEGG" id="cpv:cgd2_3590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3590"/>
    <dbReference type="InParanoid" id="Q5CTC3"/>
    <dbReference type="OMA" id="GKDHKSP"/>
    <dbReference type="OrthoDB" id="341931at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6455"/>
            <end position="6475"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="6491"/>
            <end position="6516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="338"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2439"/>
            <end position="2479"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2782"/>
            <end position="2843"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2938"/>
            <end position="2984"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3429"/>
            <end position="3449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3511"/>
            <end position="3551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="3962"/>
            <end position="3999"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="5022"/>
            <end position="5074"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="5167"/>
            <end position="5192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="5525"/>
            <end position="5573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="6090"/>
            <end position="6111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="6557"/>
            <end position="6579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="263"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="338"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2442"/>
            <end position="2457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2458"/>
            <end position="2479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2817"/>
            <end position="2843"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2938"/>
            <end position="2950"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="2951"/>
            <end position="2975"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3434"/>
            <end position="3449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3511"/>
            <end position="3520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3964"/>
            <end position="3999"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="5028"/>
            <end position="5042"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="5057"/>
            <end position="5069"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="5525"/>
            <end position="5538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="5551"/>
            <end position="5569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="6095"/>
            <end position="6108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="6567"/>
            <end position="6579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="6579" mass="761020" checksum="8B1920DA00EC83E1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTE1</accession>
    <name>Q5CTE1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_3380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the FAM76 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626528.1">
        <property type="nucleotide sequence ID" value="XM_626528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTE1"/>
    <dbReference type="GeneID" id="3373761"/>
    <dbReference type="KEGG" id="cpv:cgd2_3380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3380"/>
    <dbReference type="InParanoid" id="Q5CTE1"/>
    <dbReference type="OrthoDB" id="3689at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016607">
        <property type="term" value="C:nuclear speck"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032017">
        <property type="entry name" value="FAM76"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46176:SF1">
        <property type="entry name" value="LD21662P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16046">
        <property type="entry name" value="FAM76"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="132"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="370"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="435"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="140"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="370"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="519" mass="60508" checksum="9C9F183FABE8B586" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTV9</accession>
    <name>Q5CTV9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_1370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626360.1">
        <property type="nucleotide sequence ID" value="XM_626360.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTV9"/>
    <dbReference type="STRING" id="353152.Q5CTV9"/>
    <dbReference type="GeneID" id="3373574"/>
    <dbReference type="KEGG" id="cpv:cgd2_1370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1370"/>
    <dbReference type="InParanoid" id="Q5CTV9"/>
    <dbReference type="OMA" id="KCINTEF"/>
    <dbReference type="OrthoDB" id="340226at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="494"/>
            <end position="506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="877" mass="98152" checksum="5D0CB8034B24DBFC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="135" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTY1</accession>
    <name>Q5CTY1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA replication licensing factor MCM2</fullName>
            <ecNumber evidence="3">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd2_1100</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626338.1">
        <property type="nucleotide sequence ID" value="XM_626338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTY1"/>
    <dbReference type="FunCoup" id="Q5CTY1">
        <property type="interactions" value="447"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTY1"/>
    <dbReference type="GeneID" id="3373593"/>
    <dbReference type="KEGG" id="cpv:cgd2_1100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1100"/>
    <dbReference type="InParanoid" id="Q5CTY1"/>
    <dbReference type="OMA" id="EYQIVNW"/>
    <dbReference type="OrthoDB" id="844at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902975">
        <property type="term" value="P:mitotic DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000138">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008045">
        <property type="entry name" value="MCM2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027925">
        <property type="entry name" value="MCM_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF44">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12619">
        <property type="entry name" value="MCM2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14551">
        <property type="entry name" value="MCM_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01658">
        <property type="entry name" value="MCMPROTEIN2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="15" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="13" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="10" id="KW-0347">Helicase</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0862">Zinc</keyword>
    <keyword evidence="8" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="17">
        <location>
            <begin position="502"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="719"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="14"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00018925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAK88850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="970" mass="110388" checksum="75B72AB2F1DCCCF3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTY4</accession>
    <name>Q5CTY4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_1070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626335.1">
        <property type="nucleotide sequence ID" value="XM_626335.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTY4"/>
    <dbReference type="FunCoup" id="Q5CTY4">
        <property type="interactions" value="368"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTY4"/>
    <dbReference type="GeneID" id="3373591"/>
    <dbReference type="KEGG" id="cpv:cgd2_1070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1070"/>
    <dbReference type="InParanoid" id="Q5CTY4"/>
    <dbReference type="OMA" id="CASAYEM"/>
    <dbReference type="OrthoDB" id="10263513at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.63.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004977">
        <property type="entry name" value="Ribosomal_eS25"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12850">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03297">
        <property type="entry name" value="Ribosomal_S25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="12"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="22"/>
            <end position="31"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009106"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU366057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="106" mass="11597" checksum="B9BD2C0DC738D242" modified="2005-04-12" version="1">MPPKGEKKTKEQIAAAAAAGGRAKRKKWSKGKQKDKANHSVLFDKKTADRFHSDVLKSRLLTPAVVVNQLKVNASAARAMLRDCESKGIIKPVGEQTHGQMIYTKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU02</accession>
    <name>Q5CU02_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Phosphatidylinositol N-acetylglucosaminyltransferase subunit PIG-P, involved in GPI anchor biosynthesis, multitransmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_840</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88926.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626317.1">
        <property type="nucleotide sequence ID" value="XM_626317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU02"/>
    <dbReference type="STRING" id="353152.Q5CU02"/>
    <dbReference type="GeneID" id="3373652"/>
    <dbReference type="KEGG" id="cpv:cgd2_840"/>
    <dbReference type="InParanoid" id="Q5CU02"/>
    <dbReference type="OMA" id="QINITYY"/>
    <dbReference type="OrthoDB" id="690928at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052263">
        <property type="entry name" value="GPI_Anchor_Biosynth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013717">
        <property type="entry name" value="PIG-P"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46346:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08510">
        <property type="entry name" value="PIG-P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="PIG-P" evidence="6">
        <location>
            <begin position="11"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08510"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88926.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="204" mass="23864" checksum="AA4C8FA8FE30D7B9" modified="2005-04-12" version="1" fragment="single">DSETLTQKTKYFNSINCCFNLVVYLCWMFIPDEYLNQINITYYPDRMWGITVPIYMLFLPFMTIITYNCISILNVRPTNSFDLIIDESTRYIDLSFLYKFEDLEQIKSICKSTLKIYTMVNKNPGEKITEGGRSDHEKKYELYDDPKSAVIRQAFKSEDVTLDLVHLNNEIDSIHNNKNIIPVADLPLPLVCEMIYSDKFAGKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU33</accession>
    <name>Q5CU33_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626286.1">
        <property type="nucleotide sequence ID" value="XM_626286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU33"/>
    <dbReference type="GeneID" id="3373685"/>
    <dbReference type="KEGG" id="cpv:cgd2_490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_490"/>
    <dbReference type="InParanoid" id="Q5CU33"/>
    <dbReference type="OrthoDB" id="343800at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254965" evidence="2">
        <location>
            <begin position="26"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="320"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="175"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="241"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="263"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="343"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="378" mass="43434" checksum="69E7A2AA9D2120E1" modified="2005-04-12" version="1">MVKFTLKNTTVIILILACLGNVVKSQKQEKNSTTEVRSLGHRRGGYVGDQTVFVDRPYFVEQPVYYSYPYQYQYPYSYTYSYQYPYTYSYQYPYAGVPGYPYNYSYSYTRTTSRPGGVFTRPVGYVSPLPYAPLPGPYFRYLGNESESNERKMDVMIPMENMTPGFINDLQDGILSNGNQNNDLQNSNESLMQRNQTSSSGNNPVNNLLNRESDYLQRFPTLTGFNRAGLSGNERIIVQDRDEEEDDDENEDNNRDKNIKNNPLYNETSISSDGKRYNDTASPIKTPEIVYYNNTSNLRVLAKKGLLERVEEKVNDVFDGLKKKSNNNNDEVKDLEKEDDVDENNKKNDNKKSNQNGGKMIKQVFSTIEDIVTNTLSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU66</accession>
    <name>Q5CU66_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_4040</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626948.1">
        <property type="nucleotide sequence ID" value="XM_626948.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU66"/>
    <dbReference type="SMR" id="Q5CU66"/>
    <dbReference type="GeneID" id="3373899"/>
    <dbReference type="KEGG" id="cpv:cgd3_4040"/>
    <dbReference type="InParanoid" id="Q5CU66"/>
    <dbReference type="OMA" id="NTHGTMT"/>
    <dbReference type="OrthoDB" id="344099at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254243" evidence="2">
        <location>
            <begin position="18"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="57"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="57"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="85"/>
            <end position="118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="218" mass="24170" checksum="39A822CEDAE062D6" modified="2005-04-12" version="1">MLVCIVIAFLIIYFRERERTKTRERIERQFRMAETKKLTRYLQTLRERMMFRNQNAQINRQPNSNFQNGFPVNVGPPRGQMQFNHPPPVGPPPPVGPPPPVGPPPPVGPPPPVGPPPPQMFNQMGHPVNYPPQIQQPVFTNAPPFAPPVIPPQNFAPNCSAQPINIPPPNCPPNNSNITQGTISLTVHDPSLIPEGPPPTPPPGYVTVPIVLQNENHQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU82</accession>
    <name>Q5CU82_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd3_3860</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NUF2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89242.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626932.1">
        <property type="nucleotide sequence ID" value="XM_626932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU82"/>
    <dbReference type="FunCoup" id="Q5CU82">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU82"/>
    <dbReference type="GeneID" id="3373927"/>
    <dbReference type="KEGG" id="cpv:cgd3_3860"/>
    <dbReference type="InParanoid" id="Q5CU82"/>
    <dbReference type="OMA" id="YLKMEAH"/>
    <dbReference type="OrthoDB" id="8194677at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.418.60">
        <property type="entry name" value="Ncd80 complex, Nuf2 subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005549">
        <property type="entry name" value="Kinetochore_Nuf2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038275">
        <property type="entry name" value="Nuf2_N_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03800">
        <property type="entry name" value="Nuf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8" id="KW-0137">Centromere</keyword>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 9" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinetochore protein Nuf2 N-terminal" evidence="10">
        <location>
            <begin position="20"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="164"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="9">
        <location>
            <begin position="370"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005498"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF03800"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89242.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="493" mass="58271" checksum="BA3852BD74173F02" modified="2005-04-12" version="1" fragment="single">CTLALENKVKFKMRLQSKQKYQFPDLEMGELMNELDMLGFEVGSNFWESINHEIAVELYMNCLSIALEIDTEDIRPEELIGQLPSSAAGIISENGKSQIKPIGNLRFLRYCKILWVMIGIDDFSMNDIYRPTPDRIYSFLCGFVNLMRFKEDRWMTYKNEFYEIEEILDSVDKSNEQIKQKKEDLNNIRVRYNEQSGEIANRRRDNQEYQEKMRSLHGEFLQNQQELKRLTQSEHDLKEQLKDVEFRITTGNQDIQDLKDQVVQSPERLRNTLEELNKSLENERKQIDQISIKNNELKERQNLLQKTEKRLGKAKTFLEQTISGIKDANNIKQSIKEIEHHIEKDKWTIEQTTEEERLLLQTVEQISLRIQNNQQHYESLIEEAQTLLNQEKQKFEQGQEFLDVQSSEAFSFERQAELMEKEIQNLKVSHEKAINALNIQHSQLLNVLTNYKKHLISKLNDINSKYNLKLLDETSKENSTINSIENTIVMQHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUD6</accession>
    <name>Q5CUD6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Adenylate kinase isoenzyme 6 homolog</fullName>
            <shortName evidence="7">AK6</shortName>
            <ecNumber evidence="7">2.7.4.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Dual activity adenylate kinase/ATPase</fullName>
            <shortName evidence="7">AK/ATPase</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_3270</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. Involved in the late cytoplasmic maturation steps of the 40S ribosomal particles, specifically 18S rRNA maturation. While NMP activity is not required for ribosome maturation, ATPase activity is. Associates transiently with small ribosomal subunit protein uS11. ATP hydrolysis breaks the interaction with uS11. May temporarily remove uS11 from the ribosome to enable a conformational change of the ribosomal RNA that is needed for the final maturation step of the small ribosomal subunit. Its NMP activity may have a role in nuclear energy homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>AMP + ATP = 2 ADP</text>
            <dbReference type="Rhea" id="RHEA:12973"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.3"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="7">Interacts with small ribosomal subunit protein uS11. Not a structural component of 43S pre-ribosomes, but transiently interacts with them by binding to uS11.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the adenylate kinase family. AK6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.3" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626878.1">
        <property type="nucleotide sequence ID" value="XM_626878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUD6"/>
    <dbReference type="FunCoup" id="Q5CUD6">
        <property type="interactions" value="254"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUD6"/>
    <dbReference type="GeneID" id="3373870"/>
    <dbReference type="KEGG" id="cpv:cgd3_3270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3270"/>
    <dbReference type="InParanoid" id="Q5CUD6"/>
    <dbReference type="OMA" id="QCEIFGT"/>
    <dbReference type="OrthoDB" id="10251185at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004017">
        <property type="term" value="F:AMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00039">
        <property type="entry name" value="Adenylate_kinase_AK6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020618">
        <property type="entry name" value="Adenyl_kinase_AK6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595:SF0">
        <property type="entry name" value="ADENYLATE KINASE ISOENZYME 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12595">
        <property type="entry name" value="POS9-ACTIVATING FACTOR FAP7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13238">
        <property type="entry name" value="AAA_18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 7 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 7" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 7" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3 7" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="NMPbind" evidence="7">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="LID" evidence="7">
        <location>
            <begin position="118"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="17"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="19"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="20"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="21"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="22"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="179" mass="21024" checksum="34EE6DC5DF6B4F7A" modified="2005-04-12" version="1">MLGKGRKPNILIIGTPGTGKTSLSKKLEKKLEGYKRIELSKAIKKHRLYSEWDDKMGASIFDENLVRRYLKNQLDKYNSKNVGIILDFHSVNFIKRKWFDIVFCLNSETHVLFDRLEKRGYSQDKIKENVECEIFKVIRFDATEIFDEEQIIDLQSNNICEQRSNIKFILNKISSIENS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUK9</accession>
    <name>Q5CUK9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_2420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89076.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626805.1">
        <property type="nucleotide sequence ID" value="XM_626805.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUK9"/>
    <dbReference type="GeneID" id="3373916"/>
    <dbReference type="KEGG" id="cpv:cgd3_2420"/>
    <dbReference type="InParanoid" id="Q5CUK9"/>
    <dbReference type="OrthoDB" id="10251508at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89076.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="314" mass="36072" checksum="5F5FDB764D338C65" modified="2005-04-12" version="1">MSVNKNILFPCMKKAECNIFCPNEVLRENINSYGSIEIMDKISIFHIPSPQNNQKPKKIFVTRKECCKLLDISIDEYLFINQNLCGLKPIIKCTGKIIIKMSVTSVIIACKDVWILNPENSKTLEIIERLLECTGYNISVDNNTPSTKVSFADGISKEFISPLVENYNYNSSLECTRNNFEETEHALSSSILSTFTDINTLDNSHEYKRQESIECSISSATQEKNIDIYNYRFIPTINKDYYSHSFAAVCIEIGLEVLNKELIESINCTKNEVLKSCNILIKSSKWYKYPWRFTFSDFTNKKMISKSVNVSFFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUU0</accession>
    <name>Q5CUU0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_1490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89139.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626724.1">
        <property type="nucleotide sequence ID" value="XM_626724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUU0"/>
    <dbReference type="GeneID" id="3374029"/>
    <dbReference type="KEGG" id="cpv:cgd3_1490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1490"/>
    <dbReference type="InParanoid" id="Q5CUU0"/>
    <dbReference type="OMA" id="RYISVIC"/>
    <dbReference type="OrthoDB" id="336571at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89139.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="136" mass="15328" checksum="993D0B6346A32677" modified="2005-04-12" version="1">MKITPKMFICEVPEKILEDGDCCWIHGFVVDVEIDQDGELDMITLDDGTSNIRVSIKDKLNDANCDNFHEDTIKTYRGLIEELVQKGRLISIVCQLNKGVFKVLHVSDSINGNGDSKNEWINNSIRSRGSKEDDAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV15</accession>
    <name>Q5CV15_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Acyl-CoA synthetase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89199.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626649.1">
        <property type="nucleotide sequence ID" value="XM_626649.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV15"/>
    <dbReference type="SMR" id="Q5CV15"/>
    <dbReference type="STRING" id="353152.Q5CV15"/>
    <dbReference type="GeneID" id="3374145"/>
    <dbReference type="KEGG" id="cpv:cgd3_640"/>
    <dbReference type="InParanoid" id="Q5CV15"/>
    <dbReference type="OMA" id="YLEPISF"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23562">
        <property type="entry name" value="AMP-binding_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="122"/>
            <end position="505"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89199.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="685" mass="78183" checksum="33268FC03D517229" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV48</accession>
    <name>Q5CV48_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rasputin. nuclear transport factor 2 (NTF2) domain plus RRM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_300</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626616.1">
        <property type="nucleotide sequence ID" value="XM_626616.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV48"/>
    <dbReference type="STRING" id="353152.Q5CV48"/>
    <dbReference type="GeneID" id="3374003"/>
    <dbReference type="KEGG" id="cpv:cgd3_300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_300"/>
    <dbReference type="InParanoid" id="Q5CV48"/>
    <dbReference type="OMA" id="RPRGNAY"/>
    <dbReference type="OrthoDB" id="339151at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032710">
        <property type="entry name" value="NTF2-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002075">
        <property type="entry name" value="NTF2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018222">
        <property type="entry name" value="Nuclear_transport_factor_2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039539">
        <property type="entry name" value="Ras_GTPase_bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693:SF20">
        <property type="entry name" value="AT27578P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10693">
        <property type="entry name" value="RAS GTPASE-ACTIVATING PROTEIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02136">
        <property type="entry name" value="NTF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54427">
        <property type="entry name" value="NTF2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50177">
        <property type="entry name" value="NTF2_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="NTF2" evidence="5">
        <location>
            <begin position="16"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="371"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="163"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="337"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="453"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="176"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="245"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="295"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="345"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="357"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="456"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="472"/>
            <end position="488"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50177"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="488" mass="53668" checksum="951DDE89137AA0DE" modified="2005-04-12" version="1">MTEGTNNSSTCNASKIADFFVTEFYSRLKKDPSTLYELYHDSGYLTWVGNRSEVMDSSFNPQSAIRAETKEKIRSAINLLDLSNCTTYVEVLECSKSINNSLCITAKGRMYIGEGESVGKSFVQNFLLTEIRPRWYFIRNDCLIFIDSELPLKQSVQNTAKIANNDSGVAKNSGKKSHDSGFETNKSQKEQHHSSKVQCNDEHNKEVNKHATGPKEDDDNKSQSVATVGAHANTDSNAESQKKVSSSTAANTSNNSSNNASTSAPNTTSNNAAANTSSASSPSPLDPVNYTDSLNAKNNANINRSNPHKYEVTSYAGKLMGGALKNGNKVKGYAIHVPTEDKNKTASQNGSTKKTSTQKDPKSLKEAKNKRKIFVHSLPTNISDDQIREAVLNQLKVHGGGYVIDIERARVSGRHWGIIELDSEFSCKTLLNNGLYLGGMEISIEKWKQINQPQGQNFSQNSSKFNNKNSNRQAGNNYHHNSSNNPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVA3</accession>
    <name>Q5CVA3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4820</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627366.1">
        <property type="nucleotide sequence ID" value="XM_627366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVA3"/>
    <dbReference type="GeneID" id="3374371"/>
    <dbReference type="KEGG" id="cpv:cgd8_4820"/>
    <dbReference type="InParanoid" id="Q5CVA3"/>
    <dbReference type="OMA" id="RMAIMEY"/>
    <dbReference type="OrthoDB" id="341924at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="151"/>
            <end position="174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="174" mass="20150" checksum="B702F1AC30945E45" modified="2005-04-12" version="1">MKVESYDPRIIDQLLNTAFGKFYFSITIKYHNLHNYYVHLKKKLAFSQDLIIKSNEYARIDSRTNIQECDAKIAISEYYETITASQNSNIANKMVSSEINSLPLPTFPNKGVSKIWLPTEYEMSITPNWSQDINNVNRMNDSETEKMNQDSDIDLGQDIDDDDDDDEDLDCNNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVE9</accession>
    <name>Q5CVE9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible conserved domain (Zn finger)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627320.1">
        <property type="nucleotide sequence ID" value="XM_627320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVE9"/>
    <dbReference type="GeneID" id="3374552"/>
    <dbReference type="KEGG" id="cpv:cgd8_4320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4320"/>
    <dbReference type="InParanoid" id="Q5CVE9"/>
    <dbReference type="OrthoDB" id="339823at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="208" mass="23694" checksum="54A37BABAAEEB6FD" modified="2005-04-12" version="1">MDNGVNEYGEQLMASEEAEDSQLDEEIHKKLIPFESNIEFDETQLPEETRQIINQNTRELLRNISFSNSGGLKGAIERSYLVRQQSLAHTKEEVVDAYKQRARLAAMVSRRRVTLQHVRAQFEAVAKFKRGLKHKDKSDSDETNIPIKSKTEHYDEPNEDFNASFEVSSPIQRESSISFAPVRFGSMSISDTLALQQLANMKIGSNDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVG7</accession>
    <name>Q5CVG7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Caltractin (Centrin)-like, contains 3x EFh domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_4120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627302.1">
        <property type="nucleotide sequence ID" value="XM_627302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVG7"/>
    <dbReference type="STRING" id="353152.Q5CVG7"/>
    <dbReference type="GeneID" id="3374626"/>
    <dbReference type="KEGG" id="cpv:cgd8_4120"/>
    <dbReference type="InParanoid" id="Q5CVG7"/>
    <dbReference type="OMA" id="DFYRVFQ"/>
    <dbReference type="OrthoDB" id="343296at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050145">
        <property type="entry name" value="Centrin_CML-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23050">
        <property type="entry name" value="CALCIUM BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13405">
        <property type="entry name" value="EF-hand_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="18"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="144"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="197"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="239" mass="27037" checksum="81FA347C9C993D97" modified="2005-04-12" version="1" fragment="single">HQILLLIKVMDLGELNKEQIEDARSVFQAFDTDRNGLVDKRELKAALRALGFDVKKKDIELVFTGCFGNSYLSMSSGSNNKALGNSIGPSHMNEYLPNIGGKDFEFDRGVNFEEFCQILVYLMTSQNLFGVGAFYGTSDPSHEVSPEYVKRVFSLFDINNTGKVGIRSLRTLVSQISREPLSLSMRNSIEATDTTIFSDDDLTQMIKHIDRDGDGFLDFEDFYRVFQYCHSSTQNDINF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVH0</accession>
    <name>Q5CVH0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD-repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_4080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89554.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627299.1">
        <property type="nucleotide sequence ID" value="XM_627299.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVH0"/>
    <dbReference type="STRING" id="353152.Q5CVH0"/>
    <dbReference type="GeneID" id="3374597"/>
    <dbReference type="KEGG" id="cpv:cgd8_4080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4080"/>
    <dbReference type="InParanoid" id="Q5CVH0"/>
    <dbReference type="OMA" id="NNNILCC"/>
    <dbReference type="OrthoDB" id="10264376at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051858">
        <property type="entry name" value="WD_repeat_GAD-1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017">
        <property type="entry name" value="GASTRULATION DEFECTIVE PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16017:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89554.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="575" mass="64640" checksum="562EA9591E9244E1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVH9</accession>
    <name>Q5CVH9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89548.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627290.1">
        <property type="nucleotide sequence ID" value="XM_627290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVH9"/>
    <dbReference type="GeneID" id="3374591"/>
    <dbReference type="KEGG" id="cpv:cgd8_3990"/>
    <dbReference type="InParanoid" id="Q5CVH9"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="78"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89548.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="152" mass="16772" checksum="34237EFBF71BB4FD" modified="2005-04-12" version="1">MNEILPPPKISAQDLTGGLVRSFSKAQNDNNLFSANKGVLNVKLDKVDESEDTGNNTHVKQEVLQSEVNKNSSSISQEKNKSSNEIHDLEEGNSTHRSHHSSHHSSHHNTHRSHTQSHSSTHRSHQSGSSNDHHGPKSSKSHSSSSHSKKDR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVI2</accession>
    <name>Q5CVI2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MutS like ABC ATpase involved in DNA repair</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_3950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DNA mismatch repair MutS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89722.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627287.1">
        <property type="nucleotide sequence ID" value="XM_627287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVI2"/>
    <dbReference type="FunCoup" id="Q5CVI2">
        <property type="interactions" value="407"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVI2"/>
    <dbReference type="GeneID" id="3374612"/>
    <dbReference type="KEGG" id="cpv:cgd8_3950"/>
    <dbReference type="InParanoid" id="Q5CVI2"/>
    <dbReference type="OMA" id="KLYYAIL"/>
    <dbReference type="OrthoDB" id="295033at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032301">
        <property type="term" value="C:MutSalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03285">
        <property type="entry name" value="ABC_MSH2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1420.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.110">
        <property type="entry name" value="MutS, connector domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011184">
        <property type="entry name" value="DNA_mismatch_repair_Msh2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000432">
        <property type="entry name" value="DNA_mismatch_repair_MutS_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007696">
        <property type="entry name" value="DNA_mismatch_repair_MutS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036187">
        <property type="entry name" value="DNA_mismatch_repair_MutS_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032642">
        <property type="entry name" value="Msh2_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045076">
        <property type="entry name" value="MutS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036678">
        <property type="entry name" value="MutS_con_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361:SF35">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11361">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05192">
        <property type="entry name" value="MutS_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00488">
        <property type="entry name" value="MutS_V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005813">
        <property type="entry name" value="MSH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00534">
        <property type="entry name" value="MUTSac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00533">
        <property type="entry name" value="MUTSd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48334">
        <property type="entry name" value="DNA repair protein MutS, domain III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00486">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair proteins mutS family" evidence="7">
        <location>
            <begin position="661"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="367"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00486"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89722.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="848" mass="95917" checksum="E7267ABDEDFDBCC6" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVK4</accession>
    <name>Q5CVK4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_3730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627265.1">
        <property type="nucleotide sequence ID" value="XM_627265.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVK4"/>
    <dbReference type="GeneID" id="3374278"/>
    <dbReference type="KEGG" id="cpv:cgd8_3730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3730"/>
    <dbReference type="InParanoid" id="Q5CVK4"/>
    <dbReference type="OrthoDB" id="341277at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="270" mass="31221" checksum="764452924DC740F0" modified="2005-04-12" version="1">MESIVNTINNISDKICCLNNYFLKDEEHKSNEVYQDVNDYYSFFNTKHNLINNDIFERSLFTSIGHGNEYLELSRNNKLFGSPVSLKSYVQKSKNQIKQHIFEHLEISKNDNPIKTGCHFNEPINYYKASEMERSVIIPRSKFVSHSSNPPINKDFNVQNSNKIKIPYEPNTSITRLKTNEAEKKSIKECQISKKNYLEIPTVNRLQVQSNPLLSKVNENQIQKTPSMPTIKQYKTASRCPEPIKLGNKGMNNENNKVFLTKYGGYLLGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVK8</accession>
    <name>Q5CVK8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Mitosis protein DIM1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_3690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DIM1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627261.1">
        <property type="nucleotide sequence ID" value="XM_627261.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVK8"/>
    <dbReference type="FunCoup" id="Q5CVK8">
        <property type="interactions" value="404"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVK8"/>
    <dbReference type="GeneID" id="3374310"/>
    <dbReference type="KEGG" id="cpv:cgd8_3690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3690"/>
    <dbReference type="InParanoid" id="Q5CVK8"/>
    <dbReference type="OMA" id="GMYELYD"/>
    <dbReference type="OrthoDB" id="147752at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02954">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.30.10:FF:000004">
        <property type="entry name" value="Spliceosomal protein DIB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004123">
        <property type="entry name" value="Dim1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052:SF5">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12052">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEN 4A, 4B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02966">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017199">
        <property type="entry name" value="mRNA_splic_U5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01410">
        <property type="entry name" value="DIM1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4 6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008241"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="142" mass="16711" checksum="53AEC7469B6C0450" modified="2005-04-12" version="1">MSYMLQHLHNGWSVDQAILSEEERIVCIRFGHDYDADCMLMDEVLYKVAEDVKNFCVIYLVDITEVPDFNTMYELYDPVSVMFFFRNKHIMVDLGTGNNNKINWPLNNKQEFIDIVETIYRGVQKGKGLVVSPKDYSTKYKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVM0</accession>
    <name>Q5CVM0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627249.1">
        <property type="nucleotide sequence ID" value="XM_627249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVM0"/>
    <dbReference type="GeneID" id="3374293"/>
    <dbReference type="KEGG" id="cpv:cgd8_3560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3560"/>
    <dbReference type="InParanoid" id="Q5CVM0"/>
    <dbReference type="OMA" id="ENEDIWL"/>
    <dbReference type="OrthoDB" id="337371at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254557" evidence="1">
        <location>
            <begin position="20"/>
            <end position="503"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="503" mass="57682" checksum="B617BE95A2614BD1" modified="2005-04-12" version="1">MRCRQLIFLLFMFIRNVKSFENGLLRLVIESSQHSLNGSLDDFVSSSAENYFSFENPQQSVSCDRVFYSSSQYLDQTPPSSEFITHVPRESKSPAHFLFYTEDSLFRSRINMSQTHFPRRKHFNKNLPKLPFEPYQRIMTFAIEICMIPSIWYLELIHCMHFGMAPFFSGMLMSYSLQDVVGSAIKTMGYLDESFTIENCYRSVSSVTDEQINANFQEICESMSQCLLSNQFSSDPYLRLKEEFQQRIDNAYSNIEGQEKVEQHKNYARHSLLLSLSSKTINFSLADPATEKNFLIIRAMVLSMTYLVNKFIPVEESTISERMSKITKFINSMLFSQFKYYMKMCLISFPAILGSKSKDFQEIVGLYCKEFLSFGFIDETVKKEGDSLEAFKKAILPSRVLDPAYASVIPSLINGASSQEDLSWLSFSSVGTIEYIGVETGKKKRPKTTKYFKTASKNSISKTRSTETNTKKKSGFTKITKIFTNRKTRISGLITSHLGSADQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVQ9</accession>
    <name>Q5CVQ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Apicomplexan specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_3130</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89488.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627210.1">
        <property type="nucleotide sequence ID" value="XM_627210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVQ9"/>
    <dbReference type="STRING" id="353152.Q5CVQ9"/>
    <dbReference type="GeneID" id="3374238"/>
    <dbReference type="KEGG" id="cpv:cgd8_3130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3130"/>
    <dbReference type="InParanoid" id="Q5CVQ9"/>
    <dbReference type="OMA" id="IMTICVE"/>
    <dbReference type="OrthoDB" id="386580at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="397"/>
            <end position="447"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="372"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="496"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="372"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="496"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89488.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="518" mass="59563" checksum="778FA1A1F757FC18" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVT7</accession>
    <name>Q5CVT7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane associated DNAJ with 6 transmembrane domain, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_2820</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627182.1">
        <property type="nucleotide sequence ID" value="XM_627182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVT7"/>
    <dbReference type="STRING" id="353152.Q5CVT7"/>
    <dbReference type="GeneID" id="3374343"/>
    <dbReference type="KEGG" id="cpv:cgd8_2820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2820"/>
    <dbReference type="InParanoid" id="Q5CVT7"/>
    <dbReference type="OMA" id="FMNGCRS"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071218">
        <property type="term" value="P:cellular response to misfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051100">
        <property type="entry name" value="DnaJ_subfamily_B/C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43908:SF3">
        <property type="entry name" value="AT29763P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="33"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="173"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="218"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="350"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="57"/>
            <end position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="370" mass="43284" checksum="D1581A531C0EB617" modified="2005-04-12" version="1">MIDDQLIIYTLVISPVVGWLTSTKRTWNKKNQVNGVILALIVLVIACVLQNVRVSQNHYQTLGISSSASKSEITAAYRKLALKFHPDKNSDLSAREIYSKIRNANEILSNDLRRSWYRRFGTVENNLDLYKASEDEEFIDYPLHLTIVPFVTAVIPICLSLLMWNDQENIRRIILCFIVWTLSCGILLRFDRNENDFLTFIPIFRNFLPFEKIRVLEGLYITIMNSLQLILPFFATSFYKNELAEFYQSLLRKKLRLLIYIEDFYNEIKPKSQRTTEESGISTYNYSIVTPNFQSDALKTEVIKHMEQTSLEFNQLLIEEPFLNESWDNSFNNVYNLLEDNLDLEEKSGLSIGTIIFILFWVYKIYSAFT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVZ4</accession>
    <name>Q5CVZ4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Generative cell specific-1/HAP2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_2220</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Single-pass type I membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the HAP2/GCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627125.1">
        <property type="nucleotide sequence ID" value="XM_627125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVZ4"/>
    <dbReference type="STRING" id="353152.Q5CVZ4"/>
    <dbReference type="GeneID" id="3374482"/>
    <dbReference type="KEGG" id="cpv:cgd8_2220"/>
    <dbReference type="InParanoid" id="Q5CVZ4"/>
    <dbReference type="OrthoDB" id="339716at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007338">
        <property type="term" value="P:single fertilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040326">
        <property type="entry name" value="HAP2/GCS1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018928">
        <property type="entry name" value="HAP2/GCS1_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31764:SF0">
        <property type="entry name" value="GENERATIVE CELL SPECIFIC-1_HAP2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31764">
        <property type="entry name" value="PROTEIN HAPLESS 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10699">
        <property type="entry name" value="HAP2-GCS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="10" id="KW-0278">Fertilization</keyword>
    <keyword evidence="7" id="KW-0446">Lipid-binding</keyword>
    <keyword evidence="8" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="Generative cell specific-1/HAP2" evidence="11">
        <location>
            <begin position="16"/>
            <end position="341"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004251"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF10699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="349" mass="38971" checksum="E0D14BCF69E06937" modified="2005-04-12" version="1">MWWNVYLSKSCPVWIPPWWTAFRIGGWNWQYSLEVELSWFSPTESSINKLSSTELENMENECKKENKDSTIDCSRLRHKESGIQTSVHTLNSSSPSFYDPNFGASVQVISSGPPFGSANAKDLNGYYMLQPTFSPKGMPASISIPPLRSGCGKASKNQTEEEINDCLKPTLIIPPENADFTGVSCDKIGTSVHTWSSVNGRFCYHPPGTCQRAQIAHFYKKVIEDHSLGKISQYSVRAQNSGSPQLILDSLGEIGHEEMDQNDMGNITNIQSRRFFLGYNFDSIFDTEIMFSVEASSVSWVATSSPGIITFIEPPPLEACTAMSSFGCPLKVYIKNSGKFEYIYIYISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW30</accession>
    <name>Q5CW30_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">E2F like domain containing transcription factor with the wHTH fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_1850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the E2F/DP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627089.1">
        <property type="nucleotide sequence ID" value="XM_627089.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW30"/>
    <dbReference type="STRING" id="353152.Q5CW30"/>
    <dbReference type="GeneID" id="3374506"/>
    <dbReference type="KEGG" id="cpv:cgd8_1850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1850"/>
    <dbReference type="InParanoid" id="Q5CW30"/>
    <dbReference type="OMA" id="PPCESTV"/>
    <dbReference type="OrthoDB" id="552115at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005667">
        <property type="term" value="C:transcription regulator complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000977">
        <property type="term" value="F:RNA polymerase II transcription regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051726">
        <property type="term" value="P:regulation of cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003316">
        <property type="entry name" value="E2F_WHTH_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015648">
        <property type="entry name" value="Transcrpt_fac_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12548:SF9">
        <property type="entry name" value="TRANSCRIPTION FACTOR DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02319">
        <property type="entry name" value="WHD_E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01372">
        <property type="entry name" value="E2F_TDP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="E2F/DP family winged-helix DNA-binding" evidence="3">
        <location>
            <begin position="97"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="39"/>
            <end position="49"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="293" mass="31301" checksum="DD057949B7A9E686" modified="2005-04-12" version="1">MNNANLGAGGFVPSGYSQHPVSVGGGMEQHHPGQFKMPQGTSAGGTNEQLVSADHSSLPHLSLLPQHHLAGTGAGAGGAGNGAGGVAEYGGTPSQMRNRCKLGVFSHRVCEKVSAIKVASYHEMTEHLINMELGDGPGRSKNPEAKNIRRRVYDVLNVLLAIGVVRRSVGVGKNLIWAGLDPDRPLIDQLVERSRMDHTGRLSSGPDELRSEEQARAEVETAKIAYLTAFEAQVNALQETVRQRISTCNDKDVINVADYIGLNQLLQPVQHPHLNPPPASSNANNPISDELKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW70</accession>
    <name>Q5CW70_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Secreted alpha glucosidase like family 31 glycosyltransferase, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_1420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycan metabolism.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyl hydrolase 31 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627049.1">
        <property type="nucleotide sequence ID" value="XM_627049.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW70"/>
    <dbReference type="STRING" id="353152.Q5CW70"/>
    <dbReference type="GeneID" id="3374580"/>
    <dbReference type="KEGG" id="cpv:cgd8_1420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1420"/>
    <dbReference type="InParanoid" id="Q5CW70"/>
    <dbReference type="OMA" id="EKPINAG"/>
    <dbReference type="OrthoDB" id="440381at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090599">
        <property type="term" value="F:alpha-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006491">
        <property type="term" value="P:N-glycan processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1760">
        <property type="entry name" value="glycosyl hydrolase (family 31)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048395">
        <property type="entry name" value="Glyco_hydro_31_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025887">
        <property type="entry name" value="Glyco_hydro_31_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000322">
        <property type="entry name" value="Glyco_hydro_31_TIM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762">
        <property type="entry name" value="ALPHA-GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22762:SF54">
        <property type="entry name" value="BCDNA.GH04962"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13802">
        <property type="entry name" value="Gal_mutarotas_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01055">
        <property type="entry name" value="Glyco_hydro_31_2nd"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21365">
        <property type="entry name" value="Glyco_hydro_31_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0732">Signal</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254484" evidence="7">
        <location>
            <begin position="25"/>
            <end position="1235"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 N-terminal" evidence="9">
        <location>
            <begin position="197"/>
            <end position="411"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="8">
        <location>
            <begin position="462"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoside hydrolase family 31 TIM barrel" evidence="8">
        <location>
            <begin position="633"/>
            <end position="850"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl hydrolase family 31 C-terminal" evidence="10">
        <location>
            <begin position="858"/>
            <end position="959"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF13802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF21365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1235" mass="147689" checksum="18D22EBB8379AB23" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW74</accession>
    <name>Q5CW74_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627045.1">
        <property type="nucleotide sequence ID" value="XM_627045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW74"/>
    <dbReference type="STRING" id="353152.Q5CW74"/>
    <dbReference type="GeneID" id="3374515"/>
    <dbReference type="KEGG" id="cpv:cgd8_1380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1380"/>
    <dbReference type="InParanoid" id="Q5CW74"/>
    <dbReference type="OMA" id="RINIRKC"/>
    <dbReference type="OrthoDB" id="342657at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="239"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="844" mass="97642" checksum="4FCA1C57B8DE3F0D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW83</accession>
    <name>Q5CW83_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Integral membrane protein with 8 transmembrane domains, likely plant origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_1290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627036.1">
        <property type="nucleotide sequence ID" value="XM_627036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW83"/>
    <dbReference type="GeneID" id="3374399"/>
    <dbReference type="KEGG" id="cpv:cgd8_1290"/>
    <dbReference type="InParanoid" id="Q5CW83"/>
    <dbReference type="OMA" id="YAYCAMY"/>
    <dbReference type="OrthoDB" id="73273at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31652">
        <property type="entry name" value="LIMR FAMILY PROTEIN DDB_G0283707-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31652:SF0">
        <property type="entry name" value="LIMR FAMILY PROTEIN DDB_G0283707-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="26"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="69"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="110"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="163"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="186"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="301"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="340"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="389"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="491" mass="56761" checksum="76A5FEC72B3C0996" modified="2005-04-12" version="1" fragment="single">VNLLKVFQLFPTLTHQTFLGFFTQALVTRIVVILGLQLIWINFMLVPVNIINEYPIIGSQEFRTVNMRALFMVVMYLNILFTSLVIPFSIFYYETQFDTKIGLNRSYTPYLASFLSTLFCWIFIGGNYAIFKEIHLGSISKETCIRLTLLGYINEANCASDPLIFNGTFSIATAGLLLFIGYIFNVLFIGVASVLIPINYLISIIRRPKLIDIHLYQEKKKEIYVISKALSNKGENLKRKFDQSSKGLESEFYTSKYLKSWQETRALKQKIYKYKSEVFALSSYFENLEERFRTKGQNITFIIIKLVQMFFTLLLTISIYATLIIHIVVKNPPNYSGNQLINMIFIIFSMILPIYIGSCICYTWNLLAKKICYCLPIHVLVKSQTPMNSMIFIIGIVLIPISNIIYITNLSNSWLFKSDLYYIFLLASNIKLNYKLIPNQVLIYSLFGISICSIIIHLFSFLWDTSISIQEEIPKMLNKYLNDQESGNSKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWI3</accession>
    <name>Q5CWI3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Hsp60 GroEL-like chaperone (ATpase), predicted mitochondrial</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_4970</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the chaperonin (HSP60) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627821.1">
        <property type="nucleotide sequence ID" value="XM_627821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWI3"/>
    <dbReference type="SMR" id="Q5CWI3"/>
    <dbReference type="FunCoup" id="Q5CWI3">
        <property type="interactions" value="229"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWI3"/>
    <dbReference type="GeneID" id="3375819"/>
    <dbReference type="KEGG" id="cpv:cgd6_4970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4970"/>
    <dbReference type="InParanoid" id="Q5CWI3"/>
    <dbReference type="OMA" id="TDTDKME"/>
    <dbReference type="OrthoDB" id="1733909at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03344">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000001">
        <property type="entry name" value="60 kDa chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001844">
        <property type="entry name" value="Cpn60/GroEL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02348">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF000592">
        <property type="entry name" value="PRK00013.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009487">
        <property type="entry name" value="PRK12849.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009488">
        <property type="entry name" value="PRK12850.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009489">
        <property type="entry name" value="PRK12851.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45633">
        <property type="entry name" value="60 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00298">
        <property type="entry name" value="CHAPERONIN60"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0143">Chaperone</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="471"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="586"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="479"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="590"/>
            <end position="612"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="618" mass="66202" checksum="ABF69E6E77B8CF39" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWL0</accession>
    <name>Q5CWL0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">5kows transcription initiation protein SPT5</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_4650</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPT5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90170.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627794.1">
        <property type="nucleotide sequence ID" value="XM_627794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWL0"/>
    <dbReference type="FunCoup" id="Q5CWL0">
        <property type="interactions" value="421"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWL0"/>
    <dbReference type="GeneID" id="3375915"/>
    <dbReference type="KEGG" id="cpv:cgd6_4650"/>
    <dbReference type="InParanoid" id="Q5CWL0"/>
    <dbReference type="OMA" id="YPVGYMN"/>
    <dbReference type="OrthoDB" id="28901at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032044">
        <property type="term" value="C:DSIF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032784">
        <property type="term" value="P:regulation of DNA-templated transcription elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06081">
        <property type="entry name" value="KOW_Spt5_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06084">
        <property type="entry name" value="KOW_Spt5_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09888">
        <property type="entry name" value="NGN_Euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.940">
        <property type="entry name" value="NusG, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005824">
        <property type="entry name" value="KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041973">
        <property type="entry name" value="KOW_Spt5_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041977">
        <property type="entry name" value="KOW_Spt5_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057936">
        <property type="entry name" value="KOWx_Spt5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005100">
        <property type="entry name" value="NGN-domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036735">
        <property type="entry name" value="NGN_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039385">
        <property type="entry name" value="NGN_Euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039659">
        <property type="entry name" value="SPT5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017071">
        <property type="entry name" value="TF_Spt5_eukaryote"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125">
        <property type="entry name" value="SUPPRESSOR OF TY 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11125:SF7">
        <property type="entry name" value="TRANSCRIPTION ELONGATION FACTOR SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23042">
        <property type="entry name" value="KOW1_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23291">
        <property type="entry name" value="KOW4_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23037">
        <property type="entry name" value="KOWx_SPT5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03439">
        <property type="entry name" value="Spt5-NGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF036945">
        <property type="entry name" value="Spt5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00739">
        <property type="entry name" value="KOW"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="223"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="375"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="432"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="561"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="domain" description="KOW" evidence="6">
        <location>
            <begin position="664"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="619"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="724"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="731"/>
            <end position="758"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00739"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90170.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="888" mass="97300" checksum="AD0E26E4C4B7AADA" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWL2</accession>
    <name>Q5CWL2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_4630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90051.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627792.1">
        <property type="nucleotide sequence ID" value="XM_627792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWL2"/>
    <dbReference type="FunCoup" id="Q5CWL2">
        <property type="interactions" value="335"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWL2"/>
    <dbReference type="GeneID" id="3375796"/>
    <dbReference type="KEGG" id="cpv:cgd6_4630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4630"/>
    <dbReference type="InParanoid" id="Q5CWL2"/>
    <dbReference type="OMA" id="QRPHYRK"/>
    <dbReference type="OrthoDB" id="1703270at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11380">
        <property type="entry name" value="Ribosomal_S8e_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.168.20:FF:000001">
        <property type="entry name" value="40S ribosomal protein S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.168.20">
        <property type="entry name" value="Ribosomal protein S8e, subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001047">
        <property type="entry name" value="Ribosomal_eS8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042563">
        <property type="entry name" value="Ribosomal_protein_eS8_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00307">
        <property type="entry name" value="eS8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10394">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005257"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000669"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90051.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="208" mass="23497" checksum="549FE5100D62F896" modified="2007-04-03" version="1">MGISRDSRHKHRATGGRMPIVVKKRKYEMGRPASNTKLGASPRVRVVRCRGGNKKFRALRLDSGNYSWGSQGISRKARIMEVVYNASNNELVRTKTLVKNAIVVIDATPFRQFYLQRYGVELGRRKNADEKSDEKDAQKASGHLLATRKARLMNNVIDPLVEEQFGIGRLLACVSSRPGQCGRCDGYILEGKELEFYKKKLEKKKAAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWN1</accession>
    <name>Q5CWN1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP-dependent DNA helicase</fullName>
            <ecNumber evidence="11">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd6_4420</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the helicase family. RecQ subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="11"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90038.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627773.1">
        <property type="nucleotide sequence ID" value="XM_627773.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWN1"/>
    <dbReference type="SMR" id="Q5CWN1"/>
    <dbReference type="STRING" id="353152.Q5CWN1"/>
    <dbReference type="GeneID" id="3375783"/>
    <dbReference type="KEGG" id="cpv:cgd6_4420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4420"/>
    <dbReference type="InParanoid" id="Q5CWN1"/>
    <dbReference type="OMA" id="YENCVED"/>
    <dbReference type="OrthoDB" id="10261556at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009378">
        <property type="term" value="F:four-way junction helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17920">
        <property type="entry name" value="DEXHc_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18794">
        <property type="entry name" value="SF2_C_RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000296">
        <property type="entry name" value="ATP-dependent DNA helicase RecQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000340">
        <property type="entry name" value="Bloom syndrome, RecQ helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.80">
        <property type="entry name" value="HRDC domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004589">
        <property type="entry name" value="DNA_helicase_ATP-dep_RecQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010997">
        <property type="entry name" value="HRDC-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002121">
        <property type="entry name" value="HRDC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044876">
        <property type="entry name" value="HRDC_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032284">
        <property type="entry name" value="RecQ_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00614">
        <property type="entry name" value="recQ_fam"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710">
        <property type="entry name" value="DNA HELICASE RECQ FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13710:SF153">
        <property type="entry name" value="RECQ-LIKE DNA HELICASE BLM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00570">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16124">
        <property type="entry name" value="RecQ_Zn_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00341">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47819">
        <property type="entry name" value="HRDC-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50967">
        <property type="entry name" value="HRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 11 15" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 11" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0413">Isomerase</keyword>
    <keyword evidence="3 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="246"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="458"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="domain" description="HRDC" evidence="12">
        <location>
            <begin position="879"/>
            <end position="961"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU364117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK90038.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="990" mass="113106" checksum="7F84EABD29534764" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWT2</accession>
    <name>Q5CWT2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">SET domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627722.1">
        <property type="nucleotide sequence ID" value="XM_627722.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWT2"/>
    <dbReference type="GeneID" id="3375739"/>
    <dbReference type="KEGG" id="cpv:cgd6_3840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3840"/>
    <dbReference type="InParanoid" id="Q5CWT2"/>
    <dbReference type="OMA" id="HRTANLI"/>
    <dbReference type="OrthoDB" id="341421at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016279">
        <property type="term" value="F:protein-lysine N-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1410.10">
        <property type="entry name" value="set domain protein methyltransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050600">
        <property type="entry name" value="SETD3_SETD6_MTase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13271">
        <property type="entry name" value="UNCHARACTERIZED PUTATIVE METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="214"/>
            <end position="545"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="719" mass="83186" checksum="CAE776A793492F61" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWY9</accession>
    <name>Q5CWY9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627665.1">
        <property type="nucleotide sequence ID" value="XM_627665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWY9"/>
    <dbReference type="FunCoup" id="Q5CWY9">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="GeneID" id="3375894"/>
    <dbReference type="KEGG" id="cpv:cgd6_3200"/>
    <dbReference type="InParanoid" id="Q5CWY9"/>
    <dbReference type="OMA" id="YENKNWR"/>
    <dbReference type="OrthoDB" id="342740at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="62"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="178"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="353"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="414" mass="48879" checksum="80C0186FBD0C10AC" modified="2005-04-12" version="1" fragment="single">IWSKFTIIQDEYQKEKEIIVGVRKSIETMKNSTYFEVKKNFKEIKDLISDYMNETSRLSSKEEDYKSQLKLIEDDIAELSSRLITNEEELKEKVGMKINCDRNLSNVIKKNEELSHELMIKQLNTVALESCSKMRRKEIINLEDTLKELEDNTRCILGMMSMENTAILSVRTEYAQINEQKKKMVKSLETERDKLIRAGKDTKIKIEQLNKKILINKKQILQLKSEESKKIEIIEKLNEQLISIKGKNTIEDSNLNKIQSTMNAIKIQLSGLDEKIRVIKYLWETKRDFNIHEVFDDEEIIMEANNKLNDSHFNISVYIRENGELMITKNSLIDEIEIIKQKLSEQDLNSNKIQEIQIEINEKINKARMLNSELLKKQRELSNTEDQILESKQRLLKIKNILKNISKKRYEEER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWZ4</accession>
    <name>Q5CWZ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein with sec7+ TBC domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_3140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627660.1">
        <property type="nucleotide sequence ID" value="XM_627660.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWZ4"/>
    <dbReference type="GeneID" id="3375689"/>
    <dbReference type="KEGG" id="cpv:cgd6_3140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3140"/>
    <dbReference type="InParanoid" id="Q5CWZ4"/>
    <dbReference type="OMA" id="MLENATH"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF402">
        <property type="entry name" value="MIP16918P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="3">
        <location>
            <begin position="278"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="911"/>
            <end position="1212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="160"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="205"/>
            <end position="223"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1291" mass="147627" checksum="C73159D14F4A6A45" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX50</accession>
    <name>Q5CX50_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_2500</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627604.1">
        <property type="nucleotide sequence ID" value="XM_627604.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3376134"/>
    <dbReference type="KEGG" id="cpv:cgd6_2500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2500"/>
    <dbReference type="InParanoid" id="Q5CX50"/>
    <dbReference type="OMA" id="TEYISHT"/>
    <dbReference type="OrthoDB" id="341150at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1484" mass="172048" checksum="B9AA531909A70902" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX93</accession>
    <name>Q5CX93_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89860.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627561.1">
        <property type="nucleotide sequence ID" value="XM_627561.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3376072"/>
    <dbReference type="KEGG" id="cpv:cgd6_2000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2000"/>
    <dbReference type="InParanoid" id="Q5CX93"/>
    <dbReference type="OMA" id="SAMINEM"/>
    <dbReference type="OrthoDB" id="342554at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1444"/>
            <end position="1462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89860.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1676" mass="195128" checksum="C838EF84CD0FC697" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXE6</accession>
    <name>Q5CXE6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hus1-like mitotic and DNA damage checkpoint protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_1370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89817.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627508.1">
        <property type="nucleotide sequence ID" value="XM_627508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXE6"/>
    <dbReference type="STRING" id="353152.Q5CXE6"/>
    <dbReference type="GeneID" id="3376010"/>
    <dbReference type="KEGG" id="cpv:cgd6_1370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1370"/>
    <dbReference type="InParanoid" id="Q5CXE6"/>
    <dbReference type="OMA" id="YIVESKH"/>
    <dbReference type="OrthoDB" id="337750at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030896">
        <property type="term" value="C:checkpoint clamp complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035861">
        <property type="term" value="C:site of double-strand break"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044778">
        <property type="term" value="P:meiotic DNA integrity checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033314">
        <property type="term" value="P:mitotic DNA replication checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007150">
        <property type="entry name" value="HUS1/Mec3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900:SF0">
        <property type="entry name" value="CHECKPOINT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12900">
        <property type="entry name" value="MITOTIC AND DNA DAMAGE CHECKPOINT PROTEIN HUS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04005">
        <property type="entry name" value="Hus1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89817.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="336" mass="38739" checksum="FB3965F1009286C8" modified="2007-04-03" version="1">MRFKATLLQRKSSILLECIQGFVKMMKGLPNKQNSRFYIKFEKNSLILLLTSYCNWDEQIADVSCRLKYEDVFFSEPVLESKNENIIGISLNPEALILPLRSSILAKETTLRLSKRDSQNVLSFSMIIETKKMSTFQLTHDCKVDVLKSKITNELIPLGEDGKRFGSEIPNTHFSLPPPKSLLRLFEKMKLVDSKYVEIEIVQDYNNEAQNNHDEGSKSQTCHFICTSDKSLNSTVSIKTFFNNCIVFHTENYDESRMIISQEQNRRTDEKELFRVFATFDINHLMSVLQFSTTISDSYCVATITQNKFLSMLIFFPNIESQISIFLASVNTKTTE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXF9</accession>
    <name>Q5CXF9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_1240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89806.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627495.1">
        <property type="nucleotide sequence ID" value="XM_627495.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXF9"/>
    <dbReference type="GeneID" id="3376038"/>
    <dbReference type="KEGG" id="cpv:cgd6_1240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1240"/>
    <dbReference type="InParanoid" id="Q5CXF9"/>
    <dbReference type="OMA" id="ECIFETS"/>
    <dbReference type="OrthoDB" id="339236at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89806.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="155" mass="18143" checksum="86F2C618CAEAE623" modified="2005-04-12" version="1">MKRRQGIKLETPNDLDSNTWDELCTSLYPSWCSQNRGIILAKKNYEAQEWNVKTSLHPNIEKFFFEEIQEFFDKSSEEKKGLSIDLWGKQFNIKNEEVDSNSSDVIWLIDSLNTFGLAITLFEDISVVFFYEVKNKGDINEEKILSFIKLIAKMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXH8</accession>
    <name>Q5CXH8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNAse P Rpr2/Rpp21 subunit domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_1040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the eukaryotic/archaeal RNase P protein component 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89788.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627476.1">
        <property type="nucleotide sequence ID" value="XM_627476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXH8"/>
    <dbReference type="STRING" id="353152.Q5CXH8"/>
    <dbReference type="GeneID" id="3376098"/>
    <dbReference type="KEGG" id="cpv:cgd6_1040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1040"/>
    <dbReference type="InParanoid" id="Q5CXH8"/>
    <dbReference type="OMA" id="MSHEIHE"/>
    <dbReference type="OrthoDB" id="128536at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005655">
        <property type="term" value="C:nucleolar ribonuclease P complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007175">
        <property type="entry name" value="Rpr2/Snm1/Rpp21"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742:SF0">
        <property type="entry name" value="RIBONUCLEASE P PROTEIN SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14742">
        <property type="entry name" value="RIBONUCLEASE P SUBUNIT P21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04032">
        <property type="entry name" value="Rpr2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00038402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89788.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="139" mass="16555" checksum="23C34C05E870F324" modified="2007-04-03" version="1">MEQNSQPDSEKKKEGMSVAPAYHRMNFLLQVSQQYALVSNELSRYCYSLAREISRKKLARIDPDSRRLWCKRCNTHFIPGITCEFILEDQIISGGNNNNNKKFVKTNIFNRCNYCNWKKRHTYKVFDEFEDEEKNMIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXL1</accession>
    <name>Q5CXL1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Mic1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89761.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627443.1">
        <property type="nucleotide sequence ID" value="XM_627443.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXL1"/>
    <dbReference type="GeneID" id="3376051"/>
    <dbReference type="KEGG" id="cpv:cgd6_640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_640"/>
    <dbReference type="InParanoid" id="Q5CXL1"/>
    <dbReference type="OMA" id="FENMNED"/>
    <dbReference type="OrthoDB" id="264532at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031902">
        <property type="term" value="C:late endosome membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035658">
        <property type="term" value="C:Mon1-Ccz1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010506">
        <property type="term" value="P:regulation of autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040371">
        <property type="entry name" value="RMC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897">
        <property type="entry name" value="COLON CANCER-ASSOCIATED PROTEIN MIC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12897:SF4">
        <property type="entry name" value="REGULATOR OF MON1-CCZ1 COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="782"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="788"/>
            <end position="797"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89761.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="914" mass="107118" checksum="9C5E8CDEB5AF1084" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXN7</accession>
    <name>Q5CXN7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_5500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628693.1">
        <property type="nucleotide sequence ID" value="XM_628691.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372157"/>
    <dbReference type="KEGG" id="cpv:cgd7_5500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5500"/>
    <dbReference type="InParanoid" id="Q5CXN7"/>
    <dbReference type="OMA" id="WWVESIT"/>
    <dbReference type="OrthoDB" id="337729at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254350" evidence="1">
        <location>
            <begin position="21"/>
            <end position="1483"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1483" mass="166277" checksum="E8B87CB39CE1B1E2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXT5</accession>
    <name>Q5CXT5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Beta'-coat protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">cgd7_5010</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628645.1">
        <property type="nucleotide sequence ID" value="XM_628643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXT5"/>
    <dbReference type="FunCoup" id="Q5CXT5">
        <property type="interactions" value="469"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXT5"/>
    <dbReference type="GeneID" id="3371953"/>
    <dbReference type="KEGG" id="cpv:cgd7_5010"/>
    <dbReference type="InParanoid" id="Q5CXT5"/>
    <dbReference type="OMA" id="YVDYYPQ"/>
    <dbReference type="OrthoDB" id="2150324at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd22947">
        <property type="entry name" value="Coatomer_WDAD_beta-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000016">
        <property type="entry name" value="Coatomer alpha subunit, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.470">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006692">
        <property type="entry name" value="Beta-prop_COPA/B_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050844">
        <property type="entry name" value="Coatomer_complex_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056176">
        <property type="entry name" value="TPR_COPA_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876">
        <property type="entry name" value="COATOMER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19876:SF2">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04053">
        <property type="entry name" value="B-prop_COPA_B_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23953">
        <property type="entry name" value="TPR_COPA_B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0653">Protein transport</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="5 13" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="99"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="142"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="195"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="13">
        <location>
            <begin position="239"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B second beta-propeller" evidence="15">
        <location>
            <begin position="356"/>
            <end position="612"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="16">
        <location>
            <begin position="631"/>
            <end position="705"/>
        </location>
    </feature>
    <feature type="domain" description="COPA/B TPR" evidence="16">
        <location>
            <begin position="739"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="983"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="1002"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="14">
        <location>
            <begin position="1028"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1042"/>
            <end position="1067"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="1068"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="14">
        <location>
            <begin position="1104"/>
            <end position="1116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="1142"/>
            <end position="1157"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00025536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00032920"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF04053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF23953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAK90650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1157" mass="131942" checksum="BCA753503C24B853" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXU5</accession>
    <name>Q5CXU5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Conserved 3 transmembrane domain membrane associated RING finger domain (Shared by plants and apicomplexans)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_4910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628635.1">
        <property type="nucleotide sequence ID" value="XM_628633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXU5"/>
    <dbReference type="STRING" id="353152.Q5CXU5"/>
    <dbReference type="GeneID" id="3372226"/>
    <dbReference type="KEGG" id="cpv:cgd7_4910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4910"/>
    <dbReference type="InParanoid" id="Q5CXU5"/>
    <dbReference type="OMA" id="NDIFTRW"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010182">
        <property type="term" value="P:sugar mediated signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044793">
        <property type="entry name" value="SIS3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47179">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47179:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SIS3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="36"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="78"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="123"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="212"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="264"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="280"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="295"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="311" mass="35469" checksum="04B9D81D1A2BC68D" modified="2005-04-12" version="1">MTGFGINDAILGLAFMYSSADLISQWDSFSTCCHPIQLWLIISYITIIAFRVIHYVSNYLSEGSDDVLPYSSTSGIPFWLNLSVVCLIFPFFLSWTVVGTVWLKNIESKTPQCLAGNGSSHPWFLIFWLVLCYIWIVAYTAFISISIFFEFRVRRAEEDLLLLENDEVMRRWGRLRLLADYGIHFIRHGLTPVEVAALPLSKVKVEEFNDPCSICIEDFKLNEEIRTLPACGHSFHKGCIDAWLLRNAICPNCKTLVRYGKTETGTSPCRGSSHIPDHQNSSYRSNSRDSVSTMDTRREAGRERSYDSLMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXU7</accession>
    <name>Q5CXU7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal peptide plus GPI anchored membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_4880</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628633.1">
        <property type="nucleotide sequence ID" value="XM_628631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXU7"/>
    <dbReference type="GeneID" id="3372192"/>
    <dbReference type="KEGG" id="cpv:cgd7_4880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4880"/>
    <dbReference type="InParanoid" id="Q5CXU7"/>
    <dbReference type="OMA" id="XSTASSA"/>
    <dbReference type="OrthoDB" id="344371at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253954" evidence="3">
        <location>
            <begin position="22"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="300"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="49"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="252"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="91"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="125"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="140"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="257"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="328" mass="36800" checksum="8C3C7C94C071F31F" modified="2005-04-12" version="1">MKSIFQLIFLATFFLFGILNALQIHESVTSASVDNSLLGNEVFDMDSEVETKVDEKTNSQTDNKMTTEFDYDESKSSNSDMSKQTGTSKDTNTSSQTYNSSSESDIYENESTASTQDFETYQSMDKTTTGTTTSTDKSYDQTSNVDTTVQATTMPKQTSKVMRADQTNSYKTVTPMGTSDDLEIEDYTVGKNTYNKSDDGYQKDVTKYQSTSTTPTETSTTKHVTFDGEGFLKAVSKLVNIRKRVNTGNDSVATTKDYQKSVTRDTTDSTKKPTDNQGDHDNDDEDDQESFFDKYGIPEYVFWIIVYTVPVLFVLLLCLTSYCCCCRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXW6</accession>
    <name>Q5CXW6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Secreted mucin like glycoprotein, signal peptide, thr stretch</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4660</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628614.1">
        <property type="nucleotide sequence ID" value="XM_628612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXW6"/>
    <dbReference type="GeneID" id="3372189"/>
    <dbReference type="KEGG" id="cpv:cgd7_4660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4660"/>
    <dbReference type="InParanoid" id="Q5CXW6"/>
    <dbReference type="OMA" id="TIIYSQE"/>
    <dbReference type="OrthoDB" id="343585at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253957" evidence="2">
        <location>
            <begin position="21"/>
            <end position="465"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="131"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="131"/>
            <end position="167"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="465" mass="51980" checksum="CE00F45A33D3A05B" modified="2005-04-12" version="1">MARMLLKNFIIFLLSALCLAFVPNFAVLGAENETGSYQTKSLSMESFTSSSSSFSSSYQFQSSTTTPATECSECPDSMFPEKSEDGEKDSQSPIFLDELYSKYYEFKSSQEGSSIDESSSDQIVLVTPPVTTPVATPIPAPRTTTTTTTTTTTTTTTTTTTTTTSPTESPKFPLDDIIVSVSPIDESFLYSPKNENSKYFNECIGQDCMELAAVGSKVSDLVNIFEQGPSDFAKPRGESSRSEVAKLVNVFEKFDDEDQFEPKVVSPTLNALREGTLEYLQLPEKVEPEVSHFITTREVVPKMALKFESLKYEDPKNEIDDEYVATSLVEVTDRSSEKQLRSRVTKEAVPKLIEAWESLRKDEELIPLRSRKTGYTFKEFCDDKIKKCSDSLTEKPALIEGIQFPPAEYDIVEVQPIKKHKIKIRAVSNNPESAKEELKKSAKKLGLDLEDEKIKISKLRGYKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXY3</accession>
    <name>Q5CXY3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L6</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_4460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628597.1">
        <property type="nucleotide sequence ID" value="XM_628595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXY3"/>
    <dbReference type="FunCoup" id="Q5CXY3">
        <property type="interactions" value="429"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXY3"/>
    <dbReference type="GeneID" id="3372176"/>
    <dbReference type="KEGG" id="cpv:cgd7_4460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4460"/>
    <dbReference type="InParanoid" id="Q5CXY3"/>
    <dbReference type="OMA" id="KWYNADD"/>
    <dbReference type="OrthoDB" id="2436667at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd13156">
        <property type="entry name" value="KOW_RPL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.30:FF:000014">
        <property type="entry name" value="60S ribosomal protein L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000915">
        <property type="entry name" value="60S_ribosomal_eL6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041997">
        <property type="entry name" value="Ribosomal_eL6_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10715:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01159">
        <property type="entry name" value="Ribosomal_L6e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="184" mass="20740" checksum="E0417D3C45C7B8B2" modified="2005-04-12" version="1">MTEKIQLYKPRDRVKVTLRRKYSSRRKASVVAPKLRSSLQPGVVCILLAGPYKGKRVVMLKALPSGLVVVTGPYALNGVPVRRVNPAYIIATSTKVDVSKADVSKFTDEYFKVDRSKLKKSKDTFMDQGEETKVNRVVSEERKKTQQALDASIIPSIQSNPLMMSYLKTRFTLTSGMFPHKLKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXZ0</accession>
    <name>Q5CXZ0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nuclear migration protein nudC</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Nuclear distribution protein C homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_4390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the nudC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90643.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628590.1">
        <property type="nucleotide sequence ID" value="XM_628588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXZ0"/>
    <dbReference type="FunCoup" id="Q5CXZ0">
        <property type="interactions" value="45"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXZ0"/>
    <dbReference type="GeneID" id="3371946"/>
    <dbReference type="KEGG" id="cpv:cgd7_4390"/>
    <dbReference type="InParanoid" id="Q5CXZ0"/>
    <dbReference type="OMA" id="TMEWWAT"/>
    <dbReference type="OrthoDB" id="416217at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06467">
        <property type="entry name" value="p23_NUDC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.40.790:FF:000001">
        <property type="entry name" value="Nuclear migration protein nudC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007052">
        <property type="entry name" value="CS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008978">
        <property type="entry name" value="HSP20-like_chaperone"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037898">
        <property type="entry name" value="NudC_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025934">
        <property type="entry name" value="NudC_N_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356:SF3">
        <property type="entry name" value="NUCLEAR MIGRATION PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12356">
        <property type="entry name" value="NUCLEAR MOVEMENT PROTEIN NUDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04969">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14050">
        <property type="entry name" value="Nudc_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49764">
        <property type="entry name" value="HSP20-like chaperones"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51203">
        <property type="entry name" value="CS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CS" evidence="8">
        <location>
            <begin position="146"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="78"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="78"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="107"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00030427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90643.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="312" mass="35866" checksum="0F831D51B64F9FC7" modified="2005-04-12" version="1" fragment="single">KALSRMDERFDSLLINLAQSANGIENFLDVIFGFLLRKTDFFTAMNQGEEEKILMKYFRKYQALSADKRREEKRLMMEREEERKKKIEEQKRREEEELKNMSTKSVPKIEEVFSDDEKGQPATKTNEKLGDEEESDTEAPPPGNGGSTDKYTWTQTLGTVEVLIDTIPGIKSRDCNINIKTNRLKVVVKGEVIIDGELNSKVKPDDCLWSIIDGKTIQIVLEKQENINWWSCVIKGDQEIDTTKIVPENSKLSDLDPETRATVEKMMFDQRQKAMGLPTSDNLKQHELLEKFKAAHPEMDFSQAKINYGSGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYD3</accession>
    <name>Q5CYD3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_2780</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90293.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628447.1">
        <property type="nucleotide sequence ID" value="XM_628445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYD3"/>
    <dbReference type="GeneID" id="3372266"/>
    <dbReference type="KEGG" id="cpv:cgd7_2780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2780"/>
    <dbReference type="InParanoid" id="Q5CYD3"/>
    <dbReference type="OrthoDB" id="341551at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="712"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90293.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="818" mass="94540" checksum="40889BE1A8EE890B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYK7</accession>
    <name>Q5CYK7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Membrane protein with multiple cysteines at the N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_1960</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628373.1">
        <property type="nucleotide sequence ID" value="XM_628371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYK7"/>
    <dbReference type="STRING" id="353152.Q5CYK7"/>
    <dbReference type="GeneID" id="3371881"/>
    <dbReference type="KEGG" id="cpv:cgd7_1960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1960"/>
    <dbReference type="InParanoid" id="Q5CYK7"/>
    <dbReference type="OMA" id="VCEHECS"/>
    <dbReference type="OrthoDB" id="343665at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34660">
        <property type="entry name" value="MYB-LIKE PROTEIN X"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34660:SF3">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254552" evidence="3">
        <location>
            <begin position="28"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="362"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="405"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="126"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="335"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="520"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="579" mass="62374" checksum="10727990DEE7BAA3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="147" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYL9</accession>
    <name>Q5CYL9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">cgd7_1840</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="22" key="2">
        <citation type="submission" date="2007-06" db="PDB data bank">
            <title>Cryptosporidium parvum calcium dependent protein kinase cgd7_1840.</title>
            <authorList>
                <person name="Lunin V.V."/>
                <person name="Wernimont A.K."/>
                <person name="Lew J."/>
                <person name="Wasney G."/>
                <person name="Kozieradzki I."/>
                <person name="Vedadi M."/>
                <person name="Bochkarev A."/>
                <person name="Arrowsmith C.H."/>
                <person name="Sundstrom M."/>
                <person name="Weigelt J."/>
                <person name="Edwards A.E."/>
                <person name="Hui R."/>
                <person name="Artz J."/>
                <person name="Amani M."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.30 ANGSTROMS) OF 197-472</scope>
        <scope>PHOSPHORYLATION AT SER-408</scope>
    </reference>
    <reference evidence="23" key="3">
        <citation type="submission" date="2008-10" db="PDB data bank">
            <title>Crystal structure of Cryptosporidium parvum calcium dependent protein kinase cgd7_1840 in presence of indirubin E804.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Lew J."/>
                <person name="Wasney G."/>
                <person name="Kozieradzki I."/>
                <person name="Cossar D."/>
                <person name="Vedadi M."/>
                <person name="Bochkarev A."/>
                <person name="Arrowsmith C.H."/>
                <person name="Sundstrom M."/>
                <person name="Weigelt J."/>
                <person name="Edwards A.M."/>
                <person name="Hui R."/>
                <person name="Artz J.D."/>
                <person name="Amani M."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.84 ANGSTROMS) OF 197-472</scope>
        <scope>PHOSPHORYLATION AT SER-408</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="2">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="12">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628361.1">
        <property type="nucleotide sequence ID" value="XM_628359.1"/>
    </dbReference>
    <dbReference type="PDB" id="2QG5">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.30 A"/>
        <property type="chains" value="A/B/D=197-472"/>
    </dbReference>
    <dbReference type="PDB" id="3F3Z">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.84 A"/>
        <property type="chains" value="A=197-472"/>
    </dbReference>
    <dbReference type="PDBsum" id="2QG5"/>
    <dbReference type="PDBsum" id="3F3Z"/>
    <dbReference type="AlphaFoldDB" id="Q5CYL9"/>
    <dbReference type="SMR" id="Q5CYL9"/>
    <dbReference type="STRING" id="353152.Q5CYL9"/>
    <dbReference type="BindingDB" id="Q5CYL9"/>
    <dbReference type="ChEMBL" id="CHEMBL4295844"/>
    <dbReference type="GeneID" id="3371745"/>
    <dbReference type="KEGG" id="cpv:cgd7_1840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1840"/>
    <dbReference type="InParanoid" id="Q5CYL9"/>
    <dbReference type="OMA" id="CMELCAG"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CYL9"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05467">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="22 23" id="KW-0002">3D-structure</keyword>
    <keyword evidence="11 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0106">Calcium</keyword>
    <keyword evidence="9 20" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="CBM20" evidence="19">
        <location>
            <begin position="1"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="17">
        <location>
            <begin position="206"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="504"/>
            <end position="539"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="575"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="18">
        <location>
            <begin position="616"/>
            <end position="651"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="151"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="22 23">
        <location>
            <position position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EAK90225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PDB" id="2QG5"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PDB" id="3F3Z"/>
        </source>
    </evidence>
    <sequence length="676" mass="77553" checksum="6423C470C3FB5087" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYP1</accession>
    <name>Q5CYP1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">ribonuclease Z</fullName>
            <ecNumber evidence="4">3.1.26.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_1580</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.</text>
            <dbReference type="EC" id="3.1.26.11"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase Z family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.11" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628339.1">
        <property type="nucleotide sequence ID" value="XM_628337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYP1"/>
    <dbReference type="FunCoup" id="Q5CYP1">
        <property type="interactions" value="300"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYP1"/>
    <dbReference type="GeneID" id="3372254"/>
    <dbReference type="KEGG" id="cpv:cgd7_1580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1580"/>
    <dbReference type="InParanoid" id="Q5CYP1"/>
    <dbReference type="OMA" id="INYICQL"/>
    <dbReference type="OrthoDB" id="527344at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042781">
        <property type="term" value="F:3'-tRNA processing endoribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990180">
        <property type="term" value="P:mitochondrial tRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001279">
        <property type="entry name" value="Metallo-B-lactamas"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047151">
        <property type="entry name" value="RNZ2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027794">
        <property type="entry name" value="tRNase_Z_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12553:SF49">
        <property type="entry name" value="ZINC PHOSPHODIESTERASE ELAC PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00753">
        <property type="entry name" value="Lactamase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13691">
        <property type="entry name" value="Lactamase_B_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56281">
        <property type="entry name" value="Metallo-hydrolase/oxidoreductase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0540">Nuclease</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNase Z endonuclease" evidence="12">
        <location>
            <begin position="17"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="domain" description="Metallo-beta-lactamase" evidence="11">
        <location>
            <begin position="481"/>
            <end position="547"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000402"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00753"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF13691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK90208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="821" mass="94845" checksum="C4F653FCA8F93399" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYR8</accession>
    <name>Q5CYR8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_1270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628312.1">
        <property type="nucleotide sequence ID" value="XM_628310.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYR8"/>
    <dbReference type="GeneID" id="3371856"/>
    <dbReference type="KEGG" id="cpv:cgd7_1270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1270"/>
    <dbReference type="InParanoid" id="Q5CYR8"/>
    <dbReference type="OMA" id="NIANQWI"/>
    <dbReference type="OrthoDB" id="341969at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1205"/>
            <end position="1227"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="4112"/>
            <end position="4136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="146"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="178"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="197"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="4112"/>
            <end position="4124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="4157" mass="472298" checksum="AC29A21346430672" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYW9</accession>
    <name>Q5CYW9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">PASILLA splice variant 3-like 2KH domains, transmembrane domain at C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_720</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628261.1">
        <property type="nucleotide sequence ID" value="XM_628259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYW9"/>
    <dbReference type="FunCoup" id="Q5CYW9">
        <property type="interactions" value="87"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYW9"/>
    <dbReference type="GeneID" id="3372013"/>
    <dbReference type="KEGG" id="cpv:cgd7_720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_720"/>
    <dbReference type="InParanoid" id="Q5CYW9"/>
    <dbReference type="OrthoDB" id="441329at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="107"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="364" mass="41328" checksum="C5EA4956FBD18C0B" modified="2005-04-12" version="1">MVNSSNMERTNYINMQSDEEQIIFVKLLISDKAANRILSNSGSILKKIKQVNHVFILVSGTNKYFPGTNYRVATLEGNEKNVNETMEVLDFLLKNNKDDGQEGLKNYEYNIRLAVPRSVIGSIIGIKGEFISHVRTATSAHINISPIFVTSEKACNERIITISGSNSNQVIHAFIILTKKVNSSPEGRSCKSVIYRRADFFRRKNHKTEHEKVDPLLSSQLEEMKNVLNENPINSAYEVESRSLEIKERPKLNFKTTSKGRWSEQVDLLAREEDKSLEKLGSELKQVRIIQKGLIEGAQINISQKTELANDDNKMQENLAEKLYEAPSKTVQERIPTNLFIISFLALITGAFFLQYISSEVIRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="119" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYZ7</accession>
    <name>Q5CYZ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein with DEXDc plus ring plus HELICc possible SNF2 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_420</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90533.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628233.1">
        <property type="nucleotide sequence ID" value="XM_628231.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYZ7"/>
    <dbReference type="GeneID" id="3371908"/>
    <dbReference type="KEGG" id="cpv:cgd7_420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_420"/>
    <dbReference type="InParanoid" id="Q5CYZ7"/>
    <dbReference type="OMA" id="ASHVHNI"/>
    <dbReference type="OrthoDB" id="423559at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052583">
        <property type="entry name" value="ATP-helicase/E3_Ub-Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45865">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE SHPRH FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="1738"/>
            <end position="1786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="215"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="278"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="881"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1575"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="896"/>
            <end position="912"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="922"/>
            <end position="932"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="1579"/>
            <end position="1602"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90533.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2042" mass="236641" checksum="DF86FC0948E4E6AB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYZ8</accession>
    <name>Q5CYZ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628232.1">
        <property type="nucleotide sequence ID" value="XM_628230.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYZ8"/>
    <dbReference type="GeneID" id="3371907"/>
    <dbReference type="KEGG" id="cpv:cgd7_400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_400"/>
    <dbReference type="InParanoid" id="Q5CYZ8"/>
    <dbReference type="OMA" id="SCIKANI"/>
    <dbReference type="OrthoDB" id="337295at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254674" evidence="1">
        <location>
            <begin position="21"/>
            <end position="347"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="347" mass="38580" checksum="57549424D1E567C6" modified="2005-04-12" version="1">MKFCQNVLYMISIIILVVRGAPTLNVRNPGEHGHPDSMITTSTTKATHTLKSNNQSTSEELLSMKSLQNEPNCENAVFPSEVFASQPRDDKVYIKPSTIPESGFTRAGLTKFTSAFGIHILGDYRVPDDKLSYLTELLASVLDNDQDGLVDATQNTILDTIRSSNAMMVILSGNEESVDKLLDPHEGLPPEYSCMMFLLVEQAKNIIRGGPHQKNCPQDLDRVNDRGLGFVVDFISQAAYPVTFSLNEESSMRMENLYNSALRKGWFLPQNIPVANNELCDEDCKRLSFQSWLATSILDQDKCSCIKANVFKLCTSEEIRNISPDDFAYFASALKRPTAYSSPAIIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPR1</accession>
    <name>A3FPR1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Rablib</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_4380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388407.1">
        <property type="nucleotide sequence ID" value="XM_001388370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPR1"/>
    <dbReference type="STRING" id="353152.A3FPR1"/>
    <dbReference type="GeneID" id="3371809"/>
    <dbReference type="KEGG" id="cpv:cgd7_4380"/>
    <dbReference type="InParanoid" id="A3FPR1"/>
    <dbReference type="OMA" id="EIYNNRM"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000274">
        <property type="entry name" value="ras-related protein RABA5a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004635"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="198" mass="22391" checksum="B7AD3B8AD6AA2E77" modified="2007-04-03" version="1" fragment="single">MGSSPDEYDHLYKIILVGDATVGKTHLLSRYTRDALPKTPQPTIGVEFATRTVPLSIGGTVKAQIWDTAGQERYRAITRAHYRRSVGALLVYDITRKSSFLNASKWLEDIKQNSEPDIVVMLVGNKLDLVEKDPSKREVPFDIAANFAQENNLFFSEASAVTRCNVKHIFEHLLQEVYNQKMKDNSSNLDMNGKFIKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPX1</accession>
    <name>A3FPX1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">mRNA export protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_4610</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388350.1">
        <property type="nucleotide sequence ID" value="XM_001388313.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPX1"/>
    <dbReference type="STRING" id="353152.A3FPX1"/>
    <dbReference type="GeneID" id="3375975"/>
    <dbReference type="KEGG" id="cpv:cgd6_4610"/>
    <dbReference type="InParanoid" id="A3FPX1"/>
    <dbReference type="OMA" id="EAMDQSI"/>
    <dbReference type="OrthoDB" id="256303at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10971">
        <property type="entry name" value="MRNA EXPORT FACTOR AND BUB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="94"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="238"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="333" mass="37272" checksum="F03EBB23AA3C9FCC" modified="2007-04-03" version="1" fragment="single">MNSSLLAASSWDKSVTVWEVQHMGGNSVNTRFGKFLISPKVFNDLLIVFIGASFQHSAPVLDCAISSDSRYLFSGGCDNELKMHDMSSRQSQTIGRHDAPISNIFWCDEQKFVVTGSWDKTIKFWNGQSQNPIYSLSIPERVYAMDLKYPALVVAAADNAVYVWNLQNITPTPYKRIQTQLKLQPRSISLFPDRTGFAIGSIEGRCAIAHIEESHRDKNFPFRCHRVTSSSPDIAYSINSIDFHLQYGTFATGGSDGAIAFWDKDNKSRLTIMKTMPAPVTDIKFSPSGKLLAYSLSYDWSKGYDNTAINNSCNKVLLHVMNDEHVCPKGKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPY0</accession>
    <name>A3FPY0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutamate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.17</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Glutamyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">cgd8_790</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Glu) + L-glutamate + ATP = L-glutamyl-tRNA(Glu) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:23540"/>
            <dbReference type="Rhea" id="RHEA-COMP:9663"/>
            <dbReference type="Rhea" id="RHEA-COMP:9680"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78520"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.17"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.17" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388421.1">
        <property type="nucleotide sequence ID" value="XM_001388384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPY0"/>
    <dbReference type="FunCoup" id="A3FPY0">
        <property type="interactions" value="277"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPY0"/>
    <dbReference type="GeneID" id="3374640"/>
    <dbReference type="KEGG" id="cpv:cgd8_790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_790"/>
    <dbReference type="InParanoid" id="A3FPY0"/>
    <dbReference type="OMA" id="CPVVDSH"/>
    <dbReference type="OrthoDB" id="10250478at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017102">
        <property type="term" value="C:methionyl glutamyl tRNA synthetase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004818">
        <property type="term" value="F:glutamate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006424">
        <property type="term" value="P:glutamyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00807">
        <property type="entry name" value="GlnRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000070">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1160.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.800.10:FF:000001">
        <property type="entry name" value="Glutamine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1160.10">
        <property type="entry name" value="Glutamyl-trna Synthetase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.800.10">
        <property type="entry name" value="Glutamyl-tRNA Synthetase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.10">
        <property type="entry name" value="Ribosomal Protein L25, Chain P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02076">
        <property type="entry name" value="Glu_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050132">
        <property type="entry name" value="Gln/Glu-tRNA_Ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004526">
        <property type="entry name" value="Glu-tRNA-synth_arc/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000924">
        <property type="entry name" value="Glu/Gln-tRNA-synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020058">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_cat-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020059">
        <property type="entry name" value="Glu/Gln-tRNA-synth_Ib_codon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020061">
        <property type="entry name" value="Glu_tRNA_lig_a-bdl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020056">
        <property type="entry name" value="Rbsml_bL25/Gln-tRNA_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011035">
        <property type="entry name" value="Ribosomal_bL25/Gln-tRNA_synth"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049437">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00463">
        <property type="entry name" value="gltX_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097:SF5">
        <property type="entry name" value="GLUTAMATE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43097">
        <property type="entry name" value="GLUTAMINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00749">
        <property type="entry name" value="tRNA-synt_1c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03950">
        <property type="entry name" value="tRNA-synt_1c_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20974">
        <property type="entry name" value="tRNA-synt_1c_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00987">
        <property type="entry name" value="TRNASYNTHGLU"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50715">
        <property type="entry name" value="Ribosomal protein L25-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 12 17" id="KW-0436">Ligase</keyword>
    <keyword evidence="6 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 12" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib catalytic" evidence="14">
        <location>
            <begin position="29"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamyl/glutaminyl-tRNA synthetase class Ib anti-codon binding" evidence="15">
        <location>
            <begin position="337"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="domain" description="tRNA synthetases class I (E and Q) anti-codon binding" evidence="16">
        <location>
            <begin position="439"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="534"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="536"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048351"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363037"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF00749"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF03950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF20974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAZ51461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="555" mass="63393" checksum="4D763FA24E3E39DB" modified="2007-04-03" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPY9</accession>
    <name>A3FPY9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cyclin-dependent kinases regulatory subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_2510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the CKS family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388430.1">
        <property type="nucleotide sequence ID" value="XM_001388393.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPY9"/>
    <dbReference type="STRING" id="353152.A3FPY9"/>
    <dbReference type="GeneID" id="3374649"/>
    <dbReference type="KEGG" id="cpv:cgd8_2510"/>
    <dbReference type="InParanoid" id="A3FPY9"/>
    <dbReference type="OMA" id="WRMLGVQ"/>
    <dbReference type="OrthoDB" id="440676at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.170.10">
        <property type="entry name" value="Cyclin-dependent kinase, regulatory subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000789">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036858">
        <property type="entry name" value="Cyclin-dep_kinase_reg-sub_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23415">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASES REGULATORY SUBUNIT/60S RIBOSOME SUBUNIT BIOGENESIS PROTEIN NIP7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01111">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00296">
        <property type="entry name" value="CYCLINKINASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM01084">
        <property type="entry name" value="CKS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55637">
        <property type="entry name" value="Cell cycle regulatory proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00945">
        <property type="entry name" value="CKS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2 4" id="KW-0132">Cell division</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="86"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU311113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="86" mass="10289" checksum="BCEDCF815AE73A16" modified="2007-04-03" version="1" fragment="single">RIFYFIKWIDFDSSFEILRFFLLDLFQISKKAQAIIQSKPTGLLSEQEWRMLGVQQSRGWQHYLVHKPEPHILLFRRPLGTNPQTG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQB4</accession>
    <name>A3FQB4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Proteasome subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the proteasome complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the peptidase T1B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388136.1">
        <property type="nucleotide sequence ID" value="XM_001388099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQB4"/>
    <dbReference type="SMR" id="A3FQB4"/>
    <dbReference type="FunCoup" id="A3FQB4">
        <property type="interactions" value="287"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQB4"/>
    <dbReference type="MEROPS" id="T01.984"/>
    <dbReference type="GeneID" id="3371472"/>
    <dbReference type="KEGG" id="cpv:cgd1_420"/>
    <dbReference type="InParanoid" id="A3FQB4"/>
    <dbReference type="OMA" id="MKRDHDK"/>
    <dbReference type="OrthoDB" id="268428at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010498">
        <property type="term" value="P:proteasomal protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03758">
        <property type="entry name" value="proteasome_beta_type_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035206">
        <property type="entry name" value="Proteasome_beta2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF2">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA TYPE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51476">
        <property type="entry name" value="PROTEASOME_BETA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2 4 5" id="KW-0647">Proteasome</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="203" mass="22521" checksum="B760682F9FA29E47" modified="2007-04-03" version="1">MDSLIGIKGPDFVALASDTVAFSNVFRLSLKDDKIMEIDENKLIGVGGTLGDRMQFGEYIKCNLNLYRLRNGVQLSTTATANFTRNELAELLRSDPHNVNILIGGYTKEEGAKLYWMDELASLGNVNNAAHGYGGLLVTGILDKYYKPNITQEEALDILVKCSEELKTRFLLSQYSLFVKIVDSQGVKFIKIENGTATPVMKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQK9</accession>
    <name>A3FQK9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd4_2200</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388064.1">
        <property type="nucleotide sequence ID" value="XM_001388027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQK9"/>
    <dbReference type="FunCoup" id="A3FQK9">
        <property type="interactions" value="359"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQK9"/>
    <dbReference type="GeneID" id="3372826"/>
    <dbReference type="KEGG" id="cpv:cgd4_2200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2200"/>
    <dbReference type="InParanoid" id="A3FQK9"/>
    <dbReference type="OMA" id="THNKIAM"/>
    <dbReference type="OrthoDB" id="10255539at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030261">
        <property type="term" value="P:chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd03273">
        <property type="entry name" value="ABC_SMC2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027120">
        <property type="entry name" value="Smc2_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43977">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3" id="KW-0132">Cell division</keyword>
    <keyword evidence="7 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="5" id="KW-0498">Mitosis</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="13">
        <location>
            <begin position="549"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="239"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="461"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="754"/>
            <end position="853"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="882"/>
            <end position="944"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005231"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAZ51252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1236" mass="142216" checksum="99DA9F44F2F20739" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQM9</accession>
    <name>A3FQM9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Mitochondrial carrier protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd4_100</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAZ51235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388047.1">
        <property type="nucleotide sequence ID" value="XM_001388010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQM9"/>
    <dbReference type="GeneID" id="3372633"/>
    <dbReference type="KEGG" id="cpv:cgd4_100"/>
    <dbReference type="InParanoid" id="A3FQM9"/>
    <dbReference type="OMA" id="CISYELR"/>
    <dbReference type="OrthoDB" id="250329at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45667">
        <property type="entry name" value="S-ADENOSYLMETHIONINE MITOCHONDRIAL CARRIER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="62"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="95"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="93"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="13">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="226" mass="26072" checksum="6F63DF87EA50602F" modified="2007-04-03" version="1" fragment="single">MSESTNDLALNDILIGSSLAGFVGRLILHPFDTLKTRKQILDNLEIFNCKRVFLGKNLYSGIQISLLGGIPGTMLYFSCYEYLKRLKFKFIENRDLTNFISGFLAECVSCIIWVPVDICRERSQLDYYLKSVNGKKPFSYSDSFGKFNLRGIRHFYKGYIPTVVSFGLFSSIYFVILERLKTRQFKQDLSENKQLLLSSIVAGTLSNSRYHKFKHLITIIIIFCLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQR2</accession>
    <name>A3FQR2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">COG0237: dephospho-CoA kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAZ51213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388188.1">
        <property type="nucleotide sequence ID" value="XM_001388151.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQR2"/>
    <dbReference type="STRING" id="353152.A3FQR2"/>
    <dbReference type="GeneID" id="3372350"/>
    <dbReference type="KEGG" id="cpv:cgd2_380"/>
    <dbReference type="InParanoid" id="A3FQR2"/>
    <dbReference type="OrthoDB" id="247245at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004140">
        <property type="term" value="F:dephospho-CoA kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02022">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001977">
        <property type="entry name" value="Depp_CoAkinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695:SF46">
        <property type="entry name" value="BIFUNCTIONAL COENZYME A SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10695">
        <property type="entry name" value="DEPHOSPHO-COA KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01121">
        <property type="entry name" value="CoaE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51219">
        <property type="entry name" value="DPCK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="118" mass="13929" checksum="986FF840F4BE313C" modified="2007-04-03" version="1">MITHPRIFAATLYEIFYFRVFVLLTRFQNVKTILVSPLLFESKVFTWICSPIYVVSANREQQIKYLMDRDSCTQTLAENMIDSQMSLKTKCELADKVLWNNDSIHDLKIQIKKEFSIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQR3</accession>
    <name>A3FQR3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Synaptobrevin-like protein, possible</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_170</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the synaptobrevin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAZ51205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388294.1">
        <property type="nucleotide sequence ID" value="XM_001388257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQR3"/>
    <dbReference type="FunCoup" id="A3FQR3">
        <property type="interactions" value="203"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQR3"/>
    <dbReference type="GeneID" id="3375656"/>
    <dbReference type="KEGG" id="cpv:cgd6_170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_170"/>
    <dbReference type="InParanoid" id="A3FQR3"/>
    <dbReference type="OMA" id="RLNFFMW"/>
    <dbReference type="OrthoDB" id="248747at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14824">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15843">
        <property type="entry name" value="R-SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.50">
        <property type="entry name" value="Longin domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010908">
        <property type="entry name" value="Longin_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001388">
        <property type="entry name" value="Synaptobrevin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051097">
        <property type="entry name" value="Synaptobrevin-like_transport"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136">
        <property type="entry name" value="SNARE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21136:SF168">
        <property type="entry name" value="VESICLE-ASSOCIATED MEMBRANE PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13774">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00219">
        <property type="entry name" value="SYNAPTOBREVN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01270">
        <property type="entry name" value="Longin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50859">
        <property type="entry name" value="LONGIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50892">
        <property type="entry name" value="V_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="180"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="domain" description="Longin" evidence="10">
        <location>
            <begin position="7"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="11">
        <location>
            <begin position="115"/>
            <end position="175"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="255" mass="29725" checksum="FE356BB982A5211A" modified="2007-04-03" version="1">MSIIYSLVAKDNVVLAEYTENTGNFPSIARFLLKKINKSLNKQSYTYDIYCFHFLIYEPGVIYMAMTDRSFGLTIPYEYLLDIRSKTLPFVEMLTNPITLILNGVIYWNCPENTEYDMLANQISTIQNVLIENIDILLERGEKLDLLVSQAKNLTMESNTFRRQSYRLQQSAEWLPIKRIIMLFLAGTFILSIYIILAFNCGGLFLNNCIHKFPNNYIPEPFINNNDDDKFNEPAFREVDEFINELNTKKKPNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQS1</accession>
    <name>A3FQS1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd3_260</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAZ51204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388091.1">
        <property type="nucleotide sequence ID" value="XM_001388054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQS1"/>
    <dbReference type="STRING" id="353152.A3FQS1"/>
    <dbReference type="GeneID" id="3372326"/>
    <dbReference type="KEGG" id="cpv:cgd3_260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_260"/>
    <dbReference type="InParanoid" id="A3FQS1"/>
    <dbReference type="OMA" id="ANRESKY"/>
    <dbReference type="OrthoDB" id="343929at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="58"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="1069"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="280"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="553"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="911"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="280"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="555"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="920"/>
            <end position="945"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAZ51204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1180" mass="132492" checksum="2881E114A9635361" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPD7</accession>
    <name>Q5CPD7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tryptophan synthase</fullName>
            <ecNumber evidence="3">4.2.1.20</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd5_4560</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>(1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + L-serine = D-glyceraldehyde 3-phosphate + L-tryptophan + H2O</text>
            <dbReference type="Rhea" id="RHEA:10532"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
            <dbReference type="ChEBI" id="CHEBI:57912"/>
            <dbReference type="ChEBI" id="CHEBI:58866"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
            <dbReference type="EC" id="4.2.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 5/5.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.20" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000018">
        <property type="protein sequence ID" value="EAK87294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625304.1">
        <property type="nucleotide sequence ID" value="XM_625304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPD7"/>
    <dbReference type="SMR" id="Q5CPD7"/>
    <dbReference type="STRING" id="353152.Q5CPD7"/>
    <dbReference type="GeneID" id="3372307"/>
    <dbReference type="KEGG" id="cpv:cgd5_4560"/>
    <dbReference type="InParanoid" id="Q5CPD7"/>
    <dbReference type="OMA" id="PLTLCQN"/>
    <dbReference type="OrthoDB" id="1716816at2759"/>
    <dbReference type="UniPathway" id="UPA00035">
        <property type="reaction ID" value="UER00044"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004834">
        <property type="term" value="F:tryptophan synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd06446">
        <property type="entry name" value="Trp-synth_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1100:FF:000004">
        <property type="entry name" value="Tryptophan synthase beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1100">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00133">
        <property type="entry name" value="Trp_synth_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006653">
        <property type="entry name" value="Trp_synth_b_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006654">
        <property type="entry name" value="Trp_synth_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023026">
        <property type="entry name" value="Trp_synth_beta/beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001926">
        <property type="entry name" value="TrpB-like_PALP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036052">
        <property type="entry name" value="TrpB-like_PALP_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00263">
        <property type="entry name" value="trpB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077:SF3">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48077">
        <property type="entry name" value="TRYPTOPHAN SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00291">
        <property type="entry name" value="PALP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001413">
        <property type="entry name" value="Trp_syn_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53686">
        <property type="entry name" value="Tryptophan synthase beta subunit-like PLP-dependent enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00168">
        <property type="entry name" value="TRP_SYNTHASE_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0028">Amino-acid biosynthesis</keyword>
    <keyword evidence="7" id="KW-0057">Aromatic amino acid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="5" id="KW-0822">Tryptophan biosynthesis</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="domain" description="Tryptophan synthase beta chain-like PALP" evidence="11">
        <location>
            <begin position="99"/>
            <end position="425"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004733"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022605"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022822"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00049047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00291"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK87294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="443" mass="49422" checksum="1751C9C0BC86281C" modified="2005-04-12" version="1" fragment="single">KYFNLFLYFFYFILFYLFHFIFEEKKTIETIFFSYFKIMTDNTYLNNFPDSNGYFGKYGGKYVPEVINNAMKEIEDAYNKISKSEDFINELKKIRKEFQGRPTPIYYAKNLTKKYGGAEIYLKREDLNHTGAHKLNHCMGEALLAKYMGKKKLIAETGAGQHGVALATAAAYFGLECEIHMGEVDVKKEYPNVIRMKILGAKVVCVEFGDKTLKEAVDSAFEAYIKDIDNTFYAIGSVVGPHPFPKMVRDFQSIVGIESREQFLEMNGDGILPDIVTACVGGGSNAMGIFSGFISDKQVELICVEPLGKGNKIGEHAASITYGSEGIMHGFNSIMLKDEEGNPSKVHSIASGLDYPSVGPEIAYLNSIGRTKTVCITDQEAINGFFELSRTEGIIPAIESSHAIGYVLKIAKEMKGKKILINLSGRGDKDLDFVVQNYGYGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPE0</accession>
    <name>Q5CPE0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Variable surface protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_4530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000018">
        <property type="protein sequence ID" value="EAK87289.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625301.1">
        <property type="nucleotide sequence ID" value="XM_625301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPE0"/>
    <dbReference type="GeneID" id="3372302"/>
    <dbReference type="KEGG" id="cpv:cgd5_4530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4530"/>
    <dbReference type="InParanoid" id="Q5CPE0"/>
    <dbReference type="OrthoDB" id="10401262at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254336" description="Variable surface protein" evidence="2">
        <location>
            <begin position="22"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="138"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87289.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="272" mass="32122" checksum="A0BC2BD86845EEDB" modified="2005-04-12" version="1">MKLELLFIFSIIILINNKSNSSRNGLMNFSLLYIVNNSTSNDAEYYKKYNISANIPRKFMSIHPLEMYPQIRKNEHLYKHSKTSLAADCYKLIPEYSIILGLMEEYKSYLNFLMRVACGDDDGYHDGTGCGDANYLANTLLKDRIKLLRNERNKKLRECFKLELELISLNYIYFQEGDYVWKNGKKIADYDMTEIERSFIRKIITEYEKLLSIRLISYELYCVSKSNSKELIDCKRLESEGNTLSKVLKYISSEYLEKRLDLNKFENLFFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPF4</accession>
    <name>Q5CPF4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">mRNA translation inhibitor SKI2 SFII helicase, DEXDc+HELICc</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_280</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625339.1">
        <property type="nucleotide sequence ID" value="XM_625339.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CPF4">
        <property type="interactions" value="347"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPF4"/>
    <dbReference type="GeneID" id="3372331"/>
    <dbReference type="KEGG" id="cpv:cgd3_280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_280"/>
    <dbReference type="InParanoid" id="Q5CPF4"/>
    <dbReference type="OMA" id="DHVNIIM"/>
    <dbReference type="OrthoDB" id="64767at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055087">
        <property type="term" value="C:Ski complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070478">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000190">
        <property type="entry name" value="ATP-dependent RNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050699">
        <property type="entry name" value="RNA-DNA_Helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012961">
        <property type="entry name" value="Ski2/MTR4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131">
        <property type="entry name" value="ATP-DEPENDENT RNA AND DNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12131:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE SUPV3L1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08148">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01142">
        <property type="entry name" value="DSHCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="136"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="511"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="371"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="9"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="39"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="386"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="423"/>
            <end position="439"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1439" mass="165786" checksum="622AA78412EB5495" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPF7</accession>
    <name>Q5CPF7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CLU central domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87309.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625336.1">
        <property type="nucleotide sequence ID" value="XM_625336.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPF7"/>
    <dbReference type="GeneID" id="3372334"/>
    <dbReference type="KEGG" id="cpv:cgd3_230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_230"/>
    <dbReference type="InParanoid" id="Q5CPF7"/>
    <dbReference type="OMA" id="ETANCCH"/>
    <dbReference type="OrthoDB" id="626167at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033646">
        <property type="entry name" value="CLU-central"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12807">
        <property type="entry name" value="eIF3_p135"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CLU central" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2158"/>
            <end position="2179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87309.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2757" mass="317718" checksum="178F9D68BD9C946B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPI8</accession>
    <name>Q5CPI8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Spp2/MOS2 G-patch domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_220</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625361.1">
        <property type="nucleotide sequence ID" value="XM_625361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPI8"/>
    <dbReference type="GeneID" id="3375642"/>
    <dbReference type="KEGG" id="cpv:cgd6_220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_220"/>
    <dbReference type="InParanoid" id="Q5CPI8"/>
    <dbReference type="OrthoDB" id="5577072at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026822">
        <property type="entry name" value="Spp2/MOS2_G-patch"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12656">
        <property type="entry name" value="G-patch_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Spp2/MOS2 G-patch" evidence="4">
        <location>
            <begin position="119"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="103"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="158"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="16"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="177" mass="19620" checksum="198C1E5789FBD89E" modified="2005-04-12" version="1">MNNSKFSFSIKKPSEKNNSVAKSNSSIMGFEENDSSTGTSAGVDNKGAYKKDSIPCKRTLITSFSNTQSEIEQQSGDEHDELIIECKNPLKSSKNVNNIEILLNKKNSSNDTNEDDLDSSTNKDNFRIPVDKFGIAMLRGMGYNPEIHNTKPKIFKKRNYNQSGLGADKEIGSISKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPR2</accession>
    <name>Q5CPR2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_4370</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Endomembrane system</location>
            <topology evidence="5">Peripheral membrane protein</topology>
            <orientation evidence="5">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the adaptor complexes medium subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625452.1">
        <property type="nucleotide sequence ID" value="XM_625452.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPR2"/>
    <dbReference type="GeneID" id="3372445"/>
    <dbReference type="KEGG" id="cpv:cgd4_4370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4370"/>
    <dbReference type="InParanoid" id="Q5CPR2"/>
    <dbReference type="OMA" id="RITRTEI"/>
    <dbReference type="OrthoDB" id="1877176at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030119">
        <property type="term" value="C:AP-type membrane coat adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005764">
        <property type="term" value="C:lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039591">
        <property type="entry name" value="AP5M1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16082">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT MU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16082:SF2">
        <property type="entry name" value="AP-5 COMPLEX SUBUNIT MU-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005324"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00029433"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="835" mass="95666" checksum="ECE3C5D6AF893C9E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPS2</accession>
    <name>Q5CPS2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_4270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625442.1">
        <property type="nucleotide sequence ID" value="XM_625442.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPS2"/>
    <dbReference type="GeneID" id="3372394"/>
    <dbReference type="KEGG" id="cpv:cgd4_4270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4270"/>
    <dbReference type="InParanoid" id="Q5CPS2"/>
    <dbReference type="OrthoDB" id="343079at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253723" evidence="2">
        <location>
            <begin position="24"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="103"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="315" mass="37007" checksum="449C4A32FDAA23EF" modified="2005-04-12" version="1">MKLIHVFSPIFLLFVIFCDFTERSFLSKISLVRTKIIHKESNAKDGIIIPDLSDTPKNEEPLYLVEGLIDLSEEVDDDDDYRDEIIFIDDMERSNLDEPTSNDDDKLSSGDETRNINDSQNNDELEIDNKSEIPEFNTELYFNSHKCFLMLGFEVEFLENPILNNSGVLKYIKEAEINTEGETVKNHEYTDDEKYKLIELETRNKKRDEIISLMKHLRESCWNITSQSTLEEFKNEVLDIIEIVKSKICQINIKLENYIKITDKENSEFDFDNYESNMEKKSKLFGRKSSYKLALSSLKRIEEYWSHIENLPCNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPS5</accession>
    <name>Q5CPS5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Insulinase like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_4240</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625439.1">
        <property type="nucleotide sequence ID" value="XM_625439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPS5"/>
    <dbReference type="GeneID" id="3372397"/>
    <dbReference type="KEGG" id="cpv:cgd4_4240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4240"/>
    <dbReference type="InParanoid" id="Q5CPS5"/>
    <dbReference type="OrthoDB" id="340032at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="2">
        <location>
            <begin position="182"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1150" mass="133650" checksum="E8AB3CDD4FC47ACC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPT7</accession>
    <name>Q5CPT7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Rab GDP dissociation inhibitor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_4080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the Rab GDI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625427.1">
        <property type="nucleotide sequence ID" value="XM_625427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPT7"/>
    <dbReference type="FunCoup" id="Q5CPT7">
        <property type="interactions" value="326"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPT7"/>
    <dbReference type="GeneID" id="3372406"/>
    <dbReference type="KEGG" id="cpv:cgd4_4080"/>
    <dbReference type="InParanoid" id="Q5CPT7"/>
    <dbReference type="OMA" id="FETKAKM"/>
    <dbReference type="OrthoDB" id="9446342at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005093">
        <property type="term" value="F:Rab GDP-dissociation inhibitor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007264">
        <property type="term" value="P:small GTPase-mediated signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.405.10:FF:000001">
        <property type="entry name" value="Rab GDP dissociation inhibitor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.405.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.519.10">
        <property type="entry name" value="Guanine Nucleotide Dissociation Inhibitor, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018203">
        <property type="entry name" value="GDP_dissociation_inhibitor"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000806">
        <property type="entry name" value="RabGDI"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787:SF8">
        <property type="entry name" value="RAB GDP DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11787">
        <property type="entry name" value="RAB GDP-DISSOCIATION INHIBITOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00996">
        <property type="entry name" value="GDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00892">
        <property type="entry name" value="RABGDI"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00891">
        <property type="entry name" value="RABGDIREP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU363124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="473" mass="53148" checksum="A2E550047B73B6A1" modified="2005-04-12" version="1" fragment="single">YYLEQLIKRLNIIMDEKYDVLICGTGLTECIISGLLSTSGKKVLHIDRNSYYGGEAASLNLTTLYQKFRPGTSPPANYGANRDWNVDLIPKFVMASGDLVKILLKTKVTRYLEWQVIEGTYVYQFQKGGLLFNPKFIHKVPATEMEALKSPLLGIMEKNRCRSFFSFVANWSDDDVSKQMGFNRDKNTMKDIYDHFGLSSTTIDFVGHALALYTNDDYINKPCGETLDKIRLYMMSLSRYGKSPFIYPVYGLGGLPEGFSRLCAIHGGTFMLNTNIEKFLYDEQGKVSGVVTSQGKAECKMVICDPSYVLNENDSKPKVKCIGKVLRCICILNSPINDTNDVSSCQIIIPQNELGRKNDIYVMMVSCTHGVALKGKYIAIISTTVETENPLLEINPAIKLLGNSIEEQFFYTSDLYEPIDSGKDDNVFVSKSCDASSHFESLTQDVLRLWKNITGEDLDLTNIPNEDEADGEY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPY1</accession>
    <name>Q5CPY1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative vacuolar ATP synthase subunit E</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase E subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87507.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625498.1">
        <property type="nucleotide sequence ID" value="XM_625498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPY1"/>
    <dbReference type="FunCoup" id="Q5CPY1">
        <property type="interactions" value="259"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPY1"/>
    <dbReference type="GeneID" id="3372469"/>
    <dbReference type="KEGG" id="cpv:cgd8_360"/>
    <dbReference type="InParanoid" id="Q5CPY1"/>
    <dbReference type="OMA" id="QHMMAFI"/>
    <dbReference type="OrthoDB" id="10263003at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033178">
        <property type="term" value="C:proton-transporting two-sector ATPase complex, catalytic domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2320.30">
        <property type="entry name" value="ATP synthase, E subunit, C-terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00311">
        <property type="entry name" value="ATP_synth_E_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038495">
        <property type="entry name" value="ATPase_E_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002842">
        <property type="entry name" value="ATPase_V1_Esu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45715">
        <property type="entry name" value="ATPASE H+-TRANSPORTING V1 SUBUNIT E1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01991">
        <property type="entry name" value="vATP-synt_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160527">
        <property type="entry name" value="V-type ATPase subunit E-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005901"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87507.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="252" mass="28470" checksum="2C3F3F14452E6F14" modified="2005-04-12" version="1" fragment="single">VFNVNVTIYINFSFLSLIQDDIEAQKQIQQMINFILNEAKDKANEIEAKALQDFNIEKLKLVQSYKEQIRQDLKKKVKRLEVERAIARSTAINKARLKKMAARAQVLTEVVQQTRKKMCEISTNPTVYEPLLVDLLTQAMLKLLEPTVIVKCRKSDVSVVESAIPKAIKKYKEILQKECGVSMNVEAKVDKENFLFPAPTSVEQNSKYCSGGVIVTNLDGKIVCNNTLDARLDLVIQNDAPIIRSTLFPKAA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ39</accession>
    <name>Q5CQ39_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_4250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625587.1">
        <property type="nucleotide sequence ID" value="XM_625587.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ39"/>
    <dbReference type="STRING" id="353152.Q5CQ39"/>
    <dbReference type="GeneID" id="3372571"/>
    <dbReference type="KEGG" id="cpv:cgd5_4250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4250"/>
    <dbReference type="InParanoid" id="Q5CQ39"/>
    <dbReference type="OrthoDB" id="343004at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="377"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="766"/>
            <end position="792"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="21"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="268"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="380"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="766"/>
            <end position="788"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="865" mass="93935" checksum="75F91D5698C15027" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQG0</accession>
    <name>Q5CQG0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative WWE domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625688.1">
        <property type="nucleotide sequence ID" value="XM_625688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQG0"/>
    <dbReference type="GeneID" id="3372696"/>
    <dbReference type="KEGG" id="cpv:cgd4_860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_860"/>
    <dbReference type="InParanoid" id="Q5CQG0"/>
    <dbReference type="OrthoDB" id="344122at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.720.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018123">
        <property type="entry name" value="WWE-dom_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004170">
        <property type="entry name" value="WWE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037197">
        <property type="entry name" value="WWE_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02825">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00678">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117839">
        <property type="entry name" value="WWE domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50918">
        <property type="entry name" value="WWE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WWE" evidence="2">
        <location>
            <begin position="97"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="389"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="407"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="503"/>
            <end position="515"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="534"/>
            <end position="546"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50918"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1246" mass="140552" checksum="619123A79197CB7C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQP2</accession>
    <name>Q5CQP2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">T-complex protein 1 subunit gamma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd4_3850</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625960.1">
        <property type="nucleotide sequence ID" value="XM_625960.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQP2"/>
    <dbReference type="FunCoup" id="Q5CQP2">
        <property type="interactions" value="520"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQP2"/>
    <dbReference type="GeneID" id="3372934"/>
    <dbReference type="KEGG" id="cpv:cgd4_3850"/>
    <dbReference type="InParanoid" id="Q5CQP2"/>
    <dbReference type="OMA" id="CGGSTIR"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005832">
        <property type="term" value="C:chaperonin-containing T-complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03337">
        <property type="entry name" value="TCP1_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.560.10:FF:000085">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000005">
        <property type="entry name" value="T-complex protein 1 subunit gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012719">
        <property type="entry name" value="Chap_CCT_gamma"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02344">
        <property type="entry name" value="chap_CCT_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="537"/>
            <end position="559"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="540"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00017187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="559" mass="61122" checksum="E9AED2C3DBECDE38" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQP8</accession>
    <name>Q5CQP8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3790</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87751.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625954.1">
        <property type="nucleotide sequence ID" value="XM_625954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQP8"/>
    <dbReference type="GeneID" id="3372798"/>
    <dbReference type="KEGG" id="cpv:cgd4_3790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3790"/>
    <dbReference type="InParanoid" id="Q5CQP8"/>
    <dbReference type="OMA" id="LTEPTIC"/>
    <dbReference type="OrthoDB" id="337840at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="313"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87751.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="333" mass="38661" checksum="D4685E33392A4625" modified="2005-04-12" version="1">MLDINYKNVLSIGDQLFPELELRPFLINLPLNKNENTRDGIKKKIYRSFSYKIEEYRKELNIFMNEDNVFNLIFDNIESLDENILRGFSQIIDLNDKDSNTVEDVIGLLNDPNICGFIFIIAKPIHIEEPGKTLNFKPILGAVIELVDDNERAIRMMFCKRRFPYSISEMLIRLSIGRVFIHALKWNYDDGSKKRKSSNKLVSILDEHIQFFPIPAYNILIKEMNMSPHWELSTKKIAHSDSFKAKCPCYKFSKLEESRKFWGISESRYISTIKSNPQIFGSLINLSDFSNCDLFKHVQNNLKHNEIISNESSSSISNIDSPSSSISKKRRVT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQQ3</accession>
    <name>Q5CQQ3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BCNT-C domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3730</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87755.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625949.1">
        <property type="nucleotide sequence ID" value="XM_625949.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQQ3"/>
    <dbReference type="STRING" id="353152.Q5CQQ3"/>
    <dbReference type="GeneID" id="3372802"/>
    <dbReference type="KEGG" id="cpv:cgd4_3730"/>
    <dbReference type="InParanoid" id="Q5CQQ3"/>
    <dbReference type="OMA" id="KHTPNGN"/>
    <dbReference type="OrthoDB" id="445677at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011421">
        <property type="entry name" value="BCNT-C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027124">
        <property type="entry name" value="Swc5/CFDP1/2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48295">
        <property type="entry name" value="CRANIOFACIAL DEVELOPMENT PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48295:SF1">
        <property type="entry name" value="SWR1-COMPLEX PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07572">
        <property type="entry name" value="BCNT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51279">
        <property type="entry name" value="BCNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BCNT-C" evidence="1">
        <location>
            <begin position="48"/>
            <end position="126"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87755.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="138" mass="15709" checksum="43A4C8D43AF132B3" modified="2005-04-12" version="1">MIEEALGSLEEKGVRYIDKKVKYAGETYTIKEKVDPETFSRKKARTSSTGMQALDEIVANLNKEININSIQKSHSDWTEFRQMAGLESQLERQRKHGYISKTAFLQKADWKLHEKELEIKRRSGGNNNISSSSNASGN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQT6</accession>
    <name>Q5CQT6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Neutral sphingomyelinase activation associated factor-like BEACH domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_3390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625916.1">
        <property type="nucleotide sequence ID" value="XM_625916.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQT6"/>
    <dbReference type="GeneID" id="3372871"/>
    <dbReference type="KEGG" id="cpv:cgd4_3390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3390"/>
    <dbReference type="InParanoid" id="Q5CQT6"/>
    <dbReference type="OrthoDB" id="26681at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd06071">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1540.10">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000409">
        <property type="entry name" value="BEACH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036372">
        <property type="entry name" value="BEACH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050865">
        <property type="entry name" value="BEACH_Domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057496">
        <property type="entry name" value="FAN-like_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023362">
        <property type="entry name" value="PH-BEACH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743">
        <property type="entry name" value="BEIGE/BEACH-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13743:SF123">
        <property type="entry name" value="PROTEIN FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02138">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25400">
        <property type="entry name" value="PH_FAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01026">
        <property type="entry name" value="Beach"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81837">
        <property type="entry name" value="BEACH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50197">
        <property type="entry name" value="BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51783">
        <property type="entry name" value="PH_BEACH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BEACH-type PH" evidence="3">
        <location>
            <begin position="190"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="domain" description="BEACH" evidence="2">
        <location>
            <begin position="342"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1031"/>
            <end position="1052"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1034"/>
            <end position="1052"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50197"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51783"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1326" mass="152633" checksum="87CEEF697D7A087B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQU8</accession>
    <name>Q5CQU8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_3230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87797.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625904.1">
        <property type="nucleotide sequence ID" value="XM_625904.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQU8"/>
    <dbReference type="GeneID" id="3372785"/>
    <dbReference type="KEGG" id="cpv:cgd4_3230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3230"/>
    <dbReference type="InParanoid" id="Q5CQU8"/>
    <dbReference type="OMA" id="NSEWISC"/>
    <dbReference type="OrthoDB" id="336547at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253755" evidence="2">
        <location>
            <begin position="19"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="376"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="424"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87797.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="692" mass="80664" checksum="9A23833804D3859F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR18</accession>
    <name>Q5CR18_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625834.1">
        <property type="nucleotide sequence ID" value="XM_625834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR18"/>
    <dbReference type="GeneID" id="3372879"/>
    <dbReference type="KEGG" id="cpv:cgd4_2460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2460"/>
    <dbReference type="InParanoid" id="Q5CR18"/>
    <dbReference type="OMA" id="IAQCINI"/>
    <dbReference type="OrthoDB" id="336916at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253762" evidence="1">
        <location>
            <begin position="20"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="299" mass="33797" checksum="2742E08DF7F126D2" modified="2005-04-12" version="1">MKLWFLVFAFVINSAFIESSRVLSSYGCYSLLGKLPRMSALSRSITPINVHEYNQEDVSIVCISLVKGAEFKFDQHDSIIDLSNNAHGISLVLPKSEILSGLYGSSLEPIIISSCKKAKILLSSQPNTKLMLLQPFIIFSCIEVVKQQTPIPQTKPEKSKSHPPQIDYLSLGSGIPFGKRPYECRFDSPTFAKEGSSINYKKKQVYWTCFSKVEELLVMNFFSENNISEKVLLSIVDDMRSTSNKISVKSPCNGTMHDNKQGILNKNQVFLRIECEEENLPKLLINKDFGLRQTQLRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR55</accession>
    <name>Q5CR55_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Centromeric histone h3-like protein, cse4 like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd4_2030</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87944.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625797.1">
        <property type="nucleotide sequence ID" value="XM_625797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR55"/>
    <dbReference type="STRING" id="353152.Q5CR55"/>
    <dbReference type="GeneID" id="3372760"/>
    <dbReference type="KEGG" id="cpv:cgd4_2030"/>
    <dbReference type="InParanoid" id="Q5CR55"/>
    <dbReference type="OMA" id="LKFVPHG"/>
    <dbReference type="OrthoDB" id="4025405at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000085">
        <property type="entry name" value="Histone H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810:SF1">
        <property type="entry name" value="HISTONE H3-LIKE CENTROMERIC PROTEIN A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45810">
        <property type="entry name" value="HISTONE H3.2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="8">
        <location>
            <begin position="1"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87944.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="98" mass="11311" checksum="BF2D5B80CB0CB855" modified="2005-04-12" version="1" fragment="single">GTVALREIRKYQASTDLLIAKLPFARVVREVTLKFVPHGEMWRWNAEALHAIQCAAEAFLQGLFEDAYLCTLHSKRVTLLPRDIRLARQLRGRYGDFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRA1</accession>
    <name>Q5CRA1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd4_1550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="8">Endomembrane system</location>
            <topology evidence="8">Single-pass type IV membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87953.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625751.1">
        <property type="nucleotide sequence ID" value="XM_625751.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRA1"/>
    <dbReference type="FunCoup" id="Q5CRA1">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRA1"/>
    <dbReference type="GeneID" id="3372769"/>
    <dbReference type="KEGG" id="cpv:cgd4_1550"/>
    <dbReference type="InParanoid" id="Q5CRA1"/>
    <dbReference type="OMA" id="HIWIMSF"/>
    <dbReference type="OrthoDB" id="261831at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15853">
        <property type="entry name" value="SNARE_Bet1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039899">
        <property type="entry name" value="BET1_SNARE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12791">
        <property type="entry name" value="GOLGI SNARE BET1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="72"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="10">
        <location>
            <begin position="1"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87953.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="93" mass="10831" checksum="0B866CE9FFD9DF3E" modified="2005-04-12" version="1" fragment="single">SILEEQNDQYMIDLEAKVQDLKYISNTMRQQVKESNDLLSSLSEEMGSFGVLLKGTINKIKTIGGTSSWKHIWIMSFFIFLVFLLMYILFKRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRC6</accession>
    <name>Q5CRC6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative vacuolar ATP synthase subunit d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_3340</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase V0D/AC39 subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88229.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626260.1">
        <property type="nucleotide sequence ID" value="XM_626260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRC6"/>
    <dbReference type="FunCoup" id="Q5CRC6">
        <property type="interactions" value="253"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRC6"/>
    <dbReference type="GeneID" id="3373217"/>
    <dbReference type="KEGG" id="cpv:cgd5_3340"/>
    <dbReference type="InParanoid" id="Q5CRC6"/>
    <dbReference type="OMA" id="MTYGYMI"/>
    <dbReference type="OrthoDB" id="10250083at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033179">
        <property type="term" value="C:proton-transporting V-type ATPase, V0 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.50">
        <property type="entry name" value="ATP synthase (C/AC39) subunit, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1690.10">
        <property type="entry name" value="V-type ATP synthase subunit C domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036079">
        <property type="entry name" value="ATPase_csu/dsu_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002843">
        <property type="entry name" value="ATPase_V0-cplx_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016727">
        <property type="entry name" value="ATPase_V0-cplx_dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035067">
        <property type="entry name" value="V-type_ATPase_csu/dsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044911">
        <property type="entry name" value="V-type_ATPase_csu/dsu_dom_3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11028">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01992">
        <property type="entry name" value="vATP-synt_AC39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103486">
        <property type="entry name" value="V-type ATP synthase subunit C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88229.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="412" mass="47746" checksum="3593A1BB9C31C908" modified="2005-04-12" version="1" fragment="single">EEKRREKGVLLLSTKFKMELLTFNLKDGYLEAMVRGYRSGFITMDEYHLIGQAETLEDMRTALEETDYGTFMQDEPLPLSVNVITQKCREKFAHEFRMLQSQAYEPLGKFLNYITYEKMIDNVVNLIQGALNKKPAEELLARLDPLGYFPEIRAFVALDLSSSFDELYKSILIETPIGPYFDEFLTSFSGENEDVTSIVKEMDLEILRSSLKKSWLEDFYRFCQTLNPTSAEVMSHVLKCEADFRLLAITLNSLNFNFSSASTLYPSFGYLYPEGTEQIRKAWNDTRVRAALEPYSKYSALYDQCKAFYVNDTANDFGLADDKDESTDKKKSSSHKNLADRQFKSLEDLLYAETVSMCELVFDQQMNYGVFYAWARLKEQEIRNLTWIAEMILMNRKDQVDAIVPIFAPRAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRF1</accession>
    <name>Q5CRF1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88010.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626235.1">
        <property type="nucleotide sequence ID" value="XM_626235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRF1"/>
    <dbReference type="GeneID" id="3373248"/>
    <dbReference type="KEGG" id="cpv:cgd5_3030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3030"/>
    <dbReference type="InParanoid" id="Q5CRF1"/>
    <dbReference type="OrthoDB" id="343546at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="101"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88010.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="112" mass="12558" checksum="7116E5BFA569AE5A" modified="2005-04-12" version="1">MSNTVKTVTTINEQVIEVVSNLETNKISEKLEDISTKVNQLLTGYISKENDESSVSSQDEYEGQTSEETSLNKCLNAKYKSANYESEKESNPVDNSETTSRGKRHKKDTSDK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRL0</accession>
    <name>Q5CRL0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">tRNA(m1A58)-methyltransferase subunit TRM6</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_2390</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TRM6/GCD10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626176.1">
        <property type="nucleotide sequence ID" value="XM_626176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRL0"/>
    <dbReference type="STRING" id="353152.Q5CRL0"/>
    <dbReference type="GeneID" id="3373146"/>
    <dbReference type="KEGG" id="cpv:cgd5_2390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2390"/>
    <dbReference type="InParanoid" id="Q5CRL0"/>
    <dbReference type="OMA" id="RRTHPVM"/>
    <dbReference type="OrthoDB" id="10254665at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017423">
        <property type="entry name" value="TRM6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12945:SF0">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE NON-CATALYTIC SUBUNIT TRM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04189">
        <property type="entry name" value="Gcd10p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="115"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="415"/>
            <end position="443"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="123"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008320"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00021704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="548" mass="62941" checksum="9DEFE831B96DB161" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRQ9</accession>
    <name>Q5CRQ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Vir superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_1840</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ESF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626127.1">
        <property type="nucleotide sequence ID" value="XM_626127.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRQ9"/>
    <dbReference type="STRING" id="353152.Q5CRQ9"/>
    <dbReference type="GeneID" id="3373276"/>
    <dbReference type="KEGG" id="cpv:cgd5_1840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1840"/>
    <dbReference type="InParanoid" id="Q5CRQ9"/>
    <dbReference type="OMA" id="YEMEMSW"/>
    <dbReference type="OrthoDB" id="431825at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039754">
        <property type="entry name" value="Esf1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012580">
        <property type="entry name" value="NUC153"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056750">
        <property type="entry name" value="RRM_ESF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12202:SF0">
        <property type="entry name" value="ESF1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08159">
        <property type="entry name" value="NUC153"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25121">
        <property type="entry name" value="RRM_ESF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ESF1 RRM" evidence="7">
        <location>
            <begin position="153"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="domain" description="NUC153" evidence="6">
        <location>
            <begin position="585"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="520"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="10"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="523"/>
            <end position="534"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF25121"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="664" mass="76639" checksum="F121A0909AAD149F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS11</accession>
    <name>Q5CS11_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Musashi. RRM domain containing protein, splicing related</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626025.1">
        <property type="nucleotide sequence ID" value="XM_626025.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS11"/>
    <dbReference type="STRING" id="353152.Q5CS11"/>
    <dbReference type="GeneID" id="3373306"/>
    <dbReference type="KEGG" id="cpv:cgd5_700"/>
    <dbReference type="InParanoid" id="Q5CS11"/>
    <dbReference type="OMA" id="PPIHHAT"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12325">
        <property type="entry name" value="RRM1_hnRNPA_hnRNPD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF18">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="23"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="166"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="105"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="249"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="344"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="388"/>
            <end position="473"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="113"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="350"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="389"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="424"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="439"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="6">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="507" mass="53218" checksum="8B8B4BFB9826297E" modified="2005-04-12" version="1" fragment="single">LITNTMTTLQTEGGSSGGPTVPAKIFCGGLSDVTTNASLRTHFSPYGEIVDSVVLTEKTTGRSRGFGFITFASEESVDAVLSSPQIVDGKEIDCKRAVPRGVIQANEADESADSNNQASNNSGNTNANNANISGNSGSNTANSNSNVTGRSHIGGAGGSSGGFSATKIFVGGLPQSCTDEKLREHFGKYGTIKNLSVMVDRDTNRHRGFGFVEYESPDAVEEVMRHYYDHQIDNKWVECKKALPREIMAGNSNQSNSGGHAPSLGNPRVRTNPALAAASTTANSNYADYYRNPYLPVHAGGVPSQQIYGRYGRHDPRYMYTGYASGYSSNIYATGGYGQIAPPIHHATAPGPQSSASVSVSMPPVIPNLGSHYGDVSPEQTGNLQVQTAGSAGASNASNLNASNVSNNNSSSAPNYDNQEDYLSEQQGVSDSNVHPYHHPATSTASTSSAAAPGAHPPRPAIPPPHMYAPNMARPGPYAQGRYAPSGALPYSVPGAVPTHGRLRGMY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="120" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS33</accession>
    <name>Q5CS33_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA repair protein RAD51 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd5_410</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the RecA family. RAD51 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88173.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626003.1">
        <property type="nucleotide sequence ID" value="XM_626003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS33"/>
    <dbReference type="FunCoup" id="Q5CS33">
        <property type="interactions" value="251"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS33"/>
    <dbReference type="GeneID" id="3373180"/>
    <dbReference type="KEGG" id="cpv:cgd5_410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_410"/>
    <dbReference type="InParanoid" id="Q5CS33"/>
    <dbReference type="OMA" id="RAYNSNH"/>
    <dbReference type="OrthoDB" id="10251254at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000794">
        <property type="term" value="C:condensed nuclear chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000150">
        <property type="term" value="F:DNA strand exchange activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003690">
        <property type="term" value="F:double-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070192">
        <property type="term" value="P:chromosome organization involved in meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000730">
        <property type="term" value="P:DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042148">
        <property type="term" value="P:DNA strand invasion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006312">
        <property type="term" value="P:mitotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990426">
        <property type="term" value="P:mitotic recombination-dependent replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd19513">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000092">
        <property type="entry name" value="DNA repair protein Rad51 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011941">
        <property type="entry name" value="DNA_recomb/repair_Rad51"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016467">
        <property type="entry name" value="DNA_recomb/repair_RecA-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010995">
        <property type="entry name" value="DNA_repair_Rad51/TF_NusA_a-hlx"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013632">
        <property type="entry name" value="Rad51_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020587">
        <property type="entry name" value="RecA_monomer-monomer_interface"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003301">
        <property type="entry name" value="PRK04301.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02239">
        <property type="entry name" value="recomb_RAD51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942:SF39">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22942">
        <property type="entry name" value="RECA/RAD51/RADA DNA STRAND-PAIRING FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08423">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005856">
        <property type="entry name" value="Rad51"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47794">
        <property type="entry name" value="Rad51 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50163">
        <property type="entry name" value="RECA_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="7" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="7" id="KW-0234">DNA repair</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="8">
        <location>
            <begin position="104"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="RecA family profile 2" evidence="9">
        <location>
            <begin position="283"/>
            <end position="345"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007095"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003422"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU364139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88173.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="347" mass="38349" checksum="B299E8D711C96FA1" modified="2005-04-12" version="1">MSTINPNEIVNENNENQNNLNETVYNGPLKLEHLLPSGLTKRDLEILRENGYHTIECLAYAPKKALLSVKGISEQKCDKIKSACKELVAMGFCSGTEYLEARTNLIKFTTGSSQLDRLLQGGIETGSITEIFGEFRTGKTQLCHTLAVTCQLPVEHKGGEGKCLWIDTEGTFRPERIVQIADRFNLNASDCLDNIAYARGFNTEHQMDLLQSAVAMMTESRFALMIVDSATALYRSEYNGRGELATRQSHLGQFLRALQKIADTFGVAVVITNQVMSKVDAMAAMFQNDKVPIGGNIIAHASQTRLFLKKGRGETRICKIYDSPNLPEGDATFSITEGGINDPKDEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS45</accession>
    <name>Q5CS45_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88184.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625991.1">
        <property type="nucleotide sequence ID" value="XM_625991.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS45"/>
    <dbReference type="GeneID" id="3373191"/>
    <dbReference type="KEGG" id="cpv:cgd5_290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_290"/>
    <dbReference type="InParanoid" id="Q5CS45"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="120"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88184.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="253" mass="28992" checksum="51F9880067186711" modified="2005-04-12" version="1">MLKKQKFQNGGLFLLLLLLTFGSLISLISNTSKIYSIIIEDLKKNIFKEETILSYIYSISIIGFCIIPSGILFSKPNASRNVLLYGILITLFGYISLYVTQKICIYYMMVNVLNDLSNSIIFTFLYGISFALILQGGVTLNLGSLWINLLYWPIKYSGLITSIQFTIYSIGGLSLSEIYRLCFLESGSIRHFFLTCFFISLLIGFSSIYMIINIEKKILLNNQQVFENLCEDSNNHNKEINDEDRESLTMRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS47</accession>
    <name>Q5CS47_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Unc45-like TPR repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625989.1">
        <property type="nucleotide sequence ID" value="XM_625989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS47"/>
    <dbReference type="STRING" id="353152.Q5CS47"/>
    <dbReference type="GeneID" id="3373315"/>
    <dbReference type="KEGG" id="cpv:cgd5_270"/>
    <dbReference type="InParanoid" id="Q5CS47"/>
    <dbReference type="OMA" id="RSREYKQ"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45994:SF1">
        <property type="entry name" value="FI21225P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="379" mass="43290" checksum="10773C75804C128F" modified="2005-04-12" version="1" fragment="single">TFTRYTRNERNGHYDRGDEILANTYRKLMIEKSNIISFMYIILEKNISNNNINDNNNKNTTSSSLPFIFNIANNIVDLIVNTEDLNEKNSKEILSLRGKIIQKGGLKCLLDSITIIDNELLNLKSNKSSSTNIFSINKKYLIDRSREYKQAISKLLIYISPTLISYKLLVECAIKIQSLLEDEHELLQYESALAITNILSKSFDKISQDSENDSISIRIYNSGLGWSLLKSLCFTDNNLLRAAGLEGLCNFCNKDYVVLNHFISSKSNGIEDLKLFIAFSQEQDNRIQIAALGALAMLSSYSDVSKIIIDNWNQFGIQLIQVSEDFYNNNNNNLEVKERLVFCLNNLLLYISSQNNNNNNNQVLLNIHKSIQDCIIFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS57</accession>
    <name>Q5CS57_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">HARP like SWI/SNF ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_150</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625979.1">
        <property type="nucleotide sequence ID" value="XM_625979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS57"/>
    <dbReference type="FunCoup" id="Q5CS57">
        <property type="interactions" value="7"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS57"/>
    <dbReference type="GeneID" id="3373201"/>
    <dbReference type="KEGG" id="cpv:cgd5_150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_150"/>
    <dbReference type="InParanoid" id="Q5CS57"/>
    <dbReference type="OMA" id="NINYNEC"/>
    <dbReference type="OrthoDB" id="2801544at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043596">
        <property type="term" value="C:nuclear replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031297">
        <property type="term" value="P:replication fork processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766:SF3">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45766">
        <property type="entry name" value="DNA ANNEALING HELICASE AND ENDONUCLEASE ZRANB3 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="380"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="735"/>
            <end position="901"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="548"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="548"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="576"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="908" mass="104066" checksum="737D63F9775C6A16" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSB2</accession>
    <name>Q5CSB2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">DNA replication complex GINS protein PSF2, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628155.1">
        <property type="nucleotide sequence ID" value="XM_628155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSB2"/>
    <dbReference type="STRING" id="353152.Q5CSB2"/>
    <dbReference type="GeneID" id="3371449"/>
    <dbReference type="KEGG" id="cpv:cgd1_3410"/>
    <dbReference type="InParanoid" id="Q5CSB2"/>
    <dbReference type="OMA" id="IANIYFQ"/>
    <dbReference type="OrthoDB" id="1938138at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.5.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007257">
        <property type="entry name" value="GINS_Psf2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056784">
        <property type="entry name" value="PSF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12772:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN PSF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25005">
        <property type="entry name" value="PSF2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160059">
        <property type="entry name" value="PriA/YqbF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA replication complex GINS protein PSF2 N-terminal" evidence="1">
        <location>
            <begin position="2"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="90" mass="10663" checksum="CE6950571CA85D71" modified="2005-04-12" version="1" fragment="single">VEIGPFIPYQKSKVPLWIAKYLDSKNLCKLIPPNWLTQEGLRKLLVDEDKLGQETFCFIDFYYYQIANIYFQLRNDPFNGKKSKVKSKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSF3</accession>
    <name>Q5CSF3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">14-3-3 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_2980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2011" name="PLoS ONE" volume="6" first="e14827" last="e14827">
            <title>Characterization of 14-3-3 proteins from Cryptosporidium parvum.</title>
            <authorList>
                <person name="Brokx S.J."/>
                <person name="Wernimont A.K."/>
                <person name="Dong A."/>
                <person name="Wasney G.A."/>
                <person name="Lin Y.H."/>
                <person name="Lew J."/>
                <person name="Vedadi M."/>
                <person name="Lee W.H."/>
                <person name="Hui R."/>
            </authorList>
            <dbReference type="PubMed" id="21853016"/>
            <dbReference type="DOI" id="10.1371/journal.pone.0014827"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS)</scope>
        <scope>PHOSPHORYLATION AT SER-244</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the 14-3-3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88553.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628114.1">
        <property type="nucleotide sequence ID" value="XM_628114.1"/>
    </dbReference>
    <dbReference type="PDB" id="3EFZ">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.08 A"/>
        <property type="chains" value="A/B/C/D=1-247"/>
    </dbReference>
    <dbReference type="PDBsum" id="3EFZ"/>
    <dbReference type="AlphaFoldDB" id="Q5CSF3"/>
    <dbReference type="SMR" id="Q5CSF3"/>
    <dbReference type="STRING" id="353152.Q5CSF3"/>
    <dbReference type="GeneID" id="3371341"/>
    <dbReference type="KEGG" id="cpv:cgd1_2980"/>
    <dbReference type="InParanoid" id="Q5CSF3"/>
    <dbReference type="OMA" id="GARAFCI"/>
    <dbReference type="OrthoDB" id="340699at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CSF3"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd08774">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.190.20">
        <property type="entry name" value="14-3-3 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000308">
        <property type="entry name" value="14-3-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036815">
        <property type="entry name" value="14-3-3_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023410">
        <property type="entry name" value="14-3-3_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18860">
        <property type="entry name" value="14-3-3 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00244">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000868">
        <property type="entry name" value="14-3-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00305">
        <property type="entry name" value="1433ZETA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00101">
        <property type="entry name" value="14_3_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48445">
        <property type="entry name" value="14-3-3 protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="6" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="14-3-3" evidence="3">
        <location>
            <begin position="9"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="58"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with phosphoserine on interacting protein" evidence="2">
        <location>
            <position position="132"/>
        </location>
    </feature>
    <feature type="modified residue" description="Phosphoserine" evidence="6">
        <location>
            <position position="244"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000868-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88553.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="6">
        <source>
            <dbReference type="PDB" id="3EFZ"/>
        </source>
    </evidence>
    <sequence length="247" mass="28481" checksum="4DEE6204DD935F4F" modified="2005-04-12" version="1" fragment="single">ITEKNMKLSEGAYRAKLADMVGNYKDVIKVLTESSDFRDNSLILLLAGSLRNRVTSIRNSLKSIKSQEEKLRKEKSLNNEFIQVIEDIKRDFEESILLESEDVIRIIDDNLLMYSEEGARAFCIKLKGDLMRYKAEILKDEEKNQCIKQAVEFYEDALQRERSFLEKYPSDPLYLATILNYTILKYDLLGNPEGAMKFANRAIQAAENSRSDSEQFSENTEKLLKILRDNVSQWEQGCSGLLTSAFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSI4</accession>
    <name>Q5CSI4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Possible conserved eukaryotic alpha beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88362.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628083.1">
        <property type="nucleotide sequence ID" value="XM_628083.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSI4"/>
    <dbReference type="GeneID" id="3371691"/>
    <dbReference type="KEGG" id="cpv:cgd1_2570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2570"/>
    <dbReference type="InParanoid" id="Q5CSI4"/>
    <dbReference type="OMA" id="ANWSHIL"/>
    <dbReference type="OrthoDB" id="10249433at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008536">
        <property type="entry name" value="DUF818"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF197">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_38, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05677">
        <property type="entry name" value="DUF818"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="309"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88362.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1448" mass="168397" checksum="D7AB43A8CD82E1CD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSL5</accession>
    <name>Q5CSL5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">CDC48 like AAA ATPase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_2180</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628052.1">
        <property type="nucleotide sequence ID" value="XM_628052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSL5"/>
    <dbReference type="STRING" id="353152.Q5CSL5"/>
    <dbReference type="GeneID" id="3371678"/>
    <dbReference type="KEGG" id="cpv:cgd1_2180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2180"/>
    <dbReference type="InParanoid" id="Q5CSL5"/>
    <dbReference type="OrthoDB" id="5925at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19481">
        <property type="entry name" value="RecA-like_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="374"/>
            <end position="512"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="593" mass="68155" checksum="4AB0FE35D863D9D7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSZ8</accession>
    <name>Q5CSZ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted secreted protein, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627919.1">
        <property type="nucleotide sequence ID" value="XM_627919.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSZ8"/>
    <dbReference type="GeneID" id="3371538"/>
    <dbReference type="KEGG" id="cpv:cgd1_670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_670"/>
    <dbReference type="InParanoid" id="Q5CSZ8"/>
    <dbReference type="OMA" id="CENIRQF"/>
    <dbReference type="OrthoDB" id="339032at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254933" evidence="2">
        <location>
            <begin position="19"/>
            <end position="1176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="121"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1176" mass="135142" checksum="BC796543204B5A10" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTG8</accession>
    <name>Q5CTG8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High mobility group (HMG)-box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_3070</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626501.1">
        <property type="nucleotide sequence ID" value="XM_626501.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTG8"/>
    <dbReference type="STRING" id="353152.Q5CTG8"/>
    <dbReference type="GeneID" id="3373567"/>
    <dbReference type="KEGG" id="cpv:cgd2_3070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3070"/>
    <dbReference type="InParanoid" id="Q5CTG8"/>
    <dbReference type="OMA" id="WKPRILM"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00886">
        <property type="entry name" value="HIGHMOBLTY12"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="86"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="86"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="153"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="182" mass="20155" checksum="D78858A9128BEAED" modified="2005-04-12" version="1">MSNQINLPGGLPGLSVPQPPGSMPSGVGSSTNSDAIIVDILCEFADFFVDLASNVAARTGKMWKPRILLQQKSKRSIRAPEDPNKPKRPHTAYTLWCEHIRQKVRENDPNRALQMKDLAEMWNSLPEQEKGPWERKAQEFKQKYLAEMAAYRASGPTSVGGGPSPSAQQQMQPFSSTSMTGW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTH1</accession>
    <name>Q5CTH1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_3040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88710.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626498.1">
        <property type="nucleotide sequence ID" value="XM_626498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTH1"/>
    <dbReference type="GeneID" id="3373570"/>
    <dbReference type="KEGG" id="cpv:cgd2_3040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3040"/>
    <dbReference type="InParanoid" id="Q5CTH1"/>
    <dbReference type="OrthoDB" id="340255at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88710.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="164" mass="18047" checksum="FE94CCB1862B6639" modified="2005-04-12" version="1">MLCSKTEALKQEKPDIFSLAYNDDICSTAKNLKSLDDMESELVVSSCVMLVEYLLTHKQKRNLKFEVGFLPAPLSLISSASTLGNYEFKGNGPCALTLSMYFIKTCGRACNVNRPIVAGVSSIPVSCMSQCSQYSKDFCMVGCKRYGCSVEYYDCMNLLCGTSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTP5</accession>
    <name>Q5CTP5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_2190</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88911.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626424.1">
        <property type="nucleotide sequence ID" value="XM_626424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTP5"/>
    <dbReference type="STRING" id="353152.Q5CTP5"/>
    <dbReference type="GeneID" id="3373673"/>
    <dbReference type="KEGG" id="cpv:cgd2_2190"/>
    <dbReference type="InParanoid" id="Q5CTP5"/>
    <dbReference type="OMA" id="WYSMING"/>
    <dbReference type="OrthoDB" id="331948at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="61"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="160"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="234"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="115"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88911.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="413" mass="47546" checksum="4307844FC45B6269" modified="2005-04-12" version="1" fragment="single">LLDLYGNNYNGMMNIFSRPNWFVYDICGILCMILTELLLLYSALILNFFFIKKFLDSGERILFIFNLILCNSIYIICSFCHLSCTTTDPGVMPNNGDKGEILLPIELQTQTVSIRSCAKCNNLKPPRTHHCSVCKRCIFKMDHHCPWINNCVGINNQKHFLLFLAYVFLFCAYSLILICLRFYKCISYPLPNPSDINDSYLDFQLLSSTTELLNFNQKANETPYYDCTITPISFILGFSVIIEGLIFGIFCIAMFVDQVVCIINNTTGIEHLKQEYLYSKKKSAYSLFIQVFGSKFSWRWFLPTMTRPPFTTSNFDISKFLDFEFGDLIIDPEAGFDCDQSKRDIQSDDSSILLKRMKSNRISCCFICEGIDSSNMSIPNVSEDFSIFENEVRRKGGTSNPSFKEILMDDLHR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTP9</accession>
    <name>Q5CTP9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88779.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626420.1">
        <property type="nucleotide sequence ID" value="XM_626420.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTP9"/>
    <dbReference type="GeneID" id="3373523"/>
    <dbReference type="KEGG" id="cpv:cgd2_2150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2150"/>
    <dbReference type="InParanoid" id="Q5CTP9"/>
    <dbReference type="OMA" id="KSMEECV"/>
    <dbReference type="OrthoDB" id="335890at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88779.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="135" mass="15959" checksum="D35DAA2A0D538A33" modified="2005-04-12" version="1">METLRNATCVPHISGKLIFGYSSNLRSLNECESKWNMLCDVEKSRFIKISKMIRDDILIGLTPLQNWNNSRCSRYSQNTLFYFMNYPSQIFLFPHLAENQILVKCGKKFNLIKKEKLIFEIIDKSLEKLTKYEYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTQ2</accession>
    <name>Q5CTQ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">High mobility group small protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_2120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626417.1">
        <property type="nucleotide sequence ID" value="XM_626417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTQ2"/>
    <dbReference type="FunCoup" id="Q5CTQ2">
        <property type="interactions" value="136"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTQ2"/>
    <dbReference type="GeneID" id="3373674"/>
    <dbReference type="KEGG" id="cpv:cgd2_2120"/>
    <dbReference type="InParanoid" id="Q5CTQ2"/>
    <dbReference type="OMA" id="MKNMGGK"/>
    <dbReference type="OrthoDB" id="1919336at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.30.10">
        <property type="entry name" value="High mobility group box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009071">
        <property type="entry name" value="HMG_box_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050342">
        <property type="entry name" value="HMGB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112">
        <property type="entry name" value="HIGH MOBILITY GROUP PROTEIN DSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48112:SF22">
        <property type="entry name" value="MITOCHONDRIAL TRANSCRIPTION FACTOR A, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00505">
        <property type="entry name" value="HMG_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00398">
        <property type="entry name" value="HMG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50118">
        <property type="entry name" value="HMG_BOX_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HMG box" evidence="4">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="DNA-binding region" description="HMG box" evidence="2">
        <location>
            <begin position="26"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="68"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50118"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="98" mass="11138" checksum="78ED22EF2C24385B" modified="2005-04-12" version="1" fragment="single">KLKMTQNIKTKKATKVSKKEAKKNKPKRAMTAFMYFASSRRAEITAANPSLRSQVAEVAKILGEEWRGMSESDKAPFQKQADADKKRYEREKAQMAGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTR4</accession>
    <name>Q5CTR4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626405.1">
        <property type="nucleotide sequence ID" value="XM_626405.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTR4"/>
    <dbReference type="GeneID" id="3373733"/>
    <dbReference type="KEGG" id="cpv:cgd2_1980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1980"/>
    <dbReference type="InParanoid" id="Q5CTR4"/>
    <dbReference type="OMA" id="DTECIAD"/>
    <dbReference type="OrthoDB" id="342839at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="370" mass="42913" checksum="02A94C9A13978290" modified="2005-04-12" version="1">MFKGNVIDFNRYSTLIDERLKIKSKERMRPNDLFSDPYYQKSDFEKNCIDTISENTSKNMLKNIWNLSQEKANINPSETSSNCNKFYNYENYLGIKRSGCKNTTVEKKSESKMEEFIKNTSARKQKLFREFSTGIVLGDEGDSREKMFSYVSNILSNQNNKEKDDNENFKLAYPFYSNIFNIENHTCKSELSKRFLLERRITNNSDIGDECAAMLLTPGTLKYYSFDRETKTYNAIKDLSNNNISDEYNLDNVTPKFTPLQKNLSSKLHGSDFYNNAAIRSSETMYIIRFRLKNISSQINEKIIKNAAANCGAFAYQIMFEFDPIKWCSKGIATGMLRYSGDSLDAFKRELIELFKIEVEILNGIQESSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU32</accession>
    <name>Q5CU32_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BRCT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88887.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626287.1">
        <property type="nucleotide sequence ID" value="XM_626287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU32"/>
    <dbReference type="GeneID" id="3373391"/>
    <dbReference type="KEGG" id="cpv:cgd2_500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_500"/>
    <dbReference type="InParanoid" id="Q5CU32"/>
    <dbReference type="OMA" id="DFNIERM"/>
    <dbReference type="OrthoDB" id="340020at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="1">
        <location>
            <begin position="187"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88887.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="475" mass="56086" checksum="247A67A9F3845DF3" modified="2005-04-12" version="1">MNSEIWNNKRFLLSGFEENDENNLIRKKYIENNGGTVLELNSEIMDDDVDYLICNYSKGYRYRHTSIDYQKLRTPFWIWLSVNDEWNYSLEWHPFFRPNGNFKYNILKGFQIYIIGYSKTIGGFNNREKSPKYIRKKDDIGILVSFVETQMGARVIFDDDNKNENESNDDNDLVKVPLKASVTKLALICNNEEFEGEIIDKVKEKNNIQTIVNLDWLFDCYEEGRIVSYKKYIYNSKREKEKREEEKMRINAGLKKENNSIANVKYKMIISHQVYLKHIEIYNIMIKINNIEYMEVGRPSREIMKFIQNIDGKNGLNFDENTVIVLVFNDPMEEQDFWYDLVNILEESVVFNIKLASKEKKDKILHHFQMMRIINDPEDFINKLIGCEENIIPLISKLGSKVGYSIPSFINELLKSESEFLDTVLKFTDFENITGLSGFVEYSNDNPMDIVNLNRSKAIKRFDSFEKEFSTIKFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU87</accession>
    <name>Q5CU87_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_3800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88973.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626927.1">
        <property type="nucleotide sequence ID" value="XM_626927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU87"/>
    <dbReference type="GeneID" id="3373852"/>
    <dbReference type="KEGG" id="cpv:cgd3_3800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3800"/>
    <dbReference type="InParanoid" id="Q5CU87"/>
    <dbReference type="OMA" id="WRFRNKT"/>
    <dbReference type="OrthoDB" id="339404at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88973.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="461" mass="51972" checksum="7B416A08262EB155" modified="2005-04-12" version="1">MDGIQENFSKTLDIDCNSSISSVVLTEFYAFVGLIGEESNVNVYCYKDHEDNKDKNYKPKYILENNHGGISKLVLSPCKNLLMGLTCYGWIYIWNIEQLGNNTNNDVEMSIEENNNKSNIKSNINELTEEIPVIKPDIFFMNGHPGDSICVEFINSKIIIAAGINPGSSITFISVKTGKRVGQYISRKNEISGLAWPMYYKFDEKEIKEQNFELAVFSFTNIAIERSSSSGGCWIALGGSNGLITLIYLPFATISKFEKLYETINIENEDINLSNTEFLWKCHQVSELSTEIKSLIWRPRNNNNTGLCLVYGTDDSLLRYCFIEAENKNIMIKKVNLVKITDGTSTCSEINSISFPMDGQNNSILAVGFNRFSSAKRHPIFATSENLTKKSQSFSSFKVYIQDVITYSNNSNNATSSTYTHFYCIGNHYDIITSVHISPCCRYIASSSIDGHVHIYKKSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUE2</accession>
    <name>Q5CUE2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">histone acetyltransferase</fullName>
            <ecNumber evidence="3">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd3_3190</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="16" key="2">
        <citation type="submission" date="2013-06" db="PDB data bank">
            <title>Crystal Structure of CpBRD2 from cryptosporidium, cgd3_3190.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Loppnau P."/>
                <person name="Fonseca M."/>
                <person name="Knapp S."/>
                <person name="Tempel W."/>
                <person name="Bountra C."/>
                <person name="Arrowsmith C.H."/>
                <person name="Edwards A.M."/>
                <person name="Hui R."/>
                <person name="Mottaghi K."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 541-655</scope>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family. GCN5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626872.1">
        <property type="nucleotide sequence ID" value="XM_626872.1"/>
    </dbReference>
    <dbReference type="PDB" id="4LDF">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B=541-655"/>
    </dbReference>
    <dbReference type="PDBsum" id="4LDF"/>
    <dbReference type="AlphaFoldDB" id="Q5CUE2"/>
    <dbReference type="SMR" id="Q5CUE2"/>
    <dbReference type="STRING" id="353152.Q5CUE2"/>
    <dbReference type="GeneID" id="3373877"/>
    <dbReference type="KEGG" id="cpv:cgd3_3190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3190"/>
    <dbReference type="InParanoid" id="Q5CUE2"/>
    <dbReference type="OMA" id="LMECYIS"/>
    <dbReference type="OrthoDB" id="1937912at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CUE2"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000123">
        <property type="term" value="C:histone acetyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010484">
        <property type="term" value="F:histone H3 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05509">
        <property type="entry name" value="Bromo_gcn5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000004">
        <property type="entry name" value="Histone acetyltransferase KAT2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037800">
        <property type="entry name" value="GCN5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750">
        <property type="entry name" value="GH11602P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45750:SF3">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="16" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7" id="KW-0010">Activator</keyword>
    <keyword evidence="10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 11" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0804">Transcription</keyword>
    <keyword evidence="5" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="13">
        <location>
            <begin position="270"/>
            <end position="417"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="12">
        <location>
            <begin position="565"/>
            <end position="635"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008607"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK89017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="4LDF"/>
        </source>
    </evidence>
    <sequence length="655" mass="75950" checksum="0E18B4B0FFBF8899" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUK4</accession>
    <name>Q5CUK4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_2490</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89069.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626810.1">
        <property type="nucleotide sequence ID" value="XM_626810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUK4"/>
    <dbReference type="GeneID" id="3373909"/>
    <dbReference type="KEGG" id="cpv:cgd3_2490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2490"/>
    <dbReference type="InParanoid" id="Q5CUK4"/>
    <dbReference type="OrthoDB" id="343627at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89069.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="388" mass="45422" checksum="D3588C6E0511EDE7" modified="2005-04-12" version="1">MKSFFRKSLNPIHNTKSEASQQIKSSLVAINYLSINIDLSSIIFSSGYTPSRLDILNKGFLLLYYTDPYTATMAAWFFEIQGIPAATISGWSLIRICGPITLDEVTEIISFKPFAITFFNYKVKYSWIAVHGIHTKQLLLKYIKNQNWNIVEALHNRNFQDVVEVLEIFNNEEVPNCYNKLEYMFVSLLEKKSYNIDNPDQYRLHQKLVLLSRCSRLTNEIYLNGVYMKNTHESYQSPIKRDLLLAIRKYLYSIPIFTEACISKSSLKSLKTEEWCLGLDEKHIYRRENGCFNDCIETNSNYKAQSNHSVSRNKLLERMLRVILIELITHFRVKYNNSKYPNITEVSELWKIRFGIEVDIIQLFKMAGLYEEIKNIVEATKEIKITRD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUK6</accession>
    <name>Q5CUK6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_2470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626808.1">
        <property type="nucleotide sequence ID" value="XM_626808.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUK6"/>
    <dbReference type="GeneID" id="3373913"/>
    <dbReference type="KEGG" id="cpv:cgd3_2470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2470"/>
    <dbReference type="InParanoid" id="Q5CUK6"/>
    <dbReference type="OMA" id="DCEQFAT"/>
    <dbReference type="OrthoDB" id="20381at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013906">
        <property type="entry name" value="eIF3j"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08597">
        <property type="entry name" value="eIF3_subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="214" mass="24589" checksum="6B0FE903CA270F32" modified="2005-04-12" version="1">MTLTNNVPVVDNWEDLLNSDNEDSFNNNSEFQTNSNNITSTSISNKCFNDYEEQRRCQELVEEMDGNVMDDLFDGFVSQRKSTSKLPGNNSTHAISNLSNQQDAFSNLNLNSYGKVETTAFKIAECIKPALAKSPAWLRFIDICLNEIFQKLDLKDLKTLKKKVDLQLSIREKEEREKSQQKKKPNDFSTLSKNFREELDIFDGIDSLDESDDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUQ1</accession>
    <name>Q5CUQ1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Pre-mRNA-splicing factor 38</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd3_1920</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Required for pre-mRNA splicing.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PRP38 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89105.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626763.1">
        <property type="nucleotide sequence ID" value="XM_626763.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUQ1"/>
    <dbReference type="STRING" id="353152.Q5CUQ1"/>
    <dbReference type="GeneID" id="3374148"/>
    <dbReference type="KEGG" id="cpv:cgd3_1920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1920"/>
    <dbReference type="InParanoid" id="Q5CUQ1"/>
    <dbReference type="OMA" id="LKFPRES"/>
    <dbReference type="OrthoDB" id="190958at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005037">
        <property type="entry name" value="PRP38"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23142">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 38A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03371">
        <property type="entry name" value="PRP38"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0747">Spliceosome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="182"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="182"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU367025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89105.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="261" mass="30163" checksum="D4648B9BA8C06F81" modified="2005-04-12" version="1">MRNEQNSHHKLFSVSSILRDRVFSSIYWKGECFALDSETILDKAVLLDYIGTTYGGDRKATPFLCLLVKLLQIRPSTEIVLEYINNPRFKYLTALGIVYLRLTESSIVIHKSIEHLYQDYRRIRIRNLDGSFDIIHLDELVEICLCEKKFLDLDFPYIHKRAVLVKQGHLKFPRKSMLEYVPSNSGGSSPISKTENESNIKRRKSFSRSPSVSSIEGNNTQNPGKEKARKTSIYSSKNELSLSVEQWNVYRKKLGLKPLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUS4</accession>
    <name>Q5CUS4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626740.1">
        <property type="nucleotide sequence ID" value="XM_626740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUS4"/>
    <dbReference type="GeneID" id="3374015"/>
    <dbReference type="KEGG" id="cpv:cgd3_1680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1680"/>
    <dbReference type="InParanoid" id="Q5CUS4"/>
    <dbReference type="OrthoDB" id="343703at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="190"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="36"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="209" mass="24335" checksum="A6A68423DFAFC5FB" modified="2005-04-12" version="1">MFLFEKQKCILQLLKTKYRKRKCDSLPRIISVSLSCRRIMKQIENLEKSLEKLTEQIKKLERYILNCFLSAIKMLWKEGREQSFEIDEEAAKECDYKELYLIWQEQQLLKKYKTLLNSFTTSSFGKKASRSSNTSCFCRKTQSAKCKKYAFKRFLLTLEKVEAKIKSLTVEFVSCASYLTLNGISNNEAEPTNENRPASLIGSLGELLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUW3</accession>
    <name>Q5CUW3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ribosomal protein L14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_1250</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89300.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626701.1">
        <property type="nucleotide sequence ID" value="XM_626701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUW3"/>
    <dbReference type="FunCoup" id="Q5CUW3">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUW3"/>
    <dbReference type="GeneID" id="3374065"/>
    <dbReference type="KEGG" id="cpv:cgd3_1250"/>
    <dbReference type="InParanoid" id="Q5CUW3"/>
    <dbReference type="OMA" id="KLCFVVD"/>
    <dbReference type="OrthoDB" id="1875589at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23702">
        <property type="entry name" value="eL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014722">
        <property type="entry name" value="Rib_uL2_dom2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039660">
        <property type="entry name" value="Ribosomal_eL14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002784">
        <property type="entry name" value="Ribosomal_eL14_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11127:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01929">
        <property type="entry name" value="Ribosomal_L14e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL14" evidence="4">
        <location>
            <begin position="49"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006592"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89300.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="125" mass="14322" checksum="7C2BFBCDA4BF414B" modified="2005-04-12" version="1" fragment="single">KMTLFTRFVEPGRLCRIQYGPDTGKMCFIIDVINMNRILIDGPSTNVARQSIPLKRLALTDFKAKIPRGARTGTVKKILEKDNTIENFNKTTYGQKCAAKIFKANMTDFERHALLVARKKRQYLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUY8</accession>
    <name>Q5CUY8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89175.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626676.1">
        <property type="nucleotide sequence ID" value="XM_626676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUY8"/>
    <dbReference type="GeneID" id="3374179"/>
    <dbReference type="KEGG" id="cpv:cgd3_960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_960"/>
    <dbReference type="InParanoid" id="Q5CUY8"/>
    <dbReference type="OrthoDB" id="343044at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="81"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89175.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="186" mass="21429" checksum="C7FE80D978946128" modified="2005-04-12" version="1">MSWNPSVIHCKYAKLLFQFLIFFIDNVCTLVLCGKRSQLEDNADYKIDFFRNTGKYPSTGYLESNGLYGTPLILKSQDSTLWIILFGVCLAAFIFGIGIFMIANFGGNLKHSEDKLAELESNEYFYDPLESPEEEIKRLNKLQGKFVSTLNYPNPNNYNHCHHPQFSQFGNYYSSNQQYYSSSSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV17</accession>
    <name>Q5CV17_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626647.1">
        <property type="nucleotide sequence ID" value="XM_626647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV17"/>
    <dbReference type="GeneID" id="3373812"/>
    <dbReference type="KEGG" id="cpv:cgd3_620"/>
    <dbReference type="InParanoid" id="Q5CV17"/>
    <dbReference type="OMA" id="KFAWIVF"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="54"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="82"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="105"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="207"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="242" mass="29135" checksum="67FEB31E846EDBCA" modified="2005-04-12" version="1" fragment="single">VFLSKGIPPLIKFPIFAGMVVFAVKLPVEELESLISIFSSCLSLFSFFSPSFSFSPFSFLFILFFGLLLFFYLFVHLFFILFFLRFLFVLLFILCHLFILHLLFVLFILCLLFIFLFILCLLFFIRFLFFLRFLFVLFILCHLFILHLLFVLFIICLLFFIRFLFVLFILCHLFILHLLFVLFILCLLSFLYLLFSLLFFLHFLFVLLLFVLLFILCLLFIICLLFALLFLLPLYWVVYLTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV35</accession>
    <name>Q5CV35_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">C-type lectin containing protein with a transmembrane domain and mucin-like rich regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626629.1">
        <property type="nucleotide sequence ID" value="XM_626629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV35"/>
    <dbReference type="STRING" id="353152.Q5CV35"/>
    <dbReference type="GeneID" id="3373807"/>
    <dbReference type="KEGG" id="cpv:cgd3_440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_440"/>
    <dbReference type="InParanoid" id="Q5CV35"/>
    <dbReference type="OrthoDB" id="342156at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0430">Lectin</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="280"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="95"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="18"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="118"/>
            <end position="165"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="445" mass="49069" checksum="4D7CDA2B9424531F" modified="2005-04-12" version="1">MKLIGLSAQPTYHPLDRSSSGSFESDSTESGRANEERNDTLEEMIYKQSSDSIEDILVPVTKPIFSDYSSIGRNSGVEEVYSSNVSTISSKGVVFPNTTTSSDNDFTKNNPANSSKHTSTSTTTNTTTTTTRTTTTTTTTTTTTTTTTTTTTETTTTKKSTTATKNTTTTLRPRFYTTGKSLYTPKTENVRTSAYVKKNSNSLTGNNIVKRDSGIIDMNSDKEAENSLLGFGAGEYVNSESDDPQETQELSYLNEAGQVKMEKSIEGHFDVIERTVNKKLIIGVVIGILLILLILMFCCVFFLRRRSDDTESAQNVDNSNKEIIRNKLNSLQLASIKPILARKGSKIVHMSQKSISYDSNIAPPEKKSIVSVEDTTFSPEYMNSGEGGEAEKTIPYYVAQSQANTLQLHSGRNINLGYDTRPQTQKQAVLKSPKYHDFFYSESSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV69</accession>
    <name>Q5CV69_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Signal peptide, 4+ transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_5220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the OST3/OST6 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627400.1">
        <property type="nucleotide sequence ID" value="XM_627400.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV69"/>
    <dbReference type="SMR" id="Q5CV69"/>
    <dbReference type="STRING" id="353152.Q5CV69"/>
    <dbReference type="GeneID" id="3374222"/>
    <dbReference type="KEGG" id="cpv:cgd8_5220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5220"/>
    <dbReference type="InParanoid" id="Q5CV69"/>
    <dbReference type="OMA" id="KVPDYPY"/>
    <dbReference type="OrthoDB" id="342809at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008250">
        <property type="term" value="C:oligosaccharyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0018279">
        <property type="term" value="P:protein N-linked glycosylation via asparagine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021149">
        <property type="entry name" value="OligosaccharylTrfase_OST3/OST6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692">
        <property type="entry name" value="DOLICHYL-DIPHOSPHOOLIGOSACCHARIDE--PROTEIN GLYCOSYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12692:SF0">
        <property type="entry name" value="GH11935P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04756">
        <property type="entry name" value="OST3_OST6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 10" id="KW-0732">Signal</keyword>
    <keyword evidence="4 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254268" evidence="10">
        <location>
            <begin position="28"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="214"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="259"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="291"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002791"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="343" mass="39644" checksum="FEB35DD58C6AE857" modified="2005-04-12" version="1">MVDLFRAALLFPLFLIIICISLPFTECERIHELTKLKQESPNSLINFNFTGYQHFVLMDGRDYDLVILYTGTKKSCPSCVTSSNNFEVAAKNYYKQLKPNQKIFFGYLYVDKVENVVGIHKLRFLPAIIYIESTKQFITSSLSFSRESQWRIPEQKDISSVAMIKFLNSRTGNNFEIILSFEEKVKRISMLIFLLIVSILCIYNIIMLARNKPFIIMILAIIACSISMSGIVYSIQHGKYQSRDFFVQNPRVQNLHEGMLMSILMTLSSLFLFLTPFVIHGKIFIFKRKIPGWSALILLISFIFSVLCIYFGYKMKVSWYAPTFYPPPGYLKGPLLVDRGNSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV86</accession>
    <name>Q5CV86_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_5010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89628.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627383.1">
        <property type="nucleotide sequence ID" value="XM_627383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV86"/>
    <dbReference type="GeneID" id="3374205"/>
    <dbReference type="KEGG" id="cpv:cgd8_5010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5010"/>
    <dbReference type="InParanoid" id="Q5CV86"/>
    <dbReference type="OMA" id="IGSANCG"/>
    <dbReference type="OrthoDB" id="340407at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="48"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="77"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="117"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89628.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="171" mass="18788" checksum="1D9B32F2BF49EB77" modified="2005-04-12" version="1">MCYLGSSTHGRCCCCIPLGISGTITSLILLASGIFTTCQFSQTPNQEIGGLTSSALFTGVTLLSFLCFYCGPGGAGFAYFATQFSAIVVTFQLIYQWCLWSYSFLQVGHFLIGFKMAFIITMIWIVTLIVNIISITIFRSTWEIKIQGGSTWNLKNAQEVRLKNLENAVGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVB2</accession>
    <name>Q5CVB2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Palmitoyltransferase</fullName>
            <ecNumber evidence="10">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_4730</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="10">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627357.1">
        <property type="nucleotide sequence ID" value="XM_627357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVB2"/>
    <dbReference type="STRING" id="353152.Q5CVB2"/>
    <dbReference type="GeneID" id="3374455"/>
    <dbReference type="KEGG" id="cpv:cgd8_4730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4730"/>
    <dbReference type="InParanoid" id="Q5CVB2"/>
    <dbReference type="OMA" id="IYHSYLC"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006612">
        <property type="term" value="P:protein targeting to membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883:SF301">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22883">
        <property type="entry name" value="ZINC FINGER DHHC DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="8" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0564">Palmitate</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10 12" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="32"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="465"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="11">
        <location>
            <begin position="384"/>
            <end position="507"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="562" mass="64239" checksum="9B5E3B67F7883B78" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVB3</accession>
    <name>Q5CVB3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">serine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.11</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Seryl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_4720</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="submission" date="2019-05" db="PDB data bank">
            <title>Crystal Structure of Seryl-tRNA synthetase (SerRS) from Cryptosporidium parvum complexed with L-Serylsulfamoyl Adenosine.</title>
            <authorList>
                <person name="Dranow D.M."/>
                <person name="Abendroth J."/>
                <person name="Lorimer D.D."/>
                <person name="Horanyi P.S."/>
                <person name="Edwards T.E."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) IN COMPLEX WITH MG(2+)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.11" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627356.1">
        <property type="nucleotide sequence ID" value="XM_627356.1"/>
    </dbReference>
    <dbReference type="PDB" id="6OTE">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.95 A"/>
        <property type="chains" value="A=1-454"/>
    </dbReference>
    <dbReference type="PDBsum" id="6OTE"/>
    <dbReference type="AlphaFoldDB" id="Q5CVB3"/>
    <dbReference type="SMR" id="Q5CVB3"/>
    <dbReference type="FunCoup" id="Q5CVB3">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVB3"/>
    <dbReference type="GeneID" id="3374454"/>
    <dbReference type="KEGG" id="cpv:cgd8_4720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4720"/>
    <dbReference type="InParanoid" id="Q5CVB3"/>
    <dbReference type="OMA" id="GYTPCFR"/>
    <dbReference type="OrthoDB" id="10264585at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004828">
        <property type="term" value="F:serine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006434">
        <property type="term" value="P:seryl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00770">
        <property type="entry name" value="SerRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000026">
        <property type="entry name" value="Seryl-tRNA synthetase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.40">
        <property type="entry name" value="Serine-tRNA synthetase, tRNA binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002317">
        <property type="entry name" value="Ser-tRNA-ligase_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015866">
        <property type="entry name" value="Ser-tRNA-synth_1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042103">
        <property type="entry name" value="SerRS_1_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033729">
        <property type="entry name" value="SerRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010978">
        <property type="entry name" value="tRNA-bd_arm"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00414">
        <property type="entry name" value="serS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11778">
        <property type="entry name" value="SERYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02403">
        <property type="entry name" value="Seryl_tRNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001529">
        <property type="entry name" value="Ser-tRNA-synth_IIa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00981">
        <property type="entry name" value="TRNASYNTHSER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46589">
        <property type="entry name" value="tRNA-binding arm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="7 12" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="11">
        <location>
            <begin position="150"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="250"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="281"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="355"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="368"/>
            <end position="371"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="368"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="404"/>
        </location>
        <ligand>
            <name>L-serine</name>
            <dbReference type="ChEBI" id="CHEBI:33384"/>
        </ligand>
    </feature>
    <feature type="site" description="Important for serine binding" evidence="9">
        <location>
            <position position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031113"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001529-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="6OTE"/>
        </source>
    </evidence>
    <sequence length="454" mass="52064" checksum="3B80705763CFA3D2" modified="2005-04-12" version="1">MPIDINRIRVEKGGDYQKIAESEMARYKGLETLEELVKVDQKWREDMFKLEQSKKELNSISKEIAQIKKKDPKADCKDLQDKSVQLKKNLPIIEKQALETEEVRDKLWHKIGNVLQPDVPISNTEDDNLVLRTWGEIPDIKVDGTPGKLHHNEIMSRLGFYDSVKGAELAGHRGYFLKDYGVIMSMALSHYAMGFLLKKGYLAIQPPYFMKRDLMGKAAELQDFEETLYHIPSDNSKGEVDSNSLFLIATSEQPIAAMHHNVTLEDKDLPIKYAGISTCFRKEAGAHGKDTWGIFRIHQFEKVEQFCVTLPEDSQKIHEEMISISEEFYQSLELPYRVISIVSGALNDAASKKYDLEAWFPGYNSYRELVSCSNCTDYQSRALECRLGFRKEGEREKHYCHFLNGTLCAIQRTMCCIVENYQTPDGLRIPKVLQPYMNGVEFIPFKNETATCAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVC3</accession>
    <name>Q5CVC3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Nudix hydrolase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627346.1">
        <property type="nucleotide sequence ID" value="XM_627346.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVC3"/>
    <dbReference type="GeneID" id="3374444"/>
    <dbReference type="KEGG" id="cpv:cgd8_4610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4610"/>
    <dbReference type="InParanoid" id="Q5CVC3"/>
    <dbReference type="OrthoDB" id="343877at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="1">
        <location>
            <begin position="10"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="207" mass="24572" checksum="F7151D9BAD300F78" modified="2005-04-12" version="1">MKMKNNNYPNKFRSFIIVIHQEYGCLLLKSTKKSEYGIFQLPGGRLDEKDLMINISEANNNNGRINPIPAENDFKIAAARELYEETGLDFRNRLYMLKPLKFDLPNKWRFFYLNITNYEIVNQNQNKNYYFNIFKEISQYFNSIIFKTKNNNIDVNNIIIKLSKEHESFLFEKDLVKASQLVKSHSKGVCSKALLLFQQNYQIYTNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVD0</accession>
    <name>Q5CVD0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_4540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89589.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627339.1">
        <property type="nucleotide sequence ID" value="XM_627339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVD0"/>
    <dbReference type="STRING" id="353152.Q5CVD0"/>
    <dbReference type="GeneID" id="3374544"/>
    <dbReference type="KEGG" id="cpv:cgd8_4540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4540"/>
    <dbReference type="InParanoid" id="Q5CVD0"/>
    <dbReference type="OMA" id="CDNDIMS"/>
    <dbReference type="OrthoDB" id="363951at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43941:SF1">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="687"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="767"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="363"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="636"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="687"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="715"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="767"/>
            <end position="779"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89589.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="786" mass="90044" checksum="2A80977EF4C3255A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVL3</accession>
    <name>Q5CVL3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Niemann-Pick type C1 disease protein/ patched like cholesterol transporter of the SecD family, 12 transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_3640</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the patched family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89524.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627256.1">
        <property type="nucleotide sequence ID" value="XM_627256.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3374308"/>
    <dbReference type="KEGG" id="cpv:cgd8_3640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3640"/>
    <dbReference type="InParanoid" id="Q5CVL3"/>
    <dbReference type="OMA" id="LCAMRCA"/>
    <dbReference type="OrthoDB" id="6510177at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1640.10">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053958">
        <property type="entry name" value="HMGCR/SNAP/NPC1-like_SSD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051697">
        <property type="entry name" value="Patched_domain-protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000731">
        <property type="entry name" value="SSD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796">
        <property type="entry name" value="PATCHED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10796:SF92">
        <property type="entry name" value="PATCHED-RELATED, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12349">
        <property type="entry name" value="Sterol-sensing"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82866">
        <property type="entry name" value="Multidrug efflux transporter AcrB transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50156">
        <property type="entry name" value="SSD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="480"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="512"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="540"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="758"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="792"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1007"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1279"/>
            <end position="1301"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1308"/>
            <end position="1328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1334"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1381"/>
            <end position="1399"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1405"/>
            <end position="1433"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="4">
        <location>
            <begin position="762"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="domain" description="SSD" evidence="4">
        <location>
            <begin position="1313"/>
            <end position="1431"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="645"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="645"/>
            <end position="659"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89524.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1465" mass="167662" checksum="622EE15CA2AEB8AC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVQ1</accession>
    <name>Q5CVQ1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">HTH La-type RNA-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_3220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627218.1">
        <property type="nucleotide sequence ID" value="XM_627218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVQ1"/>
    <dbReference type="STRING" id="353152.Q5CVQ1"/>
    <dbReference type="GeneID" id="3374245"/>
    <dbReference type="KEGG" id="cpv:cgd8_3220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3220"/>
    <dbReference type="InParanoid" id="Q5CVQ1"/>
    <dbReference type="OMA" id="FFHKQIS"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.450.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006630">
        <property type="entry name" value="La_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11523">
        <property type="entry name" value="DUF3223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05383">
        <property type="entry name" value="La"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00715">
        <property type="entry name" value="LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50961">
        <property type="entry name" value="HTH_LA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="HTH La-type RNA-binding" evidence="3">
        <location>
            <begin position="29"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00332"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50961"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="385" mass="44140" checksum="5DFA3348A0A5844D" modified="2005-04-12" version="1">MTEIKKIRSRSPSPIGGNCEPKRIKADSIVIGKETRFSLIKQLEYYFSDENLKTDSFFQNIMRSDPENRLLVSYLLNCSKIKNLGITKEEEIIDALKGHEVILIEFNQEGKAMIKLNKNLPDLESKKKTKEKNLINSKDLHAGGCILKIINLPETASWSSVKDSIKEKLKELQPESQNLIRYVSQTTQDGTCYILLKPFKNDKSLIENMELAFGEENISISLASQDEARKIINSVFPRHIQKEREKELNKQKMAFMSMPIVVGGQTFASIEHLRRCIKEVLEQSEVNTVFEKESLTYKVLLSILEYHPKREKKTKGIDSICIRIHENSTNKDDLCSKCFYIVRKSPDGIEEFEDFSINKCLQQLSRNPPLSSKLEEALIENGAEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVY7</accession>
    <name>Q5CVY7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">AN1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_2290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627132.1">
        <property type="nucleotide sequence ID" value="XM_627132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVY7"/>
    <dbReference type="STRING" id="353152.Q5CVY7"/>
    <dbReference type="GeneID" id="3374488"/>
    <dbReference type="KEGG" id="cpv:cgd8_2290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2290"/>
    <dbReference type="InParanoid" id="Q5CVY7"/>
    <dbReference type="OMA" id="KHIENNC"/>
    <dbReference type="OrthoDB" id="431929at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1110.10">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035896">
        <property type="entry name" value="AN1-like_Znf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000058">
        <property type="entry name" value="Znf_AN1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677">
        <property type="entry name" value="ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14677:SF20">
        <property type="entry name" value="ZINC FINGER AN1-TYPE CONTAINING 2A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01428">
        <property type="entry name" value="zf-AN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00154">
        <property type="entry name" value="ZnF_AN1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF118310">
        <property type="entry name" value="AN1-like Zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="AN1-type" evidence="4">
        <location>
            <begin position="11"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="AN1-type" evidence="4">
        <location>
            <begin position="72"/>
            <end position="108"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="263" mass="29711" checksum="581FE07F5F48E1CF" modified="2005-04-12" version="1">MVEVEEFGIKCSNMECNLIQFLPFECFKCRKKFCIEHVNSGKHMCESKGNDLELDNGFKGGFEEREKASVNCSMNGCSNVGIICRKCNKMLCSEHIYESEHECMGKNRVIISKTALDLKRRYSGGEMLRGSKLPDENKSSKMLRKIMIKSKSIGDSSIPARNRIAVALYVSSGVECLKFVNKDLPICIWLNGEKTVGWNLDYISEKLRVLHGNNKAKFLGLVLFKNKDIQGNEIPEKKILEMSVELRKCVSDGESLLLDYGLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW52</accession>
    <name>Q5CW52_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sugar phosphate permease with 11 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_1600</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627067.1">
        <property type="nucleotide sequence ID" value="XM_627067.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW52"/>
    <dbReference type="STRING" id="353152.Q5CW52"/>
    <dbReference type="GeneID" id="3374479"/>
    <dbReference type="KEGG" id="cpv:cgd8_1600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1600"/>
    <dbReference type="InParanoid" id="Q5CW52"/>
    <dbReference type="OMA" id="FKQYQAM"/>
    <dbReference type="OrthoDB" id="342060at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY TRANSPORTER 16, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43184:SF30">
        <property type="entry name" value="MFS DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="216"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="275"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="306"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="593"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="628"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="660"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="685"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="728"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="758"/>
            <end position="777"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="7">
        <location>
            <begin position="150"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="463"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="531"/>
            <end position="558"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="464"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="540"/>
            <end position="553"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="789" mass="88521" checksum="DED44C8DBA566C7C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW76</accession>
    <name>Q5CW76_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627043.1">
        <property type="nucleotide sequence ID" value="XM_627043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW76"/>
    <dbReference type="GeneID" id="3374513"/>
    <dbReference type="KEGG" id="cpv:cgd8_1360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1360"/>
    <dbReference type="InParanoid" id="Q5CW76"/>
    <dbReference type="OrthoDB" id="339119at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="106"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="140"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="625" mass="70910" checksum="E721E0510B9BDAFD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWH5</accession>
    <name>Q5CWH5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_5060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627829.1">
        <property type="nucleotide sequence ID" value="XM_627829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWH5"/>
    <dbReference type="STRING" id="353152.Q5CWH5"/>
    <dbReference type="GeneID" id="3375827"/>
    <dbReference type="KEGG" id="cpv:cgd6_5060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5060"/>
    <dbReference type="InParanoid" id="Q5CWH5"/>
    <dbReference type="OMA" id="IFESECH"/>
    <dbReference type="OrthoDB" id="504170at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00180">
        <property type="entry name" value="PKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895">
        <property type="entry name" value="CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE KINASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43895:SF32">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE CHK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="197"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="226"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK90082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="669" mass="76551" checksum="502C87E88BDE3202" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWH6</accession>
    <name>Q5CWH6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_5050</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90080.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627828.1">
        <property type="nucleotide sequence ID" value="XM_627828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWH6"/>
    <dbReference type="GeneID" id="3375825"/>
    <dbReference type="KEGG" id="cpv:cgd6_5050"/>
    <dbReference type="InParanoid" id="Q5CWH6"/>
    <dbReference type="OrthoDB" id="329737at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="199"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="223"/>
            <end position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90080.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="257" mass="29372" checksum="AF7E07D4212CF83A" modified="2005-04-12" version="1">MTSDFSAVSVSKVNSRISKVPVIMFSPSIINFRRFTFSRMELEPERFQSLMIVQSLNDKIVPTRDIMELVSGFDETQVRTHFVQGVGTLLPTYASLSSEQLRMYMVEILQMASEDNGITSDSQSINVTEMQRFSNKSDAMEQGINKLVSNRLQTMHTFTDYNYGINLPSLRKPISLISRSPRNSYSKYKSLSSELRDAGYSQDNELDENEQSPLIESREKLTSRSIYNPKPSNASELFSQLEHIKEDDSSEYYSDKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWI4</accession>
    <name>Q5CWI4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_4950</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627820.1">
        <property type="nucleotide sequence ID" value="XM_627820.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWI4"/>
    <dbReference type="GeneID" id="3375818"/>
    <dbReference type="KEGG" id="cpv:cgd6_4950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4950"/>
    <dbReference type="InParanoid" id="Q5CWI4"/>
    <dbReference type="OMA" id="GCEKREF"/>
    <dbReference type="OrthoDB" id="336435at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="262" mass="30382" checksum="103C6E8ECE8B847E" modified="2007-04-03" version="1">MSETRRSFLGNIANGIGNFIMGSDEKEYNLVNVARASATFAKPIIGQVSEFVESGKNSLSDSFVWKDYHRGYISTEEAIDLASTTAREVESSEPEEFKIRYEEKIKSKSQVFSYPTPRLESLSQAITDSKEKIQKSEFISKIGSCGYNIYHFLKSGSIKVFVNIKELICKAFSFLRNSIRFCDQIIFFLKKNWGIFYKKVNKIILNIKNNPLGYPKKVYYFIYGFFHRIYEKIYHYRHPEVHKSKIAALGSSIKNIGWSWRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWJ4</accession>
    <name>Q5CWJ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Drs1p, eIF4a-1-family RNA SFII helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_4830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627810.1">
        <property type="nucleotide sequence ID" value="XM_627810.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWJ4"/>
    <dbReference type="FunCoup" id="Q5CWJ4">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWJ4"/>
    <dbReference type="GeneID" id="3375917"/>
    <dbReference type="KEGG" id="cpv:cgd6_4830"/>
    <dbReference type="InParanoid" id="Q5CWJ4"/>
    <dbReference type="OMA" id="MIDPPKQ"/>
    <dbReference type="OrthoDB" id="10259843at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17947">
        <property type="entry name" value="DEADc_DDX27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050079">
        <property type="entry name" value="DEAD_box_RNA_helicase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959:SF1">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47959">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE RHLE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3 6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="61"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="278"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="456"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="5">
        <location>
            <begin position="30"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="564"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="573" mass="64324" checksum="DCEA6C44AE20D343" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWM1</accession>
    <name>Q5CWM1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4520</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627783.1">
        <property type="nucleotide sequence ID" value="XM_627783.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWM1"/>
    <dbReference type="GeneID" id="3375789"/>
    <dbReference type="KEGG" id="cpv:cgd6_4520"/>
    <dbReference type="InParanoid" id="Q5CWM1"/>
    <dbReference type="OrthoDB" id="344236at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="241"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="242"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="293"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="507" mass="54645" checksum="4024F04D849C99C5" modified="2007-04-03" version="1">MSQSSTLWNQSYSRELIMDHSEGIDWISGDGCLENIKDSHFVDYSDPNQVNMEDPLGNNFYDCTDLDDSFHNYLMKGLLGENVEGGSGSNNLNDVSSVNSIRGQSNVGVTISHNNDAICHNIDHRIDSVGIGVGSLGGEVGGALGVGLGGVGGGIEIGLGVQVGEVRNQGEKEFENISCSYTGNSHSHQLEPPNEDLVEDQSNCYRISATSNNLGISSNHGLLLGASSSSKVLGATPSAQISSSLSSSSSSSSSSLASSSSSSSSSPSLTLNSGLPPISLPPRAIPPINLSQSLMTPTTSASSSSVSPISFSPNSMQSGQKLMGFDHSFPMENTQKRVRIEPEERIRMGIFDDSLVESDVKFADHQIVELDSSKGRRWSNNSTTSTISSNFSINTSDGGCVSHINDSVNNENLGLMSHDFQQDKFCNTEDLGSQKPKMADQSYEMGVIEDENYSMGGQMEGEFFMNSDNYLTEEEKLKLRRRGRRRRPGKLNISKQLTKDLTLYCFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWR8</accession>
    <name>Q5CWR8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90004.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627736.1">
        <property type="nucleotide sequence ID" value="XM_627736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWR8"/>
    <dbReference type="GeneID" id="3375749"/>
    <dbReference type="KEGG" id="cpv:cgd6_4010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4010"/>
    <dbReference type="InParanoid" id="Q5CWR8"/>
    <dbReference type="OrthoDB" id="342470at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253927" evidence="1">
        <location>
            <begin position="21"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90004.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="161" mass="18746" checksum="52F4180287FB74B2" modified="2007-04-03" version="1">MKKLSSFLFLLFLELQNAWSSLNLSLNSSSRQLIQNNYWNSHFPHIKPIKPGETTKLETGIFKCHTKLKDEKTMRISWECFTKVNNVIWIPNKKTLNEKNKYLISFTDSLGTLYTFPYSPKKLLNLCTSTSIDMFGNFSEKGVAILPKDFKFLTINECINY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWS9</accession>
    <name>Q5CWS9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial carrier protein MRS2 with 2 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_3880</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89997.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627725.1">
        <property type="nucleotide sequence ID" value="XM_627725.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWS9"/>
    <dbReference type="FunCoup" id="Q5CWS9">
        <property type="interactions" value="58"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWS9"/>
    <dbReference type="GeneID" id="3375742"/>
    <dbReference type="KEGG" id="cpv:cgd6_3880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3880"/>
    <dbReference type="InParanoid" id="Q5CWS9"/>
    <dbReference type="OMA" id="IMSATYH"/>
    <dbReference type="OrthoDB" id="409586at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990542">
        <property type="term" value="P:mitochondrial transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002067">
        <property type="entry name" value="MCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045315">
        <property type="entry name" value="Mtm1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45760:SF2">
        <property type="entry name" value="FI19922P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00926">
        <property type="entry name" value="MITOCARRIER"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="121"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="229"/>
            <end position="319"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89997.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="319" mass="36648" checksum="456BC023DF772692" modified="2007-04-03" version="1">MRSIPLKKEDNKDELYHGLRSPIGLTFLNGFAVSLACTPLDVIKNYWIYKDSNEVFNRGFYANKGLSLHKIPKNTNTLRIIRELYRYRGLRTFWTGLLPTMMFNIPSNIIFFNTYYYFLNAMGFSPGIAGIQARTITTLFVSPMEFIRTRVQAQIGDELFLNINRVGAKVNKHRSFLFDSKRYLNIYQLWSGLWITILRDVPFTAVYWTLTEKLRSRIVLQGETDSGPKKTLKLFSIAAFSGTVATLVSHPLDIVKTNIQTHSFNHSLLGKGQISPGRIVSSLFRRRGFQNFYTGVFPRILKIVPSCAISLSLFELCRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWY7</accession>
    <name>Q5CWY7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">RAS small GTpases RIC1/ypt1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_3220</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="7">Endomembrane system</location>
            <topology evidence="7">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89947.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627667.1">
        <property type="nucleotide sequence ID" value="XM_627667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWY7"/>
    <dbReference type="FunCoup" id="Q5CWY7">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWY7"/>
    <dbReference type="GeneID" id="3375692"/>
    <dbReference type="KEGG" id="cpv:cgd6_3220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3220"/>
    <dbReference type="InParanoid" id="Q5CWY7"/>
    <dbReference type="OMA" id="IQQKNNC"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01869">
        <property type="entry name" value="Rab1_Ypt1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000359">
        <property type="entry name" value="Small GTP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057289">
        <property type="entry name" value="Rab1/Ypt1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0636">Prenylation</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="175"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="175"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00037868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="203" mass="22804" checksum="1CA85CC455B340EA" modified="2007-04-03" version="1">MNPEYDYLFKLLLIGDSGVGKSCLLLRFADDTYTDSYISTIGVDFKIRTISLENKTVKLQIWDTAGQERFRTITSSYYRGAHGIIIVYDVTDRDSFDNVKQWIQEIDRYAMENVNKLLVGNKCDLVSKRVVTSDEGRELADSHGIKFIETSAKNAYNVEQAFHTMAGEIKKRVQVNSQNTRGSAQQGPKLAGAQPIRQGGCCS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX13</accession>
    <name>Q5CX13_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein with possible stromal antigen (SA/STAG) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627641.1">
        <property type="nucleotide sequence ID" value="XM_627641.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX13"/>
    <dbReference type="GeneID" id="3376165"/>
    <dbReference type="KEGG" id="cpv:cgd6_2930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2930"/>
    <dbReference type="InParanoid" id="Q5CX13"/>
    <dbReference type="OMA" id="RNDENNT"/>
    <dbReference type="OrthoDB" id="498590at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039662">
        <property type="entry name" value="Cohesin_Scc3/SA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199:SF0">
        <property type="entry name" value="LD34181P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11199">
        <property type="entry name" value="STROMAL ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1311"/>
            <end position="1404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1345"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1365"/>
            <end position="1386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1393"/>
            <end position="1404"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1404" mass="158389" checksum="2FE027D01184DF04" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX49</accession>
    <name>Q5CX49_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha</fullName>
            <ecNumber evidence="4">2.5.1.58</ecNumber>
            <ecNumber evidence="3">2.5.1.59</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="12">CAAX farnesyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">FTase-alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Ras proteins prenyltransferase subunit alpha</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="13">Type I protein geranyl-geranyltransferase subunit alpha</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd6_2510</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein prenyltransferase subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.58" evidence="4"/>
    <dbReference type="EC" id="2.5.1.59" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89896.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627605.1">
        <property type="nucleotide sequence ID" value="XM_627605.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX49"/>
    <dbReference type="STRING" id="353152.Q5CX49"/>
    <dbReference type="GeneID" id="3376136"/>
    <dbReference type="KEGG" id="cpv:cgd6_2510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2510"/>
    <dbReference type="InParanoid" id="Q5CX49"/>
    <dbReference type="OMA" id="WAIRTFN"/>
    <dbReference type="OrthoDB" id="272289at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005953">
        <property type="term" value="C:CAAX-protein geranylgeranyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005965">
        <property type="term" value="C:protein farnesyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004662">
        <property type="term" value="F:CAAX-protein geranylgeranyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004660">
        <property type="term" value="F:protein farnesyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.120">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002088">
        <property type="entry name" value="Prenyl_trans_a"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11129:SF1">
        <property type="entry name" value="PROTEIN FARNESYLTRANSFERASE_GERANYLGERANYLTRANSFERASE TYPE-1 SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01239">
        <property type="entry name" value="PPTA"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48439">
        <property type="entry name" value="Protein prenylyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51147">
        <property type="entry name" value="PFTA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5" id="KW-0637">Prenyltransferase</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0677">Repeat</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00040965"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00043086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00043219"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK89896.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="326" mass="39332" checksum="37A34DAC055288B1" modified="2007-04-03" version="1">MQELDSLENTNIETIEYSVDFQNEGVCKFLFKPDHYALFSKLKSLLDNECFDLENLDISTQVIDLNPQHYTAWYFRRKIIRENYVEHENKTEFLREELRFVRGICERAPKCYQSWWHMRVIRELLGFDIEELNFISKQLEFDAKNMYVWNHRTWFIRKYNSVENDLLISELDFISKLISEDCRNNSAWCYRHFIFTNLKKMNALKESDLLEEVDYIVNWLMFAPHNDSIWNYIISFFSKIMVNGNVNKETLIKNLSLENAPKSFIDAIDEIYTNHYDSCHQVVYIKACMEYEKGDTDFALKAFKLLQSVDPIRKFYWKWRADNLKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX88</accession>
    <name>Q5CX88_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cdc39p protein-like C-terminal Not1, CCR4-Not complex component Not1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_2060</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627566.1">
        <property type="nucleotide sequence ID" value="XM_627566.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CX88">
        <property type="interactions" value="428"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX88"/>
    <dbReference type="GeneID" id="3376076"/>
    <dbReference type="KEGG" id="cpv:cgd6_2060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2060"/>
    <dbReference type="InParanoid" id="Q5CX88"/>
    <dbReference type="OMA" id="IDEYHCY"/>
    <dbReference type="OrthoDB" id="1933107at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060090">
        <property type="term" value="F:molecular adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000288">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20710">
        <property type="entry name" value="NOT1_connector"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.800">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.840">
        <property type="entry name" value="CCR4-NOT transcription complex subunit 1 TTP binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007196">
        <property type="entry name" value="CCR4-Not_Not1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032191">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024557">
        <property type="entry name" value="CNOT1_dom_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032193">
        <property type="entry name" value="CNOT1_TTP_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038535">
        <property type="entry name" value="CNOT1_TTP_bind_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040398">
        <property type="entry name" value="Not1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13162:SF8">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16415">
        <property type="entry name" value="CNOT1_CAF1_bind"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16417">
        <property type="entry name" value="CNOT1_TTP_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12842">
        <property type="entry name" value="DUF3819"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04054">
        <property type="entry name" value="Not1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 TTP binding" evidence="10">
        <location>
            <begin position="776"/>
            <end position="951"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="9">
        <location>
            <begin position="1062"/>
            <end position="1132"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1 CAF1-binding" evidence="9">
        <location>
            <begin position="1166"/>
            <end position="1305"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-NOT transcription complex subunit 1" evidence="8">
        <location>
            <begin position="1425"/>
            <end position="1571"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="7">
        <location>
            <begin position="2264"/>
            <end position="2492"/>
        </location>
    </feature>
    <feature type="domain" description="CCR4-Not complex component Not1 C-terminal" evidence="7">
        <location>
            <begin position="2531"/>
            <end position="2647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1688"/>
            <end position="1712"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF04054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF12842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF16415"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF16417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2664" mass="303872" checksum="603C69C19C64B9D2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXA0</accession>
    <name>Q5CXA0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative coiled-coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_1930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627554.1">
        <property type="nucleotide sequence ID" value="XM_627554.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXA0"/>
    <dbReference type="GeneID" id="3376067"/>
    <dbReference type="KEGG" id="cpv:cgd6_1930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1930"/>
    <dbReference type="InParanoid" id="Q5CXA0"/>
    <dbReference type="OMA" id="FRELQMI"/>
    <dbReference type="OrthoDB" id="339908at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="584"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="343"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="584"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="604" mass="71198" checksum="8909CFECD278EAA6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXC5</accession>
    <name>Q5CXC5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89833.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627529.1">
        <property type="nucleotide sequence ID" value="XM_627529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXC5"/>
    <dbReference type="GeneID" id="3376112"/>
    <dbReference type="KEGG" id="cpv:cgd6_1620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1620"/>
    <dbReference type="InParanoid" id="Q5CXC5"/>
    <dbReference type="OrthoDB" id="342873at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="339"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="245"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="361"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89833.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="361" mass="40616" checksum="4AF48030923F74BB" modified="2007-04-03" version="1">MLPRETNYFNDENNSASLINSSRTEQKLNINDKNTIDSKNLDKIEGKQRCELMLSINTRKEPSIDQLFSGDQAYSRNQSEFERPGFICLKPEPSSISSISKEMRRLCSILTFLFDSKNSGCLEFTEEQFRWHWINILKCTTIEEFSPYQVILAPFETNNLNLIAIEKVICDLNAFYKSELHEKENKALRSVSKRGCKKKNNAVTSVKFDQVLANINDSINLGELNRTRDEIYESSKRSSCDSSSKKKLIKPSRKSISKENAARILRMCLASGASDSSETKNGIKEKNSNELSNKISDICESNDLDNDKELESDKFQVNAGCGAKSGIGEKDCIINSEVDTSGHLPLDNGTSEPINLSVQNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXU4</accession>
    <name>Q5CXU4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90455.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628636.1">
        <property type="nucleotide sequence ID" value="XM_628634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXU4"/>
    <dbReference type="GeneID" id="3372228"/>
    <dbReference type="KEGG" id="cpv:cgd7_4920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4920"/>
    <dbReference type="InParanoid" id="Q5CXU4"/>
    <dbReference type="OMA" id="NTYSESC"/>
    <dbReference type="OrthoDB" id="342705at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="121"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="192"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="240"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="295"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="391"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="434"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="519"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90455.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="557" mass="64426" checksum="FBEA8E85515BE478" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXV5</accession>
    <name>Q5CXV5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">glutathione transferase</fullName>
            <ecNumber evidence="3">2.5.1.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_4780</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>RX + glutathione = an S-substituted glutathione + a halide anion + H(+)</text>
            <dbReference type="Rhea" id="RHEA:16437"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16042"/>
            <dbReference type="ChEBI" id="CHEBI:17792"/>
            <dbReference type="ChEBI" id="CHEBI:57925"/>
            <dbReference type="ChEBI" id="CHEBI:90779"/>
            <dbReference type="EC" id="2.5.1.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GST superfamily. Mu family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.18" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90446.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628625.1">
        <property type="nucleotide sequence ID" value="XM_628623.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXV5"/>
    <dbReference type="STRING" id="353152.Q5CXV5"/>
    <dbReference type="GeneID" id="3372219"/>
    <dbReference type="KEGG" id="cpv:cgd7_4780"/>
    <dbReference type="InParanoid" id="Q5CXV5"/>
    <dbReference type="OMA" id="IENWFEY"/>
    <dbReference type="OrthoDB" id="414243at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004364">
        <property type="term" value="F:glutathione transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006749">
        <property type="term" value="P:glutathione metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004045">
        <property type="entry name" value="Glutathione_S-Trfase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050213">
        <property type="entry name" value="GST_superfamily"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571">
        <property type="entry name" value="GLUTATHIONE S-TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11571:SF222">
        <property type="entry name" value="GLUTATHIONE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50404">
        <property type="entry name" value="GST_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST N-terminal" evidence="6">
        <location>
            <begin position="1"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="GST C-terminal" evidence="7">
        <location>
            <begin position="64"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00047960"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90446.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="161" mass="18760" checksum="DE32BE498175364A" modified="2005-04-12" version="1">MIEYLEHNISGKDFLQPEFQQVLVESGNFPMLPYLSDSNNEVELTGSFTILRYLADKCKLMGKSPEERNKIENWLEYLQSLLHSVWDFENMSDNYTGIQQAKKKSQFLLETLHPMLKCIDEKIEQGIWALESYSVVDIVLYSAISVIIRSWGSDLLKPYIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXY6</accession>
    <name>Q5CXY6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628594.1">
        <property type="nucleotide sequence ID" value="XM_628592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXY6"/>
    <dbReference type="STRING" id="353152.Q5CXY6"/>
    <dbReference type="GeneID" id="3372173"/>
    <dbReference type="KEGG" id="cpv:cgd7_4430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4430"/>
    <dbReference type="InParanoid" id="Q5CXY6"/>
    <dbReference type="OrthoDB" id="10530670at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254628" description="Secreted protein" evidence="2">
        <location>
            <begin position="19"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="109" mass="12337" checksum="2812DD0FE266920C" modified="2005-04-12" version="1">MSSLRLLVFVSLFLGVFTQDQMFLGNPRFTGGLQERIFSSFPAIFNRADNKSSNSTEELEAKPTERPEVPRVEEKGKPQKDEPKNEGTQNSKGKFEIRTKEEKGAARKT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY72</accession>
    <name>Q5CY72_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cgd7_3440 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90344.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628508.1">
        <property type="nucleotide sequence ID" value="XM_628506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY72"/>
    <dbReference type="GeneID" id="3372059"/>
    <dbReference type="KEGG" id="cpv:cgd7_3440"/>
    <dbReference type="InParanoid" id="Q5CY72"/>
    <dbReference type="OrthoDB" id="343174at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="113"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90344.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="132" mass="15264" checksum="0915B0E9CFB7DCC3" modified="2005-04-12" version="1">MNNRNFRGLNFKIENIQHDSNLILQLTELICNEPLDVKMYIETLVERINLKNIDFANLMLEKIKTTLNDALNTILINCEDLKTLEANSVILKEGSRKLFKGILRDNCYIEKDMRNLLFASIAIVAIIILLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY73</accession>
    <name>Q5CY73_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_3430</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90343.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628507.1">
        <property type="nucleotide sequence ID" value="XM_628505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY73"/>
    <dbReference type="STRING" id="353152.Q5CY73"/>
    <dbReference type="GeneID" id="3372058"/>
    <dbReference type="KEGG" id="cpv:cgd7_3430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3430"/>
    <dbReference type="InParanoid" id="Q5CY73"/>
    <dbReference type="OMA" id="LECTRAN"/>
    <dbReference type="OrthoDB" id="339325at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584:SF369">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 19-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11584">
        <property type="entry name" value="SERINE/THREONINE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="307"/>
            <end position="576"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="177"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="177"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90343.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="637" mass="72136" checksum="1E7AAE1B7416309F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYA5</accession>
    <name>Q5CYA5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3090</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628475.1">
        <property type="nucleotide sequence ID" value="XM_628473.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYA5"/>
    <dbReference type="GeneID" id="3372291"/>
    <dbReference type="KEGG" id="cpv:cgd7_3090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3090"/>
    <dbReference type="InParanoid" id="Q5CYA5"/>
    <dbReference type="OMA" id="AVENIWY"/>
    <dbReference type="OrthoDB" id="338069at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="686" mass="80250" checksum="D4B53AC62C3AC18C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYH3</accession>
    <name>Q5CYH3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large secreted protein, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_2340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628407.1">
        <property type="nucleotide sequence ID" value="XM_628405.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372207"/>
    <dbReference type="KEGG" id="cpv:cgd7_2340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2340"/>
    <dbReference type="InParanoid" id="Q5CYH3"/>
    <dbReference type="OMA" id="AKEMAIM"/>
    <dbReference type="OrthoDB" id="339854at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="41"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2223" mass="260539" checksum="104E20FB177FF671" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYH4</accession>
    <name>Q5CYH4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">SAR1-like small GTpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd7_2330</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the small GTPase superfamily. SAR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628406.1">
        <property type="nucleotide sequence ID" value="XM_628404.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYH4"/>
    <dbReference type="FunCoup" id="Q5CYH4">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYH4"/>
    <dbReference type="GeneID" id="3371968"/>
    <dbReference type="KEGG" id="cpv:cgd7_2330"/>
    <dbReference type="InParanoid" id="Q5CYH4"/>
    <dbReference type="OMA" id="GLWNKHG"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00879">
        <property type="entry name" value="Sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001150">
        <property type="entry name" value="Small GTP-binding protein sar1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006687">
        <property type="entry name" value="Small_GTPase_SAR1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45684">
        <property type="entry name" value="RE74312P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51422">
        <property type="entry name" value="SAR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 15" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 15" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="9 15" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8 15" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="45"/>
            <end position="52"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="48"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="50"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="52"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="53"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="91"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="147"/>
            <end position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="147"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="148"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="150"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="193"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="194"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606687-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU003926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK90620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="211" mass="24135" checksum="5AECC1377EA87821" modified="2005-04-12" version="1" fragment="single">LPITSRSCLCISDFKECTMFVFSWFRDILSWFGLSNKSAKILFLGLDNAGKTTLLHMLKDDRIATHVPTLHPHSEELVIGKIKFKTFDLGGHETARRIWKDYFATVDAIVFLVDASDRSRFGETREELSNLLETPELQNVPFVILGNKIDIPMAASEDELRHSLGLFEHLTYGRGEKRGDNGIRPVEVFMCSVVRRMGYSEAFRWLSQFLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYI4</accession>
    <name>Q5CYI4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_2220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628396.1">
        <property type="nucleotide sequence ID" value="XM_628394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYI4"/>
    <dbReference type="GeneID" id="3372199"/>
    <dbReference type="KEGG" id="cpv:cgd7_2220"/>
    <dbReference type="InParanoid" id="Q5CYI4"/>
    <dbReference type="OrthoDB" id="343198at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="109" mass="12736" checksum="F72ACB3D23FEF576" modified="2005-04-12" version="1">MFETAGSPFRNVRKGVNDPLNDEDMAVLDMPLGYTPDGIRDIVEEYFWGDFPIFDYERDRVNPPDYLAHFFELDSNTKNIRSILPLHRSNILEPEVSMISLLFFKTNTF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYM4</accession>
    <name>Q5CYM4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein with BRIGHT domain like HTH domain at N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_1790</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90219.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628356.1">
        <property type="nucleotide sequence ID" value="XM_628354.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYM4"/>
    <dbReference type="STRING" id="353152.Q5CYM4"/>
    <dbReference type="GeneID" id="3371739"/>
    <dbReference type="KEGG" id="cpv:cgd7_1790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1790"/>
    <dbReference type="InParanoid" id="Q5CYM4"/>
    <dbReference type="OMA" id="CELPLEC"/>
    <dbReference type="OrthoDB" id="338531at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16100">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.60">
        <property type="entry name" value="ARID DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001606">
        <property type="entry name" value="ARID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036431">
        <property type="entry name" value="ARID_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01388">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01014">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00501">
        <property type="entry name" value="BRIGHT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46774">
        <property type="entry name" value="ARID-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51011">
        <property type="entry name" value="ARID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ARID" evidence="2">
        <location>
            <begin position="1"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="129"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90219.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="914" mass="104696" checksum="5FF3E61B996D3530" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYP5</accession>
    <name>Q5CYP5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">ART-4 protein PIN+Zn ribbon domains. involved in RNA metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_1530</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the NOB1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628335.1">
        <property type="nucleotide sequence ID" value="XM_628333.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYP5"/>
    <dbReference type="FunCoup" id="Q5CYP5">
        <property type="interactions" value="437"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYP5"/>
    <dbReference type="GeneID" id="3372252"/>
    <dbReference type="KEGG" id="cpv:cgd7_1530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1530"/>
    <dbReference type="InParanoid" id="Q5CYP5"/>
    <dbReference type="OMA" id="DYAMQNT"/>
    <dbReference type="OrthoDB" id="446759at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004521">
        <property type="term" value="F:RNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd09876">
        <property type="entry name" value="PIN_Nob1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1010:FF:000020">
        <property type="entry name" value="20S-pre-rRNA D-site endonuclease NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.210.10">
        <property type="entry name" value="Nin one binding (NOB1), Zn-ribbon-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039907">
        <property type="entry name" value="NOB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017117">
        <property type="entry name" value="Nob1_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036283">
        <property type="entry name" value="NOB1_Zf-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014881">
        <property type="entry name" value="NOB1_Zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033411">
        <property type="entry name" value="Ribonuclease_PIN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12814:SF2">
        <property type="entry name" value="RNA-BINDING PROTEIN NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17146">
        <property type="entry name" value="PIN_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08772">
        <property type="entry name" value="Zn_ribbon_NOB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037125">
        <property type="entry name" value="D-site_20S_pre-rRNA_nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144206">
        <property type="entry name" value="NOB1 zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 8 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 8 9" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ribonuclease PIN" evidence="12">
        <location>
            <begin position="5"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="Nin one binding (NOB1) Zn-ribbon-like" evidence="11">
        <location>
            <begin position="249"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="131"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="381"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="10">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="259"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="262"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="274"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="277"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR037125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR037125-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08772"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF17146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK90206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="404" mass="45955" checksum="3C87574A379E9F85" modified="2005-04-12" version="1">MGRYIILDTGAILRLGKHDFMDDVLLTVPSVIREVKDKKALEKMFYLQDRIQVMEPSEQDCGFVKKFSKETGDFGFLSETDFQVIALTLSYHKKYDEISKLNSKPREISLVTKSEEVGSCEKGMDKDLQEVEMETGEQKEQSTEDEDDWETANGQSSRREEVQSGEDEEEEEECEEEECEEDEDVSKGLEDDVFSGGWITKANITSVMGGLSSGSQSHFVVACMTTDYSMQNVLLQMGLNLVEIHGLSVKTIKRWGLLCCGCYTYERDTSRKFCGKCGNATLDRVPIKVSSDGTIELDCYRKKVNLRGTIYSIPKPRRGVRNQEIILAEDQLMMGGRQRLLNHQRKKWEKACKERDPFSNSGADLESSWGKQFGSFRYPEIKIGMGRGNPNSNSWQKKRSGKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYS1</accession>
    <name>Q5CYS1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_1240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628309.1">
        <property type="nucleotide sequence ID" value="XM_628307.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYS1"/>
    <dbReference type="GeneID" id="3371854"/>
    <dbReference type="KEGG" id="cpv:cgd7_1240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1240"/>
    <dbReference type="InParanoid" id="Q5CYS1"/>
    <dbReference type="OrthoDB" id="343752at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="31"/>
            <end position="50"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="328" mass="37242" checksum="9E987D58DF12F719" modified="2005-04-12" version="1">MNIEDKSGNKLKKKINILFERLFSNDGISHIYLLLVIILLVNLGIGLFFCGRNLNKQSELISSSIFDININFPKGDKDTNNNNSVYVPRDEILNQNKPQDSKSTTTTTTTKKVSTVITASTTTTTTKVDTKNYNVQSPTDNSIPTCLYSSKFPTKYDLNGLLFWNVSSDTYIYWGYQNKTGTVYILGNNKQINSSVQLTDNISSKSDLDQPKLIEFKESNIVDSKVKIGQVASSKVIAIGERILPPYWYMNWVEQTSTRSKERFKPLFQPCLGSLYTYSNKNLQGFFQDQGVVYMCGFKSYTVEKDLIELKNTPFIKLKTNIQGKFTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYU2</accession>
    <name>Q5CYU2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">F27M3_19 plant like RRM plus AlkB domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_1000</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the alkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628288.1">
        <property type="nucleotide sequence ID" value="XM_628286.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYU2"/>
    <dbReference type="STRING" id="353152.Q5CYU2"/>
    <dbReference type="GeneID" id="3371997"/>
    <dbReference type="KEGG" id="cpv:cgd7_1000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1000"/>
    <dbReference type="InParanoid" id="Q5CYU2"/>
    <dbReference type="OMA" id="RNVNTRH"/>
    <dbReference type="OrthoDB" id="271595at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032451">
        <property type="term" value="F:demethylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070988">
        <property type="term" value="P:demethylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.590">
        <property type="entry name" value="Alpha-ketoglutarate-dependent dioxygenase AlkB-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027450">
        <property type="entry name" value="AlkB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037151">
        <property type="entry name" value="AlkB-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032857">
        <property type="entry name" value="ALKBH4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005123">
        <property type="entry name" value="Oxoglu/Fe-dep_dioxygenase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463:SF1">
        <property type="entry name" value="2-OXOGLUTARATE AND FE-DEPENDENT OXYGENASE FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12463">
        <property type="entry name" value="OXYGENASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13532">
        <property type="entry name" value="2OG-FeII_Oxy_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51197">
        <property type="entry name" value="Clavaminate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51471">
        <property type="entry name" value="FE2OG_OXY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="17"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="Fe2OG dioxygenase" evidence="4">
        <location>
            <begin position="199"/>
            <end position="320"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007879"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="350" mass="41201" checksum="01F937DEC0316674" modified="2005-04-12" version="1">MTEEIIYSYKRSKNPSELIHISNLGRKCYFGLEEDLLKEFQVFGEVKEFHLGENSNSFVLFANLPASIRFYEHCMQLHAEETPVLIGGRRIKASYSQRVEIKNVIEQKNEDYDENKRFLADKGLVLVEDFINKLEAIELLDWIDNNGQWETKLNRKVQHYGYSFDYNNKTISSVWERDIPPILNRLIERMLSLKIITEVPDQITINEYEVGKGIGPHIDSHHTIGENISVISLGSGILFEFNELSKRKNPDCSSKEGSGSRKYDRISKRTVYIPENSLYIMKNEIRYAWEHGIKSRMYDKIQGKFQQRKRRVSITIRKYIESHYNYPCECDYKDFCDSRDPSIRILPERI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYV8</accession>
    <name>Q5CYV8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Queuine tRNA-ribosyltransferase catalytic subunit 1</fullName>
            <ecNumber evidence="6">2.4.2.64</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">Guanine insertion enzyme</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="6">tRNA-guanine transglycosylase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming queuine, allowing a nucleophilic attack on the C1' of the ribose to form the product.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>guanosine(34) in tRNA + queuine = queuosine(34) in tRNA + guanine</text>
            <dbReference type="Rhea" id="RHEA:16633"/>
            <dbReference type="Rhea" id="RHEA-COMP:10341"/>
            <dbReference type="Rhea" id="RHEA-COMP:18571"/>
            <dbReference type="ChEBI" id="CHEBI:16235"/>
            <dbReference type="ChEBI" id="CHEBI:17433"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="ChEBI" id="CHEBI:194431"/>
            <dbReference type="EC" id="2.4.2.64"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="6">Heterodimer of a catalytic subunit and an accessory subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the queuine tRNA-ribosyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.64" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628272.1">
        <property type="nucleotide sequence ID" value="XM_628270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYV8"/>
    <dbReference type="FunCoup" id="Q5CYV8">
        <property type="interactions" value="165"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYV8"/>
    <dbReference type="GeneID" id="3372022"/>
    <dbReference type="KEGG" id="cpv:cgd7_830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_830"/>
    <dbReference type="InParanoid" id="Q5CYV8"/>
    <dbReference type="OMA" id="IDLFDCV"/>
    <dbReference type="OrthoDB" id="10249838at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008479">
        <property type="term" value="F:tRNA-guanosine(34) queuine transglycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.105:FF:000004">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00168">
        <property type="entry name" value="Q_tRNA_Tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004803">
        <property type="entry name" value="TGT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00430">
        <property type="entry name" value="Q_tRNA_tgt"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00449">
        <property type="entry name" value="tgt_general"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43530:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE CATALYTIC SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="1 6" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 6" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5 6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="8">
        <location>
            <begin position="42"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="RNA binding" evidence="6">
        <location>
            <begin position="279"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="120"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="6">
        <location>
            <position position="298"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="120"/>
            <end position="124"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="174"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="336"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="338"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="366"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="431" mass="48796" checksum="8F759881BA69EBB4" modified="2005-04-12" version="1">MRNEISKESNEPHHEDSMSLPPVLPIKKGEALSFYVAHSCGRARYGVLNLPHGRVDTPIFMPVATHGSIKGLSSLQVEELNVPILLGNAYHLGSRPGDEIIDKFGGLHNFMRWNRNILTDSGGFQMVSLLKFANITEEGVEFRHPYTNANLLFTPEKSIQVQNAIGADIIMQLDDVITAKSTDYQRFDEAVDRTTRWLDRCIKAHKKPDKQNLFAIVQGGIFKDLRERSLKSLKERNTPGYAIGGLSGGESKDSFWQIIELCTRSGVGLPENKPRYVMGVGYPIDILVCVALGADMFDCVYPCRTARFGTAMVHNGLLKLKLSKYKDDARPIDSRCKCYCCKHYSRAALYRIVLKDSLACQLMTIHNISFMMEFCNDMRNAIKNQTFGEYCKSFVRNYYSSTELDHLSDLEKKEGIPKWVVDAFKYIDIHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ18</accession>
    <name>Q5CZ18_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_180</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628212.1">
        <property type="nucleotide sequence ID" value="XM_628210.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ18"/>
    <dbReference type="GeneID" id="3372035"/>
    <dbReference type="KEGG" id="cpv:cgd7_180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_180"/>
    <dbReference type="InParanoid" id="Q5CZ18"/>
    <dbReference type="OMA" id="GQNIQDE"/>
    <dbReference type="OrthoDB" id="341174at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254676" description="Lipoprotein" evidence="1">
        <location>
            <begin position="22"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="146" mass="16863" checksum="5AF55789200333F3" modified="2005-04-12" version="1">MIGNMRLIFIIVGLLIGLISCEERENISIENSINETSIPNEETNLRRLYGKGQYNTVYEPVYMQKVQYVPAKSYKKVMYTVPEKSTYVVPQKQQMRYVPVGYAKGNPSPPQMYVPVTKSEPNVYVPVTYSKGMRYLEESPEELIHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPM0</accession>
    <name>A3FPM0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">HTH OST-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388366.1">
        <property type="nucleotide sequence ID" value="XM_001388329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPM0"/>
    <dbReference type="GeneID" id="3371865"/>
    <dbReference type="KEGG" id="cpv:cgd7_410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_410"/>
    <dbReference type="InParanoid" id="A3FPM0"/>
    <dbReference type="OMA" id="SHWIDPK"/>
    <dbReference type="OrthoDB" id="447390at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.610">
        <property type="entry name" value="LOTUS domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041966">
        <property type="entry name" value="LOTUS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025677">
        <property type="entry name" value="OST-HTH-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025605">
        <property type="entry name" value="OST-HTH/LOTUS_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14418">
        <property type="entry name" value="OHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51644">
        <property type="entry name" value="HTH_OST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH OST-type" evidence="1">
        <location>
            <begin position="284"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="405" mass="46654" checksum="F53C814A36905C58" modified="2007-04-03" version="1">MGIGTRTGTGTGTVVMRPGPEFWKERRLDLIKDALKSLYIDRTRPHLQELIRRLKERVDLGANYNLQMLVKDLTENEEEFLLFSNGEIYFRNLNVPDNHWIDPKNPNNPYSHEIWSGFLQYINNLVCVKGESNINGSNTINNSNNYSIDSKGHELIINQKESESDFLLIPLNSNYSNSQIEPDLLRYQFKGGRYGVAMEIHKAKISQLEDLSLGELSHLVQLAINGGILQYENNVLKPRCTCVKIAAAALSMDVDQIESNETPNDDSNCSALINRLEKKSLHNKLIDLKNELNEILILYPNGILLSLLKRFYNRYWGKKLSPTTFGYTHISTLLLSDELKKTCRLYFDSLNHVIVQSTQFNIPENVRLLEEKKFQKKTSFLNSDLFVPIRNMSDISFEYMRLLNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPN2</accession>
    <name>A3FPN2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uracil-DNA glycosylase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_1590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51571.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388378.1">
        <property type="nucleotide sequence ID" value="XM_001388341.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPN2"/>
    <dbReference type="GeneID" id="3371784"/>
    <dbReference type="KEGG" id="cpv:cgd7_1590"/>
    <dbReference type="InParanoid" id="A3FPN2"/>
    <dbReference type="OrthoDB" id="10031947at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004844">
        <property type="term" value="F:uracil DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097510">
        <property type="term" value="P:base-excision repair, AP site formation via deaminated base removal"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10027">
        <property type="entry name" value="UDG-F1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.470.10">
        <property type="entry name" value="Uracil-DNA glycosylase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002043">
        <property type="entry name" value="UDG_fam1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005122">
        <property type="entry name" value="Uracil-DNA_glycosylase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036895">
        <property type="entry name" value="Uracil-DNA_glycosylase-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11264:SF0">
        <property type="entry name" value="URACIL-DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03167">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00986">
        <property type="entry name" value="UDG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00987">
        <property type="entry name" value="UreE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52141">
        <property type="entry name" value="Uracil-DNA glycosylase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Uracil-DNA glycosylase-like" evidence="5">
        <location>
            <begin position="116"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51571.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="211" mass="23992" checksum="80F30D114281F4F9" modified="2007-04-03" version="1">MSQTSILSYLNKRSAENICKDSIECGSDLNRDSAVKNRRICVKETEIKSSKEAEEENQEYYPSESELREYFGDEWFEALKDELRKPYFVKCMKKVQERRNYAKVYPPSDKMFSCFKATPLNKISVVILGQDPYHQPGQAMGLSFSVPKGVPVPPSLRNIYKEIGKGNPGHGDLSSWAEQGVFLLNSLLSVEEGKPMSHXDLCKFDSNNYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPQ7</accession>
    <name>A3FPQ7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Coatomer subunit zeta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd7_4180</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3 12">Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="12">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 12">Golgi apparatus membrane</location>
            <topology evidence="1 12">Peripheral membrane protein</topology>
            <orientation evidence="1 12">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="12">Cytoplasmic vesicle</location>
            <location evidence="12">COPI-coated vesicle membrane</location>
            <topology evidence="12">Peripheral membrane protein</topology>
            <orientation evidence="12">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51596.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388403.1">
        <property type="nucleotide sequence ID" value="XM_001388366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPQ7"/>
    <dbReference type="FunCoup" id="A3FPQ7">
        <property type="interactions" value="155"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPQ7"/>
    <dbReference type="GeneID" id="3371805"/>
    <dbReference type="KEGG" id="cpv:cgd7_4180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4180"/>
    <dbReference type="InParanoid" id="A3FPQ7"/>
    <dbReference type="OMA" id="NELMLHS"/>
    <dbReference type="OrthoDB" id="6585768at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039652">
        <property type="entry name" value="Coatomer_zeta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043:SF0">
        <property type="entry name" value="COATOMER SUBUNIT ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11043">
        <property type="entry name" value="ZETA-COAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 12" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10 12" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6 12" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="7 12" id="KW-0653">Protein transport</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 12" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="13">
        <location>
            <begin position="10"/>
            <end position="151"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU366053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAZ51596.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="176" mass="19329" checksum="562DDA7E367853E7" modified="2007-04-03" version="1">MFDSIVGCILLDTDGNRIASRYYGNLENIGLADHAAQRQFEDQLHSKGQKLSGKTEAEALFVGEMLCLVRFAGDFSIYIVSSPSENELILFDVLNCIYNSLSIIIPGQLSKKGLFESLDTVHLIFDEVTDSSGILFETEAGAVCQRAQMQGSKALENTAFNQAFASAKENIMRGFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPS6</accession>
    <name>A3FPS6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">P-type ATPase A domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd6_720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51499.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388305.1">
        <property type="nucleotide sequence ID" value="XM_001388268.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPS6"/>
    <dbReference type="FunCoup" id="A3FPS6">
        <property type="interactions" value="482"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPS6"/>
    <dbReference type="GeneID" id="3375929"/>
    <dbReference type="KEGG" id="cpv:cgd6_720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_720"/>
    <dbReference type="InParanoid" id="A3FPS6"/>
    <dbReference type="OMA" id="QKTKYVW"/>
    <dbReference type="OrthoDB" id="48943at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019829">
        <property type="term" value="F:ATPase-coupled monoatomic cation transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015662">
        <property type="term" value="F:P-type ion transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006874">
        <property type="term" value="P:intracellular calcium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006544">
        <property type="entry name" value="P-type_TPase_V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630">
        <property type="entry name" value="CATION-TRANSPORTING ATPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45630:SF7">
        <property type="entry name" value="ENDOPLASMIC RETICULUM TRANSMEMBRANE HELIX TRANSLOCASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="241"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="871"/>
            <end position="892"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="939"/>
            <end position="959"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1017"/>
            <end position="1037"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="1057"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="13">
        <location>
            <begin position="77"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="483"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="769"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="484"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="769"/>
            <end position="784"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAZ51499.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1088" mass="123669" checksum="680632AC197A21DC" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPX2</accession>
    <name>A3FPX2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ATP-binding cassette transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_4700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51545.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388351.1">
        <property type="nucleotide sequence ID" value="XM_001388314.1"/>
    </dbReference>
    <dbReference type="SMR" id="A3FPX2"/>
    <dbReference type="FunCoup" id="A3FPX2">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPX2"/>
    <dbReference type="GeneID" id="3375976"/>
    <dbReference type="KEGG" id="cpv:cgd6_4700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4700"/>
    <dbReference type="InParanoid" id="A3FPX2"/>
    <dbReference type="OMA" id="GFGQEEQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015421">
        <property type="term" value="F:ABC-type oligopeptide transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090374">
        <property type="term" value="P:oligopeptide export from mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18577">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18578">
        <property type="entry name" value="ABC_6TM_Pgp_ABCB1_D2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000218">
        <property type="entry name" value="Multidrug ABC transporter ATP-binding protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039421">
        <property type="entry name" value="Type_1_exporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394">
        <property type="entry name" value="ATP-DEPENDENT PERMEASE MDL1, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43394:SF27">
        <property type="entry name" value="ATP-DEPENDENT TRANSLOCASE ABCB1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="59"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="104"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="205"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="283"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="328"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="736"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="782"/>
            <end position="804"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="60"/>
            <end position="359"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="392"/>
            <end position="629"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="10">
        <location>
            <begin position="740"/>
            <end position="1021"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007577"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51545.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1283" mass="144433" checksum="9A26BFFEE0254525" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPX8</accession>
    <name>A3FPX8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">GPI mannosyltransferase 2</fullName>
            <ecNumber evidence="11">2.4.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_5100</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Endoplasmic reticulum membrane</location>
            <topology evidence="1 11">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the PIGV family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.-" evidence="11"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388357.1">
        <property type="nucleotide sequence ID" value="XM_001388320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPX8"/>
    <dbReference type="FunCoup" id="A3FPX8">
        <property type="interactions" value="106"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPX8"/>
    <dbReference type="GeneID" id="3375982"/>
    <dbReference type="KEGG" id="cpv:cgd6_5100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5100"/>
    <dbReference type="InParanoid" id="A3FPX8"/>
    <dbReference type="OMA" id="GALFIWC"/>
    <dbReference type="OrthoDB" id="10252502at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031501">
        <property type="term" value="C:mannosyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000009">
        <property type="term" value="F:alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004376">
        <property type="term" value="F:GPI mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007315">
        <property type="entry name" value="PIG-V/Gpi18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12468:SF2">
        <property type="entry name" value="GPI MANNOSYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04188">
        <property type="entry name" value="Mannosyl_trans2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8 11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="4 11" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="10 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7 11 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="109"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="146"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="204"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="248"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="320"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="360"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="388"/>
            <end position="407"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU363112"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="440" mass="52130" checksum="AA035B1AA20C0033" modified="2007-04-03" version="1">MKTTIGRVIFLAICSRLLCIFISFLTNDLFSTIRNTGILHLYLDNNQNSQNTVTWKLFKSFINWDGEYYLRISYYNDYEYEHQHAFLPLYPILVNQISKIVSGINKTSILVNMIVGTIISNLAFVLASVGLYLFQCELFYKMKIKNVVFPGISTLFFLFPSSNIFNSSMYTESLYSCFNFWGAFLILKAESNSHKFGFFSIKNFIYLILSVLCMSVTCGIRSNGILNSIPLFFYFVSTSPSIKNILKFILHWSIAFIMFISTIFPFLAYLIYSYFRYCVYISESRPWCKSLIPNIYSFVQDEYWSNGIFNYWRIEKFDKFILIIPFILVTIYSIKIFFIKRSKKDKNNVFSIIYQILDHFQHCYSVFGYFFQIYFLLISILLYGYVEVIIRLFNCIPLYFTLMGYFFQNQNPKLSNLLLIYQIFTFIFGSIWFPNFLPWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPZ8</accession>
    <name>A3FPZ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_3960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat SWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51479.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388439.1">
        <property type="nucleotide sequence ID" value="XM_001388402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPZ8"/>
    <dbReference type="FunCoup" id="A3FPZ8">
        <property type="interactions" value="404"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPZ8"/>
    <dbReference type="GeneID" id="3374658"/>
    <dbReference type="KEGG" id="cpv:cgd8_3960"/>
    <dbReference type="InParanoid" id="A3FPZ8"/>
    <dbReference type="OMA" id="HNEGYIR"/>
    <dbReference type="OrthoDB" id="27537at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016070">
        <property type="term" value="P:RNA metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037867">
        <property type="entry name" value="Swd2/WDR82"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 82"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19861">
        <property type="entry name" value="WD40 REPEAT PROTEIN SWD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005616"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51479.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="316" mass="35647" checksum="DCEE4259A0312C1F" modified="2007-04-03" version="1">MLEQSRTVLNDDLITKFKACRVFKDAITPISNMDWSEDGDSLLICESDTLRVYTISSGDIFRIHHSRKNSMDAIKFAHSNKQCLVASNKTDGDATIRLWDIQENRYIRATKLSSGPYNGISVHPNKDLFIVSTNDSKVSIYNFKLETPLAVQSTKNKTPISAFDPEGRTFAVATDDHIITMYDSKTYSPFDTFNLSSHIGKKNYIDHITFSPDGRLILVKTNLGKIFTISSFRGELFQEYKTVNKSPKSETRPVFSSDSQYVIHGLQDSTISIWSTTTAKHIVNLTGHVGQPKCIAFNPKKAFFASGMFINHLKYM</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ78</accession>
    <name>A3FQ78_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RAB6 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_1940</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388214.1">
        <property type="nucleotide sequence ID" value="XM_001388177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ78"/>
    <dbReference type="FunCoup" id="A3FQ78">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ78"/>
    <dbReference type="GeneID" id="3373442"/>
    <dbReference type="KEGG" id="cpv:cgd2_1940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1940"/>
    <dbReference type="InParanoid" id="A3FQ78"/>
    <dbReference type="OMA" id="PVSNDGC"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01861">
        <property type="entry name" value="Rab6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000229">
        <property type="entry name" value="Probable Ras-related protein Rab-6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050227">
        <property type="entry name" value="Rab"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47977">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="6" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0636">Prenylation</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="219" mass="25185" checksum="40EBF7AA3F3AAF50" modified="2007-04-03" version="1">MADNSSRNQISKFKFVFLGEQSVGKTSIITRFMYDTFDNNYQATIGIDFLSKTLYLEDRTIRLQLWDTAGQERFRSLIPSYIRDSSVAVVVYDITNRSTFLNTTKWIEDVRNERGKDVIISLIGNKADLEDRRQVKYEEAEKLAQENNIMFIETSAKNGYNIKSLFKKLASTLPNLDYIQEGKNEANSSSSLENNNANKIVDLQSGEENSRFNYKKCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ89</accession>
    <name>A3FQ89_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Coenzyme Q3, methyltransferase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_2830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51398.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388225.1">
        <property type="nucleotide sequence ID" value="XM_001388188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ89"/>
    <dbReference type="FunCoup" id="A3FQ89">
        <property type="interactions" value="25"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ89"/>
    <dbReference type="GeneID" id="3373547"/>
    <dbReference type="KEGG" id="cpv:cgd2_2830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2830"/>
    <dbReference type="InParanoid" id="A3FQ89"/>
    <dbReference type="OMA" id="HWEKMIS"/>
    <dbReference type="OrthoDB" id="3265906at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061542">
        <property type="term" value="F:3-demethylubiquinol 3-O-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010420">
        <property type="term" value="F:polyprenyldihydroxybenzoate methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010233">
        <property type="entry name" value="UbiG_MeTrfase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01983">
        <property type="entry name" value="UbiG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43464:SF19">
        <property type="entry name" value="UBIQUINONE BIOSYNTHESIS O-METHYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0831">Ubiquinone biosynthesis</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51398.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="306" mass="35169" checksum="4533DC20311001DD" modified="2007-04-03" version="1">MFRNFSFKKSLFSSCYSTLENNRFFGIDFRNYLRILQKNKIYGSYKFSTIDAKQINNFDAYSSYSWFPETHDSILLKFNHLRTSFLLEHISNKSASLNGPLSGKKILDIGSGAGIFSERLSELGGDVLGVDASYKSIDIAYKNALCNSTSFKEISKFNNENELNNFMNSMPKPRSLRYFKGGIEHIQKSEIFDIIVASEVIEHVNNPGIFVKLISKFQYLRFIISVTRSGNLLKKDGIVLFTTLNRTVLCYIYSIIFGEKIFEMIPKVSSIDYFESIHEHRGHIAGESLLNRMNLMVLQEKMAYIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQH2</accession>
    <name>A3FQH2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Serine-threonine kinase receptor-associated protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the WD repeat STRAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388256.1">
        <property type="nucleotide sequence ID" value="XM_001388219.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQH2"/>
    <dbReference type="FunCoup" id="A3FQH2">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQH2"/>
    <dbReference type="GeneID" id="3373370"/>
    <dbReference type="KEGG" id="cpv:cgd5_680"/>
    <dbReference type="InParanoid" id="A3FQH2"/>
    <dbReference type="OMA" id="RRWMADE"/>
    <dbReference type="OrthoDB" id="24966at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002183">
        <property type="term" value="P:cytoplasmic translational initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19877:SF1">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="72"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="115"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="219"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00038394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040390"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="261" mass="29631" checksum="398D492FBE803162" modified="2007-04-03" version="1">MSSADQKCVSFDIERAEIISSYPMSGTCRFVEFNRKYDNQDKFVVAVDQFYPEPRQLLIKKVGDPNMEGVRITGINSRITRAHWGMFDQNIISGHEDGGIYIWDIRQSSEPYEVLRAHSKLLTCCSFSEDRTLMLTCSHDMTAKLWDMVNLKEIRKYTTNRLLNGCSISPNFNKEKDPKRHILLGGGQLAQDVTTTGTQEGKFQTLIMHMIYGTELGAIKGHFGTMNALVYAPDGMSFTTGGEDGFVRINHFDDEYLKLDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQN5</accession>
    <name>A3FQN5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_730</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAZ51241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388053.1">
        <property type="nucleotide sequence ID" value="XM_001388016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQN5"/>
    <dbReference type="GeneID" id="3372627"/>
    <dbReference type="KEGG" id="cpv:cgd4_730"/>
    <dbReference type="InParanoid" id="A3FQN5"/>
    <dbReference type="OMA" id="TELEHCK"/>
    <dbReference type="OrthoDB" id="342474at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="232"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="8"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="95"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="232"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="245"/>
            <end position="256"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="341" mass="39739" checksum="C46EF47E57AD36FC" modified="2007-04-03" version="1">MRELYKVDKEIKDELEEKVNENNNISAEISKLKENNETNEKKKVSIEEEIVKLENDLILKADEIKLSKEDLLRISDELDKKKLETSKFIQELVENKRCLDEINELNILLESKREKLRQMDAKSESSNSYYNIIELEHINEANNLLEHEILSLNSKIKQDEKVLIDEISKLKESKVLVSAEDIEKSLTELEMELAEDKLDKISLIENFDQDETKMDDILNQISKIRQLLNEQENDNNNNEEEISIKKRKGKLKRSKAKNTQSMEHVLIQSLRMIQKIDQFRVGSINQSSDIKETQKINNIITTENDNNRIVKPLESPKSGVSGLGRRVMISNRRLLTPRKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQP6</accession>
    <name>A3FQP6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">arginine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.19</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Arginyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">cgd5_4400</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Arg) + L-arginine + ATP = L-arginyl-tRNA(Arg) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20301"/>
            <dbReference type="Rhea" id="RHEA-COMP:9658"/>
            <dbReference type="Rhea" id="RHEA-COMP:9673"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32682"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78513"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.19"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.19" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAZ51231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388293.1">
        <property type="nucleotide sequence ID" value="XM_001388256.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQP6"/>
    <dbReference type="FunCoup" id="A3FQP6">
        <property type="interactions" value="409"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQP6"/>
    <dbReference type="GeneID" id="3372533"/>
    <dbReference type="KEGG" id="cpv:cgd5_4400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4400"/>
    <dbReference type="InParanoid" id="A3FQP6"/>
    <dbReference type="OMA" id="NKPLHLG"/>
    <dbReference type="OrthoDB" id="68056at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004814">
        <property type="term" value="F:arginine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006420">
        <property type="term" value="P:arginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00671">
        <property type="entry name" value="ArgRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000116">
        <property type="entry name" value="Arginine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.730.10:FF:000006">
        <property type="entry name" value="Arginyl-tRNA synthetase 2, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.70">
        <property type="entry name" value="Arginyl tRNA synthetase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.730.10">
        <property type="entry name" value="Isoleucyl-tRNA Synthetase, Domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00123">
        <property type="entry name" value="Arg_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001412">
        <property type="entry name" value="aa-tRNA-synth_I_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001278">
        <property type="entry name" value="Arg-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005148">
        <property type="entry name" value="Arg-tRNA-synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036695">
        <property type="entry name" value="Arg-tRNA-synth_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035684">
        <property type="entry name" value="ArgRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008909">
        <property type="entry name" value="DALR_anticod-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009080">
        <property type="entry name" value="tRNAsynth_Ia_anticodon-bd"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00456">
        <property type="entry name" value="argS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956:SF5">
        <property type="entry name" value="ARGININE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11956">
        <property type="entry name" value="ARGINYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03485">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05746">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00750">
        <property type="entry name" value="tRNA-synt_1d"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01038">
        <property type="entry name" value="TRNASYNTHARG"/>
    </dbReference>
    <dbReference type="SMART" id="SM01016">
        <property type="entry name" value="Arg_tRNA_synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00836">
        <property type="entry name" value="DALR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47323">
        <property type="entry name" value="Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55190">
        <property type="entry name" value="Arginyl-tRNA synthetase (ArgRS), N-terminal 'additional' domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00178">
        <property type="entry name" value="AA_TRNA_LIGASE_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Arginyl tRNA synthetase N-terminal" evidence="16">
        <location>
            <begin position="6"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="domain" description="DALR anticodon binding" evidence="15">
        <location>
            <begin position="491"/>
            <end position="616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="417"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="417"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00049339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363038"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00836"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAZ51231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="616" mass="70956" checksum="D6B06B2F37E83616" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPS9</accession>
    <name>Q5CPS9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_4190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625435.1">
        <property type="nucleotide sequence ID" value="XM_625435.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372401"/>
    <dbReference type="KEGG" id="cpv:cgd4_4190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4190"/>
    <dbReference type="InParanoid" id="Q5CPS9"/>
    <dbReference type="OrthoDB" id="10631660at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="123" mass="14830" checksum="7C5E3C081BD38741" modified="2005-04-12" version="1">MIIFAIILLLIKIMRYYNWVPLKSLKLELKKRFRTNSKIFIIDISSDEDSDISQDKEKKRKRRVKSRKIYDSQEISYTPRSEYLSNKSYTLSQRFNTNNSETXKKLEIHLQIVQVQKNLNYPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPT4</accession>
    <name>Q5CPT4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Metacaspase-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_4120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C14B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87431.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625430.1">
        <property type="nucleotide sequence ID" value="XM_625430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPT4"/>
    <dbReference type="STRING" id="353152.Q5CPT4"/>
    <dbReference type="GeneID" id="3372405"/>
    <dbReference type="KEGG" id="cpv:cgd4_4120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4120"/>
    <dbReference type="InParanoid" id="Q5CPT4"/>
    <dbReference type="OrthoDB" id="343892at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12660">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050452">
        <property type="entry name" value="Metacaspase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011600">
        <property type="entry name" value="Pept_C14_caspase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104:SF30">
        <property type="entry name" value="METACASPASE-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48104">
        <property type="entry name" value="METACASPASE-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00656">
        <property type="entry name" value="Peptidase_C14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C14 caspase" evidence="3">
        <location>
            <begin position="7"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="499"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="786"/>
            <end position="813"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="499"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="515"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="813"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87431.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="932" mass="104196" checksum="DBE726541BF9A273" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="Swiss-Prot" created="2014-09-03" modified="2025-02-05" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPU3</accession>
    <name>SSAT_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Diamine acetyltransferase</fullName>
            <ecNumber evidence="4">2.3.1.57</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Spermidine/spermine N(1)-acetyltransferase</fullName>
            <shortName evidence="5">CpSSAT</shortName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="primary">SSAT</name>
        <name type="ORF">cgd4_4000</name>
    </gene>
    <organism>
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain>Iowa II</strain>
        </source>
    </reference>
    <reference evidence="6" key="2">
        <citation type="journal article" date="2007" name="Mol. Biochem. Parasitol." volume="152" first="170" last="180">
            <title>Cryptosporidium parvum spermidine/spermine N1-acetyltransferase exhibits different characteristics from the host enzyme.</title>
            <authorList>
                <person name="Yarlett N."/>
                <person name="Wu G."/>
                <person name="Waters W.R."/>
                <person name="Harp J.A."/>
                <person name="Wannemuehler M.J."/>
                <person name="Morada M."/>
                <person name="Athanasopoulos D."/>
                <person name="Martinez M.P."/>
                <person name="Upton S.J."/>
                <person name="Marton L.J."/>
                <person name="Frydman B.J."/>
            </authorList>
            <dbReference type="PubMed" id="17289169"/>
            <dbReference type="DOI" id="10.1016/j.molbiopara.2007.01.004"/>
        </citation>
        <scope>FUNCTION</scope>
        <scope>CATALYTIC ACTIVITY</scope>
        <scope>BIOPHYSICOCHEMICAL PROPERTIES</scope>
        <scope>SUBUNIT</scope>
        <scope>SUBCELLULAR LOCATION</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4 5">Enzyme which catalyzes the acetylation of polyamines. Displays higher substrate specificity for spermine than for spermidine. May function to acetylate host-derived polyamines, thus alleviating the necessity for de novo synthesis of these molecules.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>an alkane-alpha,omega-diamine + acetyl-CoA = an N-acetylalkane-alpha,omega-diamine + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11116"/>
            <dbReference type="Rhea" id="RHEA-COMP:9766"/>
            <dbReference type="Rhea" id="RHEA-COMP:9767"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:70977"/>
            <dbReference type="ChEBI" id="CHEBI:70988"/>
            <dbReference type="EC" id="2.3.1.57"/>
        </reaction>
    </comment>
    <comment type="biophysicochemical properties">
        <kinetics>
            <KM evidence="4">11 uM for spermine</KM>
            <KM evidence="4">50 uM for spermidine</KM>
            <Vmax evidence="4">79.0 umol/min/mg enzyme toward spermine</Vmax>
        </kinetics>
    </comment>
    <comment type="pathway">
        <text evidence="7">Amine and polyamine degradation; putrescine degradation; N-acetylputrescine from putrescine: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homotetramer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the acetyltransferase family.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.57" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625421.1">
        <property type="nucleotide sequence ID" value="XM_625421.1"/>
    </dbReference>
    <dbReference type="PDB" id="6YUG">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.95 A"/>
        <property type="chains" value="A/B=1-152"/>
    </dbReference>
    <dbReference type="PDBsum" id="6YUG"/>
    <dbReference type="AlphaFoldDB" id="Q5CPU3"/>
    <dbReference type="SMR" id="Q5CPU3"/>
    <dbReference type="STRING" id="353152.Q5CPU3"/>
    <dbReference type="EnsemblProtists" id="EAK87438">
        <property type="protein sequence ID" value="EAK87438"/>
        <property type="gene ID" value="cgd4_4000"/>
    </dbReference>
    <dbReference type="GeneID" id="3372423"/>
    <dbReference type="KEGG" id="cpv:cgd4_4000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4000"/>
    <dbReference type="InParanoid" id="Q5CPU3"/>
    <dbReference type="OMA" id="CACAGEQ"/>
    <dbReference type="OrthoDB" id="10039976at2759"/>
    <dbReference type="BRENDA" id="2.3.1.4">
        <property type="organism ID" value="1728"/>
    </dbReference>
    <dbReference type="SABIO-RK" id="Q5CPU3"/>
    <dbReference type="UniPathway" id="UPA00188">
        <property type="reaction ID" value="UER00363"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004145">
        <property type="term" value="F:diamine N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009447">
        <property type="term" value="P:putrescine catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032918">
        <property type="term" value="P:spermidine acetylation"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032919">
        <property type="term" value="P:spermine acetylation"/>
        <property type="evidence" value="ECO:0000314"/>
        <property type="project" value="UniProtKB"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050680">
        <property type="entry name" value="YpeA/RimI_acetyltransf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43420">
        <property type="entry name" value="ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword id="KW-0002">3D-structure</keyword>
    <keyword id="KW-0012">Acyltransferase</keyword>
    <keyword id="KW-0963">Cytoplasm</keyword>
    <keyword id="KW-1185">Reference proteome</keyword>
    <keyword id="KW-0808">Transferase</keyword>
    <feature type="chain" id="PRO_0000430034" description="Diamine acetyltransferase">
        <location>
            <begin position="1"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="3">
        <location>
            <begin position="5"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="1">
        <location>
            <position position="127"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="5"/>
            <end position="9"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="12"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="15"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="turn" evidence="8">
        <location>
            <begin position="23"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="34"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="46"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="71"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="76"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="86"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="90"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="112"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="helix" evidence="8">
        <location>
            <begin position="121"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="turn" evidence="8">
        <location>
            <begin position="129"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="strand" evidence="8">
        <location>
            <begin position="139"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000250" key="1">
        <source>
            <dbReference type="UniProtKB" id="P0A951"/>
        </source>
    </evidence>
    <evidence type="ECO:0000255" key="2"/>
    <evidence type="ECO:0000255" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000269" key="4">
        <source>
            <dbReference type="PubMed" id="17289169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000303" key="5">
        <source>
            <dbReference type="PubMed" id="17289169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000305" key="6"/>
    <evidence type="ECO:0000305" key="7">
        <source>
            <dbReference type="PubMed" id="17289169"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="6YUG"/>
        </source>
    </evidence>
    <sequence length="152" mass="17837" checksum="93DC5867C9B654B2" modified="2005-04-12" version="1">MISSFEVRKATIDDYFELRNLICDVTRCTETLSREQAEERFRYNTYHPYCLVDTENGRIVGYAGFYIIPHLGRKNDSRIEHVIISKEYRNRGLGRLLCKQIIEDAKNKFNCGRIDLTVESHIAKKLYSSLEFEKVNTEVMRNSFLDLTPKSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPU7</accession>
    <name>Q5CPU7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87437.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625417.1">
        <property type="nucleotide sequence ID" value="XM_625417.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPU7"/>
    <dbReference type="GeneID" id="3372422"/>
    <dbReference type="KEGG" id="cpv:cgd4_3960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3960"/>
    <dbReference type="InParanoid" id="Q5CPU7"/>
    <dbReference type="OMA" id="CIHYQND"/>
    <dbReference type="OrthoDB" id="344113at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87437.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="157" mass="18891" checksum="A66374639DF898F4" modified="2005-04-12" version="1">MDKLEMSNECKSCESYKNEINKLRKEIYNISKSNINSQRLLEEKYTIQVQQFQEENYKLKKTVQEYEEYKHKSEIYYEEVNNTLIVAKSKLKELHERITFLEKSNSELEYKYNEAKSLLSILVEHNNYNSEFSSNKIPIKENRSNYIYQIDSNSISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPV8</accession>
    <name>Q5CPV8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_620</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87500.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625521.1">
        <property type="nucleotide sequence ID" value="XM_625521.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPV8"/>
    <dbReference type="GeneID" id="3372462"/>
    <dbReference type="KEGG" id="cpv:cgd8_620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_620"/>
    <dbReference type="InParanoid" id="Q5CPV8"/>
    <dbReference type="OrthoDB" id="342068at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87500.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="260" mass="30718" checksum="799805739979DD72" modified="2005-04-12" version="1">MRYSEIEARGFLKGILSRKSSWRIRTILFFIIFKSMESYGKGDLVTQNIGNNEAKMGIKYLQENQNIRDLNNYNLTMLIKEEEDGGSNIYRNSSQKFLDTIGNIGLLGLGNKTFNNTFQLVTPLIPNPKYNFNYENIFNNTDYNNNTVSYQPLNSRRMAEYELIHRDQVVFRPVGYHQFDVIPQVIHQIPQNQYPMFRSGYLGYPYNPINYYRSPYITTVKKNRTRILSEDIDYNIKNGYKVEYEIMELLNENNNSIFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPY2</accession>
    <name>Q5CPY2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">asparagine--tRNA ligase</fullName>
            <ecNumber evidence="2">6.1.1.22</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.22" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87485.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625497.1">
        <property type="nucleotide sequence ID" value="XM_625497.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPY2"/>
    <dbReference type="FunCoup" id="Q5CPY2">
        <property type="interactions" value="161"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPY2"/>
    <dbReference type="GeneID" id="3372447"/>
    <dbReference type="KEGG" id="cpv:cgd8_350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_350"/>
    <dbReference type="InParanoid" id="Q5CPY2"/>
    <dbReference type="OMA" id="PEMAFYD"/>
    <dbReference type="OrthoDB" id="1931232at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004816">
        <property type="term" value="F:asparagine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006421">
        <property type="term" value="P:asparaginyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04318">
        <property type="entry name" value="EcAsnRS_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000016">
        <property type="entry name" value="Asparagine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00534">
        <property type="entry name" value="Asn_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004522">
        <property type="entry name" value="Asn-tRNA-ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00457">
        <property type="entry name" value="asnS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003037">
        <property type="entry name" value="PRK03932.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594:SF34">
        <property type="entry name" value="ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22594">
        <property type="entry name" value="ASPARTYL/LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="8">
        <location>
            <begin position="159"/>
            <end position="489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87485.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="499" mass="56203" checksum="8AA8D49D4852F3A0" modified="2005-04-12" version="1">MIKPEKKFVTEYSVTGRLRIASILDGEDGGVSYIGKKVTVGGWARTVRKQCSDTLLFISLNDGSTSSNLQCVVEKTVKGFEEGLKATAGCSFKITGTIVKSPAQGQSVELLLNTGDDELKICGLCDASKYPLAKKHHSKEFLREVAHLRPRSQFFSSVMRIRNSLAIAIHEYFQKNGFMYIHTPIITAADCEGAGEMFQVTTVLPPESKNNISNIPASKIEGSQDMAVDYKKDFFGKASYLTVSGQLALENFACSMSDVYTFGPTFRAENSHTTRHLAEFWMIEPEMAFADLSDNMKLGEGLLKYTVEYVLINNMPDLLYLDKNIENGLVERLKVICKEEFARISYTEAIEMLKPHDKEFTVPVSWGMDLGSEHEKYITDVLEKRPCIIYNYPKDIKSFYMKLNEDGNTVAAMDILVPKIGEVIGGSQREDDIEKLENAIKSRNMDPAPYWWYNELRKYGSVPHSGFGLGFERLIMMVTGVENVRDVIPFPRYPNHCEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ35</accession>
    <name>Q5CQ35_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Swi/SNf2 RAD26</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_4290</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87577.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625591.1">
        <property type="nucleotide sequence ID" value="XM_625591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ35"/>
    <dbReference type="STRING" id="353152.Q5CQ35"/>
    <dbReference type="GeneID" id="3372576"/>
    <dbReference type="KEGG" id="cpv:cgd5_4290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4290"/>
    <dbReference type="InParanoid" id="Q5CQ35"/>
    <dbReference type="OMA" id="ANHEDEK"/>
    <dbReference type="OrthoDB" id="413460at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008094">
        <property type="term" value="F:ATP-dependent activity, acting on DNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006283">
        <property type="term" value="P:transcription-coupled nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050496">
        <property type="entry name" value="SNF2_RAD54_helicase_repair"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629:SF7">
        <property type="entry name" value="DNA EXCISION REPAIR PROTEIN ERCC-6-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45629">
        <property type="entry name" value="SNF2/RAD54 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="3">
        <location>
            <begin position="286"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="4">
        <location>
            <begin position="722"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="139"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="14"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="139"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="163"/>
            <end position="187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87577.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1181" mass="135576" checksum="A3D902958418E08A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ78</accession>
    <name>Q5CQ78_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">BSD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87535.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625548.1">
        <property type="nucleotide sequence ID" value="XM_625548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ78"/>
    <dbReference type="GeneID" id="3372593"/>
    <dbReference type="KEGG" id="cpv:cgd5_3840"/>
    <dbReference type="InParanoid" id="Q5CQ78"/>
    <dbReference type="OMA" id="KFPWNEI"/>
    <dbReference type="OrthoDB" id="47923at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3970.10">
        <property type="entry name" value="BSD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005607">
        <property type="entry name" value="BSD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035925">
        <property type="entry name" value="BSD_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03909">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140383">
        <property type="entry name" value="BSD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50858">
        <property type="entry name" value="BSD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BSD" evidence="1">
        <location>
            <begin position="54"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87535.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="129" mass="15319" checksum="AC7602B34173EB42" modified="2005-04-12" version="1">MQDNVFPWFHIVQWSSEELPTNTVLKWNYKSIKEKVQSLTLNKQVFLTNCPVSRIQGFSLDEDDPDCIIPFAEWAAALLSQMDELNNIRYELVPSRMSESIFWQSYFNAIRNIIIKDVSFFFFFLNRSH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ88</accession>
    <name>Q5CQ88_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein having a possible transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_3730</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625538.1">
        <property type="nucleotide sequence ID" value="XM_625538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ88"/>
    <dbReference type="STRING" id="353152.Q5CQ88"/>
    <dbReference type="GeneID" id="3372545"/>
    <dbReference type="KEGG" id="cpv:cgd5_3730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3730"/>
    <dbReference type="InParanoid" id="Q5CQ88"/>
    <dbReference type="OMA" id="NDARMTY"/>
    <dbReference type="OrthoDB" id="408027at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051059">
        <property type="term" value="F:NF-kappaB binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071356">
        <property type="term" value="P:cellular response to tumor necrosis factor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051070">
        <property type="entry name" value="NF-kappa-B_inhibitor"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46680:SF2">
        <property type="entry name" value="NF-KAPPA-B INHIBITOR ZETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="418"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="119"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="153"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="228"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="471" mass="54393" checksum="69EEA7232C0783B4" modified="2005-04-12" version="1">MLDKCIKYISKSNIDDLKELLGFDDNVSDENDDYLIISNLEDINKKSKKGVIPIHLACKIQDFDILRLLLRCEDLDVNIRDPTNSFTPIITLINNGGDIECLNLLLKRSPNLDLCDEEFGDSPLHWAVRLELPKVVHRLVKSGMDVNLLNHKTGQTPLHLAVLIGNEEVIMELIGLSANPIISDDNDLERNSILHLCILGNIPNIALYIFNSATEYQKDIMRKSVNRNGNTALHLAYMYGMMGLAEFLINNGFDKDALNDQNLSPLDLKLEYQENNRKESKEDNKISQNQYKKTEIRQRRANKIREEIYETPVSEFLVKYNIAEKPNLIINNDEEENNDKVLGKHDFVFKLFYKKGYYYLDSSFTSLTFNDLTNIGIKDKSLKELILESLSQEEKINQEKIQKSLKQQQQDKKKRNTGYSLIAISTCIFIFFILYIVLNALSRNKEIQTNPSKKPRNYSSSYTKYKARYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ97</accession>
    <name>Q5CQ97_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Iowa type II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625529.1">
        <property type="nucleotide sequence ID" value="XM_625529.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ97"/>
    <dbReference type="GeneID" id="3372536"/>
    <dbReference type="KEGG" id="cpv:cgd5_3620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3620"/>
    <dbReference type="InParanoid" id="Q5CQ97"/>
    <dbReference type="OMA" id="SENANIW"/>
    <dbReference type="OrthoDB" id="340777at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="54"/>
            <end position="90"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="950" mass="109396" checksum="B8019F4CFB147D7F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQD7</accession>
    <name>Q5CQD7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_1140</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87629.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625711.1">
        <property type="nucleotide sequence ID" value="XM_625711.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQD7"/>
    <dbReference type="GeneID" id="3372672"/>
    <dbReference type="KEGG" id="cpv:cgd4_1140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1140"/>
    <dbReference type="InParanoid" id="Q5CQD7"/>
    <dbReference type="OMA" id="HIKSEGA"/>
    <dbReference type="OrthoDB" id="341300at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.15.10">
        <property type="entry name" value="Ribonuclease Z/Hydroxyacylglutathione hydrolase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036866">
        <property type="entry name" value="RibonucZ/Hydroxyglut_hydro"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663:SF6">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42663">
        <property type="entry name" value="HYDROLASE C777.06C-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87629.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="309" mass="35245" checksum="71A173070D78BBA2" modified="2005-04-12" version="1">MHAHSHKPTRDMSSFILFLGSGTEQGTPNLEHVFKNIDNVNKGNDPFCGICQESIKMKNKNVRNPFSILIKNPVSNLNSSESERHDTFLFEIGSTFRISMLEYAIPANINRLDAIFCMGSDESSFNGIDETREVQKYERPVGNDGIVFYEPKIRVPIYFTSSALNKFNDWYSYIINYSLKDDLKSKTKVGCVQLNILDPRNSPDVTKIDSISKFNDYISLNNDIEISDEIDKNLTLNPVIIQYSNEIKITSLFFIDSDNKLSSGYCIEYASDKKLICIIPRYSIIPKETLAFLKTIQLINILIFPNCPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQF7</accession>
    <name>Q5CQF7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">WD repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_900</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87648.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625691.1">
        <property type="nucleotide sequence ID" value="XM_625691.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQF7"/>
    <dbReference type="STRING" id="353152.Q5CQF7"/>
    <dbReference type="GeneID" id="3372693"/>
    <dbReference type="KEGG" id="cpv:cgd4_900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_900"/>
    <dbReference type="InParanoid" id="Q5CQF7"/>
    <dbReference type="OMA" id="PYVQRHF"/>
    <dbReference type="OrthoDB" id="674604at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030686">
        <property type="term" value="C:90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034511">
        <property type="term" value="F:U3 snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000480">
        <property type="term" value="P:endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000472">
        <property type="term" value="P:endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013934">
        <property type="entry name" value="Utp13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19854:SF15">
        <property type="entry name" value="TRANSDUCIN BETA-LIKE PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08625">
        <property type="entry name" value="Utp13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="131"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="528"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="570"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="635"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="677"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="719"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 13 C-terminal" evidence="7">
        <location>
            <begin position="848"/>
            <end position="1001"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="276"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="467"/>
            <end position="490"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08625"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87648.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1042" mass="117785" checksum="2BCE49CDBCD09123" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQG2</accession>
    <name>Q5CQG2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Putative 60S ribosomal protein L24</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_840</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL24 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87654.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625686.1">
        <property type="nucleotide sequence ID" value="XM_625686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQG2"/>
    <dbReference type="FunCoup" id="Q5CQG2">
        <property type="interactions" value="383"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQG2"/>
    <dbReference type="GeneID" id="3372699"/>
    <dbReference type="KEGG" id="cpv:cgd4_840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_840"/>
    <dbReference type="InParanoid" id="Q5CQG2"/>
    <dbReference type="OMA" id="PGHGKKM"/>
    <dbReference type="OrthoDB" id="1727108at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00472">
        <property type="entry name" value="Ribosomal_L24e_L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.170.20:FF:000003">
        <property type="entry name" value="60S ribosomal protein L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.1270">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.170.20">
        <property type="entry name" value="Ribosomal protein L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038630">
        <property type="entry name" value="L24e/L24_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056366">
        <property type="entry name" value="Ribosomal_eL24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000988">
        <property type="entry name" value="Ribosomal_eL24-rel_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10792:SF1">
        <property type="entry name" value="RIBOSOMAL PROTEIN L24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01246">
        <property type="entry name" value="Ribosomal_L24e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57716">
        <property type="entry name" value="Glucocorticoid receptor-like (DNA-binding domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein eL24-related N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="97"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="123"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005647"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01246"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87654.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="133" mass="15279" checksum="17DC47C5FA94D333" modified="2005-04-12" version="1">MSTVKTTIKTDLCSYSEYRIYPGRGRKFVARDGRVSTFLNQKCASLFHQKIRPVKLKWSVGWRRMNKKLTNQGATSKRRNKKTVRLHKAIEGLSLDDIKQKRAQNQSNSGAAQKAALSEAKARQQKKKQSNRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQK6</accession>
    <name>Q5CQK6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">TLC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625642.1">
        <property type="nucleotide sequence ID" value="XM_625642.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQK6"/>
    <dbReference type="STRING" id="353152.Q5CQK6"/>
    <dbReference type="GeneID" id="3372733"/>
    <dbReference type="KEGG" id="cpv:cgd4_350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_350"/>
    <dbReference type="InParanoid" id="Q5CQK6"/>
    <dbReference type="OMA" id="QISWILT"/>
    <dbReference type="OrthoDB" id="341353at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="55"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="150"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="281" mass="34328" checksum="FE755857A9D8D26D" modified="2005-04-12" version="1">MESSLTRILIALAFPFTQEFWKVHGVSFTLSSTFIVLLWYYLVNKHNTDQNKMRCVFQYISSAIISFICWPVVIDLWFKYFQFEMDMLKWLQYDSYGYYKFMLNLFLSSLLFDLIFGVLYFRKQMFILNGWIHHTAYIILTLYIMRWKSYNILLVALPEEIPTYFISIYVIFPHNNRKFSQKMFFITFFIFRISYHIIGYSLLFLRASNREATQLWIPTSLTIFAHCYWYLLWLRKHWRSLFHSEEIPYSKENISTAKSNPDKEYNCIDYFDHYSNIEREI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQQ4</accession>
    <name>Q5CQQ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative 2 TPR domains at N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_3720</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625948.1">
        <property type="nucleotide sequence ID" value="XM_625948.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQQ4"/>
    <dbReference type="GeneID" id="3372935"/>
    <dbReference type="KEGG" id="cpv:cgd4_3720"/>
    <dbReference type="InParanoid" id="Q5CQQ4"/>
    <dbReference type="OMA" id="CEKKADH"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.160.11">
        <property type="entry name" value="Hnrnp arginine n-methyltransferase1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1317" mass="150771" checksum="7A7CFE9CFAB8E98C" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQS5</accession>
    <name>Q5CQS5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_3510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625927.1">
        <property type="nucleotide sequence ID" value="XM_625927.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQS5"/>
    <dbReference type="GeneID" id="3372859"/>
    <dbReference type="KEGG" id="cpv:cgd4_3510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3510"/>
    <dbReference type="InParanoid" id="Q5CQS5"/>
    <dbReference type="OrthoDB" id="338633at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="207" mass="24160" checksum="C7A5A8CF1A1C0681" modified="2005-04-12" version="1">MSSKKELPILSYCYGQVQLAYPFLPLPIILLKEEDTFLIQLCAKKFPDYKGIPYKFPIIPQDQKISFNNTLFETNYLKLENKSSKIIYKVNEKQSNIIECVINRLFDGKIFQVLEYSIIGIIACKLKMKDQKIQIERKVIRAFCSGSSSFQSGNNTDFIYGVFKVNKKFPFNWIECISNPEDLLEKKLMNPDQAIKDALYEMDEEEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQX0</accession>
    <name>Q5CQX0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RAD1, NH2 terminal ERCC4-like helicase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_2970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625882.1">
        <property type="nucleotide sequence ID" value="XM_625882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQX0"/>
    <dbReference type="STRING" id="353152.Q5CQX0"/>
    <dbReference type="GeneID" id="3372991"/>
    <dbReference type="KEGG" id="cpv:cgd4_2970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2970"/>
    <dbReference type="InParanoid" id="Q5CQX0"/>
    <dbReference type="OrthoDB" id="361020at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000014">
        <property type="term" value="F:single-stranded DNA endodeoxyribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10150:SF0">
        <property type="entry name" value="DNA REPAIR ENDONUCLEASE XPF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="631" mass="72244" checksum="B6FF2143586BAC6B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQX4</accession>
    <name>Q5CQX4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Vacuolar sorting protein VPS52/suppressor of actin Sac2-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_2930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87816.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625878.1">
        <property type="nucleotide sequence ID" value="XM_625878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQX4"/>
    <dbReference type="STRING" id="353152.Q5CQX4"/>
    <dbReference type="GeneID" id="3372994"/>
    <dbReference type="KEGG" id="cpv:cgd4_2930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2930"/>
    <dbReference type="InParanoid" id="Q5CQX4"/>
    <dbReference type="OMA" id="NPVKYPY"/>
    <dbReference type="OrthoDB" id="19482at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032456">
        <property type="term" value="P:endocytic recycling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007258">
        <property type="entry name" value="Vps52"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190">
        <property type="entry name" value="SUPPRESSOR OF ACTIN MUTATIONS 2/VACUOLAR PROTEIN SORTING 52"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14190:SF7">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 52 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87816.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="681" mass="79346" checksum="A80923AA7F316FF0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR02</accession>
    <name>Q5CR02_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_2640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87838.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625850.1">
        <property type="nucleotide sequence ID" value="XM_625850.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR02"/>
    <dbReference type="GeneID" id="3372845"/>
    <dbReference type="KEGG" id="cpv:cgd4_2640"/>
    <dbReference type="InParanoid" id="Q5CR02"/>
    <dbReference type="OrthoDB" id="342649at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87838.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="124" mass="14554" checksum="A31EAFDBFC0D150B" modified="2005-04-12" version="1">MLIQDIDEFNCNLENRRIYLTILKEQIESARRLGVLSKIKIGRNAHKENPIGALSEVDIQSSNGSLRKLRIEDKSFSRDIVSNIYRRGLIEIPPANDAFYGRRLQKLLRRKRRSKKIAKKVRFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR48</accession>
    <name>Q5CR48_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PX domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87876.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625804.1">
        <property type="nucleotide sequence ID" value="XM_625804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR48"/>
    <dbReference type="STRING" id="353152.Q5CR48"/>
    <dbReference type="GeneID" id="3372958"/>
    <dbReference type="KEGG" id="cpv:cgd4_2120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2120"/>
    <dbReference type="InParanoid" id="Q5CR48"/>
    <dbReference type="OMA" id="KDAECMQ"/>
    <dbReference type="OrthoDB" id="10254720at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555:SF170">
        <property type="entry name" value="FI18122P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10555">
        <property type="entry name" value="SORTING NEXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="1">
        <location>
            <begin position="35"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87876.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="493" mass="56993" checksum="7E87F8E4AEE44F1C" modified="2005-04-12" version="1">MSPDSIKTENTENVGDQEQINNLIISDWGMEPKRYNYQVNVTDPENKSIGLGKYTVYLVSGVTPDGHNFSTRKRYSDFEWLRSTLVIQFPGVFIPPIPKKKKVGRFEKDFIEFRRRYLEEFLRRVFNRGYLISSNLVRTWLNRSDSGMETLKKEEANRPLFDIVTQYFSSFDNVLSTDNPNSRPGKPSNRFSVPTVDISPISEFSNRLENHFIQLEQLSEHLNTITSSYNRAHISFKEIPSLFHNISLNNTNNESRLDLSSIFQNLYNINSNSSQRHFDMLYSIIAREMNDTECMLEAVQTLEKMQCLLNTNNSAMQYSDEVNSGDLRSNSFANSNISNSSITSVVSSAAKGLVSGFSLFSSKTREGSFTSDANLSKLDRYREDQSALKTLLSAGRVVLIVHEMPHFFSEKINIFNETIQEFIIRQSQSSNIENEFWSRVLNKLKSLNQYNDNLQGQNTYHDEFYTNDSRNYVNNQYNKGNNTNEWGYEGYDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR78</accession>
    <name>Q5CR78_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_1800</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625774.1">
        <property type="nucleotide sequence ID" value="XM_625774.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR78"/>
    <dbReference type="GeneID" id="3372906"/>
    <dbReference type="KEGG" id="cpv:cgd4_1800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1800"/>
    <dbReference type="InParanoid" id="Q5CR78"/>
    <dbReference type="OMA" id="GKMSNIA"/>
    <dbReference type="OrthoDB" id="337460at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="215" mass="25315" checksum="A96490EEFBA8E3D5" modified="2005-04-12" version="1">MLSELAEDQVDFDDVALNTFFLNEEINENLFQAFMLEYNKNILVLRFNDFTSDTDKSDWLLKYCEHLSEKINSLHGTNINELQEQSIHSDYTRKKNILLILDRDFHKSLRNEPGQLSKYKFLNNVLIKYSDRLSLSVGSMGGEISLFEIILRIHELYKYGEIKYLIINQFDKLIDIDEHLSNETKSVIYSYIYSLFANISLGDKYSRELKIVIID</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR95</accession>
    <name>Q5CR95_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd4_1610</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87912.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625757.1">
        <property type="nucleotide sequence ID" value="XM_625757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR95"/>
    <dbReference type="STRING" id="353152.Q5CR95"/>
    <dbReference type="GeneID" id="3372928"/>
    <dbReference type="KEGG" id="cpv:cgd4_1610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1610"/>
    <dbReference type="InParanoid" id="Q5CR95"/>
    <dbReference type="OMA" id="CKAIRIS"/>
    <dbReference type="OrthoDB" id="8693905at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050629">
        <property type="entry name" value="STE20/SPS1-PAK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012:SF10">
        <property type="entry name" value="FI20177P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48012">
        <property type="entry name" value="STERILE20-LIKE KINASE, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="156"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="64"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="71"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="11">
        <location>
            <begin position="83"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="109"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK87912.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="601" mass="70545" checksum="DAB4C0CEEE188710" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRC0</accession>
    <name>Q5CRC0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">TRAP-C2 extracellular protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd5_3420</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626266.1">
        <property type="nucleotide sequence ID" value="XM_626266.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRC0"/>
    <dbReference type="GeneID" id="3373055"/>
    <dbReference type="KEGG" id="cpv:cgd5_3420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3420"/>
    <dbReference type="InParanoid" id="Q5CRC0"/>
    <dbReference type="OMA" id="PGKCQCN"/>
    <dbReference type="OrthoDB" id="446173at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007155">
        <property type="term" value="P:cell adhesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.320">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.470.20">
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000800">
        <property type="entry name" value="Notch_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003582">
        <property type="entry name" value="ShKT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051418">
        <property type="entry name" value="Spondin/Thrombospondin_T1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311">
        <property type="entry name" value="SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11311:SF15">
        <property type="entry name" value="SPONDIN-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00066">
        <property type="entry name" value="Notch"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00004">
        <property type="entry name" value="NL"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00254">
        <property type="entry name" value="ShKT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="11"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50258">
        <property type="entry name" value="LNR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="10"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 7" id="KW-0732">Signal</keyword>
    <keyword evidence="6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254874" evidence="7">
        <location>
            <begin position="24"/>
            <end position="3869"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="3757"/>
            <end position="3781"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="8">
        <location>
            <begin position="100"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="8">
        <location>
            <begin position="1086"/>
            <end position="1126"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="8">
        <location>
            <begin position="1529"/>
            <end position="1572"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="8">
        <location>
            <begin position="1684"/>
            <end position="1727"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="8">
        <location>
            <begin position="1910"/>
            <end position="1953"/>
        </location>
    </feature>
    <feature type="domain" description="LNR" evidence="8">
        <location>
            <begin position="3156"/>
            <end position="3193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="657"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1566"/>
            <end position="1609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1723"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1947"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2464"/>
            <end position="2502"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2792"/>
            <end position="2850"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="2939"/>
            <end position="2958"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="3652"/>
            <end position="3685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1574"/>
            <end position="1602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1732"/>
            <end position="1760"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1955"/>
            <end position="1970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1979"/>
            <end position="1994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="2468"/>
            <end position="2477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="2808"/>
            <end position="2841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="3659"/>
            <end position="3669"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="3670"/>
            <end position="3679"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="3869" mass="429504" checksum="555642E4A7154199" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRE2</accession>
    <name>Q5CRE2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">LPS glycosyltransferase of possible cyanobacterial origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_3140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88018.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626244.1">
        <property type="nucleotide sequence ID" value="XM_626244.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRE2"/>
    <dbReference type="GeneID" id="3373256"/>
    <dbReference type="KEGG" id="cpv:cgd5_3140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3140"/>
    <dbReference type="InParanoid" id="Q5CRE2"/>
    <dbReference type="OMA" id="IEREACH"/>
    <dbReference type="OrthoDB" id="196493at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003844">
        <property type="term" value="F:1,4-alpha-glucan branching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03801">
        <property type="entry name" value="GT4_PimA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028098">
        <property type="entry name" value="Glyco_trans_4-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43651:SF3">
        <property type="entry name" value="1,4-ALPHA-GLUCAN-BRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13439">
        <property type="entry name" value="Glyco_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase subfamily 4-like N-terminal" evidence="4">
        <location>
            <begin position="1246"/>
            <end position="1435"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="3">
        <location>
            <begin position="1449"/>
            <end position="1612"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1182"/>
            <end position="1201"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1839"/>
            <end position="1869"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1182"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1858"/>
            <end position="1869"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF13439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88018.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2069" mass="234829" checksum="7037D5E7ACF00914" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRE3</accession>
    <name>Q5CRE3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_3130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88017.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626243.1">
        <property type="nucleotide sequence ID" value="XM_626243.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373255"/>
    <dbReference type="KEGG" id="cpv:cgd5_3130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3130"/>
    <dbReference type="InParanoid" id="Q5CRE3"/>
    <dbReference type="OMA" id="RWSITPR"/>
    <dbReference type="OrthoDB" id="397227at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="197"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="954"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="1036"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2313"/>
            <end position="2330"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2337"/>
            <end position="2355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2391"/>
            <end position="2412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2448"/>
            <end position="2481"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="2493"/>
            <end position="2512"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="2752"/>
            <end position="2787"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="4350"/>
            <end position="4385"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="791"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1411"/>
            <end position="1432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1730"/>
            <end position="1764"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="3833"/>
            <end position="3853"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="97"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="107"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="793"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1750"/>
            <end position="1764"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88017.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="4780" mass="538559" checksum="3E57D74B50924F20" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRG9</accession>
    <name>Q5CRG9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">ULP1 like chllamydin domain containing protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_2810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C48 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626217.1">
        <property type="nucleotide sequence ID" value="XM_626217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRG9"/>
    <dbReference type="STRING" id="353152.Q5CRG9"/>
    <dbReference type="GeneID" id="3373241"/>
    <dbReference type="KEGG" id="cpv:cgd5_2810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2810"/>
    <dbReference type="InParanoid" id="Q5CRG9"/>
    <dbReference type="OMA" id="CENISKY"/>
    <dbReference type="OrthoDB" id="198735at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016929">
        <property type="term" value="F:deSUMOylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016926">
        <property type="term" value="P:protein desumoylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.395.10">
        <property type="entry name" value="Adenoviral Proteinase, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003653">
        <property type="entry name" value="Peptidase_C48_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606">
        <property type="entry name" value="SENTRIN/SUMO-SPECIFIC PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12606:SF1">
        <property type="entry name" value="UBIQUITIN-LIKE-SPECIFIC PROTEASE 1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02902">
        <property type="entry name" value="Peptidase_C48"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50600">
        <property type="entry name" value="ULP_PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Ubiquitin-like protease family profile" evidence="5">
        <location>
            <begin position="238"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="456" mass="53679" checksum="2301A1A27239E325" modified="2005-04-12" version="1">MRGRRNYNGNLPLKIMSSSQILSQYISLNHGPYHTEGRTSLFDKRKENFSRILNFQIPVRERFSPNKMHLNKYLPVEKPRKDILSSSLSDDLTPISKTSTIINKYQEIKSKHRVIYYEKSGSDSDDGLLKRSLEFIKRISKSNNHLEVLGSHLNSLALCERNLEDKRKEFKKLVYGLDDSQFEEQESKEKDELFVSLGVIKYKYPIECSDEELNKARSYLNSLSNRGQIVAINYKSNIELTIDLIQCLRSQQWLNDELINFYFSMLQERNDRQTSNGFKPKVWLWNSFFYTKLTCDQSNDETGYCYKNVSRWTQRKKIDLFNYDIVLLPINVNNVHWTLGVVNFKLGYIQYIDSLGGQFQDHLGCTKMSAIFFQNMNRYIQDEYFDKKKEKFPGQLKHFTRFSEPVPQQNNGSDCGVFTCMFAECISEGRSFDFDTTQIDRIREVMLVECIRNEIF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRI7</accession>
    <name>Q5CRI7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Penguin protein containing pumolio repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_2620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626199.1">
        <property type="nucleotide sequence ID" value="XM_626199.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRI7"/>
    <dbReference type="STRING" id="353152.Q5CRI7"/>
    <dbReference type="GeneID" id="3373162"/>
    <dbReference type="KEGG" id="cpv:cgd5_2620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2620"/>
    <dbReference type="InParanoid" id="Q5CRI7"/>
    <dbReference type="OMA" id="FQCFYKH"/>
    <dbReference type="OrthoDB" id="497380at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033133">
        <property type="entry name" value="PUM-HD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040059">
        <property type="entry name" value="PUM3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001313">
        <property type="entry name" value="Pumilio_RNA-bd_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13389:SF0">
        <property type="entry name" value="PUMILIO HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22493">
        <property type="entry name" value="PUF_NOP9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00025">
        <property type="entry name" value="Pumilio"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50302">
        <property type="entry name" value="PUM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50303">
        <property type="entry name" value="PUM_HD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="PUM-HD" evidence="4">
        <location>
            <begin position="27"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="repeat" description="Pumilio" evidence="2">
        <location>
            <begin position="94"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="659" mass="76265" checksum="350F2E1C2BEE1155" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRQ4</accession>
    <name>Q5CRQ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_1890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626132.1">
        <property type="nucleotide sequence ID" value="XM_626132.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRQ4"/>
    <dbReference type="STRING" id="353152.Q5CRQ4"/>
    <dbReference type="GeneID" id="3373273"/>
    <dbReference type="KEGG" id="cpv:cgd5_1890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1890"/>
    <dbReference type="InParanoid" id="Q5CRQ4"/>
    <dbReference type="OrthoDB" id="341863at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="321" mass="35489" checksum="7A18599FFEC1F606" modified="2005-04-12" version="1">MFFSQTNVGNVSTAGLGLFGSTGPGAASNSLNLSASITQTGQSITPPAIPGNSLFQLSNSQSGISNSSNLFGTSNLNNSSIGILGSTGSNVSLFGASQTQNQPQTQINPQAQYLPLNPTIGQLTNYIQSWKAEFDEIENQLRGNDKHIEYLTNNKLIEITRLCSTYKKGVERRNEEIENIKSLQFRAQDSIESVISEITTVQQLSHDITHIYDRIKDIDQNNSSRQIQPLRFPLPIFEFFCENMAKKCKGIEEIIGNLDRAVSSLREELTNATAEDVLKYIAEIINNNYEAFYDLVTKCSQLHDKTESVVNISKLHDASRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRR7</accession>
    <name>Q5CRR7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Conserved protein with N-terminal HORMA domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_1750</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626119.1">
        <property type="nucleotide sequence ID" value="XM_626119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRR7"/>
    <dbReference type="STRING" id="353152.Q5CRR7"/>
    <dbReference type="GeneID" id="3373088"/>
    <dbReference type="KEGG" id="cpv:cgd5_1750"/>
    <dbReference type="InParanoid" id="Q5CRR7"/>
    <dbReference type="OMA" id="RYMSMKL"/>
    <dbReference type="OrthoDB" id="1928087at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.900.10">
        <property type="entry name" value="HORMA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003511">
        <property type="entry name" value="HORMA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036570">
        <property type="entry name" value="HORMA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051294">
        <property type="entry name" value="HORMA_MeioticProgression"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225">
        <property type="entry name" value="HORMA DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48225:SF7">
        <property type="entry name" value="MEIOSIS-SPECIFIC PROTEIN HOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02301">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56019">
        <property type="entry name" value="The spindle assembly checkpoint protein mad2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50815">
        <property type="entry name" value="HORMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0469">Meiosis</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HORMA" evidence="6">
        <location>
            <begin position="14"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="403" mass="46602" checksum="FAE712E4EB86F0A2" modified="2005-04-12" version="1" fragment="single">TPYIVIYYQQVTDIQSLNMMRNTIRTAVSSVAYLRNLFDEEAFEDKNVSGLQLKVLRPFNQESKLILNWLEDGVFDALEKQYLKLLVFGIHGECDELIESYHFHFNYSEKGTNINLKRKSKEKETSNSQEINNFGCCTKEYARQQTVQLLRALILLTQSLSPLPESRYMSMKLWYYEDRVPNDYEPNHFRPARSSDILSFNEIPIDTVVGNVDTKFHTLSVKVKSAVENYNDSSELNLYTNLSASQLKKKEKIPEKQELLKIQTFSNDKIKERTDEELTAGSSTESKQIKLNELIPNHNGSPTDDRTIKTINSVELLEKATEVVKFLKFVNKGNLAMALDIEKERASNLIEILLDNGHLLNKVVKGKGYPVKEREIGERRVKNKSICKKRMTKRKIDEKNTKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRS3</accession>
    <name>Q5CRS3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cactin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88087.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626113.1">
        <property type="nucleotide sequence ID" value="XM_626113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRS3"/>
    <dbReference type="FunCoup" id="Q5CRS3">
        <property type="interactions" value="417"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRS3"/>
    <dbReference type="GeneID" id="3373013"/>
    <dbReference type="KEGG" id="cpv:cgd5_1690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1690"/>
    <dbReference type="InParanoid" id="Q5CRS3"/>
    <dbReference type="OMA" id="HIDFWND"/>
    <dbReference type="OrthoDB" id="265955at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019134">
        <property type="entry name" value="Cactin_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737">
        <property type="entry name" value="POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21737:SF4">
        <property type="entry name" value="SPLICING FACTOR CACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09732">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01050">
        <property type="entry name" value="CactinC_cactus"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Splicing factor Cactin C-terminal" evidence="1">
        <location>
            <begin position="394"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF09732"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88087.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="548" mass="65374" checksum="EBB659E9E884E93E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRU0</accession>
    <name>Q5CRU0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large cysteine rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1490</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626096.1">
        <property type="nucleotide sequence ID" value="XM_626096.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373279"/>
    <dbReference type="KEGG" id="cpv:cgd5_1490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1490"/>
    <dbReference type="InParanoid" id="Q5CRU0"/>
    <dbReference type="OMA" id="NTIESIC"/>
    <dbReference type="OrthoDB" id="337658at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253778" evidence="1">
        <location>
            <begin position="24"/>
            <end position="2592"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2592" mass="298652" checksum="36DB19E7DFC53470" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRX8</accession>
    <name>Q5CRX8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CCCH RNA binding domain involved in RNA metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_1070</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626058.1">
        <property type="nucleotide sequence ID" value="XM_626058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRX8"/>
    <dbReference type="STRING" id="353152.Q5CRX8"/>
    <dbReference type="GeneID" id="3373074"/>
    <dbReference type="KEGG" id="cpv:cgd5_1070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1070"/>
    <dbReference type="InParanoid" id="Q5CRX8"/>
    <dbReference type="OrthoDB" id="430732at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045892">
        <property type="term" value="P:negative regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045124">
        <property type="entry name" value="Su(sable)-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041367">
        <property type="entry name" value="Znf-CCCH_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119:SF12">
        <property type="entry name" value="PROTEIN SUPPRESSOR OF SABLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13119">
        <property type="entry name" value="ZINC FINGER CCCH DOMAIN-CONTAINING PROTEI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18044">
        <property type="entry name" value="zf-CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="35"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="93"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="253" mass="29515" checksum="CC1002B1A1622BA9" modified="2005-04-12" version="1">MNILTLSLIMSKASEDEKIIKKKITKKLALQSNKSNRLQLCTYFIKGRCKNGSSCQFKHSAIPITKKKLCWYFISGKCSKSDCQYSHEISKFPCRYLNTVGFCRNLKDCRFSHELIKTEQQREEFVRENKDYLLLPHKDGGPSEIHVNHMWWVPLLKKIIKEDEEIAAKRSFIKRLYNESETSVPKGICSSIEPRFAINISNRSENICLTDTTSEYSSKEYNSNTSNSFNRIFERKEFNIKKLYSNLFGNSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRZ5</accession>
    <name>Q5CRZ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88147.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626041.1">
        <property type="nucleotide sequence ID" value="XM_626041.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRZ5"/>
    <dbReference type="GeneID" id="3373134"/>
    <dbReference type="KEGG" id="cpv:cgd5_890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_890"/>
    <dbReference type="InParanoid" id="Q5CRZ5"/>
    <dbReference type="OMA" id="CNIREEY"/>
    <dbReference type="OrthoDB" id="18786at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019465">
        <property type="entry name" value="Cog5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13228:SF3">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88147.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="952" mass="110781" checksum="16172AA4C41301F6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS14</accession>
    <name>Q5CS14_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Thioredoxin domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the thioredoxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88158.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626022.1">
        <property type="nucleotide sequence ID" value="XM_626022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS14"/>
    <dbReference type="STRING" id="353152.Q5CS14"/>
    <dbReference type="GeneID" id="3373165"/>
    <dbReference type="KEGG" id="cpv:cgd5_660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_660"/>
    <dbReference type="InParanoid" id="Q5CS14"/>
    <dbReference type="OMA" id="GATWCKP"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045454">
        <property type="term" value="P:cell redox homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43601:SF3">
        <property type="entry name" value="THIOREDOXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="3">
        <location>
            <begin position="79"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88158.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="200" mass="23563" checksum="54D70E89221F8D38" modified="2005-04-12" version="1">MIICLGPFCIPVWNIFLFLFALIGPIINFLKRIFLGKKSNIKNRGELTIGNHEKILEEKDLAEIGIESHLFRESYEKILKLVESRNVLELENINDWEICKLLGKNLELPILVDYYADWCNPCKKISTTFKKLCKEYNGIFIKIDYETHTNFCYDMGVFSLPTFHFWILDNNSYILVDKLERSDSKELENLLVKNKFKIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS88</accession>
    <name>Q5CS88_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">CHD3 ortholog with 2x chromodomains plus SNF2 ATpase (2chromo+helicase+Znf_NFX)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd1_3670</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628179.1">
        <property type="nucleotide sequence ID" value="XM_628179.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS88"/>
    <dbReference type="GeneID" id="3371517"/>
    <dbReference type="KEGG" id="cpv:cgd1_3670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3670"/>
    <dbReference type="InParanoid" id="Q5CS88"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056302">
        <property type="entry name" value="CHD1-2/Hrp3_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025260">
        <property type="entry name" value="CHD1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023780">
        <property type="entry name" value="Chromo_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023779">
        <property type="entry name" value="Chromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF14">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00385">
        <property type="entry name" value="Chromo"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23588">
        <property type="entry name" value="HTH_CHD1_Hrp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01176">
        <property type="entry name" value="DUF4208"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <sequence length="2055" mass="234258" checksum="905C4782CCE8AAD0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSE7</accession>
    <name>Q5CSE7_CRYPI</name>
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        <recommendedName>
            <fullName evidence="10">Triosephosphate isomerase</fullName>
            <ecNumber evidence="10">5.3.1.1</ecNumber>
        </recommendedName>
    </protein>
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        <name evidence="11" type="ORF">cgd1_3040</name>
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        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="journal article" date="2011" name="Acta Crystallogr. F" volume="67" first="1095" last="1099">
            <title>Structure of triosephosphate isomerase from Cryptosporidium parvum.</title>
            <authorList>
                <person name="Nguyen T.N."/>
                <person name="Abendroth J."/>
                <person name="Leibly D.J."/>
                <person name="Le K.P."/>
                <person name="Guo W."/>
                <person name="Kelley A."/>
                <person name="Stewart L."/>
                <person name="Myler P.J."/>
                <person name="Van Voorhis W.C."/>
            </authorList>
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            <dbReference type="DOI" id="10.1107/s1744309111019178"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS)</scope>
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        <text evidence="9">Catalyzes the interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic and gluconeogenic pathways.</text>
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        <reaction evidence="8">
            <text>D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate</text>
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            <dbReference type="ChEBI" id="CHEBI:57642"/>
            <dbReference type="ChEBI" id="CHEBI:59776"/>
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    </comment>
    <comment type="pathway">
        <text evidence="2 10">Carbohydrate biosynthesis; gluconeogenesis.</text>
    </comment>
    <comment type="pathway">
        <text evidence="1 10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate from glycerone phosphate: step 1/1.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Homodimer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the triosephosphate isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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        <property type="molecule type" value="Genomic_DNA"/>
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        <property type="resolution" value="1.55 A"/>
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        <property type="entry name" value="TrioseP_Isoase_bac/euk"/>
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        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
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    </dbReference>
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        <property type="entry name" value="TRIOSEPHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
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    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="5 10" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="6 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="7 10 11" id="KW-0413">Isomerase</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
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        <source>
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        <source>
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    </evidence>
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        <source>
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        <source>
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    <evidence type="ECO:0000313" key="12">
        <source>
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    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="3KRS"/>
        </source>
    </evidence>
    <sequence length="250" mass="27384" checksum="9C2F0EAFECC92C3F" modified="2005-04-12" version="1">MSRKYFVGGNFKCNGTKESLKTLIDSFKQVESSNSEVYVFPTSLHISLVKEFFGNDHPGVFKIGSQNISCTGNGAFTGEVSCEMLKDMDVDCSLVGHSERRQYYSETDQIVNNKVKKGLENGLKIVLCIGESLSERETGKTNDVIQKQLTEALKDVSDLSNLVIAYEPIWAIGTGVVATPGQAQEAHAFIREYVTRMYNPQVSSNLRIIYGGSVTPDNCNELIKCADIDGFLVGGASLKPTFAKIIESAQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSH0</accession>
    <name>Q5CSH0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Centromere/kinetochore protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88356.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628097.1">
        <property type="nucleotide sequence ID" value="XM_628097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSH0"/>
    <dbReference type="SMR" id="Q5CSH0"/>
    <dbReference type="STRING" id="353152.Q5CSH0"/>
    <dbReference type="GeneID" id="3371724"/>
    <dbReference type="KEGG" id="cpv:cgd1_2740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2740"/>
    <dbReference type="InParanoid" id="Q5CSH0"/>
    <dbReference type="OMA" id="HHLLTMG"/>
    <dbReference type="OrthoDB" id="534815at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990423">
        <property type="term" value="C:RZZ complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048343">
        <property type="entry name" value="ZW10_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205">
        <property type="entry name" value="CENTROMERE/KINETOCHORE PROTEIN ZW10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12205:SF0">
        <property type="entry name" value="CENTROMERE_KINETOCHORE PROTEIN ZW10 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20666">
        <property type="entry name" value="ZW10_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Centromere/kinetochore protein zw10 C-terminal" evidence="1">
        <location>
            <begin position="527"/>
            <end position="656"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF20666"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88356.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="861" mass="97658" checksum="185A673D8A8D3D0C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSI8</accession>
    <name>Q5CSI8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TRAFAC type P-loop GTpase that may be related to kinesin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628079.1">
        <property type="nucleotide sequence ID" value="XM_628079.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSI8"/>
    <dbReference type="GeneID" id="3371697"/>
    <dbReference type="KEGG" id="cpv:cgd1_2530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2530"/>
    <dbReference type="InParanoid" id="Q5CSI8"/>
    <dbReference type="OMA" id="CIRRTMA"/>
    <dbReference type="OrthoDB" id="344025at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="1">
        <location>
            <begin position="12"/>
            <end position="296"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1298" mass="149031" checksum="2228C57D0936E936" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSL7</accession>
    <name>Q5CSL7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">GYF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88390.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628050.1">
        <property type="nucleotide sequence ID" value="XM_628050.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSL7"/>
    <dbReference type="GeneID" id="3371680"/>
    <dbReference type="KEGG" id="cpv:cgd1_2160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2160"/>
    <dbReference type="InParanoid" id="Q5CSL7"/>
    <dbReference type="OMA" id="YICATAW"/>
    <dbReference type="OrthoDB" id="360388at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18186">
        <property type="entry name" value="BTB_POZ_ZBTB_KLHL-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052407">
        <property type="entry name" value="BTB_POZ_domain_cont_9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306">
        <property type="entry name" value="BTB/POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46306:SF1">
        <property type="entry name" value="BTB_POZ DOMAIN-CONTAINING PROTEIN 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="1">
        <location>
            <begin position="41"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88390.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="749" mass="86615" checksum="0648D2E715AF04F0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSM9</accession>
    <name>Q5CSM9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_2020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88401.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628038.1">
        <property type="nucleotide sequence ID" value="XM_628038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSM9"/>
    <dbReference type="GeneID" id="3371652"/>
    <dbReference type="KEGG" id="cpv:cgd1_2020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2020"/>
    <dbReference type="InParanoid" id="Q5CSM9"/>
    <dbReference type="OrthoDB" id="343521at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254479" evidence="2">
        <location>
            <begin position="19"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88401.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="206" mass="23559" checksum="796E2D06B99EA214" modified="2005-04-12" version="1">MKMIKLFIALILSKIVLNLSSLIGPNQIHLYPSFENSPFITNSWTIGIFVRLKISLWAPLFEDVTDQKLFREILTLCINRGIPPPQPPIFIRILEYEHLTGLTGILFEFPKNDRTNRIVNRGNILQFLMQCREDKLGGEAHIASNILLRNSPTVQNVSSMQEFKLKKIEEDYSMATTFTITFLMVATTLSVISAYVIYYSVAKNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSN4</accession>
    <name>Q5CSN4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RPB7 subunit of the RNA polymerase III, OB fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_1960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628033.1">
        <property type="nucleotide sequence ID" value="XM_628033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSN4"/>
    <dbReference type="FunCoup" id="Q5CSN4">
        <property type="interactions" value="365"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSN4"/>
    <dbReference type="GeneID" id="3371358"/>
    <dbReference type="KEGG" id="cpv:cgd1_1960"/>
    <dbReference type="InParanoid" id="Q5CSN4"/>
    <dbReference type="OMA" id="LGPTLWW"/>
    <dbReference type="OrthoDB" id="10256606at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04330">
        <property type="entry name" value="RNAP_III_Rpc25_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.120">
        <property type="entry name" value="RNA polymerase Rpb7-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013238">
        <property type="entry name" value="RNA_pol_III_Rbc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036898">
        <property type="entry name" value="RNA_pol_Rpb7-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045113">
        <property type="entry name" value="Rpb7-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II, III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12709:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08292">
        <property type="entry name" value="RNA_pol_Rbc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88798">
        <property type="entry name" value="N-terminal, heterodimerisation domain of RBP7 (RpoE)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="RNA polymerase III subunit Rpc25" evidence="5">
        <location>
            <begin position="109"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="209" mass="23861" checksum="D96353824A247459" modified="2005-04-12" version="1" fragment="single">YNNINCFYTMFGVITIDDQINVFPNELNHFSEIHLKDIQNINPRINDPLVILRNRINDKYLNKVVKNAGLMIYFVGFDDVDHADIDNDEGGLLFCVTFKMISFRPYVGEVIEGVVIDSDSTGLTVSLGFFSDIKIPCNDLREPKSIDSNTKIWSWDYENHKLCYLIDSTIRFKVSSVVFNDQSHDNSVSSMVVVGNVQNDGLGMISWWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSN8</accession>
    <name>Q5CSN8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Predicted DNAJ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_1910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88407.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628029.1">
        <property type="nucleotide sequence ID" value="XM_628029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSN8"/>
    <dbReference type="GeneID" id="3371658"/>
    <dbReference type="KEGG" id="cpv:cgd1_1910"/>
    <dbReference type="InParanoid" id="Q5CSN8"/>
    <dbReference type="OMA" id="ENIMAAK"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="265"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="196"/>
            <end position="208"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="331" mass="37947" checksum="BB9296DD572BE99F" modified="2005-04-12" version="1">MNLINKLYRIYKREKKEDLRISDKEEPLIISKTRMALLELEIKTLAYILSRELKTSSQISNLSEIKWAEITTDDLDRLESILFENVYEIEINPIVKSLISILRGLLDTRNKFFNGKAMPFYVKLKNENVQSTFILEESVNFPFRNDRLIKQCENINSSNATPKSYFSSRTPRNLPDFNQKVELPIKSRSNHINLISSTPRSTSCQTPRTKNHMKHTNLDYSTPKSEINKKNYYIFSDSNTPRRSSKTGICGNSKISNNQQGSIMAAKALLGLSVNIPATEQDIRKAYLKAAMKWHPDKMNSSTNGKSHICFTAIQNAMEILLQNISKNGEV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSS8</accession>
    <name>Q5CSS8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted membrane associated protein, 4 transmembrane domains and signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88441.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627989.1">
        <property type="nucleotide sequence ID" value="XM_627989.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSS8"/>
    <dbReference type="GeneID" id="3371614"/>
    <dbReference type="KEGG" id="cpv:cgd1_1480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1480"/>
    <dbReference type="InParanoid" id="Q5CSS8"/>
    <dbReference type="OMA" id="TFRTEET"/>
    <dbReference type="OrthoDB" id="341836at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="24"/>
            <end position="52"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="72"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="133"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88441.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="227" mass="25278" checksum="7F9F26D006B99CF1" modified="2005-04-12" version="1">MFTYSVLGFSYRAEETPFTKKLKYAFAFILFLQFIVLLMRIVTLTDVISTFFEGWMIYLGYVVYTEKSPCAFFLFITISFVRGILLSLIAFEWIKRNTLLFSEIKLVDKLKFAITIATPILSVLACIISYNIFKNIHFVEETDELLNQFINPWNGANTGALANENTASGANEAGNPSTANINISNTSAPSPVMYTPFTGKSYKLSDISSSSNSAAGQAGNYPIYKGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CST0</accession>
    <name>Q5CST0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_1460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627987.1">
        <property type="nucleotide sequence ID" value="XM_627987.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CST0"/>
    <dbReference type="GeneID" id="3371618"/>
    <dbReference type="KEGG" id="cpv:cgd1_1460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1460"/>
    <dbReference type="InParanoid" id="Q5CST0"/>
    <dbReference type="OMA" id="WECTEIG"/>
    <dbReference type="OrthoDB" id="340661at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="343"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1050" mass="121608" checksum="252838021222A643" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSU7</accession>
    <name>Q5CSU7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627970.1">
        <property type="nucleotide sequence ID" value="XM_627970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSU7"/>
    <dbReference type="GeneID" id="3371593"/>
    <dbReference type="KEGG" id="cpv:cgd1_1260"/>
    <dbReference type="InParanoid" id="Q5CSU7"/>
    <dbReference type="OMA" id="CEYLYCS"/>
    <dbReference type="OrthoDB" id="342996at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="56"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="289" mass="33009" checksum="12455B6A8622A4E6" modified="2005-04-12" version="1">MASDESEPVDPFDNKDFLINSVSSLTSNAIRFGVYHYVNKRDSKMTGVKSSENLETSEKSDKKSEKKSEKKSEKKSENKSESKSDNKSEKNKNNLRPEKESNESQKEKSGSRMKYWWSKYIRRQKKKKEDSKEKQTNTNQNQIDSCEYLFFGSDPGNKSNSTFGNPQATRKLFIQDMTSNEDVMNSNYNGNKMRPETYVPLEIKTSIFAAYFAAEPVVIHFSKTISRNRRVKYGQEIAVAEAFPRTINNSLSSIILARCDGTISIINQTKGLPIQSTRMFLVITCNDTV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT38</accession>
    <name>Q5CT38_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627879.1">
        <property type="nucleotide sequence ID" value="XM_627879.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT38"/>
    <dbReference type="GeneID" id="3371430"/>
    <dbReference type="KEGG" id="cpv:cgd1_170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_170"/>
    <dbReference type="InParanoid" id="Q5CT38"/>
    <dbReference type="OMA" id="ANTVIEC"/>
    <dbReference type="OrthoDB" id="338493at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="183"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="76"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="208"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="285" mass="32508" checksum="E8DA6E223BFF37DA" modified="2005-04-12" version="1">MNTHNRSSTTDYSCYYDFSNAHEYYQKFDNTMFMNQNNSQYSGSIYNKGLSAQGPNFLHSNKMNLSTVKLDVNNNAPALMNTLIEKNKEIKNMEKELKIVNESNIFLNNKIEMLKILAANFGATQEDIEATMSTNDIFCIPKPSINVNYPQTDSSYENLHEKIDDELDDLIVSDKNIINLNIDDPVKPFNDEQSNESKNTSKSTRIKQRNEDQSEKKVDLSPKNLLKRSSTLLKATKSLTNSIQAQKCTNNKYLTGTRFGPSIRQKTMMQANANKRLLLSKAKNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="114" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT98</accession>
    <name>Q5CT98_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Putative ABC transporter with 2x AAA and 11+ transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_3870</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626571.1">
        <property type="nucleotide sequence ID" value="XM_626571.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT98"/>
    <dbReference type="GeneID" id="3373404"/>
    <dbReference type="KEGG" id="cpv:cgd2_3870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3870"/>
    <dbReference type="InParanoid" id="Q5CT98"/>
    <dbReference type="OMA" id="RNINMNI"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF443">
        <property type="entry name" value="MULTIDRUG-RESISTANCE LIKE PROTEIN 1, ISOFORM I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3 10 13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="100"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="147"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="344"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="435"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1146"/>
            <end position="1171"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1191"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1288"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1386"/>
            <end position="1406"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="1426"/>
            <end position="1448"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="12">
        <location>
            <begin position="392"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="11">
        <location>
            <begin position="680"/>
            <end position="950"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="969"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1083"/>
            <end position="1109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1724"/>
            <end position="1744"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="970"/>
            <end position="1010"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="1724"/>
            <end position="1739"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1928" mass="223562" checksum="5B6F7689F8EAAF4F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTE5</accession>
    <name>Q5CTE5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ser/Thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_3340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88689.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626524.1">
        <property type="nucleotide sequence ID" value="XM_626524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTE5"/>
    <dbReference type="STRING" id="353152.Q5CTE5"/>
    <dbReference type="GeneID" id="3373767"/>
    <dbReference type="KEGG" id="cpv:cgd2_3340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3340"/>
    <dbReference type="InParanoid" id="Q5CTE5"/>
    <dbReference type="OrthoDB" id="441869at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031251">
        <property type="term" value="C:PAN complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000289">
        <property type="term" value="P:nuclear-transcribed mRNA poly(A) tail shortening"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3700">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.5160">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030844">
        <property type="entry name" value="PAN3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041332">
        <property type="entry name" value="Pan3_CK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272">
        <property type="entry name" value="DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12272:SF11">
        <property type="entry name" value="PAN2-PAN3 DEADENYLATION COMPLEX SUBUNIT PAN3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18101">
        <property type="entry name" value="Pan3_CK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="355"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="181"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="351"/>
            <end position="370"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="41"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="188"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="230"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="7">
        <location>
            <begin position="355"/>
            <end position="370"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="773" mass="81579" checksum="9E217BF3BEBCF6AF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTG7</accession>
    <name>Q5CTG7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CpTSP10 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_3080</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88706.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626502.1">
        <property type="nucleotide sequence ID" value="XM_626502.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTG7"/>
    <dbReference type="STRING" id="353152.Q5CTG7"/>
    <dbReference type="GeneID" id="3373566"/>
    <dbReference type="KEGG" id="cpv:cgd2_3080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3080"/>
    <dbReference type="InParanoid" id="Q5CTG7"/>
    <dbReference type="OMA" id="WRMRTCT"/>
    <dbReference type="OrthoDB" id="412268at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.100.10:FF:000019">
        <property type="entry name" value="Thrombospondin type 1 domain containing 7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.20.10">
        <property type="entry name" value="Plasminogen Kringle 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000001">
        <property type="entry name" value="Kringle"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013806">
        <property type="entry name" value="Kringle-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038178">
        <property type="entry name" value="Kringle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039942">
        <property type="entry name" value="SBSPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044004">
        <property type="entry name" value="TSP1_spondin_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920">
        <property type="entry name" value="RPE-SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920:SF5">
        <property type="entry name" value="SMB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00051">
        <property type="entry name" value="Kringle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF19028">
        <property type="entry name" value="TSP1_spondin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00130">
        <property type="entry name" value="KR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57440">
        <property type="entry name" value="Kringle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50070">
        <property type="entry name" value="KRINGLE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="1" id="KW-0420">Kringle</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="364"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Kringle" evidence="6">
        <location>
            <begin position="168"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88706.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="391" mass="42989" checksum="8852CB8CC9468441" modified="2007-04-03" version="1">MIKYKAIGKYLILLCYAFNIFLSLVFCQELTSILNPEGGGGFSCNYTNAEYTCGGYSVTPWSSWGICSGCNGVITRQRSISGSATQGGPSTTERVKCLNNQSCEPCTYTQWSSWSACSDTCESGTKYRTRRVNSNVDCGVSEGELKLIETVSCKNDPCKCDETIRGENGLYYRGCQKYSRSGQKCLNWLSLKFDAFDYLATLENSGIADHSFCRNPISNNTLVPTIWCYVSASPLIPQLCDPVPTDCVVSEWEQWSSCSSTCEEGKITRTRTIIQESLHGGVECPVDLEQVQDCSVDVICPVDCILGSWSHWSSCSVECGKGNSTRSRSILTRPRGTGAVCQEYLQTKSCEGEGCMSFWEKNKYSIIGFAALGVVLIISIIYILIPSNNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTI1</accession>
    <name>Q5CTI1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Large WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_2910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88719.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626488.1">
        <property type="nucleotide sequence ID" value="XM_626488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTI1"/>
    <dbReference type="FunCoup" id="Q5CTI1">
        <property type="interactions" value="198"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTI1"/>
    <dbReference type="GeneID" id="3373463"/>
    <dbReference type="KEGG" id="cpv:cgd2_2910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2910"/>
    <dbReference type="InParanoid" id="Q5CTI1"/>
    <dbReference type="OMA" id="VYEWQSE"/>
    <dbReference type="OrthoDB" id="3142434at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011045">
        <property type="entry name" value="N2O_reductase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027145">
        <property type="entry name" value="PWP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858:SF0">
        <property type="entry name" value="PERIODIC TRYPTOPHAN PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19858">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="12"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50974">
        <property type="entry name" value="Nitrous oxide reductase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="412"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="435"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="524"/>
            <end position="560"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="572"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="626"/>
            <end position="645"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="626"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88719.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1003" mass="111136" checksum="AB4C069FBEF338F5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTQ3</accession>
    <name>Q5CTQ3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Lipoprotein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88782.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626416.1">
        <property type="nucleotide sequence ID" value="XM_626416.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTQ3"/>
    <dbReference type="GeneID" id="3373526"/>
    <dbReference type="KEGG" id="cpv:cgd2_2110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2110"/>
    <dbReference type="InParanoid" id="Q5CTQ3"/>
    <dbReference type="OMA" id="ISSFMQH"/>
    <dbReference type="OrthoDB" id="340861at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88782.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="20291" checksum="659EA3D50E5C7B1F" modified="2005-04-12" version="1">MHKYYRLFFGLIFLFMGCGYIGSIRVNLLGNRALYSTFLEQQATLEEMVKELSSNTALGKTRFGDPITDKNNQSSGSAPTVVRHGRDTIALSIGYGPLSGLGELPFFGNTGPKVPIIITSPQPILDIESLSASYQKEANTPGSAAYVDEQALAQAVTNPKVNSDQVAVSLKSTLQNAAYFAADAELYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTT8</accession>
    <name>Q5CTT8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Extracellular protein with signal peptide, 5xEGF and apple domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd2_1590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626381.1">
        <property type="nucleotide sequence ID" value="XM_626381.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTT8"/>
    <dbReference type="STRING" id="353152.Q5CTT8"/>
    <dbReference type="GeneID" id="3373716"/>
    <dbReference type="KEGG" id="cpv:cgd2_1590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1590"/>
    <dbReference type="InParanoid" id="Q5CTT8"/>
    <dbReference type="OMA" id="LNECEDM"/>
    <dbReference type="OrthoDB" id="10045365at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01100">
        <property type="entry name" value="APPLE_Factor_XI_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.25.10:FF:000005">
        <property type="entry name" value="Fibrillin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.4.10">
        <property type="entry name" value="Hepatocyte Growth Factor"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050751">
        <property type="entry name" value="ECM_structural_protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000742">
        <property type="entry name" value="EGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001881">
        <property type="entry name" value="EGF-like_Ca-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000152">
        <property type="entry name" value="EGF-type_Asp/Asn_hydroxyl_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009030">
        <property type="entry name" value="Growth_fac_rcpt_cys_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049883">
        <property type="entry name" value="NOTCH1_EGF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003609">
        <property type="entry name" value="Pan_app"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24034:SF209">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07645">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00024">
        <property type="entry name" value="PAN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00223">
        <property type="entry name" value="APPLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00181">
        <property type="entry name" value="EGF"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00179">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57196">
        <property type="entry name" value="EGF/Laminin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57184">
        <property type="entry name" value="Growth factor receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57414">
        <property type="entry name" value="Hairpin loop containing domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00010">
        <property type="entry name" value="ASX_HYDROXYL"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50026">
        <property type="entry name" value="EGF_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50948">
        <property type="entry name" value="PAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1 6" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="5" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="34"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="82"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="domain" description="EGF-like" evidence="8">
        <location>
            <begin position="127"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="domain" description="Apple" evidence="9">
        <location>
            <begin position="359"/>
            <end position="427"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="304"/>
            <end position="331"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50948"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="614" mass="69233" checksum="2FD6477D22AE8104" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTW1</accession>
    <name>Q5CTW1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Possible phosphatidylinositol 3-and 4-kinase family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_1340</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626358.1">
        <property type="nucleotide sequence ID" value="XM_626358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTW1"/>
    <dbReference type="STRING" id="353152.Q5CTW1"/>
    <dbReference type="GeneID" id="3373575"/>
    <dbReference type="KEGG" id="cpv:cgd2_1340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1340"/>
    <dbReference type="InParanoid" id="Q5CTW1"/>
    <dbReference type="OMA" id="TMDCYIN"/>
    <dbReference type="OrthoDB" id="5839at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016301">
        <property type="term" value="F:kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044571">
        <property type="entry name" value="P4KG1-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45800:SF11">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 3-KINASE-RELATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45800">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL 4-KINASE GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="7">
        <location>
            <begin position="149"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="550"/>
            <end position="578"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="678" mass="77994" checksum="16FFA92FA406584C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU61</accession>
    <name>Q5CU61_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">E3 ubiquitin-protein ligase</fullName>
            <ecNumber evidence="10">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd3_4090</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="2 10">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="similarity">
        <text evidence="8 10">Belongs to the E3 ubiquitin-protein ligase UBR1-like family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626953.1">
        <property type="nucleotide sequence ID" value="XM_626953.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU61"/>
    <dbReference type="GeneID" id="3373898"/>
    <dbReference type="KEGG" id="cpv:cgd3_4090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4090"/>
    <dbReference type="InParanoid" id="Q5CU61"/>
    <dbReference type="OMA" id="TENCTIQ"/>
    <dbReference type="OrthoDB" id="340511at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071596">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process via the N-end rule pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd19673">
        <property type="entry name" value="UBR-box_UBR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.10.110.30:FF:000002">
        <property type="entry name" value="Putative e3 ubiquitin-protein ligase ubr3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.110.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044046">
        <property type="entry name" value="E3_ligase_UBR-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039164">
        <property type="entry name" value="UBR1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003126">
        <property type="entry name" value="Znf_UBR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497:SF24">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21497">
        <property type="entry name" value="UBIQUITIN LIGASE E3 ALPHA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18995">
        <property type="entry name" value="PRT6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02207">
        <property type="entry name" value="zf-UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00396">
        <property type="entry name" value="ZnF_UBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51157">
        <property type="entry name" value="ZF_UBR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 10" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="7 10" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="UBR-type" evidence="11">
        <location>
            <begin position="247"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="UBR-type" evidence="9">
        <location>
            <begin position="247"/>
            <end position="318"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046341"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU366018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2878" mass="334868" checksum="82C1A3D097B6B8E6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUG3</accession>
    <name>Q5CUG3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Probable phosphatidylserine/phosphatidylglycerophosphate/cardiolipi n synthase, 2x SMART_PLDc domains, possible bacterial origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626851.1">
        <property type="nucleotide sequence ID" value="XM_626851.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUG3"/>
    <dbReference type="FunCoup" id="Q5CUG3">
        <property type="interactions" value="14"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUG3"/>
    <dbReference type="GeneID" id="3373773"/>
    <dbReference type="KEGG" id="cpv:cgd3_2940"/>
    <dbReference type="InParanoid" id="Q5CUG3"/>
    <dbReference type="OMA" id="WLNFEVT"/>
    <dbReference type="OrthoDB" id="14911at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030572">
        <property type="term" value="F:phosphatidyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd09110">
        <property type="entry name" value="PLDc_CLS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09159">
        <property type="entry name" value="PLDc_ybhO_like_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.870.10">
        <property type="entry name" value="Endonuclease Chain A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025202">
        <property type="entry name" value="PLD-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001736">
        <property type="entry name" value="PLipase_D/transphosphatidylase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248">
        <property type="entry name" value="CARDIOLIPIN SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21248:SF22">
        <property type="entry name" value="PHOSPHOLIPASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13091">
        <property type="entry name" value="PLDc_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00155">
        <property type="entry name" value="PLDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56024">
        <property type="entry name" value="Phospholipase D/nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50035">
        <property type="entry name" value="PLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PLD phosphodiesterase" evidence="1">
        <location>
            <begin position="173"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="476" mass="55685" checksum="7FEE5B3B301A2AB5" modified="2005-04-12" version="1" fragment="single">ACKEIPYFFFLMKRKDKNEIINTNYIASKPWLAEEVNNRLKERDNIFNVCEDEFESNKWFQLMNKFSKYGEITRGNKIKLFENSRDSYLSMIESIDSAKKRVWFETYIFEECETGEKFVDSFCEASQRGCEVILLLDAFGSSKFPKRWEQKLLKNNVKVIWFNPISQIFKDTFLFRNHRKLLIADEKAYCGSINITNRINDSSLNDEANIKNYNIICNSAYKKLIFLFKQVIYSISPIKVNKLCFYDVHAEIEGPATYDLGKVFIDSLKESKCGQIPIIFQRPKEIKNGTILQVLYSNTRRQHRGIQNVLNIATKNSNSYIYLTTSYFFPPSFLRRAIQTAINNNVKVSMLLSGRSDIPGDTIATKYLIKRFIQNNVRFFFTRNIHCHAKYITIDGIWSSFGSFNWDGFSANRNLEVSVASFDSKIASQLMKMHSKMTHSFQSTEQTINQWNEQSRLTRVCSKAAYMLIKFVNKYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUK7</accession>
    <name>Q5CUK7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein with gyf domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89074.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626807.1">
        <property type="nucleotide sequence ID" value="XM_626807.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUK7"/>
    <dbReference type="GeneID" id="3373914"/>
    <dbReference type="KEGG" id="cpv:cgd3_2450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2450"/>
    <dbReference type="InParanoid" id="Q5CUK7"/>
    <dbReference type="OMA" id="NIKECAM"/>
    <dbReference type="OrthoDB" id="6415790at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003169">
        <property type="entry name" value="GYF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035445">
        <property type="entry name" value="GYF-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02213">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55277">
        <property type="entry name" value="GYF domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50829">
        <property type="entry name" value="GYF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GYF" evidence="1">
        <location>
            <begin position="279"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89074.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="509" mass="59361" checksum="479227686B8C1C31" modified="2005-04-12" version="1">MDQELGLSSGTNTHHIELSIYLGSISVTISDDNQVNCRFFSLTVDIEPSFNLENSLQEINTQTQNIFDYNDSEIDDCEKTQFCTSWYEITDAPLHATYGIFSSEINGIIKECNINQDIYLNLKLPIWVSNMAKQFYNAYNQIGFENFLLTVLQLRITIWATKNSTIESAEIFEVGETIIKVSEDHILSKNSFYFIHRIPEHDAFAIKEYSGNDKEYTIGILKCFFNSRPVIIKNINNNLIDICKNNATPCDFSKENFELIQKLRISQENVRMQLHDIVPLKWEYLDDNNVIRGPYNSIVMMSWIVKGYFGENSKLRLFDFGQECKIESTTPRCLQKFQPLSNYLSLIKSDVSRIFRCSPNDLINIGLIVKEPNHENMNLHTVEMTNKSSAREENARFIHKSQESKRIEIENAVNMLKTQFSHIEKEFQNKFRRKVQNKSMDNNFSLEATNISKDEFIKFATKNVFRQKNNALFKKWCAEYGPELVLEACAIRIQTAFRKYIKRRYLNVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUM0</accession>
    <name>Q5CUM0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_2270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89085.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626794.1">
        <property type="nucleotide sequence ID" value="XM_626794.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUM0"/>
    <dbReference type="STRING" id="353152.Q5CUM0"/>
    <dbReference type="GeneID" id="3374034"/>
    <dbReference type="KEGG" id="cpv:cgd3_2270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2270"/>
    <dbReference type="InParanoid" id="Q5CUM0"/>
    <dbReference type="OMA" id="ATYQVVH"/>
    <dbReference type="OrthoDB" id="431715at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045943">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018983">
        <property type="entry name" value="U3_snoRNA-assocProt_15_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924:SF26">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19924">
        <property type="entry name" value="UTP15 U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 15 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09384">
        <property type="entry name" value="UTP15_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 15 C-terminal" evidence="6">
        <location>
            <begin position="396"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF09384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89085.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="549" mass="62571" checksum="D18C49D02E1A2966" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUM4</accession>
    <name>Q5CUM4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">NF-kappa-B-activating protein C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_2230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NKAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626790.1">
        <property type="nucleotide sequence ID" value="XM_626790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUM4"/>
    <dbReference type="STRING" id="353152.Q5CUM4"/>
    <dbReference type="GeneID" id="3374035"/>
    <dbReference type="KEGG" id="cpv:cgd3_2230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2230"/>
    <dbReference type="InParanoid" id="Q5CUM4"/>
    <dbReference type="OrthoDB" id="273141at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040466">
        <property type="entry name" value="NKAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009269">
        <property type="entry name" value="NKAP_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087">
        <property type="entry name" value="NF-KAPPA B ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13087:SF0">
        <property type="entry name" value="NFKB ACTIVATING PROTEIN LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06047">
        <property type="entry name" value="Nkap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NF-kappa-B-activating protein C-terminal" evidence="2">
        <location>
            <begin position="108"/>
            <end position="206"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009313"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="212" mass="24620" checksum="B24601988A3B39AE" modified="2005-04-12" version="1">MEKLISWLHERTKRRRDMRKKIKNLWNEEVSLNGEQDKDISSVENIIGYFKDKRRPSFERDLSLSEDTASMSPNSDIGCDNEEKIEDDHLFGPSPSDIKKTAINQNLNYGAALLYGEGEAMAQFVQAGKRIPRRGEVGLTGEQIESFEKVGYVMSGSMHKRMTAVRIRKENQVYTVEERRNIALQNEKQRMLKESQLLGELRELIKREEKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVE7</accession>
    <name>Q5CVE7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ubiquitinyl hydrolase 1</fullName>
            <ecNumber evidence="3">3.4.19.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_4340</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).</text>
            <dbReference type="EC" id="3.4.19.12"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.19.12" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627322.1">
        <property type="nucleotide sequence ID" value="XM_627322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVE7"/>
    <dbReference type="GeneID" id="3374528"/>
    <dbReference type="KEGG" id="cpv:cgd8_4340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4340"/>
    <dbReference type="InParanoid" id="Q5CVE7"/>
    <dbReference type="OMA" id="FRIGIMQ"/>
    <dbReference type="OrthoDB" id="420187at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02661">
        <property type="entry name" value="Peptidase_C19E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF758">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00973">
        <property type="entry name" value="USP_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0788">Thiol protease</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="USP" evidence="8">
        <location>
            <begin position="109"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="765" mass="88011" checksum="7ECFFA16FC9F7717" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVF9</accession>
    <name>Q5CVF9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein with several coiled-coil regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_4200</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627310.1">
        <property type="nucleotide sequence ID" value="XM_627310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVF9"/>
    <dbReference type="STRING" id="353152.Q5CVF9"/>
    <dbReference type="GeneID" id="3374629"/>
    <dbReference type="KEGG" id="cpv:cgd8_4200"/>
    <dbReference type="InParanoid" id="Q5CVF9"/>
    <dbReference type="OMA" id="WSIRVAY"/>
    <dbReference type="OrthoDB" id="342129at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57997">
        <property type="entry name" value="Tropomyosin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="350"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="44"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="251"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="421"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="617"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="531"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="913" mass="106636" checksum="ABA8229A95D8F021" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVT1</accession>
    <name>Q5CVT1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Possible apicomplexan conserved motif</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd8_2880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">May play a role in mRNA splicing.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Part of a tri-snRNP complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SNUT3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89471.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627188.1">
        <property type="nucleotide sequence ID" value="XM_627188.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVT1"/>
    <dbReference type="STRING" id="353152.Q5CVT1"/>
    <dbReference type="GeneID" id="3374324"/>
    <dbReference type="KEGG" id="cpv:cgd8_2880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2880"/>
    <dbReference type="InParanoid" id="Q5CVT1"/>
    <dbReference type="OMA" id="QDTHNEL"/>
    <dbReference type="OrthoDB" id="21368at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013957">
        <property type="entry name" value="SNRNP27"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077">
        <property type="entry name" value="U4/U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31077:SF1">
        <property type="entry name" value="U4_U6.U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 27 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08648">
        <property type="entry name" value="SNRNP27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="U4/U6.U5 small nuclear ribonucleoprotein 27kDa protein" evidence="9">
        <location>
            <begin position="103"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="81"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="81"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00003632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89471.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="158" mass="18395" checksum="2671DF7B6ADD10C0" modified="2005-04-12" version="1">MCQNRISEHKYSRKKVVSKKDATKNLSILNKKIDATVKKLDSSKFGDSKYDDFGRLSKRAFKFQRKCETKDSIINKHEKRDLEHENITSSEKCEVESNSPLSESEVIKEMFGIERFETSKNKNHSTSSLSCFSIKSKRKYRQYMNRPGGFNRPLSPTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVU6</accession>
    <name>Q5CVU6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">[histone H3]-lysine(4) N-trimethyltransferase</fullName>
            <ecNumber evidence="2">2.1.1.354</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="22" type="ORF">cgd8_2730</name>
    </gene>
    <organism evidence="22 23">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="22 23" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="23">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + 3 S-adenosyl-L-homocysteine + 3 H(+)</text>
            <dbReference type="Rhea" id="RHEA:60260"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15547"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="EC" id="2.1.1.354"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6),N(6)-trimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60272"/>
            <dbReference type="Rhea" id="RHEA-COMP:15537"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61961"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-methyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:60268"/>
            <dbReference type="Rhea" id="RHEA-COMP:15540"/>
            <dbReference type="Rhea" id="RHEA-COMP:15543"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61929"/>
            <dbReference type="ChEBI" id="CHEBI:61976"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="22">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.354" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627173.1">
        <property type="nucleotide sequence ID" value="XM_627173.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CVU6"/>
    <dbReference type="STRING" id="353152.Q5CVU6"/>
    <dbReference type="GeneID" id="3374387"/>
    <dbReference type="KEGG" id="cpv:cgd8_2730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2730"/>
    <dbReference type="InParanoid" id="Q5CVU6"/>
    <dbReference type="OMA" id="KENDYIC"/>
    <dbReference type="OrthoDB" id="308383at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048188">
        <property type="term" value="C:Set1C/COMPASS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140999">
        <property type="term" value="F:histone H3K4 trimethyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd10518">
        <property type="entry name" value="SET_SETD1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003616">
        <property type="entry name" value="Post-SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044570">
        <property type="entry name" value="Set1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45814:SF2">
        <property type="entry name" value="HISTONE-LYSINE N-METHYLTRANSFERASE SETD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00508">
        <property type="entry name" value="PostSET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50868">
        <property type="entry name" value="POST_SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10 15" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="9" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="23" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <keyword evidence="7 16" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="19">
        <location>
            <begin position="609"/>
            <end position="667"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="18">
        <location>
            <begin position="697"/>
            <end position="751"/>
        </location>
    </feature>
    <feature type="domain" description="SET" evidence="20">
        <location>
            <begin position="2100"/>
            <end position="2220"/>
        </location>
    </feature>
    <feature type="domain" description="Post-SET" evidence="21">
        <location>
            <begin position="2228"/>
            <end position="2244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="1"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047571"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00047583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049129"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="21">
        <source>
            <dbReference type="PROSITE" id="PS50868"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="EMBL" id="EAK89458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="23">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2244" mass="261081" checksum="4116C95F88E055EA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW31</accession>
    <name>Q5CW31_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic peptide chain release factor subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_1830</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the eukaryotic release factor 1 family. Pelota subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89687.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627088.1">
        <property type="nucleotide sequence ID" value="XM_627088.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW31"/>
    <dbReference type="FunCoup" id="Q5CW31">
        <property type="interactions" value="166"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW31"/>
    <dbReference type="GeneID" id="3374409"/>
    <dbReference type="KEGG" id="cpv:cgd8_1830"/>
    <dbReference type="InParanoid" id="Q5CW31"/>
    <dbReference type="OMA" id="DDLWHLK"/>
    <dbReference type="OrthoDB" id="10249111at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070651">
        <property type="term" value="P:nonfunctional rRNA decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070966">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, no-go decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070481">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, non-stop decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032790">
        <property type="term" value="P:ribosome disassembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071025">
        <property type="term" value="P:RNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.870:FF:000002">
        <property type="entry name" value="Protein pelota homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.870">
        <property type="entry name" value="Pelota, domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038069">
        <property type="entry name" value="Pelota/DOM34_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058547">
        <property type="entry name" value="Pelota_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004405">
        <property type="entry name" value="TF_pelota"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00111">
        <property type="entry name" value="pelota"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853">
        <property type="entry name" value="PELOTA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10853:SF0">
        <property type="entry name" value="PROTEIN PELOTA HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26356">
        <property type="entry name" value="Pelota_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159065">
        <property type="entry name" value="Dom34/Pelota N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="8">
        <location>
            <begin position="2"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="384"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009504"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89687.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="461" mass="52408" checksum="A50146476F0D7D12" modified="2005-04-12" version="1" fragment="single">KMKLLKSKNSGNGFGYVKLKIESEDDIWELYNLILSGDSVRSVTYRKTHKENTSGTVSVKVHKLVMTVIVKNTEYGGKTLRVSGFNAIDNEHVKMGQHHTLELKVGSELILYKRSWDWLARTRLDEACKKKIGTGDDILILLIGNGVANMFLVSSQKTTKLFTVSHNITRGGQNNNNSYKESKNKFFQMIIQNLVSHLNFDDLDNIILGGPGFFKDDFFKYLFDSDNQKNKEFTSILKRKKHIFIITKTSSVFQSSIDEILLSEDFQEKLKDTKAFQQVKLIQHFQYLLATNPDLVCYGLKSTENALENNAIETLMVSDALVRSDCLKIRSKLANITGMNNSMGGKTCIFSSTHNSGKTLENMSGIAAILRFPVEHLQECEVDEPNQAWETGDEGGGRDDGQDEDFDWFKKEKDEIKKHQMSQLDNNSLEKQFQQNSTISDNFLASLKSDKQDDDFFSEMD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW32</accession>
    <name>Q5CW32_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_1810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627087.1">
        <property type="nucleotide sequence ID" value="XM_627087.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW32"/>
    <dbReference type="GeneID" id="3374505"/>
    <dbReference type="KEGG" id="cpv:cgd8_1810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1810"/>
    <dbReference type="InParanoid" id="Q5CW32"/>
    <dbReference type="OMA" id="IWTELGC"/>
    <dbReference type="OrthoDB" id="343583at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029190">
        <property type="entry name" value="Rrp14/SURF6_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04935">
        <property type="entry name" value="SURF6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ribosomal RNA-processing protein 14/surfeit locus protein 6 C-terminal" evidence="2">
        <location>
            <begin position="95"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="71"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="71"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="82"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="114"/>
            <end position="124"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04935"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="257" mass="29580" checksum="B11A87F7FDA962BE" modified="2005-04-12" version="1">MTANIWKELGSFSSILGYIPYNILLASENIQNEKELNSQTRRDKFGIRNLLPAFGHIRDYFNVNKNGSNKDYQLESNTQKTSSDKSNSKLTRNDLEQRLAKKIQELKQNNVNSRRNKQNSKKSTTKTAQKAIDKKNIKPESDEIQQSESSFKFGRIIDSTLSIPSTADYLQKKESKMKKINNALNALKKEEELINSLPEEEQKAKIKEIAMEKAMKKAQGIKVKDNKSKLIKTKKTILAKKKKSRQKWAEISKNQKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW98</accession>
    <name>Q5CW98_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec14d domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89334.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627021.1">
        <property type="nucleotide sequence ID" value="XM_627021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW98"/>
    <dbReference type="GeneID" id="3374566"/>
    <dbReference type="KEGG" id="cpv:cgd8_1140"/>
    <dbReference type="InParanoid" id="Q5CW98"/>
    <dbReference type="OMA" id="SWISHIT"/>
    <dbReference type="OrthoDB" id="338761at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="1">
        <location>
            <begin position="39"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89334.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="289" mass="33998" checksum="141113195253CFDC" modified="2005-04-12" version="1">MNAIFESNNSQHKSTLNMIKENRRRILIYNLRKVLGSGIGLKHDKQPVFYIRVVDLHLKTTLSFGSISELRQLIVWELEKVIYSFSEISMKEKNFISHISLVLDFSEMGIYTCKVEFQSFMRLISEILDFYSPLLINTIIIHKSKSLKENLWYSIEPIISLLYDREIITIFTDTEEELWKLLKPMNNAILHSRGGFIPNTCLYPVCSRSTVVPNIELCIQKENDQQHETCNKYSTYKSFFLSFKPDLSIKKFINNCVSIECKSIDRSYWTEEQNVIKTEQVQKNFIYDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWF0</accession>
    <name>Q5CWF0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_5360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627854.1">
        <property type="nucleotide sequence ID" value="XM_627854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWF0"/>
    <dbReference type="GeneID" id="3375849"/>
    <dbReference type="KEGG" id="cpv:cgd6_5360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5360"/>
    <dbReference type="InParanoid" id="Q5CWF0"/>
    <dbReference type="OMA" id="FCEEIAD"/>
    <dbReference type="OrthoDB" id="340094at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5005697468" evidence="1">
        <location>
            <begin position="20"/>
            <end position="486"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="486" mass="56470" checksum="C632B930E1CAB222" modified="2005-04-12" version="1">MKLLIRLAVLLGILVGVYTNELNDDIVKEINLDQSYLKSVIDIVMDQYYFMYYHQGRRGGKGKWSNGIGGLPSPRIAKKYIMTFVQSDPEDNLFGGISLKFYIRMCTNLINHFPRLHHGVGGGILIAIHSYQEEEYTIVRGFCTEAGMMHFFKKEMESLIRESSKPNSLIPPLNKSIFDQYNVGGNWDDFVENCEDLIKEFKEINIKRDSSSKWSKIDFSEISDFCEEVSDDIYPNFSQSQKEWNHIYALQNYIIERKGEMRAPIIGIPSKKPDYYVAGRHQSSMYRKCLRALWDMFQYDDEINLKIAGINQYETLRSFCNAAKNYYTRNGRISAYPMINIGDPPRKRKLPTDEDGLVKQILEKQRNKELKEKLLTMQMRNKFEKLQEEKIKRRREIRKNIKKSKVMPTTADFPLEGILSPKENSSPEEIQDTINILNELPSTSFKEDGLLEPQPNISTIEKNSESNEELDNFGLEAANEEFNKLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWJ0</accession>
    <name>Q5CWJ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cryptopain-cysteine proteinase secreted, possible transmembrane domain near N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_4880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90067.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627814.1">
        <property type="nucleotide sequence ID" value="XM_627814.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWJ0"/>
    <dbReference type="STRING" id="353152.Q5CWJ0"/>
    <dbReference type="MEROPS" id="C01.148"/>
    <dbReference type="GeneID" id="3375812"/>
    <dbReference type="KEGG" id="cpv:cgd6_4880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4880"/>
    <dbReference type="InParanoid" id="Q5CWJ0"/>
    <dbReference type="OMA" id="EGETCCC"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.70.10:FF:000332">
        <property type="entry name" value="Cathepsin L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025661">
        <property type="entry name" value="Pept_asp_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000169">
        <property type="entry name" value="Pept_cys_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025660">
        <property type="entry name" value="Pept_his_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013201">
        <property type="entry name" value="Prot_inhib_I29"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08246">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00848">
        <property type="entry name" value="Inhibitor_I29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00640">
        <property type="entry name" value="THIOL_PROTEASE_ASN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00139">
        <property type="entry name" value="THIOL_PROTEASE_CYS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00639">
        <property type="entry name" value="THIOL_PROTEASE_HIS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="4" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="Cathepsin propeptide inhibitor" evidence="7">
        <location>
            <begin position="86"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="6">
        <location>
            <begin position="176"/>
            <end position="396"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90067.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="401" mass="45395" checksum="87440FE5B2A61B73" modified="2007-04-03" version="1">MDIGNNVEEHQEYISGPYIALINGTNQQREPNKKLKNIIIATLIAIFIVLVVTVSLYITNNTSDKIDDFVPGDYVDPATREYRKSFEEFKKKYHKVYSSMEEENQRFEIYKQNMNFIKTTNSQGFSYVLEMNEFGDLSKEEFMARFTGYIKDSKDDERVFKSSRVSASESEEEFVPPNSINWVEAGCVNPIRNQKNCGSCWAFSAVAALEGATCAQTNRGLPSLSEQQFVDCSKQNGNFGCDGGTMGLAFQYAIKNKYLCTNDDYPYFAEEKTCMDSFCENYIEIPVKAYKYVFPRNINALKTALAKYGPISVAIQADQTPFQFYKSGVFDAPCGTKVNHGVVLVGYDMDEDTNKEYWLVRNSWGEAWGEKGYIKLALHSGKKGTCGILVEPVYPVINQSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWL9</accession>
    <name>Q5CWL9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Palmitoyltransferase</fullName>
            <ecNumber evidence="7">2.3.1.225</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_4540</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-cysteinyl-[protein] + hexadecanoyl-CoA = S-hexadecanoyl-L-cysteinyl-[protein] + CoA</text>
            <dbReference type="Rhea" id="RHEA:36683"/>
            <dbReference type="Rhea" id="RHEA-COMP:10131"/>
            <dbReference type="Rhea" id="RHEA-COMP:11032"/>
            <dbReference type="ChEBI" id="CHEBI:29950"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57379"/>
            <dbReference type="ChEBI" id="CHEBI:74151"/>
            <dbReference type="EC" id="2.3.1.225"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="domain">
        <text evidence="7">The DHHC domain is required for palmitoyltransferase activity.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DHHC palmitoyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.225" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627785.1">
        <property type="nucleotide sequence ID" value="XM_627785.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWL9"/>
    <dbReference type="SMR" id="Q5CWL9"/>
    <dbReference type="STRING" id="353152.Q5CWL9"/>
    <dbReference type="GeneID" id="3375792"/>
    <dbReference type="KEGG" id="cpv:cgd6_4540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4540"/>
    <dbReference type="InParanoid" id="Q5CWL9"/>
    <dbReference type="OMA" id="VAVQTFH"/>
    <dbReference type="OrthoDB" id="9909019at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019706">
        <property type="term" value="F:protein-cysteine S-palmitoyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001594">
        <property type="entry name" value="Palmitoyltrfase_DHHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039859">
        <property type="entry name" value="PFA4/ZDH16/20/ERF2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12246">
        <property type="entry name" value="PALMITOYLTRANSFERASE ZDHHC16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01529">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50216">
        <property type="entry name" value="DHHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 7 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="47"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="144"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="188"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Palmitoyltransferase DHHC" evidence="8">
        <location>
            <begin position="92"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU079119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF01529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="323" mass="37201" checksum="8571F203D47A86EC" modified="2007-04-03" version="1">MNSGGLPASYSARKRKNGACFLLFIMTMIALLYACYFVILLQPLFEIYYIGASVSAAFHLVFALFLISFYQCTNTEPGRVPAKWGFRVGDESKRRRYCKVCQVWKPDRTHHCSECGKCVLNMDHHCPWINNCVGFYNRKFFIQLLIYAQLSLLFLFVQGTMFLVEQYITLWPYNHGTDPTPLGRSIEAIKLTSIIVMLVFVTPLLLALFPFSRLHIGFIVRNLTTIESLSPQSPEYGRYDLGPERNIQQAFGHNPMQWFCPFNTKSSRPVGDGVRWPVRCPEVDDLEMGQIPIYSHQNINDRNTYHGHQNLSPYNNSGVYHQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWS0</accession>
    <name>Q5CWS0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90003.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627734.1">
        <property type="nucleotide sequence ID" value="XM_627734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWS0"/>
    <dbReference type="GeneID" id="3375748"/>
    <dbReference type="KEGG" id="cpv:cgd6_3980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3980"/>
    <dbReference type="InParanoid" id="Q5CWS0"/>
    <dbReference type="OMA" id="NPFETMK"/>
    <dbReference type="OrthoDB" id="342445at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="137"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="64"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="137"/>
            <end position="146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90003.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="157" mass="18400" checksum="F64C727E17D2D470" modified="2007-04-03" version="1">MVDNLGKPLTRGQRKRRLVLERVKRKQDLTSYLLREKQLENAKNIKKKCYNLNNLKHEIINASEVHKEEASSQEKGKKNKLSRKKIQNIKKSSIEFYKDVLQHPDFNEIGSIKSMLMEKFENNDHGNDQIMDIVKKSNKGKQKVNKSVKVAKSIKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWX6</accession>
    <name>Q5CWX6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Membrane associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_3330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90151.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627678.1">
        <property type="nucleotide sequence ID" value="XM_627678.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWX6"/>
    <dbReference type="STRING" id="353152.Q5CWX6"/>
    <dbReference type="TCDB" id="4.E.1.1.6">
        <property type="family name" value="the vacuolar (acidocalcisome) polyphosphate polymerase/channel (v-pppc) family"/>
    </dbReference>
    <dbReference type="GeneID" id="3375896"/>
    <dbReference type="KEGG" id="cpv:cgd6_3330"/>
    <dbReference type="InParanoid" id="Q5CWX6"/>
    <dbReference type="OMA" id="NEHYNEH"/>
    <dbReference type="OrthoDB" id="2243669at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14447">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003807">
        <property type="entry name" value="DUF202"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02656">
        <property type="entry name" value="DUF202"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03105">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="25"/>
            <end position="45"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="940"/>
            <end position="960"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="967"/>
            <end position="987"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="1007"/>
            <end position="1029"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="8">
        <location>
            <begin position="43"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="605"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="605"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90151.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1078" mass="123265" checksum="CC4C0D53CC5FDACA" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWY0</accession>
    <name>Q5CWY0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="14">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd6_3290</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Forms the polymerase active center together with the second largest subunit. A single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol III. A bridging helix emanates from RPC1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol III by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12 14">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="14"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627674.1">
        <property type="nucleotide sequence ID" value="XM_627674.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CWY0">
        <property type="interactions" value="337"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWY0"/>
    <dbReference type="GeneID" id="3375700"/>
    <dbReference type="KEGG" id="cpv:cgd6_3290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3290"/>
    <dbReference type="InParanoid" id="Q5CWY0"/>
    <dbReference type="OMA" id="NMNSIHN"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02736">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02583">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.150.390:FF:000004">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.274.100:FF:000008">
        <property type="entry name" value="DNA-directed RNA polymerase subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.390">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035698">
        <property type="entry name" value="RNAP_III_Rpc1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035697">
        <property type="entry name" value="RNAP_III_RPC1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015700">
        <property type="entry name" value="RPC1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006336">
        <property type="entry name" value="PRK08566.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48446:SF1">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT BETA' N-TERMINAL SECTION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 14 18" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10 14" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="17">
        <location>
            <begin position="242"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="953"/>
            <end position="986"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="15">
        <location>
            <begin position="1055"/>
            <end position="1131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="974"/>
            <end position="983"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011206"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00058108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAK89955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1871" mass="212280" checksum="1281EF48F2ABBEB5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX09</accession>
    <name>Q5CX09_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">tyrosine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Tyrosyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd6_2970</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>tRNA(Tyr) + L-tyrosine + ATP = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:10220"/>
            <dbReference type="Rhea" id="RHEA-COMP:9706"/>
            <dbReference type="Rhea" id="RHEA-COMP:9707"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:58315"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78536"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the class-I aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.1" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89929.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627645.1">
        <property type="nucleotide sequence ID" value="XM_627645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX09"/>
    <dbReference type="FunCoup" id="Q5CX09">
        <property type="interactions" value="376"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX09"/>
    <dbReference type="GeneID" id="3375674"/>
    <dbReference type="KEGG" id="cpv:cgd6_2970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2970"/>
    <dbReference type="InParanoid" id="Q5CX09"/>
    <dbReference type="OMA" id="RKIHMLA"/>
    <dbReference type="OrthoDB" id="197206at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004831">
        <property type="term" value="F:tyrosine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006437">
        <property type="term" value="P:tyrosyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000085">
        <property type="entry name" value="Tyrosine--tRNA ligase 1 cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000103">
        <property type="entry name" value="tyrosine--tRNA ligase 1, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002305">
        <property type="entry name" value="aa-tRNA-synth_Ic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023617">
        <property type="entry name" value="Tyr-tRNA-ligase_arc/euk-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050489">
        <property type="entry name" value="Tyr-tRNA_synthase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006330">
        <property type="entry name" value="PRK08560.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264:SF4">
        <property type="entry name" value="TYROSINE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46264">
        <property type="entry name" value="TYROSINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00579">
        <property type="entry name" value="tRNA-synt_1b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006588">
        <property type="entry name" value="TyrRS_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13 14" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="8 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="7 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 13" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00033323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048248"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU363036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK89929.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="376" mass="42941" checksum="350ACAD220CA8637" modified="2005-04-12" version="1">MSSNSCTETIPKYILKGSEEPLKRSKLTLEERHKLCLSVGEECIQEAELLELLKRKEHPICYDGFEPSGRMHIAQCILKTINVNKLTECGCVFVFYVADWFALLNNKMGGDLEKIKIVGEYFVHIWKAAGMDMTNVRFVWASDFINGEDSNEYWLRVFDISRKFNITRIKRCCQIMGRQENDEQPCASVFYPCMQCADIFQLKADICQLGMDQRKVNMLAREYCDAAGIKHKPVILSHKMLPGLLEGQEKMSKSDTSSAIFVEDTPEAVVKKIKKAFCPPGIIEGNPCIEYINTLVFPKFGHFHVSRKEEYGGDITFTNKEDFHKAYLSGDLHPGDLKKGLSDALNLMLQPIRDHFNTDPRAKELLQLVQSFKVTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX41</accession>
    <name>Q5CX41_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89902.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627613.1">
        <property type="nucleotide sequence ID" value="XM_627613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX41"/>
    <dbReference type="STRING" id="353152.Q5CX41"/>
    <dbReference type="GeneID" id="3376142"/>
    <dbReference type="KEGG" id="cpv:cgd6_2600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2600"/>
    <dbReference type="InParanoid" id="Q5CX41"/>
    <dbReference type="OrthoDB" id="340780at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="289"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="648"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="109"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="613"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="648"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="667"/>
            <end position="692"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89902.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="692" mass="75117" checksum="1D46D0B576E8B33C" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX94</accession>
    <name>Q5CX94_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89859.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627560.1">
        <property type="nucleotide sequence ID" value="XM_627560.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX94"/>
    <dbReference type="GeneID" id="3376071"/>
    <dbReference type="KEGG" id="cpv:cgd6_1990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1990"/>
    <dbReference type="InParanoid" id="Q5CX94"/>
    <dbReference type="OMA" id="RSSKMNI"/>
    <dbReference type="OrthoDB" id="339587at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89859.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1011" mass="112935" checksum="778735A901E7A5DF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXF0</accession>
    <name>Q5CXF0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">3CCCH domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_1330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90123.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627504.1">
        <property type="nucleotide sequence ID" value="XM_627504.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXF0"/>
    <dbReference type="STRING" id="353152.Q5CXF0"/>
    <dbReference type="GeneID" id="3375868"/>
    <dbReference type="KEGG" id="cpv:cgd6_1330"/>
    <dbReference type="InParanoid" id="Q5CXF0"/>
    <dbReference type="OMA" id="WFAVGRC"/>
    <dbReference type="OrthoDB" id="415459at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045877">
        <property type="entry name" value="ZFP36-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547">
        <property type="entry name" value="CCCH ZINC FINGER/TIS11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12547:SF18">
        <property type="entry name" value="PROTEIN TIS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14608">
        <property type="entry name" value="zf-CCCH_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18345">
        <property type="entry name" value="zf_CCCH_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="6">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="46"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="5">
        <location>
            <begin position="81"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90123.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="337" mass="39078" checksum="B57C7815B4D34D56" modified="2005-04-12" version="1" fragment="single">KRHLKKIMAQFYKTKKCPWFAVGRCRMDKECNWAHSIDELRPSVDLTRTKLCEIQLKEGICRNPQCRYAHSRKELRATSDLFKTSLCVYWIKGSCVVGDSCRYAHGIEELRSKPQKGEFIPLDVETLPVPIQKITNQRQDLSMNFDGKNIFNDSRLYHPYNAVSTTSSLGSINKFGSDSIDKSFEGMPSLVSSLFNTESSKVGQHLSERNLCSEETFHLSNQFTPLSLLDIPLVWRDKSFGHKNNHINNLHESLCNIGSEYQHFNQFDNQTRINNMIFHRSQINNKRHHNNEFDGRIESVQMIKRSYPESIEEMYSYTPSTASSIRDKMNLHNLEVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXJ1</accession>
    <name>Q5CXJ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89777.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627463.1">
        <property type="nucleotide sequence ID" value="XM_627463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXJ1"/>
    <dbReference type="GeneID" id="3376087"/>
    <dbReference type="KEGG" id="cpv:cgd6_890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_890"/>
    <dbReference type="InParanoid" id="Q5CXJ1"/>
    <dbReference type="OMA" id="THEYFKV"/>
    <dbReference type="OrthoDB" id="338646at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="19"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="19"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89777.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="171" mass="20035" checksum="0FA7E5429988B7F3" modified="2007-04-03" version="1">MLSTPPQLSQIRRVKFQPTLSPIAQSPLSENVSKSSPKIEKEMKNIGTQTDLVELKAISKVCENRIEIKTKEDSIDETENQYELDEIKSINTGEIMINYNKIKENQKQRMNQFEANPEKDIQTKKYSLRENSRSITYTVPSLRVKLRRDTEKPEYNPFKTHNYFKPKKILN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXP5</accession>
    <name>Q5CXP5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RecQ mediated genome instability protein 1 OB-fold domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_5420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628685.1">
        <property type="nucleotide sequence ID" value="XM_628683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXP5"/>
    <dbReference type="STRING" id="353152.Q5CXP5"/>
    <dbReference type="GeneID" id="3372150"/>
    <dbReference type="KEGG" id="cpv:cgd7_5420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5420"/>
    <dbReference type="InParanoid" id="Q5CXP5"/>
    <dbReference type="OMA" id="HCNEENI"/>
    <dbReference type="OrthoDB" id="341511at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.770">
        <property type="entry name" value="RecQ-mediated genome instability protein Rmi1, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042470">
        <property type="entry name" value="RMI1_N_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013894">
        <property type="entry name" value="RMI1_OB"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08585">
        <property type="entry name" value="RMI1_N_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01161">
        <property type="entry name" value="DUF1767"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecQ mediated genome instability protein 1 OB-fold" evidence="1">
        <location>
            <begin position="58"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="523" mass="59943" checksum="CCA4CFA92E8CB3FC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXR2</accession>
    <name>Q5CXR2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Methyltransfer with N-terminal ankyrin repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_5250</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90657.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628668.1">
        <property type="nucleotide sequence ID" value="XM_628666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXR2"/>
    <dbReference type="STRING" id="353152.Q5CXR2"/>
    <dbReference type="GeneID" id="3371754"/>
    <dbReference type="KEGG" id="cpv:cgd7_5250"/>
    <dbReference type="InParanoid" id="Q5CXR2"/>
    <dbReference type="OMA" id="IQNKHYE"/>
    <dbReference type="OrthoDB" id="46564at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019410">
        <property type="entry name" value="Methyltransf_16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14614">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10294">
        <property type="entry name" value="Methyltransf_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="ANK" evidence="1">
        <location>
            <begin position="56"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90657.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="447" mass="50315" checksum="B55ED71D3F054986" modified="2005-04-12" version="1" fragment="single">AEEYTYCSEVVDIRMEGLTVKEISDEMTECARYGELDDMKYILDNYKIDIDYQDDNGNTALHKSSANGHLDVVCELLNRGASINKQNNNGNSPLHWATTNKKKEVIIKLLSDRRKVEEGGADVLLKNSLNKSVLTEVFNMNDEDILKLALEHPSADKLEQEHSGSVKFDEDHGELNSDSNVTISQEVIHNLTFTSDDVDKLGARPIIKCRELALMGVKEVFDQNPQNDTTGVHLWSSSIVASYWIANLVRNENIFAGKRVIELGCGCGLMSLAAAIYSRYFFDSQPAKLFLTDVSRLSLENAGINIKLNSSLLGSHQNFIQAKYLNWFDQESFRSLDPENPEIMGSFDIILGSDLVYNSDMEIQLSQVISGLLAIQGTFYYVHRHDRLCASKFKQALESTGLACQEIQSPEDYTRNPLYGQSQQLADSLFNELSSQSEFYLLIARRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXV6</accession>
    <name>Q5CXV6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">DNA-directed RNA polymerase subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_4770</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628624.1">
        <property type="nucleotide sequence ID" value="XM_628622.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXV6"/>
    <dbReference type="FunCoup" id="Q5CXV6">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXV6"/>
    <dbReference type="GeneID" id="3372218"/>
    <dbReference type="KEGG" id="cpv:cgd7_4770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4770"/>
    <dbReference type="InParanoid" id="Q5CXV6"/>
    <dbReference type="OMA" id="VNQKRIT"/>
    <dbReference type="OrthoDB" id="259769at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006360">
        <property type="term" value="P:transcription by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.940.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020708">
        <property type="entry name" value="DNA-dir_RNA_polK_14-18kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006110">
        <property type="entry name" value="Pol_omega/Rpo6/RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028363">
        <property type="entry name" value="RPB6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036161">
        <property type="entry name" value="RPB6/omega-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006111">
        <property type="entry name" value="Rpo6/Rpb6"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF002208">
        <property type="entry name" value="PRK01099.1-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE SUBUNIT K"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47227:SF5">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01192">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF500154">
        <property type="entry name" value="RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000778">
        <property type="entry name" value="RpoK/RPB6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01409">
        <property type="entry name" value="RNA_pol_Rpb6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63562">
        <property type="entry name" value="RPB6/omega subunit-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01111">
        <property type="entry name" value="RNA_POL_K_14KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025773"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="129" mass="14976" checksum="A14758CB98757E9F" modified="2005-04-12" version="1">MNDYDESGGNYDEEEEYMEEELIEEEIEGDENIEILTEDAVHSRYDGKPNEGPRITTPYMTKFEKARIIGTRALQISMNAPVAIPLDGETDPLLIAEKELYTKKIPFVIRRYLPNGNYEDWKIDELILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY07</accession>
    <name>Q5CY07_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Ring domain protein, possible 4 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_4170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628573.1">
        <property type="nucleotide sequence ID" value="XM_628571.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY07"/>
    <dbReference type="STRING" id="353152.Q5CY07"/>
    <dbReference type="GeneID" id="3372075"/>
    <dbReference type="KEGG" id="cpv:cgd7_4170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4170"/>
    <dbReference type="InParanoid" id="Q5CY07"/>
    <dbReference type="OMA" id="ICSICMM"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052788">
        <property type="entry name" value="RING-type_E3_ligase_ATL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45798:SF97">
        <property type="entry name" value="ALCOHOL-SENSITIVE RING FINGER PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45798">
        <property type="entry name" value="RING-H2 FINGER PROTEIN ATL61-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="87"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="157"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="197"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="312"/>
            <end position="355"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="368" mass="42362" checksum="2BF83B0E93115366" modified="2005-04-12" version="1">MSFYLQNENTGVDEELGISWTVHLEPAEEIEDVINLSNFRRLEDPEAQANITFANAFSAEPCEGSTTHNNNQEYQVITENGEADNRIMLAIAVNILIMVTIFGIFTTILVQLVRDWGNKCDRQLKTWCIVWLSRFLLTSVIRSMTIIISKVYQTQSPFILVLIVNVLHIFGIAWWFYGINLIYSNPPELTCRKNYSIALFLFWFQFVQIFVPILLPIILCVLILYILHRNGIRTEKKNVPEELLCKIQAIPFVEHIRNLNNSAHVTIFDENQSVVETQHYPGSKSETRLNVMQDDSTPSFNKEKSITISKSCPICVQEIEDDATIRVLPCDSRHIFHLECIDGWFKQNCVCPICRSDIVQILNETQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY27</accession>
    <name>Q5CY27_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Multiple myeloma tumor-associated protein 2-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3920</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628553.1">
        <property type="nucleotide sequence ID" value="XM_628551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY27"/>
    <dbReference type="GeneID" id="3372139"/>
    <dbReference type="KEGG" id="cpv:cgd7_3920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3920"/>
    <dbReference type="InParanoid" id="Q5CY27"/>
    <dbReference type="OrthoDB" id="5390672at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019315">
        <property type="entry name" value="MMTA2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039207">
        <property type="entry name" value="MMTAG2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580:SF0">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14580">
        <property type="entry name" value="MULTIPLE MYELOMA TUMOR-ASSOCIATED PROTEIN 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10159">
        <property type="entry name" value="MMtag"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Multiple myeloma tumor-associated protein 2-like N-terminal" evidence="1">
        <location>
            <begin position="14"/>
            <end position="96"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF10159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="167" mass="19363" checksum="B8932CD23413ECEA" modified="2005-04-12" version="1">MDLSDSFDIAKQSGVRGGAEQFNWDSLRSIPRKEREHYLGHSLHYNRSRGRGRFSRNDWFSKVHKSKPEKCTSSEFQNERERIMNKEREIMNKLLGIPDNSEVSEYIKNEVSESDKNAGTHIQESQEMRIISCIGRGSKGGIQVNKNQICNEQRKAKRRSFSRSLSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY70</accession>
    <name>Q5CY70_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3460</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628510.1">
        <property type="nucleotide sequence ID" value="XM_628508.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY70"/>
    <dbReference type="GeneID" id="3372102"/>
    <dbReference type="KEGG" id="cpv:cgd7_3460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3460"/>
    <dbReference type="InParanoid" id="Q5CY70"/>
    <dbReference type="OrthoDB" id="337639at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="290" mass="33542" checksum="A9E8B9BBB754A91A" modified="2005-04-12" version="1">MSNQEKNKFALQIDTHWGDPLYVIYKNSSGFILNFETWKYAKSRSKSIGILLEMSDSNGLNKYPFCLTILSSGKLINTLSNSRIFLDKFIKLLISSPMVNELNKFPLGYGQIVFFDELLFLVERGSLLLFSWSRSRLEWVQTPILYLFDAFIRNEEQFKLNNYISYSRMKRSGYKFKTSSNENKVIVQDNIHSDTKFLKCIDEAEHVQYGTAIKQTIVLSSINSNLESYLITNLESKPKDGEKNDLFFASKQPHDTFLIGNNITRSNNNFIVSIISINSETRLKASIYKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="126" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYC1</accession>
    <name>Q5CYC1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA replication licensing factor MCM5</fullName>
            <ecNumber evidence="5">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_2920</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="5"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628459.1">
        <property type="nucleotide sequence ID" value="XM_628457.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYC1"/>
    <dbReference type="FunCoup" id="Q5CYC1">
        <property type="interactions" value="421"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYC1"/>
    <dbReference type="GeneID" id="3372277"/>
    <dbReference type="KEGG" id="cpv:cgd7_2920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2920"/>
    <dbReference type="InParanoid" id="Q5CYC1"/>
    <dbReference type="OMA" id="ITYCKTR"/>
    <dbReference type="OrthoDB" id="10036721at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017116">
        <property type="term" value="F:single-stranded DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000826">
        <property type="entry name" value="Replicative DNA helicase Mcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008048">
        <property type="entry name" value="MCM5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF42">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01661">
        <property type="entry name" value="MCMPROTEIN5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0235">DNA replication</keyword>
    <keyword evidence="3 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0347">Helicase</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="6">
        <location>
            <begin position="387"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU368063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="791" mass="88302" checksum="7E8692F4A70E89F3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYD2</accession>
    <name>Q5CYD2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Regena domain protein (CCR-Not complex protein subunit 3), putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_2790</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CNOT2/3/5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628448.1">
        <property type="nucleotide sequence ID" value="XM_628446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYD2"/>
    <dbReference type="FunCoup" id="Q5CYD2">
        <property type="interactions" value="17"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYD2"/>
    <dbReference type="GeneID" id="3372265"/>
    <dbReference type="KEGG" id="cpv:cgd7_2790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2790"/>
    <dbReference type="InParanoid" id="Q5CYD2"/>
    <dbReference type="OrthoDB" id="293823at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030015">
        <property type="term" value="C:CCR4-NOT core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1020">
        <property type="entry name" value="CCR4-NOT complex subunit 2/3/5, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038635">
        <property type="entry name" value="CCR4-NOT_su2/3/5_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040168">
        <property type="entry name" value="Not2/3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007282">
        <property type="entry name" value="NOT2/3/5_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23326">
        <property type="entry name" value="CCR4 NOT-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04153">
        <property type="entry name" value="NOT2_3_5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="NOT2/NOT3/NOT5 C-terminal" evidence="5">
        <location>
            <begin position="231"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="30"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04153"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="394" mass="46096" checksum="70F1A81C3D4F9400" modified="2005-04-12" version="1">MADSELNLICSIFSKCESDLKAIVSIVNILSKNKYEVNKFETEIREIKEKLHIVEKKIVESRIVSSNQTDFVSEKYILEKCHESLQSLKGSIVNFKEIKMNNDHSQGDKKLQINDFESKSVGDLLNDEFSELRIDNEVKLSQINADNYIKDSFSPEKLNENDIYTRERIVKPGNNTEIPIENTDEYKHSIGFRMDVSKHLNTDILDNSFNNKLEIQDSIGRHIQYTPRMVWHNPRSDFPSRPLEKLANTSFFDKLALDTLFFIFYFQQGTFQQFLSIQELKRKKWQFHKKCFAWFYKRSDSKITTEDAEVADYIYFDFEKDWCQKIKNDFAFEYIHLDDTPIVINKNNESNACYNSKACADKDQISFNSDISENIFNADGAINDHCTINNPSNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYM6</accession>
    <name>Q5CYM6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Ubiquitin-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_1770</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90218.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628354.1">
        <property type="nucleotide sequence ID" value="XM_628352.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYM6"/>
    <dbReference type="STRING" id="353152.Q5CYM6"/>
    <dbReference type="GeneID" id="3371738"/>
    <dbReference type="KEGG" id="cpv:cgd7_1770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1770"/>
    <dbReference type="InParanoid" id="Q5CYM6"/>
    <dbReference type="OMA" id="DPMSLCD"/>
    <dbReference type="OrthoDB" id="328608at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90218.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="106" mass="11782" checksum="CE33D1D99DA1A17B" modified="2005-04-12" version="1">MCEKKGLSLPPKNDELRREENESLKGESLTLRLNFKDLDGIVEELSVNSSTEVGFVKLLIAKSKNVQAKDIRIFHNGKNMINPMSLCDHPGVSPPSVDVDVYLNSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYY5</accession>
    <name>Q5CYY5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">GPI transamidase subunit PIG-U</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the PIGU family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628245.1">
        <property type="nucleotide sequence ID" value="XM_628243.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYY5"/>
    <dbReference type="STRING" id="353152.Q5CYY5"/>
    <dbReference type="GeneID" id="3371913"/>
    <dbReference type="KEGG" id="cpv:cgd7_540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_540"/>
    <dbReference type="InParanoid" id="Q5CYY5"/>
    <dbReference type="OMA" id="FTFIIHI"/>
    <dbReference type="OrthoDB" id="342753at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009600">
        <property type="entry name" value="PIG-U"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121">
        <property type="entry name" value="GPI TRANSAMIDASE COMPONENT PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13121:SF0">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL GLYCAN ANCHOR BIOSYNTHESIS CLASS U PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06728">
        <property type="entry name" value="PIG-U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="5"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="132"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="253"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="359"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="395"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="427"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="12">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="466" mass="54479" checksum="EA20636A8C26E21C" modified="2005-04-12" version="1">MKKELVFLIIISILIKLSFFILVEHDLEDYTNGFFGILGQNFGEVLEFCALKEYGISTYYESKRVNFPAVFMELISGLCSSINSKNGLIFPFLAINLIQILQGILIYSYLIKSYPILSTISKTIIEKNNYELCVNMLVGIFWINPISIYTSSLLSFGIEFELFLQLLLLWISIDSSHKFRALLPIISGINVYYSPTVSISLIPSTLTLFLSGNQHFLKFNTCPQLFDNFKMHFKHFWINFLSNYFNFRNILKIILFFTSFTITFLSLHIFSFIIINHQNSHHILTFKEYFYTFIVQNFTLLENKDLNPYLNIYWFLMYCIASEFRLYFQIILGSCLIIYAFILNISLEKIPFKALQSQLLLCFVFKSNPTFINYLLIFFFILFDSVTLFESKSGFLASFSFVTWMICIPSAFLIRPIWILENSLDSNFYYFLTLAGNFSIIIFIGEWIKSLFNNLVKYSPNPDKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ08</accession>
    <name>Q5CZ08_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">CpCCP2 extracellular protein with a signal peptide, ricin, discoidin, NEC, LCCL, 2 levanase and an apicomplexan-specific cysteine-rich repeat (ApicA repeat)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90522.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628222.1">
        <property type="nucleotide sequence ID" value="XM_628220.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CZ08">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CZ08"/>
    <dbReference type="GeneID" id="3372042"/>
    <dbReference type="KEGG" id="cpv:cgd7_300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_300"/>
    <dbReference type="InParanoid" id="Q5CZ08"/>
    <dbReference type="OMA" id="CQMCCQS"/>
    <dbReference type="OrthoDB" id="414826at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.560">
        <property type="entry name" value="Exo-inulinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.130.20">
        <property type="entry name" value="LCCL-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051957">
        <property type="entry name" value="CRISP-LCCL_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036056">
        <property type="entry name" value="Fibrinogen-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004043">
        <property type="entry name" value="LCCL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036609">
        <property type="entry name" value="LCCL_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331:SF1">
        <property type="entry name" value="CYSTEINE RICH SECRETORY PROTEIN LCCL DOMAIN CONTAINING 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31331">
        <property type="entry name" value="LCCL DOMAIN PROTEIN (AFU_ORTHOLOGUE AFUA_5G08630)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03815">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00603">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56496">
        <property type="entry name" value="Fibrinogen C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69848">
        <property type="entry name" value="LCCL domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50820">
        <property type="entry name" value="LCCL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255110" evidence="1">
        <location>
            <begin position="24"/>
            <end position="1674"/>
        </location>
    </feature>
    <feature type="domain" description="LCCL" evidence="2">
        <location>
            <begin position="780"/>
            <end position="873"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90522.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1674" mass="184530" checksum="36150188EC298864" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ28</accession>
    <name>Q5CZ28_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_50</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628202.1">
        <property type="nucleotide sequence ID" value="XM_628200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ28"/>
    <dbReference type="GeneID" id="3372028"/>
    <dbReference type="KEGG" id="cpv:cgd7_50"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_50"/>
    <dbReference type="InParanoid" id="Q5CZ28"/>
    <dbReference type="OMA" id="YITYRQQ"/>
    <dbReference type="OrthoDB" id="342735at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="126" mass="14115" checksum="3DBB73EE0D209903" modified="2005-04-12" version="1">MAQQYIYNTDYINEINEEVYKEIGISHELEQFARKGIIPNKNNNLSIHNNTTYVSRPIKSVTSENAANGKLNSVAGFGVVALTLLIIYLLNKILFWFIVISIFAFCISVATRSLGNIEASGKKLPF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ59</accession>
    <name>A3FQ59_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd2_1010</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51368.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388195.1">
        <property type="nucleotide sequence ID" value="XM_001388158.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ59"/>
    <dbReference type="FunCoup" id="A3FQ59">
        <property type="interactions" value="398"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ59"/>
    <dbReference type="GeneID" id="3373424"/>
    <dbReference type="KEGG" id="cpv:cgd2_1010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1010"/>
    <dbReference type="InParanoid" id="A3FQ59"/>
    <dbReference type="OMA" id="STMPKFE"/>
    <dbReference type="OrthoDB" id="196131at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17966">
        <property type="entry name" value="DEADc_DDX5_DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000008">
        <property type="entry name" value="ATP-dependent RNA helicase RhlB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000079">
        <property type="entry name" value="probable ATP-dependent RNA helicase DDX17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0347">Helicase</keyword>
    <keyword evidence="3 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="199"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="388"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="550"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="168"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51368.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="586" mass="65699" checksum="3317A91B82CC7DE2" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ60</accession>
    <name>A3FQ60_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mitochondrial carrier protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd2_1030</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51369.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388196.1">
        <property type="nucleotide sequence ID" value="XM_001388159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ60"/>
    <dbReference type="STRING" id="353152.A3FQ60"/>
    <dbReference type="GeneID" id="3373423"/>
    <dbReference type="KEGG" id="cpv:cgd2_1030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1030"/>
    <dbReference type="InParanoid" id="A3FQ60"/>
    <dbReference type="OMA" id="MYNSQHQ"/>
    <dbReference type="OrthoDB" id="43906at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031966">
        <property type="term" value="C:mitochondrial membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015093">
        <property type="term" value="F:ferrous iron transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048250">
        <property type="term" value="P:iron import into the mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758:SF4">
        <property type="entry name" value="MITOFERRIN-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45758">
        <property type="entry name" value="MITOFERRIN-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 9" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="222"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="15"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="127"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="219"/>
            <end position="313"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51369.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="314" mass="34840" checksum="2BAF23900B46FB13" modified="2007-04-03" version="1">MEKDIEDWEIWKGDIPFWKHSLAGSIAGVMEHSCFFPLDTIKTCLQSGKVDGLTGNRGMIAFIRSNGARALFRGFPAVVFGNVPAHASMFTTYEFSKRLMSKITKKLEKRAESKSSLLHDANTSIFNSVVSPAICGGLSTISHDIIATPLDVIKQRLQVGSYKGMADCIITMFKREGIRSFYRSLPITLFMNIPQTGLFVLLNENLKSLFGKNKDDLLKQNTFNFVIAGISGGTAAFITNPLDLIKTKLQTQACHVSQKETLRVVYPSVKKAFIDTLRKQGIRGMYSGALARSLLIAPSYALCWGTYETVKNFL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ77</accession>
    <name>A3FQ77_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-glucuronic acid decarboxylase 1</fullName>
            <ecNumber evidence="5">4.1.1.35</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="16">UDP-glucuronate decarboxylase 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">cgd2_1900</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>UDP-alpha-D-glucuronate + H(+) = UDP-alpha-D-xylose + CO2</text>
            <dbReference type="Rhea" id="RHEA:23916"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16526"/>
            <dbReference type="ChEBI" id="CHEBI:57632"/>
            <dbReference type="ChEBI" id="CHEBI:58052"/>
            <dbReference type="EC" id="4.1.1.35"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="17">
            <dbReference type="Rhea" id="RHEA:23917"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>NAD(+)</name>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Nucleotide-sugar biosynthesis; UDP-alpha-D-xylose biosynthesis; UDP-alpha-D-xylose from UDP-alpha-D-glucuronate: step 1/1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
            <location evidence="2">Golgi stack membrane</location>
            <topology evidence="2">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.1.1.35" evidence="5"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51386.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388213.1">
        <property type="nucleotide sequence ID" value="XM_001388176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ77"/>
    <dbReference type="FunCoup" id="A3FQ77">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ77"/>
    <dbReference type="GeneID" id="3373439"/>
    <dbReference type="KEGG" id="cpv:cgd2_1900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1900"/>
    <dbReference type="InParanoid" id="A3FQ77"/>
    <dbReference type="OMA" id="KYPKVKY"/>
    <dbReference type="OrthoDB" id="331544at2759"/>
    <dbReference type="UniPathway" id="UPA00796">
        <property type="reaction ID" value="UER00771"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032580">
        <property type="term" value="C:Golgi cisterna membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070403">
        <property type="term" value="F:NAD+ binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048040">
        <property type="term" value="F:UDP-glucuronate decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042732">
        <property type="term" value="P:D-xylose metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033320">
        <property type="term" value="P:UDP-D-xylose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05230">
        <property type="entry name" value="UGD_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000065">
        <property type="entry name" value="UDP-glucuronic acid decarboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016040">
        <property type="entry name" value="NAD(P)-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044516">
        <property type="entry name" value="UXS-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078:SF6">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43078">
        <property type="entry name" value="UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16363">
        <property type="entry name" value="GDP_Man_Dehyd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0210">Decarboxylase</keyword>
    <keyword evidence="14" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="12" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="15" id="KW-0456">Lyase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-0520">NAD</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="NAD(P)-binding" evidence="18">
        <location>
            <begin position="7"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001911"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007505"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00018816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022793"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00031585"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00049410"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF16363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAZ51386.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="335" mass="38110" checksum="43B52439C6C5503F" modified="2007-04-03" version="1">MSDITVLVTGASGFIGSHLVEYLLSKGYYVLALDNFFSGDVINIGQCRENPRLEIIRHDIIDSIKLEVKEIYHLACPASPIHYQKDPIYTLKTCFIGTMNILGLAKRTNSKVVFASTSEIYGDPLVHPQNESYYGNVNTVGTRSCYDEGKRIAETLCMEYYRNHGVDVRIARIFNTYGPKMLFNDGRVVSNFILSSLLNQELPIYGDGTQTRSFCYITDMVDGLYKLMKLDREKILDNMPINLGNPNEISILELGEIIRELVDPNLKISHRKFPMDDPKKRQPDISRAIRILNWKPTVDIKTGIKETIKDFKVRLENNKSVEVLHQKEAKPILSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ94</accession>
    <name>A3FQ94_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388230.1">
        <property type="nucleotide sequence ID" value="XM_001388193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ94"/>
    <dbReference type="STRING" id="353152.A3FQ94"/>
    <dbReference type="GeneID" id="3373543"/>
    <dbReference type="KEGG" id="cpv:cgd2_3140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3140"/>
    <dbReference type="InParanoid" id="A3FQ94"/>
    <dbReference type="OMA" id="TSERMVN"/>
    <dbReference type="OrthoDB" id="10468695at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="250"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="500"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="663"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="702"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="500"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="533"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="663"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="674"/>
            <end position="685"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="777" mass="85519" checksum="EFC327C39FEE13C4" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQF8</accession>
    <name>A3FQF8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Carboxylesterase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_3290</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388180.1">
        <property type="nucleotide sequence ID" value="XM_001388143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQF8"/>
    <dbReference type="STRING" id="353152.A3FQF8"/>
    <dbReference type="GeneID" id="3371389"/>
    <dbReference type="KEGG" id="cpv:cgd1_3290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3290"/>
    <dbReference type="InParanoid" id="A3FQF8"/>
    <dbReference type="OrthoDB" id="2418081at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052689">
        <property type="term" value="F:carboxylic ester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050565">
        <property type="entry name" value="LYPA1-2/EST-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655:SF17">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10655">
        <property type="entry name" value="LYSOPHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="5">
        <location>
            <begin position="58"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="381"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="447"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="540"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="540"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="601"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="614"/>
            <end position="624"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="729" mass="83368" checksum="093BAA25DA4C9135" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQH4</accession>
    <name>A3FQH4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">C2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51280.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388258.1">
        <property type="nucleotide sequence ID" value="XM_001388221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQH4"/>
    <dbReference type="FunCoup" id="A3FQH4">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="3373368"/>
    <dbReference type="KEGG" id="cpv:cgd5_780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_780"/>
    <dbReference type="InParanoid" id="A3FQH4"/>
    <dbReference type="OMA" id="SWWFIAN"/>
    <dbReference type="OrthoDB" id="5527234at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052299">
        <property type="entry name" value="CEP76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436:SF2">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_119, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="3">
        <location>
            <begin position="91"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1098"/>
            <end position="1161"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="788"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1023"/>
            <end position="1058"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1100"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1146"/>
            <end position="1155"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51280.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1240" mass="142783" checksum="D3EDB67BE4F92721" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQH5</accession>
    <name>A3FQH5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51281.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388259.1">
        <property type="nucleotide sequence ID" value="XM_001388222.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQH5"/>
    <dbReference type="FunCoup" id="A3FQH5">
        <property type="interactions" value="232"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQH5"/>
    <dbReference type="GeneID" id="3373367"/>
    <dbReference type="KEGG" id="cpv:cgd5_870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_870"/>
    <dbReference type="InParanoid" id="A3FQH5"/>
    <dbReference type="OrthoDB" id="10251371at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010989">
        <property type="entry name" value="SNARE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47661">
        <property type="entry name" value="t-snare proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAZ51281.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="191" mass="22139" checksum="6DF34F9BA7D0E910" modified="2007-04-03" version="1">MKSNTLPPFWVDLHIEAQEELTRAKELISLLQKTQQKRLMCVLKDNTMKLSEIEVDSLTYSICKLFKRIESLAQSISNSPAESKENLPCHKSLINYMILRKNAEISIANELNPLSQQFKFIQKNYMSELQKNYINRLDGVQTNFEDSVIGEQEFNKTSYSCSQTNNQSKEFIFKDANGFNIEVSCEYNNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQK8</accession>
    <name>A3FQK8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Ribonuclease</fullName>
            <ecNumber evidence="10">3.1.26.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd4_2160</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Endonucleolytic cleavage to 5'-phosphomonoester.</text>
            <dbReference type="EC" id="3.1.26.4"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the RNase HII family. Eukaryotic subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.26.4" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51251.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388063.1">
        <property type="nucleotide sequence ID" value="XM_001388026.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQK8"/>
    <dbReference type="STRING" id="353152.A3FQK8"/>
    <dbReference type="GeneID" id="3372827"/>
    <dbReference type="KEGG" id="cpv:cgd4_2160"/>
    <dbReference type="InParanoid" id="A3FQK8"/>
    <dbReference type="OrthoDB" id="7462577at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032299">
        <property type="term" value="C:ribonuclease H2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004523">
        <property type="term" value="F:RNA-DNA hybrid ribonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043137">
        <property type="term" value="P:DNA replication, removal of RNA primer"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.460:FF:000001">
        <property type="entry name" value="Ribonuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.460">
        <property type="entry name" value="Ribonuclease hii. Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001352">
        <property type="entry name" value="RNase_HII/HIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024567">
        <property type="entry name" value="RNase_HII/HIII_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023160">
        <property type="entry name" value="RNase_HII_hlx-loop-hlx_cap_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10954:SF7">
        <property type="entry name" value="RIBONUCLEASE H2 SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01351">
        <property type="entry name" value="RNase_HII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51975">
        <property type="entry name" value="RNASE_H_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 10" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 10" id="KW-0540">Nuclease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNase H type-2" evidence="11">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU003515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51251.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="144" mass="16329" checksum="7DEA5984CF792488" modified="2007-04-03" version="1">MNIFPGINITVKPKADALFPSVSGASILAKVKRDDFLSNWWTQASVESCDFNGNKISNYEQGSGYPGDPKTKDFLRRVFDPVFGFPNIVRFSWSTASEIIEKDGYSVNWGELELNNNQQKINFNRPQQNGKLFSSNFPLNEDMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQN8</accession>
    <name>A3FQN8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit G</fullName>
            <shortName evidence="5">eIF3g</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 RNA-binding subunit</fullName>
            <shortName evidence="5">eIF-3 RNA-binding subunit</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit 4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_1030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAZ51244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388056.1">
        <property type="nucleotide sequence ID" value="XM_001388019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQN8"/>
    <dbReference type="FunCoup" id="A3FQN8">
        <property type="interactions" value="141"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQN8"/>
    <dbReference type="GeneID" id="3372624"/>
    <dbReference type="KEGG" id="cpv:cgd4_1030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1030"/>
    <dbReference type="InParanoid" id="A3FQN8"/>
    <dbReference type="OMA" id="MYSVVHF"/>
    <dbReference type="OrthoDB" id="1749473at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12408">
        <property type="entry name" value="RRM_eIF3G_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03006">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017334">
        <property type="entry name" value="eIF3_g"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024675">
        <property type="entry name" value="eIF3g_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034240">
        <property type="entry name" value="eIF3G_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10352">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12353">
        <property type="entry name" value="eIF3g"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037949">
        <property type="entry name" value="Transl_init_eIF-3_RNA-bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 5 8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="7">
        <location>
            <begin position="270"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="352" mass="39387" checksum="5114E4C1EB0A99B2" modified="2007-04-03" version="1">MSTDFMNVRRSAWADEDIDDFEPSFDEPLKGFESKPDKDGIKHVISYIKDSKGSTIKITKKIKEVRNIIKINKNVVNRRLIMERNLADRFNSDTDVPKLGDEISIDIPKNTDSMNFQDKDNDDDYYFMDLPTSNNNKLSMFKKSGNNYPFILGDEQIEKITYGQQNNSMNDMNSSFTGGFGSNASSSNGLNLGFGTSLTNKGGMSDVKTTVGSGIITSNINSSNNTGINTIGTSIASNNANRYQPPFLRTTSSSAFERGSNLQSSHRDDCTVRVANLSEDATEEDLQELFKTAGRVVKVFLAKNKNNSKNTKGFAFITYSKREEAQNAIRKLNRHGYDNLLLNVEWAKTKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQR4</accession>
    <name>A3FQR4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAZ51206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388295.1">
        <property type="nucleotide sequence ID" value="XM_001388258.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQR4"/>
    <dbReference type="FunCoup" id="A3FQR4">
        <property type="interactions" value="193"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQR4"/>
    <dbReference type="GeneID" id="3375657"/>
    <dbReference type="KEGG" id="cpv:cgd6_250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_250"/>
    <dbReference type="InParanoid" id="A3FQR4"/>
    <dbReference type="OMA" id="CSDIFFE"/>
    <dbReference type="OrthoDB" id="6079689at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008296">
        <property type="term" value="F:3'-5'-DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01310">
        <property type="entry name" value="TatD_DNAse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.140">
        <property type="entry name" value="Metal-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032466">
        <property type="entry name" value="Metal_Hydrolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001130">
        <property type="entry name" value="TatD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050891">
        <property type="entry name" value="TatD-type_Hydrolase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060:SF15">
        <property type="entry name" value="DEOXYRIBONUCLEASE TATDN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10060">
        <property type="entry name" value="TATD FAMILY DEOXYRIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01026">
        <property type="entry name" value="TatD_DNase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005902">
        <property type="entry name" value="DNase_TatD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51556">
        <property type="entry name" value="Metallo-dependent hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0540">Nuclease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="5">
        <location>
            <position position="119"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="156"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="186"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="234"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
            <label>1</label>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009275"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR005902-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="316" mass="36889" checksum="C669491E02AFBBDF" modified="2007-04-03" version="1">MIKSMKELKFIDIGSNLTDLMFQGIYNDKKQHDSDLEIVIKRAIKGGLDKILITAGSYQETVEALKICEELDPKCELLFTTVGVHPTRTKDCKVHSDDYLKRMKDLIRMNSCRIKAIGEFGLDSDRLHFSSMKIQEKYFEKQFELLEEFCLPMFLHIRGDQDCYSKFVRIINEKKSLWIKRGGVAHSFNGNLEQLKMILEMDLEIGVNGCSLKTQDNLNIVENIPLDKLHIETDSPWCDIKPTHSSYHLIETHFPQVNKPSKWEEDKLIKGRNEPIKIIQVAEILFKIYSNNSKFSFNQFIDEIYKNTFKMYFKAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQR6</accession>
    <name>A3FQR6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_280</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAZ51208.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388297.1">
        <property type="nucleotide sequence ID" value="XM_001388260.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQR6"/>
    <dbReference type="GeneID" id="3375658"/>
    <dbReference type="KEGG" id="cpv:cgd6_280"/>
    <dbReference type="InParanoid" id="A3FQR6"/>
    <dbReference type="OMA" id="GNPINEF"/>
    <dbReference type="OrthoDB" id="344372at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="64"/>
            <end position="103"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51208.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="268" mass="31726" checksum="6255E12DBB3442FB" modified="2007-04-03" version="1" fragment="single">IILRNFILELVNDNLFELEINLTGNPINEFFILNKSFPENIHIIFDYSLPLTFSDDLINNLYSSFNGNYDEEGDEEEDEEEEEEEDEEEDEEEENDDKNNHNLIIPVNSYSKEKDESQLVNINSQISNDSFFDKNTSLNTISNPLDDDSLYDSDDDEDYEAEDDEDDDDDDDDDDDDDDDEEEKKEERDDEELEFDSRKDYYNQDIKADEGKKHENGIKNKEQELKIRNQHKKKEKTLIVQEENVIESLISETKSNHLNFKKNQEKWS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPF1</accession>
    <name>Q5CPF1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_5470</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000016">
        <property type="protein sequence ID" value="EAK87304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625311.1">
        <property type="nucleotide sequence ID" value="XM_625311.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPF1"/>
    <dbReference type="STRING" id="353152.Q5CPF1"/>
    <dbReference type="GeneID" id="3375633"/>
    <dbReference type="KEGG" id="cpv:cgd6_5470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5470"/>
    <dbReference type="InParanoid" id="Q5CPF1"/>
    <dbReference type="OrthoDB" id="343904at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254776" evidence="2">
        <location>
            <begin position="22"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="272" mass="31004" checksum="225A0422B43A2D0C" modified="2005-04-12" version="1">MFLHKLIFFLDISLLITDVTSRYSKSKESINQYIFIALKKIQHCIIKSILIIIIMKIFYFICLFISTILQDFYYTIHNNILLIQHIHYYYHEISYIKLSASSQNFRRKKKPKNGVSSSISANGAPLGKCDPFFCHPCDQSGGKGLNCRISKRSGQLVCCYCSNSCTHGPYSPPSNRRNYFKSSCPITCSSPIIIVQNGEEKCSECLNDMFHCGNKPPRPQVTGYYSHPCNSAPHCRLGFFSGPDLKPFCVFCRNQSNHGPYTYESSESDDDN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPF5</accession>
    <name>Q5CPF5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625338.1">
        <property type="nucleotide sequence ID" value="XM_625338.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPF5"/>
    <dbReference type="GeneID" id="3372332"/>
    <dbReference type="KEGG" id="cpv:cgd3_270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_270"/>
    <dbReference type="InParanoid" id="Q5CPF5"/>
    <dbReference type="OMA" id="ICISICN"/>
    <dbReference type="OrthoDB" id="344219at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="976"/>
            <end position="1048"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="978"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="997"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1032"/>
            <end position="1048"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1130" mass="124535" checksum="27CA2CDDFFE25923" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPN7</accession>
    <name>Q5CPN7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625384.1">
        <property type="nucleotide sequence ID" value="XM_625384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPN7"/>
    <dbReference type="GeneID" id="3372369"/>
    <dbReference type="KEGG" id="cpv:cgd2_150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_150"/>
    <dbReference type="InParanoid" id="Q5CPN7"/>
    <dbReference type="OMA" id="KNDCNEY"/>
    <dbReference type="OrthoDB" id="340187at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="324" mass="37548" checksum="E7324B42F7230F84" modified="2005-04-12" version="1">MLGSRKYRRWLNNQLLINKGRAFQIHQYCDNFEFDEIESLIISSSFRDPNYVISPSIWIRLCSDDELHELFLDRKEGNEELGELMITPRESLAIPTRNFLASLKKICSNLDLNENYFLNNENCDENILSENFANINLKHCITGYLSKIFQEVLSLLDRDDLVRFISNIENLIIELIQSNELQKQEKLHENAHKLVIISEKDCKMMKVYNIKDESVDNSFCFLSSEFESHLNSGQSSNSIIIKGCNKLLRKIIHCLCDHYCIISRSISTIGNSNNNNKGNHEKTMILSLPKSSDIITLPKAKITTLLKINQHYSKKQFNSISNLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPP6</accession>
    <name>Q5CPP6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) endonuclease 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd2_40</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <cofactor evidence="11">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
        <text evidence="11">Probably binds two magnesium or manganese ions per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA repair enzymes AP/ExoA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625375.1">
        <property type="nucleotide sequence ID" value="XM_625375.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPP6"/>
    <dbReference type="STRING" id="353152.Q5CPP6"/>
    <dbReference type="GeneID" id="3372342"/>
    <dbReference type="KEGG" id="cpv:cgd2_40"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_40"/>
    <dbReference type="InParanoid" id="Q5CPP6"/>
    <dbReference type="OMA" id="YTVWNTL"/>
    <dbReference type="OrthoDB" id="498125at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003906">
        <property type="term" value="F:DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008311">
        <property type="term" value="F:double-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.10.10">
        <property type="entry name" value="Endonuclease/exonuclease/phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004808">
        <property type="entry name" value="AP_endonuc_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020847">
        <property type="entry name" value="AP_endonuclease_F1_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020848">
        <property type="entry name" value="AP_endonuclease_F1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036691">
        <property type="entry name" value="Endo/exonu/phosph_ase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005135">
        <property type="entry name" value="Endo/exonuclease/phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010666">
        <property type="entry name" value="Znf_GRF"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748">
        <property type="entry name" value="AP ENDONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22748:SF4">
        <property type="entry name" value="DNA-(APURINIC OR APYRIMIDINIC SITE) ENDONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03372">
        <property type="entry name" value="Exo_endo_phos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06839">
        <property type="entry name" value="Zn_ribbon_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56219">
        <property type="entry name" value="DNase I-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00726">
        <property type="entry name" value="AP_NUCLEASE_F1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00728">
        <property type="entry name" value="AP_NUCLEASE_F1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51435">
        <property type="entry name" value="AP_NUCLEASE_F1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51999">
        <property type="entry name" value="ZF_GRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0464">Manganese</keyword>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 13" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="GRF-type" evidence="14">
        <location>
            <begin position="442"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="active site" evidence="10">
        <location>
            <position position="172"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="10">
        <location>
            <position position="245"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="10"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="245"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="363"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="364"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="site" description="Transition state stabilizer" evidence="12">
        <location>
            <position position="247"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity" evidence="12">
        <location>
            <position position="338"/>
        </location>
    </feature>
    <feature type="site" description="Interaction with DNA substrate" evidence="12">
        <location>
            <position position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013541"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR604808-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK87392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="500" mass="57753" checksum="9A108F205587EFC7" modified="2005-04-12" version="1">MRELSIISFNVNGLISFTKRRGYTESNFSKLLDNICVNDEVTSANLNVKSPDIICLQECKMSFGDDLNNSIGCPGNYESYFSLAENNKRYSGVATYCSKKTMVIEAAKGFSWLESNPCQFDINQMIQTEKLQEIESDISKIKDKYGISISEIDGEGRCVITDHKQFVLLNLYVPLLRSKAEEKEEKEKEEVMLKEIQNQNETRIELSETVDPERFKYRLAFQEYLNLLLHVLKNACKRNVILAGDFNIILEKIDCYDDCGILDNCKLAPCMLTSPKEIFETSSFAKAYMHMRRMNIEMIKGYCLVDAYRHYYPRTNNKYTCWSQMNQSRIRNQGTRIDLFLISKGLISESIKCEILDHIYGSDHCPILLILKTGEFESLYNNEKRKPPSICSKYLPQCKQRQSTISQFLTLSKVEVKGQINKTIKSHDFKINNKISLNHPQCKHGIPCVKKKVTKSGVNKGRLYWSCPKSDQQKCNTFSWIEETNSDCKTNHDLKNFVIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPU0</accession>
    <name>Q5CPU0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="21">Lysosomal dipeptide transporter MFSD1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="22">Major facilitator superfamily domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="27" type="ORF">cgd4_4050</name>
    </gene>
    <organism evidence="27 28">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="27 28" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="28">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="23">Lysosomal dipeptide uniporter that selectively exports lysine, arginine or histidine-containing dipeptides with a net positive charge from the lysosome lumen into the cytosol. Could play a role in a specific type of protein O-glycosylation indirectly regulating macrophages migration and tissue invasion. Also essential for liver homeostasis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19">
            <text>L-alanyl-L-lysine(out) = L-alanyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79415"/>
            <dbReference type="ChEBI" id="CHEBI:192470"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>L-alpha-aminoacyl-L-arginine(out) = L-alpha-aminoacyl-L-arginine(in)</text>
            <dbReference type="Rhea" id="RHEA:79367"/>
            <dbReference type="ChEBI" id="CHEBI:229968"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-alpha-aminoacyl-L-histidine(out) = L-alpha-aminoacyl-L-histidine(in)</text>
            <dbReference type="Rhea" id="RHEA:79375"/>
            <dbReference type="ChEBI" id="CHEBI:229967"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-alpha-aminoacyl-L-lysine(out) = L-alpha-aminoacyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79383"/>
            <dbReference type="ChEBI" id="CHEBI:229966"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>L-arginyl-L-alpha-amino acid(out) = L-arginyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79371"/>
            <dbReference type="ChEBI" id="CHEBI:84315"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-arginyl-glycine(out) = L-arginyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79391"/>
            <dbReference type="ChEBI" id="CHEBI:229955"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-aspartyl-L-lysine(out) = L-aspartyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79411"/>
            <dbReference type="ChEBI" id="CHEBI:229953"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>L-histidyl-L-alpha-amino acid(out) = L-histidyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79379"/>
            <dbReference type="ChEBI" id="CHEBI:229964"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-histidyl-glycine(out) = L-histidyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79395"/>
            <dbReference type="ChEBI" id="CHEBI:229957"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-lysyl-L-alanine(out) = L-lysyl-L-alanine(in)</text>
            <dbReference type="Rhea" id="RHEA:79399"/>
            <dbReference type="ChEBI" id="CHEBI:229954"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-lysyl-L-alpha-amino acid(out) = L-lysyl-L-alpha-amino acid(in)</text>
            <dbReference type="Rhea" id="RHEA:79387"/>
            <dbReference type="ChEBI" id="CHEBI:229965"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>L-lysyl-L-lysine(out) = L-lysyl-L-lysine(in)</text>
            <dbReference type="Rhea" id="RHEA:79403"/>
            <dbReference type="ChEBI" id="CHEBI:229956"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="20">
            <text>L-lysyl-glycine(out) = L-lysyl-glycine(in)</text>
            <dbReference type="Rhea" id="RHEA:79407"/>
            <dbReference type="ChEBI" id="CHEBI:191202"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="24">Homodimer. Interacts with lysosomal protein GLMP (via lumenal domain); the interaction starts while both proteins are still in the endoplasmic reticulum and is required for stabilization of MFSD1 in lysosomes but has no direct effect on its targeting to lysosomes or transporter activity.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Lysosome membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="27">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625424.1">
        <property type="nucleotide sequence ID" value="XM_625424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPU0"/>
    <dbReference type="STRING" id="353152.Q5CPU0"/>
    <dbReference type="GeneID" id="3372420"/>
    <dbReference type="KEGG" id="cpv:cgd4_4050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4050"/>
    <dbReference type="InParanoid" id="Q5CPU0"/>
    <dbReference type="OMA" id="CVLYYSA"/>
    <dbReference type="OrthoDB" id="424834at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005765">
        <property type="term" value="C:lysosomal membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052187">
        <property type="entry name" value="MFSD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23512:SF3">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0458">Lysosome</keyword>
    <keyword evidence="6 25" id="KW-0472">Membrane</keyword>
    <keyword evidence="28" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 25 27" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 25" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="15"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="90"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="120"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="151"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="182"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="267"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="309"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="339"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="392"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="25">
        <location>
            <begin position="424"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="26">
        <location>
            <begin position="21"/>
            <end position="449"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008335"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00044876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044881"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00044884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00044891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00044893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00044899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00044900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044903"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00044912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00044919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00044924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00044985"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00045018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00045709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00046376"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="27">
        <source>
            <dbReference type="EMBL" id="EAK87435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="28">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="601" mass="66669" checksum="8BD00AFDE33FDD6F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPZ9</accession>
    <name>Q5CPZ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Ubiquitin activating enzyme E1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625480.1">
        <property type="nucleotide sequence ID" value="XM_625480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPZ9"/>
    <dbReference type="STRING" id="353152.Q5CPZ9"/>
    <dbReference type="GeneID" id="3372498"/>
    <dbReference type="KEGG" id="cpv:cgd8_160"/>
    <dbReference type="InParanoid" id="Q5CPZ9"/>
    <dbReference type="OMA" id="AFINEYC"/>
    <dbReference type="OrthoDB" id="1708823at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="509" mass="58666" checksum="8A9B8BA9FBEF6E5F" modified="2005-04-12" version="1">MDQFRSRERLIWGVVGEEALKNSKILILGSSSILTSELAISLASSGIGEIVLVDCQIATEEDYGVCLSLDGEKTNIVNQPKIYLLKDFLLSLQVNIRIKCVLESPEKYLETLMNEPLNSHPLEYSVVVCCNLPGNIVENVYNLAKNGQGISSCFIISLKSRGELGQYQVFSTNQMYVTFDLSAESKNLAKLHGLQLFKPIESLINLASEIDFKELEDSSSGLNDFLSKIPFPILLVYIGLNAGLFRGSEFGMDRENLKKRFKDSLEQILKDYDFPNYIEAKRYQYLVFSDPEDLLGDQIFQLLESQKLYSNFNGQFSLNKRSFSTINVKYQIVLSWIYKFLNDFGRLPVNKELPEMHCETVSYLQLQKIFHEQYTLDVSRISNSNTGKMNISNSDFDLNISDELVQFVCRHLYCLRFIEFKNTSFRWGEIHNKISNVDPALTERLVEVFLEDISQESQLIEFLFLDFLDYIHIDKGLIKDSEEIKTNFQNYLKSLRLEYIQIPPDFIQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ32</accession>
    <name>Q5CQ32_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Frataxin like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_4320</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the frataxin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625594.1">
        <property type="nucleotide sequence ID" value="XM_625594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ32"/>
    <dbReference type="STRING" id="353152.Q5CQ32"/>
    <dbReference type="GeneID" id="3372578"/>
    <dbReference type="KEGG" id="cpv:cgd5_4320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4320"/>
    <dbReference type="InParanoid" id="Q5CQ32"/>
    <dbReference type="OMA" id="DIDCHNE"/>
    <dbReference type="OrthoDB" id="1897642at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008199">
        <property type="term" value="F:ferric iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004322">
        <property type="term" value="F:ferroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034986">
        <property type="term" value="F:iron chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006826">
        <property type="term" value="P:iron ion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.920.10">
        <property type="entry name" value="Frataxin/CyaY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002908">
        <property type="entry name" value="Frataxin/CyaY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036524">
        <property type="entry name" value="Frataxin/CyaY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020895">
        <property type="entry name" value="Frataxin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821">
        <property type="entry name" value="FRATAXIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16821:SF2">
        <property type="entry name" value="FRATAXIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01491">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01219">
        <property type="entry name" value="Frataxin_Cyay"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55387">
        <property type="entry name" value="Frataxin/Nqo15-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01344">
        <property type="entry name" value="FRATAXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50810">
        <property type="entry name" value="FRATAXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0406">Ion transport</keyword>
    <keyword evidence="3" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0410">Iron transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008183"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="173" mass="20179" checksum="267B3B5E94933CD0" modified="2005-04-12" version="1">MNSIKLLNLKVVQNLSKFNTQYKVFNFRKSISTLKFLCDRNSKFVPPLAHNLLKLKKNRIYTNSSDISQFSSKTEGLFFEIEKKLSDLLDNGLLSDIDLHDEFMNISFNLNGEKNTIVISKQPATNQIWYSSPLRKPDYFEFNSDWRSNRTNKTLFEVLNDDLYKATGIHVNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ77</accession>
    <name>Q5CQ77_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Adapter-protein complex 1 gamma subunit (Gamma adaptin)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd5_3850</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasmic vesicle membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87598.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625549.1">
        <property type="nucleotide sequence ID" value="XM_625549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ77"/>
    <dbReference type="FunCoup" id="Q5CQ77">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ77"/>
    <dbReference type="GeneID" id="3372558"/>
    <dbReference type="KEGG" id="cpv:cgd5_3850"/>
    <dbReference type="InParanoid" id="Q5CQ77"/>
    <dbReference type="OMA" id="AICAMRI"/>
    <dbReference type="OrthoDB" id="28053at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030121">
        <property type="term" value="C:AP-1 adaptor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017107">
        <property type="entry name" value="AP1_complex_gsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008153">
        <property type="entry name" value="GAE_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037094">
        <property type="entry name" value="AP1_complex_gamma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00809">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50180">
        <property type="entry name" value="GAE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GAE" evidence="9">
        <location>
            <begin position="845"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87598.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="966" mass="108686" checksum="EC39A69A6A6B290C" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQC9</accession>
    <name>Q5CQC9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Ribosome biogenesis regulatory protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_1220</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Involved in ribosomal large subunit assembly.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 5">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the RRS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625719.1">
        <property type="nucleotide sequence ID" value="XM_625719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQC9"/>
    <dbReference type="FunCoup" id="Q5CQC9">
        <property type="interactions" value="279"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQC9"/>
    <dbReference type="GeneID" id="3372650"/>
    <dbReference type="KEGG" id="cpv:cgd4_1220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1220"/>
    <dbReference type="InParanoid" id="Q5CQC9"/>
    <dbReference type="OMA" id="FVHEYKP"/>
    <dbReference type="OrthoDB" id="28455at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007023">
        <property type="entry name" value="Ribosom_reg"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04939">
        <property type="entry name" value="RRS1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="148"/>
            <end position="182"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU364132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="263" mass="30323" checksum="BC3EA23F58CA2795" modified="2005-04-12" version="1">MEGAQLETSPLEVCLSNLIGIDISSINETEINKSGANNLQLMLNSIWSDLSKENTKDGTVVSLPSNQEILLPRAYPLPTKKEKTRWEKFAELKGIKKRKRSRMVYDPITDDFVPRWGRNSIKKIQKKHNEAIIEIKGNMDENKDPREAINLKRDMMINKQRLRELKNKMNSSKNINNQKSDEFALGIGNLKDTNVKRSKTQVKELFDRVSLSTASYGRRDKALPDEDRTTNKVKKVKKILDTKNENEKYKSIYSKILKQNSNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQD0</accession>
    <name>Q5CQD0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Branchpoint-bridging protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd4_1210</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 11">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the BBP/SF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87624.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625718.1">
        <property type="nucleotide sequence ID" value="XM_625718.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQD0"/>
    <dbReference type="STRING" id="353152.Q5CQD0"/>
    <dbReference type="GeneID" id="3372651"/>
    <dbReference type="KEGG" id="cpv:cgd4_1210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1210"/>
    <dbReference type="InParanoid" id="Q5CQD0"/>
    <dbReference type="OMA" id="TSDCKLA"/>
    <dbReference type="OrthoDB" id="6777263at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045131">
        <property type="term" value="F:pre-mRNA branch point binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048024">
        <property type="term" value="P:regulation of mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02395">
        <property type="entry name" value="KH-I_BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045071">
        <property type="entry name" value="BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055256">
        <property type="entry name" value="KH_1_KHDC4/BBP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032570">
        <property type="entry name" value="SF1-HH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047086">
        <property type="entry name" value="SF1-HH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208">
        <property type="entry name" value="RNA-BINDING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11208:SF45">
        <property type="entry name" value="SPLICING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22675">
        <property type="entry name" value="KH-I_KHDC4-BBP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16275">
        <property type="entry name" value="SF1-HH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00343">
        <property type="entry name" value="ZnF_C2HC"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3 11" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8 11" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="11" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="6 11" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 10 11" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="13">
        <location>
            <begin position="332"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="451"/>
            <end position="471"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="460"/>
            <end position="471"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU367126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK87624.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="471" mass="53771" checksum="ACAEE598ADA0B73D" modified="2005-04-12" version="1">MEADITPIGNSTGGNNIYFKGNNPGQISIAEISNDNISKRESRWSKVSDGSTSRWKSVYEKEYIPPAYSDFPPGMSNYEIDQFLREQRLDELIYKLQMGEIEYGSPDIREPSPPPIYDKNGSRINTREVRVRKNMEEELSNLIEYMSKNVEGYVVPKDYKPLKKTKKLIIPLDKYPDYNFMGLIIGPRGYNHRRLEAESGTQISIRGKGTTKEGKKCDHQTEEELAMPMHIHITAESQYKLDKAVSMIQPLLDPFHPLHEEYKRDGLQQLAIINGTLNTNLNNSSSLINTFSSGNTAITLTKGCLHCGSTQHPTYACPDVNSLNSFKRPDIKCSICGDKGHITKDCKQYVPNNNVEEEFKKMMIELGHEVNYNTEATNNVIEHSSSEYNPNGDYYESLYSNNDGQSYYQNGYDQQNYEYQTEMNNDSTNFAYQTYQSSIYNNIMLNNGSIHNQLNSSNNNDDDDDNMDESD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQG3</accession>
    <name>Q5CQG3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_830</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87653.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625685.1">
        <property type="nucleotide sequence ID" value="XM_625685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQG3"/>
    <dbReference type="GeneID" id="3372698"/>
    <dbReference type="KEGG" id="cpv:cgd4_830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_830"/>
    <dbReference type="InParanoid" id="Q5CQG3"/>
    <dbReference type="OMA" id="IPMNERI"/>
    <dbReference type="OrthoDB" id="337932at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87653.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="325" mass="38844" checksum="46EA49C14786490A" modified="2005-04-12" version="1">MSKDEELALRKSIRKYNTNERALQKIQGDVLERLRRATELENPYQIKTNRKKQLDQTKYENNLSQIICQDYYPDLDYMNKNKDDHESIKSIINNPPGTLNMNDFPHIEDYESNKDLLVCKKLPNITQFQSKYTHKGHLDLLALTNQDLIQRREKESWIEHQSFNHNLKREMNIIQMNQKNSNQINDFDEKSLIFNKSQSRSNFMFPNHNHHNQLKKEVNTPQDREKLINPSNTRYNYMDDFEKDERMLLLKEIQTKRKQIHLDKAQNLNPIFLDNKKTSKNLLMKSPLVKNALRRLNKSDILFDNQLRDSYSYKGNSKQSLSRIT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQN4</accession>
    <name>Q5CQN4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">APG7-like ubiquitin activating enzyme E1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_40</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87707.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625614.1">
        <property type="nucleotide sequence ID" value="XM_625614.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQN4"/>
    <dbReference type="STRING" id="353152.Q5CQN4"/>
    <dbReference type="GeneID" id="3372607"/>
    <dbReference type="KEGG" id="cpv:cgd4_40"/>
    <dbReference type="InParanoid" id="Q5CQN4"/>
    <dbReference type="OMA" id="VICFREY"/>
    <dbReference type="OrthoDB" id="338614at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000407">
        <property type="term" value="C:phagophore assembly site"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019778">
        <property type="term" value="F:Atg12 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019779">
        <property type="term" value="F:Atg8 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000045">
        <property type="term" value="P:autophagosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000422">
        <property type="term" value="P:autophagy of mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006995">
        <property type="term" value="P:cellular response to nitrogen starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034727">
        <property type="term" value="P:piecemeal microautophagy of the nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032446">
        <property type="term" value="P:protein modification by small protein conjugation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01486">
        <property type="entry name" value="Apg7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF3">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME ATG7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="1">
        <location>
            <begin position="235"/>
            <end position="479"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87707.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="569" mass="64970" checksum="B32F1AAB52BE1387" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQN8</accession>
    <name>Q5CQN8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_3890</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625964.1">
        <property type="nucleotide sequence ID" value="XM_625964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQN8"/>
    <dbReference type="GeneID" id="3372914"/>
    <dbReference type="KEGG" id="cpv:cgd4_3890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3890"/>
    <dbReference type="InParanoid" id="Q5CQN8"/>
    <dbReference type="OrthoDB" id="430637at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12352">
        <property type="entry name" value="V-SNARE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="236" mass="28059" checksum="0F75D8441359A74A" modified="2005-04-12" version="1">MSSFIPGIRKEHLEESLEDSVENSIEDDLLSEYFQELSSLIEELKQGKEIFQQNKAKYTEQEKAKYQALILSSQKLLEIIYFEIHFSESNTRNYQDFQNYIKYKENLSKLYQDFSKFVVFVESDNKNEEILISNSSSKEDTNFDSSLNNNDLLLEKNKEYIFEENIKEKTSKDYYLLQSKRLLEETNQYSQQILLNLNTQKEQLISTDNKMGNISKSLQDSSLLIDKMTRWWHQLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQW3</accession>
    <name>Q5CQW3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_3050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87809.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625889.1">
        <property type="nucleotide sequence ID" value="XM_625889.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQW3"/>
    <dbReference type="GeneID" id="3372987"/>
    <dbReference type="KEGG" id="cpv:cgd4_3050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3050"/>
    <dbReference type="InParanoid" id="Q5CQW3"/>
    <dbReference type="OMA" id="CNINPEG"/>
    <dbReference type="OrthoDB" id="337834at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="158"/>
            <end position="269"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="321"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="326"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87809.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="365" mass="41285" checksum="C771D2839EA2849E" modified="2005-04-12" version="1">MKIFILNPFGIKILKIVFLILINYNIFPGVNGKSAYTDIIPDDYTYLVRSKIKTVDKPIDMLLHLSRSEAPKYTVVLFNVYTIIKAVKKLSTSMYVHLVRHLDHYDREFSDNVQFIIPNFYPNVRSIISSMGHKVHASLISGTIPEEKYIEAVVASVSFINNAIRRGVIPSHQTTAFYGNCVGGLIASATSVALRESLAAVVLNGSALFMPDVVRRRLARKSALKSVKYLLIHSYEDQVIPYIHAENTNNSLVSWGADSTIYNVEKISHFDTMVKHKYTGLRFISSVILKRPEIYRPLDTEDQELIKSTKKRMKAEDIEPIVPPRNSTIGTDDSSSSNTTISRQSRPNLVIREERNMVYIIDQSG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR00</accession>
    <name>Q5CR00_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Similarity at COOH terminus with programmed cell death protein 2</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625852.1">
        <property type="nucleotide sequence ID" value="XM_625852.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR00"/>
    <dbReference type="STRING" id="353152.Q5CR00"/>
    <dbReference type="GeneID" id="3372844"/>
    <dbReference type="KEGG" id="cpv:cgd4_2660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2660"/>
    <dbReference type="InParanoid" id="Q5CR00"/>
    <dbReference type="OMA" id="TINCSEC"/>
    <dbReference type="OrthoDB" id="366284at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052815">
        <property type="entry name" value="PDCD2-like_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007320">
        <property type="entry name" value="PDCD2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46421">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46421:SF1">
        <property type="entry name" value="PROGRAMMED CELL DEATH PROTEIN 2-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04194">
        <property type="entry name" value="PDCD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Programmed cell death protein 2 C-terminal" evidence="1">
        <location>
            <begin position="171"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="276" mass="32099" checksum="B56D5B58CE91EBA9" modified="2005-04-12" version="1">METILNLFFRNTPYSIVKRRVIYLFYCENNYCSMNWTTFRSSVESNLHNATESFPNKESSILTDDWLQSAGIDINTSVTNQNIQNDSKIIENLFSRKLDQKSYLIKYISESDVDNGDIKIKFLLDSYISNADNDPIEIEKCSDSDVSSDKSDNEYLDPSNAEESCYIFDKDRYLHNFSSEISKFPRQIIRYCFGGTPLYSESPKKINIPTCKECGSNKVFEFQIISSIIYEWENLFGEKDIFCKCSSEWSTIIIYTCSKDCNTEFSEETAIIQYFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR36</accession>
    <name>Q5CR36_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S acidic ribosomal protein P0</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_2260</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Ribosomal protein P0 is the functional equivalent of E.coli protein L10.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the universal ribosomal protein uL10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87938.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625816.1">
        <property type="nucleotide sequence ID" value="XM_625816.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR36"/>
    <dbReference type="FunCoup" id="Q5CR36">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR36"/>
    <dbReference type="GeneID" id="3372982"/>
    <dbReference type="KEGG" id="cpv:cgd4_2260"/>
    <dbReference type="InParanoid" id="Q5CR36"/>
    <dbReference type="OMA" id="DMNPFKL"/>
    <dbReference type="OrthoDB" id="10259902at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070180">
        <property type="term" value="F:large ribosomal subunit rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05795">
        <property type="entry name" value="Ribosomal_P0_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.105.20:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1730">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.105.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050323">
        <property type="entry name" value="Ribosomal_protein_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001790">
        <property type="entry name" value="Ribosomal_uL10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040637">
        <property type="entry name" value="Ribosomal_uL10-like_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043164">
        <property type="entry name" value="Ribosomal_uL10-like_insert_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043141">
        <property type="entry name" value="Ribosomal_uL10-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030670">
        <property type="entry name" value="uL10_eukaryotes"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P0"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45699:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00466">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17777">
        <property type="entry name" value="RL10P_insert"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039087">
        <property type="entry name" value="L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF160369">
        <property type="entry name" value="Ribosomal protein L10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL10-like insertion" evidence="6">
        <location>
            <begin position="119"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="294"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="302"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008889"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR039087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF17777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87938.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="318" mass="34310" checksum="8D85BBDE835F6C28" modified="2005-04-12" version="1" fragment="single">LLNCKALTMPSPEKAAKKKQYFERLSEYATSYPRILVANADHVGSKQMADIRLALRGKAAVLMGKNTMIRTALKQMLGSHPELEKLIELVRLNVGLIFCIDEPSEVRKIIEEYRVPAPARQGVIAPCNVVVPAGATGLDPSQTSFFQALGIATKIVKGQVEIQSDVNLIDEGKKVTASQAVLLQKLNIKPFSYGLKVNNIYDHGSVYSSSVLDITSEDLISRVAEATKYVAAFSKETAIPTLPSARDGIISSFRNCVALGLDVDFDFPEMQAIKNALANPSSFVAASTAADNTTAVGASAPVEEEEEEEGDLGFSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR98</accession>
    <name>Q5CR98_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Putative rRNA methyltransferase</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">2'-O-ribose RNA methyltransferase SPB1 homolog</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd4_1580</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>a ribonucleotide in rRNA + S-adenosyl-L-methionine = a 2'-O-methylribonucleotide in rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:48628"/>
            <dbReference type="Rhea" id="RHEA-COMP:12164"/>
            <dbReference type="Rhea" id="RHEA-COMP:12165"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:90675"/>
            <dbReference type="ChEBI" id="CHEBI:90676"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87915.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625754.1">
        <property type="nucleotide sequence ID" value="XM_625754.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR98"/>
    <dbReference type="FunCoup" id="Q5CR98">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR98"/>
    <dbReference type="GeneID" id="3372931"/>
    <dbReference type="KEGG" id="cpv:cgd4_1580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1580"/>
    <dbReference type="InParanoid" id="Q5CR98"/>
    <dbReference type="OMA" id="MAGGDSH"/>
    <dbReference type="OrthoDB" id="1287559at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016435">
        <property type="term" value="F:rRNA (guanine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008650">
        <property type="term" value="F:rRNA (uridine-2'-O-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000004">
        <property type="entry name" value="AdoMet-dependent rRNA methyltransferase SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01547">
        <property type="entry name" value="RNA_methyltr_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03163">
        <property type="entry name" value="RNA_methyltr_E_SPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050082">
        <property type="entry name" value="RNA_methyltr_RlmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002877">
        <property type="entry name" value="RNA_MeTrfase_FtsJ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015507">
        <property type="entry name" value="rRNA-MeTfrase_E"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012920">
        <property type="entry name" value="rRNA_MeTfrase_SPB1-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024576">
        <property type="entry name" value="rRNA_MeTfrase_Spb1_DUF3381"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028589">
        <property type="entry name" value="SPB1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920:SF13">
        <property type="entry name" value="PRE-RRNA 2'-O-RIBOSE RNA METHYLTRANSFERASE FTSJ3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10920">
        <property type="entry name" value="RIBOSOMAL RNA METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11861">
        <property type="entry name" value="DUF3381"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01728">
        <property type="entry name" value="FtsJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07780">
        <property type="entry name" value="Spb1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 13" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA methyltransferase FtsJ" evidence="10">
        <location>
            <begin position="24"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="DUF3381" evidence="12">
        <location>
            <begin position="276"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="domain" description="Ribosomal RNA methyltransferase SPB1-like C-terminal" evidence="11">
        <location>
            <begin position="773"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="226"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="386"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="570"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="624"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="692"/>
            <end position="803"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="986"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="236"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="394"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="576"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="631"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="641"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="731"/>
            <end position="746"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="761"/>
            <end position="771"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="788"/>
            <end position="798"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="987"/>
            <end position="1011"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="8">
        <location>
            <position position="157"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="58"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="92"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF07780"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF11861"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK87915.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1011" mass="117199" checksum="67143FD1D19F4E72" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRA3</accession>
    <name>Q5CRA3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_3600</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88049.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626283.1">
        <property type="nucleotide sequence ID" value="XM_626283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRA3"/>
    <dbReference type="STRING" id="353152.Q5CRA3"/>
    <dbReference type="GeneID" id="3373107"/>
    <dbReference type="KEGG" id="cpv:cgd5_3600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3600"/>
    <dbReference type="InParanoid" id="Q5CRA3"/>
    <dbReference type="OrthoDB" id="341222at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88049.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="457" mass="53705" checksum="5947C43863F28573" modified="2005-04-12" version="1">MKISIKICLTLISCFTILILFLQFNTVYSESAKSIDEELDTRKSPNLGIESSEIENKLLVTTRRSSFDSMVAKSFRERRESSKSSETSLSSKEEEITKIEKEIETNLFREVISVVIMEFETFVFKSGYLFLTNFWLDMRSNFDNIDIVKGLVDYWGGEESEDLYPSLVSFFYKENMKRLKMYLYPSFDKKLKPKKKLLKDFLYNAYRLSCQDSKKSLAILILMFQREVNLIYTSYLLFLISCSHKDFYQMEFVEIFQLILHNTDFAEDKIVSIADKNVETFIKFFKKKLKIEHSNLPSNNKIKTLNPLNMHKIDFEIFGLNFCESLLEISILKNVIFLYNYLIFLFGSRFSKPEEVLIATDMFKFVSSSATTTTEIIAMLLFNESTFTSLKSKMFLLHGVDISALKNRFKECIQKIDSYRELNGIRFLTDFQEKSTRRNDPNELIKNRLRSKFAFLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRA8</accession>
    <name>Q5CRA8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible glycolipid transfer protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_3550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88045.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626278.1">
        <property type="nucleotide sequence ID" value="XM_626278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRA8"/>
    <dbReference type="FunCoup" id="Q5CRA8">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRA8"/>
    <dbReference type="GeneID" id="3373103"/>
    <dbReference type="KEGG" id="cpv:cgd5_3550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3550"/>
    <dbReference type="InParanoid" id="Q5CRA8"/>
    <dbReference type="OMA" id="WMKRTIE"/>
    <dbReference type="OrthoDB" id="205255at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902387">
        <property type="term" value="F:ceramide 1-phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902388">
        <property type="term" value="F:ceramide 1-phosphate transfer activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3520.10">
        <property type="entry name" value="Glycolipid transfer protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036497">
        <property type="entry name" value="GLTP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014830">
        <property type="entry name" value="Glycolipid_transfer_prot_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219">
        <property type="entry name" value="GLYCOLIPID TRANSFER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10219:SF25">
        <property type="entry name" value="PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08718">
        <property type="entry name" value="GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110004">
        <property type="entry name" value="Glycolipid transfer protein, GLTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Glycolipid transfer protein" evidence="2">
        <location>
            <begin position="59"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF08718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88045.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="245" mass="27855" checksum="53E698AB9D0B09D5" modified="2005-04-12" version="1">MNGLKVCNSQRELVQNSKRIFHSKDSHLRSYPNLECITTAFRNSVIYPETVNNPPVPLFEQFCKAAVLYSDFYQFALGENFVCNLLRNDIKNNSSQAMEAWKRESSDAKTVEEFLKSQIRIHTLDKIRSNPSSAIIKFLWTVRATNFIQRFIENLISTTGEDLHCSARDAYNKSLRPYHGYVKVGIAIMAFKLVPSKTNLILSLGYPDIESGITALRKLSSASKPCIDQINGLIEKYGCNFQNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRC2</accession>
    <name>Q5CRC2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_3390</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626264.1">
        <property type="nucleotide sequence ID" value="XM_626264.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373053"/>
    <dbReference type="KEGG" id="cpv:cgd5_3390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3390"/>
    <dbReference type="InParanoid" id="Q5CRC2"/>
    <dbReference type="OMA" id="ASINDYC"/>
    <dbReference type="OrthoDB" id="340097at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="3709" mass="435278" checksum="A834866395B0CB36" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRD1</accession>
    <name>Q5CRD1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Transcription elongation factor TFIIS</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88027.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626255.1">
        <property type="nucleotide sequence ID" value="XM_626255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRD1"/>
    <dbReference type="STRING" id="353152.Q5CRD1"/>
    <dbReference type="GeneID" id="3373047"/>
    <dbReference type="KEGG" id="cpv:cgd5_3290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3290"/>
    <dbReference type="InParanoid" id="Q5CRD1"/>
    <dbReference type="OMA" id="PNCFDIT"/>
    <dbReference type="OrthoDB" id="1742074at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.30">
        <property type="entry name" value="Transcription elongation factor S-II, central domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003618">
        <property type="entry name" value="TFIIS_cen_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036575">
        <property type="entry name" value="TFIIS_cen_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07500">
        <property type="entry name" value="TFIIS_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46942">
        <property type="entry name" value="Elongation factor TFIIS domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51321">
        <property type="entry name" value="TFIIS_CENTRAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TFIIS central" evidence="1">
        <location>
            <begin position="5"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88027.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="233" mass="27349" checksum="0ACCD219B93C5FEC" modified="2005-04-12" version="1">MEGSMQTELRNALEQGLVENKTFKNVDIYSLSKSIEEDFLKVMAGKDSRIIRQRRFELMSNLKRPNNLDLRRRILAGEMSVREFVTCPVSELAPDSVKQQRLEEQKRYFKEECILMMNDRDSSEINEKKRNNSFDGINDEMTEYNIETAKDLTEESENDTLMAKKSKRFKNDKNILEIFPDLPISLAVPPDLSHITPRYNLNKYIDKYKEMIKDVNIQNELIKQAKLRIVTTT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRP3</accession>
    <name>Q5CRP3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Extracellular protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88066.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626143.1">
        <property type="nucleotide sequence ID" value="XM_626143.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRP3"/>
    <dbReference type="SMR" id="Q5CRP3"/>
    <dbReference type="STRING" id="353152.Q5CRP3"/>
    <dbReference type="GeneID" id="3373265"/>
    <dbReference type="KEGG" id="cpv:cgd5_2020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2020"/>
    <dbReference type="InParanoid" id="Q5CRP3"/>
    <dbReference type="OMA" id="NSYCENK"/>
    <dbReference type="OrthoDB" id="335796at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd05380">
        <property type="entry name" value="CAP_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.33.10">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014044">
        <property type="entry name" value="CAP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035940">
        <property type="entry name" value="CAP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001283">
        <property type="entry name" value="CRISP-related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002413">
        <property type="entry name" value="V5_allergen-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10334">
        <property type="entry name" value="CYSTEINE-RICH SECRETORY PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00188">
        <property type="entry name" value="CAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00838">
        <property type="entry name" value="V5ALLERGEN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00198">
        <property type="entry name" value="SCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55797">
        <property type="entry name" value="PR-1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254301" evidence="1">
        <location>
            <begin position="21"/>
            <end position="413"/>
        </location>
    </feature>
    <feature type="domain" description="SCP" evidence="2">
        <location>
            <begin position="28"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88066.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="413" mass="46278" checksum="05A2E88E60F4D965" modified="2005-04-12" version="1">MRNFVILKIILFSFLDLIYSQVNIMTDEYRIKILNMHNELRAKEASSATYMIKLAYDYSLEGYAANWGMKCMNGQFQHSPQTWPNRASPGENLYASSIDVSKLSSWDPSNVVKSWWDEREHFNWKMGVPEGGYPVGHWTQVVRAAASTVGCAVIVRCPGSWKTYVICHYDFGNLGYIPYPNFKVDKSLPQKPCSQCPSGYNCCENNLCVGIINPKIPPPGELPIKSGNGACDDYMKRLCSIRNGACPQSCLDLEYPTIKKGLIVQQCTCIEGESVSPTMAWQFKLWYNRGNCSRVKGNDGSSYSMKGLVDSGVAKIGTHDLDIDVSLKNRNELKKIGTNRFARDLSFMDEAHVDIKHGPGLIADISTEQDNRENNIPTKGDINSTSNLEHFPSYSNSLAKIRNLSNGEREAIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRP9</accession>
    <name>Q5CRP9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CAAX prenyl protease 2/Lysostaphin resistance protein A-like domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_1950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626137.1">
        <property type="nucleotide sequence ID" value="XM_626137.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRP9"/>
    <dbReference type="GeneID" id="3373270"/>
    <dbReference type="KEGG" id="cpv:cgd5_1950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1950"/>
    <dbReference type="InParanoid" id="Q5CRP9"/>
    <dbReference type="OMA" id="ICIHIGI"/>
    <dbReference type="OrthoDB" id="337361at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004175">
        <property type="term" value="F:endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080120">
        <property type="term" value="P:CAAX-box protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003675">
        <property type="entry name" value="Rce1/LyrA-like_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02517">
        <property type="entry name" value="Rce1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="269"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="domain" description="CAAX prenyl protease 2/Lysostaphin resistance protein A-like" evidence="2">
        <location>
            <begin position="135"/>
            <end position="281"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="292" mass="33750" checksum="26095C3CFEB34CEC" modified="2005-04-12" version="1">MISFIFKNKQFVKIVIIALLPCLNALFWLFFISNGWLAMYSMHFICMFFIPTFFYGLQYLTSNLSDAREYGKNFDILKCICVCIFTSFFGTTCLFLVSELSKIIPTFDLLNIEEIKNGLLKEGIIKDPTNKIGFSTWFSSIYFSIVNPIIEELFWRSFVYKELIISLGVRNETNPQSRFNINEIGAHYSDFLIARDHSSNLFESYDVESGQIGYKVNTELASIICSVLYSLYHFFVLIRFSSIHCSILSTISLAIIGRALLYVNRKFHTIYSVYIHIGMDISIVIFLLLSLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRT5</accession>
    <name>Q5CRT5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_1540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626101.1">
        <property type="nucleotide sequence ID" value="XM_626101.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRT5"/>
    <dbReference type="GeneID" id="3373021"/>
    <dbReference type="KEGG" id="cpv:cgd5_1540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1540"/>
    <dbReference type="InParanoid" id="Q5CRT5"/>
    <dbReference type="OMA" id="DYIICAC"/>
    <dbReference type="OrthoDB" id="337053at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254172" evidence="2">
        <location>
            <begin position="20"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="216"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="460" mass="54642" checksum="940A89A0E3A621CC" modified="2005-04-12" version="1">MKFMLYALVIFLSYGSIHSANNQTEQSIFNEPCEYTTSKEVKSMFNVFAFNQKRFGKKKGKVEQIVAKFVCKKKPLIIANDWSQEDYMVISFIIFLSKRLDLATKTFEIKKYNNWIFGNVPPLEELSRGITHFNPLPEWRSWWEKEGDSKKILKQINEIYLSITNTPDTFRFSDKSASNKITKPFLSLAYIFSREMIKDKALIKNISRNSYREEVIKNLETKTNQFNSELNLENSNINEQSLKLEKDLYKSDHISLFKKAYNHVLFVKKKRNFNSENGDNNIELLPNWWEKELDIVTAIILTIFKYQYRHRMQIIEAENKIKNDNLNWKKIHNCIKQAIFCTSNGSSNNSLEHIPIWHRFGEKWQSFPQGAMIRILDNVSKLSLTTSGWDVYDYVICLCFYYLIKRERIRIDWFTLGPLSGSPRTRFWRRFKRYVINMFSSNKGMFDMNNKWHSSPVELE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRV3</accession>
    <name>Q5CRV3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Superfamily I helicase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_1360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626083.1">
        <property type="nucleotide sequence ID" value="XM_626083.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRV3"/>
    <dbReference type="GeneID" id="3373291"/>
    <dbReference type="KEGG" id="cpv:cgd5_1360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1360"/>
    <dbReference type="InParanoid" id="Q5CRV3"/>
    <dbReference type="OMA" id="ITWENEY"/>
    <dbReference type="OrthoDB" id="426371at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052957">
        <property type="entry name" value="Auxin_embryo_med"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058210">
        <property type="entry name" value="SACS/Nov_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007527">
        <property type="entry name" value="Znf_SWIM"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF047352">
        <property type="entry name" value="P_loop_sacsin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387:SF0">
        <property type="entry name" value="PROTEIN NO VEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32387">
        <property type="entry name" value="WU:FJ29H11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25794">
        <property type="entry name" value="SACS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50966">
        <property type="entry name" value="ZF_SWIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SWIM-type" evidence="2">
        <location>
            <begin position="34"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00325"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2023" mass="237074" checksum="8C04F60F69037F19" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS12</accession>
    <name>Q5CS12_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Extracellular protein with a ricin domain and a family 2 glycosyltransferase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_690</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88160.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626024.1">
        <property type="nucleotide sequence ID" value="XM_626024.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS12"/>
    <dbReference type="STRING" id="353152.Q5CS12"/>
    <dbReference type="GeneID" id="3373167"/>
    <dbReference type="KEGG" id="cpv:cgd5_690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_690"/>
    <dbReference type="InParanoid" id="Q5CS12"/>
    <dbReference type="OMA" id="IPYPCHL"/>
    <dbReference type="OrthoDB" id="9982049at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030246">
        <property type="term" value="F:carbohydrate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.80.10.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000772">
        <property type="entry name" value="Ricin_B_lectin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF126">
        <property type="entry name" value="RICIN B LECTIN DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00652">
        <property type="entry name" value="Ricin_B_lectin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00458">
        <property type="entry name" value="RICIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="2" id="KW-0430">Lectin</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="28"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="domain" description="Ricin B lectin" evidence="6">
        <location>
            <begin position="592"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004323"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022734"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88160.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="732" mass="83344" checksum="456F718D753DF536" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="87" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS18</accession>
    <name>Q5CS18_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Alanine racemase N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_620</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626018.1">
        <property type="nucleotide sequence ID" value="XM_626018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS18"/>
    <dbReference type="FunCoup" id="Q5CS18">
        <property type="interactions" value="134"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS18"/>
    <dbReference type="GeneID" id="3373309"/>
    <dbReference type="KEGG" id="cpv:cgd5_620"/>
    <dbReference type="InParanoid" id="Q5CS18"/>
    <dbReference type="OMA" id="PLEWHMI"/>
    <dbReference type="OrthoDB" id="10264196at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030170">
        <property type="term" value="F:pyridoxal phosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06822">
        <property type="entry name" value="PLPDE_III_YBL036c_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.10:FF:000018">
        <property type="entry name" value="Pyridoxal phosphate homeostasis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.10">
        <property type="entry name" value="Alanine racemase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02087">
        <property type="entry name" value="PLP_homeostasis"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001608">
        <property type="entry name" value="Ala_racemase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029066">
        <property type="entry name" value="PLP-binding_barrel"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011078">
        <property type="entry name" value="PyrdxlP_homeostasis"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00044">
        <property type="entry name" value="YggS family pyridoxal phosphate-dependent enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146">
        <property type="entry name" value="PROLINE SYNTHETASE CO-TRANSCRIBED BACTERIAL HOMOLOG PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10146:SF14">
        <property type="entry name" value="PYRIDOXAL PHOSPHATE HOMEOSTASIS PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01168">
        <property type="entry name" value="Ala_racemase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004848">
        <property type="entry name" value="YBL036c_PLPDEIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51419">
        <property type="entry name" value="PLP-binding barrel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01211">
        <property type="entry name" value="UPF0001"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 2" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alanine racemase N-terminal" evidence="4">
        <location>
            <begin position="36"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="modified residue" description="N6-(pyridoxal phosphate)lysine" evidence="2">
        <location>
            <position position="42"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR004848-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01168"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="245" mass="28034" checksum="B2E0771440AC0993" modified="2005-04-12" version="1" fragment="single">GENILFKMSENEVIDNYMKIKNQIKELCSGFESFPELLVVSKYQSEENIKLLHEKTDQKIFGENYVQELMEKSRNLPKSIKWHFIGHLQSNKVKTLLSIDNLEVIETVDSIKLAQVLNKECQLQGRSVLKVMIQVKTSNEVNKSGAQISEAINIFEYIISECRNLKFQGLMTMGDSDVNLTSECFNKMVNLRNIINEKISKNGNYDQSIECRLSMGTTRDMEIAIKNHTNEVRIGSAIFGDKKKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS67</accession>
    <name>Q5CS67_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide containing large protein with proline stretches</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_40</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
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                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
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                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
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</entry>
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            <dbReference type="PubMed" id="15044751"/>
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    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88551.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628139.1">
        <property type="nucleotide sequence ID" value="XM_628139.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSC8"/>
    <dbReference type="STRING" id="353152.Q5CSC8"/>
    <dbReference type="GeneID" id="3371451"/>
    <dbReference type="KEGG" id="cpv:cgd1_3230"/>
    <dbReference type="InParanoid" id="Q5CSC8"/>
    <dbReference type="OMA" id="DEMANHE"/>
    <dbReference type="OrthoDB" id="439212at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346">
        <property type="entry name" value="MAP/MICROTUBULE AFFINITY-REGULATING KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24346:SF30">
        <property type="entry name" value="MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="44"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="611"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="611"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="623"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88551.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="879" mass="98037" checksum="11B263F74D3A602F" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSD9</accession>
    <name>Q5CSD9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Peptide synthase like condensation domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_3120</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628128.1">
        <property type="nucleotide sequence ID" value="XM_628128.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSD9"/>
    <dbReference type="GeneID" id="3371469"/>
    <dbReference type="KEGG" id="cpv:cgd1_3120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3120"/>
    <dbReference type="InParanoid" id="Q5CSD9"/>
    <dbReference type="OMA" id="HIANSPR"/>
    <dbReference type="OrthoDB" id="342498at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003824">
        <property type="term" value="F:catalytic activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.559.10">
        <property type="entry name" value="Chloramphenicol acetyltransferase-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052058">
        <property type="entry name" value="Alcohol_O-acetyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023213">
        <property type="entry name" value="CAT-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001242">
        <property type="entry name" value="Condensation_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR28037:SF1">
        <property type="entry name" value="ALCOHOL O-ACETYLTRANSFERASE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00668">
        <property type="entry name" value="Condensation"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52777">
        <property type="entry name" value="CoA-dependent acyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Condensation" evidence="2">
        <location>
            <begin position="31"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="311"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="581" mass="66259" checksum="57FF660B61194543" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSE2</accession>
    <name>Q5CSE2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88338.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628125.1">
        <property type="nucleotide sequence ID" value="XM_628125.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSE2"/>
    <dbReference type="GeneID" id="3371706"/>
    <dbReference type="KEGG" id="cpv:cgd1_3090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3090"/>
    <dbReference type="InParanoid" id="Q5CSE2"/>
    <dbReference type="OMA" id="HGNLVCG"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="196"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="20"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="93"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="152"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="210"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="225"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="255"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="299"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="387"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88338.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="408" mass="48712" checksum="96B52FEFC433253B" modified="2005-04-12" version="1">MSSRDHRRRGESSFKGGGFNSSKASRSSSNSSYDRRRYSSAKTNTRQKFKSSSRSMSKSSSENRYRSESMSLSNSRSNSRSCPRAGSRQVQRKSIERGRSKERVKRNYESSPEEFNDGYYHRHHYNHQRQDERDFSHSRRSQKLRSVSSSGDRIENRGRAHERSEFKYLRSNVKNHSRITTTQRVGDEDYELNNITTYSHSKSVPGPINSSRSTSRSRSPSIKTNKSENKNDGRNKIRDKVRQRDRDFDKECNRSKSRSVSRSRHSSRSKHISESQNKYKSKSNPRTRSYSCSDEEYISNSNTKTSRNRSQYYRNENYYDQGYDNDYAINKNSEYGNRPSHGYNYDHGNSHYNDYERDSYNHGDRNWNNIRYLNRYRDRHENYVNRSFSEERERSRERERRRRRMQAK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSV4</accession>
    <name>Q5CSV4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_1190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627963.1">
        <property type="nucleotide sequence ID" value="XM_627963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSV4"/>
    <dbReference type="GeneID" id="3371602"/>
    <dbReference type="KEGG" id="cpv:cgd1_1190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1190"/>
    <dbReference type="InParanoid" id="Q5CSV4"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="107" mass="12944" checksum="87177D80552C6F2B" modified="2005-04-12" version="1">MCFPGYKKKWGVSEGMHIRSFNLKIFLFKKNFGLCIFSNSSLFYVDKNYSNMHADFYMQNFTRNTFIANIACNCRYRRAFTKKSEKKLINQLNLKKYRNRLFLKLYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSY3</accession>
    <name>Q5CSY3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS19 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627934.1">
        <property type="nucleotide sequence ID" value="XM_627934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSY3"/>
    <dbReference type="FunCoup" id="Q5CSY3">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSY3"/>
    <dbReference type="GeneID" id="3371371"/>
    <dbReference type="KEGG" id="cpv:cgd1_850"/>
    <dbReference type="InParanoid" id="Q5CSY3"/>
    <dbReference type="OMA" id="WAPFVKT"/>
    <dbReference type="OrthoDB" id="428974at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000118">
        <property type="entry name" value="40S ribosomal protein S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001266">
        <property type="entry name" value="Ribosomal_eS19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11710:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01090">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01413">
        <property type="entry name" value="Ribosomal_S19e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="154" mass="17365" checksum="D13B4B0E9CE96547" modified="2005-04-12" version="1" fragment="single">WFERMTLYETAAPRVIKTAKDVPAGILIEKFAQQLKKGGKMTMPEWVDHVKTASSKELPPQNSDWLYIRAASILRHLYVRPNVGVGALSKFYGRKQRNGTARNHSAVASRGIIRYCLIQLQSLGLVEFNPNTGTRRLSPQGQRELDSIARQCKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSZ1</accession>
    <name>Q5CSZ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_770</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627926.1">
        <property type="nucleotide sequence ID" value="XM_627926.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSZ1"/>
    <dbReference type="FunCoup" id="Q5CSZ1">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="GeneID" id="3371534"/>
    <dbReference type="KEGG" id="cpv:cgd1_770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_770"/>
    <dbReference type="InParanoid" id="Q5CSZ1"/>
    <dbReference type="OMA" id="NIATHRF"/>
    <dbReference type="OrthoDB" id="339907at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="494" mass="58086" checksum="7B5DDE1BA1764A03" modified="2005-04-12" version="1">MKVETTPQEHKGKINLDKGQQLRILSSNSHNGGEQALSHKVREKLSLEQVQKLKDLLVNREYSQSLELLLEYYYNGSIIESWMESLIPEKINYKYVNNELKDSPDFHLYDISGIIILSYIIHCYICKNDIFGAIQLIKSFERACFILKIGENDKNHQSDVVDNVNSHFISWCNCFSIRDVFQENKGIIKHELRSRKHFLKLIDIYYFFRIQIIFWKLAMYKTYHIPNASVFLPENKHGKDLSENIKIEDYFVFFDQAIDELYVIINEIDYILELFKDFDKQVTNKWLLKYKVVLFILVEALTLRDYYNEAIQILNDSMQKHFPDDISLYSLIARISLQYGNFPLVHSTLNTIEERLQHPKHNTNFNIAHYRFTLGLLNMAQDDPVTASLNFNTSAALYKELAINFNKEYLLPCSTSFNNLSVASFYSSKLPNSVSILENQIYNQNNFFFNSQQLFATNFKNLKTLYQFSSDKDKLINELKKISKSSLRYSIMIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT17</accession>
    <name>Q5CT17_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein kinase, CMGC/MAPK group</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627900.1">
        <property type="nucleotide sequence ID" value="XM_627900.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT17"/>
    <dbReference type="STRING" id="353152.Q5CT17"/>
    <dbReference type="GeneID" id="3371417"/>
    <dbReference type="KEGG" id="cpv:cgd1_400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_400"/>
    <dbReference type="InParanoid" id="Q5CT17"/>
    <dbReference type="OMA" id="SICINFR"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044773">
        <property type="term" value="P:mitotic DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167">
        <property type="entry name" value="OVARIAN-SPECIFIC SERINE/THREONINE-PROTEIN KINASE LOK-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44167:SF30">
        <property type="entry name" value="PHOSPHORYLASE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254361" evidence="1">
        <location>
            <begin position="29"/>
            <end position="728"/>
        </location>
    </feature>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="246"/>
            <end position="727"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="728" mass="84305" checksum="923F80CE740E37F3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT69</accession>
    <name>Q5CT69_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein with several coiled coil regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_4210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88894.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626600.1">
        <property type="nucleotide sequence ID" value="XM_626600.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT69"/>
    <dbReference type="GeneID" id="3373691"/>
    <dbReference type="KEGG" id="cpv:cgd2_4210"/>
    <dbReference type="InParanoid" id="Q5CT69"/>
    <dbReference type="OMA" id="ECRHLER"/>
    <dbReference type="OrthoDB" id="340904at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="57"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88894.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="451" mass="51992" checksum="274BE8F13D71D205" modified="2005-04-12" version="1" fragment="single">YIINFQFLTGEMQKRKKKWKLAFCNAQECVNALDYMLENSLETLLNKQEKLRVVEGLSEREKELNIKQNELNSALNEVEEGLRKTIELTLLEMKELSEECRHLEREFTKKASNIPNIIENLNKNDTKFDSEYLGKKVTVEDIQKLQNTRKQLLEDLEQLRKDEETLNKEIQNLEIKWNAYRKRTQRLETEISLKKTETNHQAIQVDAHINRRLSTCNSIRSDKDNDPNIMEVDVIQEQMGTRRKRRDSVVKWIGRLSMNSSSEEKTNQLCDHELVTNNVKEGTKIDKSDNNNDIEDRDEEVQGELQVLNLLSLVKIEQPESDETLTSKAGPPSSTLKLKVDPSPLLSQFLDPNFVYCSDLQPINVDKENSRKSNQGLFSKGALDFSLKVRNQCDGSKSLEEISLCSQNQDAPEKSLNNEDIALFNIFVGELQRNENIPVSSIGKLLCSTLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTA4</accession>
    <name>Q5CTA4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88650.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626565.1">
        <property type="nucleotide sequence ID" value="XM_626565.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTA4"/>
    <dbReference type="GeneID" id="3373408"/>
    <dbReference type="KEGG" id="cpv:cgd2_3800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3800"/>
    <dbReference type="InParanoid" id="Q5CTA4"/>
    <dbReference type="OrthoDB" id="342564at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="265"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="298"/>
            <end position="307"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88650.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="369" mass="43051" checksum="3CA99796E6E041E2" modified="2005-04-12" version="1">MEYFDDDIISNMNRMEINKRPNIFDDLLGGDDETEKVNEEEDIFSVDEKRISNSESLFNSSYNKERNPFEDENREDEVIFGIERKREDEIGDKVDIMKSNQKRISNAFAMVGGIDFHEFNNNLNGNEFNDDFEMDNKFESNEDIFSLSRSNRKTNNGEDERYEEEEEKKIGLVQGEEDILLQKEEAYYREEKDPEQIIETKKNSISENLFGIQEEKQINKGNFNIENETPGNKELQFENPPLNNYENANPYIQNNKNLNELSCDKENELVPPGKSERKKSETNISDHNPLCESKEETNNNSLDKNNSETCVESNKIKVNNNLQSSLEDIDWNRVSKIIENFEKQTGNSGRNQMLFKSIIYKLANKNGNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTB2</accession>
    <name>Q5CTB2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_3720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626557.1">
        <property type="nucleotide sequence ID" value="XM_626557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTB2"/>
    <dbReference type="GeneID" id="3373618"/>
    <dbReference type="KEGG" id="cpv:cgd2_3720"/>
    <dbReference type="InParanoid" id="Q5CTB2"/>
    <dbReference type="OrthoDB" id="344189at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="133" mass="15746" checksum="4059E49C2C5F6BFC" modified="2005-04-12" version="1">MADQQDVEMAQSDHQNVPDTINELVLKEEKNISEKSKIKEYCKSVLEKDLDHSINCDIIDQSEVSEFRSQVNKMKMWPSFDHIFKAARRDNKWYLRSQPLRGINKILFEEQKLINISKVRNLAIICFFFLLII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTF6</accession>
    <name>Q5CTF6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Sc6p-like, SM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_3220</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626513.1">
        <property type="nucleotide sequence ID" value="XM_626513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTF6"/>
    <dbReference type="FunCoup" id="Q5CTF6">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTF6"/>
    <dbReference type="GeneID" id="3373555"/>
    <dbReference type="KEGG" id="cpv:cgd2_3220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3220"/>
    <dbReference type="InParanoid" id="Q5CTF6"/>
    <dbReference type="OMA" id="WYPPPGH"/>
    <dbReference type="OrthoDB" id="21539at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01736">
        <property type="entry name" value="LSm14_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025762">
        <property type="entry name" value="DFDF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019050">
        <property type="entry name" value="FDF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025761">
        <property type="entry name" value="FFD_box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025609">
        <property type="entry name" value="Lsm14-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025768">
        <property type="entry name" value="TFG_box"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586">
        <property type="entry name" value="SCD6 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13586:SF0">
        <property type="entry name" value="TRAILER HITCH, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12701">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01199">
        <property type="entry name" value="FDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01271">
        <property type="entry name" value="LSM14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51512">
        <property type="entry name" value="DFDF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51513">
        <property type="entry name" value="FFD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51536">
        <property type="entry name" value="TFG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Sm" evidence="7">
        <location>
            <begin position="1"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="domain" description="DFDF" evidence="4">
        <location>
            <begin position="207"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="domain" description="FFD box profile" evidence="5">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="domain" description="TFG box profile" evidence="6">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="80"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="239"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="305"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="FFD box" evidence="1">
        <location>
            <begin position="289"/>
            <end position="305"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="TFG box" evidence="2">
        <location>
            <begin position="321"/>
            <end position="341"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="100"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="111"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="126"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="148"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="176"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="324"/>
            <end position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00869"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51512"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="377" mass="40082" checksum="1564E181EB065182" modified="2005-04-12" version="1">MVHEYIGSKITIISRNDKRYEGVLHSIDVDKSTITLKDVRYFENGPNGAPGPASSTVFEMIVFRGSDITDLAVCQPAAATNNNGLPNDPAILSVNGGSGTTSAQSQGQSHVADTSSVNQQKPLETSSSNSRRSPKMSYSNAVSGGKPSGTNQGSSSISNGRKDHSRNRQRGGGYSGKSYKGSGGSSHYNNGGGSQRSFIVGELKPRINQALKAELDTEFDFSEQNKKFEKTLNEGLASAQTEQGVKLEGTISDTGNKSGAMNTGLGISGNSNASNDTTDDDPSKKLTVGGYNKVSGFFDSISCETLDPERSKKPQGSSDPQAKALREKQKQIDKETFGTSAVKPRTGSYNRGSHHRRGGGSHRGGYHGNNRFNKREA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTF8</accession>
    <name>Q5CTF8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 8">Glucose-6-phosphate isomerase</fullName>
            <ecNumber evidence="3 8">5.3.1.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_3200</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7 8">
            <text>alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate</text>
            <dbReference type="Rhea" id="RHEA:11816"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="ChEBI" id="CHEBI:58225"/>
            <dbReference type="EC" id="5.3.1.9"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 8">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the GPI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.1.9" evidence="3 8"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88696.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626511.1">
        <property type="nucleotide sequence ID" value="XM_626511.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTF8"/>
    <dbReference type="FunCoup" id="Q5CTF8">
        <property type="interactions" value="64"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTF8"/>
    <dbReference type="GeneID" id="3373556"/>
    <dbReference type="KEGG" id="cpv:cgd2_3200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3200"/>
    <dbReference type="InParanoid" id="Q5CTF8"/>
    <dbReference type="OMA" id="DWYRQLW"/>
    <dbReference type="OrthoDB" id="5831190at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00181"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097367">
        <property type="term" value="F:carbohydrate derivative binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004347">
        <property type="term" value="F:glucose-6-phosphate isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048029">
        <property type="term" value="F:monosaccharide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051156">
        <property type="term" value="P:glucose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd05015">
        <property type="entry name" value="SIS_PGI_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05016">
        <property type="entry name" value="SIS_PGI_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1390.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00473">
        <property type="entry name" value="G6P_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001672">
        <property type="entry name" value="G6P_Isomerase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023096">
        <property type="entry name" value="G6P_Isomerase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018189">
        <property type="entry name" value="Phosphoglucose_isomerase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046348">
        <property type="entry name" value="SIS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035476">
        <property type="entry name" value="SIS_PGI_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035482">
        <property type="entry name" value="SIS_PGI_2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001211">
        <property type="entry name" value="PRK00179.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11469:SF1">
        <property type="entry name" value="GLUCOSE-6-PHOSPHATE ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00342">
        <property type="entry name" value="PGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00662">
        <property type="entry name" value="G6PISOMERASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53697">
        <property type="entry name" value="SIS domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00765">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00174">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51463">
        <property type="entry name" value="P_GLUCOSE_ISOMERASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0312">Gluconeogenesis</keyword>
    <keyword evidence="5 8" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 8 9" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011952"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029321"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88696.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="567" mass="63212" checksum="C8522B3701758071" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTJ7</accession>
    <name>Q5CTJ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TrmA RNA methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_2710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="4">Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88906.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626472.1">
        <property type="nucleotide sequence ID" value="XM_626472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTJ7"/>
    <dbReference type="STRING" id="353152.Q5CTJ7"/>
    <dbReference type="GeneID" id="3373668"/>
    <dbReference type="KEGG" id="cpv:cgd2_2710"/>
    <dbReference type="InParanoid" id="Q5CTJ7"/>
    <dbReference type="OMA" id="TPLWNMP"/>
    <dbReference type="OrthoDB" id="10250660at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.1070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025714">
        <property type="entry name" value="Methyltranfer_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030390">
        <property type="entry name" value="MeTrfase_TrmA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045850">
        <property type="entry name" value="TRM2_met"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010280">
        <property type="entry name" value="U5_MeTrfase_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45904:SF2">
        <property type="entry name" value="TRNA (URACIL-5-)-METHYLTRANSFERASE HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13847">
        <property type="entry name" value="Methyltransf_31"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51687">
        <property type="entry name" value="SAM_MT_RNA_M5U"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01230">
        <property type="entry name" value="TRMA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Methyltransferase" evidence="7">
        <location>
            <begin position="352"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="active site" evidence="5">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="319"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="391"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="4">
        <location>
            <position position="441"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF13847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88906.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="550" mass="62742" checksum="8EF50D70FF9C42C5" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTP3</accession>
    <name>Q5CTP3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Proteasome regulatory subunit Rpn7/26S proteasome subunit 6, PINT domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_2210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88775.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626426.1">
        <property type="nucleotide sequence ID" value="XM_626426.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTP3"/>
    <dbReference type="FunCoup" id="Q5CTP3">
        <property type="interactions" value="543"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTP3"/>
    <dbReference type="GeneID" id="3373519"/>
    <dbReference type="KEGG" id="cpv:cgd2_2210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2210"/>
    <dbReference type="InParanoid" id="Q5CTP3"/>
    <dbReference type="OMA" id="RLHCKVD"/>
    <dbReference type="OrthoDB" id="1452at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.570:FF:000005">
        <property type="entry name" value="26S proteasome regulatory subunit N7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019585">
        <property type="entry name" value="Rpn7/CSN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045135">
        <property type="entry name" value="Rpn7_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049549">
        <property type="entry name" value="RPN7_PSMD6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14145">
        <property type="entry name" value="26S PROTESOME SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10602">
        <property type="entry name" value="RPN7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21154">
        <property type="entry name" value="RPN7_PSMD6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 4" id="KW-0647">Proteasome</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="3">
        <location>
            <begin position="190"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="87"/>
            <end position="114"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88775.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="403" mass="47439" checksum="592B60ACBD140ED4" modified="2005-04-12" version="1">MGIGNKLKEVLDLSMNPEELLQSVPDLKLSEKICQLDSKYCKFGEKESMKNEILSYIKKNSMAPLFKILSKDIKILDNDEKFLDVLIEDNNSELNEINEKIKDARENYGDVEVRNCHYKKLVFYSRIGSKEKSLQELEVAIEKTIGGFKLELLFLGIRTGFFWNDLNLISKYIKRAEDLFKTTSDWERKNRFKVYKAIYYLITRNFSAASELFLDSLTTFTAAELISFDRLIFYTIVSSIISIDRRTIKSKLLTSPDILKIALQPDNKFLLEFIESFYYGRYSQFFERLVNITYILQKDYYFNRHHKYYLRIVRSKAYIQYLEPYESVSILSMAESFGITQEFLEKDIVTFISSSKLSCTIDKVKQVIICSRNDKKINQYNELVQKGDLLLNRLQRLTRIIQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTR7</accession>
    <name>Q5CTR7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1920</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626402.1">
        <property type="nucleotide sequence ID" value="XM_626402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTR7"/>
    <dbReference type="GeneID" id="3373736"/>
    <dbReference type="KEGG" id="cpv:cgd2_1920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1920"/>
    <dbReference type="InParanoid" id="Q5CTR7"/>
    <dbReference type="OMA" id="CLEISIN"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1140" mass="133561" checksum="CD98CA22A5204B86" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTS7</accession>
    <name>Q5CTS7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1730</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88803.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626392.1">
        <property type="nucleotide sequence ID" value="XM_626392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTS7"/>
    <dbReference type="GeneID" id="3373744"/>
    <dbReference type="KEGG" id="cpv:cgd2_1730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1730"/>
    <dbReference type="InParanoid" id="Q5CTS7"/>
    <dbReference type="OMA" id="LNSETIW"/>
    <dbReference type="OrthoDB" id="339006at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88803.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="408" mass="47134" checksum="4E75D2E99ED9BA3A" modified="2005-04-12" version="1">MHCFIWGKKKKLIYSTAFLIILENWNLNMFELEKLLASYSHPILRERIEYFGRFQQDILDSNYPNIASFNLLEQGNETIFDYDGFVYKLYLSFASNTEVNKKNNTSENKENDLKIVPLKDIRRESSKHLNLVIEVYNTHIRQLWNDAKQLIEHYKSIISNAIEIYESHNLDNCLIIYLPNNAISEIFSDLNNRNATKSAAFEMITSSIKSCLYCGSVLNTIRYISFYCFLDNKTISEDIGIQGFSLIYITLLSNKKIYAFYPDSKNKYKFAILAIEFLDKLIKSNILTSNFIQELSIAINQSEISIFKNMLDSNAISISYSSSLPKSANEILYNQKSDSSSGEKSFMIFCIPISWLDSTDDYIKLYFAGLITLINNILLQMIPQCKSTIRCGLRKFVLELTSQECEGC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTS8</accession>
    <name>Q5CTS8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88804.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626391.1">
        <property type="nucleotide sequence ID" value="XM_626391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTS8"/>
    <dbReference type="GeneID" id="3373745"/>
    <dbReference type="KEGG" id="cpv:cgd2_1720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1720"/>
    <dbReference type="InParanoid" id="Q5CTS8"/>
    <dbReference type="OMA" id="NEFTHGM"/>
    <dbReference type="OrthoDB" id="1661054at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88804.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="599" mass="69800" checksum="485AA461B2A07F75" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTV3</accession>
    <name>Q5CTV3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Dynactin subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd2_1430</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="13">Subunit of dynactin, a multiprotein complex part of a tripartite complex with dynein and a adapter, such as BICDL1, BICD2 or HOOK3. The dynactin complex is built around ACTR1A/ACTB filament and consists of an actin-related filament composed of a shoulder domain, a pointed end and a barbed end. Its length is defined by its flexible shoulder domain. The soulder is composed of 2 DCTN1 subunits, 4 DCTN2 and 2 DCTN3. The 4 DCNT2 (via N-terminus) bind the ACTR1A filament and act as molecular rulers to determine the length. The pointed end is important for binding dynein-dynactin cargo adapters. Consists of 4 subunits: ACTR10, DCNT4, DCTN5 and DCTN6. The barbed end is composed of a CAPZA1:CAPZB heterodimers, which binds ACTR1A/ACTB filament and dynactin and stabilizes dynactin. Interacts with ATP7B, but not ATP7A, in a copper-dependent manner. Interacts with ANK2; this interaction is required for localization at costameres. Interacts with N4BP2L1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
            <location evidence="1">Microtubule organizing center</location>
            <location evidence="1">Centrosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Stress fiber</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
            <location evidence="3">Myofibril</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the dynactin subunit 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88826.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626366.1">
        <property type="nucleotide sequence ID" value="XM_626366.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTV3"/>
    <dbReference type="STRING" id="353152.Q5CTV3"/>
    <dbReference type="GeneID" id="3373728"/>
    <dbReference type="KEGG" id="cpv:cgd2_1430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1430"/>
    <dbReference type="InParanoid" id="Q5CTV3"/>
    <dbReference type="OMA" id="RTRCINE"/>
    <dbReference type="OrthoDB" id="283815at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005813">
        <property type="term" value="C:centrosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001725">
        <property type="term" value="C:stress fiber"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008603">
        <property type="entry name" value="DCTN4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034">
        <property type="entry name" value="DYNACTIN P62 SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13034:SF2">
        <property type="entry name" value="DYNACTIN SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05502">
        <property type="entry name" value="Dynactin_p62"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0007">Acetylation</keyword>
    <keyword evidence="9 14" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0832">Ubl conjugation</keyword>
    <feature type="coiled-coil region" evidence="14">
        <location>
            <begin position="164"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004300"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022843"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00093507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK88826.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="460" mass="53433" checksum="31398B01123E6377" modified="2005-04-12" version="1">MHSSNVFYLVNGENHDLINCYYCESCNKLISQEEVKIEVDTYFCPSCLENVPSSEAFSRNFRCINCHDCPKCMATISTNKLDLGPEIDENNGRIMQHSYNCGFCHFSLNVNLEMDAGNETDEKTMNESNDENNKLHIHKQNDSLFLQESNYLSLIIDKVKNSAYKHFNTNISSETKQLNNLNDEQSELNLSLRILEEKQKTSASLREKNIWLNSDKMKYLSNIRELLPTCLKKNDLSYRQYINNPDIINSVYLSLRANSNSQTKLCPYMKKLSVQISKRCMACKRLVIKPQLNPLSQPPFRVNLSANLFFPNFRIVSIKDNSSGDRSFTKIIKIRTENLMDRQVRIDFLPERDQNEQLSIENSKVYSIFKIEPKSFTLEPKWDPLLEQQSQQSNSFAHERRSRNRKYLDVFIFESADIRDKIELELTAFTNFQSPTGNESTVQIKLIGKANIQDENYTTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTV5</accession>
    <name>Q5CTV5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible domain KOG3410, conserved alpha-helical protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88824.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626364.1">
        <property type="nucleotide sequence ID" value="XM_626364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTV5"/>
    <dbReference type="STRING" id="353152.Q5CTV5"/>
    <dbReference type="GeneID" id="3373726"/>
    <dbReference type="KEGG" id="cpv:cgd2_1410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1410"/>
    <dbReference type="InParanoid" id="Q5CTV5"/>
    <dbReference type="OrthoDB" id="205403at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013865">
        <property type="entry name" value="FAM32A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13282:SF6">
        <property type="entry name" value="PROTEIN FAM32A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88824.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="142" mass="16186" checksum="76B7B99364D33146" modified="2005-04-12" version="1">MSKDEQKKIDSSYDNVIKKPIKLLKYKNSNSKLGIKSNEKNLVQTNKLANNLSCEKNFPESLFNHSTPNDDAKLLVPNPIAGIDKTTGYTKAELSHKEAQRKRVHKQIEFRASLTHRQRVSKFNEKLSMLPEHFDIPKVGPG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTY2</accession>
    <name>Q5CTY2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">O-acyltransferase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_1090</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 10">Endoplasmic reticulum membrane</location>
            <topology evidence="1 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626337.1">
        <property type="nucleotide sequence ID" value="XM_626337.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTY2"/>
    <dbReference type="FunCoup" id="Q5CTY2">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTY2"/>
    <dbReference type="GeneID" id="3373594"/>
    <dbReference type="KEGG" id="cpv:cgd2_1090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1090"/>
    <dbReference type="InParanoid" id="Q5CTY2"/>
    <dbReference type="OMA" id="RCHDYRR"/>
    <dbReference type="OrthoDB" id="10039049at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004144">
        <property type="term" value="F:diacylglycerol O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019432">
        <property type="term" value="P:triglyceride biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004299">
        <property type="entry name" value="MBOAT_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014371">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408:SF7">
        <property type="entry name" value="DIACYLGLYCEROL O-ACYLTRANSFERASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10408">
        <property type="entry name" value="STEROL O-ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03062">
        <property type="entry name" value="MBOAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000439">
        <property type="entry name" value="Oat_ACAT_DAG_ARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10 13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6 10" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8 10 12" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10 13" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 12" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="38"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="79"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="161"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="304"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="379"/>
            <end position="401"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="438"/>
            <end position="462"/>
        </location>
    </feature>
    <feature type="active site" evidence="11">
        <location>
            <position position="397"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR000439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR000439-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="505" mass="58554" checksum="9560C6D68CAF3806" modified="2005-04-12" version="1">MKNSGVDYRGRPLFDIPHKMASTTILSKNSADLNLKGFFNLFILILVFTNMGVVLENAMKYGCKVSFPKGITDLIQNWPILWCICQLLALVFVSYLLEKYLASLKIFLLNIYDCEPNSNSNQANCGFAHSSLPKITGGLSLVLIMINMLMMLYIPYKTVKFYSPNPLSSLILLSFSFVWFFKTLSFHHVCHDVRRCILNNEDFHEVCGTSPEAEIASKYPTSLSLRYHYWFLMAPTMCFQFWYPRTGGIRWLQVIKHTIELITCIILIKIITEQYVMVTAHYTFTLKEIQSMNIFQFLGHMATRIMKLSIPSLYVWLLGFVSLFHHYLNILGEITCFADRAFYLDWWNAGNFGEYWRKWNLPVHFFLTRHIFKPLRKKGFSSSFSGLLVFTFSALIHEYLVVVPLDIGWTGWVVLAFVFQVPLSSWTQSSYIQKRETLGNVLFWITFCFCGQPIAVLLYYYLWALSKGQIDQIDLNKIEGIPQIPLENISGYIANLTNVTHNIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU50</accession>
    <name>Q5CU50_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Secreted insulinase like peptidase, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_4210</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626964.1">
        <property type="nucleotide sequence ID" value="XM_626964.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU50"/>
    <dbReference type="STRING" id="353152.Q5CU50"/>
    <dbReference type="GeneID" id="3373889"/>
    <dbReference type="KEGG" id="cpv:cgd3_4210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4210"/>
    <dbReference type="InParanoid" id="Q5CU50"/>
    <dbReference type="OMA" id="ENAFIEM"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254407" evidence="3">
        <location>
            <begin position="18"/>
            <end position="1254"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="4">
        <location>
            <begin position="275"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="946"/>
            <end position="976"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="962"/>
            <end position="976"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1254" mass="144576" checksum="E6C0AB2835485E46" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU62</accession>
    <name>Q5CU62_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved protein with UAS domain, possible ubiquitin protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_4080</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89235.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626952.1">
        <property type="nucleotide sequence ID" value="XM_626952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU62"/>
    <dbReference type="FunCoup" id="Q5CU62">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU62"/>
    <dbReference type="GeneID" id="3374009"/>
    <dbReference type="KEGG" id="cpv:cgd3_4080"/>
    <dbReference type="InParanoid" id="Q5CU62"/>
    <dbReference type="OMA" id="IFMNTYK"/>
    <dbReference type="OrthoDB" id="270602at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043130">
        <property type="term" value="F:ubiquitin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043161">
        <property type="term" value="P:proteasome-mediated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02958">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14351">
        <property type="entry name" value="UBA_Ubx1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006577">
        <property type="entry name" value="UAS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050730">
        <property type="entry name" value="UBX_domain-protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322">
        <property type="entry name" value="FAS-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23322:SF6">
        <property type="entry name" value="UBX DOMAIN-CONTAINING PROTEIN 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13899">
        <property type="entry name" value="Thioredoxin_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14555">
        <property type="entry name" value="UBA_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00594">
        <property type="entry name" value="UAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UAS" evidence="2">
        <location>
            <begin position="122"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="261"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="296"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="300"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00594"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89235.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="342" mass="38941" checksum="14494B0AA8A4FF69" modified="2005-04-12" version="1" fragment="single">FHHYLILLDNINMVSNEEIENFINISGCTDSQIAKMYLEMYPGDMNSAINEYFSNLGNETTSNINNSNPGNNLFHDEEDVRTPIPSFNDQLIPDDHNALNSSQFMQNGRVVHTDDLLPPVDDFSTQMFSPPQIIMFCEPFEIAKEKAKSQKKLILVNIQSPNEFSSMILNRDIWNDSLIIEFIQEHFIFWQRSSNTPEGNEWLNLYNISKLPHVSVVDPRTGRQLKVWDVAKSFSDSISASSEIIEFLESENTLRAFNRMSTNSNSTSHEATNSILPNVSNQTSDSFITNTSISTTQAPQDTLSSQDSLQSQSNTQVQVPTINSELAMLHMERMRRKNSEKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV89</accession>
    <name>Q5CV89_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_4980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627380.1">
        <property type="nucleotide sequence ID" value="XM_627380.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV89"/>
    <dbReference type="GeneID" id="3374202"/>
    <dbReference type="KEGG" id="cpv:cgd8_4980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4980"/>
    <dbReference type="InParanoid" id="Q5CV89"/>
    <dbReference type="OrthoDB" id="1938039at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="27"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="27"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="126" mass="14575" checksum="F87448715CB90B8D" modified="2005-04-12" version="1">MQSNSEFAKDSSSFDTSQFAIWELNQASTSPVSPTSSNLTDSEYQLNPLTPTSDPSDPKLEFRCSSCEIYLRRMHGLENELQILTNNIYCLFKTAKEEIQRKDKLIQEKDELIKQLKKTKTKQYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVC6</accession>
    <name>Q5CVC6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627343.1">
        <property type="nucleotide sequence ID" value="XM_627343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVC6"/>
    <dbReference type="GeneID" id="3374442"/>
    <dbReference type="KEGG" id="cpv:cgd8_4580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4580"/>
    <dbReference type="InParanoid" id="Q5CVC6"/>
    <dbReference type="OMA" id="EYQSKIH"/>
    <dbReference type="OrthoDB" id="343329at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="89"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="150"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="326"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="527" mass="62382" checksum="EC293025013FA36E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVG0</accession>
    <name>Q5CVG0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized glycine-rich low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89563.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627309.1">
        <property type="nucleotide sequence ID" value="XM_627309.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVG0"/>
    <dbReference type="GeneID" id="3374193"/>
    <dbReference type="KEGG" id="cpv:cgd8_4190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4190"/>
    <dbReference type="InParanoid" id="Q5CVG0"/>
    <dbReference type="OrthoDB" id="2017893at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="228"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="243"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89563.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="267" mass="30439" checksum="D8CE4CFDA38CC310" modified="2005-04-12" version="1">MIRREEKVRRDTLNKTINKSDNNNINYHKNENGLLSSLNTNITPLMQLKEKLKELKNKPRDEIFTSLKLIERDFKLIQELFTEHVKRFSIIYNQGIGITGTQTNGVKEVEQEQGEIESKRLEKQFIQVDNSNICHSNLMMMNNMNEGVSSMVINSQINKSQLEQLQQNYLQNLIGNQIQVKNNMISSNLNVPTGIINSSLSSSSQISSNMNSNITTTSRNIISHPYYIQKQPNTNKNNPSSSLAEXXGXXVNXXXXXXIXXEXXNXX</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVJ3</accession>
    <name>Q5CVJ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_3840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627276.1">
        <property type="nucleotide sequence ID" value="XM_627276.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVJ3"/>
    <dbReference type="GeneID" id="3374254"/>
    <dbReference type="KEGG" id="cpv:cgd8_3840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3840"/>
    <dbReference type="InParanoid" id="Q5CVJ3"/>
    <dbReference type="OMA" id="DEWYESI"/>
    <dbReference type="OrthoDB" id="339652at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="206" mass="23840" checksum="149BB9DBF939CBD2" modified="2005-04-12" version="1">MGLISREIRRLLYNPLIDLLRLIEVWSKYRLELQKSVQKYSALKIESAYLNQKSCLCLNMFSLNQSYISGSAEAIQDQLNHSKNLAIEKMQEISQIQSGIDEIYTHLSSFTETYNEMIYSSIIGGSSSGISVDIVLDFLCEWKDCIESDIKVQNKIFNLIEKLKSYHTRNIQACLSYFQCSPYGDILEGKENYINLKKCLREFITQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVN8</accession>
    <name>Q5CVN8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SPAC1687.04-like conserved eukaryotic protein that shares a domain with several MCM7, probably involved in DNA replication</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627231.1">
        <property type="nucleotide sequence ID" value="XM_627231.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVN8"/>
    <dbReference type="STRING" id="353152.Q5CVN8"/>
    <dbReference type="GeneID" id="3374298"/>
    <dbReference type="KEGG" id="cpv:cgd8_3360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3360"/>
    <dbReference type="InParanoid" id="Q5CVN8"/>
    <dbReference type="OMA" id="ESALICY"/>
    <dbReference type="OrthoDB" id="329666at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019140">
        <property type="entry name" value="MCM_complex-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13489:SF0">
        <property type="entry name" value="MINI-CHROMOSOME MAINTENANCE COMPLEX-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09739">
        <property type="entry name" value="MCM_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="593" mass="68922" checksum="FCA8872B8F3039A8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVP0</accession>
    <name>Q5CVP0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">PWI domain containing protein that is typically seen in spliceosomal proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627229.1">
        <property type="nucleotide sequence ID" value="XM_627229.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVP0"/>
    <dbReference type="STRING" id="353152.Q5CVP0"/>
    <dbReference type="GeneID" id="3374297"/>
    <dbReference type="KEGG" id="cpv:cgd8_3340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3340"/>
    <dbReference type="InParanoid" id="Q5CVP0"/>
    <dbReference type="OrthoDB" id="163257at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1390.10">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002483">
        <property type="entry name" value="PWI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036483">
        <property type="entry name" value="PWI_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01480">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00311">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101233">
        <property type="entry name" value="PWI domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51025">
        <property type="entry name" value="PWI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PWI" evidence="2">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="316" mass="36631" checksum="F95BBAF7095825EA" modified="2005-04-12" version="1">MEIFEKKINFNTLPLNKVRRWISSKTEQILGKEDEIFIDYCINQLVYKIRKSAAEEELQISPNELIKNIEGFLGERAIEFVSELWEYISKFSGNPIKIKSSKNHISPRNVAIKKNILRSSDIYNRDKNSLITKNSNINKEIACCHIYKGNASYISAMNNTEDSSKFIPLTSRHSKENKRARSLSRSLSPDLYESYGIKSYKYEKIQKMEENSIIGGISCSKVYTNKSEKKSERFSNINKYITSIDEKASFPDINPLNNCQTALAAPTSEKMQEHNLRMKALELFKRKNQAKNFRSESEEILRARAIEKFIKKKPKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVP2</accession>
    <name>Q5CVP2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phenylalanine--tRNA ligase</fullName>
            <ecNumber evidence="4">6.1.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="13">Phenylalanyl-tRNA synthetase beta subunit</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd8_3320</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.20" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89709.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627227.1">
        <property type="nucleotide sequence ID" value="XM_627227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVP2"/>
    <dbReference type="FunCoup" id="Q5CVP2">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVP2"/>
    <dbReference type="GeneID" id="3374616"/>
    <dbReference type="KEGG" id="cpv:cgd8_3320"/>
    <dbReference type="InParanoid" id="Q5CVP2"/>
    <dbReference type="OMA" id="FPGRCAN"/>
    <dbReference type="OrthoDB" id="1698572at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009328">
        <property type="term" value="C:phenylalanine-tRNA ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004826">
        <property type="term" value="F:phenylalanine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006432">
        <property type="term" value="P:phenylalanyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.40.10:FF:000002">
        <property type="entry name" value="phenylalanine--tRNA ligase beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.10">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.40.10">
        <property type="entry name" value="Phenylalanyl-trna Synthetase, Chain B, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005146">
        <property type="entry name" value="B3/B4_tRNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045060">
        <property type="entry name" value="Phe-tRNA-ligase_IIc_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004531">
        <property type="entry name" value="Phe-tRNA-synth_IIc_bsu_arc_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020825">
        <property type="entry name" value="Phe-tRNA_synthase-like_B3/B4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041616">
        <property type="entry name" value="PheRS_beta_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040659">
        <property type="entry name" value="PhetRS_B1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005147">
        <property type="entry name" value="tRNA_synthase_B5-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00471">
        <property type="entry name" value="pheT_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947:SF0">
        <property type="entry name" value="PHENYLALANINE--TRNA LIGASE BETA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10947">
        <property type="entry name" value="PHENYLALANYL-TRNA SYNTHETASE BETA CHAIN AND LEUCINE-RICH REPEAT-CONTAINING PROTEIN 47"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03483">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03484">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18262">
        <property type="entry name" value="PhetRS_B1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17759">
        <property type="entry name" value="tRNA_synthFbeta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00873">
        <property type="entry name" value="B3_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00874">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51483">
        <property type="entry name" value="B5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 15" id="KW-0436">Ligase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="B5" evidence="14">
        <location>
            <begin position="335"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00007438"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00033189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK89709.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="679" mass="76718" checksum="7D9BDA77CFABE46D" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVY1</accession>
    <name>Q5CVY1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 11">Adenosine kinase</fullName>
            <shortName evidence="11">AK</shortName>
            <ecNumber evidence="4 11">2.7.1.20</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Adenosine 5'-phosphotransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd8_2370</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>adenosine + ATP = AMP + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:20824"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.1.20"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2 11">Purine metabolism; AMP biosynthesis via salvage pathway; AMP from adenosine: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the carbohydrate kinase PfkB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.20" evidence="4 11"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89695.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627138.1">
        <property type="nucleotide sequence ID" value="XM_627138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVY1"/>
    <dbReference type="STRING" id="353152.Q5CVY1"/>
    <dbReference type="GeneID" id="3374392"/>
    <dbReference type="KEGG" id="cpv:cgd8_2370"/>
    <dbReference type="InParanoid" id="Q5CVY1"/>
    <dbReference type="OMA" id="RTMCTYL"/>
    <dbReference type="OrthoDB" id="432447at2759"/>
    <dbReference type="UniPathway" id="UPA00588">
        <property type="reaction ID" value="UER00659"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004001">
        <property type="term" value="F:adenosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044209">
        <property type="term" value="P:AMP salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006144">
        <property type="term" value="P:purine nucleobase metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006166">
        <property type="term" value="P:purine ribonucleoside salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01168">
        <property type="entry name" value="adenosine_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1110.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001805">
        <property type="entry name" value="Adenokinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011611">
        <property type="entry name" value="PfkB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45769:SF3">
        <property type="entry name" value="ADENOSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00294">
        <property type="entry name" value="PfkB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 11" id="KW-0660">Purine salvage</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Carbohydrate kinase PfkB" evidence="12">
        <location>
            <begin position="56"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="337"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010688"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR601805-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU368116"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK89695.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="395" mass="44015" checksum="72CC7C371CDC4724" modified="2005-04-12" version="1" fragment="single">IFNIDLEEMRGKKIFGMCNPILDIVLKASPDRIKDLGLKIGSTTLGNDEEVFKLIGDIISNNEDANFVAGGSLLNAFRVCKELSNKDEKNKDDSISVFFSGGISDDSGGILLQELLTEIGIEFEFHITNKANLETAKCVVFVTEEERTLLAGLGAAKEYSITTFESENIQHALKTANIFATSGFFVEVCFQAILKSAQYIHQFRSNECSFVFGLSATYIPEKYMNELFQLLPMIDYIIGNQEEFVSLYKSINNILQIEDDDQLLLSQDNINQPENDALERILTEIHKHLKPTCIILCTRAHLPVISFNPKDPNSCIKYHECIHVPKERLIDVNGCGDAFKGGLIYGISNSYPLDASIYMGHYAASNVAQNVGCDFDFSNKPTLSEIIQLTSSKNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVZ5</accession>
    <name>Q5CVZ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RCC1 like beta propeller protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_2210</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89692.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627124.1">
        <property type="nucleotide sequence ID" value="XM_627124.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVZ5"/>
    <dbReference type="STRING" id="353152.Q5CVZ5"/>
    <dbReference type="GeneID" id="3374389"/>
    <dbReference type="KEGG" id="cpv:cgd8_2210"/>
    <dbReference type="InParanoid" id="Q5CVZ5"/>
    <dbReference type="OMA" id="ELHENNQ"/>
    <dbReference type="OrthoDB" id="293800at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051625">
        <property type="entry name" value="Signaling_Regulatory_Domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872">
        <property type="entry name" value="BTK-BINDING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22872:SF2">
        <property type="entry name" value="INHIBITOR OF BRUTON TYROSINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="RCC1" evidence="2">
        <location>
            <begin position="89"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89692.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="435" mass="49172" checksum="A83673ABDC57CAD2" modified="2005-04-12" version="1" fragment="single">WSECKGLIDKGSVGKTSMYSSVQNQNTKNEYLITTSDYLLDLSRPVSKKTTVSVYKGINNIETIHTLGKKKIIQVSSGLNHVLFLTSEFEIYSYGTGLFGQLGHGESIQKLKEPKKIQEDIEGVIKITAGTYSSIALTSKGEIYRWGLYDLKSPIVFKPKLETFFGGKNKVVEVESYKEKTCIALDNGEIYAWDFHNPRMELICRLNDTIVKQISIGAYFTLVLDSDSQLFVWGDNTFGEFSENDMYIYDPDFPNFSRLKIEAWGLSTKNSNLKYIKEDELPNNICEDTKIAEGLEGNSREIYIEKITCGEKHCLILTSINSILCMGDNTYGQCGILDDKKSIYPPVTLKKFSELDFLKPFISCGSRSSAIISPTGKLFLCGQLYTNSKSNKKIGVSRYADKIEDFNRLYTEYSIIHRNSSVIDFNDKTFIVISN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW39</accession>
    <name>Q5CW39_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted secrete protein, paralog within GGC gene family of secreted cryptospordium proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89379.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627080.1">
        <property type="nucleotide sequence ID" value="XM_627080.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3374604"/>
    <dbReference type="KEGG" id="cpv:cgd8_1740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1740"/>
    <dbReference type="InParanoid" id="Q5CW39"/>
    <dbReference type="OMA" id="TWIEMAL"/>
    <dbReference type="OrthoDB" id="337940at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255019" evidence="1">
        <location>
            <begin position="28"/>
            <end position="1506"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89379.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1506" mass="168177" checksum="CCE1716001AED07C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWA0</accession>
    <name>Q5CWA0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">HBS1 eRFS. GTpase. (RNA metabolism translation)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_1120</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627019.1">
        <property type="nucleotide sequence ID" value="XM_627019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWA0"/>
    <dbReference type="STRING" id="353152.Q5CWA0"/>
    <dbReference type="GeneID" id="3374565"/>
    <dbReference type="KEGG" id="cpv:cgd8_1120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1120"/>
    <dbReference type="InParanoid" id="Q5CWA0"/>
    <dbReference type="OMA" id="CHIFDLW"/>
    <dbReference type="OrthoDB" id="342024at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050100">
        <property type="entry name" value="TRAFAC_GTPase_members"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23115">
        <property type="entry name" value="TRANSLATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="3">
        <location>
            <begin position="79"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="530" mass="59840" checksum="CA880E88F8571463" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWF9</accession>
    <name>Q5CWF9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">ABC transporter ATpase with 2 AAA domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_5260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90095.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627845.1">
        <property type="nucleotide sequence ID" value="XM_627845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWF9"/>
    <dbReference type="FunCoup" id="Q5CWF9">
        <property type="interactions" value="306"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWF9"/>
    <dbReference type="GeneID" id="3375840"/>
    <dbReference type="KEGG" id="cpv:cgd6_5260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5260"/>
    <dbReference type="InParanoid" id="Q5CWF9"/>
    <dbReference type="OMA" id="CTHIADI"/>
    <dbReference type="OrthoDB" id="2110130at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03221">
        <property type="entry name" value="ABCF_EF-3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000011">
        <property type="entry name" value="Putative ABC transporter ATP-binding component"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001197">
        <property type="entry name" value="Putative ATP-binding cassette family ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032781">
        <property type="entry name" value="ABC_tran_Xtn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050611">
        <property type="entry name" value="ABCF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211:SF117">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY F MEMBER 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19211">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12848">
        <property type="entry name" value="ABC_tran_Xtn"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="197"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="4">
        <location>
            <begin position="528"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90095.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="750" mass="85017" checksum="46DACDE625732FBE" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWG1</accession>
    <name>Q5CWG1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_5240</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90093.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627843.1">
        <property type="nucleotide sequence ID" value="XM_627843.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWG1"/>
    <dbReference type="STRING" id="353152.Q5CWG1"/>
    <dbReference type="GeneID" id="3375838"/>
    <dbReference type="KEGG" id="cpv:cgd6_5240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5240"/>
    <dbReference type="InParanoid" id="Q5CWG1"/>
    <dbReference type="OMA" id="YNTNEAR"/>
    <dbReference type="OrthoDB" id="377346at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000042">
        <property type="entry name" value="Aurora kinase A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="100"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="636"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="638"/>
            <end position="658"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="6">
        <location>
            <position position="249"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7 9">
        <location>
            <position position="129"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="253"/>
            <end position="254"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="267"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="8">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90093.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="684" mass="78513" checksum="B7738202017D70E4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWI1</accession>
    <name>Q5CWI1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative peptidase of the alpha/beta-hydrolase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_4990</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627823.1">
        <property type="nucleotide sequence ID" value="XM_627823.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWI1"/>
    <dbReference type="STRING" id="353152.Q5CWI1"/>
    <dbReference type="GeneID" id="3375822"/>
    <dbReference type="KEGG" id="cpv:cgd6_4990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4990"/>
    <dbReference type="InParanoid" id="Q5CWI1"/>
    <dbReference type="OMA" id="TDIGHIC"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="3">
        <location>
            <begin position="156"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="307"/>
            <end position="381"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="383" mass="42669" checksum="FF32674BCFE34A34" modified="2007-04-03" version="1">MTDFSEKNLEYRLDSSEQQAQGQGQGQGQGQTQNENKIPSGPIIATLCCLSALGLRGKVVSSFSFFPPKLSGLVLRDRDGSEIEFKKEYIRMRFGLEKITLRSVTNIEKRLEDLLVGERKADIFCTWLESGRSKIPISCISISPVHNGDGTREKIPVFIFSHGNATDIGSMLPWFVNLSLKLNAHVLAYDYRSYGLSKGKPTERGIYADIKAVYEYARDELNFPTDRIFLLGQSIGSAPTVHLARKLRKKLKKNTGAGTTSDKSNIDCNRSGLPLGGIIIQSGIASGLNALLAPDYKKDIPCDVFPNYRNIRKVPFPILILHGTNDQVIHISNSKKLFENAKENKFHPPVTTWWIEGANHNLPGPNPKKEYYQKIGAFINSVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="27" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWI2</accession>
    <name>Q5CWI2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627822.1">
        <property type="nucleotide sequence ID" value="XM_627822.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWI2"/>
    <dbReference type="GeneID" id="3375820"/>
    <dbReference type="KEGG" id="cpv:cgd6_4980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4980"/>
    <dbReference type="InParanoid" id="Q5CWI2"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="55"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="127" mass="14946" checksum="16C3BB8A0FF8109E" modified="2007-04-03" version="1">MTNFILINHLILSHFIIYNLFVPLVYFQIFKNMLLFLSIQPIVVNMDVFTLLFIFKFDVCYLENSYMNSSNLKYYSLSLSSTKYSHNYCIAAEIAYYLHVSACNDIFPHAVIFTGNVTNVCMMLEFW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWN8</accession>
    <name>Q5CWN8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">26S proteasome regulatory subunit 7 (RPT1)-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_4350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627766.1">
        <property type="nucleotide sequence ID" value="XM_627766.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWN8"/>
    <dbReference type="FunCoup" id="Q5CWN8">
        <property type="interactions" value="479"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWN8"/>
    <dbReference type="GeneID" id="3375777"/>
    <dbReference type="KEGG" id="cpv:cgd6_4350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4350"/>
    <dbReference type="InParanoid" id="Q5CWN8"/>
    <dbReference type="OMA" id="RSKYHIE"/>
    <dbReference type="OrthoDB" id="1664597at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000005">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000075">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000027">
        <property type="entry name" value="26S protease regulatory subunit 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048723">
        <property type="entry name" value="OB_PRS7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21236">
        <property type="entry name" value="OB_PRS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6 10" id="KW-0647">Proteasome</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="9">
        <location>
            <begin position="207"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="432" mass="48217" checksum="4401A3A02C578854" modified="2007-04-03" version="1">MAVKPQIKTEKDGGKEEEDQSRPLDQVDIDIMRKYGMGPYVSKIKQVETEVKDLMSAISKLNSIRESDTGLAPPSQWDLAADRQNMQMEQPLQVARCTKIIDAGTEEAKYMINIKQMAKYVVGLGDKVAPTDIEEGMRVGVDRTKYKIQIPLPPKIDPSVAMMTVEDKPDVTYNDIGGAKEQLERLREVVEMPLLHPERFVQLGIDPPKGVLLYGPPGTGKTLTARAVANRTDACFICVIGSELVQKYVGEGARMVRELFKLARSKKACILFIDEVDAIGGARGDESAHGDHEVQRTMLEIVNQLDGFDARGNIKVLMATNRPDTLDPALLRPGRLDRKVEFGLPDLEGRTQIFRIHAKVMSMERDIRFELLSRLCPNCTGADIRSVCTEAGMFAIRARRKSISEKDLLDAINKVVKGYKKFSATAKYMVYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWS2</accession>
    <name>Q5CWS2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_3950</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus</location>
            <location evidence="1">trans-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the VPS54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90001.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627732.1">
        <property type="nucleotide sequence ID" value="XM_627732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWS2"/>
    <dbReference type="STRING" id="353152.Q5CWS2"/>
    <dbReference type="GeneID" id="3375746"/>
    <dbReference type="KEGG" id="cpv:cgd6_3950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3950"/>
    <dbReference type="InParanoid" id="Q5CWS2"/>
    <dbReference type="OMA" id="CLINWIN"/>
    <dbReference type="OrthoDB" id="10259024at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019905">
        <property type="term" value="F:syntaxin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006896">
        <property type="term" value="P:Golgi to vacuole transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039745">
        <property type="entry name" value="Vps54"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12965:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="83"/>
            <end position="102"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90001.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="961" mass="113612" checksum="8AAC1362DB373F59" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWW8</accession>
    <name>Q5CWW8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Translation initiation factor eIF2B subunit epsilon</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">eIF2B GDP-GTP exchange factor subunit epsilon</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_3420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">Component of the translation initiation factor 2B (eIF2B) complex which is a heterodecamer of two sets of five different subunits: alpha, beta, gamma, delta and epsilon. Subunits alpha, beta and delta comprise a regulatory subcomplex and subunits epsilon and gamma comprise a catalytic subcomplex. Within the complex, the hexameric regulatory complex resides at the center, with the two heterodimeric catalytic subcomplexes bound on opposite sides.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eIF-2B gamma/epsilon subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89964.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627686.1">
        <property type="nucleotide sequence ID" value="XM_627686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWW8"/>
    <dbReference type="STRING" id="353152.Q5CWW8"/>
    <dbReference type="GeneID" id="3375709"/>
    <dbReference type="KEGG" id="cpv:cgd6_3420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3420"/>
    <dbReference type="InParanoid" id="Q5CWW8"/>
    <dbReference type="OMA" id="FVICRSH"/>
    <dbReference type="OrthoDB" id="424572at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005851">
        <property type="term" value="C:eukaryotic translation initiation factor 2B complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04197">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11558">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035543">
        <property type="entry name" value="eIF-2B_epsilon_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051956">
        <property type="entry name" value="eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056764">
        <property type="entry name" value="LbH_EIF2B3/5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003307">
        <property type="entry name" value="W2_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044123">
        <property type="entry name" value="W2_eIF2B_epsilon"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45887:SF1">
        <property type="entry name" value="TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25084">
        <property type="entry name" value="LbH_EIF2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51363">
        <property type="entry name" value="W2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 11" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="W2" evidence="10">
        <location>
            <begin position="588"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="461"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="561"/>
            <end position="593"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="469"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="580"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007878"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00044144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00044345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00046432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89964.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="792" mass="88930" checksum="D391599E6290FB96" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX21</accession>
    <name>Q5CX21_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627633.1">
        <property type="nucleotide sequence ID" value="XM_627633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX21"/>
    <dbReference type="GeneID" id="3376157"/>
    <dbReference type="KEGG" id="cpv:cgd6_2850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2850"/>
    <dbReference type="InParanoid" id="Q5CX21"/>
    <dbReference type="OrthoDB" id="340998at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="126"/>
            <end position="142"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="260" mass="29411" checksum="BA3B6C5C7189BB68" modified="2007-04-03" version="1">MESEPVINQVLEEIKQSIILINESLGSEKYDISSLSNLSLSTILDICDVRIVDELPPIQTRTEDLLVIPYENSQENLSISQIHNRSSSYIIVTSPNPVSTQNEAIGGASWTYYDDCESTSEGSFLTEDEDDDGTSDSEVDMSDLDRSFKNSSGINLEKSDDLLHKGGNCNSFIEKFGRNHLNDSSNNEHFKEVFPISFRSNIPLICESFVDNQENSMSIPIDSTNILKRQLVKEINEEERNFKMVKYDSQLPIGRDQVFY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX75</accession>
    <name>Q5CX75_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-associated protein with 6 transmembrane domains possible apicomplexan conserved, duplicated adjacent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627579.1">
        <property type="nucleotide sequence ID" value="XM_627579.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX75"/>
    <dbReference type="FunCoup" id="Q5CX75">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="3376171"/>
    <dbReference type="KEGG" id="cpv:cgd6_2210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2210"/>
    <dbReference type="InParanoid" id="Q5CX75"/>
    <dbReference type="OMA" id="EAWGWIC"/>
    <dbReference type="OrthoDB" id="328372at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021691">
        <property type="entry name" value="DUF3273"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11677">
        <property type="entry name" value="DUF3273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="34"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="116"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="241"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="287" mass="31207" checksum="291F8D426E244EC4" modified="2007-04-03" version="1">MYFTYVVRPGDAPEGRGPSQPLFFENFLVNNLKLGFGSMLLGFIGLTICSIFSGFGLHITKFLSPFNEATNSTGTALFFMIFMIFGVICLNMSTILMDDDGSISQTRGFRSGCKAFGQGSLVILLGLILIVVTLYSNVGYYEGNALSGLDLNHVIKCMYNAGLAITSVGLTILGFAAFLVEVYSSDGTREILGFASILLCKVSGIFMFLTIIFPDCKTIGSLATLVTIIALTHVTLWAGIFESIALKSRIKMTQSAVRNEYYKSRNALAYFGPPVMAEGNYTQQPTM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXE8</accession>
    <name>Q5CXE8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89814.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627506.1">
        <property type="nucleotide sequence ID" value="XM_627506.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXE8"/>
    <dbReference type="GeneID" id="3376007"/>
    <dbReference type="KEGG" id="cpv:cgd6_1350"/>
    <dbReference type="InParanoid" id="Q5CXE8"/>
    <dbReference type="OMA" id="EEAYNIM"/>
    <dbReference type="OrthoDB" id="343847at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="384"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89814.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="510" mass="60226" checksum="30C254372A631E4E" modified="2005-04-12" version="1">MSEYNGIGGKLARPVIECLKSLKNYIRDYDPLENDCRYDIFQELLTFRKSWRKLSTSLEEIDNNINQDLVREFYENNICIDECRAREDFINIISKNFENNTHPAFEMYYHNNVDENEDLNYSVVSSNESFETFIKILEFDFEERQKKIAELESIKQEHLELVAESKSMDLEQEELNKYIEPFKKSLELITSYLDDSNCEENEGFCPNTLLELHKNLRPIYIYFNSFKDRINSNNDHDQVVHVNVDEYGQVVIGINRPLSKIEFDTVSTNFQDFLINIFPIKLEFSTMNTLSSREVVLLSVFMNTNKQLKCHIFSDILFDKDTGENIPLIDEETLEVLQEEISGKPYYWLQYFVNNVSVIPIKLNEMNLDPGDLFKMIECRIQNFIFFNFLLYLASIGPQLFISFILFYSEIESIDTQAIEINFDSFSFNTVNEISKHSILIKTENKDIYVEIELSGNMSYCIKFDELIYKEEFRFIENELNIDKNLVYNKEITMNFCKNLSQALLNIKPN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXE9</accession>
    <name>Q5CXE9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_1340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89815.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627505.1">
        <property type="nucleotide sequence ID" value="XM_627505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXE9"/>
    <dbReference type="STRING" id="353152.Q5CXE9"/>
    <dbReference type="GeneID" id="3376008"/>
    <dbReference type="KEGG" id="cpv:cgd6_1340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1340"/>
    <dbReference type="InParanoid" id="Q5CXE9"/>
    <dbReference type="OMA" id="EWSNIND"/>
    <dbReference type="OrthoDB" id="196858at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF56">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="206"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="257"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="309"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="340"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="377"/>
            <end position="395"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="407"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="domain" description="START" evidence="2">
        <location>
            <begin position="985"/>
            <end position="1188"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89815.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1205" mass="141452" checksum="29008B667ABD5C68" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXH3</accession>
    <name>Q5CXH3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">DnaJ(Hsp40)'DnaJ(Hsp40)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_1090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627481.1">
        <property type="nucleotide sequence ID" value="XM_627481.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXH3"/>
    <dbReference type="STRING" id="353152.Q5CXH3"/>
    <dbReference type="GeneID" id="3375865"/>
    <dbReference type="KEGG" id="cpv:cgd6_1090"/>
    <dbReference type="InParanoid" id="Q5CXH3"/>
    <dbReference type="OMA" id="CEAKFKD"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43948:SF10">
        <property type="entry name" value="MRJ, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="19"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="133"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="356"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="254"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="377" mass="42433" checksum="23887A0E732F63C5" modified="2005-04-12" version="1" fragment="single">FQFFGKISMMNAPKKSIKECCEILNLKISNLNNDGEIKKAYHKLAIKWHPDKNMGNDRQMCEAKFKDIVEAYDILTDPLKRSQAEYESRKKDIFSRGVVSGARTTKFDGSLFGGGAKFARQGTNPGLIHISHKEKQSSQGSVLGSRKSKESELRKKEDYVQLSERLINGLNSIYEVVSNAVNGSEVSVSAAASKFLDLKNTILKNKVNIKMSSSFDELSGMQHNEDTTPKPVFEKKQVLTGLNKTTSLDDDFASTSTPSDSTNSDPEKTPYLLSKNQKTPDYRMNMLNAPDYRTPNYIQQQTLCSGSDGPHMFGTSIKNNSDRFKPVSDHFREDMFEKVSVRHAHKKIIEKVKINPEGSHNTKKPSECRLTRGKFIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXI2</accession>
    <name>Q5CXI2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_1000</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627472.1">
        <property type="nucleotide sequence ID" value="XM_627472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXI2"/>
    <dbReference type="SMR" id="Q5CXI2"/>
    <dbReference type="STRING" id="353152.Q5CXI2"/>
    <dbReference type="GeneID" id="3376095"/>
    <dbReference type="KEGG" id="cpv:cgd6_1000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1000"/>
    <dbReference type="InParanoid" id="Q5CXI2"/>
    <dbReference type="OMA" id="AWEKMSD"/>
    <dbReference type="OrthoDB" id="344301at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254516" evidence="2">
        <location>
            <begin position="27"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="28"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="70"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="209"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="323" mass="36808" checksum="0069BCE9BB865924" modified="2005-04-12" version="1">MNYCKLRWSLIVLILAIVISSNYCFGKDNTDNKGNSIAKDADNGEISEKGDHIVTPDQDSNSENSENLDEGEKKEDGDKKEEGDNKEEGEKKEGDKNEDGEKKEGDKNEEGEKKEEGEKKEEGDKKEDGDNKEEGEKKEEGEKKEEGDNKEEGEKKEGDKNEDGEKKEEDKKENGEKKDGIEKFGENSDIENGIIDNKEDSVEDQENTESQKEEEKKDNGDGEQQDSIHTSIMEGLYKLDYKLKFLRRMLRKDKKMIIQIHALGYLVNTIKEQIVRDVAALNAIVKLEAENASELNKLQSVHDNHVNNRLDFIKHENIVQVNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXK4</accession>
    <name>Q5CXK4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative transcription factor with central bZIP transcription factor domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_740</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627450.1">
        <property type="nucleotide sequence ID" value="XM_627450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXK4"/>
    <dbReference type="GeneID" id="3375863"/>
    <dbReference type="KEGG" id="cpv:cgd6_740"/>
    <dbReference type="InParanoid" id="Q5CXK4"/>
    <dbReference type="OMA" id="NDEPNTR"/>
    <dbReference type="OrthoDB" id="342514at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd14686">
        <property type="entry name" value="bZIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046347">
        <property type="entry name" value="bZIP_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57959">
        <property type="entry name" value="Leucine zipper domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="32"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="224"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="43"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="449" mass="51257" checksum="36E5AB3188611A5D" modified="2005-04-12" version="1" fragment="single">IKMNNQNITPKKHKYVNENSSQMLNYENELNGKLISPPYTSDESSHSNHQSNDRLNHQHNLRHINSYRASISTNNTLSSPRSSEVIGEMIYDSGNNSVDIGKNMIGVNKENYILMNHENEKNIPSNSKSSISQNIDDLVIQRISSSKRKRMRRIPSSSRNISSKIEMEINHQKSLININNDEPNTRNYNPSSFKFTSLIDTNSEEFNSMPHSMQKKILQMIRNRQSAQKHRDKQKIERQNLIQENISLRAKIVELTNELQELRAKQFAILEQEGMLSHIKNGYRFTNYNMNTQLSNINGNIIASKRIDNINNCVNNRNSLGNEDTEINHHNIICNDNLLNEKSKTKIDNIGVKNQEIDCGFDFAPVDEYSNIGIWNSICDTGHGNTTTNGNHHLTANNSNIVRSNNFCNQLTIHPNIDVLPWIGSVGVGGVVTWNKQNNFVEDMLISSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXR8</accession>
    <name>Q5CXR8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein with coiled coil regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_5190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90475.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628662.1">
        <property type="nucleotide sequence ID" value="XM_628660.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXR8"/>
    <dbReference type="GeneID" id="3372093"/>
    <dbReference type="KEGG" id="cpv:cgd7_5190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5190"/>
    <dbReference type="InParanoid" id="Q5CXR8"/>
    <dbReference type="OMA" id="WECFNIS"/>
    <dbReference type="OrthoDB" id="337292at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90475.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="413" mass="47693" checksum="11CB11FAD4BB750E" modified="2005-04-12" version="1">MDVTGHNLSLFEENEDSIVDFITILTSVVQDSNEFLNEDQKKVTKEKIKSGILGAINSRSSLSLIDFDYNKENNFNSLINQIPDILEIREAISTGCIDLDDFEVLTRTFKSITEMCRPENISIFINKNIESTQKSQNYFATKEFIYENSINEASWHEKKSLFPSFILSMFDMITKYSHFSNIRIVMFQICREIVNTLINCNWKDDNVLTWLSRPVLSDLIISLANCTQEGDVSEPNENVQKRKQSCSSCYIREAILSSIFSKVLETFNIISKNKLLNGVIEINIIDNFSLCFSISNHIIQQYHPNCYLEQVNSNSEKGYKSWWALKSEIFNLIQMTKQSCNKDFVTLNQISLYFLNQIDSSHLTLKRISTKNQLYKNLSLNKQISNGCFFNEYLYGNIEVDLPACLQSILFNT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXU8</accession>
    <name>Q5CXU8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_4860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628632.1">
        <property type="nucleotide sequence ID" value="XM_628630.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372225"/>
    <dbReference type="KEGG" id="cpv:cgd7_4860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4860"/>
    <dbReference type="InParanoid" id="Q5CXU8"/>
    <dbReference type="OMA" id="ICHELDE"/>
    <dbReference type="OrthoDB" id="340010at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1604" mass="187016" checksum="E766F4C01E60546F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXX6</accession>
    <name>Q5CXX6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CP15/60 sporozoite 60K protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4540</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628604.1">
        <property type="nucleotide sequence ID" value="XM_628602.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXX6"/>
    <dbReference type="FunCoup" id="Q5CXX6">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="GeneID" id="3371947"/>
    <dbReference type="KEGG" id="cpv:cgd7_4540"/>
    <dbReference type="InParanoid" id="Q5CXX6"/>
    <dbReference type="OMA" id="FIFIMRD"/>
    <dbReference type="OrthoDB" id="328439at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041316">
        <property type="entry name" value="ISP1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18161">
        <property type="entry name" value="ISP1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ISP1 C-terminal" evidence="1">
        <location>
            <begin position="54"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF18161"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="156" mass="17163" checksum="BFADCDB1F71C7EB2" modified="2005-04-12" version="1" fragment="single">LLIKEKQNMGNLKSCCSFADEHSLTSTQLVVGNGSGASETASNHPQEEVNDINTFNVKLIMQDRSKLDCEVVFDSTSISLSGDGKCRNIALDEIHQLLYSKEELSRVESSAGISDSDNCVAIHLKESGNCIPLFFNNSQDKERFVATANKFKPNFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXZ1</accession>
    <name>Q5CXZ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myosin'unconventional myosin fused to an RCC1 domain (Unique)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_4350</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="7">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628589.1">
        <property type="nucleotide sequence ID" value="XM_628587.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CXZ1"/>
    <dbReference type="STRING" id="353152.Q5CXZ1"/>
    <dbReference type="GeneID" id="3372168"/>
    <dbReference type="KEGG" id="cpv:cgd7_4350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4350"/>
    <dbReference type="InParanoid" id="Q5CXZ1"/>
    <dbReference type="OMA" id="PYAITIQ"/>
    <dbReference type="OrthoDB" id="360151at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.820:FF:000001">
        <property type="entry name" value="Myosin heavy chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF270">
        <property type="entry name" value="MYOSIN-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13540">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 7" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="84"/>
            <end position="764"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="1157"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="1214"/>
            <end position="1269"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="1324"/>
            <end position="1374"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="1375"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="7">
        <location>
            <begin position="640"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="183"/>
            <end position="190"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1660" mass="189164" checksum="9CD47172E6828853" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY82</accession>
    <name>Q5CY82_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628498.1">
        <property type="nucleotide sequence ID" value="XM_628496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY82"/>
    <dbReference type="GeneID" id="3372025"/>
    <dbReference type="KEGG" id="cpv:cgd7_3340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3340"/>
    <dbReference type="InParanoid" id="Q5CY82"/>
    <dbReference type="OrthoDB" id="341491at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="181" mass="20581" checksum="9A8FFE7820603646" modified="2005-04-12" version="1">MESKYGNKIMEDRDCLSSKNTSYGLSMSNCIKPLPKDIARLALYIVCISDFSSIIQASYDIASSATVSTIFVIFSIICSSFGLLGFYSITKNNNSTMKYYVVYTILRLILESITSFGMSIIFYIYFKSAMYDENLPAWAVFLINATCLTLSRIAFSYVAFSFYQRLETQNQENFEKVTDKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYD5</accession>
    <name>Q5CYD5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">separase</fullName>
            <ecNumber evidence="2">3.4.22.49</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_2760</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>All bonds known to be hydrolyzed by this endopeptidase have arginine in P1 and an acidic residue in P4. P6 is often occupied by an acidic residue or by a hydroxy-amino-acid residue, the phosphorylation of which enhances cleavage.</text>
            <dbReference type="EC" id="3.4.22.49"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.22.49" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628445.1">
        <property type="nucleotide sequence ID" value="XM_628443.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYD5"/>
    <dbReference type="GeneID" id="3372264"/>
    <dbReference type="KEGG" id="cpv:cgd7_2760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2760"/>
    <dbReference type="InParanoid" id="Q5CYD5"/>
    <dbReference type="OMA" id="KIFIFMH"/>
    <dbReference type="OrthoDB" id="10255632at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072686">
        <property type="term" value="C:mitotic spindle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004197">
        <property type="term" value="F:cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051307">
        <property type="term" value="P:meiotic chromosome separation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005314">
        <property type="entry name" value="Peptidase_C50"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030397">
        <property type="entry name" value="SEPARIN_core_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792">
        <property type="entry name" value="EXTRA SPINDLE POLES 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12792:SF0">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03568">
        <property type="entry name" value="Separin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51700">
        <property type="entry name" value="SEPARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0159">Chromosome partition</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase C50" evidence="5">
        <location>
            <begin position="2256"/>
            <end position="2367"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000451"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022829"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51700"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2442" mass="286893" checksum="D8D8D2AEB7357AC8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYF1</accession>
    <name>Q5CYF1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">AMSJ/WSAK like polysaccharide polymerase (Glycosyltransferase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90623.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628429.1">
        <property type="nucleotide sequence ID" value="XM_628427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYF1"/>
    <dbReference type="GeneID" id="3371971"/>
    <dbReference type="KEGG" id="cpv:cgd7_2580"/>
    <dbReference type="InParanoid" id="Q5CYF1"/>
    <dbReference type="OMA" id="GIADHEN"/>
    <dbReference type="OrthoDB" id="6134158at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007345">
        <property type="entry name" value="Polysacch_pyruvyl_Trfase"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04230">
        <property type="entry name" value="PS_pyruv_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Polysaccharide pyruvyl transferase" evidence="1">
        <location>
            <begin position="97"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90623.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="453" mass="52941" checksum="1B2A08F91183D6EF" modified="2005-04-12" version="1" fragment="single">GEVKHRNSSFIGLEKNNQKFNDEIKKIFEIDNWFNNYPELLLNLSEKSPKLLSESMRKYTRISDNFFVQGEIMMSILKYTIGNVENGIVFGIADHENKGDAGINWSQYLVFKRLNIKIIYYCTSNYSHKPCDIKRALNIANTLPRKPTIFLTGGGNLGDVWPKYEYERKKILEEFREFNTVIFPQSISLKSKDTIIDFDYLKMHKNLTIFVRDIYSFGFLHSILFNNQSTTNTKLLLTPDIVTSIVTTKEKKSPNTAAHLVFNETYDILWINRNDRETSKRQWNKNYNANLNIKVDDWIKFMPTTYSKGISFGNKYILKSGEEIAPPQFVSNNVFNSTYEYDEPNFDVFSIGISLQRFCAGLNFILQGKVIITNRLHGHIFSSLLNKNQILLDTKFKKILNYYKTWSFSIDEDYIKLANSEKDALESAEEMSRRFPSDNRTELFYIYCGKLYL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYG7</accession>
    <name>Q5CYG7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Chaperonin 10 Kd subunit, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_2400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the GroES chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90622.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628413.1">
        <property type="nucleotide sequence ID" value="XM_628411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYG7"/>
    <dbReference type="FunCoup" id="Q5CYG7">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYG7"/>
    <dbReference type="GeneID" id="3371970"/>
    <dbReference type="KEGG" id="cpv:cgd7_2400"/>
    <dbReference type="InParanoid" id="Q5CYG7"/>
    <dbReference type="OMA" id="KERPMQG"/>
    <dbReference type="OrthoDB" id="184876at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044183">
        <property type="term" value="F:protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00320">
        <property type="entry name" value="cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.33.40">
        <property type="entry name" value="GroES chaperonin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020818">
        <property type="entry name" value="Chaperonin_GroES"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037124">
        <property type="entry name" value="Chaperonin_GroES_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018369">
        <property type="entry name" value="Chaprnonin_Cpn10_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011032">
        <property type="entry name" value="GroES-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10772:SF0">
        <property type="entry name" value="10 KDA HEAT SHOCK PROTEIN, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00166">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00297">
        <property type="entry name" value="CHAPERONIN10"/>
    </dbReference>
    <dbReference type="SMART" id="SM00883">
        <property type="entry name" value="Cpn10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50129">
        <property type="entry name" value="GroES-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00681">
        <property type="entry name" value="CHAPERONINS_CPN10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90622.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="121" mass="13612" checksum="0D3AF28F35CDEE8C" modified="2005-04-12" version="1" fragment="single">QVNKLLRTFRPIFDRVLVQRIHPKAVTKSGILLPESINKGGKGFFMAKVLSTGTGKINQFTGEYNKCLLKPGDTVIVPEYGGIHIQQFYEEVNHGTSLDLMVYKEEDILGIFENDSKNNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYN4</accession>
    <name>Q5CYN4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">STOP repeat protein involved in microtubule stabilization (Possible variant metal binding site at N-terminus)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_1660</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90604.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628346.1">
        <property type="nucleotide sequence ID" value="XM_628344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYN4"/>
    <dbReference type="STRING" id="353152.Q5CYN4"/>
    <dbReference type="GeneID" id="3371789"/>
    <dbReference type="KEGG" id="cpv:cgd7_1660"/>
    <dbReference type="InParanoid" id="Q5CYN4"/>
    <dbReference type="OMA" id="SCYRSEY"/>
    <dbReference type="OrthoDB" id="365640at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90604.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="244" mass="28512" checksum="C2DD1A1D409B6A43" modified="2005-04-12" version="1" fragment="single">KINFNYLINFYLQKSEHLLSRGRKVGRCPDEHCRSKSPSGQPGKSVEELCTCGKHICPAPLHDSISFQAESSYNTEFKQWELPTFPKPVPEELPKSIPFDSDSSYHMDYRKWDLPKKIVRPPEQFSESPENRDFMTSYQSNFKQWELPKFKKPQPPPEVVSSPYGNINSVYRENYQQWDLPKKIVNPSEIYSPSKEDRNFETVYRNSYQGVQPPVCPVSLLPPIPHPPPGRHTMFWDSVSKNWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYQ4</accession>
    <name>Q5CYQ4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Coiled-coil domain-containing protein 86</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd7_1420</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Required for proper chromosome segregation during mitosis and error-free mitotic progression.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
            <location evidence="2">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90198.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628326.1">
        <property type="nucleotide sequence ID" value="XM_628324.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYQ4"/>
    <dbReference type="GeneID" id="3372244"/>
    <dbReference type="KEGG" id="cpv:cgd7_1420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1420"/>
    <dbReference type="InParanoid" id="Q5CYQ4"/>
    <dbReference type="OMA" id="NMVVQNI"/>
    <dbReference type="OrthoDB" id="343392at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026570">
        <property type="entry name" value="CCDC86"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13557">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13557:SF1">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 86"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6" id="KW-0164">Citrullination</keyword>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="12"/>
            <end position="22"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022934"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00093307"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK90198.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="125" mass="14909" checksum="752B936304A7D1D5" modified="2005-04-12" version="1">MSDSSILLYENKSQRESGRPWKDTPNLKSKLQKRVTGKKKTYEERIREKKEIQRIRGIELAEKEERAKARKEAKERKRLKQQAKMNREILSSGVQVITRTDKIKNWNKKARKMLRKVSLESLNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYV4</accession>
    <name>Q5CYV4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Eukaryotic translation initiation factor 2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat EIF2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628276.1">
        <property type="nucleotide sequence ID" value="XM_628274.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYV4"/>
    <dbReference type="STRING" id="353152.Q5CYV4"/>
    <dbReference type="GeneID" id="3371987"/>
    <dbReference type="KEGG" id="cpv:cgd7_880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_880"/>
    <dbReference type="InParanoid" id="Q5CYV4"/>
    <dbReference type="OMA" id="IIHDISW"/>
    <dbReference type="OrthoDB" id="2194683at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011387">
        <property type="entry name" value="TIF2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013979">
        <property type="entry name" value="TIF_beta_prop-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13227:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08662">
        <property type="entry name" value="eIF2A"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82171">
        <property type="entry name" value="DPP6 N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="6" id="KW-0810">Translation regulation</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="9">
        <location>
            <begin position="254"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Translation initiation factor beta propellor-like" evidence="9">
        <location>
            <begin position="342"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="306"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="564"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="574"/>
            <end position="586"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022845"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="586" mass="65403" checksum="E18E843EB04DBAA7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ17</accession>
    <name>Q5CZ17_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_190</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628213.1">
        <property type="nucleotide sequence ID" value="XM_628211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ17"/>
    <dbReference type="GeneID" id="3371763"/>
    <dbReference type="KEGG" id="cpv:cgd7_190"/>
    <dbReference type="InParanoid" id="Q5CZ17"/>
    <dbReference type="OMA" id="EISIECM"/>
    <dbReference type="OrthoDB" id="4977at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028133">
        <property type="entry name" value="Dynamitin"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04912">
        <property type="entry name" value="Dynamitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="122" mass="14247" checksum="B4EB46658470BC7E" modified="2005-04-12" version="1" fragment="single">FDDQSKKHKFFQYINSVGKSTSGEGVEDKEQEIEISIECMKDNSESILDLKNLLELERRVYEVESRIGVDRLSEMPYSDIQSAIHNISQRLSLLDTNRLEGIFRRVQVGFDLNNQRSERIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ22</accession>
    <name>Q5CZ22_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">40S ribosomal protein S14</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_130</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Plastid</location>
            <location evidence="1">Chloroplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 5">Belongs to the universal ribosomal protein uS11 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90664.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628208.1">
        <property type="nucleotide sequence ID" value="XM_628206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ22"/>
    <dbReference type="FunCoup" id="Q5CZ22">
        <property type="interactions" value="275"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CZ22"/>
    <dbReference type="GeneID" id="3371761"/>
    <dbReference type="KEGG" id="cpv:cgd7_130"/>
    <dbReference type="InParanoid" id="Q5CZ22"/>
    <dbReference type="OMA" id="IYASHND"/>
    <dbReference type="OrthoDB" id="1677536at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009507">
        <property type="term" value="C:chloroplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.80:FF:000002">
        <property type="entry name" value="40S ribosomal protein S14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.80">
        <property type="entry name" value="Ribosomal protein S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01310">
        <property type="entry name" value="Ribosomal_uS11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001971">
        <property type="entry name" value="Ribosomal_uS11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018102">
        <property type="entry name" value="Ribosomal_uS11_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036967">
        <property type="entry name" value="Ribosomal_uS11_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007176">
        <property type="entry name" value="PRK09607.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11759">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S14/30S RIBOSOMAL PROTEIN S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00411">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002131">
        <property type="entry name" value="Ribosomal_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00054">
        <property type="entry name" value="RIBOSOMAL_S11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="112"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="122"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004229"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90664.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="131" mass="14174" checksum="ECD67B9F1A12042A" modified="2005-04-12" version="1" fragment="single">VREGQTNFAVAHIFASFNDTFIHVTDLSGRETIVRVTGGMKVKADRDENSPYAAMMAAVDVAQKCKEFGIHALHIKLRAVGGVKSKTMGPGAQSALRALARAGMKIGRIEDVTPIPTDSTRRKGGRRGRRL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPT7</accession>
    <name>A3FPT7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Anaphase promoting complex subunit 10, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_1850</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the APC10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51510.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388316.1">
        <property type="nucleotide sequence ID" value="XM_001388279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPT7"/>
    <dbReference type="STRING" id="353152.A3FPT7"/>
    <dbReference type="GeneID" id="3375941"/>
    <dbReference type="KEGG" id="cpv:cgd6_1850"/>
    <dbReference type="InParanoid" id="A3FPT7"/>
    <dbReference type="OMA" id="RDQPAQT"/>
    <dbReference type="OrthoDB" id="24948at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005680">
        <property type="term" value="C:anaphase-promoting complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031145">
        <property type="term" value="P:anaphase-promoting complex-dependent catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070979">
        <property type="term" value="P:protein K11-linked ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08366">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016901">
        <property type="entry name" value="APC10/Doc1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004939">
        <property type="entry name" value="APC_su10/DOC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12936:SF0">
        <property type="entry name" value="ANAPHASE-PROMOTING COMPLEX SUBUNIT 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03256">
        <property type="entry name" value="ANAPC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF028841">
        <property type="entry name" value="APC10_sub"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01337">
        <property type="entry name" value="APC10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51284">
        <property type="entry name" value="DOC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="2" id="KW-0132">Cell division</keyword>
    <keyword evidence="3" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="DOC" evidence="6">
        <location>
            <begin position="1"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006762"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51510.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="132" mass="14914" checksum="981695EEE2B1043A" modified="2007-04-03" version="1">MPSLPNQTCDDFMSSLIEIGDLASWSLSSAKPGNGIQQLRDNNSSTFWQSDGQSPHTITLRFPKKTKVSVIDLYLAYKIDESYTPQIISIRSGNQESDLEELKEMQLTEPDGWVRIPLSPREIADNFFKDAM</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPU1</accession>
    <name>A3FPU1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">BT1 family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_2020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388320.1">
        <property type="nucleotide sequence ID" value="XM_001388283.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPU1"/>
    <dbReference type="STRING" id="353152.A3FPU1"/>
    <dbReference type="GeneID" id="3375945"/>
    <dbReference type="KEGG" id="cpv:cgd6_2020"/>
    <dbReference type="InParanoid" id="A3FPU1"/>
    <dbReference type="OrthoDB" id="754047at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039309">
        <property type="entry name" value="BT1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31585:SF0">
        <property type="entry name" value="FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03092">
        <property type="entry name" value="BT1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="96"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="118"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="143" mass="15804" checksum="9CE73530C622467A" modified="2007-04-03" version="1">MDGTLHQNEIISLLDEKRTISSTIKFSSLLGSITITKLVIFLVGFSDGLTHLATLAIYYLLKDDLRLSPPEVSVIYAIPAIPWFLKPLFGMRRKPYLIFFSILQVIGFLLLATNADTVFKAAVCLLLISLSAAFCSSIAEVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPV8</accession>
    <name>A3FPV8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388337.1">
        <property type="nucleotide sequence ID" value="XM_001388300.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPV8"/>
    <dbReference type="STRING" id="353152.A3FPV8"/>
    <dbReference type="GeneID" id="3375962"/>
    <dbReference type="KEGG" id="cpv:cgd6_3460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3460"/>
    <dbReference type="InParanoid" id="A3FPV8"/>
    <dbReference type="OMA" id="TCECTDE"/>
    <dbReference type="OrthoDB" id="344274at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="92"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="353"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="557"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="699"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="23"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="368"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="615"/>
            <end position="637"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="699"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="764"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="780" mass="81671" checksum="03F84D1937CDA7D6" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPW4</accession>
    <name>A3FPW4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Elongation factor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_3960</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388343.1">
        <property type="nucleotide sequence ID" value="XM_001388306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPW4"/>
    <dbReference type="STRING" id="353152.A3FPW4"/>
    <dbReference type="GeneID" id="3375968"/>
    <dbReference type="KEGG" id="cpv:cgd6_3960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3960"/>
    <dbReference type="InParanoid" id="A3FPW4"/>
    <dbReference type="OMA" id="IYICMGG"/>
    <dbReference type="OrthoDB" id="364892at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042256">
        <property type="term" value="P:cytosolic ribosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04096">
        <property type="entry name" value="eEF2_snRNP_like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01885">
        <property type="entry name" value="EF2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.870:FF:000002">
        <property type="entry name" value="Translation elongation factor 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.870">
        <property type="entry name" value="Elongation Factor G (Translational Gtpase), domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.10">
        <property type="entry name" value="Translation factors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1430.10">
        <property type="entry name" value="Yeast translation eEF2 (G' domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041095">
        <property type="entry name" value="EFG_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035647">
        <property type="entry name" value="EFG_III/V"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000640">
        <property type="entry name" value="EFG_V-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000795">
        <property type="entry name" value="T_Tr_GTP-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009000">
        <property type="entry name" value="Transl_B-barrel_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908:SF3">
        <property type="entry name" value="ELONGATION FACTOR-LIKE GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42908">
        <property type="entry name" value="TRANSLATION ELONGATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00679">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14492">
        <property type="entry name" value="EFG_III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00009">
        <property type="entry name" value="GTP_EFTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00315">
        <property type="entry name" value="ELONGATNFCT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00838">
        <property type="entry name" value="EFG_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54980">
        <property type="entry name" value="EF-G C-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50447">
        <property type="entry name" value="Translation proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51722">
        <property type="entry name" value="G_TR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tr-type G" evidence="4">
        <location>
            <begin position="3"/>
            <end position="243"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="640"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1028"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="648"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1052"/>
            <end position="1063"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1100" mass="125227" checksum="13995ADF67BEF8E8" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPW7</accession>
    <name>A3FPW7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Formin-related protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_4150</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388346.1">
        <property type="nucleotide sequence ID" value="XM_001388309.1"/>
    </dbReference>
    <dbReference type="SMR" id="A3FPW7"/>
    <dbReference type="FunCoup" id="A3FPW7">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPW7"/>
    <dbReference type="GeneID" id="3375971"/>
    <dbReference type="KEGG" id="cpv:cgd6_4150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4150"/>
    <dbReference type="InParanoid" id="A3FPW7"/>
    <dbReference type="OMA" id="RRFFWDP"/>
    <dbReference type="OrthoDB" id="1668162at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051425">
        <property type="entry name" value="Formin_Homology"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725:SF1">
        <property type="entry name" value="DISHEVELLED ASSOCIATED ACTIVATOR OF MORPHOGENESIS, ISOFORM D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45725">
        <property type="entry name" value="FORMIN HOMOLOGY 2 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00498">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="2">
        <location>
            <begin position="1145"/>
            <end position="1545"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="414"/>
            <end position="433"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1052"/>
            <end position="1160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1538"/>
            <end position="1574"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="52"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="84"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="104"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="119"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="144"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="422"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1078"/>
            <end position="1099"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="1100"/>
            <end position="1128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1562"/>
            <end position="1574"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1638" mass="179228" checksum="AAFB27B18FC357C6" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPY4</accession>
    <name>A3FPY4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">cgd8_1820</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">P-body</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51465.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388425.1">
        <property type="nucleotide sequence ID" value="XM_001388388.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPY4"/>
    <dbReference type="SMR" id="A3FPY4"/>
    <dbReference type="FunCoup" id="A3FPY4">
        <property type="interactions" value="474"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPY4"/>
    <dbReference type="GeneID" id="3374644"/>
    <dbReference type="KEGG" id="cpv:cgd8_1820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1820"/>
    <dbReference type="InParanoid" id="A3FPY4"/>
    <dbReference type="OMA" id="TYEDRHT"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd17940">
        <property type="entry name" value="DEADc_DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000114">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000364">
        <property type="entry name" value="ATP-dependent RNA helicase DDX6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47960">
        <property type="entry name" value="DEAD-BOX ATP-DEPENDENT RNA HELICASE 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 12 17" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="16">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="14">
        <location>
            <begin position="64"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="15">
        <location>
            <begin position="244"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="33"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="18"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038316"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAZ51465.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="406" mass="46038" checksum="80F98B275AF45F50" modified="2007-04-03" version="1">MKTERLSNDMKGLNIPPKDPRFKTDDVTKTKGSDFEDYFLKRELLMGIYEKGFERPSPIQEESIPVALAGKDILARAKNGTGKTAAFVIPLLEKINTKKNIIQGLILVPTRELALQTSSIVKQLGKHINVQCMVSTGGTSLRDDILRLNNPVHVLVGTPGRILDLSNKKVCNLSGCFMFIMDEADKLLSPEFQPIIEELIEFLPKERQILLYSATFPVTVKGFKDKYLANAHEINLMDELTLKGVTQYYAFVEEKQKLHCLNTLFSKLQINQAIIFCNSVTRVELLAKKITELGSSCFYIHARMLQSHRNRVFHDFRNGACRCLVSSDLITRGIDIQSVNVVINFDFPKYSETYLHRIGRSGRFGHLGLAINLITYEDRYNLYRIEKELATEISPIPAQIDSALYT</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ15</accession>
    <name>A3FQ15_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Flavoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388095.1">
        <property type="nucleotide sequence ID" value="XM_001388058.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ15"/>
    <dbReference type="FunCoup" id="A3FQ15">
        <property type="interactions" value="144"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ15"/>
    <dbReference type="GeneID" id="3373945"/>
    <dbReference type="KEGG" id="cpv:cgd3_870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_870"/>
    <dbReference type="InParanoid" id="A3FQ15"/>
    <dbReference type="OMA" id="KGLACGD"/>
    <dbReference type="OrthoDB" id="1532798at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071513">
        <property type="term" value="C:phosphopantothenoylcysteine decarboxylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010181">
        <property type="term" value="F:FMN binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004633">
        <property type="term" value="F:phosphopantothenoylcysteine decarboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015937">
        <property type="term" value="P:coenzyme A biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1950">
        <property type="entry name" value="Flavin prenyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036551">
        <property type="entry name" value="Flavin_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003382">
        <property type="entry name" value="Flavoprotein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359">
        <property type="entry name" value="HOMO-OLIGOMERIC FLAVIN CONTAINING CYS DECARBOXYLASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14359:SF6">
        <property type="entry name" value="PHOSPHOPANTOTHENOYLCYSTEINE DECARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02441">
        <property type="entry name" value="Flavoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52507">
        <property type="entry name" value="Homo-oligomeric flavin-containing Cys decarboxylases, HFCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0173">Coenzyme A biosynthesis</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Flavoprotein" evidence="3">
        <location>
            <begin position="5"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022993"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02441"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="188" mass="21047" checksum="BD60827C2BB9E8BF" modified="2007-04-03" version="1" fragment="single">MKKRNVLIGVTGSVAAIKIHEFIKKLKEKVISNNIEIEIKVVATDSAKNFLNGLALDLLVDCQDEFGNWKSMGDDIPHISLRQWADLYIILPLSANTLAKLSNGLCDNVLTNIARAWDFKKPIIVCPAMNSFMWEHPITLTQINILISFGYKVVFPIEKKLACGEYGMGGMQEIEKIVEQILLELNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQF5</accession>
    <name>A3FQF5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_2940</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388177.1">
        <property type="nucleotide sequence ID" value="XM_001388140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQF5"/>
    <dbReference type="GeneID" id="3371392"/>
    <dbReference type="KEGG" id="cpv:cgd1_2940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2940"/>
    <dbReference type="InParanoid" id="A3FQF5"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAZ51354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="258" mass="30115" checksum="51248888939F3ECC" modified="2007-04-03" version="1">MILLYATQHGEGNVKVKMRMGNKIWEFTLLCNLNDGSFYVGNSESFDYTNWDWITEFSVSMKMSLGLEYLQEKYFSMELYAKSCLKKIQSYLVLSKFWNSHIFLNFETNMKMDASDLIKGNINLSFFDIFEDNFIRYSSNKGSKYKIDSVFGFLREFHVKKENQVDDIEYQNVDKENQSNLNISNTSQTTSLKTGYLYVYRFSNGMPIICKDTEYCDIVTSVKSFIRKKGNIFGMKLAKKDEILENNHEKLSVFSGVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQF6</accession>
    <name>A3FQF6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FAM50A/XAP5 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_2950</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388178.1">
        <property type="nucleotide sequence ID" value="XM_001388141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQF6"/>
    <dbReference type="STRING" id="353152.A3FQF6"/>
    <dbReference type="GeneID" id="3371391"/>
    <dbReference type="KEGG" id="cpv:cgd1_2950"/>
    <dbReference type="InParanoid" id="A3FQF6"/>
    <dbReference type="OMA" id="MEFQKDQ"/>
    <dbReference type="OrthoDB" id="1562195at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048337">
        <property type="entry name" value="FAM50A/XAP5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007005">
        <property type="entry name" value="XAP5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722:SF0">
        <property type="entry name" value="PROTEIN FAM50A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12722">
        <property type="entry name" value="XAP-5 PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04921">
        <property type="entry name" value="XAP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAM50A/XAP5 C-terminal" evidence="2">
        <location>
            <begin position="168"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04921"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="216" mass="25363" checksum="C417E414CD0A0197" modified="2007-04-03" version="1">MKSIEEMFYSKSTEDEEQFRSRTMGLVSMETYKRHISDIRRGIKPENVSKKTKIIPESKPKKMKYNTLSFEFNQGDDIPDQIPDKEDRSETISKEITLTAIKDSLSGENKSTESLEKHSEFDFSTIGKDTSIDTSFLPDKKRELEEAKAREKLKQEEFEKEEKLKQEIIEVVFSYWDGSGHRRSVHVPRNTTIGEFLEKCRIKLKSEFKEFSRLSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQR9</accession>
    <name>A3FQR9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Latent transforming growth factor beta binding protein like (3F865)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAZ51202.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388089.1">
        <property type="nucleotide sequence ID" value="XM_001388052.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQR9"/>
    <dbReference type="STRING" id="353152.A3FQR9"/>
    <dbReference type="GeneID" id="3372328"/>
    <dbReference type="KEGG" id="cpv:cgd3_190"/>
    <dbReference type="InParanoid" id="A3FQR9"/>
    <dbReference type="OMA" id="WIRDEYR"/>
    <dbReference type="OrthoDB" id="339125at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00054">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.25.10">
        <property type="entry name" value="Laminin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026823">
        <property type="entry name" value="cEGF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018097">
        <property type="entry name" value="EGF_Ca-bd_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039:SF52">
        <property type="entry name" value="EGF-LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24039">
        <property type="entry name" value="FIBRILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12662">
        <property type="entry name" value="cEGF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01187">
        <property type="entry name" value="EGF_CA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="1" id="KW-0245">EGF-like domain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Complement Clr-like EGF" evidence="6">
        <location>
            <begin position="570"/>
            <end position="590"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="10"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="62"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="138"/>
            <end position="326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="62"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="97"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022536"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12662"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51202.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="620" mass="67719" checksum="B33512E6253827E7" modified="2007-04-03" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPH9</accession>
    <name>Q5CPH9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87354.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625370.1">
        <property type="nucleotide sequence ID" value="XM_625370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPH9"/>
    <dbReference type="GeneID" id="3375649"/>
    <dbReference type="KEGG" id="cpv:cgd6_340"/>
    <dbReference type="InParanoid" id="Q5CPH9"/>
    <dbReference type="OrthoDB" id="10248398at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="105"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87354.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="110" mass="12391" checksum="3F3AB3C8D38950B1" modified="2005-04-12" version="1">MNTNFCAGNCNSNIISIIVPGRNPETVINEGNGIVSTIVQNPQTVSNVVVAANGEVFTGDSGGKYFLFYFFVIKNYIYKIYLFIYSWSIFQFLSISILGISWCTYKFKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPK5</accession>
    <name>Q5CPK5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Serine repeat antigen</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_40</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625344.1">
        <property type="nucleotide sequence ID" value="XM_625344.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPK5"/>
    <dbReference type="STRING" id="353152.Q5CPK5"/>
    <dbReference type="GeneID" id="3375664"/>
    <dbReference type="KEGG" id="cpv:cgd6_40"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_40"/>
    <dbReference type="InParanoid" id="Q5CPK5"/>
    <dbReference type="OrthoDB" id="344248at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253712" description="Serine repeat antigen" evidence="2">
        <location>
            <begin position="26"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="74"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="98"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="117"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="133"/>
            <end position="180"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="192" mass="19686" checksum="CB363BF9E9B40F77" modified="2007-04-03" version="1">MKFLSNLSIISILAVIAVFYSFTSTESDLASSSYYELSFVKVKCGGGFCKRLRRALCCCSGGEEEEQPEMVIGNPTDFQHLHSGGLQMRDSDGRLTSRIPSLGTSGPDFSNEGYQSGDEDNNEGNDDTSSVTSSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSGSSSSGSSSSGSSSSSSPPVNGNEYDTKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPP7</accession>
    <name>Q5CPP7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cysteine desulfurase/selenocysteine lyase-like PLP dependent transferase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_30</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87393.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625374.1">
        <property type="nucleotide sequence ID" value="XM_625374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPP7"/>
    <dbReference type="STRING" id="353152.Q5CPP7"/>
    <dbReference type="GeneID" id="3372343"/>
    <dbReference type="KEGG" id="cpv:cgd2_30"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_30"/>
    <dbReference type="InParanoid" id="Q5CPP7"/>
    <dbReference type="OMA" id="WEWDRIF"/>
    <dbReference type="OrthoDB" id="10264306at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237:SF80">
        <property type="entry name" value="MOLYBDENUM COFACTOR SULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14237">
        <property type="entry name" value="MOLYBDOPTERIN COFACTOR SULFURASE MOSC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0456">Lyase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253720" evidence="1">
        <location>
            <begin position="24"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="Aminotransferase class V" evidence="2">
        <location>
            <begin position="73"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87393.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="503" mass="56627" checksum="C1BA98B1662AE7B3" modified="2005-04-12" version="1">MRILLILLLFLSIKTNLIHFCLAGNFLVVNNAANGSEHEILHSNFLKEFGNDYNKQVEEISRVELNRFKGQTYLDYTGSGLYQKSQLEEIYTDFINNAYGNAHSRNPSAELTNKKLSEARELLFNFFNISKDTHTIIFTGGATGGLKLIGEDFPWTKQSKFYYTRVNHNSVLGIREYAVSKGAEFRALSFNDIEKILAQREKDYKEKKDGKSENLCLFAFPGKDNFSGEKYPLKWIKQVQKYGLSDDCDWKVILDAAAMVPTEKLDISENSADFVVISFYKMFGYPTGLGALISKTDQVNKFNKLYFGGGTVVMASCDSRWCKMRENPSEKFEDGTVSFLSIVSLKYGLNKLQSIGMDKINKHVSSLTLFTFNLLSQLRHFSGGNVVHFYGRFASPPTGGIINFNLLKPDGTFVHYFKVEQMASDSNIHLRTGCFCNPGACQDYLGLTLEEIQITSEVKNSCSDPAAGLAGKPLGSIRISFGYLSTFKDVLAIYDFIKTNFVH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPR8</accession>
    <name>Q5CPR8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ring finger domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_4310</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87417.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625446.1">
        <property type="nucleotide sequence ID" value="XM_625446.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPR8"/>
    <dbReference type="STRING" id="353152.Q5CPR8"/>
    <dbReference type="GeneID" id="3372391"/>
    <dbReference type="KEGG" id="cpv:cgd4_4310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4310"/>
    <dbReference type="InParanoid" id="Q5CPR8"/>
    <dbReference type="OMA" id="IENFHEY"/>
    <dbReference type="OrthoDB" id="21204at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16454">
        <property type="entry name" value="RING-H2_PA-TM-RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="411"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87417.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="461" mass="54268" checksum="EA27A44DC21C04A0" modified="2005-04-12" version="1">MESNLYVSRQRGDETNHILVREYQTCLSGYPDTRQHGSFENLSRPYTPLRDITGSIFGGLVRESRVRSVNESNDFNRIRNSMVERLNRESIRGPESRFFGFDSNNRNTSYYNSHENDIRAFNRSMSMSSPNLDIGFASLSRNSSNEAIENNSSFLNRSRSFADRIMEQFDIVEREHNQLAERIHRSQSIYEQIQRNGAEIDQLFDNLSYRMQRRHTQRENSTGNNFQSRNTRYGGSVIDCSRNGHINHRFSNRPRFVSMQDVHNHFRDNLLATEEHEEEEDYDDQDNDVIEIIQVDDDEISDIISRRNADIRNRSLIITQEEIIMEESNDPEDSEDEHEQNHGQEYDQYHEDEEMHNDGNITRVLNRLRDRISQNQEEDVSGVPINIQNALPVSKFDLSRSQNLDDDKKMCLICLDEFKDQQEILWLPCTHCFCRNCITSWFERGTVCPICKDDLLAHFNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPR9</accession>
    <name>Q5CPR9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Beta adaptin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_4300</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625445.1">
        <property type="nucleotide sequence ID" value="XM_625445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPR9"/>
    <dbReference type="FunCoup" id="Q5CPR9">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPR9"/>
    <dbReference type="GeneID" id="3372433"/>
    <dbReference type="KEGG" id="cpv:cgd4_4300"/>
    <dbReference type="InParanoid" id="Q5CPR9"/>
    <dbReference type="OMA" id="NPPEVQW"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030276">
        <property type="term" value="F:clathrin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016342">
        <property type="entry name" value="AP_complex_bsu_1_2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002291">
        <property type="entry name" value="AP_complex_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="7">
        <location>
            <begin position="29"/>
            <end position="584"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="740"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="770" mass="87314" checksum="5AB7970D74A6125A" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPS4</accession>
    <name>Q5CPS4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_4250</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87422.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625440.1">
        <property type="nucleotide sequence ID" value="XM_625440.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPS4"/>
    <dbReference type="GeneID" id="3372396"/>
    <dbReference type="KEGG" id="cpv:cgd4_4250"/>
    <dbReference type="InParanoid" id="Q5CPS4"/>
    <dbReference type="OrthoDB" id="338667at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87422.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="185" mass="21505" checksum="3872F9B98FD943CC" modified="2005-04-12" version="1">MLYLKDEKLDERTQIWGFAALRFLIRSSLNACNEFLKLGVFELITKKLGKNQDIFLIENILAIYVSILFTSQDFKLNNPDIIREILEIIDINVNNHQIVQQGLIVLIKSCQRTEVYSHIIAAYGAKRIIQSILQVYKKDPEFSQIIKLSKYLMRCLCSFCSKTTLIKLVNNQLVFSHQFDPGRFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ03</accession>
    <name>Q5CQ03_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625476.1">
        <property type="nucleotide sequence ID" value="XM_625476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ03"/>
    <dbReference type="GeneID" id="3372494"/>
    <dbReference type="KEGG" id="cpv:cgd8_120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_120"/>
    <dbReference type="InParanoid" id="Q5CQ03"/>
    <dbReference type="OrthoDB" id="336780at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="38"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="41"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="58"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="73"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="122" mass="13586" checksum="E67FB0676074A979" modified="2005-04-12" version="1">MDFELVVQPLDNPEQESMTLKLQGKNMETVGTCLFFADTEPTNKDSSDGKPKTGINENHLHSDLNDDKDVEMSDQNRANSSSEIKPHSETQNRESNIVNDGSKSKLVCIGKCKKVVQAFIED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ46</accession>
    <name>Q5CQ46_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">PP2C like protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_4170</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625580.1">
        <property type="nucleotide sequence ID" value="XM_625580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ46"/>
    <dbReference type="FunCoup" id="Q5CQ46">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ46"/>
    <dbReference type="GeneID" id="3372532"/>
    <dbReference type="KEGG" id="cpv:cgd5_4170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4170"/>
    <dbReference type="InParanoid" id="Q5CQ46"/>
    <dbReference type="OMA" id="HSYIKTC"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="6">
        <location>
            <begin position="166"/>
            <end position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="445" mass="49693" checksum="3E189293637B4B98" modified="2005-04-12" version="1">MGGCFSKKSINKENLVFSQEKNNCVSNLPNTVTNFSMNPYTNMEGGNKGFSNYSAVNYDRRRLSVSQSDPVNDSDINDIPRGRAVFNASYKDSPQFKPSEFMTPSGIHNGILNDFNNQKADSFELGNSRRRLSVTGMLSQRAQETFESKAEEVIGNDSGNSELQRGIGYVCRKGLKPESPNQDDFFILKTENWGLFGVFDGHGPFGHDVSNFIQKDMPALILKDKQWKTHPQDVLHYAFIKANQRLQEHVLETNQFDCSLSGTTATVILHLPLENRIIAAHVGDSRSVLARWSRSGRVLEAVDLTNDHKPNSESEKRRIIAAGGQVKRIEGDIPYRVFIKGKMYPGLAMSRAIGDTLGYQAGIIPEPDINTFQIQPEKDAFILICSDGVWEFISSQEAVDIVAEGGSSDAQLSAEKLAREAWRRWIQEEGNVVDDITVQVIYLQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ99</accession>
    <name>Q5CQ99_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Phospholipase/carboxylesterase/thioesterase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_1530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87602.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625749.1">
        <property type="nucleotide sequence ID" value="XM_625749.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ99"/>
    <dbReference type="SMR" id="Q5CQ99"/>
    <dbReference type="STRING" id="353152.Q5CQ99"/>
    <dbReference type="ESTHER" id="crypv-q5cq99">
        <property type="family name" value="ABHD17-depalmitoylase"/>
    </dbReference>
    <dbReference type="GeneID" id="3372703"/>
    <dbReference type="KEGG" id="cpv:cgd4_1530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1530"/>
    <dbReference type="InParanoid" id="Q5CQ99"/>
    <dbReference type="OMA" id="PRCLEIN"/>
    <dbReference type="OrthoDB" id="446723at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003140">
        <property type="entry name" value="PLipase/COase/thioEstase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277">
        <property type="entry name" value="ALPHA/BETA HYDROLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12277:SF81">
        <property type="entry name" value="PROTEIN ABHD13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02230">
        <property type="entry name" value="Abhydrolase_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phospholipase/carboxylesterase/thioesterase" evidence="2">
        <location>
            <begin position="149"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="386"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="431"/>
            <end position="450"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="387"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF02230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87602.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="509" mass="58241" checksum="EE39B32836FEA49D" modified="2005-04-12" version="1">MPSEKKGMLFCLGCISVIPGIKNQLVNSMSFHPPIIKGYKYSKCGNSIVLFDFHRKRYVTLNEMKKNLINIDPGRCQIQVKFSSINSIDFFYYKNPAAKFTIIYSHSNATDIGYLFGHLLDFSHKACVNIISYEYNGYGQSKKKTSEESLYENIKTIVHYSINHLKLPSSSLILYGQSIGSAPTIHFASTYNSINIAGIIIHSGIKSAVSVICNNTNSKSLPWYDAFKNLEKIQKVKCPVFVIHGTADTVIPFNHGEMLYKLSPNKYTPWYVNGANHCNIELNWRDELISKVRQFILYLSPKPKIQSSKSSYMTHDHTLSISRISTLSSQGFENLYHELDDDDDNDDDDDNIYDNYQEYESTSHEYNTNNNKDSCYYREKSYPIPKNHTNNHLNYHNTTKSSNKYFNNQSSRMKIEENNIISNSSISSKSKFTHSNTYHPNTSNNSHSHNYYSKTLNSAYQTPSSGNNCQISDQVVYGVSIYDDNINLHANMYSGNCRKPKNFTRIFGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQB3</accession>
    <name>Q5CQB3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Putative ABC transporter with AAA domain and 12 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_1390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87614.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625735.1">
        <property type="nucleotide sequence ID" value="XM_625735.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQB3"/>
    <dbReference type="GeneID" id="3372641"/>
    <dbReference type="KEGG" id="cpv:cgd4_1390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1390"/>
    <dbReference type="InParanoid" id="Q5CQB3"/>
    <dbReference type="OMA" id="TIVECAY"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042626">
        <property type="term" value="F:ATPase-coupled transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="100"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="218"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="244"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="367"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="820"/>
            <end position="839"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="860"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="893"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="934"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="960"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1050"/>
            <end position="1068"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1080"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="9">
        <location>
            <begin position="1158"/>
            <end position="1517"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87614.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1522" mass="176017" checksum="75C04515093B3981" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQD1</accession>
    <name>Q5CQD1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin fusion degradation protein (UFD1) double Psi beta barrel fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_1200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the UFD1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625717.1">
        <property type="nucleotide sequence ID" value="XM_625717.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQD1"/>
    <dbReference type="FunCoup" id="Q5CQD1">
        <property type="interactions" value="457"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQD1"/>
    <dbReference type="GeneID" id="3372670"/>
    <dbReference type="KEGG" id="cpv:cgd4_1200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1200"/>
    <dbReference type="InParanoid" id="Q5CQD1"/>
    <dbReference type="OMA" id="WMMQQLC"/>
    <dbReference type="OrthoDB" id="422728at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034098">
        <property type="term" value="C:VCP-NPL4-UFD1 AAA ATPase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.330.10:FF:000002">
        <property type="entry name" value="ubiquitin fusion degradation protein 1 homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.50">
        <property type="entry name" value="Ubiquitin fusion degradation protein UFD1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004854">
        <property type="entry name" value="Ufd1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042299">
        <property type="entry name" value="Ufd1-like_Nn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055417">
        <property type="entry name" value="UFD1_N1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055418">
        <property type="entry name" value="UFD1_N2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555">
        <property type="entry name" value="UBIQUITIN FUSION DEGRADATON PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12555:SF13">
        <property type="entry name" value="UBIQUITIN RECOGNITION FACTOR IN ER-ASSOCIATED DEGRADATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03152">
        <property type="entry name" value="UFD1_N1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24842">
        <property type="entry name" value="UFD1_N2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 1" evidence="4">
        <location>
            <begin position="45"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="Ubiquitin fusion degradation protein UFD1 N-terminal subdomain 2" evidence="5">
        <location>
            <begin position="140"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="267"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="267"/>
            <end position="277"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF24842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="322" mass="36141" checksum="96D74C8D4AD55960" modified="2005-04-12" version="1">MFGFSRFTSGNFFSGGFENDNIHDDFEQINRGGSNFRSSSSNLFINEYSCYPVSFAGRDELEGGNKILLPPSALNQLARRNITWPMLFQISNPAKNKFTHSGVLEFVAEEGTCYMPYWMMQNLELQEGDITSIMNTSLSKGTYVKFMPLSMDFLDISNPKAVLETTLRNFATLTVGDIITIHYNNNSYRINVLETKPNNAISIIETDIQVDFAPPPDYVEDYNKSESRTMTDTNLTASVTSEYSMSNTDSIFSGHCERLDGKPIKLNSSSSLYSNKSGQTNNSNPEPWKTDRIPGGVRTYNEKYQELIKSGRIPGIVGVVKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQF3</accession>
    <name>Q5CQF3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_940</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87644.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625695.1">
        <property type="nucleotide sequence ID" value="XM_625695.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQF3"/>
    <dbReference type="GeneID" id="3372689"/>
    <dbReference type="KEGG" id="cpv:cgd4_940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_940"/>
    <dbReference type="InParanoid" id="Q5CQF3"/>
    <dbReference type="OMA" id="WTLNTEI"/>
    <dbReference type="OrthoDB" id="340395at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="100"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="100"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87644.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="293" mass="31903" checksum="199FF16B56078A84" modified="2005-04-12" version="1">MSKLNEFFEKKKQKSKGLGDLSSTKKPIIGGLKGATGDPNISSVISEGNIDDWSINTDVKDTSDFLISSKNLSVDGLRKPSNSHMVVAVKTSKPDFDSNIWKSKTGDSSGMNGLSLSKKNAGEDEDGKNMNDEEKEKPKETLKYNVRARLAARGQKVDFLNAKDAISSMPTLAAAVATTNKPRGSNLTPLNPVGTSGNDSDALGVATSTNTFTEKQATSTASATIVEQKDNSCESTDMKNEEKHSENDEKSDLEVIKQLRNCNLLYFNKEVVFNCIVDIEQSKLKYSNIVKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQG5</accession>
    <name>Q5CQG5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">UDP-N-acetylglucosamine diphosphorylase</fullName>
            <ecNumber evidence="3">2.7.7.23</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>N-acetyl-alpha-D-glucosamine 1-phosphate + UTP + H(+) = UDP-N-acetyl-alpha-D-glucosamine + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:13509"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57776"/>
            <dbReference type="EC" id="2.7.7.23"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; UDP-N-acetyl-alpha-D-glucosamine biosynthesis; UDP-N-acetyl-alpha-D-glucosamine from N-acetyl-alpha-D-glucosamine 1-phosphate: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the UDPGP type 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.23" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625683.1">
        <property type="nucleotide sequence ID" value="XM_625683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQG5"/>
    <dbReference type="SMR" id="Q5CQG5"/>
    <dbReference type="FunCoup" id="Q5CQG5">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQG5"/>
    <dbReference type="GeneID" id="3372701"/>
    <dbReference type="KEGG" id="cpv:cgd4_810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_810"/>
    <dbReference type="InParanoid" id="Q5CQG5"/>
    <dbReference type="OMA" id="YFQVDNP"/>
    <dbReference type="OrthoDB" id="532420at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003977">
        <property type="term" value="F:UDP-N-acetylglucosamine diphosphorylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006048">
        <property type="term" value="P:UDP-N-acetylglucosamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039741">
        <property type="entry name" value="UDP-sugar_pyrophosphorylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002618">
        <property type="entry name" value="UDPGP_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952:SF2">
        <property type="entry name" value="LD24639P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11952">
        <property type="entry name" value="UDP- GLUCOSE PYROPHOSPHORYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01704">
        <property type="entry name" value="UDPGP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="135"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="141"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048493"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="603" mass="70354" checksum="3A0B45A066A147B0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQK1</accession>
    <name>Q5CQK1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein with possible 2 TPR domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625647.1">
        <property type="nucleotide sequence ID" value="XM_625647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQK1"/>
    <dbReference type="STRING" id="353152.Q5CQK1"/>
    <dbReference type="GeneID" id="3372736"/>
    <dbReference type="KEGG" id="cpv:cgd4_400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_400"/>
    <dbReference type="InParanoid" id="Q5CQK1"/>
    <dbReference type="OMA" id="KGEICPR"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042282">
        <property type="entry name" value="FKBP6/shu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46674">
        <property type="entry name" value="INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46674:SF1">
        <property type="entry name" value="INACTIVE PEPTIDYL-PROLYL CIS-TRANS ISOMERASE FKBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="499" mass="59378" checksum="34D86E8E931E8A31" modified="2005-04-12" version="1">MIESTEFYTEVIQGIDTKLAVIAENETILTEQAILLRKEYEARKKEIDRIISEICDDRVKKIYEKVGSMITTQRKLWSILVNTKISTQEQEENILTEKKQINELILKELNNIEKMYCENSEYINKIEEDWKDVKKASIDGVKLSREIDWDSIPEEELGKRLRGGEVLHRDEWIPTQDNNTGRKLSPAEFKSHLEFGEMILKEGKDQFEKQDFELSYTRYTQGVELLCWVRGSDQESETLRIEMYKKFLKNQALLALKLGKYNDSIQSCNKVLKIDECDEKSIFRRGECYMMLGRFEEAKKDFRYICEFDYFSRDAKLQSRKKLVEMMKKSKSNNYVNKTIINNLDGLMQNNRQEEDKKKVQIQDHYSPAIHHFSSDYQENQTHSTRNEIQPHFDLDTTKDILDEMLFKYSSEEFEKQLFELRKLSDYDEKRFLRRIRNVLPGINTPIYEKYGLDLQSMSYDKAKRIIEESVSYWRTKDDQVKTLSKEIYKYIMGDTIAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQR4</accession>
    <name>Q5CQR4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Immunodominant antigen 23393226</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625938.1">
        <property type="nucleotide sequence ID" value="XM_625938.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQR4"/>
    <dbReference type="SMR" id="Q5CQR4"/>
    <dbReference type="GeneID" id="3372811"/>
    <dbReference type="KEGG" id="cpv:cgd4_3620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3620"/>
    <dbReference type="InParanoid" id="Q5CQR4"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="66"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="90"/>
            <end position="111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="111" mass="11232" checksum="37D530CA878B4AED" modified="2007-04-03" version="1">MGCSSSKPETKVAENKSAADANKQRELAEKKAQLAKAVKNPAPISNQAQQKPEEPKKSEPAPNNPPAADAPAAQAPAAPAEPAPQDKPADAPAAEAPAAEPAAQQDKPADA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQT4</accession>
    <name>Q5CQT4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Vps53-N family protein involved invacuolar protein sorting</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87783.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625918.1">
        <property type="nucleotide sequence ID" value="XM_625918.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQT4"/>
    <dbReference type="STRING" id="353152.Q5CQT4"/>
    <dbReference type="GeneID" id="3372868"/>
    <dbReference type="KEGG" id="cpv:cgd4_3420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3420"/>
    <dbReference type="InParanoid" id="Q5CQT4"/>
    <dbReference type="OMA" id="GNISHYP"/>
    <dbReference type="OrthoDB" id="10261632at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="GOC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000938">
        <property type="term" value="C:GARP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042147">
        <property type="term" value="P:retrograde transport, endosome to Golgi"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039766">
        <property type="entry name" value="Vps53"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007234">
        <property type="entry name" value="Vps53_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820:SF0">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 53 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12820">
        <property type="entry name" value="VACUOLAR SORTING PROTEIN 53"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04100">
        <property type="entry name" value="Vps53_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Vps53 N-terminal" evidence="1">
        <location>
            <begin position="35"/>
            <end position="525"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04100"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87783.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="956" mass="110749" checksum="B4571D157A81F1B7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQU7</accession>
    <name>Q5CQU7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative NLI interacting factor CTD-like phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87795.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625905.1">
        <property type="nucleotide sequence ID" value="XM_625905.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQU7"/>
    <dbReference type="STRING" id="353152.Q5CQU7"/>
    <dbReference type="DNASU" id="3372783"/>
    <dbReference type="GeneID" id="3372783"/>
    <dbReference type="KEGG" id="cpv:cgd4_3240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3240"/>
    <dbReference type="InParanoid" id="Q5CQU7"/>
    <dbReference type="OMA" id="CEMRATE"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="1">
        <location>
            <begin position="200"/>
            <end position="360"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87795.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="392" mass="45434" checksum="C229912B35DB6A89" modified="2005-04-12" version="1">MVTFKYRMKRLRTFANEEIQEELPLKSKLNERLIVERKEDNTLEEKDLNSLGKDFSQNSQSTIESENMEASTLEMSLLKRFDDFMEIMRHLKLNIKPGSFRDDENLLNYCFLISKPFKSNSIGFTFHVAMENIVSGRPRVLSQSMSMAIEYICCTKFPSKLLNGESPTTNSPFKVNDIQNDKSLLKIGNLPLLKTIKEQEVSSGLFIVLDMDETLVHCTNEMLKGVKPDLLVKIATYSTPWFVYYRPFLKFFLQNASKLGSICVFTASTREYAEQVINSIDPTQDLIKYKLFREHCTVYNKGYMKDLRIIQGANLKRTVLVDNSLISNTLQLDNAIPVDSWYGCCKDNELLRLLVLLNRIQLLNDVRPYLASRYGIREWINMNRTKDNLMPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQZ9</accession>
    <name>Q5CQZ9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Serine/threonine-protein kinase ATR</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd4_2670</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PI3/PI4-kinase family. ATM subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87836.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625853.1">
        <property type="nucleotide sequence ID" value="XM_625853.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQZ9"/>
    <dbReference type="GeneID" id="3372843"/>
    <dbReference type="KEGG" id="cpv:cgd4_2670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2670"/>
    <dbReference type="InParanoid" id="Q5CQZ9"/>
    <dbReference type="OMA" id="YNECEIS"/>
    <dbReference type="OrthoDB" id="339600at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000077">
        <property type="term" value="P:DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000723">
        <property type="term" value="P:telomere maintenance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00892">
        <property type="entry name" value="PIKKc_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050517">
        <property type="entry name" value="DDR_Repair_Kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003152">
        <property type="entry name" value="FATC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057564">
        <property type="entry name" value="HEAT_ATR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139">
        <property type="entry name" value="ATAXIA TELANGIECTASIA MUTATED ATM -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11139:SF69">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02260">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23593">
        <property type="entry name" value="HEAT_ATR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01343">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51190">
        <property type="entry name" value="FATC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 14" id="KW-0418">Kinase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="12">
        <location>
            <begin position="3083"/>
            <end position="3398"/>
        </location>
    </feature>
    <feature type="domain" description="FATC" evidence="13">
        <location>
            <begin position="3429"/>
            <end position="3461"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010769"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK87836.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="3461" mass="401160" checksum="222CF5FB1E407B4B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR13</accession>
    <name>Q5CR13_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87848.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625839.1">
        <property type="nucleotide sequence ID" value="XM_625839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR13"/>
    <dbReference type="GeneID" id="3372874"/>
    <dbReference type="KEGG" id="cpv:cgd4_2510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2510"/>
    <dbReference type="InParanoid" id="Q5CR13"/>
    <dbReference type="OrthoDB" id="344211at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="262"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="313"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="340"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="349"/>
            <end position="360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="373"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87848.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="382" mass="43210" checksum="1C5D1134AA883324" modified="2005-04-12" version="1">MFKSIIVISLNFLLFYVNINVMIFPLLLLLLLLISIDFIQCEDFENNKDKIFEAKAAKIGQSNKYNKIEKASSVSNALENSKESLKKINRTANFQILSLGEVYALREFNELGGVNKLIQRPAPSLQRLTYRSIFGKETSGQLRFICMNPHHLSIGERLIIQSSKFSFSVNRNQFVNARSQLSHISIVQNKHNNDLRRALEGLISNAEKTRINKEESKINELDSKQIKGKKKLVIQEDFVKGVIDSIKQEQGLLKEKKLSSNSVDLVIPPPPNKSPDLDFEDNNLDTNNDLKNSTASSRSLFEHLKIPDIEDNVHTSNCLNGEKTPRKLPPGAELELEEFFARQSKRTSGKNSPRASSGYGNKQLILSKHNRSAKNSNPYKPS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR65</accession>
    <name>Q5CR65_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Origin recognition complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_1930</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the origin recognition complex (ORC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the ORC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87888.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625787.1">
        <property type="nucleotide sequence ID" value="XM_625787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR65"/>
    <dbReference type="STRING" id="353152.Q5CR65"/>
    <dbReference type="GeneID" id="3372894"/>
    <dbReference type="KEGG" id="cpv:cgd4_1930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1930"/>
    <dbReference type="InParanoid" id="Q5CR65"/>
    <dbReference type="OMA" id="WETHCCK"/>
    <dbReference type="OrthoDB" id="20198at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007220">
        <property type="entry name" value="ORC2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056772">
        <property type="entry name" value="RecA-like_ORC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14052:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04084">
        <property type="entry name" value="RecA-like_ORC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Origin recognition complex subunit 2 RecA-like" evidence="2">
        <location>
            <begin position="64"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU368084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF04084"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87888.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="355" mass="41005" checksum="A5D6EA1646B10AE9" modified="2005-04-12" version="1">MKGTFSDYLIQSSSSYNLAEELPEVDLQLLKKRNAAIEKKLDKIRREKRSSWNSAHEKLLTWSLSGFSVLIYGFGSKRNFLDEFVKKKINGNYVALTIRGYFKNIKFKTCLFELLKAMDHTEDFLKDSTKSYNNFISNDCSIDSMIAKIQLLYNNSSTYFKNIFLIIHSIDSISIRQYLPAISQLSQLPFMSVIVSVDNIRWPLLWNNSMRCKMNFLYLKVSTFEEYDVELDHLYESQLPPWLGALSDNSREQCKLEQLNSILNCLTPSHIQVVNTIATLQLEYGHAAEDQLLKSLKSSMTVTTKSSLSQLLIELFTHDVLSKQFLNDSENKNGKVIYKLKLSSELIKEYLNNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR82</accession>
    <name>Q5CR82_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_1760</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TAPT1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87903.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625770.1">
        <property type="nucleotide sequence ID" value="XM_625770.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372909"/>
    <dbReference type="KEGG" id="cpv:cgd4_1760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1760"/>
    <dbReference type="InParanoid" id="Q5CR82"/>
    <dbReference type="OMA" id="TMNIPAN"/>
    <dbReference type="OrthoDB" id="29023at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008010">
        <property type="entry name" value="Tatp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13317:SF4">
        <property type="entry name" value="TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05346">
        <property type="entry name" value="DUF747"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="166"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="192"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="383"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="490"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="583"/>
            <end position="604"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87903.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="661" mass="78132" checksum="1490370AABEC7084" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR94</accession>
    <name>Q5CR94_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">D-glutamate cyclase-like C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87909.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625758.1">
        <property type="nucleotide sequence ID" value="XM_625758.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR94"/>
    <dbReference type="GeneID" id="3372925"/>
    <dbReference type="KEGG" id="cpv:cgd4_1620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1620"/>
    <dbReference type="InParanoid" id="Q5CR94"/>
    <dbReference type="OMA" id="EDCITTI"/>
    <dbReference type="OrthoDB" id="336895at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1640.20">
        <property type="entry name" value="TON_0340"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025504">
        <property type="entry name" value="GLUCM_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14336">
        <property type="entry name" value="GLUCM-like_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="D-glutamate cyclase-like C-terminal" evidence="1">
        <location>
            <begin position="107"/>
            <end position="314"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF14336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87909.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="400" mass="45751" checksum="C472DB342035E4DA" modified="2005-04-12" version="1">MTENNINIANVQIVENKEISKLEEVKPLPSYYGDMSQVLTLEEALKQYDQLKLKDTISPRKSIKEYADKLKLSSIAEVSKTLYEISLNNDSDTNNVIGLFALSPNNVSHLPPTEKDGLSGLAVLSNALSNLGFTVVIMTDSINQPVISSILSNNELFKHYVDINQEVGYAPKDLNLEKRKTYVIGVVPDPGIDSEWEEFLDNIQKKFSLLMVLGRPSRELDTGIYRNSRGLRINHYCSNLEGIYIKIMQQENKIPIFAFSDSSENQLGVYQKDDNRSQYNANYIIISHTVDWVCYYLSAGIALRFISNIKKLYADNNNKENSQTVDEINAKMLHDAFQSFFPSEDTFVYLNEKITELEVWDTQYGDNIKKGFTIENDWETRMKIRRIVSQFGVSIEFEHV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRB5</accession>
    <name>Q5CRB5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA-uridine aminocarboxypropyltransferase</fullName>
            <ecNumber evidence="1">2.5.1.25</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_3470</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:62432"/>
            <dbReference type="Rhea" id="RHEA-COMP:13339"/>
            <dbReference type="Rhea" id="RHEA-COMP:16092"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17509"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:82930"/>
            <dbReference type="EC" id="2.5.1.25"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TDD superfamily. DTWD2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.5.1.25" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626271.1">
        <property type="nucleotide sequence ID" value="XM_626271.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRB5"/>
    <dbReference type="GeneID" id="3373098"/>
    <dbReference type="KEGG" id="cpv:cgd5_3470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3470"/>
    <dbReference type="InParanoid" id="Q5CRB5"/>
    <dbReference type="OMA" id="AQMSFGG"/>
    <dbReference type="OrthoDB" id="343463at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016432">
        <property type="term" value="F:tRNA-uridine aminocarboxypropyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005636">
        <property type="entry name" value="DTW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039262">
        <property type="entry name" value="DTWD2/TAPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21392">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21392:SF0">
        <property type="entry name" value="TRNA-URIDINE AMINOCARBOXYPROPYLTRANSFERASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03942">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01144">
        <property type="entry name" value="DTW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <keyword evidence="4" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="DTW" evidence="7">
        <location>
            <begin position="56"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012386"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00034489"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00048718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="323" mass="37623" checksum="D6AA8EEB1885D3B8" modified="2005-04-12" version="1">MGPTKSEDSEVEILNERINSLDLEDLDPREKYSRVVQRRFERSMRELEEREKQGHPFVKCRLCFLVKKDHCICMDLSRLAGKIREAQAYPEIRFIIFMNDREYFRSSNTGKLVNQLIPGSEILIHGIPGSCERLEKILLQDLQSYNETVILYPSKDSKSICEYFLDLKANKYLEISDKKAENTLSSMEFYKKLKLKVILIDGTWSQAKSINKSLPKEIKRIVISSKLISDFGPLRKQNKAGNISTVEAASLLIKDIREILSREIGDDIPTNNISHLNLQSDLLEESLKLLIKHVIAQCKREYLREILESRNERKFSKYKYETL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRJ6</accession>
    <name>Q5CRJ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein with 12 transmembrane domains, possible apicomplexan-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_2530</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TMEM121 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87974.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626190.1">
        <property type="nucleotide sequence ID" value="XM_626190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRJ6"/>
    <dbReference type="GeneID" id="3373156"/>
    <dbReference type="KEGG" id="cpv:cgd5_2530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2530"/>
    <dbReference type="InParanoid" id="Q5CRJ6"/>
    <dbReference type="OMA" id="QFIGYII"/>
    <dbReference type="OrthoDB" id="391274at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032776">
        <property type="entry name" value="CECR6/TMEM121"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14997">
        <property type="entry name" value="CECR6_TMEM121"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="33"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="63"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="102"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="181"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="222"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="551"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="577"/>
            <end position="598"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="618"/>
            <end position="636"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="742"/>
            <end position="762"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="768"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="353"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="353"/>
            <end position="372"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="373"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007711"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87974.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="899" mass="102829" checksum="CA09E6DB510B2631" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRQ5</accession>
    <name>Q5CRQ5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 9">T-complex protein 1 subunit delta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd5_1880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the TCP-1 chaperonin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88237.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626131.1">
        <property type="nucleotide sequence ID" value="XM_626131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRQ5"/>
    <dbReference type="FunCoup" id="Q5CRQ5">
        <property type="interactions" value="583"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRQ5"/>
    <dbReference type="GeneID" id="3373085"/>
    <dbReference type="KEGG" id="cpv:cgd5_1880"/>
    <dbReference type="InParanoid" id="Q5CRQ5"/>
    <dbReference type="OMA" id="HPAANMI"/>
    <dbReference type="OrthoDB" id="10248520at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03338">
        <property type="entry name" value="TCP1_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.7.10:FF:000010">
        <property type="entry name" value="T-complex protein 1 subunit delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.7.10">
        <property type="entry name" value="GroEL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.560.10">
        <property type="entry name" value="GroEL-like equatorial domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.260.10">
        <property type="entry name" value="TCP-1-like chaperonin intermediate domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012717">
        <property type="entry name" value="Chap_CCT_delta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017998">
        <property type="entry name" value="Chaperone_TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002194">
        <property type="entry name" value="Chaperonin_TCP-1_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002423">
        <property type="entry name" value="Cpn60/GroEL/TCP-1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027409">
        <property type="entry name" value="GroEL-like_apical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027413">
        <property type="entry name" value="GROEL-like_equatorial_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027410">
        <property type="entry name" value="TCP-1-like_intermed_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053374">
        <property type="entry name" value="TCP-1_chaperonin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054827">
        <property type="entry name" value="thermosome_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02342">
        <property type="entry name" value="chap_CCT_delta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041082">
        <property type="entry name" value="thermosome_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF041083">
        <property type="entry name" value="thermosome_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11353">
        <property type="entry name" value="CHAPERONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00118">
        <property type="entry name" value="Cpn60_TCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00304">
        <property type="entry name" value="TCOMPLEXTCP1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52029">
        <property type="entry name" value="GroEL apical domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48592">
        <property type="entry name" value="GroEL equatorial domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54849">
        <property type="entry name" value="GroEL-intermediate domain like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00750">
        <property type="entry name" value="TCP1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00751">
        <property type="entry name" value="TCP1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00995">
        <property type="entry name" value="TCP1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88237.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="550" mass="60341" checksum="9EEC9B85F1BAD77C" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRT1</accession>
    <name>Q5CRT1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_1590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88092.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626105.1">
        <property type="nucleotide sequence ID" value="XM_626105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRT1"/>
    <dbReference type="GeneID" id="3373018"/>
    <dbReference type="KEGG" id="cpv:cgd5_1590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1590"/>
    <dbReference type="InParanoid" id="Q5CRT1"/>
    <dbReference type="OrthoDB" id="336654at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88092.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="377" mass="43501" checksum="2D99C61AEA23E3D0" modified="2005-04-12" version="1">MDEIPIVLFTVKEKGSTLFFDAYSQTDSVKQNSSITPREYSNYYRFYVNKYKNYNSINVHSVQSNNDYLKQQLDSSNERNDHYIFSPNKYSGFEVNQLNQSTTILPSAFCGNGISTNLEDYELRNKHLISFAEKQDPSFESPLISSGIHNIHLYGPYLYNRKIYTRFPLNQANIVRECNFKEKLCRTCQYSSLKNIDLYIEQPPKYNFVSNTIPEALSMGIMIGINAIVEVIASIAIKFCARIPDKDELHPGTGCVLMDYLNDRIDRLFNDQIEILDNSTECEQSKNETESSNMNFEAWINNKLDEIINPTNHESSDNRSTFKYTSLYDALIKNCYHKADDSRFDPIEYSDSLPYALPLAGTKAQTLKRGFLDYSKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRX2</accession>
    <name>Q5CRX2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Cinnamyl-alcohol dehydrogenase-like nucleoside diphosphate sugar epimerase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_1140</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88128.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626064.1">
        <property type="nucleotide sequence ID" value="XM_626064.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRX2"/>
    <dbReference type="STRING" id="353152.Q5CRX2"/>
    <dbReference type="GeneID" id="3373070"/>
    <dbReference type="KEGG" id="cpv:cgd5_1140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1140"/>
    <dbReference type="InParanoid" id="Q5CRX2"/>
    <dbReference type="OMA" id="QGQMKEK"/>
    <dbReference type="OrthoDB" id="336148at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016616">
        <property type="term" value="F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05227">
        <property type="entry name" value="AR_SDR_e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.720:FF:000085">
        <property type="entry name" value="Dihydroflavonol reductase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001509">
        <property type="entry name" value="Epimerase_deHydtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050425">
        <property type="entry name" value="NAD(P)_dehydrat-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366">
        <property type="entry name" value="NAD DEPENDENT EPIMERASE/DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10366:SF564">
        <property type="entry name" value="STEROL-4-ALPHA-CARBOXYLATE 3-DEHYDROGENASE, DECARBOXYLATING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01370">
        <property type="entry name" value="Epimerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NAD-dependent epimerase/dehydratase" evidence="4">
        <location>
            <begin position="110"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023445"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88128.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="444" mass="50324" checksum="6432C1830D123D06" modified="2005-04-12" version="1">MTENQGYKQDILSSSTPNMSKENKNEKINTTFDADQDNSTKPIIEKIPLHTEAEYNCCEDVKVKNNADYPIREHNGVNNSHNVSEYAVQGEVYSCMEPLVYDKNNNNTIVLVTGATGFIASHIVERLLLRGYKVRATTRSKNSQNSDSLLNFHFADENLMLYEADLLNSECWKELVKGCRIVIHCASPYKMDCKDPYEIIDPAIIGTKNVIHACCMCDDVKTVVLTSSIAAVVGAYKDGKVYSEIDWNEDCNPLIHPYLYSKVEAEKIAYKVVDECRKSLNLIVVNPGMVIGPSYRSDVNQSVQWIYNMITGRMPLTVDLQTGWVDVRDVAEIHIRLFESGKFSGRFICIEGMYTFLDISRMIKHISPQLNPPNHSLPNFIAKIILPLFASKNEKDFLKTSLGKRILLSNGRLLSHLPNYKFLSTFESVKDTCNDLTNKFDIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRZ8</accession>
    <name>Q5CRZ8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">V-type proton ATPase subunit F</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the V-ATPase F subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88148.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626038.1">
        <property type="nucleotide sequence ID" value="XM_626038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRZ8"/>
    <dbReference type="FunCoup" id="Q5CRZ8">
        <property type="interactions" value="314"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRZ8"/>
    <dbReference type="GeneID" id="3373135"/>
    <dbReference type="KEGG" id="cpv:cgd5_850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_850"/>
    <dbReference type="InParanoid" id="Q5CRZ8"/>
    <dbReference type="OMA" id="IIICQHI"/>
    <dbReference type="OrthoDB" id="10261947at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10580:FF:000004">
        <property type="entry name" value="V-type proton ATPase subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10580">
        <property type="entry name" value="ATPase, V1 complex, subunit F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008218">
        <property type="entry name" value="ATPase_V1-cplx_f_g_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005772">
        <property type="entry name" value="ATPase_V1-cplx_fsu_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036906">
        <property type="entry name" value="ATPase_V1_fsu_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01101">
        <property type="entry name" value="V_ATP_synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861:SF2">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13861">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01990">
        <property type="entry name" value="ATP-synt_F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015945">
        <property type="entry name" value="ATPase_V1_F_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF159468">
        <property type="entry name" value="AtpF-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRNR" id="PIRNR015945"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88148.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="125" mass="13946" checksum="1BA0A23C00171D29" modified="2005-04-12" version="1">MSGQRASTLHNLKIYIIGDEDTVAGFLLTGIGARDPQGKTNFLIVDSKTPQSQIEETFKDFISQQDCGILMINQTIAEEIRYLVNTHDKIIPTILEVPSKDKPYDAAKDSVMQRIKLFYGGSLPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS66</accession>
    <name>Q5CS66_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal peptide containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_50</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625970.1">
        <property type="nucleotide sequence ID" value="XM_625970.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS66"/>
    <dbReference type="GeneID" id="3373338"/>
    <dbReference type="KEGG" id="cpv:cgd5_50"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_50"/>
    <dbReference type="InParanoid" id="Q5CS66"/>
    <dbReference type="OrthoDB" id="344075at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="52"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="482"/>
            <end position="654"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="127"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="482"/>
            <end position="495"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="497"/>
            <end position="508"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="532"/>
            <end position="545"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="560"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="625"/>
            <end position="636"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="654" mass="73158" checksum="07A599FC4C7019FD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSB4</accession>
    <name>Q5CSB4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Katanin p60/fidgetin family AAA ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_3390</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88550.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628153.1">
        <property type="nucleotide sequence ID" value="XM_628153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSB4"/>
    <dbReference type="FunCoup" id="Q5CSB4">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSB4"/>
    <dbReference type="GeneID" id="3371450"/>
    <dbReference type="KEGG" id="cpv:cgd1_3390"/>
    <dbReference type="InParanoid" id="Q5CSB4"/>
    <dbReference type="OMA" id="IEWTNEF"/>
    <dbReference type="OrthoDB" id="29072at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016197">
        <property type="term" value="P:endosomal transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02656">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000043">
        <property type="entry name" value="Vacuolar protein sorting-associated protein 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.80">
        <property type="entry name" value="Phosphotransferase system, lactose/cellobiose-type IIA subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007330">
        <property type="entry name" value="MIT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036181">
        <property type="entry name" value="MIT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015415">
        <property type="entry name" value="Spast_Vps4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF83">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 4A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04212">
        <property type="entry name" value="MIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09336">
        <property type="entry name" value="Vps4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116846">
        <property type="entry name" value="MIT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="167"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="72"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="72"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="88"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88550.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="462" mass="52242" checksum="3CFE8182FDA4A4F8" modified="2005-04-12" version="1" fragment="single">FEMINNILDLIKQGTEKEKIGNLEEALNIYISALQKWDHICKYQNDERVKKVLLTRMEQLVSRAEQIKNLINNNGKGSKTISNPNLASTSTPGLSSSSSSENISKSSQNPSNINDPLKDAIRSCILMESPNISWDDIIGLEQAKTSLKEAVILPAKFPELFQGKLKPWKGILLYGPPGTGKTFLAKACATEMKGTFLSISSADLTSKWQGESEKLIKALFDVARERAPSIIFIDEIDSLCSSRNEQENEATRRIKTEFLVQMDGVNSNSNNNNFKPILVLGTTNIPWEIDSGIRRRFERRIYIPLPDEESRVLLIKNGLKSINHSLIDDDINYIAKMTHGYSSSDVSILIKDALFEPIRKCSESNWFKKVVIMNNNDEITNNNAENFKIYWTPCSQPSNIDHYDKELYRKTSLYDIPNNQLLPPKLTKSDLIHVLSKTKSSITNLDIDKFTEWTNKFGLSGE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSC9</accession>
    <name>Q5CSC9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Erythrocyte membrane-associated antigen</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_3220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628138.1">
        <property type="nucleotide sequence ID" value="XM_628138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSC9"/>
    <dbReference type="STRING" id="353152.Q5CSC9"/>
    <dbReference type="GeneID" id="3371460"/>
    <dbReference type="KEGG" id="cpv:cgd1_3220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3220"/>
    <dbReference type="InParanoid" id="Q5CSC9"/>
    <dbReference type="OrthoDB" id="343497at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="323"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="525"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="537"/>
            <end position="546"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="547"/>
            <end position="561"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="646"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="673" mass="75941" checksum="F7F5DB2DF215373D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSJ3</accession>
    <name>Q5CSJ3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">tRNA carboxymethyluridine synthase</fullName>
            <ecNumber evidence="14">2.3.1.311</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">cgd1_2450</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="15">
            <text>uridine(34) in tRNA + acetyl-CoA + S-adenosyl-L-methionine + H2O = 5-(carboxymethyl)uridine(34) in tRNA + 5'-deoxyadenosine + L-methionine + CoA + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:61020"/>
            <dbReference type="Rhea" id="RHEA-COMP:10407"/>
            <dbReference type="Rhea" id="RHEA-COMP:11727"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17319"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57844"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74882"/>
            <dbReference type="EC" id="2.3.1.311"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="15">
            <dbReference type="Rhea" id="RHEA:61021"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">tRNA modification.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the ELP3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.311" evidence="14"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88373.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628074.1">
        <property type="nucleotide sequence ID" value="XM_628074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSJ3"/>
    <dbReference type="FunCoup" id="Q5CSJ3">
        <property type="interactions" value="392"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSJ3"/>
    <dbReference type="GeneID" id="3371702"/>
    <dbReference type="KEGG" id="cpv:cgd1_2450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2450"/>
    <dbReference type="InParanoid" id="Q5CSJ3"/>
    <dbReference type="OMA" id="RANQNGW"/>
    <dbReference type="OrthoDB" id="10265243at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033588">
        <property type="term" value="C:elongator holoenzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106261">
        <property type="term" value="F:tRNA uridine(34) acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002926">
        <property type="term" value="P:tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039661">
        <property type="entry name" value="ELP3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034687">
        <property type="entry name" value="ELP3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006638">
        <property type="entry name" value="Elp3/MiaA/NifB-like_rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032432">
        <property type="entry name" value="Radical_SAM_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007197">
        <property type="entry name" value="rSAM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058240">
        <property type="entry name" value="rSAM_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135:SF2">
        <property type="entry name" value="ELONGATOR COMPLEX PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11135">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04055">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16199">
        <property type="entry name" value="Radical_SAM_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01086">
        <property type="entry name" value="elongater_protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00344">
        <property type="entry name" value="ELP3-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00029">
        <property type="entry name" value="Radical_SAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00729">
        <property type="entry name" value="Elp3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102114">
        <property type="entry name" value="Radical SAM enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="13" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="11" id="KW-0408">Iron</keyword>
    <keyword evidence="12" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="17" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6 19" id="KW-0808">Transferase</keyword>
    <keyword evidence="17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="8" id="KW-0819">tRNA processing</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="domain" description="Elp3/MiaA/NifB-like radical SAM core" evidence="18">
        <location>
            <begin position="188"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="566"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="16">
        <location>
            <begin position="584"/>
            <end position="597"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005494"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00044771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00047372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAK88373.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="915" mass="105793" checksum="E6B8DD592AC146F1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSJ5</accession>
    <name>Q5CSJ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">ARP3 actin related protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88375.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628072.1">
        <property type="nucleotide sequence ID" value="XM_628072.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSJ5"/>
    <dbReference type="STRING" id="353152.Q5CSJ5"/>
    <dbReference type="GeneID" id="3371704"/>
    <dbReference type="KEGG" id="cpv:cgd1_2430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2430"/>
    <dbReference type="InParanoid" id="Q5CSJ5"/>
    <dbReference type="OMA" id="YHERIDW"/>
    <dbReference type="OrthoDB" id="337660at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88375.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="311" mass="35360" checksum="35C25C5505A5754E" modified="2005-04-12" version="1">MNPFDFPIVIDTGQFQTRIGSSINKLPQIIIDTILFEKIEVKEINFDKKIFSDKLGISEHCIETKSLSSSNNWNPQKKSLLVNDYQDITHPFNYLDGLDWNLLETFWTDIISREMCYDTTMCPVLLSEPHNAPFDFQDHSMEFFFESLSVPSFNCISQELLSVDAVQRGLPNIFHKSNSKGSVGIIVHFGDSSIRILPIASGYLLSDYIGIINLGGYSITNSLFDNFKTNFKSSSPITHKNIDSIKSYGIFDGIITKMAIPYICDEIISVARKCPVDYLRLLLKNIIFIGGSSINSLLSTYFKNYFKVRFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSL0</accession>
    <name>Q5CSL0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Small nuclear ribonucleoprotein Sm D3</fullName>
            <shortName evidence="9">Sm-D3</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">snRNP core protein D3</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd1_2250</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88565.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628057.1">
        <property type="nucleotide sequence ID" value="XM_628057.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSL0"/>
    <dbReference type="FunCoup" id="Q5CSL0">
        <property type="interactions" value="515"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSL0"/>
    <dbReference type="GeneID" id="3371353"/>
    <dbReference type="KEGG" id="cpv:cgd1_2250"/>
    <dbReference type="InParanoid" id="Q5CSL0"/>
    <dbReference type="OMA" id="HTITCET"/>
    <dbReference type="OrthoDB" id="6425924at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01721">
        <property type="entry name" value="Sm_D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000002">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034099">
        <property type="entry name" value="SmD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="10">
        <location>
            <begin position="27"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88565.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="143" mass="15967" checksum="A29D929BB3F98D9D" modified="2005-04-12" version="1" fragment="single">SPLQLCIYYKKNFLAQFTFHINMTIGIPLKLLYEGLGHIVTIELKSGDLYRGTLTHVEDNMNCMLEHVNATMRDGKPVSLEQCYLRGSQIRFCILPDMLKNAPMFKLAANAKNRASVLGAAGNKKAFAARFISRGTSRGRSGR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSN7</accession>
    <name>Q5CSN7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Large protein with a SPRY domain and HECT domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_1920</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88406.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628030.1">
        <property type="nucleotide sequence ID" value="XM_628030.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSN7"/>
    <dbReference type="GeneID" id="3371657"/>
    <dbReference type="KEGG" id="cpv:cgd1_1920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1920"/>
    <dbReference type="InParanoid" id="Q5CSN7"/>
    <dbReference type="OMA" id="YFSYAYI"/>
    <dbReference type="OrthoDB" id="338911at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12885">
        <property type="entry name" value="SPRY_RanBP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.920">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001870">
        <property type="entry name" value="B30.2/SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043136">
        <property type="entry name" value="B30.2/SPRY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044736">
        <property type="entry name" value="Gid1/RanBPM/SPLA_SPRY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042469">
        <property type="entry name" value="HECTD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003877">
        <property type="entry name" value="SPRY_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00622">
        <property type="entry name" value="SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50188">
        <property type="entry name" value="B302_SPRY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="B30.2/SPRY" evidence="3">
        <location>
            <begin position="1896"/>
            <end position="2117"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="4">
        <location>
            <begin position="4151"/>
            <end position="4605"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="2">
        <location>
            <position position="4573"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88406.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="4612" mass="538215" checksum="385F384A96F67B58" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSP4</accession>
    <name>Q5CSP4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Chromatin assembly factor 1 subunit A dimerization domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_1840</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628023.1">
        <property type="nucleotide sequence ID" value="XM_628023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSP4"/>
    <dbReference type="STRING" id="353152.Q5CSP4"/>
    <dbReference type="GeneID" id="3371666"/>
    <dbReference type="KEGG" id="cpv:cgd1_1840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1840"/>
    <dbReference type="InParanoid" id="Q5CSP4"/>
    <dbReference type="OMA" id="REEHIDY"/>
    <dbReference type="OrthoDB" id="360074at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022043">
        <property type="entry name" value="CAF1A_DD"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12253">
        <property type="entry name" value="CAF1A_dimeriz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromatin assembly factor 1 subunit A dimerization" evidence="2">
        <location>
            <begin position="465"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="868"/>
            <end position="911"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF12253"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="932" mass="107463" checksum="A28DFA19623A01A6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT33</accession>
    <name>Q5CT33_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Alpha-1,3/1,6-mannosyltransferase ALG2</fullName>
            <ecNumber evidence="3">2.4.1.132</ecNumber>
            <ecNumber evidence="3">2.4.1.257</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>a beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19511"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:58472"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="EC" id="2.4.1.132"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:29516"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an alpha-D-Man-(1-&gt;3)-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + GDP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:29519"/>
            <dbReference type="Rhea" id="RHEA-COMP:19513"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132510"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="EC" id="2.4.1.257"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="3">
            <dbReference type="Rhea" id="RHEA:29520"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the glycosyltransferase group 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.132" evidence="3"/>
    <dbReference type="EC" id="2.4.1.257" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88595.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627884.1">
        <property type="nucleotide sequence ID" value="XM_627884.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT33"/>
    <dbReference type="STRING" id="353152.Q5CT33"/>
    <dbReference type="GeneID" id="3371383"/>
    <dbReference type="KEGG" id="cpv:cgd1_230"/>
    <dbReference type="InParanoid" id="Q5CT33"/>
    <dbReference type="OMA" id="AMYMKCP"/>
    <dbReference type="OrthoDB" id="448893at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004378">
        <property type="term" value="F:GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0102704">
        <property type="term" value="F:GDP-Man:Man(2)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd03805">
        <property type="entry name" value="GT4_ALG2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027054">
        <property type="entry name" value="ALG2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918">
        <property type="entry name" value="ALPHA-1,3/1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45918:SF1">
        <property type="entry name" value="ALPHA-1,3_1,6-MANNOSYLTRANSFERASE ALG2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 3 5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="94"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="4">
        <location>
            <begin position="246"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88595.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="474" mass="54653" checksum="CCA12D3FBC27EE88" modified="2005-04-12" version="1" fragment="single">RVSSSSLLFDRMKPIKRVAVTHLECGIGGAEQLMVLASLALQSYKSSNEKIELTLFTSYHDKSHSFSATNDGRIKVKVYGNWIPRTFFGYGTTLFSYIRIIYTSLIMFFFVMMTSFSLEKTSRYYDVILNDQVSVINPILKLMTRRLIFYCHFPDQLLVRKRDGSLRKMYRYVMDFLEEFGMRYCDYVFVNSIFTRKVYIETFKGLISNANKYPLTLSYPEVLYPPVNLEDIPSEEECENCFSNSKIPQQLNRAPNVPFFLSLNRYERKKNIELAIKSFAILRDQYKPGEKLCLVISGGYDKRVSENIEYFEELLRLANSYAFNVYIGNECIESTDSCFSVVFLRSISDSLRWSLLRKSIGLLYTPENEHFGMVPCEAMSVGTCVIACNSGGPTETIVHGKTGFLCEPNPENFAIRMNELIKISRDSIESSVWSSSCKERVTALFSQSIFQKRLCEVAYSNETKSKVFKKIKHL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT35</accession>
    <name>Q5CT35_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627882.1">
        <property type="nucleotide sequence ID" value="XM_627882.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT35"/>
    <dbReference type="GeneID" id="3371426"/>
    <dbReference type="KEGG" id="cpv:cgd1_210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_210"/>
    <dbReference type="InParanoid" id="Q5CT35"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="32"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="165" mass="18955" checksum="A24A4A75A9F9C37C" modified="2005-04-12" version="1">MYGFIKFFVGFCIPAYHSIFALKTQNHHLIKIWLVYFFTVVFYELILSFILDPIFKVIDSRLLYFKTLFVVLYIFPETGFQESYFSFFSNYLSKLFIQVFEYIKKISLPKTDLSEETSASSSPAPSIPEEGDIKGITCLKESISEGTTLAPNTPLGKLTTDFILS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTA0</accession>
    <name>Q5CTA0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Possible FH2 formin homology domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_3850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626569.1">
        <property type="nucleotide sequence ID" value="XM_626569.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTA0"/>
    <dbReference type="STRING" id="353152.Q5CTA0"/>
    <dbReference type="GeneID" id="3373405"/>
    <dbReference type="KEGG" id="cpv:cgd2_3850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3850"/>
    <dbReference type="InParanoid" id="Q5CTA0"/>
    <dbReference type="OMA" id="NDEDYTC"/>
    <dbReference type="OrthoDB" id="344093at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.2220">
        <property type="entry name" value="Formin, FH2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015425">
        <property type="entry name" value="FH2_Formin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042201">
        <property type="entry name" value="FH2_Formin_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02181">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51444">
        <property type="entry name" value="FH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FH2" evidence="3">
        <location>
            <begin position="315"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="85"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="735"/>
            <end position="761"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="838"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="14"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="166"/>
            <end position="178"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51444"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1189" mass="133353" checksum="996C449FBA56B7CC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTJ3</accession>
    <name>Q5CTJ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Peptidase'insulinase-like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_2760</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88724.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626476.1">
        <property type="nucleotide sequence ID" value="XM_626476.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTJ3"/>
    <dbReference type="SMR" id="Q5CTJ3"/>
    <dbReference type="STRING" id="353152.Q5CTJ3"/>
    <dbReference type="GeneID" id="3373468"/>
    <dbReference type="KEGG" id="cpv:cgd2_2760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2760"/>
    <dbReference type="InParanoid" id="Q5CTJ3"/>
    <dbReference type="OMA" id="TTSHICG"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF33">
        <property type="entry name" value="STROMAL PROCESSING PEPTIDASE, CHLOROPLASTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="1">
        <location>
            <begin position="206"/>
            <end position="420"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88724.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="681" mass="77869" checksum="8725C8BC82087E1A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTM8</accession>
    <name>Q5CTM8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2370</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88762.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626441.1">
        <property type="nucleotide sequence ID" value="XM_626441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTM8"/>
    <dbReference type="GeneID" id="3373506"/>
    <dbReference type="KEGG" id="cpv:cgd2_2370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2370"/>
    <dbReference type="InParanoid" id="Q5CTM8"/>
    <dbReference type="OrthoDB" id="77828at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88762.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="134" mass="15856" checksum="C9F70E545EECCF82" modified="2005-04-12" version="1">MESLWWLNIFEKFIKEKMSISIPSDNILNGELIKSSSFNKIGRFELISQLNNQYFSCFCRRCHKIINNAKLIPNNSRYEIISRMIVSALNRFRGLFRCSETNKLNKEDIQFIINRILITNCEINNVLREVPVSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTT2</accession>
    <name>Q5CTT2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Inhibitor of growth protein N-terminal histone-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_1680</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88807.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626387.1">
        <property type="nucleotide sequence ID" value="XM_626387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTT2"/>
    <dbReference type="GeneID" id="3373748"/>
    <dbReference type="KEGG" id="cpv:cgd2_1680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1680"/>
    <dbReference type="InParanoid" id="Q5CTT2"/>
    <dbReference type="OMA" id="CKIYLET"/>
    <dbReference type="OrthoDB" id="5411773at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="CDD" id="cd16857">
        <property type="entry name" value="ING_ING1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1740">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024610">
        <property type="entry name" value="ING_N_histone-binding"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12998">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01408">
        <property type="entry name" value="ING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Inhibitor of growth protein N-terminal histone-binding" evidence="3">
        <location>
            <begin position="4"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="123"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="180"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="123"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="188"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="221"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM01408"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88807.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="336" mass="38128" checksum="5FBFE1146D29B9CF" modified="2005-04-12" version="1">MSESHEIFMEDISLLPGWILRNLSLMREIDKKSNDLQITLEEKRGKYLKELSKVANSDSQNIDKNASIFKIDEINELQRELKALLKEKIAISDQSVHYIRYDGEILKKHYEQLRESFTENFINNNDSGSSNSYSGRNSLQGQINFKNPGSNNTINNIANNLNGNELNTCRNSISETYNSNDNWNNESHNGDKNIESHNKPSFAHESISRASKRRRSSAATHIKDTFDQISKKPNAFVGTSTSQKSDQNNLSNDNQNQLCSICEGIELINNKFVKCECCSNNMHATCSWSSNPFLCRKCCKKSSIQPSITYDIEYSASLINTPKSDNTKISKGSRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTV0</accession>
    <name>Q5CTV0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Transcription initiation factor TFIID subunit 8</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1470</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88823.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626369.1">
        <property type="nucleotide sequence ID" value="XM_626369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTV0"/>
    <dbReference type="GeneID" id="3373725"/>
    <dbReference type="KEGG" id="cpv:cgd2_1470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1470"/>
    <dbReference type="InParanoid" id="Q5CTV0"/>
    <dbReference type="OMA" id="AWESVIN"/>
    <dbReference type="OrthoDB" id="436852at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00076">
        <property type="entry name" value="HFD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88823.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="188" mass="21585" checksum="BE98AEB422E21CCA" modified="2005-04-12" version="1">MKKNPENIEYYTDHINKKITNSISNSIRLLLRKFDVELDDPNILDTATEAYINYIELLGKISSSIAIAAGRTQVNIVDIKKSIKSLDIKRYEQVFLDSELESTINKKNNFGTNFLKRTIPDICTNGNSLWRDVLNDTNNANKKSLDPELFEYVDSIPKHIPDFLPIFPPRLDYCDKFISSQCSNGKDF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTW2</accession>
    <name>Q5CTW2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">DNAJ protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_1330</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626357.1">
        <property type="nucleotide sequence ID" value="XM_626357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTW2"/>
    <dbReference type="SMR" id="Q5CTW2"/>
    <dbReference type="FunCoup" id="Q5CTW2">
        <property type="interactions" value="238"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTW2"/>
    <dbReference type="GeneID" id="3373416"/>
    <dbReference type="KEGG" id="cpv:cgd2_1330"/>
    <dbReference type="InParanoid" id="Q5CTW2"/>
    <dbReference type="OMA" id="MATDYYA"/>
    <dbReference type="OrthoDB" id="10256793at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031072">
        <property type="term" value="F:heat shock protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042026">
        <property type="term" value="P:protein refolding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10719">
        <property type="entry name" value="DnaJ_zf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.230.10">
        <property type="entry name" value="Heat shock protein DnaJ, cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001305">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036410">
        <property type="entry name" value="HSP_DnaJ_Cys-rich_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43096:SF52">
        <property type="entry name" value="DNAJ HOMOLOG 1, MITOCHONDRIAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00684">
        <property type="entry name" value="DnaJ_CXXCXGXG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57938">
        <property type="entry name" value="DnaJ/Hsp40 cysteine-rich domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51188">
        <property type="entry name" value="ZF_CR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0143">Chaperone</keyword>
    <keyword evidence="1 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 6" id="KW-0862">Zinc</keyword>
    <keyword evidence="3 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="J" evidence="7">
        <location>
            <begin position="80"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="CR-type" evidence="8">
        <location>
            <begin position="222"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="CR-type" evidence="6">
        <location>
            <begin position="222"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00546"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51188"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="457" mass="51383" checksum="60602303AB38160B" modified="2005-04-12" version="1" fragment="single">IFTNYRFIYLNVYHNNSSDGSCLCEMMREVCSRSLKFGQILSRSIFQQLNVSFNGKCLFYGALFNLSNRIFFKSITYSSDPYKVLGVSRNASDEEIKLKFKELAKKYHPDLNPSEEAKNKMAKIVNAYETLSDSKKRKQFSNSGIGQAGQKYNIYKDSKTKQAFNWFEDSPWMTPNIDEIFMSSSFFDNLFGLGEYFMREKQILRKNIYLNIEVDILDAINGTNRTLKTNSSCKCDACNGAGIIKGLKLAKCSNCGGSGLNVYHNGPLLIKSLCMKCSGTGYSNLMLCIKCNGSGHIIKDKNVFLRIPRGTKDGTQLKLSSEGNFVSGNYGDLFIKVNIKPNTKFKWIKDNIHVDIPISINTCIFGGEIVVPSLIKGTSMRVKVPPKTNPRVPYILKGKGPPIFGKDTFGDYIIHFSTRNSHPDLFKNYKESIGIKDKLLSILGELNKKVSKKASKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTZ9</accession>
    <name>Q5CTZ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Drosophila CG6013 like HMG domain containing protein with a coiled coil region at the N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CCDC124 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88863.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626320.1">
        <property type="nucleotide sequence ID" value="XM_626320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTZ9"/>
    <dbReference type="FunCoup" id="Q5CTZ9">
        <property type="interactions" value="48"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTZ9"/>
    <dbReference type="GeneID" id="3373606"/>
    <dbReference type="KEGG" id="cpv:cgd2_870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_870"/>
    <dbReference type="InParanoid" id="Q5CTZ9"/>
    <dbReference type="OMA" id="FEERMMP"/>
    <dbReference type="OrthoDB" id="76412at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010422">
        <property type="entry name" value="Ccdc124/Oxs1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054414">
        <property type="entry name" value="Ccdc124/Oxs1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036910">
        <property type="entry name" value="HMG_box_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21680:SF0">
        <property type="entry name" value="COILED-COIL DOMAIN-CONTAINING PROTEIN 124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06244">
        <property type="entry name" value="Ccdc124"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47095">
        <property type="entry name" value="HMG-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coiled-coil" evidence="4">
        <location>
            <begin position="130"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="11"/>
            <end position="69"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF06244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88863.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="227" mass="26327" checksum="18F47678A1489D35" modified="2005-04-12" version="1">MGYGGMNQKALEARERKQAAALEKKRKEEERAENEKWRDDDKHANRKIERRKEALNKQEEKQQKKQELKKLYEEEDSKIISNKAKTATGNKLTKAEIAKRTLMFAMQSSSGISRNKSEESGYDDLLVENPNRIEKELRIETESKNIEYISASTLDEALLALGVDDKQSADMHPEKRQKAAWLAYVDNNLPILKNENPTLKRSQLLQMLQKNWKKSPENPMNENPKLT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU17</accession>
    <name>Q5CU17_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626302.1">
        <property type="nucleotide sequence ID" value="XM_626302.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU17"/>
    <dbReference type="GeneID" id="3373379"/>
    <dbReference type="KEGG" id="cpv:cgd2_660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_660"/>
    <dbReference type="InParanoid" id="Q5CU17"/>
    <dbReference type="OMA" id="NIHMITI"/>
    <dbReference type="OrthoDB" id="342881at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="442" mass="51614" checksum="FC621F64960E7938" modified="2005-04-12" version="1">MVKYEKSTLTIIFNIIIFLYLLSSFNIIRCNGEKMAHFELNSVETISRSLKNTIFVDNLEKVNFPLANDGFSPGPKVYILKELLQNHREVKKLYKILRKMLIKFYIEEFGIILTYHMSQIEEIKLMGIDTNGYFRLINHQQKPIKKKLPKLSKKMIKKSQFAKTNTLEDFGLMTKDSDAKNKQDEHSTFIENEASQIEFLSARPISFLKMKNSNTNIDAFGNKRSLKKLHMINSKVNKQVAFCKCKSDHKLHLKLIMIAQSLLFVINNAIDTNSTPWYSMPDFIALLLEDILRITSIMKFIGPNFKQFKSIKEYYKYSKKHIKKSQKKHFLKFFSDRRNNYQTNFLLQILGITISFFGNIFNSFIEDFRNSHSASDLATQIEISNANDLKKKNSMIKISKQDIIFISEYIERLPNKNNCIIYPMIENISISAPNQKSIFSLC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU57</accession>
    <name>Q5CU57_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Anaphase-promoting complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_4130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626957.1">
        <property type="nucleotide sequence ID" value="XM_626957.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU57"/>
    <dbReference type="GeneID" id="3373893"/>
    <dbReference type="KEGG" id="cpv:cgd3_4130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4130"/>
    <dbReference type="InParanoid" id="Q5CU57"/>
    <dbReference type="OMA" id="CIKEIAS"/>
    <dbReference type="OrthoDB" id="340237at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="863" mass="98912" checksum="E7ED9486EF0BB053" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU60</accession>
    <name>Q5CU60_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Ribosome biogenesis protein NSA2 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_4100</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">Component of the pre-66S ribosomal particle.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
            <location evidence="1 6">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88959.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626954.1">
        <property type="nucleotide sequence ID" value="XM_626954.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU60"/>
    <dbReference type="FunCoup" id="Q5CU60">
        <property type="interactions" value="486"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU60"/>
    <dbReference type="GeneID" id="3373897"/>
    <dbReference type="KEGG" id="cpv:cgd3_4100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4100"/>
    <dbReference type="InParanoid" id="Q5CU60"/>
    <dbReference type="OMA" id="TNTPEND"/>
    <dbReference type="OrthoDB" id="1847590at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030684">
        <property type="term" value="C:preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11381">
        <property type="entry name" value="NSA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.10.310:FF:000001">
        <property type="entry name" value="NSA2, ribosome biogenesis homolog"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.10.310">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039411">
        <property type="entry name" value="NSA2_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022309">
        <property type="entry name" value="Ribosomal_Se8/biogenesis_NSA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12642">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN NSA2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01201">
        <property type="entry name" value="Ribosomal_S8e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="7" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4 6" id="KW-0698">rRNA processing</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005424"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU367114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88959.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="260" mass="30334" checksum="0471170C7389E3F6" modified="2005-04-12" version="1">MPQNEYIELHRKRHGYRFDHFEKKRKFESRKVHKDSQHAQKLRGIKAKLYNKKRYAEKATLRKLVKANEEKDAVEKDPENVQKGAVPSYLLDREGVNRTKILSNMIKQKRKEKSAKWQVPIPKIKALNEDEMFKILRTGKRQKKSWKRVVNKVCFVGNDFTRKPPKLERYIRPTGLRFKKAHVTHPELKTTFYLDIVSIKKNPQSQLYTTLGVITKGTIIEVNVSELGLVTQTGKVVWAKYAQVTNNPEIDGCINAVLLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU98</accession>
    <name>Q5CU98_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase II subunit beta</fullName>
            <shortName evidence="2">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_3670</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88980.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626916.1">
        <property type="nucleotide sequence ID" value="XM_626916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU98"/>
    <dbReference type="FunCoup" id="Q5CU98">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU98"/>
    <dbReference type="GeneID" id="3373859"/>
    <dbReference type="KEGG" id="cpv:cgd3_3670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3670"/>
    <dbReference type="InParanoid" id="Q5CU98"/>
    <dbReference type="OMA" id="QYLLMTY"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000005">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88980.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="252" mass="28946" checksum="77FE6A936FD5A612" modified="2005-04-12" version="1">MDNTSEPGDSMEYSFSGNELDYEEEASWIEWFCSLKRSEFFIEVDDEYIMDDFNLTGLNEHVIYYDDALDMILDRIDDDFSEDEISAIESSAQLLYGLIHARYILTSKGMHLLFEKYQTQKYGLCPNVSCNNFPLLPIGLSDLPNVNSCKVYCATCNEVYNPKSTRLASIDGAFFGTSFAPLFALQYGLVTSKNKSPQYYVPRIYGFAVYRNKRDLLAEEAEAELEAETESNEFKKDFKGESRLLIQKKNSR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUB6</accession>
    <name>Q5CUB6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_3470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the PCNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88996.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626898.1">
        <property type="nucleotide sequence ID" value="XM_626898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUB6"/>
    <dbReference type="FunCoup" id="Q5CUB6">
        <property type="interactions" value="52"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUB6"/>
    <dbReference type="GeneID" id="3374118"/>
    <dbReference type="KEGG" id="cpv:cgd3_3470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3470"/>
    <dbReference type="InParanoid" id="Q5CUB6"/>
    <dbReference type="OMA" id="KERTADY"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.70.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2 4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="5">
        <location>
            <begin position="1"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="6">
        <location>
            <begin position="131"/>
            <end position="259"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88996.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="261" mass="29713" checksum="A10BD669BB24F994" modified="2005-04-12" version="1">MFEARLQNAMLFKKIAEALKELCHDINIDCDSDGLHLQAMDSSHVALVSLNIQPDAFEHYRCDRPVVLGLDMQQLSKFMKFCDKDTSMTLKKYDDNEDNRITMCFEDNSGILSSKECTLRLMDIEQEHISIPEEEYECNVTMPSNLFQSIVRDMSGIGDEVSLEISGKNIKFCVDGDDGKIDLNFPLNDSPDITKAVQIHADDTISQKYALRYLSYFTKASPLSTTVNISISKGVPLRLQFPLNDKYEHGNMQFYLAPKLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUE4</accession>
    <name>Q5CUE4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Replication factor RFC3 AAA+ ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_3170</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the activator 1 small subunits family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626870.1">
        <property type="nucleotide sequence ID" value="XM_626870.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUE4"/>
    <dbReference type="FunCoup" id="Q5CUE4">
        <property type="interactions" value="278"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUE4"/>
    <dbReference type="GeneID" id="3373772"/>
    <dbReference type="KEGG" id="cpv:cgd3_3170"/>
    <dbReference type="InParanoid" id="Q5CUE4"/>
    <dbReference type="OMA" id="AEDNLPW"/>
    <dbReference type="OrthoDB" id="4199794at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005663">
        <property type="term" value="C:DNA replication factor C complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003689">
        <property type="term" value="F:DNA clamp loader activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000129">
        <property type="entry name" value="Replication factor C subunit 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.272.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008921">
        <property type="entry name" value="DNA_pol3_clamp-load_cplx_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050238">
        <property type="entry name" value="DNA_Rep/Repair_Clamp_Loader"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013748">
        <property type="entry name" value="Rep_factorC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669">
        <property type="entry name" value="REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11669:SF9">
        <property type="entry name" value="REPLICATION FACTOR C SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08542">
        <property type="entry name" value="Rep_fac_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48019">
        <property type="entry name" value="post-AAA+ oligomerization domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="44"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005378"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="383" mass="43492" checksum="0DBA7F834136457A" modified="2005-04-12" version="1" fragment="single">LRFTFKMEEAQLPWVEKYRPSGLQDLLSHKDIINTIEKFISSGQLPHLLFHGPPGTGKTSTIHAISKCIYKDRKYQMVLELNASDDRGINVVRDAIKSFSESASTTLNHSGGTNSNIEDIEMSDVSTRNLDCNKSLCENIKLIILDEADMMTSTAQMALRRIMERYSEHVRFCIICNYVNKITPALQSRCTRFRFSPLPIEDIRNRISEIALSERIFITREGQESLIKSSRGDMRKVLNVLQSCSMSNYGNIEKHKDSGELNGASIEGLITYINEEMIHRILGIPTKSELDYIFGILSRESFSSGFSALQNSQNENGYSTQDFVNGLYSKSMEANWPDEVVPLLMRRLADIEYRLSRGASESIQLAAIVSCFHEVRMEMEKLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUE5</accession>
    <name>Q5CUE5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Transmembrane protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_3160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89019.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626869.1">
        <property type="nucleotide sequence ID" value="XM_626869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUE5"/>
    <dbReference type="STRING" id="353152.Q5CUE5"/>
    <dbReference type="GeneID" id="3373879"/>
    <dbReference type="KEGG" id="cpv:cgd3_3160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3160"/>
    <dbReference type="InParanoid" id="Q5CUE5"/>
    <dbReference type="OMA" id="CLSHPMV"/>
    <dbReference type="OrthoDB" id="306953at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="94"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89019.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="311" mass="36634" checksum="07C31881B76AAAD7" modified="2005-04-12" version="1">MTPEEAQKEFLEYDWSKSTLWQQYYNNLYPTPSASQLTTFKRKWFKKNVNPNLEIQLKEHNYNKYQEESKFSSFNSQAKSNESKLLLSTGYKQWMILSLSISLLISSIIPILNFLPIIRGSKFTYLLVRISSLFYILGLGSHLYDISIKPIKLLSIDFWQKILIEESFHSLISVVAYFGLIYSFPMIFFIPAITSLFIVSKYQPIVNNIQIINIFDLANKNKNKLYQRKAYFEVFVVGIYIFFAVLTRRISIVYISIYWSLIRLKYPIDPFVQYAFRVANSQINGFMKSYSNYIPGFIPRSYNWVSSNKVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUF8</accession>
    <name>Q5CUF8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_2990</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626856.1">
        <property type="nucleotide sequence ID" value="XM_626856.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUF8"/>
    <dbReference type="SMR" id="Q5CUF8"/>
    <dbReference type="GeneID" id="3374096"/>
    <dbReference type="KEGG" id="cpv:cgd3_2990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2990"/>
    <dbReference type="InParanoid" id="Q5CUF8"/>
    <dbReference type="OMA" id="HANEYVQ"/>
    <dbReference type="OrthoDB" id="343129at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254526" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1070"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="396"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="441"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="489"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1005"/>
            <end position="1027"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1070" mass="121158" checksum="1C6F19659F30F248" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUF9</accession>
    <name>Q5CUF9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved COOH terminal-specific cysteine rich domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_2980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the WD repeat mio family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89033.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626855.1">
        <property type="nucleotide sequence ID" value="XM_626855.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUF9"/>
    <dbReference type="STRING" id="353152.Q5CUF9"/>
    <dbReference type="GeneID" id="3374097"/>
    <dbReference type="KEGG" id="cpv:cgd3_2980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2980"/>
    <dbReference type="InParanoid" id="Q5CUF9"/>
    <dbReference type="OMA" id="IMRSASH"/>
    <dbReference type="OrthoDB" id="341486at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16691">
        <property type="entry name" value="mRING-H2-C3H3C2_Mio"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037593">
        <property type="entry name" value="MIOS/Sea4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453:SF9">
        <property type="entry name" value="GATOR COMPLEX PROTEIN MIOS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16453">
        <property type="entry name" value="WD40 DOMAIN-CONTAINING PROTEIN MIO FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="2">
        <location>
            <begin position="1104"/>
            <end position="1190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89033.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1198" mass="139434" checksum="6E68CF25721C805C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUH0</accession>
    <name>Q5CUH0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2860</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626844.1">
        <property type="nucleotide sequence ID" value="XM_626844.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUH0"/>
    <dbReference type="GeneID" id="3374106"/>
    <dbReference type="KEGG" id="cpv:cgd3_2860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2860"/>
    <dbReference type="InParanoid" id="Q5CUH0"/>
    <dbReference type="OrthoDB" id="343952at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="639"/>
            <end position="666"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="645"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="656"/>
            <end position="666"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="666" mass="76144" checksum="CEFEC27B5490BE49" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUX9</accession>
    <name>Q5CUX9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Synaptobrevin like SNARE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1070</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89288.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626685.1">
        <property type="nucleotide sequence ID" value="XM_626685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUX9"/>
    <dbReference type="GeneID" id="3373842"/>
    <dbReference type="KEGG" id="cpv:cgd3_1070"/>
    <dbReference type="InParanoid" id="Q5CUX9"/>
    <dbReference type="OMA" id="VKNKFWW"/>
    <dbReference type="OrthoDB" id="10042941at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042855">
        <property type="entry name" value="V_SNARE_CC"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00957">
        <property type="entry name" value="Synaptobrevin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="45"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="V-SNARE coiled-coil homology" evidence="2">
        <location>
            <begin position="10"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00957"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89288.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="103" mass="11437" checksum="FDABA220247A0F5D" modified="2005-04-12" version="1" fragment="single">KLCNVLKGILQALDGQAEVLEDETESFLQDSIKVKNKFWWKNIKYTLILGCLVSLIFIIAFANLFNTIFGNGINLLNLLKSNSIASKSYSGSNNNNNNIVLAL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUY5</accession>
    <name>Q5CUY5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89172.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626679.1">
        <property type="nucleotide sequence ID" value="XM_626679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUY5"/>
    <dbReference type="GeneID" id="3374176"/>
    <dbReference type="KEGG" id="cpv:cgd3_1000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1000"/>
    <dbReference type="InParanoid" id="Q5CUY5"/>
    <dbReference type="OMA" id="QWENANC"/>
    <dbReference type="OrthoDB" id="339706at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="27"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="95"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="139"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89172.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="175" mass="20358" checksum="07812C0CC1384633" modified="2005-04-12" version="1">MFLNVLKLTPLGGGPAPLLKNQIVRQCYSLMFLNIFIAIWSISSILYSKFTNANFGSEISTYFFIVFLIGSVNSIFFSKLGSLRYCSDSEWSNRLILILIINLVQYGAILWGCWISYKVFMSRYLAGTKMYYYFIFSRWMYNTLFGMTAFFSFSVIYTSFIYSKLLVSLTHQRVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUZ6</accession>
    <name>Q5CUZ6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14">ADP-ribosylation factor</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd3_860</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="14">GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Golgi apparatus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 13">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89292.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626668.1">
        <property type="nucleotide sequence ID" value="XM_626668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUZ6"/>
    <dbReference type="STRING" id="353152.Q5CUZ6"/>
    <dbReference type="GeneID" id="3373810"/>
    <dbReference type="KEGG" id="cpv:cgd3_860"/>
    <dbReference type="InParanoid" id="Q5CUZ6"/>
    <dbReference type="OMA" id="HYYANTN"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd04150">
        <property type="entry name" value="Arf1_5_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003539">
        <property type="entry name" value="ADP-ribosylation factor 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045872">
        <property type="entry name" value="Arf1-5-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024156">
        <property type="entry name" value="Small_GTPase_ARF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11711">
        <property type="entry name" value="ADP RIBOSYLATION FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 14" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8 14" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9 11 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="10 14" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 14" id="KW-0519">Myristate</keyword>
    <keyword evidence="5 11 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7 14" id="KW-0653">Protein transport</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 14" id="KW-0813">Transport</keyword>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="30"/>
            <end position="37"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="37"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="54"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="76"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <begin position="132"/>
            <end position="135"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU369003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK89292.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="189" mass="21456" checksum="7DFA25CE7EF01C52" modified="2005-04-12" version="1" fragment="single">RVYTAEMGLALTKIWRNLFGKKDMRILMVGLDAAGKTTILYKLKLGEVVTTIPTIGFNVETVEYKNISFTVWDVGGQDKIRPLWRHYYSNTDGLIFVIDSNDRERINDARDELARMLGEDELRDAVLLVFANKQDLPNAMSATDITEKLQLSGIRNRNWFIQSTCATSGDGLYEGLDWLSRTLASRSNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV23</accession>
    <name>Q5CV23_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626641.1">
        <property type="nucleotide sequence ID" value="XM_626641.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV23"/>
    <dbReference type="GeneID" id="3373794"/>
    <dbReference type="KEGG" id="cpv:cgd3_560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_560"/>
    <dbReference type="InParanoid" id="Q5CV23"/>
    <dbReference type="OMA" id="CQINIIN"/>
    <dbReference type="OrthoDB" id="341661at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254981" description="Protein kinase domain-containing protein" evidence="2">
        <location>
            <begin position="32"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="36"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="550" mass="63086" checksum="30F1BFE7F5E0B3C6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV43</accession>
    <name>Q5CV43_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89225.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626621.1">
        <property type="nucleotide sequence ID" value="XM_626621.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV43"/>
    <dbReference type="GeneID" id="3373999"/>
    <dbReference type="KEGG" id="cpv:cgd3_360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_360"/>
    <dbReference type="InParanoid" id="Q5CV43"/>
    <dbReference type="OrthoDB" id="339475at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89225.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="130" mass="15050" checksum="5CC7D804771B7FD5" modified="2005-04-12" version="1">MDLLKSTIYGNIDQEFVIDNTLDTCCFQFETAQSTLSMGFEDDIYLRDSIQTLQDDPDHIEHTDHNFNLNWDEDSSFDQKKQKELKELTFELATDPSPNSEFLVRVTETLNSILQNEFKALDFQVSPSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV68</accession>
    <name>Q5CV68_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">Histone H4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd8_5230</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4 11">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the histone H4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627401.1">
        <property type="nucleotide sequence ID" value="XM_627401.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV68"/>
    <dbReference type="FunCoup" id="Q5CV68">
        <property type="interactions" value="239"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV68"/>
    <dbReference type="GeneID" id="3374223"/>
    <dbReference type="KEGG" id="cpv:cgd8_5230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5230"/>
    <dbReference type="InParanoid" id="Q5CV68"/>
    <dbReference type="OMA" id="QKEHING"/>
    <dbReference type="OrthoDB" id="10255923at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22912">
        <property type="entry name" value="HFD_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000007">
        <property type="entry name" value="Histone H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035425">
        <property type="entry name" value="CENP-T/H4_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001951">
        <property type="entry name" value="Histone_H4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019809">
        <property type="entry name" value="Histone_H4_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10484">
        <property type="entry name" value="HISTONE H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15511">
        <property type="entry name" value="CENP-T_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00623">
        <property type="entry name" value="HISTONEH4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00417">
        <property type="entry name" value="H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00047">
        <property type="entry name" value="HISTONE_H4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0007">Acetylation</keyword>
    <keyword evidence="5 11" id="KW-0158">Chromosome</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0488">Methylation</keyword>
    <keyword evidence="10 11" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="9 11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CENP-T/Histone H4 histone fold" evidence="13">
        <location>
            <begin position="36"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="12">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006564"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011538"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022481"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK89645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="103" mass="11310" checksum="44A4ED26C1E740B3" modified="2005-04-12" version="1">MSGRGKGGKGLGKGGAKRHRKVLRDNIQGITKPAIRRLARRGGVKRISALIYEEVRGVLKAFLETVIKDAVTYTEYARRKTVTAMDVVHALKRQGKTLYGFGG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVI8</accession>
    <name>Q5CVI8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein with signal peptide plus 12x transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89543.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627281.1">
        <property type="nucleotide sequence ID" value="XM_627281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVI8"/>
    <dbReference type="GeneID" id="3374258"/>
    <dbReference type="KEGG" id="cpv:cgd8_3890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3890"/>
    <dbReference type="InParanoid" id="Q5CVI8"/>
    <dbReference type="OMA" id="GCLTESI"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015179">
        <property type="term" value="F:L-amino acid transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="67"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="205"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="368"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="413"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="524"/>
            <end position="544"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="550"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="581"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="106"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="107"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89543.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="614" mass="69031" checksum="6C50A67D3E75AB12" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVS9</accession>
    <name>Q5CVS9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">ERV41 like membrane associated protein involved in vesicular transport with a transmembrane region near the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_2900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ERGIC family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89702.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627190.1">
        <property type="nucleotide sequence ID" value="XM_627190.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVS9"/>
    <dbReference type="STRING" id="353152.Q5CVS9"/>
    <dbReference type="GeneID" id="3374332"/>
    <dbReference type="KEGG" id="cpv:cgd8_2900"/>
    <dbReference type="InParanoid" id="Q5CVS9"/>
    <dbReference type="OMA" id="MHCIPTQ"/>
    <dbReference type="OrthoDB" id="270930at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030134">
        <property type="term" value="C:COPII-coated ER to Golgi transport vesicle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045888">
        <property type="entry name" value="Erv"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012936">
        <property type="entry name" value="Erv_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039542">
        <property type="entry name" value="Erv_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10984:SF25">
        <property type="entry name" value="ENDOPLASMIC RETICULUM-GOLGI INTERMEDIATE COMPARTMENT PROTEIN 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07970">
        <property type="entry name" value="COPIIcoated_ERV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13850">
        <property type="entry name" value="ERGIC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="365"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter N-terminal" evidence="8">
        <location>
            <begin position="16"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="domain" description="Endoplasmic reticulum vesicle transporter C-terminal" evidence="7">
        <location>
            <begin position="135"/>
            <end position="378"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF13850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89702.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="403" mass="46495" checksum="77B276F251783D31" modified="2005-04-12" version="1" fragment="single">LDYFQGKRKFSNQTKMKQFDAFSKPISEFRIKTAFGGYLTILSMIAMIILFYSELKYYLNITRKDEVTVDHLSSNRNINLRMQLEFPKLPCDILGVRIINLQENKEIYLPDGGIEFVKIGSNESNANSSSGCGPCYDASIINDLGAVNCCNTCKDIFNEYDKKGIKLPHVISFKQCDYDKSKRISNALSSNLNSEGCKIKVNGYIPKVKGKIEISHKRWVKYKEMTDLEIAESHLFNFSYKMNYLDFGEELPGIPNRWKNQEYIQSSRFEKLGYSQDLVFEDAYIDFDMHCIPTQYNTINNKSINSHQFSVRSQYKKVLVSLANGKFIPDTSIPGIHINYDFTPFLVKITESRRSFLSFITECCAIIGGIFAFSGMIDIFFFKFLSSVNKYRQKNNTSFIQNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVY6</accession>
    <name>Q5CVY6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="18">Brahma like protein with a HSA domain, SNF2 like helicase and a bromo domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd8_2300</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627133.1">
        <property type="nucleotide sequence ID" value="XM_627133.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVY6"/>
    <dbReference type="GeneID" id="3374456"/>
    <dbReference type="KEGG" id="cpv:cgd8_2300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2300"/>
    <dbReference type="InParanoid" id="Q5CVY6"/>
    <dbReference type="OMA" id="HNSYSCP"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10810:FF:000015">
        <property type="entry name" value="lymphoid-specific helicase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014978">
        <property type="entry name" value="Gln-Leu-Gln_QLQ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00951">
        <property type="entry name" value="QLQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 18" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="7" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HSA" evidence="17">
        <location>
            <begin position="465"/>
            <end position="538"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="15">
        <location>
            <begin position="757"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="16">
        <location>
            <begin position="1063"/>
            <end position="1250"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="14">
        <location>
            <begin position="1496"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="296"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="377"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="595"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="641"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1618"/>
            <end position="1673"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="514"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="302"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="332"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="387"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="599"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1628"/>
            <end position="1659"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1660"/>
            <end position="1673"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAK89425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1673" mass="190861" checksum="5436B0EC2E48D7B0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW29</accession>
    <name>Q5CW29_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">LisH domain at N + WD40 repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_1860</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89388.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627090.1">
        <property type="nucleotide sequence ID" value="XM_627090.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW29"/>
    <dbReference type="STRING" id="353152.Q5CW29"/>
    <dbReference type="GeneID" id="3374507"/>
    <dbReference type="KEGG" id="cpv:cgd8_1860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1860"/>
    <dbReference type="InParanoid" id="Q5CW29"/>
    <dbReference type="OMA" id="ECENTQA"/>
    <dbReference type="OrthoDB" id="1367865at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.960.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024977">
        <property type="entry name" value="Apc4-like_WD40_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045183">
        <property type="entry name" value="Ebi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006594">
        <property type="entry name" value="LisH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846:SF2">
        <property type="entry name" value="F-BOX-LIKE_WD REPEAT-CONTAINING PROTEIN EBI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22846">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12894">
        <property type="entry name" value="ANAPC4_WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08513">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00667">
        <property type="entry name" value="LisH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50896">
        <property type="entry name" value="LISH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="Anaphase-promoting complex subunit 4-like WD40" evidence="6">
        <location>
            <begin position="432"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="132"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="189"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="205"/>
            <end position="215"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="222"/>
            <end position="237"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF12894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89388.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="704" mass="77845" checksum="4272989154DB1079" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW59</accession>
    <name>Q5CW59_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ubiquitin carboxyl terminal hydrolase domain that is fused to a MATH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_1530</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627060.1">
        <property type="nucleotide sequence ID" value="XM_627060.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW59"/>
    <dbReference type="GeneID" id="3374473"/>
    <dbReference type="KEGG" id="cpv:cgd8_1530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1530"/>
    <dbReference type="InParanoid" id="Q5CW59"/>
    <dbReference type="OMA" id="DISHNTR"/>
    <dbReference type="OrthoDB" id="289038at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031647">
        <property type="term" value="P:regulation of protein stability"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02659">
        <property type="entry name" value="peptidase_C19C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050164">
        <property type="entry name" value="Peptidase_C19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001394">
        <property type="entry name" value="Peptidase_C19_UCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028889">
        <property type="entry name" value="USP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018200">
        <property type="entry name" value="USP_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24006:SF644">
        <property type="entry name" value="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00443">
        <property type="entry name" value="UCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00972">
        <property type="entry name" value="USP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50235">
        <property type="entry name" value="USP_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="1">
        <location>
            <begin position="32"/>
            <end position="196"/>
        </location>
    </feature>
    <feature type="domain" description="USP" evidence="2">
        <location>
            <begin position="226"/>
            <end position="677"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1607" mass="181321" checksum="29D9654773809C1F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW80</accession>
    <name>Q5CW80_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Calpain like thiol protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_1320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89347.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627039.1">
        <property type="nucleotide sequence ID" value="XM_627039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW80"/>
    <dbReference type="STRING" id="353152.Q5CW80"/>
    <dbReference type="GeneID" id="3374269"/>
    <dbReference type="KEGG" id="cpv:cgd8_1320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1320"/>
    <dbReference type="InParanoid" id="Q5CW80"/>
    <dbReference type="OMA" id="LWNISEY"/>
    <dbReference type="OrthoDB" id="167576at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004198">
        <property type="term" value="F:calcium-dependent cysteine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051297">
        <property type="entry name" value="PalB/RIM13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001300">
        <property type="entry name" value="Peptidase_C2_calpain_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46143:SF1">
        <property type="entry name" value="CALPAIN-7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00648">
        <property type="entry name" value="Peptidase_C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00230">
        <property type="entry name" value="CysPc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50203">
        <property type="entry name" value="CALPAIN_CAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 4 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0788">Thiol protease</keyword>
    <feature type="domain" description="Calpain catalytic" evidence="5">
        <location>
            <begin position="132"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="178"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="417"/>
        </location>
    </feature>
    <feature type="active site" evidence="4">
        <location>
            <position position="443"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022807"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89347.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="903" mass="107370" checksum="9B62C60E060EFE4B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWA3</accession>
    <name>Q5CWA3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89331.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627016.1">
        <property type="nucleotide sequence ID" value="XM_627016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWA3"/>
    <dbReference type="GeneID" id="3374563"/>
    <dbReference type="KEGG" id="cpv:cgd8_1090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1090"/>
    <dbReference type="InParanoid" id="Q5CWA3"/>
    <dbReference type="OMA" id="DKVNNQD"/>
    <dbReference type="OrthoDB" id="343040at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="21"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="186"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="254"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="44"/>
            <end position="57"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="280"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="299"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89331.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="364" mass="40583" checksum="8D26816482426CDA" modified="2005-04-12" version="1">MGRKSSDGSGMGADILHALGFNKTSNSDNSDTADNKSKGQTKLGRLKFPKNKKKSKKHNIEVDSAKFSTEIDLKANDNSEIEQASEKPTNSSLMDVQLSFEGVLTELEKSLENIKKNVDHAESCLENIYISVDKLEKFSELCKVENKDVILGLHKLVNVHKGAALLSTFSSDPTFKKNCDYNVSDESKSAEKRLESKRSGDTNVVESEHESNVATVIETHNSNNSETKPAFVKSNSKTYNVKNSLSNNVFNKTEMVTPSKSNNNFNSESPSAKSTMKSEPINKELEITKDVNASYSDKNNSEKSPKEGKISKTEKFKEKLNLKMRKKKDSTHESNDPDSADAENSTGIQTRMERFKKKFDRKSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWC9</accession>
    <name>Q5CWC9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">AP2/ERF domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626990.1">
        <property type="nucleotide sequence ID" value="XM_626990.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWC9"/>
    <dbReference type="GeneID" id="3374525"/>
    <dbReference type="KEGG" id="cpv:cgd8_810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_810"/>
    <dbReference type="InParanoid" id="Q5CWC9"/>
    <dbReference type="OMA" id="WVANDNT"/>
    <dbReference type="OrthoDB" id="366289at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003700">
        <property type="term" value="F:DNA-binding transcription factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001471">
        <property type="entry name" value="AP2/ERF_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00847">
        <property type="entry name" value="AP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AP2/ERF" evidence="7">
        <location>
            <begin position="589"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="495"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="694"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1059"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1174"/>
            <end position="1200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="1240"/>
            <end position="1326"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="13"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="515"/>
            <end position="528"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="536"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1061"/>
            <end position="1091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="1174"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="1248"/>
            <end position="1262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="1275"/>
            <end position="1293"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1342" mass="141383" checksum="402D6EE245CEF2E1" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWM5</accession>
    <name>Q5CWM5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ankyrin repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_4480</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627779.1">
        <property type="nucleotide sequence ID" value="XM_627779.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWM5"/>
    <dbReference type="STRING" id="353152.Q5CWM5"/>
    <dbReference type="GeneID" id="3375912"/>
    <dbReference type="KEGG" id="cpv:cgd6_4480"/>
    <dbReference type="InParanoid" id="Q5CWM5"/>
    <dbReference type="OMA" id="LPHTCAP"/>
    <dbReference type="OrthoDB" id="285735at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1440">
        <property type="entry name" value="PHAX RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019385">
        <property type="entry name" value="PHAX_RNA-binding_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038092">
        <property type="entry name" value="PHAX_RNA-binding_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171:SF9">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24171">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 39-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10258">
        <property type="entry name" value="PHAX_RNA-bd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01415">
        <property type="entry name" value="ANKYRIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="217"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="260"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="293"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="326"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphorylated adapter RNA export protein RNA-binding" evidence="4">
        <location>
            <begin position="406"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF10258"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="508" mass="57232" checksum="512B661779956D0A" modified="2005-04-12" version="1" fragment="single">VLIELNPKVRTKMMEIAKYRGTRDSIKIESPKEKLEIKSGEYIGSIDGEFDELNHEIYEFIHQCLNTDDSDLLFPTFEEQLQSTCISNGSETVKTGGTYMDVNPLQGDRESFRFGFENENNSQYMNIKQECMNTASNNVGGFSMSLENTFDFNGILLKASFLGKTDIIKSCLDNGANVLHTDKVGRTALHYASACGWLPTMKLLLKYNCDINRRDHKNWTALHIGVSKKFPEVVELLLSSGADLSLGLPHTCAPCRGGPISSKAIHFAAIRGNRMITEILLKYGADINDVDEDNKTPLHYASFRSNLDYAKWVIEKGADVNAKDKYGRTPLHIASLSGNLEITKILIENGSEVRARDIWDMSPLSLALTREHPEMVSYLESISGEKSSEISVIRGFELDTMESIVLNTIVTGLQEPKKEFIARVIKTIGSQRSLQLYENAMKVENSGGLLTADMSRRKTIGGVFCYLLKQLVAEDQITIQEWNYIRQEEKERINAKNILKRNNRRCQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWN6</accession>
    <name>Q5CWN6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RRM domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_4370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90034.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627768.1">
        <property type="nucleotide sequence ID" value="XM_627768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWN6"/>
    <dbReference type="STRING" id="353152.Q5CWN6"/>
    <dbReference type="GeneID" id="3375779"/>
    <dbReference type="KEGG" id="cpv:cgd6_4370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4370"/>
    <dbReference type="InParanoid" id="Q5CWN6"/>
    <dbReference type="OMA" id="GFCEYQS"/>
    <dbReference type="OrthoDB" id="6275295at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12446">
        <property type="entry name" value="RRM_RBM25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052768">
        <property type="entry name" value="RBM25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034268">
        <property type="entry name" value="RBM25_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806">
        <property type="entry name" value="RBM25 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18806:SF4">
        <property type="entry name" value="RNA-BINDING PROTEIN 25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="63"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="197"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="251"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90034.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="556" mass="63349" checksum="2CE5CFA37F604115" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWP2</accession>
    <name>Q5CWP2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_4300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627762.1">
        <property type="nucleotide sequence ID" value="XM_627762.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWP2"/>
    <dbReference type="STRING" id="353152.Q5CWP2"/>
    <dbReference type="GeneID" id="3375774"/>
    <dbReference type="KEGG" id="cpv:cgd6_4300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4300"/>
    <dbReference type="InParanoid" id="Q5CWP2"/>
    <dbReference type="OMA" id="QITIESY"/>
    <dbReference type="OrthoDB" id="440020at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="431"/>
            <end position="497"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="502"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="593"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="438"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="470"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="480"/>
            <end position="497"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="724" mass="82541" checksum="84DC9471B2BB0E3D" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWU5</accession>
    <name>Q5CWU5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_3680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90154.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627709.1">
        <property type="nucleotide sequence ID" value="XM_627709.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWU5"/>
    <dbReference type="GeneID" id="3375899"/>
    <dbReference type="KEGG" id="cpv:cgd6_3680"/>
    <dbReference type="InParanoid" id="Q5CWU5"/>
    <dbReference type="OMA" id="NKEEYRT"/>
    <dbReference type="OrthoDB" id="343457at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="372"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="541"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="161"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="221"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="375"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="388"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90154.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="579" mass="65812" checksum="51709F56D1A5AB32" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX20</accession>
    <name>Q5CX20_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_2860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89918.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627634.1">
        <property type="nucleotide sequence ID" value="XM_627634.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX20"/>
    <dbReference type="GeneID" id="3376158"/>
    <dbReference type="KEGG" id="cpv:cgd6_2860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2860"/>
    <dbReference type="InParanoid" id="Q5CX20"/>
    <dbReference type="OMA" id="IHNEEMN"/>
    <dbReference type="OrthoDB" id="341736at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="624"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="280"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="512"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="624"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="648"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89918.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="697" mass="82359" checksum="37BA70E62809EFB6" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX46</accession>
    <name>Q5CX46_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_2550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the Luc7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627608.1">
        <property type="nucleotide sequence ID" value="XM_627608.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX46"/>
    <dbReference type="FunCoup" id="Q5CX46">
        <property type="interactions" value="453"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX46"/>
    <dbReference type="GeneID" id="3375885"/>
    <dbReference type="KEGG" id="cpv:cgd6_2550"/>
    <dbReference type="InParanoid" id="Q5CX46"/>
    <dbReference type="OMA" id="PCTRIHD"/>
    <dbReference type="OrthoDB" id="153872at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004882">
        <property type="entry name" value="Luc7-rel"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12375">
        <property type="entry name" value="RNA-BINDING PROTEIN LUC7-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03194">
        <property type="entry name" value="LUC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="276"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="341"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="362"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005655"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="380" mass="44650" checksum="37746EC9471AFB74" modified="2005-04-12" version="1" fragment="single">YIPIIMDEIRRQIEDLMGGIEAPIEKKNPHDNDVCKFYLCGLCPHELFENTKLYMGPCKNIHSEVLREKYLSERESKGNTRIKYETDSLRVFQGMVDDCNKKIERNRVRAELSGSSKLEDENIRALDLEIKEIMKEIDDLGANGDIDGSLKRMEDLTRLNQQKMKISATKEDVENGMYRQKLHPCEICAAFLSETDNDQRLNDHFNGKIHVGYLKIRKQAKDLKEWIKAHSPNRDSNYRHENIAHKGDFRYKSHRQSYSGEGRAYYYSNNYRDRRNREHMDYRDNYGNHSSRRENNQTRYEELGNNYKSTVQSDYNSFGPRNKHINTRSNPYSTVELNRISSEKHKKHIKEDTKIYPPSDGEISPESDSSRSLSRSISPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX48</accession>
    <name>Q5CX48_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ion transport domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_2520</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89895.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627606.1">
        <property type="nucleotide sequence ID" value="XM_627606.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX48"/>
    <dbReference type="STRING" id="353152.Q5CX48"/>
    <dbReference type="GeneID" id="3376135"/>
    <dbReference type="KEGG" id="cpv:cgd6_2520"/>
    <dbReference type="InParanoid" id="Q5CX48"/>
    <dbReference type="OrthoDB" id="343823at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.350">
        <property type="entry name" value="Voltage-gated potassium channels. Chain C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027359">
        <property type="entry name" value="Volt_channel_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483">
        <property type="entry name" value="CHROMOSOME 1, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38483:SF1">
        <property type="entry name" value="ION TRANSPORT DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="83"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="117"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89895.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="155" mass="18024" checksum="789B1ADCDB1DCC90" modified="2007-04-03" version="1">MDMYRYPGGLTSTDFHNFEINGSSRDQGFSFWASNLTCEERAITIVKRLYYSEFSKYLYLGIFLLNILVLFSGLFRAQSGSRFSIFLETIITLTLTFEVIIKLFLMKKRFFNKVNNVFDFVVALTCLSLLFLNGDIRRLFATKKIADLRNNQIVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX55</accession>
    <name>Q5CX55_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89890.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627599.1">
        <property type="nucleotide sequence ID" value="XM_627599.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX55"/>
    <dbReference type="GeneID" id="3376130"/>
    <dbReference type="KEGG" id="cpv:cgd6_2440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2440"/>
    <dbReference type="InParanoid" id="Q5CX55"/>
    <dbReference type="OMA" id="GINWRNG"/>
    <dbReference type="OrthoDB" id="338963at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="28"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="98"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="131"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89890.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="263" mass="30698" checksum="C8E5497AD81A0D10" modified="2007-04-03" version="1">MEEKKTVKNKVRIVEGEKKVTSNAKLRLVYDALSVTYFSVLWMMMFLDCGPNYFSFFYYLTNWGCTSTLIFYFIATLVDYERLVKVNVSTRLIHSCTFVRELSISLQSVIVPFFWIIVYPKEKWRSITWEVQMHGMGLIFICIDYLIRTSNFSSLSSKNLFMVVLSYLTLNYFVVNKLETMIYPGITYNTVESWIVVTLAIALVLIAHQLASIITICLVVKNKIWRKYEKDDFVSKSIKIVQKAQKLRHKDGVRKRLGSIFVG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXA2</accession>
    <name>Q5CXA2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Bcp1p/BRCA and CDKN1A-interacting protein isoform C-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_1880</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89853.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627552.1">
        <property type="nucleotide sequence ID" value="XM_627552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXA2"/>
    <dbReference type="STRING" id="353152.Q5CXA2"/>
    <dbReference type="GeneID" id="3376065"/>
    <dbReference type="KEGG" id="cpv:cgd6_1880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1880"/>
    <dbReference type="InParanoid" id="Q5CXA2"/>
    <dbReference type="OMA" id="NFTHILG"/>
    <dbReference type="OrthoDB" id="27543at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025602">
        <property type="entry name" value="BCP1_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261">
        <property type="entry name" value="BRCA2 AND CDKN1A INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13261:SF0">
        <property type="entry name" value="BRCA2 AND CDKN1A-INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13862">
        <property type="entry name" value="BCCIP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="34"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="62"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89853.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="284" mass="33016" checksum="B23B0A5FDE11413A" modified="2007-04-03" version="1">MSSKKHIRVDDESNQLNFNNESIDGEIFLSATESPSYGKKAKRTDSDSSDNESVIDGEFEFNDPNENDYHSIKNILLMSQYSRIKGIQFHEFVDLICNQGNIGTTVSISDSIIAFSTILNFRQYKETLNKIVDYLSGVISKSRNKEFENLFNSVIYEKNVGLMVNERFPNTPLEIVPALCNCLKDDIQWTIDNLYTDIPNKEREYYKWDYIILLTTRYISPDSNTIIYQKYEEEKLVINSLHTIIWQGDKKQLCGTGKKDETDLMNQQFLVSILSYDQFQKNYN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXJ2</accession>
    <name>Q5CXJ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Gdb1p glycogen debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_880</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89776.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627462.1">
        <property type="nucleotide sequence ID" value="XM_627462.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXJ2"/>
    <dbReference type="GeneID" id="3376086"/>
    <dbReference type="KEGG" id="cpv:cgd6_880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_880"/>
    <dbReference type="InParanoid" id="Q5CXJ2"/>
    <dbReference type="OMA" id="YEEGHVH"/>
    <dbReference type="OrthoDB" id="10248904at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004134">
        <property type="term" value="F:4-alpha-glucanotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004135">
        <property type="term" value="F:amylo-alpha-1,6-glucosidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005980">
        <property type="term" value="P:glycogen catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02859">
        <property type="entry name" value="E_set_AMPKbeta_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008928">
        <property type="entry name" value="6-hairpin_glycosidase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010401">
        <property type="entry name" value="AGL/Gdb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032788">
        <property type="entry name" value="AGL_central"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032792">
        <property type="entry name" value="AGL_glucanoTrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032640">
        <property type="entry name" value="AMPK1_CBM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032790">
        <property type="entry name" value="GDE_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10569:SF2">
        <property type="entry name" value="GLYCOGEN DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16561">
        <property type="entry name" value="AMPK1_CBM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06202">
        <property type="entry name" value="GDE_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14701">
        <property type="entry name" value="hDGE_amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14702">
        <property type="entry name" value="hGDE_central"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48208">
        <property type="entry name" value="Six-hairpin glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycogen debranching enzyme glucanotransferase" evidence="3">
        <location>
            <begin position="222"/>
            <end position="673"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-activated protein kinase glycogen-binding" evidence="5">
        <location>
            <begin position="952"/>
            <end position="1002"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme central" evidence="4">
        <location>
            <begin position="1021"/>
            <end position="1281"/>
        </location>
    </feature>
    <feature type="domain" description="Glycogen debranching enzyme C-terminal" evidence="2">
        <location>
            <begin position="1405"/>
            <end position="1881"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF06202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF14701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF14702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89776.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1891" mass="217678" checksum="C42A28D027F17D2B" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXP9</accession>
    <name>Q5CXP9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">CtIP type zinc knuckle (C2H2)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_5380</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628681.1">
        <property type="nucleotide sequence ID" value="XM_628679.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXP9"/>
    <dbReference type="STRING" id="353152.Q5CXP9"/>
    <dbReference type="GeneID" id="3372149"/>
    <dbReference type="KEGG" id="cpv:cgd7_5380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5380"/>
    <dbReference type="InParanoid" id="Q5CXP9"/>
    <dbReference type="OMA" id="AYECVEC"/>
    <dbReference type="OrthoDB" id="5801062at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010792">
        <property type="term" value="P:DNA double-strand break processing involved in repair via single-strand annealing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013882">
        <property type="entry name" value="Ctp1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033316">
        <property type="entry name" value="RBBP8-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107:SF0">
        <property type="entry name" value="DNA ENDONUCLEASE ACTIVATOR CTP1 C-TERMINAL DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15107">
        <property type="entry name" value="RETINOBLASTOMA BINDING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08573">
        <property type="entry name" value="SAE2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA endonuclease activator Ctp1 C-terminal" evidence="6">
        <location>
            <begin position="189"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="243"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="27"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="266" mass="30808" checksum="106E26D02C907614" modified="2005-04-12" version="1">MDQIIDDDEYNSIFPLEKIASHLNISLKFLENAQIQWMNEKESLLREIERLRMENRTLRMEVRSSENIERNSVSNTPNNNRIKSYYLINNDSGQIIPIPPNPVNQVVGRSCSSSNNIKRVNDVLEIQNITERNSNAIPNRNSISASRSIQNDQISPATSSQNCRVRHIQLEDENSDHEPLEEKKKAIKYREVGKSIGKKEQRKNLEAFECTECSKFYKAINNNRTSNSQSMCKHLKQSLLLQNSGRHRFKHPPTKSPPGYWDLDEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXX7</accession>
    <name>Q5CXX7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal peptide, large secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90428.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628603.1">
        <property type="nucleotide sequence ID" value="XM_628601.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXX7"/>
    <dbReference type="GeneID" id="3372182"/>
    <dbReference type="KEGG" id="cpv:cgd7_4530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4530"/>
    <dbReference type="InParanoid" id="Q5CXX7"/>
    <dbReference type="OMA" id="GHIIRTH"/>
    <dbReference type="OrthoDB" id="337828at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90428.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1891" mass="221636" checksum="E2A3F090E009BE95" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY26</accession>
    <name>Q5CY26_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3930</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628554.1">
        <property type="nucleotide sequence ID" value="XM_628552.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY26"/>
    <dbReference type="GeneID" id="3372140"/>
    <dbReference type="KEGG" id="cpv:cgd7_3930"/>
    <dbReference type="InParanoid" id="Q5CY26"/>
    <dbReference type="OMA" id="RICTGEC"/>
    <dbReference type="OrthoDB" id="412647at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008641">
        <property type="term" value="F:ubiquitin-like modifier activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="208" mass="23606" checksum="0D5319EF41D0B095" modified="2005-04-12" version="1">MNPLTKVYTADQDETDVELFCESCLNKTNYTGIVASLDEEVNMLNAKNISKKFQSKDTFISFSVSIGTRIFLFFNNNTITFDEALEFNIDKLKQILHSVKNLHPYILIIICMLRERYQKAVKNESQSSEIDEILKEIKTTPSIDIEKALELEKIFNETWGKTISPIASIGGGLLCQEVTKFCIHGVGEYFCCIFDMELCEAVTATVKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY53</accession>
    <name>Q5CY53_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ATP-dependent (S)-NAD(P)H-hydrate dehydratase</fullName>
            <ecNumber evidence="6">4.2.1.93</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">ATP-dependent NAD(P)HX dehydratase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_3640</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-NADHX + ATP = ADP + phosphate + NADH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19017"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:64074"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>(6S)-NADPHX + ATP = ADP + phosphate + NADPH + H(+)</text>
            <dbReference type="Rhea" id="RHEA:32231"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="4.2.1.93"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="6">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the NnrD/CARKD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.93" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628527.1">
        <property type="nucleotide sequence ID" value="XM_628525.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY53"/>
    <dbReference type="FunCoup" id="Q5CY53">
        <property type="interactions" value="79"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY53"/>
    <dbReference type="GeneID" id="3372114"/>
    <dbReference type="KEGG" id="cpv:cgd7_3640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3640"/>
    <dbReference type="InParanoid" id="Q5CY53"/>
    <dbReference type="OMA" id="CERTPNI"/>
    <dbReference type="OrthoDB" id="8110916at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047453">
        <property type="term" value="F:ATP-dependent NAD(P)H-hydrate dehydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0110051">
        <property type="term" value="P:metabolite repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046496">
        <property type="term" value="P:nicotinamide nucleotide metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01171">
        <property type="entry name" value="YXKO-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1190.20">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01965">
        <property type="entry name" value="NADHX_dehydratase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017953">
        <property type="entry name" value="Carbohydrate_kinase_pred_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000631">
        <property type="entry name" value="CARKD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029056">
        <property type="entry name" value="Ribokinase-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592:SF0">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12592">
        <property type="entry name" value="ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01256">
        <property type="entry name" value="Carb_kinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53613">
        <property type="entry name" value="Ribokinase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01050">
        <property type="entry name" value="YJEF_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51383">
        <property type="entry name" value="YJEF_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 6" id="KW-0456">Lyase</keyword>
    <keyword evidence="4 6" id="KW-0520">NAD</keyword>
    <keyword evidence="3" id="KW-0521">NADP</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="YjeF C-terminal" evidence="8">
        <location>
            <begin position="55"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="232"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="236"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="165"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="218"/>
            <end position="224"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="415"/>
            <end position="419"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="434"/>
            <end position="443"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="444"/>
        </location>
        <ligand>
            <name>(6S)-NADPHX</name>
            <dbReference type="ChEBI" id="CHEBI:64076"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51383"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="545" mass="60702" checksum="684928CA33350F1F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY62</accession>
    <name>Q5CY62_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Cgd7_3550 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_3550</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the LTV1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628518.1">
        <property type="nucleotide sequence ID" value="XM_628516.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY62"/>
    <dbReference type="STRING" id="353152.Q5CY62"/>
    <dbReference type="GeneID" id="3372106"/>
    <dbReference type="KEGG" id="cpv:cgd7_3550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3550"/>
    <dbReference type="InParanoid" id="Q5CY62"/>
    <dbReference type="OMA" id="ERRWDCE"/>
    <dbReference type="OrthoDB" id="5852896at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000056">
        <property type="term" value="P:ribosomal small subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007307">
        <property type="entry name" value="Ltv1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531">
        <property type="entry name" value="LOW-TEMPERATURE VIABILITY PROTEIN LTV1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21531:SF0">
        <property type="entry name" value="PROTEIN LTV1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="418"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="236"/>
            <end position="263"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="420"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="439"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="482" mass="55715" checksum="DD98D89018326DF4" modified="2005-04-12" version="1">MGKRNNKNVVKLRLLSSANGVDGSSPRWAPVSNREFTHDEKQGIRKIIGNVYFHDELNDINFELKNLESKTSVQKNKINNDFNTDVFKDNYFPDDGYDYEQHLCTIKKDGNYMNSTLKHKTNLDPKSLLFNSTSILSNSEIEIHKGDFLSELVELVNCLEEPDDFEELNDDFILDMTGLKNKCELDKNIDMNDILWGGGKLNSSLKDDIQRLNSEFNQSELITQNFDSSSVFSEENYNNENDNDSLENLLNEYNDNIAVLDEDTNESSLIEFNKKLDVSEYEHILDRYINQVKIRNSAKSKPEKSYGEIGMPLDKAQVEKIISILESTEIYDNSSEATLSDISDFESIEKISESFSQASFEVINKPKKVDILSYYSSLNSKGQTNCPTPTRQNFFFENEEYSHNQHNNLRAPIVASLPLRKKDETPEDRRNRKQAVKQAKREMRDLKRKNKQDTKNIKKSVVRNLINSNNNDIKSGVRYFRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYA0</accession>
    <name>Q5CYA0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryote specific membrane proteins signal peptide plus 8 transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_3150</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the LIMR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628480.1">
        <property type="nucleotide sequence ID" value="XM_628478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYA0"/>
    <dbReference type="STRING" id="353152.Q5CYA0"/>
    <dbReference type="GeneID" id="3372295"/>
    <dbReference type="KEGG" id="cpv:cgd7_3150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3150"/>
    <dbReference type="InParanoid" id="Q5CYA0"/>
    <dbReference type="OMA" id="IYNQCIH"/>
    <dbReference type="OrthoDB" id="203099at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051584">
        <property type="entry name" value="GPCR-associated_LMBR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006876">
        <property type="entry name" value="LMBR1-like_membr_prot"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21355:SF0">
        <property type="entry name" value="G-PROTEIN COUPLED RECEPTOR-ASSOCIATED PROTEIN LMBRD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04791">
        <property type="entry name" value="LMBR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="6"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="34"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="74"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="147"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="410"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="459"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="501"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="550"/>
            <end position="568"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="637" mass="74583" checksum="04DC0BA6A61C22BB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYB6</accession>
    <name>Q5CYB6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Dynactin subunit 6</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_2970</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628464.1">
        <property type="nucleotide sequence ID" value="XM_628462.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYB6"/>
    <dbReference type="STRING" id="353152.Q5CYB6"/>
    <dbReference type="GeneID" id="3372280"/>
    <dbReference type="KEGG" id="cpv:cgd7_2970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2970"/>
    <dbReference type="InParanoid" id="Q5CYB6"/>
    <dbReference type="OMA" id="IFEIRSH"/>
    <dbReference type="OrthoDB" id="2355at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005869">
        <property type="term" value="C:dynactin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070840">
        <property type="term" value="F:dynein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007052">
        <property type="term" value="P:mitotic spindle organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027777">
        <property type="entry name" value="DCTN6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011004">
        <property type="entry name" value="Trimer_LpxA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072">
        <property type="entry name" value="DYNACTIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13072:SF0">
        <property type="entry name" value="DYNACTIN SUBUNIT 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51161">
        <property type="entry name" value="Trimeric LpxA-like enzymes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00016573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="166" mass="18051" checksum="430A68C10ECBFCCD" modified="2005-04-12" version="1">MQENKNLASLICQESNISGNVELDEGCIVHPSALIDGGVGGIIIGKNNIIEESVKIVNKTINKMPIGNNNWFHVRCEVDSALSIGDNNSFEVGSRVNKNVKIGNNCIISLKSSLPPNLEICNDMCVSQVGDSLLYAPINSSPNKHLCEQVNFLNNILRGSSMEKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYQ6</accession>
    <name>Q5CYQ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_1400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90196.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628324.1">
        <property type="nucleotide sequence ID" value="XM_628322.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYQ6"/>
    <dbReference type="GeneID" id="3372242"/>
    <dbReference type="KEGG" id="cpv:cgd7_1400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1400"/>
    <dbReference type="InParanoid" id="Q5CYQ6"/>
    <dbReference type="OMA" id="LTETNIY"/>
    <dbReference type="OrthoDB" id="341232at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254395" evidence="2">
        <location>
            <begin position="26"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="47"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90196.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="730" mass="79115" checksum="687F1534263C7F53" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYQ8</accession>
    <name>Q5CYQ8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SbmA/BacA-like family protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_1380</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90193.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628322.1">
        <property type="nucleotide sequence ID" value="XM_628320.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYQ8"/>
    <dbReference type="GeneID" id="3372239"/>
    <dbReference type="KEGG" id="cpv:cgd7_1380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1380"/>
    <dbReference type="InParanoid" id="Q5CYQ8"/>
    <dbReference type="OMA" id="IMEIRNN"/>
    <dbReference type="OrthoDB" id="339483at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009248">
        <property type="entry name" value="SbmA_BacA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05992">
        <property type="entry name" value="SbmA_BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2 4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="72"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="173"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90193.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="338" mass="39341" checksum="37F41066EB54E197" modified="2005-04-12" version="1">MIRKFLFSSRYSASTWFYCFLLIILNVQYSKLHLKVTKWFSEIYNLLVSSFNSKPGESYEDEIREKMLNLPLFLIFLCVFRVLSNFFLTVILLNWRNYESKYLFDNWRFIKGVEGVSQRIQEDTLQVLKLILNLFFKVVISISRSLVHIPILIEHSRKVSGIPPFPSGFEYSLISYLAISISVSILGVYFTSRKMSSKIMRKEIVEAEFRKQLILGEEGIPRLNLSLIEDTLVDELKLIHSDIYLYSFRYSLISESLGSLVGFLPTILLIPAIVRKDITIGGRATIIRCFNTVTSGITCFFFNWDDISELYTAIKRLYNLEQRINKCKLEPSTLLNEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYR5</accession>
    <name>Q5CYR5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_1300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628315.1">
        <property type="nucleotide sequence ID" value="XM_628313.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372258"/>
    <dbReference type="KEGG" id="cpv:cgd7_1300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1300"/>
    <dbReference type="InParanoid" id="Q5CYR5"/>
    <dbReference type="OMA" id="CFINNIS"/>
    <dbReference type="OrthoDB" id="343331at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254668" evidence="2">
        <location>
            <begin position="28"/>
            <end position="1483"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="148"/>
            <end position="192"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="148"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="158"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1483" mass="171002" checksum="A6FB5B5981E6CB76" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="133" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ29</accession>
    <name>Q5CZ29_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd7_40</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="20" key="2">
        <citation type="submission" date="2009-05" db="PDB data bank">
            <title>Crystal structure of a cdpk kinase domain from cryptosporidium Parvum, cgd7_40.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Hutchinson A."/>
                <person name="Wasney G."/>
                <person name="Vedadi M."/>
                <person name="MacKenzie F."/>
                <person name="Kozieradzki I."/>
                <person name="Cossar D."/>
                <person name="Weigelt J."/>
                <person name="Edwards A.M."/>
                <person name="Arrowsmith C.H."/>
                <person name="Bountra C."/>
                <person name="Botchkarev A."/>
                <person name="Hui R."/>
                <person name="Amani M."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 126-452 IN COMPLEX WITH MG(2+) AND ZN(2+)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90662.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628201.1">
        <property type="nucleotide sequence ID" value="XM_628199.1"/>
    </dbReference>
    <dbReference type="PDB" id="3HKO">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A=126-452"/>
    </dbReference>
    <dbReference type="PDBsum" id="3HKO"/>
    <dbReference type="AlphaFoldDB" id="Q5CZ29"/>
    <dbReference type="SMR" id="Q5CZ29"/>
    <dbReference type="STRING" id="353152.Q5CZ29"/>
    <dbReference type="BindingDB" id="Q5CZ29"/>
    <dbReference type="ChEMBL" id="CHEMBL4295845"/>
    <dbReference type="GeneID" id="3371759"/>
    <dbReference type="KEGG" id="cpv:cgd7_40"/>
    <dbReference type="InParanoid" id="Q5CZ29"/>
    <dbReference type="OMA" id="TVIARYC"/>
    <dbReference type="OrthoDB" id="336747at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CZ29"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="20" id="KW-0002">3D-structure</keyword>
    <keyword evidence="10 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9" id="KW-0106">Calcium</keyword>
    <keyword evidence="8 18" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 20" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <keyword evidence="20" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Protein kinase" evidence="16">
        <location>
            <begin position="135"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="550"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="17">
        <location>
            <begin position="586"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="64"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="761"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="768"/>
            <end position="783"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="164"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="218"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="247"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="249"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="252"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="320"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="18">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAK90662.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="3HKO"/>
        </source>
    </evidence>
    <sequence length="824" mass="93030" checksum="7540800AED1FDCF1" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPM1</accession>
    <name>A3FPM1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Cyclin-dependent kinase 2 homolog</fullName>
            <ecNumber evidence="1">2.7.11.23</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Cell division control protein 2 homolog</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">cdc2-related kinase 2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd7_430</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.23" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51560.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388367.1">
        <property type="nucleotide sequence ID" value="XM_001388330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPM1"/>
    <dbReference type="FunCoup" id="A3FPM1">
        <property type="interactions" value="38"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPM1"/>
    <dbReference type="GeneID" id="3371866"/>
    <dbReference type="KEGG" id="cpv:cgd7_430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_430"/>
    <dbReference type="InParanoid" id="A3FPM1"/>
    <dbReference type="OMA" id="GIHHCHR"/>
    <dbReference type="OrthoDB" id="1732493at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070985">
        <property type="term" value="C:transcription factor TFIIK complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004713">
        <property type="term" value="F:protein tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008353">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007346">
        <property type="term" value="P:regulation of mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07841">
        <property type="entry name" value="STKc_CDK7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050108">
        <property type="entry name" value="CDK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037770">
        <property type="entry name" value="CDK7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020635">
        <property type="entry name" value="Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056">
        <property type="entry name" value="CELL DIVISION PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24056:SF107">
        <property type="entry name" value="CYCLIN-DEPENDENT KINASE 11A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00219">
        <property type="entry name" value="TyrKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 13 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6 16" id="KW-0418">Kinase</keyword>
    <keyword evidence="5 13 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="15">
        <location>
            <begin position="9"/>
            <end position="301"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="12">
        <location>
            <position position="142"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <begin position="15"/>
            <end position="23"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="38"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="39"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00038543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00039612"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00041902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR637770-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAZ51560.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="320" mass="36735" checksum="6905BD8849FB50FB" modified="2007-04-03" version="1">MFSISERYEQINAHIGQGTYGKVEKAIDKNSDTIVAIKKVKICELPSDLTESRQKVGQCGIHFTVLREIKIMNEINHPNIMGLRDVFVQGDFINLVMDYMESDLRKVFENRIRFSESHIKCLLKQIILGINELHNWFIIHRDLAPANIFINSKGIAKVGDFGLARSYGQPRREYTPEVVTLWYRCPELLFGSTKYTHAVDMWSIGCIFAELLTGGKALLPGDDEVRQLGRIFELLGTPNEDNWPQAKELPLYCEFSPRSPLNFKDIFPNASEMAIDLIQSFLRLNPLERISASQALEHEYFKSYPLPCDPSELPLNYFKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPQ4</accession>
    <name>A3FPQ4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Autophagy-related protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_3990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the ATG8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388400.1">
        <property type="nucleotide sequence ID" value="XM_001388363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPQ4"/>
    <dbReference type="FunCoup" id="A3FPQ4">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPQ4"/>
    <dbReference type="GeneID" id="3371841"/>
    <dbReference type="KEGG" id="cpv:cgd7_3990"/>
    <dbReference type="InParanoid" id="A3FPQ4"/>
    <dbReference type="OMA" id="AVYQEHK"/>
    <dbReference type="OrthoDB" id="6738456at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006914">
        <property type="term" value="P:autophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd16108">
        <property type="entry name" value="Ubl_ATG8_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004241">
        <property type="entry name" value="Atg8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10969">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEINS 1A/1B LIGHT CHAIN 3-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02991">
        <property type="entry name" value="ATG8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0072">Autophagy</keyword>
    <keyword evidence="4 5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="lipid moiety-binding region" description="Phosphatidylserine amidated glycine; alternate" evidence="5">
        <location>
            <position position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR604241-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="116" mass="13368" checksum="0B2DCA0ACE111493" modified="2007-04-03" version="1" fragment="single">SIRAKYPNRIPVICERSSRSDLPEIEKKKFLVPMNMLVGEFKYIIHKHITQSSNNQNSGIKIPVPYEKTIYLFVNNTIPKAGSLMQEVYEQYVSDDGFLYVEYSSENAFGGYHSII</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPS2</accession>
    <name>A3FPS2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">ATP synthase subunit alpha</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd6_610</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Produces ATP from ADP in the presence of a proton gradient across the membrane.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 10">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388301.1">
        <property type="nucleotide sequence ID" value="XM_001388264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPS2"/>
    <dbReference type="FunCoup" id="A3FPS2">
        <property type="interactions" value="129"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPS2"/>
    <dbReference type="GeneID" id="3375925"/>
    <dbReference type="KEGG" id="cpv:cgd6_610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_610"/>
    <dbReference type="InParanoid" id="A3FPS2"/>
    <dbReference type="OMA" id="INQRDNW"/>
    <dbReference type="OrthoDB" id="9805536at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045259">
        <property type="term" value="C:proton-transporting ATP synthase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046933">
        <property type="term" value="F:proton-transporting ATP synthase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18116">
        <property type="entry name" value="ATP-synt_F1_alpha_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01132">
        <property type="entry name" value="F1-ATPase_alpha_CD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000002">
        <property type="entry name" value="ATP synthase subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.30.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.150.20">
        <property type="entry name" value="ATP synthase alpha/beta chain, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01346">
        <property type="entry name" value="ATP_synth_alpha_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023366">
        <property type="entry name" value="ATP_synth_asu-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000793">
        <property type="entry name" value="ATP_synth_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038376">
        <property type="entry name" value="ATP_synth_asu_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033732">
        <property type="entry name" value="ATP_synth_F1_a_nt-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005294">
        <property type="entry name" value="ATP_synth_F1_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036121">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00962">
        <property type="entry name" value="atpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009884">
        <property type="entry name" value="PRK13343.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48082:SF2">
        <property type="entry name" value="ATP SYNTHASE SUBUNIT ALPHA, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00306">
        <property type="entry name" value="ATP-synt_ab_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47917">
        <property type="entry name" value="C-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50615">
        <property type="entry name" value="N-terminal domain of alpha and beta subunits of F1 ATP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 11" id="KW-0066">ATP synthesis</keyword>
    <keyword evidence="5 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0139">CF(1)</keyword>
    <keyword evidence="10" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="6 10" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 10" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="14">
        <location>
            <begin position="150"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="12">
        <location>
            <begin position="271"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase alpha subunit C-terminal" evidence="13">
        <location>
            <begin position="499"/>
            <end position="633"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023310"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU003551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAZ51495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="639" mass="72921" checksum="F3B07C6E4AC988ED" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPS5</accession>
    <name>A3FPS5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ribonucleotide reductase small subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_700</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51498.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388304.1">
        <property type="nucleotide sequence ID" value="XM_001388267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPS5"/>
    <dbReference type="FunCoup" id="A3FPS5">
        <property type="interactions" value="18"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPS5"/>
    <dbReference type="GeneID" id="3375931"/>
    <dbReference type="KEGG" id="cpv:cgd6_700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_700"/>
    <dbReference type="InParanoid" id="A3FPS5"/>
    <dbReference type="OMA" id="KENQFRW"/>
    <dbReference type="OrthoDB" id="2093646at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51498.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="339" mass="40427" checksum="3947110AC993A4F4" modified="2007-04-03" version="1">MNESKKELLEQQKNESILLDNPFRWVLFPIKYSRLWSLYKKYEVSFWTAEVISPMEDKTKLMNMDEKLLDYIEMAFAKRIYIDNTCLDTVLLTCELLGQVQVPEARGYFSFTMCMENIYKELFMNYVEMIRKNKEKIERTDEVEKKDENNLNSKISKEEYEYNLEKKLNELEDFTKMKELVGNFYDEDTLFSEKLIYYVIIKKIFSSSIHLLRLSFSMRNISESELPTQLCDGLDRIRRDEQYQVEFCLSIAKSMKTKPSNDQVVNLLEQAIMLEKNFIFSIVDPQVLQIEREDIVAFLLFNADEILVDLKYPRQFNVSNPFINIMNDFPCSFSRRSCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPY5</accession>
    <name>A3FPY5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">40S ribosomal subunit protein S9, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_1840</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51466.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388426.1">
        <property type="nucleotide sequence ID" value="XM_001388389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPY5"/>
    <dbReference type="FunCoup" id="A3FPY5">
        <property type="interactions" value="328"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPY5"/>
    <dbReference type="GeneID" id="3374645"/>
    <dbReference type="KEGG" id="cpv:cgd8_1840"/>
    <dbReference type="InParanoid" id="A3FPY5"/>
    <dbReference type="OMA" id="ICCLIHI"/>
    <dbReference type="OrthoDB" id="1697570at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.290.10:FF:000021">
        <property type="entry name" value="40S ribosomal protein S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.290.10">
        <property type="entry name" value="RNA-binding S4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022801">
        <property type="entry name" value="Ribosomal_uS4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018079">
        <property type="entry name" value="Ribosomal_uS4_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005710">
        <property type="entry name" value="Ribosomal_uS4_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002942">
        <property type="entry name" value="S4_RNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036986">
        <property type="entry name" value="S4_RNA-bd_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01018">
        <property type="entry name" value="uS4_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831">
        <property type="entry name" value="30S 40S RIBOSOMAL PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11831:SF5">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01479">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00363">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55174">
        <property type="entry name" value="Alpha-L RNA-binding motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00632">
        <property type="entry name" value="RIBOSOMAL_S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="2 6" id="KW-0699">rRNA-binding</keyword>
    <feature type="domain" description="RNA-binding S4" evidence="8">
        <location>
            <begin position="28"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="86"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51466.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="109" mass="12494" checksum="337A4BA4E194B255" modified="2007-04-03" version="1">MERLGLLSEEERKLDYVLGLTISKFLERRLQTRVFKLGLAKSIHHARVLIRQNHIRVGRQIVDVPSFMVRLDSEKHIDFALTSPFGGGRAGRVRRRTLKNQSGGGEDEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQA7</accession>
    <name>A3FQA7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Peptidyl-prolyl cis-trans isomerase</fullName>
            <shortName evidence="4">PPIase</shortName>
            <ecNumber evidence="4">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_4120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2007-04" db="PDB data bank">
            <title>Cryptosporidium Parvum Cyclophilin Type Peptidyl-Prolyl Cis-Trans Isomerase Cgd2_4120 in Complex with Cyclosporin A.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Lew J."/>
                <person name="Hills T."/>
                <person name="Kozieradzki I."/>
                <person name="Lin Y.H."/>
                <person name="Hassanali A."/>
                <person name="Zhao Y."/>
                <person name="Schapira M."/>
                <person name="Arrowsmith C.H."/>
                <person name="Edwards A.M."/>
                <person name="Weigelt J."/>
                <person name="Sundstrom M."/>
                <person name="Bochkarev A."/>
                <person name="Hui R."/>
                <person name="Artz J.D."/>
                <person name="Xiao T."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 3-170</scope>
    </reference>
    <reference evidence="8" key="3">
        <citation type="submission" date="2007-04" db="PDB data bank">
            <title>Crystal structure of Cryptosporidium parvum cyclophilin type peptidyl-prolyl cis-trans isomerase cgd2_4120.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Lew J."/>
                <person name="Hills T."/>
                <person name="Kozieradzki I."/>
                <person name="Lin Y.H."/>
                <person name="Hassanali A."/>
                <person name="Zhao Y."/>
                <person name="Schapira M."/>
                <person name="Arrowsmith C.H."/>
                <person name="Edwards A.M."/>
                <person name="Weigelt J."/>
                <person name="Sundstrom M."/>
                <person name="Bochkarev A."/>
                <person name="Hui R."/>
                <person name="Artz J.D."/>
                <person name="Xiao T."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.82 ANGSTROMS) OF 3-170</scope>
    </reference>
    <comment type="function">
        <text evidence="4">PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the cyclophilin-type PPIase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388243.1">
        <property type="nucleotide sequence ID" value="XM_001388206.1"/>
    </dbReference>
    <dbReference type="PDB" id="2PLU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.82 A"/>
        <property type="chains" value="A=3-170"/>
    </dbReference>
    <dbReference type="PDB" id="2POY">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A/B/C=3-170"/>
    </dbReference>
    <dbReference type="PDBsum" id="2PLU"/>
    <dbReference type="PDBsum" id="2POY"/>
    <dbReference type="AlphaFoldDB" id="A3FQA7"/>
    <dbReference type="SMR" id="A3FQA7"/>
    <dbReference type="FunCoup" id="A3FQA7">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQA7"/>
    <dbReference type="GeneID" id="3373663"/>
    <dbReference type="KEGG" id="cpv:cgd2_4120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4120"/>
    <dbReference type="InParanoid" id="A3FQA7"/>
    <dbReference type="OMA" id="CSIINSG"/>
    <dbReference type="OrthoDB" id="193499at2759"/>
    <dbReference type="EvolutionaryTrace" id="A3FQA7"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016018">
        <property type="term" value="F:cyclosporin A binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01926">
        <property type="entry name" value="cyclophilin_ABH_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.100.10:FF:000002">
        <property type="entry name" value="Peptidyl-prolyl cis-trans isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024936">
        <property type="entry name" value="Cyclophilin-type_PPIase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020892">
        <property type="entry name" value="Cyclophilin-type_PPIase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11071:SF561">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE D-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001467">
        <property type="entry name" value="Peptidylpro_ismrse"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00170">
        <property type="entry name" value="CSA_PPIASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="8 9" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="5">
        <location>
            <begin position="7"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363019"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="8">
        <source>
            <dbReference type="PDB" id="2PLU"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="9">
        <source>
            <dbReference type="PDB" id="2POY"/>
        </source>
    </evidence>
    <sequence length="172" mass="18544" checksum="709330D5E8C8AAC8" modified="2007-04-03" version="1">MPNPVVYFDISIGQTPAGRITMELFADKVPITAENFRALCTGEKGMGQSGKPLCYTGSFFHRIIPQFMIQGGDFTRGDGTGGESIYGSKFRDENFVYTHDAPFLLSMANAGPNTNGSQFFITTVPCPWLDGKHVVFGKVLEGMEVVKSIEKCGSQNGKPTKSVCITASGVLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQH6</accession>
    <name>A3FQH6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Prefoldin subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 3">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51282.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388260.1">
        <property type="nucleotide sequence ID" value="XM_001388223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQH6"/>
    <dbReference type="FunCoup" id="A3FQH6">
        <property type="interactions" value="395"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQH6"/>
    <dbReference type="GeneID" id="3373366"/>
    <dbReference type="KEGG" id="cpv:cgd5_930"/>
    <dbReference type="InParanoid" id="A3FQH6"/>
    <dbReference type="OMA" id="YNYDVHQ"/>
    <dbReference type="OrthoDB" id="6375174at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015631">
        <property type="term" value="F:tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23156">
        <property type="entry name" value="Prefoldin_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016655">
        <property type="entry name" value="PFD3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12409:SF0">
        <property type="entry name" value="PREFOLDIN SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016396">
        <property type="entry name" value="Prefoldin_subunit_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="129"/>
            <end position="156"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRNR" id="PIRNR016396"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51282.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="180" mass="20655" checksum="D1128D1BD99C02E4" modified="2007-04-03" version="1">MISDLIIKEEVGPGNVPKALFISSIEEFVGDRPVYGILENIQLLNRKYKIMESSIKTQQEYLIAKIPDIELAIESVFQRKKLLNNLNKNELYFPVSDNLFAKCSSPPSNTIYLWLGANTILEYPLEEAIEVLKSNLSTAKNTIKLYQESLDFIREQITIMDVNTARVHNYGVMQRKQNKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQL0</accession>
    <name>A3FQL0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Oxidoreductase, short-chain dehydrogenase family, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_2270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the short-chain dehydrogenases/reductases (SDR) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388065.1">
        <property type="nucleotide sequence ID" value="XM_001388028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQL0"/>
    <dbReference type="FunCoup" id="A3FQL0">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQL0"/>
    <dbReference type="GeneID" id="3372825"/>
    <dbReference type="KEGG" id="cpv:cgd4_2270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2270"/>
    <dbReference type="InParanoid" id="A3FQL0"/>
    <dbReference type="OMA" id="NPWEGAQ"/>
    <dbReference type="OrthoDB" id="1274115at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05327">
        <property type="entry name" value="retinol-DH_like_SDR_c_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002347">
        <property type="entry name" value="SDR_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157:SF31">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43157">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL-GLYCAN BIOSYNTHESIS CLASS F PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00106">
        <property type="entry name" value="adh_short"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00081">
        <property type="entry name" value="GDHRDH"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00080">
        <property type="entry name" value="SDRFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="7"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="52"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000363"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="380" mass="42576" checksum="0082BCD58EDAA1F4" modified="2007-04-03" version="1">MNMPRGMLIYVFLSSVLFEPAFVSMLVFMAGITFPFIFYYLEFIESFNLPHIMNGAAILAYIFVLLGICKFISFGKCLSEKTLKDTNIMKGKTVVITGCSRGIGLETVKQLASWGVSELILCCRDIVAMENVKNQLTSIRLPPNKIHSIECDLSSLQSVELCSRKILSIVDKIDILINNAGIMAPPFQLINGVERQFMTNYLGHYHLTTNLIPLLQRSKCRIINVSSIAHLAVPFGFNISEIENINEKSYNKMRFYGISKLCNIYFTRELQKRFGSAGLTAVSLHPGCVDTDLGRYVRENSIAFALLYPLMKLFSKTSFSGAQTTLYCCSIPEIKLAPGGHYSQCTLDISSPVSLDEDASAQLWDYSKLLCDKIMKSKMK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQL4</accession>
    <name>A3FQL4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51257.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388069.1">
        <property type="nucleotide sequence ID" value="XM_001388032.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQL4"/>
    <dbReference type="STRING" id="353152.A3FQL4"/>
    <dbReference type="GeneID" id="3372821"/>
    <dbReference type="KEGG" id="cpv:cgd4_2710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2710"/>
    <dbReference type="InParanoid" id="A3FQL4"/>
    <dbReference type="OrthoDB" id="747253at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006396">
        <property type="term" value="P:RNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="45"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="54"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51257.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="77" mass="8887" checksum="C22FFE99F3A7EB6B" modified="2007-04-03" version="1">MNLALNNVICNSRDGNGFFKMVECYIRGNNIKLIRISDENINTAKDDMTQRETARLGNRGRPRNETRASRVRSSKWV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="30" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQL6</accession>
    <name>A3FQL6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative mitochondrial inner membrane translocase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_3170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388071.1">
        <property type="nucleotide sequence ID" value="XM_001388034.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQL6"/>
    <dbReference type="GeneID" id="3372818"/>
    <dbReference type="KEGG" id="cpv:cgd4_3170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3170"/>
    <dbReference type="InParanoid" id="A3FQL6"/>
    <dbReference type="OrthoDB" id="159299at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAZ51259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="78" mass="9131" checksum="3A061A1265EA0906" modified="2007-04-03" version="1">MGEPSENKPQSLPNNLFLNDNLKFDKLDLDVTKFRRKQDLYFNSYDRLWGEKVTYSVGLSYGTGMLSPCFFIKQIIMI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPI1</accession>
    <name>Q5CPI1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Magnesium transporter</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_320</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87353.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625368.1">
        <property type="nucleotide sequence ID" value="XM_625368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPI1"/>
    <dbReference type="GeneID" id="3375648"/>
    <dbReference type="KEGG" id="cpv:cgd6_320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_320"/>
    <dbReference type="InParanoid" id="Q5CPI1"/>
    <dbReference type="OMA" id="HQERETS"/>
    <dbReference type="OrthoDB" id="2504919at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015095">
        <property type="term" value="F:magnesium ion transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008521">
        <property type="entry name" value="Mg_trans_NIPA"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12570:SF65">
        <property type="entry name" value="MAGNESIUM TRANSPORTER NIPA9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05653">
        <property type="entry name" value="Mg_trans_NIPA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="46"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="104"/>
            <end position="120"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="140"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="370"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="400"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="434"/>
            <end position="454"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87353.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="808" mass="92388" checksum="6E4B2223B0408FA3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPI4</accession>
    <name>Q5CPI4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87350.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625365.1">
        <property type="nucleotide sequence ID" value="XM_625365.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPI4"/>
    <dbReference type="GeneID" id="3375645"/>
    <dbReference type="KEGG" id="cpv:cgd6_290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_290"/>
    <dbReference type="InParanoid" id="Q5CPI4"/>
    <dbReference type="OrthoDB" id="342791at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87350.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="317" mass="38252" checksum="0FB56E9BC10FC1A3" modified="2005-04-12" version="1">MVNNKEEYLIKEIILENLPINERIRIKRKLICEEMDLKDINDDEIWKIIKKDSKYMTKLKTNIVGLFKIIQFLRLNYDKYTITEYCDNIQELIILDINENIELDELLLNDINENLSRIIFKNINKIKFINSNIILNNYEINYWLDWLFNNITLNGKYGLELYFKDCRFYYNNISKSQTLRIDNKRRKILNNNNQNMEENKSFMFSLLSKIMNNMNLIKEKLLSFNLVNIVIDQIELRNIFDLILNKMEIKLSELNISQLLLFDDTKKKIRNQVYLNNIIKYMNLEKMGTNLMNLRILSFHSNHLNDENALLIMKEFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPK0</accession>
    <name>Q5CPK0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Mechanosensitive ion channel protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_90</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the MscS (TC 1.A.23) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625349.1">
        <property type="nucleotide sequence ID" value="XM_625349.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPK0"/>
    <dbReference type="FunCoup" id="Q5CPK0">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPK0"/>
    <dbReference type="GeneID" id="3375668"/>
    <dbReference type="KEGG" id="cpv:cgd6_90"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_90"/>
    <dbReference type="InParanoid" id="Q5CPK0"/>
    <dbReference type="OMA" id="NVLYMCS"/>
    <dbReference type="OrthoDB" id="544685at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008381">
        <property type="term" value="F:mechanosensitive monoatomic ion channel activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006820">
        <property type="term" value="P:monoatomic anion transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016688">
        <property type="entry name" value="MscS-like_plants/fungi"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023408">
        <property type="entry name" value="MscS_beta-dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006685">
        <property type="entry name" value="MscS_channel_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618:SF1">
        <property type="entry name" value="EF-HAND DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31618">
        <property type="entry name" value="MECHANOSENSITIVE ION CHANNEL PROTEIN 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00924">
        <property type="entry name" value="MS_channel_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017209">
        <property type="entry name" value="Memb_At2g17000_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="557"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="domain" description="Mechanosensitive ion channel MscS" evidence="9">
        <location>
            <begin position="594"/>
            <end position="661"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="427"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="452"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="455"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="468"/>
            <end position="485"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008017"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR017209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="779" mass="89502" checksum="F27D5246C36FFC16" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPK3</accession>
    <name>Q5CPK3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_60</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87336.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625346.1">
        <property type="nucleotide sequence ID" value="XM_625346.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPK3"/>
    <dbReference type="GeneID" id="3375667"/>
    <dbReference type="KEGG" id="cpv:cgd6_60"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_60"/>
    <dbReference type="InParanoid" id="Q5CPK3"/>
    <dbReference type="OMA" id="NIMMIAK"/>
    <dbReference type="OrthoDB" id="341547at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216:SF65">
        <property type="entry name" value="PAXILLIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24216">
        <property type="entry name" value="PAXILLIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1414"/>
            <end position="1562"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1414"/>
            <end position="1427"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1436"/>
            <end position="1449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1505"/>
            <end position="1518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="1520"/>
            <end position="1562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87336.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1562" mass="169129" checksum="854D282FCFFCE01B" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPP5</accession>
    <name>Q5CPP5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Nucleolar protein 56</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_50</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP5/NOP56 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87391.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625376.1">
        <property type="nucleotide sequence ID" value="XM_625376.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPP5"/>
    <dbReference type="FunCoup" id="Q5CPP5">
        <property type="interactions" value="467"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPP5"/>
    <dbReference type="GeneID" id="3372341"/>
    <dbReference type="KEGG" id="cpv:cgd2_50"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_50"/>
    <dbReference type="InParanoid" id="Q5CPP5"/>
    <dbReference type="OMA" id="PDNYMFA"/>
    <dbReference type="OrthoDB" id="6780543at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.246.90:FF:000001">
        <property type="entry name" value="Nucleolar protein 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.4070">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.246.90">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045056">
        <property type="entry name" value="Nop56/Nop58"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012974">
        <property type="entry name" value="NOP58/56_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042239">
        <property type="entry name" value="Nop_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002687">
        <property type="entry name" value="Nop_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036070">
        <property type="entry name" value="Nop_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012976">
        <property type="entry name" value="NOSIC"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894">
        <property type="entry name" value="NUCLEOLAR PROTEIN 5 NUCLEOLAR PROTEIN NOP5 NOP58"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10894:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 56"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01798">
        <property type="entry name" value="Nop"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08156">
        <property type="entry name" value="NOP5NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00931">
        <property type="entry name" value="NOSIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89124">
        <property type="entry name" value="Nop domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51358">
        <property type="entry name" value="NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Nop" evidence="7">
        <location>
            <begin position="298"/>
            <end position="416"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="442"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="473"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="484"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00040742"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51358"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87391.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="499" mass="56699" checksum="AB117236D2366D44" modified="2005-04-12" version="1">MSGDKKLYVLFESAAGYLLCIIDNWEEIGQVTESVIEVCADPMRFGQVAQFFAFFPFQTAEMALENMKEIQNGNATEELKTFLIQNLPKKVKKYNLGVGDASLGKTLSDQGYPVVIDKNINELLRGIRIHFTRIVKSFDSSIGDLHKFQVGLGHSFSRNKLQFDPNKQDKSIVQSIALIDRLDKDINLFSMRCREWYSWHFPELAKIITDTEKFLKVAVLIGDKDKFEDNEETRKKISKIVDDPSLEEDIFSSILISMGQDITDNDMNMIKSLAKQLIALYKQRSHLIDYLNNRLYNVAPNLQSLLGDTLAARLIAHSGSLVNLAKSPASTIQVLGAEKALFRALKSKGNTPKYGLLFQSTYIGKASQKNKGRISRYLANKCSIAARIDNFSTVNNNIFGEKLKQQVEDRLKYLSEGISPPKNIDIMREAISENQDILKNTISNQLDSDKKKKKKRKSHESIQNEQDEDDQQEQMRDNDESSEKKKKKKRKSSGKGDDE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPQ1</accession>
    <name>Q5CPQ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_4490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87403.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625463.1">
        <property type="nucleotide sequence ID" value="XM_625463.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPQ1"/>
    <dbReference type="GeneID" id="3372437"/>
    <dbReference type="KEGG" id="cpv:cgd4_4490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4490"/>
    <dbReference type="InParanoid" id="Q5CPQ1"/>
    <dbReference type="OMA" id="PESAFSW"/>
    <dbReference type="OrthoDB" id="343820at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254801" evidence="2">
        <location>
            <begin position="26"/>
            <end position="938"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="668"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="486"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="538"/>
            <end position="550"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="594"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="595"/>
            <end position="611"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="668"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="723"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="741"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="814"/>
            <end position="831"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87403.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="938" mass="107876" checksum="F3CA65D99798AAAC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="100" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPX0</accession>
    <name>Q5CPX0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Histone deactylase of possible bacterial origin with ankyrin repeats at the N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625509.1">
        <property type="nucleotide sequence ID" value="XM_625509.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPX0"/>
    <dbReference type="STRING" id="353152.Q5CPX0"/>
    <dbReference type="GeneID" id="3372454"/>
    <dbReference type="KEGG" id="cpv:cgd8_480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_480"/>
    <dbReference type="InParanoid" id="Q5CPX0"/>
    <dbReference type="OMA" id="VACTEND"/>
    <dbReference type="OrthoDB" id="424012at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004407">
        <property type="term" value="F:histone deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0040029">
        <property type="term" value="P:epigenetic regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11599">
        <property type="entry name" value="HDAC_classII_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.800.20">
        <property type="entry name" value="Histone deacetylase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023801">
        <property type="entry name" value="His_deacetylse_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037138">
        <property type="entry name" value="His_deacetylse_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023696">
        <property type="entry name" value="Ureohydrolase_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625:SF26">
        <property type="entry name" value="HISTONE DEACETYLASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10625">
        <property type="entry name" value="HISTONE DEACETYLASE HDAC1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00850">
        <property type="entry name" value="Hist_deacetyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52768">
        <property type="entry name" value="Arginase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="252"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="domain" description="Histone deacetylase" evidence="3">
        <location>
            <begin position="442"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="875"/>
            <end position="918"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="906"/>
            <end position="915"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="973" mass="107861" checksum="ED6C17773D3FAF45" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPY7</accession>
    <name>Q5CPY7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Serine-threonine protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87480.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625492.1">
        <property type="nucleotide sequence ID" value="XM_625492.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPY7"/>
    <dbReference type="FunCoup" id="Q5CPY7">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPY7"/>
    <dbReference type="DNASU" id="3372510"/>
    <dbReference type="GeneID" id="3372510"/>
    <dbReference type="KEGG" id="cpv:cgd8_290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_290"/>
    <dbReference type="InParanoid" id="Q5CPY7"/>
    <dbReference type="OMA" id="SHWMRGL"/>
    <dbReference type="OrthoDB" id="5976022at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07425">
        <property type="entry name" value="MPP_Shelphs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041787">
        <property type="entry name" value="MPP_Shelphs"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46546:SF4">
        <property type="entry name" value="SHEWANELLA-LIKE PROTEIN PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="1">
        <location>
            <begin position="87"/>
            <end position="297"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87480.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="385" mass="43817" checksum="FBF87BAAB078F20C" modified="2005-04-12" version="1">MRKLLKKTLFSNIIILCLYLGILKCVNSHISNEIQKQNQTFDKENLESKNTQNLQKSKNPTSQLSKTILKEEFNFLPNDVEINWKGRVLVIGDIHGDLKSLITSLFLSGVINSNLDWIAKNTLLIQLGDVVDRGSHALQIYKLFNKLKSQAPSLGSKFVGLLGNHEVMNLCGQLHYVTDEDFQTYGGRDNRTFEWSKEGFVGKYLRTMKLAIRVNDSLYVHAGLLPKYAKLGLDKLDKLSNDLLEGDFCDFYSSLFFVEDGPLWTRDISLGEEEKACKLVDETLQILGLSRMVVGHTIQHDNRINIKCDNKLILADTGFSEAIYGKPCMLEILYHNDNPDPSNYKSFHPYSINELQVKSNPSKPNIKYIQVTSLFLDKTSTRDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ11</accession>
    <name>Q5CQ11_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide, predicted secreted protein of cryptosprodidium-specific SKSR gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_40</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87457.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625468.1">
        <property type="nucleotide sequence ID" value="XM_625468.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ11"/>
    <dbReference type="STRING" id="353152.Q5CQ11"/>
    <dbReference type="GeneID" id="3372487"/>
    <dbReference type="KEGG" id="cpv:cgd8_40"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_40"/>
    <dbReference type="InParanoid" id="Q5CQ11"/>
    <dbReference type="OrthoDB" id="343956at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254393" evidence="2">
        <location>
            <begin position="26"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="460"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="680"/>
            <end position="778"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="470"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="490"/>
            <end position="499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="524"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="542"/>
            <end position="572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="582"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="680"/>
            <end position="697"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="737"/>
            <end position="748"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87457.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="884" mass="101810" checksum="8D80FB1C5C4A63E3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQB6</accession>
    <name>Q5CQB6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ring domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd4_1360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87615.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625732.1">
        <property type="nucleotide sequence ID" value="XM_625732.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQB6"/>
    <dbReference type="FunCoup" id="Q5CQB6">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQB6"/>
    <dbReference type="GeneID" id="3372642"/>
    <dbReference type="KEGG" id="cpv:cgd4_1360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1360"/>
    <dbReference type="InParanoid" id="Q5CQB6"/>
    <dbReference type="OMA" id="EIKMLCR"/>
    <dbReference type="OrthoDB" id="1711136at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16649">
        <property type="entry name" value="mRING-HC-C3HC5_CGRF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="29"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="635"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="160"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87615.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="686" mass="79275" checksum="64A0FC436BD809E3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQC0</accession>
    <name>Q5CQC0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Glycine zipper domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87617.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625728.1">
        <property type="nucleotide sequence ID" value="XM_625728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQC0"/>
    <dbReference type="STRING" id="353152.Q5CQC0"/>
    <dbReference type="GeneID" id="3372644"/>
    <dbReference type="KEGG" id="cpv:cgd4_1310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1310"/>
    <dbReference type="InParanoid" id="Q5CQC0"/>
    <dbReference type="OMA" id="IHIHEIQ"/>
    <dbReference type="OrthoDB" id="340343at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039567">
        <property type="entry name" value="Gly-zipper"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13488">
        <property type="entry name" value="Gly-zipper_Omp"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycine zipper" evidence="1">
        <location>
            <begin position="451"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF13488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87617.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="597" mass="68266" checksum="94F44F4FEA896260" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQC5</accession>
    <name>Q5CQC5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">tRNA-intron lyase</fullName>
            <ecNumber evidence="2">4.6.1.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd4_1260</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>pretRNA = a 3'-half-tRNA molecule with a 5'-OH end + a 5'-half-tRNA molecule with a 2',3'-cyclic phosphate end + an intron with a 2',3'-cyclic phosphate and a 5'-hydroxyl terminus.</text>
            <dbReference type="EC" id="4.6.1.16"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA-intron endonuclease family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.6.1.16" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625723.1">
        <property type="nucleotide sequence ID" value="XM_625723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQC5"/>
    <dbReference type="STRING" id="353152.Q5CQC5"/>
    <dbReference type="GeneID" id="3372618"/>
    <dbReference type="KEGG" id="cpv:cgd4_1260"/>
    <dbReference type="InParanoid" id="Q5CQC5"/>
    <dbReference type="OMA" id="CILICKF"/>
    <dbReference type="OrthoDB" id="48041at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000213">
        <property type="term" value="F:tRNA-intron lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006388">
        <property type="term" value="P:tRNA splicing, via endonucleolytic cleavage and ligation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22363">
        <property type="entry name" value="tRNA-intron_lyase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1350.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011856">
        <property type="entry name" value="tRNA_endonuc-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036167">
        <property type="entry name" value="tRNA_intron_Endo_cat-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006677">
        <property type="entry name" value="tRNA_intron_Endonuc_cat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006676">
        <property type="entry name" value="tRNA_splic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21227:SF0">
        <property type="entry name" value="TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01974">
        <property type="entry name" value="tRNA_int_endo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53032">
        <property type="entry name" value="tRNA-intron endonuclease catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA intron endonuclease catalytic" evidence="4">
        <location>
            <begin position="24"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00034031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF01974"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="158" mass="19134" checksum="B585B2286A60D598" modified="2005-04-12" version="1" fragment="single">YYQTYENISNIYNKFQFNQENLILLKYIIYKYFKEKNYIVKDGMKFGVDYILYHKSPSLVHGKHCILICKFTYEEKEKKKENGNNDYCYNKSDLSKYDGYEEIIYNNKKYMVKFPIINYKKIINLSRLCESVSKKLILVEYNSKNDEIQSLEISRFSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQI2</accession>
    <name>Q5CQI2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Diphthine--ammonia ligase</fullName>
            <ecNumber evidence="1">6.3.1.14</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="3">Diphthamide synthase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="4">Diphthamide synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_610</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>diphthine-[translation elongation factor 2] + NH4(+) + ATP = diphthamide-[translation elongation factor 2] + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:19753"/>
            <dbReference type="Rhea" id="RHEA-COMP:10172"/>
            <dbReference type="Rhea" id="RHEA-COMP:10174"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:16692"/>
            <dbReference type="ChEBI" id="CHEBI:28938"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:82696"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.3.1.14"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.1.14" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87667.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625666.1">
        <property type="nucleotide sequence ID" value="XM_625666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQI2"/>
    <dbReference type="STRING" id="353152.Q5CQI2"/>
    <dbReference type="GeneID" id="3372752"/>
    <dbReference type="KEGG" id="cpv:cgd4_610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_610"/>
    <dbReference type="InParanoid" id="Q5CQI2"/>
    <dbReference type="OMA" id="LWIIRID"/>
    <dbReference type="OrthoDB" id="686384at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017178">
        <property type="term" value="F:diphthine-ammonia ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017183">
        <property type="term" value="P:protein histidyl modification to diphthamide"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01994">
        <property type="entry name" value="AANH_PF0828-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.620:FF:000145">
        <property type="entry name" value="ATP-binding domain containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1490.10">
        <property type="entry name" value="putative n-type atp pyrophosphatase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002761">
        <property type="entry name" value="Diphthami_syn_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030662">
        <property type="entry name" value="DPH6/MJ0570"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00290">
        <property type="entry name" value="MJ0570_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196:SF2">
        <property type="entry name" value="DIPHTHINE--AMMONIA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12196">
        <property type="entry name" value="DOMAIN OF UNKNOWN FUNCTION 71 DUF71 -CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01902">
        <property type="entry name" value="Diphthami_syn_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Diphthamide synthase" evidence="6">
        <location>
            <begin position="5"/>
            <end position="227"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00018426"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00029814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048108"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01902"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87667.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="777" mass="89282" checksum="09EFEF31DAF2B714" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQI3</accession>
    <name>Q5CQI3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87668.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625665.1">
        <property type="nucleotide sequence ID" value="XM_625665.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQI3"/>
    <dbReference type="STRING" id="353152.Q5CQI3"/>
    <dbReference type="GeneID" id="3372753"/>
    <dbReference type="KEGG" id="cpv:cgd4_600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_600"/>
    <dbReference type="InParanoid" id="Q5CQI3"/>
    <dbReference type="OMA" id="SHICSES"/>
    <dbReference type="OrthoDB" id="343715at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2050">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="260"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="260"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87668.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="638" mass="69530" checksum="43E2176F2041B9EF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQQ5</accession>
    <name>Q5CQQ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ser/Thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_3710</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625947.1">
        <property type="nucleotide sequence ID" value="XM_625947.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQQ5"/>
    <dbReference type="STRING" id="353152.Q5CQQ5"/>
    <dbReference type="GeneID" id="3372801"/>
    <dbReference type="KEGG" id="cpv:cgd4_3710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3710"/>
    <dbReference type="InParanoid" id="Q5CQQ5"/>
    <dbReference type="OMA" id="QDMSSIN"/>
    <dbReference type="OrthoDB" id="341691at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000776">
        <property type="term" value="C:kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004712">
        <property type="term" value="F:protein serine/threonine/tyrosine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033316">
        <property type="term" value="P:meiotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007094">
        <property type="term" value="P:mitotic spindle assembly checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034501">
        <property type="term" value="P:protein localization to kinetochore"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974:SF21">
        <property type="entry name" value="DUAL SPECIFICITY PROTEIN KINASE TTK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22974">
        <property type="entry name" value="MIXED LINEAGE PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="492"/>
            <end position="929"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="241"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="532"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="714"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="837"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="241"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="532"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="562"/>
            <end position="571"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="572"/>
            <end position="586"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="724"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="840"/>
            <end position="850"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1079" mass="119847" checksum="F0D8B931E1E23192" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQT0</accession>
    <name>Q5CQT0_CRYPI</name>
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        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
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        <name evidence="4" type="ORF">cgd4_3460</name>
    </gene>
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        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
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        <lineage>
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            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
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            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
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        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
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                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
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            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87780.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_625922.1"/>
    </dbReference>
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    <dbReference type="SMR" id="Q5CQT0"/>
    <dbReference type="GeneID" id="3372865"/>
    <dbReference type="KEGG" id="cpv:cgd4_3460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3460"/>
    <dbReference type="InParanoid" id="Q5CQT0"/>
    <dbReference type="OrthoDB" id="343621at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254846" evidence="3">
        <location>
            <begin position="26"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="79"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="132"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="181"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="357"/>
            <end position="514"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="229"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="79"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="156"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="2">
        <location>
            <begin position="367"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="378"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="406"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="474"/>
            <end position="489"/>
        </location>
    </feature>
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        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87780.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="742" mass="82362" checksum="B43ECF6DDA7166CF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR43</accession>
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        <submittedName>
            <fullName evidence="9">Uncharacterized protein</fullName>
        </submittedName>
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        <name evidence="9" type="ORF">cgd4_2180</name>
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        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
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            <taxon>Eucoccidiorida</taxon>
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        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
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                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
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            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
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        <subcellularLocation>
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            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the dpy-19 family.</text>
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    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
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    </dbReference>
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        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
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        <property type="project" value="TreeGrafter"/>
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        <property type="entry name" value="Dpy-19/Dpy-19-like"/>
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        <property type="entry name" value="C-MANNOSYLTRANSFERASE DPY19L1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR31488">
        <property type="entry name" value="DPY-19-LIKE 1, LIKE (H. SAPIENS)"/>
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    </dbReference>
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    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
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            <end position="59"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="205"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="230"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <begin position="242"/>
            <end position="261"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="273"/>
            <end position="306"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="318"/>
            <end position="338"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="344"/>
            <end position="362"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="390"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
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            <end position="461"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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    <feature type="transmembrane region" description="Helical" evidence="8">
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            <end position="625"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="646"/>
            <end position="663"/>
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    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
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    </evidence>
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        <source>
            <dbReference type="SAM" id="Phobius"/>
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    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAK87869.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
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</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR64</accession>
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            <fullName evidence="3">nucleoside-diphosphate kinase</fullName>
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        <name evidence="9" type="ORF">cgd4_1940</name>
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        <lineage>
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            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
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                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
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            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="15" key="2">
        <citation type="submission" date="2025-04" db="PDB data bank">
            <title>Crystal structure of nucleoside-diphosphate kinase Cryptosporidium parvum in complex with ADP and CTP.</title>
            <authorList>
                <person name="Liu L."/>
                <person name="Lovell S."/>
                <person name="Battaile K.P."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 26-173 IN COMPLEX WITH ADP AND CTP</scope>
    </reference>
    <reference evidence="13" key="3">
        <citation type="submission" date="2025-04" db="PDB data bank">
            <title>Crystal structure of nucleoside-diphosphate kinase Cryptosporidium parvum in complex with cytidine-5'-diphosphate and cytidine-5'-triphosphate.</title>
            <authorList>
                <person name="Liu L."/>
                <person name="Lovell S."/>
                <person name="Battaile K.P."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.61 ANGSTROMS) OF 26-173 IN COMPLEX WITH CDP; CTP AND MG(2+)</scope>
    </reference>
    <reference evidence="14" key="4">
        <citation type="submission" date="2025-04" db="PDB data bank">
            <title>Crystal structure of nucleoside-diphosphate kinase Cryptosporidium parvum in complex with guanosine-5'-diphosphate and AMP-PNP.</title>
            <authorList>
                <person name="Liu L."/>
                <person name="Lovell S."/>
                <person name="Battaile K.P."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.63 ANGSTROMS) OF 26-173 IN COMPLEX WITH GDP</scope>
    </reference>
    <reference evidence="12" key="5">
        <citation type="submission" date="2025-04" db="PDB data bank">
            <title>Crystal structure of nucleoside-diphosphate kinase Cryptosporidium parvum in complex with thymidine-5'-phosphate.</title>
            <authorList>
                <person name="Liu L."/>
                <person name="Lovell S."/>
                <person name="Battaile K.P."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.51 ANGSTROMS) OF 26-173 IN COMPLEX WITH DTMP</scope>
    </reference>
    <reference evidence="11" key="6">
        <citation type="submission" date="2025-04" db="PDB data bank">
            <title>Crystal structure of nucleoside-diphosphate kinase Cryptosporidium parvum.</title>
            <authorList>
                <person name="Liu L."/>
                <person name="Lovell S."/>
                <person name="Battaile K.P."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.31 ANGSTROMS) OF 26-173</scope>
    </reference>
    <reference evidence="16" key="7">
        <citation type="submission" date="2025-04" db="PDB data bank">
            <title>Crystal structure of nucleoside-diphosphate kinase from Cryptosporidium parvum containing phosphorylated active site histidine.</title>
            <authorList>
                <person name="Liu L."/>
                <person name="Lovell S."/>
                <person name="Battaile K.P."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.58 ANGSTROMS) OF 26-173</scope>
    </reference>
    <reference evidence="17" key="8">
        <citation type="submission" date="2025-04" db="PDB data bank">
            <title>Crystal structure of nucleoside-diphosphate kinase from Cryptosporidium parvum in complex with ADP.</title>
            <authorList>
                <person name="Liu L."/>
                <person name="Lovell S."/>
                <person name="Battaile K.P."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.62 ANGSTROMS) OF 26-173 IN COMPLEX WITH ADP</scope>
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        <citation type="submission" date="2025-04" db="PDB data bank">
            <title>Crystal structure of nucleoside-diphosphate kinase from Cryptosporidium parvum in complex with citrate.</title>
            <authorList>
                <person name="Liu L."/>
                <person name="Lovell S."/>
                <person name="Battaile K.P."/>
            </authorList>
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        <scope>X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 26-173</scope>
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    <reference evidence="20" key="10">
        <citation type="submission" date="2025-07" db="PDB data bank">
            <title>Crystal structure of nucleoside-diphosphate kinase Cryptosporidium parvum in complex with AMP.</title>
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                <person name="Enayati P."/>
                <person name="Liu L."/>
                <person name="Lovell S."/>
                <person name="Battaile K.P."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 26-173 IN COMPLEX WITH AMP</scope>
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    <reference evidence="19" key="11">
        <citation type="submission" date="2025-07" db="PDB data bank">
            <title>Crystal structure of nucleoside-diphosphate kinase Cryptosporidium parvum in complex with ATP.</title>
            <authorList>
                <person name="Liu L."/>
                <person name="Lovell S."/>
                <person name="Battaile K.P."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.42 ANGSTROMS) OF 26-173 IN COMPLEX WITH ATP AND MG(2+)</scope>
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        <text evidence="2 6 7">Belongs to the NDK family.</text>
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        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
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        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <label>1</label>
        </ligand>
    </feature>
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        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="136"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="20">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>AMP</name>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <note>covalent</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>CDP</name>
            <dbReference type="ChEBI" id="CHEBI:58069"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <label>2</label>
            <note>covalent</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13 19">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="139"/>
        </location>
        <ligand>
            <name>dTMP</name>
            <dbReference type="ChEBI" id="CHEBI:63528"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
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        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <label>1</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="140"/>
        </location>
        <ligand>
            <name>CTP</name>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <label>2</label>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15 17">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ADP</name>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="173"/>
        </location>
        <ligand>
            <name>GDP</name>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008142"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87947.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="11">
        <source>
            <dbReference type="PDB" id="9O9R"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="9OAI"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="9OAK"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="9OAN"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="15">
        <source>
            <dbReference type="PDB" id="9OB9"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="16">
        <source>
            <dbReference type="PDB" id="9OBA"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="9OBC"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="9OD6"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="9PFY"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="9PG0"/>
        </source>
    </evidence>
    <sequence length="173" mass="19399" checksum="76A9CD2111982901" modified="2005-04-12" version="1" fragment="single">SKISIYKQSFSFPRVSTAPVIKNMQVEQTYLMIKPDGIQRQVVGEIISRFEKRGYRIAAMKLTIATPAILEEHYAEHKGKPFLPGLIEKMTGPVLCMVFEGVDVIAQARKMMGSTRPGEAAPGTIRADFCQQAGRNLIHGSDSAESAKREISLWFKPEEIQSYKLALSDYIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRD6</accession>
    <name>Q5CRD6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Proteasome subunit beta7 NTN hydrolase fold</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88023.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626250.1">
        <property type="nucleotide sequence ID" value="XM_626250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRD6"/>
    <dbReference type="FunCoup" id="Q5CRD6">
        <property type="interactions" value="602"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRD6"/>
    <dbReference type="GeneID" id="3373043"/>
    <dbReference type="KEGG" id="cpv:cgd5_3220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3220"/>
    <dbReference type="InParanoid" id="Q5CRD6"/>
    <dbReference type="OMA" id="QPIMRRY"/>
    <dbReference type="OrthoDB" id="10248542at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005839">
        <property type="term" value="C:proteasome core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051603">
        <property type="term" value="P:proteolysis involved in protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023333">
        <property type="entry name" value="Proteasome_suB-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194">
        <property type="entry name" value="METALLOPROTEASE TLDD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32194:SF6">
        <property type="entry name" value="PROTEASOME SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0647">Proteasome</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88023.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="310" mass="35359" checksum="CBDFFA1F1B2877B9" modified="2005-04-12" version="1">MLKVSQLRNNKGGVMSLGGETEQQRFDSTNIMEESKKNSSRVIVNSGSAVGIKYKDGIMLISSPLLCYGSMKMNSDISRFHVIGSGMIDLYDERQKLKSKDEDMSSVNTDKRPLVRKLTEVDEDAKVRFYEGKLSVIVSTGEFSDFQNIIERVEEKAAEDFFEGNFKSAKEYSGYISAVHYQRRNKMDPLLNDIIVAGLRKDGSKEIYSVDPLGTRFDEDFIASGMAEYLAITLLRDKYKPDMSFDEAKLILEDCMKNSFYIECKGARMVQIATINQDGTRIYPKYPLDVTWRHDLFVKSNLDRKDYVGF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRG3</accession>
    <name>Q5CRG3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">F11M21.28-like 3 CCH RNA binding domain protein involved in RNA metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_2870</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88000.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626223.1">
        <property type="nucleotide sequence ID" value="XM_626223.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRG3"/>
    <dbReference type="GeneID" id="3373238"/>
    <dbReference type="KEGG" id="cpv:cgd5_2870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2870"/>
    <dbReference type="InParanoid" id="Q5CRG3"/>
    <dbReference type="OrthoDB" id="20534at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045234">
        <property type="entry name" value="Unkempt-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493:SF50">
        <property type="entry name" value="RING FINGER PROTEIN UNKEMPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14493">
        <property type="entry name" value="UNKEMPT FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="5">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="14"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="58"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88000.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="356" mass="41456" checksum="4311E9E8CCDF6E1E" modified="2005-04-12" version="1">MACPRLLSDNDLCRFRTKPCRRSKQMGCDFGITRCQYSHNIYWPRRCPFYLSNQSTIRYIPVLCPDIIIKEDESSISHCNRGGGCPFAHSYEEINYHPLMYKTKICEQFQRGDCNTYYCHLIHGLAERRESKVYLLPYTQNVQVPNFPGVVIANRVNKPFVANSQLNYQTQKSLVNNENICNNHENGFIIRRNNFENMISDKWSERIFSQNNNGDDFWKSTENDELTTMDSISKSESENNNCENMKSSKLVTKTPAPHALNRIENDKSVQEKMRNENILNVFRAFVLEDNDILSVSNDNCRVQAINSTLSNNKIQQLKVRNENLQTQEHSKSFNHIIEDSEIIKNNENSNTSNFFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRM3</accession>
    <name>Q5CRM3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88206.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626163.1">
        <property type="nucleotide sequence ID" value="XM_626163.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRM3"/>
    <dbReference type="GeneID" id="3373344"/>
    <dbReference type="KEGG" id="cpv:cgd5_2250"/>
    <dbReference type="InParanoid" id="Q5CRM3"/>
    <dbReference type="OMA" id="CSGDDCS"/>
    <dbReference type="OrthoDB" id="343811at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="51"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="156"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="273"/>
            <end position="296"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="324"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="628"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="859"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="65"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="81"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="158"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="274"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="628"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="651"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="661"/>
            <end position="671"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="672"/>
            <end position="719"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="720"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88206.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1439" mass="168513" checksum="F45DA59196BB2FA8" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRN1</accession>
    <name>Q5CRN1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_2170</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626155.1">
        <property type="nucleotide sequence ID" value="XM_626155.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRN1"/>
    <dbReference type="GeneID" id="3373112"/>
    <dbReference type="KEGG" id="cpv:cgd5_2170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2170"/>
    <dbReference type="InParanoid" id="Q5CRN1"/>
    <dbReference type="OMA" id="WIELYVE"/>
    <dbReference type="OrthoDB" id="336026at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="124" mass="15116" checksum="5F2B9103D7A46ACE" modified="2005-04-12" version="1">MLSEKEKSIEYLKKIKEFRHKIDTGIIKLKNRLSNYLQEPLYDYLDDTRKEVDQLYNETRMYVYSHETPFNPRYATDDELISRYSMAKLIDIKTRKLMDKTINMLSLENERHIELMQKEGFYGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRY2</accession>
    <name>Q5CRY2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apicomplexan conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1030</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88136.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626054.1">
        <property type="nucleotide sequence ID" value="XM_626054.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRY2"/>
    <dbReference type="FunCoup" id="Q5CRY2">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRY2"/>
    <dbReference type="GeneID" id="3373078"/>
    <dbReference type="KEGG" id="cpv:cgd5_1030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1030"/>
    <dbReference type="InParanoid" id="Q5CRY2"/>
    <dbReference type="OMA" id="ICKMETT"/>
    <dbReference type="OrthoDB" id="343414at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="107"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88136.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="400" mass="45391" checksum="2CB7148B92FE8234" modified="2005-04-12" version="1">MFQDIDSLSVKYEPSISPNNTADPNQINIRIRDSNSKHCIGRQLSQKNSNYAAIIDKGTHYEFKFLDGLFVFDPSIKGKNESNSDVAENLKRDYISREAAVTARIQESSNKMRTKLENDAEDDQTPESDTNKNLGIFNSSCENNVIPGVMRGILDDIYDKDFGLKRQEKKRKISAMLNKENSDDSRIVVSALSLTTLKSGDYWDYDGDGKMSDDEGYIEKNEMDEKFEEEHNPNLVNGNDYSNSEDDEGPDGILTEYGQTLKTMIANQQDMEADEELNLYSDEIDDDVESKSNISSSAPVTVNTNIQFEIQKKTVKSPTALSSSINGFSRSLEAEVIRKLSLAGGRMQIKPFLDAMKVKKKNKYFEEIQEIIKKVADTHTEYHSNMKISYITLKSNYRQR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS60</accession>
    <name>Q5CS60_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">CDC5 cell division cycle 5-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd5_110</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CEF1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625976.1">
        <property type="nucleotide sequence ID" value="XM_625976.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS60"/>
    <dbReference type="FunCoup" id="Q5CS60">
        <property type="interactions" value="355"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS60"/>
    <dbReference type="GeneID" id="3373318"/>
    <dbReference type="KEGG" id="cpv:cgd5_110"/>
    <dbReference type="InParanoid" id="Q5CS60"/>
    <dbReference type="OMA" id="EMYKMQA"/>
    <dbReference type="OrthoDB" id="1410009at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000974">
        <property type="term" value="C:Prp19 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd11659">
        <property type="entry name" value="SANT_CDC5_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000021">
        <property type="entry name" value="CDC5 cell division cycle 5-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047242">
        <property type="entry name" value="CDC5L/Cef1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021786">
        <property type="entry name" value="Cdc5p/Cef1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047240">
        <property type="entry name" value="SANT_CDC5L_II"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45885:SF1">
        <property type="entry name" value="CELL DIVISION CYCLE 5-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11831">
        <property type="entry name" value="Myb_Cef"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="11" id="KW-0132">Cell division</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="5"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="11"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="10">
        <location>
            <begin position="57"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="9">
        <location>
            <begin position="57"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="116"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="250"/>
            <end position="279"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="116"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="254"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010506"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="800" mass="93284" checksum="150428469F2A88AA" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS90</accession>
    <name>Q5CS90_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88294.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628177.1">
        <property type="nucleotide sequence ID" value="XM_628177.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS90"/>
    <dbReference type="STRING" id="353152.Q5CS90"/>
    <dbReference type="GeneID" id="3371520"/>
    <dbReference type="KEGG" id="cpv:cgd1_3650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3650"/>
    <dbReference type="InParanoid" id="Q5CS90"/>
    <dbReference type="OMA" id="AREHNDG"/>
    <dbReference type="OrthoDB" id="343158at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254322" description="Secreted protein" evidence="1">
        <location>
            <begin position="25"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88294.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40966" checksum="7B3A84EE63533F7A" modified="2005-04-12" version="1">MMKVRLILTFKLFFEILFFALASALDLDLNKSDTVNLRISSQQLEQTYNFFTKKLSNSEKENLIKLNSSSEYARSTIPKGAGYDFTVQMAIYTLSESLYINRKYFKVDLISDSKKNKDIFEIANCLYSTSRSTLKTLKLVKQRCFHHSESSQLNIFPKKVAKKLELYCNKFKKIEVRYARLSDFIYLLKMILKKSKIHNSNLLELSKLIWGIIKSPSFKKIKFSKDLSAPISSQNPAIKPSKKEAATISKISFLLRHIDNTLLEKIKILPFWIFKVSDEFSIILIESQSIANRIWSPLEEQIESNLKKLRKCTSSKRQSCCSHKSKKYKLSRDEKFIKNVRDVANQIRSDIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSI7</accession>
    <name>Q5CSI7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Dictyostelium gelation factor like filamin type immunoglobulin domain that is involved in binding actin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_2540</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628080.1">
        <property type="nucleotide sequence ID" value="XM_628080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSI7"/>
    <dbReference type="STRING" id="353152.Q5CSI7"/>
    <dbReference type="GeneID" id="3371696"/>
    <dbReference type="KEGG" id="cpv:cgd1_2540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2540"/>
    <dbReference type="InParanoid" id="Q5CSI7"/>
    <dbReference type="OMA" id="ENSWISC"/>
    <dbReference type="OrthoDB" id="342730at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="Filamin" evidence="1">
        <location>
            <begin position="162"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="600"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="1102"/>
            <end position="1146"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1188" mass="138817" checksum="2167F36ABFFF33EE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSK6</accession>
    <name>Q5CSK6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Integral membrane protein with 12 or more transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628061.1">
        <property type="nucleotide sequence ID" value="XM_628061.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3371725"/>
    <dbReference type="KEGG" id="cpv:cgd1_2300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2300"/>
    <dbReference type="InParanoid" id="Q5CSK6"/>
    <dbReference type="OMA" id="YHYHYHI"/>
    <dbReference type="OrthoDB" id="340227at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="39"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="165"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="265"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="790"/>
            <end position="811"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="823"/>
            <end position="843"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="855"/>
            <end position="874"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1000"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1082"/>
            <end position="1105"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1117"/>
            <end position="1136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1191"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1222"/>
            <end position="1242"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1566" mass="184188" checksum="0DD23266175C56EC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSK8</accession>
    <name>Q5CSK8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">40S ribosomal protein S26</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_2270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eS26 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628059.1">
        <property type="nucleotide sequence ID" value="XM_628059.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSK8"/>
    <dbReference type="FunCoup" id="Q5CSK8">
        <property type="interactions" value="321"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSK8"/>
    <dbReference type="GeneID" id="3371672"/>
    <dbReference type="KEGG" id="cpv:cgd1_2270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2270"/>
    <dbReference type="InParanoid" id="Q5CSK8"/>
    <dbReference type="OMA" id="KCYCVSC"/>
    <dbReference type="OrthoDB" id="10262653at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1740.20:FF:000003">
        <property type="entry name" value="40S ribosomal protein S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1740.20">
        <property type="entry name" value="Ribosomal protein S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000892">
        <property type="entry name" value="Ribosomal_eS26"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047864">
        <property type="entry name" value="Ribosomal_eS26_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038551">
        <property type="entry name" value="Ribosomal_eS26_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12538:SF0">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01283">
        <property type="entry name" value="Ribosomal_S26e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00733">
        <property type="entry name" value="RIBOSOMAL_S26E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU363128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="107" mass="12191" checksum="082C77487C5282EB" modified="2005-04-12" version="1">MPSKRRNNGRSKKGRGHVVAIRCSNCGRCVSKDKAIKRFVVRNIVDASSQRDIRDASVYSTYALPKLYNKMCYCVSCAIHSRTVRVRSVTDRKIRANPNSQRFKAQV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSL2</accession>
    <name>Q5CSL2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2210</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88385.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628055.1">
        <property type="nucleotide sequence ID" value="XM_628055.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSL2"/>
    <dbReference type="GeneID" id="3371675"/>
    <dbReference type="KEGG" id="cpv:cgd1_2210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2210"/>
    <dbReference type="InParanoid" id="Q5CSL2"/>
    <dbReference type="OrthoDB" id="338912at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="67"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88385.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="119" mass="14113" checksum="380F0BBD016AA565" modified="2005-04-12" version="1">MLLVDRISNLEEKVNEQNEAIKKIALYTLEILDENDRLWKHIMKDITMKHNRSSPQNINEHIFRFRSKTPPPLKEPNLPEKEQSFKVRRGTEKFNNDVFLSILTKEIGQKKVFPKNGKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSM8</accession>
    <name>Q5CSM8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane associated protein with over 9 transmembrane domains, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_2030</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88400.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628039.1">
        <property type="nucleotide sequence ID" value="XM_628039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSM8"/>
    <dbReference type="STRING" id="353152.Q5CSM8"/>
    <dbReference type="GeneID" id="3371651"/>
    <dbReference type="KEGG" id="cpv:cgd1_2030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2030"/>
    <dbReference type="InParanoid" id="Q5CSM8"/>
    <dbReference type="OMA" id="LWQSGKS"/>
    <dbReference type="OrthoDB" id="342890at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031464">
        <property type="term" value="C:Cul4A-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002781">
        <property type="entry name" value="TM_pro_TauE-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14255">
        <property type="entry name" value="CEREBLON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14255:SF3">
        <property type="entry name" value="SULFITE EXPORTER TAUE_SAFE FAMILY PROTEIN 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01925">
        <property type="entry name" value="TauE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0732">Signal</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="6">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254911" evidence="6">
        <location>
            <begin position="29"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="50"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="152"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="179"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="287"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="318"/>
            <end position="336"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="399"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="433"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="458"/>
            <end position="479"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="491"/>
            <end position="516"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88400.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="518" mass="57609" checksum="DE32E660CE61328F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSN9</accession>
    <name>Q5CSN9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">uracil phosphoribosyltransferase</fullName>
            <ecNumber evidence="4">2.4.2.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd1_1900</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Pyrimidine metabolism; UMP biosynthesis via salvage pathway; UMP from uracil: step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the UPRTase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.2.9" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88408.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628028.1">
        <property type="nucleotide sequence ID" value="XM_628028.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSN9"/>
    <dbReference type="STRING" id="353152.Q5CSN9"/>
    <dbReference type="GeneID" id="3371659"/>
    <dbReference type="KEGG" id="cpv:cgd1_1900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1900"/>
    <dbReference type="InParanoid" id="Q5CSN9"/>
    <dbReference type="OMA" id="KHKIGLM"/>
    <dbReference type="OrthoDB" id="106623at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004845">
        <property type="term" value="F:uracil phosphoribosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008655">
        <property type="term" value="P:pyrimidine-containing compound salvage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd06223">
        <property type="entry name" value="PRTases_typeI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2020:FF:000023">
        <property type="entry name" value="Probable uracil phosphoribosyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2020">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029057">
        <property type="entry name" value="PRTase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000836">
        <property type="entry name" value="PRTase_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14681">
        <property type="entry name" value="UPRTase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53271">
        <property type="entry name" value="PRTase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0021">Allosteric enzyme</keyword>
    <keyword evidence="6 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphoribosyltransferase" evidence="10">
        <location>
            <begin position="27"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00011894"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF14681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK88408.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="237" mass="26388" checksum="8D6454D237764819" modified="2007-04-03" version="1">MNFIVSPTEQELYSELSSKYPSLHICTQTPQLKGVMTILRDANTSKEDFVFYTDRICRIVLEHALNLLPYDYKEIKTPNGIEVKGIAFNTPICGVSLIGSGEAMENALRFVCRGCRIGKVLLNNSSENEFDNAISAAYVKLPEDVSERVVIVMSPVLGTGNSLCCLIEVLIKNNVKEKNIICMALLSSKLAIERVFSQFPEIRLVISSIDYNLDENMQVVPGVGNFGDRYFGIKCSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CST9</accession>
    <name>Q5CST9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">ABC-transporter, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_1360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88453.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627978.1">
        <property type="nucleotide sequence ID" value="XM_627978.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CST9"/>
    <dbReference type="GeneID" id="3371626"/>
    <dbReference type="KEGG" id="cpv:cgd1_1360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1360"/>
    <dbReference type="InParanoid" id="Q5CST9"/>
    <dbReference type="OrthoDB" id="6513042at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018838">
        <property type="entry name" value="ZGRF1-like_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10382">
        <property type="entry name" value="ZGRF1-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="5'-3' DNA helicase ZGRF1-like N-terminal" evidence="2">
        <location>
            <begin position="3"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="97"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF10382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88453.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="181" mass="20478" checksum="1490BE948A8A941B" modified="2005-04-12" version="1">MKKQFEVLYTRQKTQKTKTWHDGVVVIDNIKGINRISLYKTDENGYKGDIVESFSSHVQKINISKISFPGHLIELVNEEAIEEVELVVDEDLDANTSSVSKGIPNKTPPKSPENNDDNKNSLVKKNLIRPFKAPLVKVNMDICKSAQIKVPKKISKNIPLSKISSKQGFIKTLERIYTLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT02</accession>
    <name>Q5CT02_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_630</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88505.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627915.1">
        <property type="nucleotide sequence ID" value="XM_627915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT02"/>
    <dbReference type="GeneID" id="3371542"/>
    <dbReference type="KEGG" id="cpv:cgd1_630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_630"/>
    <dbReference type="InParanoid" id="Q5CT02"/>
    <dbReference type="OMA" id="SIHENEC"/>
    <dbReference type="OrthoDB" id="343138at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="22"/>
            <end position="55"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="178"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="133"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="190"/>
            <end position="201"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88505.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="309" mass="34044" checksum="6A24B4988C31A509" modified="2005-04-12" version="1">MVMKLELKLPGTDVGMRIAFGHLDENSTGSRTKASSSSSSSTSSPTLPSKQNSGAKIKVIKNDLEESECECDDCSGKAKTKEKAISHKDDDQYSVDMVTKVFASLMQCTASNINNSQFNQNNKLNQKSKGLKQVNSSKSNNKYASDSEDDPLARGILGKGCSSDFSVSQSLYPDDILVSYEPRRKKSPKSNKSPAKTKSAPLSSQVQQNTKDLKDVRIIPINKSTNAKILPNRNFKESKYDISCISVPTFCNKAKLISCCNARLIPQIPRCDLTRHEDENLMISVPSAIYPDNIILTLKNPKPKKNKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT32</accession>
    <name>Q5CT32_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Predicted secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_240</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88525.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627885.1">
        <property type="nucleotide sequence ID" value="XM_627885.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT32"/>
    <dbReference type="GeneID" id="3371425"/>
    <dbReference type="KEGG" id="cpv:cgd1_240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_240"/>
    <dbReference type="InParanoid" id="Q5CT32"/>
    <dbReference type="OMA" id="RRSICEM"/>
    <dbReference type="OrthoDB" id="337124at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88525.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="354" mass="40319" checksum="817706325EA96A2C" modified="2005-04-12" version="1">MSTAILGLIEGVYANRSNGTIDNKRKMCLEFSKELLDLDGTDFLKIITSLISDEEKSNKFIFTLAQALILCKGDKCDKRLLLIDRLLTGNRRVIEDVLSPIIAILTWIYLTRAFCTLSSIPKCHFDTNDSDHKALRPDYDGIEHILLRICSRNIDLLRSSSCNLCLHEDDLNSSVILGTNKLKLFKQTKAERKHRFVDFIEKFDGDSYSNFPTSHKDQTTLVQICISLIHQLNFNGTITFIWIMLGLCSSLSNQELIPIDLFSINFETRDISPNNSKIRINIEDDTLITICKVVGKCLFSLSSTKFNSNIKKLIYKKIRITLNKVQKRSICEVMPNSSSFISSYIVLIEKILNS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTH6</accession>
    <name>Q5CTH6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626493.1">
        <property type="nucleotide sequence ID" value="XM_626493.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTH6"/>
    <dbReference type="GeneID" id="3373459"/>
    <dbReference type="KEGG" id="cpv:cgd2_2980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2980"/>
    <dbReference type="InParanoid" id="Q5CTH6"/>
    <dbReference type="OMA" id="HIHIISG"/>
    <dbReference type="OrthoDB" id="340338at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1100" mass="124978" checksum="0FE8813CE2426234" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU86</accession>
    <name>Q5CU86_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">AP complex subunit sigma</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_3810</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the adaptor complexes small subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89244.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626928.1">
        <property type="nucleotide sequence ID" value="XM_626928.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU86"/>
    <dbReference type="STRING" id="353152.Q5CU86"/>
    <dbReference type="GeneID" id="3373929"/>
    <dbReference type="KEGG" id="cpv:cgd3_3810"/>
    <dbReference type="InParanoid" id="Q5CU86"/>
    <dbReference type="OMA" id="WYNSENI"/>
    <dbReference type="OrthoDB" id="371463at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.450.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016635">
        <property type="entry name" value="AP_complex_ssu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022775">
        <property type="entry name" value="AP_mu_sigma_su"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011012">
        <property type="entry name" value="Longin-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11753">
        <property type="entry name" value="ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01217">
        <property type="entry name" value="Clat_adaptor_s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015588">
        <property type="entry name" value="AP_complex_sigma"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64356">
        <property type="entry name" value="SNARE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="AP complex mu/sigma subunit" evidence="7">
        <location>
            <begin position="4"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006972"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015588"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89244.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="139" mass="16186" checksum="448155F2D06EF1AD" modified="2005-04-12" version="1" fragment="single">TKKMIHFFIIQNLSGSTIFSKWYNSENIENRNRLQEAIKERLSCLEEKHLSYFTLGDTRIIFKKYKKIFMITGVDFDENILLMLATIQLINEAFGSHSRDISDVDVIYNNKKYMKIIDEIILGGEVIGTSMKNIKGLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUC0</accession>
    <name>Q5CUC0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Amine oxidase</fullName>
            <ecNumber evidence="3">1.4.3.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_3430</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <cofactor evidence="3">
            <name>Cu cation</name>
            <dbReference type="ChEBI" id="CHEBI:23378"/>
        </cofactor>
        <text evidence="3">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>L-topaquinone</name>
            <dbReference type="ChEBI" id="CHEBI:79027"/>
        </cofactor>
        <text evidence="2">Contains 1 topaquinone per subunit.</text>
    </comment>
    <comment type="PTM">
        <text evidence="2 3">Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.</text>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the copper/topaquinone oxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="1.4.3.-" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626894.1">
        <property type="nucleotide sequence ID" value="XM_626894.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CUC0"/>
    <dbReference type="STRING" id="353152.Q5CUC0"/>
    <dbReference type="GeneID" id="3374120"/>
    <dbReference type="KEGG" id="cpv:cgd3_3430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3430"/>
    <dbReference type="InParanoid" id="Q5CUC0"/>
    <dbReference type="OMA" id="PSMDLHN"/>
    <dbReference type="OrthoDB" id="5379943at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005507">
        <property type="term" value="F:copper ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008131">
        <property type="term" value="F:primary methylamine oxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048038">
        <property type="term" value="F:quinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009308">
        <property type="term" value="P:amine metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd06263">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.200">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.98.20">
        <property type="entry name" value="Copper amine oxidase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013320">
        <property type="entry name" value="ConA-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049947">
        <property type="entry name" value="Cu_Am_Ox_Cu-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049948">
        <property type="entry name" value="Cu_Am_ox_TPQ-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000269">
        <property type="entry name" value="Cu_amine_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015798">
        <property type="entry name" value="Cu_amine_oxidase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036460">
        <property type="entry name" value="Cu_amine_oxidase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000998">
        <property type="entry name" value="MAM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638:SF20">
        <property type="entry name" value="AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10638">
        <property type="entry name" value="COPPER AMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01179">
        <property type="entry name" value="Cu_amine_oxid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00629">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00137">
        <property type="entry name" value="MAM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49998">
        <property type="entry name" value="Amine oxidase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49899">
        <property type="entry name" value="Concanavalin A-like lectins/glucanases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01164">
        <property type="entry name" value="COPPER_AMINE_OXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01165">
        <property type="entry name" value="COPPER_AMINE_OXID_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50060">
        <property type="entry name" value="MAM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0186">Copper</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <keyword evidence="1 3" id="KW-0801">TPQ</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253859" description="Amine oxidase" evidence="5">
        <location>
            <begin position="22"/>
            <end position="1769"/>
        </location>
    </feature>
    <feature type="domain" description="MAM" evidence="6">
        <location>
            <begin position="286"/>
            <end position="476"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1182"/>
            <end position="1207"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="1">
        <location>
            <position position="1417"/>
        </location>
    </feature>
    <feature type="active site" description="Schiff-base intermediate with substrate; via topaquinone" evidence="1">
        <location>
            <position position="1489"/>
        </location>
    </feature>
    <feature type="modified residue" description="2',4',5'-topaquinone" evidence="2">
        <location>
            <position position="1489"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-50"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR600269-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU000672"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50060"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1769" mass="199341" checksum="AB34E3B4A675325A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUN0</accession>
    <name>Q5CUN0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SprT like metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_2160</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626784.1">
        <property type="nucleotide sequence ID" value="XM_626784.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUN0"/>
    <dbReference type="STRING" id="353152.Q5CUN0"/>
    <dbReference type="GeneID" id="3373784"/>
    <dbReference type="KEGG" id="cpv:cgd3_2160"/>
    <dbReference type="InParanoid" id="Q5CUN0"/>
    <dbReference type="OMA" id="IWRCNGP"/>
    <dbReference type="OrthoDB" id="5236983at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044245">
        <property type="entry name" value="Spartan"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006640">
        <property type="entry name" value="SprT-like_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055220">
        <property type="entry name" value="SPRTN_ZBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21220:SF0">
        <property type="entry name" value="DNA-DEPENDENT METALLOPROTEASE SPRTN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10263">
        <property type="entry name" value="SprT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22934">
        <property type="entry name" value="SPRTN_ZBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00731">
        <property type="entry name" value="SprT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0645">Protease</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SprT-like" evidence="3">
        <location>
            <begin position="26"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="233" mass="27330" checksum="B347C6F77A8DF75B" modified="2005-04-12" version="1" fragment="single">LLNKVLQKKIINQFNSRDEDLASGFPDIHELLLEYNDLYFFGSLGSVIIRWSNRMTLCAGKCTYETGGRCIVSLSEPLLKYRSVKELRETILHELIHAYLFVTSNDRDRNFHGKEFCFHMNRINKMSGLNITIYHNFHDELNYYRRYIWRCDGVCRNHPPYYGYVRRSINRKPGPADSWWNFHRKTCGGCFVKEAKTLPQINNLESLGTRPNGQTSSPNMHQDDILEIIEISD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUN4</accession>
    <name>Q5CUN4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myosin fused to 3 IQ motifs (That interact with calmodulin) and Rcc1 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd3_2120</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="9" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="9">Iowa type II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89094.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626780.1">
        <property type="nucleotide sequence ID" value="XM_626780.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUN4"/>
    <dbReference type="GeneID" id="3374043"/>
    <dbReference type="KEGG" id="cpv:cgd3_2120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2120"/>
    <dbReference type="InParanoid" id="Q5CUN4"/>
    <dbReference type="OMA" id="ENESAQY"/>
    <dbReference type="OrthoDB" id="16281at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098858">
        <property type="term" value="C:actin-based cell projection"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23767">
        <property type="entry name" value="IQCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd23766">
        <property type="entry name" value="IQCG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.190">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000048">
        <property type="entry name" value="IQ_motif_EF-hand-BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00612">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00415">
        <property type="entry name" value="RCC1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00015">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50096">
        <property type="entry name" value="IQ"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00626">
        <property type="entry name" value="RCC1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3" id="KW-0518">Myosin</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="99"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="1436"/>
            <end position="1513"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="1514"/>
            <end position="1566"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="1664"/>
            <end position="1743"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1619"/>
            <end position="1641"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1624"/>
            <end position="1641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89094.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2083" mass="240061" checksum="F4E494E37E050F2A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUQ3</accession>
    <name>Q5CUQ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein with 2 transmembrane domains near N-terminus, possible ArgA, N-acetylglutamate synthase and related acetyltransferase, camello or GNAT</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_1900</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89107.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626761.1">
        <property type="nucleotide sequence ID" value="XM_626761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUQ3"/>
    <dbReference type="FunCoup" id="Q5CUQ3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUQ3"/>
    <dbReference type="GeneID" id="3374150"/>
    <dbReference type="KEGG" id="cpv:cgd3_1900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1900"/>
    <dbReference type="InParanoid" id="Q5CUQ3"/>
    <dbReference type="OMA" id="RGDLIIW"/>
    <dbReference type="OrthoDB" id="41532at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008080">
        <property type="term" value="F:N-acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050769">
        <property type="entry name" value="NAT_camello-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947">
        <property type="entry name" value="GNAT FAMILY N-ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13947:SF37">
        <property type="entry name" value="LD18367P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="41"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="68"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="173"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="131"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="144"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89107.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="291" mass="33306" checksum="0F1EA276B9952F9A" modified="2005-04-12" version="1">MTGNNPYGGYDLVIREFDPSDSDGVRRVCFKHFRSLTFPSVFFYLSQHLADMIALLVIGKVFMDFKQLISMLVLFCVYLTGRSIWEVETYIRNCCTDLRNVHELYMISPGYHFWVAELVKRRNSIRKRRSMVLGSGGGSNSRAEGLEQNDHASKSIECEDTPSNRMEGGESILVGCVGLAPYRDDPKIGRLVRLVVGVESRRMRIGTRLLAQMENFAKDYGYKEIHLYTNNLSTSPIKFISQHGYQLVQVISRGLMRGDLLLWRKSFEKSSSDNSYLNNERNSIGERVILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUQ8</accession>
    <name>Q5CUQ8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Casein kinase II subunit beta</fullName>
            <shortName evidence="2">CK II beta</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_1850</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="2">Tetramer of two alpha and two beta subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the casein kinase 2 subunit beta family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89111.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626756.1">
        <property type="nucleotide sequence ID" value="XM_626756.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUQ8"/>
    <dbReference type="SMR" id="Q5CUQ8"/>
    <dbReference type="FunCoup" id="Q5CUQ8">
        <property type="interactions" value="32"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUQ8"/>
    <dbReference type="GeneID" id="3374154"/>
    <dbReference type="KEGG" id="cpv:cgd3_1850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1850"/>
    <dbReference type="InParanoid" id="Q5CUQ8"/>
    <dbReference type="OMA" id="FGFSVYH"/>
    <dbReference type="OrthoDB" id="3971593at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005956">
        <property type="term" value="C:protein kinase CK2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1820.10:FF:000005">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.20:FF:000001">
        <property type="entry name" value="Casein kinase II subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1820.10">
        <property type="entry name" value="protein kinase ck2 holoenzyme, chain C, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016149">
        <property type="entry name" value="Casein_kin_II_reg-sub_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035991">
        <property type="entry name" value="Casein_kinase_II_beta-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000704">
        <property type="entry name" value="Casein_kinase_II_reg-sub"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11740:SF0">
        <property type="entry name" value="CASEIN KINASE II SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01214">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00472">
        <property type="entry name" value="CASNKINASEII"/>
    </dbReference>
    <dbReference type="SMART" id="SM01085">
        <property type="entry name" value="CK_II_beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57798">
        <property type="entry name" value="Casein kinase II beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01101">
        <property type="entry name" value="CK2_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="268"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="291"/>
            <end position="306"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU361268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89111.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="338" mass="38563" checksum="73CC15BA5E8121FC" modified="2005-04-12" version="1">MISLINEGDTSLPQWNNMMGLNSDSDESENGWVHWYCGLREHYFFIVIPNEYTRDAFNLYGLRQYFPKNYDSLIELILSSNIPDEDDLADPALQDLHREAGELYGLIHARYITTPRGLQIMKHKYDKGCFGKCPRVLCNGYKVLPVGITNELRSRRVRVYCPNCQEAYDPRNVNLIDIDGAFFGTSFPHIFLQVYPEYISTSCPEPYYPKIFGFRVSDKLSIIERKGINGEYGKRAQVEMFKARPSSVQHIEKPQLLNIGTGKLQNSMVDGSNVNSSSNQDNLNSRNSEYNSTASSKTIKSSNTSNANVLAYRPEDINMNQMPYNLNSASRSCSYSRQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUQ9</accession>
    <name>Q5CUQ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Large uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_1840</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89112.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626755.1">
        <property type="nucleotide sequence ID" value="XM_626755.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3374155"/>
    <dbReference type="KEGG" id="cpv:cgd3_1840"/>
    <dbReference type="InParanoid" id="Q5CUQ9"/>
    <dbReference type="OMA" id="LENAFCT"/>
    <dbReference type="OrthoDB" id="338970at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89112.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1757" mass="200634" checksum="2CF3FB12B65776AC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV18</accession>
    <name>Q5CV18_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89200.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626646.1">
        <property type="nucleotide sequence ID" value="XM_626646.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV18"/>
    <dbReference type="GeneID" id="3373789"/>
    <dbReference type="KEGG" id="cpv:cgd3_610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_610"/>
    <dbReference type="InParanoid" id="Q5CV18"/>
    <dbReference type="OMA" id="WSICALP"/>
    <dbReference type="OrthoDB" id="340976at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="46"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="158"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="194"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="251"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89200.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="363" mass="41662" checksum="6CA13721B9C01320" modified="2005-04-12" version="1">MEQNSIVPYHNGRNYPEYGQLTNYYPNNTNNNGNDSKSAPYEIPGCPVFSVFIATVVGILWLFFALTLPAYHYARVVFPIDNYIDLNFGLWTVHVSSNCDSFVSFDANKKMCRFIVSRMDNLSISDATNFICSLEAGTLQLLNLGCNKFHLLRIGSSVIMTMFILSIILLFFAAIFLLTFWFCYRTRRVRQSIFMLHFISALTCVLGIVGYLLVGGLTIQPFRDSSMFGIGSSMFARLFFVDISRTFDLSTGFAFAAFGMIWIVLLPLWSVCALPSDICVDAIEVIEDTTYEEEELKKLLGYSGLFGQNYGNEQSAANNSYYYQNNQNQNYYNHQYPQYYQGQQNHNPYGQQYPYYNQQYRGY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV67</accession>
    <name>Q5CV67_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="16">U2AG splicing factor U2AF U2snRNP auxilliary factor small subunit CCCh+RRM+CCCh-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd8_5240</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89737.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627402.1">
        <property type="nucleotide sequence ID" value="XM_627402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV67"/>
    <dbReference type="FunCoup" id="Q5CV67">
        <property type="interactions" value="345"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV67"/>
    <dbReference type="GeneID" id="3374664"/>
    <dbReference type="KEGG" id="cpv:cgd8_5240"/>
    <dbReference type="InParanoid" id="Q5CV67"/>
    <dbReference type="OMA" id="MIDTRQA"/>
    <dbReference type="OrthoDB" id="423462at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0089701">
        <property type="term" value="C:U2AF complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12287">
        <property type="entry name" value="RRM_U2AF35_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000122">
        <property type="entry name" value="Splicing factor U2AF small subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009145">
        <property type="entry name" value="U2AF_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12620">
        <property type="entry name" value="U2 SNRNP AUXILIARY FACTOR, SMALL SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01848">
        <property type="entry name" value="U2AUXFACTOR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <keyword evidence="7 11" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="5 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="14">
        <location>
            <begin position="90"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="15">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="19"/>
            <end position="47"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="12">
        <location>
            <begin position="156"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="207"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="215"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK89737.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="256" mass="29697" checksum="93D9D29B11A96E95" modified="2005-04-12" version="1" fragment="single">DVNQNGQMAEHLARILGTEEDRVNCPFYWKIGACRHGDQCSRNHYKPTSSPTVIIRHIYENSPVALAIAEGQEVSDKLADEESDKVEVFYEEMFKELSKYGEILELLICDNIGDHMIGNVYIRFSTEEYAKTALANLRGKMYAGKPINIELSPVSDFKEARCRQYIDGCCNRGGYCNFMHIKHVPRCVKDKIFDQMYSEHPEYLHRKTNSCGKSSARDDGKGSESSRPRKFQRQSSEERRLMIESWNKRRENNSWY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV75</accession>
    <name>Q5CV75_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Ssd1p/F48E8.6-like RNAseII</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_5150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627394.1">
        <property type="nucleotide sequence ID" value="XM_627394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV75"/>
    <dbReference type="STRING" id="353152.Q5CV75"/>
    <dbReference type="GeneID" id="3374232"/>
    <dbReference type="KEGG" id="cpv:cgd8_5150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5150"/>
    <dbReference type="InParanoid" id="Q5CV75"/>
    <dbReference type="OMA" id="HIEWNES"/>
    <dbReference type="OrthoDB" id="372421at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000175">
        <property type="term" value="F:3'-5'-RNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006402">
        <property type="term" value="P:mRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001900">
        <property type="entry name" value="RNase_II/R"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050180">
        <property type="entry name" value="RNR_Ribonuclease"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355:SF9">
        <property type="entry name" value="DIS3-LIKE EXONUCLEASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23355">
        <property type="entry name" value="RIBONUCLEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00773">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00955">
        <property type="entry name" value="RNB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RNB" evidence="1">
        <location>
            <begin position="381"/>
            <end position="805"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="SMART" id="SM00955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1031" mass="119232" checksum="399FEFBB1155B793" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV85</accession>
    <name>Q5CV85_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Starch binding domain containing protein, possible plant origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_5020</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627384.1">
        <property type="nucleotide sequence ID" value="XM_627384.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV85"/>
    <dbReference type="CAZy" id="CBM20">
        <property type="family name" value="Carbohydrate-Binding Module Family 20"/>
    </dbReference>
    <dbReference type="GeneID" id="3374207"/>
    <dbReference type="KEGG" id="cpv:cgd8_5020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5020"/>
    <dbReference type="InParanoid" id="Q5CV85"/>
    <dbReference type="OMA" id="YVISENY"/>
    <dbReference type="OrthoDB" id="408870at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001070">
        <property type="term" value="F:starch binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05467">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013784">
        <property type="entry name" value="Carb-bd-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002044">
        <property type="entry name" value="CBM20"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15048">
        <property type="entry name" value="STARCH-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15048:SF0">
        <property type="entry name" value="STARCH-BINDING DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00686">
        <property type="entry name" value="CBM_20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01065">
        <property type="entry name" value="CBM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49452">
        <property type="entry name" value="Starch-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51166">
        <property type="entry name" value="CBM20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBM20" evidence="2">
        <location>
            <begin position="47"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="6"/>
            <end position="46"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="158" mass="18316" checksum="2A74CC92B38B4B8A" modified="2005-04-12" version="1">MEPSRKENTEETLDENRLRIRKLYEKKLHDRKLRIYEEALEEAIRREKMNVSVIVKFGVKFETKFGQELKVVGNIAELGNWNVDNGLTMKWTEGSFWTANVKIVPNSKIENIEYKYVLTNSSSKAHVWEPGKNHSVQISSDTLRELQLTDAWGGGGLY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV87</accession>
    <name>Q5CV87_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_5000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89627.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627382.1">
        <property type="nucleotide sequence ID" value="XM_627382.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV87"/>
    <dbReference type="STRING" id="353152.Q5CV87"/>
    <dbReference type="GeneID" id="3374204"/>
    <dbReference type="KEGG" id="cpv:cgd8_5000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5000"/>
    <dbReference type="InParanoid" id="Q5CV87"/>
    <dbReference type="OMA" id="EDWWDEG"/>
    <dbReference type="OrthoDB" id="30195at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052414">
        <property type="entry name" value="U3_snoRNA-assoc_WDR"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44267:SF1">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 43"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="200"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="200"/>
            <end position="256"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="273"/>
            <end position="290"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89627.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="297" mass="34257" checksum="EC50BBFF0039335E" modified="2005-04-12" version="1">MEDHSEQSVLHSPKKMRKTGINEVNKVTGGTVCDEHEFIGTNNQSVTIVNILRQGIQSKDKNMLENALSHNDIKIIRGSVSQISDGNCLELFEEIMNRIEDNPMKLLELSNWISVLLEGIARQVVAFKGDTDRILLILNQMERLNEIISMRLSYNQDLISLQSTLDIFQHIIEENKLITEMCNKISSESNNALITYQFEADQENDENDSFDNYEDEDEDDIDIDHEDENEDDDDEDEDDDNDEVDDNGNEDEDDEDYNSKIRKVRKTKGVKDESDENDSDSEENDDDNEYEERSNSE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVA0</accession>
    <name>Q5CVA0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">SUN domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_4850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89618.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627369.1">
        <property type="nucleotide sequence ID" value="XM_627369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVA0"/>
    <dbReference type="STRING" id="353152.Q5CVA0"/>
    <dbReference type="GeneID" id="3374374"/>
    <dbReference type="KEGG" id="cpv:cgd8_4850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4850"/>
    <dbReference type="InParanoid" id="Q5CVA0"/>
    <dbReference type="OMA" id="TICNTEV"/>
    <dbReference type="OrthoDB" id="266334at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034975">
        <property type="term" value="P:protein folding in endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045120">
        <property type="entry name" value="Suco/Slp1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012919">
        <property type="entry name" value="SUN_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953">
        <property type="entry name" value="MEMBRANE PROTEIN CH1 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12953:SF0">
        <property type="entry name" value="SUN DOMAIN-CONTAINING OSSIFICATION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07738">
        <property type="entry name" value="Sad1_UNC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51469">
        <property type="entry name" value="SUN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="962"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="domain" description="SUN" evidence="7">
        <location>
            <begin position="462"/>
            <end position="706"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1138"/>
            <end position="1158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89618.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1158" mass="133545" checksum="3F48A7EE0569C778" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVE0</accession>
    <name>Q5CVE0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Cgd8_4410 protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89579.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627329.1">
        <property type="nucleotide sequence ID" value="XM_627329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVE0"/>
    <dbReference type="GeneID" id="3374534"/>
    <dbReference type="KEGG" id="cpv:cgd8_4410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4410"/>
    <dbReference type="InParanoid" id="Q5CVE0"/>
    <dbReference type="OMA" id="CYSSSIQ"/>
    <dbReference type="OrthoDB" id="338461at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="45"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89579.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="546" mass="63699" checksum="1860423A0B2EF684" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVK2</accession>
    <name>Q5CVK2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627267.1">
        <property type="nucleotide sequence ID" value="XM_627267.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVK2"/>
    <dbReference type="GeneID" id="3374281"/>
    <dbReference type="KEGG" id="cpv:cgd8_3750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3750"/>
    <dbReference type="InParanoid" id="Q5CVK2"/>
    <dbReference type="OMA" id="AIESEHY"/>
    <dbReference type="OrthoDB" id="342245at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="105"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="143"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="308"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="154"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="308"/>
            <end position="332"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="342"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="401"/>
            <end position="415"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="435" mass="48365" checksum="F36F0642D07D6926" modified="2005-04-12" version="1">MMVGLLNRQEDVSPNLAFGSVPITGPVFDEELLRWIAEAEYLGVSRETAILIATKRRALNLNKSGGSLVVDTQSKGINLASEKSLSHSNNPLQLPITVIGAEDDEHNKQNSKANSPPGSDHGSCSEGYIYEENHLNLGFQAEQQQKPSVALKNSSSQTSSTQETITTKFDGLLDQVINTTIAHINFDESKRKKKKYKRRKKFSQRNILSTTCNSDNASNSISSQSINTHLLKTIVEKDSNLKMILSDDNNSSVDTTMGVVNSGTNQVDRLTTHCSGLDAVVAAHSDNPFNNNDRNYNIKVRRKKRFYQRNNNVGSSSNKHNPTQNTQVTSALNDFPEPSKINLKHTKRNFHRNRKSLGLHPNPISEKATDSSNNAIALSNPELRNLTQQPKSNGGYGRRANNSERGRIRPRKSEAVEHVREQLRIAFRSRGVLEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVL4</accession>
    <name>Q5CVL4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627255.1">
        <property type="nucleotide sequence ID" value="XM_627255.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVL4"/>
    <dbReference type="GeneID" id="3374307"/>
    <dbReference type="KEGG" id="cpv:cgd8_3620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3620"/>
    <dbReference type="InParanoid" id="Q5CVL4"/>
    <dbReference type="OrthoDB" id="10256182at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="38"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="65"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="97"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="138"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="183"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="222"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="250" mass="28754" checksum="88F75FD7954129FA" modified="2005-04-12" version="1">MMEIITVDSLQENKYIYSGSESTKNNSFESFCSRFFKLNYGIIILSVFSMLVTIFGSLFESIIKMYCFMMVNRLVCTAMIFSFLRHIWNFDKSSIKIIFSLHLINQFNYLGVSIVAISTKVPSISTASILNSFNIMNVFSTICFASIFIMEIVNLIYVYNLFFQAQKNLIILKQEMNNNNIKLNLCTYIIFGYNLITDCIYIMTSIIAYAKFTLFHGHYIEISLSSISGICILIFATGLILSISIFNYLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVN4</accession>
    <name>Q5CVN4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Mitochondrial import inner membrane translocase subunit TIM50</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_3400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.</text>
    </comment>
    <comment type="subunit">
        <text evidence="1">Component of the TIM23 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the TIM50 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89508.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627235.1">
        <property type="nucleotide sequence ID" value="XM_627235.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVN4"/>
    <dbReference type="STRING" id="353152.Q5CVN4"/>
    <dbReference type="DNASU" id="3374301"/>
    <dbReference type="GeneID" id="3374301"/>
    <dbReference type="KEGG" id="cpv:cgd8_3400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3400"/>
    <dbReference type="InParanoid" id="Q5CVN4"/>
    <dbReference type="OMA" id="FFGIMNQ"/>
    <dbReference type="OrthoDB" id="445750at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005744">
        <property type="term" value="C:TIM23 mitochondrial import inner membrane translocase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0809">Transit peptide</keyword>
    <keyword evidence="1" id="KW-0811">Translocation</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="144"/>
            <end position="285"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365079"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89508.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="333" mass="39456" checksum="124573A3E9A878C1" modified="2005-04-12" version="1">MLLNTIVKCFKRHILISPQYSTFLVKNLDIRFLYSRFHYNLQRKLNRDKYFILLNNNFRNFHNLNQSAPKLNLYRIITKNLLGIGITMYFGYFVAKKRPIRLSDICNKFERFNDWSYDLLQNQINRFVPPDDEPLLPDFEQLGYPRNLPTLVLGLRGLICEITHSKKNGWGIVKRPGVDKFFNILKNYYEIVIWSDESFPIPHEVLEKWNLPIIGILNKNHFSKINGKLFKNLSRLGRNLNRVILVDNESYSANIQYDNSIVLPIFKGDPYDNELNSIIDLLKAAALQPGDIREYLKRFRCNDTNIGDQFNEYRKTVSEKSELRRKFGKFFLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVP4</accession>
    <name>Q5CVP4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd8_3300</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-13 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627225.1">
        <property type="nucleotide sequence ID" value="XM_627225.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVP4"/>
    <dbReference type="SMR" id="Q5CVP4"/>
    <dbReference type="STRING" id="353152.Q5CVP4"/>
    <dbReference type="GeneID" id="3374251"/>
    <dbReference type="KEGG" id="cpv:cgd8_3300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3300"/>
    <dbReference type="InParanoid" id="Q5CVP4"/>
    <dbReference type="OMA" id="VMIANIC"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007019">
        <property type="term" value="P:microtubule depolymerization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01367">
        <property type="entry name" value="KISc_KIF2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.850.10:FF:000012">
        <property type="entry name" value="Kinesin-like protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971:SF8">
        <property type="entry name" value="KINESIN-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47971">
        <property type="entry name" value="KINESIN-RELATED PROTEIN 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 9 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 10" id="KW-0493">Microtubule</keyword>
    <keyword evidence="6 9 10" id="KW-0505">Motor protein</keyword>
    <keyword evidence="4 9 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="13">
        <location>
            <begin position="29"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="394"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="573"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="432"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="121"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00061030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK89501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="610" mass="69881" checksum="8D7C7BF52D67624E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVP9</accession>
    <name>Q5CVP9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apicomplexan specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3240</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89497.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627220.1">
        <property type="nucleotide sequence ID" value="XM_627220.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVP9"/>
    <dbReference type="GeneID" id="3374247"/>
    <dbReference type="KEGG" id="cpv:cgd8_3240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3240"/>
    <dbReference type="InParanoid" id="Q5CVP9"/>
    <dbReference type="OMA" id="FGYQFDY"/>
    <dbReference type="OrthoDB" id="343184at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="544"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="548"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89497.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="749" mass="85559" checksum="7EABBFE94FAD5155" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVW5</accession>
    <name>Q5CVW5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Apicomplexan specific coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_2540</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89443.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627154.1">
        <property type="nucleotide sequence ID" value="XM_627154.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVW5"/>
    <dbReference type="GeneID" id="3374572"/>
    <dbReference type="KEGG" id="cpv:cgd8_2540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2540"/>
    <dbReference type="InParanoid" id="Q5CVW5"/>
    <dbReference type="OMA" id="IVTKYDP"/>
    <dbReference type="OrthoDB" id="361055at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89443.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="265" mass="29680" checksum="1BFBD2EA241132E9" modified="2005-04-12" version="1">MDGNSSSTKLSGSGLPPMSFSPEIQGFIVTKFDPLLSIVKELNDHLQSSDKERLRLEYRVSRIERTLESLIKIVTDLGYKLPEEDEFEKNIPELKNELSLLLSGEESVTAPWLFSVQSGTPISSLQVLLEFSQSNTEVLLADTWRREEDMWIGFLDDLPDEFSTRRPESLSLVDLRRAARRALLEVIRGELLLVIRNVPGKQEVPHNPLPVTLVAILAAAFSEAWERVESSDPNSLGRLALVLEGDNIGSRLRAGKKKFAIEALN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVX4</accession>
    <name>Q5CVX4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ser/Thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_2440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89434.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627145.1">
        <property type="nucleotide sequence ID" value="XM_627145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVX4"/>
    <dbReference type="FunCoup" id="Q5CVX4">
        <property type="interactions" value="459"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVX4"/>
    <dbReference type="GeneID" id="3374270"/>
    <dbReference type="KEGG" id="cpv:cgd8_2440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2440"/>
    <dbReference type="InParanoid" id="Q5CVX4"/>
    <dbReference type="OMA" id="KTNTIIC"/>
    <dbReference type="OrthoDB" id="447103at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051177">
        <property type="entry name" value="CIK-Related_Protein"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984:SF3">
        <property type="entry name" value="N-TERMINAL KINASE-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12984">
        <property type="entry name" value="SCY1-RELATED S/T PROTEIN KINASE-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="2">
        <location>
            <begin position="15"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="678"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="720"/>
            <end position="739"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="805"/>
            <end position="825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="678"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="689"/>
            <end position="707"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="720"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="805"/>
            <end position="823"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89434.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="913" mass="103407" checksum="BE4C669FF2ED5411" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW02</accession>
    <name>Q5CW02_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627117.1">
        <property type="nucleotide sequence ID" value="XM_627117.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW02"/>
    <dbReference type="GeneID" id="3374556"/>
    <dbReference type="KEGG" id="cpv:cgd8_2140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2140"/>
    <dbReference type="InParanoid" id="Q5CW02"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="61"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="103" mass="11177" checksum="D280AC27856373F9" modified="2005-04-12" version="1">MDASVILSRLSLYCSMLCLIIFSVSSSGIIGSCDSVGDDVPVNTLFEFVTSLLELEFEANFLLILPALTASSYPSLILFKDFITSKVNFLSLLSNKDGLLKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW03</accession>
    <name>Q5CW03_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CID domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89410.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627116.1">
        <property type="nucleotide sequence ID" value="XM_627116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW03"/>
    <dbReference type="GeneID" id="3374555"/>
    <dbReference type="KEGG" id="cpv:cgd8_2130"/>
    <dbReference type="InParanoid" id="Q5CW03"/>
    <dbReference type="OrthoDB" id="338650at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006569">
        <property type="entry name" value="CID_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008942">
        <property type="entry name" value="ENTH_VHS"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04818">
        <property type="entry name" value="CID"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CID" evidence="1">
        <location>
            <begin position="21"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF04818"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89410.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="152" mass="18056" checksum="19DA79AF8D2D583B" modified="2005-04-12" version="1">MRDNKGREENYPVVPTDRILRNFKQLSHHNDSISQMASWLSFYRSSGEQLCSLFGEAFVDKSLREEERLAIFYVFHEMVTRAITNDDESRKFFLIGYEQFLLTAAPIISRLTFEQRSPYLQVVRLWQSHQRFPQNVCERLRLLFNSQSGKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW81</accession>
    <name>Q5CW81_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_1310</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627038.1">
        <property type="nucleotide sequence ID" value="XM_627038.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW81"/>
    <dbReference type="GeneID" id="3374267"/>
    <dbReference type="KEGG" id="cpv:cgd8_1310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1310"/>
    <dbReference type="InParanoid" id="Q5CW81"/>
    <dbReference type="OMA" id="CEICKSM"/>
    <dbReference type="OrthoDB" id="337897at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="464" mass="54796" checksum="E167D150411BC36C" modified="2005-04-12" version="1">MKSYTRDNVVKHMSEIFSDIPDVIIGDIFDYLVKENLKLCKQLSSCDKEYSYENEMNNIINELYEKLSEISIKEGYNDCCQFDFQESSKNSGEFDKQYQDLNNNIDFNRYLNLNFYFNQIQNDELDTYMKDFLKQNNKLSYLSVCTQNQQTSSNPINPLKSSNNNNNSIQRDILKLGKKPWNIFEIQSELIHYEMNIFSSILTKIFNSPRLFKVKEGKNKNWPPEGPGNESNSIQIKDMKLSSRSKESLKEIEILQNQIQDLNLSLKLKYSELNNILNNSNISEYKAIKSQEFKHKINSIKIDRLNLQKRLFNLVFNSQNNYFIDYFSTKSNHNSQVVVDLHNFNRNETINLVIFTIIMIIKYKFQANMEEILSKNIHHFKITQQELELSQKSFKGKFVDIYFCVGIGNHNNFHGNIDSPKLASLIRRISFALNLIWRFGSIGFIIVRIQDNPNWYKFFQEFLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW90</accession>
    <name>Q5CW90_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein with threonine repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627029.1">
        <property type="nucleotide sequence ID" value="XM_627029.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW90"/>
    <dbReference type="STRING" id="353152.Q5CW90"/>
    <dbReference type="GeneID" id="3374262"/>
    <dbReference type="KEGG" id="cpv:cgd8_1220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1220"/>
    <dbReference type="InParanoid" id="Q5CW90"/>
    <dbReference type="OrthoDB" id="344193at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01217">
        <property type="entry name" value="PRICHEXTENSN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="227"/>
            <end position="342"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="389"/>
            <end position="461"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="483"/>
            <end position="533"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="227"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="248"/>
            <end position="260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="262"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="303"/>
            <end position="326"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="796" mass="88538" checksum="D1E0F9E2EA6DDFFF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWC2</accession>
    <name>Q5CWC2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">CobW/nitrile hydratase activator like P-loop ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89666.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626997.1">
        <property type="nucleotide sequence ID" value="XM_626997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWC2"/>
    <dbReference type="FunCoup" id="Q5CWC2">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWC2"/>
    <dbReference type="GeneID" id="3374430"/>
    <dbReference type="KEGG" id="cpv:cgd8_890"/>
    <dbReference type="InParanoid" id="Q5CWC2"/>
    <dbReference type="OMA" id="HSQGFET"/>
    <dbReference type="OrthoDB" id="258627at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03112">
        <property type="entry name" value="CobW-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1220.10">
        <property type="entry name" value="CobW-like, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036627">
        <property type="entry name" value="CobW-likC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003495">
        <property type="entry name" value="CobW/HypB/UreG_nucleotide-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051316">
        <property type="entry name" value="Zinc-reg_GTPase_activator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748">
        <property type="entry name" value="COBW-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13748:SF31">
        <property type="entry name" value="ZINC-REGULATED GTPASE METALLOPROTEIN ACTIVATOR 1A-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02492">
        <property type="entry name" value="cobW"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CobW/HypB/UreG nucleotide-binding" evidence="1">
        <location>
            <begin position="17"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF02492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89666.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="423" mass="47978" checksum="F373752F118A9D85" modified="2005-04-12" version="1" fragment="single">FNILRLFGYLVTMSKVPIYIVTGFLGSGKTTLLRHIISSHDQDAKIAIIQNDFSDEMGIEAPTMQDKDGNLFKEFFELPNGCVCCTVKDELLKAVEHLLSMKRFEKILLETTGIADPEPIIEKFWLDCELETSVELSGVITVIDTYNFKNYLDLELINKKVKCETNKNLLENDRNHLSQESSPNSSSLKLLSPEIIKQIMLANKIVLNKTDLLIENELEKTSNNLQKVAEVEAIVKVINPTANVVTSIKSQVKMDWLFDLDAFNIHKITHEIDRAFNNSLISSHSNNSLLPNISSHTISFSSNAVFDFKSVERAVAKLAWEEDDSLENEDLEEQNQGDLEYDSVNSKYGKFIRFKGIFKAKNSIESDHLNNSIDIYALQGVGQIFEILPININEQVENSKFFFLGIKIDKNKLETLLKSCIIQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWC3</accession>
    <name>Q5CWC3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">General transcription factor TFIIB</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_880</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89316.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626996.1">
        <property type="nucleotide sequence ID" value="XM_626996.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWC3"/>
    <dbReference type="FunCoup" id="Q5CWC3">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWC3"/>
    <dbReference type="GeneID" id="3374417"/>
    <dbReference type="KEGG" id="cpv:cgd8_880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_880"/>
    <dbReference type="InParanoid" id="Q5CWC3"/>
    <dbReference type="OMA" id="LYMACRM"/>
    <dbReference type="OrthoDB" id="25790at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097550">
        <property type="term" value="C:transcription preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017025">
        <property type="term" value="F:TBP-class protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070897">
        <property type="term" value="P:transcription preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.170">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000812">
        <property type="entry name" value="TFIIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013150">
        <property type="entry name" value="TFIIB_cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013137">
        <property type="entry name" value="Znf_TFIIB"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618:SF13">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11618">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIB-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00382">
        <property type="entry name" value="TFIIB"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08271">
        <property type="entry name" value="Zn_Ribbon_TF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00685">
        <property type="entry name" value="TIFACTORIIB"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51134">
        <property type="entry name" value="ZF_TFIIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="2" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="TFIIB-type" evidence="7">
        <location>
            <begin position="148"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="63"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="63"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00031706"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00469"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89316.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="456" mass="50218" checksum="B332DE05A7E445AC" modified="2005-04-12" version="1">MNSDLSSSGVNTNLNIAGNVNSLVDTQNMSSSQANGISSVGNRMDNLTINNTSAASNTINLQRSQLGNSTDGLTGGPIRSSDKLLSDKQNDLGRSNPYPERKIQQTIGESEPTQQVPAIPATIQAGIVSNKDFDKPGALPHLFRSFRATKFCKRCGAGNSIVVYDSKSGSEICTRCGVVVEDRVINEEQEWRSFSNDGNDGNSKSRIGSVNDVWLDDGTDSQLLVGDKKLMKTMLKHNTQASSDRMIKEVFNQLRQIANSFSLHDNIIERCKEIVKEQSNLNILKSGKKHVLAIVYLACREEGVSRTVKELLSFDRTISERELVRSINKLKKDLPRRGPTLSSSAAELMPRFCHYLQLSHEIVGIAEYVCRTAEQYINKSHRPNSLAAGAIYFVCNLCNIQIEMKSVAVAAKSGETTVRGVYKELLLVGEKLLPSDFTPKLVGGIDTLKRRSKIFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWC7</accession>
    <name>Q5CWC7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Nuclear speckle splicing regulatory protein 1 N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NSRP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626992.1">
        <property type="nucleotide sequence ID" value="XM_626992.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWC7"/>
    <dbReference type="GeneID" id="3374414"/>
    <dbReference type="KEGG" id="cpv:cgd8_830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_830"/>
    <dbReference type="InParanoid" id="Q5CWC7"/>
    <dbReference type="OMA" id="VIKQYPR"/>
    <dbReference type="OrthoDB" id="343917at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018612">
        <property type="entry name" value="NSRP1_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09745">
        <property type="entry name" value="NSRP1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nuclear speckle splicing regulatory protein 1 N-terminal" evidence="4">
        <location>
            <begin position="87"/>
            <end position="171"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="79"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="191"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="79"/>
            <end position="88"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09745"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="266" mass="30736" checksum="E23BD7479A2FE564" modified="2005-04-12" version="1">MSKGKFSFSLGKSKEKGPKSLGNVFLGEKVFESEKDENNSAEDLGSKNSDNFQSISTNYEYKKSIKFYNEHPELLKDFDRSNKVKRIEAEDEEEKKDEPKKASLGKSKYLSRIQEYVELRNIEKQEIQEEKIQKEIKEEGNTQVFITDAYKDVLEERKKLKNLLTNRKLSEGEDPRISGPSSIFEMRLSPSTNELNNEESDKQIASGSPKEELNIYNVNSTNSSTTKDYYVVNDDEVSKTSKDLKLIKIQQARERYLLRKQNKNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWJ8</accession>
    <name>Q5CWJ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative degraded Zn-finger +bbox Zn finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_4790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627806.1">
        <property type="nucleotide sequence ID" value="XM_627806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWJ8"/>
    <dbReference type="STRING" id="353152.Q5CWJ8"/>
    <dbReference type="GeneID" id="3375916"/>
    <dbReference type="KEGG" id="cpv:cgd6_4790"/>
    <dbReference type="InParanoid" id="Q5CWJ8"/>
    <dbReference type="OMA" id="ICETCII"/>
    <dbReference type="OrthoDB" id="341068at2759"/>
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        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
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    <dbReference type="CDD" id="cd19756">
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        <property type="match status" value="1"/>
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    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
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    <proteinExistence type="predicted"/>
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    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="B box-type" evidence="3">
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            <begin position="62"/>
            <end position="107"/>
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            <begin position="1"/>
            <end position="35"/>
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        <location>
            <begin position="932"/>
            <end position="972"/>
        </location>
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        <location>
            <begin position="1023"/>
            <end position="1133"/>
        </location>
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        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="935"/>
            <end position="947"/>
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        <location>
            <begin position="959"/>
            <end position="972"/>
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        <location>
            <begin position="1026"/>
            <end position="1044"/>
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        <location>
            <begin position="1051"/>
            <end position="1060"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1069"/>
            <end position="1087"/>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1109"/>
            <end position="1125"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1176" mass="132657" checksum="47963693A52754D5" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWP3</accession>
    <name>Q5CWP3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large protein having a MATH plus possible UBC hydrolase plus type I pseurousyn plus hexapeptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_4290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90028.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_627761.1">
        <property type="nucleotide sequence ID" value="XM_627761.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWP3"/>
    <dbReference type="GeneID" id="3375773"/>
    <dbReference type="KEGG" id="cpv:cgd6_4290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4290"/>
    <dbReference type="InParanoid" id="Q5CWP3"/>
    <dbReference type="OMA" id="RISSHNI"/>
    <dbReference type="OrthoDB" id="428753at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
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        <location>
            <begin position="104"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="397"/>
            <end position="424"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="492"/>
            <end position="514"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="602"/>
            <end position="672"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <end position="857"/>
        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1488"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1625"/>
            <end position="1660"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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            <begin position="2103"/>
            <end position="2126"/>
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    <feature type="region of interest" description="Disordered" evidence="1">
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        <location>
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        <location>
            <begin position="3780"/>
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        </location>
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        <location>
            <begin position="397"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="492"/>
            <end position="506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
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        <location>
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        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
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    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
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            <end position="2807"/>
        </location>
    </feature>
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        <location>
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        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2828"/>
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        </location>
    </feature>
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        <location>
            <begin position="3269"/>
            <end position="3301"/>
        </location>
    </feature>
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        <location>
            <begin position="3310"/>
            <end position="3319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="3403"/>
            <end position="3422"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="3783"/>
            <end position="3799"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90028.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="3805" mass="420626" checksum="6EAE471CB921C53D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWP7</accession>
    <name>Q5CWP7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Conserved oligomeric Golgi complex subunit 7</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">Component of oligomeric Golgi complex 7</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_4250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the COG7 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627757.1">
        <property type="nucleotide sequence ID" value="XM_627757.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWP7"/>
    <dbReference type="GeneID" id="3375891"/>
    <dbReference type="KEGG" id="cpv:cgd6_4250"/>
    <dbReference type="InParanoid" id="Q5CWP7"/>
    <dbReference type="OMA" id="TICERIC"/>
    <dbReference type="OrthoDB" id="341375at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017119">
        <property type="term" value="C:Golgi transport complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006890">
        <property type="term" value="P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019335">
        <property type="entry name" value="COG7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX COMPONENT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21443:SF0">
        <property type="entry name" value="CONSERVED OLIGOMERIC GOLGI COMPLEX SUBUNIT 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0813">Transport</keyword>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004395"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00031345"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="953" mass="110273" checksum="A827581FD1C608C6" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWR2</accession>
    <name>Q5CWR2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Serine aminopeptidase S33 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90011.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627742.1">
        <property type="nucleotide sequence ID" value="XM_627742.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWR2"/>
    <dbReference type="STRING" id="353152.Q5CWR2"/>
    <dbReference type="GeneID" id="3375756"/>
    <dbReference type="KEGG" id="cpv:cgd6_4080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4080"/>
    <dbReference type="InParanoid" id="Q5CWR2"/>
    <dbReference type="OMA" id="HGQSDGW"/>
    <dbReference type="OrthoDB" id="2498029at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022742">
        <property type="entry name" value="Hydrolase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051044">
        <property type="entry name" value="MAG_DAG_Lipase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11614">
        <property type="entry name" value="PHOSPHOLIPASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12146">
        <property type="entry name" value="Hydrolase_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine aminopeptidase S33" evidence="1">
        <location>
            <begin position="289"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF12146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90011.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="506" mass="58536" checksum="B3533F49290F5626" modified="2007-04-03" version="1">MNQFIDEYSVSPDHYCKEKKFSSTRFQSEKSGLMQCYHYFKVEPNQTRKGTALLIHGYSCHTLSEYMNIVENKDLEYNETDISKNHCTRNKNNDNNTPFNKSQFVTTYNGSYIEYFNKKGYDVISLDLEGHGFSQGSKCNTENLDNNCFNIIQMLKIELLKHSGDKNNELKNFQVSSHSWNNEITTNYDIKYEEKGKSDKENEFFLYSSKIHKVNVKDTINNLRTKICIHCSDTGCCFKDTFGEKIIICGISMGGAIALRLAEYIGQICQEDNLDGFQDKSIVKCLRSRLVCIVLLSPMLSLESIKKKTINKIMLPLLPIASYLFPNLQIGSRINNPVCEYITSFSKCDPLYYSKRVKALMCKSLLNYTDAVRDNLNYYPIDVPLLICHCVHDILTDFEGSESTISYFNQSINQIQQFESTESNIESEFVLWPITCKKMSHILTREIGFQDLIEKILEWVSKKESLHESKCKSLRRSEKNSEPLFKSIKNKPFLRQNLNKNIQVSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWS6</accession>
    <name>Q5CWS6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Pleckstrin homology (PH) domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_3910</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89998.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627728.1">
        <property type="nucleotide sequence ID" value="XM_627728.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWS6"/>
    <dbReference type="GeneID" id="3375743"/>
    <dbReference type="KEGG" id="cpv:cgd6_3910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3910"/>
    <dbReference type="InParanoid" id="Q5CWS6"/>
    <dbReference type="OMA" id="WIIRIEK"/>
    <dbReference type="OrthoDB" id="338512at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="2">
        <location>
            <begin position="394"/>
            <end position="500"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="188"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="211"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89998.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="516" mass="59208" checksum="DA75C783B29BF21B" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWV7</accession>
    <name>Q5CWV7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Archeo-eukaryotice exosomal RNAse PH</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_3540</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the RNase PH family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89972.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627697.1">
        <property type="nucleotide sequence ID" value="XM_627697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWV7"/>
    <dbReference type="FunCoup" id="Q5CWV7">
        <property type="interactions" value="16"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWV7"/>
    <dbReference type="GeneID" id="3375717"/>
    <dbReference type="KEGG" id="cpv:cgd6_3540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3540"/>
    <dbReference type="InParanoid" id="Q5CWV7"/>
    <dbReference type="OMA" id="TVCFFHG"/>
    <dbReference type="OrthoDB" id="27298at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000177">
        <property type="term" value="C:cytoplasmic exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000176">
        <property type="term" value="C:nuclear exosome (RNase complex)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071028">
        <property type="term" value="P:nuclear mRNA surveillance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071051">
        <property type="term" value="P:poly(A)-dependent snoRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016075">
        <property type="term" value="P:rRNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034475">
        <property type="term" value="P:U4 snRNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.70">
        <property type="entry name" value="GHMP Kinase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001247">
        <property type="entry name" value="ExoRNase_PH_dom1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036345">
        <property type="entry name" value="ExoRNase_PH_dom2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027408">
        <property type="entry name" value="PNPase/RNase_PH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050080">
        <property type="entry name" value="RNase_PH"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11953:SF2">
        <property type="entry name" value="EXOSOME COMPLEX COMPONENT MTR3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01138">
        <property type="entry name" value="RNase_PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55666">
        <property type="entry name" value="Ribonuclease PH domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0271">Exosome</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="Exoribonuclease phosphorolytic" evidence="9">
        <location>
            <begin position="55"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006678"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF01138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89972.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="303" mass="33517" checksum="53EA101505406EC0" modified="2007-04-03" version="1">MVVFDSFPPLTPISENKSLVKNCDSSTLKKENPGNFNIISENKVLIRNDDRQFEELRPITIRTGVIENADGSAYFSIGNTKVLCGIYGPNLCKQNPIEDGLSVSVEYTIGSFCRDSALAKSKVNTENIEIKSDEKIKSILLEKVISSVICHEKYKRSSIDCYFYIIDDDGSAFSAAISAACLSLCNAKIEIIGLFSATNIIAVNSNSLFNHDGKKQTEDEYSMILDPTYNEISYLGASNYSTLEIGLCTIRNQVVYLSANGDFFKDPKRIEEGFSLAEASCSAIVDEIKDHLTSEFNTNFNES</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWW9</accession>
    <name>Q5CWW9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spindle pole body component</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_3410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
            <location evidence="5">Cytoskeleton</location>
            <location evidence="5">Microtubule organizing center</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the TUBGCP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89963.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627685.1">
        <property type="nucleotide sequence ID" value="XM_627685.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWW9"/>
    <dbReference type="STRING" id="353152.Q5CWW9"/>
    <dbReference type="GeneID" id="3375708"/>
    <dbReference type="KEGG" id="cpv:cgd6_3410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3410"/>
    <dbReference type="InParanoid" id="Q5CWW9"/>
    <dbReference type="OMA" id="MRMMSVC"/>
    <dbReference type="OrthoDB" id="5860513at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000930">
        <property type="term" value="C:gamma-tubulin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000922">
        <property type="term" value="C:spindle pole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043015">
        <property type="term" value="F:gamma-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051011">
        <property type="term" value="F:microtubule minus-end binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031122">
        <property type="term" value="P:cytoplasmic microtubule organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051321">
        <property type="term" value="P:meiotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007020">
        <property type="term" value="P:microtubule nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051225">
        <property type="term" value="P:spindle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1900">
        <property type="entry name" value="Gamma-tubulin complex, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007259">
        <property type="entry name" value="GCP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040457">
        <property type="entry name" value="GCP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042241">
        <property type="entry name" value="GCP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041470">
        <property type="entry name" value="GCP_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19302">
        <property type="entry name" value="GAMMA TUBULIN COMPLEX PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04130">
        <property type="entry name" value="GCP_C_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17681">
        <property type="entry name" value="GCP_N_terminal"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 5" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3 5" id="KW-0493">Microtubule</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Gamma tubulin complex component protein N-terminal" evidence="7">
        <location>
            <begin position="249"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma tubulin complex component C-terminal" evidence="6">
        <location>
            <begin position="580"/>
            <end position="892"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU363050"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04130"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF17681"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89963.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="928" mass="107038" checksum="63987108A252B2CA" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWX1</accession>
    <name>Q5CWX1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic peptide chain release factor subunit 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_3380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="3">Heterodimer of two subunits, one of which binds GTP.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the eukaryotic release factor 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90152.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627683.1">
        <property type="nucleotide sequence ID" value="XM_627683.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWX1"/>
    <dbReference type="FunCoup" id="Q5CWX1">
        <property type="interactions" value="610"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWX1"/>
    <dbReference type="GeneID" id="3375897"/>
    <dbReference type="KEGG" id="cpv:cgd6_3380"/>
    <dbReference type="InParanoid" id="Q5CWX1"/>
    <dbReference type="OMA" id="GPGTEKM"/>
    <dbReference type="OrthoDB" id="10254527at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003747">
        <property type="term" value="F:translation release factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.60:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.960.10:FF:000001">
        <property type="entry name" value="Eukaryotic peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.30:FF:000006">
        <property type="entry name" value="Peptide chain release factor subunit 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.960.10">
        <property type="entry name" value="eRF1 domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.60">
        <property type="entry name" value="eRF1 domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042226">
        <property type="entry name" value="eFR1_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024049">
        <property type="entry name" value="eRF1_1_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005141">
        <property type="entry name" value="eRF1_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005142">
        <property type="entry name" value="eRF1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005140">
        <property type="entry name" value="eRF1_Pelota-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004403">
        <property type="entry name" value="Peptide_chain-rel_eRF1/aRF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029064">
        <property type="entry name" value="Ribosomal_eL30-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03676">
        <property type="entry name" value="aRF1_eRF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10113">
        <property type="entry name" value="PEPTIDE CHAIN RELEASE FACTOR SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03463">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03464">
        <property type="entry name" value="eRF1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03465">
        <property type="entry name" value="eRF1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01194">
        <property type="entry name" value="eRF1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55315">
        <property type="entry name" value="L30e-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55481">
        <property type="entry name" value="N-terminal domain of eukaryotic peptide chain release factor subunit 1, ERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53137">
        <property type="entry name" value="Translational machinery components"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="eRF1/Pelota-like N-terminal" evidence="7">
        <location>
            <begin position="4"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00011520"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90152.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="432" mass="48719" checksum="24ACC29FB8CCBD5A" modified="2005-04-12" version="1" fragment="single">RQEMSDNDTNVKQWKVRRLIATLEAARGNGTSMISLVIKPKDEISRISKMLADEYGTASNIKSRVNRLSVLSAITSTQQRLKLYNRTPQNGLVVYCGTLITEDGKEKKVNIDFEPFKPINTSLYLCDNKFHVDALKELLETDDKFGFIIVDGNGALYGVVQGSSREVLLRFNVDLPKKHGRGGQSALRFARLRMEKRHNYLRKVAETATTMFITNDQVNVAALILAGSADFKNELAQSDIFDQRLASKILKIVDVSYGGDNGFNQAIELSSDALQNVKFVQEKKLITKFFDEVAQDTGKYVYGINETLQALEMGAIELLIVWENLETKRMVVKNPSTGEEKVFLNSPTEQHDESKFKDPETGAELDVIEILPLTEWLVNTYQNYGAQLEFVTNKSQEGNQFQKGFGGFGGILRYKVDFQDYAVVEDDLDEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWZ1</accession>
    <name>Q5CWZ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Sel1 protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_3170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the sel-1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89946.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627663.1">
        <property type="nucleotide sequence ID" value="XM_627663.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWZ1"/>
    <dbReference type="STRING" id="353152.Q5CWZ1"/>
    <dbReference type="GeneID" id="3375691"/>
    <dbReference type="KEGG" id="cpv:cgd6_3170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3170"/>
    <dbReference type="InParanoid" id="Q5CWZ1"/>
    <dbReference type="OMA" id="GFMHYYG"/>
    <dbReference type="OrthoDB" id="27934at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006597">
        <property type="entry name" value="Sel1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050767">
        <property type="entry name" value="Sel1_AlgK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102">
        <property type="entry name" value="SEL-1-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11102:SF147">
        <property type="entry name" value="SEL1L ADAPTOR SUBUNIT OF ERAD E3 UBIQUITIN LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08238">
        <property type="entry name" value="Sel1"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SMART" id="SM00671">
        <property type="entry name" value="SEL1"/>
        <property type="match status" value="9"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81901">
        <property type="entry name" value="HCP-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="791"/>
            <end position="814"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00038101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89946.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="825" mass="94590" checksum="8C1916E6EAE3AFB5" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXA7</accession>
    <name>Q5CXA7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_1810</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627547.1">
        <property type="nucleotide sequence ID" value="XM_627547.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXA7"/>
    <dbReference type="FunCoup" id="Q5CXA7">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="3376061"/>
    <dbReference type="KEGG" id="cpv:cgd6_1810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1810"/>
    <dbReference type="InParanoid" id="Q5CXA7"/>
    <dbReference type="OMA" id="EIWFREC"/>
    <dbReference type="OrthoDB" id="337880at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="224" mass="25818" checksum="28D4B1710C338B81" modified="2005-04-12" version="1">MVQNSFELCKTYNQFKLKNLTEYSYCTPDLLELTQFIIFNSKSSFDTISEVVDVFSFFDTVKRIYYSWQKNPVASRQVDYDLLALLTVFRASNWLNSNQHKILEEYITDLTDGYTNWDVLFPVQNLRIAVERALKSQVTGIVQGRNGVEVWFREGHIGSNQVSGMVILSPCYIQIKDVIDGSMYTYTGGPFPMSPLDFEDILMNCPKSWVYNTSIYSSNSDSQL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXN6</accession>
    <name>Q5CXN6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_5510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90501.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628694.1">
        <property type="nucleotide sequence ID" value="XM_628692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXN6"/>
    <dbReference type="GeneID" id="3372158"/>
    <dbReference type="KEGG" id="cpv:cgd7_5510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5510"/>
    <dbReference type="InParanoid" id="Q5CXN6"/>
    <dbReference type="OrthoDB" id="343302at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="129"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="155"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="130"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90501.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="239" mass="27867" checksum="4CC95716690AC48B" modified="2005-04-12" version="1">MNNFINEMSIKLIYKATKYIFIYMIFALLLKKLEDNSHKISFDSNLSLIKVLNSFENLQIDLMEDPKDLKLAIDTEDINQPDISEKNNSTYVSDKLDAHLEAENDINEKVRVPKIQLLSEVNLVLIGQESKSETESPKSNQDDAEKYEPSNQFNREDLENHISKLTKKVKKLLKELERVEFIVNLYSKAFLSDSSMSNTIKYIKKYEFLKKCHQENLELLSKKKAELDEYQKMLSKTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXP2</accession>
    <name>Q5CXP2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_5450</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90495.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628688.1">
        <property type="nucleotide sequence ID" value="XM_628686.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXP2"/>
    <dbReference type="GeneID" id="3372152"/>
    <dbReference type="KEGG" id="cpv:cgd7_5450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5450"/>
    <dbReference type="InParanoid" id="Q5CXP2"/>
    <dbReference type="OMA" id="QDSCENE"/>
    <dbReference type="OrthoDB" id="343254at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255065" evidence="3">
        <location>
            <begin position="20"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="108"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="200"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="219"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90495.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="334" mass="37304" checksum="6C9A10D902C4A10E" modified="2005-04-12" version="1">MRIFLVLLLVISLSEGIFGIKQEQSKGGNVVNGPQVYNNLKVNNQMRIKSEVGDARNPSQTKIAKMDDSLITSRTAGVEKQDVANNISEVHGYNSLRTSEIIYNGTQVLTLMFFISVIIFGLFILAIALIPRYAKRFGFKSRRDEVPIEQECDDSNFNDIEGKVLVGREKKDNNTMNAPSLTFTKVKNNSLRRHSLISDGSSDSCKITTRPRSSSSLPSVQAFTEAIEESTTGDESSTRASKHITYKSLKKRPHNNDLVGKIYKTNEQNKFSNINFGRNSTRKEDEDSGLSPTSASAVVAIQMSELIARWNPKKDSRLIQKANPMTKERQFNAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXR0</accession>
    <name>Q5CXR0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Translation initiation factor 2, alpha subunit(eIF2-alpha) S1-like RNA binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_5270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eIF-2-alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90658.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628670.1">
        <property type="nucleotide sequence ID" value="XM_628668.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXR0"/>
    <dbReference type="FunCoup" id="Q5CXR0">
        <property type="interactions" value="538"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXR0"/>
    <dbReference type="GeneID" id="3371755"/>
    <dbReference type="KEGG" id="cpv:cgd7_5270"/>
    <dbReference type="InParanoid" id="Q5CXR0"/>
    <dbReference type="OMA" id="DVNEHQR"/>
    <dbReference type="OrthoDB" id="1685042at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005850">
        <property type="term" value="C:eukaryotic translation initiation factor 2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04452">
        <property type="entry name" value="S1_IF2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000015">
        <property type="entry name" value="Eukaryotic translation initiation factor 2 subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1130">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.190">
        <property type="entry name" value="Translation initiation factor 2, subunit 1, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003029">
        <property type="entry name" value="S1_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044126">
        <property type="entry name" value="S1_IF2_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024055">
        <property type="entry name" value="TIF2_asu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024054">
        <property type="entry name" value="TIF2_asu_middle_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011488">
        <property type="entry name" value="TIF_2_asu"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10602:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07541">
        <property type="entry name" value="EIF_2_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00575">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00316">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF110993">
        <property type="entry name" value="eIF-2-alpha, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF116742">
        <property type="entry name" value="eIF2alpha middle domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50126">
        <property type="entry name" value="S1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254351" evidence="5">
        <location>
            <begin position="18"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="domain" description="S1 motif" evidence="6">
        <location>
            <begin position="42"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="297"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="313"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="337"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50126"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90658.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="355" mass="40428" checksum="F5084C7BC9E8BE61" modified="2005-04-12" version="1" fragment="single">PFILLALLSTRILNTWSDLKMETKQQDVVDCRFYENKFPEPEEFVMARVKRITEVGAFVSLLEYNDIEGMILMSELSKRRIRSVNKLTRVGRLEVVVVLRVDKNKGYIDLSKRRVNPEDVERCEEKYSKMKKVYQTVRHIAQKEGISVEELSEKLIWPLHRKYGHALDALKEAAVNPEAVLGEFDLPASVKEALIQDIKFRLSPQQLKLRARIHVCCCGYDGIDAVRHAIIAGQETVTKDDVEIQVKFIAPPQYLVTAVSYGKAAGVEAIEKAMETIKNVITQYKGGDFKRQGEIEVVGGDDEKNDLNSASESENESDYSDSEDEEEDETMGRVEDMDIPFDENDNVEDDDEEGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXW9</accession>
    <name>Q5CXW9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Rf-A (OB fold protein)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_4620</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628611.1">
        <property type="nucleotide sequence ID" value="XM_628609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXW9"/>
    <dbReference type="STRING" id="353152.Q5CXW9"/>
    <dbReference type="GeneID" id="3371949"/>
    <dbReference type="KEGG" id="cpv:cgd7_4620"/>
    <dbReference type="InParanoid" id="Q5CXW9"/>
    <dbReference type="OMA" id="DQCDAFY"/>
    <dbReference type="OrthoDB" id="1751331at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04474">
        <property type="entry name" value="RPA1_DBD_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04475">
        <property type="entry name" value="RPA1_DBD_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04476">
        <property type="entry name" value="RPA1_DBD_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000041">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000064">
        <property type="entry name" value="Replication protein A subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047192">
        <property type="entry name" value="Euk_RPA1_DBD_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013955">
        <property type="entry name" value="Rep_factor-A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031657">
        <property type="entry name" value="REPA_OB_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003871">
        <property type="entry name" value="RFA1B/D_OB_1st"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47165:SF4">
        <property type="entry name" value="OS03G0429900 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02721">
        <property type="entry name" value="DUF223"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08646">
        <property type="entry name" value="Rep_fac-A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16900">
        <property type="entry name" value="REPA_OB_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0235">DNA replication</keyword>
    <keyword evidence="7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Replication protein A 70 kDa DNA-binding subunit B/D first OB fold" evidence="10">
        <location>
            <begin position="213"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="domain" description="Replication protein A OB" evidence="12">
        <location>
            <begin position="333"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="domain" description="Replication factor A C-terminal" evidence="11">
        <location>
            <begin position="502"/>
            <end position="659"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="86"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="103"/>
            <end position="129"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="130"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="169"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="187"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005690"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF02721"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF16900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK90646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="707" mass="77719" checksum="75B7C506E8311E42" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXZ4</accession>
    <name>Q5CXZ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Signal peptide, secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628586.1">
        <property type="nucleotide sequence ID" value="XM_628584.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXZ4"/>
    <dbReference type="GeneID" id="3372166"/>
    <dbReference type="KEGG" id="cpv:cgd7_4320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4320"/>
    <dbReference type="InParanoid" id="Q5CXZ4"/>
    <dbReference type="OrthoDB" id="342962at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="343" mass="39850" checksum="BE48FE85A2D23557" modified="2005-04-12" version="1">MTNIRKTSCISLFVSKILVLTFFLVIFTSDFEIQNRLAHFQETSLLRFSEGPIKDEESESSGSESSNLKATSILLEIDNQEVENEVNPEAKLKTGNTNVIGSDMSEYSLDTVDELISPIVSMCLIELTNIYDILELEYNSISSVSILDNLEECINTRNKINEILKIIIKAKELLFYEKNSNLLDSNSLNEDSRKETNNKKSKTSDLFFYLQANMSILKKTISFYNIKYRVYSSQEQILGRITKLMNEINTLIHRFKNLTKNNKNTFERVMFEITKPVSKVINEYKSILKKTHLFMSTKYYSKHSKNIEHYVQTISCMLKHRLQRSSTFDELLFMLKPTFKLCQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY16</accession>
    <name>Q5CY16_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">protein disulfide-isomerase</fullName>
            <ecNumber evidence="4">5.3.4.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd7_4080</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>Catalyzes the rearrangement of -S-S- bonds in proteins.</text>
            <dbReference type="EC" id="5.3.4.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 11">Belongs to the protein disulfide isomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.3.4.1" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90640.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628564.1">
        <property type="nucleotide sequence ID" value="XM_628562.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY16"/>
    <dbReference type="FunCoup" id="Q5CY16">
        <property type="interactions" value="309"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY16"/>
    <dbReference type="GeneID" id="3371943"/>
    <dbReference type="KEGG" id="cpv:cgd7_4080"/>
    <dbReference type="InParanoid" id="Q5CY16"/>
    <dbReference type="OMA" id="KQKLWGW"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003756">
        <property type="term" value="F:protein disulfide isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034976">
        <property type="term" value="P:response to endoplasmic reticulum stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02983">
        <property type="entry name" value="P5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03001">
        <property type="entry name" value="PDI_a_P5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005788">
        <property type="entry name" value="PDI_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057305">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01126">
        <property type="entry name" value="pdi_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45815:SF3">
        <property type="entry name" value="PROTEIN DISULFIDE-ISOMERASE A6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24541">
        <property type="entry name" value="Thioredox_PDIA6_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="9 14" id="KW-0413">Isomerase</keyword>
    <keyword evidence="10" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0732">Signal</keyword>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="29"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="13">
        <location>
            <begin position="174"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="155"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="412"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="155"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="427"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023284"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004208"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK90640.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="451" mass="50516" checksum="B63E52AA9CFE0455" modified="2005-04-12" version="1" fragment="single">IFFTEDFLESFSIRLKVNTLQMRNLLKLILTLSFAPLFVTCLYDSSSQVKVINGSQLKKLVKENPVVIVEFFAEWCGHCKAFAPEYEKAAKALKGIVPVVAIDDQSDMAEYGIQGFPTVKVFTEHSVKPKDFTGPRRAESVLNAALSALKDVTNSRLSGKNSGNKGSNKTKESSKKSRKSRVVELTDSNFDDLVINDNENSWFVKFYAPWCGHCKSLAPDWEELGSMADGRVKIAKLDATQHTMMAHRYKIQGFPTLLMFPAGEKREITPVNYNGPRTANDLFEFAIKFQSSSASIKQMISQEVFENTCTKGLCVIAFLPHIADSSDSEREKYLKIYKDVVSASAAMTIRFLWSEGGSQFDFEEKLNLAFGYPAVVAINNEKQRFSTHRGSFTVESLNSFIIALTTGRAPVDPLPKLPKISKVSSWEPKKSKENSNAEENRNKSNRQSDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYA6</accession>
    <name>Q5CYA6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_3070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628474.1">
        <property type="nucleotide sequence ID" value="XM_628472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYA6"/>
    <dbReference type="GeneID" id="3372290"/>
    <dbReference type="KEGG" id="cpv:cgd7_3070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3070"/>
    <dbReference type="InParanoid" id="Q5CYA6"/>
    <dbReference type="OMA" id="RAYAGHY"/>
    <dbReference type="OrthoDB" id="338567at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254644" evidence="3">
        <location>
            <begin position="24"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="203"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="39"/>
            <end position="73"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="259" mass="29707" checksum="29D2DB0C1EF69BC8" modified="2005-04-12" version="1">MLNTNSLFLLCCIAFILLGELYAVNLSCDARLRECEVEVKSLLKKNSECSSDLDSLKAEVSHLSEIISQYERNVNFTQDSHHTISWRVAANQLKNFSIFFKGLITASYSNIPKELDLQIRSIYSKIFVYLDPAIEKYSEAYPLVCQHIKSYMNRYINLLNPYIDYMLVYSEFINEKLDGYVSRIESFEPNIVGTIPKSLHDRVFYILCAFLALYVAMESICIALRLLFRCCGIKCGSSCTNKKNIKSPTSKSTPSNRRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYI9</accession>
    <name>Q5CYI9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical membrane protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_2170</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90245.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628391.1">
        <property type="nucleotide sequence ID" value="XM_628389.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYI9"/>
    <dbReference type="GeneID" id="3371893"/>
    <dbReference type="KEGG" id="cpv:cgd7_2170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2170"/>
    <dbReference type="InParanoid" id="Q5CYI9"/>
    <dbReference type="OMA" id="HLEDKEC"/>
    <dbReference type="OrthoDB" id="343656at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014873">
        <property type="entry name" value="VDCC_a1su_IQ"/>
    </dbReference>
    <dbReference type="SMART" id="SM01062">
        <property type="entry name" value="Ca_chan_IQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Voltage-dependent calcium channel alpha-1 subunit IQ" evidence="2">
        <location>
            <begin position="68"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="118"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="268"/>
            <end position="311"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="118"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="163"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="290"/>
            <end position="311"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90245.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="786" mass="89819" checksum="59E03C31897E1529" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYK8</accession>
    <name>Q5CYK8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Coenzyme Q-binding protein COQ10 START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_1950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes.</text>
    </comment>
    <comment type="subunit">
        <text evidence="2">Interacts with coenzyme Q.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the COQ10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90232.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628372.1">
        <property type="nucleotide sequence ID" value="XM_628370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYK8"/>
    <dbReference type="GeneID" id="3371880"/>
    <dbReference type="KEGG" id="cpv:cgd7_1950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1950"/>
    <dbReference type="InParanoid" id="Q5CYK8"/>
    <dbReference type="OMA" id="CEESHVI"/>
    <dbReference type="OrthoDB" id="292693at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048039">
        <property type="term" value="F:ubiquinone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045333">
        <property type="term" value="P:cellular respiration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044996">
        <property type="entry name" value="COQ10-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005031">
        <property type="entry name" value="COQ10_START"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901:SF10">
        <property type="entry name" value="COENZYME Q-BINDING PROTEIN COQ10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12901">
        <property type="entry name" value="SPERM PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03364">
        <property type="entry name" value="Polyketide_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Coenzyme Q-binding protein COQ10 START" evidence="4">
        <location>
            <begin position="28"/>
            <end position="170"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006885"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00024947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF03364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90232.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="189" mass="22386" checksum="A43F4B2A11BA8BAE" modified="2005-04-12" version="1">MLTKKLNRNFFIQSKFSRGIVYFCERLVPYSVPELYSTVIDVAKYRQIFPWISETEITKIWGSIHNRDIFFSRQKIKFGIFGGYLYSIVEGRKPNSIIAYWPPKEVLKIPITIEKFSSFVRSHRTSWEFIGNYKYGLTKVSCKLEFEFDTILMDKIAQRYIKDMTETTINTLINHIKKSESLNTYSLNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYL0</accession>
    <name>Q5CYL0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">FACT complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd7_1930</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Component of the FACT complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="10">Chromosome</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 10">Belongs to the peptidase M24 family. SPT16 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90230.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628370.1">
        <property type="nucleotide sequence ID" value="XM_628368.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYL0"/>
    <dbReference type="FunCoup" id="Q5CYL0">
        <property type="interactions" value="571"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYL0"/>
    <dbReference type="GeneID" id="3371878"/>
    <dbReference type="KEGG" id="cpv:cgd7_1930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1930"/>
    <dbReference type="InParanoid" id="Q5CYL0"/>
    <dbReference type="OMA" id="YHINTIP"/>
    <dbReference type="OrthoDB" id="10251642at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035101">
        <property type="term" value="C:FACT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004177">
        <property type="term" value="F:aminopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031491">
        <property type="term" value="F:nucleosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006368">
        <property type="term" value="P:transcription elongation by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.29.30:FF:000017">
        <property type="entry name" value="FACT complex subunit SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.230.10">
        <property type="entry name" value="Creatinase/methionine aminopeptidase superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.350.10">
        <property type="entry name" value="Creatinase/prolidase N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.210">
        <property type="entry name" value="FACT complex subunit Spt16p/Cdc68p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029149">
        <property type="entry name" value="Creatin/AminoP/Spt16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036005">
        <property type="entry name" value="Creatinase/aminopeptidase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029148">
        <property type="entry name" value="FACT-SPT16_Nlobe"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056595">
        <property type="entry name" value="Fact-SPT16_PH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048969">
        <property type="entry name" value="FACT_SPT16_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013953">
        <property type="entry name" value="FACT_SPT16_M"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000994">
        <property type="entry name" value="Pept_M24"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013719">
        <property type="entry name" value="RTT106/SPT16-like_middle_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040258">
        <property type="entry name" value="Spt16"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980">
        <property type="entry name" value="CDC68 RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13980:SF15">
        <property type="entry name" value="FACT COMPLEX SUBUNIT SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14826">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00557">
        <property type="entry name" value="Peptidase_M24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24824">
        <property type="entry name" value="PH_SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08512">
        <property type="entry name" value="Rttp106-like_middle"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08644">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21091">
        <property type="entry name" value="SPT16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01285">
        <property type="entry name" value="FACT-Spt16_Nlob"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01287">
        <property type="entry name" value="Rtt106"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01286">
        <property type="entry name" value="SPT16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55920">
        <property type="entry name" value="Creatinase/aminopeptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="16" id="KW-0031">Aminopeptidase</keyword>
    <keyword evidence="2 10" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4 10" id="KW-0227">DNA damage</keyword>
    <keyword evidence="8 10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="3 10" id="KW-0235">DNA replication</keyword>
    <keyword evidence="16" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-0645">Protease</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0804">Transcription</keyword>
    <keyword evidence="5 10" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="FACT complex subunit SPT16 N-terminal lobe" evidence="13">
        <location>
            <begin position="8"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="domain" description="FACT complex subunit SPT16 middle" evidence="14">
        <location>
            <begin position="613"/>
            <end position="767"/>
        </location>
    </feature>
    <feature type="domain" description="Histone chaperone RTT106/FACT complex subunit SPT16-like middle" evidence="15">
        <location>
            <begin position="886"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="453"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1004"/>
            <end position="1108"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="461"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="485"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="502"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1011"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="1067"/>
            <end position="1076"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1077"/>
            <end position="1100"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010779"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU367052"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01285"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM01286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM01287"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK90230.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1108" mass="128073" checksum="71A4B27A41985E5F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="137" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYM7</accession>
    <name>Q5CYM7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="16">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="16">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="21" type="ORF">cgd7_1760</name>
    </gene>
    <organism evidence="21 22">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="21 22" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="22">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12 16">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="15">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endomembrane system</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 16">Membrane</location>
            <topology evidence="1 16">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 16">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="21">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="16"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90606.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628353.1">
        <property type="nucleotide sequence ID" value="XM_628351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYM7"/>
    <dbReference type="FunCoup" id="Q5CYM7">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYM7"/>
    <dbReference type="GeneID" id="3371791"/>
    <dbReference type="KEGG" id="cpv:cgd7_1760"/>
    <dbReference type="InParanoid" id="Q5CYM7"/>
    <dbReference type="OMA" id="MHSFWSW"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059000">
        <property type="entry name" value="ATPase_P-type_domA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00122">
        <property type="entry name" value="E1-E2_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 15 16" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11 16" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 15" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 14 16" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="22" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 16" id="KW-1278">Translocase</keyword>
    <keyword evidence="4 16 21" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="10 16" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="50"/>
            <end position="66"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="72"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="343"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="407"/>
            <end position="426"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1059"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1092"/>
            <end position="1114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1143"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1176"/>
            <end position="1197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1204"/>
            <end position="1230"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="16">
        <location>
            <begin position="1245"/>
            <end position="1265"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="19">
        <location>
            <begin position="15"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase A" evidence="18">
        <location>
            <begin position="171"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="20">
        <location>
            <begin position="1030"/>
            <end position="1270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="17">
        <location>
            <begin position="611"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="17">
        <location>
            <begin position="611"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="13">
        <location>
            <position position="469"/>
        </location>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="469"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="470"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="471"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="643"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="686"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="727"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="761"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="841"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="842"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="843"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="976"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="982"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1002"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1005"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="1006"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="1006"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="21">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="Pfam" id="PF00122"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="20">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="EMBL" id="EAK90606.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="22">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1278" mass="143925" checksum="002FF7AFA3BE7507" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYQ9</accession>
    <name>Q5CYQ9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Secreted protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_1370</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90192.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628321.1">
        <property type="nucleotide sequence ID" value="XM_628319.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYQ9"/>
    <dbReference type="GeneID" id="3372238"/>
    <dbReference type="KEGG" id="cpv:cgd7_1370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1370"/>
    <dbReference type="InParanoid" id="Q5CYQ9"/>
    <dbReference type="OrthoDB" id="342850at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254665" description="Secreted protein" evidence="2">
        <location>
            <begin position="31"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="48"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90192.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="193" mass="21879" checksum="FA690FE82D2DFAA1" modified="2005-04-12" version="1">MPYIYNKGFKWFFIATLVFIFGLLILSCRAEEIEGEDIVKLVENDHKQAEDNNQESQKPSSEKVVELEGADLSNETSEVQNPEQIYEACASLQESFEKECSGEQMDKSIQKLVEVCSDPVPDTQEVLTAASEITRNYSDSNFSETTECWAMVYTTSLYISSNSQAVEQEDDESLEIESLETDDSQIESEFENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYT8</accession>
    <name>Q5CYT8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Apicomplexan conserved protein with 2 or more transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd7_1060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628292.1">
        <property type="nucleotide sequence ID" value="XM_628290.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYT8"/>
    <dbReference type="STRING" id="353152.Q5CYT8"/>
    <dbReference type="GeneID" id="3372000"/>
    <dbReference type="KEGG" id="cpv:cgd7_1060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1060"/>
    <dbReference type="InParanoid" id="Q5CYT8"/>
    <dbReference type="OMA" id="LWKNEIF"/>
    <dbReference type="OrthoDB" id="272512at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016746">
        <property type="term" value="F:acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006629">
        <property type="term" value="P:lipid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063:SF52">
        <property type="entry name" value="LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23063">
        <property type="entry name" value="PHOSPHOLIPID ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="38"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="69"/>
            <end position="92"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK90578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="347" mass="39905" checksum="B99E21C69FD0CCC2" modified="2005-04-12" version="1">MEKFRQFADESTGINPYIPIWGQTKTSILRKIIGFPILITRSIILSICLIMFTIFSMVIELMYLEHLRIIFFSIFLNGLSRVILLCFGCIWISENLDKNTKLSSSNDEKKSKTTRKVIYVNRQGFCDIFVCSSILGDPEYLFMDNSGIYLASNSFYALLFSIGLKKNIRGGISFITSSNKLKSIYNNSLRPLIVFMEEVNTNGTCILEWTKMEKIPDTSEMRDLFSENSESIVIQYKLERSLYGPQFTTGDFINHLINMLSKITHFKIDLRIISSQVMKNRISRKNDDKNSNISLKDLQKKRRIDDLLTNIQNIQGKSCNLPIVTSGAEEAQGFIEYWEKTNKGKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYW5</accession>
    <name>Q5CYW5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Bruno-like protein with 2 RRM domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_760</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628265.1">
        <property type="nucleotide sequence ID" value="XM_628263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYW5"/>
    <dbReference type="STRING" id="353152.Q5CYW5"/>
    <dbReference type="GeneID" id="3372018"/>
    <dbReference type="KEGG" id="cpv:cgd7_760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:Cgd7_760"/>
    <dbReference type="InParanoid" id="Q5CYW5"/>
    <dbReference type="OrthoDB" id="267048at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052462">
        <property type="entry name" value="SLIRP/GR-RBP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48027">
        <property type="entry name" value="HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN 87F-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="268"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="365"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="443"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="554"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="450"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="690" mass="77144" checksum="4FD619736E55D539" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYZ6</accession>
    <name>Q5CYZ6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Serine/threonine-protein kinase RIO2</fullName>
            <ecNumber evidence="3">2.7.11.1</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="14">Serine/threonine-protein kinase rio2</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">cgd7_440</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90669.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628234.1">
        <property type="nucleotide sequence ID" value="XM_628232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYZ6"/>
    <dbReference type="FunCoup" id="Q5CYZ6">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYZ6"/>
    <dbReference type="GeneID" id="3371766"/>
    <dbReference type="KEGG" id="cpv:cgd7_440"/>
    <dbReference type="InParanoid" id="Q5CYZ6"/>
    <dbReference type="OMA" id="VKEYAGW"/>
    <dbReference type="OrthoDB" id="10258631at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030688">
        <property type="term" value="C:preribosome, small subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05144">
        <property type="entry name" value="RIO2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000053">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000052">
        <property type="entry name" value="Serine/threonine-protein kinase RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030484">
        <property type="entry name" value="Rio2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015285">
        <property type="entry name" value="RIO2_wHTH_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018934">
        <property type="entry name" value="RIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000687">
        <property type="entry name" value="RIO_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018935">
        <property type="entry name" value="RIO_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852">
        <property type="entry name" value="SER/THR-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45852:SF1">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE RIO2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01163">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09202">
        <property type="entry name" value="Rio2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00090">
        <property type="entry name" value="RIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01245">
        <property type="entry name" value="RIO1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 17" id="KW-0418">Kinase</keyword>
    <keyword evidence="10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="RIO kinase" evidence="16">
        <location>
            <begin position="67"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="332"/>
            <end position="415"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="451"/>
            <end position="488"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="15">
        <location>
            <begin position="342"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="352"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="396"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="17">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009196"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00068353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00068837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM00090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAK90669.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="488" mass="57359" checksum="B1F401CD40CB71A8" modified="2005-04-12" version="1" fragment="single">NTKMKLDVSNMRFISKDEWRILTAVEMGMRNHEYVSPQLIESISNLRRTGSYQLLQNLLRNKLVSRESKIYEGYKLSYLGYDFLALRALNKRGIISSVGARIGVGKESDIHIAADENGKLICLKLHRLGRVSFRNVKNTRDYLRNRKTSSWLYLSRLAALKEYSCLKALYENGFNEGEIKVPEPIDWNRHAIVMELIDAVPLNSIRHLDDPYGALERLMKMIIRLADCGLIHGDFNEFNLLIDSKENITLIDFPQIVNTDHINAEMYFNRDVNCIIELFRKRFGIQVMEYPKFEDVIVFTSDNVHSSNKIINIGKIDRDMNRLDYLNTIISQNNGKNNLDGSELHDNSEISHEEDDSTQEEEEEEEEEEEEEEEEEEEEDDDDDDDEYNCRNQDQDNSDNEHQEEEEYDEIIDKQEYDEFKARAINERINNLWLPRKNKTTQFDKDRIRKSFVSQYDKHHSSKGNSGSKKSREYRKTKAMIDNIKNDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ10</accession>
    <name>Q5CZ10_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Amine oxidase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90521.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628220.1">
        <property type="nucleotide sequence ID" value="XM_628218.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ10"/>
    <dbReference type="STRING" id="353152.Q5CZ10"/>
    <dbReference type="GeneID" id="3372041"/>
    <dbReference type="KEGG" id="cpv:cgd7_270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_270"/>
    <dbReference type="InParanoid" id="Q5CZ10"/>
    <dbReference type="OMA" id="NDICCIC"/>
    <dbReference type="OrthoDB" id="337104at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.660.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002937">
        <property type="entry name" value="Amino_oxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050281">
        <property type="entry name" value="Flavin_monoamine_oxidase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742">
        <property type="entry name" value="FLAVIN MONOAMINE OXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10742:SF410">
        <property type="entry name" value="LYSINE-SPECIFIC HISTONE DEMETHYLASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01593">
        <property type="entry name" value="Amino_oxidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13450">
        <property type="entry name" value="NAD_binding_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="856"/>
            <end position="972"/>
        </location>
    </feature>
    <feature type="domain" description="Amine oxidase" evidence="1">
        <location>
            <begin position="1063"/>
            <end position="1159"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01593"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90521.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1165" mass="132971" checksum="E6751686533C1D9A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ16</accession>
    <name>Q5CZ16_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">OTU domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90517.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628214.1">
        <property type="nucleotide sequence ID" value="XM_628212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ16"/>
    <dbReference type="GeneID" id="3372037"/>
    <dbReference type="KEGG" id="cpv:cgd7_200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_200"/>
    <dbReference type="InParanoid" id="Q5CZ16"/>
    <dbReference type="OMA" id="SAYIIMD"/>
    <dbReference type="OrthoDB" id="339465at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255111" description="OTU domain-containing protein" evidence="1">
        <location>
            <begin position="23"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90517.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="352" mass="40076" checksum="1F48380E022E9B82" modified="2005-04-12" version="1">MLLRVLFLVVFLTCLYDLRVFSAHPYKSIVIHEVEESVIEEQIRAANRIASVSTDSVSLPSKLSAYNYCKTLSKLVGSKYHWGDVSYTWQKRFRRFGYWVCFRDCGGGGDCLYNSIISSLNLSNTSVSMLRRLVADQFVGINTTSLYSSDGNTKTSNIENIIDASGEILNTLNYNNTAHPNSNSNSNYTDLLSNWNETTYLERMEVLATTEAFGDWKDLWSPSSILNSNFQYGTDISTNIKKALLVHKFLSKPGNTHWGAQWDVNYIEKIYNVKVIILWKNRGIFYPTLGDQVDFTKIVLIYYDDAIGHFQVIGLKKMNSPPKSDLISVFSKEKIPTSLKKLYKDDTNNDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPR2</accession>
    <name>A3FPR2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="14">ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Canalicular multispecific organic anion transporter multidrug resist</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd7_4510</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388408.1">
        <property type="nucleotide sequence ID" value="XM_001388371.1"/>
    </dbReference>
    <dbReference type="SMR" id="A3FPR2"/>
    <dbReference type="STRING" id="353152.A3FPR2"/>
    <dbReference type="GeneID" id="3371810"/>
    <dbReference type="KEGG" id="cpv:cgd7_4510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4510"/>
    <dbReference type="InParanoid" id="A3FPR2"/>
    <dbReference type="OMA" id="PYAWPSQ"/>
    <dbReference type="OrthoDB" id="6500128at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18579">
        <property type="entry name" value="ABC_6TM_ABCC_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18580">
        <property type="entry name" value="ABC_6TM_ABCC_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03250">
        <property type="entry name" value="ABCC_MRP_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03244">
        <property type="entry name" value="ABCC_MRP_domain2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.20.1560.10:FF:000013">
        <property type="entry name" value="ABC transporter C family member 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000997">
        <property type="entry name" value="Multidrug resistance-associated protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000074">
        <property type="entry name" value="Multidrug resistance-associated protein 5 isoform 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044746">
        <property type="entry name" value="ABCC_6TM_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044726">
        <property type="entry name" value="ABCC_6TM_D2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="9 11" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 11" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="138"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="215"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="319"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="344"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="423"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="452"/>
            <end position="474"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1020"/>
            <end position="1039"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1075"/>
            <end position="1096"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="1258"/>
            <end position="1283"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="301"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="534"/>
            <end position="755"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="13">
        <location>
            <begin position="1026"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="12">
        <location>
            <begin position="1355"/>
            <end position="1589"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="794"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="886"/>
            <end position="910"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="10">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAZ51601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1592" mass="179156" checksum="117696A5A2ACF677" modified="2007-04-03" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPU6</accession>
    <name>A3FPU6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">PHF5-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the PHF5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388325.1">
        <property type="nucleotide sequence ID" value="XM_001388288.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPU6"/>
    <dbReference type="FunCoup" id="A3FPU6">
        <property type="interactions" value="464"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPU6"/>
    <dbReference type="GeneID" id="3375950"/>
    <dbReference type="KEGG" id="cpv:cgd6_2400"/>
    <dbReference type="InParanoid" id="A3FPU6"/>
    <dbReference type="OMA" id="AYYCWEC"/>
    <dbReference type="OrthoDB" id="10248186at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005345">
        <property type="entry name" value="PHF5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13120">
        <property type="entry name" value="PHD FINGER-LIKE DOMAIN-CONTAINING PROTEIN 5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03660">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF016468">
        <property type="entry name" value="PHF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008626"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="100" mass="11072" checksum="0018E8EF9823E840" modified="2007-04-03" version="1" fragment="single">EPGLLMCRKQPGVAIGRLCVRCEGRCPICDSLVHPETVVRICNECNYGSQKGRCIICGSEGVSDAYYCRECTICEKDRDGCPKIINLGSSKIDSLYQHKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPV6</accession>
    <name>A3FPV6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein uL4</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L4</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_3190</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388335.1">
        <property type="nucleotide sequence ID" value="XM_001388298.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPV6"/>
    <dbReference type="FunCoup" id="A3FPV6">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPV6"/>
    <dbReference type="GeneID" id="3375960"/>
    <dbReference type="KEGG" id="cpv:cgd6_3190"/>
    <dbReference type="InParanoid" id="A3FPV6"/>
    <dbReference type="OMA" id="ALYGTWR"/>
    <dbReference type="OrthoDB" id="10259785at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1370.10:FF:000011">
        <property type="entry name" value="50S ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1370.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025755">
        <property type="entry name" value="Ribos_uL4_C_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002136">
        <property type="entry name" value="Ribosomal_uL4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023574">
        <property type="entry name" value="Ribosomal_uL4_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013000">
        <property type="entry name" value="Ribosomal_uL4_euk/arc_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045240">
        <property type="entry name" value="Ribosomal_uL4_euk/arch"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19431">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14374">
        <property type="entry name" value="Ribos_L4_asso_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00573">
        <property type="entry name" value="Ribosomal_L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52166">
        <property type="entry name" value="Ribosomal protein L4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00939">
        <property type="entry name" value="RIBOSOMAL_L1E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 7" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL4 C-terminal" evidence="6">
        <location>
            <begin position="279"/>
            <end position="351"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00035244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00035353"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF14374"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="394" mass="43251" checksum="469A0B99CF9C9520" modified="2007-04-03" version="1">MTFARPIVSVFPSNDSTKATSSIPLPTVFVSPLRHDLVRYVFTNMSKNKRQAYGVSTKAGHQHSAESWGTGRAVARIPRVSASGTSRSGQGAFGNMCRGGHMFSPNKTYRRFHRKINTTEKRHAVAAAIAATGCPSLVMARGHRINNVPELPLVISNEIQNINKTSTAVEFFKNFGKGLEEEMKRIESSIAIRCGKGKMRNRRRVCAVGPLVVYAEDNGIVKAMRNIKGVDTCSVERLNLLRLAPGGTFGRLTIFTKGAIKRLQEIYGSYTHGSSSKVGYTLPRPAMTNADITRIINSTEVQSVLRPLRGFRCMGSMGRSKTKKNNLTNLTKRACLNPAYTSLRKSARLAQIPGTRLHAIKQRQKAANRALKKSIKQKSETALAAKALSGHNQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ16</accession>
    <name>A3FQ16_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd3_920</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="21" key="2">
        <citation type="submission" date="2008-06" db="PDB data bank">
            <title>Crystal structure of kinase domain of calcium-dependent protein kinase cgd3_920 from Cryptosporidium parvum.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Lew J."/>
                <person name="Lin Y.H."/>
                <person name="Hassanali A."/>
                <person name="Khuu C."/>
                <person name="Alam Z."/>
                <person name="Kozieradzki I."/>
                <person name="Cossar D."/>
                <person name="Bochkarev A."/>
                <person name="Arrowsmith C.H."/>
                <person name="Bountra C."/>
                <person name="Wilkstrom M."/>
                <person name="Edwards A.M."/>
                <person name="Hui R."/>
                <person name="Artz J.D."/>
                <person name="Xiao T."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 70-338</scope>
    </reference>
    <reference evidence="23 24" key="3">
        <citation type="journal article" date="2010" name="ACS Med. Chem. Lett." volume="1" first="331" last="335">
            <title>Discovery of Potent and Selective Inhibitors of Calcium-Dependent Protein Kinase 1 (CDPK1) from C. parvum and T. gondii.</title>
            <authorList>
                <person name="Murphy R.C."/>
                <person name="Ojo K.K."/>
                <person name="Larson E.T."/>
                <person name="Castellanos-Gonzalez A."/>
                <person name="Perera B.G."/>
                <person name="Keyloun K.R."/>
                <person name="Kim J.E."/>
                <person name="Bhandari J.G."/>
                <person name="Muller N.R."/>
                <person name="Verlinde C.L."/>
                <person name="White A.C."/>
                <person name="Merritt E.A."/>
                <person name="Van Voorhis W.C."/>
                <person name="Maly D.J."/>
            </authorList>
            <dbReference type="PubMed" id="21116453"/>
            <dbReference type="DOI" id="10.1021/ml100096t"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) OF 70-538 IN COMPLEX WITH CA(2+)</scope>
    </reference>
    <reference evidence="22" key="4">
        <citation type="journal article" date="2010" name="Nat. Struct. Mol. Biol." volume="17" first="596" last="601">
            <title>Structures of apicomplexan calcium-dependent protein kinases reveal mechanism of activation by calcium.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Artz J.D."/>
                <person name="Finerty P."/>
                <person name="Lin Y.H."/>
                <person name="Amani M."/>
                <person name="Allali-Hassani A."/>
                <person name="Senisterra G."/>
                <person name="Vedadi M."/>
                <person name="Tempel W."/>
                <person name="Mackenzie F."/>
                <person name="Chau I."/>
                <person name="Lourido S."/>
                <person name="Sibley L.D."/>
                <person name="Hui R."/>
            </authorList>
            <dbReference type="PubMed" id="20436473"/>
            <dbReference type="DOI" id="10.1038/nsmb.1795"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 70-538 IN COMPLEX WITH CA(2+)</scope>
    </reference>
    <reference evidence="20" key="5">
        <citation type="journal article" date="2011" name="BMC Genomics" volume="12" first="478" last="478">
            <title>The Cryptosporidium parvum kinome.</title>
            <authorList>
                <person name="Artz J.D."/>
                <person name="Wernimont A.K."/>
                <person name="Allali-Hassani A."/>
                <person name="Zhao Y."/>
                <person name="Amani M."/>
                <person name="Lin Y.H."/>
                <person name="Senisterra G."/>
                <person name="Wasney G.A."/>
                <person name="Fedorov O."/>
                <person name="King O."/>
                <person name="Roos A."/>
                <person name="Lunin V.V."/>
                <person name="Qiu W."/>
                <person name="Finerty P."/>
                <person name="Hutchinson A."/>
                <person name="Chau I."/>
                <person name="von Delft F."/>
                <person name="MacKenzie F."/>
                <person name="Lew J."/>
                <person name="Kozieradzki I."/>
                <person name="Vedadi M."/>
                <person name="Schapira M."/>
                <person name="Zhang C."/>
                <person name="Shokat K."/>
                <person name="Heightman T."/>
                <person name="Hui R."/>
            </authorList>
            <dbReference type="PubMed" id="21962082"/>
            <dbReference type="DOI" id="10.1186/1471-2164-12-478"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 70-338</scope>
    </reference>
    <reference evidence="25" key="6">
        <citation type="submission" date="2015-02" db="PDB data bank">
            <title>Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with AMP.</title>
            <authorList>
                <person name="Merritt E.A."/>
                <person name="Larson E.T."/>
                <person name="Medical Structural Genomics of Pathogenic Protozoa."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 70-538 IN COMPLEX WITH AMP AND CA(2+)</scope>
    </reference>
    <reference evidence="26" key="7">
        <citation type="submission" date="2024-08" db="PDB data bank">
            <title>Crystal Structure of calcium-dependent protein kinase 1 (CDPK1) from Cryptosporidium parvum (AMP/Mg bound).</title>
            <authorList>
                <person name="Liu L."/>
                <person name="Cooper A."/>
                <person name="Lovell S."/>
                <person name="Battaile K.P."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.12 ANGSTROMS) OF 70-538 IN COMPLEX WITH AMP; CA(2+) AND MG(2+)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="11">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388096.1">
        <property type="nucleotide sequence ID" value="XM_001388059.1"/>
    </dbReference>
    <dbReference type="PDB" id="2WEI">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.65 A"/>
        <property type="chains" value="A=70-338"/>
    </dbReference>
    <dbReference type="PDB" id="3DFA">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.45 A"/>
        <property type="chains" value="A=70-338"/>
    </dbReference>
    <dbReference type="PDB" id="3IGO">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.25 A"/>
        <property type="chains" value="A=70-538"/>
    </dbReference>
    <dbReference type="PDB" id="3MWU">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.98 A"/>
        <property type="chains" value="A=70-538"/>
    </dbReference>
    <dbReference type="PDB" id="3NCG">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.49 A"/>
        <property type="chains" value="A=70-538"/>
    </dbReference>
    <dbReference type="PDB" id="4Y5Q">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A=70-538"/>
    </dbReference>
    <dbReference type="PDB" id="9D8S">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.12 A"/>
        <property type="chains" value="A=70-538"/>
    </dbReference>
    <dbReference type="PDBsum" id="2WEI"/>
    <dbReference type="PDBsum" id="3DFA"/>
    <dbReference type="PDBsum" id="3IGO"/>
    <dbReference type="PDBsum" id="3MWU"/>
    <dbReference type="PDBsum" id="3NCG"/>
    <dbReference type="PDBsum" id="4Y5Q"/>
    <dbReference type="AlphaFoldDB" id="A3FQ16"/>
    <dbReference type="SMR" id="A3FQ16"/>
    <dbReference type="STRING" id="353152.A3FQ16"/>
    <dbReference type="BindingDB" id="A3FQ16"/>
    <dbReference type="GeneID" id="3373944"/>
    <dbReference type="KEGG" id="cpv:cgd3_920"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_920"/>
    <dbReference type="InParanoid" id="A3FQ16"/>
    <dbReference type="OMA" id="LEHEWIR"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="EvolutionaryTrace" id="A3FQ16"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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            <begin position="76"/>
            <end position="332"/>
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            <position position="105"/>
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            <name>AMP</name>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
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    </evidence>
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        <source>
            <dbReference type="PROSITE" id="PS50011"/>
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        <source>
            <dbReference type="EMBL" id="EAZ51424.1"/>
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        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
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        <source>
            <dbReference type="PDB" id="2WEI"/>
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        <source>
            <dbReference type="PDB" id="3DFA"/>
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        <source>
            <dbReference type="PDB" id="3IGO"/>
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        <source>
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        <source>
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    </evidence>
    <evidence type="ECO:0007829" key="26">
        <source>
            <dbReference type="PDB" id="9D8S"/>
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    </evidence>
    <sequence length="538" mass="60953" checksum="0F63E3317453496C" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ43</accession>
    <name>A3FQ43_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">phosphatidate phosphatase</fullName>
            <ecNumber evidence="3">3.1.3.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_3210</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the lipin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.4" evidence="3"/>
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        <property type="protein sequence ID" value="EAZ51451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_001388086.1"/>
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    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ43"/>
    <dbReference type="GeneID" id="3373823"/>
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    <dbReference type="InParanoid" id="A3FQ43"/>
    <dbReference type="OMA" id="ATGSMFK"/>
    <dbReference type="OrthoDB" id="4567at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008195">
        <property type="term" value="F:phosphatidate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026058">
        <property type="entry name" value="LIPIN"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031703">
        <property type="entry name" value="Lipin_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007651">
        <property type="entry name" value="Lipin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013209">
        <property type="entry name" value="LNS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031315">
        <property type="entry name" value="LNS2/PITP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181">
        <property type="entry name" value="LIPIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12181:SF12">
        <property type="entry name" value="PHOSPHATIDATE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16876">
        <property type="entry name" value="Lipin_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04571">
        <property type="entry name" value="Lipin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08235">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00775">
        <property type="entry name" value="LNS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="LNS2/PITP" evidence="6">
        <location>
            <begin position="408"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="83"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="110"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005476"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012638"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="575" mass="64038" checksum="A2A5E42C6AA2D1CC" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ69</accession>
    <name>A3FQ69_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Heat shock 40 kDa protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_1800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="submission" date="2007-05" db="PDB data bank">
            <title>Crystal structure of dimerization domain of HSP40 from Cryptosporidium parvum, cgd2_1800.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Lew J."/>
                <person name="Lin L."/>
                <person name="Hassanali A."/>
                <person name="Kozieradzki I."/>
                <person name="Wasney G."/>
                <person name="Vedadi M."/>
                <person name="Walker J.R."/>
                <person name="Zhao Y."/>
                <person name="Schapira M."/>
                <person name="Bochkarev A."/>
                <person name="Weigelt J."/>
                <person name="Sundstrom M."/>
                <person name="Arrowsmith C.H."/>
                <person name="Edwards A.M."/>
                <person name="Hui R."/>
                <person name="Brokx S."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.90 ANGSTROMS) OF 148-326</scope>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388205.1">
        <property type="nucleotide sequence ID" value="XM_001388168.1"/>
    </dbReference>
    <dbReference type="PDB" id="2Q2G">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B=148-326"/>
    </dbReference>
    <dbReference type="PDBsum" id="2Q2G"/>
    <dbReference type="AlphaFoldDB" id="A3FQ69"/>
    <dbReference type="SMR" id="A3FQ69"/>
    <dbReference type="FunCoup" id="A3FQ69">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ69"/>
    <dbReference type="GeneID" id="3373450"/>
    <dbReference type="KEGG" id="cpv:cgd2_1800"/>
    <dbReference type="InParanoid" id="A3FQ69"/>
    <dbReference type="OMA" id="RVCPTCV"/>
    <dbReference type="OrthoDB" id="550424at2759"/>
    <dbReference type="EvolutionaryTrace" id="A3FQ69"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd10747">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000006">
        <property type="entry name" value="DnaJ subfamily B member 13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.260.20:FF:000015">
        <property type="entry name" value="Heat shock protein 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.260.20">
        <property type="entry name" value="Urease metallochaperone UreE, N-terminal domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002939">
        <property type="entry name" value="DnaJ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018253">
        <property type="entry name" value="DnaJ_domain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051339">
        <property type="entry name" value="DnaJ_subfamily_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008971">
        <property type="entry name" value="HSP40/DnaJ_pept-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078:SF553">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY B MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24078">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01556">
        <property type="entry name" value="DnaJ_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49493">
        <property type="entry name" value="HSP40/DnaJ peptide-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00636">
        <property type="entry name" value="DNAJ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0346">Stress response</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="1"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2Q2G"/>
        </source>
    </evidence>
    <sequence length="326" mass="36619" checksum="8CEAA52FF51B1BEF" modified="2007-04-03" version="1" fragment="single">DYYKILGISKDASDQDIKRAYRKLAIKYHPDKQANSTPEGKKKAEEMFKELGEAYEVLSDKEKRNIYNQYGSEGLQAGFGGPTSDQGGMGGGIFIDPNEIFARFFASDRAGSFGDEEGSSFFFSGPSGMFRQVHMSSTHNGRSSTRHAPRSHEVPLLVTLEELYLGKRKKIKVTRKRFIEHKVRNEENIVEVEIKPGWKDGTKLTYSGEGDQESPGTSPGDLVLIIQTKTHPRFTRDDCHLIMKVTIPLVRALTGFTCPVTTLDNRNLQIPIKEIVNPKTRKIVPNEGMPIKNQPGQKGDLILEFDICFPKSLTPEQKKLIKEALD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQL8</accession>
    <name>A3FQL8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">DNA-directed RNA polymerase RBP11-like dimerisation domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_3200</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388073.1">
        <property type="nucleotide sequence ID" value="XM_001388036.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQL8"/>
    <dbReference type="GeneID" id="3372817"/>
    <dbReference type="KEGG" id="cpv:cgd4_3200"/>
    <dbReference type="InParanoid" id="A3FQL8"/>
    <dbReference type="OrthoDB" id="510325at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006383">
        <property type="term" value="P:transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006362">
        <property type="term" value="P:transcription elongation by RNA polymerase I"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF28">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I AND III SUBUNIT RPAC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="5">
        <location>
            <begin position="2"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="44"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="98" mass="10733" checksum="FBCEE7A5A3B196C9" modified="2007-04-03" version="1">MLNPNTTFAGYAIPHPSISTMNLRIETISNVEVDNKNYNLDLKAAPSPSLDKKSSSKKQSSKVGATQILLKACDDLNLICNKIEDKFDKAVQVHLSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQM4</accession>
    <name>A3FQM4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_3760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51267.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388079.1">
        <property type="nucleotide sequence ID" value="XM_001388042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQM4"/>
    <dbReference type="GeneID" id="3372771"/>
    <dbReference type="KEGG" id="cpv:cgd4_3760"/>
    <dbReference type="InParanoid" id="A3FQM4"/>
    <dbReference type="OMA" id="GQCIAET"/>
    <dbReference type="OrthoDB" id="263893at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009542">
        <property type="entry name" value="Spc1/SPCS1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06645">
        <property type="entry name" value="SPC12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51267.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="111" mass="12675" checksum="F9D961CE911ACC40" modified="2007-04-03" version="1" fragment="single">DFSGQDLAYKIQERLVILTGIMSFIIGFYHQKFYYTVLTTLLGLAITLLRFVFLPGQCIAETKLTGSLLKIERKKRKSVKLISKSERSGRKLKQKILLLLCSIQIHTSLKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQN0</accession>
    <name>A3FQN0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd4_240</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="13" key="2">
        <citation type="submission" date="2008-08" db="PDB data bank">
            <title>Crystal Structure of cgd4_240 from cryptosporidium Parvum in complex with indirubin E804.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Fedorov O."/>
                <person name="Lam A."/>
                <person name="Ali A."/>
                <person name="Zhao Y."/>
                <person name="Lew J."/>
                <person name="Wasney G."/>
                <person name="Vedadi M."/>
                <person name="Kozieradzki I."/>
                <person name="Schapira M."/>
                <person name="Bochkarev A."/>
                <person name="Wilstrom M."/>
                <person name="Bountra C."/>
                <person name="Arrowsmith C.H."/>
                <person name="Edwards A.M."/>
                <person name="Hui R."/>
                <person name="Lin Y.H."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 52-433</scope>
        <scope>PHOSPHORYLATION AT TYR-251</scope>
        <scope>DISULFIDE BONDS</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAZ51236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388048.1">
        <property type="nucleotide sequence ID" value="XM_001388011.1"/>
    </dbReference>
    <dbReference type="PDB" id="3EB0">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.65 A"/>
        <property type="chains" value="A/C=52-433"/>
    </dbReference>
    <dbReference type="PDBsum" id="3EB0"/>
    <dbReference type="AlphaFoldDB" id="A3FQN0"/>
    <dbReference type="SMR" id="A3FQN0"/>
    <dbReference type="FunCoup" id="A3FQN0">
        <property type="interactions" value="101"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQN0"/>
    <dbReference type="GeneID" id="3372632"/>
    <dbReference type="KEGG" id="cpv:cgd4_240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_240"/>
    <dbReference type="InParanoid" id="A3FQN0"/>
    <dbReference type="OMA" id="CLHAFFD"/>
    <dbReference type="OrthoDB" id="272141at2759"/>
    <dbReference type="EvolutionaryTrace" id="A3FQN0"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030154">
        <property type="term" value="P:cell differentiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007165">
        <property type="term" value="P:signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14137">
        <property type="entry name" value="STKc_GSK3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000082">
        <property type="entry name" value="Shaggy-related protein kinase kappa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050591">
        <property type="entry name" value="GSK-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039192">
        <property type="entry name" value="STKc_GSK3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057">
        <property type="entry name" value="GLYCOGEN SYNTHASE KINASE-3 ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24057:SF0">
        <property type="entry name" value="PROTEIN KINASE SHAGGY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="13" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6 7 8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 7 8" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="59"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="124"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="88"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="modified residue" description="Phosphotyrosine (covalent)" evidence="13">
        <location>
            <position position="251"/>
        </location>
    </feature>
    <feature type="disulfide bond" evidence="13">
        <location>
            <position position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU000304"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="13">
        <source>
            <dbReference type="PDB" id="3EB0"/>
        </source>
    </evidence>
    <sequence length="433" mass="49227" checksum="F56B7D6F0219BD9D" modified="2007-04-03" version="1">MSNVNVQLSRKQQLLERGCNEMIEEKTNLTNLNHNVTLSSGLSTTATSSTNLETSSKKYSLGKTLGTGSFGIVCEVFDIESGKRFALKKVLQDPRYKNRELDIMKVLDHVNIIKLVDYFYTTGDEEPKPPQPPDDHNKLGGKNNGVNNHHKSVIVNPSQNKYLNVIMEYVPDTLHKVLKSFIRSGRSIPMNLISIYIYQLFRAVGFIHSLGICHRDIKPQNLLVNSKDNTLKLCDFGSAKKLIPSEPSVAYICSRFYRAPELMLGATEYTPSIDLWSIGCVFGELILGKPLFSGETSIDQLVRIIQIMGTPTKEQMIRMNPHYTEVRFPTLKAKDWRKILPEGTPSLAIDLLEQILRYEPDLRINPYEAMAHPFFDHLRNSYESEVKNNSNFPHGVNQNIPQLFNFSPYELSIIPGNVLNRILPKNFSPNYKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQN2</accession>
    <name>A3FQN2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Coiled coil protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAZ51238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388050.1">
        <property type="nucleotide sequence ID" value="XM_001388013.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQN2"/>
    <dbReference type="GeneID" id="3372630"/>
    <dbReference type="KEGG" id="cpv:cgd4_480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_480"/>
    <dbReference type="InParanoid" id="A3FQN2"/>
    <dbReference type="OMA" id="HYEEEMH"/>
    <dbReference type="OrthoDB" id="343216at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159">
        <property type="entry name" value="CENTROSOMAL PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23159:SF31">
        <property type="entry name" value="CENTROSOME-ASSOCIATED PROTEIN CEP250 ISOFORM X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="13"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="555"/>
            <end position="579"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1023"/>
            <end position="1045"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="77"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="302"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="699"/>
            <end position="742"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="886"/>
            <end position="913"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="987"/>
            <end position="1021"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1343" mass="155697" checksum="AC64A93CC86580F8" modified="2007-04-03" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPF2</accession>
    <name>Q5CPF2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_5460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000016">
        <property type="protein sequence ID" value="EAK87299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625310.1">
        <property type="nucleotide sequence ID" value="XM_625310.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPF2"/>
    <dbReference type="STRING" id="353152.Q5CPF2"/>
    <dbReference type="GeneID" id="3375628"/>
    <dbReference type="KEGG" id="cpv:cgd6_5460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5460"/>
    <dbReference type="InParanoid" id="Q5CPF2"/>
    <dbReference type="OrthoDB" id="341861at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254343" evidence="1">
        <location>
            <begin position="24"/>
            <end position="429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="429" mass="48760" checksum="B17A7E333C69F28C" modified="2005-04-12" version="1">MKLISLFIFAILLCQLNIYSVLSKDLDELVGAVGSLNVNTGSKASASLNLQGWPSAQCIRDAKIFGDDGEIIESKLSGVSKKMFVELIILFMQMKVLSRVLQLKELFLSDFWLETNGILTEKVLISNIFSYLKSRSTDELKDPRAVCLFENFGSFLDLCFPGFESVSRETDKQMKAIIQNRDKITCNNPGKALVLFLLIFDENGNKSQQFLMLFLFICTFREFSGLSFSEGLEKVLRNEDNSREKLISISGDTLKNPISLLLKYNSEYSSERKASCGDVAPIQHPLNLSTINVPTFGLKLCFALLELVFVSTSKYVHAFLLLYLASRFNTPEEIMLAFELITFLLRSATDFEEASALLLYDNQLFRSYSDKVLRSHNIDISNLKELFGICLEAKSRHSRFSDIILQTDYQLKSMKKKGKRRKKIKLSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPG4</accession>
    <name>Q5CPG4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_150</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625329.1">
        <property type="nucleotide sequence ID" value="XM_625329.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPG4"/>
    <dbReference type="GeneID" id="3372314"/>
    <dbReference type="KEGG" id="cpv:cgd3_150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_150"/>
    <dbReference type="InParanoid" id="Q5CPG4"/>
    <dbReference type="OMA" id="WAVIRQA"/>
    <dbReference type="OrthoDB" id="336176at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="492" mass="56626" checksum="E11A4AB1264AE665" modified="2005-04-12" version="1">MVLFQWQSEYEYLLHRICDLLDQCKQMGFLHISTDYRNVFTSNSTFQNYILIGSSSMREFMKEMIEKMTPFYTPGILSYLAACCVDDINLSHLFSLLRLHNIMEYYPKSINEHKQRATILTAIFGELYAIKNDFEEGKLKLNDFKRGHVNNSENEQSIELLKMTINQLGGLILDSGRDRATFIKEAFCAPSFAPPKSDIFSINNDELLNNHLQTQVMVNRVSNVNKGDPLLVSALLCGSSLSIWQRIHLLYDPDRNQAKDSIVYAVIYAAPLMDRMRQLVFTSLLQSFCRPQWCNSLLPQLSDKMRRFNNQNTEIIQLIVRGFLLSGVTIWSYESPQQIYDISTSCALTAREKDALLKIFRLVDEKALAQESLEESSIAPSFESVIRELSRQFYTSSNWDIDDTGFVKSLNERQSYNKLGNSIEGALKLAETDYEFMHRPLNIVSDRVKFYQAMQHFQANLNDPLASFESKSDALIQLSSFEDIEANLFNVN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPR3</accession>
    <name>Q5CPR3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ring finger domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_4360</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625451.1">
        <property type="nucleotide sequence ID" value="XM_625451.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPR3"/>
    <dbReference type="STRING" id="353152.Q5CPR3"/>
    <dbReference type="GeneID" id="3372386"/>
    <dbReference type="KEGG" id="cpv:cgd4_4360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4360"/>
    <dbReference type="InParanoid" id="Q5CPR3"/>
    <dbReference type="OMA" id="HTHCILQ"/>
    <dbReference type="OrthoDB" id="8062037at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16448">
        <property type="entry name" value="RING-H2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969:SF69">
        <property type="entry name" value="FINGER DOMAIN PROTEIN, PUTATIVE (AFU_ORTHOLOGUE AFUA_3G12190)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45969">
        <property type="entry name" value="RING ZINC FINGER PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="178"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="489"/>
            <end position="517"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="536"/>
            <end position="641"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="295"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="498"/>
            <end position="511"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="536"/>
            <end position="548"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="558"/>
            <end position="568"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="6">
        <location>
            <begin position="569"/>
            <end position="578"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="589"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="614"/>
            <end position="623"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="657" mass="74815" checksum="50112584DBC92E94" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPZ1</accession>
    <name>Q5CPZ1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 12">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd8_250</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 12"/>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625488.1">
        <property type="nucleotide sequence ID" value="XM_625488.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPZ1"/>
    <dbReference type="FunCoup" id="Q5CPZ1">
        <property type="interactions" value="20"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPZ1"/>
    <dbReference type="GeneID" id="3372506"/>
    <dbReference type="KEGG" id="cpv:cgd8_250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_250"/>
    <dbReference type="InParanoid" id="Q5CPZ1"/>
    <dbReference type="OMA" id="DYYVHFL"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.60.60:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 15" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="14">
        <location>
            <begin position="213"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="146"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="449"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1"/>
            <end position="11"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="158"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="469"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="11">
        <location>
            <position position="387"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK87476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="570" mass="65619" checksum="30297254448D12BD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ34</accession>
    <name>Q5CQ34_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_4300</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87578.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625592.1">
        <property type="nucleotide sequence ID" value="XM_625592.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ34"/>
    <dbReference type="GeneID" id="3372577"/>
    <dbReference type="KEGG" id="cpv:cgd5_4300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4300"/>
    <dbReference type="InParanoid" id="Q5CQ34"/>
    <dbReference type="OMA" id="WAYDRIN"/>
    <dbReference type="OrthoDB" id="342200at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="495"/>
            <end position="512"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="630"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="656"/>
            <end position="674"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="60"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="83"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87578.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="694" mass="80831" checksum="5A5ADFE081B6793E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ54</accession>
    <name>Q5CQ54_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">RNA helicase</fullName>
            <ecNumber evidence="2">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd5_4090</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the DEAD box helicase family. DEAH subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87557.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625572.1">
        <property type="nucleotide sequence ID" value="XM_625572.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ54"/>
    <dbReference type="FunCoup" id="Q5CQ54">
        <property type="interactions" value="19"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ54"/>
    <dbReference type="GeneID" id="3372524"/>
    <dbReference type="KEGG" id="cpv:cgd5_4090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4090"/>
    <dbReference type="InParanoid" id="Q5CQ54"/>
    <dbReference type="OMA" id="NIWPPLD"/>
    <dbReference type="OrthoDB" id="10253254at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18791">
        <property type="entry name" value="SF2_C_RHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000637">
        <property type="entry name" value="ATP-dependent RNA helicase DHX37/DHR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2130">
        <property type="entry name" value="DEAH helicase family, winged-helix domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042035">
        <property type="entry name" value="DEAH_win-hel_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056371">
        <property type="entry name" value="DHX37-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002464">
        <property type="entry name" value="DNA/RNA_helicase_DEAH_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007502">
        <property type="entry name" value="Helicase-assoc_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18934:SF99">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DHX37-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23362">
        <property type="entry name" value="DHX37_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00847">
        <property type="entry name" value="HA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00690">
        <property type="entry name" value="DEAH_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="273"/>
            <end position="466"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="637"/>
            <end position="820"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="34"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="138"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="560"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="655"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="37"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="144"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="154"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="560"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="616"/>
            <end position="625"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="668"/>
            <end position="681"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87557.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1274" mass="147180" checksum="93B0168148ACDEC9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ85</accession>
    <name>Q5CQ85_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_3760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87528.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625541.1">
        <property type="nucleotide sequence ID" value="XM_625541.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ85"/>
    <dbReference type="GeneID" id="3372586"/>
    <dbReference type="KEGG" id="cpv:cgd5_3760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3760"/>
    <dbReference type="InParanoid" id="Q5CQ85"/>
    <dbReference type="OMA" id="GKSANIM"/>
    <dbReference type="OrthoDB" id="361247at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027973">
        <property type="entry name" value="FSAF1-like"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15375">
        <property type="entry name" value="FSAF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87528.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="146" mass="17187" checksum="22E7186EF751A142" modified="2005-04-12" version="1">MKMGSNDFKTGKHKQNSLFNETVREIRKLVYPHLDKFQRQQYDNARAKVLGIKQKKSQKMPLPELISRQKATKRHIDKRKQLEEELDVKLHIGDKANRFEAEKDIKNRKKNKIEKRNMSTSLSGKGFSEKSGVVYVGKNIVKRRKH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ92</accession>
    <name>Q5CQ92_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_3680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87523.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625534.1">
        <property type="nucleotide sequence ID" value="XM_625534.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ92"/>
    <dbReference type="GeneID" id="3372542"/>
    <dbReference type="KEGG" id="cpv:cgd5_3680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3680"/>
    <dbReference type="InParanoid" id="Q5CQ92"/>
    <dbReference type="OMA" id="PAMNITG"/>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045159">
        <property type="entry name" value="DCAF7-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19919">
        <property type="entry name" value="WD REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87523.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="387" mass="43834" checksum="620A31A5D7212363" modified="2005-04-12" version="1">MNECDFEQKSLIIEKTFSKTPYIAYNLEPLNHSNPDDKQTYIALSNLNGKSYYVEVLIYNSESNDLEIGYLYDHIFSPVGGVHWMPRNEVNLEESILGTASDSIRLFKEGNLICDLRLKDLELNSMRLENVYNSYHTKITSFSFSEYIEGDIVSSTLDGRCIIWSVDEAEQIKYSKGAILENLLNEYKSRSILSISQMENFTIMDVCFGYSKDNIIIGVNNGLAVSMDLRSPFKQSSSLLADCILGWDTIPEQKISHTKLCCIKNTSYFCRGILSKGIVEIFDIRKTCGPLFKLNTSKTNLDSSENNIVSIESKNSEEILIAYSNGLINTFNINKENSSNPIEYENNLYTYSFSSLDISKQVNSFLGISSVHMQNNTGIKISKYAKC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQC2</accession>
    <name>Q5CQC2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625726.1">
        <property type="nucleotide sequence ID" value="XM_625726.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQC2"/>
    <dbReference type="GeneID" id="3372616"/>
    <dbReference type="KEGG" id="cpv:cgd4_1290"/>
    <dbReference type="InParanoid" id="Q5CQC2"/>
    <dbReference type="OMA" id="KSKTAPH"/>
    <dbReference type="OrthoDB" id="247013at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006274">
        <property type="term" value="P:DNA replication termination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006735">
        <property type="entry name" value="Rtf2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775">
        <property type="entry name" value="PROTEIN C20ORF43 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12775:SF0">
        <property type="entry name" value="REPLICATION TERMINATION FACTOR 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04641">
        <property type="entry name" value="Rtf2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="60"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="79" mass="9378" checksum="E2164B53F5F938B5" modified="2005-04-12" version="1" fragment="single">TNYYHFQEPLNPPVVICNKGFLYNKEAVINKLLSKSKTAPHIKKLSDVFQVKVSNIHLDYFHHLYLFIYFFFTLNISIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQF6</accession>
    <name>Q5CQF6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the histidine acid phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87647.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625692.1">
        <property type="nucleotide sequence ID" value="XM_625692.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQF6"/>
    <dbReference type="STRING" id="353152.Q5CQF6"/>
    <dbReference type="GeneID" id="3372692"/>
    <dbReference type="KEGG" id="cpv:cgd4_910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_910"/>
    <dbReference type="InParanoid" id="Q5CQF6"/>
    <dbReference type="OMA" id="HKCANYW"/>
    <dbReference type="OrthoDB" id="10257284at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050645">
        <property type="entry name" value="Histidine_acid_phosphatase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567:SF110">
        <property type="entry name" value="2-PHOSPHOXYLOSE PHOSPHATASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11567">
        <property type="entry name" value="ACID PHOSPHATASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254406" evidence="3">
        <location>
            <begin position="17"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87647.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="550" mass="64741" checksum="165755812FEA80F6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQP7</accession>
    <name>Q5CQP7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Ribosomal RNA-processing protein 8</fullName>
            <ecNumber evidence="8">2.1.1.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd4_3800</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">Probable methyltransferase required to silence rDNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
            <location evidence="1 8">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the methyltransferase superfamily. RRP8 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.-" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87750.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625955.1">
        <property type="nucleotide sequence ID" value="XM_625955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQP7"/>
    <dbReference type="FunCoup" id="Q5CQP7">
        <property type="interactions" value="70"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQP7"/>
    <dbReference type="GeneID" id="3372797"/>
    <dbReference type="KEGG" id="cpv:cgd4_3800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3800"/>
    <dbReference type="InParanoid" id="Q5CQP7"/>
    <dbReference type="OMA" id="HEGFRAQ"/>
    <dbReference type="OrthoDB" id="10258825at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008168">
        <property type="term" value="F:methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.2150">
        <property type="entry name" value="Ribosomal RNA-processing protein 8, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007823">
        <property type="entry name" value="RRP8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042036">
        <property type="entry name" value="RRP8_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12787:SF0">
        <property type="entry name" value="RIBOSOMAL RNA-PROCESSING PROTEIN 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05148">
        <property type="entry name" value="Methyltransf_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8 9" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="6 8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="5 8 9" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006301"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU365074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87750.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="369" mass="42716" checksum="238138938744BFD6" modified="2005-04-12" version="1">MLSIRSKSRKSIKGKELYSVRSIGIKKQNGIEVTNRSGNSHTNNYGNSKIIGDKVKNTIIKAYNQSTKNSGPLEIEDSGNNIVSTRLQGSLFRKINEFLYTSDSEKAFNEYIKDGNMFENYHKGYEIQKRSWPIDPLDNIINYISKNKHLKVIGDFGCGTAKIGQTFGHIKGYKVYSFDLNCSKEISEKYNITICNMKNIPLNHKVLDLAVFCLSLMGTDWPLFIKEACRTLKDNGILVIAEVSSRIEDSKSFISNLQNQLNLELVQDPTNLTNYFTLFIFRKKQSNSNQPKNLPTYIQNISFNNFSRKNRYCFSSLKYKYGLKLYWIRKVSKTLKFLKLTNQSLPDSHREKIFYIDHKLLKPCMYKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQR8</accession>
    <name>Q5CQR8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Protein kinase domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_3580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625934.1">
        <property type="nucleotide sequence ID" value="XM_625934.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQR8"/>
    <dbReference type="GeneID" id="3372815"/>
    <dbReference type="KEGG" id="cpv:cgd4_3580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3580"/>
    <dbReference type="InParanoid" id="Q5CQR8"/>
    <dbReference type="OrthoDB" id="340041at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254415" description="Protein kinase domain-containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="888"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="888" mass="101235" checksum="ABB078B31BE625FB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQV4</accession>
    <name>Q5CQV4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_3140</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87924.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625898.1">
        <property type="nucleotide sequence ID" value="XM_625898.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQV4"/>
    <dbReference type="FunCoup" id="Q5CQV4">
        <property type="interactions" value="590"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQV4"/>
    <dbReference type="GeneID" id="3372968"/>
    <dbReference type="KEGG" id="cpv:cgd4_3140"/>
    <dbReference type="InParanoid" id="Q5CQV4"/>
    <dbReference type="OMA" id="IWDIRPY"/>
    <dbReference type="OrthoDB" id="1068471at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052234">
        <property type="entry name" value="U5_snRNP_Component"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44006:SF1">
        <property type="entry name" value="U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 40 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 5" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="90"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="133"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="216"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="277"/>
            <end position="308"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="309"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87924.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="343" mass="38271" checksum="C60296662CCF4763" modified="2005-04-12" version="1" fragment="single">KTSGVVKLRRYTGRKALLISCNWKWNGILYMEHKYGDLNSSSRVYELTGINGECLGTCFTSDGRSILVCGNDPQILLFQNYESSKHGISMQGHTKAVLEVSMNKQHGLQFSSCSADKTVRYWDIETLKCISKFKGHTKIVNSCKCSNTLIISGSDDGQVRAWDTRIKQNKACVYKYDNKYPITAVSCEGELFRVFAGGIDNSIYMIDMRISTAFTLSTLNDTITGLDVSPDNSFLVSNSMDNQVVIWDIRPHSDLQDRKMGTLVGAKHNFEANLHRVRWNFDGDLLAAASSDTIIYIWSFKHKKLINKLVGHKGATLDISFHPSLPIIASAGSDGRVIVGEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR21</accession>
    <name>Q5CR21_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625831.1">
        <property type="nucleotide sequence ID" value="XM_625831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR21"/>
    <dbReference type="GeneID" id="3372883"/>
    <dbReference type="KEGG" id="cpv:cgd4_2430"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2430"/>
    <dbReference type="InParanoid" id="Q5CR21"/>
    <dbReference type="OMA" id="WIFETIT"/>
    <dbReference type="OrthoDB" id="342863at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254283" evidence="2">
        <location>
            <begin position="21"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="837" mass="97837" checksum="ED92CD2AD0BF7B29" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR23</accession>
    <name>Q5CR23_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_2410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87858.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625829.1">
        <property type="nucleotide sequence ID" value="XM_625829.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR23"/>
    <dbReference type="GeneID" id="3372884"/>
    <dbReference type="KEGG" id="cpv:cgd4_2410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2410"/>
    <dbReference type="InParanoid" id="Q5CR23"/>
    <dbReference type="OrthoDB" id="338691at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87858.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="643" mass="75489" checksum="325277AE08F09D9D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR28</accession>
    <name>Q5CR28_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">DSK2 like protein with a ubiquitin domain, 2 STI1 motifs and a UBA domain at its C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_2360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625824.1">
        <property type="nucleotide sequence ID" value="XM_625824.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR28"/>
    <dbReference type="SMR" id="Q5CR28"/>
    <dbReference type="FunCoup" id="Q5CR28">
        <property type="interactions" value="217"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR28"/>
    <dbReference type="GeneID" id="3372979"/>
    <dbReference type="KEGG" id="cpv:cgd4_2360"/>
    <dbReference type="InParanoid" id="Q5CR28"/>
    <dbReference type="OMA" id="KCAEHVD"/>
    <dbReference type="OrthoDB" id="267397at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd14399">
        <property type="entry name" value="UBA_PLICs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16106">
        <property type="entry name" value="Ubl_Dsk2p_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015496">
        <property type="entry name" value="Ubiquilin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019954">
        <property type="entry name" value="Ubiquitin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677:SF3">
        <property type="entry name" value="FI07626P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10677">
        <property type="entry name" value="UBIQUILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23195">
        <property type="entry name" value="UBQLN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00299">
        <property type="entry name" value="UBIQUITIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="3">
        <location>
            <begin position="54"/>
            <end position="123"/>
        </location>
    </feature>
    <feature type="domain" description="UBA" evidence="2">
        <location>
            <begin position="357"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="145"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="402" mass="43797" checksum="0A613C2B8E70CF31" modified="2005-04-12" version="1" fragment="single">NFFSRHIICRIIGALKFEISILKLYISLNSQNYWKLLLRQPAINILKMASIDEISIVFKVSGGTQFNISVPRNTIVKDLKDKISEPSNIPSSQQRLIYKGRILKDSDSLDGMKVESGHTMHLVKSGVQVENQKPTNILDQAADYNSSSGNSQTTNNNNAQNFNSIPSASNDTNNGTNHNSNDPFAAMMNMLNGSDLGFQTQNLRNFSQNSYNGFGGIPNNNNFGNIPDLNSLMNSPIFQQSINELANNPQLVRNILHSNPMFAQLSANNPMLDQMLNNPEMMRMMLNPQMIQSVLNSNNMNSSAANSNPFSSLNGGGPNVAQINGLLNDPSIASMLSGVANGANRSVNSNVPNPAPQMYATQLSQLRDMGFIDTDASLSALQESGGDINAAINKLLERGVGQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR46</accession>
    <name>Q5CR46_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87873.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625806.1">
        <property type="nucleotide sequence ID" value="XM_625806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR46"/>
    <dbReference type="GeneID" id="3372955"/>
    <dbReference type="KEGG" id="cpv:cgd4_2140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2140"/>
    <dbReference type="InParanoid" id="Q5CR46"/>
    <dbReference type="OMA" id="ANDPVAC"/>
    <dbReference type="OrthoDB" id="339973at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="221"/>
            <end position="232"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87873.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="388" mass="43463" checksum="8E3095D72D7AC661" modified="2005-04-12" version="1">MDNNKTEKKEGVKLGELNKVGDSPIGDNIKVIQQSISTIANSNVNTADISTSKLTPAQIRTFQENPKAPLPNNSPVEERWPHLDVVTDIGTTITDLKSGLLDYYGTLFIPSEQDLSSKIDSLRTQDTIHGNYESNRRFINNSEIKVTKDNNGFDVFHKRKNAPLLDDIPDPWSPVPNSIFLYRDANGNPISEKLKMENSEMVDFHGLTEIPGKGSIRAATSKSNKSNKGVGSKSEKSNKVAFDQISIEENGPENLLGFDLKDLAARGALSTRARVPYNDIGEMMECISRNCKDVQNKLLFFEDTLSSYQSNPNMAQFIPPVNESRRFLKNFHSKDPIATYIYTLYRDLYNKSEINSRRIEVIKAKLKVLQSHSKPKMVRIAAHSSLGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR50</accession>
    <name>Q5CR50_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">SET domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87875.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625802.1">
        <property type="nucleotide sequence ID" value="XM_625802.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR50"/>
    <dbReference type="FunCoup" id="Q5CR50">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR50"/>
    <dbReference type="GeneID" id="3372957"/>
    <dbReference type="KEGG" id="cpv:cgd4_2090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2090"/>
    <dbReference type="InParanoid" id="Q5CR50"/>
    <dbReference type="OMA" id="VYDENVY"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd20071">
        <property type="entry name" value="SET_SMYD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR053010">
        <property type="entry name" value="SET_SmydA-8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46455:SF5">
        <property type="entry name" value="SET AND MYND DOMAIN CONTAINING, ARTHROPOD-SPECIFIC, MEMBER 4, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="179"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="43"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="83"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87875.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="583" mass="67506" checksum="A05C1BC58BF96BC4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR88</accession>
    <name>Q5CR88_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myosin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd4_1690</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87907.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625764.1">
        <property type="nucleotide sequence ID" value="XM_625764.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CR88"/>
    <dbReference type="STRING" id="353152.Q5CR88"/>
    <dbReference type="GeneID" id="3372923"/>
    <dbReference type="KEGG" id="cpv:cgd4_1690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1690"/>
    <dbReference type="InParanoid" id="Q5CR88"/>
    <dbReference type="OMA" id="TPKMFCE"/>
    <dbReference type="OrthoDB" id="6108017at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1590">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="107"/>
            <end position="1054"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1249"/>
            <end position="1271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1314"/>
            <end position="1347"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="229"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK87907.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1567" mass="185541" checksum="78399A717C4C3FF5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR91</accession>
    <name>Q5CR91_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative thioredoxin H-type of putative fungal or plant origin, small protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd4_1650</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87951.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625761.1">
        <property type="nucleotide sequence ID" value="XM_625761.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR91"/>
    <dbReference type="STRING" id="353152.Q5CR91"/>
    <dbReference type="GeneID" id="3372767"/>
    <dbReference type="KEGG" id="cpv:cgd4_1650"/>
    <dbReference type="InParanoid" id="Q5CR91"/>
    <dbReference type="OMA" id="CYADWCS"/>
    <dbReference type="OrthoDB" id="2121326at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015035">
        <property type="term" value="F:protein-disulfide reductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02947">
        <property type="entry name" value="TRX_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005746">
        <property type="entry name" value="Thioredoxin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017937">
        <property type="entry name" value="Thioredoxin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46115">
        <property type="entry name" value="THIOREDOXIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000077">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00421">
        <property type="entry name" value="THIOREDOXIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00194">
        <property type="entry name" value="THIOREDOXIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0676">Redox-active center</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="1"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="31"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="2">
        <location>
            <position position="34"/>
        </location>
    </feature>
    <feature type="site" description="Deprotonates C-terminal active site Cys" evidence="2">
        <location>
            <position position="25"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="2">
        <location>
            <position position="32"/>
        </location>
    </feature>
    <feature type="site" description="Contributes to redox potential value" evidence="2">
        <location>
            <position position="33"/>
        </location>
    </feature>
    <feature type="disulfide bond" description="Redox-active" evidence="3">
        <location>
            <begin position="31"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PIRSR" id="PIRSR000077-4"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87951.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="105" mass="11900" checksum="52CDB6150AFCD45B" modified="2005-04-12" version="1" fragment="single">YFFPTIFEFLEYKAYISRQGLVVVDYFATWCGPCNMIAPKLEEFSEQVKDVCFIKVDVDSLPSIADAESVRAMPTFKFFLNGKEVKSVVGANFEIIQQAVLANKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRH5</accession>
    <name>Q5CRH5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">WH2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87989.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626211.1">
        <property type="nucleotide sequence ID" value="XM_626211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRH5"/>
    <dbReference type="GeneID" id="3373227"/>
    <dbReference type="KEGG" id="cpv:cgd5_2750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2750"/>
    <dbReference type="InParanoid" id="Q5CRH5"/>
    <dbReference type="OMA" id="YANDIRQ"/>
    <dbReference type="OrthoDB" id="341014at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003124">
        <property type="entry name" value="WH2_dom"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51082">
        <property type="entry name" value="WH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="WH2" evidence="2">
        <location>
            <begin position="774"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="623"/>
            <end position="688"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="726"/>
            <end position="769"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="659"/>
            <end position="679"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="733"/>
            <end position="757"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="758"/>
            <end position="768"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87989.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="852" mass="97245" checksum="C71D8AF6C99B63EC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRJ2</accession>
    <name>Q5CRJ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_2570</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87977.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626194.1">
        <property type="nucleotide sequence ID" value="XM_626194.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRJ2"/>
    <dbReference type="STRING" id="353152.Q5CRJ2"/>
    <dbReference type="GeneID" id="3373159"/>
    <dbReference type="KEGG" id="cpv:cgd5_2570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2570"/>
    <dbReference type="InParanoid" id="Q5CRJ2"/>
    <dbReference type="OrthoDB" id="343399at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87977.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="368" mass="41591" checksum="235D67D10C904D70" modified="2005-04-12" version="1">MEARAIQIYKPVNKNEVRLVYRIKNSSVSGENGRHQKSYSFNKYGEENAWNMARDAFKFINNNNKLPFDFSDPWKMKLINKRGRKSLSYNGSSINEQNSPSVTSNKRLASLKNELYSENLIERNVTASNNNAANHSPPSISSVKYSSLKGHYNNIDSSSSPVSPEVSPNFVFKFENNFSDLDMKSSHKDYHLPSSSYLYLLATAATEIFEKQEVVSAEKNVVALDNSNDFLQESNDDLKKATTSQSKVENVGFDTSLIHQIIQFNHQSQSKSTNLNQSWSSTASSSSPTLSQVLLPEIPKIMLNPDSYFNLANMPYYNVPLYFNNQPSNQYHPALINNINQNIMLLDPSFSYLSSKNNSNLSTIQIPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRL2</accession>
    <name>Q5CRL2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">60S acidic ribosomal protein LP1 like protein of possible plant origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_2370</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein P1/P2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626174.1">
        <property type="nucleotide sequence ID" value="XM_626174.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRL2"/>
    <dbReference type="FunCoup" id="Q5CRL2">
        <property type="interactions" value="182"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRL2"/>
    <dbReference type="GeneID" id="3373144"/>
    <dbReference type="KEGG" id="cpv:cgd5_2370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2370"/>
    <dbReference type="InParanoid" id="Q5CRL2"/>
    <dbReference type="OMA" id="REELMCV"/>
    <dbReference type="OrthoDB" id="2194681at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030295">
        <property type="term" value="F:protein kinase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006414">
        <property type="term" value="P:translational elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd05831">
        <property type="entry name" value="Ribosomal_P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.1410:FF:000001">
        <property type="entry name" value="60S acidic ribosomal protein P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1410">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01478">
        <property type="entry name" value="Ribosomal_L12_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038716">
        <property type="entry name" value="P1/P2_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027534">
        <property type="entry name" value="Ribosomal_P1/P2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696">
        <property type="entry name" value="60S ACIDIC RIBOSOMAL PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45696:SF10">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00428">
        <property type="entry name" value="Ribosomal_60s"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="86"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="86"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005436"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="122" mass="12153" checksum="897AE58AFA62FD9B" modified="2005-04-12" version="1">MAAVSMNELPQSQVQELICSYAALVLSDGGVPVTSENIKKIISAAGGSVEPYFPGLFAQALSTTNVSDIVAGCGAASVAVPVAGGAGAGAAQDSGASAAADDKKKKEEEEEEEGDLGFSLFD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRP8</accession>
    <name>Q5CRP8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">phosphopyruvate hydratase</fullName>
            <ecNumber evidence="4">4.2.1.11</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd5_1960</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="11">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
        <text evidence="11">Mg(2+) is required for catalysis and for stabilizing the dimer.</text>
    </comment>
    <comment type="pathway">
        <text evidence="2">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the enolase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.1.11" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626138.1">
        <property type="nucleotide sequence ID" value="XM_626138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRP8"/>
    <dbReference type="SMR" id="Q5CRP8"/>
    <dbReference type="STRING" id="353152.Q5CRP8"/>
    <dbReference type="GeneID" id="3373082"/>
    <dbReference type="KEGG" id="cpv:cgd5_1960"/>
    <dbReference type="InParanoid" id="Q5CRP8"/>
    <dbReference type="OMA" id="RCMMSHR"/>
    <dbReference type="OrthoDB" id="1739814at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00187"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000015">
        <property type="term" value="C:phosphopyruvate hydratase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004634">
        <property type="term" value="F:phosphopyruvate hydratase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03313">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.20.20.120:FF:000002">
        <property type="entry name" value="Enolase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.120">
        <property type="entry name" value="Enolase-like C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.390.10">
        <property type="entry name" value="Enolase-like, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00318">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000941">
        <property type="entry name" value="Enolase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036849">
        <property type="entry name" value="Enolase-like_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029017">
        <property type="entry name" value="Enolase-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020810">
        <property type="entry name" value="Enolase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020809">
        <property type="entry name" value="Enolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020811">
        <property type="entry name" value="Enolase_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01060">
        <property type="entry name" value="eno"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11902:SF1">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00113">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03952">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001400">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00148">
        <property type="entry name" value="ENOLASE"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00002">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00178">
        <property type="entry name" value="enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00001">
        <property type="entry name" value="Enolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01192">
        <property type="entry name" value="Enolase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01193">
        <property type="entry name" value="Enolase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51604">
        <property type="entry name" value="Enolase C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54826">
        <property type="entry name" value="Enolase N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00164">
        <property type="entry name" value="ENOLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="8" id="KW-0456">Lyase</keyword>
    <keyword evidence="6 11" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Enolase N-terminal" evidence="13">
        <location>
            <begin position="7"/>
            <end position="142"/>
        </location>
    </feature>
    <feature type="domain" description="Enolase C-terminal TIM barrel" evidence="12">
        <location>
            <begin position="152"/>
            <end position="444"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor" evidence="9">
        <location>
            <position position="220"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="9">
        <location>
            <position position="356"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="168"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="177"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="255"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="11">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="331"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="383"/>
            <end position="386"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012058"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PIRSR" id="PIRSR001400-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM01192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK88234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="449" mass="48722" checksum="FD18902CA29DC952" modified="2005-04-12" version="1" fragment="single">SLAMPSILSVKAREILDSRGNPTVEAEITTEQGVFRACCPSGASTGIYEAKELRDGDEKRYLGKGVQKAVENVNKIIAPALIGKDPTHQTELDTMMTEQLDGSKNEYGFTKSKLGANATTAVSFALARAGAAARGVPLYKYIAELAGNDTNNFVMPVPSFNVLNGGKHAGNALAPQEFMIFPVGAPNFKEALRYGAEVYHTLKSVIKKKYGLGATNIGDEGGFAPDIATPEEALDLITEAINICGYSGKIKISLDPAASEFFVEDKKCYDLNFKCKDSNNYLSSQELTEMWKNICSKYDIASIEDPFDQDDYEAYASLTSQVGEKVQIMGDDLFVTNMSRLRIGKEKGACNALLLKVNQIGTVTEAIAAFDLARSFGWGIQVSHRSGETEDTFIADLTVGLGTGQLKTGAPCRSERVAKYNQLMRIEEELGNNCSFAGANFRKPIARIR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRQ1</accession>
    <name>Q5CRQ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1930</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88072.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626135.1">
        <property type="nucleotide sequence ID" value="XM_626135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRQ1"/>
    <dbReference type="GeneID" id="3373271"/>
    <dbReference type="KEGG" id="cpv:cgd5_1930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1930"/>
    <dbReference type="InParanoid" id="Q5CRQ1"/>
    <dbReference type="OrthoDB" id="2157866at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="128"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="130"/>
            <end position="148"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88072.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="312" mass="35699" checksum="7600AA816AAE2221" modified="2005-04-12" version="1">MSFSRRSSGGLSSSYDGSLGNLTPFLTHSDPLDSKYLSRSMLEITRDVCYNNSLKRNSKGGESLGKEFNYVQKEKQYSGREESNKLNVDLHSSIDTLHQNKNDTAIGNSENMSRRRFSISYVQNLPNKGIENRYNQKDRNSNYGKDENNSEYLHCRKSSSNIKNNSSYQIEKKSSQPLVNKKMNVYQANQLLCSLLERDPCRLNSSGLYSYNSNDQSYKINTFQDGCKHWYSNNNREMIDPFSDTNNSYIPQYTTNARRAMYELIGASETSRPDPDLSDDDLSLRFVRGTLVVCDIHNKLQLNVVPPIFGKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRQ3</accession>
    <name>Q5CRQ3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">EF-hand domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_1910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88073.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626133.1">
        <property type="nucleotide sequence ID" value="XM_626133.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRQ3"/>
    <dbReference type="GeneID" id="3373272"/>
    <dbReference type="KEGG" id="cpv:cgd5_1910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1910"/>
    <dbReference type="InParanoid" id="Q5CRQ3"/>
    <dbReference type="OMA" id="ECNANIW"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="EF-hand" evidence="3">
        <location>
            <begin position="377"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="89"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="137"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88073.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="460" mass="52688" checksum="5F8C5F4FC1A3DD48" modified="2005-04-12" version="1">MLNSNLSKPVQLNRKTISGTKSSAKKGILIDEPTKPDTQLKRRPSVDIINEELLNQETKAINKEKSNLATRPEPISKVLLEEARAKRANKLTTKQVASSPKSKAVKQSPQKKTVKTKSSVETSGKTVETTKKQQAKKEIIIDHSKELEEELERLLNEISELKEQEKNYKSEISELKTDNEAKLYKIKALEKQKEEQFQNKKNLQLSSELLESGHQQNIDKIQKLIKGCRRELEFGNESSAGVYDTEKGVDKKSDYKAAKRKKENDMGIMGLLLCDKIYDKSYLDQLVMIEESNENIWGLSARDLNELNAVLNIYNSNGMNSTDIKSQLNNLSWFLEISSQRNSSLPHIANALDKISSNKLDFKGFLSNLLVPLFSSSHYSYLDQLFDLFDMDSDSFISLDDMKAVVREIEWEEVFSINDLRFLLKQMSTNIFNKNIDSESNHNIIISREEFNEFFRSILD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRS9</accession>
    <name>Q5CRS9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_1610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626107.1">
        <property type="nucleotide sequence ID" value="XM_626107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRS9"/>
    <dbReference type="GeneID" id="3373017"/>
    <dbReference type="KEGG" id="cpv:cgd5_1610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1610"/>
    <dbReference type="InParanoid" id="Q5CRS9"/>
    <dbReference type="OMA" id="IWVEAYI"/>
    <dbReference type="OrthoDB" id="336729at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="321" mass="36640" checksum="D4C53C2BAA8DF1EF" modified="2005-04-12" version="1">MLNSSPEIKCLVKIHACSFLKNTAHSLKDLSKFLNISFVRIIKVVTNNDNILKPSSYSIYIPENPHIKPMVNEQLWVSSRNLLINEYLQGHKIDLINAGIELLRLITWYLSWNRILEYPNASFSIQHNSPFQVCVFAPNLLLGCVMTYPYLIEDIPVTVLLCANAECYLNEHGLNEKCLSLLNIINFSDFTSTTKKMLNYTRDLGFRTIIICPNIELEEEIVIRLALVGISENGEIVVSGQVEQLSSIECSILFQKRCTLSFRNQNFDPANWISNFVNNHMFIDNKTDILNNEISKMNIDGECVTKIENKLSFALVSNVQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRT9</accession>
    <name>Q5CRT9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_1500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88099.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626097.1">
        <property type="nucleotide sequence ID" value="XM_626097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRT9"/>
    <dbReference type="GeneID" id="3373278"/>
    <dbReference type="KEGG" id="cpv:cgd5_1500"/>
    <dbReference type="InParanoid" id="Q5CRT9"/>
    <dbReference type="OrthoDB" id="339925at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254453" evidence="2">
        <location>
            <begin position="20"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="44"/>
            <end position="65"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88099.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="135" mass="15746" checksum="0AFD0A980D35DA39" modified="2005-04-12" version="1">MLNWFWLTAILLMTLWIESIKSISSIIYITYLLLFIIENWLPKIVTTLISVILLIITCLFSYYSIQIVYSLYLVQLAGGRGDEYVAYYKLRRLIQNSRIDNSNKLSNSVMEKNLIRNTDENSSLIRVSQDSHSNV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRU1</accession>
    <name>Q5CRU1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cysteine rich protein having a signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88102.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626095.1">
        <property type="nucleotide sequence ID" value="XM_626095.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRU1"/>
    <dbReference type="GeneID" id="3373281"/>
    <dbReference type="KEGG" id="cpv:cgd5_1480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1480"/>
    <dbReference type="InParanoid" id="Q5CRU1"/>
    <dbReference type="OMA" id="NRECINA"/>
    <dbReference type="OrthoDB" id="337699at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254174" evidence="1">
        <location>
            <begin position="23"/>
            <end position="1234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88102.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1234" mass="140411" checksum="8CFD73F0ABBAF513" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRZ4</accession>
    <name>Q5CRZ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MRP like MinD family ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd5_900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the Mrp/NBP35 ATP-binding proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626042.1">
        <property type="nucleotide sequence ID" value="XM_626042.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRZ4"/>
    <dbReference type="FunCoup" id="Q5CRZ4">
        <property type="interactions" value="8"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRZ4"/>
    <dbReference type="GeneID" id="3373300"/>
    <dbReference type="KEGG" id="cpv:cgd5_900"/>
    <dbReference type="InParanoid" id="Q5CRZ4"/>
    <dbReference type="OMA" id="YNVKIVW"/>
    <dbReference type="OrthoDB" id="1741334at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140663">
        <property type="term" value="F:ATP-dependent FeS chaperone activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02037">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2020.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.300.130">
        <property type="entry name" value="Fe-S cluster assembly (FSCA)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02040">
        <property type="entry name" value="Mrp_NBP35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034904">
        <property type="entry name" value="FSCA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010376">
        <property type="entry name" value="GBBH-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038492">
        <property type="entry name" value="GBBH-like_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002744">
        <property type="entry name" value="MIP18-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000808">
        <property type="entry name" value="Mrp-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019591">
        <property type="entry name" value="Mrp/NBP35_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044304">
        <property type="entry name" value="NUBPL-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033756">
        <property type="entry name" value="YlxH/NBP35"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42961:SF2">
        <property type="entry name" value="IRON-SULFUR PROTEIN NUBPL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01883">
        <property type="entry name" value="FeS_assembly_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06155">
        <property type="entry name" value="GBBH-like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10609">
        <property type="entry name" value="ParA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117916">
        <property type="entry name" value="Fe-S cluster assembly (FSCA) domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01215">
        <property type="entry name" value="MRP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="5" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIP18 family-like" evidence="7">
        <location>
            <begin position="92"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Gamma-butyrobetaine hydroxylase-like N-terminal" evidence="8">
        <location>
            <begin position="526"/>
            <end position="585"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF06155"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="611" mass="69367" checksum="9953DCD8A7178330" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRZ7</accession>
    <name>Q5CRZ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88149.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626039.1">
        <property type="nucleotide sequence ID" value="XM_626039.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRZ7"/>
    <dbReference type="STRING" id="353152.Q5CRZ7"/>
    <dbReference type="GeneID" id="3373136"/>
    <dbReference type="KEGG" id="cpv:cgd5_860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_860"/>
    <dbReference type="InParanoid" id="Q5CRZ7"/>
    <dbReference type="OMA" id="RINQCKL"/>
    <dbReference type="OrthoDB" id="336562at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88149.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="198" mass="22829" checksum="E2382BBC8ED59201" modified="2005-04-12" version="1">MDSGISENNLFLPELINMMGPLLSGTLFPYNNNTEKANANLLFNSIKEKSKIMINCFSSVPSHQVKNFLMNFEDDKPKIYLDNKQFVLSFNRRDDPNSWIFSDNNSNGNSKKHILISDLIKDIQDDNHWLGEILHSESKRIQNRVNKCKTRYGAILNFLIANSSAIPILVQNKNMKENTLNVCKRVYQGNYCYNTENN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS30</accession>
    <name>Q5CS30_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible alpha beta hydrolase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_460</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88171.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626006.1">
        <property type="nucleotide sequence ID" value="XM_626006.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS30"/>
    <dbReference type="STRING" id="353152.Q5CS30"/>
    <dbReference type="GeneID" id="3373178"/>
    <dbReference type="KEGG" id="cpv:cgd5_460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_460"/>
    <dbReference type="InParanoid" id="Q5CS30"/>
    <dbReference type="OMA" id="CATKMSE"/>
    <dbReference type="OrthoDB" id="431885at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004553">
        <property type="term" value="F:hydrolase activity, hydrolyzing O-glycosyl compounds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008474">
        <property type="term" value="F:palmitoyl-(protein) hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008236">
        <property type="term" value="F:serine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052382">
        <property type="entry name" value="ABHD10_acyl-thioesterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001375">
        <property type="entry name" value="Peptidase_S9_cat"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16138">
        <property type="entry name" value="MYCOPHENOLIC ACID ACYL-GLUCURONIDE ESTERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16138:SF7">
        <property type="entry name" value="PALMITOYL-PROTEIN THIOESTERASE ABHD10, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00326">
        <property type="entry name" value="Peptidase_S9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase S9 prolyl oligopeptidase catalytic" evidence="2">
        <location>
            <begin position="271"/>
            <end position="359"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00326"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="361" mass="42343" checksum="1DC01F793503DCFB" modified="2005-04-12" version="1">MSQNFKNLLRINGIFTYVESNFSLTKYLTQDNKDLQNDQVLIYIYNHGFPDYSIDYNNNENTIEFQLIDNYLCHSEAYKLEIIKDLIDENIKLSRFCGKMRDICLSENHINKLKEKSQIDKFLFVSFNTNGIGKLSQRGEFYDKTLTKDMYDIETIVECFSNILFKNSKLIMIGISTGAFLTFSYSTNYTRKDIKCENEYFISNNNLIGIICIACVDNIPESYILDFNNEQLNEFNELGYTKINTKIPIVKINHINKIKDDLKLISRDYLESYNIFPTYNFLLENKEKVVNYPILLIHGTDDQSVPFQMSLNLLNLNNNFSNKNNRYLRLLKINNGNHLLTNSKHIKKAQNEISNFVFEIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSM4</accession>
    <name>Q5CSM4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2080</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88399.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628043.1">
        <property type="nucleotide sequence ID" value="XM_628043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSM4"/>
    <dbReference type="GeneID" id="3371650"/>
    <dbReference type="KEGG" id="cpv:cgd1_2080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2080"/>
    <dbReference type="InParanoid" id="Q5CSM4"/>
    <dbReference type="OrthoDB" id="343382at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="145"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="196"/>
            <end position="217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88399.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="230" mass="26276" checksum="EDD04B43B88F9518" modified="2005-04-12" version="1">MQKKRENLHKLAILILNSLLILATFFTIFFLNIGYYRWGFSNGSNVKYSVCLNRIYSEGVCINTSVIDFENCSEIIEFENFGSSKTLNSITTNSLTKSIKNTITSIQNASLILTCLIATYLAFLSFSTLILLIKEYLHNKRYAHIFSIILMGASVLFIKSGLLYWISMHFSWGKTFRTENNSTTIQKIYHSLGSGFYTLVGILSLTFAELIILIKILPRDREYSKYSLIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSX4</accession>
    <name>Q5CSX4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">RING finger containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88483.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627943.1">
        <property type="nucleotide sequence ID" value="XM_627943.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSX4"/>
    <dbReference type="GeneID" id="3371559"/>
    <dbReference type="KEGG" id="cpv:cgd1_970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_970"/>
    <dbReference type="InParanoid" id="Q5CSX4"/>
    <dbReference type="OMA" id="CECCNTE"/>
    <dbReference type="OrthoDB" id="341564at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="177"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="114"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="524"/>
            <end position="549"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="125"/>
            <end position="138"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88483.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="833" mass="91102" checksum="8743EBBC0F37DDF0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSY1</accession>
    <name>Q5CSY1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627936.1">
        <property type="nucleotide sequence ID" value="XM_627936.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSY1"/>
    <dbReference type="GeneID" id="3371563"/>
    <dbReference type="KEGG" id="cpv:cgd1_900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_900"/>
    <dbReference type="InParanoid" id="Q5CSY1"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="37"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="66"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="105" mass="12336" checksum="64B24C4DCE7AEB76" modified="2005-04-12" version="1">MTRACFDLKYKVFANSVNLCFLMEFYLYSVLSFTFKTPFSIIVFIHAINFIEWFKLGELSVFESLFYLPAFACYPLCMACILFLAFACKPVFRLLLPKLLIITFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSZ5</accession>
    <name>Q5CSZ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Apicomplexan-conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_720</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88492.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627922.1">
        <property type="nucleotide sequence ID" value="XM_627922.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSZ5"/>
    <dbReference type="GeneID" id="3371568"/>
    <dbReference type="KEGG" id="cpv:cgd1_720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_720"/>
    <dbReference type="InParanoid" id="Q5CSZ5"/>
    <dbReference type="OMA" id="HELIAGC"/>
    <dbReference type="OrthoDB" id="166018at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01427">
        <property type="entry name" value="HAD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899">
        <property type="entry name" value="DOMAIN OOKINETE PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR38899:SF1">
        <property type="entry name" value="PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88492.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="211" mass="24103" checksum="B46A69D27F3AD367" modified="2005-04-12" version="1">MFSSHELVNVPNKKKRIEGLLGGETTLIIVDWDDTLLPTTYLSCNKQLDLKNTNFGRIVADFLKKATELGRVVIITNAEPRWVYETSELYLPEILCFLRVIPICSARQFAQAGPNDLKYWKYRAFNCVIQQFSNSFQGIANIISIGDSQWDRDAVFNVFENNKNIKIIPKAVKFLGSPSFEALGEEILILTSKLEEIVMIDGANIYEMEKW</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSZ6</accession>
    <name>Q5CSZ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88491.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627921.1">
        <property type="nucleotide sequence ID" value="XM_627921.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSZ6"/>
    <dbReference type="STRING" id="353152.Q5CSZ6"/>
    <dbReference type="GeneID" id="3371567"/>
    <dbReference type="KEGG" id="cpv:cgd1_710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_710"/>
    <dbReference type="InParanoid" id="Q5CSZ6"/>
    <dbReference type="OMA" id="SNVERIC"/>
    <dbReference type="OrthoDB" id="337444at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42180:SF4">
        <property type="entry name" value="CALPONIN-HOMOLOGY (CH) DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42180">
        <property type="entry name" value="HOMOLOGY DOMAIN-CONTAINING PROTEIN,PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="245"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="806"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88491.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1171" mass="137168" checksum="18B0A77432BB9712" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT09</accession>
    <name>Q5CT09_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_510</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88512.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627908.1">
        <property type="nucleotide sequence ID" value="XM_627908.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT09"/>
    <dbReference type="GeneID" id="3371549"/>
    <dbReference type="KEGG" id="cpv:cgd1_510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_510"/>
    <dbReference type="InParanoid" id="Q5CT09"/>
    <dbReference type="OMA" id="CKNDVAA"/>
    <dbReference type="OrthoDB" id="340164at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88512.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="594" mass="66429" checksum="DFE58ED79E11D320" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT39</accession>
    <name>Q5CT39_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627878.1">
        <property type="nucleotide sequence ID" value="XM_627878.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT39"/>
    <dbReference type="GeneID" id="3371431"/>
    <dbReference type="KEGG" id="cpv:cgd1_160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_160"/>
    <dbReference type="InParanoid" id="Q5CT39"/>
    <dbReference type="OrthoDB" id="342289at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="7"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="902"/>
            <end position="919"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="734"/>
            <end position="780"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="734"/>
            <end position="748"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="766"/>
            <end position="780"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="933" mass="106815" checksum="E13EC05346AB185B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTA6</accession>
    <name>Q5CTA6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein rich in Thr and Ser residues</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88651.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626563.1">
        <property type="nucleotide sequence ID" value="XM_626563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTA6"/>
    <dbReference type="GeneID" id="3373409"/>
    <dbReference type="KEGG" id="cpv:cgd2_3780"/>
    <dbReference type="InParanoid" id="Q5CTA6"/>
    <dbReference type="OrthoDB" id="344162at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="53"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="169"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="203"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88651.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="379" mass="42128" checksum="064ED6A1BD2D5BA2" modified="2005-04-12" version="1">MPFQNNILKLIDHLSINIGKISFEGLKNVIKGKYVINPIISTEKETTLVDQNTVSDGFEGDSSTSSNGTAEPKPELSKYPDVTVLPTEVFIPENTKSFEPAHARGALGVMPLPMQLPPQPPASHSEDNSQISTIIINESNNHGEHIPETETASEQGFGGRDDTYGPNNKYHHHHHHHHPSYNHHHKHHHQHRPHHPPFNGDNSSSSSTSTSSTSTSTSTSTTSTSTSTTTTTTTTTTTTTTTTTNEEVNAVKNIAQKRNLRRLKKVVLEDEEDEDDEYLDEIEQEREDSKEGNQVTEVGLQITMPIITLIASETKYCGNGVEYLNELSLKFRETIGKLFDLSYEEVFIVKMTSTNKSFVNCNDKNAVQKDKSGVKFTFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTJ4</accession>
    <name>Q5CTJ4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Structural maintenance of chromosomes protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_2750</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 10">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the SMC family. SMC1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88730.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626475.1">
        <property type="nucleotide sequence ID" value="XM_626475.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CTJ4">
        <property type="interactions" value="167"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTJ4"/>
    <dbReference type="GeneID" id="3373474"/>
    <dbReference type="KEGG" id="cpv:cgd2_2750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2750"/>
    <dbReference type="InParanoid" id="Q5CTJ4"/>
    <dbReference type="OMA" id="KHMDFQR"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008278">
        <property type="term" value="C:cohesin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007062">
        <property type="term" value="P:sister chromatid cohesion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03275">
        <property type="entry name" value="ABC_SMC1_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028468">
        <property type="entry name" value="Smc1_ABC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF12">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="5" id="KW-0132">Cell division</keyword>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="7 11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="8 10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="12">
        <location>
            <begin position="568"/>
            <end position="695"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="241"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="308"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="446"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="733"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="897"/>
            <end position="973"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="1057"/>
            <end position="1118"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005597"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PIRNR" id="PIRNR005719"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88730.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1349" mass="155922" checksum="AF275EDF8849A5F2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTN6</accession>
    <name>Q5CTN6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclin 6 pcl7</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2290</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626433.1">
        <property type="nucleotide sequence ID" value="XM_626433.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTN6"/>
    <dbReference type="STRING" id="353152.Q5CTN6"/>
    <dbReference type="GeneID" id="3373513"/>
    <dbReference type="KEGG" id="cpv:cgd2_2290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2290"/>
    <dbReference type="InParanoid" id="Q5CTN6"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="307" mass="35438" checksum="A96A7FE67DB0CAA0" modified="2005-04-12" version="1">MKGDSEVSTNPNSKILGESVPEIKNYLHFPGEANLYPNQLMRRRIIVNDENGFKKSKCSVLDDLIIGDLNFLLRIIDAKYNAYTILKRIRLSEIVENYKVFEDKEVNEESNLLDVLHLFPKNYTSENKAINIHDSVLMDRYSFGRAMSDIMLILQCLPTRKANSEFCTLFDSEINPPISIKDYFARLSEYFLCSPSLFVLMFIYIKRIIDNNPSYIFDTKSAHRLMLATLVISVKLYDDKFLPNTHYAHVGGVSETELSRLEVDALLLMDFRLKVTIEEFVKFSYSLRFLGEVIKKYGIAFGDSNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTQ8</accession>
    <name>Q5CTQ8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Protein HGH1 homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_2040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HGH1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626411.1">
        <property type="nucleotide sequence ID" value="XM_626411.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTQ8"/>
    <dbReference type="STRING" id="353152.Q5CTQ8"/>
    <dbReference type="GeneID" id="3373529"/>
    <dbReference type="KEGG" id="cpv:cgd2_2040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2040"/>
    <dbReference type="InParanoid" id="Q5CTQ8"/>
    <dbReference type="OMA" id="YIMLVAN"/>
    <dbReference type="OrthoDB" id="338814at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039717">
        <property type="entry name" value="Hgh1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007206">
        <property type="entry name" value="Protein_HGH1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007205">
        <property type="entry name" value="Protein_HGH1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13387:SF9">
        <property type="entry name" value="PROTEIN HGH1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04063">
        <property type="entry name" value="DUF383"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04064">
        <property type="entry name" value="DUF384"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Protein HGH1 N-terminal" evidence="3">
        <location>
            <begin position="121"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="domain" description="Protein HGH1 C-terminal" evidence="4">
        <location>
            <begin position="343"/>
            <end position="395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006712"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00014076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04063"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF04064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="406" mass="46605" checksum="B362F4140F5E243C" modified="2005-04-12" version="1">MEEDDKINLFGVYEELFHLLRDGKDEVIKGSMELLLDQSEMESLSEFLSNNPNYFRSILLLIGNDISSISECALKILINLSQKSEIGEELCRNWSAIEYSMDNLREQIKSNSTVPYHLSLNLMLISNLTRYSKGREKFFDKSRQSKSFYLTYLLECLSNSRDEKEKEMIISILNNCTYCSQGRVFLFDSNLGIELLNKVSELMLATSRKDDLIMTKSVMSIITHVCLDKNLHTIISKKDCNVIPSLCCLVYPNESHLNLRYRKSSNILSELQNKTIFFDSKREGTNSDNISFNEFDNGNPKKNCGGDYEEFTDSAAEDKVSEFIKKNAIGPVNKNISQDVFDCILVLISTVNGRTFLRELGAYEVLRVWHLYESKDEIISGIEDIIHLLVYSEDELLQQDNSFIDA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTU6</accession>
    <name>Q5CTU6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">TRUD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_1510</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626373.1">
        <property type="nucleotide sequence ID" value="XM_626373.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTU6"/>
    <dbReference type="FunCoup" id="Q5CTU6">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTU6"/>
    <dbReference type="GeneID" id="3373721"/>
    <dbReference type="KEGG" id="cpv:cgd2_1510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1510"/>
    <dbReference type="InParanoid" id="Q5CTU6"/>
    <dbReference type="OMA" id="EQMINAT"/>
    <dbReference type="OrthoDB" id="447290at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001522">
        <property type="term" value="P:pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02576">
        <property type="entry name" value="PseudoU_synth_ScPUS7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.20">
        <property type="entry name" value="TruD, catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001656">
        <property type="entry name" value="PsdUridine_synth_TruD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011760">
        <property type="entry name" value="PsdUridine_synth_TruD_insert"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042214">
        <property type="entry name" value="TruD_catalytic"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00094">
        <property type="entry name" value="tRNA_TruD_broad"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326:SF21">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE PUS7L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13326">
        <property type="entry name" value="TRNA PSEUDOURIDINE SYNTHASE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01142">
        <property type="entry name" value="TruD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037016">
        <property type="entry name" value="Pseudouridin_synth_euk_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50984">
        <property type="entry name" value="TRUD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TRUD" evidence="3">
        <location>
            <begin position="470"/>
            <end position="706"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="805" mass="93045" checksum="24EEEC89D394ECFE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU13</accession>
    <name>Q5CU13_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Predicted protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_710</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DeSI family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626306.1">
        <property type="nucleotide sequence ID" value="XM_626306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU13"/>
    <dbReference type="STRING" id="353152.Q5CU13"/>
    <dbReference type="MEROPS" id="C97.A10"/>
    <dbReference type="GeneID" id="3373378"/>
    <dbReference type="KEGG" id="cpv:cgd2_710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_710"/>
    <dbReference type="InParanoid" id="Q5CU13"/>
    <dbReference type="OrthoDB" id="412286at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0101005">
        <property type="term" value="F:deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1720.30">
        <property type="entry name" value="PPPDE domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008580">
        <property type="entry name" value="PPPDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042266">
        <property type="entry name" value="PPPDE_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378">
        <property type="entry name" value="DESUMOYLATING ISOPEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12378:SF80">
        <property type="entry name" value="IP06716P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05903">
        <property type="entry name" value="Peptidase_C97"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01179">
        <property type="entry name" value="DUF862"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51858">
        <property type="entry name" value="PPPDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPPDE" evidence="5">
        <location>
            <begin position="76"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="239"/>
            <end position="269"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008140"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51858"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="269" mass="30422" checksum="1DFE09BA22B4960C" modified="2005-04-12" version="1">MNGELNKTQYNTNIKTTNTDYFDQMENISGSNVRGRLTYSDLHVKDSFSHAYSNNNITRCSSNYREENFDRDSGSNMVILNVYDLDAISGSINRFTRVFELGAFHAGIEIYGVEYCFGSTSDGSSGITVNLPRRHPIHIYRESVKMGRTNYSRGEIKRIINEMKPLWLGSDYNIFRRNCLTFADELCMVLNVGQIPNYVKLLPELLCQAGDGLDKVTKHISTIFDRIASNCSNLAIVESEQEEKNDQSTTNSSGMSPKKFPFGIKNPLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU54</accession>
    <name>Q5CU54_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Secreted insulinase like peptidase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_4170</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88952.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626960.1">
        <property type="nucleotide sequence ID" value="XM_626960.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU54"/>
    <dbReference type="GeneID" id="3373890"/>
    <dbReference type="KEGG" id="cpv:cgd3_4170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4170"/>
    <dbReference type="InParanoid" id="Q5CU54"/>
    <dbReference type="OMA" id="RIMTHVI"/>
    <dbReference type="OrthoDB" id="952271at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050626">
        <property type="entry name" value="Peptidase_M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690:SF18">
        <property type="entry name" value="INSULIN-DEGRADING ENZYME-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43690">
        <property type="entry name" value="NARDILYSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="16"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253854" evidence="7">
        <location>
            <begin position="17"/>
            <end position="1289"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="8">
        <location>
            <begin position="81"/>
            <end position="199"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="9">
        <location>
            <begin position="242"/>
            <end position="426"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88952.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1289" mass="150615" checksum="E2B1213A6738B2FF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU83</accession>
    <name>Q5CU83_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cbf5p centromere-binding factor 5 like PUA domain containing protein with a type I pseudouridine synthase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_3850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the pseudouridine synthase TruB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89243.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626931.1">
        <property type="nucleotide sequence ID" value="XM_626931.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU83"/>
    <dbReference type="FunCoup" id="Q5CU83">
        <property type="interactions" value="502"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU83"/>
    <dbReference type="GeneID" id="3373928"/>
    <dbReference type="KEGG" id="cpv:cgd3_3850"/>
    <dbReference type="InParanoid" id="Q5CU83"/>
    <dbReference type="OMA" id="KYGRTNE"/>
    <dbReference type="OrthoDB" id="10250002at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031429">
        <property type="term" value="C:box H/ACA snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000495">
        <property type="term" value="P:box H/ACA sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031118">
        <property type="term" value="P:rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031120">
        <property type="term" value="P:snRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02572">
        <property type="entry name" value="PseudoU_synth_hDyskerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd21148">
        <property type="entry name" value="PUA_Cbf5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.2350.10:FF:000001">
        <property type="entry name" value="H/ACA ribonucleoprotein complex subunit CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.130.10">
        <property type="entry name" value="PUA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012960">
        <property type="entry name" value="Dyskerin-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002501">
        <property type="entry name" value="PsdUridine_synth_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002478">
        <property type="entry name" value="PUA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036974">
        <property type="entry name" value="PUA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004802">
        <property type="entry name" value="tRNA_PsdUridine_synth_B_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032819">
        <property type="entry name" value="TruB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00425">
        <property type="entry name" value="CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003280">
        <property type="entry name" value="PRK04270.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127">
        <property type="entry name" value="CENTROMERE/MICROTUBULE BINDING PROTEIN CBF5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23127:SF0">
        <property type="entry name" value="H_ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT DKC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08068">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01472">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16198">
        <property type="entry name" value="TruB_C_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01509">
        <property type="entry name" value="TruB_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01136">
        <property type="entry name" value="DKCLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00359">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dyskerin-like" evidence="5">
        <location>
            <begin position="31"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="domain" description="PUA" evidence="4">
        <location>
            <begin position="280"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="403"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="425"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="498"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00359"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM01136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89243.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="520" mass="57807" checksum="52A52884E2BA7F85" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUI1</accession>
    <name>Q5CUI1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2750</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89050.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626833.1">
        <property type="nucleotide sequence ID" value="XM_626833.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUI1"/>
    <dbReference type="FunCoup" id="Q5CUI1">
        <property type="interactions" value="290"/>
    </dbReference>
    <dbReference type="GeneID" id="3373961"/>
    <dbReference type="KEGG" id="cpv:cgd3_2750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2750"/>
    <dbReference type="InParanoid" id="Q5CUI1"/>
    <dbReference type="OrthoDB" id="340620at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="246"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="256"/>
            <end position="278"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="285"/>
            <end position="295"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="315"/>
            <end position="325"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89050.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="411" mass="46811" checksum="7D0CE7D2B1127A05" modified="2005-04-12" version="1">MRNNFIDEDIFKTDDISSLIGSETLLNSSCVVIQNVDYTPLQASLIHNSIKIRDFILKQNSIDINIQNSKGENVLITAIVNKAPLTFIKELFRRNIDICLPKDSKFSSIIDFADPSWEGYSELKHMLQRRKSYNFNYRKQNSEKQIENKSNDVEKKETEQSDYSINTIQFGSELAEVEKKNGPDNNIFDLKRPNTMNIDDKNLNTIADQLEIVEGNNALEPINQITNKKNTSRSISKSIFIPKSVIKPNAHSSTSESKKDTKLKNDTQESSSLKHETEISLEPLEAEKKGEENKRNIVQMKNSTTNDEDNGIINNKDKLRSDGNKSSEIISEKMCNIKPSGKNTEPEFTIKKTKNQDFNCDQRGGDYCKYIGVDDEYMSLIDQQLNESIETSKKLFSCACCAGIRPWKSET</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="125" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUI3</accession>
    <name>Q5CUI3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">Phospholipid-transporting ATPase</fullName>
            <ecNumber evidence="15">7.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd3_2730</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 15">
            <text>ATP + H2O + phospholipidSide 1 = ADP + phosphate + phospholipidSide 2.</text>
            <dbReference type="EC" id="7.6.2.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="14">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 15">Membrane</location>
            <topology evidence="1 15">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 15">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.6.2.1" evidence="15"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89054.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626831.1">
        <property type="nucleotide sequence ID" value="XM_626831.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUI3"/>
    <dbReference type="STRING" id="353152.Q5CUI3"/>
    <dbReference type="GeneID" id="3373965"/>
    <dbReference type="KEGG" id="cpv:cgd3_2730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2730"/>
    <dbReference type="InParanoid" id="Q5CUI3"/>
    <dbReference type="OMA" id="QALRCGR"/>
    <dbReference type="OrthoDB" id="377733at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140326">
        <property type="term" value="F:ATPase-coupled intramembrane lipid transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045332">
        <property type="term" value="P:phospholipid translocation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000014">
        <property type="entry name" value="Phospholipid-transporting ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1110.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.150.10">
        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023299">
        <property type="entry name" value="ATPase_P-typ_cyto_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018303">
        <property type="entry name" value="ATPase_P-typ_P_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023298">
        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008250">
        <property type="entry name" value="ATPase_P-typ_transduc_dom_A_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006539">
        <property type="entry name" value="P-type_ATPase_IV"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032631">
        <property type="entry name" value="P-type_ATPase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001757">
        <property type="entry name" value="P_typ_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044492">
        <property type="entry name" value="P_typ_ATPase_HD_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01652">
        <property type="entry name" value="ATPase-Plipid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01494">
        <property type="entry name" value="ATPase_P-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092:SF150">
        <property type="entry name" value="PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24092">
        <property type="entry name" value="PROBABLE PHOSPHOLIPID-TRANSPORTING ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13246">
        <property type="entry name" value="Cation_ATPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16212">
        <property type="entry name" value="PhoLip_ATPase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16209">
        <property type="entry name" value="PhoLip_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDF00027">
        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 13 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 14 15" id="KW-0460">Magnesium</keyword>
    <keyword evidence="10 15" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 14" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 13 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 15" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 15 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 15" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="55"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="78"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="291"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="337"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="878"/>
            <end position="898"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="918"/>
            <end position="941"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="962"/>
            <end position="983"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="995"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1026"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="15">
        <location>
            <begin position="1063"/>
            <end position="1087"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase N-terminal" evidence="16">
        <location>
            <begin position="25"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="domain" description="P-type ATPase C-terminal" evidence="17">
        <location>
            <begin position="848"/>
            <end position="1097"/>
        </location>
    </feature>
    <feature type="active site" description="4-aspartylphosphate intermediate" evidence="12">
        <location>
            <position position="407"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="407"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="409"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="510"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="556"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="591"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="626"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="700"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="701"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="795"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="801"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="821"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="824"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="825"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="14">
        <location>
            <position position="825"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008109"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00034036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PIRSR" id="PIRSR606539-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU362033"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF16209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="Pfam" id="PF16212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAK89054.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1178" mass="133819" checksum="6EBE8E6C1D1F8586" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUJ3</accession>
    <name>Q5CUJ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_2610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89061.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626821.1">
        <property type="nucleotide sequence ID" value="XM_626821.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUJ3"/>
    <dbReference type="GeneID" id="3373972"/>
    <dbReference type="KEGG" id="cpv:cgd3_2610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2610"/>
    <dbReference type="InParanoid" id="Q5CUJ3"/>
    <dbReference type="OrthoDB" id="341151at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89061.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="191" mass="22465" checksum="41B55C8DD1DE27B9" modified="2005-04-12" version="1">MDANNIVPENIKHIQQQSLNPTTTLNKKLIFSSNERNNLWDLFSSNFLLFKFYPSGNEIEEELKSIHEMIKVFENWKSLISTKKMSLFDFCKTIEKFTFHTETQDYRLRTVFNYKSIKSGMHSNMSNYEFRPISSKEHTDQRNIVGDQNDDSKSINSNQNLDTSCGIEEKLKAKRELALKRRKLLLTNKVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUL7</accession>
    <name>Q5CUL7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89082.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626797.1">
        <property type="nucleotide sequence ID" value="XM_626797.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUL7"/>
    <dbReference type="GeneID" id="3373922"/>
    <dbReference type="KEGG" id="cpv:cgd3_2300"/>
    <dbReference type="InParanoid" id="Q5CUL7"/>
    <dbReference type="OMA" id="CNEINSM"/>
    <dbReference type="OrthoDB" id="275748at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="343"/>
            <end position="363"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89082.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="460" mass="53331" checksum="A2F8F4A6A53A9A78" modified="2005-04-12" version="1">MYWDKYDEIPLRWISFFLFKWRLELDESFVGGPLLDDFFEKIGSIFYLLLLKRYETNFCDIDTTEVGINLFIDRLPKVLILIGNSGSGKRYFARELLSSFSKICYFENSKSFNPVTFNISIDEYFIDTRTTDCFDKKIYYLNNKLTSISKVGVRLRDSLCSGPFSPPAILVCFRSANPNKYYTGPNSNYYGDVSKQIVILNLISKFIRIWDNKNIPIVSFFISDIDPDDYGTSNKILQSKTMDIRYIFKYGYGEFFEIDFRNFSLQIDKISLLRFLIYKRYDINEISLNCLMEKISSIHSKYIMALSNEELKFIVNEIDLVRIADVLNEELHDIPYTVSCGRFVAIVLNGVIPDFFNVFLYYFNFVIRRLNKSVSNSNCTICDSSCDRESGSCKNGLIQMTGFGQVIHKIKNLLLPCISYSEISNFRLPIVFNEASGIIVFGDKGCGKFYFSQANEKITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUM7</accession>
    <name>Q5CUM7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin domain containing protein with a UBA domain at the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd3_2190</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DDI1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89090.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626787.1">
        <property type="nucleotide sequence ID" value="XM_626787.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUM7"/>
    <dbReference type="FunCoup" id="Q5CUM7">
        <property type="interactions" value="55"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUM7"/>
    <dbReference type="GeneID" id="3374039"/>
    <dbReference type="KEGG" id="cpv:cgd3_2190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2190"/>
    <dbReference type="InParanoid" id="Q5CUM7"/>
    <dbReference type="OrthoDB" id="1047367at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004190">
        <property type="term" value="F:aspartic-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05479">
        <property type="entry name" value="RP_DDI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd14309">
        <property type="entry name" value="UBA_scDdi1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.70.10">
        <property type="entry name" value="Acid Proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.10">
        <property type="entry name" value="DNA helicase RuvA subunit, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019103">
        <property type="entry name" value="Peptidase_aspartic_DDI1-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021109">
        <property type="entry name" value="Peptidase_aspartic_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015940">
        <property type="entry name" value="UBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009060">
        <property type="entry name" value="UBA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397:SF3">
        <property type="entry name" value="DNA DAMAGE INDUCIBLE 1 HOMOLOG 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15397">
        <property type="entry name" value="SODIUM-GLUCOSE COTRANSPORTER REGULATORY PROTEIN -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09668">
        <property type="entry name" value="Asp_protease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00627">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00165">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50630">
        <property type="entry name" value="Acid proteases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46934">
        <property type="entry name" value="UBA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50030">
        <property type="entry name" value="UBA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0064">Aspartyl protease</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UBA" evidence="5">
        <location>
            <begin position="336"/>
            <end position="380"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022750"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50030"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89090.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="384" mass="43423" checksum="83B5E0C52F933EED" modified="2005-04-12" version="1">MKVNIFYSVTGELISVEIHEETTVEVLKSLIEIELNLDSFKNYELSIEGKILKNDGFVLSDIVNEGSIFVLSEKTNKNTFENSNFSLNDRENLIQLLSKELFTKIKEDQSLKSVYYSKSSKYRDSIDKDDIKSFTELIKNDYFSGNLNSISSSSNSSSNLYNLDPLSPEYQRLIEEQVRKQNVEENLILAQDHLPESFTQVHMLYINAEVNGISIKAFVDSGAQTTIMSKKCAEKCNLVRLIDYRFSGIAQGVGTSKIVGKIHVAQMKIGNSFFPFSITVLEESHVDFLFGLDLLKRYQCCIDLHQNALIIGDEKVQFLSESEINSEISQINSNNEYDQCFEQGKKLQLLSLGFSESQVINALRATNGNTELAASLLFSNETFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUU1</accession>
    <name>Q5CUU1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pp2c protein phosphatase 2 C, possible transmembrane domain near N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626723.1">
        <property type="nucleotide sequence ID" value="XM_626723.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUU1"/>
    <dbReference type="STRING" id="353152.Q5CUU1"/>
    <dbReference type="GeneID" id="3374030"/>
    <dbReference type="KEGG" id="cpv:cgd3_1480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1480"/>
    <dbReference type="InParanoid" id="Q5CUU1"/>
    <dbReference type="OMA" id="ETDFIAC"/>
    <dbReference type="OrthoDB" id="420076at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF792">
        <property type="entry name" value="GM14286P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="120"/>
            <end position="600"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="608" mass="69489" checksum="36A5163722F62859" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVC9</accession>
    <name>Q5CVC9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hypothetical apicomplexan conserved protein with possible transmembrane region near the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_4550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89590.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627340.1">
        <property type="nucleotide sequence ID" value="XM_627340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVC9"/>
    <dbReference type="GeneID" id="3374439"/>
    <dbReference type="KEGG" id="cpv:cgd8_4550"/>
    <dbReference type="InParanoid" id="Q5CVC9"/>
    <dbReference type="OMA" id="ECKEREY"/>
    <dbReference type="OrthoDB" id="343943at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="160"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="24"/>
            <end position="81"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="119"/>
            <end position="157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89590.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="218" mass="26551" checksum="E2984B04B2D1F5F5" modified="2005-04-12" version="1">MEKEFEEESKTLKTQILKDVEIYLAKYRDLAMLATEEAKRQQKKAELIKLKTRELTEITCKSFEEKLRSKMQEDLKKYEEATQSAYSKMILKEKSMNIKWNEREKFIEREKKDFEKSILKQAEKRIEEFRRGLMTTQAQLNKEREIFEDMMGNLRERVSYKLIMNIKIFFFFILKLYQFIRFPLNVLNLKKKCIIGLLLHSVWMKMKSQEECKIIMMH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVE8</accession>
    <name>Q5CVE8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">rRNA 2'-O-methyltransferase fibrillarin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">Histone-glutamine methyltransferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd8_4330</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-glutaminyl-[histone H2A] + S-adenosyl-L-methionine = N(5)-methyl-L-glutaminyl-[histone H2A] + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50904"/>
            <dbReference type="Rhea" id="RHEA-COMP:12837"/>
            <dbReference type="Rhea" id="RHEA-COMP:12839"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30011"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:61891"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the methyltransferase superfamily. Fibrillarin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627321.1">
        <property type="nucleotide sequence ID" value="XM_627321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVE8"/>
    <dbReference type="FunCoup" id="Q5CVE8">
        <property type="interactions" value="340"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVE8"/>
    <dbReference type="GeneID" id="3374527"/>
    <dbReference type="KEGG" id="cpv:cgd8_4330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4330"/>
    <dbReference type="InParanoid" id="Q5CVE8"/>
    <dbReference type="OMA" id="WNPNKSK"/>
    <dbReference type="OrthoDB" id="1859733at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031428">
        <property type="term" value="C:box C/D methylation guide snoRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990259">
        <property type="term" value="F:histone H2AQ104 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008649">
        <property type="term" value="F:rRNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000494">
        <property type="term" value="P:box C/D sno(s)RNA 3'-end processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000056">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.150:FF:000001">
        <property type="entry name" value="Fibrillarin like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00351">
        <property type="entry name" value="RNA_methyltransf_FlpA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000692">
        <property type="entry name" value="Fibrillarin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003276">
        <property type="entry name" value="PRK04266.1-2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335:SF17">
        <property type="entry name" value="FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10335">
        <property type="entry name" value="RRNA 2-O-METHYLTRANSFERASE FIBRILLARIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01269">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006540">
        <property type="entry name" value="Nop17p"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00052">
        <property type="entry name" value="FIBRILLARIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM01206">
        <property type="entry name" value="Fibrillarin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 14" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="13">
        <location>
            <begin position="7"/>
            <end position="61"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00015190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00032245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00047568"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK89572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="301" mass="31818" checksum="11F18601473BC69F" modified="2005-04-12" version="1">MSSRGSPFGGRGRGGGGRGGGRGGGGRSPGGGRGGGGRSPGGGRGRGGGKGGRGGGGGMKGGSKVIIVPHRHEGVFMAKGKSDALVTRNMVPGVSIYGEKRVETTDPETNEKIEYRVWNPFRSKLGATIIGGVANMPIKPGAKVLYLGAANGTTVSHVSDMVGPEGSVYAVEFSHRSGRDLTDMAKRRQNIVPIVEDARTPQKYRMLVPMVDVIFSDVAQPDQARIVALNAHLFLKNNGYFIISIKASCVDSTAKPEAVFASEIDKLRAEKCKPKEQLTLEPYHRDHAVVIGVYRPIKKKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVG5</accession>
    <name>Q5CVG5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ELM2 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_4140</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627304.1">
        <property type="nucleotide sequence ID" value="XM_627304.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVG5"/>
    <dbReference type="GeneID" id="3374189"/>
    <dbReference type="KEGG" id="cpv:cgd8_4140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4140"/>
    <dbReference type="InParanoid" id="Q5CVG5"/>
    <dbReference type="OrthoDB" id="343499at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000949">
        <property type="entry name" value="ELM2_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01448">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51156">
        <property type="entry name" value="ELM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ELM2" evidence="3">
        <location>
            <begin position="12"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="29"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="50"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="90"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="102"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="112"/>
            <end position="136"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="136" mass="14890" checksum="3ECBD950A624F475" modified="2005-04-12" version="1">MGESRWMKQTHSKIRVGPEYQAVVPDLIVPEKKTQDKKDTEFGVPNGTKSSSFSSSSSSSSNAARSSIGTNQNHRLKITTQSLATSNKSSRSEKDLSRDSKITTFESSNKPKSSIKTQKTISKTKTNNKTSSKSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVK9</accession>
    <name>Q5CVK9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="20">Acetyl-CoA carboxylase like biotin dependent carboxylase involved in fatty acid biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">cgd8_3680</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>N(6)-biotinyl-L-lysyl-[protein] + hydrogencarbonate + ATP = N(6)-carboxybiotinyl-L-lysyl-[protein] + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13501"/>
            <dbReference type="Rhea" id="RHEA-COMP:10505"/>
            <dbReference type="Rhea" id="RHEA-COMP:10506"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83144"/>
            <dbReference type="ChEBI" id="CHEBI:83145"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.14"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:11308"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:57384"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.4.1.2"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>biotin</name>
            <dbReference type="ChEBI" id="CHEBI:57586"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="2">Lipid metabolism; malonyl-CoA biosynthesis; malonyl-CoA from acetyl-CoA: step 1/1.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89718.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627260.1">
        <property type="nucleotide sequence ID" value="XM_627260.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CVK9"/>
    <dbReference type="FunCoup" id="Q5CVK9">
        <property type="interactions" value="47"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVK9"/>
    <dbReference type="GeneID" id="3374608"/>
    <dbReference type="KEGG" id="cpv:cgd8_3680"/>
    <dbReference type="InParanoid" id="Q5CVK9"/>
    <dbReference type="OMA" id="PTPKGHC"/>
    <dbReference type="OrthoDB" id="196847at2759"/>
    <dbReference type="UniPathway" id="UPA00655">
        <property type="reaction ID" value="UER00711"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003989">
        <property type="term" value="F:acetyl-CoA carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004075">
        <property type="term" value="F:biotin carboxylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006633">
        <property type="term" value="P:fatty acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:2001295">
        <property type="term" value="P:malonyl-CoA biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06850">
        <property type="entry name" value="biotinyl_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.100:FF:000005">
        <property type="entry name" value="Acetyl-CoA carboxylase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1490.20:FF:000003">
        <property type="entry name" value="acetyl-CoA carboxylase isoform X1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.226.10">
        <property type="entry name" value="2-enoyl-CoA Hydratase, Chain A, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.20">
        <property type="entry name" value="ATP-grasp fold, A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.460.10">
        <property type="entry name" value="Biotin dependent carboxylase carboxyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1770.10">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049076">
        <property type="entry name" value="ACCA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034733">
        <property type="entry name" value="AcCoA_carboxyl_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013537">
        <property type="entry name" value="AcCoA_COase_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011761">
        <property type="entry name" value="ATP-grasp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013815">
        <property type="entry name" value="ATP_grasp_subdomain_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005481">
        <property type="entry name" value="BC-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011764">
        <property type="entry name" value="Biotin_carboxylation_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005482">
        <property type="entry name" value="Biotin_COase_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000089">
        <property type="entry name" value="Biotin_lipoyl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029045">
        <property type="entry name" value="ClpP/crotonase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011763">
        <property type="entry name" value="COA_CT_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011762">
        <property type="entry name" value="COA_CT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005479">
        <property type="entry name" value="CPAse_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016185">
        <property type="entry name" value="PreATP-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011054">
        <property type="entry name" value="Rudment_hybrid_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011053">
        <property type="entry name" value="Single_hybrid_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728:SF3">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45728">
        <property type="entry name" value="ACETYL-COA CARBOXYLASE, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08326">
        <property type="entry name" value="ACC_central"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02785">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00289">
        <property type="entry name" value="Biotin_carb_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00364">
        <property type="entry name" value="Biotin_lipoyl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01039">
        <property type="entry name" value="Carboxyl_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02786">
        <property type="entry name" value="CPSase_L_D2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00878">
        <property type="entry name" value="Biotin_carb_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52096">
        <property type="entry name" value="ClpP/crotonase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52440">
        <property type="entry name" value="PreATP-grasp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51246">
        <property type="entry name" value="Rudiment single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51230">
        <property type="entry name" value="Single hybrid motif"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50975">
        <property type="entry name" value="ATP_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50979">
        <property type="entry name" value="BC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50989">
        <property type="entry name" value="COA_CT_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50980">
        <property type="entry name" value="COA_CT_NTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00866">
        <property type="entry name" value="CPSASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00867">
        <property type="entry name" value="CPSASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7 14" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0092">Biotin</keyword>
    <keyword evidence="9" id="KW-0275">Fatty acid biosynthesis</keyword>
    <keyword evidence="6" id="KW-0276">Fatty acid metabolism</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="3" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="8" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="11" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="5 14" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Biotin carboxylation" evidence="17">
        <location>
            <begin position="34"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="domain" description="ATP-grasp" evidence="16">
        <location>
            <begin position="192"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase N-terminal" evidence="18">
        <location>
            <begin position="2023"/>
            <end position="2355"/>
        </location>
    </feature>
    <feature type="domain" description="CoA carboxyltransferase C-terminal" evidence="19">
        <location>
            <begin position="2370"/>
            <end position="2679"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="898"/>
            <end position="925"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1664"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="15">
        <location>
            <begin position="898"/>
            <end position="907"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1670"/>
            <end position="1682"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1695"/>
            <end position="1713"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="1723"/>
            <end position="1732"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="20">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001953"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004956"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023267"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00048600"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00409"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS50975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="PROSITE" id="PS50979"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="PROSITE" id="PS50980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="19">
        <source>
            <dbReference type="PROSITE" id="PS50989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EAK89718.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2733" mass="307071" checksum="AA3C636C55CAA173" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVR5</accession>
    <name>Q5CVR5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Adaptin AP complex subunit alpha</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_3060</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627204.1">
        <property type="nucleotide sequence ID" value="XM_627204.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVR5"/>
    <dbReference type="STRING" id="353152.Q5CVR5"/>
    <dbReference type="GeneID" id="3374318"/>
    <dbReference type="KEGG" id="cpv:cgd8_3060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3060"/>
    <dbReference type="InParanoid" id="Q5CVR5"/>
    <dbReference type="OMA" id="NTGHICI"/>
    <dbReference type="OrthoDB" id="413467at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1230">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008152">
        <property type="entry name" value="Clathrin_a/b/g-adaptin_app_Ig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013041">
        <property type="entry name" value="Clathrin_app_Ig-like_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02883">
        <property type="entry name" value="Alpha_adaptinC2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49348">
        <property type="entry name" value="Clathrin adaptor appendage domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0653">Protein transport</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin adaptor alpha/beta/gamma-adaptin appendage Ig-like subdomain" evidence="3">
        <location>
            <begin position="378"/>
            <end position="476"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02883"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="611" mass="70712" checksum="F9CC1492C50D9B37" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW17</accession>
    <name>Q5CW17_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Arp2/3 complex 41 kDa subunit</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="9">p41-ARC</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd8_1980</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the WD repeat ARPC1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89688.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627102.1">
        <property type="nucleotide sequence ID" value="XM_627102.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW17"/>
    <dbReference type="STRING" id="353152.Q5CW17"/>
    <dbReference type="GeneID" id="3374410"/>
    <dbReference type="KEGG" id="cpv:cgd8_1980"/>
    <dbReference type="InParanoid" id="Q5CW17"/>
    <dbReference type="OMA" id="AVGHDCI"/>
    <dbReference type="OrthoDB" id="406844at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005885">
        <property type="term" value="C:Arp2/3 protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034314">
        <property type="term" value="P:Arp2/3 complex-mediated actin nucleation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017383">
        <property type="entry name" value="ARPC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10709:SF2">
        <property type="entry name" value="ACTIN-RELATED PROTEIN 2_3 COMPLEX SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00041244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00041789"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89688.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="373" mass="42151" checksum="2A59E0182C752823" modified="2005-04-12" version="1" fragment="single">LDFLFFLDISLVCEKRNIKIYQLNGLHPSNSLAKLSKHRNRIVSIDWSLLPTKYSLDSSYSQLVSVGEDRLVIVWLLKVEAEKDSFSEKLVIVSSILNCIQSDCYPTFCRISPFQEFCSFAVSTTSGEVFFFTSKKNSGLENEKTSFSEAKQRDLYVFDQLKIGLSELPLTCLAWSNSSKFLACGGLENKGIILGVSIEDSNFKDENFDENSSETLSLQALSSINSQNAIMACDFSPKGNQIAFTDKDSFLYFTQISKKLEFLNSSLKWNGLPLINLKFVHENLLAAVGHDCIPVLFMQTNGCMWTHATTLNGAILPNYLDPVWQLNFDPIKHYTQNSVHKRPIMKVLVPNPSTLVCYGFDGKYSIWELESHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW20</accession>
    <name>Q5CW20_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Shares a domain with a conserved HREF motif with the CWF15 protein that is involved in mRNA splicing</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_1950</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CWC15 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89397.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627099.1">
        <property type="nucleotide sequence ID" value="XM_627099.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW20"/>
    <dbReference type="STRING" id="353152.Q5CW20"/>
    <dbReference type="GeneID" id="3374471"/>
    <dbReference type="KEGG" id="cpv:cgd8_1950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1950"/>
    <dbReference type="InParanoid" id="Q5CW20"/>
    <dbReference type="OMA" id="DIRYHEI"/>
    <dbReference type="OrthoDB" id="30179at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006973">
        <property type="entry name" value="Cwf_Cwc_15"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN CWF15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12718:SF2">
        <property type="entry name" value="SPLICEOSOME-ASSOCIATED PROTEIN CWC15 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04889">
        <property type="entry name" value="Cwf_Cwc_15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="3" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="85"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="145"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="91"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="154"/>
            <end position="164"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006644"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89397.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="214" mass="25718" checksum="049370F206D019A7" modified="2005-04-12" version="1">MNGHSVNRYTIESRKLHKSDQRGHLTLKYRRDNNETKKNESVIRIDRDIKQYSGTNFASNEKSDSSNFEVSDDNQIVKETTHLSPTKDELLESEGELELELESGSEKEELDDDEELLKELEKIKKERVEREKEKKNNDIKLMMQNNPLLEEYNESDRDKVDHDESDREEYILKKRWTEDTVFRNQNRVSQPKKRFINDILHSDQHREFMRKYIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWB5</accession>
    <name>Q5CWB5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_960</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627004.1">
        <property type="nucleotide sequence ID" value="XM_627004.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWB5"/>
    <dbReference type="GeneID" id="3374422"/>
    <dbReference type="KEGG" id="cpv:cgd8_960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_960"/>
    <dbReference type="InParanoid" id="Q5CWB5"/>
    <dbReference type="OMA" id="FEITISA"/>
    <dbReference type="OrthoDB" id="446247at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916">
        <property type="entry name" value="CYSTEINE AND GLYCINE-RICH PROTEIN 2 BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20916:SF18">
        <property type="entry name" value="IPT_TIG DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="387"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="421"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="477"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="505"/>
            <end position="525"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="531"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="607"/>
            <end position="628"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="679" mass="79035" checksum="7E8EA3B1FE7AF658" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWL1</accession>
    <name>Q5CWL1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4640</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90052.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627793.1">
        <property type="nucleotide sequence ID" value="XM_627793.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWL1"/>
    <dbReference type="GeneID" id="3375797"/>
    <dbReference type="KEGG" id="cpv:cgd6_4640"/>
    <dbReference type="InParanoid" id="Q5CWL1"/>
    <dbReference type="OrthoDB" id="205108at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255032" evidence="1">
        <location>
            <begin position="23"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90052.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="125" mass="15183" checksum="95FCD30E73D077A0" modified="2005-04-12" version="1">MVQTILKVFYILSFVGISFNQATVSKINGDENYFKFSYLQDWMPEWTRNNDRYLFNTLYYDQENNEDDEFELGTTETKQIQCRIVILTAGDEDFNTLVELERNRIEYSRKQKYCYLHFFCKKTKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWN3</accession>
    <name>Q5CWN3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">proline--tRNA ligase</fullName>
            <ecNumber evidence="1">6.1.1.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Prolyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_4400</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="journal article" date="2017" name="Structure" volume="25" first="1495" last="1505.e6">
            <title>Targeting Prolyl-tRNA Synthetase to Accelerate Drug Discovery against Malaria, Leishmaniasis, Toxoplasmosis, Cryptosporidiosis, and Coccidiosis.</title>
            <authorList>
                <person name="Jain V."/>
                <person name="Yogavel M."/>
                <person name="Kikuchi H."/>
                <person name="Oshima Y."/>
                <person name="Hariguchi N."/>
                <person name="Matsumoto M."/>
                <person name="Goel P."/>
                <person name="Touquet B."/>
                <person name="Jumani R.S."/>
                <person name="Tacchini-Cottier F."/>
                <person name="Harlos K."/>
                <person name="Huston C.D."/>
                <person name="Hakimi M.A."/>
                <person name="Sharma A."/>
            </authorList>
            <dbReference type="PubMed" id="28867614"/>
            <dbReference type="DOI" id="10.1016/j.str.2017.07.015"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.46 ANGSTROMS) OF 225-719 IN COMPLEX WITH ZN(2+)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>tRNA(Pro) + L-proline + ATP = L-prolyl-tRNA(Pro) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:14305"/>
            <dbReference type="Rhea" id="RHEA-COMP:9700"/>
            <dbReference type="Rhea" id="RHEA-COMP:9702"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:60039"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78532"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.15"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.15" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627771.1">
        <property type="nucleotide sequence ID" value="XM_627771.1"/>
    </dbReference>
    <dbReference type="PDB" id="5XIO">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.46 A"/>
        <property type="chains" value="A/B=225-719"/>
    </dbReference>
    <dbReference type="PDBsum" id="5XIO"/>
    <dbReference type="AlphaFoldDB" id="Q5CWN3"/>
    <dbReference type="SMR" id="Q5CWN3"/>
    <dbReference type="FunCoup" id="Q5CWN3">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWN3"/>
    <dbReference type="GeneID" id="3375909"/>
    <dbReference type="KEGG" id="cpv:cgd6_4400"/>
    <dbReference type="InParanoid" id="Q5CWN3"/>
    <dbReference type="OMA" id="EVYWVTH"/>
    <dbReference type="OrthoDB" id="1350766at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002161">
        <property type="term" value="F:aminoacyl-tRNA deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004827">
        <property type="term" value="F:proline-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006433">
        <property type="term" value="P:prolyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00862">
        <property type="entry name" value="ProRS_anticodon_zinc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00778">
        <property type="entry name" value="ProRS_core_arch_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.110.30:FF:000001">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000007">
        <property type="entry name" value="Bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.800:FF:000005">
        <property type="entry name" value="bifunctional glutamate/proline--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.110.30">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.960.10">
        <property type="entry name" value="YbaK/aminoacyl-tRNA synthetase-associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01571">
        <property type="entry name" value="Pro_tRNA_synth_type3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002316">
        <property type="entry name" value="Pro-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004499">
        <property type="entry name" value="Pro-tRNA-ligase_IIa_arc-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016061">
        <property type="entry name" value="Pro-tRNA_ligase_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017449">
        <property type="entry name" value="Pro-tRNA_synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033721">
        <property type="entry name" value="ProRS_core_arch_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036754">
        <property type="entry name" value="YbaK/aa-tRNA-synt-asso_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007214">
        <property type="entry name" value="YbaK/aa-tRNA-synth-assoc-dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00408">
        <property type="entry name" value="proS_fam_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382:SF2">
        <property type="entry name" value="BIFUNCTIONAL GLUTAMATE_PROLINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43382">
        <property type="entry name" value="PROLYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09180">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04073">
        <property type="entry name" value="tRNA_edit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01046">
        <property type="entry name" value="TRNASYNTHPRO"/>
    </dbReference>
    <dbReference type="SMART" id="SM00946">
        <property type="entry name" value="ProRS-C_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64586">
        <property type="entry name" value="C-terminal domain of ProRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55826">
        <property type="entry name" value="YbaK/ProRS associated domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="6 10" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="12" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="9">
        <location>
            <begin position="266"/>
            <end position="504"/>
        </location>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="652"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="657"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="12">
        <location>
            <position position="702"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00029731"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="5XIO"/>
        </source>
    </evidence>
    <sequence length="719" mass="82942" checksum="757C2922616AAB06" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWR1</accession>
    <name>Q5CWR1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90012.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627743.1">
        <property type="nucleotide sequence ID" value="XM_627743.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWR1"/>
    <dbReference type="STRING" id="353152.Q5CWR1"/>
    <dbReference type="GeneID" id="3375757"/>
    <dbReference type="KEGG" id="cpv:cgd6_4090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4090"/>
    <dbReference type="InParanoid" id="Q5CWR1"/>
    <dbReference type="OrthoDB" id="342668at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="239"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="239"/>
            <end position="252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="261"/>
            <end position="271"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90012.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="343" mass="39606" checksum="AD29B8E535206BE3" modified="2007-04-03" version="1">MEFFIRSEIIKNEENNTVKSLLKNLLEMLELAFQESIMNIDGLVEQQIRNLERYERFIGSTKLLEEVSIHDARKIVHIGHPKYKLNDIVNKASKLRDSLKGNGMDSLGIIRFNNPNHLTDSNKNAKNFSINQITENKNEENLTLDLLLFEETQSYEERYLISNEIHDYYCYGNHEYNLFFNNFYKDYELGILEEFNTHNFDIDLNIDSNSNSIYKIESNPSSNSNSGLEIEEIPIPHQSFGSSSSLESSPYSQYKPKSQTNYNLDSNSNSEENISHSWSTVLTPQNTKISEESSDRFVNRSISKLKPDQKEIISIDKGKESPDVLKAIGYCHTSSFYTVKSLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWX8</accession>
    <name>Q5CWX8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627676.1">
        <property type="nucleotide sequence ID" value="XM_627676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWX8"/>
    <dbReference type="GeneID" id="3375701"/>
    <dbReference type="KEGG" id="cpv:cgd6_3310"/>
    <dbReference type="InParanoid" id="Q5CWX8"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="55"/>
            <end position="134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="204" mass="24858" checksum="905934BC3E9A4382" modified="2005-04-12" version="1">MEVLIRKTSKYKKFLAIKDPSKQIYGPKMLEKMRNMCSRFEDIDEIFEEQLNPIYESVEAEYNRKLLEMDQEERRRKEEEFKRKVQQGIQETYLEEKRRLEKLKEKQEEEKRRKEALERLNQEEKERLEKMNRNIEIMSIFIKELETGEVLNEFKDTQVYSKLEIYEFKIIGIGILLLLRQELDLKEFYTCIGLVSDLLVSILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX11</accession>
    <name>Q5CX11_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">C3H1-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2950</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89927.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627643.1">
        <property type="nucleotide sequence ID" value="XM_627643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX11"/>
    <dbReference type="GeneID" id="3375672"/>
    <dbReference type="KEGG" id="cpv:cgd6_2950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2950"/>
    <dbReference type="InParanoid" id="Q5CX11"/>
    <dbReference type="OrthoDB" id="342143at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="530"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="786"/>
            <end position="805"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="531"/>
            <end position="564"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="788"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89927.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="938" mass="99600" checksum="2C103465B456D5C6" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX26</accession>
    <name>Q5CX26_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2780</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627628.1">
        <property type="nucleotide sequence ID" value="XM_627628.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX26"/>
    <dbReference type="GeneID" id="3376153"/>
    <dbReference type="KEGG" id="cpv:cgd6_2780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2780"/>
    <dbReference type="InParanoid" id="Q5CX26"/>
    <dbReference type="OMA" id="HELWNRS"/>
    <dbReference type="OrthoDB" id="338819at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="454"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="636"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="471"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="647"/>
            <end position="657"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="732" mass="83791" checksum="ED676ECF98D2288D" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX71</accession>
    <name>Q5CX71_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_2260</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89877.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627583.1">
        <property type="nucleotide sequence ID" value="XM_627583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX71"/>
    <dbReference type="FunCoup" id="Q5CX71">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX71"/>
    <dbReference type="GeneID" id="3376175"/>
    <dbReference type="KEGG" id="cpv:cgd6_2260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2260"/>
    <dbReference type="InParanoid" id="Q5CX71"/>
    <dbReference type="OMA" id="DRICVEM"/>
    <dbReference type="OrthoDB" id="10259640at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025313">
        <property type="entry name" value="SPB4-like_CTE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13959">
        <property type="entry name" value="CTE_SPB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01178">
        <property type="entry name" value="DUF4217"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 11" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="10">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="102"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="308"/>
            <end position="480"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="71"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89877.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="770" mass="88262" checksum="543844381D12EFC4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX77</accession>
    <name>Q5CX77_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TBC domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2190</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89871.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627577.1">
        <property type="nucleotide sequence ID" value="XM_627577.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX77"/>
    <dbReference type="FunCoup" id="Q5CX77">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX77"/>
    <dbReference type="GeneID" id="3376169"/>
    <dbReference type="KEGG" id="cpv:cgd6_2190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2190"/>
    <dbReference type="InParanoid" id="Q5CX77"/>
    <dbReference type="OMA" id="DTMIQDS"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000016">
        <property type="entry name" value="TBC1 domain family member 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.750">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF20">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER 2B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="141"/>
            <end position="342"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89871.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="408" mass="47324" checksum="9708A9C86EE472A0" modified="2007-04-03" version="1">MDVDLPIFEFTLKNLEKKELNNLADNKIGVTENNPDECDISVRLENICWKSQCYVDILPLDFCDVNHSLLNETNSRKTVGMGWELQRKLTKLGYNNFNKYLISNYINLFPIGISKSKAKLCNWANYKDFTQKKLLKLCINGIPSDIRGEVWCYLLGSDRMLRNNSNVYFNELNGSIDKNIENQIILDLHRTFPNSKYYSNSSNFNKVGTLSRVLYAFASYDKAIGYCQSMNFIAAILLINMKEEAAFWSLVQLVSSNRNKEFMVCSWGDLETYYGERMDGVIRDIAILETLCRQFIPKVSQKLENIGVNFQWFALEWFLCFFVTSLPLKSIMEILDLIFCFGSDVLFNISIALLDINKKKLLSSVNMEECMEILKNITRNITDSTKIIRKAMKYNISSNHIRKLREEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX80</accession>
    <name>Q5CX80_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89869.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627574.1">
        <property type="nucleotide sequence ID" value="XM_627574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX80"/>
    <dbReference type="GeneID" id="3376167"/>
    <dbReference type="KEGG" id="cpv:cgd6_2160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2160"/>
    <dbReference type="InParanoid" id="Q5CX80"/>
    <dbReference type="OrthoDB" id="341389at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="197"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="198"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89869.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="218" mass="25493" checksum="A223854CE748C710" modified="2007-04-03" version="1">MNYDEIRSLILDTAEEYKHSLGSDYRLVLKEINQLGDISVSDSFQKNKVEFSFSLKKGKEKYKISIYVNRKLLESNESLIGNKHLKKSVEISALAFWEFSDKKKELFEYFTELFEEDGISPFKNSESHDIFYSNCEGLRDELIPSCDIISFLDIFLLSLFRSKIPQLIRHLGWDESIPLRNSLIEHIASDECFKDLDESSTDSESEESTVKKRVNRRY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX81</accession>
    <name>Q5CX81_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">16S rRNA (uracil(1498)-N(3))-methyltransferase</fullName>
            <ecNumber evidence="3">2.1.1.193</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_2130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>uridine(1498) in 16S rRNA + S-adenosyl-L-methionine = N(3)-methyluridine(1498) in 16S rRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:42920"/>
            <dbReference type="Rhea" id="RHEA-COMP:10283"/>
            <dbReference type="Rhea" id="RHEA-COMP:10284"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:65315"/>
            <dbReference type="ChEBI" id="CHEBI:74502"/>
            <dbReference type="EC" id="2.1.1.193"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the RNA methyltransferase RsmE family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.193" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627573.1">
        <property type="nucleotide sequence ID" value="XM_627573.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX81"/>
    <dbReference type="STRING" id="353152.Q5CX81"/>
    <dbReference type="GeneID" id="3375998"/>
    <dbReference type="KEGG" id="cpv:cgd6_2130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2130"/>
    <dbReference type="InParanoid" id="Q5CX81"/>
    <dbReference type="OMA" id="WQTPFLE"/>
    <dbReference type="OrthoDB" id="2021042at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070042">
        <property type="term" value="F:rRNA (uridine-N3-)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18084">
        <property type="entry name" value="RsmE-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006700">
        <property type="entry name" value="RsmE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046886">
        <property type="entry name" value="RsmE_MTase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00046">
        <property type="entry name" value="RsmE family RNA methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027:SF3">
        <property type="entry name" value="16S RRNA (URACIL(1498)-N(3))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR30027">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04452">
        <property type="entry name" value="Methyltrans_RNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Ribosomal RNA small subunit methyltransferase E methyltransferase" evidence="11">
        <location>
            <begin position="172"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="336"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005528"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00025699"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047944"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF04452"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="336" mass="37775" checksum="BBFD8A932E64E1FD" modified="2005-04-12" version="1" fragment="single">MIFQYETQSFVSLVLLCDRIFLMHHARRSSLNADHTAIMVIFPSILMNLIIIDKKDINEDLTVELSSRQSNHCISVLEINIGSKVNVGVKNSGKGTATVTKIMRKETNKDGITKSESIINLSSIEEIGNKVNNRSRRSISEINNLNNFQYAVTIKLDTEIHKEEYKHDYPLIDLLIALPRPKVFEKVLQNAVTIGVGRIIFVCTDKSEKSYLNSSKLKKESIDEIVQLGLEQASKTLCPDVYVYASWTFFLQHLRNYFFCKESMIGIVADVLGNSKITEIGLQSHTGPIILAIGPEGGWTKEELTDLITMGFKVVNMGDRILKVETALISLYSKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX87</accession>
    <name>Q5CX87_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Adaptin AP complex subunit alpha ARM repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_2070</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627567.1">
        <property type="nucleotide sequence ID" value="XM_627567.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX87"/>
    <dbReference type="STRING" id="353152.Q5CX87"/>
    <dbReference type="GeneID" id="3375879"/>
    <dbReference type="KEGG" id="cpv:cgd6_2070"/>
    <dbReference type="InParanoid" id="Q5CX87"/>
    <dbReference type="OMA" id="ERISTFC"/>
    <dbReference type="OrthoDB" id="413467at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050840">
        <property type="entry name" value="Adaptor_Complx_Large_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22780">
        <property type="entry name" value="ADAPTIN, ALPHA/GAMMA/EPSILON"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="5">
        <location>
            <begin position="17"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1106" mass="127623" checksum="5A6E3E1FEFF8CC92" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXA5</accession>
    <name>Q5CXA5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Cyclin M2-like membrane-associated protein with 4 transmembrane domains and 2 CBS domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_1840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89851.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627549.1">
        <property type="nucleotide sequence ID" value="XM_627549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXA5"/>
    <dbReference type="STRING" id="353152.Q5CXA5"/>
    <dbReference type="GeneID" id="3376063"/>
    <dbReference type="KEGG" id="cpv:cgd6_1840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1840"/>
    <dbReference type="InParanoid" id="Q5CXA5"/>
    <dbReference type="OMA" id="EEHTYKK"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030026">
        <property type="term" value="P:intracellular manganese ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.580.10:FF:000006">
        <property type="entry name" value="DUF21 and CBS domain protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.580.10">
        <property type="entry name" value="CBS-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000644">
        <property type="entry name" value="CBS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046342">
        <property type="entry name" value="CBS_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF97">
        <property type="entry name" value="METAL TRANSPORTER CNNM-5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54631">
        <property type="entry name" value="CBS-domain pair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51371">
        <property type="entry name" value="CBS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0129">CBS domain</keyword>
    <keyword evidence="5 7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="62"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="123"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="149"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="180"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="10">
        <location>
            <begin position="60"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="domain" description="CBS" evidence="9">
        <location>
            <begin position="423"/>
            <end position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00703"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51371"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89851.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="572" mass="64656" checksum="815563B03C0ABC2D" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXD0</accession>
    <name>Q5CXD0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Apyrase calcium-activated nucleotidase SCAN-1-like protein signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd6_1570</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1 6">
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the apyrase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89829.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627524.1">
        <property type="nucleotide sequence ID" value="XM_627524.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXD0"/>
    <dbReference type="STRING" id="353152.Q5CXD0"/>
    <dbReference type="GeneID" id="3376108"/>
    <dbReference type="KEGG" id="cpv:cgd6_1570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1570"/>
    <dbReference type="InParanoid" id="Q5CXD0"/>
    <dbReference type="OMA" id="ATNLMLC"/>
    <dbReference type="OrthoDB" id="25028at2759"/>
    <dbReference type="BRENDA" id="3.6.1.5">
        <property type="organism ID" value="1728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004382">
        <property type="term" value="F:GDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045134">
        <property type="term" value="F:UDP phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030166">
        <property type="term" value="P:proteoglycan biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="2.120.10.100:FF:000003">
        <property type="entry name" value="Apyrase calcium-activated nucleotidase SCAN-1-like protein signal peptide"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.120.10.100">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009283">
        <property type="entry name" value="Apyrase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036258">
        <property type="entry name" value="Apyrase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023">
        <property type="entry name" value="APYRASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13023:SF3">
        <property type="entry name" value="SOLUBLE CALCIUM-ACTIVATED NUCLEOTIDASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06079">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101887">
        <property type="entry name" value="Apyrase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="7">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254338" evidence="7">
        <location>
            <begin position="23"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="108"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="225"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="286"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="340"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001913"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025738"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRSR" id="PIRSR609283-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89829.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="345" mass="39368" checksum="1F5A8986767E3B90" modified="2007-04-03" version="1">MKESSTINYLITLTFIIPFVLSQSTLLNLGAGGAQERRVCTDEMPCNFRLVADLDMNSKPGNGEKNYKSLFQKGSIIQDKRGNYRVDWGEILELKSGYNEYGRGMELSELISYNGMMLAGDDRTGIIFEITDDGKGVAPRYILSEGNGRTAKGMKIEWFAVRDGILWVGSFGKEFVSNGIIEKRDNMWVATIDKRGHVSRFNWSFVYEKIRNSLGAQYPGYCIHEAVIWSHLMRKWIFLPRRVSFDEYDEEKDEKRGSNKMIIMTDDFEILEIIDVGLIIPERGFSSLKFLPGSFDQIIVATKSVEESISDTQKSFLTIFTINGKILMEDLEVPGDYKYEGIEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXG4</accession>
    <name>Q5CXG4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Large protein with signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_1180</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89802.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627490.1">
        <property type="nucleotide sequence ID" value="XM_627490.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXG4"/>
    <dbReference type="GeneID" id="3376034"/>
    <dbReference type="KEGG" id="cpv:cgd6_1180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1180"/>
    <dbReference type="InParanoid" id="Q5CXG4"/>
    <dbReference type="OMA" id="NDICNIA"/>
    <dbReference type="OrthoDB" id="337201at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89802.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2408" mass="281576" checksum="59308E4BE20CA753" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXI7</accession>
    <name>Q5CXI7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Pescadillo homolog</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_940</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleolus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
            <location evidence="4">Nucleoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the pescadillo family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89781.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627467.1">
        <property type="nucleotide sequence ID" value="XM_627467.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXI7"/>
    <dbReference type="FunCoup" id="Q5CXI7">
        <property type="interactions" value="548"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXI7"/>
    <dbReference type="GeneID" id="3376091"/>
    <dbReference type="KEGG" id="cpv:cgd6_940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_940"/>
    <dbReference type="InParanoid" id="Q5CXI7"/>
    <dbReference type="OMA" id="QKVTWIV"/>
    <dbReference type="OrthoDB" id="10264910at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd17709">
        <property type="entry name" value="BRCT_pescadillo_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03028">
        <property type="entry name" value="Pescadillo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010613">
        <property type="entry name" value="PES"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221">
        <property type="entry name" value="PESCADILLO - RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12221:SF6">
        <property type="entry name" value="PESCADILLO HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00533">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06732">
        <property type="entry name" value="Pescadillo_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00292">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50172">
        <property type="entry name" value="BRCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 4" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="2 4" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="BRCT" evidence="6">
        <location>
            <begin position="282"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="409"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="453"/>
            <end position="516"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="420"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="474"/>
            <end position="483"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="499"/>
            <end position="508"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89781.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="548" mass="63635" checksum="E2C62FB5510F26E5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXJ9</accession>
    <name>Q5CXJ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Swift like BRCT domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_810</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89770.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627455.1">
        <property type="nucleotide sequence ID" value="XM_627455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXJ9"/>
    <dbReference type="STRING" id="353152.Q5CXJ9"/>
    <dbReference type="GeneID" id="3376080"/>
    <dbReference type="KEGG" id="cpv:cgd6_810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_810"/>
    <dbReference type="InParanoid" id="Q5CXJ9"/>
    <dbReference type="OMA" id="CENGEFF"/>
    <dbReference type="OrthoDB" id="342264at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006974">
        <property type="term" value="P:DNA damage response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22665">
        <property type="entry name" value="FHA_MDC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10190">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001357">
        <property type="entry name" value="BRCT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036420">
        <property type="entry name" value="BRCT_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051579">
        <property type="entry name" value="DDR_Transcriptional_Reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196">
        <property type="entry name" value="PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23196:SF1">
        <property type="entry name" value="PAX-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16770">
        <property type="entry name" value="RTT107_BRCT_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52113">
        <property type="entry name" value="BRCT domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="BRCT" evidence="5">
        <location>
            <begin position="233"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="182"/>
            <end position="220"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF16770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89770.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="419" mass="48243" checksum="D06807284E1E8029" modified="2005-04-12" version="1">MYIRSESEEELKHGEEIDEVGCLLIFDETYKSVIDSFPLNEGKNYVCGSTRSVFEPINEKSKKRAKNTKFKGNSKINNEDYHAIIYVEHGEFFVEDNNTDIGTFRKNLKYKIQPNCKYELIPGEDLYFGNLKTKLIRYDSMDSIETPRWKRHSIENNDNNHHQIQLENIEESPKTNHIEDIDLNKSKKKSLGNESTSTLNDDIENDSLLSNRPKRKSPKCIKDEKMNNLPLLKSNNTDKVILLWTGCTPTSKDMELIKRANITSIDSEDLEFMSDQVTHVVSSSIKRTLKFLWAISKGLPIISPSTLRNILNSNRNKDLSYNEFNDLCMNQLLSDLEGEKKFGFSLKNSICKAQNNIPIFNNYKFVISPNIKVPSISEISWLLKSSNAEIIQFEKANKIQDKSNLIFIGTVLDSNKLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXL7</accession>
    <name>Q5CXL7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Pch2p like AAA ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_550</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family. PCH2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89759.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627437.1">
        <property type="nucleotide sequence ID" value="XM_627437.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXL7"/>
    <dbReference type="FunCoup" id="Q5CXL7">
        <property type="interactions" value="50"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXL7"/>
    <dbReference type="GeneID" id="3376049"/>
    <dbReference type="KEGG" id="cpv:cgd6_550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_550"/>
    <dbReference type="InParanoid" id="Q5CXL7"/>
    <dbReference type="OMA" id="VCIHENI"/>
    <dbReference type="OrthoDB" id="10042665at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005694">
        <property type="term" value="C:chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051598">
        <property type="term" value="P:meiotic recombination checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044539">
        <property type="entry name" value="Pch2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058249">
        <property type="entry name" value="Pch2_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45991:SF1">
        <property type="entry name" value="PACHYTENE CHECKPOINT PROTEIN 2 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23242">
        <property type="entry name" value="AAA_lid_TRIP13_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0469">Meiosis</keyword>
    <keyword evidence="2 5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="273"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007271"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023254"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89759.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="546" mass="63619" checksum="06365DADBB83ED8C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="124" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXM0</accession>
    <name>Q5CXM0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">Ser/Thr protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd6_520</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="1">Monomer.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89756.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627434.1">
        <property type="nucleotide sequence ID" value="XM_627434.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXM0"/>
    <dbReference type="STRING" id="353152.Q5CXM0"/>
    <dbReference type="GeneID" id="3376046"/>
    <dbReference type="KEGG" id="cpv:cgd6_520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_520"/>
    <dbReference type="InParanoid" id="Q5CXM0"/>
    <dbReference type="OMA" id="FPNQQYN"/>
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    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000571">
        <property type="entry name" value="Maternal embryonic leucine zipper kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030616">
        <property type="entry name" value="Aur-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24350">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE IAL-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 8 10" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 13" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 8 10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="12">
        <location>
            <begin position="379"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="668"/>
            <end position="716"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="824"/>
            <end position="873"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1035"/>
            <end position="1062"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="1075"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="324"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="669"/>
            <end position="711"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="11">
        <location>
            <begin position="827"/>
            <end position="836"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="837"/>
            <end position="860"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1035"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="1076"/>
            <end position="1089"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="7">
        <location>
            <position position="498"/>
        </location>
    </feature>
    <feature type="binding site" evidence="8 10">
        <location>
            <position position="408"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <begin position="502"/>
            <end position="503"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="519"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="cross-link" description="Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)" evidence="9">
        <location>
            <position position="500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR630616-3"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK89756.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1103" mass="124342" checksum="D652ADCC4D238ADC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXW3</accession>
    <name>Q5CXW3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">RF-C paralog (Ctf18p) AAA+ ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_4690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90439.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_628615.1"/>
    </dbReference>
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    <dbReference type="STRING" id="353152.Q5CXW3"/>
    <dbReference type="GeneID" id="3372193"/>
    <dbReference type="KEGG" id="cpv:cgd7_4690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4690"/>
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    <dbReference type="OMA" id="MANQFRY"/>
    <dbReference type="OrthoDB" id="2195431at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00009">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18140">
        <property type="entry name" value="HLD_clamp_RFC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047854">
        <property type="entry name" value="RFC_lid"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23389:SF3">
        <property type="entry name" value="CHROMOSOME TRANSMISSION FIDELITY PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0235">DNA replication</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="309"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90439.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="914" mass="104655" checksum="A435BCC818A9C91F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY40</accession>
    <name>Q5CY40_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cyclin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90371.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628540.1">
        <property type="nucleotide sequence ID" value="XM_628538.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY40"/>
    <dbReference type="STRING" id="353152.Q5CY40"/>
    <dbReference type="GeneID" id="3372126"/>
    <dbReference type="KEGG" id="cpv:cgd7_3780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3780"/>
    <dbReference type="InParanoid" id="Q5CY40"/>
    <dbReference type="OrthoDB" id="337735at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019901">
        <property type="term" value="F:protein kinase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd20558">
        <property type="entry name" value="CYCLIN_ScPCL7-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013922">
        <property type="entry name" value="Cyclin_PHO80-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15615:SF108">
        <property type="entry name" value="PROTEIN CNPPD1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08613">
        <property type="entry name" value="Cyclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90371.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="596" mass="67324" checksum="5A25305F79EFBFB6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY46</accession>
    <name>Q5CY46_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">LRR protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628534.1">
        <property type="nucleotide sequence ID" value="XM_628532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY46"/>
    <dbReference type="STRING" id="353152.Q5CY46"/>
    <dbReference type="GeneID" id="3372120"/>
    <dbReference type="KEGG" id="cpv:cgd7_3710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3710"/>
    <dbReference type="InParanoid" id="Q5CY46"/>
    <dbReference type="OMA" id="IMANHIC"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057207">
        <property type="entry name" value="FBXL15_LRR"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006553">
        <property type="entry name" value="Leu-rich_rpt_Cys-con_subtyp"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25372">
        <property type="entry name" value="DUF7885"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00367">
        <property type="entry name" value="LRR_CC"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box/LRR-repeat protein 15-like leucin rich repeat" evidence="1">
        <location>
            <begin position="175"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF25372"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="668" mass="76225" checksum="97145683C8D21A4F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY65</accession>
    <name>Q5CY65_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_3520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90634.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628515.1">
        <property type="nucleotide sequence ID" value="XM_628513.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY65"/>
    <dbReference type="STRING" id="353152.Q5CY65"/>
    <dbReference type="GeneID" id="3371982"/>
    <dbReference type="KEGG" id="cpv:cgd7_3520"/>
    <dbReference type="InParanoid" id="Q5CY65"/>
    <dbReference type="OMA" id="VEYMFGR"/>
    <dbReference type="OrthoDB" id="2146at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0097526">
        <property type="term" value="C:spliceosomal tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005689">
        <property type="term" value="C:U12-type spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044641">
        <property type="entry name" value="Lsm7/SmG-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10553:SF5">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="3">
        <location>
            <begin position="19"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90634.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="73" mass="8284" checksum="FF8A8FD7B15C9700" modified="2005-04-12" version="1" fragment="single">KLVPLAKYYLSFNIEMSSKSILGLNKFNNKEIKVKLCGGREVIGILRGFDAVTNLVLDETVEYMFGRLLILFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY78</accession>
    <name>Q5CY78_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative secreted cysteine rich protein, possible transmembrane domain near C, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90337.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628502.1">
        <property type="nucleotide sequence ID" value="XM_628500.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY78"/>
    <dbReference type="GeneID" id="3372052"/>
    <dbReference type="KEGG" id="cpv:cgd7_3380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3380"/>
    <dbReference type="InParanoid" id="Q5CY78"/>
    <dbReference type="OMA" id="FNCCIVQ"/>
    <dbReference type="OrthoDB" id="343433at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="193"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90337.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="208" mass="21618" checksum="93E44F22EF0FC293" modified="2005-04-12" version="1">MKFYARLIILHYIYFVEIINHIFVEALVNDAICNVASGIMVKEACSAVTNAACSTVGTVACQTAGDIACQAMGEAICQTTGNIASDAVCHTACQIASNTAGEAVCNIVSQISSDSVCATACQVASTVIGQSSSDILAGFGAEITSSLISKSASSQLMAASAAANSVTISVTISTVMSILQVMISLFGMGFNLYTHIRSLNARRPYYVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY91</accession>
    <name>Q5CY91_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane protein with no close homologs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_3250</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90330.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628489.1">
        <property type="nucleotide sequence ID" value="XM_628487.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY91"/>
    <dbReference type="GeneID" id="3372045"/>
    <dbReference type="KEGG" id="cpv:cgd7_3250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3250"/>
    <dbReference type="InParanoid" id="Q5CY91"/>
    <dbReference type="OMA" id="ICITQFI"/>
    <dbReference type="OrthoDB" id="340786at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="119"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="179"/>
            <end position="198"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="244"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90330.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="263" mass="29859" checksum="93126EB0CFC27031" modified="2005-04-12" version="1">MATIEMDSVEGFQLKHGSLIGGARKGCLCLSLRLSVFLHGLLNIILLFLTISVLFSIPISLLGSNQEEVLPSGSSHFEVLNRFGLNAVNLMNKYLPRDLLLIITEIIRFIRGSTIEGKFVAFTLDISILSSLVSIFGVFSKSKGLIKFSIFAFLISQLLTIFGIFYAPTLGKLYNLKVLSNPVLLLSILILVMFYTMWYSHLLYSYYKVLRAGGSGGEYLSYREIIDRRNFLRWKTWKERELERGSPYNPSFSRSSEKDRLLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYE9</accession>
    <name>Q5CYE9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Low complexity protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90278.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628431.1">
        <property type="nucleotide sequence ID" value="XM_628429.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3371926"/>
    <dbReference type="KEGG" id="cpv:cgd7_2600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2600"/>
    <dbReference type="InParanoid" id="Q5CYE9"/>
    <dbReference type="OMA" id="ISHTEYL"/>
    <dbReference type="OrthoDB" id="341566at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1152"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1441"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1164"/>
            <end position="1188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1442"/>
            <end position="1459"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90278.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1472" mass="166534" checksum="57EF4848B72178A5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYP4</accession>
    <name>Q5CYP4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_1550</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628336.1">
        <property type="nucleotide sequence ID" value="XM_628334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYP4"/>
    <dbReference type="STRING" id="353152.Q5CYP4"/>
    <dbReference type="GeneID" id="3372253"/>
    <dbReference type="KEGG" id="cpv:cgd7_1550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1550"/>
    <dbReference type="InParanoid" id="Q5CYP4"/>
    <dbReference type="OMA" id="THEYGPH"/>
    <dbReference type="OrthoDB" id="372810at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="68"/>
            <end position="105"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="147"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="198"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="435"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="481"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="592"/>
            <end position="672"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="159"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="226"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="349"/>
            <end position="373"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="443"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="592"/>
            <end position="602"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="626"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="639"/>
            <end position="651"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="840" mass="91668" checksum="9B1F6CE0EFE0245B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYR2</accession>
    <name>Q5CYR2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_1340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90189.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628318.1">
        <property type="nucleotide sequence ID" value="XM_628316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYR2"/>
    <dbReference type="GeneID" id="3372260"/>
    <dbReference type="KEGG" id="cpv:cgd7_1340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1340"/>
    <dbReference type="InParanoid" id="Q5CYR2"/>
    <dbReference type="OMA" id="ADSTEAC"/>
    <dbReference type="OrthoDB" id="336758at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254561" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1055"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90189.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1084" mass="123731" checksum="3E482B00ED73104B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYV1</accession>
    <name>Q5CYV1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7 17">Phosphoglycerate kinase</fullName>
            <ecNumber evidence="6 17">2.7.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">cgd7_910</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 17">
            <text>(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:14801"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:57604"/>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.2.3"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3 17">Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5 18">Monomer.</text>
    </comment>
    <comment type="similarity">
        <text evidence="4 17">Belongs to the phosphoglycerate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.2.3" evidence="6 17"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628279.1">
        <property type="nucleotide sequence ID" value="XM_628277.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYV1"/>
    <dbReference type="FunCoup" id="Q5CYV1">
        <property type="interactions" value="60"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYV1"/>
    <dbReference type="GeneID" id="3371774"/>
    <dbReference type="KEGG" id="cpv:cgd7_910"/>
    <dbReference type="InParanoid" id="Q5CYV1"/>
    <dbReference type="OMA" id="DMIFDIG"/>
    <dbReference type="OrthoDB" id="275353at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00185"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043531">
        <property type="term" value="F:ADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004618">
        <property type="term" value="F:phosphoglycerate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006094">
        <property type="term" value="P:gluconeogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006096">
        <property type="term" value="P:glycolytic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd00318">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000003">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1260:FF:000019">
        <property type="entry name" value="Phosphoglycerate kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1260">
        <property type="entry name" value="Phosphoglycerate kinase, N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00145">
        <property type="entry name" value="Phosphoglyc_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001576">
        <property type="entry name" value="Phosphoglycerate_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015911">
        <property type="entry name" value="Phosphoglycerate_kinase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015824">
        <property type="entry name" value="Phosphoglycerate_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036043">
        <property type="entry name" value="Phosphoglycerate_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11406:SF0">
        <property type="entry name" value="PHOSPHOGLYCERATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00162">
        <property type="entry name" value="PGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF000724">
        <property type="entry name" value="Pgk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00477">
        <property type="entry name" value="PHGLYCKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53748">
        <property type="entry name" value="Phosphoglycerate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00111">
        <property type="entry name" value="PGLYCERATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12 16" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="14" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="11 17 19" id="KW-0418">Kinase</keyword>
    <keyword evidence="13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 17" id="KW-0808">Transferase</keyword>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="11"/>
            <end position="13"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="26"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <begin position="50"/>
            <end position="53"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="109"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="15">
        <location>
            <position position="157"/>
        </location>
        <ligand>
            <name>(2R)-3-phosphoglycerate</name>
            <dbReference type="ChEBI" id="CHEBI:58272"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <position position="330"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="16">
        <location>
            <begin position="359"/>
            <end position="362"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004838"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00008982"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00013061"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00016471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="PIRSR" id="PIRSR000724-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="RuleBase" id="RU000532"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="RuleBase" id="RU000696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAK90677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="404" mass="43313" checksum="5765A8D4F279598F" modified="2005-04-12" version="1" fragment="single">LKGKRVFIRVDMNVPVKNGQVTDKTRIIASLPTIKYALECGAKSVVLASHLGRPDGQRKMEYSLTVIVPILEELLGKSVIFAKDCVGNETEELCKNPAEGSIILLENLRFHLAEEGKGVNENGEKVKATPEEIEAFRKSLSSLGDIYVNDAFGTAHRAHSSMVGVDLTPKVAGLLLKKELEYFSKALESPTRPFLAIMGGAKVADKIQLIKNLLLKVDRMIIGGGMAFTFKKVMDNMQIGKSLFDEEGAKIVKEIMDTAKERNVQILLPSDFVIADNFSNEANARIIKDSEGIPDGWMGLDIGPESSNSFKELILSSKTIVANGPPGVFEMEKFSKGSRSMVEALVAATESGSITIVGGGDTASLVEKCGSANKVSHVSTGGGASLELLEGKLLPGVTSLSSKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYW6</accession>
    <name>Q5CYW6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90555.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628264.1">
        <property type="nucleotide sequence ID" value="XM_628262.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYW6"/>
    <dbReference type="GeneID" id="3372016"/>
    <dbReference type="KEGG" id="cpv:cgd7_750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_750"/>
    <dbReference type="InParanoid" id="Q5CYW6"/>
    <dbReference type="OMA" id="FICINTK"/>
    <dbReference type="OrthoDB" id="341148at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254413" evidence="2">
        <location>
            <begin position="23"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="331"/>
            <end position="352"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90555.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="380" mass="43535" checksum="50FD5FBAC5ED4E8D" modified="2005-04-12" version="1">MNLWVLRVIWLDVALLVGRVFGITGDESSVLFPYRNPKVGVIPISVGNGSGDLIVRIWEENVRLEWERSKEERRGECLIIGKGVSCGDFDCKKYMNDEQGVAKVCDYLEFTPENKWIPSFIDEDLPICRIFNLGSIAGIRNTLSEYLFNSPRACLCNGEKKSENFKILSPSVSGDDIGGWKFEIFKDNMEIPKIYPFNRFIVDVRVLVNPGWNLEFVLSSSSLQISKAAFSIVSLKKDYLCQGFPEDESLKILQPTKLSPKGSHIIQTYSWSPSKSNGYLKDGHFDYKFPVNHQTTTHYYLCYYHHYNSNSGHLLGNVYFRLNPEDATQTFSLILLIIIFTPLIFFSIHIIISSKFKTSIEKLQGYILFEDRNKVSSLFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPN1</accession>
    <name>A3FPN1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">aspartate--tRNA ligase</fullName>
            <ecNumber evidence="3">6.1.1.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_1540</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>tRNA(Asp) + L-aspartate + ATP = L-aspartyl-tRNA(Asp) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:19649"/>
            <dbReference type="Rhea" id="RHEA-COMP:9660"/>
            <dbReference type="Rhea" id="RHEA-COMP:9678"/>
            <dbReference type="ChEBI" id="CHEBI:29991"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78516"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.12" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51570.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388377.1">
        <property type="nucleotide sequence ID" value="XM_001388340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPN1"/>
    <dbReference type="FunCoup" id="A3FPN1">
        <property type="interactions" value="499"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPN1"/>
    <dbReference type="GeneID" id="3371783"/>
    <dbReference type="KEGG" id="cpv:cgd7_1540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1540"/>
    <dbReference type="InParanoid" id="A3FPN1"/>
    <dbReference type="OMA" id="WVHEIRD"/>
    <dbReference type="OrthoDB" id="372395at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017101">
        <property type="term" value="C:aminoacyl-tRNA synthetase multienzyme complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004815">
        <property type="term" value="F:aspartate-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006422">
        <property type="term" value="P:aspartyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04320">
        <property type="entry name" value="AspRS_cyto_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00776">
        <property type="entry name" value="AsxRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000013">
        <property type="entry name" value="Aspartate--tRNA ligase, cytoplasmic"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_02075">
        <property type="entry name" value="Asp_tRNA_synth_type2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004523">
        <property type="entry name" value="Asp-tRNA_synthase_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002312">
        <property type="entry name" value="Asp/Asn-tRNA-synth_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00458">
        <property type="entry name" value="aspS_nondisc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003483">
        <property type="entry name" value="PRK05159.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450:SF1">
        <property type="entry name" value="ASPARTATE--TRNA LIGASE, CYTOPLASMIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43450">
        <property type="entry name" value="ASPARTYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01042">
        <property type="entry name" value="TRNASYNTHASP"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 13" id="KW-0436">Ligase</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="12">
        <location>
            <begin position="223"/>
            <end position="524"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="8"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005312"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012841"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047904"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAZ51570.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="532" mass="60990" checksum="260AB203703A478C" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPV9</accession>
    <name>A3FPV9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">N(6)-L-threonylcarbamoyladenine synthase</fullName>
            <ecNumber evidence="1">2.3.1.234</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">N6-L-threonylcarbamoyladenine synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_3550</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8 9">
            <text>L-threonylcarbamoyladenylate + adenosine(37) in tRNA = N(6)-L-threonylcarbamoyladenosine(37) in tRNA + AMP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:37059"/>
            <dbReference type="Rhea" id="RHEA-COMP:10162"/>
            <dbReference type="Rhea" id="RHEA-COMP:10163"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74418"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="2.3.1.234"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="9">
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </cofactor>
        <text evidence="9">Binds 1 divalent metal cation per subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the KAE1 / TsaD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.234" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51532.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388338.1">
        <property type="nucleotide sequence ID" value="XM_001388301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPV9"/>
    <dbReference type="FunCoup" id="A3FPV9">
        <property type="interactions" value="158"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPV9"/>
    <dbReference type="GeneID" id="3375963"/>
    <dbReference type="KEGG" id="cpv:cgd6_3550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3550"/>
    <dbReference type="InParanoid" id="A3FPV9"/>
    <dbReference type="OMA" id="HHRSWVV"/>
    <dbReference type="OrthoDB" id="10254073at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000408">
        <property type="term" value="C:EKC/KEOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061711">
        <property type="term" value="F:tRNA N(6)-L-threonylcarbamoyladenine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002949">
        <property type="term" value="P:tRNA threonylcarbamoyladenosine modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd24132">
        <property type="entry name" value="ASKHA_NBD_OSGEP_like_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000105">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000141">
        <property type="entry name" value="Probable tRNA N6-adenosine threonylcarbamoyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01446">
        <property type="entry name" value="Kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000905">
        <property type="entry name" value="Gcp-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017861">
        <property type="entry name" value="KAE1/TsaD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034680">
        <property type="entry name" value="Kae1_archaea_euk"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR03722">
        <property type="entry name" value="arch_KAE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00329">
        <property type="entry name" value="gcp_kae1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11735:SF14">
        <property type="entry name" value="TRNA N6-ADENOSINE THREONYLCARBAMOYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00814">
        <property type="entry name" value="TsaD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00789">
        <property type="entry name" value="OSIALOPTASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 9" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Gcp-like" evidence="10">
        <location>
            <begin position="38"/>
            <end position="315"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="117"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="121"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="138"/>
            <end position="142"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="138"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="170"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="185"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="189"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="281"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="309"/>
        </location>
        <ligand>
            <name>a divalent metal cation</name>
            <dbReference type="ChEBI" id="CHEBI:60240"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030439"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00814"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51532.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="350" mass="38525" checksum="38ECE181017FA119" modified="2007-04-03" version="1">MEGSNNEVLISLGIESSANKVGVGIVTSKGEILANEKMTFVGPPGSGFLPRETAEFHRNNILHLVKQALEKSGINKNSITIISFTQGPGMGAPLAVGALVARMLSMLWSKPLIGVNHCVAHIEMGRLVTKVENPIVLYASGGNTQIIGYANKRYKILGETLDIAIGNCIDRFARVMKLDNYPAAGYHIEQMAKKGKNLISLPYVVKGMDLSFSGILTFGEELIAEKQKEFNNDEQKLQSFYQDFCFSLQETLFAMLIEVTERAISLLNSDSILLVGGVGCNLRLIEMMEQMAKDRGAIVCSMDDSYCIDNGAMIAHTGLLAYQKNFITKVEESAVSQRFRTDQVEILWRE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPZ2</accession>
    <name>A3FPZ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Serine/threonine protein kinase KKIALRE</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_3070</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388433.1">
        <property type="nucleotide sequence ID" value="XM_001388396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPZ2"/>
    <dbReference type="STRING" id="353152.A3FPZ2"/>
    <dbReference type="GeneID" id="3374652"/>
    <dbReference type="KEGG" id="cpv:cgd8_3070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3070"/>
    <dbReference type="InParanoid" id="A3FPZ2"/>
    <dbReference type="OMA" id="HANYVIP"/>
    <dbReference type="OrthoDB" id="548217at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000624">
        <property type="entry name" value="Mitogen-activated protein kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050117">
        <property type="entry name" value="MAPK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24055">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 8" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 8" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="7">
        <location>
            <begin position="13"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="42"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="511" mass="58133" checksum="60F95DC1B53DEE0C" modified="2007-04-03" version="1">MQGKCTLHGLNRYKTICEIGEGAFGVVFKCMDLVTNEIVALKEFKTIYSDENENSYVTKNSANGKVNTNFSHNKILREIATLRRLYGQKNIIQLKDFFLHENRYYLSLEYFPQTLLQYLEKSPKGLPIEIIRSSIYQLLTALKKCHSMGIIHRDVKPENILIKEIEKNMNLELKLCDFGFARFIQQNKSYSNQFKDSLSKSVDSLCVASRPLTSYVSTRWYRAPELLVKSTEYGPGIDVWAVGCIMAELIDGEPLFPGTSDIDQLYLIRNTIGKLDSKSQGILESDKRLYDAYKKHFYNGFISGSNSRYNTELSQSSAVIPPYQIISIKERYEKKVDLIALDFLQKSLTIDPKMRPDCQELLLHPFFSSINGTEGFAKYELECASSSLLNITDSSSKSLSLPIFFESCHSSAKHGGKNYDCEDNDGVNKFSENFDQSYAKNKCVLNDDKTTAPSTPDDKSTPLPHSGIFYNSKIWCEKISLPKFPHILPPPPKNINNLKNLSNIDTQENIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ18</accession>
    <name>A3FQ18_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388098.1">
        <property type="nucleotide sequence ID" value="XM_001388061.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ18"/>
    <dbReference type="STRING" id="353152.A3FQ18"/>
    <dbReference type="GeneID" id="3373942"/>
    <dbReference type="KEGG" id="cpv:cgd3_1020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1020"/>
    <dbReference type="InParanoid" id="A3FQ18"/>
    <dbReference type="OMA" id="CACAGRY"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd24138">
        <property type="entry name" value="TtcA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686:SF1">
        <property type="entry name" value="AMINOTRAN_5 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43686">
        <property type="entry name" value="SULFURTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1105" mass="127232" checksum="86F69CC3E93A51F1" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ34</accession>
    <name>A3FQ34_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Kinesin-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_2590</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. KIN-14 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388114.1">
        <property type="nucleotide sequence ID" value="XM_001388077.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ34"/>
    <dbReference type="SMR" id="A3FQ34"/>
    <dbReference type="STRING" id="353152.A3FQ34"/>
    <dbReference type="GeneID" id="3374073"/>
    <dbReference type="KEGG" id="cpv:cgd3_2590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2590"/>
    <dbReference type="InParanoid" id="A3FQ34"/>
    <dbReference type="OMA" id="CIGMSGV"/>
    <dbReference type="OrthoDB" id="3176171at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003777">
        <property type="term" value="F:microtubule motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007018">
        <property type="term" value="P:microtubule-based movement"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027640">
        <property type="entry name" value="Kinesin-like_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019821">
        <property type="entry name" value="Kinesin_motor_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001752">
        <property type="entry name" value="Kinesin_motor_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972">
        <property type="entry name" value="KINESIN-LIKE PROTEIN KLP-3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47972:SF45">
        <property type="entry name" value="PROTEIN CLARET SEGREGATIONAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00225">
        <property type="entry name" value="Kinesin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00380">
        <property type="entry name" value="KINESINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00129">
        <property type="entry name" value="KISc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00411">
        <property type="entry name" value="KINESIN_MOTOR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50067">
        <property type="entry name" value="KINESIN_MOTOR_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 7" id="KW-0493">Microtubule</keyword>
    <keyword evidence="5 6 7" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Kinesin motor" evidence="9">
        <location>
            <begin position="204"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="68"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="287"/>
            <end position="294"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU000394"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="543" mass="62093" checksum="8C1900BE94571DC3" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ37</accession>
    <name>A3FQ37_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Protein Roco7, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd3_2900</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51445.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388117.1">
        <property type="nucleotide sequence ID" value="XM_001388080.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ37"/>
    <dbReference type="STRING" id="353152.A3FQ37"/>
    <dbReference type="GeneID" id="3374070"/>
    <dbReference type="KEGG" id="cpv:cgd3_2900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2900"/>
    <dbReference type="InParanoid" id="A3FQ37"/>
    <dbReference type="OMA" id="LMAACTH"/>
    <dbReference type="OrthoDB" id="1714095at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd13999">
        <property type="entry name" value="STKc_MAP3K-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001245">
        <property type="entry name" value="Ser-Thr/Tyr_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051681">
        <property type="entry name" value="Ser/Thr_Kinases-Pseudokinases"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329:SF288">
        <property type="entry name" value="MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44329">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE TNNI3K-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07714">
        <property type="entry name" value="PK_Tyr_Ser-Thr"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="314"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="341"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51445.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="632" mass="71870" checksum="A90FD14E4B52EE28" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQB2</accession>
    <name>A3FQB2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">ADP-ribosylation factor-like protein 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_200</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the small GTPase superfamily. Arf family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51311.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388134.1">
        <property type="nucleotide sequence ID" value="XM_001388097.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQB2"/>
    <dbReference type="FunCoup" id="A3FQB2">
        <property type="interactions" value="228"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQB2"/>
    <dbReference type="GeneID" id="3371474"/>
    <dbReference type="KEGG" id="cpv:cgd1_200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_200"/>
    <dbReference type="InParanoid" id="A3FQB2"/>
    <dbReference type="OMA" id="KTHHWQI"/>
    <dbReference type="OrthoDB" id="2011769at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd04154">
        <property type="entry name" value="Arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000393">
        <property type="entry name" value="ADP-ribosylation factor-like 2, arl2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045873">
        <property type="entry name" value="Arl2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044612">
        <property type="entry name" value="ARL2/3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006689">
        <property type="entry name" value="Small_GTPase_ARF/SAR"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45697">
        <property type="entry name" value="ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00025">
        <property type="entry name" value="Arf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00328">
        <property type="entry name" value="SAR1GTPBP"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00178">
        <property type="entry name" value="SAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51417">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="2" id="KW-0519">Myristate</keyword>
    <keyword evidence="3 7 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="23"/>
            <end position="30"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="30"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="8">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <position position="69"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="7">
        <location>
            <begin position="125"/>
            <end position="128"/>
        </location>
        <ligand>
            <name>GTP</name>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="183"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00026198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRSR" id="PIRSR606689-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51311.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="183" mass="20710" checksum="BF292A645BECA92D" modified="2007-04-03" version="1" fragment="single">MTLLQVIRKTKMKEKEMRILVLGLDNAGKTTVVRKFAGEDISTIQPTLGFNIKTLLHGKYRLNTWDIGGQKTIRSYWRNYFESTDGIIWVVDSTNIERMDSCSEELHCLLSEERLSGASLLVFANKQDLSNALKPEEVAHALGLSNINNRHWRIQSCCGLDGKGLNEGIDWIVNDIATKVFLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQC0</accession>
    <name>A3FQC0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Oxoglutarate/malate translocator protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd1_600</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388142.1">
        <property type="nucleotide sequence ID" value="XM_001388105.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQC0"/>
    <dbReference type="FunCoup" id="A3FQC0">
        <property type="interactions" value="265"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQC0"/>
    <dbReference type="GeneID" id="3371499"/>
    <dbReference type="KEGG" id="cpv:cgd1_600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_600"/>
    <dbReference type="InParanoid" id="A3FQC0"/>
    <dbReference type="OMA" id="TLWRGAI"/>
    <dbReference type="OrthoDB" id="756301at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="1.50.40.10:FF:000009">
        <property type="entry name" value="Mitochondrial 2-oxoglutarate/malate carrier protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050391">
        <property type="entry name" value="Mito_Metabolite_Transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45618">
        <property type="entry name" value="MITOCHONDRIAL DICARBOXYLATE CARRIER-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00153">
        <property type="entry name" value="Mito_carr"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 10 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3 11" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="1"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="73"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="repeat" description="Solcar" evidence="10">
        <location>
            <begin position="174"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU000488"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="274" mass="31065" checksum="2A96336262B04C58" modified="2007-04-03" version="1">MQLQNFEGYSKPTPFSLARDIVNKNGILGLYKGLDAGLIRQLTYSTARLGIFRLLCDYYKNQMVYQGHKVCNLSLGVKALIGLTSGGISSFICNPVDLALIRLQTNSLLPLSKQKYYKNVLQAMKYIIKEEGFFSMWKGSIPSIIRAMSINMGMLATFDHFIEVCYRWTGPEKNQVFVKVLSSILSGAVASVVSLPFDTIKTQIQKQTVDEEDSESLITKHEDHNLNSYSKVITHIYKSQGLSGFFKGYLTYYFRIAPHAMITLLCMDWLNKKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQC2</accession>
    <name>A3FQC2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_680</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51321.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388144.1">
        <property type="nucleotide sequence ID" value="XM_001388107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQC2"/>
    <dbReference type="GeneID" id="3371498"/>
    <dbReference type="KEGG" id="cpv:cgd1_680"/>
    <dbReference type="InParanoid" id="A3FQC2"/>
    <dbReference type="OMA" id="KEXEGEE"/>
    <dbReference type="OrthoDB" id="344369at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="69"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="255"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="262"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="290"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51321.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="360" mass="42435" checksum="EB60373A87F44BF4" modified="2007-04-03" version="1">MSELRREELIISDIPALLKEEMIEDDKSLSLELILDSEKRKNEISDNWSFGSNEEFNLLSIFKDDNANIKNNEQLDGQKDWEKDPKKDQKKSDEKQKDKKEAEKEVEKNAEKNAKKNTEKNQKKESENKVQEKGNKKREKEEADKAKTKEDVKKEVKKKDQKEGQKKETKINDQEKDPKKDQKKDPKKETKIKDQEKDPKKDQKKDLKKETKKDHKEDPKKDQKKDLKNKSDQAKTKDEKDTKKDSGKEVQKKDSSSQNKAKYKETMKEDNITDSESDHKEKKNAKIKKNSSSSSKSINIKIPYRETSHIPSCLFEQDNTNNLDFNRIKNYNEYIHETSRLFSVDSACRYVFIKRISKLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQF3</accession>
    <name>A3FQF3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_2860</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388175.1">
        <property type="nucleotide sequence ID" value="XM_001388138.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQF3"/>
    <dbReference type="SMR" id="A3FQF3"/>
    <dbReference type="FunCoup" id="A3FQF3">
        <property type="interactions" value="151"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQF3"/>
    <dbReference type="GeneID" id="3371394"/>
    <dbReference type="KEGG" id="cpv:cgd1_2860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2860"/>
    <dbReference type="InParanoid" id="A3FQF3"/>
    <dbReference type="OMA" id="MPIMARI"/>
    <dbReference type="OrthoDB" id="6329284at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008425">
        <property type="term" value="F:2-methoxy-6-polyprenyl-1,4-benzoquinol methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02440">
        <property type="entry name" value="AdoMet_MTases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004033">
        <property type="entry name" value="UbiE/COQ5_MeTrFase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023576">
        <property type="entry name" value="UbiE/COQ5_MeTrFase_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01934">
        <property type="entry name" value="MenG_MenH_UbiE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591:SF24">
        <property type="entry name" value="2-METHOXY-6-POLYPRENYL-1,4-BENZOQUINOL METHYLASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43591">
        <property type="entry name" value="METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01209">
        <property type="entry name" value="Ubie_methyltran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51608">
        <property type="entry name" value="SAM_MT_UBIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01183">
        <property type="entry name" value="UBIE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01184">
        <property type="entry name" value="UBIE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="285" mass="32390" checksum="907066AE82582DD2" modified="2007-04-03" version="1">MNNLRNISKSGIGYSFCRSLVRKTHNLFGFKFLNIGIKNQINLARAARFNSTIKDSNTGENNKYVYFGDRIVDKDTKRKLIEQVFSSVSNKYDLMNDLMSLGLHRCWKDIFVENIISPESFLRIKREKDEDFSNVTILDVAGGTGDVSFRIIDKFRKDNIEVLPNIIVVDSNNEMIEQGQLKSIEKGDCSIIWIKDDGEQLSQIPSNSVDVVAISFGIRNFTNIEKGLKSFYRVLKPGGRFLCLEFSKVNNPLISSIYQLYSSIAIPSLGEFVAGDRESYNYLVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPQ0</accession>
    <name>Q5CPQ0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide containing cysteine rich protein, gene anchored to telomere</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_4500</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625464.1">
        <property type="nucleotide sequence ID" value="XM_625464.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPQ0"/>
    <dbReference type="STRING" id="353152.Q5CPQ0"/>
    <dbReference type="GeneID" id="3372436"/>
    <dbReference type="KEGG" id="cpv:cgd4_4500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4500"/>
    <dbReference type="InParanoid" id="Q5CPQ0"/>
    <dbReference type="OMA" id="HNRLKAG"/>
    <dbReference type="OrthoDB" id="344294at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254241" evidence="2">
        <location>
            <begin position="19"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="70"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="135"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="269"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="391"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="76"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="135"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="395"/>
            <end position="410"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="418"/>
            <end position="435"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="592"/>
            <end position="601"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="609"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="653"/>
            <end position="668"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="689" mass="76231" checksum="A7198FC082379EA3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPQ6</accession>
    <name>Q5CPQ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">OTU like cysteine protease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_4430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625458.1">
        <property type="nucleotide sequence ID" value="XM_625458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPQ6"/>
    <dbReference type="STRING" id="353152.Q5CPQ6"/>
    <dbReference type="GeneID" id="3372432"/>
    <dbReference type="KEGG" id="cpv:cgd4_4430"/>
    <dbReference type="InParanoid" id="Q5CPQ6"/>
    <dbReference type="OMA" id="FANGPHY"/>
    <dbReference type="OrthoDB" id="415023at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004843">
        <property type="term" value="F:cysteine-type deubiquitinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016579">
        <property type="term" value="P:protein deubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd22748">
        <property type="entry name" value="OTU_OTUD6-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003323">
        <property type="entry name" value="OTU_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050704">
        <property type="entry name" value="Peptidase_C85-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419:SF10">
        <property type="entry name" value="DEUBIQUITINASE OTUD6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12419">
        <property type="entry name" value="OTU DOMAIN CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02338">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50802">
        <property type="entry name" value="OTU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0645">Protease</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="OTU" evidence="1">
        <location>
            <begin position="20"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="141" mass="16531" checksum="402EA9F65BAA5EAD" modified="2005-04-12" version="1" fragment="single">FNIHYFSSIKHQLEIKKKGLYSIKELRCIAVDYIESNRKTMEPFVLASVENTDITFEEYCDNIRNTNEWGGEVELVALSNSLEVPITVIRALNHRNESYGEQFYEEYEDDEENSVKENTLYIVYHIHLFANGPHYNSTISI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPQ9</accession>
    <name>Q5CPQ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_4400</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625455.1">
        <property type="nucleotide sequence ID" value="XM_625455.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPQ9"/>
    <dbReference type="GeneID" id="3372443"/>
    <dbReference type="KEGG" id="cpv:cgd4_4400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4400"/>
    <dbReference type="InParanoid" id="Q5CPQ9"/>
    <dbReference type="OMA" id="KIWYKIS"/>
    <dbReference type="OrthoDB" id="343528at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.490">
        <property type="entry name" value="Single helix bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="85"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="286" mass="32895" checksum="CD390E7425AFD5D5" modified="2005-04-12" version="1">MNNPVKETNDWYSLQERALKLSDQAFRSLVGEYEEQIRNLKYEITSRDKKIQDLKSKLDITNKQLNALKTEKNELCNILDALETQNRSRDSKLEEFYLEISEIKGEQELSLAKLERCLAKYGDVSCSNHEYGKKRNDELNHDKDDNRSLLSEQCENVEIKEIPHLLVTEAIHHPSNFITINNSELCFENCTEDIGGLISSHQKTGSGNSPRSDIVQSSVSKSGVWNRISQVLPRDSYFSLLNFVRQYHLGLMNEEELQTEIQNALLSNNEAVRNAFTKDILHLSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPT5</accession>
    <name>Q5CPT5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Hypothetical conserved protein, possible transmembrane domain near C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_4110</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the RMD1/sif2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625429.1">
        <property type="nucleotide sequence ID" value="XM_625429.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPT5"/>
    <dbReference type="FunCoup" id="Q5CPT5">
        <property type="interactions" value="21"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPT5"/>
    <dbReference type="GeneID" id="3372417"/>
    <dbReference type="KEGG" id="cpv:cgd4_4110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4110"/>
    <dbReference type="InParanoid" id="Q5CPT5"/>
    <dbReference type="OMA" id="IDIVWTI"/>
    <dbReference type="OrthoDB" id="18302at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003734">
        <property type="entry name" value="DUF155"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051624">
        <property type="entry name" value="RMD1/Sad1-interacting"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16255:SF1">
        <property type="entry name" value="REQUIRED FOR MEIOTIC NUCLEAR DIVISION PROTEIN 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02582">
        <property type="entry name" value="DUF155"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="294"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="DUF155" evidence="3">
        <location>
            <begin position="97"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02582"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="321" mass="37715" checksum="91D6B8F12A7AE981" modified="2005-04-12" version="1">MEDIDFHSDGNLKSRQFKSSIRVARKRADIQTSLKELEQEIKEPAGMVWACCFANEMDFPMILEAWKQGDLSSKQIHIEMTFSEVVCLRWLQNRICYVFKFGCVVGWDLTRAERVAIVNILKTFIKQPLHIRTDESQDDDMTYVWGERPSIKQDNIHLVSDSLLERLSYSYALSQSVKLSVFESVVDQNIDSTRSLPESLAKSGTIKDNREDISKRIGELFINRFYINLQTDILDTPDIFWDLQDYEPHYITCRNYLDIPKRVEILNQRLDIIKDLYDMLNNELSLQHGYKLEWIVIYLICAEIVIEVVWNILIRDIFNLV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPW1</accession>
    <name>Q5CPW1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Alpha/beta hydrolase superfamily protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87514.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625518.1">
        <property type="nucleotide sequence ID" value="XM_625518.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPW1"/>
    <dbReference type="STRING" id="353152.Q5CPW1"/>
    <dbReference type="ESTHER" id="crypv-q5cpw1">
        <property type="family name" value="6_AlphaBeta_hydrolase"/>
    </dbReference>
    <dbReference type="GeneID" id="3372476"/>
    <dbReference type="KEGG" id="cpv:cgd8_590"/>
    <dbReference type="InParanoid" id="Q5CPW1"/>
    <dbReference type="OMA" id="FHSTLCN"/>
    <dbReference type="OrthoDB" id="408373at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050266">
        <property type="entry name" value="AB_hydrolase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798:SF33">
        <property type="entry name" value="HYDROLASE, PUTATIVE (AFU_ORTHOLOGUE AFUA_2G14860)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43798">
        <property type="entry name" value="MONOACYLGLYCEROL LIPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00111">
        <property type="entry name" value="ABHYDROLASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="domain" description="AB hydrolase-1" evidence="2">
        <location>
            <begin position="43"/>
            <end position="293"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87514.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="331" mass="37794" checksum="2659B38C72ED0466" modified="2005-04-12" version="1" fragment="single">NVCKKEMESKYKFEEGKFTEGPNGRINYALSFPNIEKAAYKGPLVICFHGLLSSISSFKQLETECLKSGLAVLRIDMPGHGLSSWNYFGKLTTDDFIKQVDTVLINLGLEKLLLYLVGISMGGLMTLCYAGAHPEKVLKVASLCPACFCRPLSGIQSFVLKNFPGVFRFFENSLPLYLLKSRDNILEDYYDPEKINQEIVNLRYLRHRYYGRQLRSTFGRVVTGFDFWENEQALKVFMDKYISLRGITGVCFFLGLYDDMVPADLLIPKLKKMMPKTRAIIYQNCKHQLLEEGHNIVGDIVKYFNSNSESEYSKIGLAVESIIIQDEIQQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPY0</accession>
    <name>Q5CPY0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative oxidase or dehydrogenase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_380</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87486.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625499.1">
        <property type="nucleotide sequence ID" value="XM_625499.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPY0"/>
    <dbReference type="SMR" id="Q5CPY0"/>
    <dbReference type="FunCoup" id="Q5CPY0">
        <property type="interactions" value="30"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPY0"/>
    <dbReference type="GeneID" id="3372448"/>
    <dbReference type="KEGG" id="cpv:cgd8_380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_380"/>
    <dbReference type="InParanoid" id="Q5CPY0"/>
    <dbReference type="OMA" id="NFLFEVP"/>
    <dbReference type="OrthoDB" id="498204at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.9.10">
        <property type="entry name" value="D-Amino Acid Oxidase, subunit A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.50.60">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006076">
        <property type="entry name" value="FAD-dep_OxRdtase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036188">
        <property type="entry name" value="FAD/NAD-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01266">
        <property type="entry name" value="DAO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51905">
        <property type="entry name" value="FAD/NAD(P)-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FAD dependent oxidoreductase" evidence="1">
        <location>
            <begin position="65"/>
            <end position="249"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87486.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="526" mass="59471" checksum="008783C1B02FD14B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ15</accession>
    <name>Q5CQ15_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Possible vacuolar protein sorting associated protein (VPS)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_4500</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the VPS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87593.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625611.1">
        <property type="nucleotide sequence ID" value="XM_625611.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ15"/>
    <dbReference type="GeneID" id="3372553"/>
    <dbReference type="KEGG" id="cpv:cgd5_4500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4500"/>
    <dbReference type="InParanoid" id="Q5CQ15"/>
    <dbReference type="OrthoDB" id="272810at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045053">
        <property type="term" value="P:protein retention in Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006623">
        <property type="term" value="P:protein targeting to vacuole"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026847">
        <property type="entry name" value="VPS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026854">
        <property type="entry name" value="VPS13_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166:SF93">
        <property type="entry name" value="INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16166">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12624">
        <property type="entry name" value="VPS13_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Chorein N-terminal" evidence="4">
        <location>
            <begin position="1"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="127"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="296"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="131"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="147"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="3">
        <location>
            <begin position="304"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="319"/>
            <end position="328"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006545"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF12624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87593.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="399" mass="45203" checksum="E7B92EF30E20E693" modified="2005-04-12" version="1">MLETILQRLLGRYLEPYVYNLSRENLRLGVLSGNLVLENLKLKENLGDILHLPLSIVSGQIGHVSITIPWTSLGYKPLVIKLKELHVVVRPKDYGNVDEDTLRKELREAKEKLIEFKEKRLNERFLNGELSNSSNNPNEVPESVGHLSKDERKDLNGVKDSKSIGGSDDANNSANGTNLLWRIIKKIVANVQLEIQDIHICMVGFQSSDDKLVVNHSRNTRSDIIMGAMIKSGFVVTTDSLGNRDTSSLNSESQKLDDPNALYKTIEINEVGIYIGQYFPNTFNFNSIDEGRLKDFNSESSIGNHHRNHNHRNSHPHNHQSPSNSPNRIKNDKASYEMVNIVNVRNKLLETSDEKSMNDKKTVQALESKYLLIYDENDPHKSLGAWRLEXXXXXXXXXA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ98</accession>
    <name>Q5CQ98_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625528.1">
        <property type="nucleotide sequence ID" value="XM_625528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ98"/>
    <dbReference type="GeneID" id="3372537"/>
    <dbReference type="KEGG" id="cpv:cgd5_3610"/>
    <dbReference type="InParanoid" id="Q5CQ98"/>
    <dbReference type="OrthoDB" id="338345at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="28"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="442" mass="51405" checksum="2234580D7C723AB6" modified="2005-04-12" version="1">MGNTNEKVNISEKDMVNNDSGGAKLKKEKGEITKEMKNKANKSDEKEKIKVSKGKGELEKEGNNDEKKSKKQIEKIDIMNDNNTPEKHEKRDSVVKFEIPLKDKLSLKRRCRLNIPPCSRVPEPDYEIKLLINDKYDGPFKLEMKNNPCEIHITGFEGILLKRIKKRDIMFVQTIKNECIRMFIKGSEDQESDNLTNSEQLDSTNMYTSQYLGEVMQIICKFVNKQDCESFEFFFPFIYGLIVHSDKVKIPVSDFVDFGEYVIGTSKHILKRLDEYKNFNDNICEDNMSIDEENEDDLLDSYEKKMIAQEREFFSRSNLELIYRAESPFGLEIPNSSDDNIEDKEEEERILREKQEKYSKFFPVTIIGEAESGGIITFKDISSIGLKYVPEVIEWRISKNIGGNKAEYEEIPISVSKSFQINIDHVSLILKNSFSFKFYEFI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQC4</accession>
    <name>Q5CQC4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Transcription factor TFIIIB, SANT domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_1270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87620.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625724.1">
        <property type="nucleotide sequence ID" value="XM_625724.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQC4"/>
    <dbReference type="STRING" id="353152.Q5CQC4"/>
    <dbReference type="GeneID" id="3372647"/>
    <dbReference type="KEGG" id="cpv:cgd4_1270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1270"/>
    <dbReference type="InParanoid" id="Q5CQC4"/>
    <dbReference type="OMA" id="IMEGRVY"/>
    <dbReference type="OrthoDB" id="272624at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000126">
        <property type="term" value="C:transcription factor TFIIIB complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001156">
        <property type="term" value="F:TFIIIC-class transcription factor complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070898">
        <property type="term" value="P:RNA polymerase III preinitiation complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039467">
        <property type="entry name" value="TFIIIB_B''_Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929">
        <property type="entry name" value="RNA POLYMERASE III TRANSCRIPTION INITIATION FACTOR B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22929:SF0">
        <property type="entry name" value="TRANSCRIPTION FACTOR TFIIIB COMPONENT B'' HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15963">
        <property type="entry name" value="Myb_DNA-bind_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Transcription factor TFIIIB component B'' Myb" evidence="2">
        <location>
            <begin position="198"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="25"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="31"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="45"/>
            <end position="57"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF15963"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87620.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="278" mass="31558" checksum="76FA109ACE4E894D" modified="2005-04-12" version="1">MAGNDSTRGDNATLWSIVIKTAYRKRRSKRKQNEQNSEKDGLNLDGSNNSTSITENDSFGDRYSNDNTFFSSNQSGLGISDTKNNGSDLLNYLLDGNSGQENKKLEDKNKTSNLFEGINGENNSNNSFLSELFSMDKLNGDSNSKLSIDCKGDIILEENLLNNSSGKQMDWLGLMEGRVYINENMAGTSLQPYSGAYKRTKGKRWSTEQTNKFYDALSLFGTDLMLVKSVFPEFTDKQIHDKFKAEEKKNKERMDDILINNKKKLTKEDVLRFKQKYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQJ4</accession>
    <name>Q5CQJ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">60S ribosomal protein L18</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd4_470</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87728.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625654.1">
        <property type="nucleotide sequence ID" value="XM_625654.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQJ4"/>
    <dbReference type="FunCoup" id="Q5CQJ4">
        <property type="interactions" value="456"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQJ4"/>
    <dbReference type="GeneID" id="3372659"/>
    <dbReference type="KEGG" id="cpv:cgd4_470"/>
    <dbReference type="InParanoid" id="Q5CQJ4"/>
    <dbReference type="OMA" id="IDICHKN"/>
    <dbReference type="OrthoDB" id="6353017at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.100.10.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.100.10.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000039">
        <property type="entry name" value="Ribosomal_eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021131">
        <property type="entry name" value="Ribosomal_uL15/eL18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036227">
        <property type="entry name" value="Ribosomal_uL15/eL18_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10934:SF2">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17135">
        <property type="entry name" value="Ribosomal_L18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52080">
        <property type="entry name" value="Ribosomal proteins L15p and L18e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Large ribosomal subunit protein uL15/eL18" evidence="5">
        <location>
            <begin position="5"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="156"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="4">
        <location>
            <begin position="180"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006815"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF17135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87728.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="190" mass="21441" checksum="A08FEC86023D30F0" modified="2005-04-12" version="1" fragment="single">ELNMGIDLKAGGRVKKTQSKRTRSTNPYRILLSKLYTFLGRRTDSSFNDTVLHRLKMARRFQAPISVSRLVQFMNGKEGKIAAVVGTVTDDTRVLKIPKLTVCALRFTETARKHIEKYGGECLTFDQLALRAPKGSNVVLLRGKTKARIQEKYFGRAPGLPKSTSRPRVQSKGRKFEKARGRRASRAYKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQJ6</accession>
    <name>Q5CQJ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Very large low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87677.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625652.1">
        <property type="nucleotide sequence ID" value="XM_625652.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CQJ6">
        <property type="interactions" value="9"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQJ6"/>
    <dbReference type="GeneID" id="3372730"/>
    <dbReference type="KEGG" id="cpv:cgd4_450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_450"/>
    <dbReference type="InParanoid" id="Q5CQJ6"/>
    <dbReference type="OMA" id="DEWEYKY"/>
    <dbReference type="OrthoDB" id="17907at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016504">
        <property type="term" value="F:peptidase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070628">
        <property type="term" value="F:proteasome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010499">
        <property type="term" value="P:proteasomal ubiquitin-independent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032430">
        <property type="entry name" value="Blm10_mid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035309">
        <property type="entry name" value="PSME4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021843">
        <property type="entry name" value="PSME4_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR32170:SF3">
        <property type="entry name" value="PROTEASOME ACTIVATOR COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16507">
        <property type="entry name" value="HEAT_PSME4_mid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11919">
        <property type="entry name" value="PSME4_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Proteasome activator Blm10 middle HEAT repeats region" evidence="6">
        <location>
            <begin position="417"/>
            <end position="995"/>
        </location>
    </feature>
    <feature type="domain" description="Proteasome activator complex subunit 4 C-terminal" evidence="5">
        <location>
            <begin position="2336"/>
            <end position="2422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="2068"/>
            <end position="2095"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF11919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF16507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87677.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2423" mass="285878" checksum="A43C3704FB692BAE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQP4</accession>
    <name>Q5CQP4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ank repeat protein with possible signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd4_3830</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625958.1">
        <property type="nucleotide sequence ID" value="XM_625958.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQP4"/>
    <dbReference type="GeneID" id="3372919"/>
    <dbReference type="KEGG" id="cpv:cgd4_3830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3830"/>
    <dbReference type="InParanoid" id="Q5CQP4"/>
    <dbReference type="OMA" id="SEGHICN"/>
    <dbReference type="OrthoDB" id="194358at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173">
        <property type="entry name" value="ANKYRIN REPEAT CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24173:SF74">
        <property type="entry name" value="ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="12"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="893"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1050"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1143"/>
            <end position="1164"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1170"/>
            <end position="1193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1493"/>
            <end position="1515"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1536"/>
            <end position="1559"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1565"/>
            <end position="1585"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1631"/>
            <end position="1650"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="1662"/>
            <end position="1686"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="155"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="3">
        <location>
            <begin position="189"/>
            <end position="221"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1736" mass="200429" checksum="9F5EAADD0CAD2B30" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQP6</accession>
    <name>Q5CQP6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative transcription factor IIE alpha subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_3810</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the TFIIE alpha subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87749.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625956.1">
        <property type="nucleotide sequence ID" value="XM_625956.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQP6"/>
    <dbReference type="STRING" id="353152.Q5CQP6"/>
    <dbReference type="GeneID" id="3372796"/>
    <dbReference type="KEGG" id="cpv:cgd4_3810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3810"/>
    <dbReference type="InParanoid" id="Q5CQP6"/>
    <dbReference type="OMA" id="FMELQDE"/>
    <dbReference type="OrthoDB" id="361102at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005673">
        <property type="term" value="C:transcription factor TFIIE complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006367">
        <property type="term" value="P:transcription initiation at RNA polymerase II promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039997">
        <property type="entry name" value="TFE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017919">
        <property type="entry name" value="TFIIE/TFIIEa_HTH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002853">
        <property type="entry name" value="TFIIE_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097:SF7">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR IIE SUBUNIT 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13097">
        <property type="entry name" value="TRANSCRIPTION INITIATION FACTOR IIE, ALPHA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00531">
        <property type="entry name" value="TFIIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57783">
        <property type="entry name" value="Zinc beta-ribbon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51344">
        <property type="entry name" value="HTH_TFE_IIE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HTH TFE/IIEalpha-type" evidence="3">
        <location>
            <begin position="25"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="86"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="301"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="431"/>
            <end position="454"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="91"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="301"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="311"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="439"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51344"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87749.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="504" mass="56022" checksum="2FC403CEF4CF066D" modified="2005-04-12" version="1">MNKQDSHPSRNNYDTQKFPYNPENFKTFVQILLRLFHDSPAIIVGDCLIREQKSFTDRDLATKLNLSDRQVREALRQLEEDLIVVKDQKSNDGSQSNSSSSDQFSNKNNGTLNFSTDLESKYSSNQGGSGSNSAYFINNSTGLPSNRIGPSSFRINPYLPAVVEWQYNTIIREIDQEIKDAVNLDELMCNRCNAKYSSLEALSLDLNPDDGLFLCRFCNEKLKSVDSASFRNAAKDKAERVRSQLQILSNSLELVKNMHIPVFPPYQSKNDINFNKTKLPNSLENDGNIDSKISDDQITKTSLSNETSTPISIDNNSSPISNQSNFNININHPSSGIRNSNSTSSISSSSSPQVLPQNTISKVKFGIKLSAKSTSSIIGTSNSHYSKLSGNNNAIKQENSSIISSSNLSNNFTNSSNIKITSIITDNIKSIDQESNRHTPTTASSSSKSPAKIEEPTFSVSAIKDKVFKITEIDDDIINQMTDTEYLKYDELLQQYQTLGLINT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="130" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQZ5</accession>
    <name>Q5CQZ5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="15">P-type sodium-transporting ATPase4</fullName>
            <ecNumber evidence="12">7.2.2.3</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">cgd4_2720</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>Na(+)(in) + ATP + H2O = Na(+)(out) + ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:14633"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29101"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="7.2.2.3"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="14">
            <dbReference type="Rhea" id="RHEA:14634"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="13">Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.2.2.3" evidence="12"/>
    <dbReference type="EMBL" id="AAEE01000008">
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        <property type="entry name" value="CATION TRANSPORTING ATPASE"/>
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    <dbReference type="PANTHER" id="PTHR43294">
        <property type="entry name" value="SODIUM/POTASSIUM-TRANSPORTING ATPASE SUBUNIT ALPHA"/>
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        <property type="match status" value="1"/>
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        <property type="entry name" value="Cation_ATPase_N"/>
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        <property type="entry name" value="E1-E2_ATPase"/>
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        <property type="entry name" value="Hydrolase"/>
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    <dbReference type="PRINTS" id="PR00119">
        <property type="entry name" value="CATATPASE"/>
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    <dbReference type="SFLD" id="SFLDG00002">
        <property type="entry name" value="C1.7:_P-type_atpase_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="p-type_atpase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00831">
        <property type="entry name" value="Cation_ATPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81653">
        <property type="entry name" value="Calcium ATPase, transduction domain A"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF81665">
        <property type="entry name" value="Calcium ATPase, transmembrane domain M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
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    <dbReference type="SUPFAM" id="SSF81660">
        <property type="entry name" value="Metal cation-transporting ATPase, ATP-binding domain N"/>
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    </dbReference>
    <dbReference type="PROSITE" id="PS00154">
        <property type="entry name" value="ATPASE_E1_E2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="9" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10 17" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0915">Sodium</keyword>
    <keyword evidence="11" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="6" id="KW-1278">Translocase</keyword>
    <keyword evidence="3 17" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 17" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="11" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="260"/>
            <end position="286"/>
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    </feature>
    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
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    <feature type="transmembrane region" description="Helical" evidence="17">
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    <feature type="transmembrane region" description="Helical" evidence="17">
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    <feature type="transmembrane region" description="Helical" evidence="17">
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    <feature type="transmembrane region" description="Helical" evidence="17">
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            <begin position="1258"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
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            <begin position="1440"/>
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    <feature type="transmembrane region" description="Helical" evidence="17">
        <location>
            <begin position="1470"/>
            <end position="1488"/>
        </location>
    </feature>
    <feature type="domain" description="Cation-transporting P-type ATPase N-terminal" evidence="18">
        <location>
            <begin position="213"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
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        </location>
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    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="764"/>
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    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="866"/>
            <end position="885"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="16">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
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    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
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    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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    <evidence type="ECO:0000256" key="6">
        <source>
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        <source>
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        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
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    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00035029"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="ARBA" id="ARBA00038148"/>
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    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00049499"/>
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    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00067200"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="18">
        <source>
            <dbReference type="SMART" id="SM00831"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAK87832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1528" mass="168831" checksum="3665BE1FCE5896B3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR49</accession>
    <name>Q5CR49_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">phosphatidylinositol N-acetylglucosaminyltransferase</fullName>
            <ecNumber evidence="2">2.4.1.198</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="6">GlcNAc-PI synthesis protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_2100</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.198" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87941.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625803.1">
        <property type="nucleotide sequence ID" value="XM_625803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR49"/>
    <dbReference type="FunCoup" id="Q5CR49">
        <property type="interactions" value="139"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR49"/>
    <dbReference type="GeneID" id="3372985"/>
    <dbReference type="KEGG" id="cpv:cgd4_2100"/>
    <dbReference type="InParanoid" id="Q5CR49"/>
    <dbReference type="OMA" id="SHFWMSG"/>
    <dbReference type="OrthoDB" id="734129at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000506">
        <property type="term" value="C:glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017176">
        <property type="term" value="F:phosphatidylinositol N-acetylglucosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd03796">
        <property type="entry name" value="GT4_PIG-A-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.2000:FF:000026">
        <property type="entry name" value="Phosphatidylinositol N-acetylglucosaminyltransferase subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039507">
        <property type="entry name" value="PIG-A/GPI3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013234">
        <property type="entry name" value="PIGA_GPI_anchor_biosynthesis"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871">
        <property type="entry name" value="N-ACETYLGLUCOSAMINYL-PHOSPHATIDYLINOSITOL BIOSYNTHETIC PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45871:SF1">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08288">
        <property type="entry name" value="PIGA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="7" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="413"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="PIGA GPI anchor biosynthesis" evidence="9">
        <location>
            <begin position="61"/>
            <end position="149"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="8">
        <location>
            <begin position="215"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012420"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00032160"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF08288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87941.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="451" mass="51399" checksum="EA6A4358C30D71E9" modified="2005-04-12" version="1" fragment="single">INILIKRMKSDKPSYSEKNGLPNICMVSDFFYPGLGGVEMHIYELSQCLMVRGYKVIVVTHSRNDRYGVRYMGIGLKVYYLPYKSIYDNVVYPSLFTLFPLFRQILIREKIDIVHGHQSVSMLALECLFHATTMGYRVVFTDHSLFGLSNYDSIHANNFFRINLSCIDNVICVSHTNKKNLIYRSLISPKNVTVIPNAIDSNDFLPNPNYKSPINNEVIVISICRMTYRKGVDLLVEIIPRICNSDPNVRFILGGDGPKKHLLHEMCKKYNLSNRVELLGSVPHTQVCRVLQRGHIFLNTSLTEAFGISIIEAASCGLLVVSSNVGGIPEILPQEFLRLSNPSISNMVNELKIAVNIIREGKFDPYSSHKKISAMYSWHDIAKRTVSVYQKSNQVDIIGTKERILRIYKTGNLIGKIFALIAALDYFIWFFLEFFYPKESIEHCIDFPGIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR62</accession>
    <name>Q5CR62_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Ubiquitin-like modifier-activating enzyme 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_1960</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ubiquitin-activating E1 family. UBA5 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87945.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625790.1">
        <property type="nucleotide sequence ID" value="XM_625790.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR62"/>
    <dbReference type="STRING" id="353152.Q5CR62"/>
    <dbReference type="GeneID" id="3372761"/>
    <dbReference type="KEGG" id="cpv:cgd4_1960"/>
    <dbReference type="InParanoid" id="Q5CR62"/>
    <dbReference type="OMA" id="MNIVKDY"/>
    <dbReference type="OrthoDB" id="206053at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071566">
        <property type="term" value="F:UFM1 activating enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071569">
        <property type="term" value="P:protein ufmylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00757">
        <property type="entry name" value="ThiF_MoeB_HesA_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045886">
        <property type="entry name" value="ThiF/MoeB/HesA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000594">
        <property type="entry name" value="ThiF_NAD_FAD-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035985">
        <property type="entry name" value="Ubiquitin-activating_enz"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953">
        <property type="entry name" value="UBIQUITIN-ACTIVATING ENZYME E1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10953:SF9">
        <property type="entry name" value="UBIQUITIN-LIKE MODIFIER-ACTIVATING ENZYME 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00899">
        <property type="entry name" value="ThiF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69572">
        <property type="entry name" value="Activating enzymes of the ubiquitin-like proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="THIF-type NAD/FAD binding fold" evidence="9">
        <location>
            <begin position="28"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="302"/>
            <end position="323"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="302"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00016279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87945.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="370" mass="42176" checksum="1852A9FE8C31D54F" modified="2005-04-12" version="1" fragment="single">YLSDYNFFVTAKEMDRNDADENSIDERYSRLTALENMGVVDDYSLIMKKTIFVIGVGGVGSVVVEMLTRCGVGKLIIVDFDIVELSNMNRMFYNMNHIGMYKTDACVDTLKLINPKINIEKYNINIVEDYSIFYNIFKTKKIDLLVSCVDNYSARSIISQVCNEFDLVWFESGISENAISGHIQFVIPGMTACYCCAPPLVNFESNFSEDKINSIVMNSENENNSKKLSSRTCAASLSTTTSVIAGILVNNILKYFLGFGENSNFLGYHMIDDYFPRYSIIPNKECIDKWCRLRQKEKEYNKNEKTKNKSPYKEEPSRSNVSNGELLENYSNFEVIESDIHMESSKNLLESLNNLSISELINKLDEVSSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR87</accession>
    <name>Q5CR87_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">GTpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_1700</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87950.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625765.1">
        <property type="nucleotide sequence ID" value="XM_625765.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR87"/>
    <dbReference type="FunCoup" id="Q5CR87">
        <property type="interactions" value="450"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR87"/>
    <dbReference type="GeneID" id="3372766"/>
    <dbReference type="KEGG" id="cpv:cgd4_1700"/>
    <dbReference type="InParanoid" id="Q5CR87"/>
    <dbReference type="OMA" id="EWKNDVM"/>
    <dbReference type="OrthoDB" id="415015at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd01897">
        <property type="entry name" value="NOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1190">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031167">
        <property type="entry name" value="G_OBG"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006073">
        <property type="entry name" value="GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024926">
        <property type="entry name" value="NOG1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041623">
        <property type="entry name" value="NOG1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010674">
        <property type="entry name" value="NOG1_Rossman_fold_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012973">
        <property type="entry name" value="NOG_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45759">
        <property type="entry name" value="NUCLEOLAR GTP-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06858">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17835">
        <property type="entry name" value="NOG1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08155">
        <property type="entry name" value="NOGCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF038919">
        <property type="entry name" value="NOG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00326">
        <property type="entry name" value="GTP1OBG"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51710">
        <property type="entry name" value="G_OBG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="OBG-type G" evidence="7">
        <location>
            <begin position="162"/>
            <end position="346"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="609"/>
            <end position="681"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51710"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87950.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="681" mass="78574" checksum="EB00482CFBF8B49C" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRA4</accession>
    <name>Q5CRA4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3590</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626282.1">
        <property type="nucleotide sequence ID" value="XM_626282.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRA4"/>
    <dbReference type="GeneID" id="3373106"/>
    <dbReference type="KEGG" id="cpv:cgd5_3590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3590"/>
    <dbReference type="InParanoid" id="Q5CRA4"/>
    <dbReference type="OMA" id="FTEIMAI"/>
    <dbReference type="OrthoDB" id="337499at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009248">
        <property type="entry name" value="SbmA_BacA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05992">
        <property type="entry name" value="SbmA_BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="70"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="135"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="171"/>
            <end position="189"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="246"/>
            <end position="268"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="338" mass="39808" checksum="F16045E0CB609593" modified="2005-04-12" version="1">MISPYLFNKKYALRAYPLIIVLLAMMWIETGLNIKMTKIFGDFNQRLSDCESKSSDCTMNEMFKFALNNFALNFLIISFLRCLTSYLVNVFIFYWRQALTEYYLKSWNLISSVEGASQRVQEDTARWAKQLRLTIFEIVSAGMTFIKIIPELIAVSSAIPEIFILGKIKNGIIYPPFIIFGIQVIILAFSSYKLPYLHFENQKLEAKYRKVLALNEDSEHNVDSKELESIYEHLTRNYYSTFKCTFFFQYLYVSANEIAFFVGNIFLWPSFFHGSMTVKIYYTVQKFMGDMLFVFMIIQERWRGFTELMSVYRRLRTFEDEISKAAKEGVQLKEIDLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRK7</accession>
    <name>Q5CRK7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87966.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626179.1">
        <property type="nucleotide sequence ID" value="XM_626179.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373148"/>
    <dbReference type="KEGG" id="cpv:cgd5_2420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2420"/>
    <dbReference type="InParanoid" id="Q5CRK7"/>
    <dbReference type="OrthoDB" id="344304at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="364"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="601"/>
            <end position="624"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="646"/>
            <end position="680"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="727"/>
            <end position="759"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="781"/>
            <end position="802"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="918"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1234"/>
            <end position="1276"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="255"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="445"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="601"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="664"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="727"/>
            <end position="741"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1238"/>
            <end position="1252"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1263"/>
            <end position="1272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87966.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1304" mass="139714" checksum="9CE9C6BDD1311F9E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRP1</accession>
    <name>Q5CRP1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein with forkhead associated (FHA) domain within N-terminal region and possible central coiled coil domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_2050</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88064.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626145.1">
        <property type="nucleotide sequence ID" value="XM_626145.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRP1"/>
    <dbReference type="GeneID" id="3373263"/>
    <dbReference type="KEGG" id="cpv:cgd5_2050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2050"/>
    <dbReference type="InParanoid" id="Q5CRP1"/>
    <dbReference type="OMA" id="HTFFIST"/>
    <dbReference type="OrthoDB" id="1305878at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47458">
        <property type="entry name" value="SMAD/FHA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47458:SF1">
        <property type="entry name" value="SMAD_FHA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FHA" evidence="3">
        <location>
            <begin position="42"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="166"/>
            <end position="302"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="391"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="180"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="210"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="255"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88064.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="770" mass="86404" checksum="7D5A37A9228E917B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRQ7</accession>
    <name>Q5CRQ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_1860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626129.1">
        <property type="nucleotide sequence ID" value="XM_626129.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRQ7"/>
    <dbReference type="STRING" id="353152.Q5CRQ7"/>
    <dbReference type="GeneID" id="3373274"/>
    <dbReference type="KEGG" id="cpv:cgd5_1860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1860"/>
    <dbReference type="InParanoid" id="Q5CRQ7"/>
    <dbReference type="OMA" id="ANNINWM"/>
    <dbReference type="OrthoDB" id="10263222at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0090730">
        <property type="term" value="C:Las1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004519">
        <property type="term" value="F:endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000460">
        <property type="term" value="P:maturation of 5.8S rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000470">
        <property type="term" value="P:maturation of LSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007174">
        <property type="entry name" value="Las1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15002:SF0">
        <property type="entry name" value="RIBOSOMAL BIOGENESIS PROTEIN LAS1L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04031">
        <property type="entry name" value="Las1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="737" mass="86594" checksum="4D0C5B4947D619E3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRR3</accession>
    <name>Q5CRR3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved eukaryotic protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_1790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ISY1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88238.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626123.1">
        <property type="nucleotide sequence ID" value="XM_626123.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRR3"/>
    <dbReference type="FunCoup" id="Q5CRR3">
        <property type="interactions" value="441"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRR3"/>
    <dbReference type="GeneID" id="3373086"/>
    <dbReference type="KEGG" id="cpv:cgd5_1790"/>
    <dbReference type="InParanoid" id="Q5CRR3"/>
    <dbReference type="OMA" id="KWECRIV"/>
    <dbReference type="OrthoDB" id="1739576at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.660">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029012">
        <property type="entry name" value="Helix_hairpin_bin_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009360">
        <property type="entry name" value="Isy1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037200">
        <property type="entry name" value="Isy1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13021">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR ISY1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06246">
        <property type="entry name" value="Isy1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140102">
        <property type="entry name" value="ISY1 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88238.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="175" mass="20775" checksum="18D5FCCB3F0F75E3" modified="2005-04-12" version="1" fragment="single">FFFSRFEIMEEISNLAKKLRDCTMSDENEVRHLNSDINSLLKEKYKWECRIVELGGPNYRSRHGQYIESLGGISMPNSSLKIFGVAISLPEYKELLNYDDKTELSSKIVSEPPKVTICDAYYEEINKKEEDRIKTLEREKEIEFKKKKRFLEKEISVEYLLKLIDDKKKEIEQFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRU3</accession>
    <name>Q5CRU3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88101.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626093.1">
        <property type="nucleotide sequence ID" value="XM_626093.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRU3"/>
    <dbReference type="GeneID" id="3373280"/>
    <dbReference type="KEGG" id="cpv:cgd5_1460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1460"/>
    <dbReference type="InParanoid" id="Q5CRU3"/>
    <dbReference type="OMA" id="AYLMNDI"/>
    <dbReference type="OrthoDB" id="338276at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254894" evidence="1">
        <location>
            <begin position="26"/>
            <end position="715"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88101.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="715" mass="82350" checksum="093963B562FE1F5C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRU4</accession>
    <name>Q5CRU4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1450</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626092.1">
        <property type="nucleotide sequence ID" value="XM_626092.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRU4"/>
    <dbReference type="GeneID" id="3373282"/>
    <dbReference type="KEGG" id="cpv:cgd5_1450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1450"/>
    <dbReference type="InParanoid" id="Q5CRU4"/>
    <dbReference type="OMA" id="CISEMNL"/>
    <dbReference type="OrthoDB" id="343486at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254455" evidence="1">
        <location>
            <begin position="22"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="382" mass="43575" checksum="6B1522C6D4481C9C" modified="2005-04-12" version="1">MEFAKFVFLCYCILGINRVFGANDLSNFIESPNILDSRTFDLYEQNKNEYQSTILSSEASSSFINSGLLNSIENSININQETNERSNFNLTDPPHYDGSSELSENLVTFSNLLISPIMGKSTAILGELSFKYSLDGIRSGIIDSENHYSPANLVNKLFGPNGTKKNAIGLLRYGFLYALINEINNQFQKKIDFKLKLHPKLLIDPLKYDECVNLFTEANIHDTLFLTQKISKGIFEIICKNVIKNNYFIEMQSWDHHISKIISFIKENIQSIRGNSDILPKAIQITDLPKVPEIKVSGTEIKMRYLNIVKSIDAIKKKEYSLFNSLIFTKKMAVKISTQYLPNGRELVQKCIEIIKSENPALMREVYQREKIEQICKISMGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRV7</accession>
    <name>Q5CRV7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_1300</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88118.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626079.1">
        <property type="nucleotide sequence ID" value="XM_626079.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRV7"/>
    <dbReference type="GeneID" id="3373060"/>
    <dbReference type="KEGG" id="cpv:cgd5_1300"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1300"/>
    <dbReference type="InParanoid" id="Q5CRV7"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="248"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="275"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="304"/>
            <end position="321"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88118.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="392" mass="46494" checksum="6B4C0C31DF41BA38" modified="2005-04-12" version="1">MQINHSNYRIKFYSNNLNSTFTNLLGNNVETIIRTGTKLDFFAFTQSPNRKENYLKKCNTNLKKLSFRKEINFLCSFKNILNSTKSLSTYQDFDFLELIYINENQHLVKEQRRLRRVINIKTHRNCILPLFDLLINHVNRLQLSDLNFQHIKNLNTLRQDHSSPGIEIKNIDKYIIHDINNFFGLKKGVQLFSNHENNKVSIILLKFLNEYYKICSKSLIELAIQVIRIMNINILRSKYISINHLSEIIIIALSVINICFDIFFYIFNWKSIPKMGMAIEMIHLILTTLYFYGSEGLIKEFFNIYAQLLYYSYIYRIIFILQCKFTNKYNKFQVTEIIRTQLKQIFYSISNDISSMISSSEFESICTKLGIDIFDQSNLVNQSLYTYFVSKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS24</accession>
    <name>Q5CS24_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">MJ1157-like thiouridine synthase (Pploop atpase) plus Zn ribbon. involved in RNA metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88167.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626012.1">
        <property type="nucleotide sequence ID" value="XM_626012.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS24"/>
    <dbReference type="FunCoup" id="Q5CS24">
        <property type="interactions" value="209"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS24"/>
    <dbReference type="GeneID" id="3373174"/>
    <dbReference type="KEGG" id="cpv:cgd5_520"/>
    <dbReference type="InParanoid" id="Q5CS24"/>
    <dbReference type="OMA" id="KPVRGIC"/>
    <dbReference type="OrthoDB" id="198857at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002144">
        <property type="term" value="C:cytosolic tRNA wobble base thiouridylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002143">
        <property type="term" value="P:tRNA wobble position uridine thiolation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01713">
        <property type="entry name" value="CTU1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056369">
        <property type="entry name" value="CTU1-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011063">
        <property type="entry name" value="TilS/TtcA_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035107">
        <property type="entry name" value="tRNA_thiolation_TtcA_Ctu1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807">
        <property type="entry name" value="ATPASES OF THE PP SUPERFAMILY-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11807:SF12">
        <property type="entry name" value="CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01171">
        <property type="entry name" value="ATP_bind_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004976">
        <property type="entry name" value="ATPase_YdaO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52402">
        <property type="entry name" value="Adenine nucleotide alpha hydrolases-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="tRNA(Ile)-lysidine/2-thiocytidine synthase N-terminal" evidence="2">
        <location>
            <begin position="12"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF01171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88167.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="306" mass="35281" checksum="AC46CD9EEB82778B" modified="2005-04-12" version="1">MKYSMFKRGNRVGVCISGGKDSSVLLNVLYELNKRKDYGIELELIAVDEGIKGYRDDSLEVVKYQQEYYNCPLTILSFKDMFNTTMDEIQSKSSKSNSCTYCGVFRRKALDIGSYKVNADVICTGHSCDDTCETLLLNILRGDFNRLRRCINPITNNEITTTKDQMQNHDSQNEAFLNIKPRVKPLMYCYEKEIVLYAHYLNLKYFSTECTYSVDAYRGVSREFIRKIQSFDYKYSFNMILAAQELNLEQSNSSPNYIARKCTICGYISSSTICNGCNLINALKHDNPNLILKNQRQKKKILLQES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS26</accession>
    <name>Q5CS26_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">tRNA (guanine(9)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="1">2.1.1.221</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_500</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="5">
            <text>guanosine(9) in tRNA + S-adenosyl-L-methionine = N(1)-methylguanosine(9) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43156"/>
            <dbReference type="Rhea" id="RHEA-COMP:10367"/>
            <dbReference type="Rhea" id="RHEA-COMP:10368"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:73542"/>
            <dbReference type="ChEBI" id="CHEBI:74269"/>
            <dbReference type="EC" id="2.1.1.221"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.221" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88168.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626010.1">
        <property type="nucleotide sequence ID" value="XM_626010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS26"/>
    <dbReference type="STRING" id="353152.Q5CS26"/>
    <dbReference type="GeneID" id="3373175"/>
    <dbReference type="KEGG" id="cpv:cgd5_500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_500"/>
    <dbReference type="InParanoid" id="Q5CS26"/>
    <dbReference type="OMA" id="NHIFAFM"/>
    <dbReference type="OrthoDB" id="278300at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052905">
        <property type="term" value="F:tRNA (guanosine(9)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002939">
        <property type="term" value="P:tRNA N1-guanine methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18089">
        <property type="entry name" value="SPOUT_Trm10-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028564">
        <property type="entry name" value="MT_TRM10-typ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038459">
        <property type="entry name" value="MT_TRM10-typ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007356">
        <property type="entry name" value="tRNA_m1G_MeTrfase_euk"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563">
        <property type="entry name" value="TRNA (GUANINE-9-) METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13563:SF13">
        <property type="entry name" value="TRNA METHYLTRANSFERASE 10 HOMOLOG A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51675">
        <property type="entry name" value="SAM_MT_TRM10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase TRM10-type" evidence="6">
        <location>
            <begin position="33"/>
            <end position="244"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012797"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00048434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88168.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="246" mass="28228" checksum="E31DA7324A081971" modified="2005-04-12" version="1">MEFEISSENINDHVKCQIKKKTNDNRKNRNFKSNQDYLNNIGLGPTLIIDCDYDDKLSDRNLKSLVVQLSISYSCIRKSKIPLKMIICGVSQRLKQGLYKTLAESWLGVEILSDKVNKVVSDRYSDKNSNYEIIYLSADSNNVLTSKQDQDEYGNSSNQGFNNKQIFIIGGIIDRNKYKNISKLRAEEFNIKTAKLPIIESGITLCSNQVLTVNHVIECIVKYNETCNWYTTFDSILPKRKKDNTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS31</accession>
    <name>Q5CS31_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Possible ring domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88265.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626005.1">
        <property type="nucleotide sequence ID" value="XM_626005.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS31"/>
    <dbReference type="GeneID" id="3373312"/>
    <dbReference type="KEGG" id="cpv:cgd5_450"/>
    <dbReference type="InParanoid" id="Q5CS31"/>
    <dbReference type="OMA" id="HTENGDN"/>
    <dbReference type="OrthoDB" id="6105938at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047134">
        <property type="entry name" value="RNF4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041:SF78">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23041">
        <property type="entry name" value="RING FINGER DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14634">
        <property type="entry name" value="zf-RING_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="260"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="81"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="165"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="83"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="167"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88265.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="329" mass="36824" checksum="0C057A22CF8CC0AC" modified="2005-04-12" version="1" fragment="single">IVNYTVILQILMTENNNNIIILSSSSSSESEGEQKRTGKIRKIKKIIQNKTTIEEGHTENGDNIEYSSNLSQHKNHNVTLTASSSLSSSSSSSSSSSSSSSSSSSSSSSSSSSSFQNNLLEDVYLVNEENNRTVIEQLIENKNDDSDDNEQVIEVIDCNSNSIKRANTNTSRRNNRISTRTNPYSTSSSSRGLFNISLNELSENTTNNFPLFGVYSNIINFLNSTMNPCNMNNHQNKNQVIEKPVELTQEEKEKAAKFTCPICLEDWDNIMSRTLTINQFLPNIRTPVVITRCGHHFCLNCAGNLVQRKQKCPRCRGNLTKKDFINFYV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSF2</accession>
    <name>Q5CSF2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628115.1">
        <property type="nucleotide sequence ID" value="XM_628115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSF2"/>
    <dbReference type="GeneID" id="3371713"/>
    <dbReference type="KEGG" id="cpv:cgd1_2990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2990"/>
    <dbReference type="InParanoid" id="Q5CSF2"/>
    <dbReference type="OrthoDB" id="329139at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2380.10">
        <property type="entry name" value="CGI121/TPRKB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036504">
        <property type="entry name" value="CGI121/TPRKB_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="83"/>
            <end position="110"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="138" mass="16163" checksum="A706754DE6BDF63C" modified="2005-04-12" version="1">MASIQEKLQRFTLGESLKDEFVSICLVRDIHNSKELLEILMKKNHPKLLELTQDQSRQFVILMNARMVGSFPDVSFPKLTSKIFFFFFLNIYFQIYNLEHILISLSICLLKKKFQSKTKTKAFETEVIYNMSPSTNVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSH1</accession>
    <name>Q5CSH1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Ro ribonucleoprotein-binding protein 1, RNA binding protein with 3x RRM domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd1_2730</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88352.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628096.1">
        <property type="nucleotide sequence ID" value="XM_628096.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSH1"/>
    <dbReference type="FunCoup" id="Q5CSH1">
        <property type="interactions" value="57"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSH1"/>
    <dbReference type="GeneID" id="3371720"/>
    <dbReference type="KEGG" id="cpv:cgd1_2730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2730"/>
    <dbReference type="InParanoid" id="Q5CSH1"/>
    <dbReference type="OMA" id="RIHISDH"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000380">
        <property type="term" value="P:alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006376">
        <property type="term" value="P:mRNA splice site recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000381">
        <property type="term" value="P:regulation of alternative mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12374">
        <property type="entry name" value="RRM_UHM_SPF45_PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.330:FF:000382">
        <property type="entry name" value="G-patch domain-containing protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051974">
        <property type="entry name" value="PUF60_regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330:SF1">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47330">
        <property type="entry name" value="POLY(U)-BINDING-SPLICING FACTOR PUF60-B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 6" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="290"/>
            <end position="366"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="424"/>
            <end position="503"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="8">
        <location>
            <begin position="598"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="383"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="10"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="38"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="95"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="125"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="180"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="207"/>
            <end position="219"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="232"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="268"/>
            <end position="282"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88352.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="693" mass="73589" checksum="8832E149EE029913" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSK4</accession>
    <name>Q5CSK4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">SANT domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_2330</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628063.1">
        <property type="nucleotide sequence ID" value="XM_628063.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSK4"/>
    <dbReference type="STRING" id="353152.Q5CSK4"/>
    <dbReference type="GeneID" id="3371668"/>
    <dbReference type="KEGG" id="cpv:cgd1_2330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2330"/>
    <dbReference type="InParanoid" id="Q5CSK4"/>
    <dbReference type="OrthoDB" id="2193595at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042826">
        <property type="term" value="F:histone deacetylase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.60:FF:000012">
        <property type="entry name" value="Metastasis-associated 1 family, member 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040138">
        <property type="entry name" value="MIER/MTA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865:SF28">
        <property type="entry name" value="ELM2 DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10865">
        <property type="entry name" value="METASTASIS-ASSOCIATED PROTEIN AND MESODERM INDUCTION EARLY RESPONSE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="SANT" evidence="6">
        <location>
            <begin position="212"/>
            <end position="263"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="280" mass="32103" checksum="C91B33EE5FC6A39A" modified="2005-04-12" version="1">MNIVQNMKKNSAGVTLNKSKNFSSHKYSFQGTQNQVDKTAVIKGINSQIQAKTNDQIPKKNVTENSNLNDSELNTISCSNNNSDSSSSAFNSTFHLPYNFKEVPEPKIRSELMKKKISKLESYLSLCEDLYLGGISKTQTVSEIFQSLIISHNIDHEEQFNAFLKRQSINNGFTKSSTKANSKNSNLQEPITNAENIISPLQLLTHPFRNKEVIDLWGPHEVILFECGVCKYGKEFDKIQRIIKTKTTKEIVDFYYCIWKRTSRYKAWKSNRQLSEYIFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSP5</accession>
    <name>Q5CSP5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TB2/DP1/HVA22 family integral membrane protein that may be involved in membrane trafficking, 3x transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_1830</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Membrane</location>
            <topology evidence="1 6">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the DP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88414.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628022.1">
        <property type="nucleotide sequence ID" value="XM_628022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSP5"/>
    <dbReference type="FunCoup" id="Q5CSP5">
        <property type="interactions" value="44"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSP5"/>
    <dbReference type="GeneID" id="3371665"/>
    <dbReference type="KEGG" id="cpv:cgd1_1830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1830"/>
    <dbReference type="InParanoid" id="Q5CSP5"/>
    <dbReference type="OMA" id="DTQYWVV"/>
    <dbReference type="OrthoDB" id="10009287at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004345">
        <property type="entry name" value="TB2_DP1_HVA22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300">
        <property type="entry name" value="HVA22-LIKE PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12300:SF161">
        <property type="entry name" value="RECEPTOR EXPRESSION-ENHANCING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03134">
        <property type="entry name" value="TB2_DP1_HVA22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="57"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU362006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88414.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="205" mass="23752" checksum="CCF231654AE6C1C8" modified="2005-04-12" version="1">MTNNWRMLNSNKNPESLSVFSGLSIDFEAYCKEIDSKLVNISWIKPASESLGCRPCYLMFGAVFILVLIVSMGYAGALICNLVGFIYPAYMSFKALETPGKLDDKQWLTYWVVYAIFNILEVFIDIILFWMPFYYLFKLCFLFWLFLPQTTGAVTLYNNIFRPLLIRFEKKIDNTIENVLDVSNSARLVAQRYSKKLLEGSEKIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSQ8</accession>
    <name>Q5CSQ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">PHD finger containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_1690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628009.1">
        <property type="nucleotide sequence ID" value="XM_628009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSQ8"/>
    <dbReference type="STRING" id="353152.Q5CSQ8"/>
    <dbReference type="GeneID" id="3371639"/>
    <dbReference type="KEGG" id="cpv:cgd1_1690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1690"/>
    <dbReference type="InParanoid" id="Q5CSQ8"/>
    <dbReference type="OMA" id="TEICEMS"/>
    <dbReference type="OrthoDB" id="20839at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="442"/>
            <end position="492"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="660" mass="76135" checksum="D8905E70479D17A8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT01</accession>
    <name>Q5CT01_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal peptide, large protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_640</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627916.1">
        <property type="nucleotide sequence ID" value="XM_627916.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT01"/>
    <dbReference type="STRING" id="353152.Q5CT01"/>
    <dbReference type="GeneID" id="3371541"/>
    <dbReference type="KEGG" id="cpv:cgd1_640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_640"/>
    <dbReference type="InParanoid" id="Q5CT01"/>
    <dbReference type="OrthoDB" id="342055at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254219" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="420"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="922"/>
            <end position="954"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1232"/>
            <end position="1272"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="687"/>
            <end position="714"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="926"/>
            <end position="936"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="937"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1235"/>
            <end position="1255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1272" mass="147429" checksum="FDB0581552537B5A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT30</accession>
    <name>Q5CT30_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_270</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88605.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627887.1">
        <property type="nucleotide sequence ID" value="XM_627887.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT30"/>
    <dbReference type="STRING" id="353152.Q5CT30"/>
    <dbReference type="GeneID" id="3371529"/>
    <dbReference type="KEGG" id="cpv:cgd1_270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_270"/>
    <dbReference type="InParanoid" id="Q5CT30"/>
    <dbReference type="OMA" id="GTEGIPF"/>
    <dbReference type="OrthoDB" id="1306014at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd20908">
        <property type="entry name" value="SUF4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215:SF0">
        <property type="entry name" value="BUB3-INTERACTING AND GLEBS MOTIF-CONTAINING PROTEIN ZNF207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23215">
        <property type="entry name" value="ZINC FINGER PROTEIN 207"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00355">
        <property type="entry name" value="ZnF_C2H2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="15"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88605.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="145" mass="16921" checksum="8AA6018E88752589" modified="2005-04-12" version="1">MGRKKRKIAEIKPFCYYCNREFGDEKVLKQHQKVRHLKCLHCSRKLSTVSGLIVHMLQVHKETLSRIPNAIPGRDIPDIVINGMKGVPSELIEERIKKQNVEIDIQKNLKSYNPHGNKMMALMNEVATNFVKEHSKFKFSNYLEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT86</accession>
    <name>Q5CT86_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">MAL7P1.13-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_4010</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626583.1">
        <property type="nucleotide sequence ID" value="XM_626583.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT86"/>
    <dbReference type="GeneID" id="3373493"/>
    <dbReference type="KEGG" id="cpv:cgd2_4010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4010"/>
    <dbReference type="InParanoid" id="Q5CT86"/>
    <dbReference type="OMA" id="HAGLEME"/>
    <dbReference type="OrthoDB" id="298686at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038835">
        <property type="entry name" value="Giardin_beta-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37027:SF2">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_148, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR37027">
        <property type="entry name" value="KDE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="51"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="139"/>
            <end position="166"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="282" mass="33104" checksum="73C862A5A843013E" modified="2005-04-12" version="1">MHNTLSYSKKLTSGSGANVYHDDRINRLSQRLNSIHNGLDLDRSTKHYDKLAEMEANMKKFEDDMNRKYDEGMKKVNELKSTLMSLKSENREIYSSYCMDHETKANSIENQNYLNPKSDILQAERRLNELLQSEIFSRKSMEQRLIEIIDERMDRLRNEISKKDVEREELDSCVKRFVEVDIVRLGNAIKSEVDKCQAIENNILSQLKEEIEKLSYLINDEVNTRQQSIDTLLDLMENLVQQITIDTRNERSERQNSEDTLLKLLEESLNRIQLATSSITKF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTD4</accession>
    <name>Q5CTD4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626535.1">
        <property type="nucleotide sequence ID" value="XM_626535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTD4"/>
    <dbReference type="GeneID" id="3373756"/>
    <dbReference type="KEGG" id="cpv:cgd2_3480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3480"/>
    <dbReference type="InParanoid" id="Q5CTD4"/>
    <dbReference type="OrthoDB" id="343986at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="530"/>
            <end position="553"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="573"/>
            <end position="597"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="617"/>
            <end position="640"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="659" mass="77077" checksum="A5A0291560326229" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTD9</accession>
    <name>Q5CTD9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein SDA1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_3430</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Required for 60S pre-ribosomal subunits export to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the SDA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626530.1">
        <property type="nucleotide sequence ID" value="XM_626530.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTD9"/>
    <dbReference type="STRING" id="353152.Q5CTD9"/>
    <dbReference type="GeneID" id="3373759"/>
    <dbReference type="KEGG" id="cpv:cgd2_3430"/>
    <dbReference type="InParanoid" id="Q5CTD9"/>
    <dbReference type="OMA" id="AMYKTYK"/>
    <dbReference type="OrthoDB" id="2196187at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042273">
        <property type="term" value="P:ribosomal large subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000055">
        <property type="term" value="P:ribosomal large subunit export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027312">
        <property type="entry name" value="Sda1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012977">
        <property type="entry name" value="SDA1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730">
        <property type="entry name" value="HSDA/SDA1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12730:SF0">
        <property type="entry name" value="PROTEIN SDA1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08158">
        <property type="entry name" value="SDA1_HEAT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="1" id="KW-0653">Protein transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="780"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 N-terminal" evidence="5">
        <location>
            <begin position="59"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="domain" description="SDA1 N-terminal" evidence="5">
        <location>
            <begin position="199"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="615"/>
            <end position="647"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="682"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="2">
        <location>
            <begin position="285"/>
            <end position="352"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="615"/>
            <end position="638"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="711"/>
            <end position="732"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU365057"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="801" mass="91692" checksum="14B69C8A5252642D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTI5</accession>
    <name>Q5CTI5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_2860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626484.1">
        <property type="nucleotide sequence ID" value="XM_626484.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTI5"/>
    <dbReference type="GeneID" id="3373704"/>
    <dbReference type="KEGG" id="cpv:cgd2_2860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2860"/>
    <dbReference type="InParanoid" id="Q5CTI5"/>
    <dbReference type="OrthoDB" id="342523at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="28"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="46"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="47"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="189" mass="21437" checksum="AA8C92CD67F78F8B" modified="2005-04-12" version="1">MSTIFRFPPTSSIAISAISKISELSKENIPSTRSLQPNDEIQLNSKVSERSNFEEQAKAEKTPNNAIIKLLEDKKNEIKKNIENLANQLRRHIRQVEYIDSRICELRGEKIDLQSSRLISSLRLDSEHYQTSLSRLSTAINTGINTPNCELASSNEAEVRSNILSYKMEGDWLIVPEFKEVVSRTVNSS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTM1</accession>
    <name>Q5CTM1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_2460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88754.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626448.1">
        <property type="nucleotide sequence ID" value="XM_626448.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTM1"/>
    <dbReference type="GeneID" id="3373498"/>
    <dbReference type="KEGG" id="cpv:cgd2_2460"/>
    <dbReference type="InParanoid" id="Q5CTM1"/>
    <dbReference type="OMA" id="DINTPCQ"/>
    <dbReference type="OrthoDB" id="339074at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="124"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="128"/>
            <end position="143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88754.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="143" mass="16684" checksum="668EBFB8B25E7BAD" modified="2005-04-12" version="1">MQFWQFNIGSTNSIVNENLDEHSNENQNILKEYLFSLLNLPENLQKENPFFAHDLLSNSLNMNKRRLGISKRAICMANFGNLKNKNLGDDEDTTVQENKDTYNEDIEILEDDQESDIDYEYMNSGANEDYDELEDNTNDNDIM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTS5</accession>
    <name>Q5CTS5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ring domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_1750</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88801.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626394.1">
        <property type="nucleotide sequence ID" value="XM_626394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTS5"/>
    <dbReference type="FunCoup" id="Q5CTS5">
        <property type="interactions" value="137"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTS5"/>
    <dbReference type="GeneID" id="3373742"/>
    <dbReference type="KEGG" id="cpv:cgd2_1750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1750"/>
    <dbReference type="InParanoid" id="Q5CTS5"/>
    <dbReference type="OMA" id="ASWKQYL"/>
    <dbReference type="OrthoDB" id="302966at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000976">
        <property type="term" value="F:transcription cis-regulatory region binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045944">
        <property type="term" value="P:positive regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039739">
        <property type="entry name" value="MAG2/RNF10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983:SF9">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RNF10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12983">
        <property type="entry name" value="RING FINGER 10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="68"/>
            <end position="115"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88801.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="482" mass="55942" checksum="17CD4E7CA4E6D0DA" modified="2005-04-12" version="1">MSLISKKGPLSISSKFKFVQQNCRIFLLKDSNINRNTSVFSHDKMIFDWRNVGLIELIYFDSDEFIKCPICLDSDLLVPKISNCGHIYCWPCIIKLMNIILENDEYAKKFKCPICFSNVLLNELVSLRYQIVKKVQIGSEINLCLLYRNVSSPLIHFELNMKSSDGKVLLEKNEKGAQFQRIGLISDQNEILLHDLQMLRMRKLENERSGSDEEIGYIEECISIIENIFKLKGVTPRCERFSNDAFDMLLSHYGETELLEELEYRFINSSANYSNQYNMKDIFYFYQSFDGQLVYLEPFYVKVLQTEFGSIENLPKALLNVSVTSIKEFIINHQNIRKYKFLSHIPMGSKVYIVGINVLPYISTKTKEIFNAELEKRVNKRKTIKDMNYINLLYDEINHSSTGYEMINLNHANSCSNIEKNSQNSARATDSDFPTLEKYSNLKGKDKIGNAAFNKGNAQKLPHYKSNKDFYSPLTRTFRNAI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTW0</accession>
    <name>Q5CTW0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="13">26S proteasome regulatory subunit, S6a like AAA ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd2_1350</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88919.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626359.1">
        <property type="nucleotide sequence ID" value="XM_626359.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTW0"/>
    <dbReference type="FunCoup" id="Q5CTW0">
        <property type="interactions" value="444"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTW0"/>
    <dbReference type="GeneID" id="3373681"/>
    <dbReference type="KEGG" id="cpv:cgd2_1350"/>
    <dbReference type="InParanoid" id="Q5CTW0"/>
    <dbReference type="OMA" id="NKISHEH"/>
    <dbReference type="OrthoDB" id="9443236at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000009">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000076">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000037">
        <property type="entry name" value="26S protease regulatory subunit 6A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0472">Membrane</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 13" id="KW-0647">Proteasome</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="11" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="11">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="12">
        <location>
            <begin position="240"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="60"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK88919.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="461" mass="51754" checksum="51BA19F946F66B6C" modified="2005-04-12" version="1" fragment="single">TDLERVLNKIKLLWVGGNIIARVIFQIVELIYVVIPMSSEEGTDNWSAEEAVESVKTLSVSELQSRIRLLDGEIRLMKSESNRLKHELNQMNERIRSNTEKIKLNKQLPYLVANIVESLDFSDEQENEGEGMEFDGDKNDKCMVIKTSSRQTVFLPVIGLVPENELKPGDLVGVNKDSYLILDKLPPEYDSRVKAMEVDERPMEEYSDIGGLDKQIQELVEAIVLPMTHKERFEKIGIKPPKGVLMYGPPGTGKTLLARACAAQTKATFLKLAGPQLVQMFIGDGAKMVRDAFEIAREKAPSIIFIDELDAIGMKRFDSEHSGDREVQRTMLELLNQLDGFSSDDRVKVIAATNRPDTLDPALLRSGRLDRKVELPHPNEEARSRILQIHSRKMNVDLNDVNFQELSRSTDDFNGAQLKAVCVEAGMTALRRGATILCHEDYVEGIAAVLAKKKSPLSYFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTW6</accession>
    <name>Q5CTW6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DDHD domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_1280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626353.1">
        <property type="nucleotide sequence ID" value="XM_626353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTW6"/>
    <dbReference type="STRING" id="353152.Q5CTW6"/>
    <dbReference type="GeneID" id="3373580"/>
    <dbReference type="KEGG" id="cpv:cgd2_1280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1280"/>
    <dbReference type="InParanoid" id="Q5CTW6"/>
    <dbReference type="OMA" id="GITEHYI"/>
    <dbReference type="OrthoDB" id="69269at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004620">
        <property type="term" value="F:phospholipase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004177">
        <property type="entry name" value="DDHD_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058055">
        <property type="entry name" value="PA-PLA1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509:SF10">
        <property type="entry name" value="LD21067P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23509">
        <property type="entry name" value="PA-PL1 PHOSPHOLIPASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02862">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01127">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51043">
        <property type="entry name" value="DDHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DDHD" evidence="2">
        <location>
            <begin position="370"/>
            <end position="639"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="102"/>
            <end position="195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="665"/>
            <end position="685"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="110"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="122"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="142"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="685" mass="78386" checksum="80543430ACA1B781" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTX6</accession>
    <name>Q5CTX6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Zinc finger protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_1170</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ZPR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88937.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626343.1">
        <property type="nucleotide sequence ID" value="XM_626343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTX6"/>
    <dbReference type="FunCoup" id="Q5CTX6">
        <property type="interactions" value="393"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTX6"/>
    <dbReference type="GeneID" id="3373417"/>
    <dbReference type="KEGG" id="cpv:cgd2_1170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1170"/>
    <dbReference type="InParanoid" id="Q5CTX6"/>
    <dbReference type="OMA" id="FREVVIM"/>
    <dbReference type="OrthoDB" id="308464at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.420:FF:000001">
        <property type="entry name" value="Zinc finger protein ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000003">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.120.1040:FF:000006">
        <property type="entry name" value="Zinc finger protein zpr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.1040">
        <property type="entry name" value="ZPR1, A/B domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.420">
        <property type="entry name" value="ZPR1, zinc finger domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004457">
        <property type="entry name" value="Znf_ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040141">
        <property type="entry name" value="ZPR1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042451">
        <property type="entry name" value="ZPR1_A/B_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056180">
        <property type="entry name" value="ZPR1_jr_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042452">
        <property type="entry name" value="ZPR1_Znf1/2"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00310">
        <property type="entry name" value="ZPR1_znf"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10876:SF0">
        <property type="entry name" value="ZINC FINGER PROTEIN ZPR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22794">
        <property type="entry name" value="jr-ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03367">
        <property type="entry name" value="Zn_ribbon_ZPR1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00709">
        <property type="entry name" value="Zpr1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="5">
        <location>
            <begin position="20"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="domain" description="Zinc finger ZPR1-type" evidence="5">
        <location>
            <begin position="272"/>
            <end position="431"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008354"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00709"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88937.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="475" mass="53244" checksum="1DD2E2DD44A69D80" modified="2005-04-12" version="1">MGGNSEYSRDDDTGLTIIQSLCMNCHKEGETKLLLTSIPQFRDVILMSFECPHCGFKNNEIQSGGVLQDKGECIELVVTNVSDLDRQIVKSEFATISILEQELDIPPSTQKGVISTIEGIITKTIQGLSLNQEARIAQDQEVGGKIEKIINNLKGYLEGKGLPFTIKLDDPSGNSFIQNPIAPLVDHNMKRKLYDRTKEQLEEMGYYGVQNLKDDESQRISTYQPKKDNSNVTFSKGADIPEHLIPHYIDLNKSIEDQGELGSNEDRIKFDVPCPNCGNNGESDVCEIDIPGFRRCLIMAFVCNFCGIKTNELKPSGAYGELAKKWILTVESELDLNRDILKSDTASIEIPEIELEMGMGSLGSLFTTVEGMIVKITDSLKDCFTFQGDSATSEQKKGFQRVIEKLENLLEKKEKFTLIIDDAADHSFIGKRIVNGQFVQDDQQLKTEKYQRTDYQNETLGINDIKVENYSESEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUC1</accession>
    <name>Q5CUC1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein with 2x EF hands and 4 transmembrane regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd3_3420</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88999.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626893.1">
        <property type="nucleotide sequence ID" value="XM_626893.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUC1"/>
    <dbReference type="GeneID" id="3374121"/>
    <dbReference type="KEGG" id="cpv:cgd3_3420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3420"/>
    <dbReference type="InParanoid" id="Q5CUC1"/>
    <dbReference type="OMA" id="MNLMINE"/>
    <dbReference type="OrthoDB" id="191686at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="159"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="186"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="225"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="252"/>
            <end position="275"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="321"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="359"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="34"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88999.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="398" mass="45841" checksum="338A773990DC340F" modified="2005-04-12" version="1">MRRNNPDHKTPDSDKKELRSSKDSVVIYEDEYERENNQENENNKANHSEKSRNIDKGSKIKVNLGNTNGKKCDGEIESVSLKENGEPGQGNLSNDESAHLLKKERYEQKIDIQDKTDNELFQNLKKEAVNSFLEVKQDLLEQYLEFRDQVFKGQKSFRVLSQVATANLFLMGTLNCIFGLISINLLAIVISLYIISISSVVLIIEVSKKKRIKHIEIFVRTWFKFLELSVGRGSIQILLCTISLYLTQSTYFSLMSLFVGLTGILNIIFGILAASKLRKILNILKYYGSRDLEDLGIYNRDEISHSELGNIKISKDHDPEYKLKKIHRFFNALDEDGNGQINQDELFNGLKSLNFPFSISKSEIEIIFDHLDKDSDNMISIEDFEHWFISNKCPYFIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUI4</accession>
    <name>Q5CUI4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2710</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89055.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626830.1">
        <property type="nucleotide sequence ID" value="XM_626830.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUI4"/>
    <dbReference type="GeneID" id="3373966"/>
    <dbReference type="KEGG" id="cpv:cgd3_2710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2710"/>
    <dbReference type="InParanoid" id="Q5CUI4"/>
    <dbReference type="OMA" id="IASIQNC"/>
    <dbReference type="OrthoDB" id="941624at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="415"/>
            <end position="434"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="440"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="546"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="705"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="80"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="473"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="705"/>
            <end position="717"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89055.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="874" mass="98716" checksum="F96C7413E6A89340" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUU5</accession>
    <name>Q5CUU5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">U1 small nuclear ribonucleoprotein c like finger</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_1440</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89143.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626719.1">
        <property type="nucleotide sequence ID" value="XM_626719.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUU5"/>
    <dbReference type="STRING" id="353152.Q5CUU5"/>
    <dbReference type="GeneID" id="3373976"/>
    <dbReference type="KEGG" id="cpv:cgd3_1440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1440"/>
    <dbReference type="InParanoid" id="Q5CUU5"/>
    <dbReference type="OrthoDB" id="191651at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040023">
        <property type="entry name" value="WBP4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13173:SF10">
        <property type="entry name" value="WW DOMAIN-BINDING PROTEIN 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="3" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="6">
        <location>
            <begin position="11"/>
            <end position="42"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89143.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="225" mass="26591" checksum="2E2369CBBB3413B6" modified="2005-04-12" version="1">MRRNKEVNNKHYCQVCKIWIENHPNNIRSHQEGGRHNYNLRKLLKSENYRELQKKKDEEEVRKEFMKLQGVEQTSNREKKRIKLIDKEVRSGSSTTFGDNVFTANYTFDDSKNIFEKKDHNESHDKTNEMGIIGKWEEVKESESAFLGNITLEQQDHTQIPNPFKPIEGCVQIKKNSLSQKVYSCISDIEGSFEEQQFNEKSTSDYQKAKNEKIKIVFKSRKIPR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUU9</accession>
    <name>Q5CUU9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Pyrophosphate--fructose 6-phosphate 1-phosphotransferase</fullName>
            <ecNumber evidence="10">2.7.1.90</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">6-phosphofructokinase, pyrophosphate dependent</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">PPi-dependent phosphofructokinase</fullName>
            <shortName evidence="10">PPi-PFK</shortName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="10">Pyrophosphate-dependent 6-phosphofructose-1-kinase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd3_1400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="2 10">Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 10">
            <text>beta-D-fructose 6-phosphate + diphosphate = beta-D-fructose 1,6-bisphosphate + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13613"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:32966"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:57634"/>
            <dbReference type="EC" id="2.7.1.90"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 10">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="activity regulation">
        <text evidence="10">Non-allosteric.</text>
    </comment>
    <comment type="pathway">
        <text evidence="10">Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 3/4.</text>
    </comment>
    <comment type="subunit">
        <text evidence="10">Tetramer of two alpha (regulatory) and two beta (catalytic) chains.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="10">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="10">Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.90" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89146.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626715.1">
        <property type="nucleotide sequence ID" value="XM_626715.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CUU9"/>
    <dbReference type="STRING" id="353152.Q5CUU9"/>
    <dbReference type="GeneID" id="3373979"/>
    <dbReference type="KEGG" id="cpv:cgd3_1400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1400"/>
    <dbReference type="InParanoid" id="Q5CUU9"/>
    <dbReference type="OMA" id="MICSGRH"/>
    <dbReference type="OrthoDB" id="537915at2759"/>
    <dbReference type="UniPathway" id="UPA00109">
        <property type="reaction ID" value="UER00182"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003872">
        <property type="term" value="F:6-phosphofructokinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0047334">
        <property type="term" value="F:diphosphate-fructose-6-phosphate 1-phosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006002">
        <property type="term" value="P:fructose 6-phosphate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009749">
        <property type="term" value="P:response to glucose"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.450">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.460">
        <property type="entry name" value="Phosphofructokinase domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.480">
        <property type="entry name" value="Phosphofructokinase, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01980">
        <property type="entry name" value="Phosphofructokinase_II_Long"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022953">
        <property type="entry name" value="ATP_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011183">
        <property type="entry name" value="PfpB_PPi_PFK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000023">
        <property type="entry name" value="Phosphofructokinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035966">
        <property type="entry name" value="PKF_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02477">
        <property type="entry name" value="PFKA_PPi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF005482">
        <property type="entry name" value="PRK07085.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43650">
        <property type="entry name" value="PYROPHOSPHATE--FRUCTOSE 6-PHOSPHATE 1-PHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43650:SF1">
        <property type="entry name" value="PYROPHOSPHATE--FRUCTOSE 6-PHOSPHATE 1-PHOSPHOTRANSFERASE SUBUNIT BETA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00365">
        <property type="entry name" value="PFK"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00476">
        <property type="entry name" value="PHFRCTKINASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53784">
        <property type="entry name" value="Phosphofructokinase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 10" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8 10" id="KW-0324">Glycolysis</keyword>
    <keyword evidence="6 10 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="7 10" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 10" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Phosphofructokinase" evidence="11">
        <location>
            <begin position="104"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphofructokinase" evidence="11">
        <location>
            <begin position="799"/>
            <end position="920"/>
        </location>
    </feature>
    <feature type="active site" description="Proton acceptor" evidence="10">
        <location>
            <position position="236"/>
        </location>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="112"/>
        </location>
        <ligand>
            <name>diphosphate</name>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="206"/>
        </location>
        <ligand>
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
            <note>catalytic</note>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="234"/>
            <end position="236"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="281"/>
            <end position="283"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <position position="342"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="binding site" evidence="10">
        <location>
            <begin position="442"/>
            <end position="445"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <feature type="site" description="Important for catalytic activity and substrate specificity; stabilizes the transition state when the phosphoryl donor is PPi; prevents ATP from binding by mimicking the alpha-phosphate group of ATP" evidence="10">
        <location>
            <position position="207"/>
        </location>
    </feature>
    <feature type="site" description="Important for catalytic activity; stabilizes the transition state when the phosphoryl donor is PPi" evidence="10">
        <location>
            <position position="233"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00003138"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023152"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03185"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89146.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1327" mass="148083" checksum="835C001AE9E3AE21" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUW2</accession>
    <name>Q5CUW2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">RING domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1260</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89155.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626702.1">
        <property type="nucleotide sequence ID" value="XM_626702.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUW2"/>
    <dbReference type="STRING" id="353152.Q5CUW2"/>
    <dbReference type="GeneID" id="3373988"/>
    <dbReference type="KEGG" id="cpv:cgd3_1260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1260"/>
    <dbReference type="InParanoid" id="Q5CUW2"/>
    <dbReference type="OMA" id="TFCRINI"/>
    <dbReference type="OrthoDB" id="10261999at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045194">
        <property type="entry name" value="MGRN1/RNF157-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996">
        <property type="entry name" value="MAHOGUNIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22996:SF0">
        <property type="entry name" value="RE60872P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13920">
        <property type="entry name" value="zf-C3HC4_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="2">
        <location>
            <begin position="214"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89155.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="266" mass="30545" checksum="AC6219B90FA4A920" modified="2005-04-12" version="1">MGNLIERENRGVQYPVREQITRRLSNTEYIFSEALNRNDPRISLNNEKQEKKLISVSKSKAIQNQCHINGLSIRYIPSLKRMRFEYDCIQDSILNIYNSNSLEENLINTEKPIFSHIVPKSLNKEFQCDLKSDLKQNFVLEIKPKSSSTNNTETIQLTFCEQIPKKANNALESQIEIKRQCVLYNGKAFEIQNIFGLSNKSSKASKNDEDSEKCVICLTNNRETILLPCRHACLCKICSNTLFKNTQDCPICRNSVLGVVNIEDSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUZ8</accession>
    <name>Q5CUZ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">RSC6/BAF60A ortholog with a SWIB domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_840</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626666.1">
        <property type="nucleotide sequence ID" value="XM_626666.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUZ8"/>
    <dbReference type="STRING" id="353152.Q5CUZ8"/>
    <dbReference type="GeneID" id="3374128"/>
    <dbReference type="KEGG" id="cpv:cgd3_840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_840"/>
    <dbReference type="InParanoid" id="Q5CUZ8"/>
    <dbReference type="OMA" id="VMDSKHH"/>
    <dbReference type="OrthoDB" id="10263741at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd10567">
        <property type="entry name" value="SWIB-MDM2_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.245.10">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019835">
        <property type="entry name" value="SWIB_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036885">
        <property type="entry name" value="SWIB_MDM2_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003121">
        <property type="entry name" value="SWIB_MDM2_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13844">
        <property type="entry name" value="SWI/SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02201">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00151">
        <property type="entry name" value="SWIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47592">
        <property type="entry name" value="SWIB/MDM2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51925">
        <property type="entry name" value="SWIB_MDM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DM2" evidence="1">
        <location>
            <begin position="165"/>
            <end position="245"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51925"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="437" mass="51253" checksum="BBE9869EFF24D5D8" modified="2005-04-12" version="1">MARIPECIKEFSQEQYNQYENLLEYERLLDESILQQRYSLSDVWLTLMDDKSIRCYRKKLRVHIFNTYESQKPTDAELESFSFDNDWTRKVPPSWTLKILGSIIQGDAYQPRFTSIFSKIIIQLSETETIIWDKKTSPTPECDGLEIHRIGDEERDIDILFFLDYRTPHYSLSPQLEEFMGTSLANLPSIVKRIWQYVEMKGLQNSKASHDSIMIDEYLGKLLSVDTEHVLLKDVPDLLKQHLLPPKPIKIRHRLALKGDWIDNESTYDFTIDLTENVPGDITLWLPNMSTRIQESGEFSNINKALEELYHKNQSILSKIYSSCNKINFYQGFANDPVDFIHSLLTTKHFQLYGNNSINNILSDPNAIYEYQIADKYAEYYRQPWVPRAIEKYLSCKNKNFEERVNKTVASVSACEKIRRRSGFGQDQRIQSHPNQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV37</accession>
    <name>Q5CV37_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_420</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89220.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626627.1">
        <property type="nucleotide sequence ID" value="XM_626627.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV37"/>
    <dbReference type="GeneID" id="3373994"/>
    <dbReference type="KEGG" id="cpv:cgd3_420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_420"/>
    <dbReference type="InParanoid" id="Q5CV37"/>
    <dbReference type="OMA" id="ENDFIHI"/>
    <dbReference type="OrthoDB" id="341077at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1910">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027482">
        <property type="entry name" value="Sec1-like_dom2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89220.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="891" mass="102531" checksum="88A69BC735E588AB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV73</accession>
    <name>Q5CV73_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_5170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627396.1">
        <property type="nucleotide sequence ID" value="XM_627396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV73"/>
    <dbReference type="GeneID" id="3374234"/>
    <dbReference type="KEGG" id="cpv:cgd8_5170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5170"/>
    <dbReference type="InParanoid" id="Q5CV73"/>
    <dbReference type="OMA" id="ANRRMIV"/>
    <dbReference type="OrthoDB" id="342981at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="19"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="221" mass="25432" checksum="5CD6FE484EF9BFFB" modified="2005-04-12" version="1">MDLDSIISKKSEHNEEKKCSSLSEKVQFCQSKMLKLEEELNTQEESNKEDENRYPYRRMIISNIYTLLGELASQAQSRMAKRLEAQYIKSQKFKTRERKSNLSSELAGIDYSSLDQKSYNSYDGSLDHDQDLDPGMDELTPEMEKAAQELLNHFTSDLDALRESQNQLHEISSLMSFFSSKIQEQSEICSTILADANDAVDYLDESKIYLEKMEEAYGARG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV78</accession>
    <name>Q5CV78_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_5110</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627391.1">
        <property type="nucleotide sequence ID" value="XM_627391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV78"/>
    <dbReference type="GeneID" id="3374231"/>
    <dbReference type="KEGG" id="cpv:cgd8_5110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5110"/>
    <dbReference type="InParanoid" id="Q5CV78"/>
    <dbReference type="OMA" id="SKEDHIS"/>
    <dbReference type="OrthoDB" id="341614at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="117"/>
            <end position="158"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="163" mass="19457" checksum="130DD83C6911404A" modified="2005-04-12" version="1">MYSNNRRKSGRKCVLDTDISPVLEKRIRAKIVQDRIDLKSLIDEHIGKRKAIENEFNSDPKSFNDESLRERIQILEKIRANLLRIISMKSEAYYRLLNKADNVRRDEISKYVEIENRKNKERENDILAENLKDFSSNVKDLVDRINQYKEDYEKKNKTILQDP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV98</accession>
    <name>Q5CV98_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">3 transmembrane region protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89742.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627371.1">
        <property type="nucleotide sequence ID" value="XM_627371.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV98"/>
    <dbReference type="GeneID" id="3374199"/>
    <dbReference type="KEGG" id="cpv:cgd8_4880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4880"/>
    <dbReference type="InParanoid" id="Q5CV98"/>
    <dbReference type="OMA" id="WAFYPIN"/>
    <dbReference type="OrthoDB" id="340245at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="112"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="160"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="215"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89742.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="392" mass="43850" checksum="BA03EF14D66A6D23" modified="2005-04-12" version="1">MFKRGVITANLANLVIAILLSGCAFGGVMLVQNWTMFDGVILSWELTPSQLYITLNCSSRSKRFLGFCVNGIKEIHGSFANVVQAICNPSEKYKFLTNSCEDAISLTNYLNIIYFVLLASASVSIFGVAFLMLYSRSFKVEDNKTNCKTSEVILKSKPRIGLAVVSILFSILALLGVSFCSVLVIYLSQSLQDILSFSSDVPIFTIEPFKGSLGWGFYLLLLANSLLIVHILALVDSTRMAKNLWLFSQEIMESNAAKQHSEIVIKNTNKVPEKFFVHSFPPSSIETQGLQNTGSTFLPNSGVVGSRIQVPITSEDQSHCQYMPLVQNQQLYPKISNTPSTRSVWGFFPVNLLPRFNPYNSGMPNFMNNYGDHHCHRHQGCNHHHHHHHHHN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVB1</accession>
    <name>Q5CVB1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">holo-[acyl-carrier-protein] synthase</fullName>
            <ecNumber evidence="1">2.7.8.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_4740</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.7" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89734.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627358.1">
        <property type="nucleotide sequence ID" value="XM_627358.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVB1"/>
    <dbReference type="STRING" id="353152.Q5CVB1"/>
    <dbReference type="GeneID" id="3374661"/>
    <dbReference type="KEGG" id="cpv:cgd8_4740"/>
    <dbReference type="InParanoid" id="Q5CVB1"/>
    <dbReference type="OMA" id="DFNVSHY"/>
    <dbReference type="OrthoDB" id="26719at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008897">
        <property type="term" value="F:holo-[acyl-carrier-protein] synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019878">
        <property type="term" value="P:lysine biosynthetic process via aminoadipic acid"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.470.20">
        <property type="entry name" value="4'-phosphopantetheinyl transferase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008278">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037143">
        <property type="entry name" value="4-PPantetheinyl_Trfase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055066">
        <property type="entry name" value="AASDHPPT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050559">
        <property type="entry name" value="P-Pant_transferase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215:SF10">
        <property type="entry name" value="L-AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12215">
        <property type="entry name" value="PHOSPHOPANTETHEINE TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22624">
        <property type="entry name" value="AASDHPPT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01648">
        <property type="entry name" value="ACPS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56214">
        <property type="entry name" value="4'-phosphopantetheinyl transferase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="4'-phosphopantetheinyl transferase N-terminal" evidence="4">
        <location>
            <begin position="2"/>
            <end position="70"/>
        </location>
    </feature>
    <feature type="domain" description="4'-phosphopantetheinyl transferase" evidence="3">
        <location>
            <begin position="76"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF22624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89734.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="267" mass="31545" checksum="A26C5295F901C684" modified="2005-04-12" version="1" fragment="single">IRYKILDDRKRSLLSVLLMKLALMNYYDISPKQVKIIREKGMKPYFKYDSESDSLLHFNVSHDGDVVVIILSKYMVGIDIMKTELSPSRVQLSNNIMEANEKFLNNMKNVFHPSEWEYIQKDISKFMHYWTIKESFVKYIGLGLYVDPRRLLIDSSLVKENHQCNLNSPYLKQSNIYLDNQLQVRKSILLNISIYILINATEYVKLIYCLIFRIVRSIHLTKLFPIIIFLSVYQKVILRNSTHTIFLAIKLSILMSLRDHNFVKILL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVB9</accession>
    <name>Q5CVB9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DNA polymerase delta subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89600.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627350.1">
        <property type="nucleotide sequence ID" value="XM_627350.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVB9"/>
    <dbReference type="STRING" id="353152.Q5CVB9"/>
    <dbReference type="GeneID" id="3374449"/>
    <dbReference type="KEGG" id="cpv:cgd8_4650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4650"/>
    <dbReference type="InParanoid" id="Q5CVB9"/>
    <dbReference type="OrthoDB" id="337486at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043625">
        <property type="term" value="C:delta DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000731">
        <property type="term" value="P:DNA synthesis involved in DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007218">
        <property type="entry name" value="DNA_pol_delta_4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14303:SF0">
        <property type="entry name" value="DNA POLYMERASE DELTA SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04081">
        <property type="entry name" value="DNA_pol_delta_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="24"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89600.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="128" mass="14476" checksum="C853119D93C0E902" modified="2005-04-12" version="1">MPPNVNKKRKRSAKGLKESEKENQSKLVGFKTSIVRPIVNPELEATDLKPVQSANDNEQLLNTLHSFDLDHTFGPCSEISRSKRLERAKKFGIAIDLNLEKMINKHCGDVNSEMSVSIIDKLMKHYAD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVJ1</accession>
    <name>Q5CVJ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_3860</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89540.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627278.1">
        <property type="nucleotide sequence ID" value="XM_627278.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVJ1"/>
    <dbReference type="GeneID" id="3374255"/>
    <dbReference type="KEGG" id="cpv:cgd8_3860"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3860"/>
    <dbReference type="InParanoid" id="Q5CVJ1"/>
    <dbReference type="OMA" id="NSTHICY"/>
    <dbReference type="OrthoDB" id="341778at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89540.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="696" mass="81652" checksum="4D2B0D5EFF50E74E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVJ7</accession>
    <name>Q5CVJ7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Apoptosis-antagonizing transcription factor C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89720.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627272.1">
        <property type="nucleotide sequence ID" value="XM_627272.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVJ7"/>
    <dbReference type="STRING" id="353152.Q5CVJ7"/>
    <dbReference type="GeneID" id="3374610"/>
    <dbReference type="KEGG" id="cpv:cgd8_3800"/>
    <dbReference type="InParanoid" id="Q5CVJ7"/>
    <dbReference type="OMA" id="EFVDCIM"/>
    <dbReference type="OrthoDB" id="5783963at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039223">
        <property type="entry name" value="AATF/Bfr2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012617">
        <property type="entry name" value="AATF_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565">
        <property type="entry name" value="AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15565:SF0">
        <property type="entry name" value="PROTEIN AATF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08164">
        <property type="entry name" value="TRAUB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Apoptosis-antagonizing transcription factor C-terminal" evidence="1">
        <location>
            <begin position="69"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF08164"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89720.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="157" mass="17717" checksum="046A891AFD171161" modified="2005-04-12" version="1" fragment="single">VQKNFKVLNQSLRVQLEQTLLNKEHALNKSRPNANSLNFIGIDFLRDKVDPMLMYELSKDIYDDSDSFVSLLKEIISSKSITDPNLNSVSSSLLSKGKKTVNNVDRRASKGRKIRYVPIPKLENFMASSPSLYSNSYLPGADNEEFVDCIMKSLLLA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVQ2</accession>
    <name>Q5CVQ2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">DNA 3'-5' helicase</fullName>
            <ecNumber evidence="7">5.6.2.4</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_3210</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>Couples ATP hydrolysis with the unwinding of duplex DNA by translocating in the 3'-5' direction.</text>
            <dbReference type="EC" id="5.6.2.4"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.4" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627217.1">
        <property type="nucleotide sequence ID" value="XM_627217.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVQ2"/>
    <dbReference type="FunCoup" id="Q5CVQ2">
        <property type="interactions" value="40"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVQ2"/>
    <dbReference type="GeneID" id="3374244"/>
    <dbReference type="KEGG" id="cpv:cgd8_3210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3210"/>
    <dbReference type="InParanoid" id="Q5CVQ2"/>
    <dbReference type="OMA" id="GHNKNED"/>
    <dbReference type="OrthoDB" id="417752at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043138">
        <property type="term" value="F:3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000725">
        <property type="term" value="P:recombinational repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17932">
        <property type="entry name" value="DEXQc_UvrD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.486.10">
        <property type="entry name" value="PCRA, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014017">
        <property type="entry name" value="DNA_helicase_UvrD-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000212">
        <property type="entry name" value="DNA_helicase_UvrD/REP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014016">
        <property type="entry name" value="UvrD-like_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070:SF2">
        <property type="entry name" value="ATP-DEPENDENT DNA HELICASE SRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11070">
        <property type="entry name" value="UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00580">
        <property type="entry name" value="UvrD-helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13361">
        <property type="entry name" value="UvrD_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51198">
        <property type="entry name" value="UVRD_HELICASE_ATP_BIND"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51217">
        <property type="entry name" value="UVRD_HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 9 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0413">Isomerase</keyword>
    <keyword evidence="1 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="UvrD-like helicase ATP-binding" evidence="10">
        <location>
            <begin position="33"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="domain" description="UvrD-like helicase C-terminal" evidence="11">
        <location>
            <begin position="422"/>
            <end position="815"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="54"/>
            <end position="61"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00034617"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00034808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048988"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51198"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51217"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="917" mass="106004" checksum="DFD4650F81410140" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVT2</accession>
    <name>Q5CVT2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L10A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_2870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89701.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627187.1">
        <property type="nucleotide sequence ID" value="XM_627187.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVT2"/>
    <dbReference type="FunCoup" id="Q5CVT2">
        <property type="interactions" value="329"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVT2"/>
    <dbReference type="GeneID" id="3374331"/>
    <dbReference type="KEGG" id="cpv:cgd8_2870"/>
    <dbReference type="InParanoid" id="Q5CVT2"/>
    <dbReference type="OMA" id="GPRNKMP"/>
    <dbReference type="OrthoDB" id="2449818at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015934">
        <property type="term" value="C:large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00403">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000006">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.790:FF:000002">
        <property type="entry name" value="Ribosomal protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.190.20:FF:000009">
        <property type="entry name" value="Ribosomal protein L10a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.190.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.790">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050257">
        <property type="entry name" value="eL8/uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002143">
        <property type="entry name" value="Ribosomal_uL1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023674">
        <property type="entry name" value="Ribosomal_uL1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028364">
        <property type="entry name" value="Ribosomal_uL1/biogenesis"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016095">
        <property type="entry name" value="Ribosomal_uL1_3-a/b-sand"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23105">
        <property type="entry name" value="RIBOSOMAL PROTEIN L7AE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00687">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002155">
        <property type="entry name" value="Ribosomal_L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56808">
        <property type="entry name" value="Ribosomal protein L1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89701.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="221" mass="24699" checksum="D6F7E219E58BDE64" modified="2005-04-12" version="1" fragment="single">LSAMSGKVSSETIRRAISEILEGSKAKPRKFVETVELQIGLKDYDTQRDKRFAGTVRLPNVPRPNARVCVMGDAADCERAQKLGFDVMDIEEMKKINKNKKVVKKLCKKYDLFLASQVLLPQIPRLLGPGLNKAGKFPTVITPSDKIDEKANELKASIKFQLKKVLCLGVAIGNVNMTEEEIRQNLTLAINFLVSLLKKNWHNIKSLTVKSTMGKSVRIYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVW6</accession>
    <name>Q5CVW6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Sushi-domain containing secreted protein with a signal peptide, low complexity region followed by a sushi domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_2530</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89442.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627153.1">
        <property type="nucleotide sequence ID" value="XM_627153.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVW6"/>
    <dbReference type="STRING" id="353152.Q5CVW6"/>
    <dbReference type="GeneID" id="3374571"/>
    <dbReference type="KEGG" id="cpv:cgd8_2530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2530"/>
    <dbReference type="InParanoid" id="Q5CVW6"/>
    <dbReference type="OMA" id="KEIAHYW"/>
    <dbReference type="OrthoDB" id="344044at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00033">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.10.70.10">
        <property type="entry name" value="Complement Module, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044574">
        <property type="entry name" value="ARIP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035976">
        <property type="entry name" value="Sushi/SCR/CCP_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000436">
        <property type="entry name" value="Sushi_SCR_CCP_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797:SF1">
        <property type="entry name" value="HELICASE ARIP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45797">
        <property type="entry name" value="RAD54-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00084">
        <property type="entry name" value="Sushi"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00032">
        <property type="entry name" value="CCP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57535">
        <property type="entry name" value="Complement control module/SCR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="6" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0347">Helicase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="10">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254477" evidence="10">
        <location>
            <begin position="28"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="domain" description="Sushi" evidence="11">
        <location>
            <begin position="773"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="34"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="871"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="9">
        <location>
            <begin position="34"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="53"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="77"/>
            <end position="221"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="230"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="288"/>
            <end position="304"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="308"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="333"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="367"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="420"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="454"/>
            <end position="496"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="889"/>
            <end position="908"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="912"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="928"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89442.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1006" mass="113388" checksum="DF7E7A07274C3C94" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVZ8</accession>
    <name>Q5CVZ8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_2180</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627121.1">
        <property type="nucleotide sequence ID" value="XM_627121.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVZ8"/>
    <dbReference type="STRING" id="353152.Q5CVZ8"/>
    <dbReference type="GeneID" id="3374560"/>
    <dbReference type="KEGG" id="cpv:cgd8_2180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2180"/>
    <dbReference type="InParanoid" id="Q5CVZ8"/>
    <dbReference type="OMA" id="IDENIHM"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF3">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE NEK1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0418">Kinase</keyword>
    <keyword evidence="4 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="11">
        <location>
            <begin position="4"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="457"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="463"/>
            <end position="493"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="36"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="533" mass="62242" checksum="9B751EDC5DA20C39" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW22</accession>
    <name>Q5CW22_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Large protein with a GCN1 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_1930</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627097.1">
        <property type="nucleotide sequence ID" value="XM_627097.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW22"/>
    <dbReference type="GeneID" id="3374469"/>
    <dbReference type="KEGG" id="cpv:cgd8_1930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1930"/>
    <dbReference type="InParanoid" id="Q5CW22"/>
    <dbReference type="OMA" id="DGTINTH"/>
    <dbReference type="OrthoDB" id="5148094at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019887">
        <property type="term" value="F:protein kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021133">
        <property type="entry name" value="HEAT_type_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346:SF7">
        <property type="entry name" value="STALLED RIBOSOME SENSOR GCN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23346">
        <property type="entry name" value="TRANSLATIONAL ACTIVATOR GCN1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24984">
        <property type="entry name" value="HEAT_EF3_GNC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24987">
        <property type="entry name" value="HEAT_EF3_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50077">
        <property type="entry name" value="HEAT_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="HEAT" evidence="2">
        <location>
            <begin position="2243"/>
            <end position="2278"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="998"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1047"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2182"/>
            <end position="2201"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="3">
        <location>
            <begin position="3096"/>
            <end position="3123"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="1010"/>
            <end position="1033"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="1062"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="3395" mass="384294" checksum="7B8F7384D5A60DF9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW66</accession>
    <name>Q5CW66_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sex-lethal interacting like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1460</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89358.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627053.1">
        <property type="nucleotide sequence ID" value="XM_627053.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW66"/>
    <dbReference type="STRING" id="353152.Q5CW66"/>
    <dbReference type="GeneID" id="3374582"/>
    <dbReference type="KEGG" id="cpv:cgd8_1460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1460"/>
    <dbReference type="InParanoid" id="Q5CW66"/>
    <dbReference type="OMA" id="NISHAQY"/>
    <dbReference type="OrthoDB" id="340681at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042797">
        <property type="term" value="P:tRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006886">
        <property type="entry name" value="RNA_pol_III_Rpc5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069:SF0">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12069">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES III 80 KDA POLYPEPTIDE RNA POLYMERASE III SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04801">
        <property type="entry name" value="RPC5"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="65"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="65"/>
            <end position="84"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89358.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="895" mass="101372" checksum="3C00C6BAE2FF2655" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW88</accession>
    <name>Q5CW88_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-directed DNA polymerase</fullName>
            <ecNumber evidence="3">2.7.7.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd8_1240</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase type-B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.7" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627031.1">
        <property type="nucleotide sequence ID" value="XM_627031.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CW88">
        <property type="interactions" value="119"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW88"/>
    <dbReference type="GeneID" id="3374264"/>
    <dbReference type="KEGG" id="cpv:cgd8_1240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1240"/>
    <dbReference type="InParanoid" id="Q5CW88"/>
    <dbReference type="OMA" id="NCENEET"/>
    <dbReference type="OrthoDB" id="10060449at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008622">
        <property type="term" value="C:epsilon DNA polymerase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003887">
        <property type="term" value="F:DNA-directed DNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000166">
        <property type="term" value="F:nucleotide binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008310">
        <property type="term" value="F:single-stranded DNA 3'-5' DNA exonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006287">
        <property type="term" value="P:base-excision repair, gap-filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045004">
        <property type="term" value="P:DNA replication proofreading"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000278">
        <property type="term" value="P:mitotic cell cycle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006297">
        <property type="term" value="P:nucleotide-excision repair, DNA gap filling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05779">
        <property type="entry name" value="DNA_polB_epsilon_exo"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd05535">
        <property type="entry name" value="POLBc_epsilon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.10:FF:000010">
        <property type="entry name" value="DNA polymerase epsilon catalytic subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.60">
        <property type="entry name" value="DNA polymerase family B, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.342.10">
        <property type="entry name" value="DNA Polymerase, chain B, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.690">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1600.10">
        <property type="entry name" value="Palm domain of DNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.10">
        <property type="entry name" value="Ribonuclease H-like superfamily/Ribonuclease H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006172">
        <property type="entry name" value="DNA-dir_DNA_pol_B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006133">
        <property type="entry name" value="DNA-dir_DNA_pol_B_exonuc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006134">
        <property type="entry name" value="DNA-dir_DNA_pol_B_multi_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043502">
        <property type="entry name" value="DNA/RNA_pol_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042087">
        <property type="entry name" value="DNA_pol_B_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013697">
        <property type="entry name" value="DNA_pol_e_suA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023211">
        <property type="entry name" value="DNA_pol_palm_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029703">
        <property type="entry name" value="POL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055191">
        <property type="entry name" value="POL2_thumb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012337">
        <property type="entry name" value="RNaseH-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036397">
        <property type="entry name" value="RNaseH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054475">
        <property type="entry name" value="Znf-DPOE"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10670:SF0">
        <property type="entry name" value="DNA POLYMERASE EPSILON CATALYTIC SUBUNIT A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00136">
        <property type="entry name" value="DNA_pol_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03104">
        <property type="entry name" value="DNA_pol_B_exo1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08490">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22634">
        <property type="entry name" value="POL2_thumb"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22912">
        <property type="entry name" value="zf-DPOE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23250">
        <property type="entry name" value="zf_DPOE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01159">
        <property type="entry name" value="DUF1744"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00486">
        <property type="entry name" value="POLBc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56672">
        <property type="entry name" value="DNA/RNA polymerases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53098">
        <property type="entry name" value="Ribonuclease H-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="14" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="11" id="KW-0239">DNA-directed DNA polymerase</keyword>
    <keyword evidence="12" id="KW-0408">Iron</keyword>
    <keyword evidence="13" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="8" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="15" id="KW-0539">Nucleus</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <keyword evidence="10" id="KW-0862">Zinc</keyword>
    <keyword evidence="9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="DNA polymerase epsilon catalytic subunit A C-terminal" evidence="17">
        <location>
            <begin position="1711"/>
            <end position="2270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1297"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="1340"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2094"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="16">
        <location>
            <begin position="2400"/>
            <end position="2423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="16">
        <location>
            <begin position="1302"/>
            <end position="1317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="16">
        <location>
            <begin position="2102"/>
            <end position="2121"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="2122"/>
            <end position="2142"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="16">
        <location>
            <begin position="2402"/>
            <end position="2414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005755"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012417"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022932"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01159"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAK89342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2728" mass="318313" checksum="2A614B0A5E8B2FB2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWC1</accession>
    <name>Q5CWC1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ydr449cp/Utp6p small (Ribosomal) subunit (SSU) processosome (Contains U3 snoRNA). HAT repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_900</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89317.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626998.1">
        <property type="nucleotide sequence ID" value="XM_626998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWC1"/>
    <dbReference type="STRING" id="353152.Q5CWC1"/>
    <dbReference type="GeneID" id="3374418"/>
    <dbReference type="KEGG" id="cpv:cgd8_900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_900"/>
    <dbReference type="InParanoid" id="Q5CWC1"/>
    <dbReference type="OrthoDB" id="28112at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000462">
        <property type="term" value="P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013949">
        <property type="entry name" value="Utp6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055347">
        <property type="entry name" value="UTP6_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271">
        <property type="entry name" value="HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23271:SF1">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08640">
        <property type="entry name" value="U3_assoc_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0698">rRNA processing</keyword>
    <feature type="domain" description="U3 small nucleolar RNA-associated protein 6 N-terminal" evidence="5">
        <location>
            <begin position="9"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF08640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89317.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="970" mass="113327" checksum="5D7415245601643A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWH1</accession>
    <name>Q5CWH1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_5110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90084.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627833.1">
        <property type="nucleotide sequence ID" value="XM_627833.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CWH1"/>
    <dbReference type="GeneID" id="3375829"/>
    <dbReference type="KEGG" id="cpv:cgd6_5110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5110"/>
    <dbReference type="InParanoid" id="Q5CWH1"/>
    <dbReference type="OMA" id="VDVMNEM"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2264"/>
            <end position="2329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2369"/>
            <end position="2409"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2274"/>
            <end position="2317"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2374"/>
            <end position="2395"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90084.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2711" mass="322641" checksum="C5D202C5C30093C5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWR5</accession>
    <name>Q5CWR5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Putative apicomplexan-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_4050</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90008.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627739.1">
        <property type="nucleotide sequence ID" value="XM_627739.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWR5"/>
    <dbReference type="FunCoup" id="Q5CWR5">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="3375753"/>
    <dbReference type="KEGG" id="cpv:cgd6_4050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4050"/>
    <dbReference type="InParanoid" id="Q5CWR5"/>
    <dbReference type="OMA" id="FWANQEI"/>
    <dbReference type="OrthoDB" id="365277at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.270.50">
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90008.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="800" mass="91978" checksum="7BE6F6309C08C01D" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="32" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWR9</accession>
    <name>Q5CWR9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90005.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627735.1">
        <property type="nucleotide sequence ID" value="XM_627735.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWR9"/>
    <dbReference type="GeneID" id="3375750"/>
    <dbReference type="KEGG" id="cpv:cgd6_4000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4000"/>
    <dbReference type="InParanoid" id="Q5CWR9"/>
    <dbReference type="OMA" id="ISIHYLH"/>
    <dbReference type="OrthoDB" id="343911at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254323" evidence="1">
        <location>
            <begin position="29"/>
            <end position="645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90005.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="645" mass="75380" checksum="22CA209FB8133C41" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWX7</accession>
    <name>Q5CWX7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_3320</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89957.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627677.1">
        <property type="nucleotide sequence ID" value="XM_627677.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWX7"/>
    <dbReference type="GeneID" id="3375702"/>
    <dbReference type="KEGG" id="cpv:cgd6_3320"/>
    <dbReference type="InParanoid" id="Q5CWX7"/>
    <dbReference type="OrthoDB" id="336240at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036339">
        <property type="entry name" value="PUB-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143503">
        <property type="entry name" value="PUG domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89957.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="106" mass="12524" checksum="A69033A14E914858" modified="2005-04-12" version="1">MNNENFFKSFGDKKGSFAIFYGIGFRIIQSEERKEYFEILSSDKDLGINVSRLNSNDEYLILREPDPIDQFEIWVTWMEKLSLINDILVSFMNIEIGIEYPHFKGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX03</accession>
    <name>Q5CX03_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_3050</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89935.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627651.1">
        <property type="nucleotide sequence ID" value="XM_627651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX03"/>
    <dbReference type="STRING" id="353152.Q5CX03"/>
    <dbReference type="GeneID" id="3375680"/>
    <dbReference type="KEGG" id="cpv:cgd6_3050"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3050"/>
    <dbReference type="InParanoid" id="Q5CX03"/>
    <dbReference type="OrthoDB" id="344344at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="662"/>
            <end position="683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="765"/>
            <end position="787"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="840"/>
            <end position="881"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="726"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="632"/>
            <end position="642"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="766"/>
            <end position="779"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="867"/>
            <end position="879"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89935.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1012" mass="111472" checksum="BF162972BF743BE1" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX96</accession>
    <name>Q5CX96_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_1970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89857.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627558.1">
        <property type="nucleotide sequence ID" value="XM_627558.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3376069"/>
    <dbReference type="KEGG" id="cpv:cgd6_1970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1970"/>
    <dbReference type="InParanoid" id="Q5CX96"/>
    <dbReference type="OMA" id="CYMNKLL"/>
    <dbReference type="OrthoDB" id="340149at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89857.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2333" mass="275355" checksum="3EC744329C1FB2D9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXA3</accession>
    <name>Q5CXA3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Signal recognition particle SPR19</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_1870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90132.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627551.1">
        <property type="nucleotide sequence ID" value="XM_627551.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXA3"/>
    <dbReference type="FunCoup" id="Q5CXA3">
        <property type="interactions" value="297"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXA3"/>
    <dbReference type="GeneID" id="3375877"/>
    <dbReference type="KEGG" id="cpv:cgd6_1870"/>
    <dbReference type="InParanoid" id="Q5CXA3"/>
    <dbReference type="OMA" id="QMERWIC"/>
    <dbReference type="OrthoDB" id="2190947at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005786">
        <property type="term" value="C:signal recognition particle, endoplasmic reticulum targeting"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008312">
        <property type="term" value="F:7S RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006617">
        <property type="term" value="P:SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.56.30">
        <property type="entry name" value="Signal recognition particle, SRP19-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002778">
        <property type="entry name" value="Signal_recog_particle_SRP19"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036521">
        <property type="entry name" value="SRP19-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KD PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17453:SF0">
        <property type="entry name" value="SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01922">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69695">
        <property type="entry name" value="SRP19"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3" id="KW-0733">Signal recognition particle</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90132.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="174" mass="19774" checksum="00CD3651AB9B9FD3" modified="2005-04-12" version="1" fragment="single">FVNKMNKERTQADQDTSKWKIIYPSYLNSNNTKSSGRLSSLIHCVEDPTIAEIAEVCIQLGIPCKVESKRYSKDCRTLGRVRFQLFDESGRAFNDRILTKKILLNQIGIMIPKLKNRQNTTSSVIDHANSRNNKANIDDIHNENNCKIKETDSITYSGVNIHSSNAKSNSKKKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXF1</accession>
    <name>Q5CXF1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1320</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89813.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627503.1">
        <property type="nucleotide sequence ID" value="XM_627503.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXF1"/>
    <dbReference type="GeneID" id="3376006"/>
    <dbReference type="KEGG" id="cpv:cgd6_1320"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1320"/>
    <dbReference type="InParanoid" id="Q5CXF1"/>
    <dbReference type="OMA" id="CNTRTIP"/>
    <dbReference type="OrthoDB" id="339651at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="6"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="49"/>
            <end position="74"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89813.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="252" mass="29049" checksum="90499D65B2E16293" modified="2007-04-03" version="1">MALKTNISIAISDFIWNTYYDLISSIFYGKKYRPKSPRPKFTVNKVLKLVLWLLGWLSVTFIIPLCGIILAYSISPSRVDIVPAVFEKNYLVISQPLLRTNSQSSVVNFTTSISFLFDIKYVNRLFVDKIMIEGVEIAYIGRIPVDSNNKSSCNSDNLDYLFPDFTKFKYKKIPDEMIDFTCTKDYRNCTVSINIQSFFIDSYDEYSYNHDSGFGYSNFVIRTSFTSSQFISTLVSGRLGYRYNPLSIPIKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXK7</accession>
    <name>Q5CXK7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Ribonucleotide reductase small subunit, duplicated adjacent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ribonucleoside diphosphate reductase small chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89769.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627447.1">
        <property type="nucleotide sequence ID" value="XM_627447.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXK7"/>
    <dbReference type="FunCoup" id="Q5CXK7">
        <property type="interactions" value="42"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXK7"/>
    <dbReference type="GeneID" id="3376059"/>
    <dbReference type="KEGG" id="cpv:cgd6_690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_690"/>
    <dbReference type="InParanoid" id="Q5CXK7"/>
    <dbReference type="OMA" id="LEPMFLG"/>
    <dbReference type="OrthoDB" id="10248373at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016491">
        <property type="term" value="F:oxidoreductase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009263">
        <property type="term" value="P:deoxyribonucleotide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01049">
        <property type="entry name" value="RNRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.620.20">
        <property type="entry name" value="Ribonucleotide Reductase, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009078">
        <property type="entry name" value="Ferritin-like_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012348">
        <property type="entry name" value="RNR-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033909">
        <property type="entry name" value="RNR_small"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030475">
        <property type="entry name" value="RNR_small_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000358">
        <property type="entry name" value="RNR_small_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23409:SF18">
        <property type="entry name" value="RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SUBUNIT M2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00268">
        <property type="entry name" value="Ribonuc_red_sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47240">
        <property type="entry name" value="Ferritin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00368">
        <property type="entry name" value="RIBORED_SMALL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="188"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009303"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89769.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="352" mass="41203" checksum="AB04BF5BDC81F308" modified="2007-04-03" version="1">MTEENNNVILTKETKDEENIEKLVNEVKINQVNEPMLKYSRENRNELKELIKDIWSMYKKAEASFWVTEEIDLSQDTRDWESLKDPERHFIKYVLAFFAASDGIVMENLAVNFLREIQIPEARMYYAFQMSIEQIHSETYSLLIDRYITEIKERQMLFEAISHIEAVKKKAEWATKWMNSERSFAERIIGFCAVEGILFSGSFCAIFWLKKRGLMPGLTFSNELISRDEGLHADFACLIYKALKFKLPAPRVQQIISEAVEVERNFLCDSLPVDLIGMNSRLMAQYIEFVADRLLFALDIPKIYNVSNPFDWMDLISLQGKTNFFEKRVGEYQMAGVMVNQDDQKFDLNADF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXK8</accession>
    <name>Q5CXK8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Conserved protein with possible C2 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89764.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627446.1">
        <property type="nucleotide sequence ID" value="XM_627446.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXK8"/>
    <dbReference type="GeneID" id="3376054"/>
    <dbReference type="KEGG" id="cpv:cgd6_680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_680"/>
    <dbReference type="InParanoid" id="Q5CXK8"/>
    <dbReference type="OMA" id="HNSQFHA"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="CDD" id="cd00030">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000008">
        <property type="entry name" value="C2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052299">
        <property type="entry name" value="CEP76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436:SF2">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_119, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00168">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00239">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49562">
        <property type="entry name" value="C2 domain (Calcium/lipid-binding domain, CaLB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50004">
        <property type="entry name" value="C2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2" evidence="2">
        <location>
            <begin position="544"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="18"/>
            <end position="107"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="352"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1275"/>
            <end position="1349"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1563"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1609"/>
            <end position="1665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="53"/>
            <end position="63"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="76"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1568"/>
            <end position="1597"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1609"/>
            <end position="1645"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89764.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1665" mass="193658" checksum="FC373ACE7C3000BA" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXM9</accession>
    <name>Q5CXM9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="3" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="3">Iowa type II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89747.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627425.1">
        <property type="nucleotide sequence ID" value="XM_627425.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXM9"/>
    <dbReference type="GeneID" id="3376104"/>
    <dbReference type="KEGG" id="cpv:cgd6_420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_420"/>
    <dbReference type="InParanoid" id="Q5CXM9"/>
    <dbReference type="OMA" id="GYLYMSL"/>
    <dbReference type="OrthoDB" id="343555at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254522" evidence="2">
        <location>
            <begin position="21"/>
            <end position="377"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="151"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="179"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="231"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="288"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="329"/>
            <end position="349"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89747.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="377" mass="43463" checksum="196B12D03A46AD5C" modified="2005-04-12" version="1">MKIKIFFLIQILLLIAYVKGDIRRNELNRNNEYILLNNNAPQVPIVTETKTPIRYPRFPAQKMRTNHSKLEELSKKYLNPMMRIPELNYQYLSLTMSRFMTVMLSLLVVPFITLSLFGDTGDLIFAQFGCISGVFGFTMGMMIFGGLISDIMAIIFSTIIGFANIYSTLKLTKVREMPFVSILFFCFLVSNLIYQLLAGIPNYSINPLYTGLGGALLMRISNIFGYQFQNLTLFVMALKLFYIIIVICITSIIYFILPSSLKKVAGNEKQTDEEISNLQKYTQSISSFILTFPIVSFISQMLYVLGIFTTSPFDMLSFFYIPSQLHFNYYSTSILLTVWIFLTVSVFLFRTKISNRDSYQPKFVKSLISDYWKVQEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXR5</accession>
    <name>Q5CXR5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Splicing factor with 3 RRM domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_5220</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90478.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_628663.1"/>
    </dbReference>
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    <dbReference type="STRING" id="353152.Q5CXR5"/>
    <dbReference type="GeneID" id="3372096"/>
    <dbReference type="KEGG" id="cpv:cgd7_5220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5220"/>
    <dbReference type="InParanoid" id="Q5CXR5"/>
    <dbReference type="OMA" id="GRDNDKG"/>
    <dbReference type="OrthoDB" id="5411533at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
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        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
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        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12283">
        <property type="entry name" value="RRM1_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd12285">
        <property type="entry name" value="RRM3_RBM39_like"/>
        <property type="match status" value="1"/>
    </dbReference>
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        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006509">
        <property type="entry name" value="RBM39_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003954">
        <property type="entry name" value="RRM_euk-type"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01622">
        <property type="entry name" value="SF-CC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48036">
        <property type="entry name" value="SPLICING FACTOR (PAD-1), PUTATIVE (AFU_ORTHOLOGUE AFUA_1G15810)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00361">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="134"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="233"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="462"/>
            <end position="554"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="336"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="392"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="49"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="88"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="336"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="403"/>
            <end position="430"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90478.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="563" mass="64321" checksum="FD3087442DF832CD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXY5</accession>
    <name>Q5CXY5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Family 2 glycosyl transferase, possible</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4440</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90420.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628595.1">
        <property type="nucleotide sequence ID" value="XM_628593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXY5"/>
    <dbReference type="GeneID" id="3372174"/>
    <dbReference type="KEGG" id="cpv:cgd7_4440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4440"/>
    <dbReference type="InParanoid" id="Q5CXY5"/>
    <dbReference type="OMA" id="INHYAND"/>
    <dbReference type="OrthoDB" id="339681at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00761">
        <property type="entry name" value="Glyco_tranf_GTA_type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="1">
        <location>
            <begin position="40"/>
            <end position="162"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90420.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="292" mass="33979" checksum="DBE55164C7FB0095" modified="2005-04-12" version="1">MELVEKEVEAVGQVPMDHFDPDISVVIPVAFDDLRSFPVLLSVLRLQTLRPEEIIIVFDFPEHEVEARAKAMEEVKKYSSSLRNLRPFFRIPPPPPNHRAGSNRLYGASKAKNEIIIFFDSDDLMHPQRVEYVSRAFKANKDMDAFLTEYFVEQMDTTEQAKEMPSKSMIDIKTKFDLDQIEREGKLLRNSYEEEFKEAEKAVKEYGLKCPWDPNDKLTEINWPETHGWWLYCCHNGWLTIKRSVLIEVPYPDKPSGEDSLYVFRLLMSRKNVGHSTVPLGVYVLGNTYEVR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY55</accession>
    <name>Q5CY55_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">PP2C phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90357.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628525.1">
        <property type="nucleotide sequence ID" value="XM_628523.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY55"/>
    <dbReference type="STRING" id="353152.Q5CY55"/>
    <dbReference type="GeneID" id="3372112"/>
    <dbReference type="KEGG" id="cpv:cgd7_3620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3620"/>
    <dbReference type="InParanoid" id="Q5CY55"/>
    <dbReference type="OMA" id="IYFGWHK"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47992">
        <property type="entry name" value="PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="1">
        <location>
            <begin position="124"/>
            <end position="442"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90357.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="452" mass="51417" checksum="74464F7128052D61" modified="2005-04-12" version="1">MKDNNDRTIEAYQGTLKHDKLNANLSNMNGTPLLVHEELNDFNYKLDEEHGWYVGDNSVWLYNKDNDVYYSSSLSKLFRLDQEKLRLIEMSTNFELEEVSNKEINIAHVEDECTPFLERGIHAGTSVIPSPTKNLDLCEDRHITKKQFFFNFNNQTPSTFFFSALFDGHAGNNCVEYVHQRLLTNIYTVFSQNMSRFSDKRSLCRAENSVCRVDNTRIFSSYIVESLCKGIKKGFEITNNSFLSIARKNKVFDGTTALVCIIFGPDPIDNKLKLVIGNCGDSKLILGYKSGNNSISAKRLTRIHRLSDINERTRIEKAGGKVEFCNGAWRVLVKKQQRYSFDVSAKCIGLCTSRSIGDINMKEPQLLCISDPEITVHEIDLENDLFLILATDGITDFFTDEELVGITEKNLKCTPTEAANELTKEAEKKGSLDDKTATVIYFQWSISELLNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY92</accession>
    <name>Q5CY92_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">SLBP family of RNA binding proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_3230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the SLBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628488.1">
        <property type="nucleotide sequence ID" value="XM_628486.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY92"/>
    <dbReference type="STRING" id="353152.Q5CY92"/>
    <dbReference type="GeneID" id="3372299"/>
    <dbReference type="KEGG" id="cpv:cgd7_3230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3230"/>
    <dbReference type="InParanoid" id="Q5CY92"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071204">
        <property type="term" value="C:histone pre-mRNA 3'end processing complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071207">
        <property type="term" value="F:histone pre-mRNA stem-loop binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006398">
        <property type="term" value="P:mRNA 3'-end processing by stem-loop binding and cleavage"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051028">
        <property type="term" value="P:mRNA transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.1120">
        <property type="entry name" value="Histone RNA hairpin-binding protein RNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026502">
        <property type="entry name" value="SLBP1/SLBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029344">
        <property type="entry name" value="SLBP_RNA_bind"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038294">
        <property type="entry name" value="SLBP_RNA_bind_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17408:SF0">
        <property type="entry name" value="HISTONE RNA HAIRPIN-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15247">
        <property type="entry name" value="SLBP_RNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Histone RNA hairpin-binding protein RNA-binding" evidence="3">
        <location>
            <begin position="140"/>
            <end position="204"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF15247"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="237" mass="27464" checksum="6D410E72E8D637AE" modified="2005-04-12" version="1">MINLDNNTPLFCNPMTPHRVYEVSILLLIGKKVKEKNFVSAIEVHPNLPKLEVKESEAKNLNSGSKYIQSKNSLFTLDSKNFDIYNEVDPPPNKGFFSFSDLTSLLEKLPSTELIKYGNYKSDFVRQNTELKASEEPLTSRMISRLKQIAIGKSLPEYKNYINQVPLEKRSSEDPRTPKCDTRLTKREFDNLYREWRVKLHQYESKFSSGASTRVNTPEDDLNHHSRYCPDIKTLKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYC8</accession>
    <name>Q5CYC8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Cathepsin like thiol protease possibly membrane associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_2850</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the peptidase C1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90297.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628452.1">
        <property type="nucleotide sequence ID" value="XM_628450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYC8"/>
    <dbReference type="STRING" id="353152.Q5CYC8"/>
    <dbReference type="GeneID" id="3372270"/>
    <dbReference type="KEGG" id="cpv:cgd7_2850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2850"/>
    <dbReference type="InParanoid" id="Q5CYC8"/>
    <dbReference type="OrthoDB" id="190265at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008234">
        <property type="term" value="F:cysteine-type peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd02248">
        <property type="entry name" value="Peptidase_C1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.70.10">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038765">
        <property type="entry name" value="Papain-like_cys_pep_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013128">
        <property type="entry name" value="Peptidase_C1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000668">
        <property type="entry name" value="Peptidase_C1A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039417">
        <property type="entry name" value="Peptidase_C1A_papain-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12411">
        <property type="entry name" value="CYSTEINE PROTEASE FAMILY C1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00112">
        <property type="entry name" value="Peptidase_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00705">
        <property type="entry name" value="PAPAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00645">
        <property type="entry name" value="Pept_C1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54001">
        <property type="entry name" value="Cysteine proteinases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0645">Protease</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0865">Zymogen</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase C1A papain C-terminal" evidence="5">
        <location>
            <begin position="389"/>
            <end position="617"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008455"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023145"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90297.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="673" mass="75273" checksum="E9180D46E78B7B99" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYD7</accession>
    <name>Q5CYD7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">WD40 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_2740</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90625.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628443.1">
        <property type="nucleotide sequence ID" value="XM_628441.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYD7"/>
    <dbReference type="STRING" id="353152.Q5CYD7"/>
    <dbReference type="GeneID" id="3371973"/>
    <dbReference type="KEGG" id="cpv:cgd7_2740"/>
    <dbReference type="InParanoid" id="Q5CYD7"/>
    <dbReference type="OMA" id="WNCVETI"/>
    <dbReference type="OrthoDB" id="339366at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031080">
        <property type="term" value="C:nuclear pore outer ring"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037363">
        <property type="entry name" value="Sec13/Seh1_fam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11024">
        <property type="entry name" value="NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0813">Transport</keyword>
    <keyword evidence="2" id="KW-0853">WD repeat</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90625.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="311" mass="35408" checksum="B9C53A87EABF521F" modified="2005-04-12" version="1" fragment="single">LLHISVGDRLVTADIKQNFHIFDLLPTCSNYDYLFRLIWVETSTLYDSSIVGTISRISWAPECFGQLFVAGTTQKNISIWSETRKGYQDTYHIIRNNFVFENGLGFKNGTFFDINNGSSWKLTTAFSPFKGKISNIKFADKDHGLIFAACDSNGIVGIFKCNDMAMKAEWELETLKVRKTDHFVDLGIANMEKHYTCCLDWIPYHVSSGIGITVAISNHIYIFKKKSIFWNCVETIAVNNAGIIKDISWSKLALFSDFYKLASLHEDNTLIIWKSTDSPNINELGRNKTISQLNKFESIGSIVSFAFFFFH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYD9</accession>
    <name>Q5CYD9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Ataxin2 related nudix domain protein (RNA processing phosphatase/ATpase domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd7_2710</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the Nudix hydrolase family. DCP2 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90287.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628441.1">
        <property type="nucleotide sequence ID" value="XM_628439.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYD9"/>
    <dbReference type="STRING" id="353152.Q5CYD9"/>
    <dbReference type="GeneID" id="3371935"/>
    <dbReference type="KEGG" id="cpv:cgd7_2710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2710"/>
    <dbReference type="InParanoid" id="Q5CYD9"/>
    <dbReference type="OMA" id="EAICDCY"/>
    <dbReference type="OrthoDB" id="18996at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140933">
        <property type="term" value="F:5'-(N(7)-methylguanosine 5'-triphospho)-[mRNA] hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030145">
        <property type="term" value="F:manganese ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000184">
        <property type="term" value="P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03672">
        <property type="entry name" value="NUDIX_Dcp2p_Nudt20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.79.10:FF:000003">
        <property type="entry name" value="M7GpppN-mRNA hydrolase isoform 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.1050">
        <property type="entry name" value="Dcp2, box A domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.79.10">
        <property type="entry name" value="Nucleoside Triphosphate Pyrophosphohydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007722">
        <property type="entry name" value="DCP2_BoxA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036189">
        <property type="entry name" value="DCP2_BoxA_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044099">
        <property type="entry name" value="Dcp2_NUDIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015797">
        <property type="entry name" value="NUDIX_hydrolase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020084">
        <property type="entry name" value="NUDIX_hydrolase_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000086">
        <property type="entry name" value="NUDIX_hydrolase_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23114:SF17">
        <property type="entry name" value="M7GPPPN-MRNA HYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05026">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00293">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01125">
        <property type="entry name" value="DCP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF140586">
        <property type="entry name" value="Dcp2 domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55811">
        <property type="entry name" value="Nudix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51462">
        <property type="entry name" value="NUDIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00893">
        <property type="entry name" value="NUDIX_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0464">Manganese</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Nudix hydrolase" evidence="10">
        <location>
            <begin position="320"/>
            <end position="451"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="576"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="579"/>
            <end position="589"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK90287.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="651" mass="74963" checksum="2AAB7E08569F93B2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYG6</accession>
    <name>Q5CYG6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Signal peptide, secreted low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_2410</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90262.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628414.1">
        <property type="nucleotide sequence ID" value="XM_628412.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYG6"/>
    <dbReference type="GeneID" id="3372211"/>
    <dbReference type="KEGG" id="cpv:cgd7_2410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2410"/>
    <dbReference type="InParanoid" id="Q5CYG6"/>
    <dbReference type="OMA" id="EPCIRIS"/>
    <dbReference type="OrthoDB" id="339612at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90262.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="412" mass="47535" checksum="0BB94AC36C066876" modified="2005-04-12" version="1">MKTLYLFHLRSIYILVLYQLILFNILNSSSQTLNKVTKSNENTEVLPTFDGCKNVLICERVDTRLFFNLELGICEKCKDRLLDVECSSIPTINNAYQLLSFTNGFDKEFHGANGYNKIVSMIERGATNESSILLSGKFVNLSGVEYCALDENNQIELFQEIYLIYNQNKNIENLTLDIKLINPFQAAENKTLEIISNWEINNKKSNHAMYAYKKIKEKMFDKKSESNSDINSQIFNNIFPSINVIFNSTNEQIFDNVKPCIRISCLKQKKKGSNNKIGEKNKVAVYDIVTSVNLLKSKVKSENDYLFYVNVLIKTLLKSLERKTKRKKISIGCTTKIISWVKELCEILGIQTDENSNMGRYISEFLKNTKKEPNFSKKTINVTNIVESKQNIGFIEAELEDYKKLEEELKEF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYJ5</accession>
    <name>Q5CYJ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Mitochondrial processing peptidase, insulinase like metalloprotease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_2080</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">Substrate recognition and binding subunit of the essential mitochondrial processing protease (MPP), which cleaves the mitochondrial sequence off newly imported precursors proteins.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90240.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628385.1">
        <property type="nucleotide sequence ID" value="XM_628383.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYJ5"/>
    <dbReference type="SMR" id="Q5CYJ5"/>
    <dbReference type="FunCoup" id="Q5CYJ5">
        <property type="interactions" value="466"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYJ5"/>
    <dbReference type="GeneID" id="3371888"/>
    <dbReference type="KEGG" id="cpv:cgd7_2080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2080"/>
    <dbReference type="InParanoid" id="Q5CYJ5"/>
    <dbReference type="OMA" id="SEMTHVA"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008237">
        <property type="term" value="F:metallopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF49">
        <property type="entry name" value="MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="5" id="KW-0645">Protease</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="3">
        <location>
            <begin position="60"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="4">
        <location>
            <begin position="216"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007261"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90240.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="497" mass="56245" checksum="D95CAD5B6A0B6633" modified="2005-04-12" version="1">MIQQKIRLFRHVLRNISTQVLRTKKPIFRQINGLRSIESYKIAPQNGIGPIFSELSNGMRVITLENSNKIASLGIIIKMGSRFESKSSFGSSRVLFNMILSQEGKTSQNCLPNKLALNGLMLAGGFNREYTSFLLEYLKDQGIENTQEFFDGIFKFYKKQFSDEELELAKKNIKEELLFELENPSIMLNELLHSTAWKENSLGNNQSTSFDQVSDLNIQNLTDFRNSNFLSRNTIIVGTGISHDHLIKKILNSSRKFDITEQNSVNNLKNDEQTMKIPKYVGGLVKNKLPHYGFTDILIAFETNLNWKGRELVALSVLQAYLGGGSSFSVGGPGKGIHSKLFLDVLNKFDWVESCNCFVNQYSDTGLFGIHITSYPGYSLESIKVIAKQLGKMKNISERELERAKNLVLSTICTAYENRSHYMEEISKQILSYSEFIELDEIINCIKSIGIEDIKKVADLILSKADRPTVVAVGTDMNQVPNYNEIISIISRQVSNY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYK4</accession>
    <name>Q5CYK4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_1990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90234.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628376.1">
        <property type="nucleotide sequence ID" value="XM_628374.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYK4"/>
    <dbReference type="GeneID" id="3371882"/>
    <dbReference type="KEGG" id="cpv:cgd7_1990"/>
    <dbReference type="InParanoid" id="Q5CYK4"/>
    <dbReference type="OrthoDB" id="342477at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="94"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="96"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90234.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="117" mass="13366" checksum="6901767C64D90808" modified="2005-04-12" version="1">MAKWLPGSSLSMSCVGLREKIEPERLKSLGSKEPEYSYETVRSGLVQLIKSNQSKFEIPYLEADGISSPQIQILPPSIKTLVVNPKIEYPKCMRRSEKRKLRKERRSTRKVVETSAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYL4</accession>
    <name>Q5CYL4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">KH domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_1890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628366.1">
        <property type="nucleotide sequence ID" value="XM_628364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYL4"/>
    <dbReference type="FunCoup" id="Q5CYL4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="3371748"/>
    <dbReference type="KEGG" id="cpv:cgd7_1890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1890"/>
    <dbReference type="InParanoid" id="Q5CYL4"/>
    <dbReference type="OMA" id="CAYELND"/>
    <dbReference type="OrthoDB" id="752362at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="333"/>
            <end position="397"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="399"/>
            <end position="481"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="3">
        <location>
            <begin position="707"/>
            <end position="773"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="91"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="28"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="818" mass="91252" checksum="A82D36EEEEC32884" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYY4</accession>
    <name>Q5CYY4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_550</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90539.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628246.1">
        <property type="nucleotide sequence ID" value="XM_628244.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYY4"/>
    <dbReference type="FunCoup" id="Q5CYY4">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYY4"/>
    <dbReference type="GeneID" id="3371914"/>
    <dbReference type="KEGG" id="cpv:cgd7_550"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_550"/>
    <dbReference type="InParanoid" id="Q5CYY4"/>
    <dbReference type="OMA" id="VGCGEEY"/>
    <dbReference type="OrthoDB" id="363842at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="47"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="112"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="139"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="161"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="200"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="346"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="366"/>
            <end position="378"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90539.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="402" mass="45067" checksum="4FED3E6BF76DBF33" modified="2005-04-12" version="1">MDNQHSETLLGTLREKYENSAILSLSSLFIFITLCNMFIMYRLLLDVIPYPIGVTFSQLLVGMMLAYVLGGCDLRKVKDETLSRFSEYAVPVGVYLLMFTIANILLKSTPVIAVYPCILALAVVLHHIFRYLFCDQRNLLSFKTVLITALSYIVACFDTNLVPPTLLGLSILYAISSAIFRAVCLEKALHVTERDANKLYNVQVFCGVFALLFATIIFEPEFFLSVQSKSFSEFILSIGCLVTVGTIPFVKNIIANKLVTIGQQAPWRFSEIVSVALFFVFGVIFFECDITITIIISFILVISGRTMSMVDIINNDNKRHSGSHHKKRHAPKNTLAFNDVHEDTAAQIADPPMRDMSMQDSPNGYEGDHESEMDHEAINEQGIIDQDDVDPESGIVQNENEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYZ0</accession>
    <name>Q5CYZ0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RNA polymerase II subunit B1 CTD phosphatase RPAP2 homolog</fullName>
            <ecNumber evidence="12">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd7_500</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="9 12">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 12">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11 12">Belongs to the RPAP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="12"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90536.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628240.1">
        <property type="nucleotide sequence ID" value="XM_628238.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYZ0"/>
    <dbReference type="STRING" id="353152.Q5CYZ0"/>
    <dbReference type="GeneID" id="3371911"/>
    <dbReference type="KEGG" id="cpv:cgd7_500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_500"/>
    <dbReference type="InParanoid" id="Q5CYZ0"/>
    <dbReference type="OMA" id="EYWIRTH"/>
    <dbReference type="OrthoDB" id="2590500at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043175">
        <property type="term" value="F:RNA polymerase core enzyme binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008420">
        <property type="term" value="F:RNA polymerase II CTD heptapeptide repeat phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039693">
        <property type="entry name" value="Rtr1/RPAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007308">
        <property type="entry name" value="Rtr1/RPAP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038534">
        <property type="entry name" value="Rtr1/RPAP2_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14732:SF0">
        <property type="entry name" value="RNA POLYMERASE II SUBUNIT B1 CTD PHOSPHATASE RPAP2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04181">
        <property type="entry name" value="RPAP2_Rtr1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51479">
        <property type="entry name" value="ZF_RTR1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="13" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 12" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RTR1-type" evidence="15">
        <location>
            <begin position="52"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="283"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="351"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="13">
        <location>
            <begin position="164"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="14">
        <location>
            <begin position="288"/>
            <end position="297"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="351"/>
            <end position="374"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="14">
        <location>
            <begin position="375"/>
            <end position="386"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00812"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU367080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51479"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK90536.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="576" mass="67649" checksum="22D1CD386667D13E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPN0</accession>
    <name>A3FPN0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Peptidylprolyl isomerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_1520</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51569.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388376.1">
        <property type="nucleotide sequence ID" value="XM_001388339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPN0"/>
    <dbReference type="STRING" id="353152.A3FPN0"/>
    <dbReference type="GeneID" id="3371782"/>
    <dbReference type="KEGG" id="cpv:cgd7_1520"/>
    <dbReference type="InParanoid" id="A3FPN0"/>
    <dbReference type="OMA" id="CMIKLQE"/>
    <dbReference type="OrthoDB" id="424948at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF0">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13431">
        <property type="entry name" value="TPR_17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0413">Isomerase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="29"/>
            <end position="62"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51569.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="83" mass="9511" checksum="B0B19157CDE34DB9" modified="2007-04-03" version="1" fragment="single">SSSCMIKLQEYKSVLKYCTETLKLDKNNVKALYLRASSYLKLDDPDEARIDLYKAATIEPQNIEVRTKLQQVSLILSFLLISP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPN3</accession>
    <name>A3FPN3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Rab7 GTPase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_1680</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51572.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388379.1">
        <property type="nucleotide sequence ID" value="XM_001388342.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPN3"/>
    <dbReference type="FunCoup" id="A3FPN3">
        <property type="interactions" value="315"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPN3"/>
    <dbReference type="GeneID" id="3371785"/>
    <dbReference type="KEGG" id="cpv:cgd7_1680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1680"/>
    <dbReference type="InParanoid" id="A3FPN3"/>
    <dbReference type="OMA" id="TSWKDEF"/>
    <dbReference type="OrthoDB" id="1436450at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01862">
        <property type="entry name" value="Rab7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000086">
        <property type="entry name" value="Ras-related small GTPase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981">
        <property type="entry name" value="RAB FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47981:SF20">
        <property type="entry name" value="RAS-RELATED PROTEIN RAB-7A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5" id="KW-0636">Prenylation</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51572.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="215" mass="24145" checksum="F1BB578CF7076FE5" modified="2007-04-03" version="1">MSMVQSKSNRKRVLLKVIILGDSGVGKTSLMNQYVNSKFSTQYKATIGADFLTKDIVIDNKLVTLQIWDTAGQERFQSLGVAFYRGADCCALVYDMTNPKSFEGLDAWREEFLIQATPKDPNSFPFVVLGNKLDLDQKSRKVSSQKASAWCKSKNIEYFETSAKNATNVDAAFEEIGRRALYRETSEDQVYIPEPLTLNNNNQQHHEIGFGGCSC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPP8</accession>
    <name>A3FPP8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Transcription activator, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_3240</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388394.1">
        <property type="nucleotide sequence ID" value="XM_001388357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPP8"/>
    <dbReference type="FunCoup" id="A3FPP8">
        <property type="interactions" value="189"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPP8"/>
    <dbReference type="GeneID" id="3371836"/>
    <dbReference type="KEGG" id="cpv:cgd7_3240"/>
    <dbReference type="InParanoid" id="A3FPP8"/>
    <dbReference type="OrthoDB" id="5585087at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005666">
        <property type="term" value="C:RNA polymerase III complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.30:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerases II, IV and V subunit 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.30">
        <property type="entry name" value="RNA polymerase ii, chain L"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006591">
        <property type="entry name" value="RNAP_P/RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039747">
        <property type="entry name" value="RPABC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029040">
        <property type="entry name" value="RPABC4/Spt4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASES I, II, AND III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12056:SF2">
        <property type="entry name" value="GEO11084P1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03604">
        <property type="entry name" value="Zn_ribbon_RPAB4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00659">
        <property type="entry name" value="RPOLCX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63393">
        <property type="entry name" value="RNA polymerase subunits"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025770"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="49" mass="5538" checksum="3F388171CAE57D26" modified="2007-04-03" version="1" fragment="single">MVEPVTYICGECGADVSLLSHGAAVRCRTCGCRILYKKRTRKMIQYEAR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="31" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPR8</accession>
    <name>A3FPR8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_4890</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388414.1">
        <property type="nucleotide sequence ID" value="XM_001388377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPR8"/>
    <dbReference type="GeneID" id="3371816"/>
    <dbReference type="KEGG" id="cpv:cgd7_4890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4890"/>
    <dbReference type="InParanoid" id="A3FPR8"/>
    <dbReference type="OrthoDB" id="342719at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002652617" evidence="2">
        <location>
            <begin position="27"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="290"/>
            <end position="339"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="399" mass="47350" checksum="6C8D5680042F2A30" modified="2007-04-03" version="1">MIFEPKKVLLFLILSLFNIFIQFKEAYSNDPALVTFIENIKLTRNENNHMIQITKKEEECFRFFPTYFSELGETELTGKQKKEILSLIKYNFISWVNYNDNIQILNSEDHILTSMEKSQLVEKLKESDFQSLTLTENYAMYNILFNDTNYNGAFNILNVCDNSKFYKGVSTLDKTHTFQKYDQIEFILSSEKSDKTLIVDEREIGIERKNEFNPEDNDSLEKIINDYSNSRNLFIYNNNFNFEDTKTIDGLNNDVSNLKYSTRNLKTPFKVKVTKDINNIQDDNLFVEKNREEKNLNEKVRNEKVEKEEIPESYEDIPRNKQKEDVKKLEKNIKKRNVLKNGEKELNEGKSNSNDTHLVRKKTNLREKKECKKLYKSINNNRFYIDTRPIISNDVYLVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="33" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPS1</accession>
    <name>A3FPS1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388300.1">
        <property type="nucleotide sequence ID" value="XM_001388263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPS1"/>
    <dbReference type="GeneID" id="3375926"/>
    <dbReference type="KEGG" id="cpv:cgd6_600"/>
    <dbReference type="InParanoid" id="A3FPS1"/>
    <dbReference type="OMA" id="NVNHANS"/>
    <dbReference type="OrthoDB" id="72772at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="151"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="356" mass="42115" checksum="98C65166DBD91CEC" modified="2007-04-03" version="1" fragment="single">LSQSIISEFIFPNSILQYSNSRLFLTLLSSNNQELIWSSNTFLMNNFIKYKTIDEVENNQINDDNTMIYLTTLQSNNGNKIIERSIRLHRLLAKYRNHLENYHSLKLKCAHQNKWITNDNNSNNQPFQSIFHFNNNQINKNESQLLNNNDLDIINLKKKQEKEKIDNYIKEFESKHNELIELINQNKMDIEKNTYNIIELNKEINIYRNDLINKISYCIYPISIEKKTSNFKIRNMLLPLINVIQNLDNKQDLEISTTLGFSLHYLQLIYNILELPCSNNIIVKGSFSTINNNPLYSYPNMNKKQITKALKLYKSIIYNILNYFNVNHANSKKILFTNNILLMLLTVTSYMKNYQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ93</accession>
    <name>A3FQ93_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">60S ribosomal protein L13</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_2990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the eukaryotic ribosomal protein eL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388229.1">
        <property type="nucleotide sequence ID" value="XM_001388192.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ93"/>
    <dbReference type="FunCoup" id="A3FQ93">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQ93"/>
    <dbReference type="GeneID" id="3373544"/>
    <dbReference type="KEGG" id="cpv:cgd2_2990"/>
    <dbReference type="InParanoid" id="A3FQ93"/>
    <dbReference type="OMA" id="HWHKRIK"/>
    <dbReference type="OrthoDB" id="10264538at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00499">
        <property type="entry name" value="Ribosomal_eL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001380">
        <property type="entry name" value="Ribosomal_eL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018256">
        <property type="entry name" value="Ribosomal_eL13_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11722:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01294">
        <property type="entry name" value="Ribosomal_L13e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01104">
        <property type="entry name" value="RIBOSOMAL_L13E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4 5" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000572"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="207" mass="23763" checksum="A98F03D84267FB1E" modified="2007-04-03" version="1">MRHNNVIPNVHYHKNYKRWIKTWYNQPGRKQSRRIARQKAVAEAGFRPVGMLRPIVHPPTQRYNMKTRLGRGFTLEELSACGINKKAAMSIGIAVDHRRTDLSEETFQINVDRLKKYINGIVLQPRKGKKTKKGFAGIPNDSAREEFKALKNVSHEKAFPIKAQTLAVKTHVITPEERKFRAFSTLRKQFIEAKNFGKKATKAKASA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQG7</accession>
    <name>A3FQG7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">70 kDa peptidylprolyl isomerase, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_430</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51273.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388251.1">
        <property type="nucleotide sequence ID" value="XM_001388214.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQG7"/>
    <dbReference type="GeneID" id="3373030"/>
    <dbReference type="KEGG" id="cpv:cgd5_430"/>
    <dbReference type="InParanoid" id="A3FQG7"/>
    <dbReference type="OMA" id="CFLKINE"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016853">
        <property type="term" value="F:isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039663">
        <property type="entry name" value="AIP/AIPL1/TTC9"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242">
        <property type="entry name" value="ARYL HYDROCARBON RECEPTOR INTERACTING PROTEIN RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11242:SF0">
        <property type="entry name" value="TPR_REGION DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51273.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="79" mass="9357" checksum="0917E0CDC7C17342" modified="2007-04-03" version="1" fragment="single">EGNIKYKDNKIEEAILEYKNALIYVDYTFPENKNLEEEYNQLITRINLNLSACFLKINEFNMAMLHCNNVLKNDPNNIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQL5</accession>
    <name>A3FQL5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase</fullName>
            <ecNumber evidence="3">2.4.1.131</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd4_2990</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>an alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;2)-alpha-D-Man-(1-&gt;3)-[alpha-D-Man-(1-&gt;6)]-beta-D-Man-(1-&gt;4)-beta-D-GlcNAc-(1-&gt;4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + 2 GDP + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:29523"/>
            <dbReference type="Rhea" id="RHEA-COMP:19515"/>
            <dbReference type="Rhea" id="RHEA-COMP:19516"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57527"/>
            <dbReference type="ChEBI" id="CHEBI:58189"/>
            <dbReference type="ChEBI" id="CHEBI:132511"/>
            <dbReference type="ChEBI" id="CHEBI:132515"/>
            <dbReference type="EC" id="2.4.1.131"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="11">
            <dbReference type="Rhea" id="RHEA:29524"/>
        </physiologicalReaction>
    </comment>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.4.1.131" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51258.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388070.1">
        <property type="nucleotide sequence ID" value="XM_001388033.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQL5"/>
    <dbReference type="STRING" id="353152.A3FQL5"/>
    <dbReference type="GeneID" id="3372820"/>
    <dbReference type="KEGG" id="cpv:cgd4_2990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2990"/>
    <dbReference type="InParanoid" id="A3FQL5"/>
    <dbReference type="OMA" id="ARLYGWV"/>
    <dbReference type="OrthoDB" id="2276068at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004377">
        <property type="term" value="F:GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006487">
        <property type="term" value="P:protein N-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038013">
        <property type="entry name" value="ALG11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031814">
        <property type="entry name" value="ALG11_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001296">
        <property type="entry name" value="Glyco_trans_1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45919:SF1">
        <property type="entry name" value="GDP-MAN:MAN(3)GLCNAC(2)-PP-DOL ALPHA-1,2-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15924">
        <property type="entry name" value="ALG11_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00534">
        <property type="entry name" value="Glycos_transf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="5" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="10" id="KW-0472">Membrane</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6 14" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="domain" description="ALG11 mannosyltransferase N-terminal" evidence="13">
        <location>
            <begin position="15"/>
            <end position="209"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyl transferase family 1" evidence="12">
        <location>
            <begin position="237"/>
            <end position="406"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012645"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00045065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00534"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF15924"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAZ51258.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="447" mass="52059" checksum="48056E080B19449B" modified="2007-04-03" version="1">MIFNSFKIWKEERKSTIGFFHPQCGNFGGGEKVLWCIIYEVLNANIKNKVVIYSTCKLDKTELVKKVESLFRIPLNRPEFVYRIKIVELKLGFLLQLAFFRLWSVNLAALIVSLEGLLFSWPFPEVFVETAGFPFALIPARVLPTTKHISTYIHYPQVRKENIESEKERNILRYFYLKLFLFVYKLSIGLANKVVVNSNWTFNKLNELWEKNSIEMSVCYPPINIDHSLNKLVDPKLRKNVIISLSQFRVEKNHFVQIRIFSGVLKRIKEIINRASKEEKIRLEKIYEEIRFKMCGTSQNSNPKYNDYLNSLKQMIVDEKLEEKLELVIDSSSTELQNIMRTSRFAIHTMEDEHFGICVAEFVCSGLLTFAHKSGGPEKDILTRFDGQDVGFLASNIQEFVEKLAHAIIYYEDPAIQGILNNALKSVFERYQDNISFGKTCWRALNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQN3</accession>
    <name>A3FQN3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">HSA domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd4_510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAZ51239.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388051.1">
        <property type="nucleotide sequence ID" value="XM_001388014.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQN3"/>
    <dbReference type="GeneID" id="3372629"/>
    <dbReference type="KEGG" id="cpv:cgd4_510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_510"/>
    <dbReference type="InParanoid" id="A3FQN3"/>
    <dbReference type="OMA" id="DERIMHV"/>
    <dbReference type="OrthoDB" id="372624at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006325">
        <property type="term" value="P:chromatin organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014012">
        <property type="entry name" value="HSA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052145">
        <property type="entry name" value="Mediator/Homeobox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330">
        <property type="entry name" value="HOMEOBOX PROTEIN BARH-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24330:SF19">
        <property type="entry name" value="MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 29"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07529">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00573">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51204">
        <property type="entry name" value="HSA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HSA" evidence="4">
        <location>
            <begin position="21"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="500"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="235"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="405"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="580"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="666"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="751"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="962"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1218"/>
            <end position="1506"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="243"/>
            <end position="271"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="580"/>
            <end position="589"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="593"/>
            <end position="605"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="666"/>
            <end position="675"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="757"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="771"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="962"/>
            <end position="977"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="978"/>
            <end position="989"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1246"/>
            <end position="1360"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1368"/>
            <end position="1390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1407"/>
            <end position="1423"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1462"/>
            <end position="1472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1481"/>
            <end position="1500"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51239.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="7">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1805" mass="193417" checksum="DCC7CED3DDD05D1F" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQQ5</accession>
    <name>A3FQQ5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Maspardin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd4_4130</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAZ51217.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388084.1">
        <property type="nucleotide sequence ID" value="XM_001388047.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQQ5"/>
    <dbReference type="GeneID" id="3372411"/>
    <dbReference type="KEGG" id="cpv:cgd4_4130"/>
    <dbReference type="InParanoid" id="A3FQQ5"/>
    <dbReference type="OMA" id="SVQYPIY"/>
    <dbReference type="OrthoDB" id="10264550at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000073">
        <property type="entry name" value="AB_hydrolase_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026151">
        <property type="entry name" value="Maspardin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15913">
        <property type="entry name" value="ACID CLUSTER PROTEIN 33"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15913:SF0">
        <property type="entry name" value="MASPARDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00561">
        <property type="entry name" value="Abhydrolase_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AB hydrolase-1" evidence="4">
        <location>
            <begin position="105"/>
            <end position="199"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00020148"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51217.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="316" mass="36712" checksum="6EB9AABA4CA5264B" modified="2007-04-03" version="1">MVRRLSSEFGDFIESYPLKRTTIPYLDGIWTWIDCNPKNVEKITKIVSQESITDIEDITEDYYSRKTVKXLXXXDXXXLXKLNSXSLKYNNNNNNEKYESNEFDIIVILHGLSGTAGEYFMFMKNMLKCGYRIISVQYPIYDDINDWIRSFSLFLDQLELDSIHLYGSDLGGYLSIMFSQEFPNRVKSLILCNAFVSTLNLPLPSIASTFLYFCPQFILVKLISEIFKNREILYSPIEDMGFYSTVTNIHKDNNLYDKLYNXIIKFVIGQLYSLSNHDLASRLSFVLSGDETLSILNLTKFSSILDNKRITFYFKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQR1</accession>
    <name>A3FQR1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Notchless</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAZ51212.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388187.1">
        <property type="nucleotide sequence ID" value="XM_001388150.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQR1"/>
    <dbReference type="FunCoup" id="A3FQR1">
        <property type="interactions" value="304"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQR1"/>
    <dbReference type="GeneID" id="3372351"/>
    <dbReference type="KEGG" id="cpv:cgd2_330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_330"/>
    <dbReference type="InParanoid" id="A3FQR1"/>
    <dbReference type="OMA" id="AWEPYHR"/>
    <dbReference type="OrthoDB" id="10267436at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020472">
        <property type="entry name" value="WD40_PAC1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848:SF0">
        <property type="entry name" value="NOTCHLESS PROTEIN HOMOLOG 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19848">
        <property type="entry name" value="WD40 REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00320">
        <property type="entry name" value="GPROTEINBRPT"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="8"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="7">
        <location>
            <begin position="38"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="135"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="177"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="266"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="289"/>
            <end position="331"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="418"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="460"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="502"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="13"/>
            <end position="35"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51212.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="535" mass="59898" checksum="3F43FE7028D85109" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQR5</accession>
    <name>A3FQR5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="18">Coatomer subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd6_270</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasmic vesicle</location>
            <location evidence="2">COPI-coated vesicle membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Golgi apparatus membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
            <orientation evidence="1">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAZ51207.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388296.1">
        <property type="nucleotide sequence ID" value="XM_001388259.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A3FQR5">
        <property type="interactions" value="504"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQR5"/>
    <dbReference type="GeneID" id="3375659"/>
    <dbReference type="KEGG" id="cpv:cgd6_270"/>
    <dbReference type="InParanoid" id="A3FQR5"/>
    <dbReference type="OrthoDB" id="10261439at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030126">
        <property type="term" value="C:COPI vesicle coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000139">
        <property type="term" value="C:Golgi membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005198">
        <property type="term" value="F:structural molecule activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006888">
        <property type="term" value="P:endoplasmic reticulum to Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006891">
        <property type="term" value="P:intra-Golgi vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011710">
        <property type="entry name" value="Coatomer_bsu_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016460">
        <property type="entry name" value="COPB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029446">
        <property type="entry name" value="COPB1_appendage_platform_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10635:SF0">
        <property type="entry name" value="COATOMER SUBUNIT BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07718">
        <property type="entry name" value="Coatamer_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14806">
        <property type="entry name" value="Coatomer_b_Cpla"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="11" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0968">Cytoplasmic vesicle</keyword>
    <keyword evidence="6" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="9" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-0653">Protein transport</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="13">
        <location>
            <begin position="21"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit C-terminal" evidence="14">
        <location>
            <begin position="935"/>
            <end position="1047"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="15">
        <location>
            <begin position="1077"/>
            <end position="1141"/>
        </location>
    </feature>
    <feature type="domain" description="Coatomer beta subunit appendage platform" evidence="15">
        <location>
            <begin position="1191"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="381"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="595"/>
            <end position="628"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1168"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="11">
        <location>
            <begin position="807"/>
            <end position="834"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="381"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="615"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="unsure residue" description="D or N" evidence="16">
        <location>
            <position position="763"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004255"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004347"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="Pfam" id="PF07718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="Pfam" id="PF14806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAZ51207.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="18">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1330" mass="151056" checksum="8B2301AD6C234285" modified="2013-05-29" version="2"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPJ6</accession>
    <name>Q5CPJ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Possible Na+/H+ and K+/H+ antiporter with 12 transmembrane domains, duplicated adjacent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_130</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87339.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625353.1">
        <property type="nucleotide sequence ID" value="XM_625353.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPJ6"/>
    <dbReference type="STRING" id="353152.Q5CPJ6"/>
    <dbReference type="GeneID" id="3375670"/>
    <dbReference type="KEGG" id="cpv:cgd6_130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_130"/>
    <dbReference type="InParanoid" id="Q5CPJ6"/>
    <dbReference type="OMA" id="KNEAMEH"/>
    <dbReference type="OrthoDB" id="441412at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015386">
        <property type="term" value="F:potassium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015385">
        <property type="term" value="F:sodium:proton antiporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051453">
        <property type="term" value="P:regulation of intracellular pH"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098719">
        <property type="term" value="P:sodium ion import across plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018422">
        <property type="entry name" value="Cation/H_exchanger_CPA1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006153">
        <property type="entry name" value="Cation/H_exchanger_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110">
        <property type="entry name" value="SODIUM/HYDROGEN EXCHANGER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10110:SF86">
        <property type="entry name" value="SODIUM_HYDROGEN EXCHANGER 7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00999">
        <property type="entry name" value="Na_H_Exchanger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="7" id="KW-0406">Ion transport</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0915">Sodium</keyword>
    <keyword evidence="9" id="KW-0739">Sodium transport</keyword>
    <keyword evidence="4 10 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="16"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="49"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="114"/>
            <end position="140"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="220"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="254"/>
            <end position="284"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="337"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="375"/>
            <end position="394"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="domain" description="Cation/H+ exchanger transmembrane" evidence="11">
        <location>
            <begin position="45"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00999"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK87339.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="871" mass="98645" checksum="A59F25C071887272" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPL8</accession>
    <name>Q5CPL8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L39</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_350</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL39 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87395.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625403.1">
        <property type="nucleotide sequence ID" value="XM_625403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPL8"/>
    <dbReference type="FunCoup" id="Q5CPL8">
        <property type="interactions" value="105"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPL8"/>
    <dbReference type="GeneID" id="3372345"/>
    <dbReference type="KEGG" id="cpv:cgd2_350"/>
    <dbReference type="InParanoid" id="Q5CPL8"/>
    <dbReference type="OMA" id="RRTKMNI"/>
    <dbReference type="OrthoDB" id="444696at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.1620.10:FF:000001">
        <property type="entry name" value="60S ribosomal protein-like L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1620.10">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000077">
        <property type="entry name" value="Ribosomal_eL39"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023626">
        <property type="entry name" value="Ribosomal_eL39_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970:SF0">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN EL39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19970">
        <property type="entry name" value="RIBOSOMAL PROTEIN L39E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00832">
        <property type="entry name" value="Ribosomal_L39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48662">
        <property type="entry name" value="Ribosomal protein L39e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87395.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="55" mass="6717" checksum="174F8017F8E431B7" modified="2005-04-12" version="1" fragment="single">KVDEMGANKGFMLKKRLGKKMKQNRAVPHWFRMKNDTDIRYNVKKRHWLRTKLGM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPM7</accession>
    <name>Q5CPM7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">V-type proton ATPase subunit G</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase G subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87377.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625394.1">
        <property type="nucleotide sequence ID" value="XM_625394.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPM7"/>
    <dbReference type="FunCoup" id="Q5CPM7">
        <property type="interactions" value="31"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPM7"/>
    <dbReference type="GeneID" id="3372361"/>
    <dbReference type="KEGG" id="cpv:cgd2_250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_250"/>
    <dbReference type="InParanoid" id="Q5CPM7"/>
    <dbReference type="OMA" id="PDCTQKS"/>
    <dbReference type="OrthoDB" id="250802at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000221">
        <property type="term" value="C:vacuolar proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.2950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005124">
        <property type="entry name" value="V-ATPase_G"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713:SF11">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12713">
        <property type="entry name" value="VACUOLAR ATP SYNTHASE SUBUNIT G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03179">
        <property type="entry name" value="V-ATPase_G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4" id="KW-0406">Ion transport</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="15"/>
            <end position="60"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK87377.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="8">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="130" mass="14371" checksum="F4953E59307DED6F" modified="2005-04-12" version="1">MSATGKNGTGSSALIQKLMDAEVDAEEIVRRAKENRILKLKEAQISAEEELKAFREKEEAQFESEFKNFSVEDSVDQTLEKSTEEAIEIVKNDFKNNGGAVADLILKKVLSVDLSLPPTVTHLAKIGKIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPN4</accession>
    <name>Q5CPN4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd2_180</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87383.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625387.1">
        <property type="nucleotide sequence ID" value="XM_625387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPN4"/>
    <dbReference type="FunCoup" id="Q5CPN4">
        <property type="interactions" value="325"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPN4"/>
    <dbReference type="GeneID" id="3372367"/>
    <dbReference type="KEGG" id="cpv:cgd2_180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_180"/>
    <dbReference type="InParanoid" id="Q5CPN4"/>
    <dbReference type="OMA" id="FIDNILC"/>
    <dbReference type="OrthoDB" id="205794at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008380">
        <property type="term" value="P:RNA splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008409">
        <property type="entry name" value="SPF27"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05700">
        <property type="entry name" value="BCAS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0747">Spliceosome</keyword>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="121"/>
            <end position="181"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87383.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="200" mass="23293" checksum="6F89EF40E9D02331" modified="2005-04-12" version="1">MNMVDELKTTCGGDGYSCEKLVNAYNVLSYIDGISTEEMEYANKLIKEELSSVLNEVGKGNDKIKEITLEDEKKNEENDNDIIGHEIHENETISHIKKIGLEIQYNYITKVNLQLLKEFGDEAWNDQVKKLKSHKQRLQEEQSDLKKSMKQISFNRKKRQLELQENQLNPLLEELKIIRKENNSLIKSLIKKIKKEKGIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPZ6</accession>
    <name>Q5CPZ6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_190</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87472.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625483.1">
        <property type="nucleotide sequence ID" value="XM_625483.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPZ6"/>
    <dbReference type="FunCoup" id="Q5CPZ6">
        <property type="interactions" value="84"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPZ6"/>
    <dbReference type="GeneID" id="3372502"/>
    <dbReference type="KEGG" id="cpv:cgd8_190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_190"/>
    <dbReference type="InParanoid" id="Q5CPZ6"/>
    <dbReference type="OMA" id="ACMHKSS"/>
    <dbReference type="OrthoDB" id="4310724at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 7 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="11">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="9">
        <location>
            <begin position="206"/>
            <end position="469"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="10">
        <location>
            <begin position="585"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="56"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="459"/>
            <end position="482"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="6">
        <location>
            <begin position="174"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="65"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="463"/>
            <end position="472"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK87472.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="837" mass="94809" checksum="7277548BA64F7905" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ36</accession>
    <name>Q5CQ36_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_4280</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625590.1">
        <property type="nucleotide sequence ID" value="XM_625590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ36"/>
    <dbReference type="GeneID" id="3372574"/>
    <dbReference type="KEGG" id="cpv:cgd5_4280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4280"/>
    <dbReference type="InParanoid" id="Q5CQ36"/>
    <dbReference type="OrthoDB" id="342353at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253737" evidence="2">
        <location>
            <begin position="22"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="360"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="494" mass="56886" checksum="CDF75A699E0C4653" modified="2005-04-12" version="1">MDREFFVLLVIAILMSLRISCYKCDNQAVKNVKPIISELFDMLLENIEAKRKEEIQFNETFLENGKDLNHYIDNNKPTKLTKITNTIYEANQDKVEIIDREISILDGQMSLRLGIVVNLLYGNQSVLVLKLWNESYSKISKNYSLLCSSSNINSNFITNPSEYREIHNTNKNYLLFEMKQEISNINEKTFLLCLSDSITSNHSIYITKLSFSSNNELKETNHYKEKNLNQFEEFESKSDLVGKHEILELNQQENDDQILVRTKVPSGQNCSDFKLILLSNQKNSITNGELLPETKTTNNYENICFWSLKLENTQFKDSNLLEIVQRHKNSGATFTIAKVNPTPINYKYGKRSQFMLSKSFLFKILLLVLNLIPVTLLTLGVYLIIAEIWTIISSKVLENKKCLSNAIFKSSKCQQRTNVSKKTISNRENDTNNNWIDKRKETKPIQFSSFNIVTSKNLNSEESGFSSGENEPVVKGDPYRYFDSDCSISTHTGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ60</accession>
    <name>Q5CQ60_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_4020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625566.1">
        <property type="nucleotide sequence ID" value="XM_625566.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ60"/>
    <dbReference type="GeneID" id="3372519"/>
    <dbReference type="KEGG" id="cpv:cgd5_4020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4020"/>
    <dbReference type="InParanoid" id="Q5CQ60"/>
    <dbReference type="OrthoDB" id="21123at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="35"/>
            <end position="63"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="151" mass="18408" checksum="A472A170F6BED38B" modified="2005-04-12" version="1">MELKHMKIVDDYKKKRDEFCQANLKLTTSEKNIKFRKSSLSRSPERPSEPYFSNNYKHQNDSRKKYNIHTHVNRRNKNNHHLSKSDREEKLQKMINYGKLTQNERIKKFNAKSNISNKEPAKHREYLHEMRNKINQKQISSLEERMKFMKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQB2</accession>
    <name>Q5CQB2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">inorganic diphosphatase</fullName>
            <ecNumber evidence="3">3.6.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_1400</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.1.1" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625736.1">
        <property type="nucleotide sequence ID" value="XM_625736.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQB2"/>
    <dbReference type="SMR" id="Q5CQB2"/>
    <dbReference type="FunCoup" id="Q5CQB2">
        <property type="interactions" value="205"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQB2"/>
    <dbReference type="GeneID" id="3372640"/>
    <dbReference type="KEGG" id="cpv:cgd4_1400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1400"/>
    <dbReference type="InParanoid" id="Q5CQB2"/>
    <dbReference type="OMA" id="LYANEQK"/>
    <dbReference type="OrthoDB" id="1608002at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004427">
        <property type="term" value="F:inorganic diphosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006796">
        <property type="term" value="P:phosphate-containing compound metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00412">
        <property type="entry name" value="pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.80.10">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008162">
        <property type="entry name" value="Pyrophosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036649">
        <property type="entry name" value="Pyrophosphatase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10286">
        <property type="entry name" value="INORGANIC PYROPHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00719">
        <property type="entry name" value="Pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50324">
        <property type="entry name" value="Inorganic pyrophosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00387">
        <property type="entry name" value="PPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006220"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="383" mass="43392" checksum="7B1AC86D8B9A5CD4" modified="2005-04-12" version="1">MSTEYRVGFASKEDIIEKSTYGECEDRTKSLSFSSDVNSITYDEASSSSEEYPEYSLLRTQSSLAPPIEASAIVDVEEAWKALSKELEESHSKPTIRTLGTVFVTREEVGTKDSIEYRLFYKNEDGYKISPWHDVPLWFSETPLLYNMIIEIPKLTNKKFEINTKEEYTPLYQDRKLERLRTYPGPIPWNYGAFPQTWEDPNKKGDENVDFSHGDNDPLDAVEIGVGPLPRGTIIQVKILGCLALIDDDELDWKVVCIRVCDPHASQLNDITDVEKYFPGTIDRIRRWFGLYKAVENKDVAKVNMYGHFGEPQSAEFAHSVILETHHSYLRLIRGEAMNSSSLWIPKSLSNNGETELCHTVCSTNSTATVSSNDIGGLSVNDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQE7</accession>
    <name>Q5CQE7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87639.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625701.1">
        <property type="nucleotide sequence ID" value="XM_625701.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQE7"/>
    <dbReference type="GeneID" id="3372682"/>
    <dbReference type="KEGG" id="cpv:cgd4_1000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1000"/>
    <dbReference type="InParanoid" id="Q5CQE7"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="12"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="24"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="47"/>
            <end position="116"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87639.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="153" mass="15283" checksum="3C69BB93A35709F0" modified="2005-04-12" version="1">MLEMILVINNPGREERGAKEGRGRMKRRMKRRKMRRRMGRARGKYDSGSSGSSSSGSSSNGSSSNGSSSNGSSSNGSSSNGSSSNGSSSSGSSSSGSSSSGSSDSNGNSGSSGRSSCCSGSSSCCCSCCCSGSCCCSNSSISISISMRGTKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="117" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQF8</accession>
    <name>Q5CQF8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">ADA2 ortholog with a ZZ finger, SANT domain and a SWIRM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_880</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87649.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625690.1">
        <property type="nucleotide sequence ID" value="XM_625690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQF8"/>
    <dbReference type="SMR" id="Q5CQF8"/>
    <dbReference type="STRING" id="353152.Q5CQF8"/>
    <dbReference type="GeneID" id="3372694"/>
    <dbReference type="KEGG" id="cpv:cgd4_880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_880"/>
    <dbReference type="InParanoid" id="Q5CQF8"/>
    <dbReference type="OMA" id="YNGNHRP"/>
    <dbReference type="OrthoDB" id="270417at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006338">
        <property type="term" value="P:chromatin remodeling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02335">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.90">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041983">
        <property type="entry name" value="ADA2-like_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055141">
        <property type="entry name" value="TADA2A_B-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000433">
        <property type="entry name" value="Znf_ZZ"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043145">
        <property type="entry name" value="Znf_ZZ_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374:SF20">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTER 2-ALPHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12374">
        <property type="entry name" value="TRANSCRIPTIONAL ADAPTOR 2 ADA2 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22941">
        <property type="entry name" value="TADA2A-like_3rd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25299">
        <property type="entry name" value="ZZ_ADA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00291">
        <property type="entry name" value="ZnF_ZZ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01357">
        <property type="entry name" value="ZF_ZZ_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50135">
        <property type="entry name" value="ZF_ZZ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="ZZ-type" evidence="7">
        <location>
            <begin position="83"/>
            <end position="138"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="9">
        <location>
            <begin position="137"/>
            <end position="172"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="140"/>
            <end position="211"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="6">
        <location>
            <begin position="144"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="250"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="527"/>
            <end position="547"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="251"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="306"/>
            <end position="316"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00228"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50135"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87649.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="673" mass="76294" checksum="456DF305A07A6F0D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQG1</accession>
    <name>Q5CQG1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large protein with signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_850</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625687.1">
        <property type="nucleotide sequence ID" value="XM_625687.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372697"/>
    <dbReference type="KEGG" id="cpv:cgd4_850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_850"/>
    <dbReference type="InParanoid" id="Q5CQG1"/>
    <dbReference type="OMA" id="HANPRTR"/>
    <dbReference type="OrthoDB" id="342985at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254118" evidence="2">
        <location>
            <begin position="26"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1038"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1969"/>
            <end position="1995"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1046"/>
            <end position="1059"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="1060"/>
            <end position="1080"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1969"/>
            <end position="1981"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2091" mass="241690" checksum="DE2F44C5F0570A2F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQI1</accession>
    <name>Q5CQI1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RAD14/XpA, DNA excision repair protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd4_630</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625667.1">
        <property type="nucleotide sequence ID" value="XM_625667.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQI1"/>
    <dbReference type="STRING" id="353152.Q5CQI1"/>
    <dbReference type="GeneID" id="3372658"/>
    <dbReference type="KEGG" id="cpv:cgd4_630"/>
    <dbReference type="InParanoid" id="Q5CQI1"/>
    <dbReference type="OMA" id="CGFELTW"/>
    <dbReference type="OrthoDB" id="68328at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000110">
        <property type="term" value="C:nucleotide-excision repair factor 1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006284">
        <property type="term" value="P:base-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901255">
        <property type="term" value="P:nucleotide-excision repair involved in interstrand cross-link repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000715">
        <property type="term" value="P:nucleotide-excision repair, DNA damage recognition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070914">
        <property type="term" value="P:UV-damage excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd21075">
        <property type="entry name" value="DBD_XPA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.530.10">
        <property type="entry name" value="XPA C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009061">
        <property type="entry name" value="DNA-bd_dom_put_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000465">
        <property type="entry name" value="XPA/RAD14"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022656">
        <property type="entry name" value="XPA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037129">
        <property type="entry name" value="XPA_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10142:SF0">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-A CELLS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05181">
        <property type="entry name" value="XPA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46955">
        <property type="entry name" value="Putative DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="XPA C-terminal" evidence="4">
        <location>
            <begin position="44"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="199" mass="23197" checksum="B2454BD3123995B4" modified="2005-04-12" version="1" fragment="single">KMSHSCRSCRCDLGNNLSVAVEETLKSVGIYVCRRCFFQGKDDEYSKMTQTNAMKDYALSAQDLSGEGFAIVKKPTSYGKNRFMKLYYKFQVEEAAIKKYGSVEQALAESTNAEDRKIQKKINKRLGITSELSEKEQKKMEQKRLRIEKRLENENKKRMLKQESYHEHDFDPPVKINTESGLYKKKCKICGFELTWEEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQK4</accession>
    <name>Q5CQK4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein with a SET domain within carboxy region</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_370</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2013-06" db="PDB data bank">
            <title>Crystal Structure of CpSET8 from Cryptosporidium, cgd4_370.</title>
            <authorList>
                <person name="Wernimont A.K."/>
                <person name="Tempel W."/>
                <person name="Loppnau P."/>
                <person name="Bountra C."/>
                <person name="Arrowsmith C.H."/>
                <person name="Edwards A.M."/>
                <person name="Hui R."/>
                <person name="El Bakkouri M."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.31 ANGSTROMS) OF 280-556</scope>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625644.1">
        <property type="nucleotide sequence ID" value="XM_625644.1"/>
    </dbReference>
    <dbReference type="PDB" id="4LDG">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.31 A"/>
        <property type="chains" value="A=280-556"/>
    </dbReference>
    <dbReference type="PDBsum" id="4LDG"/>
    <dbReference type="AlphaFoldDB" id="Q5CQK4"/>
    <dbReference type="SMR" id="Q5CQK4"/>
    <dbReference type="STRING" id="353152.Q5CQK4"/>
    <dbReference type="GeneID" id="3372737"/>
    <dbReference type="KEGG" id="cpv:cgd4_370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_370"/>
    <dbReference type="InParanoid" id="Q5CQK4"/>
    <dbReference type="OMA" id="HIRNAYH"/>
    <dbReference type="OrthoDB" id="339390at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CQK4"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005700">
        <property type="term" value="C:polytene chromosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042799">
        <property type="term" value="F:histone H4K20 methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd10528">
        <property type="entry name" value="SET_SETD8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051760">
        <property type="entry name" value="KMT5A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047266">
        <property type="entry name" value="KMT5A-like_SET"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46167:SF1">
        <property type="entry name" value="N-LYSINE METHYLTRANSFERASE KMT5A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00317">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="4" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="1">
        <location>
            <begin position="402"/>
            <end position="540"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="4">
        <source>
            <dbReference type="PDB" id="4LDG"/>
        </source>
    </evidence>
    <sequence length="556" mass="65346" checksum="250D1E412E1E554C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQN9</accession>
    <name>Q5CQN9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Emap RNA binding domain protein (N terminal low complexity region)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_3880</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87740.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625963.1">
        <property type="nucleotide sequence ID" value="XM_625963.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQN9"/>
    <dbReference type="STRING" id="353152.Q5CQN9"/>
    <dbReference type="GeneID" id="3372912"/>
    <dbReference type="KEGG" id="cpv:cgd4_3880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3880"/>
    <dbReference type="InParanoid" id="Q5CQN9"/>
    <dbReference type="OMA" id="LMRWFDH"/>
    <dbReference type="OrthoDB" id="19141at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd02799">
        <property type="entry name" value="tRNA_bind_EMAP-II_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002547">
        <property type="entry name" value="tRNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051270">
        <property type="entry name" value="Tyrosine-tRNA_ligase_regulator"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586:SF33">
        <property type="entry name" value="AMINOACYL TRNA SYNTHASE COMPLEX-INTERACTING MULTIFUNCTIONAL PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11586">
        <property type="entry name" value="TRNA-AMINOACYLATION COFACTOR ARC1 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14497">
        <property type="entry name" value="GST_C_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01588">
        <property type="entry name" value="tRNA_bind"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50886">
        <property type="entry name" value="TRBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 3" id="KW-0820">tRNA-binding</keyword>
    <feature type="domain" description="GST C-terminal" evidence="5">
        <location>
            <begin position="54"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="domain" description="TRNA-binding" evidence="6">
        <location>
            <begin position="222"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="222"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022555"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87740.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="402" mass="45277" checksum="6DBB7F972F3216C6" modified="2005-04-12" version="1">MVILVKYSKTSNIGKVVSLLVNYLLKQNTELKIEESIIDENSTNEKNINQVVLIKDKENCNDQLESIVDILIYLGSFGKNLLGKDSSLINESKEIIEKLIKINFNFSKGTEMSEFNEMIKGKSFFLGRSLTIVDLVIYISLYSYFESLKDQNQDYIPEYPNLSTFFEQIQIVTLIRQSCPEGINYLDLPFFKKKLVKKEKKNTGEHGNNSNNNKQEERPLDDPTRIALRVGRILSVEKHPTADKLYLEKIDVGEDEPRTILSGLVGVYDLTQKINKLVVIVSNLKPRAMRGITSNGMLLCASSAPSGDNNNNNSQNQSSKEYCEPVSVPKDAKVGELIFYNDFKGEPDVVLNTKTGKDPFAAVQPNYNVSSDLLCRFKESTMMTSAGPVFVENKNLIHGKLS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQT5</accession>
    <name>Q5CQT5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative long chain fatty acyl CoA synthetase having a signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd4_3400</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87785.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625917.1">
        <property type="nucleotide sequence ID" value="XM_625917.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQT5"/>
    <dbReference type="SMR" id="Q5CQT5"/>
    <dbReference type="STRING" id="353152.Q5CQT5"/>
    <dbReference type="GeneID" id="3372870"/>
    <dbReference type="KEGG" id="cpv:cgd4_3400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3400"/>
    <dbReference type="InParanoid" id="Q5CQT5"/>
    <dbReference type="OMA" id="IWHSYER"/>
    <dbReference type="OrthoDB" id="1700726at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004467">
        <property type="term" value="F:long-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12780">
        <property type="entry name" value="N-terminal domain of ligase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042099">
        <property type="entry name" value="ANL_N_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272:SF33">
        <property type="entry name" value="AMP-BINDING DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43272">
        <property type="entry name" value="LONG-CHAIN-FATTY-ACID--COA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254132" evidence="3">
        <location>
            <begin position="23"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="4">
        <location>
            <begin position="168"/>
            <end position="564"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87785.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="766" mass="86086" checksum="D7B679B59BA637FB" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQW4</accession>
    <name>Q5CQW4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">cysteine desulfurase</fullName>
            <ecNumber evidence="3">2.8.1.7</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_3040</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>pyridoxal 5'-phosphate</name>
            <dbReference type="ChEBI" id="CHEBI:597326"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.8.1.7" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87808.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625888.1">
        <property type="nucleotide sequence ID" value="XM_625888.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQW4"/>
    <dbReference type="SMR" id="Q5CQW4"/>
    <dbReference type="FunCoup" id="Q5CQW4">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQW4"/>
    <dbReference type="GeneID" id="3372986"/>
    <dbReference type="KEGG" id="cpv:cgd4_3040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3040"/>
    <dbReference type="InParanoid" id="Q5CQW4"/>
    <dbReference type="OMA" id="KGLYWAR"/>
    <dbReference type="OrthoDB" id="10250117at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031071">
        <property type="term" value="F:cysteine desulfurase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051536">
        <property type="term" value="F:iron-sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016226">
        <property type="term" value="P:iron-sulfur cluster assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.640.10:FF:000003">
        <property type="entry name" value="Cysteine desulfurase IscS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.10">
        <property type="entry name" value="Aspartate Aminotransferase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.640.10">
        <property type="entry name" value="Type I PLP-dependent aspartate aminotransferase-like (Major domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000192">
        <property type="entry name" value="Aminotrans_V_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016454">
        <property type="entry name" value="Cysteine_dSase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015424">
        <property type="entry name" value="PyrdxlP-dep_Trfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015421">
        <property type="entry name" value="PyrdxlP-dep_Trfase_major"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015422">
        <property type="entry name" value="PyrdxlP-dep_Trfase_small"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF010611">
        <property type="entry name" value="PRK14012.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601:SF34">
        <property type="entry name" value="CYSTEINE DESULFURASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11601">
        <property type="entry name" value="CYSTEINE DESULFURYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00266">
        <property type="entry name" value="Aminotran_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005572">
        <property type="entry name" value="NifS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53383">
        <property type="entry name" value="PLP-dependent transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0408">Iron</keyword>
    <keyword evidence="8" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0663">Pyridoxal phosphate</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Aminotransferase class V" evidence="9">
        <location>
            <begin position="37"/>
            <end position="402"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022898"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF00266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK87808.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="438" mass="48714" checksum="8988FD4B48AA4E80" modified="2005-04-12" version="1">MIVHRYCRQWAPSVVRGISKLAFFSSMSSIAKKRPAYFDYQATTPVDPRVLDKMMPFFTEKFGNSHSRTHGYGWEAEEAVENARTNIANLIKCLPKEIIFTSGATESNNTIIRGVCDIYGDIENKKNHIITTQIEHKCVLSTLRELELKGFRVTYLKVNNKGLISLEELEKSIIPGETILASIMHVNNEIGVIQPMNLIGEICKKYNVLFHSDVAQGLGKINIDVDKWNADFLSLSAHKVYGPKGIGAFYIRSKPRRRIKPLIFGGGQERGMRSGTMPVPLAVGFGEACKIASSEMNSDSIHVKSLYDKLYKGITTQLPDVELNGCGVNRMFGNLNLSFTGVEGESLMMKLYSLALSSGSACTSASLEPSYVLRAIGVGEDVAHTSIRFGLGRFTKHEDVDKAVKEIVESVTLLRKMSPLWDSITDTKVKDEESLKWT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR52</accession>
    <name>Q5CR52_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin B like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_2070</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87879.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625800.1">
        <property type="nucleotide sequence ID" value="XM_625800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR52"/>
    <dbReference type="STRING" id="353152.Q5CR52"/>
    <dbReference type="GeneID" id="3372961"/>
    <dbReference type="KEGG" id="cpv:cgd4_2070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2070"/>
    <dbReference type="InParanoid" id="Q5CR52"/>
    <dbReference type="OMA" id="CKICISP"/>
    <dbReference type="OrthoDB" id="9983043at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd20537">
        <property type="entry name" value="CYCLIN_CCNO-like_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039361">
        <property type="entry name" value="Cyclin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10177">
        <property type="entry name" value="CYCLINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="135"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="3">
        <location>
            <begin position="332"/>
            <end position="428"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87879.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="437" mass="52041" checksum="E6DB9D151ECFEB1A" modified="2005-04-12" version="1">MTILFKKLKENETFKHFFRQVSKYLEGNSDESKENKSNISKCNLKTNYQLIKRENGKENNYISVNNTEFSSGIFEFSNNFEKSEYNESKPVKKFKFNIGQIFTNRILSKQNDYNMKRIYTYYRECYKKQIEPGKTLIDFRREIIGEMSEIIWKYHLNEEILFLTVHFMDNVIIKDQIEEENSLERLRYLGFTCLYITIKIERVVNFNFKEIIKKLSLNSIKLISMEKYVLNQLTFKLNPISSLFLLQFQMGIIMESYLKDIIGVENIDYSRKNSENKYFNYSYSDKYNSQIVQSYNSNRVGNEDQLENSSSLLINVLNMKSSKGINKVLEYFISCYLLEICLYDIEILKYSPLSQAVSALFIAKECLGARKDSIEEECINEYFNMEVLIEDYVYRNINAIKRTLKYPYIKKISTTKKYLTNEYMNAANYVLRLIYPK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRB1</accession>
    <name>Q5CRB1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Chaperone'DNAj domain protein chaperone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd5_3520</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion inner membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="7">Belongs to the TIM14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88044.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626275.1">
        <property type="nucleotide sequence ID" value="XM_626275.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRB1"/>
    <dbReference type="FunCoup" id="Q5CRB1">
        <property type="interactions" value="41"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRB1"/>
    <dbReference type="GeneID" id="3373102"/>
    <dbReference type="KEGG" id="cpv:cgd5_3520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3520"/>
    <dbReference type="InParanoid" id="Q5CRB1"/>
    <dbReference type="OrthoDB" id="240298at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001405">
        <property type="term" value="C:PAM complex, Tim23 associated import motor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030150">
        <property type="term" value="P:protein import into mitochondrial matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.110:FF:000001">
        <property type="entry name" value="Import inner membrane translocase subunit tim14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12763:SF28">
        <property type="entry name" value="GEO10507P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="8">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254289" evidence="8">
        <location>
            <begin position="20"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="domain" description="J" evidence="9">
        <location>
            <begin position="60"/>
            <end position="113"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00038105"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88044.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="113" mass="12507" checksum="7A6D88158364586E" modified="2005-04-12" version="1">MIWPFLMITAGASLVIARGTPILARRAGFFSRNMIRPLAGSTGKFPLKLKGFENPMSIREAYKILNVPPIASKARVREAHRQLMLRNHPDNGGSNYVASKVNEAKELICGDKD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRC7</accession>
    <name>Q5CRC7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Derlin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_3330</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Endoplasmic reticulum membrane</location>
            <topology evidence="1 7">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the derlin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88030.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626259.1">
        <property type="nucleotide sequence ID" value="XM_626259.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRC7"/>
    <dbReference type="FunCoup" id="Q5CRC7">
        <property type="interactions" value="215"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRC7"/>
    <dbReference type="GeneID" id="3373050"/>
    <dbReference type="KEGG" id="cpv:cgd5_3330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3330"/>
    <dbReference type="InParanoid" id="Q5CRC7"/>
    <dbReference type="OMA" id="FKSQYWR"/>
    <dbReference type="OrthoDB" id="1716531at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006950">
        <property type="term" value="P:response to stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007599">
        <property type="entry name" value="DER1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11009">
        <property type="entry name" value="DER1-LIKE PROTEIN, DERLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04511">
        <property type="entry name" value="DER1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 7" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="13"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="48"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="91"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="136"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU363059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88030.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="210" mass="24732" checksum="8E5DC4A9B68C6EBC" modified="2005-04-12" version="1">MLVVNNIPPVTKVYFAISTLLMVLCTLDIISPFNLYLNWLLVINEYQIWRLATCFFFFGTFSLHFFWNAYVLLYYCASLEDVVFHSRPADFLWMLITCSWMLLLLSYFFGAGYLFSGAVINVMTYIWGRRNPSARMSVFIFTVRAPYLPWVLMGMGLVIGWRPWDNLMGIIVGHTYYFFEDIYPLMPISNGFRLFKTPKIITKLMKQEQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRC9</accession>
    <name>Q5CRC9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3310</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88228.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626257.1">
        <property type="nucleotide sequence ID" value="XM_626257.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRC9"/>
    <dbReference type="STRING" id="353152.Q5CRC9"/>
    <dbReference type="GeneID" id="3373216"/>
    <dbReference type="KEGG" id="cpv:cgd5_3310"/>
    <dbReference type="InParanoid" id="Q5CRC9"/>
    <dbReference type="OMA" id="CELEIMD"/>
    <dbReference type="OrthoDB" id="308449at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051959">
        <property type="entry name" value="PAK1-Kinase_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675:SF1">
        <property type="entry name" value="P21-ACTIVATED PROTEIN KINASE-INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44675">
        <property type="entry name" value="PAK1 INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="1">
        <location>
            <begin position="36"/>
            <end position="77"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88228.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="374" mass="42032" checksum="D14DC7401637698B" modified="2005-04-12" version="1" fragment="single">ASIKDMDSKGNILVTASTDETMRIYNLKTRCDSGMLTKHQGSVTYVCLSWNYKYLISCGEDKVVCIWRCSNWDPIKSFDDIHNCIPISADFHPSLKLALTLDIEGNICMLNLIEGNLAAKFTVPGMEKNGQNLNRRYGLFTLIKFNISGTYYAVLSQRELIISNITDKEDWYLSYSITDFGVGPSQITSFCWITNQIFLVGFSNGLIRILQVTKQCLINLEITFTVSKTTSDEIKNPHLGNRIKGICIIGYNHLKDENLGNSNICGRLVTCDSSGIFVLFNFKLKFNKEIGNSLCELEIMDILDSDNRITCMTIEDKNPIDPLSLFLPSTSQENSESIVDKGCLSSTPTKGNKKLKVIKKSKLDNSKKKDNLKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRM6</accession>
    <name>Q5CRM6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Small nuclear ribonucleoprotein Sm D1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">snRNP core protein D1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd5_2220</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures.</text>
    </comment>
    <comment type="function">
        <text evidence="6">Involved in splicing regulation. Facilitates post-transcriptional gene silencing (PTGS) by limiting the degradation of transgene aberrant RNAs by the RNA quality control (RQC) machinery, thus favoring their entry into cytoplasmic siRNA bodies where they can trigger PTGS. Does not participate in the production of small RNAs.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the snRNP core protein family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88205.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626160.1">
        <property type="nucleotide sequence ID" value="XM_626160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRM6"/>
    <dbReference type="FunCoup" id="Q5CRM6">
        <property type="interactions" value="505"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRM6"/>
    <dbReference type="GeneID" id="3373343"/>
    <dbReference type="KEGG" id="cpv:cgd5_2220"/>
    <dbReference type="InParanoid" id="Q5CRM6"/>
    <dbReference type="OMA" id="TFLMKLT"/>
    <dbReference type="OrthoDB" id="9626941at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010468">
        <property type="term" value="P:regulation of gene expression"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000387">
        <property type="term" value="P:spliceosomal snRNP assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd01724">
        <property type="entry name" value="Sm_D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000008">
        <property type="entry name" value="Small nuclear ribonucleoprotein Sm D1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027141">
        <property type="entry name" value="LSm4/Sm_D1/D3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034102">
        <property type="entry name" value="Sm_D1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23338">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="7" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4 7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5 7 10" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="13"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="92"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00054531"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88205.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="137" mass="15379" checksum="BD95042D7FBE5453" modified="2005-04-12" version="1" fragment="single">IWLIHNTSRRKMKLIRFLMKLVNNSVVIELKNGTIIQGTIVTVDMSMNTYLKNVKMSVKHRNPVSLSQITVRGNTIRYFILPDSLPLDALLIDDTPKQNPPRVNPISGPKFGNKSTTNLSGGGNFDNKSRGSFGNRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRN7</accession>
    <name>Q5CRN7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">FCH domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_2090</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88060.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626149.1">
        <property type="nucleotide sequence ID" value="XM_626149.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRN7"/>
    <dbReference type="GeneID" id="3373259"/>
    <dbReference type="KEGG" id="cpv:cgd5_2090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2090"/>
    <dbReference type="InParanoid" id="Q5CRN7"/>
    <dbReference type="OMA" id="THLINRN"/>
    <dbReference type="OrthoDB" id="10255128at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043226">
        <property type="term" value="C:organelle"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.60">
        <property type="entry name" value="Arfaptin homology (AH) domain/BAR domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027267">
        <property type="entry name" value="AH/BAR_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031160">
        <property type="entry name" value="F_BAR_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001060">
        <property type="entry name" value="FCH_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065:SF7">
        <property type="entry name" value="NOSTRIN, ISOFORM H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23065">
        <property type="entry name" value="PROLINE-SERINE-THREONINE PHOSPHATASE INTERACTING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00611">
        <property type="entry name" value="FCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103657">
        <property type="entry name" value="BAR/IMD domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51741">
        <property type="entry name" value="F_BAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="3" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-BAR" evidence="6">
        <location>
            <begin position="18"/>
            <end position="274"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01077"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88060.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="681" mass="79815" checksum="FA2D48085CB44D2D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRV8</accession>
    <name>Q5CRV8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Membrane associated adenyl cyclase with 2 transmembrane regions and an adenylyl cyclase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_1290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88117.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626078.1">
        <property type="nucleotide sequence ID" value="XM_626078.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRV8"/>
    <dbReference type="STRING" id="353152.Q5CRV8"/>
    <dbReference type="GeneID" id="3373296"/>
    <dbReference type="KEGG" id="cpv:cgd5_1290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1290"/>
    <dbReference type="InParanoid" id="Q5CRV8"/>
    <dbReference type="OMA" id="IQIRERM"/>
    <dbReference type="OrthoDB" id="10265730at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006171">
        <property type="term" value="P:cAMP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035556">
        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07302">
        <property type="entry name" value="CHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1230">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001054">
        <property type="entry name" value="A/G_cyclase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050697">
        <property type="entry name" value="Adenylyl/Guanylyl_Cyclase_3/4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029787">
        <property type="entry name" value="Nucleotide_cyclase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081:SF1">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43081">
        <property type="entry name" value="ADENYLATE CYCLASE, TERMINAL-DIFFERENTIATION SPECIFIC-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00044">
        <property type="entry name" value="CYCc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55073">
        <property type="entry name" value="Nucleotide cyclase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50125">
        <property type="entry name" value="GUANYLATE_CYCLASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="14"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="126"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="167"/>
            <end position="183"/>
        </location>
    </feature>
    <feature type="domain" description="Guanylate cyclase" evidence="2">
        <location>
            <begin position="282"/>
            <end position="414"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88117.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="546" mass="63079" checksum="C479D1BA463073CF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRW2</accession>
    <name>Q5CRW2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Dymeclin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_1250</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the dymeclin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88120.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626074.1">
        <property type="nucleotide sequence ID" value="XM_626074.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRW2"/>
    <dbReference type="GeneID" id="3373062"/>
    <dbReference type="KEGG" id="cpv:cgd5_1250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1250"/>
    <dbReference type="InParanoid" id="Q5CRW2"/>
    <dbReference type="OMA" id="QEMINID"/>
    <dbReference type="OrthoDB" id="10253409at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007030">
        <property type="term" value="P:Golgi organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019142">
        <property type="entry name" value="Dymeclin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12895:SF9">
        <property type="entry name" value="DYMECLIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09742">
        <property type="entry name" value="Dymeclin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0519">Myristate</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="112"/>
            <end position="130"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00015736"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88120.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="772" mass="90310" checksum="42E521DB5F1B5271" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRW7</accession>
    <name>Q5CRW7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Ring finger and bbox containing protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_1200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88125.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626069.1">
        <property type="nucleotide sequence ID" value="XM_626069.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRW7"/>
    <dbReference type="STRING" id="353152.Q5CRW7"/>
    <dbReference type="GeneID" id="3373067"/>
    <dbReference type="KEGG" id="cpv:cgd5_1200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1200"/>
    <dbReference type="InParanoid" id="Q5CRW7"/>
    <dbReference type="OMA" id="INCCITS"/>
    <dbReference type="OrthoDB" id="342941at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd19757">
        <property type="entry name" value="Bbox1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd19756">
        <property type="entry name" value="Bbox2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.160.60">
        <property type="entry name" value="Classic Zinc Finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047153">
        <property type="entry name" value="TRIM45/56/19-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000315">
        <property type="entry name" value="Znf_B-box"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462">
        <property type="entry name" value="BONUS, ISOFORM C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR25462:SF296">
        <property type="entry name" value="MEIOTIC P26, ISOFORM F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00643">
        <property type="entry name" value="zf-B_box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00336">
        <property type="entry name" value="BBOX"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57845">
        <property type="entry name" value="B-box zinc-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50119">
        <property type="entry name" value="ZF_BBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="3">
        <location>
            <begin position="57"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="domain" description="B box-type" evidence="4">
        <location>
            <begin position="132"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="17"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00024"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88125.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="653" mass="74337" checksum="3EED4CFD8A4CBDB0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRX0</accession>
    <name>Q5CRX0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">POZ domain protein that is fused to a MATH domain at its N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_1160</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88126.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626066.1">
        <property type="nucleotide sequence ID" value="XM_626066.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRX0"/>
    <dbReference type="STRING" id="353152.Q5CRX0"/>
    <dbReference type="GeneID" id="3373068"/>
    <dbReference type="KEGG" id="cpv:cgd5_1160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1160"/>
    <dbReference type="InParanoid" id="Q5CRX0"/>
    <dbReference type="OMA" id="YSTHRIR"/>
    <dbReference type="OrthoDB" id="6359816at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030163">
        <property type="term" value="P:protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00121">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.210.10">
        <property type="entry name" value="Apoptosis, Tumor Necrosis Factor Receptor Associated Protein 2, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.710.10">
        <property type="entry name" value="Potassium Channel Kv1.1, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000210">
        <property type="entry name" value="BTB/POZ_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002083">
        <property type="entry name" value="MATH/TRAF_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011333">
        <property type="entry name" value="SKP1/BTB/POZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008974">
        <property type="entry name" value="TRAF-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24413">
        <property type="entry name" value="SPECKLE-TYPE POZ PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00651">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00225">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54695">
        <property type="entry name" value="POZ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49599">
        <property type="entry name" value="TRAF domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50097">
        <property type="entry name" value="BTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50144">
        <property type="entry name" value="MATH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MATH" evidence="2">
        <location>
            <begin position="15"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="BTB" evidence="1">
        <location>
            <begin position="268"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50097"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50144"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88126.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="429" mass="48774" checksum="5A29EE71B8E0B130" modified="2005-04-12" version="1">MPVINCSSTRLRTDLIDYIWTIEDFPLLRTLAMQRALPNHDRIISKKFGDQHNGTWFLTIFPAGVNCDGDMLSIYLFSYSEQIRIAQFEISLLDDKLNIIEGTTVSLSQPRIFNVHDSSWGWEDYMRIDIIDDTSLNDMSIKNSPSQAIPSPFGNDLGRTLSPDELIYFSDEGLDTYSVQNHLLDGSSEIKSSEDNILNWERTVLKYFIFGGAIRVKINIKSFKDFIHSDGSVMVPNFLSNRIATQDYLWLANDISKLSKECSDKLCEKVTLNCGTELFHVPKFALAARSKYFQNFFLSNFSDSNAKYFSIPVGDASPYILRNALDYILTGDCRLLSDENIKNWKEIIDLFRFSDKYGIKSLYNACVPAIIANINSESVWATMIIAKQCNSDKILKSVEHFFKTSGDFSLIVNALVGHILEYKNSIVKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRY8</accession>
    <name>Q5CRY8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L13A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_970</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88252.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626048.1">
        <property type="nucleotide sequence ID" value="XM_626048.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRY8"/>
    <dbReference type="FunCoup" id="Q5CRY8">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRY8"/>
    <dbReference type="GeneID" id="3373299"/>
    <dbReference type="KEGG" id="cpv:cgd5_970"/>
    <dbReference type="InParanoid" id="Q5CRY8"/>
    <dbReference type="OMA" id="TRFNKTH"/>
    <dbReference type="OrthoDB" id="1882297at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0017148">
        <property type="term" value="P:negative regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00392">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1180.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3250">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1180.10">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01366">
        <property type="entry name" value="Ribosomal_uL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005822">
        <property type="entry name" value="Ribosomal_uL13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005755">
        <property type="entry name" value="Ribosomal_uL13_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036899">
        <property type="entry name" value="Ribosomal_uL13_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01077">
        <property type="entry name" value="L13_A_E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545:SF3">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11545">
        <property type="entry name" value="RIBOSOMAL PROTEIN L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00572">
        <property type="entry name" value="Ribosomal_L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52161">
        <property type="entry name" value="Ribosomal protein L13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88252.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="204" mass="22984" checksum="78BAD042102AA1FB" modified="2005-04-12" version="1" fragment="single">QKMMKEKIVIDCRGSLLGRLASVIAKELLNGQKIVAVRCEGINISGSLYRNRMKYQDFLRKRMNTNPRKGPFHHRAPSKILFRAVRGMIPHKTPRGAAALARLTTIDGCPAPFDKVKRVVVPSSLRVLRLKPQRKYTTLGTLSSLVGYNKCKTISALEEKRKERSHAFFVKKVAKDKALRAAQKSVFSKLSTEEQTILRLAGQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="116" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRZ1</accession>
    <name>Q5CRZ1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H2A</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd5_940</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H2A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88144.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626045.1">
        <property type="nucleotide sequence ID" value="XM_626045.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRZ1"/>
    <dbReference type="FunCoup" id="Q5CRZ1">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRZ1"/>
    <dbReference type="GeneID" id="3373131"/>
    <dbReference type="KEGG" id="cpv:cgd5_940"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_940"/>
    <dbReference type="InParanoid" id="Q5CRZ1"/>
    <dbReference type="OMA" id="MNKKGAP"/>
    <dbReference type="OrthoDB" id="9421954at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00074">
        <property type="entry name" value="HFD_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000005">
        <property type="entry name" value="Histone H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002119">
        <property type="entry name" value="Histone_H2A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032454">
        <property type="entry name" value="Histone_H2A_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032458">
        <property type="entry name" value="Histone_H2A_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23430">
        <property type="entry name" value="HISTONE H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16211">
        <property type="entry name" value="Histone_H2A_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00620">
        <property type="entry name" value="HISTONEH2A"/>
    </dbReference>
    <dbReference type="SMART" id="SM00414">
        <property type="entry name" value="H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00046">
        <property type="entry name" value="HISTONE_H2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 8" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5 8" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="30"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="Histone H2A C-terminal" evidence="11">
        <location>
            <begin position="112"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="42"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="9">
        <location>
            <begin position="9"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU003767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF16211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK88144.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="152" mass="15682" checksum="DFA0B355D7DA4E75" modified="2005-04-12" version="1">MDGATSSGKIGGKVGGKVGGKGKAGSGKGSKKQPTSRAARAGLQFPVGRIQRMLKHRIPGDCRVGSTASVYAAAILEYLTAEVLELAGNASKDLKVKRITPRHLQLAIRGDEELDSLIKATIAGGGVIPHIEKSLMGKALIGKKGKKGNMSP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS43</accession>
    <name>Q5CS43_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Putative polyphosphate synthetase VTC4, 3 transmembrane domains at C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_310</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88182.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625993.1">
        <property type="nucleotide sequence ID" value="XM_625993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS43"/>
    <dbReference type="STRING" id="353152.Q5CS43"/>
    <dbReference type="GeneID" id="3373189"/>
    <dbReference type="KEGG" id="cpv:cgd5_310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_310"/>
    <dbReference type="InParanoid" id="Q5CS43"/>
    <dbReference type="OMA" id="KIHHEEW"/>
    <dbReference type="OrthoDB" id="6493944at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006799">
        <property type="term" value="P:polyphosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd07751">
        <property type="entry name" value="PolyPPase_VTC4_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.100.30">
        <property type="entry name" value="VTC, catalytic tunnel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004331">
        <property type="entry name" value="SPX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051572">
        <property type="entry name" value="VTC_Complex_Subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018966">
        <property type="entry name" value="VTC_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042267">
        <property type="entry name" value="VTC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46140:SF1">
        <property type="entry name" value="VACUOLAR TRANSPORTER CHAPERONE COMPLEX SUBUNIT 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09359">
        <property type="entry name" value="VTC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51382">
        <property type="entry name" value="SPX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="711"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="741"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="793"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="domain" description="SPX" evidence="7">
        <location>
            <begin position="1"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88182.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="813" mass="95790" checksum="36F3D0E0CE0847E4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSF1</accession>
    <name>Q5CSF1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L27</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_3000</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88556.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628116.1">
        <property type="nucleotide sequence ID" value="XM_628116.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSF1"/>
    <dbReference type="FunCoup" id="Q5CSF1">
        <property type="interactions" value="370"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSF1"/>
    <dbReference type="GeneID" id="3371344"/>
    <dbReference type="KEGG" id="cpv:cgd1_3000"/>
    <dbReference type="InParanoid" id="Q5CSF1"/>
    <dbReference type="OMA" id="NQWFFTK"/>
    <dbReference type="OrthoDB" id="2365484at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06090">
        <property type="entry name" value="KOW_RPL27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.770">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001141">
        <property type="entry name" value="Ribosomal_eL27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041991">
        <property type="entry name" value="Ribosomal_eL27_KOW"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038655">
        <property type="entry name" value="Ribosomal_eL27_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10497">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01777">
        <property type="entry name" value="Ribosomal_L27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009124"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88556.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="162" mass="18549" checksum="47D39062A3FE2EC1" modified="2005-04-12" version="1" fragment="single">FFRLIFSEFKLGRNLLKMAKLMKQGRVVVLLNGRYAGKKAVVVNTFESGTKDRPFPFVLVAGVEKAPLKVHKRLSKEKLKKKSTIKPFLKSINMNHVMPTRYVVSDFDIKPLLQGIDMQEADGKKQALRALHLAFNDKLINIQSEKGKAPKDLIFLRKPLRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSF9</accession>
    <name>Q5CSF9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta transducin ortholog with WD40 repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_2890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628108.1">
        <property type="nucleotide sequence ID" value="XM_628108.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSF9"/>
    <dbReference type="FunCoup" id="Q5CSF9">
        <property type="interactions" value="423"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSF9"/>
    <dbReference type="GeneID" id="3371717"/>
    <dbReference type="KEGG" id="cpv:cgd1_2890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2890"/>
    <dbReference type="InParanoid" id="Q5CSF9"/>
    <dbReference type="OMA" id="CIYAWRA"/>
    <dbReference type="OrthoDB" id="10250769at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034388">
        <property type="term" value="C:Pwp2p-containing subcomplex of 90S preribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019775">
        <property type="entry name" value="WD40_repeat_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059157">
        <property type="entry name" value="WDR36-Utp21_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007319">
        <property type="entry name" value="WDR36/Utp21_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22840:SF12">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 36"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25171">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25168">
        <property type="entry name" value="Beta-prop_WDR36-Utp21_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04192">
        <property type="entry name" value="Utp21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00678">
        <property type="entry name" value="WD_REPEATS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1 3" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="WDR36/Utp21 N-terminal" evidence="6">
        <location>
            <begin position="35"/>
            <end position="316"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="3">
        <location>
            <begin position="239"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="domain" description="WDR36/Utp21 C-terminal" evidence="5">
        <location>
            <begin position="765"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="732"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="740"/>
            <end position="750"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="Pfam" id="PF04192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF25171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="981" mass="111249" checksum="4FF328AEE9E26315" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSJ6</accession>
    <name>Q5CSJ6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Threonylcarbamoyl-AMP synthase</fullName>
            <ecNumber evidence="3">2.7.7.87</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">L-threonylcarbamoyladenylate synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd1_2420</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>L-threonine + hydrogencarbonate + ATP = L-threonylcarbamoyladenylate + diphosphate + H2O</text>
            <dbReference type="Rhea" id="RHEA:36407"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:17544"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:73682"/>
            <dbReference type="EC" id="2.7.7.87"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SUA5 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.87" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628071.1">
        <property type="nucleotide sequence ID" value="XM_628071.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSJ6"/>
    <dbReference type="STRING" id="353152.Q5CSJ6"/>
    <dbReference type="GeneID" id="3371352"/>
    <dbReference type="KEGG" id="cpv:cgd1_2420"/>
    <dbReference type="InParanoid" id="Q5CSJ6"/>
    <dbReference type="OMA" id="MITHYAP"/>
    <dbReference type="OrthoDB" id="412787at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003725">
        <property type="term" value="F:double-stranded RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061710">
        <property type="term" value="F:L-threonylcarbamoyladenylate synthase"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008033">
        <property type="term" value="P:tRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.870.10">
        <property type="entry name" value="DHBP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11030">
        <property type="entry name" value="Threonylcarbamoyl-AMP synthase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017945">
        <property type="entry name" value="DHBP_synth_RibB-like_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006070">
        <property type="entry name" value="Sua5-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038385">
        <property type="entry name" value="Sua5/YwlC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005145">
        <property type="entry name" value="Sua5_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010923">
        <property type="entry name" value="T(6)A37_SUA5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050156">
        <property type="entry name" value="TC-AMP_synthase_SUA5"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00057">
        <property type="entry name" value="L-threonylcarbamoyladenylate synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490">
        <property type="entry name" value="SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17490:SF16">
        <property type="entry name" value="THREONYLCARBAMOYL-AMP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03481">
        <property type="entry name" value="Sua5_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01300">
        <property type="entry name" value="Sua5_yciO_yrdC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF004930">
        <property type="entry name" value="Tln_factor_SUA5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55821">
        <property type="entry name" value="YrdC/RibB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51163">
        <property type="entry name" value="YRDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 13" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="YrdC-like" evidence="14">
        <location>
            <begin position="2"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="24"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="47"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="51"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="56"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="113"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="133"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="135"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="143"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="181"/>
        </location>
        <ligand>
            <name>L-threonine</name>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="197"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="13">
        <location>
            <position position="257"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00015492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00029774"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048366"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR004930-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK88564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="390" mass="44373" checksum="2950D8543343AA6E" modified="2005-04-12" version="1" fragment="single">YMSNLSDYAKYILNGELVAIPTETVYGLGGNAYDRSSILKIFKIKGRPINNPLICHVHSFKFAEDNVFELSERTRVIYKILTDKFWPGPLTVISKKRHNIVDEVSVSGKVGVRCPNNQLTLDLLKLSSVPIAAPSANRSGHISPTTPLHVSKEFDQSYMNEVGIKVWILDGGECCSVGVESTVLEYYEDGNFISIFRCGKVTKKQIWETLIDNCRNNEWIKEIKISYFGSNNSSPNRNYLSLHDTVAISPGMDIKHYSPTICTKLISFISDTNKYTGINVDLRNIILIDIGSKLSFLRCYVRHYFSLCDDYDFSLACKNLFATLHQAEDFANSLDDLSSVYIFITGFETEDNISLALWDRVYRASSGELIYCNLNEIKIQHKYIKRFYKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSP0</accession>
    <name>Q5CSP0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1880</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88409.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628027.1">
        <property type="nucleotide sequence ID" value="XM_628027.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSP0"/>
    <dbReference type="GeneID" id="3371660"/>
    <dbReference type="KEGG" id="cpv:cgd1_1880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1880"/>
    <dbReference type="InParanoid" id="Q5CSP0"/>
    <dbReference type="OMA" id="SENTPHY"/>
    <dbReference type="OrthoDB" id="343784at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="22"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88409.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="203" mass="23788" checksum="E9794B565DF3A3F0" modified="2005-04-12" version="1">MKNLNSCIDENGKTPHFYYQRSVILEQELKELKLKYIKIQNESNRNKEILQNQIEKLVAINRKQESLLFEFEQYRQICRTGIAIICRFCGSIIENEAVMQHLVDIHLFESIENKSSSLESNQIFLMNQLEIENKFDSIGSKCFELITQDANEVDKIDIDISMPNKNNILIKITGFNEDKDDMLICSTDSLFKLRIQVIYIIIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSP9</accession>
    <name>Q5CSP9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_1780</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628018.1">
        <property type="nucleotide sequence ID" value="XM_628018.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSP9"/>
    <dbReference type="GeneID" id="3371630"/>
    <dbReference type="KEGG" id="cpv:cgd1_1780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1780"/>
    <dbReference type="InParanoid" id="Q5CSP9"/>
    <dbReference type="OMA" id="HKICNTH"/>
    <dbReference type="OrthoDB" id="337047at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="460" mass="53388" checksum="499D214B49368E86" modified="2005-04-12" version="1">MCGFDLVGIILTVKWPYQEPEIIFYHPPSSFSILNEKNVIQTKECFGHECSKLAPLILPSDSALWNKMSDLVIESKDFQHRFVFFPSSTIHTKSLNQALFNNNQKKINIDNRNLELDKFIESFSVTLVFIASTLINYEFIEEKLFRITSTLLSCEIANNFISVEILRSNETSFEYLKNLYKSFQNNKGGASIGSEHINLSGSERSNLQEHIFSIVEKNNRLSKKLIKYFTRLKIDCNDFTVTPSKPHHFFSSIDNNCLQNPVESLYDKLTFYIDKSKLSNIYKENELINEISNIADPHLSIRDISVELLEQPSNILKVCQKLITKKVAKVLEIIRYDKVYVICPDSIKTQVNRFNLKYKDIIDWKGCNPLILISSFFCNGKKLCDVRSELVEFFQKFTREKRASEHLIYYPYESSDKIYSSNRDEALKTVKSIISWLYVNGCIEVKYSIDAPNDNIDLFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT11</accession>
    <name>Q5CT11_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_480</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88515.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627906.1">
        <property type="nucleotide sequence ID" value="XM_627906.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT11"/>
    <dbReference type="GeneID" id="3371415"/>
    <dbReference type="KEGG" id="cpv:cgd1_480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_480"/>
    <dbReference type="InParanoid" id="Q5CT11"/>
    <dbReference type="OrthoDB" id="341526at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88515.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="165" mass="19387" checksum="7EB77AC856636BFE" modified="2005-04-12" version="1">MFNLIIKFQIITNKNTNFSLIIKYLPTRIDNNQIILFELFKQVYEDILCLISCIPNNIVKETEINKLSELNFKIMVHKNIEKDSKIFKAFNYSSISYDPKSSICQSTRYSPYQYKDIIFKINSLTLSSSSHETISLFMENQLTCVKIVSLKLKQKYHTLTSIPFF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT34</accession>
    <name>Q5CT34_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycosylphosphatidylinositol transamidase, involved in GPI anchor biosynthesis</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_220</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase C13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88527.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627883.1">
        <property type="nucleotide sequence ID" value="XM_627883.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT34"/>
    <dbReference type="FunCoup" id="Q5CT34">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT34"/>
    <dbReference type="GeneID" id="3371427"/>
    <dbReference type="KEGG" id="cpv:cgd1_220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_220"/>
    <dbReference type="InParanoid" id="Q5CT34"/>
    <dbReference type="OMA" id="TTILCYR"/>
    <dbReference type="OrthoDB" id="192611at2759"/>
    <dbReference type="UniPathway" id="UPA00196"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042765">
        <property type="term" value="C:GPI-anchor transamidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003923">
        <property type="term" value="F:GPI-anchor transamidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016255">
        <property type="term" value="P:attachment of GPI anchor to protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006506">
        <property type="term" value="P:GPI anchor biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1460">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028361">
        <property type="entry name" value="GPI_transamidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001096">
        <property type="entry name" value="Peptidase_C13"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48067:SF1">
        <property type="entry name" value="GPI-ANCHOR TRANSAMIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01650">
        <property type="entry name" value="Peptidase_C13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00776">
        <property type="entry name" value="HEMOGLOBNASE"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0337">GPI-anchor biosynthesis</keyword>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0732">Signal</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="6"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="403"/>
            <end position="424"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009941"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022502"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88527.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="426" mass="49636" checksum="6B6500418D183BAD" modified="2005-04-12" version="1">MKIFSAFTILLFYSLEILFQGLLTRTKTFEYSFLQLKSQNNWAVIVSTSRYWYNYRHNTNALSFYNYLRQNGFRDDRIILMLAENIPCNTRNSIPGGVYSEDFDFFYNLNNHTQTMECADVDYREDEVTVSNFIKVLTNKHDDSVPNKKRLLSDEDSNIFIFLTGHGGDGFLKFQDFEEMTSFELANAIKEMKAHKRFKKMFIISETCQASTLHNHLDFEDVYAIGCSSLGESSYSKHYKVEIGVASIDRFTHFSLADFKNLNRNKLMPIASLIGKYSVFQLKSTPQLKYKPGKTDIKNVYVNEFFFPNIEKLFSLNIGNLILNHKNIKEPIKQVLNEGASKYLNCSLLYHTLKRYNDLDLIDSLSNCHFKNTLKKAIIFSQKRYVFNSKFSSKKMIDNKSLMLIKAIFGLTFILILVFILSYYSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTC1</accession>
    <name>Q5CTC1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">2x WD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626548.1">
        <property type="nucleotide sequence ID" value="XM_626548.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTC1"/>
    <dbReference type="STRING" id="353152.Q5CTC1"/>
    <dbReference type="GeneID" id="3373695"/>
    <dbReference type="KEGG" id="cpv:cgd2_3610"/>
    <dbReference type="InParanoid" id="Q5CTC1"/>
    <dbReference type="OMA" id="HMSHINI"/>
    <dbReference type="OrthoDB" id="20669at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0080008">
        <property type="term" value="C:Cul4-RING E3 ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071493">
        <property type="term" value="P:cellular response to UV-B"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046377">
        <property type="entry name" value="DHU1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47201">
        <property type="entry name" value="BNAC09G30780D PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47201:SF1">
        <property type="entry name" value="PROTEIN DWD HYPERSENSITIVE TO UV-B 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="362"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="425" mass="48427" checksum="91CFF99C18B17F76" modified="2005-04-12" version="1" fragment="single">LRFFEKTKNSKLTETFFFPLKTLLGISLSPIIGLSWFNCHPQTFVAGSCLLGTISILSYKENPFYQPIDYLQDQNNNFQSNRKVDQDKQEDKFPYLFNTENKSKPFPQLSSLSVNATDDYYLASGFGKSVGLYDTNTGSQVKILPSMHMSHINIVRFANYHPQIFSTASFDSSCKLWDLRQKINGNNPIIKFELPCMAIMSCFSPKDDLKMVISGVDDYLKQLDLRLKETNHGNGGRGFNIPTLRDSQSYRRSVYNSNGDLVLSINTKDKYVRIFDTESLSPKLKFGYFHMLSSQYEEGYKRKSPTRSYPVVHTFTESNVNRNEVIHSNTRIEREIEGEVDSTSSSQITQIEETSVAEGNNIRIHQTSINEEENELDNEKKDYSLLSVRGHPIYADVGGFLISESTGNSKLALLKFGKILNNELK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTH3</accession>
    <name>Q5CTH3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_3020</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88712.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626496.1">
        <property type="nucleotide sequence ID" value="XM_626496.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTH3"/>
    <dbReference type="GeneID" id="3373456"/>
    <dbReference type="KEGG" id="cpv:cgd2_3020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3020"/>
    <dbReference type="InParanoid" id="Q5CTH3"/>
    <dbReference type="OMA" id="WSILITD"/>
    <dbReference type="OrthoDB" id="340403at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039924">
        <property type="entry name" value="ICln/Lot5/Saf5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03517">
        <property type="entry name" value="Voldacs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88712.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="175" mass="20044" checksum="548D2531CB5F42BA" modified="2005-04-12" version="1">MTIFEVKLSSATTLQDLLGENEYVKDNYKNCDILVLDYEGKEKLGFLNRDILLTDYRLIFLKDAEYSTQNSKIPSKFSCGDYINISSIIVNAVSSCEKAEDNPYLYVQLGDPEFNEDSDEDLESSHRFSEINIRCSDQNTIYTLFNSISETAAYMEQLENLSDLKSDDELTTDQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="99" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTH7</accession>
    <name>Q5CTH7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">E3 ubiquitin-protein ligase listerin</fullName>
            <ecNumber evidence="5">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd2_2950</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the LTN1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="5"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88716.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626492.1">
        <property type="nucleotide sequence ID" value="XM_626492.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTH7"/>
    <dbReference type="GeneID" id="3373460"/>
    <dbReference type="KEGG" id="cpv:cgd2_2950"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2950"/>
    <dbReference type="InParanoid" id="Q5CTH7"/>
    <dbReference type="OMA" id="NICESNT"/>
    <dbReference type="OrthoDB" id="6108at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990112">
        <property type="term" value="C:RQC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043023">
        <property type="term" value="F:ribosomal large subunit binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072344">
        <property type="term" value="P:rescue of stalled ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990116">
        <property type="term" value="P:ribosome-associated ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16491">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000038">
        <property type="entry name" value="E3 ubiquitin-protein ligase listerin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039795">
        <property type="entry name" value="LTN1/Rkr1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054476">
        <property type="entry name" value="Ltn1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054478">
        <property type="entry name" value="LTN1_UBC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039804">
        <property type="entry name" value="RING-CH-C4HC3_LTN1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389:SF0">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE LISTERIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12389">
        <property type="entry name" value="ZINC FINGER PROTEIN 294"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22958">
        <property type="entry name" value="Ltn1_1st"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23009">
        <property type="entry name" value="UBC_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="10" id="KW-0677">Repeat</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="12" id="KW-0833">Ubl conjugation pathway</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="11 14" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="15">
        <location>
            <begin position="2111"/>
            <end position="2157"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00007997"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK88716.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2162" mass="248771" checksum="40AC674D4E5DCCFC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTI4</accession>
    <name>Q5CTI4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">40S ribosomal protein S28, no good start Met</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_2870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eS28 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626485.1">
        <property type="nucleotide sequence ID" value="XM_626485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTI4"/>
    <dbReference type="FunCoup" id="Q5CTI4">
        <property type="interactions" value="307"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTI4"/>
    <dbReference type="GeneID" id="3373701"/>
    <dbReference type="KEGG" id="cpv:cgd2_2870"/>
    <dbReference type="InParanoid" id="Q5CTI4"/>
    <dbReference type="OMA" id="NTGMHGE"/>
    <dbReference type="OrthoDB" id="10258930at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022627">
        <property type="term" value="C:cytosolic small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000028">
        <property type="term" value="P:ribosomal small subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04457">
        <property type="entry name" value="S1_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000180">
        <property type="entry name" value="40S ribosomal protein S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00292">
        <property type="entry name" value="Ribosomal_eS28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000289">
        <property type="entry name" value="Ribosomal_eS28"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028626">
        <property type="entry name" value="Ribosomal_eS28_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10769:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN ES28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01200">
        <property type="entry name" value="Ribosomal_S28e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00961">
        <property type="entry name" value="RIBOSOMAL_S28E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="68" mass="7500" checksum="50C0F3D444D2D9DF" modified="2005-04-12" version="1" fragment="single">DSAPKLAKVEKILGRTGSRGGVIQVRVQFMSGESELAGRSLIRNVRGPVREGDILALLETEREARRLR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTL1</accession>
    <name>Q5CTL1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_2560</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626458.1">
        <property type="nucleotide sequence ID" value="XM_626458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTL1"/>
    <dbReference type="GeneID" id="3373644"/>
    <dbReference type="KEGG" id="cpv:cgd2_2560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2560"/>
    <dbReference type="InParanoid" id="Q5CTL1"/>
    <dbReference type="OrthoDB" id="343974at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254388" evidence="2">
        <location>
            <begin position="27"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="387"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="486"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="601"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="717"/>
            <end position="740"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="1">
        <location>
            <begin position="521"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="626"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="722"/>
            <end position="737"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="753" mass="83751" checksum="6F1FF8DF912BBA78" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTP2</accession>
    <name>Q5CTP2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_2220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88774.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626427.1">
        <property type="nucleotide sequence ID" value="XM_626427.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTP2"/>
    <dbReference type="GeneID" id="3373518"/>
    <dbReference type="KEGG" id="cpv:cgd2_2220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2220"/>
    <dbReference type="InParanoid" id="Q5CTP2"/>
    <dbReference type="OrthoDB" id="338183at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="26"/>
            <end position="36"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88774.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="284" mass="32897" checksum="B1B67C03B80ADD71" modified="2005-04-12" version="1">MNKTISSDNLKDAVRKWHAKRKKDSNNQANSENTGSEPEGIFGTKKHDVRHISAWSHNNFVESNQLSHFTNEQKRPRPTVIENNIKYIFDGPLSFDTIMALKRKKSNVIFSNNEKILNNPNIEQNDSKSAINQCYTHQTNNSQVMDNFKDEINIIYSKSISAVQNFFKISSMSEVINLLEYILNFLSFSTQELISRYNKKAYFDRHEKSLGICINFILNKSNLTDEQFDETSLEYLAKYPKVFESLKTLTKINGLNDTVPSEISNHIQKLNSQIDKIYNLLLNR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTY9</accession>
    <name>Q5CTY9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Queuine tRNA-guanine transglycosylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_990</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88856.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626330.1">
        <property type="nucleotide sequence ID" value="XM_626330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTY9"/>
    <dbReference type="STRING" id="353152.Q5CTY9"/>
    <dbReference type="GeneID" id="3373599"/>
    <dbReference type="KEGG" id="cpv:cgd2_990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_990"/>
    <dbReference type="InParanoid" id="Q5CTY9"/>
    <dbReference type="OMA" id="MELPINS"/>
    <dbReference type="OrthoDB" id="27601at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.105">
        <property type="entry name" value="Queuine tRNA-ribosyltransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050852">
        <property type="entry name" value="Queuine_tRNA-ribosyltrfase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036511">
        <property type="entry name" value="TGT-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002616">
        <property type="entry name" value="tRNA_ribo_trans-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46064:SF1">
        <property type="entry name" value="QUEUINE TRNA-RIBOSYLTRANSFERASE ACCESSORY SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01702">
        <property type="entry name" value="TGT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51713">
        <property type="entry name" value="tRNA-guanine transglycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="tRNA-guanine(15) transglycosylase-like" evidence="1">
        <location>
            <begin position="384"/>
            <end position="601"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF01702"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88856.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="632" mass="70848" checksum="9963B8EBEA8C7F67" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU81</accession>
    <name>Q5CU81_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_3870</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89241.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626933.1">
        <property type="nucleotide sequence ID" value="XM_626933.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU81"/>
    <dbReference type="FunCoup" id="Q5CU81">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373926"/>
    <dbReference type="KEGG" id="cpv:cgd3_3870"/>
    <dbReference type="InParanoid" id="Q5CU81"/>
    <dbReference type="OMA" id="CGNINCI"/>
    <dbReference type="OrthoDB" id="408098at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89241.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="202" mass="23359" checksum="9C593A429388F1E1" modified="2005-04-12" version="1" fragment="single">SDCFVNMFRCRICTEPPFSHFFNLRIFNGYFSDERSKKTPYQLSEGDSVYDTQSYGSSLLATPSNLNSFEPRSSEEINSICLKWEKCVHERGREFWRTSECLMEVLSAIARGVNNNDDPILGDPQRCIMWYGQVSAIDGCPVIRMKRPDEVVETHTYVNRALVFLYASDESFEELQLKPRVAFNMACGNRRCVHLRHISLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUG0</accession>
    <name>Q5CUG0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_2970</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89035.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626854.1">
        <property type="nucleotide sequence ID" value="XM_626854.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUG0"/>
    <dbReference type="GeneID" id="3374099"/>
    <dbReference type="KEGG" id="cpv:cgd3_2970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2970"/>
    <dbReference type="InParanoid" id="Q5CUG0"/>
    <dbReference type="OMA" id="ANTWIIL"/>
    <dbReference type="OrthoDB" id="343193at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="CDD" id="cd20805">
        <property type="entry name" value="C1_DGK_rpt2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89035.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1210" mass="140333" checksum="AB5D90377874ED66" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUG9</accession>
    <name>Q5CUG9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative acyl-CoA synthetases</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_2870</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the ATP-dependent AMP-binding enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89041.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626845.1">
        <property type="nucleotide sequence ID" value="XM_626845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUG9"/>
    <dbReference type="STRING" id="353152.Q5CUG9"/>
    <dbReference type="GeneID" id="3374105"/>
    <dbReference type="KEGG" id="cpv:cgd3_2870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2870"/>
    <dbReference type="InParanoid" id="Q5CUG9"/>
    <dbReference type="OMA" id="HEDSCCV"/>
    <dbReference type="OrthoDB" id="2962993at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031956">
        <property type="term" value="F:medium-chain fatty acid-CoA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006631">
        <property type="term" value="P:fatty acid metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.980">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.38.10">
        <property type="entry name" value="Luciferase, Domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020845">
        <property type="entry name" value="AMP-binding_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000873">
        <property type="entry name" value="AMP-dep_synth/lig_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201">
        <property type="entry name" value="ACYL-COA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43201:SF5">
        <property type="entry name" value="MEDIUM-CHAIN ACYL-COA LIGASE ACSF2, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00501">
        <property type="entry name" value="AMP-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56801">
        <property type="entry name" value="Acetyl-CoA synthetase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00455">
        <property type="entry name" value="AMP_BINDING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AMP-dependent synthetase/ligase" evidence="3">
        <location>
            <begin position="297"/>
            <end position="555"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006432"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00501"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89041.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="777" mass="89779" checksum="8F313F111F25ED82" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUI6</accession>
    <name>Q5CUI6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Signal peptidase complex subunit 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_2680</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SPCS3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89261.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626828.1">
        <property type="nucleotide sequence ID" value="XM_626828.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUI6"/>
    <dbReference type="FunCoup" id="Q5CUI6">
        <property type="interactions" value="154"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUI6"/>
    <dbReference type="GeneID" id="3373776"/>
    <dbReference type="KEGG" id="cpv:cgd3_2680"/>
    <dbReference type="InParanoid" id="Q5CUI6"/>
    <dbReference type="OMA" id="FWDDGHG"/>
    <dbReference type="OrthoDB" id="10261524at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005787">
        <property type="term" value="C:signal peptidase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045047">
        <property type="term" value="P:protein targeting to ER"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007653">
        <property type="entry name" value="SPC3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804">
        <property type="entry name" value="MICROSOMAL SIGNAL PEPTIDASE 23 KD SUBUNIT SPC22/23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12804:SF0">
        <property type="entry name" value="SIGNAL PEPTIDASE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04573">
        <property type="entry name" value="SPC22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="9"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004648"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009289"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00029556"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89261.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="203" mass="23586" checksum="2A7F849E992E505E" modified="2005-04-12" version="1" fragment="single">INLRLEKTYFITNLLLIIPRLCNSFHIFIKMDSLFSRINIIFCSFVISLACCAVGNFASSFIYKELPIGDTELHSILDLGISPYLRNDQANIALNINTNLSNSLNWNTNQIFTFIYVSYKNKHQNNYVTVWDDIFSKKKNKTSFSMKGVINKYPIRDIGRNLRSKSINLNIAFCYMPIVGSIKYHHLKVSTEKKLPVNYFQYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUL1</accession>
    <name>Q5CUL1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Yn1201cp-family protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_2400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89298.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626803.1">
        <property type="nucleotide sequence ID" value="XM_626803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUL1"/>
    <dbReference type="STRING" id="353152.Q5CUL1"/>
    <dbReference type="GeneID" id="3374063"/>
    <dbReference type="KEGG" id="cpv:cgd3_2400"/>
    <dbReference type="InParanoid" id="Q5CUL1"/>
    <dbReference type="OMA" id="ALMTHNN"/>
    <dbReference type="OrthoDB" id="27483at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030289">
        <property type="term" value="C:protein phosphatase 4 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072542">
        <property type="term" value="F:protein phosphatase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006887">
        <property type="entry name" value="P4R3-like_central_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051137">
        <property type="entry name" value="PP4R3-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318">
        <property type="entry name" value="ATP SYNTHASE GAMMA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23318:SF0">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04802">
        <property type="entry name" value="PP4R3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine-protein phosphatase 4 regulatory subunit 3-like central" evidence="3">
        <location>
            <begin position="151"/>
            <end position="687"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04802"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89298.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="832" mass="97567" checksum="EA30C66444D8D39C" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUV4</accession>
    <name>Q5CUV4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">UB domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1350</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89150.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626710.1">
        <property type="nucleotide sequence ID" value="XM_626710.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUV4"/>
    <dbReference type="STRING" id="353152.Q5CUV4"/>
    <dbReference type="GeneID" id="3373983"/>
    <dbReference type="KEGG" id="cpv:cgd3_1350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1350"/>
    <dbReference type="InParanoid" id="Q5CUV4"/>
    <dbReference type="OMA" id="NIRDSWI"/>
    <dbReference type="OrthoDB" id="419317at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071818">
        <property type="term" value="C:BAT3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051787">
        <property type="term" value="F:misfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031593">
        <property type="term" value="F:polyubiquitin modification-dependent protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15204:SF0">
        <property type="entry name" value="LARGE PROLINE-RICH PROTEIN BAG6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00213">
        <property type="entry name" value="UBQ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="2">
        <location>
            <begin position="89"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="36"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="287"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="408"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="537"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="600"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="926"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="287"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="311"/>
            <end position="334"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="339"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="442"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="554"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="617"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="934"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89150.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1023" mass="110645" checksum="05BB190C37019042" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUZ1</accession>
    <name>Q5CUZ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">DnaJ domain, possible zf-CSL following</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DPH4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89290.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626673.1">
        <property type="nucleotide sequence ID" value="XM_626673.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUZ1"/>
    <dbReference type="FunCoup" id="Q5CUZ1">
        <property type="interactions" value="35"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUZ1"/>
    <dbReference type="GeneID" id="3373844"/>
    <dbReference type="KEGG" id="cpv:cgd3_930"/>
    <dbReference type="InParanoid" id="Q5CUZ1"/>
    <dbReference type="OMA" id="LEDMTWE"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008198">
        <property type="term" value="F:ferrous iron binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.660.10">
        <property type="entry name" value="DPH Zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007872">
        <property type="entry name" value="DPH_MB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036671">
        <property type="entry name" value="DPH_MB_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45255">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45255:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 24"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05207">
        <property type="entry name" value="Zn_ribbon_CSL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144217">
        <property type="entry name" value="CSL zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51074">
        <property type="entry name" value="DPH_MB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0408">Iron</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="J" evidence="5">
        <location>
            <begin position="16"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="domain" description="DPH-type MB" evidence="6">
        <location>
            <begin position="113"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006169"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51074"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89290.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="170" mass="19928" checksum="103BDC0274ADC5C9" modified="2005-04-12" version="1" fragment="single">FVQRLEMASNWEDSLNPYSLLGVKRDASERDIRLAFLRLVRKFHPDKNISELNQEKDTQIANNGEQGDHNSRITVKYHALYDAYCILKDPEKRKEYDLSAFNESLSNYNSMIWHKSVNLEELEYMDEDGKEVFAYFCRCGGLIFLEKKHIEEGYNLFSCDGCSSKIMITF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV33</accession>
    <name>Q5CV33_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Glutathione peroxidase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_460</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 4">Belongs to the glutathione peroxidase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89216.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626631.1">
        <property type="nucleotide sequence ID" value="XM_626631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV33"/>
    <dbReference type="FunCoup" id="Q5CV33">
        <property type="interactions" value="109"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV33"/>
    <dbReference type="GeneID" id="3373805"/>
    <dbReference type="KEGG" id="cpv:cgd3_460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_460"/>
    <dbReference type="InParanoid" id="Q5CV33"/>
    <dbReference type="OMA" id="TFPMTEK"/>
    <dbReference type="OrthoDB" id="446890at2759"/>
    <dbReference type="BRENDA" id="1.11.1.9">
        <property type="organism ID" value="1728"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004601">
        <property type="term" value="F:peroxidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034599">
        <property type="term" value="P:cellular response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00340">
        <property type="entry name" value="GSH_Peroxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000889">
        <property type="entry name" value="Glutathione_peroxidase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029759">
        <property type="entry name" value="GPX_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11592:SF78">
        <property type="entry name" value="GLUTATHIONE PEROXIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00255">
        <property type="entry name" value="GSHPx"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01011">
        <property type="entry name" value="GLUTPROXDASE"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00460">
        <property type="entry name" value="GLUTATHIONE_PEROXID_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51355">
        <property type="entry name" value="GLUTATHIONE_PEROXID_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51352">
        <property type="entry name" value="THIOREDOXIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 4" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="2 4 7" id="KW-0575">Peroxidase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Thioredoxin" evidence="6">
        <location>
            <begin position="13"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="195"/>
            <end position="218"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006926"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022559"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="RuleBase" id="RU000499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89216.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="218" mass="24747" checksum="E6C6E8FEED3DF73C" modified="2005-04-12" version="1">MGNFLASTKITTDLASKSVYSYTLTTLEGNPFPMESLKGKVVMVTNVASKCGYTKSYYKQMVRIYSVFAPLGLEIIGLPSREFMGQEFEDPKEIRKFADSHNVKFPLMEICKVNGPDALEFVQKLKRETPELYDEKSNTLSAIKWNFSRFLIDKNGKVVAFRGTRTEPNELIPKIAELLGVSDYQNLFKNYDKLHPESGYDPKDDVCPLKQKQSEQGS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV39</accession>
    <name>Q5CV39_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_400</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626625.1">
        <property type="nucleotide sequence ID" value="XM_626625.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV39"/>
    <dbReference type="GeneID" id="3373996"/>
    <dbReference type="KEGG" id="cpv:cgd3_400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_400"/>
    <dbReference type="InParanoid" id="Q5CV39"/>
    <dbReference type="OrthoDB" id="341050at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="911" mass="106876" checksum="2980333F54AC80C2" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV66</accession>
    <name>Q5CV66_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Protein with 2x PHD domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_5250</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89646.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627403.1">
        <property type="nucleotide sequence ID" value="XM_627403.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV66"/>
    <dbReference type="STRING" id="353152.Q5CV66"/>
    <dbReference type="GeneID" id="3374224"/>
    <dbReference type="KEGG" id="cpv:cgd8_5250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5250"/>
    <dbReference type="InParanoid" id="Q5CV66"/>
    <dbReference type="OMA" id="RICINCR"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.1150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888">
        <property type="entry name" value="HL01030P-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45888:SF4">
        <property type="entry name" value="PHD FINGER PROTEIN 10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="7" id="KW-0804">Transcription</keyword>
    <keyword evidence="6" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 9" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="11">
        <location>
            <begin position="200"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="71"/>
            <end position="109"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89646.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="336" mass="39062" checksum="69509EA73739C655" modified="2005-04-12" version="1">MQDNLEIFRNKYHIRCRYTKLTYCTCTKGNKNFYYTGDHELKSMFEKILPSSQIHELLKLLADSNEARIGLRSSTQKYKRIERIVAREREEFNIRYEKEKKRIRELNSEKMSDIVVSKNSECSEDSEQTALLEDVDKQGSGNELDESTATQCCAEECSDKENYENILRCNVCHKSFHTWCCSPKMSEYIKNSFPWACSECISCTVCKRSDRPSIQVFCDICSRCFHTSCLNPKLHKVPRNFWLCDDCKVCSKCHKLINFPVENGEILSESLPEGFDYLDSKYGTRICYECKEDEKDLICGVCNCALYKSGNRVCSLCKMYVHNNCLNAQICNLCNQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV99</accession>
    <name>Q5CV99_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_4860</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89619.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627370.1">
        <property type="nucleotide sequence ID" value="XM_627370.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV99"/>
    <dbReference type="GeneID" id="3374375"/>
    <dbReference type="KEGG" id="cpv:cgd8_4860"/>
    <dbReference type="InParanoid" id="Q5CV99"/>
    <dbReference type="OrthoDB" id="343124at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254991" evidence="2">
        <location>
            <begin position="34"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="306"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="307"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="344"/>
            <end position="361"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="362"/>
            <end position="371"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89619.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="535" mass="60884" checksum="62B0C8BE6924D597" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVC2</accession>
    <name>Q5CVC2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ISWI related chromatinic protein with an apicomplexan specific domain architecture composed of 3x PHD+SNF2 ATpase+2xPHD</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd8_4620</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89597.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627347.1">
        <property type="nucleotide sequence ID" value="XM_627347.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVC2"/>
    <dbReference type="GeneID" id="3374446"/>
    <dbReference type="KEGG" id="cpv:cgd8_4620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4620"/>
    <dbReference type="InParanoid" id="Q5CVC2"/>
    <dbReference type="OMA" id="VCKPEEH"/>
    <dbReference type="OrthoDB" id="448448at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd17919">
        <property type="entry name" value="DEXHc_Snf"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd15489">
        <property type="entry name" value="PHD_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019786">
        <property type="entry name" value="Zinc_finger_PHD-type_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10799">
        <property type="entry name" value="SNF2/RAD54 HELICASE FAMILY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 5" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="9"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="9">
        <location>
            <begin position="12"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="61"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="8">
        <location>
            <begin position="141"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="10">
        <location>
            <begin position="368"/>
            <end position="534"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="11">
        <location>
            <begin position="917"/>
            <end position="1083"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="256"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="554"/>
            <end position="573"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="764"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1184"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1298"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1342"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="2068"/>
            <end position="2140"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="1495"/>
            <end position="1522"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="259"/>
            <end position="273"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="285"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="300"/>
            <end position="312"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="313"/>
            <end position="322"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="554"/>
            <end position="563"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="764"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="791"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1196"/>
            <end position="1213"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1222"/>
            <end position="1242"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1267"/>
            <end position="1282"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1307"/>
            <end position="1321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="1342"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="1362"/>
            <end position="1380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="2068"/>
            <end position="2078"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2079"/>
            <end position="2091"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="2116"/>
            <end position="2125"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="7">
        <location>
            <begin position="2130"/>
            <end position="2140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89597.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2140" mass="236335" checksum="B876439580365817" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVV4</accession>
    <name>Q5CVV4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_2650</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89452.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627165.1">
        <property type="nucleotide sequence ID" value="XM_627165.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVV4"/>
    <dbReference type="GeneID" id="3374381"/>
    <dbReference type="KEGG" id="cpv:cgd8_2650"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2650"/>
    <dbReference type="InParanoid" id="Q5CVV4"/>
    <dbReference type="OMA" id="RCNISER"/>
    <dbReference type="OrthoDB" id="341202at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264:SF3">
        <property type="entry name" value="F-BOX DOMAIN-CONTAINING PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1486"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2566"/>
            <end position="2609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1489"/>
            <end position="1499"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1500"/>
            <end position="1554"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1555"/>
            <end position="1627"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="2566"/>
            <end position="2580"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="2585"/>
            <end position="2599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89452.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="3488" mass="387652" checksum="3A5216328C7DD9E6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVX9</accession>
    <name>Q5CVX9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">diacylglycerol kinase (ATP)</fullName>
            <ecNumber evidence="2">2.7.1.107</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_2390</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic diacylglycerol kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.1.107" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89430.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627140.1">
        <property type="nucleotide sequence ID" value="XM_627140.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVX9"/>
    <dbReference type="STRING" id="353152.Q5CVX9"/>
    <dbReference type="GeneID" id="3374461"/>
    <dbReference type="KEGG" id="cpv:cgd8_2390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2390"/>
    <dbReference type="InParanoid" id="Q5CVX9"/>
    <dbReference type="OrthoDB" id="242257at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004143">
        <property type="term" value="F:ATP-dependent diacylglycerol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007200">
        <property type="term" value="P:phospholipase C-activating G protein-coupled receptor signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037607">
        <property type="entry name" value="DGK"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000756">
        <property type="entry name" value="Diacylglycerol_kin_accessory"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001206">
        <property type="entry name" value="Diacylglycerol_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255">
        <property type="entry name" value="DIACYLGLYCEROL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11255:SF121">
        <property type="entry name" value="DIACYLGLYCEROL KINASE (ATP)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00609">
        <property type="entry name" value="DAGK_acc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00781">
        <property type="entry name" value="DAGK_cat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50146">
        <property type="entry name" value="DAGK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="DAGKc" evidence="8">
        <location>
            <begin position="114"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="404"/>
            <end position="428"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="406"/>
            <end position="419"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012133"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89430.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="616" mass="69832" checksum="54C88D74E3F95852" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW01</accession>
    <name>Q5CW01_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">DNA sliding clamp PCNA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd8_2150</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processivity during elongation of the leading strand.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the PCNA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627118.1">
        <property type="nucleotide sequence ID" value="XM_627118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW01"/>
    <dbReference type="FunCoup" id="Q5CW01">
        <property type="interactions" value="491"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW01"/>
    <dbReference type="GeneID" id="3374557"/>
    <dbReference type="KEGG" id="cpv:cgd8_2150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2150"/>
    <dbReference type="InParanoid" id="Q5CW01"/>
    <dbReference type="OMA" id="EMKLINM"/>
    <dbReference type="OrthoDB" id="534348at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043626">
        <property type="term" value="C:PCNA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030337">
        <property type="term" value="F:DNA polymerase processivity factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006272">
        <property type="term" value="P:leading strand elongation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006275">
        <property type="term" value="P:regulation of DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019985">
        <property type="term" value="P:translesion synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00577">
        <property type="entry name" value="PCNA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.10.150.10:FF:000006">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.70.10.10:FF:000001">
        <property type="entry name" value="Proliferating cell nuclear antigen"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.150.10">
        <property type="entry name" value="DNA Polymerase III, subunit A, domain 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00317">
        <property type="entry name" value="DNApol_clamp_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046938">
        <property type="entry name" value="DNA_clamp_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000730">
        <property type="entry name" value="Pr_cel_nuc_antig"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022649">
        <property type="entry name" value="Pr_cel_nuc_antig_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022659">
        <property type="entry name" value="Pr_cel_nuc_antig_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022648">
        <property type="entry name" value="Pr_cel_nuc_antig_N"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00590">
        <property type="entry name" value="pcna"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11352:SF0">
        <property type="entry name" value="PROLIFERATING CELL NUCLEAR ANTIGEN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02747">
        <property type="entry name" value="PCNA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00705">
        <property type="entry name" value="PCNA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00339">
        <property type="entry name" value="PCNACYCLIN"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55979">
        <property type="entry name" value="DNA clamp"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01251">
        <property type="entry name" value="PCNA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0235">DNA replication</keyword>
    <keyword evidence="4 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA N-terminal" evidence="8">
        <location>
            <begin position="1"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="domain" description="Proliferating cell nuclear antigen PCNA C-terminal" evidence="9">
        <location>
            <begin position="128"/>
            <end position="254"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010462"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000641"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF00705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02747"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="262" mass="29210" checksum="00FF6FAC28939CB6" modified="2005-04-12" version="1">MFEARLSNGGILRKVFEAITNLVSDVNLECNESGVTIQAMDNSHVSLVGLYLKDTAFERYRCDKNRTLGLNTQNVVKLLKLCSNDDQVLLRHDDDSESLIFIFETPNGDRVSEFELTLISIDQDSLQIPETSFSSVVTMPSNEFQRLCRDMAQFSDSLSIDVTSKNVRFSTKGSLGSGSIILRPKEGADSEAVALDVSEPCQLVFSLRYLNNFAKATPLSNSVKLSMSENQPLELEYPLEGSGSGHLRFYLARKITEDDEQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW43</accession>
    <name>Q5CW43_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">NAD dependent dehydrogenase of possible bacterial origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_1700</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89684.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627076.1">
        <property type="nucleotide sequence ID" value="XM_627076.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW43"/>
    <dbReference type="STRING" id="353152.Q5CW43"/>
    <dbReference type="GeneID" id="3374406"/>
    <dbReference type="KEGG" id="cpv:cgd8_1700"/>
    <dbReference type="InParanoid" id="Q5CW43"/>
    <dbReference type="OMA" id="GGHCMDI"/>
    <dbReference type="OrthoDB" id="339764at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004022">
        <property type="term" value="F:alcohol dehydrogenase (NAD+) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1970">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1090.10">
        <property type="entry name" value="Dehydroquinate synthase-like - alpha domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001670">
        <property type="entry name" value="ADH_Fe/GldA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056798">
        <property type="entry name" value="ADH_Fe_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039697">
        <property type="entry name" value="Alcohol_dehydrogenase_Fe"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496">
        <property type="entry name" value="ALCOHOL DEHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11496:SF83">
        <property type="entry name" value="HYDROXYACID-OXOACID TRANSHYDROGENASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25137">
        <property type="entry name" value="ADH_Fe_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00465">
        <property type="entry name" value="Fe-ADH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56796">
        <property type="entry name" value="Dehydroquinate synthase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0560">Oxidoreductase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Alcohol dehydrogenase iron-type/glycerol dehydrogenase GldA" evidence="2">
        <location>
            <begin position="19"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Fe-containing alcohol dehydrogenase-like C-terminal" evidence="3">
        <location>
            <begin position="209"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF25137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89684.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="480" mass="52608" checksum="40481A4512CF5EF4" modified="2005-04-12" version="1" fragment="single">ILINIVVKIKKMLILTPIIYYNMDSFRDIISDLLDSNVGRAILVFSSAVKCQAMRVESMVKKNGIQIEFSELCESDANALSTILLQMKSYKPDCIIGMGGGHCMDIAKVLRVLYEDPNTTLRSLAMGTNNNDKEKSSKKAMIHRRGSLIKKLVCIPTTCGSGSEVTSTAVLRNDDGRQMIVSGVAFLPDISVIDSSFILTIPMFVASITGMRALLHGLESYISNSSNHYSSCMAIQSLRILFNSLTKAVIEKDISLLQEIHKAASISGVAISATDVGLGTILSRSISEVFTLPHGLIDSIVITQVLNFNIKKSQTVGPLIANLSVELGISNPEDSNSNKIQALLNRIDEIKKTLLLPDSLSSIHSSLSNFKSKGWFDPIGVKLSVFSQCIEIDNQEFINHVSGSFSISDKETRAYVTEENALRTIPILSKKSVIDNLNFNTLQMNLDRMISRALSDEAIHTNPATVTKEDLSTILKETWG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWA9</accession>
    <name>Q5CWA9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_1020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89326.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627010.1">
        <property type="nucleotide sequence ID" value="XM_627010.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWA9"/>
    <dbReference type="GeneID" id="3374435"/>
    <dbReference type="KEGG" id="cpv:cgd8_1020"/>
    <dbReference type="InParanoid" id="Q5CWA9"/>
    <dbReference type="OrthoDB" id="10071381at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.580">
        <property type="entry name" value="Structural maintenance of chromosome 1. Chain E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006909">
        <property type="entry name" value="Rad21/Rec8_C_eu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023093">
        <property type="entry name" value="ScpA-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04824">
        <property type="entry name" value="Rad21_Rec8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rad21/Rec8-like protein C-terminal eukaryotic" evidence="3">
        <location>
            <begin position="406"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="359"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="4"/>
            <end position="31"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="361"/>
            <end position="372"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF04824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89326.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="458" mass="52333" checksum="A44FB2A52FCC9B21" modified="2005-04-12" version="1">MFQGEESEELLEQLERKKLNAERSKLSDRDKENQFMEETTEIVCEAQNRGENRKRSRCLSHLDVDLKFKGISSINKNQLEMLVFNDEIIAGMDERLRGWDSYKWWQTETQKNEKSQFLIKFQSLAIRSMKKSKRISVSNQNGSNLDMYEAIEKHRGEYDTGVEYSNVDLGFDHFNLDNGFVGSPSNRFRNGRDTIESSVNYYGDGANSSGGARLQSGRESMIFSDSRRGSNDGVRLSTMLETGSVLSYNSSPFQFEKNLMGIRRDSSNSELQRIVRSGRLSGSIVGNSYDKQYRTNSIATSISDIFCMEEIKSSNWSKSGITTSSGTYNLKTYTVQKFIATRMKEIREIRKINEENGYLMDNNTSNKENIGSHNREEENSGTFNKKKDNRNVESDDNEEEMSIYLSELLPEKTATKCTAAVFFYHLLVLATYNEIKLTQSTPGGNIKITKTSSFNEES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWC0</accession>
    <name>Q5CWC0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar membrane protein pep3</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_910</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626999.1">
        <property type="nucleotide sequence ID" value="XM_626999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWC0"/>
    <dbReference type="STRING" id="353152.Q5CWC0"/>
    <dbReference type="GeneID" id="3374419"/>
    <dbReference type="KEGG" id="cpv:cgd8_910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_910"/>
    <dbReference type="InParanoid" id="Q5CWC0"/>
    <dbReference type="OMA" id="WIQREKW"/>
    <dbReference type="OrthoDB" id="1845386at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005768">
        <property type="term" value="C:endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030897">
        <property type="term" value="C:HOPS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030674">
        <property type="term" value="F:protein-macromolecule adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007032">
        <property type="term" value="P:endosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048284">
        <property type="term" value="P:organelle fusion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007033">
        <property type="term" value="P:vacuole organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006904">
        <property type="term" value="P:vesicle docking involved in exocytosis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007810">
        <property type="entry name" value="Pep3/Vps18_beta-prop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23323:SF26">
        <property type="entry name" value="VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05131">
        <property type="entry name" value="Pep3_Vps18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Pep3/Vps18 beta-propeller" evidence="4">
        <location>
            <begin position="117"/>
            <end position="383"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF05131"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1248" mass="143279" checksum="D7F75E1266AE1B08" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWC4</accession>
    <name>Q5CWC4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA polymerase alpha subunit B</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_870</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA polymerase alpha subunit B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89315.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626995.1">
        <property type="nucleotide sequence ID" value="XM_626995.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWC4"/>
    <dbReference type="FunCoup" id="Q5CWC4">
        <property type="interactions" value="190"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWC4"/>
    <dbReference type="GeneID" id="3374416"/>
    <dbReference type="KEGG" id="cpv:cgd8_870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_870"/>
    <dbReference type="InParanoid" id="Q5CWC4"/>
    <dbReference type="OMA" id="CRPSEMK"/>
    <dbReference type="OrthoDB" id="336885at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005658">
        <property type="term" value="C:alpha DNA polymerase:primase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007185">
        <property type="entry name" value="DNA_pol_a/d/e_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016722">
        <property type="entry name" value="DNA_pol_alpha_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054300">
        <property type="entry name" value="OB_DPOA2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061">
        <property type="entry name" value="DNA POLYMERASE 2 ALPHA 70 KDA SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23061:SF12">
        <property type="entry name" value="DNA POLYMERASE ALPHA SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04042">
        <property type="entry name" value="DNA_pol_E_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22062">
        <property type="entry name" value="OB_DPOA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0235">DNA replication</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA polymerase alpha subunit B OB" evidence="7">
        <location>
            <begin position="224"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="domain" description="DNA polymerase alpha/delta/epsilon subunit B" evidence="6">
        <location>
            <begin position="336"/>
            <end position="550"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007299"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018596"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF04042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF22062"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89315.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="621" mass="69903" checksum="6867F62C9D80A815" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWD8</accession>
    <name>Q5CWD8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Myosin heavy chain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_710</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="6">Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89304.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626981.1">
        <property type="nucleotide sequence ID" value="XM_626981.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CWD8"/>
    <dbReference type="STRING" id="353152.Q5CWD8"/>
    <dbReference type="GeneID" id="3374518"/>
    <dbReference type="KEGG" id="cpv:cgd8_710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_710"/>
    <dbReference type="InParanoid" id="Q5CWD8"/>
    <dbReference type="OMA" id="NGSTICM"/>
    <dbReference type="OrthoDB" id="312459at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016459">
        <property type="term" value="C:myosin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051015">
        <property type="term" value="F:actin filament binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000146">
        <property type="term" value="F:microfilament motor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00124">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.4820">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.530">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.850.10">
        <property type="entry name" value="Kinesin motor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.720">
        <property type="entry name" value="Myosin VI head, motor domain, U50 subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036961">
        <property type="entry name" value="Kinesin_motor_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001609">
        <property type="entry name" value="Myosin_head_motor_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140:SF706">
        <property type="entry name" value="DILUTE CLASS UNCONVENTIONAL MYOSIN, ISOFORM C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13140">
        <property type="entry name" value="MYOSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00063">
        <property type="entry name" value="Myosin_head"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00193">
        <property type="entry name" value="MYOSINHEAVY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00242">
        <property type="entry name" value="MYSc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51456">
        <property type="entry name" value="MYOSIN_MOTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="2 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 6" id="KW-0505">Motor protein</keyword>
    <keyword evidence="3 6" id="KW-0518">Myosin</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myosin motor" evidence="8">
        <location>
            <begin position="64"/>
            <end position="832"/>
        </location>
    </feature>
    <feature type="region of interest" description="Actin-binding" evidence="6">
        <location>
            <begin position="711"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="980"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="7">
        <location>
            <begin position="982"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="1009"/>
            <end position="1019"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <begin position="158"/>
            <end position="165"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00782"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51456"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89304.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1827" mass="210085" checksum="ACB882FAA1D15328" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWE0</accession>
    <name>Q5CWE0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Signal peptide containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626979.1">
        <property type="nucleotide sequence ID" value="XM_626979.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWE0"/>
    <dbReference type="STRING" id="353152.Q5CWE0"/>
    <dbReference type="GeneID" id="3374489"/>
    <dbReference type="KEGG" id="cpv:cgd8_690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_690"/>
    <dbReference type="InParanoid" id="Q5CWE0"/>
    <dbReference type="OrthoDB" id="344268at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253919" description="Signal peptide containing protein" evidence="2">
        <location>
            <begin position="21"/>
            <end position="648"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="67"/>
            <end position="94"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="150"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="648" mass="76734" checksum="6AE7EBF6BFB8DD92" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWF1</accession>
    <name>Q5CWF1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_5340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90103.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627853.1">
        <property type="nucleotide sequence ID" value="XM_627853.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWF1"/>
    <dbReference type="GeneID" id="3375848"/>
    <dbReference type="KEGG" id="cpv:cgd6_5340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5340"/>
    <dbReference type="InParanoid" id="Q5CWF1"/>
    <dbReference type="OMA" id="RCHHSEN"/>
    <dbReference type="OrthoDB" id="337552at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254576" evidence="2">
        <location>
            <begin position="21"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="533"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="537"/>
            <end position="554"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90103.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="565" mass="63522" checksum="237E02520BB7BD69" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWH0</accession>
    <name>Q5CWH0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Protein with two PHD Zn fingers that is probably involved in chromatin function</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_5120</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90177.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627834.1">
        <property type="nucleotide sequence ID" value="XM_627834.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWH0"/>
    <dbReference type="STRING" id="353152.Q5CWH0"/>
    <dbReference type="GeneID" id="3375922"/>
    <dbReference type="KEGG" id="cpv:cgd6_5120"/>
    <dbReference type="InParanoid" id="Q5CWH0"/>
    <dbReference type="OMA" id="WIHIECA"/>
    <dbReference type="OrthoDB" id="336088at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050701">
        <property type="entry name" value="Histone_Mod_Regulator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793:SF107">
        <property type="entry name" value="BROMODOMAIN-CONTAINING PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13793">
        <property type="entry name" value="PHD FINGER PROTEINS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13771">
        <property type="entry name" value="zf-HC5HC2H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="PHD-type" evidence="5">
        <location>
            <begin position="11"/>
            <end position="67"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90177.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="228" mass="27151" checksum="42D8FCC692EA98F2" modified="2005-04-12" version="1" fragment="single">LYFIYCYMLNDRECIICNDVEEYAYNELTLVKCKNCDVFFHKICYGISNHNASSQGIVILCDPCQYELQIKGKQLNKLSSNKDLKCLICFNTGILKRVLIPQKFDLFQTSESKFNHLQNRAIWIHIECAIYSQDYITIHNWRTMSNIEILKPLIYINNKSCCFCNGNFGILRKCRFSQCMEYFHIHCLLKSPHYKRRNIKIEKNHLFEIYCHKHFKIQSQISLEQGQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWI6</accession>
    <name>Q5CWI6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Beta-adaptin AP complex subunit-related ARM/HEAT repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_4930</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endomembrane system</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the adaptor complexes large subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90071.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627818.1">
        <property type="nucleotide sequence ID" value="XM_627818.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWI6"/>
    <dbReference type="FunCoup" id="Q5CWI6">
        <property type="interactions" value="175"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWI6"/>
    <dbReference type="GeneID" id="3375816"/>
    <dbReference type="KEGG" id="cpv:cgd6_4930"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4930"/>
    <dbReference type="InParanoid" id="Q5CWI6"/>
    <dbReference type="OMA" id="ANCMHAL"/>
    <dbReference type="OrthoDB" id="10254310at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030117">
        <property type="term" value="C:membrane coat"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006886">
        <property type="term" value="P:intracellular protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026739">
        <property type="entry name" value="AP_beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002553">
        <property type="entry name" value="Clathrin/coatomer_adapt-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11134">
        <property type="entry name" value="ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01602">
        <property type="entry name" value="Adaptin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0653">Protein transport</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="domain" description="Clathrin/coatomer adaptor adaptin-like N-terminal" evidence="6">
        <location>
            <begin position="46"/>
            <end position="634"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004308"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF01602"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90071.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="884" mass="103086" checksum="7CC9483E31EFE345" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWK1</accession>
    <name>Q5CWK1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4 13">Tubulin beta chain</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd6_4760</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12 13">Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the tubulin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90185.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627803.1">
        <property type="nucleotide sequence ID" value="XM_627803.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWK1"/>
    <dbReference type="SMR" id="Q5CWK1"/>
    <dbReference type="FunCoup" id="Q5CWK1">
        <property type="interactions" value="104"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWK1"/>
    <dbReference type="GeneID" id="3376001"/>
    <dbReference type="KEGG" id="cpv:cgd6_4760"/>
    <dbReference type="InParanoid" id="Q5CWK1"/>
    <dbReference type="OMA" id="WVPRSVN"/>
    <dbReference type="OrthoDB" id="1662883at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005200">
        <property type="term" value="F:structural constituent of cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007017">
        <property type="term" value="P:microtubule-based process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02187">
        <property type="entry name" value="beta_tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.287.600:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1330.20:FF:000002">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1440:FF:000003">
        <property type="entry name" value="Tubulin beta chain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.600">
        <property type="entry name" value="Helix hairpin bin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1330.20">
        <property type="entry name" value="Tubulin/FtsZ, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1440">
        <property type="entry name" value="Tubulin/FtsZ, GTPase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002453">
        <property type="entry name" value="Beta_tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008280">
        <property type="entry name" value="Tub_FtsZ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000217">
        <property type="entry name" value="Tubulin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037103">
        <property type="entry name" value="Tubulin/FtsZ-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018316">
        <property type="entry name" value="Tubulin/FtsZ_2-layer-sand-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036525">
        <property type="entry name" value="Tubulin/FtsZ_GTPase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023123">
        <property type="entry name" value="Tubulin_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017975">
        <property type="entry name" value="Tubulin_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003008">
        <property type="entry name" value="Tubulin_FtsZ_GTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11588">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00091">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03953">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01163">
        <property type="entry name" value="BETATUBULIN"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01161">
        <property type="entry name" value="TUBULIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00864">
        <property type="entry name" value="Tubulin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00865">
        <property type="entry name" value="Tubulin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55307">
        <property type="entry name" value="Tubulin C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52490">
        <property type="entry name" value="Tubulin nucleotide-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00227">
        <property type="entry name" value="TUBULIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="10 13" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="7" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6 13" id="KW-0493">Microtubule</keyword>
    <keyword evidence="8 13" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Tubulin/FtsZ GTPase" evidence="14">
        <location>
            <begin position="48"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin/FtsZ 2-layer sandwich" evidence="15">
        <location>
            <begin position="247"/>
            <end position="384"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="16">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009636"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00013288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022701"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00034296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00864"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00865"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK90185.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="445" mass="49995" checksum="925620CE8E632E31" modified="2005-04-12" version="1" fragment="single">RMREIVHIQGGQCGNQIGAKFWEVISDEHGIDPTGTYHGESDLQMERINVFYNEASGGRYVPRAILVDLEPGTMDSVRAGPFGSLFRPDNFIFGQSGAGNIWAKGHYTEGAELLDAVMDVVRHEAESCDCLQGFQITHSLGGGTGSGMGTLLVGKIHEEFPDRILQTFSVFPSPKVSDTVVEPYNATLSIHQLVENSDAVQVIDNEALYDICFRTLKLTNPSYGDLNHLVSVAMSGVTCCLRFPGQLNSDLRKMCVNLVPFPRLHFFMIGFAPLTSRGSQQYRSLSVAELTQQMFDAKNMMCASDPRHGRYLTASVMFRGRMSTKEVDEQMLLVQNRNSSYFVEWIPNNIKSSVCDIPPKGLKMASTFVGNSTAIQEMFRRVAEQFTSMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDVPVEEDEYPDDEHHIEA</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWM2</accession>
    <name>Q5CWM2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Telomeric DNA binding protein SANT DNA-binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_4510</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90042.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627782.1">
        <property type="nucleotide sequence ID" value="XM_627782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWM2"/>
    <dbReference type="STRING" id="353152.Q5CWM2"/>
    <dbReference type="GeneID" id="3375787"/>
    <dbReference type="KEGG" id="cpv:cgd6_4510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4510"/>
    <dbReference type="InParanoid" id="Q5CWM2"/>
    <dbReference type="OMA" id="WRVILAN"/>
    <dbReference type="OrthoDB" id="608866at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd11660">
        <property type="entry name" value="SANT_TRF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052450">
        <property type="entry name" value="TRBD-Containing_Protein"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734:SF1">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46734">
        <property type="entry name" value="TELOMERIC REPEAT-BINDING FACTOR 1 TERF1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00249">
        <property type="entry name" value="Myb_DNA-binding"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="1" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="577"/>
            <end position="630"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="4">
        <location>
            <begin position="583"/>
            <end position="634"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="334"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="424"/>
            <end position="457"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="527"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="570"/>
            <end position="579"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90042.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="649" mass="73954" checksum="1A6A9B8F6F79B582" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWM9</accession>
    <name>Q5CWM9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_4440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90040.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627775.1">
        <property type="nucleotide sequence ID" value="XM_627775.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWM9"/>
    <dbReference type="GeneID" id="3375785"/>
    <dbReference type="KEGG" id="cpv:cgd6_4440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4440"/>
    <dbReference type="InParanoid" id="Q5CWM9"/>
    <dbReference type="OMA" id="HSTANDY"/>
    <dbReference type="OrthoDB" id="343451at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="41"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="230"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="230"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90040.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="416" mass="47774" checksum="98F938B0880AE1C5" modified="2007-04-03" version="1">MSEKNIIPFQEEETNNEKKLGVYEKQDLSERRKELWIISKSLGAITLVSAVMNLVLVGIMIFMVNSLIKGIISEHSRQIAIQKGMLSNFIERNSRIEKSVHNERMNFNDHWRKGAGILPLNMLYNAPLKSLENVDAIILEFDEPEQIESGNQEKKIKGKRHQHMYHVESITREVSVEEMEGGKHKKKEEAVLKFNLTNQGTLTVYKDKAILRDRLGNKVHELFFESENQTHEYQSKEAEKLLRSDSKDEENEKQGHIQPNNRKLISSNSHKHSASHSLKTQSGYMAAVCKYGCGEMGVTYPYYYRPFFGYGFPLLGTEPYFQSGYGGNVETAMNNNMFNPESAGPRPPGVQATPQTSPFAMGENPYSYPYSSSPGGGYYYYYNFYPPPPPMQPEPFPYYEESYYNIPQNNTEEEEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWR7</accession>
    <name>Q5CWR7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_4030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90006.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627737.1">
        <property type="nucleotide sequence ID" value="XM_627737.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWR7"/>
    <dbReference type="FunCoup" id="Q5CWR7">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWR7"/>
    <dbReference type="GeneID" id="3375751"/>
    <dbReference type="KEGG" id="cpv:cgd6_4030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4030"/>
    <dbReference type="InParanoid" id="Q5CWR7"/>
    <dbReference type="OMA" id="FMIDIHD"/>
    <dbReference type="OrthoDB" id="361911at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="371"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="621"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="860"/>
            <end position="884"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="984"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="243"/>
            <end position="277"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="55"/>
            <end position="65"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="395"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="621"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="674"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="730"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="731"/>
            <end position="750"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="796"/>
            <end position="814"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="825"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="873"/>
            <end position="883"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90006.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1037" mass="112726" checksum="7D579CED6BE8A0BD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX44</accession>
    <name>Q5CX44_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">MORN domain repeat containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_2570</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell projection</location>
            <location evidence="1">Cilium</location>
            <location evidence="1">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
            <location evidence="2">Cytoskeleton</location>
            <location evidence="2">Cilium axoneme</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89899.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627610.1">
        <property type="nucleotide sequence ID" value="XM_627610.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX44"/>
    <dbReference type="STRING" id="353152.Q5CX44"/>
    <dbReference type="GeneID" id="3376139"/>
    <dbReference type="KEGG" id="cpv:cgd6_2570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2570"/>
    <dbReference type="InParanoid" id="Q5CX44"/>
    <dbReference type="OMA" id="EMYEGYW"/>
    <dbReference type="OrthoDB" id="270720at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005930">
        <property type="term" value="C:axoneme"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.110.10:FF:000002">
        <property type="entry name" value="Phosphatidylinositol 4-phosphate 5-kinase 8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.110.10">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003409">
        <property type="entry name" value="MORN"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46613">
        <property type="entry name" value="RADIAL SPOKE HEAD 10 HOMOLOG B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46613:SF1">
        <property type="entry name" value="RADIAL SPOKE HEAD 10 HOMOLOG B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02493">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SMART" id="SM00698">
        <property type="entry name" value="MORN"/>
        <property type="match status" value="14"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82185">
        <property type="entry name" value="Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0966">Cell projection</keyword>
    <keyword evidence="6" id="KW-0969">Cilium</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="5" id="KW-0282">Flagellum</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004430"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89899.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="365" mass="41306" checksum="DF2EDA32DE69F006" modified="2007-04-03" version="1">METSSHSYSGDIKGGLFHGRGVLIYSKNEKYEGDFVMGKREGFGKFTYADGASYEGEWVDDKIHGQGKASFSSGNTYEGQWENGKINGYGKLTFSNGDVYEGEWVDGKMHGRGVYKYVDGDIYSGEWRDDKRHGKGTVTYVSSTGDQIIEKYEGDWVNGKMHGHGKYVYVDSAVYEGDWFEGSMHGKGTYIFPCGNVYEGEWVNDVKEGYGVLTYQNGEKYEGYWKDGKVNGKGTLTYSRGDKYVGDWLDAKKHGEGELFYSNNDRFKGNWVADKACGFGVYTYANGNRYEGYWENDRRHGKGIFYCAEDNNVYEGEWANGRKDGKGILRFAMGHSIQGVWKDGVLSQFHSLQFPPESQWSNPNF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX74</accession>
    <name>Q5CX74_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Membrane-associated protein with 6 transmembrane domains possible apicomplexan conserved, duplicated adjacent protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89874.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627580.1">
        <property type="nucleotide sequence ID" value="XM_627580.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX74"/>
    <dbReference type="FunCoup" id="Q5CX74">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="GeneID" id="3376172"/>
    <dbReference type="KEGG" id="cpv:cgd6_2220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2220"/>
    <dbReference type="InParanoid" id="Q5CX74"/>
    <dbReference type="OMA" id="MFIFYWA"/>
    <dbReference type="OrthoDB" id="359547at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021691">
        <property type="entry name" value="DUF3273"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11677">
        <property type="entry name" value="DUF3273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="71"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="195"/>
            <end position="217"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="229"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="272"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89874.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="343" mass="38319" checksum="ADA9988EF8A877F8" modified="2007-04-03" version="1">MYSQPYSGEEPMLYQSRGPNKSSTNQFNMSATNGMQVINDGIMDDEALNERGEEITPLISNFSCITLRTGTLLQCASLLVLIILYNVFGNKGLFTFDLYGNGGTLAEDLSYYAGVVSMLCVYFIGVLFLAGFQEFIADNSKAPLGFRAGSRLLNTANIIQIIVVALRVTQFSFTYSYFNQKWYGKFSQTKGDWCLYNFGIVCEAVSLIMYGISFFYVESYADVGVGEQYAYWMLTLFTLAGISELMMLFTGFGSFFILFFAAALIVTCTWAFQFEPLLESNSPLLFSRDINADVLPKETPLDDMSIEKNQTVNNYQPNFTYQLYAGASGVSSVPNPYGVEMQQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXB9</accession>
    <name>Q5CXB9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_1690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89837.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627535.1">
        <property type="nucleotide sequence ID" value="XM_627535.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXB9"/>
    <dbReference type="STRING" id="353152.Q5CXB9"/>
    <dbReference type="GeneID" id="3376116"/>
    <dbReference type="KEGG" id="cpv:cgd6_1690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1690"/>
    <dbReference type="InParanoid" id="Q5CXB9"/>
    <dbReference type="OMA" id="CQNIARE"/>
    <dbReference type="OrthoDB" id="343642at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="775"/>
            <end position="794"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="283"/>
            <end position="317"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="348"/>
            <end position="487"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="531"/>
            <end position="565"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="744"/>
            <end position="771"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89837.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="794" mass="92569" checksum="B6EFAFD7194DC996" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXC6</accession>
    <name>Q5CXC6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">DOT1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89832.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627528.1">
        <property type="nucleotide sequence ID" value="XM_627528.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXC6"/>
    <dbReference type="GeneID" id="3376111"/>
    <dbReference type="KEGG" id="cpv:cgd6_1610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1610"/>
    <dbReference type="InParanoid" id="Q5CXC6"/>
    <dbReference type="OMA" id="FRIMSKY"/>
    <dbReference type="OrthoDB" id="443402at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="366"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="382"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="406"/>
            <end position="418"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89832.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="449" mass="51119" checksum="35016482C7D7B1F0" modified="2007-04-03" version="1">MVGRIPRTKHGENHSSSCPSAENVTINADKKSISNKCCNKIKCSCTSFLWKGVNMDLGTSDEGMYGETREKGLRKIFLKMAKYGMDNTSILLDIGSGRGVPNIVASFQNSLFSSIGIELDEKAFFLSLSNHLHILESRKNSYENSNIENSNISSDFTDSKVNKNNSIGFFKGDATILETFEPVTHIYSFDAAMPIWMIKRFVDLFNASRTTYCYVSFRKDLVETLDIKAKRIHGISTQMMGSGEGRMCWLYLKNDWKEIKEFAWIQICDKYNNGKSCESFDLTNLTDIDKIIRFSICSSSLQMDLINKTLNFWFNNRKSRRECLTERKVINQRHKELKQLYIQEKLIKDDANQLTLEDVGVKIASNTRSNNSNKNTRKNKTDFATKSPECNTKNKNKSYVDGISGNLKNENSSQTQPTIKIMDPSNLSPKKSRAKRKVADAIKRVEITI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXC8</accession>
    <name>Q5CXC8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Eukaryotic translation initiation factor 4 gamma Nic domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd6_1590</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic initiation factor 4G family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90129.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627526.1">
        <property type="nucleotide sequence ID" value="XM_627526.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXC8"/>
    <dbReference type="STRING" id="353152.Q5CXC8"/>
    <dbReference type="GeneID" id="3375874"/>
    <dbReference type="KEGG" id="cpv:cgd6_1590"/>
    <dbReference type="InParanoid" id="Q5CXC8"/>
    <dbReference type="OMA" id="GEYCTAN"/>
    <dbReference type="OrthoDB" id="514777at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016281">
        <property type="term" value="C:eukaryotic translation initiation factor 4F complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.180">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003890">
        <property type="entry name" value="MIF4G-like_typ-3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009818">
        <property type="entry name" value="PAM2_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23253:SF9">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4 GAMMA 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02854">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07145">
        <property type="entry name" value="PAM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00543">
        <property type="entry name" value="MIF4G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MIF4G" evidence="5">
        <location>
            <begin position="702"/>
            <end position="914"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="169"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="256"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="435"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="590"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="936"/>
            <end position="1030"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="169"/>
            <end position="179"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="183"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="224"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="258"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="4">
        <location>
            <begin position="282"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="440"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="457"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="590"/>
            <end position="603"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="639"/>
            <end position="665"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="943"/>
            <end position="952"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="953"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005775"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00543"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90129.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1184" mass="133920" checksum="9C197B971211A682" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXH5</accession>
    <name>Q5CXH5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_1070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the EMC4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89792.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627479.1">
        <property type="nucleotide sequence ID" value="XM_627479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXH5"/>
    <dbReference type="FunCoup" id="Q5CXH5">
        <property type="interactions" value="131"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXH5"/>
    <dbReference type="GeneID" id="3376024"/>
    <dbReference type="KEGG" id="cpv:cgd6_1070"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1070"/>
    <dbReference type="InParanoid" id="Q5CXH5"/>
    <dbReference type="OMA" id="IFMTGFL"/>
    <dbReference type="OrthoDB" id="369569at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009445">
        <property type="entry name" value="TMEM85/Emc4"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19315">
        <property type="entry name" value="ER MEMBRANE PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06417">
        <property type="entry name" value="EMC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="116"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="141"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="182"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="44"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="65"/>
            <end position="79"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007715"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00020820"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89792.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="229" mass="25570" checksum="5268BD4F4A76EC3E" modified="2007-04-03" version="1">MTANQRMRKNEQEETLESDTRSNLGSRYDAWVINPKTIEKKINKSPDKRVLIGSSPCDRTKQDRNSSSSNTNSHCASNSTLNPRIKHQGPTVCAIENAEIQTNQNASEACNFDKKAWSIAHLPLKTMGMTFFMLYMSGNNAGIFSILVVSYALVNAVKILIQANKNFLEIERAARKPFNIQKVVYCLYSLLGIAFILFKLGTMGLIPVNRGDFFSDTPPHAFPLYAIGT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXM4</accession>
    <name>Q5CXM4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627430.1">
        <property type="nucleotide sequence ID" value="XM_627430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXM4"/>
    <dbReference type="GeneID" id="3376042"/>
    <dbReference type="KEGG" id="cpv:cgd6_480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_480"/>
    <dbReference type="InParanoid" id="Q5CXM4"/>
    <dbReference type="OMA" id="FHLECEE"/>
    <dbReference type="OrthoDB" id="343844at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="354"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="354"/>
            <end position="369"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="378"/>
            <end position="389"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="408" mass="47451" checksum="D45A446DEC61C1A6" modified="2005-04-12" version="1">MYREQFQILEDLLKNSQTQQIWSIYSLCNHNSKFENFEICKDILKLFVKYISEEKKDFEGVELVYLVMGDISSNEVAYKLVYDSDLSLNEFEVCKSNIYGLASRKNNENSQENINLKSNSLQFHIECDDIYKSIKAKNSLSEELWNSKFSNIANTKSNLSRESSNVNSVNLDQSEIKSKTEPYPILFSSNKDINQNNKININENENEQEDQWKKNGYLKENENNTDPYPMKNVFDNEKKVILSESNNKKDSDTSMNDNITNLFKDEENENTNSIDEFVQNEDGKCKPTKRRKTSKSKICNDNNDNENKIDFDPLEVEPIMHSKVKKEKMYKDAKTGYLVVEDDVDFVMEKENRITKSREKVSQESEIPSKRSNKTKKSQTSNINSGTSKQQTLNSFFKIVKSTNKNTL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXN8</accession>
    <name>Q5CXN8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Pre-mRNA-splicing factor 18</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_5490</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the PRP18 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90661.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628692.1">
        <property type="nucleotide sequence ID" value="XM_628690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXN8"/>
    <dbReference type="FunCoup" id="Q5CXN8">
        <property type="interactions" value="390"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXN8"/>
    <dbReference type="GeneID" id="3371758"/>
    <dbReference type="KEGG" id="cpv:cgd7_5490"/>
    <dbReference type="InParanoid" id="Q5CXN8"/>
    <dbReference type="OMA" id="SFAQVRW"/>
    <dbReference type="OrthoDB" id="10261918at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071021">
        <property type="term" value="C:U2-type post-spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005682">
        <property type="term" value="C:U5 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000350">
        <property type="term" value="P:generation of catalytic spliceosome for second transesterification step"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.940.10">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.280.110">
        <property type="entry name" value="Pre-mRNA processing factor 4 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004098">
        <property type="entry name" value="Prp18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014906">
        <property type="entry name" value="PRP4-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036285">
        <property type="entry name" value="PRP4-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039979">
        <property type="entry name" value="PRPF18"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007">
        <property type="entry name" value="PRE-MRNA SPLICING FACTOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13007:SF19">
        <property type="entry name" value="PRE-MRNA-SPLICING FACTOR 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02840">
        <property type="entry name" value="Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08799">
        <property type="entry name" value="PRP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00500">
        <property type="entry name" value="SFM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47938">
        <property type="entry name" value="Functional domain of the splicing factor Prp18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158230">
        <property type="entry name" value="PRP4-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Pre-mRNA processing factor 4 (PRP4)-like" evidence="8">
        <location>
            <begin position="95"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008137"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM00500"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90661.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="337" mass="39739" checksum="EC55BC95430D6978" modified="2005-04-12" version="1" fragment="single">PLFFRLHLDNRSWVSQSEVQEHERQEYIRRQRERDLKKVKKENIKNSHCITSEDRIKKSNHENSSSVIDLSNSDCKIISNKLENGSECLTSSLPIQNEETIKRLRLLGEPITLFGEDDNERYNRLRRLEFKGRTNEEMNIGQQNIFLHGFDPNFSLYSVSDDHTQVEIYEEFEHIEGESNQKFILRWIDTQLKEWEKLLKCRKKADSETEKGMQDSAQYYQTKRDIQPLVNSLEASDGKVDKEVLDKLFEIVTLCNQRDYNKAQDKYIELAIGNAPWPMGVTMVGIHERAGRTKIFSSHIAHVLNDETTRKYIQMFKRLVTHCESKRPSREQQKKSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXR4</accession>
    <name>Q5CXR4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 5">D-aminoacyl-tRNA deacylase</fullName>
            <ecNumber evidence="2 5">3.1.1.96</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_5230</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="4">
            <text>a D-aminoacyl-tRNA + H2O = a tRNA + a D-alpha-amino acid + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13953"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:10124"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59871"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:79333"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>glycyl-tRNA(Ala) + H2O = tRNA(Ala) + glycine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:53744"/>
            <dbReference type="Rhea" id="RHEA-COMP:9657"/>
            <dbReference type="Rhea" id="RHEA-COMP:13640"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57305"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78522"/>
            <dbReference type="EC" id="3.1.1.96"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the DTD family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.96" evidence="2 5"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90656.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628666.1">
        <property type="nucleotide sequence ID" value="XM_628664.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXR4"/>
    <dbReference type="FunCoup" id="Q5CXR4">
        <property type="interactions" value="133"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXR4"/>
    <dbReference type="GeneID" id="3371753"/>
    <dbReference type="KEGG" id="cpv:cgd7_5230"/>
    <dbReference type="InParanoid" id="Q5CXR4"/>
    <dbReference type="OMA" id="VFGADMK"/>
    <dbReference type="OrthoDB" id="275783at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051500">
        <property type="term" value="F:D-tyrosyl-tRNA(Tyr) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0106026">
        <property type="term" value="F:Gly-tRNA(Ala) deacylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.50.80.10:FF:000001">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.50.80.10">
        <property type="entry name" value="D-tyrosyl-tRNA(Tyr) deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00518">
        <property type="entry name" value="Deacylase_Dtd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003732">
        <property type="entry name" value="Daa-tRNA_deacyls_DTD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023509">
        <property type="entry name" value="DTD-like_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00256">
        <property type="entry name" value="D-aminoacyl-tRNA deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472:SF5">
        <property type="entry name" value="D-AMINOACYL-TRNA DEACYLASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10472">
        <property type="entry name" value="D-TYROSYL-TRNA TYR DEACYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02580">
        <property type="entry name" value="Tyr_Deacylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69500">
        <property type="entry name" value="DTD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0820">tRNA-binding</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009673"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00013056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00047676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00048018"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003470"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90656.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="178" mass="19520" checksum="1703BF09AF901EC9" modified="2005-04-12" version="1" fragment="single">LILIDLKFSPLRMKVVLQKVKGASVKVDGQIVSSIGPGLLLLVGIRTDDVDSNSDYLVRKCLSIRLWPDESDPTSSKPWKLSVKDKDLEVLVVSQFTLFGNVKNGSKPDFHNAMSGKDALVIFNNMVEKFKKSHDPEKIKTGCFGEEMEVSLVNDGPVTLILENNSKNDAGSDKSSIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXX3</accession>
    <name>Q5CXX3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">U6 snRNA-associated Sm-like protein LSm5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="primary">LSM5</name>
        <name evidence="12" type="ORF">cgd7_4580</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="14" key="2">
        <citation type="journal article" date="2007" name="Mol. Biochem. Parasitol." volume="151" first="100" last="110">
            <title>Genome-scale protein expression and structural biology of Plasmodium falciparum and related Apicomplexan organisms.</title>
            <authorList>
                <person name="Vedadi M."/>
                <person name="Lew J."/>
                <person name="Artz J."/>
                <person name="Amani M."/>
                <person name="Zhao Y."/>
                <person name="Dong A."/>
                <person name="Wasney G.A."/>
                <person name="Gao M."/>
                <person name="Hills T."/>
                <person name="Brokx S."/>
                <person name="Qiu W."/>
                <person name="Sharma S."/>
                <person name="Diassiti A."/>
                <person name="Alam Z."/>
                <person name="Melone M."/>
                <person name="Mulichak A."/>
                <person name="Wernimont A."/>
                <person name="Bray J."/>
                <person name="Loppnau P."/>
                <person name="Plotnikova O."/>
                <person name="Newberry K."/>
                <person name="Sundararajan E."/>
                <person name="Houston S."/>
                <person name="Walker J."/>
                <person name="Tempel W."/>
                <person name="Bochkarev A."/>
                <person name="Kozieradzki I."/>
                <person name="Edwards A."/>
                <person name="Arrowsmith C."/>
                <person name="Roos D."/>
                <person name="Kain K."/>
                <person name="Hui R."/>
            </authorList>
            <dbReference type="PubMed" id="17125854"/>
            <dbReference type="DOI" id="10.1016/j.molbiopara.2006.10.011"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.14 ANGSTROMS)</scope>
    </reference>
    <comment type="function">
        <text evidence="9">Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">LSm subunits form a heteromer with a doughnut shape.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90645.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628607.1">
        <property type="nucleotide sequence ID" value="XM_628605.1"/>
    </dbReference>
    <dbReference type="PDB" id="3PGG">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.14 A"/>
        <property type="chains" value="A/B=1-121"/>
    </dbReference>
    <dbReference type="PDBsum" id="3PGG"/>
    <dbReference type="AlphaFoldDB" id="Q5CXX3"/>
    <dbReference type="SMR" id="Q5CXX3"/>
    <dbReference type="FunCoup" id="Q5CXX3">
        <property type="interactions" value="343"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXX3"/>
    <dbReference type="GeneID" id="3371948"/>
    <dbReference type="KEGG" id="cpv:cgd7_4580"/>
    <dbReference type="InParanoid" id="Q5CXX3"/>
    <dbReference type="OMA" id="YETTPQG"/>
    <dbReference type="OrthoDB" id="429711at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CXX3"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005681">
        <property type="term" value="C:spliceosomal complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01732">
        <property type="entry name" value="LSm5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033871">
        <property type="entry name" value="LSm5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20971:SF0">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="14" id="KW-0002">3D-structure</keyword>
    <keyword evidence="3 9" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6 9" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7 9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 9" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4 9" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="11">
        <location>
            <begin position="28"/>
            <end position="115"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="10">
        <location>
            <begin position="7"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365055"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK90645.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="14">
        <source>
            <dbReference type="PDB" id="3PGG"/>
        </source>
    </evidence>
    <sequence length="121" mass="13286" checksum="16AC102938FD7DD9" modified="2005-04-12" version="1" fragment="single">SYKVNYMSETPANKSQGGSNQKGGNIILPLALIDKCIGNRIYVVMKGDKEFSGVLRGFDEYVNMVLDDVQEYGFKADEEDISGGNKKLKRVMVNRLETILLSGNNVAMLVPGGDPDSFNFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXY1</accession>
    <name>Q5CXY1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">T8M16_190 RRM protein of possible plant origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_4480</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90424.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628599.1">
        <property type="nucleotide sequence ID" value="XM_628597.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXY1"/>
    <dbReference type="FunCoup" id="Q5CXY1">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXY1"/>
    <dbReference type="GeneID" id="3372178"/>
    <dbReference type="KEGG" id="cpv:cgd7_4480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4480"/>
    <dbReference type="InParanoid" id="Q5CXY1"/>
    <dbReference type="OMA" id="SIMINIG"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050502">
        <property type="entry name" value="Euk_RNA-bind_prot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025">
        <property type="entry name" value="OS02G0815200 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48025:SF1">
        <property type="entry name" value="RRM DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="88"/>
            <end position="163"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="3">
        <location>
            <begin position="193"/>
            <end position="270"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90424.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="383" mass="44256" checksum="D46E2648F50288DF" modified="2005-04-12" version="1">MTNKIGAKKERDMESKEMLSNCQQLPCSALEFLTGEYELEEEGIVEFRNVVSLLSKEQLVDILSKSAYLYNIIGNACKLIVERSPVSRRVMVRNISFQTSDKVFLNLFEKFGEIEDSTIIREKNGRSRGYGFVTYKSSESIKKLFNENLILNGRQLLVKLAADPFSEFTCGPIDCNKQVMESNQRLTSTIFKKKLFIRNLSESTTNESLRQAFSEFEDIEECFVMRDHNTGKSRKYGFITFNNLGDMMKVLQHPERIVDGKVTFVSLAFKQKDTSNANKKSDTPATELQGSYPLSFPVQSGYFYDYYNALPQMQLDLQNTNLTSENVRNQHQMEVYPYVNQCYYSSNPCFTPYFIPYTPYGVYSNLYALQNNQEHNSKEEKEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXY7</accession>
    <name>Q5CXY7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">acid phosphatase</fullName>
            <ecNumber evidence="2">3.1.3.2</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_4420</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>a phosphate monoester + H2O = an alcohol + phosphate</text>
            <dbReference type="Rhea" id="RHEA:15017"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30879"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:67140"/>
            <dbReference type="EC" id="3.1.3.2"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.2" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90418.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628593.1">
        <property type="nucleotide sequence ID" value="XM_628591.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXY7"/>
    <dbReference type="STRING" id="353152.Q5CXY7"/>
    <dbReference type="GeneID" id="3372172"/>
    <dbReference type="KEGG" id="cpv:cgd7_4420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4420"/>
    <dbReference type="InParanoid" id="Q5CXY7"/>
    <dbReference type="OMA" id="NIAWREV"/>
    <dbReference type="OrthoDB" id="411211at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003993">
        <property type="term" value="F:acid phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07378">
        <property type="entry name" value="MPP_ACP5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024927">
        <property type="entry name" value="Acid_PPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051558">
        <property type="entry name" value="Metallophosphoesterase_PAP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10161:SF14">
        <property type="entry name" value="TARTRATE-RESISTANT ACID PHOSPHATASE TYPE 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253960" description="acid phosphatase" evidence="5">
        <location>
            <begin position="25"/>
            <end position="826"/>
        </location>
    </feature>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="6">
        <location>
            <begin position="46"/>
            <end position="257"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012646"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90418.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="826" mass="93750" checksum="2A2AEAE0ED18D5F8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXZ3</accession>
    <name>Q5CXZ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Glycoprotein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90413.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628587.1">
        <property type="nucleotide sequence ID" value="XM_628585.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXZ3"/>
    <dbReference type="GeneID" id="3372167"/>
    <dbReference type="KEGG" id="cpv:cgd7_4330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4330"/>
    <dbReference type="InParanoid" id="Q5CXZ3"/>
    <dbReference type="OMA" id="TNETNTH"/>
    <dbReference type="OrthoDB" id="342798at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="176"/>
            <end position="190"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90413.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="594" mass="63914" checksum="320E8CBF154BD8A3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="113" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY45</accession>
    <name>Q5CY45_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6 21">DNA-directed RNA polymerase subunit beta</fullName>
            <ecNumber evidence="5 21">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="29" type="ORF">cgd7_3720</name>
    </gene>
    <organism evidence="29 30">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="29 30" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="30">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1 21">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="19 21">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="18">In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="3">Plastid</location>
            <location evidence="3">Apicoplast</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4 20">Belongs to the RNA polymerase beta chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="29">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="5 21"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90367.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628535.1">
        <property type="nucleotide sequence ID" value="XM_628533.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY45"/>
    <dbReference type="FunCoup" id="Q5CY45">
        <property type="interactions" value="454"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY45"/>
    <dbReference type="GeneID" id="3372122"/>
    <dbReference type="KEGG" id="cpv:cgd7_3720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3720"/>
    <dbReference type="InParanoid" id="Q5CY45"/>
    <dbReference type="OMA" id="CYDRNDS"/>
    <dbReference type="OrthoDB" id="10248617at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020011">
        <property type="term" value="C:apicoplast"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000428">
        <property type="term" value="C:DNA-directed RNA polymerase complex"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="term" value="F:DNA binding"/>
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        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032549">
        <property type="term" value="F:ribonucleoside binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00653">
        <property type="entry name" value="RNA_pol_B_RPB2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.270.10:FF:000011">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.150:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1800.10:FF:000002">
        <property type="entry name" value="DNA-directed RNA polymerase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1070.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1100.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.270.10">
        <property type="entry name" value="DNA-directed RNA polymerase, subunit 2, domain 6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1800.10">
        <property type="entry name" value="RNA polymerase alpha subunit dimerisation domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1110.10">
        <property type="entry name" value="RNA polymerase Rpb2, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015712">
        <property type="entry name" value="DNA-dir_RNA_pol_su2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007120">
        <property type="entry name" value="DNA-dir_RNAP_su2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037033">
        <property type="entry name" value="DNA-dir_RNAP_su2_hyb_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007121">
        <property type="entry name" value="RNA_pol_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007644">
        <property type="entry name" value="RNA_pol_bsu_protrusion"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007642">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037034">
        <property type="entry name" value="RNA_pol_Rpb2_2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007645">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007646">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007647">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007641">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014724">
        <property type="entry name" value="RNA_pol_RPB2_OB-fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF007175">
        <property type="entry name" value="PRK09606.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20856">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04563">
        <property type="entry name" value="RNA_pol_Rpb2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04561">
        <property type="entry name" value="RNA_pol_Rpb2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04565">
        <property type="entry name" value="RNA_pol_Rpb2_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04566">
        <property type="entry name" value="RNA_pol_Rpb2_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04567">
        <property type="entry name" value="RNA_pol_Rpb2_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00562">
        <property type="entry name" value="RNA_pol_Rpb2_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04560">
        <property type="entry name" value="RNA_pol_Rpb2_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01166">
        <property type="entry name" value="RNA_POL_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="15" id="KW-0933">Apicoplast</keyword>
    <keyword evidence="7 21" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="14" id="KW-0460">Magnesium</keyword>
    <keyword evidence="11" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10 21" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="17" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-0934">Plastid</keyword>
    <keyword evidence="30" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="16 21" id="KW-0804">Transcription</keyword>
    <keyword evidence="9 21" id="KW-0808">Transferase</keyword>
    <keyword evidence="13" id="KW-0862">Zinc</keyword>
    <keyword evidence="12" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RNA polymerase beta subunit protrusion" evidence="25">
        <location>
            <begin position="33"/>
            <end position="436"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="24">
        <location>
            <begin position="203"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="26">
        <location>
            <begin position="463"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="27">
        <location>
            <begin position="562"/>
            <end position="622"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="28">
        <location>
            <begin position="658"/>
            <end position="704"/>
        </location>
    </feature>
    <feature type="domain" description="DNA-directed RNA polymerase subunit 2 hybrid-binding" evidence="22">
        <location>
            <begin position="711"/>
            <end position="1081"/>
        </location>
    </feature>
    <feature type="domain" description="RNA polymerase Rpb2" evidence="23">
        <location>
            <begin position="1083"/>
            <end position="1174"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004026"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006835"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00012418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00021955"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022640"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022887"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00026088"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00048552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="RuleBase" id="RU000434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="RuleBase" id="RU363031"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="22">
        <source>
            <dbReference type="Pfam" id="PF00562"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="23">
        <source>
            <dbReference type="Pfam" id="PF04560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="24">
        <source>
            <dbReference type="Pfam" id="PF04561"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="25">
        <source>
            <dbReference type="Pfam" id="PF04563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="26">
        <source>
            <dbReference type="Pfam" id="PF04565"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="27">
        <source>
            <dbReference type="Pfam" id="PF04566"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="28">
        <source>
            <dbReference type="Pfam" id="PF04567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="29">
        <source>
            <dbReference type="EMBL" id="EAK90367.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="30">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1177" mass="133726" checksum="2E7363EDAFF18C76" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYL8</accession>
    <name>Q5CYL8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Structural maintenance of chromosomes protein 4</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd7_1850</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SMC family. SMC4 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90607.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
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    <dbReference type="RefSeq" id="XP_628362.1">
        <property type="nucleotide sequence ID" value="XM_628360.1"/>
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    <dbReference type="KEGG" id="cpv:cgd7_1850"/>
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    <dbReference type="OMA" id="CPALDNM"/>
    <dbReference type="OrthoDB" id="5575062at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000796">
        <property type="term" value="C:condensin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007076">
        <property type="term" value="P:mitotic chromosome condensation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000481">
        <property type="entry name" value="Structural maintenance of chromosomes 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.1490">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1060.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1620">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003395">
        <property type="entry name" value="RecF/RecN/SMC_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024704">
        <property type="entry name" value="SMC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010935">
        <property type="entry name" value="SMC_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036277">
        <property type="entry name" value="SMC_hinge_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937:SF172">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18937">
        <property type="entry name" value="STRUCTURAL MAINTENANCE OF CHROMOSOMES SMC FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06470">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02463">
        <property type="entry name" value="SMC_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005719">
        <property type="entry name" value="SMC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00968">
        <property type="entry name" value="SMC_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75553">
        <property type="entry name" value="Smc hinge domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="11" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 12" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0226">DNA condensation</keyword>
    <keyword evidence="6" id="KW-0498">Mitosis</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SMC hinge" evidence="14">
        <location>
            <begin position="618"/>
            <end position="735"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="843"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1063"/>
            <end position="1084"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1340"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="258"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="315"/>
            <end position="566"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="12">
        <location>
            <begin position="787"/>
            <end position="835"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="850"/>
            <end position="862"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="1340"/>
            <end position="1355"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1356"/>
            <end position="1366"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006005"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00018693"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK90607.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1366" mass="156083" checksum="87CE690AF898ECB3" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYP7</accession>
    <name>Q5CYP7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="14 15">Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase</fullName>
            <ecNumber evidence="4 15">2.7.4.24</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">cgd7_1500</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="15">Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="13">
            <text>1D-myo-inositol hexakisphosphate + ATP = 1-diphospho-1D-myo-inositol 2,3,4,5,6-pentakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:37459"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58130"/>
            <dbReference type="ChEBI" id="CHEBI:74946"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="13">
            <dbReference type="Rhea" id="RHEA:37460"/>
        </physiologicalReaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>5-diphospho-1D-myo-inositol 1,2,3,4,6-pentakisphosphate + ATP + H(+) = 1,5-bis(diphospho)-1D-myo-inositol 2,3,4,6-tetrakisphosphate + ADP</text>
            <dbReference type="Rhea" id="RHEA:10276"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:58628"/>
            <dbReference type="ChEBI" id="CHEBI:77983"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.4.24"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="12">
            <dbReference type="Rhea" id="RHEA:10277"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
            <location evidence="1">Cytoskeleton</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2 15">Cytoplasm</location>
            <location evidence="2 15">Cytosol</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 15">Belongs to the histidine acid phosphatase family. VIP1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.24" evidence="4 15"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90204.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628333.1">
        <property type="nucleotide sequence ID" value="XM_628331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYP7"/>
    <dbReference type="FunCoup" id="Q5CYP7">
        <property type="interactions" value="10"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYP7"/>
    <dbReference type="GeneID" id="3372250"/>
    <dbReference type="KEGG" id="cpv:cgd7_1500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1500"/>
    <dbReference type="InParanoid" id="Q5CYP7"/>
    <dbReference type="OMA" id="IQERWCC"/>
    <dbReference type="OrthoDB" id="18042at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005856">
        <property type="term" value="C:cytoskeleton"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033857">
        <property type="term" value="F:5-diphosphoinositol pentakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052723">
        <property type="term" value="F:inositol hexakisphosphate 1-kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052843">
        <property type="term" value="F:inositol-1-diphosphate-2,3,4,5,6-pentakisphosphate diphosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006020">
        <property type="term" value="P:inositol metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032958">
        <property type="term" value="P:inositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07061">
        <property type="entry name" value="HP_HAP_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.470.20:FF:000036">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.11950:FF:000002">
        <property type="entry name" value="Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.11950">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.20">
        <property type="entry name" value="ATP-grasp fold, B domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1240">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033379">
        <property type="entry name" value="Acid_Pase_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000560">
        <property type="entry name" value="His_Pase_clade-2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037446">
        <property type="entry name" value="His_Pase_VIP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029033">
        <property type="entry name" value="His_PPase_superfam"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040557">
        <property type="entry name" value="VIP1_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750">
        <property type="entry name" value="DIPHOSPHOINOSITOL PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12750:SF9">
        <property type="entry name" value="INOSITOL HEXAKISPHOSPHATE AND DIPHOSPHOINOSITOL-PENTAKISPHOSPHATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00328">
        <property type="entry name" value="His_Phos_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18086">
        <property type="entry name" value="PPIP5K2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56059">
        <property type="entry name" value="Glutathione synthetase ATP-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53254">
        <property type="entry name" value="Phosphoglycerate mutase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00616">
        <property type="entry name" value="HIS_ACID_PHOSPHAT_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="10 15" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 15" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="11" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9 15" id="KW-0418">Kinase</keyword>
    <keyword evidence="8 15" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 15" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="VIP1 N-terminal" evidence="16">
        <location>
            <begin position="13"/>
            <end position="99"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00033696"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00034629"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00071668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="RuleBase" id="RU365032"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="Pfam" id="PF18086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAK90204.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1014" mass="117539" checksum="DD4BE2F629F7D9DF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYV5</accession>
    <name>Q5CYV5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_870</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90564.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628275.1">
        <property type="nucleotide sequence ID" value="XM_628273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYV5"/>
    <dbReference type="GeneID" id="3371986"/>
    <dbReference type="KEGG" id="cpv:cgd7_870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_870"/>
    <dbReference type="InParanoid" id="Q5CYV5"/>
    <dbReference type="OMA" id="VYLNIME"/>
    <dbReference type="OrthoDB" id="337603at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="188"/>
            <end position="229"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90564.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="259" mass="30055" checksum="A833FCA80D7A07AB" modified="2005-04-12" version="1">MKASRYHQILNQWIGKTKGFIIDENKDANTIQVTGESKLNRNKDSDTEWGSKWRFGENENDSKKGEKELVGVVSSIPSLTDIIRPFGDLPNDVYMDIMSKYKCFLHELKLKLIEIFRINSEKFKIQYKLDIVDERLALVEELGQEVYKLSAADLARIHTQKDKEECLMVDRLVPVVEKAKSLIIVEEEKFLLELNSKLRTNLDQLTKEFHELQTQISQVDKQLKDADETSNSFITDAIETFRKWSENAKEVIKAVERAN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPT1</accession>
    <name>A3FPT1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Ribosomal protein S23</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_1390</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS12 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51504.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388310.1">
        <property type="nucleotide sequence ID" value="XM_001388273.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPT1"/>
    <dbReference type="FunCoup" id="A3FPT1">
        <property type="interactions" value="367"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPT1"/>
    <dbReference type="GeneID" id="3375935"/>
    <dbReference type="KEGG" id="cpv:cgd6_1390"/>
    <dbReference type="InParanoid" id="A3FPT1"/>
    <dbReference type="OMA" id="KFRWSQR"/>
    <dbReference type="OrthoDB" id="1713912at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03367">
        <property type="entry name" value="Ribosomal_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000007">
        <property type="entry name" value="40S ribosomal protein S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006032">
        <property type="entry name" value="Ribosomal_uS12"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005680">
        <property type="entry name" value="Ribosomal_uS12_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00982">
        <property type="entry name" value="uS12_E_A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11652">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00164">
        <property type="entry name" value="Ribosom_S12_S23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00055">
        <property type="entry name" value="RIBOSOMAL_S12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005657"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51504.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="161" mass="18104" checksum="970A720A27B1C774" modified="2007-04-03" version="1" fragment="single">VNIETTIDLYLKYFNFHSIGKPKGINTARELRTRRRTQKWADKQYKRANLGTRYKSNPFGGASHAKGIVVERFGIEAKQPNSAVRKCVRVQLIKNGKKITAFVPRDGCLNYIDENDEVLVAGFGRKGHSVGDIPGVRFKAVKVSGVSLLALFKEKKEKPRS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQA2</accession>
    <name>A3FQA2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Eukaryotic ribosome biogenesis Erb1p, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_3680</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51411.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388238.1">
        <property type="nucleotide sequence ID" value="XM_001388201.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQA2"/>
    <dbReference type="FunCoup" id="A3FQA2">
        <property type="interactions" value="344"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQA2"/>
    <dbReference type="GeneID" id="3373535"/>
    <dbReference type="KEGG" id="cpv:cgd2_3680"/>
    <dbReference type="InParanoid" id="A3FQA2"/>
    <dbReference type="OMA" id="MRPAKGE"/>
    <dbReference type="OrthoDB" id="5571054at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070545">
        <property type="term" value="C:PeBoW complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030687">
        <property type="term" value="C:preribosome, large subunit precursor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043021">
        <property type="term" value="F:ribonucleoprotein complex binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR028598">
        <property type="entry name" value="BOP1/Erb1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012953">
        <property type="entry name" value="BOP1_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR17605">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BOP1 BLOCK OF PROLIFERATION 1 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08145">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01035">
        <property type="entry name" value="BOP1NT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="4" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="BOP1 N-terminal" evidence="8">
        <location>
            <begin position="10"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="363"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="7">
        <location>
            <begin position="363"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="7">
        <location>
            <begin position="377"/>
            <end position="386"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="SMART" id="SM01035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51411.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="669" mass="75894" checksum="E87987BF9A842613" modified="2007-04-03" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQA3</accession>
    <name>A3FQA3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">FCP1 homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_3810</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51412.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388239.1">
        <property type="nucleotide sequence ID" value="XM_001388202.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQA3"/>
    <dbReference type="STRING" id="353152.A3FQA3"/>
    <dbReference type="GeneID" id="3373534"/>
    <dbReference type="KEGG" id="cpv:cgd2_3810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3810"/>
    <dbReference type="InParanoid" id="A3FQA3"/>
    <dbReference type="OMA" id="FGMHLEN"/>
    <dbReference type="OrthoDB" id="277011at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd07521">
        <property type="entry name" value="HAD_FCP1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.1000:FF:000093">
        <property type="entry name" value="NLI interacting factor-like phosphatase family protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011948">
        <property type="entry name" value="Dullard_phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004274">
        <property type="entry name" value="FCP1_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050365">
        <property type="entry name" value="TIM50"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02251">
        <property type="entry name" value="HIF-SF_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12210">
        <property type="entry name" value="DULLARD PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03031">
        <property type="entry name" value="NIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00577">
        <property type="entry name" value="CPDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50969">
        <property type="entry name" value="FCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="FCP1 homology" evidence="2">
        <location>
            <begin position="336"/>
            <end position="475"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="225"/>
            <end position="253"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50969"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51412.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="475" mass="53917" checksum="E8F323314788B779" modified="2007-04-03" version="1">MSKSSSKELKVVHSKEKLNNKLFHEFNSHTISTNDSRDNEDSLLAISSINAIPTSLKISKKHTTSKINNQIVNNSYNSVIGEENEEKEYSYNKFKSQELDHQEIKKSNTGQKKKKWHQKFKLSFLLFSYNKNIEKNKVKSIKDNSNINKMEQNKENMNSYNHKHSWTLPLKDFTSSTKKENFESNNSNLSIGNNHIAFSTQTCSSSLPKSLNSHISYIPTTKSPTSFTNTSYISSSPSSSSSSSSSSSSSSSSASFLTPSSSTQLFSPKMSLISSYITQEEEVLEAGIYDKDNLGRNGFSLRSITGDRESIIYDEDYESYLESTIKEPFLEPQRREYIGRKTLVLDLDETLIHSSFQPIRNASFTINIEIDGDYYDVYVLKRPGVDKFLNIVSAIFEVVIFTASLSKYANPLLDRLDPMNKCPYRLFRENCTVEGNSYIKDLSKLGRPLKDIIIIDNSPISYILQPENAIPISSW</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="86" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQB9</accession>
    <name>A3FQB9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Dynamin-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_580</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51318.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388141.1">
        <property type="nucleotide sequence ID" value="XM_001388104.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQB9"/>
    <dbReference type="STRING" id="353152.A3FQB9"/>
    <dbReference type="GeneID" id="3371500"/>
    <dbReference type="KEGG" id="cpv:cgd1_580"/>
    <dbReference type="InParanoid" id="A3FQB9"/>
    <dbReference type="OMA" id="MAFRYVK"/>
    <dbReference type="OrthoDB" id="5061070at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005874">
        <property type="term" value="C:microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08771">
        <property type="entry name" value="DLP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.120.1240">
        <property type="entry name" value="Dynamin, middle domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022812">
        <property type="entry name" value="Dynamin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001401">
        <property type="entry name" value="Dynamin_GTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045063">
        <property type="entry name" value="Dynamin_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000375">
        <property type="entry name" value="Dynamin_stalk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030381">
        <property type="entry name" value="G_DYNAMIN_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003130">
        <property type="entry name" value="GED"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020850">
        <property type="entry name" value="GED_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566:SF233">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_59, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11566">
        <property type="entry name" value="DYNAMIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01031">
        <property type="entry name" value="Dynamin_M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00350">
        <property type="entry name" value="Dynamin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02212">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00195">
        <property type="entry name" value="DYNAMIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00053">
        <property type="entry name" value="DYNc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00302">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51718">
        <property type="entry name" value="G_DYNAMIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51388">
        <property type="entry name" value="GED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Dynamin-type G" evidence="5">
        <location>
            <begin position="1"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="domain" description="GED" evidence="4">
        <location>
            <begin position="542"/>
            <end position="633"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="657"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="673"/>
            <end position="691"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="3">
        <location>
            <begin position="702"/>
            <end position="715"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="717"/>
            <end position="728"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51718"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51318.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="752" mass="84491" checksum="B83A0C7D62FB226F" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQE6</accession>
    <name>A3FQE6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Actin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_2480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the actin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51345.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388168.1">
        <property type="nucleotide sequence ID" value="XM_001388131.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQE6"/>
    <dbReference type="STRING" id="353152.A3FQE6"/>
    <dbReference type="GeneID" id="3371401"/>
    <dbReference type="KEGG" id="cpv:cgd1_2480"/>
    <dbReference type="InParanoid" id="A3FQE6"/>
    <dbReference type="OMA" id="MFHNFVG"/>
    <dbReference type="OrthoDB" id="5132116at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004000">
        <property type="entry name" value="Actin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11937">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00022">
        <property type="entry name" value="Actin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00268">
        <property type="entry name" value="ACTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00049360"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU000487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51345.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="396" mass="43963" checksum="7569DE58F921EA6D" modified="2007-04-03" version="1">MSDMILSSGIGSQSSSIILDIGTQSIRAGYGGDDLPRSVVPTCIGIPNKEVDLIDSNRLCNTIFPLKPWEKRDYIEVLHPLQYNIQEKAIEFNEEYLTKIIQELSLSQKFTNSTSSFLTKHNYIFEPLDDRMNGQTLLIPIHSTSNPNNSIKLAEIAFEKLEVASLFTSRRPVLSCFACGRTSGIVVDIGASVSNVSCVQDGHCIQGSIQEYPVAGDFLDNEIYKKIHKVNIIPEFGIFKNEDKNGASEYHVPLTNVDESYLTWGIMHVIREIKHSSLFFPNPNSNNENEFHLPDGNVIDTTSIRNSIPNLLFKSGNSNQGYPGIVQMVINSITETSNINKEISSITSSIILAGGTTLINGFDAKLHQGIIDQRPSVIFNNSVSFLKSNYKIYSAF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQJ3</accession>
    <name>A3FQJ3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Helicase ATP-binding domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_2970</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388277.1">
        <property type="nucleotide sequence ID" value="XM_001388240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQJ3"/>
    <dbReference type="STRING" id="353152.A3FQJ3"/>
    <dbReference type="GeneID" id="3373323"/>
    <dbReference type="KEGG" id="cpv:cgd5_2970"/>
    <dbReference type="InParanoid" id="A3FQJ3"/>
    <dbReference type="OMA" id="AELAICK"/>
    <dbReference type="OrthoDB" id="344095at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="5">
        <location>
            <begin position="174"/>
            <end position="357"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="622" mass="72591" checksum="C4B57087CD605923" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPJ3</accession>
    <name>Q5CPJ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical, possible apicomplexan-specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_160</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87342.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625356.1">
        <property type="nucleotide sequence ID" value="XM_625356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPJ3"/>
    <dbReference type="GeneID" id="3375637"/>
    <dbReference type="KEGG" id="cpv:cgd6_160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_160"/>
    <dbReference type="InParanoid" id="Q5CPJ3"/>
    <dbReference type="OMA" id="FTHLEAY"/>
    <dbReference type="OrthoDB" id="339218at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87342.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="690" mass="80941" checksum="605ABEE8F6FB3C4E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPL2</accession>
    <name>Q5CPL2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide, serine proline rich, possible low mw mucin glycoprotein locus of 6 genes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87365.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625409.1">
        <property type="nucleotide sequence ID" value="XM_625409.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPL2"/>
    <dbReference type="STRING" id="353152.Q5CPL2"/>
    <dbReference type="GeneID" id="3372379"/>
    <dbReference type="KEGG" id="cpv:cgd2_420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_420"/>
    <dbReference type="InParanoid" id="Q5CPL2"/>
    <dbReference type="OrthoDB" id="10568768at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254084" evidence="2">
        <location>
            <begin position="20"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="39"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="51"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="68"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="166"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87365.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="205" mass="22010" checksum="24EBA8E472949C59" modified="2005-04-12" version="1">MKFLYVFLCLICLLNYTTFNQLGRVDEHSKMSLIKLKSLNLGSSGPSNDEESLKGTGDRPDGTGCNDSSSSSSSLNNPEGDEENDPEGDEGNDPEGDEGNDPNPFAGVSLSSPRPRRRNPWRYGNKGKPTHSNSESDGKLGPFDGANLKSPRLGRRRPRGRGNQGGSSNSGSDSGGDTSQFGDPSPRPPSPYKTTPRCSKLKGRF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPT6</accession>
    <name>Q5CPT6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Putative Sec14d</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_4090</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87433.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625428.1">
        <property type="nucleotide sequence ID" value="XM_625428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPT6"/>
    <dbReference type="STRING" id="353152.Q5CPT6"/>
    <dbReference type="GeneID" id="3372418"/>
    <dbReference type="KEGG" id="cpv:cgd4_4090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4090"/>
    <dbReference type="InParanoid" id="Q5CPT6"/>
    <dbReference type="OrthoDB" id="1434354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.680">
        <property type="entry name" value="GOLD domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036273">
        <property type="entry name" value="CRAL/TRIO_N_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036598">
        <property type="entry name" value="GOLD_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051064">
        <property type="entry name" value="SEC14/CRAL-TRIO_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324">
        <property type="entry name" value="SEC14 RELATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23324:SF83">
        <property type="entry name" value="SEC14-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00516">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46938">
        <property type="entry name" value="CRAL/TRIO N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101576">
        <property type="entry name" value="Supernatant protein factor (SPF), C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CRAL-TRIO" evidence="2">
        <location>
            <begin position="167"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="561"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="617"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="817"/>
            <end position="866"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="568"/>
            <end position="596"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="817"/>
            <end position="830"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="831"/>
            <end position="866"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87433.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1063" mass="123193" checksum="00EB1D0C39DA2272" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ00</accession>
    <name>Q5CQ00_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">CpTSP4 extracellular protein with signal peptide and 2 repeats of an apple domain followed by a TSP1 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_150</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625479.1">
        <property type="nucleotide sequence ID" value="XM_625479.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ00"/>
    <dbReference type="STRING" id="353152.Q5CQ00"/>
    <dbReference type="GeneID" id="3372500"/>
    <dbReference type="KEGG" id="cpv:cgd8_150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_150"/>
    <dbReference type="InParanoid" id="Q5CQ00"/>
    <dbReference type="OMA" id="CAGITHR"/>
    <dbReference type="OrthoDB" id="98591at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000177">
        <property type="entry name" value="Apple"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039942">
        <property type="entry name" value="SBSPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920">
        <property type="entry name" value="RPE-SPONDIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20920:SF5">
        <property type="entry name" value="SMB DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00223">
        <property type="entry name" value="APPLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="Apple" evidence="3">
        <location>
            <begin position="76"/>
            <end position="149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="488" mass="55355" checksum="2699ABB309BB2141" modified="2007-04-03" version="1">MFQKILTFTTLLISLLIIYINVSWSNKYITPEKFSETHPDSAMMKLVSPENSVPIDIPDLPASNITKKYCPIYGLNMKGLFCLGWNSIKIKKADSWQECASLCMDYVAFFFIKCKKWSYDVEKKKCLIKSGDRLCKYPDENYISGLKNASEVGPCSTTCKVGDWSAWTPCSSYCAGITQRVRHVIRSPVYKSEICPRLIETAMCKGSPDCPSNCPNYHVVGLGWGCKVEMNRGGGTMRKYVNTWHECLGLCKITENCTYWSFQGISGVETCLLVIGEVGCTYHALGWISGDVNVVAIDCPVKCFVGEWSNWSKCPNDDVCTQNSMSKRSRPLISTPPDMNQKMCPHLTESIMCECATKITRNTAFDDYNRNLISYNNSTTQDSLQNDPEIRAMSASANRMSRSKMGAYSTENLLKNLYFDFRENYQILNDQNHSYPRTQVDEESQNEDFTLRKGIDNSYDIHFALSSYLLGVNYTNFRNSTLDPNLFN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ07</accession>
    <name>Q5CQ07_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">10 transmembrane domain, possible aa transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_80</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625472.1">
        <property type="nucleotide sequence ID" value="XM_625472.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ07"/>
    <dbReference type="STRING" id="353152.Q5CQ07"/>
    <dbReference type="GeneID" id="3372491"/>
    <dbReference type="KEGG" id="cpv:cgd8_80"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_80"/>
    <dbReference type="InParanoid" id="Q5CQ07"/>
    <dbReference type="OMA" id="FTCHENM"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="68"/>
            <end position="87"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="94"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="143"/>
            <end position="166"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="178"/>
            <end position="197"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="209"/>
            <end position="228"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="295"/>
            <end position="318"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="338"/>
            <end position="355"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="383"/>
            <end position="402"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="408"/>
            <end position="431"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="443"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="59"/>
            <end position="462"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="470" mass="51918" checksum="0ED202BF893039CF" modified="2005-04-12" version="1">MNSNMSKPLLEIRGNGCRNLSRSSISSYKTMNRTQSLAIYGLFEDEPETLPGLGGAIQGSSLSEAVSAMVNTMLGIGTLAIPLAYAANGLLQGILLTIFCAFLSSLSLYLLSSIAMEYGDDVSFYSVTANHMPGLKLIVDSAIVIKSLGVSTSYLMVVGDLVYSLFFYNNSFGIDPKVLRAIVLLTSVVFFIAPASFPHKLKSMKYTNWLSVICILYVVAVVFFRLMYSVRTTYLPGLEEQPAFLTGNLDYFSTLSLRRTLETFPILIFAFTCQQNIFTVSNELHNRTLNRLSKIIIISIGTGVVVYSIIGISGYLLFGRLINKANVLELFKTNTLDIFIAKFFIAVSMVFSFPIQCHPCRRSLSILLYSGVTEMEPKAEKRALNLITVFILVLTTSCAIYFTNLGLAYELVGTICSNTTAFIIPSLLYIKVFDHKGLTIEKLLAFFLLIMAVLILILCLSAIFIGLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ25</accession>
    <name>Q5CQ25_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="1">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd5_4390</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87586.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625601.1">
        <property type="nucleotide sequence ID" value="XM_625601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ25"/>
    <dbReference type="STRING" id="353152.Q5CQ25"/>
    <dbReference type="GeneID" id="3372546"/>
    <dbReference type="KEGG" id="cpv:cgd5_4390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4390"/>
    <dbReference type="InParanoid" id="Q5CQ25"/>
    <dbReference type="OrthoDB" id="4062651at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008266">
        <property type="entry name" value="Tyr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343:SF466">
        <property type="entry name" value="AMP-ACTIVATED PROTEIN KINASE ALPHA SUBUNIT, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24343">
        <property type="entry name" value="SERINE/THREONINE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00109">
        <property type="entry name" value="PROTEIN_KINASE_TYR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 11" id="KW-0418">Kinase</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="381"/>
            <end position="790"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="113"/>
            <end position="132"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="191"/>
            <end position="235"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="9">
        <location>
            <begin position="192"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="9">
        <location>
            <begin position="207"/>
            <end position="228"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87586.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="796" mass="91174" checksum="1736BCC5AADA33B5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="69" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ73</accession>
    <name>Q5CQ73_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Possible apicomplexan specific, low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_3890</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DCP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87538.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625553.1">
        <property type="nucleotide sequence ID" value="XM_625553.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ73"/>
    <dbReference type="STRING" id="353152.Q5CQ73"/>
    <dbReference type="GeneID" id="3372596"/>
    <dbReference type="KEGG" id="cpv:cgd5_3890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3890"/>
    <dbReference type="InParanoid" id="Q5CQ73"/>
    <dbReference type="OMA" id="NITREWE"/>
    <dbReference type="OrthoDB" id="440673at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008047">
        <property type="term" value="F:enzyme activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000290">
        <property type="term" value="P:deadenylation-dependent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031087">
        <property type="term" value="P:deadenylation-independent decapping of nuclear-transcribed mRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006397">
        <property type="term" value="P:mRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd09804">
        <property type="entry name" value="Dcp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010334">
        <property type="entry name" value="Dcp1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290:SF0">
        <property type="entry name" value="DECAPPING PROTEIN 1, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16290">
        <property type="entry name" value="TRANSCRIPTION FACTOR SMIF DECAPPING ENZYME DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06058">
        <property type="entry name" value="DCP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="223"/>
            <end position="242"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="5">
        <location>
            <begin position="2"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="6">
        <location>
            <begin position="223"/>
            <end position="239"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87538.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="324" mass="37409" checksum="498A68F8C8F37DFE" modified="2005-04-12" version="1">MNSLENQRKNNLEDERKKLNLQLLKRHDENINEIIAYSSFVSVYLMDGTTQKWVRGEVEGFLHIVKRDIEPIYQLIVLNQKNPENLILGITSEWELSGETNYLFYKFPNKNNNSLVSCLWFYEVEERKSIEASLKQIVSKLMVKKLNSDIDCNSSSSHGFQSDPTSIYNSNAGKTILEFLNKKSNQKNQEGEINIEQMIRNSVNNNKIIQASRIVTDDNIKNNVNNNNNNNNNNGNNTNIPDKHNIINNVESKSNSEKTVINDSLQKLLHFQDILGKGSKLESNYNRKNENITPEAITDIIMDVLSSRQVYNMINERIELLLRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQA0</accession>
    <name>Q5CQA0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Brx1p nucleolar protein required for biogenesis of the 60S ribosomal subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_1520</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the BRX1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87603.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625748.1">
        <property type="nucleotide sequence ID" value="XM_625748.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQA0"/>
    <dbReference type="FunCoup" id="Q5CQA0">
        <property type="interactions" value="406"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQA0"/>
    <dbReference type="GeneID" id="3372704"/>
    <dbReference type="KEGG" id="cpv:cgd4_1520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1520"/>
    <dbReference type="InParanoid" id="Q5CQA0"/>
    <dbReference type="OMA" id="YRHRHLM"/>
    <dbReference type="OrthoDB" id="1638493at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000027">
        <property type="term" value="P:ribosomal large subunit assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026532">
        <property type="entry name" value="BRX1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13634:SF0">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN BRX1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <feature type="domain" description="Brix" evidence="6">
        <location>
            <begin position="68"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87603.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="353" mass="41185" checksum="2A459B9190C42671" modified="2005-04-12" version="1">MPSKDNNTNMSSSSSSRIANASEDNEIKMDIEEGHITSNNNNNNINTDPYMMKGAEYLNKESRWKNKQRVLVLSTRGINFRHRHLMEDIKKLLPHHKSEVKWEKKQPFSEISEMSELRSCNNIILLEARRHEELYMWVAKCPNGPSIKFQILNIHTLGELRLAGNSLLGSRPLLSFDSAFESDNYVHNINFSQEQKHLKLPLKLIKDLFIQVFGTPRYHPKSKPFHDHVISFNFLDGKIWFRHYQIAPTTERDHNNVDKQVLIEIGPRFVLEPILILDGTFSGQVLYRNPDYKSPTLLRNIIKQGYSSSYLQRVQSKQKRSDYKDDLDSSLMNVPEKKMQILRSDNVDDFLLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQD6</accession>
    <name>Q5CQD6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative conserved protein with possible signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_1150</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87630.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625712.1">
        <property type="nucleotide sequence ID" value="XM_625712.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQD6"/>
    <dbReference type="GeneID" id="3372673"/>
    <dbReference type="KEGG" id="cpv:cgd4_1150"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1150"/>
    <dbReference type="InParanoid" id="Q5CQD6"/>
    <dbReference type="OrthoDB" id="77656at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007031">
        <property type="term" value="P:peroxisome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037485">
        <property type="entry name" value="PEX22"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34126">
        <property type="entry name" value="PEROXISOME BIOGENESIS PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR34126:SF1">
        <property type="entry name" value="PEROXISOME BIOGENESIS PROTEIN 22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22978">
        <property type="entry name" value="HAD_Pex22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="21"/>
            <end position="40"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87630.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="238" mass="27286" checksum="D2246CB4292AEB05" modified="2005-04-12" version="1">MSRKKEKLNAAKTNSSQNLQLLIVWTIFLGIIVLFFHLIYKYLIKNIFNYILNFISKKDSSFNENANNISTNNNNRDINTSSSAFDRGEIDANLQSGNFTSDNSIFRVSIGFCYSKEAENLKKLKVKESLIKLSGFTDLFLFIQVDTEQDELVILNYMQEFGIFEAGLKKHRLVFCEKPESIPNMARQLQANMHIDTNQDNAQKLLNKVPNISILTFDDDGDSLYELVETIENVVNSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQE5</accession>
    <name>Q5CQE5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">URB1 C-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_1020</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87637.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625703.1">
        <property type="nucleotide sequence ID" value="XM_625703.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQE5"/>
    <dbReference type="STRING" id="353152.Q5CQE5"/>
    <dbReference type="GeneID" id="3372680"/>
    <dbReference type="KEGG" id="cpv:cgd4_1020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1020"/>
    <dbReference type="InParanoid" id="Q5CQE5"/>
    <dbReference type="OMA" id="EFFLYGY"/>
    <dbReference type="OrthoDB" id="72892at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005730">
        <property type="term" value="C:nucleolus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000466">
        <property type="term" value="P:maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039844">
        <property type="entry name" value="URB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032436">
        <property type="entry name" value="URB1_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500:SF0">
        <property type="entry name" value="NUCLEOLAR PRE-RIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13500">
        <property type="entry name" value="NUCLEOLAR PRERIBOSOMAL-ASSOCIATED PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16201">
        <property type="entry name" value="NopRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="URB1 C-terminal" evidence="3">
        <location>
            <begin position="463"/>
            <end position="643"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="388"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="123"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="393"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="439"/>
            <end position="453"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF16201"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87637.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="911" mass="109948" checksum="63600D27AC6DF208" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQJ5</accession>
    <name>Q5CQJ5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Nucleoporin Nup54 alpha-helical domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625653.1">
        <property type="nucleotide sequence ID" value="XM_625653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQJ5"/>
    <dbReference type="STRING" id="353152.Q5CQJ5"/>
    <dbReference type="GeneID" id="3372702"/>
    <dbReference type="KEGG" id="cpv:cgd4_460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_460"/>
    <dbReference type="InParanoid" id="Q5CQJ5"/>
    <dbReference type="OMA" id="WQQRIDG"/>
    <dbReference type="OrthoDB" id="343430at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025712">
        <property type="entry name" value="Nup54_alpha-helical_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13874">
        <property type="entry name" value="Nup54"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nucleoporin Nup54 alpha-helical" evidence="3">
        <location>
            <begin position="179"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="331"/>
            <end position="365"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="197"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF13874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="435" mass="48820" checksum="D4D6123FE55854B8" modified="2005-04-12" version="1">MSFFNNLSTSGGQGLGFGGGTTSNFSFGNPSSTSTNLFDNKSSLFPTQSTLNSSNNALSTSFLNSNSTGTNLFGTSNSNQSQGTGLNLGTNSFSMNNTQFSSQTQSATLNMMNLPLQQRQELERIEKRKVSLQKGLSLQMNPTMTALTYQLDEKAPEKQQEVDNYIYYNLNDEGIIKNLNDAKKLNPNPSKCYTLPIKGFGELVQREQQQRKELENLLCEMKSVKDENVKILQTLNTSTIKRVEECKKRHQSIIHQLVHISCMIEEYGEKNHFAQVNYQLDNQLNQVLHQIQENHMKLGAWQSSINQIETNIKYIDEQLNDNDSKNCNDLKNLLESSPNKSGNNSFSDHLNSSDQKGSENNHSISDLNNRLQQNQQLSSTNGIYSDISKNSRETSTNSPSNVEAIFETLDSQQQLLESLSDTVRNDSLLIQQFIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQL5</accession>
    <name>Q5CQL5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Proteasome subunit alpha type</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_250</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="1">The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="6">The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="6">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5 6">Belongs to the peptidase T1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87732.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625633.1">
        <property type="nucleotide sequence ID" value="XM_625633.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQL5"/>
    <dbReference type="FunCoup" id="Q5CQL5">
        <property type="interactions" value="357"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQL5"/>
    <dbReference type="GeneID" id="3372663"/>
    <dbReference type="KEGG" id="cpv:cgd4_250"/>
    <dbReference type="InParanoid" id="Q5CQL5"/>
    <dbReference type="OMA" id="YVLNDNM"/>
    <dbReference type="OrthoDB" id="431557at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019773">
        <property type="term" value="C:proteasome core complex, alpha-subunit complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03752">
        <property type="entry name" value="proteasome_alpha_type_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.20.10:FF:000031">
        <property type="entry name" value="Proteasome subunit alpha type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.20.10">
        <property type="entry name" value="Glutamine Phosphoribosylpyrophosphate, subunit 1, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029055">
        <property type="entry name" value="Ntn_hydrolases_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050115">
        <property type="entry name" value="Proteasome_alpha"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023332">
        <property type="entry name" value="Proteasome_alpha-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000426">
        <property type="entry name" value="Proteasome_asu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016050">
        <property type="entry name" value="Proteasome_bsu_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001353">
        <property type="entry name" value="Proteasome_sua/b"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003075">
        <property type="entry name" value="PRK03996.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11599">
        <property type="entry name" value="PROTEASOME SUBUNIT ALPHA/BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00227">
        <property type="entry name" value="Proteasome"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10584">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00948">
        <property type="entry name" value="Proteasome_A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56235">
        <property type="entry name" value="N-terminal nucleophile aminohydrolases (Ntn hydrolases)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00388">
        <property type="entry name" value="PROTEASOME_ALPHA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51475">
        <property type="entry name" value="PROTEASOME_ALPHA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00854">
        <property type="entry name" value="PROTEASOME_BETA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="3 5 6" id="KW-0647">Proteasome</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Proteasome alpha-type subunits" evidence="7">
        <location>
            <begin position="15"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00002000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00808"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000551"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS00388"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87732.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="271" mass="30290" checksum="D753B342F3A96DB8" modified="2005-04-12" version="1" fragment="single">FNFGRDLLVEMSRRYDSRTTTFSPEGRLYQVEYALEAINNAAPTVGILCKEGVILGADKAIVSKLLDQGKSLEKIYTIDRHIIAAVAGLTADANILIAQARIDSQRYQYTYGEEQPVEQLVTQICDRKQSYTQFGGLRPFGVSFLFAGYDKNYGYQLYQSDPSGNFSGWKATAIGQNNQTATSLLKQEWNEDLTLEQGLHLVAKVLTKTMDTTSPTADKFEFSILTHNNESNKCSQKILSEKEIGELLEKVQKEIASENNAKNNSETNNQS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQN5</accession>
    <name>Q5CQN5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_20</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87708.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625613.1">
        <property type="nucleotide sequence ID" value="XM_625613.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQN5"/>
    <dbReference type="GeneID" id="3372608"/>
    <dbReference type="KEGG" id="cpv:cgd4_20"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_20"/>
    <dbReference type="InParanoid" id="Q5CQN5"/>
    <dbReference type="OrthoDB" id="340141at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254124" evidence="1">
        <location>
            <begin position="28"/>
            <end position="335"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87708.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="335" mass="39272" checksum="B03C43BFE029873D" modified="2005-04-12" version="1">MKRELLFSLKLLFYFTVTALIYNKANAETIINKVNNKNNNYKRPSYLIFGKNNILTPNYSKEVDCLGPPIYFFDVANRKIVSLKVTCKDTFLLINNNGELTVRLTDEVYYVNDRKAKKHFFFDYNFDPTTFIQKEYNDLTEVEHKTNYLLENNFNEIPIDYDTSNDGKYLDWIVKTEFLGVITISDTTVKLPNYNFGQPESEFEIKIPVETKLFLIFIIKTSLLGIQNTFFAAFPIFFLSKIIYDVRKPLLKFQFDQIGSNSSEIYDIKKGIHYYKGLKLKINKIHGEKILFSESLFELEKLIKDRFDKLKIELDSKHNLGIINFLNSVNNNEGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQS0</accession>
    <name>Q5CQS0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_3560</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87771.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625932.1">
        <property type="nucleotide sequence ID" value="XM_625932.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQS0"/>
    <dbReference type="GeneID" id="3372856"/>
    <dbReference type="KEGG" id="cpv:cgd4_3560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3560"/>
    <dbReference type="InParanoid" id="Q5CQS0"/>
    <dbReference type="OMA" id="CIRIKEK"/>
    <dbReference type="OrthoDB" id="341210at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87771.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="531" mass="60586" checksum="BEDE4F5FD33F2E30" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQU0</accession>
    <name>Q5CQU0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Pleckstrin homology (PH) domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3340</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87790.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625912.1">
        <property type="nucleotide sequence ID" value="XM_625912.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQU0"/>
    <dbReference type="GeneID" id="3372778"/>
    <dbReference type="KEGG" id="cpv:cgd4_3340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3340"/>
    <dbReference type="InParanoid" id="Q5CQU0"/>
    <dbReference type="OMA" id="MKAWEIS"/>
    <dbReference type="OrthoDB" id="2344588at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="CDD" id="cd00821">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.29.30">
        <property type="entry name" value="Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011993">
        <property type="entry name" value="PH-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001849">
        <property type="entry name" value="PH_domain"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00169">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00233">
        <property type="entry name" value="PH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50003">
        <property type="entry name" value="PH_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PH" evidence="1">
        <location>
            <begin position="28"/>
            <end position="125"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87790.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="742" mass="84337" checksum="DEBC2CBC491ED395" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQW0</accession>
    <name>Q5CQW0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein S27a, ubiquitin plus zincribbon, UB13p</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_3080</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1">In the N-terminal section; belongs to the ubiquitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87925.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625892.1">
        <property type="nucleotide sequence ID" value="XM_625892.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQW0"/>
    <dbReference type="FunCoup" id="Q5CQW0">
        <property type="interactions" value="202"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQW0"/>
    <dbReference type="GeneID" id="3372969"/>
    <dbReference type="KEGG" id="cpv:cgd4_3080"/>
    <dbReference type="InParanoid" id="Q5CQW0"/>
    <dbReference type="OMA" id="HANRHYC"/>
    <dbReference type="OrthoDB" id="1649877at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.150">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002906">
        <property type="entry name" value="Ribosomal_eS31"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038582">
        <property type="entry name" value="Ribosomal_eS31_euk-type_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000626">
        <property type="entry name" value="Ubiquitin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001669">
        <property type="entry name" value="PRK00432.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01599">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00240">
        <property type="entry name" value="ubiquitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01402">
        <property type="entry name" value="Ribosomal_S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50053">
        <property type="entry name" value="UBIQUITIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1017">Isopeptide bond</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5 8" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="4" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Ubiquitin-like" evidence="7">
        <location>
            <begin position="4"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008373"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022499"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50053"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87925.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="159" mass="17867" checksum="B279BB8DC471B754" modified="2005-04-12" version="1" fragment="single">LSKMQIFFRYGLGNTRSLEVDPTMSVKELRHIISEFSGISIDSQCISYGFGILDEFETLEQAGISDYSTLYVSEAMLGGAKKKKKNFTKPKKIKHKKKKVKLAVLKYYKVDGDKVVKLRRECPAETCGAGVFMAQHFNRTSCGRCGLTYFPSKGDEGKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQZ3</accession>
    <name>Q5CQZ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">IMP4 U3 small nucleolar ribonucleoprotein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2740</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87831.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625859.1">
        <property type="nucleotide sequence ID" value="XM_625859.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQZ3"/>
    <dbReference type="FunCoup" id="Q5CQZ3">
        <property type="interactions" value="404"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQZ3"/>
    <dbReference type="GeneID" id="3372838"/>
    <dbReference type="KEGG" id="cpv:cgd4_2740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2740"/>
    <dbReference type="InParanoid" id="Q5CQZ3"/>
    <dbReference type="OMA" id="IGTMSEQ"/>
    <dbReference type="OrthoDB" id="10253204at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034457">
        <property type="term" value="C:Mpp10 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042134">
        <property type="term" value="F:rRNA primary transcript binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030515">
        <property type="term" value="F:snoRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042274">
        <property type="term" value="P:ribosomal small subunit biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10480:FF:000001">
        <property type="entry name" value="IMP4, U3 small nucleolar ribonucleoprotein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10480">
        <property type="entry name" value="Probable brix-domain ribosomal biogenesis protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007109">
        <property type="entry name" value="Brix"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044281">
        <property type="entry name" value="IMP4/RPF1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22734:SF2">
        <property type="entry name" value="U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04427">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00879">
        <property type="entry name" value="Brix"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50833">
        <property type="entry name" value="BRIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Brix" evidence="1">
        <location>
            <begin position="82"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87831.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="288" mass="33332" checksum="A1134B74334C9CB7" modified="2005-04-12" version="1">MLRRNARQRKEYISRKGLERVEKNIFERSVRFKEALDEGRQIPTEYKNVSDKIVANIDLFDTSIDPKSIVDDEYSLSGLYEPKILITTSRSPSSRLLQFVKELNLVIPNSFRINRGGYVLNDFGDLCRSNGATDLVVVHEHRGEPDGLIISHFPYGPTAYFAISDVVLRHDLPIKPSTMSQSIPHLIFQNFNSTLGLRVSNILKHLFPKLKNASQRVISFVNINDNIIFRHFSWDKDITDKSEEIQLNEIGPRFILKLYKIELGTLEMKNLSIEWVHRPFFNKKKTSL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR15</accession>
    <name>Q5CR15_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87850.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625837.1">
        <property type="nucleotide sequence ID" value="XM_625837.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR15"/>
    <dbReference type="GeneID" id="3372876"/>
    <dbReference type="KEGG" id="cpv:cgd4_2490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2490"/>
    <dbReference type="InParanoid" id="Q5CR15"/>
    <dbReference type="OMA" id="QWSSIAF"/>
    <dbReference type="OrthoDB" id="337276at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254280" evidence="2">
        <location>
            <begin position="19"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="178"/>
            <end position="202"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87850.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="237" mass="26915" checksum="31488ADA2E03DE01" modified="2005-04-12" version="1">MYFVWIRFSIYLFILSCADVIYSDLQDTDIFLVDIYRLNQNVIVSSIYNASNPNEYITNISDPQGIYPIITKTPIDEPKLIDSDTVQILGQEYKVKQYKPLGLQKCLTPSYNINSCQKICVSGYSGTVLSVFNSYALVYITQNNHFQLNITNASELEVDGKKVKYAITGCSVSTLNTVIWGFLTFTVIFSFLVFALFAFEIIEYLRFKADMKDPLIIGGEIRTISSRDFSLESFSTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR16</accession>
    <name>Q5CR16_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2480</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625836.1">
        <property type="nucleotide sequence ID" value="XM_625836.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR16"/>
    <dbReference type="GeneID" id="3372875"/>
    <dbReference type="KEGG" id="cpv:cgd4_2480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2480"/>
    <dbReference type="InParanoid" id="Q5CR16"/>
    <dbReference type="OrthoDB" id="341176at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254856" evidence="1">
        <location>
            <begin position="20"/>
            <end position="200"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="200" mass="21959" checksum="F21DA728F3794F0B" modified="2005-04-12" version="1">MIFSILFFSVFILASKIHCSSFRSFSENDQLSKYEDNNKTNSLITLSANHSDIIDSTLDSPVTRVMDDILIQERPVLLNTIPHTALSHNLFVNSSGLFTNITVILTSTVPIAIVSPENDSIHRILSGSETNKTLGSIKMDLEKISENISKSMDKLPKEIMNVVENTGEYFEKLSSLLAGVANLGDNSGSNSTVLEPAHNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="129" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR27</accession>
    <name>Q5CR27_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 12">Lysine--tRNA ligase</fullName>
            <ecNumber evidence="3 12">6.1.1.6</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10 12">Lysyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd4_2370</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="19" key="2">
        <citation type="submission" date="2017-11" db="PDB data bank">
            <title>Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-lysine and Adenosine.</title>
            <authorList>
                <person name="Dranow D.M."/>
                <person name="Lorimer D."/>
                <person name="Edwards T.E."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 46-559 IN COMPLEX WITH ADENOSINE</scope>
    </reference>
    <reference evidence="20" key="3">
        <citation type="submission" date="2018-01" db="PDB data bank">
            <title>Crystal Structure of Lysyl-tRNA Synthetase from Cryptosporidium parvum complexed with L-Lysylsulfamoyl Adenosine.</title>
            <authorList>
                <person name="Dranow D.M."/>
                <person name="Lorimer D.D."/>
                <person name="Horanyi P.S."/>
                <person name="Edwards T.E."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 46-559</scope>
    </reference>
    <reference evidence="17 18 21" key="4">
        <citation type="journal article" date="2019" name="Proc. Natl. Acad. Sci. U.S.A." volume="116" first="7015" last="7020">
            <title>Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.</title>
            <authorList>
                <person name="Baragana B."/>
                <person name="Forte B."/>
                <person name="Choi R."/>
                <person name="Nakazawa Hewitt S."/>
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                <person name="Brooks C.F."/>
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                <person name="Jumani R.S."/>
                <person name="Lorimer D.D."/>
                <person name="Love M.S."/>
                <person name="Maher S."/>
                <person name="Matthews H."/>
                <person name="McNamara C.W."/>
                <person name="Miller P."/>
                <person name="O'Neill S."/>
                <person name="Ojo K.K."/>
                <person name="Osuna-Cabello M."/>
                <person name="Pinto E."/>
                <person name="Post J."/>
                <person name="Riley J."/>
                <person name="Rottmann M."/>
                <person name="Sanz L.M."/>
                <person name="Scullion P."/>
                <person name="Sharma A."/>
                <person name="Shepherd S.M."/>
                <person name="Shishikura Y."/>
                <person name="Simeons F.R.C."/>
                <person name="Stebbins E.E."/>
                <person name="Stojanovski L."/>
                <person name="Straschil U."/>
                <person name="Tamaki F.K."/>
                <person name="Tamjar J."/>
                <person name="Torrie L.S."/>
                <person name="Vantaux A."/>
                <person name="Witkowski B."/>
                <person name="Wittlin S."/>
                <person name="Yogavel M."/>
                <person name="Zuccotto F."/>
                <person name="Angulo-Barturen I."/>
                <person name="Sinden R."/>
                <person name="Baum J."/>
                <person name="Gamo F.J."/>
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                <person name="Myler P.J."/>
                <person name="Wyatt P.G."/>
                <person name="Floyd D."/>
                <person name="Matthews D."/>
                <person name="Sharma A."/>
                <person name="Striepen B."/>
                <person name="Huston C.D."/>
                <person name="Gray D.W."/>
                <person name="Fairlamb A.H."/>
                <person name="Pisliakov A.V."/>
                <person name="Walpole C."/>
                <person name="Read K.D."/>
                <person name="Van Voorhis W.C."/>
                <person name="Gilbert I.H."/>
            </authorList>
            <dbReference type="PubMed" id="30894487"/>
            <dbReference type="DOI" id="10.1073/pnas.1814685116"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.46 ANGSTROMS) OF 46-559</scope>
    </reference>
    <reference evidence="22" key="5">
        <citation type="journal article" date="2022" name="ACS Infect. Dis." volume="8" first="1962" last="1974">
            <title>Toolkit of Approaches To Support Target-Focused Drug Discovery for &lt;i&gt;Plasmodium falciparum&lt;/i&gt; Lysyl tRNA Synthetase.</title>
            <authorList>
                <person name="Milne R."/>
                <person name="Wiedemar N."/>
                <person name="Corpas-Lopez V."/>
                <person name="Moynihan E."/>
                <person name="Wall R.J."/>
                <person name="Dawson A."/>
                <person name="Robinson D.A."/>
                <person name="Shepherd S.M."/>
                <person name="Smith R.J."/>
                <person name="Hallyburton I."/>
                <person name="Post J.M."/>
                <person name="Dowers K."/>
                <person name="Torrie L.S."/>
                <person name="Gilbert I.H."/>
                <person name="Baragana B."/>
                <person name="Patterson S."/>
                <person name="Wyllie S."/>
            </authorList>
            <dbReference type="PubMed" id="36037410"/>
            <dbReference type="DOI" id="10.1021/acsinfecdis.2c00364"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 46-559</scope>
    </reference>
    <reference evidence="23" key="6">
        <citation type="journal article" date="2024" name="Sci. Transl. Med." volume="16" first="eadm8631" last="eadm8631">
            <title>&amp;lt;i&amp;gt;Cryptosporidium&amp;lt;/i&amp;gt; lysyl-tRNA synthetase inhibitors define the interplay between solubility and permeability required to achieve efficacy.</title>
            <authorList>
                <person name="Caldwell N."/>
                <person name="Peet C."/>
                <person name="Miller P."/>
                <person name="Colon B.L."/>
                <person name="Taylor M.G."/>
                <person name="Cocco M."/>
                <person name="Dawson A."/>
                <person name="Lukac I."/>
                <person name="Teixeira J.E."/>
                <person name="Robinson L."/>
                <person name="Frame L."/>
                <person name="Seizova S."/>
                <person name="Damerow S."/>
                <person name="Tamaki F."/>
                <person name="Post J."/>
                <person name="Riley J."/>
                <person name="Mutter N."/>
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                <person name="Ferguson L."/>
                <person name="Hu X."/>
                <person name="Tinti M."/>
                <person name="Forte B."/>
                <person name="Norcross N.R."/>
                <person name="Campbell P.S."/>
                <person name="Svensen N."/>
                <person name="Caldwell F.C."/>
                <person name="Jansen C."/>
                <person name="Postis V."/>
                <person name="Read K.D."/>
                <person name="Huston C.D."/>
                <person name="Gilbert I.H."/>
                <person name="Baragana B."/>
                <person name="Pawlowic M.C."/>
            </authorList>
            <dbReference type="PubMed" id="39441903"/>
            <dbReference type="DOI" id="10.1126/scitranslmed.adm8631"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 46-559</scope>
    </reference>
    <reference evidence="24" key="7">
        <citation type="journal article" date="2025" name="Sci. Transl. Med." volume="17" first="eadu4564" last="eadu4564">
            <title>Antitrypanosomal quinazolines targeting lysyl-tRNA synthetase show partial efficacy in a mouse model of acute Chagas disease.</title>
            <authorList>
                <person name="Tulloch L.B."/>
                <person name="Tawell H."/>
                <person name="Taylor A.E."/>
                <person name="Lima M.L."/>
                <person name="Dawson A."/>
                <person name="Carvalho S."/>
                <person name="Wall R.J."/>
                <person name="Corpas-Lopez V."/>
                <person name="Dey G."/>
                <person name="Duggan J."/>
                <person name="Magalhaes L.G."/>
                <person name="Torrie L.S."/>
                <person name="Frame L."/>
                <person name="Robinson D."/>
                <person name="Patterson S."/>
                <person name="Tinti M."/>
                <person name="Weaver G.W."/>
                <person name="Robinson W.J."/>
                <person name="Cal M."/>
                <person name="Kaiser M."/>
                <person name="Maser P."/>
                <person name="Sjo P."/>
                <person name="Perry B."/>
                <person name="Kelly J.M."/>
                <person name="Francisco A.F."/>
                <person name="Bhambra A.S."/>
                <person name="Wyllie S."/>
            </authorList>
            <dbReference type="PubMed" id="40632837"/>
            <dbReference type="DOI" id="10.1126/scitranslmed.adu4564"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.60 ANGSTROMS) OF 46-559</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11 12">
            <text>tRNA(Lys) + L-lysine + ATP = L-lysyl-tRNA(Lys) + AMP + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:20792"/>
            <dbReference type="Rhea" id="RHEA-COMP:9696"/>
            <dbReference type="Rhea" id="RHEA-COMP:9697"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:32551"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78529"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.6" evidence="3 12"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625825.1">
        <property type="nucleotide sequence ID" value="XM_625825.1"/>
    </dbReference>
    <dbReference type="PDB" id="5ELN">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B/C/D=46-559"/>
    </dbReference>
    <dbReference type="PDB" id="5ELO">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.90 A"/>
        <property type="chains" value="A/B/C/D=46-559"/>
    </dbReference>
    <dbReference type="PDB" id="6BNI">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.85 A"/>
        <property type="chains" value="A/B=46-559"/>
    </dbReference>
    <dbReference type="PDB" id="6C86">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.15 A"/>
        <property type="chains" value="A/B=46-559"/>
    </dbReference>
    <dbReference type="PDB" id="6HCW">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.46 A"/>
        <property type="chains" value="A/B=46-559"/>
    </dbReference>
    <dbReference type="PDB" id="7ZOG">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A/B/C/D=46-559"/>
    </dbReference>
    <dbReference type="PDB" id="8S00">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.00 A"/>
        <property type="chains" value="A/B=46-559"/>
    </dbReference>
    <dbReference type="PDB" id="8S0V">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.60 A"/>
        <property type="chains" value="A/B=46-559"/>
    </dbReference>
    <dbReference type="PDBsum" id="5ELN"/>
    <dbReference type="PDBsum" id="5ELO"/>
    <dbReference type="PDBsum" id="6BNI"/>
    <dbReference type="PDBsum" id="6C86"/>
    <dbReference type="PDBsum" id="6HCW"/>
    <dbReference type="AlphaFoldDB" id="Q5CR27"/>
    <dbReference type="SMR" id="Q5CR27"/>
    <dbReference type="FunCoup" id="Q5CR27">
        <property type="interactions" value="535"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR27"/>
    <dbReference type="GeneID" id="3372887"/>
    <dbReference type="KEGG" id="cpv:cgd4_2370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2370"/>
    <dbReference type="InParanoid" id="Q5CR27"/>
    <dbReference type="OMA" id="DFRNEGM"/>
    <dbReference type="OrthoDB" id="21243at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004824">
        <property type="term" value="F:lysine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000049">
        <property type="term" value="F:tRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006430">
        <property type="term" value="P:lysyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00775">
        <property type="entry name" value="LysRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd04322">
        <property type="entry name" value="LysRS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000050">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000238">
        <property type="entry name" value="Lysine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00252">
        <property type="entry name" value="Lys_tRNA_synth_class2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004364">
        <property type="entry name" value="Aa-tRNA-synt_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002313">
        <property type="entry name" value="Lys-tRNA-ligase_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034762">
        <property type="entry name" value="Lys-tRNA-ligase_II_bac/euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044136">
        <property type="entry name" value="Lys-tRNA-ligase_II_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018149">
        <property type="entry name" value="Lys-tRNA-synth_II_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004365">
        <property type="entry name" value="NA-bd_OB_tRNA"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00499">
        <property type="entry name" value="lysS_bact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001756">
        <property type="entry name" value="PRK00484.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918:SF9">
        <property type="entry name" value="LYSINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42918">
        <property type="entry name" value="LYSYL-TRNA SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00152">
        <property type="entry name" value="tRNA-synt_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01336">
        <property type="entry name" value="tRNA_anti-codon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039101">
        <property type="entry name" value="LysRS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00982">
        <property type="entry name" value="TRNASYNTHLYS"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="17 18 19" id="KW-0002">3D-structure</keyword>
    <keyword evidence="9 15" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="13" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="13" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="13">
        <location>
            <begin position="6"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="216"/>
            <end position="541"/>
        </location>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="293"/>
        </location>
        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="297"/>
        </location>
        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="304"/>
        </location>
        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="307"/>
        </location>
        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="464"/>
        </location>
        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="19">
        <location>
            <position position="465"/>
        </location>
        <ligand>
            <name>adenosine</name>
            <dbReference type="ChEBI" id="CHEBI:16335"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013166"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00030563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00048573"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU003748"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK87861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="17">
        <source>
            <dbReference type="PDB" id="5ELN"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="5ELO"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="19">
        <source>
            <dbReference type="PDB" id="6BNI"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="20">
        <source>
            <dbReference type="PDB" id="6C86"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="21">
        <source>
            <dbReference type="PDB" id="6HCW"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="22">
        <source>
            <dbReference type="PDB" id="7ZOG"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="23">
        <source>
            <dbReference type="PDB" id="8S00"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="24">
        <source>
            <dbReference type="PDB" id="8S0V"/>
        </source>
    </evidence>
    <sequence length="559" mass="64310" checksum="E8025DECE4762665" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR84</accession>
    <name>Q5CR84_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">GPI inositol-deacylase</fullName>
            <ecNumber evidence="6">3.1.-.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_1740</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="6">Endoplasmic reticulum membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Membrane</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the GPI inositol-deacylase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.-.-" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87904.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625768.1">
        <property type="nucleotide sequence ID" value="XM_625768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR84"/>
    <dbReference type="STRING" id="353152.Q5CR84"/>
    <dbReference type="GeneID" id="3372910"/>
    <dbReference type="KEGG" id="cpv:cgd4_1740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1740"/>
    <dbReference type="InParanoid" id="Q5CR84"/>
    <dbReference type="OrthoDB" id="5086500at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016788">
        <property type="term" value="F:hydrolase activity, acting on ester bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012908">
        <property type="entry name" value="PGAP1-ab_dom-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052374">
        <property type="entry name" value="SERAC1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48182:SF2">
        <property type="entry name" value="PROTEIN SERAC1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07819">
        <property type="entry name" value="PGAP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="6" id="KW-0653">Protein transport</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0813">Transport</keyword>
    <feature type="domain" description="GPI inositol-deacylase PGAP1-like alpha/beta" evidence="7">
        <location>
            <begin position="813"/>
            <end position="927"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU365011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF07819"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87904.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1025" mass="120622" checksum="D8716F3613D9077E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR96</accession>
    <name>Q5CR96_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Spc7 kinetochore protein domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_1600</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87913.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625756.1">
        <property type="nucleotide sequence ID" value="XM_625756.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372929"/>
    <dbReference type="KEGG" id="cpv:cgd4_1600"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1600"/>
    <dbReference type="InParanoid" id="Q5CR96"/>
    <dbReference type="OMA" id="SCHISEM"/>
    <dbReference type="OrthoDB" id="342942at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="97"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="151"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="489"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="908"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="35"/>
            <end position="50"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="159"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="489"/>
            <end position="504"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87913.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1328" mass="152740" checksum="8D9956986F35CE23" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRC3</accession>
    <name>Q5CRC3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein with signal peptide and possible kazal domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_3380</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88032.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626263.1">
        <property type="nucleotide sequence ID" value="XM_626263.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRC3"/>
    <dbReference type="GeneID" id="3373052"/>
    <dbReference type="KEGG" id="cpv:cgd5_3380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3380"/>
    <dbReference type="InParanoid" id="Q5CRC3"/>
    <dbReference type="OrthoDB" id="126772at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd00104">
        <property type="entry name" value="KAZAL_FS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002350">
        <property type="entry name" value="Kazal_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036058">
        <property type="entry name" value="Kazal_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07648">
        <property type="entry name" value="Kazal_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100895">
        <property type="entry name" value="Kazal-type serine protease inhibitors"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51465">
        <property type="entry name" value="KAZAL_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254151" evidence="1">
        <location>
            <begin position="20"/>
            <end position="613"/>
        </location>
    </feature>
    <feature type="domain" description="Kazal-like" evidence="2">
        <location>
            <begin position="557"/>
            <end position="608"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88032.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="613" mass="68357" checksum="91895DFB8FF62F23" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRG7</accession>
    <name>Q5CRG7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Chorein/VPS13 like protein involved in vacuolar transport</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2830</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87994.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626219.1">
        <property type="nucleotide sequence ID" value="XM_626219.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRG7"/>
    <dbReference type="GeneID" id="3373232"/>
    <dbReference type="KEGG" id="cpv:cgd5_2830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2830"/>
    <dbReference type="InParanoid" id="Q5CRG7"/>
    <dbReference type="OMA" id="MEITWIN"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1571"/>
            <end position="1599"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87994.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2302" mass="264127" checksum="BF763D3CFBF23127" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRI6</accession>
    <name>Q5CRI6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">60S ribosomal protein L7-B Rp17bp L30 RNA binding domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_2630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87981.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626200.1">
        <property type="nucleotide sequence ID" value="XM_626200.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRI6"/>
    <dbReference type="STRING" id="353152.Q5CRI6"/>
    <dbReference type="GeneID" id="3373163"/>
    <dbReference type="KEGG" id="cpv:cgd5_2630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2630"/>
    <dbReference type="InParanoid" id="Q5CRI6"/>
    <dbReference type="OMA" id="VNGWGPQ"/>
    <dbReference type="OrthoDB" id="28644at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022625">
        <property type="term" value="C:cytosolic large ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000463">
        <property type="term" value="P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.15.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1390.20">
        <property type="entry name" value="Ribosomal protein L30, ferredoxin-like fold domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036919">
        <property type="entry name" value="Ribo_uL30_ferredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039699">
        <property type="entry name" value="Ribosomal_uL30"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11524:SF16">
        <property type="entry name" value="LARGE RIBOSOMAL SUBUNIT PROTEIN UL30"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55129">
        <property type="entry name" value="Ribosomal protein L30p/L7e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="1" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87981.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="268" mass="31026" checksum="9A05104E6C790B44" modified="2005-04-12" version="1">MEEKHILKPRNDGESLKIAEGILRRRKIVDTDRRLKYREERRKIKKELHKPEIQTLQRILKKSRNNILDKRRLKNKDKKPYLTPKKTNGRLIVLVVRNSRFCGSLESNRKLRDLGLVNKFSAVILSHTDETIRVLREVKPYVFYGFPNLNLLKTLVFKKGAFTHQNVQSKGQSRAKLSEKKQGKVLLTDNNIVEDRLGEIGVLCTEDIVTGLWNGCETQQDKEIFEAITSNLAPFQLCNLKRAEGFDAKKFESGFLGKSINEKISKII</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRL5</accession>
    <name>Q5CRL5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Possible SET domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87960.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626171.1">
        <property type="nucleotide sequence ID" value="XM_626171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRL5"/>
    <dbReference type="GeneID" id="3373123"/>
    <dbReference type="KEGG" id="cpv:cgd5_2340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2340"/>
    <dbReference type="InParanoid" id="Q5CRL5"/>
    <dbReference type="OrthoDB" id="337151at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.270.10">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001214">
        <property type="entry name" value="SET_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046341">
        <property type="entry name" value="SET_dom_sf"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00856">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82199">
        <property type="entry name" value="SET domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50280">
        <property type="entry name" value="SET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SET" evidence="2">
        <location>
            <begin position="281"/>
            <end position="409"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="427"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50280"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87960.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="524" mass="59597" checksum="B2544A10754B2C59" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRL8</accession>
    <name>Q5CRL8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Sin3 like paired amphipathic helix containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_2310</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626168.1">
        <property type="nucleotide sequence ID" value="XM_626168.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRL8"/>
    <dbReference type="GeneID" id="3373348"/>
    <dbReference type="KEGG" id="cpv:cgd5_2310"/>
    <dbReference type="InParanoid" id="Q5CRL8"/>
    <dbReference type="OMA" id="EWTHARH"/>
    <dbReference type="OrthoDB" id="10265969at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000118">
        <property type="term" value="C:histone deacetylase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000122">
        <property type="term" value="P:negative regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1160.11">
        <property type="entry name" value="Paired amphipathic helix"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013194">
        <property type="entry name" value="HDAC_interact_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003822">
        <property type="entry name" value="PAH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036600">
        <property type="entry name" value="PAH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039774">
        <property type="entry name" value="Sin3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031693">
        <property type="entry name" value="Sin3_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346:SF0">
        <property type="entry name" value="SIN3A, ISOFORM G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12346">
        <property type="entry name" value="SIN3B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02671">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08295">
        <property type="entry name" value="Sin3_corepress"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16879">
        <property type="entry name" value="Sin3a_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00761">
        <property type="entry name" value="HDAC_interact"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47762">
        <property type="entry name" value="PAH2 domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51477">
        <property type="entry name" value="PAH"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3 4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0678">Repressor</keyword>
    <feature type="domain" description="Histone deacetylase interacting" evidence="6">
        <location>
            <begin position="370"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="589"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="781"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="824"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1176"/>
            <end position="1195"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1330"/>
            <end position="1407"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="589"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="605"/>
            <end position="621"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="782"/>
            <end position="800"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="835"/>
            <end position="847"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1176"/>
            <end position="1190"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1335"/>
            <end position="1348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1380"/>
            <end position="1391"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022491"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00810"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1434" mass="162884" checksum="78177DF9BA8FA9CE" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRP4</accession>
    <name>Q5CRP4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Nuclear VCP like protein with 2 AAA ATpase domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_2010</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88236.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626142.1">
        <property type="nucleotide sequence ID" value="XM_626142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRP4"/>
    <dbReference type="STRING" id="353152.Q5CRP4"/>
    <dbReference type="GeneID" id="3373084"/>
    <dbReference type="KEGG" id="cpv:cgd5_2010"/>
    <dbReference type="InParanoid" id="Q5CRP4"/>
    <dbReference type="OMA" id="GLWSTHR"/>
    <dbReference type="OrthoDB" id="27435at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990275">
        <property type="term" value="F:preribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042254">
        <property type="term" value="P:ribosome biogenesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000149">
        <property type="entry name" value="Nuclear valosin-containing protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000365">
        <property type="entry name" value="Ribosome biogenesis ATPase RIX7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050168">
        <property type="entry name" value="AAA_ATPase_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077">
        <property type="entry name" value="AAA-FAMILY ATPASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23077:SF171">
        <property type="entry name" value="NUCLEAR VALOSIN-CONTAINING PROTEIN-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="123"/>
            <end position="258"/>
        </location>
    </feature>
    <feature type="domain" description="AAA+ ATPase" evidence="5">
        <location>
            <begin position="441"/>
            <end position="577"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="29"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88236.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="695" mass="77239" checksum="D9EE1AA78CBA0927" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRT8</accession>
    <name>Q5CRT8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_1510</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88098.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626098.1">
        <property type="nucleotide sequence ID" value="XM_626098.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRT8"/>
    <dbReference type="GeneID" id="3373024"/>
    <dbReference type="KEGG" id="cpv:cgd5_1510"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1510"/>
    <dbReference type="InParanoid" id="Q5CRT8"/>
    <dbReference type="OMA" id="GTESKFQ"/>
    <dbReference type="OrthoDB" id="339358at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="321"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="540"/>
            <end position="567"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="663"/>
            <end position="729"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88098.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="738" mass="85669" checksum="8522A38301FB910C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRY6</accession>
    <name>Q5CRY6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">C2H2-type domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_990</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88140.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626050.1">
        <property type="nucleotide sequence ID" value="XM_626050.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373127"/>
    <dbReference type="KEGG" id="cpv:cgd5_990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_990"/>
    <dbReference type="InParanoid" id="Q5CRY6"/>
    <dbReference type="OMA" id="GICHELP"/>
    <dbReference type="OrthoDB" id="431852at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000127">
        <property type="term" value="C:transcription factor TFIIIC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042791">
        <property type="term" value="P:5S class rRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006384">
        <property type="term" value="P:transcription initiation at RNA polymerase III promoter"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044210">
        <property type="entry name" value="Tfc3-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007309">
        <property type="entry name" value="TFIIIC_Bblock-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15180:SF1">
        <property type="entry name" value="GENERAL TRANSCRIPTION FACTOR 3C POLYPEPTIDE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04182">
        <property type="entry name" value="B-block_TFIIIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="2" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="C2H2-type" evidence="6">
        <location>
            <begin position="1126"/>
            <end position="1147"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88140.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1983" mass="229573" checksum="5EF7D75BD669A961" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS13</accession>
    <name>Q5CS13_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">RuvB-like helicase</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd5_670</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="16">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12">Belongs to the RuvB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88159.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626023.1">
        <property type="nucleotide sequence ID" value="XM_626023.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS13"/>
    <dbReference type="FunCoup" id="Q5CS13">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS13"/>
    <dbReference type="GeneID" id="3373166"/>
    <dbReference type="KEGG" id="cpv:cgd5_670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_670"/>
    <dbReference type="InParanoid" id="Q5CS13"/>
    <dbReference type="OMA" id="IINTEPY"/>
    <dbReference type="OrthoDB" id="10060499at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="RHEA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003678">
        <property type="term" value="F:DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:002221">
        <property type="entry name" value="RuvB-like 2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000010">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.360:FF:000002">
        <property type="entry name" value="RuvB-like helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.360">
        <property type="entry name" value="RuvB-like helicase, domain II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027238">
        <property type="entry name" value="RuvB-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041048">
        <property type="entry name" value="RuvB-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042487">
        <property type="entry name" value="RuvBL1/2_DNA/RNA_bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010339">
        <property type="entry name" value="TIP49_P-loop"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11093">
        <property type="entry name" value="RUVB-RELATED REPTIN AND PONTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06068">
        <property type="entry name" value="TIP49"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17856">
        <property type="entry name" value="TIP49_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11 12" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 12" id="KW-0804">Transcription</keyword>
    <keyword evidence="8 12" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="13">
        <location>
            <begin position="65"/>
            <end position="358"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU363048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK88159.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="479" mass="53632" checksum="1F62D6E1CF291665" modified="2005-04-12" version="1">MIEPKIAEIKEFQRLERIGAHSHIRGLGLNDALDARYSSDGMVGQKLARRAAGIIVRMVKQGKIAGRAILLSGQPGTGKTAIAMAIAKAIGSDTPFTHISASEVFSLEMNKTEALRQALRRSIGVRIKEEIDVIEGEVAELEIDRSNTTGVKVGRMALRSTDMETVYDIGSKMIESLQAENIVAGDVISINKSSGKITKLGRSFTRSKDYDAVGYQTRFIACPEGELQKKREVVHNVTLHDIDVINSRTQGFLALFAGDTGEIKPEVRAQIDEKVAEWKEESRAEIVHGVLFIDEVHMLDVECFSFLNKALEEETSPILIMASNRGITKIRGTDYKSPHGIPIDLLDRCLIIPTVPYSEEDVKKIIQERASEEDLKLTDSAYQILTRIAMDTSLRYSLHLLTVSQVLANRKKKEEIDLDEIKKAYSLFIDVKRSTQYLIDYQQEYLFSEIEHSNNDVKDKDNGNDTMRDTAVQEKMTLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS39</accession>
    <name>Q5CS39_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_350</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88178.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625997.1">
        <property type="nucleotide sequence ID" value="XM_625997.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS39"/>
    <dbReference type="GeneID" id="3373185"/>
    <dbReference type="KEGG" id="cpv:cgd5_350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_350"/>
    <dbReference type="InParanoid" id="Q5CS39"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="184"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="184"/>
            <end position="196"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88178.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="236" mass="26170" checksum="C347DD1EE75C4646" modified="2005-04-12" version="1">MTIDSSSSSSSSSSTTTTTTTTTTTTTTTTTTTTTTTTTRNHIFISSSTTLKPKLSIGSCHDSNMSVCVNGKCGNPKNLWSSCHTNRTRHLGEDEEVNVNTGNNNEIQIEWIDLNNEPKVFKDSKGNIYYNVDGFVDNTITNSTELSNQESKSHEVSNNNMCVEDHVCACMMEGLVEEDITVIDGDEDDNDDDSEPINDNKVNNETKSVGFDRIQSKYDKKSLLEKWLDLKKIYES</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS96</accession>
    <name>Q5CS96_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_3590</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88299.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628171.1">
        <property type="nucleotide sequence ID" value="XM_628171.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS96"/>
    <dbReference type="GeneID" id="3371570"/>
    <dbReference type="KEGG" id="cpv:cgd1_3590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3590"/>
    <dbReference type="InParanoid" id="Q5CS96"/>
    <dbReference type="OMA" id="ATHKWHE"/>
    <dbReference type="OrthoDB" id="342230at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="89"/>
            <end position="110"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="216"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="430"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="231"/>
            <end position="248"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88299.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="445" mass="50182" checksum="4371F48C6D92A809" modified="2005-04-12" version="1">MVQMNNKGILDGIELREGGIKVDQSLERVNKGHTGLGADAGSLKDESKQVLNARRGLVRMIIDIILGKDTTKQYKEGSAAYFIDKIQKILRLISLIFSLFILGFIITSRINKGRKDISSSFPVGSLGRSVKFEMMLDTLENERGKLSGEGLFGERSKVNDKGIDGKDVKGQNTDYDENLEEFNSQVLDDPEYWADDNDKDLWDDDIDEYYDMEIVSSEDDENDEELANNNTSKENSNTIPNESSSQIIQGKRNKGLRSKGVEISLPSSLILYGRVTKEDTYINGAYNIIIEEKKDGKKYPKLHHGRAIYKKEGKTNGNATTPTLFIIFDGTHEFWTITSSLDPGLKPLAFLPDHALIPIRHVGPYGAHSNSTWVFRNNNGILKDSSVRIVENSSVDFPRIPVHITKATHNWHVKHHRETKGRTNSNKKNVSNYNTDLKVFKDPYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSB1</accession>
    <name>Q5CSB1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="13">Crossover junction endonuclease MUS81</fullName>
            <ecNumber evidence="13">3.1.22.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd1_3420</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="13">Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).</text>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1 13">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="13">Interacts with EME1.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 13">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 13">Belongs to the XPF family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.22.-" evidence="13"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628156.1">
        <property type="nucleotide sequence ID" value="XM_628156.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSB1"/>
    <dbReference type="STRING" id="353152.Q5CSB1"/>
    <dbReference type="GeneID" id="3371584"/>
    <dbReference type="KEGG" id="cpv:cgd1_3420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3420"/>
    <dbReference type="InParanoid" id="Q5CSB1"/>
    <dbReference type="OMA" id="YLRICEN"/>
    <dbReference type="OrthoDB" id="5963188at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048476">
        <property type="term" value="C:Holliday junction resolvase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048257">
        <property type="term" value="F:3'-flap endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006308">
        <property type="term" value="P:DNA catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031573">
        <property type="term" value="P:mitotic intra-S DNA damage checkpoint signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000712">
        <property type="term" value="P:resolution of meiotic recombination intermediates"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd20074">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.670">
        <property type="entry name" value="Crossover junction endonuclease EME1, DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.110">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027421">
        <property type="entry name" value="DNA_pol_lamdba_lyase_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042530">
        <property type="entry name" value="EME1/EME2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006166">
        <property type="entry name" value="ERCC4_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033309">
        <property type="entry name" value="Mus81"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011335">
        <property type="entry name" value="Restrct_endonuc-II-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047416">
        <property type="entry name" value="XPF_nuclease_Mus81"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451">
        <property type="entry name" value="CLASS II CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13451:SF0">
        <property type="entry name" value="CROSSOVER JUNCTION ENDONUCLEASE MUS81"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02732">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00891">
        <property type="entry name" value="ERCC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47802">
        <property type="entry name" value="DNA polymerase beta, N-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52980">
        <property type="entry name" value="Restriction endonuclease-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 13" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10 13" id="KW-0233">DNA recombination</keyword>
    <keyword evidence="11 13" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6 13 16" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8 13" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 13" id="KW-0460">Magnesium</keyword>
    <keyword evidence="5 13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 13" id="KW-0540">Nuclease</keyword>
    <keyword evidence="12 13" id="KW-0539">Nucleus</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="ERCC4" evidence="15">
        <location>
            <begin position="366"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="14">
        <location>
            <begin position="15"/>
            <end position="43"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="14">
        <location>
            <begin position="15"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="14">
        <location>
            <begin position="32"/>
            <end position="41"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023172"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU369042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="SMART" id="SM00891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK88313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="734" mass="86331" checksum="7DA7AE72AE774B96" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSC6</accession>
    <name>Q5CSC6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal peptide, possible transmembrane domain near N-terminus, proline rich and His-stretch at C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_3250</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88324.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628141.1">
        <property type="nucleotide sequence ID" value="XM_628141.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSC6"/>
    <dbReference type="GeneID" id="3371458"/>
    <dbReference type="KEGG" id="cpv:cgd1_3250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3250"/>
    <dbReference type="InParanoid" id="Q5CSC6"/>
    <dbReference type="OrthoDB" id="342412at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="30"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254326" evidence="3">
        <location>
            <begin position="31"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="61"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="125"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="138"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="160"/>
            <end position="177"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88324.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="241" mass="27506" checksum="51E1B4333F099389" modified="2005-04-12" version="1">MFNMINLKLHTTRFLILVLVILSNIGELLSQDVETENKSSRYDHIVDQIYYNRYHSNNAKYLVWLLVLVPVFICIPCLIWVWCSDHCLQILKYRSNMKVFKEKKLMNEIILTNLSDNILNKELNGSNSSLPSMGVPHSMPPPIPHPPQPQFHPQMGGVMPQPPPMPQPPPMPQPQPSSHPQILSQPIIGGPQQNPILPTHIQPSPSYIPNLHISRPPNMELPQLVQQDHAHHHHHCGFNGH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSD2</accession>
    <name>Q5CSD2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_3190</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88329.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628135.1">
        <property type="nucleotide sequence ID" value="XM_628135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSD2"/>
    <dbReference type="GeneID" id="3371463"/>
    <dbReference type="KEGG" id="cpv:cgd1_3190"/>
    <dbReference type="InParanoid" id="Q5CSD2"/>
    <dbReference type="OMA" id="ALEWDIN"/>
    <dbReference type="OrthoDB" id="343388at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88329.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="741" mass="85156" checksum="78EC51B20682B0F7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSM1</accession>
    <name>Q5CSM1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein phosphatase regulator like heat repeats</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88394.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628046.1">
        <property type="nucleotide sequence ID" value="XM_628046.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSM1"/>
    <dbReference type="STRING" id="353152.Q5CSM1"/>
    <dbReference type="GeneID" id="3371684"/>
    <dbReference type="KEGG" id="cpv:cgd1_2120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2120"/>
    <dbReference type="InParanoid" id="Q5CSM1"/>
    <dbReference type="OMA" id="RYCCILL"/>
    <dbReference type="OrthoDB" id="340346at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000159">
        <property type="term" value="C:protein phosphatase type 2A complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019888">
        <property type="term" value="F:protein phosphatase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051023">
        <property type="entry name" value="PP2A_Regulatory_Subunit_A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648:SF4">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2 (FORMERLY 2A), REGULATORY SUBUNIT A, BETA ISOFORM-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10648">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN PHOSPHATASE PP2A 65 KDA REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88394.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="929" mass="107038" checksum="1A811C10675A1A17" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSS4</accession>
    <name>Q5CSS4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Rpn5 like 26S proteasomal regulatory subunit 12, PINT domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1530</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88438.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627993.1">
        <property type="nucleotide sequence ID" value="XM_627993.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSS4"/>
    <dbReference type="FunCoup" id="Q5CSS4">
        <property type="interactions" value="555"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSS4"/>
    <dbReference type="GeneID" id="3371611"/>
    <dbReference type="KEGG" id="cpv:cgd1_1530"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1530"/>
    <dbReference type="InParanoid" id="Q5CSS4"/>
    <dbReference type="OMA" id="AENEMFK"/>
    <dbReference type="OrthoDB" id="268763at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008541">
        <property type="term" value="C:proteasome regulatory particle, lid subcomplex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054559">
        <property type="entry name" value="PSMD12-CSN4-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040134">
        <property type="entry name" value="PSMD12/CSN4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10855">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 12/COP9 SIGNALOSOME COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22241">
        <property type="entry name" value="PSMD12-CSN4_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="1">
        <location>
            <begin position="344"/>
            <end position="518"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88438.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="559" mass="65614" checksum="AF002E7DECDD36C5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CST3</accession>
    <name>Q5CST3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_1430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88448.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627984.1">
        <property type="nucleotide sequence ID" value="XM_627984.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CST3"/>
    <dbReference type="GeneID" id="3371621"/>
    <dbReference type="KEGG" id="cpv:cgd1_1430"/>
    <dbReference type="InParanoid" id="Q5CST3"/>
    <dbReference type="OrthoDB" id="341774at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254344" evidence="1">
        <location>
            <begin position="23"/>
            <end position="117"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88448.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="117" mass="13867" checksum="61CD6D52F20D27D3" modified="2005-04-12" version="1">MLINRWVIFAYLFQLLWRYIISEGTQINAATEENDAYRYNIIADDLLNMDFPAYKFRDLKRKSRVIIEANNRMLHVLEDLLIISDEILEGFSDPSKEPYFLEEYKSISLVSLILNVI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSU2</accession>
    <name>Q5CSU2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Cleavage stimulation factor subunit 2 that has a CSF1 like RRM domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_1310</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627975.1">
        <property type="nucleotide sequence ID" value="XM_627975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSU2"/>
    <dbReference type="STRING" id="353152.Q5CSU2"/>
    <dbReference type="GeneID" id="3371363"/>
    <dbReference type="KEGG" id="cpv:cgd1_1310"/>
    <dbReference type="InParanoid" id="Q5CSU2"/>
    <dbReference type="OMA" id="IETCIMA"/>
    <dbReference type="OrthoDB" id="272703at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005847">
        <property type="term" value="C:mRNA cleavage and polyadenylation specificity factor complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12398">
        <property type="entry name" value="RRM_CSTF2_RNA15_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025742">
        <property type="entry name" value="CSTF2_hinge"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031721">
        <property type="entry name" value="Partial_CstF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45735:SF2">
        <property type="entry name" value="CLEAVAGE STIMULATION FACTOR SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14327">
        <property type="entry name" value="CSTF2_hinge"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF15861">
        <property type="entry name" value="partial_CstF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="2">
        <location>
            <begin position="2"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="304" mass="33633" checksum="414667F109C9CA72" modified="2005-04-12" version="1" fragment="single">NNLSLVGNVPFDATEDELREVMNSAGPVLSMRIVHDKDTGLSRGFSFCEYRDIETCIMAIKSLNGYELRGRSIRVDWASQDMRSRYNHLVVNNTSGTAPVTATTQGGIGMGQQGTEGLHHPISLTAPSHVQQIQEDGTSMPSIPNNNANFDNISSEIIQLVQGMTVSQLYYLIGHMQKLVVQNPETARSILLDNPQFCYALLHSQFILGMVNEPFVPLNQEQLNKANEIRTKVLTLRNENSNINIKNLGEDVSVLIEEIANNPNPALLQALASIQPNSVAQWTEEEKSKILAIQQALKNRGLIN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT88</accession>
    <name>Q5CT88_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein with signal peptide, ER retention motif and 4x EF hands</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd2_3990</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88636.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626581.1">
        <property type="nucleotide sequence ID" value="XM_626581.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT88"/>
    <dbReference type="FunCoup" id="Q5CT88">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CT88"/>
    <dbReference type="GeneID" id="3373394"/>
    <dbReference type="KEGG" id="cpv:cgd2_3990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3990"/>
    <dbReference type="InParanoid" id="Q5CT88"/>
    <dbReference type="OMA" id="MPMKYAD"/>
    <dbReference type="OrthoDB" id="26525at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827:SF85">
        <property type="entry name" value="CALCIUM-BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10827">
        <property type="entry name" value="RETICULOCALBIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13202">
        <property type="entry name" value="EF-hand_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13833">
        <property type="entry name" value="EF-hand_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0106">Calcium</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253818" evidence="3">
        <location>
            <begin position="26"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="55"/>
            <end position="90"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="91"/>
            <end position="126"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="4">
        <location>
            <begin position="134"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="325"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="417"/>
            <end position="449"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="418"/>
            <end position="437"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88636.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="449" mass="51328" checksum="F31B27A5CC2F18A8" modified="2005-04-12" version="1">MKSLKLVLTTFLVLTLSLLAGFVFGTNENPNFLRLVSDKKMYDEWLKTMTVSEEIILERFGSLLEIIDLDKNGLLEKDELIKWIKFVSERSSLKEVEAEFRILDKNKDGKLSNEEFINHFVSEKDESSNKEITELNNFYRELFKEVDTDKDGYLTVGEYYYLTNYYSLSKELFVKINSFLSQNDKNGDGIIDIEEIKQIQKDNAEVITNDSGKLVVFGVDVSGEKELSVKKIIFLLRSQEIQDAITEAYNQLIDVYNTRKDAKPEDSKSSSIPIDFVRSNYVIYIQSILTDYGDVFKYPHDIFVGVDNKDYDLSKEKCTELFGENEKFSEKSDEENEFDTDEFDTDDNNPNDDVEISDDMIQKLISLMGNSGLGDMDDKGGSMFDVFASKAEGAEGGDLAGMEEILKMLQSLIGSKMGENDHIPDENETLIPDHEDNQEFPSLEARDEL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT95</accession>
    <name>Q5CT95_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_3900</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626574.1">
        <property type="nucleotide sequence ID" value="XM_626574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT95"/>
    <dbReference type="GeneID" id="3373400"/>
    <dbReference type="KEGG" id="cpv:cgd2_3900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3900"/>
    <dbReference type="InParanoid" id="Q5CT95"/>
    <dbReference type="OMA" id="DYDNIKS"/>
    <dbReference type="OrthoDB" id="343953at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="918"/>
            <end position="949"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="973"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1095"/>
            <end position="1120"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1158"/>
            <end position="1187"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="397"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="514"/>
            <end position="618"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="825"/>
            <end position="879"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="918"/>
            <end position="946"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="975"/>
            <end position="996"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1165"/>
            <end position="1187"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1241" mass="145602" checksum="F115A2F26D93E44F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTC0</accession>
    <name>Q5CTC0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">F-box domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_3620</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88665.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626549.1">
        <property type="nucleotide sequence ID" value="XM_626549.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTC0"/>
    <dbReference type="GeneID" id="3373622"/>
    <dbReference type="KEGG" id="cpv:cgd2_3620"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3620"/>
    <dbReference type="InParanoid" id="Q5CTC0"/>
    <dbReference type="OMA" id="HMSHINT"/>
    <dbReference type="OrthoDB" id="20669at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036047">
        <property type="entry name" value="F-box-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001810">
        <property type="entry name" value="F-box_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81383">
        <property type="entry name" value="F-box domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50181">
        <property type="entry name" value="FBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="F-box" evidence="1">
        <location>
            <begin position="6"/>
            <end position="53"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88665.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="956" mass="110349" checksum="46C5EC21A3CE9BB9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTI9</accession>
    <name>Q5CTI9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">THUMP RNA binding domain containing protein, Yg1232wp-like</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_2800</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88727.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626480.1">
        <property type="nucleotide sequence ID" value="XM_626480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTI9"/>
    <dbReference type="STRING" id="353152.Q5CTI9"/>
    <dbReference type="GeneID" id="3373471"/>
    <dbReference type="KEGG" id="cpv:cgd2_2800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2800"/>
    <dbReference type="InParanoid" id="Q5CTI9"/>
    <dbReference type="OMA" id="ICSELIW"/>
    <dbReference type="OrthoDB" id="367221at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006400">
        <property type="term" value="P:tRNA modification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11717">
        <property type="entry name" value="THUMP_THUMPD1_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2300.10">
        <property type="entry name" value="THUMP superfamily"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004114">
        <property type="entry name" value="THUMP_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040183">
        <property type="entry name" value="THUMPD1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452">
        <property type="entry name" value="THUMP DOMAIN CONTAINING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13452:SF10">
        <property type="entry name" value="THUMP DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143437">
        <property type="entry name" value="THUMP domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51165">
        <property type="entry name" value="THUMP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="THUMP" evidence="2">
        <location>
            <begin position="136"/>
            <end position="264"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00529"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51165"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88727.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="280" mass="32092" checksum="EA99948D710E84FD" modified="2005-04-12" version="1">MNKKRKYFPVGKSNNSRSGIPDLRILNKGILMSITVNNKSIAAYRDISRILLSNSEYNEQESPNYPNDDLTIEESIELETKKFKKDNSRFKLIDNISRCLVLIQFNDSNDKPSALVEKLMKSAYEHRTQENRGKSEIDSGCLLSSRYISRLVPLDIICSAKLDEIHKNMKALILSSFNNAFCSESEFGKETSCASWACYYNSRYSGSDIKRQEIYDLASELIWGPEDGPKYQEYKKLYPVDLGNPSKSILVEITRSFCGISIVCNYHKYCKFNLNRISSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTK3</accession>
    <name>Q5CTK3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2640</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88738.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626466.1">
        <property type="nucleotide sequence ID" value="XM_626466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTK3"/>
    <dbReference type="GeneID" id="3373636"/>
    <dbReference type="KEGG" id="cpv:cgd2_2640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2640"/>
    <dbReference type="InParanoid" id="Q5CTK3"/>
    <dbReference type="OMA" id="CCTWRIK"/>
    <dbReference type="OrthoDB" id="337694at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88738.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="185" mass="21179" checksum="3A6FA892A4C2BBB1" modified="2005-04-12" version="1">MYECTDICSQREVRLSIFPEKYPEKRKISEEIQTENIELQTDWSTKCCCTSRVKFSDTDIQEDATIEGEGNSGGQIIDEIANVISNYRRDSVLNTISEFEKKLLTIGMAEELSPENSDTEGSEYGELNIRRHSELAFKPLVLSAVENRRATAPDNMKRKIIDQLKIQINEDNTEELRSNQIPPNN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTM4</accession>
    <name>Q5CTM4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Yd1036cp-like RluD, S4+type 1 pseudouridine synthase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_2420</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88757.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626445.1">
        <property type="nucleotide sequence ID" value="XM_626445.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTM4"/>
    <dbReference type="STRING" id="353152.Q5CTM4"/>
    <dbReference type="GeneID" id="3373501"/>
    <dbReference type="KEGG" id="cpv:cgd2_2420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2420"/>
    <dbReference type="InParanoid" id="Q5CTM4"/>
    <dbReference type="OMA" id="LNSLTHM"/>
    <dbReference type="OrthoDB" id="424794at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000455">
        <property type="term" value="P:enzyme-directed rRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00165">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2350.10">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006224">
        <property type="entry name" value="PsdUridine_synth_RluA-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006145">
        <property type="entry name" value="PsdUridine_synth_RsuA/RluA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050188">
        <property type="entry name" value="RluA_PseudoU_synthase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600">
        <property type="entry name" value="MITOCHONDRIAL RNA PSEUDOURIDINE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21600:SF40">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE RPUSD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00849">
        <property type="entry name" value="PseudoU_synth_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01129">
        <property type="entry name" value="PSI_RLU"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50889">
        <property type="entry name" value="S4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Pseudouridine synthase RsuA/RluA-like" evidence="2">
        <location>
            <begin position="134"/>
            <end position="330"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00182"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00849"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88757.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="481" mass="55218" checksum="56695E30D5F9E29B" modified="2005-04-12" version="1">MNSNNTFTIYSELNVEISSSDAKTLKIIKKNYNDKEVEDYVVVVPPYMFEYESFCKLRWRDRTLRDLFLNEFRTRPIEEYLRLIDQRRLSVNDTPVNSLDYIVRNGDKIKHRSLFIELPVAIDKVKILYDSSTLLAVFKPCGIPCHPQGRFNKLSLTKLIQSEYLSKLNTNSTYIHPINRLDRVTSGLVLLSKDSSTTKNLSSKVQFAHKYYLAMINESTSNFISHISQSSIEGVSIRELSLDESHGITSHVIKCEIGLKTLKDREGESLITRIDSSENSKYSLTYFFPLISCLDINEAKKQKINETDKYSILLCKPITGRTHQIRAHLKYIGFPIVRDILYSDKVLPGTKLNTSSFKFTDSNLSARCIYNIKDLEVEELLEFPLQKKYFGGGGSMSLDSSDGLAHVEYFVEPPIGICLHSLLYILPPSVPTEKYLIFKCEVLPDWIAKNTNLNIARVLEDWPYWNKSILSELKNNKLGLL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTS3</accession>
    <name>Q5CTS3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">mannose-1-phosphate guanylyltransferase</fullName>
            <ecNumber evidence="3">2.7.7.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd2_1770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the transferase hexapeptide repeat family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.13" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88798.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626396.1">
        <property type="nucleotide sequence ID" value="XM_626396.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTS3"/>
    <dbReference type="FunCoup" id="Q5CTS3">
        <property type="interactions" value="94"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTS3"/>
    <dbReference type="GeneID" id="3373739"/>
    <dbReference type="KEGG" id="cpv:cgd2_1770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1770"/>
    <dbReference type="InParanoid" id="Q5CTS3"/>
    <dbReference type="OMA" id="GPNCWIC"/>
    <dbReference type="OrthoDB" id="1733332at2759"/>
    <dbReference type="UniPathway" id="UPA00126">
        <property type="reaction ID" value="UER00930"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004475">
        <property type="term" value="F:mannose-1-phosphate guanylyltransferase (GTP) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009298">
        <property type="term" value="P:GDP-mannose biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="CDD" id="cd06425">
        <property type="entry name" value="M1P_guanylylT_B_like_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.550.10:FF:000013">
        <property type="entry name" value="mannose-1-phosphate guanyltransferase beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.10.10">
        <property type="entry name" value="Hexapeptide repeat proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056729">
        <property type="entry name" value="GMPPB_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045233">
        <property type="entry name" value="GMPPB_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050486">
        <property type="entry name" value="Mannose-1P_guanyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005835">
        <property type="entry name" value="NTP_transferase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22572">
        <property type="entry name" value="SUGAR-1-PHOSPHATE GUANYL TRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25087">
        <property type="entry name" value="GMPPB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00483">
        <property type="entry name" value="NTP_transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Nucleotidyl transferase" evidence="7">
        <location>
            <begin position="31"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="Mannose-1-phosphate guanyltransferase C-terminal" evidence="8">
        <location>
            <begin position="314"/>
            <end position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004823"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012387"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF00483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF25087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK88798.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="425" mass="47610" checksum="2B4F4C87183EC835" modified="2005-04-12" version="1">MRFFIATEPHIFSPLNSIQFKISRYFLEVMKAIILSGGYGSRLRPLTLTKPKSIVELCNIPIIEFQIAQFASIGITEIIVALNYKANELIPTLKIIEDRYAVKVHLSIEEKPLGTAGPIKLAQDFLKEDEPFFVCNSDIICNFPLREMLDLYHKKNSDSECNGVILIKQVSDPSKFGVVLHDENTLIVEKFIEKPKDFVGDFINAGIYILSKRILDLIKPNQQVSIEKDVFPIMASSNTLYCNKFFTNNDNIWADIGNPKDFLLGSKLFMEFLKSNSITGHLCNDKHSSKTELLRKLLNENKLELSFETPELRIIGNVIVHPTSSIGKDCSIGPNVVIGKNCKIGDGVRLKDCVIFDNTNINSYSIISGSIIGCYCNIGKWTRIDGLSVFGDDVNIQDELFINSSTILPNKSVTTSINTPNTICL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTV8</accession>
    <name>Q5CTV8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1380</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88830.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626361.1">
        <property type="nucleotide sequence ID" value="XM_626361.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTV8"/>
    <dbReference type="GeneID" id="3373573"/>
    <dbReference type="KEGG" id="cpv:cgd2_1380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1380"/>
    <dbReference type="InParanoid" id="Q5CTV8"/>
    <dbReference type="OrthoDB" id="342670at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88830.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="294" mass="34356" checksum="6DCA9CE17C697D35" modified="2005-04-12" version="1">MNDKFLQKANRNDSLIEFVRYILSSRSSSFPKLSLPELHRDSELPPFFKVEKLMFERHERENKKIKFFNKCLQIAPLYPEKCNKRVAFRYHNRQPEKFSHFNLSNKKSNLSLNQKANLNGNSGSGLMCKSITPLRERICLACRKNSLLRHNNQKKNKYTEKNQNLILDYSKATMHDNKMFAMNELFQKLLNTNSAILNSVFEEDKKAMEPFRRTGDSLKINNCISKNVINDNLADSQIKEMFQQMSISLNNSEINEESHSQHSMKKYLQLLNTDPITLKNKSLATILSIERLSI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTX1</accession>
    <name>Q5CTX1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1230</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88840.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626348.1">
        <property type="nucleotide sequence ID" value="XM_626348.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTX1"/>
    <dbReference type="GeneID" id="3373583"/>
    <dbReference type="KEGG" id="cpv:cgd2_1230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1230"/>
    <dbReference type="InParanoid" id="Q5CTX1"/>
    <dbReference type="OMA" id="INWNTIT"/>
    <dbReference type="OrthoDB" id="339601at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88840.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="750" mass="86426" checksum="6F9D8F1ED115968F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTY5</accession>
    <name>Q5CTY5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="31">Calcium-dependent protein kinase 1</fullName>
            <ecNumber evidence="6">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="36" type="ORF">cgd2_1060</name>
    </gene>
    <organism evidence="36 37">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="36 37" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="37">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="29">Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase. During the liver stage, involved in sporozoite motility and thus in sporozoite invasion of host hepatocytes, probably together with CDPK4 and CDPK5. In the mosquito midgut and during the last stage of male gamete exflagellation, may play a role in the rupture of the host erythrocyte membrane. In the mosquito midgut, required for the differentiation of the zygote into the ookinete by promoting the translational activation of a subset of repressed mRNAs; these mRNAs are kept repressed in the zygote by the DOZI- or CITH-containing mRNP complexes. Dispensable during the asexual blood stage.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="28">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="27">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subunit">
        <text evidence="5">Monomer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cell membrane</location>
            <topology evidence="3">Lipid-anchor</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Cell projection</location>
            <location evidence="2">Cilium</location>
            <location evidence="2">Flagellum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="4">Host cell membrane</location>
            <topology evidence="4">Lipid-anchor</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="30">Parasitophorous vacuole membrane</location>
            <topology evidence="30">Lipid-anchor</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="26">Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="36">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88852.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626334.1">
        <property type="nucleotide sequence ID" value="XM_626334.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTY5"/>
    <dbReference type="SMR" id="Q5CTY5"/>
    <dbReference type="FunCoup" id="Q5CTY5">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTY5"/>
    <dbReference type="BindingDB" id="Q5CTY5"/>
    <dbReference type="GeneID" id="3373595"/>
    <dbReference type="KEGG" id="cpv:cgd2_1060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1060"/>
    <dbReference type="InParanoid" id="Q5CTY5"/>
    <dbReference type="OMA" id="YMTTRVG"/>
    <dbReference type="OrthoDB" id="40902at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020002">
        <property type="term" value="C:host cell plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031514">
        <property type="term" value="C:motile cilium"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0020005">
        <property type="term" value="C:symbiont-containing vacuole membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005509">
        <property type="term" value="F:calcium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00051">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="CDD" id="cd05117">
        <property type="entry name" value="STKc_CAMK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.510.10:FF:000398">
        <property type="entry name" value="Calcium-dependent protein kinase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000315">
        <property type="entry name" value="Calcium-dependent protein kinase 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.238.10:FF:000003">
        <property type="entry name" value="Calmodulin A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050205">
        <property type="entry name" value="CDPK_Ser/Thr_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018247">
        <property type="entry name" value="EF_Hand_1_Ca_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002048">
        <property type="entry name" value="EF_hand_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24349">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13499">
        <property type="entry name" value="EF-hand_7"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00054">
        <property type="entry name" value="EFh"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00018">
        <property type="entry name" value="EF_HAND_1"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50222">
        <property type="entry name" value="EF_HAND_2"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="18 32" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="17" id="KW-0106">Calcium</keyword>
    <keyword evidence="7" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="24" id="KW-0966">Cell projection</keyword>
    <keyword evidence="21" id="KW-0969">Cilium</keyword>
    <keyword evidence="19" id="KW-0282">Flagellum</keyword>
    <keyword evidence="8" id="KW-1032">Host cell membrane</keyword>
    <keyword evidence="20" id="KW-1043">Host membrane</keyword>
    <keyword evidence="16 36" id="KW-0418">Kinase</keyword>
    <keyword evidence="25" id="KW-0449">Lipoprotein</keyword>
    <keyword evidence="22" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12" id="KW-0519">Myristate</keyword>
    <keyword evidence="15 32" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="23" id="KW-0564">Palmitate</keyword>
    <keyword evidence="10" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="37" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="14" id="KW-0677">Repeat</keyword>
    <keyword evidence="9" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="34">
        <location>
            <begin position="201"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="35">
        <location>
            <begin position="569"/>
            <end position="604"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="35">
        <location>
            <begin position="605"/>
            <end position="640"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="35">
        <location>
            <begin position="641"/>
            <end position="676"/>
        </location>
    </feature>
    <feature type="domain" description="EF-hand" evidence="35">
        <location>
            <begin position="684"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="27"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="33">
        <location>
            <begin position="153"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="33">
        <location>
            <begin position="153"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="binding site" evidence="32">
        <location>
            <position position="230"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004230"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004342"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004425"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00011245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022511"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00022837"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="ARBA" id="ARBA00022846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="20">
        <source>
            <dbReference type="ARBA" id="ARBA00022870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="21">
        <source>
            <dbReference type="ARBA" id="ARBA00023069"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="22">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="23">
        <source>
            <dbReference type="ARBA" id="ARBA00023139"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="24">
        <source>
            <dbReference type="ARBA" id="ARBA00023273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="25">
        <source>
            <dbReference type="ARBA" id="ARBA00023288"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="26">
        <source>
            <dbReference type="ARBA" id="ARBA00024334"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="27">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="28">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="29">
        <source>
            <dbReference type="ARBA" id="ARBA00056933"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="30">
        <source>
            <dbReference type="ARBA" id="ARBA00060437"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="31">
        <source>
            <dbReference type="ARBA" id="ARBA00068067"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="32">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="33">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="34">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="35">
        <source>
            <dbReference type="PROSITE" id="PS50222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="36">
        <source>
            <dbReference type="EMBL" id="EAK88852.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="37">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="718" mass="80612" checksum="712ECA7240B94F17" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTY8</accession>
    <name>Q5CTY8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Bruno-like, RRM domain RNA binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd2_1000</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88855.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626331.1">
        <property type="nucleotide sequence ID" value="XM_626331.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTY8"/>
    <dbReference type="GeneID" id="3373598"/>
    <dbReference type="KEGG" id="cpv:cgd2_1000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1000"/>
    <dbReference type="InParanoid" id="Q5CTY8"/>
    <dbReference type="OMA" id="PRENNQH"/>
    <dbReference type="OrthoDB" id="410044at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00590">
        <property type="entry name" value="RRM_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24012">
        <property type="entry name" value="RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="327"/>
            <end position="406"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="556"/>
            <end position="575"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88855.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="639" mass="72091" checksum="D2A097A2CF5FF30B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU39</accession>
    <name>Q5CU39_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Dbr1p-like RNA lariat debranching enzyme</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd3_4330</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="3">
            <name>Fe(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29033"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="2">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the lariat debranching enzyme family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89231.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626975.1">
        <property type="nucleotide sequence ID" value="XM_626975.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU39"/>
    <dbReference type="STRING" id="353152.Q5CU39"/>
    <dbReference type="GeneID" id="3374005"/>
    <dbReference type="KEGG" id="cpv:cgd3_4330"/>
    <dbReference type="InParanoid" id="Q5CU39"/>
    <dbReference type="OMA" id="TDYGDWK"/>
    <dbReference type="OrthoDB" id="407609at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008419">
        <property type="term" value="F:RNA lariat debranching enzyme activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00844">
        <property type="entry name" value="MPP_Dbr1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041816">
        <property type="entry name" value="Dbr1_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849:SF0">
        <property type="entry name" value="LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12849">
        <property type="entry name" value="RNA LARIAT DEBRANCHING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0408">Iron</keyword>
    <keyword evidence="10" id="KW-0464">Manganese</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Calcineurin-like phosphoesterase" evidence="11">
        <location>
            <begin position="1"/>
            <end position="239"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00001954"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00006045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00149"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89231.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="369" mass="43156" checksum="62FA3CF1A8976905" modified="2005-04-12" version="1" fragment="single">VAVIGCCHGELNRLYMEVEKYENEKNEKVDLILCCGDMQTIRDENDLQDMAVKSHRSKKGDFWEYYEGLKKAPKLTIFIGGNHETPNVLIPLYYGGWVAPNIFYLGSSGVIRVGDVRVAGISGIYKNYDHFRGYYESKPFTEESKRSWYHIRWLEIQKLLLIENIKSNFLGSTESRKVDVMISHDWPNGIERFGNLNYLIRRKPYLKEDIELGRLGIPGCIELIEHLRPTFWFSGHHHCFFDASIEFENQLYSSEFRAIDKFKNSNSPVRYFDINSNKNDVRIYLDFEWLTILRSVKANIPKGNFTIDKNSIPKLSGPTKSDIDAIYKNLKEVIGDFDENHYEWPLWGQANGNFKNLQDQYNFINRIIE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU99</accession>
    <name>Q5CU99_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">BolA-like protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_3660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the BolA/IbaG family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89250.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626915.1">
        <property type="nucleotide sequence ID" value="XM_626915.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU99"/>
    <dbReference type="FunCoup" id="Q5CU99">
        <property type="interactions" value="75"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CU99"/>
    <dbReference type="GeneID" id="3373935"/>
    <dbReference type="KEGG" id="cpv:cgd3_3660"/>
    <dbReference type="InParanoid" id="Q5CU99"/>
    <dbReference type="OMA" id="VHAFSQK"/>
    <dbReference type="OrthoDB" id="4983at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051537">
        <property type="term" value="F:2 iron, 2 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006879">
        <property type="term" value="P:intracellular iron ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051604">
        <property type="term" value="P:protein maturation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.90">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045115">
        <property type="entry name" value="BOL2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002634">
        <property type="entry name" value="BolA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036065">
        <property type="entry name" value="BolA-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735:SF27">
        <property type="entry name" value="BOLA-LIKE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12735">
        <property type="entry name" value="BOLA-LIKE PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01722">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF003113">
        <property type="entry name" value="BolA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82657">
        <property type="entry name" value="BolA-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU003860"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89250.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="91" mass="10374" checksum="51E93403C6B1B01D" modified="2005-04-12" version="1" fragment="single">FKLSQMSIQETINERISKSLNPTLLDVVDVSNCNCGYMFKVIVVSDCFVGKRILERQRLVNEAIGEVYNEIHSVTMKCYTSEEYSKSQNSA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUF7</accession>
    <name>Q5CUF7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">TBC domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_3000</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89029.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626857.1">
        <property type="nucleotide sequence ID" value="XM_626857.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUF7"/>
    <dbReference type="STRING" id="353152.Q5CUF7"/>
    <dbReference type="GeneID" id="3374093"/>
    <dbReference type="KEGG" id="cpv:cgd3_3000"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3000"/>
    <dbReference type="InParanoid" id="Q5CUF7"/>
    <dbReference type="OMA" id="RRMEYHE"/>
    <dbReference type="OrthoDB" id="27140at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22957">
        <property type="entry name" value="TBC1 DOMAIN FAMILY MEMBER GTPASE-ACTIVATING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="121"/>
            <end position="344"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89029.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="543" mass="63437" checksum="6BF3D74B081A91EC" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUK8</accession>
    <name>Q5CUK8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Ribosomal protein S18A, rps18ap, HhH domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_2440</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the universal ribosomal protein uS13 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89075.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626806.1">
        <property type="nucleotide sequence ID" value="XM_626806.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUK8"/>
    <dbReference type="FunCoup" id="Q5CUK8">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUK8"/>
    <dbReference type="GeneID" id="3373915"/>
    <dbReference type="KEGG" id="cpv:cgd3_2440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2440"/>
    <dbReference type="InParanoid" id="Q5CUK8"/>
    <dbReference type="OMA" id="SYKGVRH"/>
    <dbReference type="OrthoDB" id="1702480at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.50:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="4.10.910.10:FF:000002">
        <property type="entry name" value="40S ribosomal protein S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.50">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.910.10">
        <property type="entry name" value="30s ribosomal protein s13, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_01315">
        <property type="entry name" value="Ribosomal_uS13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027437">
        <property type="entry name" value="Rbsml_uS13_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001892">
        <property type="entry name" value="Ribosomal_uS13"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010979">
        <property type="entry name" value="Ribosomal_uS13-like_H2TH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018269">
        <property type="entry name" value="Ribosomal_uS13_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003140">
        <property type="entry name" value="PRK04053.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S13/40S RIBOSOMAL PROTEIN S18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10871:SF3">
        <property type="entry name" value="SMALL RIBOSOMAL SUBUNIT PROTEIN US13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00416">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF002134">
        <property type="entry name" value="Ribosomal_S13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46946">
        <property type="entry name" value="S13-like H2TH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00646">
        <property type="entry name" value="RIBOSOMAL_S13_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50159">
        <property type="entry name" value="RIBOSOMAL_S13_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 6" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 6 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="134"/>
            <end position="153"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="137"/>
            <end position="153"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008080"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003830"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89075.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="153" mass="17542" checksum="A5938D824AF1D3BC" modified="2005-04-12" version="1">MSLQIMDQDFQHILRIMNTNVDGRQKIMYALTAIKGIGRRFSNIVCKKADVNLSKRAGQLSQEEINRIVAIVANPLQFNIPSYMLNRQKDVKDGKYKHITSNNLEASLREDLERLKKIRSHRGLRHHWGVRVRGQHTKTTGRGSRAAAAAKKR</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUT4</accession>
    <name>Q5CUT4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Apicomplexan specific region near N-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_1560</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89134.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626730.1">
        <property type="nucleotide sequence ID" value="XM_626730.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUT4"/>
    <dbReference type="FunCoup" id="Q5CUT4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="GeneID" id="3374024"/>
    <dbReference type="KEGG" id="cpv:cgd3_1560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1560"/>
    <dbReference type="InParanoid" id="Q5CUT4"/>
    <dbReference type="OMA" id="TRISWET"/>
    <dbReference type="OrthoDB" id="10007451at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016055">
        <property type="term" value="P:Wnt signaling pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.240.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001158">
        <property type="entry name" value="DIX"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038207">
        <property type="entry name" value="DIX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029071">
        <property type="entry name" value="Ubiquitin-like_domsf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42509">
        <property type="entry name" value="DIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42509:SF1">
        <property type="entry name" value="DIX DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00778">
        <property type="entry name" value="DIX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54236">
        <property type="entry name" value="Ubiquitin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0879">Wnt signaling pathway</keyword>
    <feature type="domain" description="DIX" evidence="3">
        <location>
            <begin position="8"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="119"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="127"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="2">
        <location>
            <begin position="140"/>
            <end position="159"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF00778"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89134.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="198" mass="22076" checksum="F5E0981CE5C60CB3" modified="2005-04-12" version="1">MISNEGLITVYYFIPSDGDKENNPNTFKVKGTHSTLTTKQIKDSFPLPGIYYFRFKVRVGNTYAWMDPLNDDDIVPLYDDAIIAKVLRINWDYKNKFTQRLNNKQDAYSISSGVIPSPNSLNQAFYQSQPPSQASQPHHPSSPPPPPPPPPPPPPPPPVLRHSVTASATIPSSSNSNNIDLIDLNCEHSKWNSNSGYI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUX4</accession>
    <name>Q5CUX4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SNAPc like transcription factor with 4 MYB/SANT domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd3_1120</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89285.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626690.1">
        <property type="nucleotide sequence ID" value="XM_626690.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUX4"/>
    <dbReference type="FunCoup" id="Q5CUX4">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUX4"/>
    <dbReference type="GeneID" id="3373839"/>
    <dbReference type="KEGG" id="cpv:cgd3_1120"/>
    <dbReference type="InParanoid" id="Q5CUX4"/>
    <dbReference type="OMA" id="PGRTNQQ"/>
    <dbReference type="OrthoDB" id="2143914at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019185">
        <property type="term" value="C:snRNA-activating protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000978">
        <property type="term" value="F:RNA polymerase II cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001006">
        <property type="term" value="F:RNA polymerase III type 3 promoter sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042795">
        <property type="term" value="P:snRNA transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042796">
        <property type="term" value="P:snRNA transcription by RNA polymerase III"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051575">
        <property type="entry name" value="Myb-like_DNA-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017930">
        <property type="entry name" value="Myb_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46621:SF1">
        <property type="entry name" value="SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13921">
        <property type="entry name" value="Myb_DNA-bind_6"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51294">
        <property type="entry name" value="HTH_MYB"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <keyword evidence="1" id="KW-0805">Transcription regulation</keyword>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="218"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="218"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="271"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="334"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="334"/>
            <end position="385"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="5">
        <location>
            <begin position="386"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="domain" description="HTH myb-type" evidence="6">
        <location>
            <begin position="390"/>
            <end position="441"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="7">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51294"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89285.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="567" mass="67292" checksum="B87BE2A516F5736F" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV71</accession>
    <name>Q5CV71_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">5 transmembrane domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_5200</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627398.1">
        <property type="nucleotide sequence ID" value="XM_627398.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV71"/>
    <dbReference type="GeneID" id="3374220"/>
    <dbReference type="KEGG" id="cpv:cgd8_5200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5200"/>
    <dbReference type="InParanoid" id="Q5CV71"/>
    <dbReference type="OMA" id="ENDWDTT"/>
    <dbReference type="OrthoDB" id="302705at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042392">
        <property type="term" value="F:sphingosine-1-phosphate phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03382">
        <property type="entry name" value="PAP2_dolichyldiphosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.144.10">
        <property type="entry name" value="Phosphatidic acid phosphatase type 2/haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039667">
        <property type="entry name" value="Dolichyldiphosphatase_PAP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000326">
        <property type="entry name" value="PAP2/HPO"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036938">
        <property type="entry name" value="PAP2/HPO_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969:SF13">
        <property type="entry name" value="AT30094P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14969">
        <property type="entry name" value="SPHINGOSINE-1-PHOSPHATE PHOSPHOHYDROLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01569">
        <property type="entry name" value="PAP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48317">
        <property type="entry name" value="Acid phosphatase/Vanadium-dependent haloperoxidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 6 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="177"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="201"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="213"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="243"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="277"/>
            <end position="300"/>
        </location>
    </feature>
    <feature type="domain" description="Phosphatidic acid phosphatase type 2/haloperoxidase" evidence="7">
        <location>
            <begin position="187"/>
            <end position="295"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01569"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="305" mass="33552" checksum="4BD3A8AE75AF3ECC" modified="2005-04-12" version="1">MLGSNASSSLQSLTDNPQFTGLRNIRQSKSIYPESILISSNNINSGSASNSCSNSIINGVNGSNNGNGLSSSVQTSRIKNDDLFVSPGSGKLLDKYWRSSTELWNDLECGIVYPDYSSNIGRNSLTSSQVSSGQYTHPFGLFSVSIHPVLTRKNALAIFYSFIPYIIGLVLFVWLLIGDSFVPAYALIMMLASSASSEFFLKNIFKSPRPPNSACASYGMPSSHCVTSYSILIWLLLENINALGFVSGFLFKLSIILITAPVPWARWYVEDHTIPQCIWGCIVGIFIGIFAFIMRIQFFYSNLVF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV72</accession>
    <name>Q5CV72_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Large protein with central conserved domain, possible BCRT domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_5190</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89641.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627397.1">
        <property type="nucleotide sequence ID" value="XM_627397.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CV72"/>
    <dbReference type="GeneID" id="3374219"/>
    <dbReference type="KEGG" id="cpv:cgd8_5190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5190"/>
    <dbReference type="InParanoid" id="Q5CV72"/>
    <dbReference type="OMA" id="SSHELNY"/>
    <dbReference type="OrthoDB" id="21095at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000724">
        <property type="term" value="P:double-strand break repair via homologous recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006355">
        <property type="term" value="P:regulation of DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015525">
        <property type="entry name" value="BRCA2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015187">
        <property type="entry name" value="BRCA2_OB_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002093">
        <property type="entry name" value="BRCA2_repeat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289:SF0">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11289">
        <property type="entry name" value="BREAST CANCER TYPE 2 SUSCEPTIBILITY PROTEIN BRCA2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09103">
        <property type="entry name" value="BRCA-2_OB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00634">
        <property type="entry name" value="BRCA2"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50138">
        <property type="entry name" value="BRCA2_REPEAT"/>
        <property type="match status" value="7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0227">DNA damage</keyword>
    <keyword evidence="3" id="KW-0234">DNA repair</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="domain" description="BRCA2 OB1" evidence="4">
        <location>
            <begin position="897"/>
            <end position="1017"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF09103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89641.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1442" mass="162026" checksum="68C5076AE2D8CD7B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV82</accession>
    <name>Q5CV82_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_5060</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89632.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627387.1">
        <property type="nucleotide sequence ID" value="XM_627387.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV82"/>
    <dbReference type="GeneID" id="3374209"/>
    <dbReference type="KEGG" id="cpv:cgd8_5060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5060"/>
    <dbReference type="InParanoid" id="Q5CV82"/>
    <dbReference type="OMA" id="PPITHQK"/>
    <dbReference type="OrthoDB" id="341387at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89632.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="152" mass="15612" checksum="CCB0039EB16F30EB" modified="2005-04-12" version="1">MSEQSNVQAVQPEQQTQQIAGAQAQIGMNAGVASAGVPYSSGMGQNMVFQSMAGGSGYFFPPNGSAPMSMGSGAFASVGMPGMYELDPNMLSGGYSAPYGSAMGSSFYLPNQYGGSGVMTMPYTYDPYGLINPGIIPPVATKIAKKKRSGCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVB8</accession>
    <name>Q5CVB8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4660</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89601.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627351.1">
        <property type="nucleotide sequence ID" value="XM_627351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVB8"/>
    <dbReference type="GeneID" id="3374450"/>
    <dbReference type="KEGG" id="cpv:cgd8_4660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4660"/>
    <dbReference type="InParanoid" id="Q5CVB8"/>
    <dbReference type="OMA" id="NNDAYPS"/>
    <dbReference type="OrthoDB" id="341189at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="141"/>
            <end position="160"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89601.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="397" mass="45395" checksum="52578A1582C0E690" modified="2005-04-12" version="1">MNSIQTKQLQYLLGVILLIGIVHALIFDQAKVEWIFSRQADAWLTNLRSYTTIYEYSQIDGTPDQSKLFSNYKTASNESMTLFEENVDHLFDYFFYGFGVEIVEFATQSNTTVDENDFKFKRINRKKIMDKLRQKTLPRNNIRSLKEENQDENNGSKTLPTSFYWPNETEKWAKISFLESGSITETNFTMSTYRNETGLLTNPKELALVFEVLEDNAFRWGGNYICQELVQEQLSTESNTPSYIPSEPQKANVLAKKGQTLWYGFMVTYPEGKMTSIGSFASPAPETNNEKLLMHIFSRHFAFSEPFIKQGKYPEIGQYDGSMSIISDTGIISTGNTFYYLKTATISSPSNPGLVVPPKFTGSVDKYPSKYDPYDFQDPLGPLFVPGKHCSEFLLNH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVD7</accession>
    <name>Q5CVD7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Protein with 12x transmembrane regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_4440</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89582.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627332.1">
        <property type="nucleotide sequence ID" value="XM_627332.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVD7"/>
    <dbReference type="GeneID" id="3374537"/>
    <dbReference type="KEGG" id="cpv:cgd8_4440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4440"/>
    <dbReference type="InParanoid" id="Q5CVD7"/>
    <dbReference type="OMA" id="YYNCKER"/>
    <dbReference type="OrthoDB" id="192300at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016747">
        <property type="term" value="F:acyltransferase activity, transferring groups other than amino-acyl groups"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002656">
        <property type="entry name" value="Acyl_transf_3_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050623">
        <property type="entry name" value="Glucan_succinyl_AcylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36927">
        <property type="entry name" value="BLR4337 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR36927:SF1">
        <property type="entry name" value="MDO-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01757">
        <property type="entry name" value="Acyl_transf_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="25"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="100"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="157"/>
            <end position="175"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="187"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="214"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="244"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="299"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="409"/>
            <end position="429"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="449"/>
            <end position="467"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="479"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="513"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="domain" description="Acyltransferase 3" evidence="3">
        <location>
            <begin position="24"/>
            <end position="329"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="554"/>
            <end position="576"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF01757"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89582.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="576" mass="65533" checksum="B4D1F72CE829AD75" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVE4</accession>
    <name>Q5CVE4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_4370</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="6">Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the NOP14 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89575.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627325.1">
        <property type="nucleotide sequence ID" value="XM_627325.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVE4"/>
    <dbReference type="GeneID" id="3374530"/>
    <dbReference type="KEGG" id="cpv:cgd8_4370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4370"/>
    <dbReference type="InParanoid" id="Q5CVE4"/>
    <dbReference type="OMA" id="KSCWPSL"/>
    <dbReference type="OrthoDB" id="441771at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030692">
        <property type="term" value="C:Noc4p-Nop14p complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030490">
        <property type="term" value="P:maturation of SSU-rRNA"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007276">
        <property type="entry name" value="Nop14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183">
        <property type="entry name" value="NOP14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23183:SF0">
        <property type="entry name" value="NUCLEOLAR PROTEIN 14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04147">
        <property type="entry name" value="Nop14"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="113"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="268"/>
            <end position="290"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="347"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="976"/>
            <end position="1000"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="217"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="7">
        <location>
            <begin position="317"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="131"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="275"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="347"/>
            <end position="412"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007466"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89575.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1000" mass="116200" checksum="25259FE95F878832" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVJ9</accession>
    <name>Q5CVJ9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_3780</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89534.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627270.1">
        <property type="nucleotide sequence ID" value="XM_627270.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVJ9"/>
    <dbReference type="GeneID" id="3374283"/>
    <dbReference type="KEGG" id="cpv:cgd8_3780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3780"/>
    <dbReference type="InParanoid" id="Q5CVJ9"/>
    <dbReference type="OrthoDB" id="428895at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="CDD" id="cd15841">
        <property type="entry name" value="SNARE_Qc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.110">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000727">
        <property type="entry name" value="T_SNARE_dom"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF58038">
        <property type="entry name" value="SNARE fusion complex"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50192">
        <property type="entry name" value="T_SNARE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="domain" description="T-SNARE coiled-coil homology" evidence="3">
        <location>
            <begin position="59"/>
            <end position="121"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="14"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="15"/>
            <end position="27"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89534.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="147" mass="17066" checksum="F305B31089BCC0F0" modified="2005-04-12" version="1">MERYAPIKEWEKESFSASGSNKNNVAKQTRIKENKRYSRVESDYDFESGLNNWTQDDNFTRPANTDSSINILENAVSQLKSVGYGIQSEINLHLDMLNEMNLNMDSTNRRIRISQKILNRLLEMASTMTLTIIAFLLFILLILQWVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVK3</accession>
    <name>Q5CVK3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Yer119cp like amino acid transporter, 11 transmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_3740</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Vacuole membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the amino acid/polyamine transporter 2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89531.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627266.1">
        <property type="nucleotide sequence ID" value="XM_627266.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVK3"/>
    <dbReference type="STRING" id="353152.Q5CVK3"/>
    <dbReference type="GeneID" id="3374280"/>
    <dbReference type="KEGG" id="cpv:cgd8_3740"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3740"/>
    <dbReference type="InParanoid" id="Q5CVK3"/>
    <dbReference type="OMA" id="FEFCGIV"/>
    <dbReference type="OrthoDB" id="438545at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061459">
        <property type="term" value="F:L-arginine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005313">
        <property type="term" value="F:L-glutamate transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005290">
        <property type="term" value="F:L-histidine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015189">
        <property type="term" value="F:L-lysine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015194">
        <property type="term" value="F:L-serine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005302">
        <property type="term" value="F:L-tyrosine transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013057">
        <property type="entry name" value="AA_transpt_TM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950">
        <property type="entry name" value="AMINO ACID TRANSPORTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22950:SF678">
        <property type="entry name" value="VACUOLAR AMINO ACID TRANSPORTER 5-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01490">
        <property type="entry name" value="Aa_trans"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0029">Amino-acid transport</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 9 11" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <keyword evidence="4" id="KW-0926">Vacuole</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="53"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="79"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="136"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="171"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="202"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="243"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="273"/>
            <end position="294"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="314"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="368"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="394"/>
            <end position="418"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="430"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="domain" description="Amino acid transporter transmembrane" evidence="10">
        <location>
            <begin position="47"/>
            <end position="441"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008066"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022554"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022970"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89531.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="457" mass="50827" checksum="F18088A7D4869217" modified="2005-04-12" version="1">MRTLNEEKSLLPSRSTIRKSSKESFISRLSEQVLIGMENFIEKRYKKGSMTSSFFALVNTTMGVGILGLPWAYSKNGLLQGIFMTIISGMFSTLACILLSEISLNEDPTGTMMPVTYYSIAEKTFPKLKSLIDTSILIMSLGSCITYLMVVVAVIQTLFGGFLAPYLSESNTRTAILLFVVIFIIGPASYPTSLAELTIINWIAVFSSLYVAAVVIFSFLVGLPELTTMLEKVELISTRRPIFMLQTFPIFVFSFTCHHNFLNVANELADKTLYKLVFSSVVSLGFCTLIYILMGSSGYMLFGNTLKSSDILSMFGTQSLTVVIAKIVLVSSLVFSFPVSCHSFRKSLAVIIKSGEDAEGSSTKDRHLLRTLTFIFLFICTTVTYFVSDLGLTYEFVGLFCSNTVCYFLPAVLHLKLFSDSPWNTSKIMAVILLIFSILVYPLCFSAIIYTHFFSDH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVL6</accession>
    <name>Q5CVL6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3600</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89715.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627253.1">
        <property type="nucleotide sequence ID" value="XM_627253.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVL6"/>
    <dbReference type="GeneID" id="3374622"/>
    <dbReference type="KEGG" id="cpv:cgd8_3600"/>
    <dbReference type="InParanoid" id="Q5CVL6"/>
    <dbReference type="OMA" id="IAKMLVW"/>
    <dbReference type="OrthoDB" id="342450at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="363"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="464"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="317"/>
            <end position="330"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="367"/>
            <end position="380"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="381"/>
            <end position="400"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="464"/>
            <end position="478"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="479"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89715.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="501" mass="57657" checksum="684FE876861AB0D3" modified="2005-04-12" version="1" fragment="single">INFILEYNSKKKKFTKFDNKVIGNIQREVEISVENKGNFYNHPEIIKEYNIKNNTFVKLWLSDIELKYSGLFAFGGDIATVKGQKGLEDQEQEEFEINKIIEENRLLDKLNLLRQHDIEATDSGDISPFDEVTRKKILASGIKIVYQKSDSQPSSATLKKVIDNVNAPDDLEDEDDTVILITPNQQIAALEILAGRKLINAIQLNIEIDETVTESKNLIESSVGLEYEEKNFPECVEIKKNLIQKIGKLKLENANLSMRAQKLRNKERKTKEYRNILENIERNKESLHNQNIELLKIEKRIQQLSVEDRMEDKIENKIEDSNQLEAKPEELQDSEASLKKKERRKVIIAAILEEAKRRKLAEKNKETAQFSQNNINSEGSNVDKKGVESNEGIKPKEELQDSEIKEIRQIAKMLVWLQENNPKTSASAETRGERGASAIKNLRKLYISDEEHFKKVAEKIKNNFEEKVLENKQKESSKRNTPTMDSNSNSKGETSQNTKQD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVL8</accession>
    <name>Q5CVL8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89520.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627251.1">
        <property type="nucleotide sequence ID" value="XM_627251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVL8"/>
    <dbReference type="GeneID" id="3374295"/>
    <dbReference type="KEGG" id="cpv:cgd8_3580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3580"/>
    <dbReference type="InParanoid" id="Q5CVL8"/>
    <dbReference type="OrthoDB" id="343050at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="215"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="220"/>
            <end position="235"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89520.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="381" mass="44060" checksum="FC3DC362A7ECB4CE" modified="2005-04-12" version="1">MKISGKTIVCREQFAKLAFITVRMKSNLILVPILTFLIFFNFVDSSSIDHAQVKHVESIRDSIFEDILAQMNLTNEKILKDEQMNLYYIYFNETSAYEHEKCDYQINTLKFVNKTHTCYILGDKNNKLFDELSFIINQDRNSTDEIYLKDLYNIKNISKITDKLELENTNSRVNFGIQSQPNFRSLASFHELNHNEINYRRNKLKRRYLDDDMDDSKLSKKEKKKRKKRKKMLKKREKELREKRKKYRSPLDKLRSTMKWMACIEISLAVCSCCFALVQAVVLPFISPIPFGSRIQPMNGQQIRGFEDYGFYGGFQQSNGVYNGFPLNNGNINGSHLSCNGNCNCNNGIKGTLGNTLGISGSIIGNNLFSRMGQLQRNGNA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVL9</accession>
    <name>Q5CVL9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted secreted protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_3570</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89519.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627250.1">
        <property type="nucleotide sequence ID" value="XM_627250.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVL9"/>
    <dbReference type="GeneID" id="3374294"/>
    <dbReference type="KEGG" id="cpv:cgd8_3570"/>
    <dbReference type="InParanoid" id="Q5CVL9"/>
    <dbReference type="OMA" id="RYCRENI"/>
    <dbReference type="OrthoDB" id="341743at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="436"/>
            <end position="477"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="452"/>
            <end position="470"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89519.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="477" mass="55368" checksum="5F299DD2F10E9103" modified="2005-04-12" version="1">MLFALEECLLPSKFFIQVAFCTFDAIYPFLEGVPSGEVMQDIVGAAMYSVNKIGDDFSFDTKYCRKAIAMIPDSRINLEVDSKCNDISLCMHQDHFPQLSRSLSVFNLEQLIEKSFILHGLEYQLRVRKLIQSILWKIIKSAHKSNIKREHMNPNRLFSIIRAYVLTLYIRHSSLIIPGWYLNKFPSAKNSLSFVYVKNEDYTEQSAYINYCARKLKWWLDAFQPIVSPIFPNMDTKDEVSRSACFQAGRAGFVSNEEFDFSNMIEEGTESVDLLNLQLPIILKKSEEEIKYIRNNNLRKAQENRKWTSHYESYPYSLNGRMFQDIIHEKDKLNLQNLAQEAELSQDKDTLLDEVKDLLGRKKNGDEPSIKYENIFDTNGRESDKKTSFSPVEFIAQLKQDNIDLESHDANTSNISYKPRSIIRDQLIQPQSTHSLKQGIYGNAMDDTNSGFEEDEIEEFEDEDEFESENDNNYSTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVM9</accession>
    <name>Q5CVM9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Membrane associated protein with a RING finger, 4xtransmembrane domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_3470</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89511.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627240.1">
        <property type="nucleotide sequence ID" value="XM_627240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVM9"/>
    <dbReference type="STRING" id="353152.Q5CVM9"/>
    <dbReference type="GeneID" id="3374304"/>
    <dbReference type="KEGG" id="cpv:cgd8_3470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3470"/>
    <dbReference type="InParanoid" id="Q5CVM9"/>
    <dbReference type="OMA" id="KYHASAD"/>
    <dbReference type="OrthoDB" id="9984778at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051834">
        <property type="entry name" value="RING_finger_E3_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931:SF3">
        <property type="entry name" value="RING ZINC FINGER-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45931">
        <property type="entry name" value="SI:CH211-59O9.10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13639">
        <property type="entry name" value="zf-RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0472">Membrane</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="139"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="181"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="234"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="314"/>
            <end position="340"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="392"/>
            <end position="433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89511.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="437" mass="50744" checksum="B8BFAEC7A3C5D6B0" modified="2005-04-12" version="1">MDNNLGIYKRYVSYYIHKKQHVALRSLTQNTGKANFSNKTIRKIMLVKERINIWCRKYLNIQPLFRTQDNVIISSPVTESSLRSIYGRTTPNITPSNHSDYVSGINQLSNNPLINNMSQQEHASDDSLMQLVCNYPEKAIWFLSCNLLIGMISFISLGLISTGLTLKNWRSDFSNSPFLCIWLLIHGSLQMLQGIFRFYYKIILERERINSNSTRVIQILQAVRRLTANRAWKIGKVLSFIYYTWFMFGFYWILSVRPNVETFSGQSRKFVGSLSDSQLADYSLIAGHRSYLLLGNGSLYSLKDLIKVDCRSGIWPLYLIIMLICTFRIIFMVSFFYFVFPTVVSSEYSDNKLRACTINKLESLPVKTYSEWKKLKENELLLNKHSFLQDNCIICLNDFSSFEMARCLPCNHVFHDDCIDMWLLRNAVCPLCQASLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVP1</accession>
    <name>Q5CVP1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 4C</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd8_3330</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="12" key="2">
        <citation type="submission" date="2007-01" db="PDB data bank">
            <title>Crystal structure of putative Cryptosporidium parvum translation initiation factor eIF-1A.</title>
            <authorList>
                <person name="Dong A."/>
                <person name="Lew J."/>
                <person name="Zhao Y."/>
                <person name="Hassanali A."/>
                <person name="Lin L."/>
                <person name="Qiu W."/>
                <person name="Brokx S.J."/>
                <person name="Wasney G."/>
                <person name="Vedadi M."/>
                <person name="Kozieradzki I."/>
                <person name="Bochkarev A."/>
                <person name="Edwards A.M."/>
                <person name="Arrowsmith C.H."/>
                <person name="Weigelt J."/>
                <person name="Sundstrom M."/>
                <person name="Hui R."/>
                <person name="Altamentova S."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 1-117</scope>
    </reference>
    <comment type="function">
        <text evidence="7">Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 6">Belongs to the eIF-1A family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89502.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627228.1">
        <property type="nucleotide sequence ID" value="XM_627228.1"/>
    </dbReference>
    <dbReference type="PDB" id="2OQK">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="1.80 A"/>
        <property type="chains" value="A=1-117"/>
    </dbReference>
    <dbReference type="PDBsum" id="2OQK"/>
    <dbReference type="AlphaFoldDB" id="Q5CVP1"/>
    <dbReference type="SMR" id="Q5CVP1"/>
    <dbReference type="FunCoup" id="Q5CVP1">
        <property type="interactions" value="327"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVP1"/>
    <dbReference type="GeneID" id="3374252"/>
    <dbReference type="KEGG" id="cpv:cgd8_3330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3330"/>
    <dbReference type="InParanoid" id="Q5CVP1"/>
    <dbReference type="OMA" id="RRVMMHA"/>
    <dbReference type="OrthoDB" id="274995at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CVP1"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd05793">
        <property type="entry name" value="S1_IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00216">
        <property type="entry name" value="aIF_1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006196">
        <property type="entry name" value="RNA-binding_domain_S1_IF1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001253">
        <property type="entry name" value="TIF_eIF-1A"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018104">
        <property type="entry name" value="TIF_eIF-1A_CS"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00523">
        <property type="entry name" value="eIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21668">
        <property type="entry name" value="EIF-1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01176">
        <property type="entry name" value="eIF-1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00652">
        <property type="entry name" value="eIF1a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01262">
        <property type="entry name" value="IF1A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50832">
        <property type="entry name" value="S1_IF1_TYPE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="12" id="KW-0002">3D-structure</keyword>
    <keyword evidence="2 5 7" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 5 7" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="S1-like" evidence="9">
        <location>
            <begin position="22"/>
            <end position="96"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="8">
        <location>
            <begin position="1"/>
            <end position="15"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="16"/>
            <end position="26"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007392"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00032507"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00181"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU004364"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU004365"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50832"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89502.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="12">
        <source>
            <dbReference type="PDB" id="2OQK"/>
        </source>
    </evidence>
    <sequence length="143" mass="16328" checksum="1310DB90E8BB6722" modified="2005-04-12" version="1">MPKNKGKGGKNRRRGKNDSEGDKRELVFKEEGQEYGQVQRMLGNGRLDAYCFDGQKRLCHIRGKMRKKVWVNPGDIVLVSLRDFQDSKGDIILKYTPDEARALKSKGEIPETTKINESDIFEDGYDEVGIEFDETEGVDIEDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVY9</accession>
    <name>Q5CVY9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_2270</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89423.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627130.1">
        <property type="nucleotide sequence ID" value="XM_627130.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVY9"/>
    <dbReference type="GeneID" id="3374487"/>
    <dbReference type="KEGG" id="cpv:cgd8_2270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2270"/>
    <dbReference type="InParanoid" id="Q5CVY9"/>
    <dbReference type="OMA" id="HWANEYS"/>
    <dbReference type="OrthoDB" id="343363at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="95"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="719"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="825"/>
            <end position="846"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1015"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="360"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="465"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="95"/>
            <end position="118"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="132"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="207"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="719"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="742"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="764"/>
            <end position="775"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="1036"/>
            <end position="1047"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89423.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1063" mass="123729" checksum="911E411954E7F148" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW13</accession>
    <name>Q5CW13_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="2">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_2020</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>2'-deoxyribonucleotide-(2'-deoxyribose 5'-phosphate)-2'-deoxyribonucleotide-DNA = a 3'-end 2'-deoxyribonucleotide-(2,3-dehydro-2,3-deoxyribose 5'-phosphate)-DNA + a 5'-end 5'-phospho-2'-deoxyribonucleoside-DNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:66592"/>
            <dbReference type="Rhea" id="RHEA-COMP:13180"/>
            <dbReference type="Rhea" id="RHEA-COMP:16897"/>
            <dbReference type="Rhea" id="RHEA-COMP:17067"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:136412"/>
            <dbReference type="ChEBI" id="CHEBI:157695"/>
            <dbReference type="ChEBI" id="CHEBI:167181"/>
            <dbReference type="EC" id="4.2.99.18"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the type-1 OGG1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89690.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627106.1">
        <property type="nucleotide sequence ID" value="XM_627106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW13"/>
    <dbReference type="FunCoup" id="Q5CW13">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW13"/>
    <dbReference type="GeneID" id="3374412"/>
    <dbReference type="KEGG" id="cpv:cgd8_2020"/>
    <dbReference type="InParanoid" id="Q5CW13"/>
    <dbReference type="OMA" id="ITKMCHS"/>
    <dbReference type="OrthoDB" id="238681at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034039">
        <property type="term" value="F:8-oxo-7,8-dihydroguanine DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003684">
        <property type="term" value="F:damaged DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.40">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012904">
        <property type="entry name" value="OGG_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052054">
        <property type="entry name" value="Oxidative_DNA_repair_enzyme"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242">
        <property type="entry name" value="8-OXOGUANINE DNA GLYCOSYLASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10242:SF2">
        <property type="entry name" value="N-GLYCOSYLASE_DNA LYASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07934">
        <property type="entry name" value="OGG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="8" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0511">Multifunctional enzyme</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="10">
        <location>
            <begin position="196"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023268"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00044632"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89690.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="390" mass="44852" checksum="0AF413A32B5294F1" modified="2005-04-12" version="1" fragment="single">ILMNQIKFESLNVPREELRISKCLPAGQSFSWRKVSKDSFVGILGHRVFQLKELENDTLYRCLYDGCSKVIKDEELDDYDDQEIENIPLKKNKVIKDEKNILIPNIDDDLCKRETSIKLSIFYCCNSTPNEHIRHYLNLDFNWENESKMAELEQPIHSLSEAYMNWNEADPCISSSPKGIRLLNIDPIEALFVGVITANNNISRITSIVKNMRKNLGTFLCNISDSEIVSCNETDESELDIDYHYFSFPTSLQIFNNASEEMLREKCGVGYRAKSIISISKELNQKFESDRVFVDYIKSLDYSNATLYLQKFHGIGQKVADFVLLSGFGFSAAVPVDTHILKYICKHVKFLNNTSLSKNKYVMGAQFFRDKFRLLPGWAQLVLFSSSVLK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW46</accession>
    <name>Q5CW46_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
            <shortName evidence="5">V-ATPase subunit B</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">Vacuolar proton pump subunit B</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_1670</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the ATPase alpha/beta chains family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89683.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627073.1">
        <property type="nucleotide sequence ID" value="XM_627073.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW46"/>
    <dbReference type="FunCoup" id="Q5CW46">
        <property type="interactions" value="71"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW46"/>
    <dbReference type="GeneID" id="3374405"/>
    <dbReference type="KEGG" id="cpv:cgd8_1670"/>
    <dbReference type="InParanoid" id="Q5CW46"/>
    <dbReference type="OMA" id="EGFKIKP"/>
    <dbReference type="OrthoDB" id="1735853at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033180">
        <property type="term" value="C:proton-transporting V-type ATPase, V1 domain"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046034">
        <property type="term" value="P:ATP metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007035">
        <property type="term" value="P:vacuolar acidification"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18112">
        <property type="entry name" value="ATP-synt_V_A-type_beta_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18118">
        <property type="entry name" value="ATP-synt_V_A-type_beta_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01135">
        <property type="entry name" value="V_A-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.12240:FF:000001">
        <property type="entry name" value="V-type proton ATPase subunit B, brain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.12240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00310">
        <property type="entry name" value="ATP_synth_B_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR055190">
        <property type="entry name" value="ATP-synt_VA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020003">
        <property type="entry name" value="ATPase_a/bsu_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004100">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000194">
        <property type="entry name" value="ATPase_F1/V1/A1_a/bsu_nucl-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005723">
        <property type="entry name" value="ATPase_V1-cplx_bsu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022879">
        <property type="entry name" value="V-ATPase_su_B/beta"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003235">
        <property type="entry name" value="PRK04196.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01040">
        <property type="entry name" value="V-ATPase_V1_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43389:SF4">
        <property type="entry name" value="V-TYPE PROTON ATPASE SUBUNIT B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00006">
        <property type="entry name" value="ATP-synt_ab"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02874">
        <property type="entry name" value="ATP-synt_ab_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF22919">
        <property type="entry name" value="ATP-synt_VA_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039114">
        <property type="entry name" value="V-ATPsynth_beta/V-ATPase_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00152">
        <property type="entry name" value="ATPASE_ALPHA_BETA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0375">Hydrogen ion transport</keyword>
    <keyword evidence="4 5" id="KW-0406">Ion transport</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0813">Transport</keyword>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit N-terminal" evidence="7">
        <location>
            <begin position="45"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="domain" description="ATPase F1/V1/A1 complex alpha/beta subunit nucleotide-binding" evidence="6">
        <location>
            <begin position="168"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="domain" description="ATP synthase A/B type C-terminal" evidence="8">
        <location>
            <begin position="399"/>
            <end position="498"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU366021"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF00006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF02874"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="Pfam" id="PF22919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89683.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="508" mass="57023" checksum="299E23331AFA725F" modified="2005-04-12" version="1" fragment="single">RSYNSLFQSDSNYRKMVTSGQAYEANVAAVTRNYNIAPRMEYRTVSGVQGPLVILDNVKFPKYNEIVRITLGDGSIREGQVLEVKGSRAVVQVFEGTTGIDNQSCRVEFTGDVLCMPITEDMLGRTFNGSGKPIDNGPPIFAEDYIDINGSPINPYCRVHPREMIQTGISAIDVMNSVVRGQKIPLFSAAGLPHNDIGAQICRQASLVSGKDVMDHSDDNFAVVFAAMGVNMETARFFRRDFEENGSMERVCLFLNLANDPTIERILTPKLALTTAEYLAYEKDLHVFVVMTDMSSYADALREVSAAREEVPGRRGYPGYMYTDLSTIYERAGRIEGRNGSITQFPILTMPNDDITHPIPDLTGYITEGQIFVDRALYNRQIYPPINVLPSLSRLMKSGIGTGLTREDHPSVSDQLYANYAIGQDTRAMVAVVGEEALSADDLLYLEFTSKFESKFLSQGPYEKRDIFESLDLAWELLRTFPEDMLKKIKHDLLQKYYPRDNYIQHSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWB4</accession>
    <name>Q5CWB4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">VPS13 like protein involved in vacuolar protein trafficking</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_970</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89322.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627005.1">
        <property type="nucleotide sequence ID" value="XM_627005.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWB4"/>
    <dbReference type="GeneID" id="3374431"/>
    <dbReference type="KEGG" id="cpv:cgd8_970"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_970"/>
    <dbReference type="InParanoid" id="Q5CWB4"/>
    <dbReference type="OMA" id="TIAQWHI"/>
    <dbReference type="OrthoDB" id="428159at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="232"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="355"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="943"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1074"/>
            <end position="1104"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1209"/>
            <end position="1228"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1269"/>
            <end position="1310"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1371"/>
            <end position="1393"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1748"/>
            <end position="1776"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1806"/>
            <end position="1828"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2005"/>
            <end position="2024"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2078"/>
            <end position="2105"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="357"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="949"/>
            <end position="970"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1103"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1214"/>
            <end position="1224"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1288"/>
            <end position="1309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1806"/>
            <end position="1825"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="2084"/>
            <end position="2093"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89322.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2105" mass="238331" checksum="AF53A300B37C0404" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWG6</accession>
    <name>Q5CWG6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">CKK domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_5160</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90089.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627838.1">
        <property type="nucleotide sequence ID" value="XM_627838.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWG6"/>
    <dbReference type="GeneID" id="3375834"/>
    <dbReference type="KEGG" id="cpv:cgd6_5160"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5160"/>
    <dbReference type="InParanoid" id="Q5CWG6"/>
    <dbReference type="OrthoDB" id="2125658at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005516">
        <property type="term" value="F:calmodulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.360">
        <property type="entry name" value="CKK domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032940">
        <property type="entry name" value="CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014797">
        <property type="entry name" value="CKK_CAMSAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038209">
        <property type="entry name" value="CKK_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011033">
        <property type="entry name" value="PRC_barrel-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595">
        <property type="entry name" value="PATRONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21595:SF0">
        <property type="entry name" value="PATRONIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08683">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01051">
        <property type="entry name" value="CAMSAP_CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50346">
        <property type="entry name" value="PRC-barrel domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51508">
        <property type="entry name" value="CKK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CKK" evidence="1">
        <location>
            <begin position="208"/>
            <end position="343"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51508"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90089.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="343" mass="40937" checksum="AD24C795B738A83A" modified="2007-04-03" version="1">MASMSRHYNNISELPYIDLDRIEELRRQNDRCCCNSRGEKLYQRNCMDYQYSKREGCIRERRGYCDFELDELREDDGCIHGIRFYKDSNLDQNYDLGFEKNCNRLPILHSNCKLRTMNDSNYYSNNGNNCIYCNASLERTSNTRERDFFNGQDRRVHSYSKQCLSEDSDTNDYKDIGQEYNSDYEYRRGQNVSRNNCERQFSDEYSDLSEDMEVVIKRNNRNVISLALNWISLSGEHNKKIRKFVMDSMNSIELKDLNHFIILFQYDDHKGIRGLYSFFQKENNWQCVVEIVPNCPKVIRKEMVHTLYKFDTSQKLFKPINRSKKITDIVDGLSIKNEYLSTQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWL6</accession>
    <name>Q5CWL6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Lengsin</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="7">Glutamate--ammonia ligase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="11">Glutamate-ammonia ligase domain-containing protein 1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd6_4570</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May act as a component of the cytoskeleton or as a chaperone for the reorganization of intermediate filament proteins during terminal differentiation in the lens. Does not seem to have enzymatic activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Dodecamer. Interacts with BFSP2 and VIM.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 12 13">Belongs to the glutamine synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90048.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627788.1">
        <property type="nucleotide sequence ID" value="XM_627788.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWL6"/>
    <dbReference type="FunCoup" id="Q5CWL6">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWL6"/>
    <dbReference type="GeneID" id="3375793"/>
    <dbReference type="KEGG" id="cpv:cgd6_4570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4570"/>
    <dbReference type="InParanoid" id="Q5CWL6"/>
    <dbReference type="OMA" id="PHPHEFE"/>
    <dbReference type="OrthoDB" id="77835at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004356">
        <property type="term" value="F:glutamine synthetase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006542">
        <property type="term" value="P:glutamine biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019740">
        <property type="term" value="P:nitrogen utilization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.70">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.590.10">
        <property type="entry name" value="Glutamine synthetase/guanido kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008147">
        <property type="entry name" value="Gln_synt_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036651">
        <property type="entry name" value="Gln_synt_N_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014746">
        <property type="entry name" value="Gln_synth/guanido_kin_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008146">
        <property type="entry name" value="Gln_synth_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027303">
        <property type="entry name" value="Gln_synth_gly_rich_site"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004809">
        <property type="entry name" value="Gln_synth_I"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00653">
        <property type="entry name" value="GlnA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43407">
        <property type="entry name" value="GLUTAMINE SYNTHETASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43407:SF1">
        <property type="entry name" value="LENGSIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00120">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03951">
        <property type="entry name" value="Gln-synt_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01230">
        <property type="entry name" value="Gln-synt_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54368">
        <property type="entry name" value="Glutamine synthetase, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55931">
        <property type="entry name" value="Glutamine synthetase/guanido kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00181">
        <property type="entry name" value="GLNA_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51986">
        <property type="entry name" value="GS_BETA_GRASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51987">
        <property type="entry name" value="GS_CATALYTIC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4" id="KW-0436">Ligase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GS beta-grasp" evidence="14">
        <location>
            <begin position="24"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="domain" description="GS catalytic" evidence="15">
        <location>
            <begin position="116"/>
            <end position="481"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009897"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00030668"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00037583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00038790"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00039404"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00042675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01330"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="RuleBase" id="RU000384"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51986"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51987"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK90048.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="481" mass="54314" checksum="D7BEAB422FA18886" modified="2007-04-03" version="1">MNNFKVSSFVCRSFDELYSAIQTENIEYLNYSFCDTFGSLHHITISSNSFKSGKDIQKGIAFDSSSVRGMQFGDFSDMIVVPDFEKVWIDPFFDRKTLHVACFVLFHTGEPSPGCVRSISKRAQEALSLSGIADKCFIGPEIEFFVFESVSYNNSPNHSYFCLDGDEAYWNSGNNATFYPHNRPNLASRRPLKQAYCAPYPVDRDLSLRSEILEELENIGVTVEKHHHEVATCQHEIGVHCSTLVQSADIVESIRYLIKGIAHRNNKTATFMPKPLGNDNGSGMHINISLWKNEKNIFFDPESSYYNLSNQALYFIGGILSHAKAIMAFTNPTTNSYKRLATGYETPTKLSYGAGDRSSSIRIPLSGFSCTKTQRIEFRIPDSSACPHLAFSAILCAGIDGILHKIHPAAYLNTIKSQSNEYNLPKSLTEALQNLEEDYEFLIKDGVFSHEFILNYIKLKRDEVVLVESFPTPKEFELYYD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX02</accession>
    <name>Q5CX02_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_3060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89936.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627652.1">
        <property type="nucleotide sequence ID" value="XM_627652.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX02"/>
    <dbReference type="GeneID" id="3375681"/>
    <dbReference type="KEGG" id="cpv:cgd6_3060"/>
    <dbReference type="InParanoid" id="Q5CX02"/>
    <dbReference type="OrthoDB" id="344289at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="88"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="30"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="39"/>
            <end position="51"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="59"/>
            <end position="68"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89936.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="140" mass="16335" checksum="1C57C7C6E3EDF87A" modified="2007-04-03" version="1">MASSLLENDIISQNIGNGLISKKKSKKKLNKFSKSSNSELEKQQNDKKEYYPTKNAMMESEDDDLTDEEFEEYEEYEEDMSNFDYLKIFKIPLILFILSFISVLFVDLFGKDYLGNELENGIYNMIDPNYGSFIWNLSGK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX06</accession>
    <name>Q5CX06_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_3020</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89932.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627648.1">
        <property type="nucleotide sequence ID" value="XM_627648.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX06"/>
    <dbReference type="GeneID" id="3375677"/>
    <dbReference type="KEGG" id="cpv:cgd6_3020"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3020"/>
    <dbReference type="InParanoid" id="Q5CX06"/>
    <dbReference type="OMA" id="YINDEAH"/>
    <dbReference type="OrthoDB" id="342603at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="56"/>
            <end position="74"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="80"/>
            <end position="97"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="109"/>
            <end position="130"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="142"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="191"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="250"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="278"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89932.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="427" mass="48924" checksum="EEB4AFD0CE8D8065" modified="2005-04-12" version="1">MTQGVILEMIPRVEQTENVIEEKPVENNDTDLAKLSNKIFGNEMANVPLVFDEFPVTKLLLSFFVILFICFGVIDMILGFIRLGLMSFIISMFVLFFRCGERNRQHSSIFVLFIVALTSSLSWNSISNYILKNEGTLFEEKIYPLLILEFSSSLFLTLWLMLIALSGYSVKNQQNIYIDNQLYRTNTNLRFTALSAFNWYLISMGFEFSVLVLYLLEGFYIVSIIPFISLLVSMFYVISKSKRILQYSEIFLPFVMLAYVILRMIYEWVAPDDYSSMIGAYLVTIMVFKQVVGLSILFIPSINYYDMINDNGSYSVTVVVSFKIHQNKQENAVKSADIIDISPTNRVIAENPESENREEEAITVIQVSSSEDPEGLIKSVQNDQIELNKESFDLETQKSHSAVEDDAEANIPYEDESLKIEINSKLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX23</accession>
    <name>Q5CX23_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Splicing factor 3a 66kD N-terminus C2H2 domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_2830</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SF3A2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89916.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627631.1">
        <property type="nucleotide sequence ID" value="XM_627631.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX23"/>
    <dbReference type="FunCoup" id="Q5CX23">
        <property type="interactions" value="227"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX23"/>
    <dbReference type="GeneID" id="3376156"/>
    <dbReference type="KEGG" id="cpv:cgd6_2830"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2830"/>
    <dbReference type="InParanoid" id="Q5CX23"/>
    <dbReference type="OMA" id="EFWIQIM"/>
    <dbReference type="OrthoDB" id="10250970at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005686">
        <property type="term" value="C:U2 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071004">
        <property type="term" value="C:U2-type prespliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000245">
        <property type="term" value="P:spliceosomal complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.2690">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000690">
        <property type="entry name" value="Matrin/U1-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003604">
        <property type="entry name" value="Matrin/U1-like-C_Znf_C2H2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052092">
        <property type="entry name" value="SF3A2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031781">
        <property type="entry name" value="SF3A2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036236">
        <property type="entry name" value="Znf_C2H2_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23205:SF0">
        <property type="entry name" value="SPLICING FACTOR 3A SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16835">
        <property type="entry name" value="SF3A2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12874">
        <property type="entry name" value="zf-met"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00451">
        <property type="entry name" value="ZnF_U1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57667">
        <property type="entry name" value="beta-beta-alpha zinc fingers"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50171">
        <property type="entry name" value="ZF_MATRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="Matrin-type" evidence="11">
        <location>
            <begin position="54"/>
            <end position="84"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="10">
        <location>
            <begin position="98"/>
            <end position="122"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89916.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="216" mass="25167" checksum="EC42329AF8554612" modified="2007-04-03" version="1">MDYENRGGHKTGSGALASSQDIAIERRERLRRLALESIDLSKDPYYMKNHLGQVECRLCSTIHTNEGSYLSHTQGRKHQTNLAYRASKEKNLKAVVKPQAENPEQAKPRAPRIGQPKYKVSKHREGSTGTNCVYCKFYFQEILEDHIPGYRIMSCWEQKVEKPNPKYQYLFVGAEPYNTIGIRIPNIELIKQRTQTYWDEQRKIYHIQLYLSSSKQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX45</accession>
    <name>Q5CX45_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_2560</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89898.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627609.1">
        <property type="nucleotide sequence ID" value="XM_627609.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX45"/>
    <dbReference type="STRING" id="353152.Q5CX45"/>
    <dbReference type="GeneID" id="3376138"/>
    <dbReference type="KEGG" id="cpv:cgd6_2560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2560"/>
    <dbReference type="InParanoid" id="Q5CX45"/>
    <dbReference type="OMA" id="RSIFCIG"/>
    <dbReference type="OrthoDB" id="343647at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="214"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="413"/>
            <end position="442"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="718"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1012"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1065"/>
            <end position="1134"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="216"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="234"/>
            <end position="250"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="739"/>
            <end position="754"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1076"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="1122"/>
            <end position="1134"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89898.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1134" mass="123330" checksum="4713519A4FC15513" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX59</accession>
    <name>Q5CX59_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">mRNA guanylyltransferase</fullName>
            <ecNumber evidence="2">2.7.7.50</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd6_2380</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>a 5'-end diphospho-ribonucleoside in mRNA + GTP + H(+) = a 5'-end (5'-triphosphoguanosine)-ribonucleoside in mRNA + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:67012"/>
            <dbReference type="Rhea" id="RHEA-COMP:17165"/>
            <dbReference type="Rhea" id="RHEA-COMP:17166"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:37565"/>
            <dbReference type="ChEBI" id="CHEBI:167616"/>
            <dbReference type="ChEBI" id="CHEBI:167617"/>
            <dbReference type="EC" id="2.7.7.50"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="10">
            <dbReference type="Rhea" id="RHEA:67013"/>
        </physiologicalReaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.50" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90137.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627595.1">
        <property type="nucleotide sequence ID" value="XM_627595.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX59"/>
    <dbReference type="FunCoup" id="Q5CX59">
        <property type="interactions" value="322"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX59"/>
    <dbReference type="GeneID" id="3375882"/>
    <dbReference type="KEGG" id="cpv:cgd6_2380"/>
    <dbReference type="InParanoid" id="Q5CX59"/>
    <dbReference type="OMA" id="KDYYVCE"/>
    <dbReference type="OrthoDB" id="200924at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004484">
        <property type="term" value="F:mRNA guanylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006370">
        <property type="term" value="P:7-methylguanosine mRNA capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd07895">
        <property type="entry name" value="Adenylation_mRNA_capping"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.470.30">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001339">
        <property type="entry name" value="mRNA_cap_enzyme_adenylation"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013846">
        <property type="entry name" value="mRNA_cap_enzyme_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051029">
        <property type="entry name" value="mRNA_Capping_Enz/RNA_Phosphat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10367:SF17">
        <property type="entry name" value="MRNA-CAPPING ENZYME"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03919">
        <property type="entry name" value="mRNA_cap_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01331">
        <property type="entry name" value="mRNA_cap_enzyme"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56091">
        <property type="entry name" value="DNA ligase/mRNA capping enzyme, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="8" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="7" id="KW-0506">mRNA capping</keyword>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="5 13" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="11">
        <location>
            <begin position="36"/>
            <end position="92"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme adenylation" evidence="11">
        <location>
            <begin position="131"/>
            <end position="267"/>
        </location>
    </feature>
    <feature type="domain" description="mRNA capping enzyme C-terminal" evidence="12">
        <location>
            <begin position="325"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="13">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023042"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00044624"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01331"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF03919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK90137.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="442" mass="51028" checksum="7C8DBA6A9D426402" modified="2005-04-12" version="1" fragment="single">ILNIFLIANIDSKRNEILKKVRSFCGWRQDTFPGSQPVSLNRQKLESCIGKNLYVACEKTDGIRLLLYAASRRVFLIDRNQKINMVKMTLPSSFWDTVYEVKSSNKNIENLETQKIFSGRNSELLNLDPTRDEHAQYFQQNTLLDGELVKDTIEVDGQKRYILRYLIYDCICIERDDTVKSLPLLERLKLAYLKVVIPKCKYDQNRSTISIDPTPFELYLKDFFEVDEVPAILNFSRRLPHPSDGIIFTPVHLPYVPGTCPQLLKWKPPHLNTADFAAIFYAESESYDSRVFLELLVGIRGVRASVNCFCVPKGSVYNQLVDQFKLYRTSGQILECYYDENAIYSKPTKSEDGNILWNKPFTTVQGGWIVERIRSDKNSPNDINTVNRVFESIRDGINSEVLINTIKLYQKSGKKSVVEYCNVPEFVTNCRKGQIEDKRSEI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXB0</accession>
    <name>Q5CXB0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">ATP-dependent RNA helicase</fullName>
            <ecNumber evidence="7">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_1780</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">RNA helicase.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="domain">
        <text evidence="7">The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the DEAD box helicase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="7"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627544.1">
        <property type="nucleotide sequence ID" value="XM_627544.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXB0"/>
    <dbReference type="STRING" id="353152.Q5CXB0"/>
    <dbReference type="GeneID" id="3376125"/>
    <dbReference type="KEGG" id="cpv:cgd6_1780"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1780"/>
    <dbReference type="InParanoid" id="Q5CXB0"/>
    <dbReference type="OMA" id="HEISNNC"/>
    <dbReference type="OrthoDB" id="337625at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd00268">
        <property type="entry name" value="DEADc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044742">
        <property type="entry name" value="DEAD/DEAH_RhlB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24031">
        <property type="entry name" value="RNA HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 6 10" id="KW-0347">Helicase</keyword>
    <keyword evidence="2 6" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="8">
        <location>
            <begin position="54"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="9">
        <location>
            <begin position="343"/>
            <end position="491"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365068"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="581" mass="66443" checksum="8C1071D8264E7790" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXB1</accession>
    <name>Q5CXB1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein with C2H2 Zn finger, ASR2B-like N-and C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_1770</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ARS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627543.1">
        <property type="nucleotide sequence ID" value="XM_627543.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXB1"/>
    <dbReference type="STRING" id="353152.Q5CXB1"/>
    <dbReference type="GeneID" id="3376124"/>
    <dbReference type="KEGG" id="cpv:cgd6_1770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1770"/>
    <dbReference type="InParanoid" id="Q5CXB1"/>
    <dbReference type="OMA" id="KSAPYER"/>
    <dbReference type="OrthoDB" id="342064at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016604">
        <property type="term" value="C:nuclear body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031053">
        <property type="term" value="P:primary miRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039727">
        <property type="entry name" value="SE/Ars2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007042">
        <property type="entry name" value="SERRATE/Ars2_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021933">
        <property type="entry name" value="SERRATE/Ars2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013087">
        <property type="entry name" value="Znf_C2H2_type"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165">
        <property type="entry name" value="ARSENITE-RESISTANCE PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13165:SF0">
        <property type="entry name" value="SERRATE RNA EFFECTOR MOLECULE HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04959">
        <property type="entry name" value="ARS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12066">
        <property type="entry name" value="SERRATE_Ars2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00028">
        <property type="entry name" value="ZINC_FINGER_C2H2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C2H2-type" evidence="4">
        <location>
            <begin position="546"/>
            <end position="567"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005407"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS00028"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="668" mass="77729" checksum="A8945B24901339ED" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXS5</accession>
    <name>Q5CXS5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">VASt domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_5120</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90469.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628655.1">
        <property type="nucleotide sequence ID" value="XM_628653.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXS5"/>
    <dbReference type="GeneID" id="3372087"/>
    <dbReference type="KEGG" id="cpv:cgd7_5120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5120"/>
    <dbReference type="InParanoid" id="Q5CXS5"/>
    <dbReference type="OMA" id="MHENITE"/>
    <dbReference type="OrthoDB" id="336732at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="20"/>
            <end position="47"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90469.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="503" mass="58022" checksum="8CC85071EEEB3AAD" modified="2005-04-12" version="1">MYPEIISNKLPVLIKLLIDQYISIFSSPLFLCLSILLALVVLIDFIIRKNNAKKYSSYSLNNRQNVVQNSKHIRKFVEQTKISFGCCWRYESKKRIHGRMFVNDRSITFFSPISITYEDEEFISKYSSFPGMLISDVTRITLEYTQISRMIRRGGNKVLRGSVTFEIHNNSEIPLELMFCHFFHTKYVYDLLSKLCTLSCSRIHETILGDKNNPDLNNIVHEKVNSIEDLENIGKLDQKTESIIPNEPCNFLLYNIQDRISISNSCDLDQQNIYGILAKKASNDFEEFINEYDFNSIPTSSLSNVFPCVIIPLKVQKIFSILSNHTMDSSKNVYLKYLELSGASNIQIESKPCNGDFMFHYIYKYEKSLSLTGSFGFGWLSKGMMNIKCQEDLKLYNLGSDVGILLCIDINSTGIPENDAFTVNIRHRFTPFTTVSNANSSVNMDNQISNKQEDQQNNFVQLDVECDVTFYRFSFFKSPVVQNAIDQTKKGLELIRSSWKMHY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXU0</accession>
    <name>Q5CXU0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Not4hp/Mot2p, RING finger+RRM domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_4960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90459.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628640.1">
        <property type="nucleotide sequence ID" value="XM_628638.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXU0"/>
    <dbReference type="STRING" id="353152.Q5CXU0"/>
    <dbReference type="GeneID" id="3372232"/>
    <dbReference type="KEGG" id="cpv:cgd7_4960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4960"/>
    <dbReference type="InParanoid" id="Q5CXU0"/>
    <dbReference type="OMA" id="NCKEISP"/>
    <dbReference type="OrthoDB" id="1923159at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030014">
        <property type="term" value="C:CCR4-NOT complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd16618">
        <property type="entry name" value="mRING-HC-C4C4_CNOT4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039780">
        <property type="entry name" value="Mot2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039515">
        <property type="entry name" value="NOT4_mRING-HC-C4C4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12603:SF0">
        <property type="entry name" value="CCR4-NOT TRANSCRIPTION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14570">
        <property type="entry name" value="zf-RING_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1" id="KW-0862">Zinc</keyword>
    <keyword evidence="1" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="4">
        <location>
            <begin position="50"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="5">
        <location>
            <begin position="165"/>
            <end position="244"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="299"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="1"/>
            <end position="13"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="299"/>
            <end position="313"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="322"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="341"/>
            <end position="356"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="361"/>
            <end position="373"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90459.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="684" mass="78215" checksum="1EE5B0FE3176A156" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXY4</accession>
    <name>Q5CXY4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Elongation factor EF1-gamma (Glutathione S-transferase family)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_4450</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90421.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628596.1">
        <property type="nucleotide sequence ID" value="XM_628594.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXY4"/>
    <dbReference type="FunCoup" id="Q5CXY4">
        <property type="interactions" value="398"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXY4"/>
    <dbReference type="GeneID" id="3372175"/>
    <dbReference type="KEGG" id="cpv:cgd7_4450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4450"/>
    <dbReference type="InParanoid" id="Q5CXY4"/>
    <dbReference type="OMA" id="VQWATEN"/>
    <dbReference type="OrthoDB" id="249703at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016740">
        <property type="term" value="F:transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003746">
        <property type="term" value="F:translation elongation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.1010:FF:000001">
        <property type="entry name" value="Elongation factor 1-gamma 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1050.130">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.1010">
        <property type="entry name" value="Translation elongation factor EF1B, gamma chain, conserved domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050802">
        <property type="entry name" value="EF-GSTs"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001662">
        <property type="entry name" value="EF1B_G_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036433">
        <property type="entry name" value="EF1B_G_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010987">
        <property type="entry name" value="Glutathione-S-Trfase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036282">
        <property type="entry name" value="Glutathione-S-Trfase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004046">
        <property type="entry name" value="GST_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43986:SF1">
        <property type="entry name" value="ELONGATION FACTOR 1-GAMMA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00647">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00043">
        <property type="entry name" value="GST_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01183">
        <property type="entry name" value="EF1G"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF89942">
        <property type="entry name" value="eEF1-gamma domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47616">
        <property type="entry name" value="GST C-terminal domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50040">
        <property type="entry name" value="EF1G_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50405">
        <property type="entry name" value="GST_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 3 7" id="KW-0251">Elongation factor</keyword>
    <keyword evidence="2 3" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="GST C-terminal" evidence="6">
        <location>
            <begin position="82"/>
            <end position="208"/>
        </location>
    </feature>
    <feature type="domain" description="EF-1-gamma C-terminal" evidence="5">
        <location>
            <begin position="222"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="201"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="201"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="215"/>
            <end position="225"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022768"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50040"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50405"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90421.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="382" mass="43089" checksum="F27CBD677C9FACB3" modified="2005-04-12" version="1">MVYTLFGLDSCPLVSIIKSVAEITGDKISHKVSDGTDHKDLDFHLAFGTPVLDTQFGKIFGTSTILRFLARGSPYTNLYGRTDSDATHVDMILQYIDTTLSSLVVPLFKKSGDVKSYGSELTKIFESFNKYFNYRTFVAGERITIADVLLATIIDCSIKCSAGALSLKSCVNLQRYIDTILAQPSIKKHYGEYVKKCSASKDSQAKPQSGSADASEEKPKKKDNPLDSLPPTSMSMDEWKRVYSNTKDLKGVAMPWLYQNFDANGYSFYYMKYNKLPDELDVAFRASNMVGGFLQRLDNNFRKYSFGVINIVGEGNNFDYQGVFMFRGADIPEEMQSHPSYEYHTFTKLDISKPADKKLITDYFCNDDEVEGLKIQDCKVWK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY23</accession>
    <name>Q5CY23_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">PX and WD40 domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_3980</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90387.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628557.1">
        <property type="nucleotide sequence ID" value="XM_628555.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY23"/>
    <dbReference type="GeneID" id="3372063"/>
    <dbReference type="KEGG" id="cpv:cgd7_3980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3980"/>
    <dbReference type="InParanoid" id="Q5CY23"/>
    <dbReference type="OMA" id="IMNICED"/>
    <dbReference type="OrthoDB" id="430293at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005769">
        <property type="term" value="C:early endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005770">
        <property type="term" value="C:late endosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035091">
        <property type="term" value="F:phosphatidylinositol binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045022">
        <property type="term" value="P:early endosome to late endosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008333">
        <property type="term" value="P:endosome to lysosome transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006622">
        <property type="term" value="P:protein targeting to lysosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd06093">
        <property type="entry name" value="PX_domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1520.10">
        <property type="entry name" value="Phox-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001683">
        <property type="entry name" value="PX_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036871">
        <property type="entry name" value="PX_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051837">
        <property type="entry name" value="SortingNexin/PXDomain-PKLike"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999">
        <property type="entry name" value="PX SERINE/THREONINE KINASE PXK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22999:SF23">
        <property type="entry name" value="SORTING NEXIN-16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00787">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00312">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64268">
        <property type="entry name" value="PX domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50195">
        <property type="entry name" value="PX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PX" evidence="3">
        <location>
            <begin position="1"/>
            <end position="112"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90387.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="592" mass="67141" checksum="6E5B5102BBF3C95F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY38</accession>
    <name>Q5CY38_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3800</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90374.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628542.1">
        <property type="nucleotide sequence ID" value="XM_628540.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372129"/>
    <dbReference type="KEGG" id="cpv:cgd7_3800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3800"/>
    <dbReference type="InParanoid" id="Q5CY38"/>
    <dbReference type="OMA" id="NIWIQSA"/>
    <dbReference type="OrthoDB" id="340486at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="28"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90374.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2901" mass="334734" checksum="033375A901E10B4A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYH9</accession>
    <name>Q5CYH9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Hypothetical low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2270</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90253.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628401.1">
        <property type="nucleotide sequence ID" value="XM_628399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYH9"/>
    <dbReference type="GeneID" id="3372202"/>
    <dbReference type="KEGG" id="cpv:cgd7_2270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2270"/>
    <dbReference type="InParanoid" id="Q5CYH9"/>
    <dbReference type="OMA" id="TISEQWT"/>
    <dbReference type="OrthoDB" id="342662at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="80"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="159"/>
            <end position="205"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="344"/>
            <end position="364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="90"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="114"/>
            <end position="128"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="167"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="350"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90253.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="372" mass="40647" checksum="99443C413021D72F" modified="2005-04-12" version="1">MFIIERALSIFTLIYEMEAKVGLDESRIPKIGLESSVSSLNSVLDSSNKRTPSYFNTGFIPNQLVLNASLLNELRQEPCGNKSISQINGDKPKKYDGKSETSNNNKYSRKNSESKNLASSSSKSQDNSRNVESEAASIIEKGQIQSVPNLELSKIASPNVSNAQTRQQNYVSSNSSSFNNKSQSNYKSNFQEVKTSSKDKNIPASSPRFVRVNTNLVESSINSYRVQNTAKSGAFPATSPQSRVYNNTNVQGTSWRTVWPNSNLMSNGGIGDALASPVSAKSINKFSPSSPQQMFSPTSYSQISSSAKYTVTPNPSVVRYIEQKSAEGLASPIGFSPLASPTYRKNVQQSRSNNNTTLPNSNLNNLTFSYKG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYM1</accession>
    <name>Q5CYM1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Trafficking protein particle complex subunit</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd7_1820</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8">May play a role in vesicular transport from endoplasmic reticulum to Golgi.</text>
    </comment>
    <comment type="subunit">
        <text evidence="8">Homodimer.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1 8">Golgi apparatus</location>
            <location evidence="1 8">cis-Golgi network</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the TRAPP small subunits family. BET3 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90223.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628359.1">
        <property type="nucleotide sequence ID" value="XM_628357.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYM1"/>
    <dbReference type="FunCoup" id="Q5CYM1">
        <property type="interactions" value="407"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYM1"/>
    <dbReference type="GeneID" id="3371743"/>
    <dbReference type="KEGG" id="cpv:cgd7_1820"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1820"/>
    <dbReference type="InParanoid" id="Q5CYM1"/>
    <dbReference type="OMA" id="MVQMQVQ"/>
    <dbReference type="OrthoDB" id="10262857at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030008">
        <property type="term" value="C:TRAPP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048193">
        <property type="term" value="P:Golgi vesicle transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016236">
        <property type="term" value="P:macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd14942">
        <property type="entry name" value="TRAPPC3_bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1380.20:FF:000001">
        <property type="entry name" value="Trafficking protein particle complex subunit BET3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1380.20">
        <property type="entry name" value="Trafficking protein particle complex subunit 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016721">
        <property type="entry name" value="Bet3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024096">
        <property type="entry name" value="NO_sig/Golgi_transp_ligand-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007194">
        <property type="entry name" value="TRAPP_component"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13048">
        <property type="entry name" value="TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04051">
        <property type="entry name" value="TRAPP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF018293">
        <property type="entry name" value="TRAPP_I_complex_Bet3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111126">
        <property type="entry name" value="Ligand-binding domain in the NO signalling and Golgi transport"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="6 8" id="KW-0931">ER-Golgi transport</keyword>
    <keyword evidence="7 8" id="KW-0333">Golgi apparatus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0813">Transport</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004222"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006218"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022892"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR018293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK90223.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="206" mass="23616" checksum="1237816133278DEF" modified="2005-04-12" version="1">MSNSSNQYKKRSEYLRMGELAFQKTEKINGEVFSLMYGSLVAQFVKDLDNAELINSKLEKIGYNIGIRLVDEFLAKSGISKCDSFRDTAEVIACVGFKMFLGITAETKDWNPEETSCVLVFNENPLADFVELPPCYSSSLNYSNMVCGVIRGALEQLQMQVVCYFVKDILRGDATNEIYLELKERLQEEFFDDDDEEEDQENEYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYQ7</accession>
    <name>Q5CYQ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_1390</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90194.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628323.1">
        <property type="nucleotide sequence ID" value="XM_628321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYQ7"/>
    <dbReference type="GeneID" id="3372240"/>
    <dbReference type="KEGG" id="cpv:cgd7_1390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1390"/>
    <dbReference type="InParanoid" id="Q5CYQ7"/>
    <dbReference type="OMA" id="HYGYFDI"/>
    <dbReference type="OrthoDB" id="343277at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009248">
        <property type="entry name" value="SbmA_BacA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05992">
        <property type="entry name" value="SbmA_BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="62"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="133"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="170"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="245"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="292"/>
            <end position="315"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90194.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="333" mass="39179" checksum="ABADB41C55404506" modified="2005-04-12" version="1">MILFSGLSRRSLIKLFLFLAAISACSVLLLYLEFSGNSQLKTFGDVLQAAVKDRSSVSASDLYTSFFALISYKLAVVFLKSVSSFLSKKSIFFWRLQLTEYFLENWENIYLIEGVSQRIQEDTMRYCRLFEKFSIFVVQDLFKLFIYLPLLLDLSKHITRTWFIPNTRHLLLVLIIINSIIGTSIIIFPSKYLSRLVYNIDKEEAAFRKNLVLFELEERDFSNFDFDGNYISVDNTHRSYYRRYYFIKILQLLHFRLSMITYWLFAHPSMVPPYTLGLLKQTMHAFDEVSSVFNFVVSHFKSLVEYIAVFLRLNLMVKQTIKAKETDKSGIYH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYS3</accession>
    <name>Q5CYS3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_1220</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90591.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628307.1">
        <property type="nucleotide sequence ID" value="XM_628305.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYS3"/>
    <dbReference type="GeneID" id="3371852"/>
    <dbReference type="KEGG" id="cpv:cgd7_1220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1220"/>
    <dbReference type="InParanoid" id="Q5CYS3"/>
    <dbReference type="OrthoDB" id="340238at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90591.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="595" mass="70016" checksum="03F8B675444B7005" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYS7</accession>
    <name>Q5CYS7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">CBF1-interacting co-repressor CIR N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_1180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90587.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628303.1">
        <property type="nucleotide sequence ID" value="XM_628301.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYS7"/>
    <dbReference type="FunCoup" id="Q5CYS7">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYS7"/>
    <dbReference type="GeneID" id="3371848"/>
    <dbReference type="KEGG" id="cpv:cgd7_1180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1180"/>
    <dbReference type="InParanoid" id="Q5CYS7"/>
    <dbReference type="OMA" id="WQNQEKI"/>
    <dbReference type="OrthoDB" id="10250354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019339">
        <property type="entry name" value="CIR_N_dom"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10197">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01083">
        <property type="entry name" value="Cir_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CBF1-interacting co-repressor CIR N-terminal" evidence="2">
        <location>
            <begin position="18"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="77"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM01083"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90587.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="227" mass="26466" checksum="91C10746F1260611" modified="2005-04-12" version="1">MNVQRISNKASVFLNHKHFHPGNSKNREKVWLAEEKLKEEERKQEELLKKRKKEWEIEELRRDLRQSNKKVKNQLKVQSEVEEVIDKSKQLHDVLVDKARANKSWVKSELYEEDVFLGNHSSVWGSYYDPNVKKWGFKCCKNLKRSSVCSAYNKSKSQISNSSYNTSISELFNSDTKYQSKSDTSEHNINNNAGLLLLNQGKPFSKQQKGVSEFLNILKQSQPKSSN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ07</accession>
    <name>Q5CZ07_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">mRNA export factor GLE1</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Nucleoporin GLE1</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd7_310</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nuclear pore complex</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the GLE1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90526.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628223.1">
        <property type="nucleotide sequence ID" value="XM_628221.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ07"/>
    <dbReference type="STRING" id="353152.Q5CZ07"/>
    <dbReference type="GeneID" id="3371901"/>
    <dbReference type="KEGG" id="cpv:cgd7_310"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_310"/>
    <dbReference type="InParanoid" id="Q5CZ07"/>
    <dbReference type="OMA" id="NITSYFM"/>
    <dbReference type="OrthoDB" id="343785at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044614">
        <property type="term" value="C:nuclear pore cytoplasmic filaments"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000822">
        <property type="term" value="F:inositol hexakisphosphate binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005543">
        <property type="term" value="F:phospholipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016973">
        <property type="term" value="P:poly(A)+ mRNA export from nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015031">
        <property type="term" value="P:protein transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.510">
        <property type="entry name" value="GLE1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012476">
        <property type="entry name" value="GLE1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038506">
        <property type="entry name" value="GLE1-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960">
        <property type="entry name" value="GLE-1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12960:SF0">
        <property type="entry name" value="MRNA EXPORT FACTOR GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07817">
        <property type="entry name" value="GLE1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="12" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0509">mRNA transport</keyword>
    <keyword evidence="7" id="KW-0906">Nuclear pore complex</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-0653">Protein transport</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0811">Translocation</keyword>
    <keyword evidence="12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="12" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="12">
        <location>
            <begin position="371"/>
            <end position="388"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="69"/>
            <end position="100"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="133"/>
            <end position="157"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="11">
        <location>
            <begin position="133"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00011056"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022816"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022927"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023132"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00026227"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00029983"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK90526.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="458" mass="54262" checksum="6A123172CB181DEC" modified="2005-04-12" version="1">MDGEKLSQDLNYLVFSWESKYVRNDKVLKEKITPIKEHNWNSEKAEQDEDIVSPIINRHIQEIEEEIQRINKENEDKRRKEEEERKIKERKEREKREQEELRLKKEQEELRLKKEKEQEELRLKKEQEELRLKKEKEQEEERQKAQEEAKRKEFNLSQDYPKNEANFETQGKAYIEKISNYQNSSEYKEIISSTESSIKSTRMNVKKTIQLSINQISSTHQQILSSSKRIKELLSGLRSSSTSITSSDTQSPMYSYGLYMAASLFIDQCWTQISAFPDSVWSYAYSCVYILDENDEFEAFLEGLMLTECRVLYSSNLEDLNKKENETEENFGKRLNSIVRFYLSINILRGNFGKIWLWLVKLLNKNSPHRLFVFVVLAVTQIVPHFFFSQFKNQFMKIIDYILRFKLPQIYTLIEGNPFPIKGQCKQLEAILSDLKSSCNAPPPSGFILKDKHLDVEC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="88" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPY2</accession>
    <name>A3FPY2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_1040</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the small GTPase superfamily. Rab family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51463.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388423.1">
        <property type="nucleotide sequence ID" value="XM_001388386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPY2"/>
    <dbReference type="STRING" id="353152.A3FPY2"/>
    <dbReference type="GeneID" id="3374642"/>
    <dbReference type="KEGG" id="cpv:cgd8_1040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1040"/>
    <dbReference type="InParanoid" id="A3FPY2"/>
    <dbReference type="OMA" id="ASQNICI"/>
    <dbReference type="OrthoDB" id="9989112at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001193">
        <property type="entry name" value="Rab family, other"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050209">
        <property type="entry name" value="Rab_GTPases_membrane_traffic"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005225">
        <property type="entry name" value="Small_GTP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001806">
        <property type="entry name" value="Small_GTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00231">
        <property type="entry name" value="small_GTP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47979">
        <property type="entry name" value="DRAB11-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00071">
        <property type="entry name" value="Ras"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00449">
        <property type="entry name" value="RASTRNSFRMNG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00177">
        <property type="entry name" value="ARF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00175">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00176">
        <property type="entry name" value="RAN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00173">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00174">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51419">
        <property type="entry name" value="RAB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51421">
        <property type="entry name" value="RAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51420">
        <property type="entry name" value="RHO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="184"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="184"/>
            <end position="203"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51463.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="216" mass="23972" checksum="3FCC72D31522F7FB" modified="2007-04-03" version="1">MSRQEKEQYDYLFKFIVIGDAGAGKSCLLHQFIENKFKKGSSHTIGVEFGSKIITAGGKRIKLQIWDTAGQERYRSVTRSYYRGAAGALIVYDITNRESYNHLVNWLADARTLARVDISIIGVGNKLDLKDKRQVTFLEASRCAQENDILFLETSALTGEGVEEVFVKVTRLILSKIEDGTIDPSTMTSSGVQAPSRAQLTSSSKDDETRSSGRCC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPY6</accession>
    <name>A3FPY6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Activator of Hsp90 ATPase AHSA1-like N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_2120</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the AHA1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388427.1">
        <property type="nucleotide sequence ID" value="XM_001388390.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPY6"/>
    <dbReference type="STRING" id="353152.A3FPY6"/>
    <dbReference type="GeneID" id="3374646"/>
    <dbReference type="KEGG" id="cpv:cgd8_2120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2120"/>
    <dbReference type="InParanoid" id="A3FPY6"/>
    <dbReference type="OMA" id="NMSICYS"/>
    <dbReference type="OrthoDB" id="298012at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001671">
        <property type="term" value="F:ATPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051087">
        <property type="term" value="F:protein-folding chaperone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.15.10.20">
        <property type="entry name" value="Activator of Hsp90 ATPase Aha1, N-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036338">
        <property type="entry name" value="Aha1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015310">
        <property type="entry name" value="AHSA1-like_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050754">
        <property type="entry name" value="FKBP4/5/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46512:SF8">
        <property type="entry name" value="PEPTIDYLPROLYL ISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09229">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01000">
        <property type="entry name" value="Aha1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103111">
        <property type="entry name" value="Activator of Hsp90 ATPase, Aha1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="118"/>
            <end position="151"/>
        </location>
    </feature>
    <feature type="domain" description="Activator of Hsp90 ATPase AHSA1-like N-terminal" evidence="4">
        <location>
            <begin position="363"/>
            <end position="513"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="48"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="215"/>
            <end position="268"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="222"/>
            <end position="234"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="235"/>
            <end position="267"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01000"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="514" mass="59364" checksum="71774A73AF934024" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPZ5</accession>
    <name>A3FPZ5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">peptidyl-tRNA hydrolase</fullName>
            <ecNumber evidence="1">3.1.1.29</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_3410</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="3">
            <text>an N-acyl-L-alpha-aminoacyl-tRNA + H2O = an N-acyl-L-amino acid + a tRNA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:54448"/>
            <dbReference type="Rhea" id="RHEA-COMP:10123"/>
            <dbReference type="Rhea" id="RHEA-COMP:13883"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:59874"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:138191"/>
            <dbReference type="EC" id="3.1.1.29"/>
        </reaction>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.1.29" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51476.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388436.1">
        <property type="nucleotide sequence ID" value="XM_001388399.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPZ5"/>
    <dbReference type="FunCoup" id="A3FPZ5">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPZ5"/>
    <dbReference type="GeneID" id="3374655"/>
    <dbReference type="KEGG" id="cpv:cgd8_3410"/>
    <dbReference type="InParanoid" id="A3FPZ5"/>
    <dbReference type="OMA" id="QQNIDHM"/>
    <dbReference type="OrthoDB" id="201213at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004045">
        <property type="term" value="F:peptidyl-tRNA hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1490.10">
        <property type="entry name" value="Bit1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023476">
        <property type="entry name" value="Pep_tRNA_hydro_II_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002833">
        <property type="entry name" value="PTH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042237">
        <property type="entry name" value="PTRHD1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46194:SF1">
        <property type="entry name" value="PEPTIDYL-TRNA HYDROLASE PTRHD1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01981">
        <property type="entry name" value="PTH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF102462">
        <property type="entry name" value="Peptidyl-tRNA hydrolase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00013260"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00048707"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAZ51476.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="102" mass="11490" checksum="D5F9795A88DC9959" modified="2007-04-03" version="1" fragment="single">QKEQIIQYILVRSDLGWSTGSIIAQACHASSAAIFENLGEDSVKEYLKEINQMRKVVLNCPDEKTLRNVSSDLKARKVIHKLWVELPESIPTCIATIVSEIH</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ06</accession>
    <name>A3FQ06_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">tRNA synthetase class II, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd8_4870</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388447.1">
        <property type="nucleotide sequence ID" value="XM_001388410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ06"/>
    <dbReference type="STRING" id="353152.A3FQ06"/>
    <dbReference type="GeneID" id="3374361"/>
    <dbReference type="KEGG" id="cpv:cgd8_4870"/>
    <dbReference type="InParanoid" id="A3FQ06"/>
    <dbReference type="OMA" id="EYSYISC"/>
    <dbReference type="OrthoDB" id="25675at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004812">
        <property type="term" value="F:aminoacyl-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006984">
        <property type="entry name" value="Fcf1/UTP23"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12416">
        <property type="entry name" value="RRNA-PROCESSING PROTEIN UTP23 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04900">
        <property type="entry name" value="Fcf1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="3" id="KW-0698">rRNA processing</keyword>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="216" mass="24643" checksum="120034EC41C7FD7F" modified="2007-04-03" version="1" fragment="single">MAALKNKIHIKEQFPKILNGKTTPIITDCIYKEIEMLNNLESKKADFSGAKLIARGYFRHKCGHTYCNENISNIEHKISLITNSQDISSDQEDQTEKDTISEVNNAGNQNIPRTFDSFRCILDVISKDNNSKKFIVASQDPLLRKKLHKVPGVPLIYLNNQVPILEQPSTASYNHKFASEEHRMGPQKWEYSLIPSLKSLIQNNNNLDNNESQESK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ73</accession>
    <name>A3FQ73_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Stress-induced protein sti1-like protein, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_1850</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51382.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388209.1">
        <property type="nucleotide sequence ID" value="XM_001388172.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ73"/>
    <dbReference type="SMR" id="A3FQ73"/>
    <dbReference type="STRING" id="353152.A3FQ73"/>
    <dbReference type="GeneID" id="3373446"/>
    <dbReference type="KEGG" id="cpv:cgd2_1850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1850"/>
    <dbReference type="InParanoid" id="A3FQ73"/>
    <dbReference type="OMA" id="WERREFI"/>
    <dbReference type="OrthoDB" id="2423701at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051879">
        <property type="term" value="F:Hsp90 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.25.40.10:FF:000010">
        <property type="entry name" value="Stress-induced phosphoprotein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.260.100:FF:000002">
        <property type="entry name" value="Stress-induced-phosphoprotein 1 (Hsp70/Hsp90-organizing)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.260.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041243">
        <property type="entry name" value="STI1/HOP_DP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006636">
        <property type="entry name" value="STI1_HS-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904:SF523">
        <property type="entry name" value="STRESS-INDUCED-PHOSPHOPROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22904">
        <property type="entry name" value="TPR REPEAT CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17830">
        <property type="entry name" value="STI1-HOP_DP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00515">
        <property type="entry name" value="TPR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13414">
        <property type="entry name" value="TPR_11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13432">
        <property type="entry name" value="TPR_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00727">
        <property type="entry name" value="STI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="6"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50293">
        <property type="entry name" value="TPR_REGION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 5" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="5"/>
            <end position="38"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="80"/>
            <end position="113"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="140"/>
            <end position="173"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="174"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="repeat" description="TPR" evidence="5">
        <location>
            <begin position="208"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="domain" description="STI1" evidence="7">
        <location>
            <begin position="275"/>
            <end position="314"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="6">
        <location>
            <begin position="93"/>
            <end position="132"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAZ51382.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="326" mass="37658" checksum="70566B61D303EE5A" modified="2007-04-03" version="1">MTKTAEFYKNKGNELYKQKKFDEALVQYDLAIEIDPNDISFLTNKGAVYLEMGEYQKCLEVCMQALEKRFEVKADFTKVAKAYNRMASCYIKMNELQKAKEMYEKSLLEDNNRHTRTSLKELERLIEKAEKEAYINPELAEKHRIEGNDLFKQKNYPAAKKEYDEAIKRNPSDSRLYSNRAACYMQLLEYPSALIDVQKALDLDPKFTKAWSRKGNIHYFLKEYHKALHAYQEGLKCDPDNKECNEGLKNTMAKIQQVSSSDQIDEEQVAHALADPEIQSLLSDPQFRLVLEQLKQNPATLTQVIQDPTIANGIQKLMAAGILRMG</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ87</accession>
    <name>A3FQ87_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">Phosphatidate cytidylyltransferase, mitochondrial</fullName>
            <ecNumber evidence="6">2.7.7.41</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="18">CDP-diacylglycerol synthase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="19" type="ORF">cgd2_2740</name>
    </gene>
    <organism evidence="19 20">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="19 20" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="20">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="4">Lipid metabolism.</text>
    </comment>
    <comment type="pathway">
        <text evidence="3">Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
            <topology evidence="2">Peripheral membrane protein</topology>
            <orientation evidence="2">Matrix side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the TAM41 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="19">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.41" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAZ51396.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388223.1">
        <property type="nucleotide sequence ID" value="XM_001388186.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ87"/>
    <dbReference type="STRING" id="353152.A3FQ87"/>
    <dbReference type="GeneID" id="3373549"/>
    <dbReference type="KEGG" id="cpv:cgd2_2740"/>
    <dbReference type="InParanoid" id="A3FQ87"/>
    <dbReference type="OMA" id="QAFNTRM"/>
    <dbReference type="OrthoDB" id="341477at2759"/>
    <dbReference type="UniPathway" id="UPA00557">
        <property type="reaction ID" value="UER00614"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004605">
        <property type="term" value="F:phosphatidate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032049">
        <property type="term" value="P:cardiolipin biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016024">
        <property type="term" value="P:CDP-diacylglycerol biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniPathway"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015222">
        <property type="entry name" value="Tam41"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13619:SF0">
        <property type="entry name" value="PHOSPHATIDATE CYTIDYLYLTRANSFERASE, MITOCHONDRIAL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF09139">
        <property type="entry name" value="Tam41_Mmp37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="13" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="15" id="KW-0472">Membrane</keyword>
    <keyword evidence="14" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="11" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="10" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="16" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="17" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="20" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="19">
        <location>
            <position position="121"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004443"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005119"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00005189"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00005458"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012487"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00018337"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022792"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00029893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="EMBL" id="EAZ51396.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="121" mass="14285" checksum="6295C86C7AC96AD9" modified="2007-04-03" version="1" fragment="single">VLNLLYLDFVIYCKIHSNQAFNTRMHDFIVVIDGGLEKAIKWHQMMMTDYPYHYSRISIFGPKYISKFQRFSKLCPIFYNSCVIANEKKVIKYGVISKDDLANALTNWTSPFVLNRFQKMV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQC8</accession>
    <name>A3FQC8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNase L inhibitor-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_980</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388150.1">
        <property type="nucleotide sequence ID" value="XM_001388113.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQC8"/>
    <dbReference type="FunCoup" id="A3FQC8">
        <property type="interactions" value="501"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQC8"/>
    <dbReference type="GeneID" id="3371492"/>
    <dbReference type="KEGG" id="cpv:cgd1_980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_980"/>
    <dbReference type="InParanoid" id="A3FQC8"/>
    <dbReference type="OMA" id="MVCIQNG"/>
    <dbReference type="OrthoDB" id="6593433at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0060255">
        <property type="term" value="P:regulation of macromolecule metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd03236">
        <property type="entry name" value="ABC_RNaseL_inhibitor_domain1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000144">
        <property type="entry name" value="ATP-binding cassette sub-family E member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000152">
        <property type="entry name" value="ATP-binding cassette, sub-family E, member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017896">
        <property type="entry name" value="4Fe4S_Fe-S-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017900">
        <property type="entry name" value="4Fe4S_Fe_S_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013283">
        <property type="entry name" value="RLI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034348">
        <property type="entry name" value="RLI_dom_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007209">
        <property type="entry name" value="RNaseL-inhib-like_metal-bd_dom"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF009945">
        <property type="entry name" value="PRK13409.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19248">
        <property type="entry name" value="ATP-BINDING TRANSPORT PROTEIN-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00037">
        <property type="entry name" value="Fer4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04068">
        <property type="entry name" value="Fer4_RLI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01868">
        <property type="entry name" value="ABCEFAMILY"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54862">
        <property type="entry name" value="4Fe-4S ferredoxins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00198">
        <property type="entry name" value="4FE4S_FER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51379">
        <property type="entry name" value="4FE4S_FER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="4Fe-4S ferredoxin-type" evidence="4">
        <location>
            <begin position="59"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="83"/>
            <end position="328"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="3">
        <location>
            <begin position="354"/>
            <end position="583"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="618" mass="69577" checksum="01EF5B8F6F6DDDC5" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="68" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQD3</accession>
    <name>A3FQD3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">non-specific serine/threonine protein kinase</fullName>
            <ecNumber evidence="2">2.7.11.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd1_1490</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="9">
            <text>L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:17989"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)</text>
            <dbReference type="Rhea" id="RHEA:46608"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="2.7.11.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.11.1" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51332.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388155.1">
        <property type="nucleotide sequence ID" value="XM_001388118.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQD3"/>
    <dbReference type="STRING" id="353152.A3FQD3"/>
    <dbReference type="GeneID" id="3371487"/>
    <dbReference type="KEGG" id="cpv:cgd1_1490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1490"/>
    <dbReference type="InParanoid" id="A3FQD3"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd08217">
        <property type="entry name" value="STKc_Nek2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.200.20:FF:000097">
        <property type="entry name" value="Probable serine/threonine-protein kinase nek1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051131">
        <property type="entry name" value="NEK_Ser/Thr_kinase_NIMA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899">
        <property type="entry name" value="CAMK FAMILY PROTEIN KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR44899:SF10">
        <property type="entry name" value="NIMA-RELATED KINASE 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="6" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="10">
        <location>
            <begin position="16"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012513"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00047899"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00048679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51332.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="555" mass="63995" checksum="6D2C0D457E08E164" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQD4</accession>
    <name>A3FQD4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Pre-mRNA-processing factor 17</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd1_1800</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51333.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388156.1">
        <property type="nucleotide sequence ID" value="XM_001388119.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQD4"/>
    <dbReference type="FunCoup" id="A3FQD4">
        <property type="interactions" value="394"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQD4"/>
    <dbReference type="GeneID" id="3371486"/>
    <dbReference type="KEGG" id="cpv:cgd1_1800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1800"/>
    <dbReference type="InParanoid" id="A3FQD4"/>
    <dbReference type="OMA" id="AMWDVEA"/>
    <dbReference type="OrthoDB" id="10257301at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00200">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.130.10.10:FF:000034">
        <property type="entry name" value="Pre-mRNA-processing factor 17, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032847">
        <property type="entry name" value="PRPF17"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43979:SF1">
        <property type="entry name" value="PRE-MRNA-PROCESSING FACTOR 17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="7"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50294">
        <property type="entry name" value="WD_REPEATS_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <keyword evidence="2 9" id="KW-0853">WD repeat</keyword>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="200"/>
            <end position="233"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="242"/>
            <end position="286"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="329"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="431"/>
            <end position="459"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="9">
        <location>
            <begin position="460"/>
            <end position="493"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00068146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51333.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="493" mass="56861" checksum="1E2C6B36EB62790E" modified="2007-04-03" version="1">MFEKDDSANINQLLQKSSAPDVDDAIFNHYDLNKVTLNEQINSFSCSSTAFDLNFNFQNKNISSKKVDKRTKFGQKQEIYFENLSQHIGEKKLKPSSKKSKYNYIGPWRKDQKEKVITENIIFRTEEDFGVNNLESEFNDETQESDTDDSLTDEKYAESTFLGKERTDYQNRSWIISPNETKERLPNEQCYAPKKLIKVIRAHSLGVQAIRFIPKTGHLLLSAGLDSQIKIWSSDSKCIYIYHGHKNAVRDIQFSNKQRDCKSFYSCGYDKQILFWDAEYGKTKWKILNDKTPYCVSVHPKNEQSIIVGFSNKKAIQYDTRSNEVVQVYNEHQGAVNTVTFCEDGKKFVTTSDDKKMFVWDVGIPIVVKHIADPLMQSMPYVALHSDGQHLVCQSMDNKILVYDTHANYRCIKKRFTGLKNSGYAIQCDVSPDGQYIISGDINGKVHFWDWKTTKNFRSFNAHEGVSIGCQWHPVFPSRIASCGWDGTIKIWE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQF0</accession>
    <name>A3FQF0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Sm domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd1_2690</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388172.1">
        <property type="nucleotide sequence ID" value="XM_001388135.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQF0"/>
    <dbReference type="FunCoup" id="A3FQF0">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQF0"/>
    <dbReference type="GeneID" id="3371398"/>
    <dbReference type="KEGG" id="cpv:cgd1_2690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2690"/>
    <dbReference type="InParanoid" id="A3FQF0"/>
    <dbReference type="OMA" id="PVMYKGY"/>
    <dbReference type="OrthoDB" id="409625at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034715">
        <property type="term" value="C:pICln-Sm protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005685">
        <property type="term" value="C:U1 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016487">
        <property type="entry name" value="Lsm6/sSmF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021:SF0">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11021">
        <property type="entry name" value="SMALL NUCLEAR RIBONUCLEOPROTEIN F SNRNP-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF006609">
        <property type="entry name" value="snRNP_SmF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="2 4" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="1 4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="5">
        <location>
            <begin position="1"/>
            <end position="52"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRNR" id="PIRNR006609"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAZ51349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="67" mass="7913" checksum="8623DB1665426392" modified="2007-04-03" version="1">MRYKGTLVSFDEYMNILLNDCEEWIDNTKKGTLGKVFIRCNNVLYISRAEESKETKTEIQKDEEMAE</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQG4</accession>
    <name>A3FQG4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_230</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51270.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388248.1">
        <property type="nucleotide sequence ID" value="XM_001388211.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQG4"/>
    <dbReference type="STRING" id="353152.A3FQG4"/>
    <dbReference type="GeneID" id="3373033"/>
    <dbReference type="KEGG" id="cpv:cgd5_230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_230"/>
    <dbReference type="InParanoid" id="A3FQG4"/>
    <dbReference type="OMA" id="AYRQDES"/>
    <dbReference type="OrthoDB" id="343172at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="56"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="126"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="356"/>
            <end position="375"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="389"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="432"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="234"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="12"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="13"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="56"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="129"/>
            <end position="139"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="142"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="356"/>
            <end position="368"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="451"/>
            <end position="464"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAZ51270.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="464" mass="53116" checksum="A9D5C4CECDF9B3C0" modified="2007-04-03" version="1">MRNNIDSLFNEGNNEKYDQGINEDHRVSIGSGKSIRNNNGSDLDITNIIDYSSSLNNNNNNNNNNRQSVSSINSNLPENSSNKGLFDELEEELYKDSIDSKFDSLKINNKERVTINETLDGDLTLSEINNNKNSHQNNNMSERLDKSEDRRTSLLSNDQNSFTDDSIFNVNNSFGSNMANYSAYDSVHEINLGSNQKIENHENVLLNRMIDNQGIYNDINIMCETLSTTIKDNFQIHNNEIKNLTNKINSIEDKLNELILLFNTKMKSLSNGNNVSFQSNNGNQYSQFNDRNNVNLGVGSDYVIDNNNNRNFGQNIGNIRQNQLFSNNNNNNILGQNSYLQKYDIDNDNIFGNAGLNNGSKMNSNSIRDSQKEAEKRAEIERLKKLEAERKKREEAERKRIEEEKRRQREEAERKMKADIKRKEIMDSLFACQVGDNGNNSEKKPSLFGDESSNTNSRRNLFDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="95" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQH3</accession>
    <name>A3FQH3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">DNA-directed RNA polymerase subunit</fullName>
            <ecNumber evidence="11">2.7.7.6</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd5_730</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="16 11">
            <text>RNA(n) + a ribonucleoside 5'-triphosphate = RNA(n+1) + diphosphate</text>
            <dbReference type="Rhea" id="RHEA:21248"/>
            <dbReference type="Rhea" id="RHEA-COMP:14527"/>
            <dbReference type="Rhea" id="RHEA-COMP:17342"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:61557"/>
            <dbReference type="ChEBI" id="CHEBI:140395"/>
            <dbReference type="EC" id="2.7.7.6"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the RNA polymerase beta' chain family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.6" evidence="11"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51279.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388257.1">
        <property type="nucleotide sequence ID" value="XM_001388220.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="A3FQH3">
        <property type="interactions" value="27"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQH3"/>
    <dbReference type="GeneID" id="3373369"/>
    <dbReference type="KEGG" id="cpv:cgd5_730"/>
    <dbReference type="InParanoid" id="A3FQH3"/>
    <dbReference type="OMA" id="CMGVSAN"/>
    <dbReference type="OrthoDB" id="270392at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005736">
        <property type="term" value="C:RNA polymerase I complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006351">
        <property type="term" value="P:DNA-templated transcription"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01435">
        <property type="entry name" value="RNAP_I_RPA1_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.40.20:FF:000019">
        <property type="entry name" value="DNA-directed RNA polymerase II subunit RPB1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.132.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.40.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.2940">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.20.50.80">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1490.180">
        <property type="entry name" value="RNA polymerase ii"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.860.120">
        <property type="entry name" value="RNA polymerase II, clamp domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.274.100">
        <property type="entry name" value="RNA polymerase Rpb1, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015699">
        <property type="entry name" value="DNA-dir_RNA_pol1_lsu_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045867">
        <property type="entry name" value="DNA-dir_RpoC_beta_prime"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000722">
        <property type="entry name" value="RNA_pol_asu"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006592">
        <property type="entry name" value="RNA_pol_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007080">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007066">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042102">
        <property type="entry name" value="RNA_pol_Rpb1_3_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007083">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007081">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044893">
        <property type="entry name" value="RNA_pol_Rpb1_clamp_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038120">
        <property type="entry name" value="Rpb1_funnel_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19376:SF11">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I SUBUNIT RPA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04997">
        <property type="entry name" value="RNA_pol_Rpb1_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00623">
        <property type="entry name" value="RNA_pol_Rpb1_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04983">
        <property type="entry name" value="RNA_pol_Rpb1_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05000">
        <property type="entry name" value="RNA_pol_Rpb1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04998">
        <property type="entry name" value="RNA_pol_Rpb1_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00663">
        <property type="entry name" value="RPOLA_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF64484">
        <property type="entry name" value="beta and beta-prime subunits of DNA dependent RNA-polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 11 14" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="8" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9 11" id="KW-0804">Transcription</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="RNA polymerase N-terminal" evidence="13">
        <location>
            <begin position="345"/>
            <end position="690"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="206"/>
            <end position="276"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="1129"/>
            <end position="1149"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="12">
        <location>
            <begin position="210"/>
            <end position="220"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="12">
        <location>
            <begin position="251"/>
            <end position="261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="1138"/>
            <end position="1149"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006460"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004279"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00663"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAZ51279.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1805" mass="203310" checksum="1380A273289BEDD4" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQI5</accession>
    <name>A3FQI5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GPN-loop GTPase</fullName>
            <ecNumber evidence="9">3.6.5.-</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd5_1900</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="8 9">Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Binds to RNA polymerase II.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 9">Belongs to the GPN-loop GTPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.5.-" evidence="9"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51291.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388269.1">
        <property type="nucleotide sequence ID" value="XM_001388232.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQI5"/>
    <dbReference type="FunCoup" id="A3FQI5">
        <property type="interactions" value="369"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQI5"/>
    <dbReference type="GeneID" id="3373357"/>
    <dbReference type="KEGG" id="cpv:cgd5_1900"/>
    <dbReference type="InParanoid" id="A3FQI5"/>
    <dbReference type="OMA" id="HEVCLEW"/>
    <dbReference type="OrthoDB" id="243313at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005525">
        <property type="term" value="F:GTP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003924">
        <property type="term" value="F:GTPase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd17870">
        <property type="entry name" value="GPN1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000888">
        <property type="entry name" value="GPN-loop GTPase 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004130">
        <property type="entry name" value="Gpn"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030230">
        <property type="entry name" value="Gpn1/Npa3/XAB1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231:SF8">
        <property type="entry name" value="GPN-LOOP GTPASE 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21231">
        <property type="entry name" value="XPA-BINDING PROTEIN 1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03029">
        <property type="entry name" value="ATP_bind_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="2 9" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 9" id="KW-0342">GTP-binding</keyword>
    <keyword evidence="4 9" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="3 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00055682"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU365059"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51291.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="326" mass="37143" checksum="3D8FF11888CDA047" modified="2007-04-03" version="1">MAGSGKTSFVSALYHHLTNEKKRVYTINLDPAVLSCPYPVNINIKSTFNYKKIMSDYGLGPNGAIMTCLSLFAVKFDQVLNILESKSDIDYVILDTPGQIEVFNWSASGSIILEGLSISFPTIVAYVVDTVRSQKPVTFMSNMLYSCSVMYRCKLPFILIFNKIDVTDHLLCTKWMKDYDLFSDSVLSSDDSYMASLSRSSALALYEFYKDLKFVGVSSFLGTGMKSFLEKLDEATEEFETQYKKWIDDRREAIKKQRENETLQKWNEISNIFKSDGVELNRDTQTPCIPEHLVEGFEESNESEDLSEIDQIEQVMLNPKGRLNFV</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQK2</accession>
    <name>A3FQK2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Mitochondrial processing peptidase beta subunit</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd5_3400</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the peptidase M16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51308.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388286.1">
        <property type="nucleotide sequence ID" value="XM_001388249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQK2"/>
    <dbReference type="FunCoup" id="A3FQK2">
        <property type="interactions" value="246"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQK2"/>
    <dbReference type="MEROPS" id="M16.003"/>
    <dbReference type="GeneID" id="3373332"/>
    <dbReference type="KEGG" id="cpv:cgd5_3400"/>
    <dbReference type="InParanoid" id="A3FQK2"/>
    <dbReference type="OMA" id="VIMNGIC"/>
    <dbReference type="OrthoDB" id="10251424at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.830.10:FF:000008">
        <property type="entry name" value="Mitochondrial-processing peptidase subunit beta"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.830.10">
        <property type="entry name" value="Metalloenzyme, LuxS/M16 peptidase-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011249">
        <property type="entry name" value="Metalloenz_LuxS/M16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050361">
        <property type="entry name" value="MPP/UQCRC_Complex"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011765">
        <property type="entry name" value="Pept_M16_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001431">
        <property type="entry name" value="Pept_M16_Zn_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007863">
        <property type="entry name" value="Peptidase_M16_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851:SF149">
        <property type="entry name" value="GH01077P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11851">
        <property type="entry name" value="METALLOPROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00675">
        <property type="entry name" value="Peptidase_M16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05193">
        <property type="entry name" value="Peptidase_M16_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF63411">
        <property type="entry name" value="LuxS/MPP-like metallohydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00143">
        <property type="entry name" value="INSULINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-0482">Metalloprotease</keyword>
    <keyword evidence="8" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="3" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="6" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="Peptidase M16 N-terminal" evidence="10">
        <location>
            <begin position="67"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase M16 C-terminal" evidence="11">
        <location>
            <begin position="208"/>
            <end position="329"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023049"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU004447"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00675"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF05193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51308.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="375" mass="42992" checksum="4C053AA8B832CFE3" modified="2007-04-03" version="1">MSLILKNSILKLGCSNLLRVLPTRYARFNSTLSFKRNDPDLKISKLSNGMRVATMKFGIDSIPNSLTFGLWVDSGSRNEDPGKNGIAHFLEHLIFKGTYNRSRKEIESQIEDLGAHLNAYTTREQTVYQIRCFNQDLPKCMDLLSDIIKNSKFCKSAIEQEKGVVLREMEEVSKSEEEIIFDDLHKEMYKNHPLGNTILGPKENILGFKREDLINYIRTNYIPEKMMILGVGNIDHNSFKNIAETYFGNDSNNSRNLLGLKGYKNINLSNSQYLNEINSDKNHPVLVHKKNNSDGKTLLAMAYNGTSWNSKDFLKVMFLQSMLGEYGTNNINRVTGYKNQIIERILSGIKDHVEFFETFNTCYKDTGKLYLHSYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQP1</accession>
    <name>A3FQP1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">dTMP kinase</fullName>
            <ecNumber evidence="3">2.7.4.9</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd5_3630</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="1">Pyrimidine metabolism; dTTP biosynthesis.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the thymidylate kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.4.9" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAZ51226.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388288.1">
        <property type="nucleotide sequence ID" value="XM_001388251.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQP1"/>
    <dbReference type="FunCoup" id="A3FQP1">
        <property type="interactions" value="308"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQP1"/>
    <dbReference type="GeneID" id="3372534"/>
    <dbReference type="KEGG" id="cpv:cgd5_3630"/>
    <dbReference type="InParanoid" id="A3FQP1"/>
    <dbReference type="OMA" id="QDETCRV"/>
    <dbReference type="OrthoDB" id="425602at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004798">
        <property type="term" value="F:dTMP kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004550">
        <property type="term" value="F:nucleoside diphosphate kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006233">
        <property type="term" value="P:dTDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006235">
        <property type="term" value="P:dTTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006227">
        <property type="term" value="P:dUDP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039430">
        <property type="entry name" value="Thymidylate_kin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018095">
        <property type="entry name" value="Thymidylate_kin_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10344:SF1">
        <property type="entry name" value="THYMIDYLATE KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02223">
        <property type="entry name" value="Thymidylate_kin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01331">
        <property type="entry name" value="THYMIDYLATE_KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="8" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 10" id="KW-0418">Kinase</keyword>
    <keyword evidence="5" id="KW-0545">Nucleotide biosynthesis</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Thymidylate kinase-like" evidence="9">
        <location>
            <begin position="2"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004992"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022727"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="Pfam" id="PF02223"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51226.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="166" mass="19163" checksum="3F8A6F6DA1A793AD" modified="2007-04-03" version="1">MLDGYLGKSIKMAPQVSHLLFTANRWELNNYIKENLENGIDVVCDRYSFSGIAYSSGAINLDFEWCKSREQGLISPDIVVFLEVNLDLSSTRSGFGVEIYENISDQISVRKVYQKFSNYSFWRNINASQSPDVSLNIYSTYYSFNSNIIFDSTYLFQLTKIKYLQN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPE6</accession>
    <name>Q5CPE6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_4580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000017">
        <property type="protein sequence ID" value="EAK87295.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625306.1">
        <property type="nucleotide sequence ID" value="XM_625306.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPE6"/>
    <dbReference type="STRING" id="353152.Q5CPE6"/>
    <dbReference type="GeneID" id="3372308"/>
    <dbReference type="KEGG" id="cpv:cgd5_4580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4580"/>
    <dbReference type="InParanoid" id="Q5CPE6"/>
    <dbReference type="OMA" id="AEWHDIN"/>
    <dbReference type="OrthoDB" id="10589226at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="44"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="48"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="91"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="157"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="195"/>
            <end position="216"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87295.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="230" mass="26403" checksum="2710B6CA9F1E69B6" modified="2005-04-12" version="1">MFIKNKIIIILLLLLFINFLFLFENITDNFLFKKDVSLIKIRNETPNEGSSSSGNKNSEGSSRGGGGRGKKKPELRLMKSLSFEGSEKSSHCHHHHHHHKRKNCVDEKRNTAYQFIPGGPTGKNMIAMVPSLPMKDPDDPRPNPSDMPSDEPSHNPDDEEPCDDDDPSHNTDDEEPCDDDDPNHNTDDEDEEEEKYQREKEKEKNENKHDQVDSGQKRRKKKEKKKVETS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPF3</accession>
    <name>Q5CPF3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87305.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625340.1">
        <property type="nucleotide sequence ID" value="XM_625340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPF3"/>
    <dbReference type="GeneID" id="3372330"/>
    <dbReference type="KEGG" id="cpv:cgd3_290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_290"/>
    <dbReference type="InParanoid" id="Q5CPF3"/>
    <dbReference type="OMA" id="SEHYFIE"/>
    <dbReference type="OrthoDB" id="344145at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="570"/>
            <end position="606"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87305.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="624" mass="75750" checksum="96D77227949361BB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPG5</accession>
    <name>Q5CPG5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">B-tubulin specific chaparone</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_140</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87319.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625328.1">
        <property type="nucleotide sequence ID" value="XM_625328.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPG5"/>
    <dbReference type="GeneID" id="3372315"/>
    <dbReference type="KEGG" id="cpv:cgd3_140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_140"/>
    <dbReference type="InParanoid" id="Q5CPG5"/>
    <dbReference type="OMA" id="CKALIFE"/>
    <dbReference type="OrthoDB" id="10253476at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048487">
        <property type="term" value="F:beta-tubulin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007023">
        <property type="term" value="P:post-chaperonin tubulin folding pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007021">
        <property type="term" value="P:tubulin complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058033">
        <property type="entry name" value="ARM_TBCD_2nd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033162">
        <property type="entry name" value="TBCD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658">
        <property type="entry name" value="BETA-TUBULIN COFACTOR D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12658:SF0">
        <property type="entry name" value="TUBULIN-SPECIFIC CHAPERONE D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23579">
        <property type="entry name" value="ARM_TBCD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25767">
        <property type="entry name" value="ARM_TBCD_2nd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="221"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="domain" description="Tubulin-folding cofactor D ARM repeats" evidence="2">
        <location>
            <begin position="397"/>
            <end position="590"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF25767"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87319.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1470" mass="170380" checksum="82D09C221FF2E187" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="128" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPI6</accession>
    <name>Q5CPI6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">DNA replication licensing factor MCM6</fullName>
            <ecNumber evidence="12">3.6.4.12</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd6_240</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="12">Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="17">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.12"/>
        </reaction>
    </comment>
    <comment type="subunit">
        <text evidence="12">Component of the MCM2-7 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 12">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the MCM family.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.12" evidence="12"/>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87359.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625363.1">
        <property type="nucleotide sequence ID" value="XM_625363.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPI6"/>
    <dbReference type="FunCoup" id="Q5CPI6">
        <property type="interactions" value="388"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPI6"/>
    <dbReference type="GeneID" id="3375654"/>
    <dbReference type="KEGG" id="cpv:cgd6_240"/>
    <dbReference type="InParanoid" id="Q5CPI6"/>
    <dbReference type="OMA" id="RHQQTDK"/>
    <dbReference type="OrthoDB" id="1744952at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042555">
        <property type="term" value="C:MCM complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990518">
        <property type="term" value="F:single-stranded 3'-5' DNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1902969">
        <property type="term" value="P:mitotic DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd17757">
        <property type="entry name" value="MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.28.10:FF:000003">
        <property type="entry name" value="DNA helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000826">
        <property type="entry name" value="Replicative DNA helicase Mcm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.870">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1640.10">
        <property type="entry name" value="mini-chromosome maintenance (MCM) complex, chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031327">
        <property type="entry name" value="MCM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008049">
        <property type="entry name" value="MCM6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041024">
        <property type="entry name" value="Mcm6_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018525">
        <property type="entry name" value="MCM_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001208">
        <property type="entry name" value="MCM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041562">
        <property type="entry name" value="MCM_lid"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033762">
        <property type="entry name" value="MCM_OB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11630:SF43">
        <property type="entry name" value="DNA REPLICATION LICENSING FACTOR MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00493">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17855">
        <property type="entry name" value="MCM_lid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17207">
        <property type="entry name" value="MCM_OB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18263">
        <property type="entry name" value="WHD_MCM6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01657">
        <property type="entry name" value="MCMFAMILY"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01662">
        <property type="entry name" value="MCMPROTEIN6"/>
    </dbReference>
    <dbReference type="SMART" id="SM00350">
        <property type="entry name" value="MCM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00847">
        <property type="entry name" value="MCM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50051">
        <property type="entry name" value="MCM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10 12" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="3 12" id="KW-0235">DNA replication</keyword>
    <keyword evidence="8 11" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="5 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="MCM C-terminal AAA(+) ATPase" evidence="14">
        <location>
            <begin position="408"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="766"/>
            <end position="831"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="979"/>
            <end position="998"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="1023"/>
            <end position="1055"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="766"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="13">
        <location>
            <begin position="783"/>
            <end position="807"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="808"/>
            <end position="817"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="13">
        <location>
            <begin position="1028"/>
            <end position="1049"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="15">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008010"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022705"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU004070"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU368064"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50051"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK87359.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1055" mass="118748" checksum="130EFE76991DE7F1" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPS8</accession>
    <name>Q5CPS8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">ER membrane protein complex subunit 2</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd4_4200</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="3">Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins.</text>
    </comment>
    <comment type="subunit">
        <text evidence="3">Component of the ER membrane protein complex (EMC).</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Endoplasmic reticulum membrane</location>
            <topology evidence="3">Peripheral membrane protein</topology>
            <orientation evidence="3">Cytoplasmic side</orientation>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the EMC2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87426.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625436.1">
        <property type="nucleotide sequence ID" value="XM_625436.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPS8"/>
    <dbReference type="FunCoup" id="Q5CPS8">
        <property type="interactions" value="170"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPS8"/>
    <dbReference type="GeneID" id="3372400"/>
    <dbReference type="KEGG" id="cpv:cgd4_4200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4200"/>
    <dbReference type="InParanoid" id="Q5CPS8"/>
    <dbReference type="OMA" id="MSDQEGW"/>
    <dbReference type="OrthoDB" id="124397at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0072546">
        <property type="term" value="C:EMC complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039856">
        <property type="entry name" value="EMC2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12760">
        <property type="entry name" value="TETRATRICOPEPTIDE REPEAT PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13181">
        <property type="entry name" value="TPR_8"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="2">
        <location>
            <begin position="114"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="317"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU367091"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87426.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="365" mass="42724" checksum="2E4E50DD7B0EA309" modified="2005-04-12" version="1">MGGAVSEQSRNTNLDQDKIMDLKEIKNLSYKELYNQFEKFKALNYVELVILLGTTLILDYNRKLGERKWDVMESIALATFHFGVKYENDGHKNKISKWQKYCMDELNKKHGSTFRYKKLVGMLLESRGEIEKALDVYKQLLKFDPEDLEIRRRVISVLFENNVSLIDEHLRECIMDINAWKMKAYYLLTHTLEYESALFCMEEILLHEPQNIDTINIIADLHLALGNYSRSRQYFCLALNIQKSNLRALWGILQCNLLKNDAYNQNHNNKSKVDNSIVSNNDHKLTQLVVKQIINIYSENDSNSNINKKDIDYDINNNNDTDNNNDTDKNNHKGNHNFNQNKIEITTSMIVSELLDYYTSRIKGL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPU5</accession>
    <name>Q5CPU5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87440.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625419.1">
        <property type="nucleotide sequence ID" value="XM_625419.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3372425"/>
    <dbReference type="KEGG" id="cpv:cgd4_3980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3980"/>
    <dbReference type="InParanoid" id="Q5CPU5"/>
    <dbReference type="OMA" id="NIECEKY"/>
    <dbReference type="OrthoDB" id="341607at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08700">
        <property type="entry name" value="VPS51_Exo84_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="68"/>
            <end position="95"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87440.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="884" mass="105264" checksum="8C042C9A5CB05FE9" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ10</accession>
    <name>Q5CQ10_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Signal peptide, predicted secreted protein of cryptosprodidium-specific FGLN gene family</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_50</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625469.1">
        <property type="nucleotide sequence ID" value="XM_625469.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ10"/>
    <dbReference type="GeneID" id="3372488"/>
    <dbReference type="KEGG" id="cpv:cgd8_50"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_50"/>
    <dbReference type="InParanoid" id="Q5CQ10"/>
    <dbReference type="OrthoDB" id="343472at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254824" evidence="3">
        <location>
            <begin position="30"/>
            <end position="502"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="372"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="87"/>
            <end position="139"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="502" mass="57970" checksum="EBD7D548B70708FF" modified="2005-04-12" version="1">MKHIELILYFLIIDIVLFLLHSGNFFASCESPNEQEVVASTSTSSDVSSVGTDLVDLTVYSSSGEKVKKDSLEKELYEFFQLTEEEQAIEVSGSSTSESNSDDEDEVEGSSSSGGRSAKRMRYTPIYGSPGEGTSSGSRHLNPYYEMPTRFAEAYDAFLKENIMKLVILEFERALFSSSTLYFTSIWRDRNSFQGKMIFLLGLLEFWENRGHSKNLAIKNIMIKYYSSTRLENRFTILKDYVGFKSSNYFTMNNFYRNINEIKCSDLKRSFAVIILLFEFDIKLLSSAFLFYLLVCSIEELKELEFKQSLELIKTNQDQLLSKILTLGKKHVRKFLKAMRENIPSMSNIKIKSYKLPIKFPLAMHKINIENFGLRFCLSLLELSLISNLSFSIFNLIFFFGSRLKFAAEVFLAFDIIKILTTAMSELSDIISAILFDEGIMRHISRGIMALHNIDISNLRSRFAECIQVKNKYHELRGLIVVTDYQRKARLKKESRRRRRRT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ16</accession>
    <name>Q5CQ16_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Chorein N-terminal domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_4490</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87594.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625610.1">
        <property type="nucleotide sequence ID" value="XM_625610.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ16"/>
    <dbReference type="GeneID" id="3372554"/>
    <dbReference type="KEGG" id="cpv:cgd5_4490"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4490"/>
    <dbReference type="InParanoid" id="Q5CQ16"/>
    <dbReference type="OMA" id="EDCCNNF"/>
    <dbReference type="OrthoDB" id="272810at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000987">
        <property type="term" value="F:cis-regulatory region sequence-specific DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000981">
        <property type="term" value="F:DNA-binding transcription factor activity, RNA polymerase II-specific"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042594">
        <property type="term" value="P:response to starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14596">
        <property type="entry name" value="ZINC FINGER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14596:SF72">
        <property type="entry name" value="ZINC FINGER PROTEIN MSN2-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="2659"/>
            <end position="2683"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="499"/>
            <end position="521"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="790"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="975"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2084"/>
            <end position="2126"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="2440"/>
            <end position="2466"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="798"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="979"/>
            <end position="1016"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1025"/>
            <end position="1036"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="2090"/>
            <end position="2126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87594.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="2691" mass="311030" checksum="135470B41596F3EF" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ50</accession>
    <name>Q5CQ50_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_4130</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87561.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625576.1">
        <property type="nucleotide sequence ID" value="XM_625576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ50"/>
    <dbReference type="GeneID" id="3372528"/>
    <dbReference type="KEGG" id="cpv:cgd5_4130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4130"/>
    <dbReference type="InParanoid" id="Q5CQ50"/>
    <dbReference type="OMA" id="GPEQNQM"/>
    <dbReference type="OrthoDB" id="341185at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="7"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="226"/>
            <end position="247"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87561.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="257" mass="28812" checksum="4CC9E56F245FF408" modified="2005-04-12" version="1">MKLSRSFIIACIFVYILNILGLVIINPKPEICLLRIRVREKGFLKRAANAAGRLIFGVDTTQKEPPLNTERFPVGMFPDPKELAQELDILENRKIVPDSNRQTGVQYISDIANGQTPNLELLSDSQMAQVSSGVFDRGSKEALEASNKTKIEELRANKEREQALQSQGQIIKDGEKVKIGKQGPVTLDDPDENNKGKTIPPKLALVDNEEEFINKDTNQSIFSHPLVIIFIFILVVCMFAGGSLIFFKKFGKKKRKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="58" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQA8</accession>
    <name>Q5CQA8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Apicomplexan specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_1440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87608.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625740.1">
        <property type="nucleotide sequence ID" value="XM_625740.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQA8"/>
    <dbReference type="FunCoup" id="Q5CQA8">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="GeneID" id="3372709"/>
    <dbReference type="KEGG" id="cpv:cgd4_1440"/>
    <dbReference type="InParanoid" id="Q5CQA8"/>
    <dbReference type="OMA" id="NWSSCHA"/>
    <dbReference type="OrthoDB" id="2135488at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056557">
        <property type="entry name" value="NELF-A_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23553">
        <property type="entry name" value="NELF-A_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NELF-A N-terminal" evidence="2">
        <location>
            <begin position="106"/>
            <end position="212"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="26"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="62"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="25"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="62"/>
            <end position="72"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="74"/>
            <end position="93"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF23553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87608.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="285" mass="33099" checksum="8A8EEB899605CAA4" modified="2005-04-12" version="1">MNKRDYSEIENSFEGKEFQEKESENKSSIIVETILNSKEGLNPTISQVNLVLDSELKSKSNLTNENNNTLELGYESEPEPENDNDNETEDDEDGYEPYIKYLQALSLSWSSCQASSMLTKDLVEYMVPRFQDCSTPIKVRIIMSILYISDSLRESCKQEFMNILNFGELDRDDWVRKLSRLMIPYVQKGVLDLGETDTETAFKILRYLDELRMRENIDFRLKPPLESIHMCDPLTDESINNELPCYNVDYDNFAPQKDFELLLAEVEKDGLHKMRIASNSFTNNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQJ7</accession>
    <name>Q5CQJ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="15">XPG, DNA excision repair protein, flap endonuclease</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="15" type="ORF">cgd4_440</name>
    </gene>
    <organism evidence="15 16">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="15 16" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="16">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="15">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87678.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625651.1">
        <property type="nucleotide sequence ID" value="XM_625651.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQJ7"/>
    <dbReference type="FunCoup" id="Q5CQJ7">
        <property type="interactions" value="168"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQJ7"/>
    <dbReference type="GeneID" id="3372731"/>
    <dbReference type="KEGG" id="cpv:cgd4_440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_440"/>
    <dbReference type="InParanoid" id="Q5CQJ7"/>
    <dbReference type="OMA" id="AKDDMDI"/>
    <dbReference type="OrthoDB" id="31113at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004520">
        <property type="term" value="F:DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd09904">
        <property type="entry name" value="H3TH_XPG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd09868">
        <property type="entry name" value="PIN_XPG_RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.150.20">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1010">
        <property type="entry name" value="5'-nuclease"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036279">
        <property type="entry name" value="5-3_exonuclease_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008918">
        <property type="entry name" value="HhH2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029060">
        <property type="entry name" value="PIN-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006086">
        <property type="entry name" value="XPG-I_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006084">
        <property type="entry name" value="XPG/Rad2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001044">
        <property type="entry name" value="XPG/Rad2_eukaryotes"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006085">
        <property type="entry name" value="XPG_DNA_repair_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171">
        <property type="entry name" value="DNA REPAIR PROTEIN COMPLEMENTING XP-G CELLS-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR16171:SF7">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00867">
        <property type="entry name" value="XPG_I"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00752">
        <property type="entry name" value="XPG_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00853">
        <property type="entry name" value="XPGRADSUPER"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00066">
        <property type="entry name" value="XRODRMPGMNTG"/>
    </dbReference>
    <dbReference type="SMART" id="SM00279">
        <property type="entry name" value="HhH2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00484">
        <property type="entry name" value="XPGI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00485">
        <property type="entry name" value="XPGN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47807">
        <property type="entry name" value="5' to 3' exonuclease, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88723">
        <property type="entry name" value="PIN domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 15" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9" id="KW-0460">Magnesium</keyword>
    <keyword evidence="6" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="10" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="5" id="KW-0540">Nuclease</keyword>
    <keyword evidence="11" id="KW-0539">Nucleus</keyword>
    <keyword evidence="4" id="KW-0597">Phosphoprotein</keyword>
    <keyword evidence="16" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="XPG N-terminal" evidence="14">
        <location>
            <begin position="1"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="domain" description="XPG-I" evidence="13">
        <location>
            <begin position="888"/>
            <end position="956"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="127"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="12">
        <location>
            <begin position="740"/>
            <end position="808"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="12">
        <location>
            <begin position="146"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="740"/>
            <end position="752"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="762"/>
            <end position="786"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="12">
        <location>
            <begin position="793"/>
            <end position="802"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00005283"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022553"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022722"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022759"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00484"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="SMART" id="SM00485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="EMBL" id="EAK87678.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1147" mass="134105" checksum="AE27B3584DF47B9C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQK3</accession>
    <name>Q5CQK3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Protein with signal peptide plus 12 transmembrane domain protein, possible transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_380</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87681.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625645.1">
        <property type="nucleotide sequence ID" value="XM_625645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQK3"/>
    <dbReference type="FunCoup" id="Q5CQK3">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQK3"/>
    <dbReference type="GeneID" id="3372734"/>
    <dbReference type="KEGG" id="cpv:cgd4_380"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_380"/>
    <dbReference type="InParanoid" id="Q5CQK3"/>
    <dbReference type="OMA" id="HQLWLMW"/>
    <dbReference type="OrthoDB" id="410267at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052983">
        <property type="entry name" value="MFS_Riboflavin_Transporter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43385:SF1">
        <property type="entry name" value="RIBOFLAVIN TRANSPORTER RIBJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="12"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="55"/>
            <end position="75"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="84"/>
            <end position="102"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="108"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="139"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="195"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="382"/>
            <end position="403"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="409"/>
            <end position="432"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="444"/>
            <end position="468"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="474"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="506"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="538"/>
            <end position="555"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="317"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="326"/>
            <end position="337"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87681.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="577" mass="65874" checksum="69E43FC5B59624F6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQN1</accession>
    <name>Q5CQN1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_70</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625617.1">
        <property type="nucleotide sequence ID" value="XM_625617.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQN1"/>
    <dbReference type="FunCoup" id="Q5CQN1">
        <property type="interactions" value="296"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQN1"/>
    <dbReference type="GeneID" id="3372724"/>
    <dbReference type="KEGG" id="cpv:cgd4_70"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_70"/>
    <dbReference type="InParanoid" id="Q5CQN1"/>
    <dbReference type="OMA" id="MFLKPYR"/>
    <dbReference type="OrthoDB" id="199771at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11608">
        <property type="entry name" value="eIF2D_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.400.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039757">
        <property type="entry name" value="EIF2D"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039759">
        <property type="entry name" value="eIF2D_SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015947">
        <property type="entry name" value="PUA-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR048248">
        <property type="entry name" value="PUA_eIF2d-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004521">
        <property type="entry name" value="Uncharacterised_CHP00451"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057429">
        <property type="entry name" value="WH_eIF2D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00451">
        <property type="entry name" value="unchar_dom_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12217:SF4">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF26292">
        <property type="entry name" value="PUA_elF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25304">
        <property type="entry name" value="WHD_eIF2D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88697">
        <property type="entry name" value="PUA domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50890">
        <property type="entry name" value="PUA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="1">
        <location>
            <begin position="631"/>
            <end position="708"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="718" mass="82488" checksum="AF7FBF87FC0E7690" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQQ0</accession>
    <name>Q5CQQ0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit C</fullName>
            <shortName evidence="4">eIF3c</shortName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="4">Eukaryotic translation initiation factor 3 subunit 8</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd4_3770</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="4">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="4">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the eIF-3 subunit C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87744.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625952.1">
        <property type="nucleotide sequence ID" value="XM_625952.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQQ0"/>
    <dbReference type="FunCoup" id="Q5CQQ0">
        <property type="interactions" value="446"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQQ0"/>
    <dbReference type="GeneID" id="3372916"/>
    <dbReference type="KEGG" id="cpv:cgd4_3770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3770"/>
    <dbReference type="InParanoid" id="Q5CQQ0"/>
    <dbReference type="OMA" id="FRCGLIK"/>
    <dbReference type="OrthoDB" id="29647at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005852">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031369">
        <property type="term" value="F:translation initiation factor binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03002">
        <property type="entry name" value="eIF3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027516">
        <property type="entry name" value="EIF3C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008905">
        <property type="entry name" value="EIF3C_N_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITATION FACTOR 3, SUBUNIT 8 EIF3S8 -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13937:SF0">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT C-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05470">
        <property type="entry name" value="eIF-3c_N"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="2 4" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 4" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="6">
        <location>
            <begin position="734"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="61"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="172"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="428"/>
            <end position="456"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="944"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="10"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="207"/>
            <end position="251"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="296"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="944"/>
            <end position="962"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="972"/>
            <end position="984"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="985"/>
            <end position="1003"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="1004"/>
            <end position="1014"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="1021"/>
            <end position="1032"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK87744.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1040" mass="116323" checksum="894B2D32B62D14B0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQZ7</accession>
    <name>Q5CQZ7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Sec7 domain containing protein, possibly of plant origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2690</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_625855.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQZ7"/>
    <dbReference type="GeneID" id="3372842"/>
    <dbReference type="KEGG" id="cpv:cgd4_2690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2690"/>
    <dbReference type="InParanoid" id="Q5CQZ7"/>
    <dbReference type="OMA" id="DISIMAN"/>
    <dbReference type="OrthoDB" id="18431at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0012505">
        <property type="term" value="C:endomembrane system"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032012">
        <property type="term" value="P:regulation of ARF protein signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016192">
        <property type="term" value="P:vesicle-mediated transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd00171">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.220.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1000.11">
        <property type="entry name" value="Arf Nucleotide-binding Site Opener,domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032691">
        <property type="entry name" value="Mon2/Sec7/BIG1-like_HUS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023394">
        <property type="entry name" value="Sec7_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000904">
        <property type="entry name" value="Sec7_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035999">
        <property type="entry name" value="Sec7_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663:SF388">
        <property type="entry name" value="GOLGI-SPECIFIC BREFELDIN A-RESISTANCE GUANINE NUCLEOTIDE EXCHANGE FACTOR 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10663">
        <property type="entry name" value="GUANYL-NUCLEOTIDE EXCHANGE FACTOR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01369">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12783">
        <property type="entry name" value="Sec7-like_HUS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00222">
        <property type="entry name" value="Sec7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48425">
        <property type="entry name" value="Sec7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50190">
        <property type="entry name" value="SEC7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SEC7" evidence="1">
        <location>
            <begin position="506"/>
            <end position="729"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50190"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1800" mass="206780" checksum="C7D0F3D35C6EB9A4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR07</accession>
    <name>Q5CR07_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">WD repeat protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2570</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87843.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625845.1">
        <property type="nucleotide sequence ID" value="XM_625845.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR07"/>
    <dbReference type="STRING" id="353152.Q5CR07"/>
    <dbReference type="GeneID" id="3372850"/>
    <dbReference type="KEGG" id="cpv:cgd4_2570"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2570"/>
    <dbReference type="InParanoid" id="Q5CR07"/>
    <dbReference type="OMA" id="MSTLAFH"/>
    <dbReference type="OrthoDB" id="6252103at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005656">
        <property type="term" value="C:nuclear pre-replicative complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0120330">
        <property type="term" value="C:rixosome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006364">
        <property type="term" value="P:rRNA processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045227">
        <property type="entry name" value="WDR18/Ipi3/RID3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763:SF0">
        <property type="entry name" value="WD REPEAT-CONTAINING PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18763">
        <property type="entry name" value="WD-REPEAT PROTEIN 18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0677">Repeat</keyword>
    <keyword evidence="1" id="KW-0853">WD repeat</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87843.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="498" mass="56027" checksum="7B3D809E562AC7F9" modified="2005-04-12" version="1">MERITLVSNHNGIYSFDRNTGTVSQTFKDCNASKFSVSFIGNSTKYLAGFQTNKSTLHIWSNKSDPIYRVSVPEIIKCCEFQDDGGIVYAGGLSGTVYIWVITTGQLLNCWLPHYKPINKIKLVQGNSILVTCSDDCYIQAFLTSELLESNNSLTFPKPLIKWNAHSASINDFFPLNLTNSFSDISIISIGGDFSLSFLTFRSEKPLANLNFSTQLCSCTSSECGKLVFIGGGNGIIYKIYYDSIPTLNSRISKLFGHSGPVKACICSKDKIFSSANDGVRIWDIITGSCIAQLPQFGDGILSILNTNLSISYLSLSIPIFKPLQRNISKYSNVIGVNIPTKDRRTDIKNEIYHLSNRIDAISYLNTSLLTFNGISKKRLSQMNTMKDSTFTSEYNNMIKLAVEKCISLESSKLRSNCSIHDNNFELLRTCTIPYSKFKEVKTIKAEEEKKVQVASQNFKNLPKIKYKFIKSCSIGKFSRKQYLRMLLRKKYLKLSRH</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="42" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR12</accession>
    <name>Q5CR12_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_2520</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625840.1">
        <property type="nucleotide sequence ID" value="XM_625840.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR12"/>
    <dbReference type="GeneID" id="3372873"/>
    <dbReference type="KEGG" id="cpv:cgd4_2520"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2520"/>
    <dbReference type="InParanoid" id="Q5CR12"/>
    <dbReference type="OMA" id="HNISIRP"/>
    <dbReference type="OrthoDB" id="343806at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254424" evidence="2">
        <location>
            <begin position="23"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="248"/>
            <end position="274"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="249"/>
            <end position="266"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="274" mass="30763" checksum="DBF5F63C65D09FA5" modified="2005-04-12" version="1">MNIKLLSFRILLLLSTVSYAYSEKKRQLMSDSEIIASINENISLLLKFERIIFTKRSDQAKKKCNIALKNLKTLNSATENRSIQINPLTSITLNGIIWHSDPCNNPDQMIKHIELYNLIIRSKTFSQISNPNQKNNSEQINMGTLTNKFFSPRNNGLKNAVFRSNTISNTLIKNKTHTKTISQGIRSKMDSLISSGDDNNSSMIDPTFNSTNVLDAGEKINPCSQNKTIDNSYATKKTIREELQELAKMKSVSSKSSTGFSESLSKILSERSAS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRA5</accession>
    <name>Q5CRA5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Putative transport protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_3580</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88047.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626281.1">
        <property type="nucleotide sequence ID" value="XM_626281.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRA5"/>
    <dbReference type="GeneID" id="3373105"/>
    <dbReference type="KEGG" id="cpv:cgd5_3580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3580"/>
    <dbReference type="InParanoid" id="Q5CRA5"/>
    <dbReference type="OMA" id="VLINIEY"/>
    <dbReference type="OrthoDB" id="10267956at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904680">
        <property type="term" value="F:peptide transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015833">
        <property type="term" value="P:peptide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009248">
        <property type="entry name" value="SbmA_BacA"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05992">
        <property type="entry name" value="SbmA_BacA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="130"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="175"/>
            <end position="195"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88047.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="340" mass="39521" checksum="09E0343AFF0B8F8F" modified="2005-04-12" version="1">MILQFFGDKKYAIWAYLGSVLILSLAIFECFFDTHSSYLVEYYANCMQSLLNPTPGGYKATVDDFIQFIYGFIWIEIAGVSLSNACRAILGNFIAFKWRTALNNYYLKKWEHLKTIEGASQRIQEDCQKFAVILETIAIEMLYWSCKTIAFYRLVVNYGRMMSYVPFFGSHSHSLLFAALSFDLLCFVPLVISGIKLPSIEYDNQVLEASYRKKLIYSEEVSVRDEDLTTIRKLFIEVRNNSFQMYKHMMFVDSASTATIFFRRYFVVFFIIPSYLKGDIDFGTYTASVAVVNNMLRILSYIRQEWSNLIELLSIKQRLDGFEVYLNDHSETQTLVGNQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRA7</accession>
    <name>Q5CRA7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">CNcl1p/MJ0026/YebU-like. SUN family methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_3560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="5">Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88233.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626279.1">
        <property type="nucleotide sequence ID" value="XM_626279.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRA7"/>
    <dbReference type="STRING" id="353152.Q5CRA7"/>
    <dbReference type="GeneID" id="3373081"/>
    <dbReference type="KEGG" id="cpv:cgd5_3560"/>
    <dbReference type="InParanoid" id="Q5CRA7"/>
    <dbReference type="OMA" id="DTRRAHM"/>
    <dbReference type="OrthoDB" id="6093671at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001510">
        <property type="term" value="P:RNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049560">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_cat"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001678">
        <property type="entry name" value="MeTrfase_RsmB-F_NOP2_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023267">
        <property type="entry name" value="RCMT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22808">
        <property type="entry name" value="NCL1 YEAST -RELATED NOL1/NOP2/FMU SUN DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01189">
        <property type="entry name" value="Methyltr_RsmB-F"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR02008">
        <property type="entry name" value="RCMTFAMILY"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51686">
        <property type="entry name" value="SAM_MT_RSMB_NOP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1 5 8" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="3 5" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="2 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="SAM-dependent MTase RsmB/NOP-type" evidence="7">
        <location>
            <begin position="35"/>
            <end position="439"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="517"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="517"/>
            <end position="529"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="5">
        <location>
            <position position="297"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <begin position="154"/>
            <end position="160"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="187"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="243"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88233.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="745" mass="86203" checksum="6FE604008E5691C8" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRF9</accession>
    <name>Q5CRF9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha amylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd5_2910</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626227.1">
        <property type="nucleotide sequence ID" value="XM_626227.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRF9"/>
    <dbReference type="STRING" id="353152.Q5CRF9"/>
    <dbReference type="GeneID" id="3373210"/>
    <dbReference type="KEGG" id="cpv:cgd5_2910"/>
    <dbReference type="InParanoid" id="Q5CRF9"/>
    <dbReference type="OMA" id="IWWQVYP"/>
    <dbReference type="OrthoDB" id="1740265at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016798">
        <property type="term" value="F:hydrolase activity, acting on glycosyl bonds"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd11353">
        <property type="entry name" value="AmyAc_euk_bac_CMD_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.80">
        <property type="entry name" value="Glycosidases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.1180">
        <property type="entry name" value="Golgi alpha-mannosidase II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.400.10">
        <property type="entry name" value="Oligo-1,6-glucosidase, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017853">
        <property type="entry name" value="GH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006047">
        <property type="entry name" value="GH13_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013780">
        <property type="entry name" value="Glyco_hydro_b"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045857">
        <property type="entry name" value="O16G_dom_2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357">
        <property type="entry name" value="ALPHA-AMYLASE FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10357:SF210">
        <property type="entry name" value="MALTODEXTRIN GLUCOSIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00128">
        <property type="entry name" value="Alpha-amylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00642">
        <property type="entry name" value="Aamy"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51445">
        <property type="entry name" value="(Trans)glycosidases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51011">
        <property type="entry name" value="Glycosyl hydrolase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Glycosyl hydrolase family 13 catalytic" evidence="3">
        <location>
            <begin position="39"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00642"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="509" mass="59619" checksum="BA93EDC2A153DA54" modified="2005-04-12" version="1" fragment="single">IIMVINGNEWYKNCNWYHIYPIGLCGVERINSDKIVRVNKLEELGSKSWIDHLKNLNIGGIYIGPVFESEAHGYDTTDLLSIDKRLGSNEDFKNLVKIYHSNGIKVIIDAVFNHVGRNFFAFNDIKINGKHSKYCDWFKGLDFSKKSQKGDNFTYTPWEGYYELVTLNHENYEVKKYLFDAVEFWFKEYEIDGLRLDAADCISIEFWRIFRDFCKTKFGENFALLAEIIHGDQRIWVRPNPSASIKYEYTNQPFDGVTNYVLWDAIWKSHRFNNLELLANVISQQNDLFSSGWMYNFVDNHDVTRIASQIEIEDDLLTVYIILFMLNGSPSIYYGSEFRFKGVKGKGRRADFQLRPKLTIKDLEWLNSDKNDGFLVLIKFISQIRGHPIIGKILTKGNYSLLLNTKTLLVFERRIKEEFIFVAINIDTKSVEDFEVDWKEKDGQWRDILSPSDTYQSKKGKIKINVLSNWAIIISSCIPKTSYNQYKIKKFKKVLYNIPTLDRSELIEN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRH1</accession>
    <name>Q5CRH1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Katanin p60/fidgetin family with AAA ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_2790</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87992.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626215.1">
        <property type="nucleotide sequence ID" value="XM_626215.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRH1"/>
    <dbReference type="STRING" id="353152.Q5CRH1"/>
    <dbReference type="GeneID" id="3373230"/>
    <dbReference type="KEGG" id="cpv:cgd5_2790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2790"/>
    <dbReference type="InParanoid" id="Q5CRH1"/>
    <dbReference type="OMA" id="ANECKAT"/>
    <dbReference type="OrthoDB" id="10251136at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:001054">
        <property type="entry name" value="ATPase, AAA family, putative"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041569">
        <property type="entry name" value="AAA_lid_3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050304">
        <property type="entry name" value="MT-severing_AAA_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074">
        <property type="entry name" value="AAA DOMAIN-CONTAINING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23074:SF17">
        <property type="entry name" value="FIDGETIN-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17862">
        <property type="entry name" value="AAA_lid_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="4 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="7">
        <location>
            <begin position="289"/>
            <end position="425"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87992.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="537" mass="61187" checksum="EFFEB0274D3B989B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRI0</accession>
    <name>Q5CRI0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2690</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87985.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626206.1">
        <property type="nucleotide sequence ID" value="XM_626206.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRI0"/>
    <dbReference type="GeneID" id="3373223"/>
    <dbReference type="KEGG" id="cpv:cgd5_2690"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2690"/>
    <dbReference type="InParanoid" id="Q5CRI0"/>
    <dbReference type="OMA" id="NTAIMIP"/>
    <dbReference type="OrthoDB" id="342323at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="263"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="141"/>
            <end position="168"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="270"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="287"/>
            <end position="307"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="308"/>
            <end position="324"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87985.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="646" mass="73260" checksum="7381F7178817CDCD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRK6</accession>
    <name>Q5CRK6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Prefoldin subunit 5</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_2430</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the prefoldin subunit alpha family.</text>
    </comment>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88213.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626180.1">
        <property type="nucleotide sequence ID" value="XM_626180.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRK6"/>
    <dbReference type="STRING" id="353152.Q5CRK6"/>
    <dbReference type="GeneID" id="3373351"/>
    <dbReference type="KEGG" id="cpv:cgd5_2430"/>
    <dbReference type="InParanoid" id="Q5CRK6"/>
    <dbReference type="OMA" id="QAKFKAC"/>
    <dbReference type="OrthoDB" id="10267474at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016272">
        <property type="term" value="C:prefoldin complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051082">
        <property type="term" value="F:unfolded protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990113">
        <property type="term" value="P:RNA polymerase I assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990114">
        <property type="term" value="P:RNA polymerase II core complex assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990115">
        <property type="term" value="P:RNA polymerase III assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd23157">
        <property type="entry name" value="Prefoldin_5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.370">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011599">
        <property type="entry name" value="PFD_alpha_archaea"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009053">
        <property type="entry name" value="Prefoldin"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004127">
        <property type="entry name" value="Prefoldin_subunit_alpha"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00293">
        <property type="entry name" value="prefoldin subunit alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12674:SF2">
        <property type="entry name" value="PREFOLDIN SUBUNIT 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02996">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46579">
        <property type="entry name" value="Prefoldin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88213.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="163" mass="18442" checksum="AC4757A2DA329FB4" modified="2005-04-12" version="1" fragment="single">IMTASNAPNNSGNKVETIQLSSLPPAKLFQLRDQTQDEMNELSIRIQQLNVVLNRFNGSREALEQLKPENKDNTILAPISQSIYVDATICDVENVLVDIGTGYHVEMRIEKAKVHFDNKIEMIKKSIEKISKSFNDKNKIFDAINSILMEQIKAQQQGIEAKK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRL3</accession>
    <name>Q5CRL3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">p27 like 26S proteasomal subunit with a PDZ domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2360</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88211.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626173.1">
        <property type="nucleotide sequence ID" value="XM_626173.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRL3"/>
    <dbReference type="FunCoup" id="Q5CRL3">
        <property type="interactions" value="295"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRL3"/>
    <dbReference type="GeneID" id="3373349"/>
    <dbReference type="KEGG" id="cpv:cgd5_2360"/>
    <dbReference type="InParanoid" id="Q5CRL3"/>
    <dbReference type="OMA" id="DWGGRGM"/>
    <dbReference type="OrthoDB" id="72325at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070682">
        <property type="term" value="P:proteasome regulatory particle assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.42.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.140.1710">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040815">
        <property type="entry name" value="Nas2_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036034">
        <property type="entry name" value="PDZ_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035269">
        <property type="entry name" value="PSMD9"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12651:SF1">
        <property type="entry name" value="26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 9"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF18265">
        <property type="entry name" value="Nas2_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50156">
        <property type="entry name" value="PDZ domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0143">Chaperone</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Nas2 N-terminal" evidence="2">
        <location>
            <begin position="14"/>
            <end position="93"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF18265"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88211.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="249" mass="28250" checksum="E6217624E6D9DA08" modified="2005-04-12" version="1" fragment="single">NTNNTRYNINVNMEELAKRKGEIEKEVSELTEFLNSCGPDVGISGKLVDSEGFPRSDIDIYAVRRARNRIALLNTDYSNVMKEIEEKLFDIHSKEKTYVPINKSEKSQRCNASECLNYPFGYVNSVLEGSPAFQSGIRTGDLLLEFGSLKSESELHSQEESKHLIGQLPGIVQDNLDKSIKVTLLRSNSKQPEELLSEFSTFIDNSNLSYKDLNLLEFEKKSIDLVPKKWQGKGYLGCNIAFLHKFVEK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRM5</accession>
    <name>Q5CRM5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane associated thioredoxin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_2230</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87955.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626161.1">
        <property type="nucleotide sequence ID" value="XM_626161.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRM5"/>
    <dbReference type="SMR" id="Q5CRM5"/>
    <dbReference type="STRING" id="353152.Q5CRM5"/>
    <dbReference type="GeneID" id="3373118"/>
    <dbReference type="KEGG" id="cpv:cgd5_2230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2230"/>
    <dbReference type="InParanoid" id="Q5CRM5"/>
    <dbReference type="OMA" id="CGSNWSL"/>
    <dbReference type="OrthoDB" id="72053at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd02961">
        <property type="entry name" value="PDI_a_family"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013766">
        <property type="entry name" value="Thioredoxin_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19991:SF2">
        <property type="entry name" value="GH08893P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19991">
        <property type="entry name" value="L 2 01289"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00085">
        <property type="entry name" value="Thioredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254297" evidence="3">
        <location>
            <begin position="21"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="209"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Thioredoxin" evidence="4">
        <location>
            <begin position="67"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="31"/>
            <end position="58"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="235"/>
            <end position="363"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="235"/>
            <end position="246"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="254"/>
            <end position="321"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="346"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF00085"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK87955.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="363" mass="42097" checksum="8F76FEB90F609A1B" modified="2005-04-12" version="1">MKLKLAVLNLILLLVIGIRGDEINASINGHNRAQRHAKPTASASSYTPQKHHPTVSVNSEKKIQSFVKELNDNNFEHLTQSATGSTTGDWFVLFYLPNCQQSQMSLVELDKLSVIARESLNVAKIDVSKNQQLINRFGIVAVPSFRFFRNGKMYTYTGMRNAEVIKAFIWNKDYKKLTPQPVPDPLSTLDIIISEIKHTINDINKLIKLAPLVTIIILLIGFFTGIGVTNIFSRNSNRSKTTTSNNRVKRDKYSDDECEDHEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEEAPKQLKTPQRGRRAAENIAKEDDRLNNTYNTSVRRSNRLKKL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRP0</accession>
    <name>Q5CRP0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88063.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626146.1">
        <property type="nucleotide sequence ID" value="XM_626146.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRP0"/>
    <dbReference type="GeneID" id="3373262"/>
    <dbReference type="KEGG" id="cpv:cgd5_2060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2060"/>
    <dbReference type="InParanoid" id="Q5CRP0"/>
    <dbReference type="OrthoDB" id="340261at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253774" evidence="2">
        <location>
            <begin position="20"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="505"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="617"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="510"/>
            <end position="548"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88063.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="617" mass="69181" checksum="123340B73D234A43" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRS1</accession>
    <name>Q5CRS1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="11">CTP synthase</fullName>
            <ecNumber evidence="11">6.3.4.2</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="11">UTP--ammonia ligase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd5_1710</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="11">Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="10 11">
            <text>UTP + L-glutamine + ATP + H2O = CTP + L-glutamate + ADP + phosphate + 2 H(+)</text>
            <dbReference type="Rhea" id="RHEA:26426"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29985"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:37563"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:46398"/>
            <dbReference type="ChEBI" id="CHEBI:58359"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="6.3.4.2"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="1 11">Pyrimidine metabolism; CTP biosynthesis via de novo pathway; CTP from UDP: step 2/2.</text>
    </comment>
    <comment type="similarity">
        <text evidence="2 11">Belongs to the CTP synthase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.3.4.2" evidence="11"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88086.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626115.1">
        <property type="nucleotide sequence ID" value="XM_626115.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRS1"/>
    <dbReference type="FunCoup" id="Q5CRS1">
        <property type="interactions" value="132"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRS1"/>
    <dbReference type="GeneID" id="3373012"/>
    <dbReference type="KEGG" id="cpv:cgd5_1710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1710"/>
    <dbReference type="InParanoid" id="Q5CRS1"/>
    <dbReference type="OMA" id="EFNNAYR"/>
    <dbReference type="OrthoDB" id="1739076at2759"/>
    <dbReference type="UniPathway" id="UPA00159">
        <property type="reaction ID" value="UER00277"/>
    </dbReference>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003883">
        <property type="term" value="F:CTP synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042802">
        <property type="term" value="F:identical protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016829">
        <property type="term" value="F:lyase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044210">
        <property type="term" value="P:'de novo' CTP biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019856">
        <property type="term" value="P:pyrimidine nucleobase biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03113">
        <property type="entry name" value="CTPS_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd01746">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000009">
        <property type="entry name" value="CTP synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.880">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029062">
        <property type="entry name" value="Class_I_gatase-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004468">
        <property type="entry name" value="CTP_synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017456">
        <property type="entry name" value="CTP_synthase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017926">
        <property type="entry name" value="GATASE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033828">
        <property type="entry name" value="GATase1_CTP_Synthase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003792">
        <property type="entry name" value="PRK05380.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00337">
        <property type="entry name" value="PyrG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550">
        <property type="entry name" value="CTP SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11550:SF0">
        <property type="entry name" value="CTP SYNTHASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06418">
        <property type="entry name" value="CTP_synth_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00117">
        <property type="entry name" value="GATase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52317">
        <property type="entry name" value="Class I glutamine amidotransferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51273">
        <property type="entry name" value="GATASE_TYPE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 11" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 11" id="KW-0315">Glutamine amidotransferase</keyword>
    <keyword evidence="3 11" id="KW-0436">Ligase</keyword>
    <keyword evidence="14" id="KW-0456">Lyase</keyword>
    <keyword evidence="7" id="KW-0460">Magnesium</keyword>
    <keyword evidence="4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="5 11" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9 11" id="KW-0665">Pyrimidine biosynthesis</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CTP synthase N-terminal" evidence="13">
        <location>
            <begin position="32"/>
            <end position="303"/>
        </location>
    </feature>
    <feature type="domain" description="Glutamine amidotransferase" evidence="12">
        <location>
            <begin position="360"/>
            <end position="653"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005171"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007533"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022962"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022975"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047781"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="RuleBase" id="RU810713"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="Pfam" id="PF06418"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAK88086.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="670" mass="74609" checksum="330F262A8B37639D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRU5</accession>
    <name>Q5CRU5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Large protein with signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_1440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88104.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626091.1">
        <property type="nucleotide sequence ID" value="XM_626091.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CRU5"/>
    <dbReference type="GeneID" id="3373283"/>
    <dbReference type="KEGG" id="cpv:cgd5_1440"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_1440"/>
    <dbReference type="InParanoid" id="Q5CRU5"/>
    <dbReference type="OMA" id="WENELNI"/>
    <dbReference type="OrthoDB" id="338862at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253780" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1601"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="702"/>
            <end position="760"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1051"/>
            <end position="1111"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88104.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1601" mass="187255" checksum="F5B8E27C41770583" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS17</accession>
    <name>Q5CS17_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Protein with 4 ankyrin repeats plus a bromodomain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd5_630</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626019.1">
        <property type="nucleotide sequence ID" value="XM_626019.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS17"/>
    <dbReference type="STRING" id="353152.Q5CS17"/>
    <dbReference type="GeneID" id="3373168"/>
    <dbReference type="KEGG" id="cpv:cgd5_630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_630"/>
    <dbReference type="InParanoid" id="Q5CS17"/>
    <dbReference type="OMA" id="CNPNDAD"/>
    <dbReference type="OrthoDB" id="448960at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="CDD" id="cd04369">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.920.10">
        <property type="entry name" value="Bromodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001487">
        <property type="entry name" value="Bromodomain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036427">
        <property type="entry name" value="Bromodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018359">
        <property type="entry name" value="Bromodomain_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050889">
        <property type="entry name" value="Dendritic_Spine_Reg/Scaffold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166:SF48">
        <property type="entry name" value="PROTEIN VAPYRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24166">
        <property type="entry name" value="ROLLING PEBBLES, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00023">
        <property type="entry name" value="Ank"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12796">
        <property type="entry name" value="Ank_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00439">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00503">
        <property type="entry name" value="BROMODOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SMART" id="SM00297">
        <property type="entry name" value="BROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47370">
        <property type="entry name" value="Bromodomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50297">
        <property type="entry name" value="ANK_REP_REGION"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00633">
        <property type="entry name" value="BROMODOMAIN_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50014">
        <property type="entry name" value="BROMODOMAIN_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 4" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="3 5" id="KW-0103">Bromodomain</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="82"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="115"/>
            <end position="147"/>
        </location>
    </feature>
    <feature type="repeat" description="ANK" evidence="4">
        <location>
            <begin position="148"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="Bromo" evidence="6">
        <location>
            <begin position="318"/>
            <end position="390"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00035"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="435" mass="48687" checksum="402D1EEE473C5166" modified="2005-04-12" version="1">MGELVSFESSRLIESIRRDGVQSTLDLIDTLDSSELSKKCSVTNANAIFYAVQRTNDDEALQVCKKILEKCPELDVASTDFSLQTALFFACRDGNVKTAEFLIDNGCNVNHTDRVNQTALFYAARDGRFEAVKLLLDKGAEPNLSDNVGQTALFYAARDGRSQTCMLLLDNGADAGIKDKNRQAAHSYALKSGHKQLANILKNRMASSGGAGMGANAFEGSGNLEKDASLDRVSLCNSIVGEGGIKDSEIRQCYRLQFKGSDGKWYFAPKIKIEEFEEKFPNIAVWSKESPVASLKPNSDPFRASWYKTISECVEELRKQEGAWIFDKPVDEKAWNCSDYYKIITKPMDFSLIRKKLRNGEYELCRETIADIQQIFSNCYLYNKPDSSVSILCKAIEQHFNSLKSSKDIDSILNKEAELFNLKSEVNIKEDTKVE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS21</accession>
    <name>Q5CS21_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88164.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626015.1">
        <property type="nucleotide sequence ID" value="XM_626015.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS21"/>
    <dbReference type="GeneID" id="3373171"/>
    <dbReference type="KEGG" id="cpv:cgd5_580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_580"/>
    <dbReference type="InParanoid" id="Q5CS21"/>
    <dbReference type="OMA" id="VNICTIN"/>
    <dbReference type="OrthoDB" id="343337at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF101447">
        <property type="entry name" value="Formin homology 2 domain (FH2 domain)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="65"/>
            <end position="86"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="236"/>
            <end position="254"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="274"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="304"/>
            <end position="327"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="390"/>
            <end position="422"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="914"/>
            <end position="994"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="390"/>
            <end position="399"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="914"/>
            <end position="926"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="952"/>
            <end position="963"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="966"/>
            <end position="975"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88164.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="994" mass="115705" checksum="9414DF1CEDDF2B44" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS23</accession>
    <name>Q5CS23_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Vacuolar H-ATpase subunit D</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_530</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the V-ATPase D subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626013.1">
        <property type="nucleotide sequence ID" value="XM_626013.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS23"/>
    <dbReference type="FunCoup" id="Q5CS23">
        <property type="interactions" value="195"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CS23"/>
    <dbReference type="GeneID" id="3373310"/>
    <dbReference type="KEGG" id="cpv:cgd5_530"/>
    <dbReference type="InParanoid" id="Q5CS23"/>
    <dbReference type="OMA" id="REEFFRM"/>
    <dbReference type="OrthoDB" id="7676488at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046961">
        <property type="term" value="F:proton-transporting ATPase activity, rotational mechanism"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.3240">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002699">
        <property type="entry name" value="V_ATPase_D"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00309">
        <property type="entry name" value="V_ATPase_subD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11671">
        <property type="entry name" value="V-TYPE ATP SYNTHASE SUBUNIT D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01813">
        <property type="entry name" value="ATP-synt_D"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0406">Ion transport</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="212"/>
            <end position="237"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="212"/>
            <end position="225"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00005850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023065"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="249" mass="28332" checksum="8930A4279B560F0A" modified="2005-04-12" version="1" fragment="single">LLIYRALQAIKLKSKGAKQGYDLLKRKSDALSNKFRGMLKEIVETKRSIGNDIKEASFALAKATWAAGDFKDRIIESCKRPTVTMEVGTENIAGVRLPIFEMNVDNNSSTETCHIGVASGGQVIQSTREIYMKVLRDLVKLASLQTAFFSLDEEIKMTNRRVNALQNVVLPKLEDGMNYILRELDEIEREEFFRLKKIQEKKKEWAEAELQEKLKKDKSNSKENDSSSYDTIKNSGDSILEQKNEGILF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS27</accession>
    <name>Q5CS27_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">GP-PDE domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd5_490</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycerophosphoryl diester phosphodiesterase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88264.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626009.1">
        <property type="nucleotide sequence ID" value="XM_626009.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS27"/>
    <dbReference type="STRING" id="353152.Q5CS27"/>
    <dbReference type="GeneID" id="3373311"/>
    <dbReference type="KEGG" id="cpv:cgd5_490"/>
    <dbReference type="InParanoid" id="Q5CS27"/>
    <dbReference type="OMA" id="KWAIMRK"/>
    <dbReference type="OrthoDB" id="1058301at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008081">
        <property type="term" value="F:phosphoric diester hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046475">
        <property type="term" value="P:glycerophospholipid catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd08612">
        <property type="entry name" value="GDPD_GDE4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.190">
        <property type="entry name" value="Phosphatidylinositol (PI) phosphodiesterase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052271">
        <property type="entry name" value="GDPD-Related"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR030395">
        <property type="entry name" value="GP_PDE_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017946">
        <property type="entry name" value="PLC-like_Pdiesterase_TIM-brl"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42758">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42758:SF2">
        <property type="entry name" value="PHOSPHATIDYLGLYCEROL PHOSPHOLIPASE C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03009">
        <property type="entry name" value="GDPD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51695">
        <property type="entry name" value="PLC-like phosphodiesterases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51704">
        <property type="entry name" value="GP_PDE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="6" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="21"/>
            <end position="39"/>
        </location>
    </feature>
    <feature type="domain" description="GP-PDE" evidence="9">
        <location>
            <begin position="62"/>
            <end position="362"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004370"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007277"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS51704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK88264.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="371" mass="43380" checksum="C19C62B559E0AB65" modified="2005-04-12" version="1" fragment="single">RAKKKKNRNNNNKTIKMVLELFVIILIVNYLLLHFPKILRAINGSNSKLKSSNSVLGKGKGCLHISHRGGSEEVPENTTVAFDHAINNCSTDMLEIDVWLTKDNLLVVLHDENLLNICNIDKLVGEFNYADLPMTKDSESLTPSSDFLNRNEWKCYPKKFSSQKLITLEELFQRYPDTLISVDVKNPDSRLAVSKTVGLVRRFKRENKTMLCSFSNENIDYLNEYNKNKNEPELVICIGKDKLLKILLAYFTGFLPWIHIEEHVLSFPMSYIFFSTYGRKFADKISKYFKLSKYQLKYIEDELVPNILVWLFSRKLLIRHLQKRGIRCFAWVCNNEKEMNICKELELDGIMSDRPNLLREYYIKNKIKPFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS32</accession>
    <name>Q5CS32_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Protein with 2 CAP (CARP) domains, possible adenyl cyclase-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_440</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="5" key="2">
        <citation type="journal article" date="2010" name="J. Biol. Chem." volume="285" first="11572" last="11583">
            <title>Structure and function of a G-actin sequestering protein with a vital role in malaria oocyst development inside the mosquito vector.</title>
            <authorList>
                <person name="Hliscs M."/>
                <person name="Sattler J.M."/>
                <person name="Tempel W."/>
                <person name="Artz J.D."/>
                <person name="Dong A."/>
                <person name="Hui R."/>
                <person name="Matuschewski K."/>
                <person name="Schuler H."/>
            </authorList>
            <dbReference type="PubMed" id="20083609"/>
            <dbReference type="DOI" id="10.1074/jbc.m109.054916"/>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS)</scope>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the CAP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88266.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626004.1">
        <property type="nucleotide sequence ID" value="XM_626004.1"/>
    </dbReference>
    <dbReference type="PDB" id="2B0R">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.60 A"/>
        <property type="chains" value="A/B=1-183"/>
    </dbReference>
    <dbReference type="PDBsum" id="2B0R"/>
    <dbReference type="AlphaFoldDB" id="Q5CS32"/>
    <dbReference type="SMR" id="Q5CS32"/>
    <dbReference type="STRING" id="353152.Q5CS32"/>
    <dbReference type="GeneID" id="3373313"/>
    <dbReference type="KEGG" id="cpv:cgd5_440"/>
    <dbReference type="InParanoid" id="Q5CS32"/>
    <dbReference type="OMA" id="SCKSGDM"/>
    <dbReference type="OrthoDB" id="1601at2759"/>
    <dbReference type="EvolutionaryTrace" id="Q5CS32"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008179">
        <property type="term" value="F:adenylate cyclase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007015">
        <property type="term" value="P:actin filament organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019933">
        <property type="term" value="P:cAMP-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.160.20.70">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001837">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013912">
        <property type="entry name" value="Adenylate_cyclase-assoc_CAP_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017901">
        <property type="entry name" value="C-CAP_CF_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016098">
        <property type="entry name" value="CAP/MinC_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036223">
        <property type="entry name" value="CAP_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006599">
        <property type="entry name" value="CARP_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10652:SF0">
        <property type="entry name" value="ADENYLYL CYCLASE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08603">
        <property type="entry name" value="CAP_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00673">
        <property type="entry name" value="CARP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69340">
        <property type="entry name" value="C-terminal domain of adenylylcyclase associated protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51329">
        <property type="entry name" value="C_CAP_COFACTOR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="5" id="KW-0002">3D-structure</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="C-CAP/cofactor C-like" evidence="2">
        <location>
            <begin position="23"/>
            <end position="159"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="3">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51329"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88266.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="5">
        <source>
            <dbReference type="PDB" id="2B0R"/>
        </source>
    </evidence>
    <sequence length="183" mass="20428" checksum="F371AB78B624EEC5" modified="2005-04-12" version="1" fragment="single">KSQIYLKKEKKMKAARQVVTNGSPKVELQKDTYLVENHVNCADPITLSEGSIKNKVSVRCSQNSRIIVEQKVNSIFIENCVGCIFLVNGVISSIEIVNCDDIKLQMTGIVPTISLDKSNKVNIYTSKEGKNVEVYSSKSSEMNLLFPGEEEGDWKELAIPEQFVTKYNESKGKLESMVSPLYG</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS48</accession>
    <name>Q5CS48_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_260</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88269.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625988.1">
        <property type="nucleotide sequence ID" value="XM_625988.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3373316"/>
    <dbReference type="KEGG" id="cpv:cgd5_260"/>
    <dbReference type="InParanoid" id="Q5CS48"/>
    <dbReference type="OMA" id="TCLINIT"/>
    <dbReference type="OrthoDB" id="433738at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88269.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="825" mass="96672" checksum="50F480623D8535FB" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CS91</accession>
    <name>Q5CS91_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_3640</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88296.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628176.1">
        <property type="nucleotide sequence ID" value="XM_628176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CS91"/>
    <dbReference type="GeneID" id="3371522"/>
    <dbReference type="KEGG" id="cpv:cgd1_3640"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3640"/>
    <dbReference type="InParanoid" id="Q5CS91"/>
    <dbReference type="OMA" id="CRIQSIA"/>
    <dbReference type="OrthoDB" id="337537at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254904" evidence="2">
        <location>
            <begin position="25"/>
            <end position="522"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="66"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="69"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="79"/>
            <end position="89"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88296.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="522" mass="59438" checksum="B83694D74CFE4608" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSA7</accession>
    <name>Q5CSA7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Eukaryotic translation initiation factor 3 subunit M</fullName>
            <shortName evidence="5">eIF3m</shortName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_3480</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.</text>
    </comment>
    <comment type="subunit">
        <text evidence="5">Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="5">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the CSN7/EIF3M family. CSN7 subfamily.</text>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the eIF-3 subunit M family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88307.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628160.1">
        <property type="nucleotide sequence ID" value="XM_628160.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSA7"/>
    <dbReference type="FunCoup" id="Q5CSA7">
        <property type="interactions" value="584"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSA7"/>
    <dbReference type="GeneID" id="3371578"/>
    <dbReference type="KEGG" id="cpv:cgd1_3480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3480"/>
    <dbReference type="InParanoid" id="Q5CSA7"/>
    <dbReference type="OMA" id="VCLKALW"/>
    <dbReference type="OrthoDB" id="10267031at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016282">
        <property type="term" value="C:eukaryotic 43S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033290">
        <property type="term" value="C:eukaryotic 48S preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071541">
        <property type="term" value="C:eukaryotic translation initiation factor 3 complex, eIF3m"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001732">
        <property type="term" value="P:formation of cytoplasmic translation initiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03012">
        <property type="entry name" value="eIF3m"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045237">
        <property type="entry name" value="COPS7/eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027528">
        <property type="entry name" value="eIF3m"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000717">
        <property type="entry name" value="PCI_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350">
        <property type="entry name" value="COP9 SIGNALOSOME COMPLEX SUBUNIT 7/DENDRITIC CELL PROTEIN GA17"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15350:SF2">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT M"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01399">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00088">
        <property type="entry name" value="PINT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50250">
        <property type="entry name" value="PCI"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 5" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="3 5" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="8" id="KW-0647">Proteasome</keyword>
    <keyword evidence="4 5" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PCI" evidence="7">
        <location>
            <begin position="222"/>
            <end position="405"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="437"/>
            <end position="456"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008482"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="HAMAP-Rule" id="MF_03012"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50250"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88307.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="456" mass="52664" checksum="C90BCEBAE4CAE903" modified="2005-04-12" version="1">MMQLVFTSNGNGRSTSILLCDWLFTILDYLDKKKSNSFYEKVCKLVRDDISEVDMASVFELLVENLDGIFEILKDAEVKKEIVIRDDVKRSFGELYKESEEFFIPLISMLLHPKFDKSRIDTCKKIFLEKLMSKGEIPKLRINVLQVYYDIFGQDLELLVNILKYKAQYGCFNNFETMESSLDMLEKKITNIDESKSELKRNLYLGMYDIISSESKDNKNYLNKKAYDYLVGFFETFKSKDEISQSIKSNSRILDLGVQFLISTILLPEILFFDSLLSMPIYQYIKENYSKEYKVLLELFDICYQGTVGDFHDKLQNNNQEYQNFLDKLPILKANESNIVNKLQLLTISTLAKGKSSIKLDELEKEFRLSSFDTQDAVVNAISVGLIDGNISENSNTVNINCVTKRQFGKAEWESLDKKLNQWMGHLTSLSSILANNSNNNNNTNNNNVNNNSNNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSB9</accession>
    <name>Q5CSB9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Haloacid dehalogenase-like hydrolase</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_3340</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88547.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628148.1">
        <property type="nucleotide sequence ID" value="XM_628148.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSB9"/>
    <dbReference type="STRING" id="353152.Q5CSB9"/>
    <dbReference type="DNASU" id="3371447"/>
    <dbReference type="GeneID" id="3371447"/>
    <dbReference type="KEGG" id="cpv:cgd1_3340"/>
    <dbReference type="InParanoid" id="Q5CSB9"/>
    <dbReference type="OMA" id="QVIFQAM"/>
    <dbReference type="OrthoDB" id="27226at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000287">
        <property type="term" value="F:magnesium ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016791">
        <property type="term" value="F:phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1240.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1000">
        <property type="entry name" value="HAD superfamily/HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036412">
        <property type="entry name" value="HAD-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006379">
        <property type="entry name" value="HAD-SF_hydro_IIB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023214">
        <property type="entry name" value="HAD_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01484">
        <property type="entry name" value="HAD-SF-IIB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000:SF8">
        <property type="entry name" value="HAD SUPERFAMILY HYDROLASE-LIKE, TYPE 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10000">
        <property type="entry name" value="PHOSPHOSERINE PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08282">
        <property type="entry name" value="Hydrolase_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDG01140">
        <property type="entry name" value="C2.B:_Phosphomannomutase_and_P"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SFLD" id="SFLDS00003">
        <property type="entry name" value="Haloacid_Dehalogenase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56784">
        <property type="entry name" value="HAD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88547.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="313" mass="34860" checksum="4920830DA2740162" modified="2005-04-12" version="1" fragment="single">EVLYKQIIMESNILCVFTDVDGTLANNENQLSLKNAKTISALMDSHILLVPATGRSKVGFLRMFTEDIMDIAKHHGFPGIFFNGAVLIGPNGIDDIMKTWTISDECMIELCNLLDSIKIEWQPEDEGYEEAKLKGETHRGVAYSVYLLNEFVHNVRGSHLRYVEGLSREFSVKVESVVDVIKKNKNQSLKFIIGESREKLEEIKDIVHAFLKDKPARVLFSHPLILEILHIDCSKGNAAEHLLKTLNIHPENCLAIGDAENDVELLKLSGISVAVANACNMAKGAAQHIVSSNDDDGFSEAIQKFCNIQINLD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSC5</accession>
    <name>Q5CSC5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_3260</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628142.1">
        <property type="nucleotide sequence ID" value="XM_628142.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSC5"/>
    <dbReference type="GeneID" id="3371457"/>
    <dbReference type="KEGG" id="cpv:cgd1_3260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_3260"/>
    <dbReference type="InParanoid" id="Q5CSC5"/>
    <dbReference type="OMA" id="HSEVINH"/>
    <dbReference type="OrthoDB" id="342550at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="334"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="345" mass="40510" checksum="30A66C682EF9D4FF" modified="2005-04-12" version="1">METNIHFDKVCHEGSEIVGDLEQNTMEESLNGNKYTEERNFYDNNSDKHDQNSSLNNHFKQTYEGNSEVIIGNHSIGMEIRTQNEKQDNIEIEKKENNYYTNNNIINVQQQQQLNSKKKASEWRNELLSFPHIFNQVFLSLNRFNDYIDQRWSLLNESHNKLYNLLLELSKTYASINNSVPHNIDNIFFIEKSIHNKYVSLKSKIINHHQLNYFRVTNIYIPGTELNSENIARENEFKMRLYEELYNKFQTCKNDIEITFERKSEMVTQLDSRVNKIVSSIEKFINNNQYLLESHTKPLYNIDSSEICEIGIVKRKTGVRGRPPGSGNRGRPPGSTKKAKKDPQM</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSE5</accession>
    <name>Q5CSE5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Oligosaccharide deacetylase domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_3060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88340.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628122.1">
        <property type="nucleotide sequence ID" value="XM_628122.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSE5"/>
    <dbReference type="STRING" id="353152.Q5CSE5"/>
    <dbReference type="GeneID" id="3371708"/>
    <dbReference type="KEGG" id="cpv:cgd1_3060"/>
    <dbReference type="InParanoid" id="Q5CSE5"/>
    <dbReference type="OMA" id="GWFTTPM"/>
    <dbReference type="OrthoDB" id="337644at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004099">
        <property type="term" value="F:chitin deacetylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005975">
        <property type="term" value="P:carbohydrate metabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.20.20.370">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011330">
        <property type="entry name" value="Glyco_hydro/deAcase_b/a-brl"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002509">
        <property type="entry name" value="NODB_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050248">
        <property type="entry name" value="Polysacc_deacetylase_ArnD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587:SF137">
        <property type="entry name" value="4-DEOXY-4-FORMAMIDO-L-ARABINOSE-PHOSPHOUNDECAPRENOL DEFORMYLASE ARND-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10587">
        <property type="entry name" value="GLYCOSYL TRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01522">
        <property type="entry name" value="Polysacc_deac_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF88713">
        <property type="entry name" value="Glycoside hydrolase/deacetylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51677">
        <property type="entry name" value="NODB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="NodB homology" evidence="2">
        <location>
            <begin position="68"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="212"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS51677"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88340.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="357" mass="40103" checksum="9EA55EC0BD997A8E" modified="2005-04-12" version="1">MNTISSSKSKTGNMFSKTAWEALNKSGTRWAIRTFLRFGRSSFISRSMMNSFGTYLMDAIWWFETEQPIVALTIDDVPGLDPETNENILTLLADYNIKCTFFVTERNAKYIKNADHFLKRCISEGHELGNHLAKDIPAHKLPISVFTKHLLECEHLISKYCPEHISSNSYIIPPMYMNGKKSSSGSQTSTSEMTLSPSSSSSSSSSSSSSSSSMITSTSASTILKTQQTLSDLPEVFYNDGTRNEQLRTYKWFRPPFGRLTKQQYELVVSRGYNVVMCDVYPNDVSFQGFPQFLAQFCTSNASPGSIVCLHIPSNSFRSANIEVLKLMLPELSTKFKCVTLSQLAEQVYREHSSDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSI0</accession>
    <name>Q5CSI0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88513.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628087.1">
        <property type="nucleotide sequence ID" value="XM_628087.1"/>
    </dbReference>
    <dbReference type="GeneID" id="3371413"/>
    <dbReference type="KEGG" id="cpv:cgd1_2610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2610"/>
    <dbReference type="InParanoid" id="Q5CSI0"/>
    <dbReference type="OMA" id="FYIYSTH"/>
    <dbReference type="OrthoDB" id="339680at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="41"/>
            <end position="58"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88513.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2087" mass="245782" checksum="FFF5A862DE38B2E3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSI2</accession>
    <name>Q5CSI2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PGPD14 protein with at least one predicted RING finger, possible plant origin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_2590</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88364.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628085.1">
        <property type="nucleotide sequence ID" value="XM_628085.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSI2"/>
    <dbReference type="STRING" id="353152.Q5CSI2"/>
    <dbReference type="GeneID" id="3371693"/>
    <dbReference type="KEGG" id="cpv:cgd1_2590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2590"/>
    <dbReference type="InParanoid" id="Q5CSI2"/>
    <dbReference type="OMA" id="KLYPCRL"/>
    <dbReference type="OrthoDB" id="411372at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016567">
        <property type="term" value="P:protein ubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.28.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039512">
        <property type="entry name" value="RCHY1_zinc-ribbon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027370">
        <property type="entry name" value="Znf-RING_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008913">
        <property type="entry name" value="Znf_CHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037274">
        <property type="entry name" value="Znf_CHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017921">
        <property type="entry name" value="Znf_CTCHY"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037275">
        <property type="entry name" value="Znf_CTCHY_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21319:SF53">
        <property type="entry name" value="RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05495">
        <property type="entry name" value="zf-CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13445">
        <property type="entry name" value="zf-RING_UBOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF14599">
        <property type="entry name" value="zinc_ribbon_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161219">
        <property type="entry name" value="CHY zinc finger-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF161245">
        <property type="entry name" value="Zinc hairpin stack"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51266">
        <property type="entry name" value="ZF_CHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51270">
        <property type="entry name" value="ZF_CTCHY"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CHY-type" evidence="6">
        <location>
            <begin position="1"/>
            <end position="69"/>
        </location>
    </feature>
    <feature type="domain" description="CTCHY-type" evidence="7">
        <location>
            <begin position="80"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="5">
        <location>
            <begin position="146"/>
            <end position="192"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00601"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51266"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51270"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88364.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="256" mass="29238" checksum="F076ED8E76747CB2" modified="2005-04-12" version="1">MDGCKHYKSRCRIIAPCCNNEYWCRHCHNESQEDHHEVDRFSIKEVVCRRCNKRQPASNSCINSAECGEKSGKKCDVTQFAKYFCSKCNLWDDNGIEKNVFHCDECGICRVGGQESYFHCKVCCMCYPLSIKETHKCIENSCRRPCPLCLEDLFYSIKTVSILNCGHTIHEDCLLLLGEAKGLTSLRCPICSKSLGDNSQIWNEIDKMIAESPIPEESKELVNIFCNDCNIKCNTYSHPYGLKCQTCGGYNTRLED</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="50" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSL1</accession>
    <name>Q5CSL1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apicomplexan specific protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88384.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628056.1">
        <property type="nucleotide sequence ID" value="XM_628056.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSL1"/>
    <dbReference type="FunCoup" id="Q5CSL1">
        <property type="interactions" value="2"/>
    </dbReference>
    <dbReference type="GeneID" id="3371674"/>
    <dbReference type="KEGG" id="cpv:cgd1_2220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2220"/>
    <dbReference type="InParanoid" id="Q5CSL1"/>
    <dbReference type="OMA" id="QLCINCS"/>
    <dbReference type="OrthoDB" id="361877at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014876">
        <property type="entry name" value="DEK_C"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08766">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF109715">
        <property type="entry name" value="DEK C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51998">
        <property type="entry name" value="DEK_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DEK-C" evidence="1">
        <location>
            <begin position="13"/>
            <end position="71"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS51998"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88384.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="213" mass="23777" checksum="E765337FEE2516D3" modified="2005-04-12" version="1">METNPEESNQLVNTSAEVIRTYLNKIVTNDNLDTLTPKKVREELEKALGLPLDSLKPKKNQINDLIDAIILEIKEKNSTDSPIEQITNNVSNVDYKDEETNANNDEEHNDLNINIPEITKQNGKATKRKQISMSIEEFLEKSQTLSLSINGSSEKLAISPRQFSTGSVGWYYGGKVPLPVGDDLEVLCQISINCTVVGSKTWSQNISKKSKIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSR4</accession>
    <name>Q5CSR4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_1630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88432.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628003.1">
        <property type="nucleotide sequence ID" value="XM_628003.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSR4"/>
    <dbReference type="GeneID" id="3371644"/>
    <dbReference type="KEGG" id="cpv:cgd1_1630"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1630"/>
    <dbReference type="InParanoid" id="Q5CSR4"/>
    <dbReference type="OrthoDB" id="343667at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88432.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="165" mass="18906" checksum="D7F77BE829F7BE14" modified="2005-04-12" version="1">MSSNIIGIGRTSMMKREIRWADIEEDDHVFLNEDNLPNKTSVEQQLEQLNELESDHFLEIESSNIFLPLIKGKCSRAARRQQKLNALDDDIDEILKEFGLGDSLRKIEEVEEIVNNGCNNSIGCKSYQNKVSKEFIAESTARALGEIKSRNKKQKKKSSANNHYY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSR9</accession>
    <name>Q5CSR9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">RING finger domain at N-terminus, CCCH domain at C-terminus, involved in RNA metabolism, HC-23 protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_1580</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88574.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627998.1">
        <property type="nucleotide sequence ID" value="XM_627998.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSR9"/>
    <dbReference type="GeneID" id="3371362"/>
    <dbReference type="KEGG" id="cpv:cgd1_1580"/>
    <dbReference type="InParanoid" id="Q5CSR9"/>
    <dbReference type="OMA" id="LEADCKF"/>
    <dbReference type="OrthoDB" id="410307at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1000.10">
        <property type="entry name" value="Zinc finger, CCCH-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000571">
        <property type="entry name" value="Znf_CCCH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036855">
        <property type="entry name" value="Znf_CCCH_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00642">
        <property type="entry name" value="zf-CCCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00356">
        <property type="entry name" value="ZnF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90229">
        <property type="entry name" value="CCCH zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50103">
        <property type="entry name" value="ZF_C3H1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 4" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="26"/>
            <end position="71"/>
        </location>
    </feature>
    <feature type="domain" description="C3H1-type" evidence="7">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="zinc finger region" description="C3H1-type" evidence="4">
        <location>
            <begin position="770"/>
            <end position="797"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="471"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="585"/>
            <end position="650"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="710"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="806"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="862"/>
            <end position="897"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="479"/>
            <end position="492"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="587"/>
            <end position="649"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="713"/>
            <end position="753"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="819"/>
            <end position="841"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="862"/>
            <end position="878"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="879"/>
            <end position="890"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50103"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88574.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="935" mass="99061" checksum="2921BE57C4E6DA17" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSU5</accession>
    <name>Q5CSU5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Domain KOG1676, K-homology type RNA binding proteins</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_1280</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88458.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627972.1">
        <property type="nucleotide sequence ID" value="XM_627972.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSU5"/>
    <dbReference type="STRING" id="353152.Q5CSU5"/>
    <dbReference type="GeneID" id="3371592"/>
    <dbReference type="KEGG" id="cpv:cgd1_1280"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1280"/>
    <dbReference type="InParanoid" id="Q5CSU5"/>
    <dbReference type="OMA" id="ERARCWD"/>
    <dbReference type="OrthoDB" id="5204190at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd00105">
        <property type="entry name" value="KH-I"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1370.10">
        <property type="entry name" value="K Homology domain, type 1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004087">
        <property type="entry name" value="KH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004088">
        <property type="entry name" value="KH_dom_type_1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036612">
        <property type="entry name" value="KH_dom_type_1_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10288">
        <property type="entry name" value="KH DOMAIN CONTAINING RNA BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00013">
        <property type="entry name" value="KH_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00322">
        <property type="entry name" value="KH"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54791">
        <property type="entry name" value="Eukaryotic type KH-domain (KH-domain type I)"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50084">
        <property type="entry name" value="KH_TYPE_1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="8"/>
            <end position="76"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="91"/>
            <end position="180"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="201"/>
            <end position="264"/>
        </location>
    </feature>
    <feature type="domain" description="K Homology" evidence="4">
        <location>
            <begin position="277"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="131"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="421"/>
            <end position="440"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="137"/>
            <end position="150"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="428"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00117"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88458.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="460" mass="50330" checksum="69508BB838C2236D" modified="2005-04-12" version="1">MLNILKVGDNQTIAQIESADASFIVGTGGRTRRKLAAVSGTSITIIQDDSKTARVEINGDAACREKAYLYLKYLVQQKHGPVTIDVTPDSRDDLTIVNVPALCVGYITGKKGQGLRAIEEDSGTLMFFSRPEEECPTDSTPPSNGVPMNNGNSQSQYILAIFGVARNRRAAELRVMCYIEQKINGHFTKDLKAESHDHIEDLATDIVHIETEDLSYAVGKEGNTRRRLCASSGAIIEYVGNFAFIHGDLSERKRAKEYLAWLIAQRTSTVSVDTRAREDVTVVSIPQNVIGYVTGAKGSFLRRVEDETGTFIFIDENKGNVLERVLIFSRSAFGRQKARDFIERRMYEKLCGYADNKNYPQNGNGFNGRNMNGIRKTNGITLNNSHFDHPMKGNFAAIPNAFLSQPGISGLGAPNMGIGRRSRTRGGAPEHHISDKSSGKPAGLYGGNLVPFGLSGGALF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSW2</accession>
    <name>Q5CSW2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Alpha beta hydrolase with 5 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd1_1100</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="4" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="4">Iowa type II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88473.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627955.1">
        <property type="nucleotide sequence ID" value="XM_627955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSW2"/>
    <dbReference type="STRING" id="353152.Q5CSW2"/>
    <dbReference type="ESTHER" id="crypv-q5csw2">
        <property type="family name" value="Cocaine_esterase"/>
    </dbReference>
    <dbReference type="GeneID" id="3371607"/>
    <dbReference type="KEGG" id="cpv:cgd1_1100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1100"/>
    <dbReference type="InParanoid" id="Q5CSW2"/>
    <dbReference type="OMA" id="IWHAGER"/>
    <dbReference type="OrthoDB" id="416441at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008239">
        <property type="term" value="F:dipeptidyl-peptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1820">
        <property type="entry name" value="alpha/beta hydrolase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.120.260">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029058">
        <property type="entry name" value="AB_hydrolase_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005674">
        <property type="entry name" value="CocE/Ser_esterase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008979">
        <property type="entry name" value="Galactose-bd-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000383">
        <property type="entry name" value="Xaa-Pro-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013736">
        <property type="entry name" value="Xaa-Pro_dipept_C"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00976">
        <property type="entry name" value="CocE_NonD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02129">
        <property type="entry name" value="Peptidase_S15"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08530">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00939">
        <property type="entry name" value="PepX_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53474">
        <property type="entry name" value="alpha/beta-Hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49785">
        <property type="entry name" value="Galactose-binding domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 4" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="129"/>
            <end position="148"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="181"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="230"/>
            <end position="257"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="291"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="322"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="Xaa-Pro dipeptidyl-peptidase C-terminal" evidence="3">
        <location>
            <begin position="777"/>
            <end position="1084"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00939"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88473.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1103" mass="125962" checksum="BFD7187C164A1CD3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTG4</accession>
    <name>Q5CTG4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Macro domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_3110</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88703.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626505.1">
        <property type="nucleotide sequence ID" value="XM_626505.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTG4"/>
    <dbReference type="GeneID" id="3373563"/>
    <dbReference type="KEGG" id="cpv:cgd2_3110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_3110"/>
    <dbReference type="InParanoid" id="Q5CTG4"/>
    <dbReference type="OMA" id="SCECIVI"/>
    <dbReference type="OrthoDB" id="343649at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253826" description="Macro domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="1040"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="213"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="466"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="791"/>
            <end position="829"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="221"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="474"/>
            <end position="501"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="509"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="800"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="820"/>
            <end position="829"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88703.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="1040" mass="115034" checksum="5B3D258431DBB54C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTP1</accession>
    <name>Q5CTP1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_2230</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the sestrin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88772.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626428.1">
        <property type="nucleotide sequence ID" value="XM_626428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTP1"/>
    <dbReference type="STRING" id="353152.Q5CTP1"/>
    <dbReference type="GeneID" id="3373516"/>
    <dbReference type="KEGG" id="cpv:cgd2_2230"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2230"/>
    <dbReference type="InParanoid" id="Q5CTP1"/>
    <dbReference type="OMA" id="INTANSH"/>
    <dbReference type="OrthoDB" id="337464at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070728">
        <property type="term" value="F:L-leucine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016684">
        <property type="term" value="F:oxidoreductase activity, acting on peroxide as acceptor"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071233">
        <property type="term" value="P:cellular response to L-leucine"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990253">
        <property type="term" value="P:cellular response to leucine starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904262">
        <property type="term" value="P:negative regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016239">
        <property type="term" value="P:positive regulation of macroautophagy"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1901031">
        <property type="term" value="P:regulation of response to reactive oxygen species"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029032">
        <property type="entry name" value="AhpD-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006730">
        <property type="entry name" value="Sestrin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474">
        <property type="entry name" value="P53 REGULATED PA26 NUCLEAR PROTEIN SESTRIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12474:SF0">
        <property type="entry name" value="SESTRIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04636">
        <property type="entry name" value="PA26"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69118">
        <property type="entry name" value="AhpD-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008350"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88772.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="833" mass="96826" checksum="209DCBB4DC9743E3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTX9</accession>
    <name>Q5CTX9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1130</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88846.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626340.1">
        <property type="nucleotide sequence ID" value="XM_626340.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTX9"/>
    <dbReference type="GeneID" id="3373589"/>
    <dbReference type="KEGG" id="cpv:cgd2_1130"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1130"/>
    <dbReference type="InParanoid" id="Q5CTX9"/>
    <dbReference type="OrthoDB" id="341471at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88846.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="681" mass="79691" checksum="048432338959C3F8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTY3</accession>
    <name>Q5CTY3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1080</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88849.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626336.1">
        <property type="nucleotide sequence ID" value="XM_626336.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTY3"/>
    <dbReference type="GeneID" id="3373592"/>
    <dbReference type="KEGG" id="cpv:cgd2_1080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_1080"/>
    <dbReference type="InParanoid" id="Q5CTY3"/>
    <dbReference type="OMA" id="STICCNE"/>
    <dbReference type="OrthoDB" id="337892at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88849.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="584" mass="69124" checksum="7ABB1850FE064192" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU59</accession>
    <name>Q5CU59_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_4110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK88958.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626955.1">
        <property type="nucleotide sequence ID" value="XM_626955.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU59"/>
    <dbReference type="GeneID" id="3373896"/>
    <dbReference type="KEGG" id="cpv:cgd3_4110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_4110"/>
    <dbReference type="InParanoid" id="Q5CU59"/>
    <dbReference type="OMA" id="NENINHR"/>
    <dbReference type="OrthoDB" id="337589at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88958.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="699" mass="81540" checksum="9BA590170CA478FE" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="65" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUC3</accession>
    <name>Q5CUC3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">Replication factor A protein 3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_3400</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the replication factor A protein 3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89254.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626891.1">
        <property type="nucleotide sequence ID" value="XM_626891.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUC3"/>
    <dbReference type="FunCoup" id="Q5CUC3">
        <property type="interactions" value="56"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUC3"/>
    <dbReference type="GeneID" id="3373939"/>
    <dbReference type="KEGG" id="cpv:cgd3_3400"/>
    <dbReference type="InParanoid" id="Q5CUC3"/>
    <dbReference type="OMA" id="IAPRVNK"/>
    <dbReference type="OrthoDB" id="188186at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031981">
        <property type="term" value="C:nuclear lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006260">
        <property type="term" value="P:DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04479">
        <property type="entry name" value="RPA3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013970">
        <property type="entry name" value="Rfa2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08661">
        <property type="entry name" value="Rep_fac-A_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50249">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0539">Nucleus</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89254.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="6">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="110" mass="12418" checksum="5E3F1A92E09D5637" modified="2005-04-12" version="1" fragment="single">HLTNRRVNKEELQNFVNKQVRFVGKVVSVEGEIVILEAPDGGTVRCRTISPPPSTYVEVIAQVMPDLSLTQTDFMFDLGDSLNMDLVNESIKVSFHPKLRQHWEPVSNIA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUF0</accession>
    <name>Q5CUF0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">12 transmembrane domain protein MFS family sugar transporter</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd3_3100</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="6">Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89024.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626864.1">
        <property type="nucleotide sequence ID" value="XM_626864.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUF0"/>
    <dbReference type="FunCoup" id="Q5CUF0">
        <property type="interactions" value="5"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUF0"/>
    <dbReference type="GeneID" id="3373884"/>
    <dbReference type="KEGG" id="cpv:cgd3_3100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_3100"/>
    <dbReference type="InParanoid" id="Q5CUF0"/>
    <dbReference type="OMA" id="NSPNWFA"/>
    <dbReference type="OrthoDB" id="440755at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0022857">
        <property type="term" value="F:transmembrane transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1250.20">
        <property type="entry name" value="MFS general substrate transporter like domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011701">
        <property type="entry name" value="MFS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020846">
        <property type="entry name" value="MFS_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044770">
        <property type="entry name" value="MFS_spinster-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036259">
        <property type="entry name" value="MFS_trans_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505:SF52">
        <property type="entry name" value="MAJOR FACILITATOR SUPERFAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23505">
        <property type="entry name" value="SPINSTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07690">
        <property type="entry name" value="MFS_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103473">
        <property type="entry name" value="MFS general substrate transporter"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50850">
        <property type="entry name" value="MFS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0762">Sugar transport</keyword>
    <keyword evidence="3 7 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="105"/>
            <end position="127"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="134"/>
            <end position="152"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="164"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="194"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="228"/>
            <end position="248"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="357"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="396"/>
            <end position="420"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="432"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="458"/>
            <end position="484"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="496"/>
            <end position="519"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="547"/>
            <end position="570"/>
        </location>
    </feature>
    <feature type="domain" description="Major facilitator superfamily (MFS) profile" evidence="8">
        <location>
            <begin position="69"/>
            <end position="562"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00024338"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89024.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="611" mass="66723" checksum="3F2CACA7BB9AC0FB" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUL0</accession>
    <name>Q5CUL0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">RING-type E3 ubiquitin transferase</fullName>
            <ecNumber evidence="6">2.3.2.27</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd3_2410</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 15">
            <text>S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.</text>
            <dbReference type="EC" id="2.3.2.27"/>
        </reaction>
    </comment>
    <comment type="pathway">
        <text evidence="4">Protein modification; protein ubiquitination.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="3">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the ubiquitin conjugation factor E4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.2.27" evidence="6"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89077.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626804.1">
        <property type="nucleotide sequence ID" value="XM_626804.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUL0"/>
    <dbReference type="STRING" id="353152.Q5CUL0"/>
    <dbReference type="GeneID" id="3373917"/>
    <dbReference type="KEGG" id="cpv:cgd3_2410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2410"/>
    <dbReference type="InParanoid" id="Q5CUL0"/>
    <dbReference type="OMA" id="YMNIHTW"/>
    <dbReference type="OrthoDB" id="20295at2759"/>
    <dbReference type="UniPathway" id="UPA00143"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000151">
        <property type="term" value="C:ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034450">
        <property type="term" value="F:ubiquitin-ubiquitin ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0036503">
        <property type="term" value="P:ERAD pathway"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000209">
        <property type="term" value="P:protein polyubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006511">
        <property type="term" value="P:ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.40.10:FF:000055">
        <property type="entry name" value="Ubiquitin conjugation factor e4 a"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019474">
        <property type="entry name" value="Ub_conjug_fac_E4_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045132">
        <property type="entry name" value="UBE4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003613">
        <property type="entry name" value="Ubox_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931:SF2">
        <property type="entry name" value="UBIQUITIN CONJUGATION FACTOR E4 B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13931">
        <property type="entry name" value="UBIQUITINATION FACTOR E4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04564">
        <property type="entry name" value="U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10408">
        <property type="entry name" value="Ufd2P_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00504">
        <property type="entry name" value="Ubox"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51698">
        <property type="entry name" value="U_BOX"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0808">Transferase</keyword>
    <keyword evidence="9" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="domain" description="U-box" evidence="12">
        <location>
            <begin position="967"/>
            <end position="1041"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="11">
        <location>
            <begin position="764"/>
            <end position="789"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="11">
        <location>
            <begin position="764"/>
            <end position="781"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00004906"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00007434"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00012483"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="PROSITE" id="PS51698"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK89077.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1041" mass="120344" checksum="B203B4EA52F0D93B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUN2</accession>
    <name>Q5CUN2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_2140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89091.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626782.1">
        <property type="nucleotide sequence ID" value="XM_626782.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUN2"/>
    <dbReference type="GeneID" id="3374040"/>
    <dbReference type="KEGG" id="cpv:cgd3_2140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2140"/>
    <dbReference type="InParanoid" id="Q5CUN2"/>
    <dbReference type="OrthoDB" id="341527at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="228"/>
            <end position="255"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89091.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="443" mass="52289" checksum="5332E1606883598C" modified="2005-04-12" version="1">MHERTDLFFPVSTNVDLTISRCKKKLASLRRYIKSVSYLKSQTDTGHSRDKYDFNIRNNMRQLELNKNEKCMDLRRNDEKKWNYKYYGQNEKKYNAEMNTCSGIDSESSISYNSSFVNKLIERYYSTSKSKLPDLNNVEKIISFQTTSNLSTPQLRRNNERKDESQINQNIPKNNIELNNFESNYGSNCNPKLDSDYKNNNRKENFEKQESPHATLLKQYDLETREIVDNLDKKIRNLERRLKKDKRKIKLHNKNEFQEPIYERLERSNSMESKLLSISVMPPNGISCFESSFLPYYCTQQEIKIVEDLISIKGEIYGSSQTSIKVVGIGKIFCCHARTRFIDSIKRLYQGSINFIKLKLLIYIEEPEILLANTCGPQTFENKYDMNFYEFEELYETKKISRFLICLVITDRPMECFKKRCYTISNAKQVLPIYIININSISS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUT6</accession>
    <name>Q5CUT6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Large protein with signal peptide. cysteine-rich, threonine-rich, possible mucin</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_1540</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89135.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626728.1">
        <property type="nucleotide sequence ID" value="XM_626728.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CUT6"/>
    <dbReference type="STRING" id="353152.Q5CUT6"/>
    <dbReference type="GeneID" id="3374025"/>
    <dbReference type="KEGG" id="cpv:cgd3_1540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1540"/>
    <dbReference type="InParanoid" id="Q5CUT6"/>
    <dbReference type="OMA" id="HSEREYN"/>
    <dbReference type="OrthoDB" id="338874at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254531" evidence="3">
        <location>
            <begin position="21"/>
            <end position="1616"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="876"/>
            <end position="923"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1386"/>
            <end position="1429"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1297"/>
            <end position="1342"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="894"/>
            <end position="917"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1391"/>
            <end position="1429"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89135.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1616" mass="184649" checksum="41D36B30FE04906B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUX6</accession>
    <name>Q5CUX6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1100</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89166.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626688.1">
        <property type="nucleotide sequence ID" value="XM_626688.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUX6"/>
    <dbReference type="STRING" id="353152.Q5CUX6"/>
    <dbReference type="GeneID" id="3374170"/>
    <dbReference type="KEGG" id="cpv:cgd3_1100"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1100"/>
    <dbReference type="InParanoid" id="Q5CUX6"/>
    <dbReference type="OMA" id="FHFYESK"/>
    <dbReference type="OrthoDB" id="341740at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="140"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="207"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="145"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="208"/>
            <end position="226"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89166.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="463" mass="55520" checksum="75DED6F39C24618D" modified="2005-04-12" version="1">MKSNKYQEFESLPNSLLFEKKSKSQVLRQNDLITNIVRDNLDNGNKLFNDEHDVNNFDDLPFVIPSKRIIIEWPLHLLKNLKALDFENNDFSKYELENIEICKIVSNNVREKGAQEWEQAQKCEEEPVQEQKKELIQELEEEPVQEQKKEPVQEYNKEPIQEQKKELIQELEEEPIQEYNKEPVQEQKKELVQEHNKEELFQEHELEQTQNRNRNQNQNQSQKQQLTIQKQLNIQKPQLNVQKHQLEQTKFPTNLRLKYMQIYIMGGYAKKHFHNKEQNSYNIRVEIKKNQEIQAIKVINILEKDDMHFFHHGNNILSSFQSNNSEYHRKFISSQIQANKRMFRLNSHQYKLQIFKFLNIKIPIKCDDQIYLYLGNSQSKHEFNDVQKDHQIHRRNAILPITKQNLLKLTKDGGFQTLLELHDHFYTFQTNITQQNSTHSFLSQNFNHPDTFIGYILLSIQKA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV03</accession>
    <name>Q5CV03_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_790</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89187.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626661.1">
        <property type="nucleotide sequence ID" value="XM_626661.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV03"/>
    <dbReference type="GeneID" id="3374133"/>
    <dbReference type="KEGG" id="cpv:cgd3_790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_790"/>
    <dbReference type="InParanoid" id="Q5CV03"/>
    <dbReference type="OMA" id="DISLWIC"/>
    <dbReference type="OrthoDB" id="339103at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89187.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="536" mass="61826" checksum="4DDD79F61D1402D0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVF3</accession>
    <name>Q5CVF3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Conserved protein, methylase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_4270</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the methyltransferase superfamily. METL family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89731.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627316.1">
        <property type="nucleotide sequence ID" value="XM_627316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVF3"/>
    <dbReference type="FunCoup" id="Q5CVF3">
        <property type="interactions" value="401"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVF3"/>
    <dbReference type="GeneID" id="3374630"/>
    <dbReference type="KEGG" id="cpv:cgd8_4270"/>
    <dbReference type="InParanoid" id="Q5CVF3"/>
    <dbReference type="OMA" id="PAKYWDI"/>
    <dbReference type="OrthoDB" id="417697at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008173">
        <property type="term" value="F:RNA methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008757">
        <property type="term" value="F:S-adenosylmethionine-dependent methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032259">
        <property type="term" value="P:methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026113">
        <property type="entry name" value="METTL2/6/8-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809">
        <property type="entry name" value="METHYLTRANSFERASE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22809:SF5">
        <property type="entry name" value="TRNA N(3)-METHYLCYTIDINE METHYLTRANSFERASE METTL6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13489">
        <property type="entry name" value="Methyltransf_23"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF037755">
        <property type="entry name" value="Mettl2_prd"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 4" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89731.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="276" mass="32474" checksum="3433C4742057EA1A" modified="2005-04-12" version="1" fragment="single">YWFNFLIDKYIKESVKNWDKFYKRNNINFFLDRHWIDKEFKELISNSTNISDDMNPKVLIEFGCGVGNSLIPLLQISKDLHCIGFDCSSRAISLFEERWNKILANLENNENNEKNSKICPFNCLKDSDKPCTRFRGFVFDIVHSDIPTYICPESFADFGLLIFVLSAIHPKHHQDVITRCSKSLKSGATLLFRDYGRYDMAQLRFAKSSKSKITDNFYVRYDGTFAYYFTIEEIENLFVNAGFKVISNHYCLREVVNRKTQVTMQRVWIQAKFTKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVI0</accession>
    <name>Q5CVI0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_3980</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627289.1">
        <property type="nucleotide sequence ID" value="XM_627289.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVI0"/>
    <dbReference type="GeneID" id="3374592"/>
    <dbReference type="KEGG" id="cpv:cgd8_3980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3980"/>
    <dbReference type="InParanoid" id="Q5CVI0"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="267" mass="30645" checksum="409D098B4C0D4EA7" modified="2005-04-12" version="1">MASLNDISKGSQGSQLIDLNGSEKRNDYMDYMSHLQSSAAQLRYENSVLKNDNANLVSKLDRAVSKSRNGVEIPENATTAEIAEAFEKLNDENCRLKREMERLIRSNTRYRVAMQNRDPSLIPSEEQDKSFFNSDDSGGRLCQCEYILNEILEAVSYKLETYEKHIWEHRLATLTSERDEIAVQNISLVDRLAEIEAIIKVDHVLAERFNVPLEGCDEKNQILTLHRKLGFALDVNQQLERRLAFETQLSRSWQSNMHTIVSEVSFS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="93" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVK5</accession>
    <name>Q5CVK5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">D441/Mpe1p like protein with a zinc knuckle (C2HC) and PhD Zn finger domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_3720</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89530.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627264.1">
        <property type="nucleotide sequence ID" value="XM_627264.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVK5"/>
    <dbReference type="STRING" id="353152.Q5CVK5"/>
    <dbReference type="GeneID" id="3374279"/>
    <dbReference type="KEGG" id="cpv:cgd8_3720"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3720"/>
    <dbReference type="InParanoid" id="Q5CVK5"/>
    <dbReference type="OMA" id="VSPDYIC"/>
    <dbReference type="OrthoDB" id="106784at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003697">
        <property type="term" value="F:single-stranded DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0061630">
        <property type="term" value="F:ubiquitin protein ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006301">
        <property type="term" value="P:DNA damage tolerance"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006513">
        <property type="term" value="P:protein monoubiquitination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16620">
        <property type="entry name" value="vRING-HC-C4C4_RBBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.60.10">
        <property type="entry name" value="Zinc finger, CCHC-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039577">
        <property type="entry name" value="Rad18"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025829">
        <property type="entry name" value="Zn_knuckle_CX2CX3GHX4C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001878">
        <property type="entry name" value="Znf_CCHC"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036875">
        <property type="entry name" value="Znf_CCHC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE RAD18"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14134:SF3">
        <property type="entry name" value="RING-CH-TYPE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13696">
        <property type="entry name" value="zf-CCHC_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57756">
        <property type="entry name" value="Retrovirus zinc finger-like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50158">
        <property type="entry name" value="ZF_CCHC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="CCHC-type" evidence="7">
        <location>
            <begin position="294"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="domain" description="RING-type" evidence="6">
        <location>
            <begin position="396"/>
            <end position="448"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="94"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="207"/>
            <end position="230"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="100"/>
            <end position="119"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="120"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="157"/>
            <end position="169"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="209"/>
            <end position="230"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00047"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50158"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89530.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="475" mass="51932" checksum="D46EC5513F09891F" modified="2005-04-12" version="1">MANNKIYYKFKSEKKFKDLTHEFPALVSHVRSKLREILDIGEDMDILATQSDKNGRVSNVYLSDYEILKEGIYLNVVRLPKDLAKPLLEAANSKIKSKPSTVSQATNSASSSTAPSNISMREQTILSPPSTTDLAPNSGNFTKVGESKDDDHNSVLNSTNPSNNSKNSSSEDAAILLVMQQHGEKFKQTAAQRSEMLEQFNQRGYPKSVTATGSRYGAGNTTGTNFSASSQFRSEPYKKLGAIGTGPLNTGSSNNYFGGQSYNANFGPSSVSANYNYKNAMANTSTDVPADYICHMCGERGHHIRVCPKVNEGVSQKKIRPATGIPRSFLRAINFDEEGRLYSEVYCLPDGTFAVLKDAKQLSSTAFLTRTVEDTIGKHMGKSKEDTSLVRDSLTCPICARLFRYAVLTPCCGETYCQECIINFIRNHMDAASGISPNTIKGYCPHCSTVISIADLEPNNPIRKSVNVALGLQPI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="66" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVT0</accession>
    <name>Q5CVT0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">SUI1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd8_2890</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the DENR family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89470.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627189.1">
        <property type="nucleotide sequence ID" value="XM_627189.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVT0"/>
    <dbReference type="FunCoup" id="Q5CVT0">
        <property type="interactions" value="487"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVT0"/>
    <dbReference type="GeneID" id="3374323"/>
    <dbReference type="KEGG" id="cpv:cgd8_2890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2890"/>
    <dbReference type="InParanoid" id="Q5CVT0"/>
    <dbReference type="OMA" id="EVFEIDM"/>
    <dbReference type="OrthoDB" id="277199at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0001731">
        <property type="term" value="P:formation of translation preinitiation complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002188">
        <property type="term" value="P:translation reinitiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd11607">
        <property type="entry name" value="DENR_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.780.10">
        <property type="entry name" value="SUI1-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050318">
        <property type="entry name" value="DENR/SUI1_TIF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR046447">
        <property type="entry name" value="DENR_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001950">
        <property type="entry name" value="SUI1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036877">
        <property type="entry name" value="SUI1_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789:SF0">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12789">
        <property type="entry name" value="DENSITY-REGULATED PROTEIN HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01253">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55159">
        <property type="entry name" value="eIF1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50296">
        <property type="entry name" value="SUI1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="SUI1" evidence="3">
        <location>
            <begin position="90"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="65"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007514"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50296"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89470.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="174" mass="19437" checksum="310D1AE9F8CB3F9C" modified="2005-04-12" version="1">MEIKTREVIKEIQTIEYCKSCGLPTDYCEYGQCTKNKILGHNEVSEANKLDSQLNTSLKIDETQISQGSAQKKHEESNSAKKKKTKQNVITIKVESRARRKNVTVVNGLELFDIQLSEAAKKFAKQFSCGASVVKGTSGKPDHIDVQGDFDITIAEFILKIYPNIEPSNIVIQT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="104" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVU2</accession>
    <name>Q5CVU2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">SNF2L ortholog with a SWI/SNF2 like ATpase and a Myb domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_2770</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89461.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627177.1">
        <property type="nucleotide sequence ID" value="XM_627177.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CVU2"/>
    <dbReference type="GeneID" id="3374339"/>
    <dbReference type="KEGG" id="cpv:cgd8_2770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2770"/>
    <dbReference type="InParanoid" id="Q5CVU2"/>
    <dbReference type="OMA" id="INIPCAR"/>
    <dbReference type="OrthoDB" id="5857104at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140658">
        <property type="term" value="F:ATP-dependent chromatin remodeler activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042393">
        <property type="term" value="F:histone binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034728">
        <property type="term" value="P:nucleosome organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd18793">
        <property type="entry name" value="SF2_C_SNF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000082">
        <property type="entry name" value="ISWI chromatin remodeling complex ATPase ISW1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10810">
        <property type="entry name" value="Tandem AAA-ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017884">
        <property type="entry name" value="SANT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038718">
        <property type="entry name" value="SNF2-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049730">
        <property type="entry name" value="SNF2/RAD54-like_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000330">
        <property type="entry name" value="SNF2_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623">
        <property type="entry name" value="CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45623:SF49">
        <property type="entry name" value="SWI_SNF-RELATED MATRIX-ASSOCIATED ACTIN-DEPENDENT REGULATOR OF CHROMATIN SUBFAMILY A MEMBER 5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00176">
        <property type="entry name" value="SNF2-rel_dom"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51293">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="176"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="519"/>
            <end position="670"/>
        </location>
    </feature>
    <feature type="domain" description="SANT" evidence="8">
        <location>
            <begin position="991"/>
            <end position="1042"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="742"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1189"/>
            <end position="1308"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="747"/>
            <end position="765"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="1212"/>
            <end position="1222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="5">
        <location>
            <begin position="1231"/>
            <end position="1280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="1285"/>
            <end position="1308"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009687"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS51293"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89461.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1308" mass="151539" checksum="7AF2B01D2BB07665" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="102" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVY3</accession>
    <name>Q5CVY3_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">proton-translocating NAD(P)(+) transhydrogenase</fullName>
            <ecNumber evidence="2">7.1.1.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="18" type="ORF">cgd8_2330</name>
    </gene>
    <organism evidence="18 19">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="18 19" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="19">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="12">
            <text>NAD(+) + NADPH + H(+)(in) = NADH + NADP(+) + H(+)(out)</text>
            <dbReference type="Rhea" id="RHEA:47992"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57540"/>
            <dbReference type="ChEBI" id="CHEBI:57783"/>
            <dbReference type="ChEBI" id="CHEBI:57945"/>
            <dbReference type="ChEBI" id="CHEBI:58349"/>
            <dbReference type="EC" id="7.1.1.1"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell inner membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="18">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="7.1.1.1" evidence="2"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89427.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627136.1">
        <property type="nucleotide sequence ID" value="XM_627136.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVY3"/>
    <dbReference type="STRING" id="353152.Q5CVY3"/>
    <dbReference type="GeneID" id="3374458"/>
    <dbReference type="KEGG" id="cpv:cgd8_2330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2330"/>
    <dbReference type="InParanoid" id="Q5CVY3"/>
    <dbReference type="OMA" id="TTHKYVA"/>
    <dbReference type="OrthoDB" id="37244at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0050661">
        <property type="term" value="F:NADP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008750">
        <property type="term" value="F:proton-translocating NAD(P)+ transhydrogenase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006740">
        <property type="term" value="P:NADPH regeneration"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05304">
        <property type="entry name" value="Rubrum_tdh"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.720">
        <property type="entry name" value="NAD(P)-binding Rossmann-like Domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.1220">
        <property type="entry name" value="TPP-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007886">
        <property type="entry name" value="AlaDH/PNT_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007698">
        <property type="entry name" value="AlaDH/PNT_NAD(H)-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029035">
        <property type="entry name" value="DHS-like_NAD/FAD-binding_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036291">
        <property type="entry name" value="NAD(P)-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026255">
        <property type="entry name" value="NADP_transhyd_a"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024605">
        <property type="entry name" value="NADP_transhyd_a_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034300">
        <property type="entry name" value="PNTB-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00561">
        <property type="entry name" value="pntA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF006942">
        <property type="entry name" value="PRK09424.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160">
        <property type="entry name" value="NAD(P) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10160:SF19">
        <property type="entry name" value="PROTON-TRANSLOCATING NAD(P)(+) TRANSHYDROGENASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01262">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF05222">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02233">
        <property type="entry name" value="PNTB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12769">
        <property type="entry name" value="PNTB_4TM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01002">
        <property type="entry name" value="AlaDh_PNT_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01003">
        <property type="entry name" value="AlaDh_PNT_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52467">
        <property type="entry name" value="DHS-like NAD/FAD-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52283">
        <property type="entry name" value="Formate/glycerate dehydrogenase catalytic domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51735">
        <property type="entry name" value="NAD(P)-binding Rossmann-fold domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0997">Cell inner membrane</keyword>
    <keyword evidence="3" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="11 14" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0520">NAD</keyword>
    <keyword evidence="7" id="KW-0521">NADP</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="19" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="15" id="KW-0732">Signal</keyword>
    <keyword evidence="8" id="KW-1278">Translocase</keyword>
    <keyword evidence="5 14 18" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="9 14" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="15">
        <location>
            <begin position="1"/>
            <end position="33"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253913" description="proton-translocating NAD(P)(+) transhydrogenase" evidence="15">
        <location>
            <begin position="34"/>
            <end position="1143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="86"/>
            <end position="106"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="118"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="143"/>
            <end position="160"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="172"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="248"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="282"/>
            <end position="306"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="326"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1003"/>
            <end position="1027"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1033"/>
            <end position="1051"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1063"/>
            <end position="1085"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="14">
        <location>
            <begin position="1091"/>
            <end position="1113"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase N-terminal" evidence="17">
        <location>
            <begin position="589"/>
            <end position="724"/>
        </location>
    </feature>
    <feature type="domain" description="Alanine dehydrogenase/pyridine nucleotide transhydrogenase NAD(H)-binding" evidence="16">
        <location>
            <begin position="733"/>
            <end position="906"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="962"/>
            <end position="991"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="13">
        <location>
            <begin position="973"/>
            <end position="991"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004429"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012943"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022519"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022967"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00048202"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="SMART" id="SM01002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="17">
        <source>
            <dbReference type="SMART" id="SM01003"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="EMBL" id="EAK89427.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="19">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1143" mass="123784" checksum="E4947E81DCCB5D7D" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW18</accession>
    <name>Q5CW18_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">NAD kinase involved in polyphosphate metabolism</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd8_1970</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the NAD kinase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89689.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_627101.1"/>
    </dbReference>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
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    </dbReference>
    <dbReference type="GO" id="GO:0019674">
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006741">
        <property type="term" value="P:NADP+ biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.200.30:FF:000009">
        <property type="entry name" value="Poly(P)/ATP NAD kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10330">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.30">
        <property type="entry name" value="Probable inorganic polyphosphate/atp-NAD kinase, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00361">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017438">
        <property type="entry name" value="ATP-NAD_kinase_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017437">
        <property type="entry name" value="ATP-NAD_kinase_PpnK-typ_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016064">
        <property type="entry name" value="NAD/diacylglycerol_kinase_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002504">
        <property type="entry name" value="NADK"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20275:SF0">
        <property type="entry name" value="NAD KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01513">
        <property type="entry name" value="NAD_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF20143">
        <property type="entry name" value="NAD_kinase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF111331">
        <property type="entry name" value="NAD kinase/diacylglycerol kinase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
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    <keyword evidence="6" id="KW-0521">NADP</keyword>
    <keyword evidence="3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
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        <location>
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            <end position="458"/>
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    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="8">
        <location>
            <begin position="439"/>
            <end position="455"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="9">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010995"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022857"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023027"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89689.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="578" mass="64563" checksum="0E59690AB9F7E863" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW72</accession>
    <name>Q5CW72_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Glycerol-3-phosphate acyltransferase family, possible plant origin, possible signal peptide plus 2 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd8_1400</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89355.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627047.1">
        <property type="nucleotide sequence ID" value="XM_627047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW72"/>
    <dbReference type="FunCoup" id="Q5CW72">
        <property type="interactions" value="11"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW72"/>
    <dbReference type="GeneID" id="3374517"/>
    <dbReference type="KEGG" id="cpv:cgd8_1400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1400"/>
    <dbReference type="InParanoid" id="Q5CW72"/>
    <dbReference type="OMA" id="FYPTPGM"/>
    <dbReference type="OrthoDB" id="417078at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003841">
        <property type="term" value="F:1-acylglycerol-3-phosphate O-acyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006654">
        <property type="term" value="P:phosphatidic acid biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd07989">
        <property type="entry name" value="LPLAT_AGPAT-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002123">
        <property type="entry name" value="Plipid/glycerol_acylTrfase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10434:SF11">
        <property type="entry name" value="1-ACYL-SN-GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01553">
        <property type="entry name" value="Acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00563">
        <property type="entry name" value="PlsC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF69593">
        <property type="entry name" value="Glycerol-3-phosphate (1)-acyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 6" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="4" id="KW-0472">Membrane</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 6" id="KW-0808">Transferase</keyword>
    <keyword evidence="4 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="4">
        <location>
            <begin position="21"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="domain" description="Phospholipid/glycerol acyltransferase" evidence="5">
        <location>
            <begin position="100"/>
            <end position="223"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="299"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="283"/>
            <end position="299"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="SMART" id="SM00563"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK89355.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="299" mass="34515" checksum="4E0D39A1CF04F143" modified="2005-04-12" version="1">MAEEQTMTSIRKSSNPKWLRFIVTVYTYSMICISIILGLITQILLWIFLFPYLLYNEKFKIIIMGQAFRFWNALLVIWTNPFWTVKITREPKRNYKPSNTLIMTNHLSTADPWIISSTHFPWEFKYVYKADLLKVPIVNCAISLTYDLPIYFTKEKGGWGIKSGTIEPMFNRCAELQKLGIGQVIYPEGTRSKLRRLQPFKNGFFKFAIEHESEILPVVSHNNWSLWPLGEPLLDLGTAYVAYGDPIQVTKDMDIEELKLKVQSAMMELFKCCPTHNPELEQPLSTASSTRGHGITGTN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW79</accession>
    <name>Q5CW79_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_1330</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89349.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627040.1">
        <property type="nucleotide sequence ID" value="XM_627040.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW79"/>
    <dbReference type="GeneID" id="3374511"/>
    <dbReference type="KEGG" id="cpv:cgd8_1330"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_1330"/>
    <dbReference type="InParanoid" id="Q5CW79"/>
    <dbReference type="OMA" id="APNCLEQ"/>
    <dbReference type="OrthoDB" id="342792at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="12"/>
            <end position="30"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89349.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="293" mass="32564" checksum="64E1921AA48404BC" modified="2005-04-12" version="1">MKYCVIRYRKWIILLIIIEFVIKINLLYGLRNNVFGQLVPQQLLANSGLLPPNLVNNANLPTTSTSTQATTIIVNNPQQNTGNLASGGSFLNELFKKPSIEQLNKDIKEIMQKESSSKGFGICLFTSNPYLDLGFRDLDYEKCTKFLLSMDTWLDESTINSLIQEQLIKNGLSIPSKKKFKVPALEVLYKETFLQVCVTFFVGLVSSGLLEINNKTCTGNSCHDQFNAVCNVVFDTYGKSASILGGPTINDVVKTICQESRRQIASKYQTLISSPADIRSDNVSVEASEPIPT</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW97</accession>
    <name>Q5CW97_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">choline-phosphate cytidylyltransferase</fullName>
            <ecNumber evidence="8">2.7.7.15</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_1150</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the cytidylyltransferase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.7.15" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89672.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627022.1">
        <property type="nucleotide sequence ID" value="XM_627022.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW97"/>
    <dbReference type="STRING" id="353152.Q5CW97"/>
    <dbReference type="GeneID" id="3374637"/>
    <dbReference type="KEGG" id="cpv:cgd8_1150"/>
    <dbReference type="InParanoid" id="Q5CW97"/>
    <dbReference type="OMA" id="KANQIQM"/>
    <dbReference type="OrthoDB" id="17102at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004105">
        <property type="term" value="F:choline-phosphate cytidylyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031210">
        <property type="term" value="F:phosphatidylcholine binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02174">
        <property type="entry name" value="CCT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.620">
        <property type="entry name" value="HUPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041723">
        <property type="entry name" value="CCT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004821">
        <property type="entry name" value="Cyt_trans-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045049">
        <property type="entry name" value="Pcy1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014729">
        <property type="entry name" value="Rossmann-like_a/b/a_fold"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00125">
        <property type="entry name" value="cyt_tran_rel"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739:SF13">
        <property type="entry name" value="CHOLINE-PHOSPHATE CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10739">
        <property type="entry name" value="CYTIDYLYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01467">
        <property type="entry name" value="CTP_transf_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52374">
        <property type="entry name" value="Nucleotidylyl transferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0444">Lipid biosynthesis</keyword>
    <keyword evidence="5" id="KW-0443">Lipid metabolism</keyword>
    <keyword evidence="4 11" id="KW-0548">Nucleotidyltransferase</keyword>
    <keyword evidence="6" id="KW-0594">Phospholipid biosynthesis</keyword>
    <keyword evidence="7" id="KW-1208">Phospholipid metabolism</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 11" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Cytidyltransferase-like" evidence="10">
        <location>
            <begin position="71"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="167"/>
            <end position="186"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022516"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022695"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023098"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023209"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023264"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00026101"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF01467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89672.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="341" mass="39520" checksum="70E156ACE61A3512" modified="2005-04-12" version="1" fragment="single">LKQSCKSKPKVIKGICKKNLCKKNSEILTEDSSENGSFIDDEKSDIFNKNTLADGQENNKECDTNRKIRIYADGVYDLLHLGHMRQLEQAKKMYPNTHLIVGVASDEETHRLKGRTVQTLQERTETLRHVKWVDEIISPCPWVIDEKFVEKHKIDFVAHDDVPYVAKQKKRDEEDSSNTDCNSSEEKPVISYDQDDIYGWLKRCGKFKATQRTKGVSTTDLVVRILQNYEEYIDRSLQRGVTPDELNIGYMKANQIQMKKGIQRWGEKVTNELTKVTLTDRPLGITFDESVDNIRNQIHKSFDAWRGVSKKYLEGFARTFDPMRSLFRENRISEGESPSFK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWK4</accession>
    <name>Q5CWK4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">SNARE associated Golgi protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_4730</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cell membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90058.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627800.1">
        <property type="nucleotide sequence ID" value="XM_627800.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWK4"/>
    <dbReference type="GeneID" id="3375803"/>
    <dbReference type="KEGG" id="cpv:cgd6_4730"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4730"/>
    <dbReference type="InParanoid" id="Q5CWK4"/>
    <dbReference type="OMA" id="FIFAHIH"/>
    <dbReference type="OrthoDB" id="166803at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015414">
        <property type="entry name" value="TMEM64"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12677:SF59">
        <property type="entry name" value="GOLGI APPARATUS MEMBRANE PROTEIN TVP38-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1003">Cell membrane</keyword>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="21"/>
            <end position="41"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="61"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="103"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="155"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="183"/>
            <end position="206"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="226"/>
            <end position="246"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022475"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90058.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="9">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="278" mass="31895" checksum="E784E715BB9647C4" modified="2005-04-12" version="1">MSKNLERFSALRKIDVKIYSYMALKLAFTTILTVSIVLILYHFRDTTHWIEKFSVEVKENVIITTTISTIIISLLMTISVPIEPILVSMAFFTSSINGPTIDVLLCLFICFNATQISTFLTVIVTRFCFPKYLGEKARQYKFFSAFNEIAKERGFLLLALIRLSLFLPFVPSNCLLGLTDISFFNLFLGNFAVIPAQISLILFGASIYDNNHLKNELNTNYIHPKYALLFFSFSIISMSLLFYIIFQKFREINQKTESLLEHVNTPLSSAPFHRIDNL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX42</accession>
    <name>Q5CX42_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 14">Histone acetyltransferase</fullName>
            <ecNumber evidence="3 14">2.3.1.48</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="17" type="ORF">cgd6_2590</name>
    </gene>
    <organism evidence="17 18">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="17 18" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="18">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="14">
            <text>L-lysyl-[protein] + acetyl-CoA = N(6)-acetyl-L-lysyl-[protein] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:45948"/>
            <dbReference type="Rhea" id="RHEA-COMP:9752"/>
            <dbReference type="Rhea" id="RHEA-COMP:10731"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:29969"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:61930"/>
            <dbReference type="EC" id="2.3.1.48"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 14">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 14">Belongs to the MYST (SAS/MOZ) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="17">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.48" evidence="3 14"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89901.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627612.1">
        <property type="nucleotide sequence ID" value="XM_627612.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX42"/>
    <dbReference type="STRING" id="353152.Q5CX42"/>
    <dbReference type="GeneID" id="3376141"/>
    <dbReference type="KEGG" id="cpv:cgd6_2590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2590"/>
    <dbReference type="InParanoid" id="Q5CX42"/>
    <dbReference type="OMA" id="RIRNVEC"/>
    <dbReference type="OrthoDB" id="787137at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000785">
        <property type="term" value="C:chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003682">
        <property type="term" value="F:chromatin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004402">
        <property type="term" value="F:histone acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003712">
        <property type="term" value="F:transcription coregulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006357">
        <property type="term" value="P:regulation of transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.630.30:FF:000001">
        <property type="entry name" value="Histone acetyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.60.60">
        <property type="entry name" value="N-acetyl transferase-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016197">
        <property type="entry name" value="Chromo-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000953">
        <property type="entry name" value="Chromo/chromo_shadow_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002717">
        <property type="entry name" value="HAT_MYST-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050603">
        <property type="entry name" value="MYST_HAT"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR025995">
        <property type="entry name" value="Tudor-knot"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR040706">
        <property type="entry name" value="Zf-MYST"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10615:SF161">
        <property type="entry name" value="HISTONE ACETYLTRANSFERASE KAT7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01853">
        <property type="entry name" value="MOZ_SAS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11717">
        <property type="entry name" value="Tudor-knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17772">
        <property type="entry name" value="zf-MYST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00298">
        <property type="entry name" value="CHROMO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54160">
        <property type="entry name" value="Chromo domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51726">
        <property type="entry name" value="MYST_HAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0007">Acetylation</keyword>
    <keyword evidence="8" id="KW-0156">Chromatin regulator</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="12 14" id="KW-0539">Nucleus</keyword>
    <keyword evidence="18" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="11" id="KW-0804">Transcription</keyword>
    <keyword evidence="10" id="KW-0805">Transcription regulation</keyword>
    <keyword evidence="4 17" id="KW-0808">Transferase</keyword>
    <keyword evidence="7" id="KW-0862">Zinc</keyword>
    <keyword evidence="6" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="MYST-type HAT" evidence="16">
        <location>
            <begin position="247"/>
            <end position="537"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="1"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="15">
        <location>
            <begin position="206"/>
            <end position="240"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="8"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="15">
        <location>
            <begin position="19"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="15">
        <location>
            <begin position="30"/>
            <end position="40"/>
        </location>
    </feature>
    <feature type="active site" description="Proton donor/acceptor" evidence="13">
        <location>
            <position position="423"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010107"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013184"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022853"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022990"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="PIRSR" id="PIRSR602717-51"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="RuleBase" id="RU361211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="16">
        <source>
            <dbReference type="PROSITE" id="PS51726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="EMBL" id="EAK89901.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="18">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="552" mass="63791" checksum="78EAE71429F37CF3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX53</accession>
    <name>Q5CX53_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60s ribosomal protein L21</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_2460</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL21 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89892.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627601.1">
        <property type="nucleotide sequence ID" value="XM_627601.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX53"/>
    <dbReference type="FunCoup" id="Q5CX53">
        <property type="interactions" value="387"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CX53"/>
    <dbReference type="GeneID" id="3376132"/>
    <dbReference type="KEGG" id="cpv:cgd6_2460"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2460"/>
    <dbReference type="InParanoid" id="Q5CX53"/>
    <dbReference type="OMA" id="INYGDYV"/>
    <dbReference type="OrthoDB" id="1539250at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.70:FF:000001">
        <property type="entry name" value="60S ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="6.10.250.3260">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.70">
        <property type="entry name" value="Ribosomal protein L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001147">
        <property type="entry name" value="Ribosomal_eL21"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018259">
        <property type="entry name" value="Ribosomal_eL21_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036948">
        <property type="entry name" value="Ribosomal_eL21_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008991">
        <property type="entry name" value="Translation_prot_SH3-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20981">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L21"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01157">
        <property type="entry name" value="Ribosomal_L21e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50104">
        <property type="entry name" value="Translation proteins SH3-like domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01171">
        <property type="entry name" value="RIBOSOMAL_L21E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008427"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89892.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="159" mass="17882" checksum="15A4702DD832469D" modified="2007-04-03" version="1">MPHSFGKRARTRSKFSKGFRQKGVPMLSRYLKPIKVGDYVDIVVDSSIHKGMPYHFYHGRTGVVYNVAPRALGVIVNKVVGNRQIAKRINVRIEHVRLSRCNEDFLKRVKANDAARHEAHVAGLPSPVTKRVPQLPREGGFVDCSNMEVLTPHITVSIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX61</accession>
    <name>Q5CX61_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Mitochondrial FAD carrier protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd6_2360</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the mitochondrial carrier (TC 2.A.29) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89886.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627593.1">
        <property type="nucleotide sequence ID" value="XM_627593.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX61"/>
    <dbReference type="STRING" id="353152.Q5CX61"/>
    <dbReference type="GeneID" id="3376184"/>
    <dbReference type="KEGG" id="cpv:cgd6_2360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2360"/>
    <dbReference type="InParanoid" id="Q5CX61"/>
    <dbReference type="OMA" id="WNGISTH"/>
    <dbReference type="OrthoDB" id="10253709at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006862">
        <property type="term" value="P:nucleotide transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0055085">
        <property type="term" value="P:transmembrane transport"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.50.40.10">
        <property type="entry name" value="Mitochondrial carrier domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023395">
        <property type="entry name" value="MCP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018108">
        <property type="entry name" value="MCP_transmembrane"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044712">
        <property type="entry name" value="SLC25A32-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45683">
        <property type="entry name" value="MITOCHONDRIAL NICOTINAMIDE ADENINE DINUCLEOTIDE TRANSPORTER 1-RELATED-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103506">
        <property type="entry name" value="Mitochondrial carrier"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50920">
        <property type="entry name" value="SOLCAR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0677">Repeat</keyword>
    <keyword evidence="4 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="repeat" description="Solcar" evidence="8">
        <location>
            <begin position="130"/>
            <end position="231"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00282"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAK89886.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="329" mass="37837" checksum="70A2C04E53E77ACC" modified="2007-04-03" version="1">MNFPKIKLNEQWQLLRLYGVLNSPQLVLIYPVYTIQLKSMCLPYFESYLENSNSIESAHSTTSSSRISRGIIYNLSGIKLIFDSLRCIYNEEGYWGLYRGFIPMTLHSYFTRILHDQLLKVYKRHSKVHDSFIKPVYVKSSAKYISEIITYPLLVISTQQAIFDVKRYNLGLQDDKDKIEESVIGIYSLIQLSVNSEEGITSLWKGVTAHIIFRITEDLIKNSLYSYLSINYQRAKDTEDKLLATKTKPHNKKHLKHGVSNFTTSLLSPLALISTVKRCQSSDHIGLCRGDVGIKEILGNVNWGIYFGQMAVNSIFIAIYLFDRENSLF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXH4</accession>
    <name>Q5CXH4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">Glycoprotein 60 Cryptosporidium spp domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_1080</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89793.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627480.1">
        <property type="nucleotide sequence ID" value="XM_627480.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXH4"/>
    <dbReference type="STRING" id="353152.Q5CXH4"/>
    <dbReference type="GeneID" id="3376025"/>
    <dbReference type="KEGG" id="cpv:cgd6_1080"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1080"/>
    <dbReference type="InParanoid" id="Q5CXH4"/>
    <dbReference type="OrthoDB" id="344254at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021035">
        <property type="entry name" value="Glycop-60_Cryptosporidium"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11025">
        <property type="entry name" value="GP40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="19"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004255056" description="Glycoprotein 60 Cryptosporidium spp domain-containing protein" evidence="2">
        <location>
            <begin position="20"/>
            <end position="324"/>
        </location>
    </feature>
    <feature type="domain" description="Glycoprotein 60 Cryptosporidium spp" evidence="3">
        <location>
            <begin position="119"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="29"/>
            <end position="122"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="192"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="75"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="86"/>
            <end position="95"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="99"/>
            <end position="117"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="192"/>
            <end position="203"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF11025"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89793.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="324" mass="33451" checksum="2BC90B0312453DD6" modified="2007-04-03" version="1">MRLSLIIVLLSVIVSAVFSAPAVPLRGTLKDVPVEGSSSSSSSSSSSSSSSSSTSTVAPANKARTGEDAEGSQDSSGTEASGSQGSEEEGSEDDGQTSAASQPTTPAQSEGATTETIEATPKEECGTSFVMWFGEGTPAATLKCGAYTIVYAPIKDQTDPAPRYISGEVTSVTFEKSDNTVKIKVNGQDFSTLSANSSSPTENGGSAGQASSRSRRSLSEETSEAAATVDLFAFTLDGGKRIEVAVPNVEDASKRDKYSLVADDKPFYTGANSGTTNGVYRLNENGDLVDKDNTVLLKDAGSSAFGLRYIVPSVFAIFAALFVL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXN0</accession>
    <name>Q5CXN0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Sgn1p-like RRM domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_410</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89746.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627424.1">
        <property type="nucleotide sequence ID" value="XM_627424.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXN0"/>
    <dbReference type="FunCoup" id="Q5CXN0">
        <property type="interactions" value="283"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXN0"/>
    <dbReference type="GeneID" id="3376103"/>
    <dbReference type="KEGG" id="cpv:cgd6_410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_410"/>
    <dbReference type="InParanoid" id="Q5CXN0"/>
    <dbReference type="OMA" id="YRGRATY"/>
    <dbReference type="OrthoDB" id="4726at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008143">
        <property type="term" value="F:poly(A) binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd12306">
        <property type="entry name" value="RRM_II_PABPs"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236">
        <property type="entry name" value="EUKARYOTIC TRANSLATION INITIATION FACTOR 4B/4H"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23236:SF92">
        <property type="entry name" value="POLYADENYLATE-BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="110"/>
            <end position="187"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="1"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="22"/>
            <end position="32"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="3">
        <location>
            <begin position="35"/>
            <end position="68"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="3">
        <location>
            <begin position="77"/>
            <end position="87"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89746.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="262" mass="27892" checksum="2576643815F074BE" modified="2005-04-12" version="1">MDSVNQIGLDESFSNELKDTKMANNPNLSRSDIISGPTNSGANNNNNNNVGATNSSSSSSGLSGTPSAIGTNLFDLSDNKSLNDESNKNVGESMMDTDLPGSADDEEMKRSIYIGNVDYGTKLTELQDLFKSCGSINRITIMNDKRTGMPKGFAYLEFCEPEAVETALKFDGAMFRGRQIKVSTKRKNIPGYNRGRGMGPGGGFRGGMGRGGFRGGYSRGGMMSGGHGPNMRGYYGNPYKSYRGGGGGVGGYSGNRHIVNPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXP7</accession>
    <name>Q5CXP7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_5400</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90490.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628683.1">
        <property type="nucleotide sequence ID" value="XM_628681.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXP7"/>
    <dbReference type="GeneID" id="3372147"/>
    <dbReference type="KEGG" id="cpv:cgd7_5400"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5400"/>
    <dbReference type="InParanoid" id="Q5CXP7"/>
    <dbReference type="OrthoDB" id="343971at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253949" evidence="2">
        <location>
            <begin position="19"/>
            <end position="202"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="159"/>
            <end position="179"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90490.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="202" mass="23408" checksum="5A8B0187A4150062" modified="2005-04-12" version="1">MNFLILLLLVLCFRYVLSQRNVAQERHDFSGSTNPAEMYGPQKLKSDYKPLPWKDKFPRYDANITEILELHKLTEKKPEFEPILTRKQEKGVDNRVPELIRPVQVRCPKGWTPWGPLCMAEVSLGPRTECFGDLGRFVSSASGTIPKQSSLYPGNFAKYSFWLTVINLLILNIIYFLFIKNRNLPGKKRSRTFFSMSSRNET</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXT7</accession>
    <name>Q5CXT7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="6">Ubiquitin ligase with a HECT domain at the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_4990</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628643.1">
        <property type="nucleotide sequence ID" value="XM_628641.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXT7"/>
    <dbReference type="GeneID" id="3372235"/>
    <dbReference type="KEGG" id="cpv:cgd7_4990"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4990"/>
    <dbReference type="InParanoid" id="Q5CXT7"/>
    <dbReference type="OMA" id="CSINTEY"/>
    <dbReference type="OrthoDB" id="271273at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016874">
        <property type="term" value="F:ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004842">
        <property type="term" value="F:ubiquitin-protein transferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.20">
        <property type="entry name" value="Ankyrin repeat-containing domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2160.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.2410.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1750.10">
        <property type="entry name" value="Hect, E3 ligase catalytic domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002110">
        <property type="entry name" value="Ankyrin_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036770">
        <property type="entry name" value="Ankyrin_rpt-contain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000569">
        <property type="entry name" value="HECT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035983">
        <property type="entry name" value="Hect_E3_ubiquitin_ligase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042469">
        <property type="entry name" value="HECTD3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46654:SF1">
        <property type="entry name" value="E3 UBIQUITIN-PROTEIN LIGASE HECTD3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00632">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00248">
        <property type="entry name" value="ANK"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00119">
        <property type="entry name" value="HECTc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48403">
        <property type="entry name" value="Ankyrin repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56204">
        <property type="entry name" value="Hect, E3 ligase catalytic domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50088">
        <property type="entry name" value="ANK_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50237">
        <property type="entry name" value="HECT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0040">ANK repeat</keyword>
    <keyword evidence="6" id="KW-0436">Ligase</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0833">Ubl conjugation pathway</keyword>
    <feature type="repeat" description="ANK" evidence="2">
        <location>
            <begin position="4877"/>
            <end position="4909"/>
        </location>
    </feature>
    <feature type="domain" description="HECT" evidence="5">
        <location>
            <begin position="6372"/>
            <end position="6673"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="1067"/>
            <end position="1086"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2534"/>
            <end position="2597"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="2687"/>
            <end position="2707"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="4931"/>
            <end position="4969"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="5196"/>
            <end position="5280"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="6230"/>
            <end position="6315"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="6438"/>
            <end position="6468"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="1071"/>
            <end position="1082"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2553"/>
            <end position="2572"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="2694"/>
            <end position="2705"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="5214"/>
            <end position="5239"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="5245"/>
            <end position="5260"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="5267"/>
            <end position="5280"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="6244"/>
            <end position="6262"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="6273"/>
            <end position="6286"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="6290"/>
            <end position="6314"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="4">
        <location>
            <begin position="6445"/>
            <end position="6465"/>
        </location>
    </feature>
    <feature type="active site" description="Glycyl thioester intermediate" evidence="3">
        <location>
            <position position="6641"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00023"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00104"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50237"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="6680" mass="764351" checksum="61D4428E663AC0C6" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="81" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXU9</accession>
    <name>Q5CXU9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Phosducin related thioredoxin fold protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_4840</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the phosducin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90451.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628631.1">
        <property type="nucleotide sequence ID" value="XM_628629.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXU9"/>
    <dbReference type="SMR" id="Q5CXU9"/>
    <dbReference type="FunCoup" id="Q5CXU9">
        <property type="interactions" value="6"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXU9"/>
    <dbReference type="GeneID" id="3372224"/>
    <dbReference type="KEGG" id="cpv:cgd7_4840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4840"/>
    <dbReference type="InParanoid" id="Q5CXU9"/>
    <dbReference type="OMA" id="FCEIRAN"/>
    <dbReference type="OrthoDB" id="45518at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006457">
        <property type="term" value="P:protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd02988">
        <property type="entry name" value="Phd_like_VIAF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.30.10">
        <property type="entry name" value="Glutaredoxin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051498">
        <property type="entry name" value="Phosducin-like_chap/apop_reg"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR024253">
        <property type="entry name" value="Phosducin_thioredoxin-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036249">
        <property type="entry name" value="Thioredoxin-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45809:SF3">
        <property type="entry name" value="VIRAL IAP-ASSOCIATED FACTOR HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02114">
        <property type="entry name" value="Phosducin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52833">
        <property type="entry name" value="Thioredoxin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Phosducin" evidence="3">
        <location>
            <begin position="62"/>
            <end position="182"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="221"/>
            <end position="251"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009686"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02114"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90451.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="268" mass="31088" checksum="8CCC593409F85D67" modified="2005-04-12" version="1">MSTTNPTEITTQWEDQMVKRGIWAPREQEKKNEELYKERIDALESINLFENAKLEKLIDVEVDKDESFEKELVAIRARRLASLKNRAEENSRFGELYFIRKPDFVKEVTEASKDNTTVVVHLYKESNEDCQIINRLLSETIAKEYGKIKFVKGISSDIVPNYPDKSLPTMIIYRNGTSISQITGSSSFKDKNRKITIKSILKLFVQNNVIKNSEITEHSRFEKGSEYSNNYSSSDDSDSDDDNRDNGKCYSSTVFDKMQDRIKYLQKI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="78" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXV4</accession>
    <name>Q5CXV4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Protein phosphatase</fullName>
            <ecNumber evidence="1">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_4790</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="1">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628626.1">
        <property type="nucleotide sequence ID" value="XM_628624.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXV4"/>
    <dbReference type="STRING" id="353152.Q5CXV4"/>
    <dbReference type="GeneID" id="3372220"/>
    <dbReference type="KEGG" id="cpv:cgd7_4790"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4790"/>
    <dbReference type="InParanoid" id="Q5CXV4"/>
    <dbReference type="OMA" id="NIMCIAD"/>
    <dbReference type="OrthoDB" id="60843at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039123">
        <property type="entry name" value="PPTC7"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12320:SF1">
        <property type="entry name" value="PROTEIN PHOSPHATASE PTC7 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="1" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0460">Magnesium</keyword>
    <keyword evidence="1" id="KW-0464">Manganese</keyword>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="1" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="3">
        <location>
            <begin position="287"/>
            <end position="663"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="62"/>
            <end position="116"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="188"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="62"/>
            <end position="88"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="188"/>
            <end position="207"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="RuleBase" id="RU366020"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="684" mass="77118" checksum="960494610B31DFC0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYA9</accession>
    <name>Q5CYA9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane protein conserved in eukaryotes</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_3040</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90314.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628471.1">
        <property type="nucleotide sequence ID" value="XM_628469.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYA9"/>
    <dbReference type="GeneID" id="3372287"/>
    <dbReference type="KEGG" id="cpv:cgd7_3040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3040"/>
    <dbReference type="InParanoid" id="Q5CYA9"/>
    <dbReference type="OMA" id="NIWYDYW"/>
    <dbReference type="OrthoDB" id="67700at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052299">
        <property type="entry name" value="CEP76"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056288">
        <property type="entry name" value="CEP76_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056290">
        <property type="entry name" value="CEPT76/DRC7_peptidase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436">
        <property type="entry name" value="CENTROSOMAL PROTEIN OF 76 KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46436:SF2">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_119, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24652">
        <property type="entry name" value="CEP76_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF24656">
        <property type="entry name" value="CEPT76_peptidase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="CEP76/DRC7 peptidase-like" evidence="4">
        <location>
            <begin position="821"/>
            <end position="975"/>
        </location>
    </feature>
    <feature type="domain" description="Centrosomal protein of 76 kDa C-terminal" evidence="3">
        <location>
            <begin position="1003"/>
            <end position="1139"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="786"/>
            <end position="806"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1386"/>
            <end position="1464"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1145"/>
            <end position="1174"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="2">
        <location>
            <begin position="1386"/>
            <end position="1416"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1420"/>
            <end position="1433"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF24652"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="Pfam" id="PF24656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90314.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1654" mass="190739" checksum="56C1B3BC0BE77FD8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYN9</accession>
    <name>Q5CYN9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_1610</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90210.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628341.1">
        <property type="nucleotide sequence ID" value="XM_628339.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYN9"/>
    <dbReference type="GeneID" id="3372256"/>
    <dbReference type="KEGG" id="cpv:cgd7_1610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1610"/>
    <dbReference type="InParanoid" id="Q5CYN9"/>
    <dbReference type="OMA" id="DSIDICE"/>
    <dbReference type="OrthoDB" id="339191at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90210.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1002" mass="115349" checksum="6747C3238D718C99" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="90" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYQ0</accession>
    <name>Q5CYQ0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">40S ribosomal protein S27</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_1460</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="5">
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </cofactor>
        <text evidence="5">Binds 1 zinc ion per subunit.</text>
    </comment>
    <comment type="similarity">
        <text evidence="1 5">Belongs to the eukaryotic ribosomal protein eS27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628330.1">
        <property type="nucleotide sequence ID" value="XM_628328.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYQ0"/>
    <dbReference type="FunCoup" id="Q5CYQ0">
        <property type="interactions" value="294"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYQ0"/>
    <dbReference type="GeneID" id="3371860"/>
    <dbReference type="KEGG" id="cpv:cgd7_1460"/>
    <dbReference type="InParanoid" id="Q5CYQ0"/>
    <dbReference type="OMA" id="CASILCQ"/>
    <dbReference type="OrthoDB" id="5567124at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="2.20.25.100:FF:000001">
        <property type="entry name" value="40S ribosomal protein S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.25.100">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00371">
        <property type="entry name" value="Ribosomal_eS27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000592">
        <property type="entry name" value="Ribosomal_eS27"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023407">
        <property type="entry name" value="Ribosomal_eS27_Zn-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011332">
        <property type="entry name" value="Ribosomal_zn-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11594">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN S27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01667">
        <property type="entry name" value="Ribosomal_S27e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57829">
        <property type="entry name" value="Zn-binding ribosomal proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01168">
        <property type="entry name" value="RIBOSOMAL_S27E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 5" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="3 5 6" id="KW-0689">Ribosomal protein</keyword>
    <keyword evidence="2 5" id="KW-0862">Zinc</keyword>
    <keyword evidence="5" id="KW-0863">Zinc-finger</keyword>
    <feature type="non-terminal residue" evidence="6">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00010919"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU000671"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="86" mass="9609" checksum="25F88A48FB5ED2B2" modified="2005-04-12" version="1" fragment="single">IKLIMDINLLNPDPRVEAQKHKLKRLIQSPNSFFMDVRCPGCLQITTVFSHAQSVVFCGNCSAPLCQPTGGRCKLTDGCSFRRKND</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYQ5</accession>
    <name>Q5CYQ5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">AAA domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_1410</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90195.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628325.1">
        <property type="nucleotide sequence ID" value="XM_628323.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYQ5"/>
    <dbReference type="FunCoup" id="Q5CYQ5">
        <property type="interactions" value="49"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYQ5"/>
    <dbReference type="GeneID" id="3372241"/>
    <dbReference type="KEGG" id="cpv:cgd7_1410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1410"/>
    <dbReference type="InParanoid" id="Q5CYQ5"/>
    <dbReference type="OMA" id="HKSITGG"/>
    <dbReference type="OrthoDB" id="199596at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021911">
        <property type="entry name" value="ATAD3_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075:SF12">
        <property type="entry name" value="AAA+ ATPASE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23075">
        <property type="entry name" value="PUTATIVE ATP-ASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12037">
        <property type="entry name" value="ATAD3_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="6">
        <location>
            <begin position="358"/>
            <end position="494"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="1"/>
            <end position="49"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="598"/>
            <end position="627"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="4">
        <location>
            <begin position="137"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="5">
        <location>
            <begin position="27"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="598"/>
            <end position="615"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="616"/>
            <end position="627"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90195.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="627" mass="70456" checksum="30BFA7D651E66B13" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYR0</accession>
    <name>Q5CYR0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein with signal peptide and Sec14d domain, probably secreted</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_1360</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90190.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628320.1">
        <property type="nucleotide sequence ID" value="XM_628318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYR0"/>
    <dbReference type="GeneID" id="3372261"/>
    <dbReference type="KEGG" id="cpv:cgd7_1360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1360"/>
    <dbReference type="InParanoid" id="Q5CYR0"/>
    <dbReference type="OMA" id="KSSICAD"/>
    <dbReference type="OrthoDB" id="7777654at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd00170">
        <property type="entry name" value="SEC14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.525.10">
        <property type="entry name" value="CRAL-TRIO lipid binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001251">
        <property type="entry name" value="CRAL-TRIO_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036865">
        <property type="entry name" value="CRAL-TRIO_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46818:SF1">
        <property type="entry name" value="CHROMOSOME UNDETERMINED SCAFFOLD_125, WHOLE GENOME SHOTGUN SEQUENCE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46818">
        <property type="entry name" value="DOMAIN-CONTAINING PROTEIN, PUTATIVE-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00650">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52087">
        <property type="entry name" value="CRAL/TRIO domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50191">
        <property type="entry name" value="CRAL_TRIO"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253989" evidence="3">
        <location>
            <begin position="29"/>
            <end position="1012"/>
        </location>
    </feature>
    <feature type="domain" description="CRAL-TRIO" evidence="4">
        <location>
            <begin position="446"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="699"/>
            <end position="766"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="884"/>
            <end position="911"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="706"/>
            <end position="718"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="738"/>
            <end position="749"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="757"/>
            <end position="766"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50191"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90190.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1012" mass="116500" checksum="2D5CBAD2097F3149" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="83" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYX4</accession>
    <name>Q5CYX4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Cyclin possible cyclin A</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90549.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628256.1">
        <property type="nucleotide sequence ID" value="XM_628254.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYX4"/>
    <dbReference type="GeneID" id="3372010"/>
    <dbReference type="KEGG" id="cpv:cgd7_660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_660"/>
    <dbReference type="InParanoid" id="Q5CYX4"/>
    <dbReference type="OMA" id="HINDMQV"/>
    <dbReference type="OrthoDB" id="5590282at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016538">
        <property type="term" value="F:cyclin-dependent protein serine/threonine kinase regulator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0044772">
        <property type="term" value="P:mitotic cell cycle phase transition"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.10">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036915">
        <property type="entry name" value="Cyclin-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004367">
        <property type="entry name" value="Cyclin_C-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006671">
        <property type="entry name" value="Cyclin_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02984">
        <property type="entry name" value="Cyclin_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00134">
        <property type="entry name" value="Cyclin_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47954">
        <property type="entry name" value="Cyclin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0195">Cyclin</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Cyclin N-terminal" evidence="2">
        <location>
            <begin position="43"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="domain" description="Cyclin C-terminal" evidence="3">
        <location>
            <begin position="181"/>
            <end position="280"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023127"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="Pfam" id="PF00134"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="Pfam" id="PF02984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90549.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="282" mass="33038" checksum="DB5B6563D349188D" modified="2005-04-12" version="1">MKNTRLKKVQVIRNQKENESSTIESKHKLLSERDETYYSAMKLVEENMWTKWGLLKVDPETQEIQITMFKILNELGLMYQVKFVSIYLMFLMRNFWDQVLLNTDKSFANKSHAYKNNLLMVSCIFISSNYEELDPPSYTRIVQIVYDSGFKMKSGEKIIRKQVHILERLAWELTGFQVELPSANSFLMQIIQNSTLPKSKKFRVSKLSTEIIHNSLNTQAVIKYKQSLIATSSIVLAITMEYEKQPEKKQVHIDEVLKYSGYSNKQVQVVRKILENLVSSRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="107" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CZ02</accession>
    <name>Q5CZ02_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Heat shock protein, Hsp70</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_360</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum lumen</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the heat shock protein 70 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628228.1">
        <property type="nucleotide sequence ID" value="XM_628226.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CZ02"/>
    <dbReference type="SMR" id="Q5CZ02"/>
    <dbReference type="FunCoup" id="Q5CZ02">
        <property type="interactions" value="219"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CZ02"/>
    <dbReference type="GeneID" id="3371904"/>
    <dbReference type="KEGG" id="cpv:cgd7_360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_360"/>
    <dbReference type="InParanoid" id="Q5CZ02"/>
    <dbReference type="OMA" id="VQRDIKH"/>
    <dbReference type="OrthoDB" id="2401965at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140662">
        <property type="term" value="F:ATP-dependent protein folding chaperone"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006986">
        <property type="term" value="P:response to unfolded protein"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="CDD" id="cd10241">
        <property type="entry name" value="ASKHA_NBD_HSP70_BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.640.10:FF:000153">
        <property type="entry name" value="Endoplasmic reticulum chaperone BiP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.60.34.10:FF:000002">
        <property type="entry name" value="Heat shock 70 kDa"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.30.30:FF:000001">
        <property type="entry name" value="heat shock 70 kDa protein-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.420.40:FF:000026">
        <property type="entry name" value="Heat shock protein 70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1270.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.420.40">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.640.10">
        <property type="entry name" value="Actin, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.34.10">
        <property type="entry name" value="Substrate Binding Domain Of DNAk, Chain A, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043129">
        <property type="entry name" value="ATPase_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042050">
        <property type="entry name" value="BIP_NBD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018181">
        <property type="entry name" value="Heat_shock_70_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029048">
        <property type="entry name" value="HSP70_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029047">
        <property type="entry name" value="HSP70_peptide-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013126">
        <property type="entry name" value="Hsp_70_fam"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF001413">
        <property type="entry name" value="PRK00290.1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19375">
        <property type="entry name" value="HEAT SHOCK PROTEIN 70KDA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00012">
        <property type="entry name" value="HSP70"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00301">
        <property type="entry name" value="HEATSHOCK70"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53067">
        <property type="entry name" value="Actin-like ATPase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100934">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF100920">
        <property type="entry name" value="Heat shock protein 70kD (HSP70), peptide-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00297">
        <property type="entry name" value="HSP70_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00329">
        <property type="entry name" value="HSP70_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01036">
        <property type="entry name" value="HSP70_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4 7" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0732">Signal</keyword>
    <keyword evidence="10" id="KW-0346">Stress response</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253996" evidence="9">
        <location>
            <begin position="24"/>
            <end position="655"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="8">
        <location>
            <begin position="568"/>
            <end position="595"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004319"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00007381"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="655" mass="71871" checksum="5B8B556243226A80" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPN4</accession>
    <name>A3FPN4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">DNA-(apurinic or apyrimidinic site) lyase</fullName>
            <ecNumber evidence="3">4.2.99.18</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="14" type="ORF">cgd7_1720</name>
    </gene>
    <organism evidence="14 15">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="14 15" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="15">Iowa II</strain>
        </source>
    </reference>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>[4Fe-4S] cluster</name>
            <dbReference type="ChEBI" id="CHEBI:49883"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the Nth/MutY family.</text>
    </comment>
    <comment type="caution">
        <text evidence="14">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="4.2.99.18" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51573.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388380.1">
        <property type="nucleotide sequence ID" value="XM_001388343.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPN4"/>
    <dbReference type="STRING" id="353152.A3FPN4"/>
    <dbReference type="GeneID" id="3371822"/>
    <dbReference type="KEGG" id="cpv:cgd7_1720"/>
    <dbReference type="InParanoid" id="A3FPN4"/>
    <dbReference type="OMA" id="QIIWYGR"/>
    <dbReference type="OrthoDB" id="2099276at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051539">
        <property type="term" value="F:4 iron, 4 sulfur cluster binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140078">
        <property type="term" value="F:class I DNA-(apurinic or apyrimidinic site) endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000703">
        <property type="term" value="F:oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006285">
        <property type="term" value="P:base-excision repair, AP site formation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006289">
        <property type="term" value="P:nucleotide-excision repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00056">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.340.30:FF:000005">
        <property type="entry name" value="Endonuclease III-like protein 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1670.10">
        <property type="entry name" value="Helix-hairpin-Helix base-excision DNA repair enzymes (C-terminal)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.340.30">
        <property type="entry name" value="Hypothetical protein, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011257">
        <property type="entry name" value="DNA_glycosylase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004036">
        <property type="entry name" value="Endonuclease-III-like_CS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003651">
        <property type="entry name" value="Endonuclease3_FeS-loop_motif"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004035">
        <property type="entry name" value="Endouclease-III_FeS-bd_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003265">
        <property type="entry name" value="HhH-GPD_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023170">
        <property type="entry name" value="HhH_base_excis_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000445">
        <property type="entry name" value="HhH_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43286:SF1">
        <property type="entry name" value="ENDONUCLEASE III-LIKE PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF10576">
        <property type="entry name" value="EndIII_4Fe-2S"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00633">
        <property type="entry name" value="HHH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00730">
        <property type="entry name" value="HhH-GPD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF001435">
        <property type="entry name" value="Nth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00478">
        <property type="entry name" value="ENDO3c"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00525">
        <property type="entry name" value="FES"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48150">
        <property type="entry name" value="DNA-glycosylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00764">
        <property type="entry name" value="ENDONUCLEASE_III_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01155">
        <property type="entry name" value="ENDONUCLEASE_III_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0004">4Fe-4S</keyword>
    <keyword evidence="6" id="KW-0227">DNA damage</keyword>
    <keyword evidence="10" id="KW-0234">DNA repair</keyword>
    <keyword evidence="14" id="KW-0255">Endonuclease</keyword>
    <keyword evidence="12" id="KW-0326">Glycosidase</keyword>
    <keyword evidence="7" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="8" id="KW-0408">Iron</keyword>
    <keyword evidence="9" id="KW-0411">Iron-sulfur</keyword>
    <keyword evidence="11" id="KW-0456">Lyase</keyword>
    <keyword evidence="5" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="14" id="KW-0540">Nuclease</keyword>
    <keyword evidence="15" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="HhH-GPD" evidence="13">
        <location>
            <begin position="10"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="14">
        <location>
            <position position="189"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001966"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012720"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022485"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023004"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023014"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00023239"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00023295"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="SMART" id="SM00478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="EMBL" id="EAZ51573.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="15">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="189" mass="21589" checksum="2CEA3B9C642512B0" modified="2007-04-03" version="1" fragment="single">RFHVLVAAFLSSQTKDEVTAACMNRLIDNGLSPEFINNQSVDSLRDMLYGVGFYNTKAKNLKEISRIIIQNYSGKVPEKYEQLVMLPGIGPKMANLILQIGFGIVVGISVDTHMHRIFNRIGWVKTKNPIETSKEMEKMLPRIYWNDINKVFVGYGQTICKPINPKCQECNIRDYCSHGMKWKKKASTK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="109" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPP2</accession>
    <name>A3FPP2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Serine/threonine-protein phosphatase</fullName>
            <ecNumber evidence="8">3.1.3.16</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_2670</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="6">
            <text>O-phospho-L-seryl-[protein] + H2O = L-seryl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:20629"/>
            <dbReference type="Rhea" id="RHEA-COMP:9863"/>
            <dbReference type="Rhea" id="RHEA-COMP:11604"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:29999"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:83421"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="7">
            <text>O-phospho-L-threonyl-[protein] + H2O = L-threonyl-[protein] + phosphate</text>
            <dbReference type="Rhea" id="RHEA:47004"/>
            <dbReference type="Rhea" id="RHEA-COMP:11060"/>
            <dbReference type="Rhea" id="RHEA-COMP:11605"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:30013"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:61977"/>
            <dbReference type="EC" id="3.1.3.16"/>
        </reaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29035"/>
        </cofactor>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the PPP phosphatase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.1.3.16" evidence="8"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51581.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388388.1">
        <property type="nucleotide sequence ID" value="XM_001388351.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPP2"/>
    <dbReference type="FunCoup" id="A3FPP2">
        <property type="interactions" value="242"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPP2"/>
    <dbReference type="GeneID" id="3371830"/>
    <dbReference type="KEGG" id="cpv:cgd7_2670"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2670"/>
    <dbReference type="InParanoid" id="A3FPP2"/>
    <dbReference type="OMA" id="EEHEIRY"/>
    <dbReference type="OrthoDB" id="1930084at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="CDD" id="cd07414">
        <property type="entry name" value="MPP_PP1_PPKL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.60.21.10:FF:000004">
        <property type="entry name" value="Serine/threonine-protein phosphatase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.21.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004843">
        <property type="entry name" value="Calcineurin-like_PHP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029052">
        <property type="entry name" value="Metallo-depent_PP-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050341">
        <property type="entry name" value="PP1_catalytic_subunit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006186">
        <property type="entry name" value="Ser/Thr-sp_prot-phosphatase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031675">
        <property type="entry name" value="STPPase_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668">
        <property type="entry name" value="SERINE/THREONINE PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11668:SF300">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00149">
        <property type="entry name" value="Metallophos"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16891">
        <property type="entry name" value="STPPase_N"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00114">
        <property type="entry name" value="STPHPHTASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00156">
        <property type="entry name" value="PP2Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56300">
        <property type="entry name" value="Metallo-dependent phosphatases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00125">
        <property type="entry name" value="SER_THR_PHOSPHATASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="5" id="KW-0464">Manganese</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Serine/threonine specific protein phosphatases" evidence="9">
        <location>
            <begin position="135"/>
            <end position="140"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001936"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023211"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00047761"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00048336"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004273"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51581.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="320" mass="36537" checksum="9129417A190ADEA6" modified="2007-04-03" version="1">MTPQPSSTTISGTANGSNNDIDVDSIIAKLLEVRGSRPGKPVQLTEKEIRGICIKSREIFMSQPTLLELDAPIKICGDIHGQYYDLLRLFEYGGFPPDTNYLFLGDYVDRGKQSLETICLLFAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNVKLWKTFTDCFNCLPVAAIIDEKILCMHGGLSPELHKLDQIRKIERPTDVPDTGLLCDLLWSDPEKDVRGWGENDRGVSFTFGHDVVEKFLRDHDMDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPVEKKKLKP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPR0</accession>
    <name>A3FPR0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">RNA polymerase II, putative</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_4370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAZ51599.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388406.1">
        <property type="nucleotide sequence ID" value="XM_001388369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPR0"/>
    <dbReference type="FunCoup" id="A3FPR0">
        <property type="interactions" value="200"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPR0"/>
    <dbReference type="GeneID" id="3371808"/>
    <dbReference type="KEGG" id="cpv:cgd7_4370"/>
    <dbReference type="InParanoid" id="A3FPR0"/>
    <dbReference type="OrthoDB" id="10248581at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005665">
        <property type="term" value="C:RNA polymerase II, core complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003899">
        <property type="term" value="F:DNA-directed RNA polymerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046983">
        <property type="term" value="F:protein dimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006366">
        <property type="term" value="P:transcription by RNA polymerase II"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06926">
        <property type="entry name" value="RNAP_II_RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.10">
        <property type="entry name" value="RNA polymerase, RBP11-like subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00261">
        <property type="entry name" value="RNApol_arch_Rpo11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037685">
        <property type="entry name" value="RBP11"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036603">
        <property type="entry name" value="RBP11-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009025">
        <property type="entry name" value="RBP11-like_dimer"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008193">
        <property type="entry name" value="RNA_pol_Rpb11_13-16kDa_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022905">
        <property type="entry name" value="Rpo11-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE I,II,III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13946:SF16">
        <property type="entry name" value="DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13656">
        <property type="entry name" value="RNA_pol_L_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55257">
        <property type="entry name" value="RBP11-like subunits of RNA polymerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01154">
        <property type="entry name" value="RNA_POL_L_13KD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0240">DNA-directed RNA polymerase</keyword>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0804">Transcription</keyword>
    <feature type="domain" description="DNA-directed RNA polymerase RBP11-like dimerisation" evidence="6">
        <location>
            <begin position="31"/>
            <end position="101"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022478"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00025751"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF13656"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAZ51599.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="115" mass="13364" checksum="55E906EA6DCC8C43" modified="2007-04-03" version="1">MNYTNIADLYNLLTNFRVQWKVESRVPCCGSFMIMLEDHTLGNLITTQLLRDPNVIFAGYKVPHPLEPLVQIRIQTRENTTPFVAIQNAIKSIQMESQVILNSFKDSMRNYPIYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="92" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPU5</accession>
    <name>A3FPU5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3 7">DNA topoisomerase</fullName>
            <ecNumber evidence="3 7">5.6.2.1</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_2390</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 7">
            <text>ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.</text>
            <dbReference type="EC" id="5.6.2.1"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the type IA topoisomerase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.6.2.1" evidence="3 7"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51518.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388324.1">
        <property type="nucleotide sequence ID" value="XM_001388287.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPU5"/>
    <dbReference type="STRING" id="353152.A3FPU5"/>
    <dbReference type="GeneID" id="3375949"/>
    <dbReference type="KEGG" id="cpv:cgd6_2390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2390"/>
    <dbReference type="InParanoid" id="A3FPU5"/>
    <dbReference type="OMA" id="EWRIFEY"/>
    <dbReference type="OrthoDB" id="430051at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003917">
        <property type="term" value="F:DNA topoisomerase type I (single strand cut, ATP-independent) activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006310">
        <property type="term" value="P:DNA recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006281">
        <property type="term" value="P:DNA repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006265">
        <property type="term" value="P:DNA topological change"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00186">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd03362">
        <property type="entry name" value="TOPRIM_TopoIA_TopoIII"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.290.10:FF:000001">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.140:FF:000002">
        <property type="entry name" value="DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.140">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.460.10">
        <property type="entry name" value="Topoisomerase I, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.20.10">
        <property type="entry name" value="Topoisomerase I, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.290.10">
        <property type="entry name" value="Topoisomerase I, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000380">
        <property type="entry name" value="Topo_IA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003601">
        <property type="entry name" value="Topo_IA_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023406">
        <property type="entry name" value="Topo_IA_AS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013497">
        <property type="entry name" value="Topo_IA_cen"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013824">
        <property type="entry name" value="Topo_IA_cen_sub1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013825">
        <property type="entry name" value="Topo_IA_cen_sub2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013826">
        <property type="entry name" value="Topo_IA_cen_sub3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023405">
        <property type="entry name" value="Topo_IA_core_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003602">
        <property type="entry name" value="Topo_IA_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006171">
        <property type="entry name" value="TOPRIM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034144">
        <property type="entry name" value="TOPRIM_TopoIII"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR056452">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390:SF20">
        <property type="entry name" value="DNA TOPOISOMERASE 3-BETA-1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11390">
        <property type="entry name" value="PROKARYOTIC DNA TOPOISOMERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01131">
        <property type="entry name" value="Topoisom_bac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01751">
        <property type="entry name" value="Toprim"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23546">
        <property type="entry name" value="Zn_ribbon_TOP3B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00417">
        <property type="entry name" value="PRTPISMRASEI"/>
    </dbReference>
    <dbReference type="SMART" id="SM00437">
        <property type="entry name" value="TOP1Ac"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00436">
        <property type="entry name" value="TOP1Bc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00493">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56712">
        <property type="entry name" value="Prokaryotic type I DNA topoisomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00396">
        <property type="entry name" value="TOPO_IA_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52039">
        <property type="entry name" value="TOPO_IA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50880">
        <property type="entry name" value="TOPRIM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 7" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6 7 10" id="KW-0413">Isomerase</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7" id="KW-0799">Topoisomerase</keyword>
    <feature type="domain" description="Toprim" evidence="8">
        <location>
            <begin position="5"/>
            <end position="145"/>
        </location>
    </feature>
    <feature type="domain" description="Topo IA-type catalytic" evidence="9">
        <location>
            <begin position="167"/>
            <end position="593"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000213"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009446"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00012891"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023029"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU362092"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51518.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="835" mass="95075" checksum="2A74AD00DFF3008F" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="94" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPX9</accession>
    <name>A3FPX9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Putative ABC transporter protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_5350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAZ51552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388358.1">
        <property type="nucleotide sequence ID" value="XM_001388321.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPX9"/>
    <dbReference type="SMR" id="A3FPX9"/>
    <dbReference type="FunCoup" id="A3FPX9">
        <property type="interactions" value="1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FPX9"/>
    <dbReference type="GeneID" id="3375983"/>
    <dbReference type="KEGG" id="cpv:cgd6_5350"/>
    <dbReference type="InParanoid" id="A3FPX9"/>
    <dbReference type="OMA" id="YRLLCWI"/>
    <dbReference type="OrthoDB" id="10255969at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd03213">
        <property type="entry name" value="ABCG_EPDR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013525">
        <property type="entry name" value="ABC2_TM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050352">
        <property type="entry name" value="ABCG_transporters"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041">
        <property type="entry name" value="ABC TRANSPORTER G FAMILY MEMBER 28"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48041:SF139">
        <property type="entry name" value="PROTEIN SCARLET"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01061">
        <property type="entry name" value="ABC2_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="7 8" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="9" id="KW-0732">Signal</keyword>
    <keyword evidence="3 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 8" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="2" id="KW-0813">Transport</keyword>
    <feature type="signal peptide" evidence="9">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5002653042" evidence="9">
        <location>
            <begin position="21"/>
            <end position="782"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="520"/>
            <end position="542"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="562"/>
            <end position="582"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="613"/>
            <end position="632"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="644"/>
            <end position="662"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="674"/>
            <end position="693"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="705"/>
            <end position="725"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="749"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="111"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="782" mass="87365" checksum="EBBC9DCA1A57CC44" modified="2007-04-03" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="98" xmlns="https://uniprot.org/uniprot">
    <accession>A3FPY7</accession>
    <name>A3FPY7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">peptidylprolyl isomerase</fullName>
            <ecNumber evidence="3">5.2.1.8</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd8_2350</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="1 13">
            <text>[protein]-peptidylproline (omega=180) = [protein]-peptidylproline (omega=0)</text>
            <dbReference type="Rhea" id="RHEA:16237"/>
            <dbReference type="Rhea" id="RHEA-COMP:10747"/>
            <dbReference type="Rhea" id="RHEA-COMP:10748"/>
            <dbReference type="ChEBI" id="CHEBI:83833"/>
            <dbReference type="ChEBI" id="CHEBI:83834"/>
            <dbReference type="EC" id="5.2.1.8"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="5.2.1.8" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAZ51468.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388428.1">
        <property type="nucleotide sequence ID" value="XM_001388391.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FPY7"/>
    <dbReference type="STRING" id="353152.A3FPY7"/>
    <dbReference type="GeneID" id="3374647"/>
    <dbReference type="KEGG" id="cpv:cgd8_2350"/>
    <dbReference type="InParanoid" id="A3FPY7"/>
    <dbReference type="OMA" id="APKCCEN"/>
    <dbReference type="OrthoDB" id="2083at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003755">
        <property type="term" value="F:peptidyl-prolyl cis-trans isomerase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="CDD" id="cd12235">
        <property type="entry name" value="RRM_PPIL4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.100.10">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035542">
        <property type="entry name" value="CRIP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029000">
        <property type="entry name" value="Cyclophilin-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002130">
        <property type="entry name" value="Cyclophilin-type_PPIase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45843:SF1">
        <property type="entry name" value="PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-LIKE 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00160">
        <property type="entry name" value="Pro_isomerase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00153">
        <property type="entry name" value="CSAPPISMRASE"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50891">
        <property type="entry name" value="Cyclophilin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50072">
        <property type="entry name" value="CSA_PPIASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0413">Isomerase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 8" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="5" id="KW-0697">Rotamase</keyword>
    <feature type="domain" description="PPIase cyclophilin-type" evidence="9">
        <location>
            <begin position="6"/>
            <end position="162"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="232"/>
            <end position="302"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000971"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023110"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50072"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAZ51468.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="302" mass="34551" checksum="1986F44D52CA493F" modified="2007-04-03" version="1">MSVLIETTLGDLVIDLNVDLCPKTCENFLKLCKLKFYNNCEFYKIEKDFIARTGRSKQYGNSSLYQLLSNQKKDNISLELETTPKLKHKRMGVLGMVNHISKNSLGSEFYFTLKDELSHLDGNHVIFAQVEEGIPILSKLNQVITDENSIPLQKVMILHTYILDDPFEDSPQLLEIIPPNSPPEETDPLVQTYDQDEVKALNSISEREAKSRAITLEILGDIPDADMKPPENVLFVCKLNPVTQDDDLELIFSRFGEVKSCNIIRDYKTGDSLQYAFIEFETKQQCEMAFLKMQNAVIDDRR</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQ17</accession>
    <name>A3FQ17_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="10">Rhomboid-like protease</fullName>
            <ecNumber evidence="10">3.4.21.105</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd3_980</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="10">Serine protease involved in intramembrane proteolysis.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="1 10">
            <text>Cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine that are contributed by different transmembrane domains.</text>
            <dbReference type="EC" id="3.4.21.105"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2 10">Membrane</location>
            <topology evidence="2 10">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 10">Belongs to the peptidase S54 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">Lacks conserved residue(s) required for the propagation of feature annotation.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.4.21.105" evidence="10"/>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAZ51425.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388097.1">
        <property type="nucleotide sequence ID" value="XM_001388060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQ17"/>
    <dbReference type="SMR" id="A3FQ17"/>
    <dbReference type="STRING" id="353152.A3FQ17"/>
    <dbReference type="MEROPS" id="S54.021"/>
    <dbReference type="GeneID" id="3373943"/>
    <dbReference type="KEGG" id="cpv:cgd3_980"/>
    <dbReference type="InParanoid" id="A3FQ17"/>
    <dbReference type="OMA" id="ASIWHIV"/>
    <dbReference type="OrthoDB" id="418595at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004252">
        <property type="term" value="F:serine-type endopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1540.10">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002610">
        <property type="entry name" value="Peptidase_S54_rhomboid-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR022764">
        <property type="entry name" value="Peptidase_S54_rhomboid_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035952">
        <property type="entry name" value="Rhomboid-like_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936:SF69">
        <property type="entry name" value="RHOMBOID-LIKE PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR22936">
        <property type="entry name" value="RHOMBOID-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01694">
        <property type="entry name" value="Rhomboid"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF144091">
        <property type="entry name" value="Rhomboid-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 10" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="9 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="4 10" id="KW-0645">Protease</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 10" id="KW-0720">Serine protease</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="8 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="22"/>
            <end position="44"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="56"/>
            <end position="79"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="85"/>
            <end position="108"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="117"/>
            <end position="136"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="142"/>
            <end position="161"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="173"/>
            <end position="194"/>
        </location>
    </feature>
    <feature type="domain" description="Peptidase S54 rhomboid" evidence="11">
        <location>
            <begin position="20"/>
            <end position="158"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="12">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00000156"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00009045"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022670"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022825"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="RuleBase" id="RU362115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF01694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAZ51425.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="210" mass="23238" checksum="49BD3771D87364F0" modified="2007-04-03" version="1" fragment="single">PFRTTLIKFQASVPSLVKEGQVWRLLVSLFLHASIWHIVFNIIFQIRLSLSCEVKYGRILNFTIYFISGLLGNLFSVAIRSSCVVAVGASTSGFGLIGAQLAELILFWHTLQNKEQVVINILLFGILMILITWGNPSSAIDHWGHIGGFVSGTCLGIICNFKSDLKPKWYKAAFGVSIALISSTLIGPIIRIWAFELAPCVVFPEKLMNP</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="85" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQC6</accession>
    <name>A3FQC6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">RNA helicase</fullName>
            <ecNumber evidence="1">3.6.4.13</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd1_880</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>ATP + H2O = ADP + phosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:13065"/>
            <dbReference type="ChEBI" id="CHEBI:15377"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:43474"/>
            <dbReference type="ChEBI" id="CHEBI:456216"/>
            <dbReference type="EC" id="3.6.4.13"/>
        </reaction>
    </comment>
    <comment type="similarity">
        <text evidence="9">Belongs to the DEAD box helicase family. eIF4A subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="3.6.4.13" evidence="1"/>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAZ51325.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388148.1">
        <property type="nucleotide sequence ID" value="XM_001388111.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQC6"/>
    <dbReference type="SMR" id="A3FQC6"/>
    <dbReference type="FunCoup" id="A3FQC6">
        <property type="interactions" value="338"/>
    </dbReference>
    <dbReference type="STRING" id="353152.A3FQC6"/>
    <dbReference type="GeneID" id="3371494"/>
    <dbReference type="KEGG" id="cpv:cgd1_880"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_880"/>
    <dbReference type="InParanoid" id="A3FQC6"/>
    <dbReference type="OMA" id="FGCQALV"/>
    <dbReference type="OrthoDB" id="10265785at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003724">
        <property type="term" value="F:RNA helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003743">
        <property type="term" value="F:translation initiation factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd18046">
        <property type="entry name" value="DEADc_EIF4AII_EIF4AI_DDX2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd18787">
        <property type="entry name" value="SF2_C_DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000089">
        <property type="entry name" value="Eukaryotic initiation factor 4A-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000031">
        <property type="entry name" value="Eukaryotic initiation factor 4A-III"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044728">
        <property type="entry name" value="EIF4A_DEADc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000629">
        <property type="entry name" value="RNA-helicase_DEAD-box_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014014">
        <property type="entry name" value="RNA_helicase_DEAD_Q_motif"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47958">
        <property type="entry name" value="ATP-DEPENDENT RNA HELICASE DBP3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00039">
        <property type="entry name" value="DEAD_ATP_HELICASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51195">
        <property type="entry name" value="Q_MOTIF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 12" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5 12" id="KW-0347">Helicase</keyword>
    <keyword evidence="4 12" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2 16" id="KW-0396">Initiation factor</keyword>
    <keyword evidence="3 12" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="DEAD-box RNA helicase Q" evidence="15">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="13">
        <location>
            <begin position="62"/>
            <end position="232"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="14">
        <location>
            <begin position="243"/>
            <end position="404"/>
        </location>
    </feature>
    <feature type="short sequence motif" description="Q motif" evidence="11">
        <location>
            <begin position="31"/>
            <end position="59"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00012552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00024352"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047984"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="RuleBase" id="RU000492"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="13">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51195"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAZ51325.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="405" mass="45934" checksum="BD1E558048C6B79A" modified="2007-04-03" version="1">MTNSEQNPPSEENVQVASTGEIESNYDEIVECFEALNLEGDLLRGIFAYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVIAALQKIDYSLNACQVLLLAPTRELAQQIQKVALALGDYCELRCHACVGGTSVRDDMNKLKSGVHMVVGTPGRVFDMLDKGYLRVDNLKLFILDEADEMLSRGFKVQIHDIFKKLPQDVQVALFSATMPNEILHLTTQFMRDPKRILVKQEELTLEGIRQFYVGVEKDEWKMDTLIDLYETLTIVQAIIYCNTRRRVDQLTKQMRERDFTCSSMHGDMDQKDREVIMRQFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPVSPETYIHRIGRSGRFGKKGVSINFVTDDDIVCLRDIERHYNTQIEEMPMGITDILQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="91" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQG5</accession>
    <name>A3FQG5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="9">Serine/threonine kinase-1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="9" type="ORF">cgd5_250</name>
    </gene>
    <organism evidence="9 10">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="9 10" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="10">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="9">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388249.1">
        <property type="nucleotide sequence ID" value="XM_001388212.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQG5"/>
    <dbReference type="STRING" id="353152.A3FQG5"/>
    <dbReference type="GeneID" id="3373032"/>
    <dbReference type="KEGG" id="cpv:cgd5_250"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_250"/>
    <dbReference type="InParanoid" id="A3FQG5"/>
    <dbReference type="OMA" id="SDECRSD"/>
    <dbReference type="OrthoDB" id="283111at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004674">
        <property type="term" value="F:protein serine/threonine kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd14134">
        <property type="entry name" value="PKc_CLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051175">
        <property type="entry name" value="CLK_kinases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE DOA-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45646:SF11">
        <property type="entry name" value="SERINE_THREONINE-PROTEIN KINASE DOA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5 6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="4 9" id="KW-0418">Kinase</keyword>
    <keyword evidence="3 6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="10" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0723">Serine/threonine-protein kinase</keyword>
    <keyword evidence="2" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="8">
        <location>
            <begin position="306"/>
            <end position="644"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="255"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="7">
        <location>
            <begin position="258"/>
            <end position="287"/>
        </location>
    </feature>
    <feature type="binding site" evidence="6">
        <location>
            <position position="335"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022527"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="8">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="EMBL" id="EAZ51271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="652" mass="77200" checksum="969419B2E3F7AD53" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQK0</accession>
    <name>A3FQK0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">RNA recognition motif (RRM)-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_3270</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAZ51306.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388284.1">
        <property type="nucleotide sequence ID" value="XM_001388247.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQK0"/>
    <dbReference type="STRING" id="353152.A3FQK0"/>
    <dbReference type="GeneID" id="3373330"/>
    <dbReference type="KEGG" id="cpv:cgd5_3270"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3270"/>
    <dbReference type="InParanoid" id="A3FQK0"/>
    <dbReference type="OMA" id="MRDPDGR"/>
    <dbReference type="OrthoDB" id="1875751at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003729">
        <property type="term" value="F:mRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006417">
        <property type="term" value="P:regulation of translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032:SF6">
        <property type="entry name" value="RNA-BINDING (RRM_RBD_RNP MOTIFS) FAMILY PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR48032">
        <property type="entry name" value="RNA-BINDING PROTEIN MUSASHI HOMOLOG RBP6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 3" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="8"/>
            <end position="85"/>
        </location>
    </feature>
    <feature type="domain" description="RRM" evidence="4">
        <location>
            <begin position="121"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAZ51306.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="202" mass="22857" checksum="A6F18ED42960EC8F" modified="2007-04-03" version="1">MTMNLESGKIFVGGLSQQVTSSILMEYFLQFGVILDAVVMYDNVSGRSRGFGFVTFKDPKTVEIVQNITPHIIMGKVVDCKRASPRNTNLMIKEYFEDITKNENTPENYNNAVTKGIKNVSKIFVGGLPDLTLEEFKIYFQRFGNIKDAVLITDKNNGRPRGFGFVTFESVDAVNNVTKFYSNHYLKGKWVECKRALPRDGI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="57" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQM5</accession>
    <name>A3FQM5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="1">Rab-GAP TBC domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_3900</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAZ51268.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388080.1">
        <property type="nucleotide sequence ID" value="XM_001388043.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQM5"/>
    <dbReference type="STRING" id="353152.A3FQM5"/>
    <dbReference type="GeneID" id="3372770"/>
    <dbReference type="KEGG" id="cpv:cgd4_3900"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3900"/>
    <dbReference type="InParanoid" id="A3FQM5"/>
    <dbReference type="OMA" id="VWDIFII"/>
    <dbReference type="OrthoDB" id="295078at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="1">
        <location>
            <begin position="1"/>
            <end position="163"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAZ51268.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="323" mass="38598" checksum="AD86B3E4536DEC3A" modified="2007-04-03" version="1">MLNNHDEILRDISRTFPKLKEFQINENQNKMIEILFKISYALPNVGYCQGMNYLVGIFLYALDFNVEQVYSSVMSILINWEYQEIYNKGLIKLREMCFVFNELIKEYLPEIYDNIFNNKENEIEITSELFAIQWFLTLFTYDIADTEYAINSILILDNIIIHDPSKNFNITVYKIALSLLCIIFKDYKFEKFNLNTHILEFVRNRSKEILMNINEIDTLLNMSRDLKVSEYIIQKIYIKYKNLELNTNFNTSNNGFKDEDADQDQDEINIEKEIQKSSMINNIFNNSKFQEFSSSHLLKRYIVISRFEDMDEFPSSFHPYFNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>A3FQP0</accession>
    <name>A3FQP0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Regulator of chromosome condensation</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd4_1350</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAZ51246.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_001388058.1">
        <property type="nucleotide sequence ID" value="XM_001388021.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="A3FQP0"/>
    <dbReference type="STRING" id="353152.A3FQP0"/>
    <dbReference type="GeneID" id="3372621"/>
    <dbReference type="KEGG" id="cpv:cgd4_1350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1350"/>
    <dbReference type="InParanoid" id="A3FQP0"/>
    <dbReference type="OMA" id="CCEGPKP"/>
    <dbReference type="OrthoDB" id="61110at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005085">
        <property type="term" value="F:guanyl-nucleotide exchange factor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.30">
        <property type="entry name" value="Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="4.10.1060.10">
        <property type="entry name" value="Zinc finger, RanBP2-type"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051553">
        <property type="entry name" value="Ran_GTPase-activating"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR058923">
        <property type="entry name" value="RCC1-like_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009091">
        <property type="entry name" value="RCC1/BLIP-II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000408">
        <property type="entry name" value="Reg_chr_condens"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001876">
        <property type="entry name" value="Znf_RanBP2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR45982:SF1">
        <property type="entry name" value="REGULATOR OF CHROMOSOME CONDENSATION"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF25390">
        <property type="entry name" value="WD40_RLD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00633">
        <property type="entry name" value="RCCNDNSATION"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50985">
        <property type="entry name" value="RCC1/BLIP-II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50012">
        <property type="entry name" value="RCC1_3"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01358">
        <property type="entry name" value="ZF_RANBP2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50199">
        <property type="entry name" value="ZF_RANBP2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0344">Guanine-nucleotide releasing factor</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="5" id="KW-0862">Zinc</keyword>
    <keyword evidence="4 7" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RanBP2-type" evidence="9">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="143"/>
            <end position="200"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="301"/>
            <end position="389"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="390"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="repeat" description="RCC1" evidence="6">
        <location>
            <begin position="594"/>
            <end position="657"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="231"/>
            <end position="270"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="667"/>
            <end position="958"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="231"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="242"/>
            <end position="265"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="667"/>
            <end position="677"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="678"/>
            <end position="696"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="8">
        <location>
            <begin position="697"/>
            <end position="736"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="753"/>
            <end position="770"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="785"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="827"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="878"/>
            <end position="896"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="912"/>
            <end position="928"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="8">
        <location>
            <begin position="936"/>
            <end position="949"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00322"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS50199"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAZ51246.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="958" mass="107941" checksum="1B13652C5421A67B" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPF0</accession>
    <name>Q5CPF0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_5480</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000016">
        <property type="protein sequence ID" value="EAK87301.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_625312.1"/>
    </dbReference>
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    <dbReference type="STRING" id="353152.Q5CPF0"/>
    <dbReference type="GeneID" id="3375630"/>
    <dbReference type="KEGG" id="cpv:cgd6_5480"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5480"/>
    <dbReference type="InParanoid" id="Q5CPF0"/>
    <dbReference type="OrthoDB" id="10589226at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
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        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
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        <location>
            <begin position="24"/>
            <end position="229"/>
        </location>
    </feature>
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        <location>
            <begin position="40"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="120"/>
            <end position="229"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="42"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="143"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="165"/>
            <end position="188"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="189"/>
            <end position="209"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87301.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="229" mass="26689" checksum="D283E41EEA7841AA" modified="2005-04-12" version="1">MFIKSKILLLFIYFMFLFENVTDDFLVKKEISLIKIRNEIPNEGSSSSGNNNSEGLSRGRKKPVLRSMRTLSLEGFEKSSHCHHPHKKKHCHDKKQNIAYQYIPGESSGKKVIFHVPTLKMKDPDDPEQNPSDMPSDEPHNSDDEESCDDEDADEQPCDDEKEEEEKYQKEKEKEEMENKHDQVDSGRKRQHKRKIRKNKNNSRPRGSGKHFSEKICGPCKNINMEDLE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPH6</accession>
    <name>Q5CPH6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_20</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87328.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625317.1">
        <property type="nucleotide sequence ID" value="XM_625317.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPH6"/>
    <dbReference type="GeneID" id="3372324"/>
    <dbReference type="KEGG" id="cpv:cgd3_20"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_20"/>
    <dbReference type="InParanoid" id="Q5CPH6"/>
    <dbReference type="OMA" id="ANWNYIT"/>
    <dbReference type="OrthoDB" id="343932at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254780" evidence="2">
        <location>
            <begin position="24"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="37"/>
            <end position="56"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="40"/>
            <end position="51"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87328.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="376" mass="43199" checksum="6E597943BF8B7C23" modified="2005-04-12" version="1">MRLRIKVYLIFLVGIFTTKICSSLTIKEIEAIGNNDHSRTNSSFTTDSELISSDEDSNLTDDQTILKSYSSSKDQSLYSNSQIIEYDDVSGNLGIIAIITNKRQTCRIISGNFNKRNETKNTLYLLFDTTNKNFVSIFVPRLIDFTLKGKQGLVTLIYNEEIFLLNKLLLINSNGEISTTKHPWKLVIEVNSDYNKLQSLPYDLRNKHYIKLPPDGWDANDDSVYPKNIKSIKPLSILSKNMNQIKELRIPHFSVGVIPTALFLKLNTGEYMSIIVPNNTVFFVDIDDCSIHSKDGHYYNICGGYSVYCNRWLFTNRPWKSRIIIQSNFEELLVITKSKLQVLENVEQLSNTSKITENFRNNIKNNKCGKYFCSRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="47" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPI0</accession>
    <name>Q5CPI0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_330</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000014">
        <property type="protein sequence ID" value="EAK87360.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625369.1">
        <property type="nucleotide sequence ID" value="XM_625369.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPI0"/>
    <dbReference type="STRING" id="353152.Q5CPI0"/>
    <dbReference type="GeneID" id="3375655"/>
    <dbReference type="KEGG" id="cpv:cgd6_330"/>
    <dbReference type="InParanoid" id="Q5CPI0"/>
    <dbReference type="OMA" id="NSKWWIS"/>
    <dbReference type="OrthoDB" id="1259151at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031490">
        <property type="term" value="F:chromatin DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003713">
        <property type="term" value="F:transcription coactivator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd13214">
        <property type="entry name" value="PH-GRAM_WBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044852">
        <property type="entry name" value="WBP2-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR31606:SF1">
        <property type="entry name" value="WW DOMAIN BINDING PROTEIN 2, ISOFORM E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50729">
        <property type="entry name" value="PH domain-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87360.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="174" mass="20039" checksum="6A1608B979237A46" modified="2005-04-12" version="1" fragment="single">CRLIQNFSILEKQVILFQIDKHIKNYINLNLNLGELIPSLLRDEYMLMSRKSVKFGLDDVNERFKGHGDVFVTNKRVILIRSKLSTNALSNFVSLCIPLKNVYNLEFKQPVLLASYLEGFVKPCNNSTYPLSGNSKWWISFHKGGCATFVRSFYKIYLKATKDSITEEDLGGKY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPL9</accession>
    <name>Q5CPL9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Signal peptide, large protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_340</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625402.1">
        <property type="nucleotide sequence ID" value="XM_625402.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPL9"/>
    <dbReference type="STRING" id="353152.Q5CPL9"/>
    <dbReference type="GeneID" id="3372384"/>
    <dbReference type="KEGG" id="cpv:cgd2_340"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_340"/>
    <dbReference type="InParanoid" id="Q5CPL9"/>
    <dbReference type="OrthoDB" id="338308at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253717" evidence="2">
        <location>
            <begin position="24"/>
            <end position="1236"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="312"/>
            <end position="339"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="955"/>
            <end position="982"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="1130"/>
            <end position="1185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1236" mass="148055" checksum="946ABA61B4231763" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="108" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPP4</accession>
    <name>Q5CPP4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">ABC transporter, with 12 x transmembrane domains and 2x AAA domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd2_70</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000013">
        <property type="protein sequence ID" value="EAK87389.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625377.1">
        <property type="nucleotide sequence ID" value="XM_625377.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CPP4">
        <property type="interactions" value="3"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPP4"/>
    <dbReference type="GeneID" id="3372373"/>
    <dbReference type="KEGG" id="cpv:cgd2_70"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_70"/>
    <dbReference type="InParanoid" id="Q5CPP4"/>
    <dbReference type="OMA" id="HINTDCE"/>
    <dbReference type="OrthoDB" id="4865934at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140359">
        <property type="term" value="F:ABC-type transporter activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.1560.10">
        <property type="entry name" value="ABC transporter type 1, transmembrane domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011527">
        <property type="entry name" value="ABC1_TM_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036640">
        <property type="entry name" value="ABC1_TM_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003439">
        <property type="entry name" value="ABC_transporter-like_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017871">
        <property type="entry name" value="ABC_transporter-like_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050173">
        <property type="entry name" value="ABC_transporter_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223">
        <property type="entry name" value="ATP-BINDING CASSETTE SUB-FAMILY C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24223:SF456">
        <property type="entry name" value="MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN LETHAL(2)03659"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00664">
        <property type="entry name" value="ABC_membrane"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00005">
        <property type="entry name" value="ABC_tran"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90123">
        <property type="entry name" value="ABC transporter transmembrane region"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50929">
        <property type="entry name" value="ABC_TM1F"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00211">
        <property type="entry name" value="ABC_TRANSPORTER_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50893">
        <property type="entry name" value="ABC_TRANSPORTER_2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="8 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 9 12" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 9" id="KW-1133">Transmembrane helix</keyword>
    <keyword evidence="3" id="KW-0813">Transport</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="89"/>
            <end position="109"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="115"/>
            <end position="135"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="227"/>
            <end position="249"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="261"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="348"/>
            <end position="367"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="954"/>
            <end position="979"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1000"/>
            <end position="1025"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1045"/>
            <end position="1063"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1075"/>
            <end position="1094"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="1100"/>
            <end position="1119"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="88"/>
            <end position="344"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="568"/>
            <end position="819"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transmembrane type-1" evidence="11">
        <location>
            <begin position="974"/>
            <end position="1210"/>
        </location>
    </feature>
    <feature type="domain" description="ABC transporter" evidence="10">
        <location>
            <begin position="1307"/>
            <end position="1587"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009726"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022448"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50893"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="PROSITE" id="PS50929"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK87389.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1587" mass="180645" checksum="CE6B931668392A55" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="103" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPQ8</accession>
    <name>Q5CPQ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">2x PHD domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_4410</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
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    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87407.1"/>
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    </dbReference>
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        <property type="nucleotide sequence ID" value="XM_625456.1"/>
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    <dbReference type="KEGG" id="cpv:cgd4_4410"/>
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        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
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        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
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        <property type="entry name" value="PHRF1/Atg35"/>
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    </dbReference>
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        <property type="entry name" value="Znf_C3HC4_RING-type"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011011">
        <property type="entry name" value="Znf_FYVE_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001965">
        <property type="entry name" value="Znf_PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019787">
        <property type="entry name" value="Znf_PHD-finger"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001841">
        <property type="entry name" value="Znf_RING"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017907">
        <property type="entry name" value="Znf_RING_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
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    </dbReference>
    <dbReference type="PANTHER" id="PTHR12618:SF20">
        <property type="entry name" value="PHD AND RING FINGER DOMAIN-CONTAINING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00628">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00097">
        <property type="entry name" value="zf-C3HC4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00249">
        <property type="entry name" value="PHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00184">
        <property type="entry name" value="RING"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57903">
        <property type="entry name" value="FYVE/PHD zinc finger"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01359">
        <property type="entry name" value="ZF_PHD_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50016">
        <property type="entry name" value="ZF_PHD_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00518">
        <property type="entry name" value="ZF_RING_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50089">
        <property type="entry name" value="ZF_RING_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2 4" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-type" evidence="7">
        <location>
            <begin position="188"/>
            <end position="227"/>
        </location>
    </feature>
    <feature type="domain" description="PHD-type" evidence="6">
        <location>
            <begin position="269"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="364"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="468"/>
            <end position="527"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="564"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="712"/>
            <end position="738"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="779"/>
            <end position="816"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="900"/>
            <end position="933"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="367"/>
            <end position="393"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="403"/>
            <end position="414"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="473"/>
            <end position="490"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="5">
        <location>
            <begin position="496"/>
            <end position="505"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="506"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="564"/>
            <end position="588"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="5">
        <location>
            <begin position="720"/>
            <end position="733"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="780"/>
            <end position="791"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="5">
        <location>
            <begin position="801"/>
            <end position="812"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="911"/>
            <end position="925"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00175"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS50016"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50089"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87407.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="933" mass="104308" checksum="DEE277A031FA445A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPR4</accession>
    <name>Q5CPR4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">START domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd4_4350</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000012">
        <property type="protein sequence ID" value="EAK87415.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625450.1">
        <property type="nucleotide sequence ID" value="XM_625450.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPR4"/>
    <dbReference type="GeneID" id="3372389"/>
    <dbReference type="KEGG" id="cpv:cgd4_4350"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_4350"/>
    <dbReference type="InParanoid" id="Q5CPR4"/>
    <dbReference type="OMA" id="DICKYNI"/>
    <dbReference type="OrthoDB" id="341780at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87415.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="846" mass="96254" checksum="9509E5636EEC016A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="97" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPW7</accession>
    <name>Q5CPW7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Pus1p-like type II pseudousynthas TruA</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_510</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the tRNA pseudouridine synthase TruA family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87494.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625512.1">
        <property type="nucleotide sequence ID" value="XM_625512.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPW7"/>
    <dbReference type="FunCoup" id="Q5CPW7">
        <property type="interactions" value="185"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPW7"/>
    <dbReference type="GeneID" id="3372456"/>
    <dbReference type="KEGG" id="cpv:cgd8_510"/>
    <dbReference type="InParanoid" id="Q5CPW7"/>
    <dbReference type="OMA" id="NKAFDCR"/>
    <dbReference type="OrthoDB" id="10256309at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0009982">
        <property type="term" value="F:pseudouridine synthase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990481">
        <property type="term" value="P:mRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031119">
        <property type="term" value="P:tRNA pseudouridine synthesis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd02568">
        <property type="entry name" value="PseudoU_synth_PUS1_PUS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.660:FF:000002">
        <property type="entry name" value="tRNA pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.660">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, C-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.580">
        <property type="entry name" value="Pseudouridine synthase I, catalytic domain, N-terminal subdomain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00171">
        <property type="entry name" value="TruA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020103">
        <property type="entry name" value="PsdUridine_synth_cat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001406">
        <property type="entry name" value="PsdUridine_synth_TruA"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020097">
        <property type="entry name" value="PsdUridine_synth_TruA_a/b_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020095">
        <property type="entry name" value="PsdUridine_synth_TruA_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR041708">
        <property type="entry name" value="PUS1/PUS2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020094">
        <property type="entry name" value="TruA/RsuA/RluB/E/F_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11142:SF4">
        <property type="entry name" value="PSEUDOURIDYLATE SYNTHASE 1 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01416">
        <property type="entry name" value="PseudoU_synth_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55120">
        <property type="entry name" value="Pseudouridine synthase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0413">Isomerase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="Pseudouridine synthase I TruA alpha/beta" evidence="7">
        <location>
            <begin position="338"/>
            <end position="445"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="246"/>
            <end position="283"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="6">
        <location>
            <begin position="265"/>
            <end position="281"/>
        </location>
    </feature>
    <feature type="active site" description="Nucleophile" evidence="4">
        <location>
            <position position="80"/>
        </location>
    </feature>
    <feature type="binding site" evidence="5">
        <location>
            <position position="204"/>
        </location>
        <ligand>
            <name>substrate</name>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009375"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023235"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PIRSR" id="PIRSR641708-2"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="Pfam" id="PF01416"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87494.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="501" mass="58810" checksum="C02DB594531A679E" modified="2005-04-12" version="1">MKEVIPMKTYCMSFGYDGSDYHGMQIQMRNNKKVEELRTIEGEMEDCLEKLGMFFLSNEQNDDQGGLLKKIKWSRVGRTDKGVHSVCQVVSFRAKIKINDELELILKNKDVDEKIIEICKRLKEERDILNKNGVDKIQSINPLLGGASLVLKNNLDEFLDELLILDYIVTKLNELLESTKIKVFKIFRVTKNFDARTDCSRRQYEYLMPEFLLKHVNINNDDFKEELNKASLSRFEKGLNELKNASKKRKRETINTSLNHNPEVNEIEEEVEREEDDEDDEKGERMKQFEFHQTNRLNNYGFGNDYRLVNYKIEDYLDPKRRFSLSDEDLKRFQSILNEYIGTHSFHNFTSKSSYEDSTSWRHIEEIKVVKVSQNEIKGEINLIKIIIKGQSFLLHQIRKMVALAIEIFRGTAPSNGIQLCFLPDKFSIHLAPSQGLLLDRVFYNSYNTKRSISTDQTDFAIQFLSFHIKDCHFVKEMESFKVNSIYSKIYSTISEENYNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ01</accession>
    <name>Q5CQ01_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_140</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Iowa type II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87467.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625478.1">
        <property type="nucleotide sequence ID" value="XM_625478.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ01"/>
    <dbReference type="GeneID" id="3372497"/>
    <dbReference type="KEGG" id="cpv:cgd8_140"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_140"/>
    <dbReference type="InParanoid" id="Q5CQ01"/>
    <dbReference type="OrthoDB" id="337927at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="863"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1034"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="865"/>
            <end position="882"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="989"/>
            <end position="1006"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1014"/>
            <end position="1034"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87467.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1061" mass="117018" checksum="10674DB81B0FE423" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ14</accession>
    <name>Q5CQ14_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_10</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000011">
        <property type="protein sequence ID" value="EAK87454.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625465.1">
        <property type="nucleotide sequence ID" value="XM_625465.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ14"/>
    <dbReference type="STRING" id="353152.Q5CQ14"/>
    <dbReference type="GeneID" id="3372484"/>
    <dbReference type="KEGG" id="cpv:cgd8_10"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_10"/>
    <dbReference type="InParanoid" id="Q5CQ14"/>
    <dbReference type="OrthoDB" id="339137at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87454.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="290" mass="33196" checksum="EC36DE7F81090688" modified="2005-04-12" version="1">MSSTSRNPGPGGEIRPIPSFPMFDEERGNREFLVVTIEKEMEISVPFLANYETAVDAGKFKRLIAYEHKADMYHIVKIENQTSDVQIFNENGKLKFVFSTHVFGINTEKILEKMSGYQDDLNKVVVEEFPFENIPNKPQYYNRGYKILIPENFDVFRDQQYIEVTGQDGVEFKGIFSLDQPELKLPTEHTGDTYEFYTTSGTYAVFRGYENKRIYAIPVLEKVKCYVDTNYGRVRMANVCNLTFNVNYGILSVGEMEINTVNICGKRAIIGNTIEEVINIGISRLNEGSD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ28</accession>
    <name>Q5CQ28_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Large protein with possible RING domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd5_4360</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87583.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625598.1">
        <property type="nucleotide sequence ID" value="XM_625598.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQ28"/>
    <dbReference type="GeneID" id="3372582"/>
    <dbReference type="KEGG" id="cpv:cgd5_4360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4360"/>
    <dbReference type="InParanoid" id="Q5CQ28"/>
    <dbReference type="OMA" id="NNTHICR"/>
    <dbReference type="OrthoDB" id="342597at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="152"/>
            <end position="185"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="458"/>
            <end position="491"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="778"/>
            <end position="875"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1099"/>
            <end position="1135"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1279"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1301"/>
            <end position="1364"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="167"/>
            <end position="178"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="461"/>
            <end position="470"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="471"/>
            <end position="486"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="778"/>
            <end position="788"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="789"/>
            <end position="810"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="827"/>
            <end position="861"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="862"/>
            <end position="872"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1252"/>
            <end position="1261"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="1341"/>
            <end position="1350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="1351"/>
            <end position="1364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87583.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1364" mass="153083" checksum="6A6CFA7A60ED5441" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQ52</accession>
    <name>Q5CQ52_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Possible EF hand protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_4110</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000010">
        <property type="protein sequence ID" value="EAK87559.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625574.1">
        <property type="nucleotide sequence ID" value="XM_625574.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQ52"/>
    <dbReference type="SMR" id="Q5CQ52"/>
    <dbReference type="GeneID" id="3372526"/>
    <dbReference type="KEGG" id="cpv:cgd5_4110"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_4110"/>
    <dbReference type="InParanoid" id="Q5CQ52"/>
    <dbReference type="OMA" id="LEWNFIP"/>
    <dbReference type="OrthoDB" id="264015at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.238.10">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011992">
        <property type="entry name" value="EF-hand-dom_pair"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47473">
        <property type="entry name" value="EF-hand"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87559.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="182" mass="20815" checksum="2FF96B5FF90F6832" modified="2005-04-12" version="1">MNPSTQNSSASLRADGQTVSFGQRKVWDNERDLPDVVKLLDREYKDVIPFTDIQNRMMEWNFIPREHIAEACDTLKSLCDSQGNISLHILIDQLTGFPEASEKDDMDANIDTLEAYKIFDHNNKGCIDLESLRKISNELGEELDDETLTGMLNLATQDVFRKQQNIISRDDFFSLVKSKVLN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQH2</accession>
    <name>Q5CQH2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Putative nucleosome assembly protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_720</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the nucleosome assembly protein (NAP) family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87723.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625676.1">
        <property type="nucleotide sequence ID" value="XM_625676.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQH2"/>
    <dbReference type="FunCoup" id="Q5CQH2">
        <property type="interactions" value="235"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQH2"/>
    <dbReference type="GeneID" id="3372654"/>
    <dbReference type="KEGG" id="cpv:cgd4_720"/>
    <dbReference type="InParanoid" id="Q5CQH2"/>
    <dbReference type="OMA" id="AAECKQN"/>
    <dbReference type="OrthoDB" id="27325at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006334">
        <property type="term" value="P:nucleosome assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.1500">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1120.90">
        <property type="entry name" value="Nucleosome assembly protein"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037231">
        <property type="entry name" value="NAP-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002164">
        <property type="entry name" value="NAP_family"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11875">
        <property type="entry name" value="TESTIS-SPECIFIC Y-ENCODED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00956">
        <property type="entry name" value="NAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF143113">
        <property type="entry name" value="NAP-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="3">
        <location>
            <begin position="280"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="3">
        <location>
            <begin position="280"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="3">
        <location>
            <begin position="336"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009947"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU003876"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87723.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="347" mass="40460" checksum="154180C6D0DB2FE2" modified="2005-04-12" version="1" fragment="single">LHLIQISSAYKKVKMNTNTSGDKIEEIDEFEQHLSDESRQSLKKLKDLQIEFNLIEKEYLAEMRKLRSKFEAQYNEIYSKRDQILESGTVEESGTPGLPQFWITAMRNSRMLGSAIEEYDIPILSYLKNITSEWTSEQQSGFILNFNFAPNPFFEGTNIKKEYVMVFLEDDEPLLSNTVVSKIEWKQGRDPTQEVVVRRQRHKQSKEVRIVTETVHRESFFNFFKSLNVPSDEELAKMDRFDIMELESTVETDYEMGIFIRDKLIPYSLYWFTGEAVDEDDELEEDDEGDILNVDEDESDSESESSSESNSDTDSDSEDDRSNKISNRSNKKNLFGNMSNAKSFKRN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQQ1</accession>
    <name>Q5CQQ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_3750</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87752.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625951.1">
        <property type="nucleotide sequence ID" value="XM_625951.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQQ1"/>
    <dbReference type="SMR" id="Q5CQQ1"/>
    <dbReference type="GeneID" id="3372799"/>
    <dbReference type="KEGG" id="cpv:cgd4_3750"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_3750"/>
    <dbReference type="InParanoid" id="Q5CQQ1"/>
    <dbReference type="OrthoDB" id="343276at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="18"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253749" evidence="2">
        <location>
            <begin position="19"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="411"/>
            <end position="646"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="413"/>
            <end position="452"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="1">
        <location>
            <begin position="456"/>
            <end position="485"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="498"/>
            <end position="510"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="520"/>
            <end position="531"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="556"/>
            <end position="569"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="579"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="617"/>
            <end position="639"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87752.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="646" mass="73093" checksum="2617B0F8440E2309" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="110" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQU9</accession>
    <name>Q5CQU9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Histone H3</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd4_3220</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subunit">
        <text evidence="8">The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Chromosome</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 8">Belongs to the histone H3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87921.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625903.1">
        <property type="nucleotide sequence ID" value="XM_625903.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQU9"/>
    <dbReference type="FunCoup" id="Q5CQU9">
        <property type="interactions" value="234"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQU9"/>
    <dbReference type="GeneID" id="3372937"/>
    <dbReference type="KEGG" id="cpv:cgd4_3220"/>
    <dbReference type="InParanoid" id="Q5CQU9"/>
    <dbReference type="OMA" id="HIFAEMA"/>
    <dbReference type="OrthoDB" id="4025405at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005654">
        <property type="term" value="C:nucleoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000786">
        <property type="term" value="C:nucleosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046982">
        <property type="term" value="F:protein heterodimerization activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030527">
        <property type="term" value="F:structural constituent of chromatin"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd22911">
        <property type="entry name" value="HFD_H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.20.10:FF:000001">
        <property type="entry name" value="Histone H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.20.10">
        <property type="entry name" value="Histone, subunit A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007125">
        <property type="entry name" value="H2A/H2B/H3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009072">
        <property type="entry name" value="Histone-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000164">
        <property type="entry name" value="Histone_H3/CENP-A"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11426">
        <property type="entry name" value="HISTONE H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00125">
        <property type="entry name" value="Histone"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00622">
        <property type="entry name" value="HISTONEH3"/>
    </dbReference>
    <dbReference type="SMART" id="SM00428">
        <property type="entry name" value="H3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47113">
        <property type="entry name" value="Histone-fold"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00322">
        <property type="entry name" value="HISTONE_H3_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00959">
        <property type="entry name" value="HISTONE_H3_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0158">Chromosome</keyword>
    <keyword evidence="5" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="7 8" id="KW-0544">Nucleosome core</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Core Histone H2A/H2B/H3" evidence="10">
        <location>
            <begin position="57"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="1"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004286"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00010343"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU004471"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF00125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87921.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="148" mass="16813" checksum="41CF5EF9D95BD685" modified="2005-04-12" version="1" fragment="single">ESEDNKANKVLLKMARTKQTARKSTGGKAPRKQLASKGARKSAPVTGGVKKPRRYRPGTVALREIRRYQRSTELLIRKLPFQRLVREIAQDFKTDLRFQSSAVMALQEAAEAYLVGLFEDTNLCAIHAHRVTIMPKDVQLARRIRGER</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQX8</accession>
    <name>Q5CQX8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">9 transmembrane domain protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd4_2890</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87819.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625874.1">
        <property type="nucleotide sequence ID" value="XM_625874.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQX8"/>
    <dbReference type="GeneID" id="3372997"/>
    <dbReference type="KEGG" id="cpv:cgd4_2890"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2890"/>
    <dbReference type="InParanoid" id="Q5CQX8"/>
    <dbReference type="OMA" id="KISEWWH"/>
    <dbReference type="OrthoDB" id="343748at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="59"/>
            <end position="80"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="92"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="124"/>
            <end position="146"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="152"/>
            <end position="170"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="223"/>
            <end position="241"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="272"/>
            <end position="292"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="362"/>
            <end position="382"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK87819.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="677" mass="80146" checksum="393462A1F8D1D90B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQY3</accession>
    <name>Q5CQY3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">Mra1/NEP1 like protein, involved in pre-rRNA processing, adjacent genes putative paralogs</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd4_2840</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
            <location evidence="1">Nucleolus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87930.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625869.1">
        <property type="nucleotide sequence ID" value="XM_625869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQY3"/>
    <dbReference type="FunCoup" id="Q5CQY3">
        <property type="interactions" value="350"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CQY3"/>
    <dbReference type="GeneID" id="3372974"/>
    <dbReference type="KEGG" id="cpv:cgd4_2840"/>
    <dbReference type="InParanoid" id="Q5CQY3"/>
    <dbReference type="OMA" id="ECKFSND"/>
    <dbReference type="OrthoDB" id="269804at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032040">
        <property type="term" value="C:small-subunit processome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070037">
        <property type="term" value="F:rRNA (pseudouridine) methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019843">
        <property type="term" value="F:rRNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070475">
        <property type="term" value="P:rRNA base methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18088">
        <property type="entry name" value="Nep1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.1280.10:FF:000003">
        <property type="entry name" value="Ribosomal RNA small subunit methyltransferase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.1280.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029028">
        <property type="entry name" value="Alpha/beta_knot_MTases"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005304">
        <property type="entry name" value="Rbsml_bgen_MeTrfase_EMG1/NEP1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029026">
        <property type="entry name" value="tRNA_m1G_MTases_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636">
        <property type="entry name" value="NEP1/MRA1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12636:SF5">
        <property type="entry name" value="RIBOSOMAL RNA SMALL SUBUNIT METHYLTRANSFERASE NEP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03587">
        <property type="entry name" value="EMG1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF75217">
        <property type="entry name" value="alpha/beta knot"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="10" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0690">Ribosome biogenesis</keyword>
    <keyword evidence="9" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0698">rRNA processing</keyword>
    <keyword evidence="8" id="KW-0699">rRNA-binding</keyword>
    <keyword evidence="7" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="6" id="KW-0808">Transferase</keyword>
    <feature type="non-terminal residue" evidence="11">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008115"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022517"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022552"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022730"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87930.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="223" mass="25406" checksum="B4CDBBB287468FA1" modified="2005-04-12" version="1" fragment="single">FNFVRFLELYEKKDKSLELLNGIDHPKKKIEEYCSLYSSKIFSKEEMILNIRPDILHQCLLSLLDSPLNKSGRLLVYIRTMSNVLIEVNPQLSVPRSFKEFSSLMVNLLVKRKITAVNGNTSLMRIVKNDIDKILPVGGKKYGLSLNGTQKNIRALINELYSSEDYKIRNSSVTFVVGAVAYGDPIQSCDFIEEIISISSYPLSAALCCSKICNEFEYLWKIC</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="118" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR10</accession>
    <name>Q5CR10_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">26S proteasome regulatory subunit 26b like AAA ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd4_2540</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3 9">Belongs to the AAA ATPase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87845.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625842.1">
        <property type="nucleotide sequence ID" value="XM_625842.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR10"/>
    <dbReference type="FunCoup" id="Q5CR10">
        <property type="interactions" value="502"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CR10"/>
    <dbReference type="GeneID" id="3372852"/>
    <dbReference type="KEGG" id="cpv:cgd4_2540"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_2540"/>
    <dbReference type="InParanoid" id="Q5CR10"/>
    <dbReference type="OMA" id="QDIGGMD"/>
    <dbReference type="OrthoDB" id="10255768at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000502">
        <property type="term" value="C:proteasome complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd19502">
        <property type="entry name" value="RecA-like_PAN_like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.60:FF:000018">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.40.50.140:FF:000046">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:000033">
        <property type="entry name" value="26S protease regulatory subunit 6B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.60">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.40.50.140">
        <property type="entry name" value="Nucleic acid-binding proteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050221">
        <property type="entry name" value="26S_Proteasome_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003959">
        <property type="entry name" value="ATPase_AAA_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003960">
        <property type="entry name" value="ATPase_AAA_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001270">
        <property type="entry name" value="ClpA/B"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012340">
        <property type="entry name" value="NA-bd_OB-fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032501">
        <property type="entry name" value="Prot_ATP_ID_OB_2nd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23073">
        <property type="entry name" value="26S PROTEASOME REGULATORY SUBUNIT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00004">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16450">
        <property type="entry name" value="Prot_ATP_ID_OB_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00300">
        <property type="entry name" value="CLPPROTEASEA"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00674">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6 9" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5 9" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="7 12" id="KW-0647">Proteasome</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="AAA+ ATPase" evidence="11">
        <location>
            <begin position="180"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="26"/>
            <end position="67"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00006914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022942"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU003651"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="SMART" id="SM00382"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK87845.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="401" mass="45484" checksum="BCF90E567033ADDD" modified="2005-04-12" version="1">MACSLAKSQTIMSGNIDREKYLYGSLKELEKELNFLSIQEDYIKDEQKGLKREFQRAKEEIKRIQSVPLVIGQFLEMIDSRYGIVSSTAGSNYYVRVLSTINREDLKPPASVALHRHSHAIVDILPPEADSSIQMLQMQEKPDVTYSDIGGMDIQKQEVREAVELPLVCPELYQQIGIDPPTGVLLYGPPGTGKTMLAKAVANHTTATFIRVVGSEFVQKYLGEGPRMVRDVFRLARENSPAIVFIDEVDSIATKRFDAQTGADREVQRILLELLNQMDGFDQTTNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQRRLIFQTITAKMNLSEEVDLEEYVSRPEKISAADIAAISQEAGMQAVRKNRYVILPKDFEKGWKIHVKKSDRDFDFYSV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR53</accession>
    <name>Q5CR53_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">RecA family profile 1 domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd4_2060</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87878.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625799.1">
        <property type="nucleotide sequence ID" value="XM_625799.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR53"/>
    <dbReference type="GeneID" id="3372960"/>
    <dbReference type="KEGG" id="cpv:cgd4_2060"/>
    <dbReference type="InParanoid" id="Q5CR53"/>
    <dbReference type="OrthoDB" id="342627at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033063">
        <property type="term" value="C:Rad51B-Rad51C-Rad51D-XRCC2 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033065">
        <property type="term" value="C:Rad51C-XRCC3 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005657">
        <property type="term" value="C:replication fork"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008821">
        <property type="term" value="F:crossover junction DNA endonuclease activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000400">
        <property type="term" value="F:four-way junction DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000707">
        <property type="term" value="P:meiotic DNA recombinase assembly"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007131">
        <property type="term" value="P:reciprocal meiotic recombination"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR052093">
        <property type="entry name" value="HR_Repair_Mediator"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020588">
        <property type="entry name" value="RecA_ATP-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239:SF1">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46239">
        <property type="entry name" value="DNA REPAIR PROTEIN RAD51 HOMOLOG 3 RAD51C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50162">
        <property type="entry name" value="RECA_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="5" id="KW-0234">DNA repair</keyword>
    <keyword evidence="2" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="RecA family profile 1" evidence="7">
        <location>
            <begin position="1"/>
            <end position="72"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS50162"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87878.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="147" mass="16873" checksum="DEAC6855136F4982" modified="2005-04-12" version="1">MCKNNNIGIIIIDSISMLIRICNLSKYCAHIILNTLFLDNQPYRLKMQQKIAKTLENMSKEYSLSIIVTNHMTKKYFDDQKKKDQFANVATGKKNLEPSLGLSWNSLICERLILKREKDLKADSEALNTISVTNSFGEVAFFKVIYS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="64" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CR60</accession>
    <name>Q5CR60_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">TBC domain containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd4_1980</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000008">
        <property type="protein sequence ID" value="EAK87884.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625792.1">
        <property type="nucleotide sequence ID" value="XM_625792.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CR60"/>
    <dbReference type="STRING" id="353152.Q5CR60"/>
    <dbReference type="GeneID" id="3372966"/>
    <dbReference type="KEGG" id="cpv:cgd4_1980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_1980"/>
    <dbReference type="InParanoid" id="Q5CR60"/>
    <dbReference type="OMA" id="QICHKYL"/>
    <dbReference type="OrthoDB" id="294251at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005096">
        <property type="term" value="F:GTPase activator activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031267">
        <property type="term" value="F:small GTPase binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.8.270:FF:000001">
        <property type="entry name" value="TBC1 domain family member 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.8.270">
        <property type="entry name" value="putative rabgap domain of human tbc1 domain family member 14 like domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.472.80">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p, domain 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000195">
        <property type="entry name" value="Rab-GAP-TBC_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035969">
        <property type="entry name" value="Rab-GAP_TBC_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050302">
        <property type="entry name" value="Rab_GAP_TBC_domain"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219:SF9">
        <property type="entry name" value="GTPASE ACTIVATING PROTEIN AND CENTROSOME-ASSOCIATED, ISOFORM B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47219">
        <property type="entry name" value="RAB GTPASE-ACTIVATING PROTEIN 1-LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00566">
        <property type="entry name" value="RabGAP-TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00164">
        <property type="entry name" value="TBC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF47923">
        <property type="entry name" value="Ypt/Rab-GAP domain of gyp1p"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50086">
        <property type="entry name" value="TBC_RABGAP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0343">GTPase activation</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Rab-GAP TBC" evidence="2">
        <location>
            <begin position="114"/>
            <end position="303"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022468"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50086"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87884.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="359" mass="42411" checksum="9A811D75F79E1E97" modified="2005-04-12" version="1">MPKEDLEKASQNKEFVEGEHMSDFEERYNEISKEFPEINDDNVAKFSECENKTIDAENIGDIQSKNSENIKIPHKFDYRSRLIEIEEWRFLCYDFEKFDLEKDHLKILSKLRKGIPAQFRGFIWMKLAEVENIKSEHSENLYYQLSEIKNAPCCGDIYRDISRTFPRHSLFRDKNNHGQNSLFSVLRAYSLYNPDVGYCQGMGFIVGVLLMYMSEEDSFYMLISILGKYKFSGLYLPGLPLLNTHLEKLRKIFKKRIPNLYNHFRNENVDETMYASQWFMTIFAYSFNLDAVARIWDLFFLEGVDLIFKISIAILKILKNSLFNQSFENILHTLKTAPYTININDIIQCALSFKLNYKE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRE6</accession>
    <name>Q5CRE6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">N-acetyltransferase subunit ARD1</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd5_3090</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. ARD1 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88014.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626240.1">
        <property type="nucleotide sequence ID" value="XM_626240.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRE6"/>
    <dbReference type="FunCoup" id="Q5CRE6">
        <property type="interactions" value="196"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRE6"/>
    <dbReference type="GeneID" id="3373252"/>
    <dbReference type="KEGG" id="cpv:cgd5_3090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_3090"/>
    <dbReference type="InParanoid" id="Q5CRE6"/>
    <dbReference type="OMA" id="MSMQNAN"/>
    <dbReference type="OrthoDB" id="25586at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031415">
        <property type="term" value="C:NatA complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990190">
        <property type="term" value="F:protein-N-terminal-glutamate acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd04301">
        <property type="entry name" value="NAT_SF"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045047">
        <property type="entry name" value="Ard1-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091">
        <property type="entry name" value="N-TERMINAL ACETYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23091:SF4">
        <property type="entry name" value="N-TERMINAL AMINO-ACID N(ALPHA)-ACETYLTRANSFERASE NATA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51186">
        <property type="entry name" value="GNAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="4">
        <location>
            <begin position="2"/>
            <end position="154"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00025786"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS51186"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88014.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="161" mass="18662" checksum="1D788DE7593B6327" modified="2005-04-12" version="1">MACIRRATIDDLFTIQQNNLYCLPENYQIKYYYYHSMTWPQLLDIATDSNDPNKSVGYVLGKIEDDSNPLHGHITSIAVLRTHRGFGLAKKLLTQNHHGMQSIYNAPYCSLHVRISNYTAKNLYQKALNYKVDSIEAKYYADKEDAYFMKLYFQGSQVKVS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRI1</accession>
    <name>Q5CRI1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd5_2680</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87986.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626205.1">
        <property type="nucleotide sequence ID" value="XM_626205.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRI1"/>
    <dbReference type="GeneID" id="3373224"/>
    <dbReference type="KEGG" id="cpv:cgd5_2680"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2680"/>
    <dbReference type="InParanoid" id="Q5CRI1"/>
    <dbReference type="OMA" id="LWINWIS"/>
    <dbReference type="OrthoDB" id="338796at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0732">Signal</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="signal peptide" evidence="2">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254292" evidence="2">
        <location>
            <begin position="21"/>
            <end position="1259"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="181"/>
            <end position="204"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="264"/>
            <end position="285"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1139"/>
            <end position="1162"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="1189"/>
            <end position="1217"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK87986.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1259" mass="144334" checksum="2EB98FF514887D2E" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRJ3</accession>
    <name>Q5CRJ3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">MutL family ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd5_2560</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the DNA mismatch repair MutL/HexB family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87976.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626193.1">
        <property type="nucleotide sequence ID" value="XM_626193.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRJ3"/>
    <dbReference type="FunCoup" id="Q5CRJ3">
        <property type="interactions" value="230"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRJ3"/>
    <dbReference type="GeneID" id="3373158"/>
    <dbReference type="KEGG" id="cpv:cgd5_2560"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2560"/>
    <dbReference type="InParanoid" id="Q5CRJ3"/>
    <dbReference type="OMA" id="PLDFCEI"/>
    <dbReference type="OrthoDB" id="10263226at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0032389">
        <property type="term" value="C:MutLalpha complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016887">
        <property type="term" value="F:ATP hydrolysis activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0140664">
        <property type="term" value="F:ATP-dependent DNA damage sensor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030983">
        <property type="term" value="F:mismatched DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006298">
        <property type="term" value="P:mismatch repair"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd16926">
        <property type="entry name" value="HATPase_MutL-MLH-PMS-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.565.10:FF:000079">
        <property type="entry name" value="DNA mismatch repair protein MLH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.230.10">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.565.10">
        <property type="entry name" value="Histidine kinase-like ATPase, C-terminal domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014762">
        <property type="entry name" value="DNA_mismatch_repair_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013507">
        <property type="entry name" value="DNA_mismatch_S5_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036890">
        <property type="entry name" value="HATPase_C_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032189">
        <property type="entry name" value="Mlh1_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002099">
        <property type="entry name" value="MutL/Mlh/PMS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038973">
        <property type="entry name" value="MutL/Mlh/Pms-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR020568">
        <property type="entry name" value="Ribosomal_Su5_D2-typ_SF"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014721">
        <property type="entry name" value="Ribsml_uS5_D2-typ_fold_subgr"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00585">
        <property type="entry name" value="mutl"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10073:SF12">
        <property type="entry name" value="DNA MISMATCH REPAIR PROTEIN MLH1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01119">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13589">
        <property type="entry name" value="HATPase_c_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF16413">
        <property type="entry name" value="Mlh1_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM01340">
        <property type="entry name" value="DNA_mis_repair"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55874">
        <property type="entry name" value="ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54211">
        <property type="entry name" value="Ribosomal protein S5 domain 2-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00058">
        <property type="entry name" value="DNA_MISMATCH_REPAIR_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0227">DNA damage</keyword>
    <keyword evidence="4" id="KW-0234">DNA repair</keyword>
    <keyword evidence="5" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="DNA mismatch repair protein S5" evidence="7">
        <location>
            <begin position="214"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="368"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="431"/>
            <end position="464"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="369"/>
            <end position="387"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="443"/>
            <end position="458"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006082"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022763"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023204"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="SMART" id="SM01340"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK87976.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="817" mass="92990" checksum="3A7436D6059C9DD7" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRK2</accession>
    <name>Q5CRK2_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2 8">tRNA (adenine(58)-N(1))-methyltransferase</fullName>
            <ecNumber evidence="2 8">2.1.1.220</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd5_2470</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="8">
            <text>adenosine(58) in tRNA + S-adenosyl-L-methionine = N(1)-methyladenosine(58) in tRNA + S-adenosyl-L-homocysteine + H(+)</text>
            <dbReference type="Rhea" id="RHEA:43152"/>
            <dbReference type="Rhea" id="RHEA-COMP:10365"/>
            <dbReference type="Rhea" id="RHEA-COMP:10366"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57856"/>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
            <dbReference type="ChEBI" id="CHEBI:74411"/>
            <dbReference type="ChEBI" id="CHEBI:74491"/>
            <dbReference type="EC" id="2.1.1.220"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="8">Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.1.1.220" evidence="2 8"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87970.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626184.1">
        <property type="nucleotide sequence ID" value="XM_626184.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRK2"/>
    <dbReference type="FunCoup" id="Q5CRK2">
        <property type="interactions" value="163"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRK2"/>
    <dbReference type="GeneID" id="3373152"/>
    <dbReference type="KEGG" id="cpv:cgd5_2470"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2470"/>
    <dbReference type="InParanoid" id="Q5CRK2"/>
    <dbReference type="OMA" id="RPDHRMI"/>
    <dbReference type="OrthoDB" id="1925287at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031515">
        <property type="term" value="C:tRNA (m1A) methyltransferase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0160107">
        <property type="term" value="F:tRNA (adenine(58)-N1)-methyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030488">
        <property type="term" value="P:tRNA methylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.330.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.150">
        <property type="entry name" value="Vaccinia Virus protein VP39"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029063">
        <property type="entry name" value="SAM-dependent_MTases_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049470">
        <property type="entry name" value="TRM61_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014816">
        <property type="entry name" value="tRNA_MeTrfase_Gcd14"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12133:SF2">
        <property type="entry name" value="TRNA (ADENINE(58)-N(1))-METHYLTRANSFERASE CATALYTIC SUBUNIT TRMT61A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08704">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF017269">
        <property type="entry name" value="GCD14"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53335">
        <property type="entry name" value="S-adenosyl-L-methionine-dependent methyltransferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51620">
        <property type="entry name" value="SAM_TRM61"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8 11" id="KW-0489">Methyltransferase</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 8 9" id="KW-0949">S-adenosyl-L-methionine</keyword>
    <keyword evidence="4 8" id="KW-0808">Transferase</keyword>
    <keyword evidence="6 8" id="KW-0819">tRNA processing</keyword>
    <feature type="domain" description="tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRM61 C-terminal" evidence="10">
        <location>
            <begin position="100"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <begin position="150"/>
            <end position="153"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="171"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="198"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="9">
        <location>
            <position position="222"/>
        </location>
        <ligand>
            <name>S-adenosyl-L-methionine</name>
            <dbReference type="ChEBI" id="CHEBI:59789"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00012796"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022603"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022691"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022694"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="PIRNR" id="PIRNR017269"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="PIRSR" id="PIRSR017269-1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="Pfam" id="PF08704"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK87970.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="312" mass="35085" checksum="6AFD7EE9C16193DF" modified="2005-04-12" version="1">MKEDEGIPEPTNLGNVSASLEDLEENFEGSNIVNKSYTQRRRYEMCKNGDLVVLFGGYEMVIQVFLEQNGRTQTRNGVFLHNEIIGKNFGSRIFDTSKSKWMVVLKLSPELISISLNHRTQILYQADISLICVLLDASPGKNIIEAGTGSGSLTVSLCRSTNPGGAVYTFEYDQKRHLESIQDFQKYGISNVVCQHRDVCKDGFISPLLDITKTTIHGIFLDLPSPWIAIKHADQVLQKGASIVIFSPCIEQVSKNCNELNLLKYIHIRTFEVLYKPWGIVRGSSKKFPTKGLRYQLPMRGHTGYLSFAIKS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRK4</accession>
    <name>Q5CRK4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd5_2450</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87968.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626182.1">
        <property type="nucleotide sequence ID" value="XM_626182.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRK4"/>
    <dbReference type="GeneID" id="3373150"/>
    <dbReference type="KEGG" id="cpv:cgd5_2450"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2450"/>
    <dbReference type="InParanoid" id="Q5CRK4"/>
    <dbReference type="OrthoDB" id="344338at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK87968.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1159" mass="135379" checksum="BC9DC51EF9D8DBDD" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="82" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRM4</accession>
    <name>Q5CRM4_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase</fullName>
            <ecNumber evidence="5">2.7.8.15</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="15">GlcNAc-1-P transferase</fullName>
        </alternativeName>
        <alternativeName>
            <fullName evidence="16">N-acetylglucosamine-1-phosphate transferase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="20" type="ORF">cgd5_2240</name>
    </gene>
    <organism evidence="20 21">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="20 21" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="21">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="17">UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase that operates in the biosynthetic pathway of dolichol-linked oligosaccharides, the glycan precursors employed in protein asparagine (N)-glycosylation. The assembly of dolichol-linked oligosaccharides begins on the cytosolic side of the endoplasmic reticulum membrane and finishes in its lumen. The sequential addition of sugars to dolichol pyrophosphate produces dolichol-linked oligosaccharides containing fourteen sugars, including two GlcNAcs, nine mannoses and three glucoses. Once assembled, the oligosaccharide is transferred from the lipid to nascent proteins by oligosaccharyltransferases. Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis, transfering GlcNAc-1-P from cytosolic UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol embedded in the cytoplasmic leaflet of the endoplasmic reticulum membrane.</text>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="18">
            <text>a di-trans,poly-cis-dolichyl phosphate + UDP-N-acetyl-alpha-D-glucosamine = an N-acetyl-alpha-D-glucosaminyl-diphospho-di-trans,poly-cis-dolichol + UMP</text>
            <dbReference type="Rhea" id="RHEA:13289"/>
            <dbReference type="Rhea" id="RHEA-COMP:19498"/>
            <dbReference type="Rhea" id="RHEA-COMP:19507"/>
            <dbReference type="ChEBI" id="CHEBI:57683"/>
            <dbReference type="ChEBI" id="CHEBI:57705"/>
            <dbReference type="ChEBI" id="CHEBI:57865"/>
            <dbReference type="ChEBI" id="CHEBI:58427"/>
            <dbReference type="EC" id="2.7.8.15"/>
        </reaction>
        <physiologicalReaction direction="left-to-right" evidence="18">
            <dbReference type="Rhea" id="RHEA:13290"/>
        </physiologicalReaction>
    </comment>
    <comment type="cofactor">
        <cofactor evidence="1">
            <name>Mg(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:18420"/>
        </cofactor>
    </comment>
    <comment type="pathway">
        <text evidence="3">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Endoplasmic reticulum membrane</location>
            <topology evidence="2">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="4">Belongs to the glycosyltransferase 4 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="20">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.7.8.15" evidence="5"/>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK87956.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626162.1">
        <property type="nucleotide sequence ID" value="XM_626162.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRM4"/>
    <dbReference type="FunCoup" id="Q5CRM4">
        <property type="interactions" value="128"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CRM4"/>
    <dbReference type="GeneID" id="3373119"/>
    <dbReference type="KEGG" id="cpv:cgd5_2240"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_2240"/>
    <dbReference type="InParanoid" id="Q5CRM4"/>
    <dbReference type="OMA" id="LPHFNAR"/>
    <dbReference type="OrthoDB" id="10262326at2759"/>
    <dbReference type="UniPathway" id="UPA00378"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016757">
        <property type="term" value="F:glycosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003975">
        <property type="term" value="F:UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006488">
        <property type="term" value="P:dolichol-linked oligosaccharide biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06855">
        <property type="entry name" value="GT_GPT_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000715">
        <property type="entry name" value="Glycosyl_transferase_4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033895">
        <property type="entry name" value="GPT"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10571:SF0">
        <property type="entry name" value="UDP-N-ACETYLGLUCOSAMINE--DOLICHYL-PHOSPHATE N-ACETYLGLUCOSAMINEPHOSPHOTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00953">
        <property type="entry name" value="Glycos_transf_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="11" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="7" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="12" id="KW-0460">Magnesium</keyword>
    <keyword evidence="14 19" id="KW-0472">Membrane</keyword>
    <keyword evidence="10" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="21" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8 20" id="KW-0808">Transferase</keyword>
    <keyword evidence="9 19" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="13 19" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="35"/>
            <end position="53"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="117"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="149"/>
            <end position="167"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="216"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="248"/>
            <end position="266"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="278"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="304"/>
            <end position="325"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="332"/>
            <end position="354"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="19">
        <location>
            <begin position="395"/>
            <end position="413"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00001946"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00009317"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00013225"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00017659"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00022842"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="14">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="15">
        <source>
            <dbReference type="ARBA" id="ARBA00029567"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="16">
        <source>
            <dbReference type="ARBA" id="ARBA00033238"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="17">
        <source>
            <dbReference type="ARBA" id="ARBA00044717"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="18">
        <source>
            <dbReference type="ARBA" id="ARBA00045078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="19">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="20">
        <source>
            <dbReference type="EMBL" id="EAK87956.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="21">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="424" mass="48123" checksum="C93005A9DAEF34FF" modified="2005-04-12" version="1">MVNNNKFQRSGEFVIITILIILLVITNISLFKTSYFLHTLICSISSLLTYLVCSKLIPTFGEKLLENGLFGIDINKRSDSISNINSKTNLLEENECKNNELVILDKKDIVEKKIPESLGIVPASMFMMTAICSQILFSNDPVKLLEYNSGLFSICMMTFLGFVDDVLNLKWRYKMVLPVFAALPTLVSYNGGTQIVLPLFQTGGDYSARILIDLGYFYYLYMLCLTVFCTNSINIYAGVNGLEVGQSIIISASIIVYNIIEMLTILPNWQFSFKSNHHFFSILLLLPFTASSLSLFHFNRYPSLVFVGDTYTYFAGACFAIVSILGHFSKTLLLFFLPQILNFIISIPQLFGIVHCPRHRVPKLNKKTGKLESSKNLTLLNLVLEVTGPLTERQLVYYLLVIQIISSIFGFFVRYSPFFRIFFE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CRY9</accession>
    <name>Q5CRY9_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Oxidation resistance protein 1</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd5_960</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Mitochondrion</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the OXR1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000007">
        <property type="protein sequence ID" value="EAK88142.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626047.1">
        <property type="nucleotide sequence ID" value="XM_626047.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CRY9"/>
    <dbReference type="STRING" id="353152.Q5CRY9"/>
    <dbReference type="GeneID" id="3373129"/>
    <dbReference type="KEGG" id="cpv:cgd5_960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd5_960"/>
    <dbReference type="InParanoid" id="Q5CRY9"/>
    <dbReference type="OMA" id="HYGLWCD"/>
    <dbReference type="OrthoDB" id="26679at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 5"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006979">
        <property type="term" value="P:response to oxidative stress"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006571">
        <property type="entry name" value="TLDc_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354:SF62">
        <property type="entry name" value="MUSTARD, ISOFORM V"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23354">
        <property type="entry name" value="NUCLEOLAR PROTEIN 7/ESTROGEN RECEPTOR COACTIVATOR-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07534">
        <property type="entry name" value="TLD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00584">
        <property type="entry name" value="TLDc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51886">
        <property type="entry name" value="TLDC"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="TLDc" evidence="5">
        <location>
            <begin position="14"/>
            <end position="240"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004173"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009540"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023128"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040604"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS51886"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK88142.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="244" mass="27755" checksum="6A89BF6311D1DC4E" modified="2005-04-12" version="1">MWLTSFKVPEGAKKILNEGMVDEITSYLPIVLALRRWQLSFCSKLHGVSFGSFYRRVSNKGPSILVVRDTNGVVFGAFISESIRNSTNYYGTGEMFVFTYKQLSTIDTKNPTEKTEFNYLEPSKSNCDLRTSMKDCFTEFAVSEYRLAREESNFRKNGDNLKESSKSISRISVFPWSGKNCFYIYTDNSRIAIGGGGSYSLTIDGEFFRGWSSPCSTYDSPTLSSHEDFLVNAFQVWTLVDDYQ</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="63" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSA8</accession>
    <name>Q5CSA8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="7">F-actin-capping protein subunit beta</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_3460</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="7">F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.</text>
    </comment>
    <comment type="subunit">
        <text evidence="7">Heterodimer of an alpha and a beta subunit.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 7">Cytoplasm</location>
            <location evidence="1 7">Cytoskeleton</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the F-actin-capping protein beta subunit family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88546.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628159.1">
        <property type="nucleotide sequence ID" value="XM_628159.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSA8"/>
    <dbReference type="FunCoup" id="Q5CSA8">
        <property type="interactions" value="358"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CSA8"/>
    <dbReference type="GeneID" id="3371446"/>
    <dbReference type="KEGG" id="cpv:cgd1_3460"/>
    <dbReference type="InParanoid" id="Q5CSA8"/>
    <dbReference type="OMA" id="TIYYHIS"/>
    <dbReference type="OrthoDB" id="9979678at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008290">
        <property type="term" value="C:F-actin capping protein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003779">
        <property type="term" value="F:actin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051016">
        <property type="term" value="P:barbed-end actin filament capping"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.570">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1150.210">
        <property type="entry name" value="F-actin capping protein, beta subunit"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037282">
        <property type="entry name" value="CapZ_alpha/beta"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR042276">
        <property type="entry name" value="CapZ_alpha/beta_2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001698">
        <property type="entry name" value="CAPZB"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR043175">
        <property type="entry name" value="CAPZB_N"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01115">
        <property type="entry name" value="F_actin_cap_B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF90096">
        <property type="entry name" value="Subunits of heterodimeric actin filament capping protein Capz"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 7" id="KW-0117">Actin capping</keyword>
    <keyword evidence="5 7" id="KW-0009">Actin-binding</keyword>
    <keyword evidence="4 7" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="6 7" id="KW-0206">Cytoskeleton</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004245"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006039"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022467"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023203"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023212"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU365078"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88546.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="319" mass="37274" checksum="33AD770B8A4A9A72" modified="2005-04-12" version="1" fragment="single">IIGDIYPESSKEIFQRIETPLKVILDLETKMYYLGCNSNRIENYFRSPYTYKFYIDPKSKEEYDSEKAESFKEIANNDLNHLKMLETEFQKVYEIYCQNYTYINGGLEEDICDHGVLLSNVYCYDLEGDSFGTCFVMKHIINPFNFLNDNINEKSSTNDLTEIVYFLDIIHNVETVLSHSSGIATYRVGSTYYYGFKDKQKKHSSSGDDENNYNNETILFDGCKTNWVEKKFELSDTKFLKSFLRSNTKSNFNDEVSNENNMQNIAIDRNSITIINNQTIYYHISNIGKLIESIDNNVMKQIQHVMIDNLLNISNNLHE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSG1</accession>
    <name>Q5CSG1_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">MRH domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd1_2870</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88351.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628106.1">
        <property type="nucleotide sequence ID" value="XM_628106.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSG1"/>
    <dbReference type="STRING" id="353152.Q5CSG1"/>
    <dbReference type="GeneID" id="3371719"/>
    <dbReference type="KEGG" id="cpv:cgd1_2870"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_2870"/>
    <dbReference type="InParanoid" id="Q5CSG1"/>
    <dbReference type="OMA" id="GWCSTFT"/>
    <dbReference type="OrthoDB" id="448954at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005788">
        <property type="term" value="C:endoplasmic reticulum lumen"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030968">
        <property type="term" value="P:endoplasmic reticulum unfolded protein response"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030970">
        <property type="term" value="P:retrograde protein transport, ER to cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.390">
        <property type="entry name" value="Hemimethylated DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.70.130.10">
        <property type="entry name" value="Mannose-6-phosphate receptor binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011722">
        <property type="entry name" value="Hemimethylated_DNA-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036623">
        <property type="entry name" value="Hemimethylated_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009011">
        <property type="entry name" value="Man6P_isomerase_rcpt-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044865">
        <property type="entry name" value="MRH_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045149">
        <property type="entry name" value="OS-9-like"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR02097">
        <property type="entry name" value="yccV"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414:SF0">
        <property type="entry name" value="ENDOPLASMIC RETICULUM LECTIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15414">
        <property type="entry name" value="OS-9-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08755">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00992">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50911">
        <property type="entry name" value="Mannose 6-phosphate receptor domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF141255">
        <property type="entry name" value="YccV-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51914">
        <property type="entry name" value="MRH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="3" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="5">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254908" description="MRH domain-containing protein" evidence="5">
        <location>
            <begin position="25"/>
            <end position="692"/>
        </location>
    </feature>
    <feature type="domain" description="MRH" evidence="6">
        <location>
            <begin position="286"/>
            <end position="452"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004240"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022729"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51914"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK88351.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="692" mass="80812" checksum="3029BE7DD238EF74" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="44" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSK7</accession>
    <name>Q5CSK7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Predicted coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd1_2290</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88567.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628060.1">
        <property type="nucleotide sequence ID" value="XM_628060.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSK7"/>
    <dbReference type="FunCoup" id="Q5CSK7">
        <property type="interactions" value="37"/>
    </dbReference>
    <dbReference type="GeneID" id="3371355"/>
    <dbReference type="KEGG" id="cpv:cgd1_2290"/>
    <dbReference type="InParanoid" id="Q5CSK7"/>
    <dbReference type="OMA" id="IGEWYRQ"/>
    <dbReference type="OrthoDB" id="342409at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="30"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="2">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88567.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="680" mass="76890" checksum="F952B5CAE47C77F8" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="60" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSQ1</accession>
    <name>Q5CSQ1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">Cdc50p like membrane protein, 2x transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd1_1760</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 6">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88419.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628016.1">
        <property type="nucleotide sequence ID" value="XM_628016.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSQ1"/>
    <dbReference type="STRING" id="353152.Q5CSQ1"/>
    <dbReference type="GeneID" id="3371631"/>
    <dbReference type="KEGG" id="cpv:cgd1_1760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1760"/>
    <dbReference type="InParanoid" id="Q5CSQ1"/>
    <dbReference type="OMA" id="ENWVGPR"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF015840">
        <property type="entry name" value="DUF284_TM_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6 7" id="KW-0472">Membrane</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 7 8" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 7" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="52"/>
            <end position="73"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="7">
        <location>
            <begin position="302"/>
            <end position="322"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="PIRNR" id="PIRNR015840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88419.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="340" mass="40081" checksum="64ACAC597B809130" modified="2005-04-12" version="1">MNSNYYRHELSNLVWIQRLRKGEKKVDEILESFVQQDMKIWNPGKYLFSPKIAIILFLIGGVFHAVFAAFFFFNYRSNSYVEYISEPIQKNVSSLIFNIENDITGPVNINIYIDNFYQNFRSYVQSRPSDIFPGFTCGTAKTITYLRQVRGNTLDNYINKIQVEKIDETGEEVPLIPCGLSSITFYNDKFEIYMLKEDGKKELLNVEIDQLSLKNDFSMFAVPYNKMMWIKTTDIHYRIWMHGAWLPSFKMVWGQIPHGLERGKYEIKMIDNMWPAENFNSKKRLGIERVSFLGSKNIKASYFFLIWSVWLFTISFLFIFMLSCPCNTLKIILRSFLESI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSR8</accession>
    <name>Q5CSR8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_1590</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88435.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627999.1">
        <property type="nucleotide sequence ID" value="XM_627999.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSR8"/>
    <dbReference type="GeneID" id="3371608"/>
    <dbReference type="KEGG" id="cpv:cgd1_1590"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_1590"/>
    <dbReference type="InParanoid" id="Q5CSR8"/>
    <dbReference type="OrthoDB" id="339022at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88435.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="192" mass="22610" checksum="1EBFF86AA4E0A0B0" modified="2005-04-12" version="1">MLSISPIRGNKKGVLRMPNSEVKERSKPKCSVAFCETVEFRTVYVTKQERLGQFYDLTHWDFINEDNQEHTQNLIADFAATCIPLKDSDESTGNRKIKRLFWNYNDENCCNNFTISWLNSCSNEESSFSTEMDQDSIFHHFEDSYSNEIEYDQQDVTFQEFDADFNCEEFEDSLDDDYFIESEEISISISYK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CST2</accession>
    <name>Q5CST2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_1440</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88447.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627985.1">
        <property type="nucleotide sequence ID" value="XM_627985.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CST2"/>
    <dbReference type="GeneID" id="3371620"/>
    <dbReference type="KEGG" id="cpv:cgd1_1440"/>
    <dbReference type="InParanoid" id="Q5CST2"/>
    <dbReference type="OMA" id="HINFRES"/>
    <dbReference type="OrthoDB" id="341774at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88447.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="308" mass="35341" checksum="1B2B117626E2C199" modified="2005-04-12" version="1">MLESLPSSKPISYFLYNDATEVYRKAHIELLKDYRVVTIRVACRLLIISVLLSSLENLVNKEHSKSLSISYPFLDDIIIRPKSTARSNVTKVLNRILNSIRNYGRRIKIGIKKKVGMSDEFEIIGADSPEINEKEFLSAIYNHRQGSVRSIFGKDEAIFENKQEVFQVINNFIGKQERDSGILLQILETVIRKELGIESSQELQWNSEAKRKLTNVCRDSHVLEILPNRIKFKTCRQLFNKAGEILTGSHFKNSEKESRMAGRANVLKKIRRISSIKFIQVSIKLSQTDINRSNSAKIYSLLVNINIL</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="101" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CSY7</accession>
    <name>Q5CSY7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Protein kinase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd1_810</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88493.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627930.1">
        <property type="nucleotide sequence ID" value="XM_627930.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CSY7"/>
    <dbReference type="STRING" id="353152.Q5CSY7"/>
    <dbReference type="GeneID" id="3371569"/>
    <dbReference type="KEGG" id="cpv:cgd1_810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_810"/>
    <dbReference type="InParanoid" id="Q5CSY7"/>
    <dbReference type="OMA" id="KHCIHEI"/>
    <dbReference type="OrthoDB" id="248923at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004672">
        <property type="term" value="F:protein kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.200.20">
        <property type="entry name" value="Phosphorylase Kinase, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.510.10">
        <property type="entry name" value="Transferase(Phosphotransferase) domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000719">
        <property type="entry name" value="Prot_kinase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017441">
        <property type="entry name" value="Protein_kinase_ATP_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008271">
        <property type="entry name" value="Ser/Thr_kinase_AS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR24345">
        <property type="entry name" value="SERINE/THREONINE-PROTEIN KINASE PLK"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00069">
        <property type="entry name" value="Pkinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00220">
        <property type="entry name" value="S_TKc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00107">
        <property type="entry name" value="PROTEIN_KINASE_ATP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50011">
        <property type="entry name" value="PROTEIN_KINASE_DOM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00108">
        <property type="entry name" value="PROTEIN_KINASE_ST"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 3" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="5" id="KW-0418">Kinase</keyword>
    <keyword evidence="1 3" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="Protein kinase" evidence="4">
        <location>
            <begin position="192"/>
            <end position="463"/>
        </location>
    </feature>
    <feature type="binding site" evidence="3">
        <location>
            <position position="221"/>
        </location>
        <ligand>
            <name>ATP</name>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU10141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50011"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK88493.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="600" mass="68800" checksum="C361276C7480042C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="41" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT37</accession>
    <name>Q5CT37_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd1_180</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88529.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627880.1">
        <property type="nucleotide sequence ID" value="XM_627880.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT37"/>
    <dbReference type="GeneID" id="3371429"/>
    <dbReference type="KEGG" id="cpv:cgd1_180"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_180"/>
    <dbReference type="InParanoid" id="Q5CT37"/>
    <dbReference type="OMA" id="DEYEHNT"/>
    <dbReference type="OrthoDB" id="340594at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="66"/>
            <end position="134"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="268"/>
            <end position="291"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="360"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="318"/>
            <end position="345"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="66"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="112"/>
            <end position="124"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="279"/>
            <end position="288"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88529.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="528" mass="60469" checksum="75D1DD23647B440A" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT48</accession>
    <name>Q5CT48_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd1_70</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000006">
        <property type="protein sequence ID" value="EAK88537.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627869.1">
        <property type="nucleotide sequence ID" value="XM_627869.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT48"/>
    <dbReference type="GeneID" id="3371437"/>
    <dbReference type="KEGG" id="cpv:cgd1_70"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd1_70"/>
    <dbReference type="InParanoid" id="Q5CT48"/>
    <dbReference type="OrthoDB" id="337898at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88537.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="118" mass="13061" checksum="55A44E5073AEB950" modified="2005-04-12" version="1">MIDNAEVPLQRQIQNQKRIKISVKPHLILKRLFGTQANACNPENLVAPFKGLDGASLIASRFNRASGGIELLQRCDGSQYNEALVELESESYGDVICVPDPPRPSWLCSGLSVYCKPY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="43" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CT81</accession>
    <name>Q5CT81_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd2_4060</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626588.1">
        <property type="nucleotide sequence ID" value="XM_626588.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CT81"/>
    <dbReference type="GeneID" id="3373492"/>
    <dbReference type="KEGG" id="cpv:cgd2_4060"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_4060"/>
    <dbReference type="InParanoid" id="Q5CT81"/>
    <dbReference type="OMA" id="WIFFFAS"/>
    <dbReference type="OrthoDB" id="343873at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="42"/>
            <end position="64"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="84"/>
            <end position="104"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="125"/>
            <end position="143"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="155"/>
            <end position="174"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="253"/>
            <end position="272"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="614"/>
            <end position="631"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="637"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="681"/>
            <end position="709"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="715"/>
            <end position="734"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="403"/>
            <end position="438"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="403"/>
            <end position="421"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="425"/>
            <end position="438"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK88631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="742" mass="86522" checksum="352484D7A60C001C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTJ2</accession>
    <name>Q5CTJ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">U5 small nuclear ribonucleoprotein 200kDA helicase, Pre-mRNA splicing helicase BRR2 2 (RNA helicase plus Sec63 domain)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd2_2770</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88725.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626477.1">
        <property type="nucleotide sequence ID" value="XM_626477.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTJ2"/>
    <dbReference type="GeneID" id="3373469"/>
    <dbReference type="KEGG" id="cpv:cgd2_2770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2770"/>
    <dbReference type="InParanoid" id="Q5CTJ2"/>
    <dbReference type="OMA" id="MCSATEF"/>
    <dbReference type="OrthoDB" id="5575at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004386">
        <property type="term" value="F:helicase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016787">
        <property type="term" value="F:hydrolase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003676">
        <property type="term" value="F:nucleic acid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd18795">
        <property type="entry name" value="SF2_C_Ski2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.300:FF:003287">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein 200 kDa helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="1.10.10.10:FF:000024">
        <property type="entry name" value="U5 small nuclear ribonucleoprotein helicase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.150">
        <property type="entry name" value="C2 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="4"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.3380.10">
        <property type="entry name" value="Sec63 N-terminal domain-like domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.10">
        <property type="entry name" value="Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003593">
        <property type="entry name" value="AAA+_ATPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035892">
        <property type="entry name" value="C2_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011545">
        <property type="entry name" value="DEAD/DEAH_box_helicase_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050474">
        <property type="entry name" value="Hel308_SKI2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014001">
        <property type="entry name" value="Helicase_ATP-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001650">
        <property type="entry name" value="Helicase_C-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004179">
        <property type="entry name" value="Sec63-dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036388">
        <property type="entry name" value="WH-like_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036390">
        <property type="entry name" value="WH_DNA-bd_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR057842">
        <property type="entry name" value="WH_MER3"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961:SF4">
        <property type="entry name" value="ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR47961">
        <property type="entry name" value="DNA POLYMERASE THETA, PUTATIVE (AFU_ORTHOLOGUE AFUA_1G05260)-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00270">
        <property type="entry name" value="DEAD"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00271">
        <property type="entry name" value="Helicase_C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02889">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23445">
        <property type="entry name" value="WHD_SNRNP200"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF039073">
        <property type="entry name" value="BRR2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00382">
        <property type="entry name" value="AAA"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00487">
        <property type="entry name" value="DEXDc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00490">
        <property type="entry name" value="HELICc"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00973">
        <property type="entry name" value="Sec63"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158702">
        <property type="entry name" value="Sec63 N-terminal domain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46785">
        <property type="entry name" value="Winged helix' DNA-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51192">
        <property type="entry name" value="HELICASE_ATP_BIND_1"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51194">
        <property type="entry name" value="HELICASE_CTER"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="3 8" id="KW-0347">Helicase</keyword>
    <keyword evidence="2" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="1" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="246"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="586"/>
            <end position="756"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase ATP-binding" evidence="6">
        <location>
            <begin position="1261"/>
            <end position="1459"/>
        </location>
    </feature>
    <feature type="domain" description="Helicase C-terminal" evidence="7">
        <location>
            <begin position="1532"/>
            <end position="1709"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="5">
        <location>
            <begin position="475"/>
            <end position="509"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="5">
        <location>
            <begin position="491"/>
            <end position="509"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022806"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51192"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51194"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK88725.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2184" mass="250323" checksum="B176C663FDF13407" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="106" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTN9</accession>
    <name>Q5CTN9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Zuotin related factor-1 like protein with a DNAJ domain at the N-terminus and 2 SANT domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd2_2260</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88768.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626430.1">
        <property type="nucleotide sequence ID" value="XM_626430.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTN9"/>
    <dbReference type="SMR" id="Q5CTN9"/>
    <dbReference type="FunCoup" id="Q5CTN9">
        <property type="interactions" value="334"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CTN9"/>
    <dbReference type="GeneID" id="3373512"/>
    <dbReference type="KEGG" id="cpv:cgd2_2260"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_2260"/>
    <dbReference type="InParanoid" id="Q5CTN9"/>
    <dbReference type="OMA" id="SFWYDFD"/>
    <dbReference type="OrthoDB" id="1690618at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030544">
        <property type="term" value="F:Hsp70 protein binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043022">
        <property type="term" value="F:ribosome binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051083">
        <property type="term" value="P:'de novo' cotranslational protein folding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006450">
        <property type="term" value="P:regulation of translational fidelity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd06257">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00167">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.287.110">
        <property type="entry name" value="DnaJ domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.10.60">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001623">
        <property type="entry name" value="DnaJ_domain"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009057">
        <property type="entry name" value="Homeodomain-like_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036869">
        <property type="entry name" value="J_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001005">
        <property type="entry name" value="SANT/Myb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR054076">
        <property type="entry name" value="ZUO1-like_ZHD"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR044634">
        <property type="entry name" value="Zuotin/DnaJC2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR43999:SF1">
        <property type="entry name" value="DNAJ HOMOLOG SUBFAMILY C MEMBER 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00226">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF23082">
        <property type="entry name" value="Myb_DNA-binding_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF21884">
        <property type="entry name" value="ZUO1-like_ZHD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00625">
        <property type="entry name" value="JDOMAIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00271">
        <property type="entry name" value="DnaJ"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00717">
        <property type="entry name" value="SANT"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46565">
        <property type="entry name" value="Chaperone J-domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF46689">
        <property type="entry name" value="Homeodomain-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50076">
        <property type="entry name" value="DNAJ_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50090">
        <property type="entry name" value="MYB_LIKE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="J" evidence="2">
        <location>
            <begin position="117"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="domain" description="Myb-like" evidence="3">
        <location>
            <begin position="621"/>
            <end position="669"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="307"/>
            <end position="350"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="PROSITE" id="PS50076"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS50090"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK88768.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="677" mass="79788" checksum="C30500B35866BBB4" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTQ9</accession>
    <name>Q5CTQ9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_2030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88786.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626410.1">
        <property type="nucleotide sequence ID" value="XM_626410.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTQ9"/>
    <dbReference type="GeneID" id="3373530"/>
    <dbReference type="KEGG" id="cpv:cgd2_2030"/>
    <dbReference type="InParanoid" id="Q5CTQ9"/>
    <dbReference type="OMA" id="KFCIELE"/>
    <dbReference type="OrthoDB" id="336317at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88786.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="184" mass="22022" checksum="57538F83E0A55165" modified="2005-04-12" version="1">MGNILYYLIGQRNYHYYDEIALDCGVNMFSIQKNVEQTKILKYKSLSMKISEAESLYNKLMDMRYHTEQIIDKYNSLTRLFEGIHCKICYLDFAQRWVYQQDCNKFYKYCIELEARIAEQDESIKRKYLEYCDFVQLYSIKSGKIKYLNKYPGLKTCLLLSRKCPKCYESKKISHSQAKVSINN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="53" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CTU2</accession>
    <name>Q5CTU2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Origin recognition complex 4 orc4p like AAA+ ATpase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd2_1550</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88917.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626377.1">
        <property type="nucleotide sequence ID" value="XM_626377.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CTU2"/>
    <dbReference type="STRING" id="353152.Q5CTU2"/>
    <dbReference type="GeneID" id="3373679"/>
    <dbReference type="KEGG" id="cpv:cgd2_1550"/>
    <dbReference type="InParanoid" id="Q5CTU2"/>
    <dbReference type="OMA" id="MINSTSR"/>
    <dbReference type="OrthoDB" id="343623at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005664">
        <property type="term" value="C:nuclear origin of replication recognition complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003688">
        <property type="term" value="F:DNA replication origin binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006270">
        <property type="term" value="P:DNA replication initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.300">
        <property type="entry name" value="P-loop containing nucleotide triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016527">
        <property type="entry name" value="ORC4"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027417">
        <property type="entry name" value="P-loop_NTPase"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12087:SF0">
        <property type="entry name" value="ORIGIN RECOGNITION COMPLEX SUBUNIT 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52540">
        <property type="entry name" value="P-loop containing nucleoside triphosphate hydrolases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK88917.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="495" mass="57175" checksum="0F9E2F6E44D157F7" modified="2005-04-12" version="1" fragment="single">ILKVYEHLFCGKNYSYKLLSVLQGQIRTYLLNLHENLTEEHQVSRCDNSLVIPNQLENIFDQIMINSTSRSCILIGKPCAGKTKLLSSYFNKKKSENVSNELIIIHLNCLNYDDNTLLSALLERINEYFPMHRRLFSGHQKISILKEKLSGLSKCGYTIVFALDNCEPIIIGASNISYFNSNTAGFSSRQYALYTLVDIMHSSEINLVLILSTSMFDLPDFFEKRVKSRMSQRRILLEELQNTKKQDRVKSIINKAAKVLKIDKRLVSEIDQLSIDSYNDSIDSLFSYLADENKESREVIRSWEFLVDFEMEDEVLSNLLYKFLLVSPQCNIKEFMKIFSASNKKKLSKNRNEFGLLNQGIKVQECLKLKRFESLSIIQHTILVALIKLITLGVTNITFKKIINELHSLKNYISVQSNLSGLRLDHAEESYQLSFLMLVKMGIIEPVYNIKTNALYSTLSTTPVKFTQHKLYSDSIQQFNIPTILQYWLKNNILK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="37" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CU01</accession>
    <name>Q5CU01_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd2_850</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000005">
        <property type="protein sequence ID" value="EAK88864.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626318.1">
        <property type="nucleotide sequence ID" value="XM_626318.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CU01"/>
    <dbReference type="GeneID" id="3373607"/>
    <dbReference type="KEGG" id="cpv:cgd2_850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd2_850"/>
    <dbReference type="InParanoid" id="Q5CU01"/>
    <dbReference type="OMA" id="FESTCPY"/>
    <dbReference type="OrthoDB" id="336770at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 2"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004253849" evidence="1">
        <location>
            <begin position="28"/>
            <end position="312"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK88864.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="312" mass="35435" checksum="246FA23E612AF9B3" modified="2005-04-12" version="1">MRKTNRWEGIILFLILHVLIKFKHVIGEITNVLNFQADIIVPLATGGDLPPDNNYDVYRRIWRASQSEIEDLERKSLDFFKEMTDVDIAGLPACSIGNTFNGFGGGILSIIPAFKSQFKVVETPERPQLSGLCLLRSMDGVAYIYDQGTQLRVASIYHVRNMDIIGYKLVQSLIPQHEATESPLPLFDTAFLLNVLEDGYLPCSKFQGSCIKGDRLLYGWYTIRDIYNKGEWGVIHYESSGPQNILKEFTPLSFNLNSPVWGKGYSNGFVSRRFVNNDYVQPCHENACPYRMSKMFDTVSVSFRNILTFVTA</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUG6</accession>
    <name>Q5CUG6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd3_2910</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89039.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626848.1">
        <property type="nucleotide sequence ID" value="XM_626848.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUG6"/>
    <dbReference type="GeneID" id="3374103"/>
    <dbReference type="KEGG" id="cpv:cgd3_2910"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_2910"/>
    <dbReference type="InParanoid" id="Q5CUG6"/>
    <dbReference type="OMA" id="IMNTHEN"/>
    <dbReference type="OrthoDB" id="338528at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89039.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="222" mass="25526" checksum="7EE9B7FF5CE04043" modified="2005-04-12" version="1">MSYIECSKVGRVNINQLEDLLDLLKSLCVEVKLVKWRENTWCPNVMESHCFSRKLDFTKAQKHTEAEARILQYIYPTESKDLVNISYQTPIIEPTTNSLEMALTSDKDKKATIQVNKVVECFSSKSILEIMQHLNIGSLNSTPPTLYNTLYISCYLCTFNPLKADEVVIFVQTEFKDINFNYNSNDHILVILKSKCLNENVISTNKQAILNLSRKLEKIVSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUN6</accession>
    <name>Q5CUN6_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="6">40S ribosomal protein SA</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_2090</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 7">Belongs to the universal ribosomal protein uS2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89271.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626778.1">
        <property type="nucleotide sequence ID" value="XM_626778.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUN6"/>
    <dbReference type="STRING" id="353152.Q5CUN6"/>
    <dbReference type="GeneID" id="3373786"/>
    <dbReference type="KEGG" id="cpv:cgd3_2090"/>
    <dbReference type="InParanoid" id="Q5CUN6"/>
    <dbReference type="OMA" id="VKNFFEP"/>
    <dbReference type="OrthoDB" id="414863at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01425">
        <property type="entry name" value="RPS2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.40.50.10490:FF:000012">
        <property type="entry name" value="40S ribosomal protein SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.10490">
        <property type="entry name" value="Glucose-6-phosphate isomerase like protein, domain 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_03015">
        <property type="entry name" value="Ribosomal_S2_euk"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001865">
        <property type="entry name" value="Ribosomal_uS2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018130">
        <property type="entry name" value="Ribosomal_uS2_CS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027498">
        <property type="entry name" value="Ribosomal_uS2_euk"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005707">
        <property type="entry name" value="Ribosomal_uS2_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023591">
        <property type="entry name" value="Ribosomal_uS2_flav_dom_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01012">
        <property type="entry name" value="uS2_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11489">
        <property type="entry name" value="40S RIBOSOMAL PROTEIN SA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00318">
        <property type="entry name" value="Ribosomal_S2"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00395">
        <property type="entry name" value="RIBOSOMALS2"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52313">
        <property type="entry name" value="Ribosomal protein S2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00962">
        <property type="entry name" value="RIBOSOMAL_S2_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00963">
        <property type="entry name" value="RIBOSOMAL_S2_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5 7" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="4 7 8" id="KW-0689">Ribosomal protein</keyword>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00035401"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="RuleBase" id="RU003631"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89271.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="260" mass="28788" checksum="A33AF3D675CF049F" modified="2005-04-12" version="1" fragment="single">LYSNMPPAETRKLDDIAKMIVCKTHIGTKNVEDKMLSYVYKRTHEGIFLINLAKTWEKIQIAARIIATIDNLADVVVVSQRPYGSRPALKFAQHTGAHAMVGRFTPGTLTNQITQKFMEPRLLIVTDPRVDSQAVIESSYANIPVIALCDTDSPLQYVDVAIPCNNKGKESIALMYYLLAREVNFLRGKTDKWDVMVDVFFWRDPEEYENSAIGADMELNDGMGVDIEGAAVDSAAAANEWGGVSGNWGGSAADEWRNAP</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="105" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUP3</accession>
    <name>Q5CUP3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">PP2C like protein phosphatase</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd3_2020</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Peripheral membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="5">Belongs to the PP2C family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89274.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626771.1">
        <property type="nucleotide sequence ID" value="XM_626771.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUP3"/>
    <dbReference type="STRING" id="353152.Q5CUP3"/>
    <dbReference type="GeneID" id="3373828"/>
    <dbReference type="KEGG" id="cpv:cgd3_2020"/>
    <dbReference type="InParanoid" id="Q5CUP3"/>
    <dbReference type="OMA" id="YCAMKLP"/>
    <dbReference type="OrthoDB" id="10264738at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004722">
        <property type="term" value="F:protein serine/threonine phosphatase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00143">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.60.40.10">
        <property type="entry name" value="PPM-type phosphatase domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015655">
        <property type="entry name" value="PP2C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000222">
        <property type="entry name" value="PP2C_BS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036457">
        <property type="entry name" value="PPM-type-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001932">
        <property type="entry name" value="PPM-type_phosphatase-like_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13832:SF840">
        <property type="entry name" value="PROTEIN PHOSPHATASE 2C 60-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00481">
        <property type="entry name" value="PP2C"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="SMART" id="SM00332">
        <property type="entry name" value="PP2Cc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81606">
        <property type="entry name" value="PP2C-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01032">
        <property type="entry name" value="PPM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51746">
        <property type="entry name" value="PPM_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 5" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="2" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="4 5" id="KW-0904">Protein phosphatase</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="PPM-type phosphatase" evidence="7">
        <location>
            <begin position="34"/>
            <end position="532"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="134"/>
            <end position="164"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="195"/>
            <end position="282"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="451"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="6">
        <location>
            <begin position="568"/>
            <end position="609"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="143"/>
            <end position="155"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="210"/>
            <end position="231"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="452"/>
            <end position="472"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="6">
        <location>
            <begin position="568"/>
            <end position="583"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="6">
        <location>
            <begin position="589"/>
            <end position="607"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="8">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004170"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022912"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="RuleBase" id="RU003465"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="7">
        <source>
            <dbReference type="PROSITE" id="PS51746"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89274.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="648" mass="71133" checksum="9C3352B231487A5A" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUP6</accession>
    <name>Q5CUP6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1980</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89100.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626768.1">
        <property type="nucleotide sequence ID" value="XM_626768.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUP6"/>
    <dbReference type="STRING" id="353152.Q5CUP6"/>
    <dbReference type="GeneID" id="3374049"/>
    <dbReference type="KEGG" id="cpv:cgd3_1980"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1980"/>
    <dbReference type="InParanoid" id="Q5CUP6"/>
    <dbReference type="OMA" id="NNIMALL"/>
    <dbReference type="OrthoDB" id="342846at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="1"/>
            <end position="21"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="181"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="314"/>
            <end position="351"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="490"/>
            <end position="520"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="610"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="654"/>
            <end position="689"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="1"/>
            <end position="10"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="181"/>
            <end position="193"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="195"/>
            <end position="207"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="330"/>
            <end position="348"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="502"/>
            <end position="518"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="591"/>
            <end position="600"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="673"/>
            <end position="689"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89100.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="943" mass="98019" checksum="383A052E93CF05E3" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUT0</accession>
    <name>Q5CUT0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Protein containing a possible START(Steroidogenic acute regulatory (STAR) related lipid transfer) domain</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd3_1610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89131.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626734.1">
        <property type="nucleotide sequence ID" value="XM_626734.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUT0"/>
    <dbReference type="STRING" id="353152.Q5CUT0"/>
    <dbReference type="GeneID" id="3374021"/>
    <dbReference type="KEGG" id="cpv:cgd3_1610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1610"/>
    <dbReference type="InParanoid" id="Q5CUT0"/>
    <dbReference type="OrthoDB" id="333905at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008289">
        <property type="term" value="F:lipid binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00177">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.530.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR023393">
        <property type="entry name" value="START-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002913">
        <property type="entry name" value="START_lipid-bd_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051213">
        <property type="entry name" value="START_lipid_transfer"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308">
        <property type="entry name" value="PHOSPHATIDYLCHOLINE TRANSFER PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19308:SF14">
        <property type="entry name" value="START DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01852">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55961">
        <property type="entry name" value="Bet v1-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50848">
        <property type="entry name" value="START"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="START" evidence="1">
        <location>
            <begin position="392"/>
            <end position="588"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="PROSITE" id="PS50848"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89131.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="855" mass="97634" checksum="082C1CC287FACA09" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="54" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUW7</accession>
    <name>Q5CUW7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">CNNM transmembrane domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_1210</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89161.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626697.1">
        <property type="nucleotide sequence ID" value="XM_626697.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CUW7"/>
    <dbReference type="STRING" id="353152.Q5CUW7"/>
    <dbReference type="GeneID" id="3374165"/>
    <dbReference type="KEGG" id="cpv:cgd3_1210"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_1210"/>
    <dbReference type="InParanoid" id="Q5CUW7"/>
    <dbReference type="OMA" id="CEYEIRK"/>
    <dbReference type="OrthoDB" id="5353557at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010960">
        <property type="term" value="P:magnesium ion homeostasis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045095">
        <property type="entry name" value="ACDP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002550">
        <property type="entry name" value="CNNM"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064">
        <property type="entry name" value="METAL TRANSPORTER CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12064:SF94">
        <property type="entry name" value="UNEXTENDED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01595">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51846">
        <property type="entry name" value="CNNM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1 2" id="KW-0472">Membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1 2" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="12"/>
            <end position="34"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="68"/>
            <end position="89"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="95"/>
            <end position="114"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="2">
        <location>
            <begin position="121"/>
            <end position="144"/>
        </location>
    </feature>
    <feature type="domain" description="CNNM transmembrane" evidence="3">
        <location>
            <begin position="5"/>
            <end position="185"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU01193"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="PROSITE" id="PS51846"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89161.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="464" mass="52756" checksum="C4668CE18B81F078" modified="2005-04-12" version="1">MKEVAELHLSALIIITLLLSFGSALFSGLTLGMMTQDLLHLKISSSSKNNKNAAFYAKRLLPLRTNGNFLLVTLLFGNVTVNTGLSILISELTSGWLAFTVSTILIMIFGEIIPQAICSRYGLYIGGFFSPFIRLIQIILFPLLKPISVILDKAVGKTNEKIYTREELNTLLEHHSKKDIISVYELGLIKRVIFSNFTLSDIMIQIDEFHIYYIDSQLETNQIEDFIKKGISKLYIIDNHSTYSELFKDDFQQCLTYTKKNDIIYLDIPNTNDHQSNYIEYSNSPITSETYDSDCSICNDSPHSKSGIILGYIDLDQLSKQNKIFQNKNNSNRISTIVNTKSFIRLTNIVISNKMMDLIRNKDTLSILTSISNIKDKILCIQGSTSISTLFNVLCQYNLSQNDIIIIYSTIGNGHKIRYDGVITLTTLYEYMFSSEKYVVNELKEDICSNLLLKHQHPNISSYF</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="96" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUX5</accession>
    <name>Q5CUX5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">P-type ATpase fused to two adenyl cyclase domains and 21 predicted transmembrane regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd3_1110</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89286.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_626689.1">
        <property type="nucleotide sequence ID" value="XM_626689.1"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CUX5"/>
    <dbReference type="GeneID" id="3373840"/>
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        <property type="component" value="Chromosome 3"/>
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        <property type="term" value="C:plasma membrane"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="F:nucleotide binding"/>
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        <property type="project" value="UniProtKB-KW"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="term" value="P:intracellular signal transduction"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
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        <property type="term" value="P:receptor guanylyl cyclase signaling pathway"/>
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        <property type="project" value="TreeGrafter"/>
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        <property type="match status" value="2"/>
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        <property type="entry name" value="Calcium-transporting ATPase, cytoplasmic transduction domain A"/>
        <property type="match status" value="1"/>
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        <property type="entry name" value="Nucleotide cyclase"/>
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        <property type="entry name" value="ATPase_P-typ_TM_dom_sf"/>
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        <property type="entry name" value="Cyclic_nucleotide_synthase"/>
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        <property type="entry name" value="Nucleotide_cyclase"/>
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    <dbReference type="InterPro" id="IPR032630">
        <property type="entry name" value="P_typ_ATPase_c"/>
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        <property type="entry name" value="GUANYLATE CYCLASE"/>
        <property type="match status" value="1"/>
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    </dbReference>
    <dbReference type="Pfam" id="PF00211">
        <property type="entry name" value="Guanylate_cyc"/>
        <property type="match status" value="3"/>
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        <property type="entry name" value="PhoLip_ATPase_C"/>
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        <property type="match status" value="2"/>
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        <property type="match status" value="1"/>
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    <keyword evidence="2 8 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 8" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="107"/>
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    <feature type="transmembrane region" description="Helical" evidence="8">
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        <location>
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        <location>
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    <feature type="transmembrane region" description="Helical" evidence="8">
        <location>
            <begin position="1965"/>
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        <location>
            <begin position="1991"/>
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            <begin position="2033"/>
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        <location>
            <begin position="2100"/>
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            <begin position="3656"/>
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            <begin position="3011"/>
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            <begin position="3040"/>
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        <location>
            <position position="1"/>
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            <dbReference type="ARBA" id="ARBA00004370"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
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        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
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        <source>
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        <source>
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        <source>
            <dbReference type="PROSITE" id="PS50125"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAK89286.1"/>
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    </evidence>
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        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="3848" mass="440179" checksum="5F3449AE8922FF33" modified="2005-04-12" version="1" fragment="single"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CUY3</accession>
    <name>Q5CUY3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd3_1030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000004">
        <property type="protein sequence ID" value="EAK89171.1"/>
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        </location>
    </feature>
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        </location>
    </feature>
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            <begin position="147"/>
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        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
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        </source>
    </evidence>
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        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
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        <source>
            <dbReference type="EMBL" id="EAK89171.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="465" mass="52723" checksum="205C74C3544828DD" modified="2005-04-12" version="1">MSEELKFNGQDAPNEEIHEKKDEDQVGMTFSEREANMNQTAECEEYLEDEEYYEEDEDELNASLDPELLLEEGRKLRKKKKFDEAIVKLYWAMTNRMNLLNITEESGIDPRLSEYYLIYADVLFEKEENSTNFFSKRNEQDTMNSFSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSDPTFIESTVMNMANNSVAEATDEEVAWENFEAAKLAYIKLIYLKKRGDYDAYCQGIIPEYLANLFSSNELNDGKFEELLREVCSCNSEERSRIPDKDITDLSYVFIRLGDILQLAEKYYEASIEYKNSLFILETFKLPEDTTESSLICLAQSTLFSGKIKDSKYLFERALNLVRNHFEGKNGMTAPTDPQQIEAYKLTLEDLQLTLDDINRKLAVNQEDQKPATAIPKLEEIKKENSFNKAQLPENEPVKVINTVDINGSPCENTVDNKKKRRIDLSKV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="39" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CV83</accession>
    <name>Q5CV83_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_5040</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89631.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627386.1">
        <property type="nucleotide sequence ID" value="XM_627386.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CV83"/>
    <dbReference type="GeneID" id="3374208"/>
    <dbReference type="KEGG" id="cpv:cgd8_5040"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_5040"/>
    <dbReference type="InParanoid" id="Q5CV83"/>
    <dbReference type="OrthoDB" id="338332at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89631.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="106" mass="12371" checksum="10DC70E927434BAB" modified="2005-04-12" version="1">MVAALEEIVKHIENNFGDILTLSEIDNSYKDKIIAKATLGLQQNKDNFSKFNEKKIVSLEISQNGFRILEKEDSNFYETIEGFLYSQVPETWIKYFETKISEKLQE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVA5</accession>
    <name>Q5CVA5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">SSM4 like ring finger with a forkhead associated (FHA) domain (Apicomplexan-specific architecture)</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd8_4800</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89613.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627364.1">
        <property type="nucleotide sequence ID" value="XM_627364.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVA5"/>
    <dbReference type="STRING" id="353152.Q5CVA5"/>
    <dbReference type="GeneID" id="3374353"/>
    <dbReference type="KEGG" id="cpv:cgd8_4800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4800"/>
    <dbReference type="InParanoid" id="Q5CVA5"/>
    <dbReference type="OrthoDB" id="264354at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008270">
        <property type="term" value="F:zinc ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="CDD" id="cd00060">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd16495">
        <property type="entry name" value="RING_CH-C4HC3_MARCH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.200.20">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.40.10">
        <property type="entry name" value="Zinc/RING finger domain, C3HC4 (zinc finger)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000253">
        <property type="entry name" value="FHA_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008984">
        <property type="entry name" value="SMAD_FHA_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011016">
        <property type="entry name" value="Znf_RING-CH"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013083">
        <property type="entry name" value="Znf_RING/FYVE/PHD"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46210">
        <property type="entry name" value="FHA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46210:SF1">
        <property type="entry name" value="FHA DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00498">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF12906">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00240">
        <property type="entry name" value="FHA"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00744">
        <property type="entry name" value="RINGv"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF57850">
        <property type="entry name" value="RING/U-box"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF49879">
        <property type="entry name" value="SMAD/FHA domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50006">
        <property type="entry name" value="FHA_DOMAIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51292">
        <property type="entry name" value="ZF_RING_CH"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0862">Zinc</keyword>
    <keyword evidence="2" id="KW-0863">Zinc-finger</keyword>
    <feature type="domain" description="RING-CH-type" evidence="6">
        <location>
            <begin position="266"/>
            <end position="343"/>
        </location>
    </feature>
    <feature type="domain" description="FHA" evidence="5">
        <location>
            <begin position="388"/>
            <end position="437"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="91"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="4">
        <location>
            <begin position="476"/>
            <end position="535"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="4">
        <location>
            <begin position="91"/>
            <end position="101"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Gly residues" evidence="4">
        <location>
            <begin position="494"/>
            <end position="507"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="4">
        <location>
            <begin position="516"/>
            <end position="532"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022723"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022771"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022833"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="5">
        <source>
            <dbReference type="PROSITE" id="PS50006"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="PROSITE" id="PS51292"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89613.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="780" mass="86517" checksum="7D4CA0B86207734C" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVD9</accession>
    <name>Q5CVD9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">WD40 repeat and RING finger domain-containing protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd8_4420</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89580.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627330.1">
        <property type="nucleotide sequence ID" value="XM_627330.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVD9"/>
    <dbReference type="STRING" id="353152.Q5CVD9"/>
    <dbReference type="GeneID" id="3374535"/>
    <dbReference type="KEGG" id="cpv:cgd8_4420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_4420"/>
    <dbReference type="InParanoid" id="Q5CVD9"/>
    <dbReference type="OMA" id="ICEDNRE"/>
    <dbReference type="OrthoDB" id="60955at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035859">
        <property type="term" value="C:Seh1-associated complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005774">
        <property type="term" value="C:vacuolar membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0035591">
        <property type="term" value="F:signaling adaptor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0034198">
        <property type="term" value="P:cellular response to amino acid starvation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1904263">
        <property type="term" value="P:positive regulation of TORC1 signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR049567">
        <property type="entry name" value="WDR59-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR031488">
        <property type="entry name" value="Zn_ribbon_mio"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR46170:SF1">
        <property type="entry name" value="GATOR COMPLEX PROTEIN WDR59"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF17034">
        <property type="entry name" value="zinc_ribbon_16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="GATOR2 complex protein MIO zinc-ribbon like" evidence="1">
        <location>
            <begin position="1003"/>
            <end position="1036"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF17034"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK89580.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1042" mass="120687" checksum="98663A9BCF219362" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="72" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVH5</accession>
    <name>Q5CVH5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Apicomplexan specific coiled coil protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd8_4030</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89552.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627294.1">
        <property type="nucleotide sequence ID" value="XM_627294.1"/>
    </dbReference>
    <dbReference type="FunCoup" id="Q5CVH5">
        <property type="interactions" value="4"/>
    </dbReference>
    <dbReference type="GeneID" id="3374595"/>
    <dbReference type="KEGG" id="cpv:cgd8_4030"/>
    <dbReference type="InParanoid" id="Q5CVH5"/>
    <dbReference type="OMA" id="ECTIENC"/>
    <dbReference type="OrthoDB" id="5334309at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.60.40.10">
        <property type="entry name" value="Immunoglobulins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017868">
        <property type="entry name" value="Filamin/ABP280_repeat-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013783">
        <property type="entry name" value="Ig-like_fold"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014756">
        <property type="entry name" value="Ig_E-set"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR42264">
        <property type="entry name" value="EPHRIN_REC_LIKE DOMAIN-CONTAINING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00630">
        <property type="entry name" value="Filamin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF81296">
        <property type="entry name" value="E set domains"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50194">
        <property type="entry name" value="FILAMIN_REPEAT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="repeat" description="Filamin" evidence="1">
        <location>
            <begin position="600"/>
            <end position="635"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1497"/>
            <end position="1529"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="1500"/>
            <end position="1529"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00087"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89552.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1813" mass="209582" checksum="C5039B6FC698AA91" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVR0</accession>
    <name>Q5CVR0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_3120</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89487.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627209.1">
        <property type="nucleotide sequence ID" value="XM_627209.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVR0"/>
    <dbReference type="GeneID" id="3374237"/>
    <dbReference type="KEGG" id="cpv:cgd8_3120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_3120"/>
    <dbReference type="InParanoid" id="Q5CVR0"/>
    <dbReference type="OrthoDB" id="343063at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89487.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="265" mass="30507" checksum="063565AF3632FCE0" modified="2005-04-12" version="1">MKVSIQIHEDKNKTLNSGYSPNYLESEIETANKQNLIKSASFQTHFGLKLIAEENDTLNKTEKEIHSGTANETKKINNDIYHSRRYPATELNGPFFFSFNQEPNLYNGTTSLDSKLALNDNAITEEESSNYDESQSSKKNSRLFARRITKNYSNEHPYINPFIPIRSQETENKEANQEAISFPVIIRINPEYITGNKPHEDETTDPNVRMKEFKSNFNSIKSFQYSILKFEKLDSQNESFVSEFNSMSTSLILNNPKNSTETEKN</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CVU3</accession>
    <name>Q5CVU3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_2760</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89462.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627176.1">
        <property type="nucleotide sequence ID" value="XM_627176.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CVU3"/>
    <dbReference type="STRING" id="353152.Q5CVU3"/>
    <dbReference type="GeneID" id="3374340"/>
    <dbReference type="KEGG" id="cpv:cgd8_2760"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2760"/>
    <dbReference type="InParanoid" id="Q5CVU3"/>
    <dbReference type="OMA" id="ITCTRIN"/>
    <dbReference type="OrthoDB" id="338868at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89462.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="367" mass="42554" checksum="2FE442CB8F197322" modified="2005-04-12" version="1">MDKLMVWSDEETEKIFQLVVKLLNGCETRNKIMERVQKRTGTRCSSYHQDSSCNSKIEGFIGIKNFSRSKEDKIGNLIDKYLKKNFIYMLLPMIIKKAFLAYNSLKEICTGKSNNIYKENELDISEYNLMITVFSESIIYYCVDKIMDEVKNNYSSKTCDISRWASPYIIKDIVNIIDNQMLYELNEFGITMKSTWFGEEMRNKINKALIKMDYQGLLTNNSVSKSSFSSNFRYAVLESDEIQDEMLVYFNAIEYLPNELNAKLGRNLNILSKSIYILSIEPANTGFIIGKDSESFIPGSKIGIIYFSCKEKIKINCQNNKTKKSVELELSDDKLVIADLNKNKYTFRNFESELVTYCILTYIFGPE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="56" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW49</accession>
    <name>Q5CW49_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="3">GINS subunit domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd8_1630</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89682.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627070.1">
        <property type="nucleotide sequence ID" value="XM_627070.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW49"/>
    <dbReference type="STRING" id="353152.Q5CW49"/>
    <dbReference type="GeneID" id="3374404"/>
    <dbReference type="KEGG" id="cpv:cgd8_1630"/>
    <dbReference type="InParanoid" id="Q5CW49"/>
    <dbReference type="OMA" id="WPWPPIT"/>
    <dbReference type="OrthoDB" id="338231at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000811">
        <property type="term" value="C:GINS complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006261">
        <property type="term" value="P:DNA-templated DNA replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000727">
        <property type="term" value="P:double-strand break repair via break-induced replication"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.58.1030">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036224">
        <property type="entry name" value="GINS_bundle-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR008591">
        <property type="entry name" value="GINS_Sld5"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206:SF0">
        <property type="entry name" value="DNA REPLICATION COMPLEX GINS PROTEIN SLD5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21206">
        <property type="entry name" value="SLD5 PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF007764">
        <property type="entry name" value="Sld5"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF158573">
        <property type="entry name" value="GINS helical bundle-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <feature type="non-terminal residue" evidence="1">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89682.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="3">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="231" mass="26681" checksum="7B81F4CE0C47655A" modified="2005-04-12" version="1" fragment="single">INKSWINELVSPELLTYCESSIQTLSHSIFKEKEKQRIMEVDGGILGIEDKIERDLINLHINRSTNMLKMYLKQRIMKISEFPDFSIANSRTNNDLNSESNISPEEAIFALKLSKLQWKYLDETISKMKNTLATDSSVPIPAPSLHRSVRFKCIDSIGRVQLQSLVTPENVSFTQFDTQNHFSQNDSEGVINIEKGKIYTCKYEDVRTLLDQNTIQLWPWPPITSNKNYSY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="62" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWG5</accession>
    <name>Q5CWG5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_5170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90088.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627839.1">
        <property type="nucleotide sequence ID" value="XM_627839.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWG5"/>
    <dbReference type="GeneID" id="3375833"/>
    <dbReference type="KEGG" id="cpv:cgd6_5170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_5170"/>
    <dbReference type="InParanoid" id="Q5CWG5"/>
    <dbReference type="OMA" id="KEECCIS"/>
    <dbReference type="OrthoDB" id="340878at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="98"/>
            <end position="120"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90088.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="825" mass="95211" checksum="7C93D2AD5A175AA5" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="75" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWQ2</accession>
    <name>Q5CWQ2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">60S ribosomal protein L10, alpha/beta hammerhead</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_4190</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uL16 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90021.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627752.1">
        <property type="nucleotide sequence ID" value="XM_627752.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWQ2"/>
    <dbReference type="FunCoup" id="Q5CWQ2">
        <property type="interactions" value="214"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWQ2"/>
    <dbReference type="GeneID" id="3375766"/>
    <dbReference type="KEGG" id="cpv:cgd6_4190"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4190"/>
    <dbReference type="InParanoid" id="Q5CWQ2"/>
    <dbReference type="OMA" id="HHVIREN"/>
    <dbReference type="OrthoDB" id="10258869at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01433">
        <property type="entry name" value="Ribosomal_L16_L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.90.1170.10:FF:000002">
        <property type="entry name" value="60S ribosomal protein L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.1170.10">
        <property type="entry name" value="Ribosomal protein L10e/L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047873">
        <property type="entry name" value="Ribosomal_uL16"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018255">
        <property type="entry name" value="Ribosomal_uL16_CS_euk_arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016180">
        <property type="entry name" value="Ribosomal_uL16_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001197">
        <property type="entry name" value="Ribosomal_uL16_euk_arch"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036920">
        <property type="entry name" value="Ribosomal_uL16_sf"/>
    </dbReference>
    <dbReference type="NCBIfam" id="NF003239">
        <property type="entry name" value="PRK04199.1-4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00279">
        <property type="entry name" value="uL16_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11726">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00252">
        <property type="entry name" value="Ribosomal_L16"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PIRSF" id="PIRSF005590">
        <property type="entry name" value="Ribosomal_L10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54686">
        <property type="entry name" value="Ribosomal protein L16p/L10e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS01257">
        <property type="entry name" value="RIBOSOMAL_L10E"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 4" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00008931"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90021.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="222" mass="25321" checksum="0ECF197543E06DD5" modified="2007-04-03" version="1">MARRPARCYRYCRGKPYPKSRFCRGVPDPKIRIYDVGRKKAECDAFPAVIHLISDEYEQISSEALEAARISANKYMIKFCGKDNFHLRIRVHPFHVLRINKMLSCAGADRLQTGMRGAYGKPTGTAARVNIGQVLMSIRCKEDKTQTAVMALRRAKYKFPGRQKVVVSDKWGFTKFTKEEYLKYQAEGRIVPDGVNCKYISCRGSLSRIFPEAANINIPLDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="111" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWX0</accession>
    <name>Q5CWX0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Membrane associated protein with 2 transmembrane domains at the N-terminus and a phosphatidylinositol 4-kinase domain at the C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd6_3390</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89962.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627684.1">
        <property type="nucleotide sequence ID" value="XM_627684.1"/>
    </dbReference>
    <dbReference type="SMR" id="Q5CWX0"/>
    <dbReference type="STRING" id="353152.Q5CWX0"/>
    <dbReference type="GeneID" id="3375707"/>
    <dbReference type="KEGG" id="cpv:cgd6_3390"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3390"/>
    <dbReference type="InParanoid" id="Q5CWX0"/>
    <dbReference type="OMA" id="LICNIAT"/>
    <dbReference type="OrthoDB" id="10264149at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0052742">
        <property type="term" value="F:phosphatidylinositol kinase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046854">
        <property type="term" value="P:phosphatidylinositol phosphate biosynthetic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0048015">
        <property type="term" value="P:phosphatidylinositol-mediated signaling"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd05167">
        <property type="entry name" value="PI4Kc_III_alpha"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.10.1070.11">
        <property type="entry name" value="Phosphatidylinositol 3-/4-kinase, catalytic domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1010.10">
        <property type="entry name" value="Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011009">
        <property type="entry name" value="Kinase-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015433">
        <property type="entry name" value="PI3/4_kinase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000403">
        <property type="entry name" value="PI3/4_kinase_cat_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036940">
        <property type="entry name" value="PI3/4_kinase_cat_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018936">
        <property type="entry name" value="PI3/4_kinase_CS"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10048">
        <property type="entry name" value="PHOSPHATIDYLINOSITOL KINASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00454">
        <property type="entry name" value="PI3_PI4_kinase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00146">
        <property type="entry name" value="PI3Kc"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF56112">
        <property type="entry name" value="Protein kinase-like (PK-like)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00915">
        <property type="entry name" value="PI3_4_KINASE_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS00916">
        <property type="entry name" value="PI3_4_KINASE_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50290">
        <property type="entry name" value="PI3_4_KINASE_3"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2 5" id="KW-0418">Kinase</keyword>
    <keyword evidence="3" id="KW-0472">Membrane</keyword>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 5" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="145"/>
            <end position="165"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="3">
        <location>
            <begin position="217"/>
            <end position="236"/>
        </location>
    </feature>
    <feature type="domain" description="PI3K/PI4K catalytic" evidence="4">
        <location>
            <begin position="1840"/>
            <end position="2143"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022777"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="PROSITE" id="PS50290"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK89962.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="2158" mass="252631" checksum="B1676D6A6B18D1F8" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="89" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWX2</accession>
    <name>Q5CWX2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Microtubule-associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd6_3370</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89961.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627682.1">
        <property type="nucleotide sequence ID" value="XM_627682.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWX2"/>
    <dbReference type="FunCoup" id="Q5CWX2">
        <property type="interactions" value="212"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CWX2"/>
    <dbReference type="GeneID" id="3375706"/>
    <dbReference type="KEGG" id="cpv:cgd6_3370"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_3370"/>
    <dbReference type="InParanoid" id="Q5CWX2"/>
    <dbReference type="OMA" id="DHKYVEF"/>
    <dbReference type="OrthoDB" id="10261640at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.130.10.10">
        <property type="entry name" value="YVTN repeat-like/Quinoprotein amine dehydrogenase"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012972">
        <property type="entry name" value="NLE"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR015943">
        <property type="entry name" value="WD40/YVTN_repeat-like_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036322">
        <property type="entry name" value="WD40_repeat_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001680">
        <property type="entry name" value="WD40_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855:SF11">
        <property type="entry name" value="RIBOSOME BIOGENESIS PROTEIN WDR12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19855">
        <property type="entry name" value="WD40 REPEAT PROTEIN 12, 37"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08154">
        <property type="entry name" value="NLE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00400">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00320">
        <property type="entry name" value="WD40"/>
        <property type="match status" value="5"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50978">
        <property type="entry name" value="WD40 repeat-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50082">
        <property type="entry name" value="WD_REPEATS_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-0539">Nucleus</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0677">Repeat</keyword>
    <keyword evidence="2 5" id="KW-0853">WD repeat</keyword>
    <feature type="domain" description="NLE" evidence="6">
        <location>
            <begin position="15"/>
            <end position="78"/>
        </location>
    </feature>
    <feature type="repeat" description="WD" evidence="5">
        <location>
            <begin position="339"/>
            <end position="364"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022574"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022737"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00221"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF08154"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK89961.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="464" mass="51898" checksum="342CC4EFE8EEF9DC" modified="2007-04-03" version="1">MDNTMMEDKGDSQVEVFFWTKIKDPRLQAPEGSFMIDSKSGRAELSELLNTLLETENRIAFDFIIDEVFLRGTIYDYMRQNEKTSESKLKIEYLKTLGKPSIKILDKQKDWIRSITYGIETDNPMVVAGFYDGRIRFYDTISHKKDKKVKLDEDDNIRDNKSQTFEFNVNELLPEGDSTSVFRVQSQQLNDSEFSKVWASTMSGSIIGLSYSAKRQECILKSVKLKASIAPIEALCTVKGCDSIISAGDANGNVLVFCKESTDNGTLNNIENTNSLNCTAKIKIHSSNVTDILSLGDNLISSSLDGNIKVSKVSLGEAVCGWNIKFPTFSLSTQNSMVGNVICTSHDDGKVRIWDLRAGATSQIDLKAKKDMGLVSFDRNTRFVHRSRLLAHKEVVPQAVWSPYSEYMIGSVSHDMDLKILDIRSPNLPLQAAKTDSKLLSLCWMNEHTIYTGGSTGELIVCSF</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX43</accession>
    <name>Q5CX43_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd6_2580</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89900.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627611.1">
        <property type="nucleotide sequence ID" value="XM_627611.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX43"/>
    <dbReference type="GeneID" id="3376140"/>
    <dbReference type="KEGG" id="cpv:cgd6_2580"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2580"/>
    <dbReference type="InParanoid" id="Q5CX43"/>
    <dbReference type="OMA" id="QNVNKFP"/>
    <dbReference type="OrthoDB" id="341582at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="178"/>
            <end position="222"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="236"/>
            <end position="298"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="339"/>
            <end position="423"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="433"/>
            <end position="460"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="1">
        <location>
            <begin position="526"/>
            <end position="587"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="1"/>
            <end position="22"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="178"/>
            <end position="191"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="204"/>
            <end position="216"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="244"/>
            <end position="259"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="260"/>
            <end position="289"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="357"/>
            <end position="371"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="385"/>
            <end position="398"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="399"/>
            <end position="409"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK89900.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="927" mass="103716" checksum="3DBE5A13D54BAF8A" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="52" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX76</accession>
    <name>Q5CX76_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Leucine-rich repeats protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd6_2200</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89872.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627578.1">
        <property type="nucleotide sequence ID" value="XM_627578.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX76"/>
    <dbReference type="STRING" id="353152.Q5CX76"/>
    <dbReference type="GeneID" id="3376170"/>
    <dbReference type="KEGG" id="cpv:cgd6_2200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_2200"/>
    <dbReference type="InParanoid" id="Q5CX76"/>
    <dbReference type="OMA" id="DLEIMIV"/>
    <dbReference type="OrthoDB" id="550575at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0019005">
        <property type="term" value="C:SCF ubiquitin ligase complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031146">
        <property type="term" value="P:SCF-dependent proteasomal ubiquitin-dependent protein catabolic process"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.80.10.10">
        <property type="entry name" value="Ribonuclease Inhibitor"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR032675">
        <property type="entry name" value="LRR_dom_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13318">
        <property type="entry name" value="PARTNER OF PAIRED, ISOFORM B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52047">
        <property type="entry name" value="RNI-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK89872.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="621" mass="71996" checksum="D99793733B5A3658" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="79" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CX97</accession>
    <name>Q5CX97_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="12">Membrane-associated protein with a family 1 glycosyltransferase domain and a ricin domain with 3 transmembraned domains near C-terminus</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd6_1960</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="9">Endomembrane system</location>
            <topology evidence="9">Single-pass membrane protein</topology>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Single-pass type II membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89861.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627557.1">
        <property type="nucleotide sequence ID" value="XM_627557.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CX97"/>
    <dbReference type="STRING" id="353152.Q5CX97"/>
    <dbReference type="GeneID" id="3376073"/>
    <dbReference type="KEGG" id="cpv:cgd6_1960"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1960"/>
    <dbReference type="InParanoid" id="Q5CX97"/>
    <dbReference type="OMA" id="IHYTEIN"/>
    <dbReference type="OrthoDB" id="416652at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004653">
        <property type="term" value="F:polypeptide N-acetylgalactosaminyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006493">
        <property type="term" value="P:protein O-linked glycosylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd00161">
        <property type="entry name" value="beta-trefoil_Ricin-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd02510">
        <property type="entry name" value="pp-GalNAc-T"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.90.550.10">
        <property type="entry name" value="Spore Coat Polysaccharide Biosynthesis Protein SpsA, Chain A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045885">
        <property type="entry name" value="GalNAc-T"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001173">
        <property type="entry name" value="Glyco_trans_2-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR029044">
        <property type="entry name" value="Nucleotide-diphossugar_trans"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035992">
        <property type="entry name" value="Ricin_B-like_lectins"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11675:SF134">
        <property type="entry name" value="N-ACETYLGALACTOSAMINYLTRANSFERASE 4-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00535">
        <property type="entry name" value="Glycos_transf_2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53448">
        <property type="entry name" value="Nucleotide-diphospho-sugar transferases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50370">
        <property type="entry name" value="Ricin B-like lectins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50231">
        <property type="entry name" value="RICIN_B_LECTIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1015">Disulfide bond</keyword>
    <keyword evidence="8" id="KW-0325">Glycoprotein</keyword>
    <keyword evidence="6 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4" id="KW-0735">Signal-anchor</keyword>
    <keyword evidence="12" id="KW-0808">Transferase</keyword>
    <keyword evidence="3 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="5 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="18"/>
            <end position="35"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="41"/>
            <end position="60"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="122"/>
            <end position="141"/>
        </location>
    </feature>
    <feature type="domain" description="Glycosyltransferase 2-like" evidence="11">
        <location>
            <begin position="275"/>
            <end position="399"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004606"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005680"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022968"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023157"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023180"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00037847"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF00535"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK89861.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="809" mass="94527" checksum="331EF644F9BAE708" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="76" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXA8</accession>
    <name>Q5CXA8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">N-alpha-acetyltransferase 40</fullName>
            <ecNumber evidence="4">2.3.1.257</ecNumber>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="13" type="ORF">cgd6_1800</name>
    </gene>
    <organism evidence="13 14">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="13 14" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="14">Iowa II</strain>
        </source>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="10">
            <text>N-terminal L-seryl-[histone H2A] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H2A] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50600"/>
            <dbReference type="Rhea" id="RHEA-COMP:12742"/>
            <dbReference type="Rhea" id="RHEA-COMP:12744"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>N-terminal L-seryl-[histone H4] + acetyl-CoA = N-terminal N(alpha)-acetyl-L-seryl-[histone H4] + CoA + H(+)</text>
            <dbReference type="Rhea" id="RHEA:50596"/>
            <dbReference type="Rhea" id="RHEA-COMP:12740"/>
            <dbReference type="Rhea" id="RHEA-COMP:12743"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:57287"/>
            <dbReference type="ChEBI" id="CHEBI:57288"/>
            <dbReference type="ChEBI" id="CHEBI:64738"/>
            <dbReference type="ChEBI" id="CHEBI:83690"/>
            <dbReference type="EC" id="2.3.1.257"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Cytoplasm</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="3">Belongs to the acetyltransferase family. NAA40 subfamily.</text>
    </comment>
    <comment type="caution">
        <text evidence="13">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="2.3.1.257" evidence="4"/>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89847.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627546.1">
        <property type="nucleotide sequence ID" value="XM_627546.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXA8"/>
    <dbReference type="STRING" id="353152.Q5CXA8"/>
    <dbReference type="GeneID" id="3376126"/>
    <dbReference type="KEGG" id="cpv:cgd6_1800"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1800"/>
    <dbReference type="InParanoid" id="Q5CXA8"/>
    <dbReference type="OMA" id="AYLHYRF"/>
    <dbReference type="OrthoDB" id="424551at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0043998">
        <property type="term" value="F:histone H2A acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0010485">
        <property type="term" value="F:histone H4 acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990189">
        <property type="term" value="F:protein N-terminal-serine acetyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.630.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016181">
        <property type="entry name" value="Acyl_CoA_acyltransferase"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000182">
        <property type="entry name" value="GNAT_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR039949">
        <property type="entry name" value="NAA40"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR20531:SF1">
        <property type="entry name" value="N-ALPHA-ACETYLTRANSFERASE 40"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00583">
        <property type="entry name" value="Acetyltransf_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55729">
        <property type="entry name" value="Acyl-CoA N-acyltransferases (Nat)"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="9" id="KW-0012">Acyltransferase</keyword>
    <keyword evidence="6" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="14" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="7 13" id="KW-0808">Transferase</keyword>
    <feature type="domain" description="N-acetyltransferase" evidence="12">
        <location>
            <begin position="174"/>
            <end position="234"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00008870"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00012950"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00015043"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023315"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00047821"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049524"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="12">
        <source>
            <dbReference type="Pfam" id="PF00583"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="EMBL" id="EAK89847.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="14">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="255" mass="30069" checksum="A99D55CD34A02D27" modified="2005-04-12" version="1">MTQIIKNQKISRKKSIAISRKNKYKCLIKEIRKSKDFFLNLLQDKNLIYFKTELTKISNRSNLHIARRSDLSSTHMENILKITRDNMKILYDENPWGDIWSQGWDDHLKMNELCHNLSNYIIIYERNTDNATNTIMSTDCSSDISFHNDLRTDINILSFLSFRFELEDEFDSCNKHIIGYMYELQSLVKGKGYGRLLIDLLRFICNELQIYKIICTVLRKNVDAVRFYTKKCGFAIDETSPENEPYIILSTNTSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="71" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXB8</accession>
    <name>Q5CXB8_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="8">Nuclear cap-binding protein subunit 2</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="8">20 kDa nuclear cap-binding protein</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd6_1700</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1 8">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 8">Belongs to the RRM NCBP2 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89839.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627536.1">
        <property type="nucleotide sequence ID" value="XM_627536.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXB8"/>
    <dbReference type="FunCoup" id="Q5CXB8">
        <property type="interactions" value="222"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXB8"/>
    <dbReference type="GeneID" id="3376118"/>
    <dbReference type="KEGG" id="cpv:cgd6_1700"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1700"/>
    <dbReference type="InParanoid" id="Q5CXB8"/>
    <dbReference type="OMA" id="PNVQHMM"/>
    <dbReference type="OrthoDB" id="201398at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005846">
        <property type="term" value="C:nuclear cap binding complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000339">
        <property type="term" value="F:RNA cap binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0045292">
        <property type="term" value="P:mRNA cis splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd12240">
        <property type="entry name" value="RRM_NCBP2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.330">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027157">
        <property type="entry name" value="NCBP2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR034148">
        <property type="entry name" value="NCBP2_RRM"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012677">
        <property type="entry name" value="Nucleotide-bd_a/b_plait_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR035979">
        <property type="entry name" value="RBD_domain_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000504">
        <property type="entry name" value="RRM_dom"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847">
        <property type="entry name" value="20 KD NUCLEAR CAP BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR18847:SF0">
        <property type="entry name" value="NUCLEAR CAP-BINDING PROTEIN SUBUNIT 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00076">
        <property type="entry name" value="RRM_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00360">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54928">
        <property type="entry name" value="RNA-binding domain, RBD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50102">
        <property type="entry name" value="RRM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3 8" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="5 8" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="6 8" id="KW-0539">Nucleus</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 7 8" id="KW-0694">RNA-binding</keyword>
    <feature type="domain" description="RRM" evidence="10">
        <location>
            <begin position="33"/>
            <end position="111"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="156"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="9">
        <location>
            <begin position="165"/>
            <end position="176"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00010725"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00176"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="RuleBase" id="RU364036"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="10">
        <source>
            <dbReference type="PROSITE" id="PS50102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK89839.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="213" mass="24705" checksum="59C55F8C5E9D493C" modified="2007-04-03" version="1">MSYLFHAIGHEYSYFDKKNYSKDDWIAKISKSTTVYVGNLSFFTTEEIISEVFGLCGPIKAIYLGLNHQTMQPCGFCFVQYYSHADALTAVTFLNRSYCDGREIRVDWDSGEDISGSRRYGRGNSGFQWRDELRNQIDPDRQLDVVDTNNHSKSYKFSHGSNSSFHRRHPGGRGRNSRGTFNISHYNRQIKHKHQVFDQLKNTNGSHDNYPDY</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXC2</accession>
    <name>Q5CXC2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd6_1660</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Secreted</location>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89835.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627532.1">
        <property type="nucleotide sequence ID" value="XM_627532.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXC2"/>
    <dbReference type="STRING" id="353152.Q5CXC2"/>
    <dbReference type="GeneID" id="3376114"/>
    <dbReference type="KEGG" id="cpv:cgd6_1660"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1660"/>
    <dbReference type="InParanoid" id="Q5CXC2"/>
    <dbReference type="OrthoDB" id="6090599at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031012">
        <property type="term" value="C:extracellular matrix"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005576">
        <property type="term" value="C:extracellular region"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004222">
        <property type="term" value="F:metalloendopeptidase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0030198">
        <property type="term" value="P:extracellular matrix organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006508">
        <property type="term" value="P:proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.20.100.10">
        <property type="entry name" value="Thrombospondin type-1 (TSP1) repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050439">
        <property type="entry name" value="ADAMTS_ADAMTS-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000884">
        <property type="entry name" value="TSP1_rpt"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036383">
        <property type="entry name" value="TSP1_rpt_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723">
        <property type="entry name" value="ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13723:SF281">
        <property type="entry name" value="PAPILIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00090">
        <property type="entry name" value="TSP_1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00209">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF82895">
        <property type="entry name" value="TSP-1 type 1 repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50092">
        <property type="entry name" value="TSP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2" id="KW-0964">Secreted</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="27"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254598" evidence="3">
        <location>
            <begin position="28"/>
            <end position="1126"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022525"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK89835.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1126" mass="129162" checksum="0ECA0E432467F708" modified="2007-04-03" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2026-01-28" version="46" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXD7</accession>
    <name>Q5CXD7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Cytoachrome c oxidase subunit III with 6 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_1500</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90113.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627517.1">
        <property type="nucleotide sequence ID" value="XM_627517.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXD7"/>
    <dbReference type="GeneID" id="3375858"/>
    <dbReference type="KEGG" id="cpv:cgd6_1500"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_1500"/>
    <dbReference type="InParanoid" id="Q5CXD7"/>
    <dbReference type="OMA" id="DDACWAR"/>
    <dbReference type="OrthoDB" id="396938at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR021691">
        <property type="entry name" value="DUF3273"/>
    </dbReference>
    <dbReference type="Pfam" id="PF11677">
        <property type="entry name" value="DUF3273"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 2" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="36"/>
            <end position="54"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="76"/>
            <end position="98"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="119"/>
            <end position="137"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="157"/>
            <end position="181"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="193"/>
            <end position="213"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="219"/>
            <end position="238"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90113.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="291" mass="32043" checksum="4B7B7D23ECAF1C32" modified="2007-04-03" version="1">MWLSTRVENVDTGIATKQGPSIPIEGMFNTLLRMGLLFELMCYLGLTMISYNYTNQLSFNYHSLGEILVQGNAPKYISFCFFLGIMGSLHLMSFQLLLADDTCFARGYVTGSKIIKIATLLDFIGKTIGFVFTMQLGGSTDLESAFNMAVAQGGVEINFLTFGQILCGIAFVSYGLGFLLLELFQDEGVGNSYGYINFLAFSASGASLLLHATTFKCTGATLFALTSFSTALLWALLFEPSINEFSPAFGETELTNDVETQVEKFTRTNQYYNVDENYGSYSQQPSSGYMN</sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="73" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXJ6</accession>
    <name>Q5CXJ6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">Shanti/Ykl100cp/Minor histocompatibility antigen H13-like protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd6_840</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the peptidase A22B family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK89773.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627458.1">
        <property type="nucleotide sequence ID" value="XM_627458.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXJ6"/>
    <dbReference type="FunCoup" id="Q5CXJ6">
        <property type="interactions" value="366"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXJ6"/>
    <dbReference type="MEROPS" id="A22.013"/>
    <dbReference type="GeneID" id="3376083"/>
    <dbReference type="KEGG" id="cpv:cgd6_840"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_840"/>
    <dbReference type="InParanoid" id="Q5CXJ6"/>
    <dbReference type="OMA" id="FLYDIWW"/>
    <dbReference type="OrthoDB" id="29661at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098554">
        <property type="term" value="C:cytoplasmic side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0098553">
        <property type="term" value="C:lumenal side of endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0042500">
        <property type="term" value="F:aspartic endopeptidase activity, intramembrane cleaving"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0033619">
        <property type="term" value="P:membrane protein proteolysis"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006465">
        <property type="term" value="P:signal peptide processing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR007369">
        <property type="entry name" value="Peptidase_A22B_SPP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006639">
        <property type="entry name" value="Preselin/SPP"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174:SF23">
        <property type="entry name" value="MINOR HISTOCOMPATIBILITY ANTIGEN H13"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12174">
        <property type="entry name" value="SIGNAL PEPTIDE PEPTIDASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF04258">
        <property type="entry name" value="Peptidase_A22B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00730">
        <property type="entry name" value="PSN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="4" id="KW-0378">Hydrolase</keyword>
    <keyword evidence="7 9" id="KW-0472">Membrane</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 9" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="6 9" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="12"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="35"/>
            <end position="59"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="80"/>
            <end position="99"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="111"/>
            <end position="133"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="172"/>
            <end position="190"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="196"/>
            <end position="214"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="221"/>
            <end position="245"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="265"/>
            <end position="288"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="309"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="9">
        <location>
            <begin position="339"/>
            <end position="357"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="8">
        <location>
            <begin position="366"/>
            <end position="408"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="374"/>
            <end position="390"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="8">
        <location>
            <begin position="397"/>
            <end position="408"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004477"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006859"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022801"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK89773.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="408" mass="45989" checksum="49A847AB792873B2" modified="2007-04-03" version="1">MGQACCNKSLMAYCLSYLVLALAILITNFKPLPIIVQMLMYTSSIIYIGSYLSLSQTIIDPKTGEKDRSTESLSRKDAMMFPVIGSVALFSLYLAYKFLPVYWVNLLLTSYLFIIGAVALMETILQFISIVIYKCDDICKDTKLIIVDTHFNFFGYFENPDDPRGHEIKITIHHLWSLALSLALGIIWIITDSWIIHNLFAIAFCIQAISLISIGSFKIGAILLCGLFVYDIFWVFGTDVMVTVAKSFQGPAKLIFPVSFDPWKQSILGLGDIVIPGLFISLCLRFDLKDYTKKHNQSLYHLISSSLQTPTFCTVLVSYLLGLITTACVMLYFKAAQPALLYLVPFCLISMVLSVVYRNKSSDAWNYSEEADSDERINDSKESSEEDKSQSKTSTRKKSDVLKQKKDD</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="61" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXQ8</accession>
    <name>Q5CXQ8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="3">Hedgehog-type HINT domain protein, possible animal horizontal transfer, signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_5290</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90482.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628672.1">
        <property type="nucleotide sequence ID" value="XM_628670.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXQ8"/>
    <dbReference type="STRING" id="353152.Q5CXQ8"/>
    <dbReference type="GeneID" id="3372100"/>
    <dbReference type="KEGG" id="cpv:cgd7_5290"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5290"/>
    <dbReference type="InParanoid" id="Q5CXQ8"/>
    <dbReference type="OMA" id="NCYANSE"/>
    <dbReference type="OrthoDB" id="5212at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016539">
        <property type="term" value="P:intein-mediated protein splicing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016540">
        <property type="term" value="P:protein autoprocessing"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd00081">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.170.16.10">
        <property type="entry name" value="Hedgehog/Intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001767">
        <property type="entry name" value="Hedgehog_Hint"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050387">
        <property type="entry name" value="Hedgehog_Signaling"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR003587">
        <property type="entry name" value="Hint_dom_N"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036844">
        <property type="entry name" value="Hint_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006141">
        <property type="entry name" value="Intein_N"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11889">
        <property type="entry name" value="HEDGEHOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11889:SF31">
        <property type="entry name" value="PROTEIN HEDGEHOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01079">
        <property type="entry name" value="Hint"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00306">
        <property type="entry name" value="HintN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF51294">
        <property type="entry name" value="Hedgehog/intein (Hint) domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50817">
        <property type="entry name" value="INTEIN_N_TER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254616" evidence="1">
        <location>
            <begin position="21"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="domain" description="Hint" evidence="2">
        <location>
            <begin position="115"/>
            <end position="250"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="2">
        <source>
            <dbReference type="SMART" id="SM00306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90482.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="376" mass="43055" checksum="1960F0AE6A851B98" modified="2005-04-12" version="1">MKVNNIKIICFLWLTILVELFWFNKESRKNVDLFHSNLSFIRVRTKSIFDTFSGMSAGGTGFRSGWGNVISNAISLAFPSSCVGQLINIGYLSNELDEDDYPYNPNCGAQSQSNNLCFPGNSLVITRERGEIKLEDLRIGEYVLIRDLNTMKFKYSKVEIMLHKDKNIYLDDEWIQVEYLGMEKPLVLSPNHLIFIQYLGEKPHEGNCYYPSQIEKAIGIEVTPQLEKKKKLTSIQAKDIRVGDSVIIYSKERVGWVTQVSIISNVNSNQKNYEYVGRYAPLTTDGYLIVNGVLVSSYSKPFPWPMELLNPSHNLIDLLARPIVNIEIHFKQIFDYTRNGVVKILRYISNISSKYTFDQSIALSLEIIRAISLFVK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="80" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXT1</accession>
    <name>Q5CXT1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="5">Putative 40S ribosomal protein S20</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="5" type="ORF">cgd7_5060</name>
    </gene>
    <organism evidence="5 6">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="5 6" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="6">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the universal ribosomal protein uS10 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="5">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90652.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628649.1">
        <property type="nucleotide sequence ID" value="XM_628647.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXT1"/>
    <dbReference type="FunCoup" id="Q5CXT1">
        <property type="interactions" value="301"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CXT1"/>
    <dbReference type="GeneID" id="3371955"/>
    <dbReference type="KEGG" id="cpv:cgd7_5060"/>
    <dbReference type="InParanoid" id="Q5CXT1"/>
    <dbReference type="OMA" id="IHKRVIH"/>
    <dbReference type="OrthoDB" id="10248551at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0015935">
        <property type="term" value="C:small ribosomal subunit"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006412">
        <property type="term" value="P:translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.70.600:FF:000002">
        <property type="entry name" value="40S ribosomal protein S20"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.70.600">
        <property type="entry name" value="Ribosomal protein S10 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00508">
        <property type="entry name" value="Ribosomal_uS10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001848">
        <property type="entry name" value="Ribosomal_uS10"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR027486">
        <property type="entry name" value="Ribosomal_uS10_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036838">
        <property type="entry name" value="Ribosomal_uS10_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005729">
        <property type="entry name" value="Ribosomal_uS10_euk/arc"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR01046">
        <property type="entry name" value="uS10_euk_arch"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11700">
        <property type="entry name" value="30S RIBOSOMAL PROTEIN S10 FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00338">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00971">
        <property type="entry name" value="RIBOSOMALS10"/>
    </dbReference>
    <dbReference type="SMART" id="SM01403">
        <property type="entry name" value="Ribosomal_S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF54999">
        <property type="entry name" value="Ribosomal protein S10"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="6" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 5" id="KW-0689">Ribosomal protein</keyword>
    <feature type="domain" description="Small ribosomal subunit protein uS10" evidence="4">
        <location>
            <begin position="37"/>
            <end position="131"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="5">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007102"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="4">
        <source>
            <dbReference type="SMART" id="SM01403"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="EMBL" id="EAK90652.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="135" mass="15271" checksum="9701BF6013EC51C2" modified="2005-04-12" version="1" fragment="single">NRERSQSKMSAAVMKPTDKQFGQFNGEQQQAPLHKIRITLSSKNLKSIERVCADLIQSAKQKDLKVTGPVRMPVKTLRITTRKSPCGEGSKTWDRYEMRIYKRVIDLYSSSDVVKQITSINIDAGVEVEVTISDI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="38" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXT3</accession>
    <name>Q5CXT3_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized low complexity protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_5030</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90464.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628647.1">
        <property type="nucleotide sequence ID" value="XM_628645.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXT3"/>
    <dbReference type="GeneID" id="3372082"/>
    <dbReference type="KEGG" id="cpv:cgd7_5030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_5030"/>
    <dbReference type="InParanoid" id="Q5CXT3"/>
    <dbReference type="OMA" id="ISNINHW"/>
    <dbReference type="OrthoDB" id="1918at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR014848">
        <property type="entry name" value="Rgp1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12507">
        <property type="entry name" value="REDUCED GROWTH PHENOTYPE 1 RGP1, YEAST -RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08737">
        <property type="entry name" value="Rgp1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90464.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="593" mass="68689" checksum="FFCBA63B41B4292B" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CXY8</accession>
    <name>Q5CXY8_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Conserved protein with YSHH motif. SOme fused to polo box</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4410</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90416.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628592.1">
        <property type="nucleotide sequence ID" value="XM_628590.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CXY8"/>
    <dbReference type="STRING" id="353152.Q5CXY8"/>
    <dbReference type="GeneID" id="3372170"/>
    <dbReference type="KEGG" id="cpv:cgd7_4410"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4410"/>
    <dbReference type="InParanoid" id="Q5CXY8"/>
    <dbReference type="OMA" id="YMEITIE"/>
    <dbReference type="OrthoDB" id="432412at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="CDD" id="cd24163">
        <property type="entry name" value="RWDD2_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR017359">
        <property type="entry name" value="Phi-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010541">
        <property type="entry name" value="Prp3_C"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR059181">
        <property type="entry name" value="RWDD2A-B_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955">
        <property type="entry name" value="RWD DOMAIN CONTAINING PROTEIN 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15955:SF8">
        <property type="entry name" value="RWD DOMAIN-CONTAINING PROTEIN 2B-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06544">
        <property type="entry name" value="Prp3_C"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Small nuclear ribonucleoprotein Prp3 C-terminal" evidence="1">
        <location>
            <begin position="199"/>
            <end position="260"/>
        </location>
    </feature>
    <evidence type="ECO:0000259" key="1">
        <source>
            <dbReference type="Pfam" id="PF06544"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90416.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="325" mass="37482" checksum="986B76CB1B04A0EE" modified="2005-04-12" version="1">MNINIYENEAERLKQEIGALRCIFSEKDEMVVNKELESWLEQEVSNEGSHGDLRFRVLLGDRKFYSMPLYLEITLDPDNNYKSGLKKVSIVATKEWDGDNKRPFFLSESQTKYIEDVGINAFIPNMECIYDQVIASREATEDIVRDIPCEVLNSSLDSEMQSISSESESESSVLEQEEMIKYVWNTSGTSGTIKWGQRACYSHHIRSKIKRRLIVEWAKELCLGGYCKIGYPGIIIVEGLEDCCLEYTRRLQRLRWKHFIVRGEIIKDVSIDKNCTINLDTINSLRILPNTMIELPSDGTKILARICEDLGIKDLFLTTMKIYSK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY02</accession>
    <name>Q5CY02_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="2">Prohibitin</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd7_4240</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="2">Mitochondrion inner membrane</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="1 2">Belongs to the prohibitin family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90642.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628578.1">
        <property type="nucleotide sequence ID" value="XM_628576.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY02"/>
    <dbReference type="FunCoup" id="Q5CY02">
        <property type="interactions" value="305"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CY02"/>
    <dbReference type="GeneID" id="3371945"/>
    <dbReference type="KEGG" id="cpv:cgd7_4240"/>
    <dbReference type="InParanoid" id="Q5CY02"/>
    <dbReference type="OMA" id="YEFRLVT"/>
    <dbReference type="OrthoDB" id="275637at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005743">
        <property type="term" value="C:mitochondrial inner membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007005">
        <property type="term" value="P:mitochondrion organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd03401">
        <property type="entry name" value="SPFH_prohibitin"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.479.30:FF:000001">
        <property type="entry name" value="Prohibitin 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.479.30">
        <property type="entry name" value="Band 7 domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001107">
        <property type="entry name" value="Band_7"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036013">
        <property type="entry name" value="Band_7/SPFH_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000163">
        <property type="entry name" value="Prohibitin"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222">
        <property type="entry name" value="PROHIBITIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR23222:SF0">
        <property type="entry name" value="PROHIBITIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01145">
        <property type="entry name" value="Band_7"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00679">
        <property type="entry name" value="PROHIBITIN"/>
    </dbReference>
    <dbReference type="SMART" id="SM00244">
        <property type="entry name" value="PHB"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF117892">
        <property type="entry name" value="Band 7/SPFH domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="2" id="KW-0472">Membrane</keyword>
    <keyword evidence="2" id="KW-0496">Mitochondrion</keyword>
    <keyword evidence="2" id="KW-0999">Mitochondrion inner membrane</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Band 7" evidence="3">
        <location>
            <begin position="48"/>
            <end position="210"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="4">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00009658"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="RuleBase" id="RU366048"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="3">
        <source>
            <dbReference type="SMART" id="SM00244"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK90642.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="294" mass="33143" checksum="27A6AC6E3CBE0393" modified="2005-04-12" version="1" fragment="single">IVTAKSRLNGHVNEKLSKRTNMNVERILTRIARGGLLLGAIGTIPMSFMFNVDGGEKAIMFNRFGGGVSPKAISEGTHFFLPWFQVPFIYDVRVKPKVINTTTGTKDLQMVNLSLRLLFKPCTEFLPRLHQNLGPDYDEKVLPSVGNEILKAVVAKYDAESLLTQREKVSREIRESIMQRTKQFDIIMEDVAITHLTYGKEFEKAIEEKQVAQQDAERVKFVVQKAEYEKQAAIIRASGEAQAAEMISKAVSNSGWGIVDVRRLDGARDIIENLSKSDRVTLIQGDQQHLHFRV</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="55" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY15</accession>
    <name>Q5CY15_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Alpha superhelical protein, divergent TPR like repeats, possible microtubule associated protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_4090</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90392.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628565.1">
        <property type="nucleotide sequence ID" value="XM_628563.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY15"/>
    <dbReference type="GeneID" id="3372068"/>
    <dbReference type="KEGG" id="cpv:cgd7_4090"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_4090"/>
    <dbReference type="InParanoid" id="Q5CY15"/>
    <dbReference type="OMA" id="HNSIIRI"/>
    <dbReference type="OrthoDB" id="63891at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005881">
        <property type="term" value="C:cytoplasmic microtubule"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0008017">
        <property type="term" value="F:microtubule binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000226">
        <property type="term" value="P:microtubule cytoskeleton organization"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.10.10">
        <property type="entry name" value="Leucine-rich Repeat Variant"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011989">
        <property type="entry name" value="ARM-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016024">
        <property type="entry name" value="ARM-type_fold"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567">
        <property type="entry name" value="CLASP"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR21567:SF87">
        <property type="entry name" value="CRESCERIN-LIKE PROTEIN CHE-12"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48371">
        <property type="entry name" value="ARM repeat"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="368"/>
            <end position="392"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="368"/>
            <end position="385"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90392.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="691" mass="78134" checksum="FE6FDAC785DA337F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="35" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY33</accession>
    <name>Q5CY33_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3850</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90378.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628547.1">
        <property type="nucleotide sequence ID" value="XM_628545.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY33"/>
    <dbReference type="GeneID" id="3372133"/>
    <dbReference type="KEGG" id="cpv:cgd7_3850"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3850"/>
    <dbReference type="InParanoid" id="Q5CY33"/>
    <dbReference type="OMA" id="HYAHEET"/>
    <dbReference type="OrthoDB" id="336649at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90378.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="237" mass="26690" checksum="400F15CD0BD4407B" modified="2005-04-12" version="1">MEFSCQNSQTQICRRAYIPNYSKDEVKDLIGCNNTEEPNDSIKRNVGGFRYDLCSEKIYKIFQASNWKNDNVSKKNYNHEETPKVGQVSLKRSIVYDSSLGCCVPLYTRKPGCSRMKLDIIGYGESENYGTQLERASDNSMGTILNNSNLHKNFNQHFSGCSTNIIGEIRDSFGRLPSKAGYKTSKVNKSSVHIENDFYMPEEGSSYENNTKTQHSVGKNFNGSHLTFSGGFLTSIS</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="51" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY41</accession>
    <name>Q5CY41_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="5">Heat shock factor binding protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="3" type="ORF">cgd7_3770</name>
    </gene>
    <organism evidence="3 4">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="3 4" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="4">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the HSBP1 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="3">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90370.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628539.1">
        <property type="nucleotide sequence ID" value="XM_628537.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY41"/>
    <dbReference type="GeneID" id="3372125"/>
    <dbReference type="KEGG" id="cpv:cgd7_3770"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3770"/>
    <dbReference type="InParanoid" id="Q5CY41"/>
    <dbReference type="OMA" id="MQSRFET"/>
    <dbReference type="OrthoDB" id="4159489at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005829">
        <property type="term" value="C:cytosol"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003714">
        <property type="term" value="F:transcription corepressor activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0070370">
        <property type="term" value="P:cellular heat acclimation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.20.5.430">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR009643">
        <property type="entry name" value="HS1-bd"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR19424:SF0">
        <property type="entry name" value="HEAT SHOCK FACTOR BINDING PROTEIN 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF06825">
        <property type="entry name" value="HSBP1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="1"/>
            <end position="28"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="76"/>
            <end position="112"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="2">
        <location>
            <begin position="76"/>
            <end position="91"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00006349"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="EMBL" id="EAK90370.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="5">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="112" mass="12720" checksum="CE83DA45F0C6A0A1" modified="2005-04-12" version="1">MDTISNINTENDSSQQANISHSNVEESTQSLKFVMQDVQEHFKRASQTILSRIDEMGSRIDQLEFMLNDLISEVESSSPMKQKTAHNQNDLNHSKAEVNDLIPIESTEQVNK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="34" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY80</accession>
    <name>Q5CY80_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Hypothetical low complexity protein perhaps membrane associated</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3360</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90335.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628500.1">
        <property type="nucleotide sequence ID" value="XM_628498.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY80"/>
    <dbReference type="GeneID" id="3372050"/>
    <dbReference type="KEGG" id="cpv:cgd7_3360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3360"/>
    <dbReference type="InParanoid" id="Q5CY80"/>
    <dbReference type="OMA" id="CSERTIY"/>
    <dbReference type="OrthoDB" id="339433at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90335.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="831" mass="97292" checksum="6FDD07C48F676704" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="45" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CY93</accession>
    <name>Q5CY93_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">t-SNARE coiled-coil homology domain-containing protein</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_3220</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa type II</strain>
        </source>
    </reference>
    <reference evidence="2" key="2">
        <citation type="submission" date="2007-02" db="EMBL/GenBank/DDBJ databases">
            <authorList>
                <consortium name="CryptoDB"/>
            </authorList>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE</scope>
        <source>
            <strain evidence="2">Iowa type II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90327.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628487.1">
        <property type="nucleotide sequence ID" value="XM_628485.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CY93"/>
    <dbReference type="GeneID" id="3372300"/>
    <dbReference type="KEGG" id="cpv:cgd7_3220"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3220"/>
    <dbReference type="InParanoid" id="Q5CY93"/>
    <dbReference type="OMA" id="CEIEAYC"/>
    <dbReference type="OrthoDB" id="341081at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0472">Membrane</keyword>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="1" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="1">
        <location>
            <begin position="255"/>
            <end position="273"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90327.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0008006" key="4">
        <source>
            <dbReference type="Google" id="ProtNLM"/>
        </source>
    </evidence>
    <sequence length="277" mass="32591" checksum="9693AF40E9A18CDB" modified="2005-04-12" version="1">MDWKYTRGFNEIEDLLKRVKHIELLCESDVKIDEVSSIEQEYIKHKIKLFELYNTTYTILDHLENDENHPKLLTKIKLVDLISQMKIEIRELRKIYNKYSSSLRINQLNKDDNKYIDIENYEKEFIEITESRFNKLFTDPFSKITHSTTLNDFLLKPDSANKVEHREIGDSDKTKINEWSLENRRIDEDIKEVGNMALRIADKAAQLGREAKAHNISIEEIKNTTEFATTDIFNLNRKVQEVIGTNNNTTFCCRITLVTLVFISVSLIIVLIFKKLI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYB2</accession>
    <name>Q5CYB2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="1">Cysteine-rich protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="1" type="ORF">cgd7_3010</name>
    </gene>
    <organism evidence="1 2">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="1 2" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="2">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="1">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90310.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628468.1">
        <property type="nucleotide sequence ID" value="XM_628466.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYB2"/>
    <dbReference type="STRING" id="353152.Q5CYB2"/>
    <dbReference type="GeneID" id="3372283"/>
    <dbReference type="KEGG" id="cpv:cgd7_3010"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_3010"/>
    <dbReference type="InParanoid" id="Q5CYB2"/>
    <dbReference type="OMA" id="YNTSAIC"/>
    <dbReference type="OrthoDB" id="342989at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="2" id="KW-1185">Reference proteome</keyword>
    <evidence type="ECO:0000313" key="1">
        <source>
            <dbReference type="EMBL" id="EAK90310.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="204" mass="22396" checksum="B7EEF214C363A117" modified="2005-04-12" version="1">MPSNNICSPITNSNDENSNALISSGCKSTDCHCEGNGVVTTHTTSPNVTQKCYITNSGCHEAIVTTTTQEVKRHKCPPKIQKIHEHISQPINYNCSSQLGNVPCNIMMNPCACSVSRSSCHRTNHCNCSNGSVQFMCCNKYANSGCGCSCCCCSTSSVQTTLYPVYMSFPYNQGRNINVPYTVYSTPLSHTYNPLTDNQYSYQY</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYF0</accession>
    <name>Q5CYF0_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Integral membrane protein with 10 transmembrane domains</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_2590</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90277.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628430.1">
        <property type="nucleotide sequence ID" value="XM_628428.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYF0"/>
    <dbReference type="GeneID" id="3371925"/>
    <dbReference type="KEGG" id="cpv:cgd7_2590"/>
    <dbReference type="InParanoid" id="Q5CYF0"/>
    <dbReference type="OMA" id="IMLHEEK"/>
    <dbReference type="OrthoDB" id="343005at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0016020">
        <property type="term" value="C:membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR037185">
        <property type="entry name" value="EmrE-like"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004853">
        <property type="entry name" value="Sugar_P_trans_dom"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR050186">
        <property type="entry name" value="TPT_transporter"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11132">
        <property type="entry name" value="SOLUTE CARRIER FAMILY 35"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03151">
        <property type="entry name" value="TPT"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF103481">
        <property type="entry name" value="Multidrug resistance efflux transporter EmrE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="4 5" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="2 5 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="3 5" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="12"/>
            <end position="37"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="57"/>
            <end position="83"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="235"/>
            <end position="253"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="259"/>
            <end position="280"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="289"/>
            <end position="310"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="316"/>
            <end position="337"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="349"/>
            <end position="376"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="436"/>
            <end position="453"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="5">
        <location>
            <begin position="504"/>
            <end position="523"/>
        </location>
    </feature>
    <feature type="domain" description="Sugar phosphate transporter" evidence="6">
        <location>
            <begin position="232"/>
            <end position="450"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="6">
        <source>
            <dbReference type="Pfam" id="PF03151"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90277.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="541" mass="59595" checksum="ACCCD544F0F471A0" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="67" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYG5</accession>
    <name>Q5CYG5_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="4">Large ribosomal subunit protein eL22</fullName>
        </recommendedName>
        <alternativeName>
            <fullName evidence="5">60S ribosomal protein L22</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="6" type="ORF">cgd7_2420</name>
    </gene>
    <organism evidence="6 7">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="6 7" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="7">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="1">Belongs to the eukaryotic ribosomal protein eL22 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="6">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90263.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628415.1">
        <property type="nucleotide sequence ID" value="XM_628413.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYG5"/>
    <dbReference type="FunCoup" id="Q5CYG5">
        <property type="interactions" value="291"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYG5"/>
    <dbReference type="GeneID" id="3372212"/>
    <dbReference type="KEGG" id="cpv:cgd7_2420"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2420"/>
    <dbReference type="InParanoid" id="Q5CYG5"/>
    <dbReference type="OMA" id="YQLRFYN"/>
    <dbReference type="OrthoDB" id="10259820at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005737">
        <property type="term" value="C:cytoplasm"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-ARBA"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990904">
        <property type="term" value="C:ribonucleoprotein complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005840">
        <property type="term" value="C:ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003735">
        <property type="term" value="F:structural constituent of ribosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0002181">
        <property type="term" value="P:cytoplasmic translation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.1360.210:FF:000001">
        <property type="entry name" value="60S ribosomal protein L22 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.1360.210">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002671">
        <property type="entry name" value="Ribosomal_eL22"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR038526">
        <property type="entry name" value="Ribosomal_eL22_sf"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064">
        <property type="entry name" value="60S RIBOSOMAL PROTEIN L22"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10064:SF0">
        <property type="entry name" value="FI24544P1-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01776">
        <property type="entry name" value="Ribosomal_L22e"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="2 6" id="KW-0689">Ribosomal protein</keyword>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00007817"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00022980"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00040613"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00041214"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="6">
        <source>
            <dbReference type="EMBL" id="EAK90263.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="115" mass="13244" checksum="BD2C7909F3A9171A" modified="2005-04-12" version="1">MAPITKAHKTQRFIVDCTAPMQDNIIDASGLEKFFHDRIKVDGKCGQLGTKIQISRQKGRITVLSEVPMSKRYLKYLTKKYLKKQQIRDFLRVVATSKGSYEVRYFNISNEAGEE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYH1</accession>
    <name>Q5CYH1_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="7">Eukaryotic membrane protein with transmembrane domains near C-and N-regions</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="7" type="ORF">cgd7_2360</name>
    </gene>
    <organism evidence="7 8">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="7 8" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="8">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Membrane</location>
            <topology evidence="1">Multi-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the CDC50/LEM3 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="7">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90259.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628409.1">
        <property type="nucleotide sequence ID" value="XM_628407.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYH1"/>
    <dbReference type="GeneID" id="3372208"/>
    <dbReference type="KEGG" id="cpv:cgd7_2360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2360"/>
    <dbReference type="InParanoid" id="Q5CYH1"/>
    <dbReference type="OMA" id="ESERWHI"/>
    <dbReference type="OrthoDB" id="340608at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005783">
        <property type="term" value="C:endoplasmic reticulum"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005794">
        <property type="term" value="C:Golgi apparatus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005886">
        <property type="term" value="C:plasma membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR005045">
        <property type="entry name" value="CDC50/LEM3_fam"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926:SF0">
        <property type="entry name" value="CDC50, ISOFORM A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10926">
        <property type="entry name" value="CELL CYCLE CONTROL PROTEIN 50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03381">
        <property type="entry name" value="CDC50"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5 6" id="KW-0472">Membrane</keyword>
    <keyword evidence="8" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3 6 7" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="4 6" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="109"/>
            <end position="125"/>
        </location>
    </feature>
    <feature type="transmembrane region" description="Helical" evidence="6">
        <location>
            <begin position="428"/>
            <end position="448"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004141"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00009457"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="7">
        <source>
            <dbReference type="EMBL" id="EAK90259.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="465" mass="54879" checksum="1698C1AB5F12CF6C" modified="2005-04-12" version="1">MEQIKDEIFFKKDECWKESEKKFLENEWRNSKGSLESIVSSNSPNNSAFTVRSKLSQDSHSDEYSVMIDDDAPVDEEIYFQFSDISIINRVFCDISSVKYTTYSEIKHIFYFLSFFFFILSIFLFERSWNGVTKVKVYYDNFGNFPLLFKNNEYSSNLSEIEYENISENSKLYEFTVDRTLQEPIFVFYGINGFFSNTKEFVGSKPPEIFGYGYKCTHILSIDDILRYRPDFRIHLAEFFRVPINFNFTQIDSIFSNNKKSRIFKMSKKNNSINRNILCGLPIYSLFTDEFELTKKGSSKEKIQIRAIDFPEDQWKYKMLHSFRQFISGAINSKFLNQSHRYEKKSNDKIPKLSMMLSRWWSQSISPNFIKPYGIISSSYEYSSMEDMILYPGSYELHFISNLFPNNAWGAEKYVLFMNLSVFGGEQYLAAVICLFIAIVYALIIYFNPKRAQIIIIKNRIDQNI</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="36" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYI6</accession>
    <name>Q5CYI6_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_2200</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90248.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628394.1">
        <property type="nucleotide sequence ID" value="XM_628392.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYI6"/>
    <dbReference type="GeneID" id="3371896"/>
    <dbReference type="KEGG" id="cpv:cgd7_2200"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_2200"/>
    <dbReference type="InParanoid" id="Q5CYI6"/>
    <dbReference type="OrthoDB" id="343179at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="1">
        <location>
            <begin position="1"/>
            <end position="20"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254648" evidence="1">
        <location>
            <begin position="21"/>
            <end position="198"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90248.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="198" mass="22744" checksum="2D5E4B6D55BCF8D4" modified="2005-04-12" version="1">MRSILFYFILLFYPISTSLGKESELFWKVKTNLILTTDARFEGAQLCTSLEDELMENAEGSDIKYEENNALDYNLNSNNMIELVVTNSKEEEVTLFVTDAVYNLIYKKKDLRKNPSIFHRPKFSESTDEYQNNNVSQEVEPTGRIVYIKKYYSPDGANKHLPVIQKFNYSNIQFSINSSSVSVSAMNTFNFTNGSGNE</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2026-01-28" version="70" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYM2</accession>
    <name>Q5CYM2_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="11">ALG1 like beta-1,4 mannosyltransferase with possible signal peptide</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="11" type="ORF">cgd7_1810</name>
    </gene>
    <organism evidence="11 12">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="11 12" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="12">Iowa II</strain>
        </source>
    </reference>
    <comment type="pathway">
        <text evidence="2">Protein modification; protein glycosylation.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Endoplasmic reticulum membrane</location>
            <topology evidence="1">Single-pass membrane protein</topology>
        </subcellularLocation>
    </comment>
    <comment type="caution">
        <text evidence="11">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90222.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628358.1">
        <property type="nucleotide sequence ID" value="XM_628356.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYM2"/>
    <dbReference type="STRING" id="353152.Q5CYM2"/>
    <dbReference type="GeneID" id="3371742"/>
    <dbReference type="KEGG" id="cpv:cgd7_1810"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1810"/>
    <dbReference type="InParanoid" id="Q5CYM2"/>
    <dbReference type="OMA" id="CKLIIDW"/>
    <dbReference type="OrthoDB" id="614844at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005789">
        <property type="term" value="C:endoplasmic reticulum membrane"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000030">
        <property type="term" value="F:mannosyltransferase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.2000">
        <property type="entry name" value="Glycogen Phosphorylase B"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR026051">
        <property type="entry name" value="ALG1-like"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036">
        <property type="entry name" value="BETA1,4 MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13036:SF0">
        <property type="entry name" value="CHITOBIOSYLDIPHOSPHODOLICHOL BETA-MANNOSYLTRANSFERASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13692">
        <property type="entry name" value="Glyco_trans_1_4"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF53756">
        <property type="entry name" value="UDP-Glycosyltransferase/glycogen phosphorylase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="6" id="KW-0256">Endoplasmic reticulum</keyword>
    <keyword evidence="3 11" id="KW-0328">Glycosyltransferase</keyword>
    <keyword evidence="8 10" id="KW-0472">Membrane</keyword>
    <keyword evidence="12" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="4 11" id="KW-0808">Transferase</keyword>
    <keyword evidence="5 10" id="KW-0812">Transmembrane</keyword>
    <keyword evidence="7 10" id="KW-1133">Transmembrane helix</keyword>
    <feature type="transmembrane region" description="Helical" evidence="10">
        <location>
            <begin position="6"/>
            <end position="29"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="9">
        <location>
            <begin position="314"/>
            <end position="350"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="9">
        <location>
            <begin position="322"/>
            <end position="338"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004389"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00004922"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022676"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022679"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022692"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022824"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022989"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023136"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Phobius"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="EMBL" id="EAK90222.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="680" mass="77278" checksum="030D1C09B08BAB2F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="112" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYN0</accession>
    <name>Q5CYN0_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="12">Probable threonine--tRNA ligase, cytoplasmic</fullName>
            <ecNumber evidence="3">6.1.1.3</ecNumber>
        </recommendedName>
        <alternativeName>
            <fullName evidence="10">Threonyl-tRNA synthetase</fullName>
        </alternativeName>
    </protein>
    <gene>
        <name evidence="16" type="ORF">cgd7_1710</name>
    </gene>
    <organism evidence="16 17">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="16 17" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="17">Iowa II</strain>
        </source>
    </reference>
    <reference evidence="18" key="2">
        <citation type="submission" date="2020-12" db="PDB data bank">
            <title>Crystal Structure of the RNA binding domain of Threonyl-tRNA synthetase from Cryptosporidium parvum Iowa II.</title>
            <authorList>
                <person name="Abendroth J."/>
                <person name="Dranow D.M."/>
                <person name="Lorimer D.D."/>
                <person name="Horanyi P.S."/>
                <person name="Edwards T.E."/>
            </authorList>
        </citation>
        <scope>X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 330-763 IN COMPLEX WITH CA(2+) AND ZN(2+)</scope>
    </reference>
    <comment type="catalytic activity">
        <reaction evidence="11">
            <text>tRNA(Thr) + L-threonine + ATP = L-threonyl-tRNA(Thr) + AMP + diphosphate + H(+)</text>
            <dbReference type="Rhea" id="RHEA:24624"/>
            <dbReference type="Rhea" id="RHEA-COMP:9670"/>
            <dbReference type="Rhea" id="RHEA-COMP:9704"/>
            <dbReference type="ChEBI" id="CHEBI:15378"/>
            <dbReference type="ChEBI" id="CHEBI:30616"/>
            <dbReference type="ChEBI" id="CHEBI:33019"/>
            <dbReference type="ChEBI" id="CHEBI:57926"/>
            <dbReference type="ChEBI" id="CHEBI:78442"/>
            <dbReference type="ChEBI" id="CHEBI:78534"/>
            <dbReference type="ChEBI" id="CHEBI:456215"/>
            <dbReference type="EC" id="6.1.1.3"/>
        </reaction>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Cytoplasm</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the class-II aminoacyl-tRNA synthetase family.</text>
    </comment>
    <comment type="caution">
        <text evidence="16">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EC" id="6.1.1.3" evidence="3"/>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90215.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628350.1">
        <property type="nucleotide sequence ID" value="XM_628348.1"/>
    </dbReference>
    <dbReference type="PDB" id="7L3O">
        <property type="method" value="X-ray"/>
        <property type="resolution" value="2.10 A"/>
        <property type="chains" value="A/B/C/D=330-763"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYN0"/>
    <dbReference type="SMR" id="Q5CYN0"/>
    <dbReference type="FunCoup" id="Q5CYN0">
        <property type="interactions" value="266"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYN0"/>
    <dbReference type="GeneID" id="3371735"/>
    <dbReference type="KEGG" id="cpv:cgd7_1710"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_1710"/>
    <dbReference type="InParanoid" id="Q5CYN0"/>
    <dbReference type="OMA" id="WYADGMY"/>
    <dbReference type="OrthoDB" id="5423599at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005739">
        <property type="term" value="C:mitochondrion"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005524">
        <property type="term" value="F:ATP binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046872">
        <property type="term" value="F:metal ion binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0004829">
        <property type="term" value="F:threonine-tRNA ligase activity"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-EC"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006435">
        <property type="term" value="P:threonyl-tRNA aminoacylation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd01667">
        <property type="entry name" value="TGS_ThrRS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00860">
        <property type="entry name" value="ThrRS_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="CDD" id="cd00771">
        <property type="entry name" value="ThrRS_core"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.930.10:FF:000019">
        <property type="entry name" value="Threonine--tRNA ligase"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.980.10:FF:000005">
        <property type="entry name" value="Threonyl-tRNA synthetase, mitochondrial"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.10.20.30">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.40.50.800">
        <property type="entry name" value="Anticodon-binding domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.930.10">
        <property type="entry name" value="Bira Bifunctional Protein, Domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.980.10">
        <property type="entry name" value="Threonyl-trna Synthetase, Chain A, domain 2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="HAMAP" id="MF_00184">
        <property type="entry name" value="Thr_tRNA_synth"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002314">
        <property type="entry name" value="aa-tRNA-synt_IIb"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR006195">
        <property type="entry name" value="aa-tRNA-synth_II"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045864">
        <property type="entry name" value="aa-tRNA-synth_II/BPL/LPL"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004154">
        <property type="entry name" value="Anticodon-bd"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR036621">
        <property type="entry name" value="Anticodon-bd_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012675">
        <property type="entry name" value="Beta-grasp_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR004095">
        <property type="entry name" value="TGS"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR002320">
        <property type="entry name" value="Thr-tRNA-ligase_IIa"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR018163">
        <property type="entry name" value="Thr/Ala-tRNA-synth_IIc_edit"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047246">
        <property type="entry name" value="ThrRS_anticodon"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033728">
        <property type="entry name" value="ThrRS_core"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012947">
        <property type="entry name" value="tRNA_SAD"/>
    </dbReference>
    <dbReference type="NCBIfam" id="TIGR00418">
        <property type="entry name" value="thrS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451:SF46">
        <property type="entry name" value="THREONINE--TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR11451">
        <property type="entry name" value="THREONINE-TRNA LIGASE"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF03129">
        <property type="entry name" value="HGTP_anticodon"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF02824">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00587">
        <property type="entry name" value="tRNA-synt_2b"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF07973">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR01047">
        <property type="entry name" value="TRNASYNTHTHR"/>
    </dbReference>
    <dbReference type="SMART" id="SM00863">
        <property type="entry name" value="tRNA_SAD"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF52954">
        <property type="entry name" value="Class II aaRS ABD-related"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55681">
        <property type="entry name" value="Class II aaRS and biotin synthetases"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55186">
        <property type="entry name" value="ThrRS/AlaRS common domain"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50862">
        <property type="entry name" value="AA_TRNA_LIGASE_II"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51880">
        <property type="entry name" value="TGS"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="evidence at protein level"/>
    <keyword evidence="18" id="KW-0002">3D-structure</keyword>
    <keyword evidence="9 16" id="KW-0030">Aminoacyl-tRNA synthetase</keyword>
    <keyword evidence="7" id="KW-0067">ATP-binding</keyword>
    <keyword evidence="18" id="KW-0106">Calcium</keyword>
    <keyword evidence="4" id="KW-0963">Cytoplasm</keyword>
    <keyword evidence="5" id="KW-0436">Ligase</keyword>
    <keyword evidence="18" id="KW-0479">Metal-binding</keyword>
    <keyword evidence="6" id="KW-0547">Nucleotide-binding</keyword>
    <keyword evidence="8" id="KW-0648">Protein biosynthesis</keyword>
    <keyword evidence="17" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="18" id="KW-0862">Zinc</keyword>
    <feature type="domain" description="TGS" evidence="15">
        <location>
            <begin position="59"/>
            <end position="154"/>
        </location>
    </feature>
    <feature type="domain" description="Aminoacyl-transfer RNA synthetases class-II family profile" evidence="14">
        <location>
            <begin position="360"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="13">
        <location>
            <begin position="594"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="13">
        <location>
            <begin position="596"/>
            <end position="619"/>
        </location>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="371"/>
        </location>
        <ligand>
            <name>Ca(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29108"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="426"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="477"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <feature type="binding site" evidence="18">
        <location>
            <position position="629"/>
        </location>
        <ligand>
            <name>Zn(2+)</name>
            <dbReference type="ChEBI" id="CHEBI:29105"/>
        </ligand>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004496"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00008226"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00013163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022490"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022598"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00022741"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00022840"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00022917"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="ARBA" id="ARBA00023146"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="ARBA" id="ARBA00031900"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="11">
        <source>
            <dbReference type="ARBA" id="ARBA00049515"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="12">
        <source>
            <dbReference type="ARBA" id="ARBA00072369"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="13">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="14">
        <source>
            <dbReference type="PROSITE" id="PS50862"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="15">
        <source>
            <dbReference type="PROSITE" id="PS51880"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="16">
        <source>
            <dbReference type="EMBL" id="EAK90215.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="17">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <evidence type="ECO:0007829" key="18">
        <source>
            <dbReference type="PDB" id="7L3O"/>
        </source>
    </evidence>
    <sequence length="763" mass="87617" checksum="457149FA652CFF01" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="84" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYT7</accession>
    <name>Q5CYT7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="10">SnRNP core protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="10" type="ORF">cgd7_1070</name>
    </gene>
    <organism evidence="10 11">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="10 11" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="11">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the snRNP Sm proteins family.</text>
    </comment>
    <comment type="caution">
        <text evidence="10">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90680.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628293.1">
        <property type="nucleotide sequence ID" value="XM_628291.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYT7"/>
    <dbReference type="FunCoup" id="Q5CYT7">
        <property type="interactions" value="509"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CYT7"/>
    <dbReference type="GeneID" id="3371777"/>
    <dbReference type="KEGG" id="cpv:cgd7_1070"/>
    <dbReference type="InParanoid" id="Q5CYT7"/>
    <dbReference type="OMA" id="DNISCTD"/>
    <dbReference type="OrthoDB" id="10256176at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071013">
        <property type="term" value="C:catalytic step 2 spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:1990726">
        <property type="term" value="C:Lsm1-7-Pat1 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000932">
        <property type="term" value="C:P-body"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0071011">
        <property type="term" value="C:precatalytic spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0046540">
        <property type="term" value="C:U4/U6 x U5 tri-snRNP complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005688">
        <property type="term" value="C:U6 snRNP"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003723">
        <property type="term" value="F:RNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0000398">
        <property type="term" value="P:mRNA splicing, via spliceosome"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="CDD" id="cd01725">
        <property type="entry name" value="LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="2.30.30.100:FF:000053">
        <property type="entry name" value="U6 snRNA-associated Sm-like protein LSm2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="2.30.30.100">
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR010920">
        <property type="entry name" value="LSM_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR047575">
        <property type="entry name" value="Sm"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR001163">
        <property type="entry name" value="Sm_dom_euk/arc"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR016654">
        <property type="entry name" value="U6_snRNA_Lsm2"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829">
        <property type="entry name" value="SNRNP CORE PROTEIN FAMILY MEMBER"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR13829:SF2">
        <property type="entry name" value="U6 SNRNA-ASSOCIATED SM-LIKE PROTEIN LSM2"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF01423">
        <property type="entry name" value="LSM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00651">
        <property type="entry name" value="Sm"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF50182">
        <property type="entry name" value="Sm-like ribonucleoproteins"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS52002">
        <property type="entry name" value="SM"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="3" id="KW-0507">mRNA processing</keyword>
    <keyword evidence="6" id="KW-0508">mRNA splicing</keyword>
    <keyword evidence="7" id="KW-0539">Nucleus</keyword>
    <keyword evidence="11" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="8" id="KW-0687">Ribonucleoprotein</keyword>
    <keyword evidence="5" id="KW-0694">RNA-binding</keyword>
    <keyword evidence="4" id="KW-0747">Spliceosome</keyword>
    <feature type="domain" description="Sm" evidence="9">
        <location>
            <begin position="8"/>
            <end position="82"/>
        </location>
    </feature>
    <feature type="non-terminal residue" evidence="10">
        <location>
            <position position="1"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006850"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022664"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022728"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022884"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023187"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023274"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="9">
        <source>
            <dbReference type="PROSITE" id="PS52002"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="10">
        <source>
            <dbReference type="EMBL" id="EAK90680.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="11">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="107" mass="12480" checksum="CCAB0BE86313F1BF" modified="2005-04-12" version="1" fragment="single">NFSIKLFFNFLQTLIEKQVVVTVELKNDLQITGTLHSIDQYLNIKLNNTTVNQNESFIHLGSLKNCFIRGSVVRYIFFPPSEVDIELLQKACRKELRSMNDCKEKQK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="40" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CYX9</accession>
    <name>Q5CYX9_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Apicomplexan conserved protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd7_610</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000001">
        <property type="protein sequence ID" value="EAK90544.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_628251.1">
        <property type="nucleotide sequence ID" value="XM_628249.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CYX9"/>
    <dbReference type="GeneID" id="3372005"/>
    <dbReference type="KEGG" id="cpv:cgd7_610"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd7_610"/>
    <dbReference type="InParanoid" id="Q5CYX9"/>
    <dbReference type="OrthoDB" id="343049at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 7"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="350"/>
            <end position="446"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="591"/>
            <end position="614"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="359"/>
            <end position="379"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Acidic residues" evidence="1">
        <location>
            <begin position="399"/>
            <end position="410"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90544.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="614" mass="69988" checksum="AA6395855B5B4B14" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="59" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPG7</accession>
    <name>Q5CPG7_CRYPI</name>
    <protein>
        <recommendedName>
            <fullName evidence="9">Kinetochore protein SPC25</fullName>
        </recommendedName>
    </protein>
    <gene>
        <name evidence="12" type="ORF">cgd3_120</name>
    </gene>
    <organism evidence="12 13">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="12 13" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="13">Iowa II</strain>
        </source>
    </reference>
    <comment type="function">
        <text evidence="9">Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.</text>
    </comment>
    <comment type="subunit">
        <text evidence="9">Component of the NDC80 complex.</text>
    </comment>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Chromosome</location>
            <location evidence="1">Centromere</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Nucleus</location>
        </subcellularLocation>
        <subcellularLocation>
            <location evidence="9">Chromosome</location>
            <location evidence="9">Centromere</location>
            <location evidence="9">Kinetochore</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2 9">Belongs to the SPC25 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="12">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87313.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625326.1">
        <property type="nucleotide sequence ID" value="XM_625326.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPG7"/>
    <dbReference type="FunCoup" id="Q5CPG7">
        <property type="interactions" value="23"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CPG7"/>
    <dbReference type="GeneID" id="3372338"/>
    <dbReference type="KEGG" id="cpv:cgd3_120"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_120"/>
    <dbReference type="InParanoid" id="Q5CPG7"/>
    <dbReference type="OMA" id="CEPYIHE"/>
    <dbReference type="OrthoDB" id="340382at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="GO" id="GO:0031262">
        <property type="term" value="C:Ndc80 complex"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-UniRule"/>
    </dbReference>
    <dbReference type="GO" id="GO:0007059">
        <property type="term" value="P:chromosome segregation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd23784">
        <property type="entry name" value="RWD_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.457.50">
        <property type="entry name" value="Chromosome segregation protein Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR045143">
        <property type="entry name" value="Spc25"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR013255">
        <property type="entry name" value="Spc25_C"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281:SF0">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR14281">
        <property type="entry name" value="KINETOCHORE PROTEIN SPC25-RELATED"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF08234">
        <property type="entry name" value="Spindle_Spc25"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="7 9" id="KW-0131">Cell cycle</keyword>
    <keyword evidence="4 9" id="KW-0132">Cell division</keyword>
    <keyword evidence="8 9" id="KW-0137">Centromere</keyword>
    <keyword evidence="3 9" id="KW-0158">Chromosome</keyword>
    <keyword evidence="6 10" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="9" id="KW-0995">Kinetochore</keyword>
    <keyword evidence="5 9" id="KW-0498">Mitosis</keyword>
    <keyword evidence="9" id="KW-0539">Nucleus</keyword>
    <keyword evidence="13" id="KW-1185">Reference proteome</keyword>
    <feature type="domain" description="Chromosome segregation protein Spc25 C-terminal" evidence="11">
        <location>
            <begin position="154"/>
            <end position="224"/>
        </location>
    </feature>
    <feature type="coiled-coil region" evidence="10">
        <location>
            <begin position="51"/>
            <end position="131"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004584"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00006379"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00022454"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00022618"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00022776"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="ARBA" id="ARBA00023306"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="8">
        <source>
            <dbReference type="ARBA" id="ARBA00023328"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="9">
        <source>
            <dbReference type="RuleBase" id="RU367150"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="10">
        <source>
            <dbReference type="SAM" id="Coils"/>
        </source>
    </evidence>
    <evidence type="ECO:0000259" key="11">
        <source>
            <dbReference type="Pfam" id="PF08234"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="12">
        <source>
            <dbReference type="EMBL" id="EAK87313.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="13">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="228" mass="26885" checksum="1DB020A81AF02FAC" modified="2005-04-12" version="1">MEAHSIISNEISEEIQDLKNKLLEWTSGINGMLELGVEKLNDQVSRDINMIKDSSIRIDGLEKRIKDTQELSEIKKVVEIEKEEFKKCFNTNTIALSEKLKRLEKQLQEDRQRFEQEKLVYEADLKVAKQQSLEREKSCRIYSENLGLNIGKVNGNNRFTFTCIDENFPEREFFFDLFYNEKAQLYEGICCNPQVSDFEPNIELLNSKSITFRQFICKMRKSFKQLIK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="48" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CPH7</accession>
    <name>Q5CPH7_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd3_10</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000015">
        <property type="protein sequence ID" value="EAK87323.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625316.1">
        <property type="nucleotide sequence ID" value="XM_625316.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CPH7"/>
    <dbReference type="STRING" id="353152.Q5CPH7"/>
    <dbReference type="GeneID" id="3372319"/>
    <dbReference type="KEGG" id="cpv:cgd3_10"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd3_10"/>
    <dbReference type="InParanoid" id="Q5CPH7"/>
    <dbReference type="OMA" id="HIHTINE"/>
    <dbReference type="OrthoDB" id="343994at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 3"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR051483">
        <property type="entry name" value="MAP7_domain-containing"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073">
        <property type="entry name" value="MICROTUBULE-ASSOCIATED PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR15073:SF1">
        <property type="entry name" value="RETICULOCYTE-BINDING PROTEIN HOMOLOG 2A"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS51257">
        <property type="entry name" value="PROKAR_LIPOPROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="1" id="KW-0175">Coiled coil</keyword>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="3" id="KW-0732">Signal</keyword>
    <feature type="signal peptide" evidence="3">
        <location>
            <begin position="1"/>
            <end position="24"/>
        </location>
    </feature>
    <feature type="chain" id="PRO_5004254346" evidence="3">
        <location>
            <begin position="25"/>
            <end position="1053"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="492"/>
            <end position="556"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="615"/>
            <end position="660"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="702"/>
            <end position="795"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="2">
        <location>
            <begin position="818"/>
            <end position="924"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="492"/>
            <end position="540"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="541"/>
            <end position="551"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="615"/>
            <end position="652"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="719"/>
            <end position="763"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="2">
        <location>
            <begin position="824"/>
            <end position="837"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="838"/>
            <end position="849"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic residues" evidence="2">
        <location>
            <begin position="852"/>
            <end position="905"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="2">
        <location>
            <begin position="906"/>
            <end position="917"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00023054"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="SAM" id="SignalP"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87323.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1053" mass="120096" checksum="6E296E8DC5C3993F" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="74" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CQK5</accession>
    <name>Q5CQK5_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="4">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="4" type="ORF">cgd4_360</name>
    </gene>
    <organism evidence="4 5">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="4 5" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="5">Iowa II</strain>
        </source>
    </reference>
    <comment type="similarity">
        <text evidence="2">Belongs to the APC3/CDC27 family.</text>
    </comment>
    <comment type="caution">
        <text evidence="4">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000009">
        <property type="protein sequence ID" value="EAK87685.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_625643.1">
        <property type="nucleotide sequence ID" value="XM_625643.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CQK5"/>
    <dbReference type="GeneID" id="3372738"/>
    <dbReference type="KEGG" id="cpv:cgd4_360"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd4_360"/>
    <dbReference type="InParanoid" id="Q5CQK5"/>
    <dbReference type="OMA" id="QCISWAN"/>
    <dbReference type="OrthoDB" id="10006270at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 4"/>
    </dbReference>
    <dbReference type="GO" id="GO:0051301">
        <property type="term" value="P:cell division"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="TreeGrafter"/>
    </dbReference>
    <dbReference type="Gene3D" id="1.25.40.10">
        <property type="entry name" value="Tetratricopeptide repeat domain"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR011990">
        <property type="entry name" value="TPR-like_helical_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR019734">
        <property type="entry name" value="TPR_rpt"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558">
        <property type="entry name" value="CELL DIVISION CYCLE 16,23,27"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR12558:SF13">
        <property type="entry name" value="CELL DIVISION CYCLE PROTEIN 27 HOMOLOG"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF13174">
        <property type="entry name" value="TPR_6"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="SMART" id="SM00028">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="3"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF48452">
        <property type="entry name" value="TPR-like"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="PROSITE" id="PS50005">
        <property type="entry name" value="TPR"/>
        <property type="match status" value="1"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="5" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="1 3" id="KW-0802">TPR repeat</keyword>
    <feature type="repeat" description="TPR" evidence="3">
        <location>
            <begin position="604"/>
            <end position="637"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00022803"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00038210"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="PROSITE-ProRule" id="PRU00339"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="4">
        <source>
            <dbReference type="EMBL" id="EAK87685.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="5">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="893" mass="101437" checksum="E4C7ADE50E3B3C92" modified="2005-04-12" version="1"> </sequence>
</entry>
<entry dataset="TrEMBL" created="2007-04-03" modified="2025-10-08" version="77" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CW12</accession>
    <name>Q5CW12_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="8">TATA-box factor binding protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="8" type="ORF">cgd8_2030</name>
    </gene>
    <organism evidence="8 9">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="8 9" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="9">Iowa II</strain>
        </source>
    </reference>
    <comment type="subcellular location">
        <subcellularLocation>
            <location evidence="1">Nucleus</location>
        </subcellularLocation>
    </comment>
    <comment type="similarity">
        <text evidence="2">Belongs to the TBP family.</text>
    </comment>
    <comment type="caution">
        <text evidence="8">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000003">
        <property type="protein sequence ID" value="EAK89402.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627107.1">
        <property type="nucleotide sequence ID" value="XM_627107.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CW12"/>
    <dbReference type="FunCoup" id="Q5CW12">
        <property type="interactions" value="410"/>
    </dbReference>
    <dbReference type="STRING" id="353152.Q5CW12"/>
    <dbReference type="GeneID" id="3374495"/>
    <dbReference type="KEGG" id="cpv:cgd8_2030"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd8_2030"/>
    <dbReference type="InParanoid" id="Q5CW12"/>
    <dbReference type="OMA" id="NCEYEPE"/>
    <dbReference type="OrthoDB" id="2127950at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 8"/>
    </dbReference>
    <dbReference type="GO" id="GO:0005634">
        <property type="term" value="C:nucleus"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-SubCell"/>
    </dbReference>
    <dbReference type="GO" id="GO:0003677">
        <property type="term" value="F:DNA binding"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="UniProtKB-KW"/>
    </dbReference>
    <dbReference type="GO" id="GO:0006352">
        <property type="term" value="P:DNA-templated transcription initiation"/>
        <property type="evidence" value="ECO:0007669"/>
        <property type="project" value="InterPro"/>
    </dbReference>
    <dbReference type="CDD" id="cd04516">
        <property type="entry name" value="TBP_eukaryotes"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="FunFam" id="3.30.310.10:FF:000005">
        <property type="entry name" value="TATA box-binding protein-like 1"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Gene3D" id="3.30.310.10">
        <property type="entry name" value="TATA-Binding Protein"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR000814">
        <property type="entry name" value="TBP"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR012295">
        <property type="entry name" value="TBP_dom_sf"/>
    </dbReference>
    <dbReference type="InterPro" id="IPR033710">
        <property type="entry name" value="TBP_eukaryotic"/>
    </dbReference>
    <dbReference type="PANTHER" id="PTHR10126">
        <property type="entry name" value="TATA-BOX BINDING PROTEIN"/>
        <property type="match status" value="1"/>
    </dbReference>
    <dbReference type="Pfam" id="PF00352">
        <property type="entry name" value="TBP"/>
        <property type="match status" value="2"/>
    </dbReference>
    <dbReference type="PRINTS" id="PR00686">
        <property type="entry name" value="TIFACTORIID"/>
    </dbReference>
    <dbReference type="SUPFAM" id="SSF55945">
        <property type="entry name" value="TATA-box binding protein-like"/>
        <property type="match status" value="2"/>
    </dbReference>
    <proteinExistence type="inferred from homology"/>
    <keyword evidence="4" id="KW-0238">DNA-binding</keyword>
    <keyword evidence="6" id="KW-0539">Nucleus</keyword>
    <keyword evidence="9" id="KW-1185">Reference proteome</keyword>
    <keyword evidence="5" id="KW-0804">Transcription</keyword>
    <keyword evidence="3" id="KW-0805">Transcription regulation</keyword>
    <feature type="region of interest" description="Disordered" evidence="7">
        <location>
            <begin position="1"/>
            <end position="23"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="ARBA" id="ARBA00004123"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="2">
        <source>
            <dbReference type="ARBA" id="ARBA00005560"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="3">
        <source>
            <dbReference type="ARBA" id="ARBA00023015"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="4">
        <source>
            <dbReference type="ARBA" id="ARBA00023125"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="5">
        <source>
            <dbReference type="ARBA" id="ARBA00023163"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="6">
        <source>
            <dbReference type="ARBA" id="ARBA00023242"/>
        </source>
    </evidence>
    <evidence type="ECO:0000256" key="7">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="8">
        <source>
            <dbReference type="EMBL" id="EAK89402.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="9">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="249" mass="28005" checksum="861F44FD640C15F8" modified="2007-04-03" version="1">MSDDILSSLFDPPSTPSSGSRSTSASFLYDMELMPDKSVVNEKIIEASNSIIESSNEIVDLTIRNESITPEIQNIIASVHLQCELDLRMIAISARNAEYNPKKVNAVVMRLRDPKCTGLLFRSGRLMITGARLENDAKLGGKKMAKICQKSGFPKVKFTNFKMENIIATADCKFPIRLEGLAYDHRDFCNYEPELFPGLVYRYHPDNSPTKAVLLLFVSGKVIVTGCKNYQEICNVFDNIYPVLCQYRK</sequence>
</entry>
<entry dataset="TrEMBL" created="2005-04-12" modified="2025-10-08" version="49" xmlns="https://uniprot.org/uniprot">
    <accession>Q5CWQ4</accession>
    <name>Q5CWQ4_CRYPI</name>
    <protein>
        <submittedName>
            <fullName evidence="2">Uncharacterized protein</fullName>
        </submittedName>
    </protein>
    <gene>
        <name evidence="2" type="ORF">cgd6_4170</name>
    </gene>
    <organism evidence="2 3">
        <name type="scientific">Cryptosporidium parvum (strain Iowa II)</name>
        <dbReference type="NCBI Taxonomy" id="353152"/>
        <lineage>
            <taxon>Eukaryota</taxon>
            <taxon>Sar</taxon>
            <taxon>Alveolata</taxon>
            <taxon>Apicomplexa</taxon>
            <taxon>Conoidasida</taxon>
            <taxon>Coccidia</taxon>
            <taxon>Eucoccidiorida</taxon>
            <taxon>Eimeriorina</taxon>
            <taxon>Cryptosporidiidae</taxon>
            <taxon>Cryptosporidium</taxon>
        </lineage>
    </organism>
    <reference evidence="2 3" key="1">
        <citation type="journal article" date="2004" name="Science" volume="304" first="441" last="445">
            <title>Complete genome sequence of the apicomplexan, Cryptosporidium parvum.</title>
            <authorList>
                <person name="Abrahamsen M.S."/>
                <person name="Templeton T.J."/>
                <person name="Enomoto S."/>
                <person name="Abrahante J.E."/>
                <person name="Zhu G."/>
                <person name="Lancto C.A."/>
                <person name="Deng M."/>
                <person name="Liu C."/>
                <person name="Widmer G."/>
                <person name="Tzipori S."/>
                <person name="Buck G.A."/>
                <person name="Xu P."/>
                <person name="Bankier A.T."/>
                <person name="Dear P.H."/>
                <person name="Konfortov B.A."/>
                <person name="Spriggs H.F."/>
                <person name="Iyer L."/>
                <person name="Anantharaman V."/>
                <person name="Aravind L."/>
                <person name="Kapur V."/>
            </authorList>
            <dbReference type="PubMed" id="15044751"/>
            <dbReference type="DOI" id="10.1126/science.1094786"/>
        </citation>
        <scope>NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]</scope>
        <source>
            <strain evidence="3">Iowa II</strain>
        </source>
    </reference>
    <comment type="caution">
        <text evidence="2">The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.</text>
    </comment>
    <dbReference type="EMBL" id="AAEE01000002">
        <property type="protein sequence ID" value="EAK90020.1"/>
        <property type="molecule type" value="Genomic_DNA"/>
    </dbReference>
    <dbReference type="RefSeq" id="XP_627750.1">
        <property type="nucleotide sequence ID" value="XM_627750.1"/>
    </dbReference>
    <dbReference type="AlphaFoldDB" id="Q5CWQ4"/>
    <dbReference type="STRING" id="353152.Q5CWQ4"/>
    <dbReference type="GeneID" id="3375765"/>
    <dbReference type="KEGG" id="cpv:cgd6_4170"/>
    <dbReference type="VEuPathDB" id="CryptoDB:cgd6_4170"/>
    <dbReference type="InParanoid" id="Q5CWQ4"/>
    <dbReference type="OrthoDB" id="342977at2759"/>
    <dbReference type="Proteomes" id="UP000006726">
        <property type="component" value="Chromosome 6"/>
    </dbReference>
    <proteinExistence type="predicted"/>
    <keyword evidence="3" id="KW-1185">Reference proteome</keyword>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="163"/>
            <end position="184"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="201"/>
            <end position="382"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="438"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="470"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="region of interest" description="Disordered" evidence="1">
        <location>
            <begin position="827"/>
            <end position="858"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="163"/>
            <end position="176"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="201"/>
            <end position="226"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="231"/>
            <end position="309"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="310"/>
            <end position="319"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="320"/>
            <end position="333"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="334"/>
            <end position="347"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Pro residues" evidence="1">
        <location>
            <begin position="348"/>
            <end position="358"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Polar residues" evidence="1">
        <location>
            <begin position="444"/>
            <end position="458"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Low complexity" evidence="1">
        <location>
            <begin position="473"/>
            <end position="489"/>
        </location>
    </feature>
    <feature type="compositionally biased region" description="Basic and acidic residues" evidence="1">
        <location>
            <begin position="840"/>
            <end position="858"/>
        </location>
    </feature>
    <evidence type="ECO:0000256" key="1">
        <source>
            <dbReference type="SAM" id="MobiDB-lite"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="2">
        <source>
            <dbReference type="EMBL" id="EAK90020.1"/>
        </source>
    </evidence>
    <evidence type="ECO:0000313" key="3">
        <source>
            <dbReference type="Proteomes" id="UP000006726"/>
        </source>
    </evidence>
    <sequence length="1000" mass="111197" checksum="8BF4B5A7A5B873F5" modified="2005-04-12" version="1"> </sequence>
</entry>
<copyright>
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License
</copyright>
</uniprot>